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Sample records for beterraba sacarina beta

  1. Caracterização do enraizamento da beterraba sacarina (Beta vulgaris L. num solo de aluvião Rooting pattern of sugar beet (Beta vulgaris L. var. saccharifera in a soil from alluvium

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    C. M. Toureiro

    2007-01-01

    Full Text Available O conhecimento do padrão de enraizamento das culturas e sua evolução ao longo do ciclo cultural é importante para a gestão do uso da água e nutrientes do solo. A promoção de práticas de rega eficientes – como a condução da água de rega em tempo real numa determinada área – requer o conhecimento, para além de parâmetros meteorológicos e pedológicos, de parâmetros culturais, como duração dos estádios de desenvolvimento da cultura, coeficientes culturais, capacidade de aprofundamento radical, sensibilidade da cultura à deficiência hídrica, défice de gestão permissível e dos parâmetros que caracterizam as regas efectuadas durante a campanha (data e dotação de rega efectivamente aplicada e avaliação dos sistemas de rega utilizados. O presente estudo teve como objectivo avaliar o desenvolvimento da cultura da beterraba, num solo de aluvião (A – Solos Incipientes, Aluviossolo Moderno não Calcário de Textura Mediana, do Perímetro de Rega do Divor, cujo cenário de gestão da água de rega utilizado foi a optimização do rendimento óptimo da cultura. No ensaio realizado com a cultura da beterraba, durante a campanha de rega de 2004 (Primavera-Verão, utilizou-se o método do minirizotrão, com o qual é possível acompanhar as variações temporais e espaciais do desenvolvimento radical da cultura, permitindo uma caracterização do sistema radical como órgão dinâmico. Para além deste método procedeu-se à abertura de perfis, perpendicularmente à linha de cultura, até à profundidade de 50 cm. Em várias datas de observação durante o ciclo cultural, avaliou-se a capacidade de aprofundamento e peso do túberculo. Em complemento, avaliaram-se outros índices culturais tais como a duração dos estados fenológicos, o índice de área foliar (IAF, matéria verde da parte aérea e a produção total. Consideraram-se as seguintes épocas de observação: desenvolvimento vegetativo (0-69 dias após a

  2. A rentabilidade da beterraba sacarina vs a agro-pecuária nos Açores The profitability of the saccharine beetroot vs dairy farming in the Azores

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    Luísa Calado

    2008-01-01

    Full Text Available Nos Açores a produção de beterraba sacarina com fim industrial é exclusiva da ilha de S. Miguel onde, ao longo do último século, tem ocupado áreas com altitude até 300 metros e declives inferiores a 7%. A área variou entre 3000 hectares na década de sessenta e 200 hectares actualmente. A produtividade é variável situando-se entre as 20 e as 90 toneladas por hectare. Nos Açores a SINAGA é responsável pela transformação e distribuição dos produtos da beterraba. Com base num modelo de programação linear que estima o comportamento dos agricultores dos Açores foi possível concluir que o preço da beterraba influencia a quantidade de beterraba produzida, enquanto o preço do leite tem uma influência reduzida; que o maior efeito no aumento de produção é conseguido com o aumento de área mobilizável para a cultura o que só é possível com a redefinição do apoio técnico ao maneio da cultura.In the Azores the production of sugar beet for industrial uses is exclusive of the island of S. Miguel where along the last century it has occupied areas up to 300 meters and slopes inferior to 7 %. The used area varied between 3000 hectares in the sixties and 200 hectares at present. The productivity is variable being situated between 20 and 90 tons per hectare. In the Azores the SINAGA is responsible for the transformation and distribution of the products of the sugar beet. Using a linear programming model to explain the behaviour of farmers in the Azores it was possible to conclude that the price of sugar beet influences the quantity produced of beetroot while the price of the milk has a reduced influence; and that the biggest effect in the increase of production is got by the increase of cultivable area and with technical support.

  3. Resposta de plantas de beterraba (Beta vulgaris) e de cenoura (Daucus carota) à deriva simulada de glyphosate e clomazone Response of beetroot (Beta vulgaris) and carrot (Daucus carota) to simulated glyphosate and clomazone drift

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    R.P. Rogoli; L.C. Fontana; S.S. Figueredo; J.A. Noldin

    2008-01-01

    Várias espécies de hortaliças são de muita importância para a alimentação humana e tornam-se alvos da deriva de herbicidas, pois comumente são cultivadas nas proximidades de culturas como arroz, soja e milho, pulverizadas com esses produtos. Neste trabalho, objetivou-se verificar possíveis efeitos de doses reduzidas dos herbicidas glyphosate e clomazone sobre plantas de beterraba (Beta vulgaris) e de cenoura (Daucus carota), em diferentes fases de desenvolvimento. As doses avaliadas dos herbi...

  4. Resposta de plantas de beterraba (Beta vulgaris e de cenoura (Daucus carota à deriva simulada de glyphosate e clomazone Response of beetroot (Beta vulgaris and carrot (Daucus carota to simulated glyphosate and clomazone drift

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    R.P. Rogoli

    2008-06-01

    Full Text Available Várias espécies de hortaliças são de muita importância para a alimentação humana e tornam-se alvos da deriva de herbicidas, pois comumente são cultivadas nas proximidades de culturas como arroz, soja e milho, pulverizadas com esses produtos. Neste trabalho, objetivou-se verificar possíveis efeitos de doses reduzidas dos herbicidas glyphosate e clomazone sobre plantas de beterraba (Beta vulgaris e de cenoura (Daucus carota, em diferentes fases de desenvolvimento. As doses avaliadas dos herbicidas foram de 0, 5, 10, 15 e 20% da dose recomendada, equivalentes a 0, 63, 126, 189 e 252 g ha-1 de glyphosate e 0, 14,4, 28,8, 43,2 e 57,6 g ha-1 de clomazone, respectivamente, aplicadas aos 20, 30 e 40 dias após a emergência das culturas. Observou-se aumento no percentual de fitotoxicidade do glyphosate com o incremento na dose do herbicida, e a maior suscetibilidade ocorreu com a deriva nos estádios mais precoces, em ambas as espécies. As doses de clomazone não causaram qualquer sintoma detectável visualmente para as plantas de beterraba e de cenoura. Os resultados sugerem que o herbicida glyphosate causa injúrias às plantas de beterraba e cenoura, independentemente do estádio em que ocorre a interceptação do produto. No entanto, o herbicida clomazone não interfere no desenvolvimento inicial de plantas de beterraba e cenoura.Herbicide drift over horticultural crops is a common problem in the state of Rio Grande do Sul, mainly in areas near rice, soybean and corn fields. The objective of this research was to evaluate glyphosate and clomazone drift effects on beetroot (Beta vulgaris and carrot (Daucus carota plants. The herbicides were sprayed at three different growth stages: 20, 30 and 40 days after seedling emergence. Herbicide rates evaluated were 0, 5, 10, 15, and 20% of the label rate. The sprayed rates were 0, 63, 126, 189 and 252 g ha-1 of glyphosate and 0.0, 14.4, 28.8, 43.2 and 57.6 g ha-1 of clomazone. Glyphosate injury to

  5. Influence of the tannic and gallic acids on stability of betacyanins from red beetroot (Beta vulgaris L. crude extract. INFLUÊNCIA DOS ÁCIDOS TÂNICO E GÁLICO NA ESTABILIDADE DE BETACIANINAS DO EXTRATO BRUTO DE BETERRABA VERMELHA (Beta vulgaris L.

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    D. A. DRUNKLER

    2008-08-01

    Full Text Available The use of e natural colorants in the food industry is limited because to its low stability under preparation, processing and storage conditions. Techniques for natural colorant’s stabilization, such as copigmentation, have been used frequently in scientific researches. The betacyanins that belong to the groups of the betalain presents in the red beetroot and are used as colorant in food. Tannic and gallic acids were used in this study as a copigment of betacyanin crude extract from red beetroot (Beta vulgaris L.. Betacyanin stability was investigated with and without tannic and gallic acid under different storage conditions in 70% ethanol extract: concentrations of 0.925g/100mL and 0.462g/100mL, pH values 5.00±0.05 and 6.80±0.05 at temperature of 25±1ºC, in the dark and in the presence of oxygen. Results revealed that pH and tannic and gallic acid addition (p<0.05 increased significantly the betacyanins half-life time. The tannic and gallic acids provided significant increase in stability of the betacyanins pigments at both concentrations evaluated, at pH value of 5.00 ± 0.05, tannic acid being more effective.

    O uso dos corantes naturais na indústria alimentícia é limitado em função de sua baixa estabilidade frente às condições de preparação, processamento e estocagem. Técnicas de estabilização de corantes naturais, tais como a copigmentação, vem encontrando destaque em pesquisas científicas. As betacianinas (coloração vermelha violeta, pertencentes ao grupo de pigmentos naturais denominados betalaínas, são as que predominam na beterraba vermelha (Beta vulgaris L., sendo utilizadas como corante em alimentos. O objetivo do presente trabalho foi avaliar a estabilidade de betacianinas em extrato de beterraba (Beta vulgaris L. etanólico a 70% adicionadas dos ácidos orgânicos tânico e gálico, nas

  6. COMPORTAMENTO RUMINAL DE TOURINHOS ALIMENTADOS COM DIETAS DE GRAMÍNEA E CONCENTRADO COMERCIAL SUPLEMENTADAS COM HIBISCO E SACARINA

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    Gaspar Pinzón Almeida

    2011-03-01

    Full Text Available Aiming at evaluating hibiscus (Hibiscus rosa-sinensis and sacarina as supplements for young bulls, four crossbred animalswere displayed in a Latin square experimental design. The following treatments were performed: 1 – 75% pasture + 25% concentrate; 2 – 50% pasture + 25% concentrate + 25% hibiscus; 3 – 50% pasture + 25% concentrate + 25% sacarina; and 4 – 25% pasture + 25% concentrate + 25% hibiscus + 25% sacarina. Diet composition, rumen fermentation, DM and CP degradation rates were evaluated. Rumen pH values varied from 5.82 to 6.98, for diets supplemented with hibiscus, at 9h post-feeding, and with sacarina, at the feeding moment. Ammonia N contents did not present great changes when only hibiscus or sacarina were added to the diet, but there was a significant effect when both were added P<0.001. Rumen SCFA concentrations were lower due to saccharine presence in the diet (P<0.01. Sacarina diet presented higher values for readily soluble fraction for DM and CP (P<0.01. Sacarina promoted a higher effect on DM degradation of total diets (P<0.05. Hibiscus and sacarina inclusion increased the degradation of diets for grazing young bulls (P<0.05. Including these feed to the concentrate, the rumen environment and functionality were improved. Thus, it is viable the partial replacement of concentrate by the tested feed.

  7. Armazenamento refrigerado de beterraba minimamente processada em diferentes tipos de corte

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    Kluge Ricardo Alfredo

    2006-01-01

    Full Text Available Beterrabas minimamente processadas apresentam vida de prateira curta, mesmo sob refrigeração, devido à descoloração superficial que deprecia a qualidade do produto. O objetivo do trabalho foi verificar o efeito de três tipos de corte em beterraba minimamente avaliando sua qualidade durante a conservação refrigerada. Os cortes utilizados foram: fatia, cubo e retalho. Após o processamento as beterrabas foram armazenadas a 5degreesC e as avaliações sendo realizadas durante dez dias a cada dois dias. Beterrabas em fatias apresentaram maior respiração e maiores perdas dos pigmentos betalaínas e de sólidos solúveis durante o armazenamento. Através de análise sensorial, verificou-se que a qualidade visual do produto foi mantida por até quatro dias, independente do tipo de corte. O fator que mais depreciou a qualidade de beterraba minimamente processada foi a perda de coloração das raízes (esbranquiçamento. Pode-se concluir que a beterraba minimamente processada em fatias ou cubo apresenta conservação de, no máximo 4 dias, a 5degreesC, enquanto minimamente processada em retalho apresenta 6 dias de conservação.

  8. Avaliação agroeconômica das culturas da beterraba e coentro em função da época de estabelecimento do consórcio Agroeconomic evaluation of sugar beet and coriander depending on the time of intercropping establishment

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    Leilson Costa Grangeiro

    2011-03-01

    Full Text Available A consorciação de culturas é uma prática de cultivo usada na produção de hortaliças, e que influencia sobremaneira a produtividade dessas culturas, além de gerar vários benefícios agroeconômicos. O objetivo do presente trabalho foi avaliar os rendimentos de beterraba (Beta vulgarias L. e coentro (Coriandrum sativum L. em função da época de estabelecimento do consórcio entre essas culturas. O trabalho foi conduzido na Universidade Federal Rural do Semiárido, Mossoró-RN, durante o período de julho a setembro de 2006. O delineamento experimental utilizado foi em blocos completos aleatorizados, com sete tratamentos e quatro repetições. Os tratamentos analisados corresponderam aos cultivos consorciados de beterraba e coentro plantados aos 0; 7 e 14 dias após a semeadura da beterraba (Tratamentos 1; 2 e 3, cultivo solteiro da beterraba (Tratamento 4 e, os cultivos solteiros do coentro plantados nas mesmas épocas de estabelecimento dos consórcios (Tratamentos 5; 6 e 7. O cultivo consorciado de beterraba com coentro é agroeconomicamente viável. Ele deve ser estabelecido com o plantio do coentro realizado simultaneamente ou aos sete dias após a semeadura da beterraba.Intercropping is a cropping practice widely used in the production of vegetables, and that greatly influences the productivity of these crops, and generates multiple agroeconomic benefits. The aim of this study was to evaluate the yield of sugar beet (Beta vulgaris L. and coriander (Coriandrum sativum L. depending on the time of intercropping establishment between these crops. The work was conducted at the Universidade Federal Rural do Semi-arid, Mossoró, RN, during the period from July 2006 to September 2006. The experimental design was of randomized complete blocks with seven treatments and four replications. The treatments consisted of the intercropping of coriander and beet planted at 0, 7 and 14 days after sowing of beet (Treatments 1; 2 and 3, sole crop of

  9. Use of low doses of cobalt 60 gamma radiation on beet (Beta vulgaris L.), carrot (Daucus carota L.) and radish (Raphanus sativus L.) seed to stimulate increase yield; Emprego da radiacao gama do cobalto 60 em sementes de beterraba (Beta vulgaris L.), cenoura (Daucus carota L.) e rabanete (Raphanus sativus L.) para estimular o aumento da producao

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    Bovi, Jose Eduardo

    2000-07-01

    The research had the aim of evaluating the effects of low doses of Cobalt-60 gamma radiation on seeds of radish (Raphanus sativus L.) cultiva Champion, cultivars Nantes Forto (european origin) and Brasilia (Rio Grande do Sul origin) carrot (Daucus carota L. var. sativus (Hoffm.) Thell), and red beet (Beta vulgaris L.) cultivar Tall Top Early Wonder before sowing, its effects on plant growth, on the yield and roots storage of two tillages: with sowing in the same day of radiation and six days after radiation seeds. The data showed that the seeds radiation did not interfered negatively on plants growth, and the species presented differences as roots production and doses on both plantation: radish with 5,0 Gy and 2,5 Gy doses respectively to the first and the second sowings, Brasilia carrot with 2,5 Gy dose to both sowings. Nantes carrot with 2,5 Gy and 5,0 Gy respectively to the first and the second sowings, and beet with 7,5 Gy and 5,0 Gy respectively to the first and the second plantations. There is not statistics difference by Tukey test (5% and 1%) and none relation between seeds radiation and loss weight on roots storage. (author)

  10. Application of low-dose gamma irradiation to extend the shelf life of minimally processed Red Beet (Beta vulgaris sp. vulgaris L.), cv. Early Wonder; Aplicacao de baixas doses de radiacao gama para extensao da vida util de beterraba vermelha (Beta vulgaris ssp. vulgaris L.), cv. Early Wonder, minimamente processada

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    Hernandez, Nilber Kenup

    2006-07-01

    This study was aimed at investigating the effects of low-dose gamma irradiation on shelf-life extension and phyto sanitary safety of minimally processed red beet with basis on physicochemical; microbiological; chemical and sensory analyses. The samples (Beta vulgaris ssp. vulgaris L.), Early Wonder cultivar, were cultivated in the experimental area of the Horticulture Sector of the Departamento de Fitotecnia of the Instituto de Agronomia, Universidade Federal Rural do Rio de Janeiro, Seropedica, RJ, as part of two experiments performed during the second semester of 2005. In each experiment, 1200 plants (40 per linear meter of terrain) were sowed. Physicochemical analyses (fresh mass; length; average diameter and total soluble solids) of the edible part of the red beets (their tuberous roots) were periodically carried out in order to assess the most appropriate time for harvest by monitoring the development of the plants. Those times were found to be 104 and 73 days after transplanting, respectively. The harvested edible part of the roots were minimally processed and separated in two groups: (1) gamma irradiated (with doses of 0.5; 1.0 and 1.5 kGy) and (2) non-irradiated (control). All samples were stored at 8 degree C. Microbiological analyses were performed during the storage period (22 and 21 days, for experiments 1 and 2, respectively) in order to evaluate the phyto sanitary quality of the samples (Salmonella sp.; coliforms and total count of mesophilic aerobic and lactic acid bacteria). The samples irradiated with 1.0 and 1.5 kGy were found to remain appropriate for consumption for 21 days, as compared to only 7 days for the control. Monitoring of chemical composition was also performed and included the determination of saccharose; glucose; fructose and vitamins B1 and B2. No difference was found between the concentrations of those vitamins in irradiated and control samples at the end of the storage period, whereas significant changes in sugar contents were

  11. Potencial de redução de emissões de GEE do bioetanol: contributo da análise de ciclo de vida da beterraba sacarina e do cardo como fontes de biomassa nacionais

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    Gomes, Bruno Miguel da Silva

    2009-01-01

    Actualmente, os biocombustíveis têm sido apontados como uma alternativa promissora aos combustíveis fósseis na actividade de transporte de passageiros e mercadorias, principalmente no quadro de controlo e redução de emissões de gases com efeito de estufa. Com o objectivo de redução da dependência energética do exterior, Portugal deve garantir a inclusão de 10% de biocombustíveis no sector dos transportes, usando como fontes de biomassa culturas energéticas de origem nacional. A...

  12. Deterioração controlada para avaliar o potencial fisiológico de sementes de beterraba Controlled deterioration to evaluate the physiological potential of beetroot seeds

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    Josué B Silva; Roberval D. Vieira

    2012-01-01

    Sementes de hortaliças quase sempre apresentam elevado valor comercial, motivo pelo qual devem ter o potencial fisiológico eficientemente avaliado. O teste de deterioração controlada é um dos recomendados para avaliação do vigor de sementes pequenas, como as de beterraba. O objetivo do trabalho foi determinar o melhor procedimento para a condução de referido teste em sementes de beterraba e sua relação com a emergência de plântulas em campo. Foram utilizados sete lotes de sementes da cultivar...

  13. Seedling formation and field production of beetroot and lettuce in Aquidauana, Mato Grosso do Sul, Brazil Formação de mudas e produção a campo de beterraba e alface em Aquidauana-MS

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    Paulo AM Leal

    2011-12-01

    Full Text Available In horticulture, the proper use of containers and substrates for the production of seedlings are important factors that affect crop productivity in the field. This study aimed to evaluate the effect of different containers and substrates in the production of lettuce (Lactuca sativa, cv Veneranda and beetroot (Beta vulgaris, cv Top Tall Early Wonder seedlings in nursery with monofilament screen, 50% of shading, and the productivity of these species when transplanted to field plots. In protected cultivation, a completely randomized experimental design, in a 3 x 3 factorial scheme (three polystyrene trays, R1= 72, R2= 128 and R3= 200 cells and three substrates, S1= 93% of soil + 7% of organic compost, S2= 86% of soil + 14% of organic compost and S3= 79% of soil + 21% of organic compost was used, with 15 replications, where one plantlet was a replication. In the field, the nine treatments were evaluated in a completely randomized experimental design. The 72 cells tray with 7% commercial organic compost substrate promoted the best beetroot and lettuce seedlings. In the field, the plants from the 72 cell tray produced greater plants, independent of substrates type.Na olericultura o uso adequado de recipientes e substratos para a produção de mudas são fatores importantes e que afetam a produtividade das culturas a campo. No presente trabalho objetivou-se avaliar, em viveiro de tela de monofilamento com 50% de sombreamento, o efeito de diferentes recipientes e substratos na produção de mudas de alface (Lactuca sativa, cv Veneranda e beterraba (Beta vulgaris, cv Top Tall Early Wonder, bem como a produtividade dessas espécies quando transplantadas em canteiros a campo. No ambiente protegido utilizou-se o delineamento experimental inteiramente casualizado, em esquema fatorial 3 x 3, sendo os fatores 3 recipientes (R1= 72, R2= 128 e R3= 200 células de poliestireno e 3 substratos (S1= 93% de solo + 7% de composto orgânico, S2= 86% de solo + 14% de

  14. Manejo de plantas daninhas em beterraba com metamitron e sua persistência em Argissolo Weed control in table beet with metamitron and its persistence in Ultisol-Kandiucults

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    Robert Deuber

    2004-01-01

    Full Text Available O experimento foi realizado no Centro Avançado de Pesquisa Tecnológica do Agronegócio de Frutas (IAC, localizado no município de Jundiaí (SP, em condições usuais de cultivo da beterraba (Beta vulgaris L. cultivar Tall Top Wonder, em Argissolo Vermelho-Amarelo, distrófico. Os objetivos do experimento foram avaliar a eficácia de metamitron, aplicado em pré-emergência, no controle de plantas daninhas; verificar sua seletividade à cultura, e determinar seu período residual. O experimento foi disposto em blocos ao acaso, com quatro repetições; as parcelas foram divididas em duas partes, sendo uma para a beterraba e outra para o estudo do efeito residual. Foram avaliados os efeitos de doses de metamitron (2,8, 3,5 e 4,2 kg.ha-1 de i.a, mantendo-se duas testemunhas: uma sempre capinada e outra mantida com plantas daninhas até o fim do ciclo. As avaliações do controle das plantas daninhas e da seletividade à cultura foram realizadas aos 28 e 70 dias após a aplicação (DAA do herbicida. A persistência foi avaliada aos 0, 21, 40 e 70 DAA, em biotestes, com alface (Lactuca sativa L. cultivar Elisa Crespa como planta-teste. As principais plantas daninhas na área experimental foram: Eleusine indica (L. Gaertn. (capim-pé-de-galinha, Galinsoga parviflora Cav (picão-branco e Coronopus didymus (L. Sm. (mentruz. As doses de metamitron aplicadas não causaram sintomas visíveis de intoxicação à parte aérea das plantas de beterraba. O picão branco e o mentruz foram eficientemente controlados com quaisquer das doses de metamitron. Aos 28 DAA, o capim-pé-de-galinha foi totalmente controlado pelas doses de metamitron aplicadas. Entretanto, aos 70 DAA, somente com as doses de 3,5 e 4,2 kg.ha-1 obteve-se controle eficiente dessa espécie. A atividade residual de metamitron, para as doses de 2,8 e 3,5 kg.ha-1, foi igual a 70 dias e para 4,2 kg.ha-1 foi superior a esse período. O controle de plantas daninhas resultou na obtenção de ra

  15. Progresso temporal da cercosporiose da beterraba em diferentes genótipos e épocas de semeadura na primavera

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    Leandro Luiz Marcuzzo

    2015-09-01

    Full Text Available A cultura da beterraba tem se intensificado devido ao consumo in natura e também pelo processamento industrial de conservas. Na região do Alto Vale do Itajaí, SC, grande parte da sua produção vem de agricultores familiares que a usam em sucessão a cultura da cebola, com semeadura na primavera/verão. Entretanto, nesta época do ano a cercosporiose (Cercospora beticola tem comprometido a produtividade. O objetivo do trabalho foi avaliar o progresso desta doença nos genótipos: All Green, Stays Green, Early Wonder, Cabernet, Boro, Modana e Itapuã e avaliar a severidade em duas épocas de semeadura, na primavera. Os dois ensaios foram conduzidos na Epagri/Estação Experimental de Ituporanga, implantados com 30 dias de diferença entre as semeaduras. O delineamento experimental foi de blocos casualizados com quatro repetições. Para avaliação da severidade da doença foi utilizada uma escala diagramática em dez plantas ao acaso previamente demarcadas. Os dados de severidade foram submetidos à análise de modelos mistos, area abaixo da curva de progresso de doença, taxa de infecção e severidade final. Não houve diferenças no progresso da doença entre os genótipos avaliados nas duas épocas de semeadura de primavera nas condições do Alto Vale do Itajaí, SC.

  16. Superação de dormência em sementes de beterraba por meio de imersão em água corrente Overcoming beetroot seeds dormancy through immersion in running water

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    Josué B. da Silva; Roberval D. Vieira; Arthur B Cecílio Filho

    2005-01-01

    A presença de inibidores de germinação no fruto da beterraba pode comprometer o estande da cultura. O presente trabalho objetivou avaliar a interferência do período de imersão em água corrente no desempenho fisiológico das sementes de beterraba. Para tanto, sementes da cultivar Top Tall Early Wonder foram submetidas à ação de água corrente durante 0 (testemunha), 1; 1,5; 2; 3; 4; 5 e 6 horas, secadas e avaliadas pelo teste de germinação. A lavagem por duas horas foi suficiente para aumentar a...

  17. Deterioração controlada para avaliar o potencial fisiológico de sementes de beterraba Controlled deterioration to evaluate the physiological potential of beetroot seeds

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    Josué B Silva

    2012-09-01

    Full Text Available Sementes de hortaliças quase sempre apresentam elevado valor comercial, motivo pelo qual devem ter o potencial fisiológico eficientemente avaliado. O teste de deterioração controlada é um dos recomendados para avaliação do vigor de sementes pequenas, como as de beterraba. O objetivo do trabalho foi determinar o melhor procedimento para a condução de referido teste em sementes de beterraba e sua relação com a emergência de plântulas em campo. Foram utilizados sete lotes de sementes da cultivar Top Tall Early Wonder, adquiridos no comércio. Após lavagem em água corrente, as sementes foram submetidas aos testes de germinação, velocidade de germinação, envelhecimento acelerado, emergência de plântulas em campo, velocidade de emergência e deterioração controlada (temperaturas de 41 e 45ºC, teores de água de 22, 24 e 26% e períodos de exposição de 12, 24 e 36 horas. As combinações 41ºC/24%/12 h, 41ºC/24%/36 h, 41ºC/26%/36 h e 45ºC/24%/24 h apresentaram potencial para uso na avaliação do vigor de sementes de beterraba. No entanto, sob as combinações de 41°C/24%/12 h ou 45°C/24%/24 h reduziu-se o tempo de condução do teste.Seeds of vegetable crop species always present high commercial value, so the physiological potential must be efficiently evaluated. The controlled deterioration is a recommended test to evaluate seed vigor of small-seeded vegetable crops, such as beetroot seeds. This research was run in order to determine the best controlled deterioration test procedures for beetroot seeds and its relationship with field seedling emergence. Seven commercial seed lots of the cultivar Top Tall Early Wonder were used. After washing in running water, the seeds were tested for germination, speed of germination, accelerated aging, seedling field emergence, emergence rate and controlled deterioration (41 and 45°C, moisture contents of 22, 24 and 26% and exposure times of 12, 24 and 36 hours. The combination of 41

  18. Controle do tombamento de plântulas de beterraba e tomate pelo tratamento de sementes com quitosana Control of beet and tomato damping-off by seed treatment with chitosan

    OpenAIRE

    Sérgio Miguel Mazaro; Américo Wagner Júnior; Idalmir dos Santos; Idemir Citadin; Jean Carlo Possenti; Alfredo de Gouvêa

    2009-01-01

    O objetivo deste trabalho foi avaliar o efeito do tratamento de sementes, com o indutor de resistência quitosana, sobre o tombamento de plântulas de beterraba e tomate, e sua relação com alterações bioquímicas e a defesa vegetal. Cada parcela foi representada por 25 sementes. Os tratamentos consistiram da imersão das sementes em quitosana nas concentrações de 0; 0,25; 0,5; 1; 2 e 4%. Posteriormente, as sementes foram semeadas em bandejas com o substrato infectado com Rhizoctonia sp., e mantid...

  19. Saccharin analysis in pharmaceutical and cosmetic preparations by derivative ultraviolet spectrophotometry Análise da sacarina em preparações farmacêuticas e cosméticas por meio da espectrofotometria derivada no ultravioleta

    Directory of Open Access Journals (Sweden)

    Cristina Duarte Vianna-Soares

    2002-12-01

    Full Text Available Saccharin, a synthetic sweetener constituent of several pharmaceutical and cosmetic preparations, is analyzed qualitatively and quantitatively in the presence of interferences like active ingredients and excipients. A derivative ultraviolet spectrophotometric method employing the second and the fourth orders was used. The calibration data obtained were satisfactory, with a relative precision range of 0.53%-0.72%, and linearity between 0.9998-0.9999. The recovery test results for the toothgel sample ranged between 97.80% and 104.95% in the second order of derivative and between 98.04% and 101.32% in the fourth derivative, respectively, using zero-peak (ZP and peak-peak (PP methods. The suspension sample showed values between 97.35% and 104.72% in the second derivative and between 95.94% to 104.41% in the fourth derivative, respectively, employing the zero-peak (ZP and peak-peak (PP methods. The proposed method showed precision, accuracy and simplicity.A sacarina, adoçante sintético constituinte de várias preparações farmacêuticas e cosméticas, foi analisada de forma qualitativa e quantitativa na presença de substâncias interferentes como princípios ativos e excipientes das formulações. Utilizou-se a espectrofotometria derivada no ultravioleta, por meio da segunda e da quarta ordens de diferenciação. Os resultados obtidos na padronização do método foram satisfatórios e mostraram precisão no intervalo de 0,53%-0,72%, e linearidade entre 0,99980,9999. O teste de recuperação, aplicado na amostra gel dental situou entre 97,80% e 104,95%, para a segunda ordem, e entre 98,04% e 101,32%, para a quarta ordem de diferenciação, respectivamente, empregando os métodos zero-pico (ZP and pico-pico (PP. A amostra suspensão oral mostrou valores entre 97,35% e 104,72%, para a segunda ordem, e valores entre 95,94% e 104,41%, para a quarta ordem de diferenciação, respectivamente, empregando os métodos zero-pico (ZP and pico-pico (PP. O m

  20. Superação de dormência em sementes de beterraba por meio de imersão em água corrente Overcoming beetroot seeds dormancy through immersion in running water

    Directory of Open Access Journals (Sweden)

    Josué B. da Silva

    2005-12-01

    Full Text Available A presença de inibidores de germinação no fruto da beterraba pode comprometer o estande da cultura. O presente trabalho objetivou avaliar a interferência do período de imersão em água corrente no desempenho fisiológico das sementes de beterraba. Para tanto, sementes da cultivar Top Tall Early Wonder foram submetidas à ação de água corrente durante 0 (testemunha, 1; 1,5; 2; 3; 4; 5 e 6 horas, secadas e avaliadas pelo teste de germinação. A lavagem por duas horas foi suficiente para aumentar a germinação das sementes.The presence of germination inhibitors in the fruit of beetroot can reduce the stand of crop. The present work aimed to evaluate the interference of immersion period in running water in the physiological performance of the beetroot seeds. Seeds from cultivar Top Tall Early Wonder were submitted to the action of running water during 0 (control, 1; 1,5; 2; 3; 4; 5 and 6 hours, dried and physiologically evaluated using germination test. Washing the seeds during two hours was enough to increase the germination.

  1. Controle do tombamento de plântulas de beterraba e tomate pelo tratamento de sementes com quitosana Control of beet and tomato damping-off by seed treatment with chitosan

    Directory of Open Access Journals (Sweden)

    Sérgio Miguel Mazaro

    2009-11-01

    Full Text Available O objetivo deste trabalho foi avaliar o efeito do tratamento de sementes, com o indutor de resistência quitosana, sobre o tombamento de plântulas de beterraba e tomate, e sua relação com alterações bioquímicas e a defesa vegetal. Cada parcela foi representada por 25 sementes. Os tratamentos consistiram da imersão das sementes em quitosana nas concentrações de 0; 0,25; 0,5; 1; 2 e 4%. Posteriormente, as sementes foram semeadas em bandejas com o substrato infectado com Rhizoctonia sp., e mantidas em casa de vegetação por 14 dias. A quitosana induziu a resistência das plântulas de beterraba e tomate e reduziu a incidência de tombamento. As concentrações de 1,1 e 2,5% apresentaram maior eficiência na redução do tombamento, para as culturas da beterraba e tomate, respectivamente. O uso da quitosana induz o aumento na atividade da enzima fenilalanina amônia-liase (FAL e interfere nas variáveis bioquímicas foliares de proteínas e açúcares totais e redutores.The objective of this study was to evaluate the effect of seed treatment using the resistance inductor chitosan to control damping-off in tomato and beet seedlings, and its relationship with plant biochemical alterations and plant protection. Each plot was represented by twenty-five seeds. Treatments consisted of seed immersion in a chitosan suspension at 0, 0.25, 0.5, 1, 2 and 4% concentrations. Seeds were then sowed in trays with a substrate infected with Rhizoctonia sp. and maintained in greenhouse conditions for 14 days. Chitosan induced seedling resistance and reduced damping-off. The 1.1 and 2.5% concentrations were more efficient in controling the damping-off for beet and tomato crops respectively. Chitosan increases the phenylalanine ammonialyase (PAL activity and interferes with the total proteins and total and reduced sugars rates in the leaves.

  2. Cobertura do solo com cama-de-frango, com e sem amontoa, na produção de beterraba Soil covering with chicken manure, with and without hilling, on beetroot yield

    Directory of Open Access Journals (Sweden)

    Néstor Antonio Heredia Zárate

    2010-12-01

    Full Text Available O trabalho foi desenvolvido no Horto de plantas medicinais da Universidade Federal da Grande Dourados-UFGD, em Dourados-MS. Foi avaliada a capacidade produtiva da beterraba (Beta vulgaris L. 'Tall Top Early Wonder', cultivada em solo coberto com cama-de-frango (dose de 10 t ha-1 - CCF e sem cobertura com cama-de-frango semidecomposta - SCF e sem e com amontoa, em uma (21 dias após o transplante e duas épocas (21 e 42 dias após o transplante. Os seis tratamentos foram arranjados como fatorial 2 x 3, no delineamento experimental blocos casualizados, com seis repetições. As plantas CCF e com duas amontoas apresentaram a maior altura (25,11cm e superaram em 3,45cm às CCF e sem amontoa, que tiveram menor altura. As maiores produções de massas frescas de folhas (11,41 t ha-1 e de raízes (19,61 t ha-1 foram das plantas CCF e com uma e duas amontoas, respectivamente e superaram em 5,21 t ha-1 e 9,12 t ha-1, respectivamente, às das SCF com uma amontoa, que apresentaram as menores produções. As maiores percentagens de massas secas de folhas (14,36 % e de raízes (17,64 % foram das SCF e com uma amontoa, superando em 1,86 % e 2,08 %, respectivamente, às das SCF com duas amontoas, que apresentaram as menores percentagens. A maior produção de massa fresca de raízes comerciais (15,98 t ha-1, a média por raiz (129,30 g e o diâmetro médio da raiz (68,93 mm, foram das plantas CCF e com duas amontoas. O maior comprimento médio das raízes comerciais (64,48 mm foi das SCF com uma amontoa. As maiores renda bruta (R$ 11.186,00 e renda líquida (R$ 9.746,00 foram do tratamento CCF com duas amontoas, que superaram em 124,12 % e 108,65 %, respectivamente, às do SCF e uma amontoa.This project was carried out at Medicinal Plant Garden of the Federal University of Grande Dourados - UFGD, in Dourados-MS. Yield capacity of 'Tall Top Early Wonder ' beetroot (Beta vulgaris L. was evaluated when cultivated in soil covering with semi-decomposed chicken

  3. Beta Thalassemia

    Science.gov (United States)

    ... South Asian (Indian, Pakistani, etc.), Southeast Asian and Chinese descent. 1 Beta Thalassemia ßß Normal beta globin ... then there is a 25% chance with each pregnancy that their child will inherit two abnormal beta ...

  4. The effects of the coexistence of weed communities on table beet yield during early crop development = Efeitos de convivência da comunidade de plantas daninhas na produção de beterraba durante o desenvolvimento inicial da cultura

    Directory of Open Access Journals (Sweden)

    Leonardo Bianco Carvalho

    2010-10-01

    Full Text Available The objective was to evaluate the effects of initial weedy periods on the weed community and on the productivity of direct seeded and transplanted table beet cropping systems. A field trial was conducted at São Paulo State University, Brazil, in a randomized complete block design using a 2 x 13 factorial scheme. Direct seeding and seedling transplanting methods were evaluated within thirteen increasing weekly weedy periods. Weed relative importance was calculated and weed density and weed dry matter accumulation data were analyzed by nonlinear regression as well as beet yield and stand, which were submitted to analysis of variance. Amaranthus viridis, Coronopus didymus, Cyperus rotundus, Digitaria nuda, Galinsoga parviflora and Nicandra physaloides were the most important weeds found, with special reference to C. didymus. Weed dry matter accumulation was greater in the direct seeded crop, although weed density was higher in the transplanted crop. Transplanted beet yield was greater than of direct seeded beet in the weed-free treatment during the whole crop cycle. Crop-weed coexistence could remain for four and seven weeks after seeding/transplanting in direct seeded and in transplanted beet, respectively, before reducing yield economically. Thus, direct seeded crop was more susceptible to weed interference than the transplanted one.Objetivando avaliar efeitos de períodos de infestação inicial na comunidade infestante e na produtividade da beterraba em sistema de semeadura direta e transplantio, conduziu-se um experimento em delineamento de blocos casualizados, esquema fatorial 2 x 13. Métodos de semeadura direta e transplante de mudas foram avaliados dentro de 13 períodos semanais crescentes de infestação. Importância relativa, densidade e matéria seca acumulada pelas plantas daninhas foram analisadas por regressão não-linear, assim como produtividade e estande da cultura de beterraba, que foram submetidos à análise de vari

  5. Caída de presión en lecho fijo de cubos de papa, remolacha y zanahoria considerando encogimiento Queda de pressão em leito fixo de cubos de batata, beterraba e cenoura considerando encolhimento

    Directory of Open Access Journals (Sweden)

    Javier Telis-Romero

    2003-12-01

    Full Text Available En este trabajo fue determinada experimentalmente la porosidad de lechos de cubos de papa, remolacha y zanahoria en función de la humedad con aristas iniciales de 8mm. La porosidad del lecho, con diferentes contenidos de humedad obtenida por secado a 70ºC por diferentes tempos, fue calculada utilizando las determinaciones experimentales de volumen del lecho y volumen real de las partículas. Estos dos volumenes fueran bien representados por ecuaciónes lineares basadas en la Ley de la aditividad de los volumens. La porosidad fue representada satisfactoriamente por una ecuación parabólica. La relación volumen del lecho adimensional y humedad fue representada por polinomios de tercer grado. Utilizando un equipamiento con sistema de control, fue determinada experimentalmente la caída de presión a través de un lecho fijo de cubos de papas, zanahoria y remolacha de 100mm de espesura y los resultados fueron representados de manera satisfactoria por una ecuación obtenida por una modificación empírica del modelo de Ergun. Como era de esperarse, la caída de pression aumento com la disminución de la porosidad del lecho, consequencia del encogimiento de los productos.Neste trabalho, o porosidade de leitos de cubos de batata, beterraba e cenoura com arestas iniciais de 8mm, foi determinada experimentalmente em função da umidade. A porosidade do leito, com diferentes umidades, obtidas por secagem a 70ºC por tempos diferentes, foi calculada utilizando-se as determinações experimentais de volume do leito e volume real das partículas. Esses dois volumes foram bem representados por equações lineares baseadas na lei da adtividade dos volumes. A porosidade foi representada satisfatoriamente por uma equação parabólica. A relação entre o volume do leito admensional e a umidade foram representadas por polinômios de terceiro grau. A queda de pressão através de um leito fixo de cubos de batata, beterraba e cenoura de 100mm de espessura foi

  6. Sensory acceptance tests of red beet (Beta vulgaris ssp. vulgaris L.), cv. Early Wonder, minimally processed and irradiated; Testes sensoriais de aceitacao da beterraba vermelha (Beta vulgaris ssp. vulgaris L.), cv. Early Wonder, minimamente processada e irradiada

    Energy Technology Data Exchange (ETDEWEB)

    Hernandes, Nilber Kenup; Vital, Helio de Carvalho, E-mail: nilberkenup@ctex.eb.b [Centro Tecnologico do Exercito (CTEx), Rio de Janeiro, RJ (Brazil). Secao de Defesa Nuclear; Coneglian, Regina Celi Cavestre [Universidade Federal Rural do Rio de Janeiro (UFRRJ), Rio de Janeiro, RJ (Brazil). Inst. de Agronomia. Dept. de Fitotecnia; Godoy, Ronoel Luiz de Oliveira; Freire Junior, Murillo [EMBRAPA Agroindustria de Alimentos, Rio de Janeiro, RJ (Brazil)

    2007-08-15

    Red beet (Early Wonder) was cultivated in an experimental area of the Department of Fitotecnia at the Institute of Agronomy at the Rural Federal University of Rio de Janeiro. After harvest, the roots were minimally processed; packed; exposed to different doses of gamma radiation (0; 0.5; 1.0 and 1.5 kGy) and stored for 20 days at 8.0 deg C. Sensory evaluations were performed 1; 9; 13 and 20 days after irradiation by 12 testers who rated the overall appearance and aroma on a hedonic scale. The results indicated that the irradiated samples remained within the limit of acceptance for 20 days. In addition, the aroma was found to be a more sensitive indicator of the effect of different doses of radiation to the acceptance of the product. (author)

  7. Desenvolvimento e estado nutricional da beterraba em função da omisão de nutrientes Effect of macronutrient omission on growth and nutritional status on table beet

    Directory of Open Access Journals (Sweden)

    Adriana U Alves

    2008-06-01

    Full Text Available Com o objetivo de avaliar o efeito da omissão de macronutrientes no desenvolvimento e no estado nutricional da beterraba, assim como descrever sintomas visuais de deficiência nutricional, um experimento foi conduzido em casa de vegetação da UNESP, Campus de Jaboticabal, SP. O delineamento experimental foi inteiramente casualizado, com sete tratamentos, que corresponderam à solução completa (macro e micronutrientes e à omissão individual de N, P, K, Ca, Mg e S, com três repetições. Avaliou-se a altura das plantas, o número de folhas, a área foliar, a matéria seca da parte aérea, da raiz e planta inteira, os teores dos macronutrientes da parte aérea e raiz e descritos as desordens nutricionais. As omissões individuais de N, P, K e Ca foram as mais limitantes para o crescimento vegetativo da beterraba, reduzindo consideravelmente a altura, o número de folhas e as matérias secas de parte aérea, raiz e planta inteira. Foram observados sintomas de deficiência nutricional de cada elemento. Os teores dos macronutrientes na parte aérea do tratamento completo e com omissão dos nutrientes foram respectivamente: N = 32,9 - 13,8; P = 9,0 - 0,8; K = 126,0 - 15,1; Ca = 12,0 - 1,0; Mg = 10,1 - 0,7; S = 3,6 - 1,2 g kg-1.An experiment was conducted under greenhouse conditions, in Jaboticabal, São Paulo State, Brazil, to evaluate the effects of macronutrient omission on beet nutritional status and development, as well as to describe nutritional deficiency symptoms. The experiment was arranged in completely randomized design with three replications and seven treatments, corresponding to complete nutritive solution (macro and micronutrients and individual N, P, K, Ca, Mg and S omission. Plant height, number of leaves, leaf area, shoot, root and whole plant dry mass and macronutrient levels were determined and nutritional deficiency symptoms were described. Individual omissions of N, P, K or Ca were the most limiting for beet growth

  8. Respiratory activity and pigment metabolism in fresh-cut beet roots treated with citric acid Atividade respiratória e metabolismo dos pigmentos de beterrabas minimamente processadas tratadas com ácido cítrico

    Directory of Open Access Journals (Sweden)

    Ricardo A Kluge

    2008-12-01

    Full Text Available Beet roots cv. Early Wonder were graded for firmness, color and size, and were peeled inside a cold room (10ºC. Roots were then shredded (2 mm thick, sanitized for 6 minutes (NaClO/200 mg L-1, rinsed and centrifuged. Fresh-cut beet roots were then treated for 5 minutes with citric acid in the following concentrations: 0 (control, 500; 1,000; 1,500 and 2,000 mg L-1. The material was centrifuged again, placed in trays, wrapped with PVC plastic film, and stored at 5ºC and 85-90% HR for 10 days. Every two days, treatments were analyzed for respiratory activity and betacyanin and betaxanthin contents. The application of citric acid caused the reduction of respiratory rate in the fresh-cut tissue. In the second day of storage, control showed the highest respiratory activity among treatments, reaching around 77 mL CO2 kg-1 h-1. Citric acid solution dips in a concentration higher than 500 mg L-1 contributed to a decrease in respiratory activity and no peak in CO2 evolution was observed. There were significant differences among all treatments during the storage period for the contents of betacyanin, which were around 40; 45; 48; 51 and 55 mg 100 g-1 for the fresh-cut material treated with 0; 500; 1,000; 1,500 and 2,000 mg L-1 of citric acid, respectively.Also, levels of betaxanthin were around 25; 29; 33; 35 and 39 mg 100 g-1 for the material treated with 0; 500; 1,000; 1,500 and 2,000 mg L-1 of citric acid, respectively. The application of citric acid after minimal processing apparently have the ability to reduce respiratory rate and the degradation of pigments, which contributes to extend the shelf life of the fresh-cut product.Beterrabas 'Early Wonder' foram selecionadas quanto à firmeza, cor e tamanho e descascadas em câmara fria (10ºC. As raízes foram cortadas (2 mm de espessura, sanitizadas, enxaguadas e centrifugadas. As beterrabas foram tratadas com ácido cítrico nas concentrações: 0 (controle, 500; 1000; 1500 e 2000 mg L-1. O produto

  9. PRODUÇÃO E CONCENTRAÇÃO DE METAIS PESADOS EM PLANTAS DE BETERRABA ADUBADAS COM COMPOSTO DE LIXO URBANO

    Directory of Open Access Journals (Sweden)

    Regynaldo Arruda Sampaio

    2008-01-01

    Full Text Available The objective of this work was to evaluate the effect of the urban waste compost on the yield and heavy metals concentrations in red beet plants (Beta vulgaris L. in soils with different textures. The experiment was carried out in greenhouse in polyethylene recipients of 9 dm3. The experimental treatments resulted from a 3 x 4 factorial arrangement of a Red Yellow Latosol, sandy clay loam, (LVAfaa, a Red Yellow Latosol, loamy sand, (LVAfa and a Quartzarenic Neosol, sand loam, (RQ, combined with the urban waste compost doses of 0, 30, 60 and 90 t/ha, in dry base. The experimental design was in randomized blocks with three replications of the treatments. Soil pH, fresh and dry matter weight and Zn, Cu, Cd, Pb and Ni concentrations in the soil and the leaf tissue were determined. Amongst heavy metals determined, Zn and Cu had been only influenced by the soil texture, being biggest concentrations in the soil with bigger amount of clay. The dry and fresh weights of the red beet root had increased with the increment of the doses of compost, having reached maximum values, inside of the experimental interval, with the 90 t.ha-1. Otherwise, the heavy metal content in red beet root decreased with the increase of the doses of compost. As much the Ni how much the Pb had presented content level in root above of the allowed maximum limits for the consumption, as values established for the Brazilian legislation.

  10. Ocorrência de plantas daninhas no cultivo de beterraba com cobertura morta e adubação orgânica Weed occurrence in sugar beet crop under mulching and organic fertilization

    Directory of Open Access Journals (Sweden)

    M.A.N Sediyama

    2010-12-01

    Full Text Available A cobertura do solo é prática importante na produção de hortaliças que também auxilia no controle de plantas daninhas. Praticamente, não existem pesquisas para o controle alternativo de plantas daninhas em beterraba, e são poucos os herbicidas indicados para a cultura. Neste trabalho, objetivou-se avaliar o efeito da cobertura do solo com palha de café ou bagaço de cana-de-açúcar e de doses de lodo de lagoa de decantação de águas residuárias de suinocultura na incidência de plantas daninhas e na produtividade de beterraba, cultivar Early Wonder. O experimento foi realizado na Fazenda Experimental da EPAMIG, em Oratórios-MG. Utilizou-se o esquema de parcelas subdivididas no delineamento experimental de blocos casualizados, com quatro repetições. Nas parcelas foram dispostos três tipos de cobertura do solo: bagaço de cana-de-açúcar, palha de café e ausência de cobertura, e nas subparcelas utilizaram-se cinco doses de lodo de lagoa de decantação de águas residuárias de suinocultura (0, 10, 20, 40 e 60 t ha-1. Aos 45 dias após o transplantio (DAT das mudas foi avaliada a população de plantas daninhas, e aos 70 DAT realizou-se a colheita. A palha de café e o bagaço de cana-de-açúcar foram eficazes na redução da massa fresca total das plantas daninhas, devido ao efeito supressor da cobertura morta sobre as dicotiledôneas. Todavia, a massa seca de tiririca aumentou com o uso de palha de café, enquanto a massa seca das outras monocotiledôneas não apresentou diferença entre os três tratamentos. O aumento das doses de lodo promoveu redução linear da massa seca de monocotiledôneas, exceto de tiririca. A cobertura com palha de café proporcionou maior massa unitária de raiz e maior produtividade de raízes comerciais, independentemente das doses de lodo.Soil covering is an important practice in vegetable production, also helping in weed control. There is almost no research involving alternative weed control

  11. Produtividade e exportação de nutrientes em beterraba cultivada com cobertura morta e adubação orgânica Yield and nutrient export of sugar beet under mulching and organic fertilization

    Directory of Open Access Journals (Sweden)

    Maria A. N. Sediyama

    2011-09-01

    Full Text Available Objetivou-se, com este trabalho, avaliar o efeito da cobertura do solo e doses de lodo de lagoa de decantação de água residuária de suinocultura na produtividade e na exportação de nutrientes pela beterraba, cultivar Early Wonder. O experimento foi conduzido na Fazenda Experimental Vale do Piranga, pertencente à EPAMIG, Zona da Mata, em Oratórios, MG, no período de 07/08/08 a 09/11/08, no delineamento de blocos casualizados em parcelas subdivididas com quatro repetições. Nas parcelas foram dispostos três tipos de cobertura de solo: bagaço de cana-de-açúcar, palha de café e sem cobertura e, nas subparcelas, foram usadas cinco doses do lodo de lagoa: 0; 10; 20; 40 e 60 t ha-1. Aos 70 dias após o transplante das mudas realizou-se a colheita. A cobertura com palha de café proporcionou maior massa unitária de raiz e maior produtividade de raízes comerciais, independente das doses de lodo. Os nutrientes mais exportados pela parte aérea das plantas foram Ca, Mg e S e, pelas raízes, N, P e K. Com a população de 400.000 plantas ha-1e produtividade de 34,22 t ha-1, as quantidades médias de N, P, K, Ca, Mg e S exportadas pelas raízes foram 140; 24; 180; 8, 17 e 5 kg ha-1e, para Zn, Fe, Mn, Cu e B, 371, 435, 320, 74 e 250 g ha-1, respectivamente.This work aimed to evaluate the effect of soil cover and doses of sludge from sedimentation pond of swine wastewater on yield and nutrient export in sugar beet cultivar Early Wonder. The experiment was conducted at the Vale do Piranga Experimental Farm belonging to EPAMIG Zona da Mata in Oratórios (MG, from 07/08/08 to 09/11/08. The experiment was arranged in a split-plot in randomized block design with four replications. The main plots consisted of three types of mulching: sugarcane bagasse, coffee husk and without any cover, and the subplots of five doses of sludge: 0, 10, 20, 40 and 60 t ha-1. At 70 days after transplanting, harvest was carried out. Mulching with coffee husk provided

  12. BETA-S, Multi-Group Beta-Ray Spectra

    International Nuclear Information System (INIS)

    1 - Description of program or function: BETA-S calculates beta-decay source terms and energy spectra in multigroup format for time-dependent radionuclide inventories of actinides, fission products, and activation products. Multigroup spectra may be calculated in any arbitrary energy-group structure. The code also calculates the total beta energy release rate from the sum of the average beta-ray energies as determined from the spectral distributions. BETA-S also provides users with an option to determine principal beta-decaying radionuclides contributing to each energy group. The CCC-545/SCALE 4.3 (or SCALE4.2) code system must be installed on the computer before installing BETA-S, which requires the SCALE subroutine library and nuclide-inventory generation from the ORIGEN-S code. 2 - Methods:Well-established models for beta-energy distributions are used to explicitly represent allowed, and 1., 2. - and 3. -forbidden transition types. Forbidden non-unique transitions are assumed to have a spectral shape of allowed transitions. The multigroup energy spectra are calculated by numerically integrating the energy distribution functions using an adaptive Simpson's Rule algorithm. Nuclide inventories are obtained from a binary interface produced by the ORIGEN-S code. BETA-S calculates the spectra for all isotopes on the binary interface that have associated beta-decay transition data in the ENSDF-95 library, developed for the BETA-S code. This library was generated from ENSDF data and contains 715 materials, representing approximately 8500 individual beta transition branches. 3 - Restrictions on the complexity of the problem: The algorithms do not treat positron decay transitions or internal conversion electrons. The neglect of positron transitions in inconsequential for most applications involving aggregate fission products, since most of the decay modes are via electrons. The neglect of internal conversion electrons may impact on the accuracy of the spectrum in the low

  13. Levered and unlevered Beta

    OpenAIRE

    Fernandez, Pablo

    2003-01-01

    We prove that in a world without leverage cost the relationship between the levered beta ( L) and the unlevered beta ( u) is the No-costs-of-leverage formula: L = u + ( u - d) D (1 - T) / E. We also analyze 6 alternative valuation theories proposed in the literature to estimate the relationship between the levered beta and the unlevered beta (Harris and Pringle (1985), Modigliani and Miller (1963), Damodaran (1994), Myers (1974), Miles and Ezzell (1980), and practitioners) and prove that all ...

  14. Betting Against Beta

    DEFF Research Database (Denmark)

    Frazzini, Andrea; Heje Pedersen, Lasse

    .S. equities, 20 international equity markets, Treasury bonds, corporate bonds, and futures; (2) A betting-against-beta (BAB) factor, which is long leveraged low beta assets and short high-beta assets, produces significant positive risk-adjusted returns; (3) When funding constraints tighten, the return of the...

  15. Forward-Looking Betas

    DEFF Research Database (Denmark)

    Christoffersen, Peter; Jacobs, Kris; Vainberg, Gregory

    Few issues are more important for finance practice than the computation of market betas. Existing approaches compute market betas using historical data. While these approaches differ in terms of statistical sophistication and the modeling of the time-variation in the betas, they are all backward-...

  16. In vitro germination of beetroot seeds treated with Ga3 and sucrose / Germinação in vitro de sementes de beterraba tratadas com ácido giberélico em diferentes concentrações de sacarose no meio de cultura

    Directory of Open Access Journals (Sweden)

    Paulo Cezar Cavatte

    2010-09-01

    Full Text Available The objective of this study was to evaluate the in vitro germination of beetroot seeds, cv. Early Wonder Tall Top, treated with gibberellic acid and sucrose at different concentrations. A randomized complete block design in a 2 x 5 factorial arrangement with five replications was used. The beetroot seeds ware pre-soaked in gibberellic acid (GA3 and destilated water during six hours, maintained of five concentration of culture medium (0, 15, 30, 45, 60 g L-1. Seeds treated with GA3 and maintained in medium with sucrose in the concentrations of 15 g L-1 presented the highest germination, while seedlings with the highest vigor were obtained with seeds maintained in the medium at 15 and 30 g L-1 of saccharose.O objetivo deste trabalho foi avaliar a germinação in vitro de sementes de beterraba, cv. Early Wonder Tall Top, tratadas com ácido giberélico em diferentes concentrações de sacarose no meio de cultura. Utilizou-se o delineamento em blocos casualizados, em um esquema fatorial 2 x 5, com cinco repetições. Os tratamentos foram sementes pré-embebidas em ácido giberélico (GA3 e sementes pré-embebidas em água destilada por seis horas, mantidas em cinco concentrações de sacarose no meio de cultura (0; 15; 30; 45; e 60 g L-1. Sementes tratadas com GA3, mantidas no meio de cultura com sacarose na concentração de 15 g L-1, apresentam maior porcentagem de germinação, enquanto plântulas mais vigorosas foram obtidas a partir de sementes mantidas nos meios suplementados com 15 e 30 g L-1 de sacarose.

  17. Koedam {beta} factors revisited

    Energy Technology Data Exchange (ETDEWEB)

    Lawler, J.E. [Physics Department, University of Wisconsin, Madison, WI (United States); Doughty, D.A. [Perkin-Elmer Optoelectronics, Santa Clara, CA (United States); Lister, G.G. [OSRAM SYLVANIA Inc., Beverly, MA (United States)

    2002-07-21

    A Koedam {beta} factor makes it possible to compute the total output power in line radiation from a positive column discharge using a single radiance measurement normal to an aperture in the wall. The results of analytic derivations of {beta} factors are presented for columns with uniform ({beta}=1.0) and parabolic ({beta}=0.75) excitation rates per unit volume and with negligible opacity. A Monte Carlo code for simulating radiation trapping with a spatially uniform density of absorbing atoms is then used to determine {beta} factors as a function of opacity. The code includes partial frequency redistribution and a Voigt line shape with radiative broadening, resonance collisional broadening, and Doppler broadening. The resulting {beta} factors are found to be nearly independent of opacity over a wide range of column radii for spectral line shapes dominated by Doppler broadening or by resonance collisional broadening. Additional Monte Carlo simulations are used to study {beta} factors as a function of a non-uniform density of absorbing atoms from radial cataphoresis with line shapes dominated by Doppler broadening, foreign gas broadening, and resonance collisional broadening. Radial cataphoresis is found to increase {beta} factors in all cases. Geometrical effects, refraction, and imperfect transmission at the glass wall are studied and found to decrease {beta} factors. (author)

  18. Beta-energy averaging and beta spectra

    International Nuclear Information System (INIS)

    A simple yet highly accurate method for approximately calculating spectrum-averaged beta energies and beta spectra for radioactive nuclei is presented. This method should prove useful for users who wish to obtain accurate answers without complicated calculations of Fermi functions, complex gamma functions, and time-consuming numerical integrations as required by the more exact theoretical expressions. Therefore, this method should be a good time-saving alternative for investigators who need to make calculations involving large numbers of nuclei (e.g., fission products) as well as for occasional users interested in restricted number of nuclides. The average beta-energy values calculated by this method differ from those calculated by ''exact'' methods by no more than 1 percent for nuclides with atomic numbers in the 20 to 100 range and which emit betas of energies up to approximately 8 MeV. These include all fission products and the actinides. The beta-energy spectra calculated by the present method are also of the same quality

  19. Double beta decay experiments

    OpenAIRE

    Barabash, A. S.

    2011-01-01

    The present status of double beta decay experiments is reviewed. The results of the most sensitive experiments are discussed. Proposals for future double beta decay experiments with a sensitivity to the $$ at the level of (0.01--0.1) eV are considered.

  20. Negative Beta Encoder

    CERN Document Server

    Kohda, Tohru; Aihara, Kazuyuki

    2008-01-01

    A new class of analog-digital (A/D), digital-analog (D/A) converters as an alternative to conventional ones, called $\\beta$-encoder, has been shown to have exponential accuracy in the bit rates while possessing self-correction property for fluctuations of amplifier factor $\\beta$ and quantizer threshold $\

  1. Betting against Beta

    DEFF Research Database (Denmark)

    Frazzini, Andrea; Heje Pedersen, Lasse

    2014-01-01

    We present a model with leverage and margin constraints that vary across investors and time. We find evidence consistent with each of the model's five central predictions: (1) Because constrained investors bid up high-beta assets, high beta is associated with low alpha, as we find empirically for...

  2. Rapid synthesis of beta zeolites

    Energy Technology Data Exchange (ETDEWEB)

    Fan, Wei; Chang, Chun -Chih; Dornath, Paul; Wang, Zhuopeng

    2015-08-18

    The invention provides methods for rapidly synthesizing heteroatom containing zeolites including Sn-Beta, Si-Beta, Ti-Beta, Zr-Beta and Fe-Beta. The methods for synthesizing heteroatom zeolites include using well-crystalline zeolite crystals as seeds and using a fluoride-free, caustic medium in a seeded dry-gel conversion method. The Beta zeolite catalysts made by the methods of the invention catalyze both isomerization and dehydration reactions.

  3. Formation of beetroot seedlings in different protected environments, substrates and containers in Aquidauana region, State of Mato Grosso do Sul, Brazil Formação de mudas de beterraba em diferentes ambientes protegidos, substratos e recipientes na região de Aquidauana-MS

    Directory of Open Access Journals (Sweden)

    Letícia C. de Oliveira

    2012-06-01

    Full Text Available This study with beetroot seedlings, cultivar Top Tall Early Wonder, was carried out at the State University of Mato Grosso do Sul (UEMS/Aquidauana, from October to November 2008. Three environments of cultivation were used: greenhouse; nursery with monofilament screen of 50 % of shading; and nursery with aluminized thermal reflective screen of 50% of shading. In these environments, three polystyrene trays of 72, 128 and 200 cells, filled with four substrates, were tested: soil; Plantmax®; coconut fiber and vermiculite. There were no replication environments and then each one was considered an experiment alone. For each environment, it was adopted a completely randomized design in factorial scheme 3x4 (three trays x four substrates, with four replications, performing individual analysis of variance and joint analysis of experiments for environment comparisons. The monofilament screen is the best environment for seedlings produced in tray of 72 cells, and the greenhouse was the best environment for seedlings produced in trays of 128 cells. The best seedlings were formed in the tray of 72 cells. Vermiculite was the best substrate.Pesquisa com formação de mudas de beterraba, cultivar Top Tall Early Wonder, foi desenvolvida na UEMS/Aquidauana, nos meses de outubro e novembro de 2008. Foram utilizados três ambientes de cultivo: estufa agrícola; viveiro de tela de monofilamento, com 50% de sombreamento, e viveiro de tela termorrefletora aluminizada, com 50% de sombreamento. No interior destes ambientes, foram testadas bandejas de poliestireno de 72; 128 e 200 células, preenchidas com quatro substratos: solo, Plantmax®, fibra de coco fina e vermiculita. Por não haver repetições dos ambientes, cada um foi considerado um experimento. Para cada ambiente de cultivo, foi adotado o delineamento experimental inteiramente casualizado, em esquema fatorial 3 x 4 (três bandejas x quatro substratos, com quatro repetições, realizando análises de vari

  4. Beta-carotene

    Science.gov (United States)

    ... and deterioration of the lining of the mouth (oral mucositis). Taking beta-carotene by mouth doesn’t appear to prevent the development of oral mucositis during radiation therapy or chemotherapy. Pancreatic cancer. Taking ...

  5. Neutrinoless double beta decay

    International Nuclear Information System (INIS)

    The physics potential of neutrinoless double beta decay is discussed. Furthermore, experimental considerations as well as the current status of experiments are presented. Finally, an outlook towards the future, work on nuclear matrix elements and alternative processes is given. (author)

  6. Neutrinoless double beta decay

    Indian Academy of Sciences (India)

    Kai Zuber

    2012-10-01

    The physics potential of neutrinoless double beta decay is discussed. Furthermore, experimental considerations as well as the current status of experiments are presented. Finally, an outlook towards the future, work on nuclear matrix elements and alternative processes is given.

  7. [High beta tokamak research

    International Nuclear Information System (INIS)

    Our activities on High Beta Tokamak Research during the past 20 months of the present grant period can be divided into six areas: reconstruction and modeling of high beta equilibria in HBT; measurement and analysis of MHD instabilities observed in HBT; measurements of impurity transport; diagnostic development on HBT; numerical parameterization of the second stability regime; and conceptual design and assembly of HBT-EP. Each of these is described in some detail in the sections of this progress report

  8. High beta multipoles

    International Nuclear Information System (INIS)

    Multipoles are being employed as devices to study fusion issues and plasma phenomena at high values of beta (plasma pressure/magnetic pressure) in a controlled manner. Due to their large volume, low magnetic field (low synchrotron radiation) region, they are also under consideration as potential steady state advanced fuel (low neutron yield) reactors. Present experiments are investigating neoclassical (bootstrap and Pfirsch-Schlueter) currents and plasma stability at extremely high beta

  9. Autoregressive conditional beta

    OpenAIRE

    Yunmi Kim

    2012-01-01

    The capital asset pricing model provides various predictions about equilibrium expected returns on risky assets. One key prediction is that the risk premium on a risky asset is proportional to the nondiversifiable market risk measured by the asset's beta coefficient. This paper proposes a new method for estimating and drawing inferences from a time-varying capital asset pricing model. The proposed method, which can be considered a vector autoregressive model for multiple beta coefficients, is...

  10. Double beta decay experiments

    International Nuclear Information System (INIS)

    The great sensitivity of double beta decay to neutrino mass and right handed currents has motivated many new and exciting attempts to observe this elusive nuclear phenomenon directly. Experiments in operation and other coming on line in the next one or two years are expected to result in order-of-magnitude improvements in detectable half lives for both the two-neutrino and no-neutrino modes. A brief history of double beta decay experiments is presented together with a discussion of current experimental efforts, including a gas filled time projection chamber being used to study selenium-82. (author)

  11. Plasma beta HCG determination

    International Nuclear Information System (INIS)

    There are three important indications for the early diagnosis of pregnancy through the determination of the beta sub-unit of chorionic gonadotrophin using radioimmunoassay: 1) some patient's or doctor's anxiety to discover the problem; 2) when it will be necessary to employ diagnostic or treatment procedures susceptible to affect the ovum; and 3) in the differential diagnosis of amenorrhoea, uterine hemorrhage and abdominal tumors. Other user's are the diagnosis of missed absortion, and the diagnosis and follow-up of chrorioncarcinoma. The AA. studied 200 determinations of plasma beta-HCG, considering the main difficulties occuring in the clinical use of this relevant laboratory tool in actual Obstetrics. (author)

  12. Beta and Gamma Gradients

    DEFF Research Database (Denmark)

    Løvborg, Leif; Gaffney, C. F.; Clark, P. A.;

    1985-01-01

    Experimental and/or theoretical estimates are presented concerning, (i) attenuation within the sample of beta and gamma radiation from the soil, (ii) the gamma dose within the sample due to its own radioactivity, and (iii) the soil gamma dose in the proximity of boundaries between regions of...... differing radioactivity. It is confirmed that removal of the outer 2 mm of sample is adequate to remove influence from soil beta dose and estimates are made of the error introduced by non-removal. Other evaluations include variation of the soil gamma dose near the ground surface and it appears that the...

  13. Evaluation of neutrino masses from $m_{\\beta\\beta}$ values

    CERN Document Server

    Khrushchov, V V

    2008-01-01

    A neutrino mass matrix is considered under conditions of the CP invariance and the negligible reactor mixing $\\theta_{13}$ angle. Absolute mass values for three neutrinos are evaluated in normal and inverted hierarchy spectra on the ground of data for oscillation mixing neutrino parameters and effective neutrino mass entering into a probability of neutrinoless two beta decay $m_{\\beta\\beta}$ values.

  14. Low-beta structures

    OpenAIRE

    M. Vretenar(CERN, Geneva, Switzerland)

    2012-01-01

    'Low-beta' radio-frequency accelerating structures are used in the sections of a linear accelerator where the velocity of the particle beam increases with energy. The requirement for space periodicity to match the increasing particle velocity led to the development of a large variety of structures, both normal and superconducting, which are described in this lecture.

  15. Applied Beta Dosimetry

    Energy Technology Data Exchange (ETDEWEB)

    Rich, B.L.

    1986-01-01

    Measurements of beta and/or nonpenetrating exposure results is complicated and past techniques and capabilities have resulted in significant inaccuracies in recorded results. Current developments have resulted in increased capabilities which make the results more accurate and should result in less total exposure to the work force. Continued development of works in progress should provide equivalent future improvements.

  16. Roughing up Beta

    DEFF Research Database (Denmark)

    Bollerslev, Tim; Li, Sophia Zhengzi; Todorov, Viktor

    Motivated by the implications from a stylized equilibrium pricing framework, we investigate empirically how individual equity prices respond to continuous, or \\smooth," and jumpy, or \\rough," market price moves, and how these different market price risks, or betas, are priced in the cross-section...

  17. Neutrinoless Double Beta Decay

    CERN Document Server

    Päs, Heinrich

    2015-01-01

    We review the potential to probe new physics with neutrinoless double beta decay $(A,Z) \\to (A,Z+2) + 2 e^-$. Both the standard long-range light neutrino mechanism as well as short-range mechanisms mediated by heavy particles are discussed. We also stress aspects of the connection to lepton number violation at colliders and the implications for baryogenesis.

  18. Applied Beta Dosimetry

    International Nuclear Information System (INIS)

    Measurements of beta and/or nonpenetrating exposure results is complicated and past techniques and capabilities have resulted in significant inaccuracies in recorded results. Current developments have resulted in increased capabilities which make the results more accurate and should result in less total exposure to the work force. Continued development of works in progress should provide equivalent future improvements

  19. Interferon Beta-1b Injection

    Science.gov (United States)

    Interferon beta-1b injection is used to reduce episodes of symptoms in patients with relapsing-remitting (course ... and problems with vision, speech, and bladder control). Interferon beta-1b is in a class of medications ...

  20. Genetics Home Reference: beta thalassemia

    Science.gov (United States)

    ... for Disease Control and Prevention Centre for Genetics Education (Australia) Cold Spring Harbor Laboratory: Your Genes Your Health Disease InfoSearch: Beta Thalassemia Genomics Education Programme (UK) MalaCards: dominant beta-thalassemia Merck Manual ...

  1. Beta gets better with age

    OpenAIRE

    Tomunen, Tuomas

    2015-01-01

    The objective of my thesis is to study the cause for the low beta anomaly, which is an observation that the high beta stocks perform poorly relative to the low beta stocks. Based on earlier findings, I hypothesize that if a stock has high investor attention, its price overreacts to market-wide shocks, which results in a positive measurement error in its beta. Simultaneously, high attention causes overpricing, because the stock overreacts more often to positive shocks than to negat...

  2. Misleading Betas: An Educational Example

    Science.gov (United States)

    Chong, James; Halcoussis, Dennis; Phillips, G. Michael

    2012-01-01

    The dual-beta model is a generalization of the CAPM model. In the dual-beta model, separate beta estimates are provided for up-market and down-market days. This paper uses the historical "Anscombe quartet" results which illustrated how very different datasets can produce the same regression coefficients to motivate a discussion of the…

  3. Beta-thalassemia

    Directory of Open Access Journals (Sweden)

    Origa Raffaella

    2010-05-01

    Full Text Available Abstract Beta-thalassemias are a group of hereditary blood disorders characterized by anomalies in the synthesis of the beta chains of hemoglobin resulting in variable phenotypes ranging from severe anemia to clinically asymptomatic individuals. The total annual incidence of symptomatic individuals is estimated at 1 in 100,000 throughout the world and 1 in 10,000 people in the European Union. Three main forms have been described: thalassemia major, thalassemia intermedia and thalassemia minor. Individuals with thalassemia major usually present within the first two years of life with severe anemia, requiring regular red blood cell (RBC transfusions. Findings in untreated or poorly transfused individuals with thalassemia major, as seen in some developing countries, are growth retardation, pallor, jaundice, poor musculature, hepatosplenomegaly, leg ulcers, development of masses from extramedullary hematopoiesis, and skeletal changes that result from expansion of the bone marrow. Regular transfusion therapy leads to iron overload-related complications including endocrine complication (growth retardation, failure of sexual maturation, diabetes mellitus, and insufficiency of the parathyroid, thyroid, pituitary, and less commonly, adrenal glands, dilated myocardiopathy, liver fibrosis and cirrhosis. Patients with thalassemia intermedia present later in life with moderate anemia and do not require regular transfusions. Main clinical features in these patients are hypertrophy of erythroid marrow with medullary and extramedullary hematopoiesis and its complications (osteoporosis, masses of erythropoietic tissue that primarily affect the spleen, liver, lymph nodes, chest and spine, and bone deformities and typical facial changes, gallstones, painful leg ulcers and increased predisposition to thrombosis. Thalassemia minor is clinically asymptomatic but some subjects may have moderate anemia. Beta-thalassemias are caused by point mutations or, more rarely

  4. Beta and muon decays

    International Nuclear Information System (INIS)

    These notes represent a series of lectures delivered by the authors in the Junta de Energia Nuclear, during the Spring term of 1965. They were devoted to graduate students interested in the Theory of Elementary Particles. Special emphasis was focussed into the computational problems. Chapter I is a review of basic principles (Dirac equation, transition probabilities, final state interactions.) which will be needed later. In Chapter II the four-fermion punctual Interaction is discussed, Chapter III is devoted to the study of beta-decay; the main emphasis is given to the deduction of the formulae corresponding to electron-antineutrino correlation, electron energy spectrum, lifetimes, asymmetry of electrons emitted from polarized nuclei, electron and neutrino polarization and time reversal invariance in beta decay. In Chapter IV we deal with the decay of polarized muons with radiative corrections. Chapter V is devoted to an introduction to C.V.C. theory. (Author)

  5. Integration of BETA with Eclipse

    DEFF Research Database (Denmark)

    Andersen, Peter; Madsen, Ole Lehrmann; Enevoldsen, Mads Brøgger

    2004-01-01

    This paper presents language interoperability issues appearing in order to implement support for the BETA language in the Java-based Eclipse integrated development environment. One of the challenges is to implement plug-ins in BETA and be able to load them in Eclipse. In order to do this, some form...... of language interoperability between Java and BETA is required. The first approach is to use the Java Native Interface and use C to bridge between Java and BETA. This results in a workable, but complicated solution. The second approach is to let the BETA compiler generate Java class files. With this...... approach it is possible to implement plug-ins in BETA and even inherit from Java classes. In the paper the two approaches are described together with part of the mapping from BETA to Java class files. http://www.sciencedirect.com/science/journal/15710661...

  6. COM Support in BETA

    DEFF Research Database (Denmark)

    Madsen, Ole Lehrmann

    1999-01-01

    Component technologies based on binary units of independent production are some of the most important contributions to software architecture and reuse during recent years. Especially the COM technologies and the CORBA standard from the Object Management Group have contributed new and interesting ...... principles for software architecture, and proven to be useful in parctice. In this paper ongoing work with component support in the BETA language is described....

  7. Beta decay for pedestrians

    CERN Document Server

    Lipkin, Harry Jeannot

    1962-01-01

    The ""pedestrian approach"" was developed to describe some essentially simple experimental results and their theoretical implications in plain language. In this graduate-level text, Harry J. Lipkin presents simply, but without oversimplification, the aspects of beta decay that can be understood without reference to the formal theory; that is, the reactions that follow directly from conservation laws and elementary quantum mechanics.The pedestrian treatment is neither a substitute for a complete treatment nor a watered-down version.

  8. LHCb: $2\\beta_s$ measurement at LHCb

    CERN Multimedia

    Conti, G

    2009-01-01

    A measurement of $2\\beta_s$, the phase of the $B_s-\\bar{B_s}$ oscillation amplitude with respect to that of the ${\\rm b} \\rightarrow {\\rm c^{+}}{\\rm W^{-}}$ tree decay amplitude, is one of the key goals of the LHCb experiment with first data. In the Standard Model (SM), $2\\beta_s$ is predicted to be $0.0360^{+0.0020}_{-0.0016} \\rm rad$. The current constraints from the Tevatron are: $2\\beta_{s}\\in[0.32 ; 2.82]$ at 68$\\%$CL from the CDF experiment and $2\\beta_{s}=0.57^{+0.24}_{-0.30}$ from the D$\\oslash$ experiment. Although the statistical uncertainties are large, these results hint at the possible contribution of New Physics in the $B_s-\\bar{B_s}$ box diagram. After one year of data taking at LHCb at an average luminosity of $\\mathcal{L}\\sim2\\cdot10^{32}\\rm cm^{-2} \\rm s^{-1}$ (integrated luminosity $\\mathcal{L}_{\\rm int}\\sim 2 \\rm fb^{-1}$), the expected statistical uncertainty on the measurement is $\\sigma(2\\beta_s)\\simeq 0.03$. This uncertainty is similar to the $2\\beta_s$ value predicted by the SM.

  9. Xeroradiography in. beta. -thalassaemia

    Energy Technology Data Exchange (ETDEWEB)

    Scutellari, P.N.; Orzincolo, C.; Tamarozzi, R.

    1985-01-01

    Xeroradiographic investigations of the skull, hand, and elbow were performed on 27 patients with homozygous ..beta..-thalassaemia. The results were compared with plain radiographic examinations. Xeroradiography, because of its technical properties (i.e. edge contrast enhancement and wide latitude), was shown to demonstrate cortical thinning of long bones, swelling of the diploic space in the skull, and reticulated patterns in the elbow better than standard radiography. Moreover, the use of 'positive' mode imaging was shown to have advantages in the study of the skull and extremities.

  10. Realized Beta GARCH

    DEFF Research Database (Denmark)

    Hansen, Peter Reinhard; Lunde, Asger; Voev, Valeri Radkov

    2014-01-01

    particularly useful for modeling financial returns during periods of rapid changes in the underlying covariance structure. When applied to market returns in conjunction with returns on an individual asset, the model yields a dynamic model specification of the conditional regression coefficient that is known as...... conditional beta series during the financial crises.......We introduce a multivariate generalized autoregressive conditional heteroskedasticity (GARCH) model that incorporates realized measures of variances and covariances. Realized measures extract information about the current levels of volatilities and correlations from high-frequency data, which is...

  11. Double beta decay: present status

    OpenAIRE

    Barabash, A. S.

    2008-01-01

    The present status of double beta decay experiments (including the search for $2\\beta^{+}$, EC$\\beta^{+}$ and ECEC processes) are reviewed. The results of the most sensitive experiments are discussed. Average and recommended half-life values for two-neutrino double beta decay are presented. Conservative upper limits on effective Majorana neutrino mass and the coupling constant of the Majoron to the neutrino are established as $ < 0.75$ eV and $ < 1.9 \\cdot 10^{-4}$, respectively. Proposals fo...

  12. Simultaneous beta and gamma spectroscopy

    Science.gov (United States)

    Farsoni, Abdollah T.; Hamby, David M.

    2010-03-23

    A phoswich radiation detector for simultaneous spectroscopy of beta rays and gamma rays includes three scintillators with different decay time characteristics. Two of the three scintillators are used for beta detection and the third scintillator is used for gamma detection. A pulse induced by an interaction of radiation with the detector is digitally analyzed to classify the type of event as beta, gamma, or unknown. A pulse is classified as a beta event if the pulse originated from just the first scintillator alone or from just the first and the second scintillator. A pulse from just the third scintillator is recorded as gamma event. Other pulses are rejected as unknown events.

  13. Scintillator based beta batteries

    Science.gov (United States)

    Rensing, Noa M.; Tiernan, Timothy C.; Shirwadkar, Urmila; O'Dougherty, Patrick; Freed, Sara; Hawrami, Rastgo; Squillante, Michael R.

    2013-05-01

    Some long-term, remote applications do not have access to conventional harvestable energy in the form of solar radiation (or other ambient light), wind, environmental vibration, or wave motion. Radiation Monitoring Devices, Inc. (RMD) is carrying out research to address the most challenging applications that need power for many months or years and which have undependable or no access to environmental energy. Radioisotopes are an attractive candidate for this energy source, as they can offer a very high energy density combined with a long lifetime. Both large scale nuclear power plants and radiothermal generators are based on converting nuclear energy to heat, but do not scale well to small sizes. Furthermore, thermo-mechanical power plants depend on moving parts, and RTG's suffer from low efficiency. To address the need for compact nuclear power devices, RMD is developing a novel beta battery, in which the beta emissions from a radioisotope are converted to visible light in a scintillator and then the visible light is converted to electrical power in a photodiode. By incorporating 90Sr into the scintillator SrI2 and coupling the material to a wavelength-matched solar cell, we will create a scalable, compact power source capable of supplying milliwatts to several watts of power over a period of up to 30 years. We will present the latest results of radiation damage studies and materials processing development efforts, and discuss how these factors interact to set the operating life and energy density of the device.

  14. BETA SPECTRA. I. Negatrons spectra

    International Nuclear Information System (INIS)

    Using the Fermi theory of beta decay, the beta spectra for 62 negatrons emitters have been computed introducing a correction factor for unique forbidden transitions. These spectra are plotted vs. energy, once normal i sed, and tabulated with the related Fermi functions. The average and median energies are calculated. (Author)

  15. The best-beta CAPM

    NARCIS (Netherlands)

    L. Zou

    2006-01-01

    The issue of 'best-beta' arises as soon as potential errors in the Sharpe-Lintner-Black capital asset pricing model (CAPM) are acknowledged. By incorporating a target variable into the investor preferences, this study derives a best-beta CAPM (BCAPM) that maintains the CAPM's theoretical appeal and

  16. RAVEN Beta Release

    Energy Technology Data Exchange (ETDEWEB)

    Rabiti, Cristian [Idaho National Lab. (INL), Idaho Falls, ID (United States); Alfonsi, Andrea [Idaho National Lab. (INL), Idaho Falls, ID (United States); Cogliati, Joshua Joseph [Idaho National Lab. (INL), Idaho Falls, ID (United States); Mandelli, Diego [Idaho National Lab. (INL), Idaho Falls, ID (United States); Kinoshita, Robert Arthur [Idaho National Lab. (INL), Idaho Falls, ID (United States); Wang, Congjian [Idaho National Lab. (INL), Idaho Falls, ID (United States); Maljovec, Daniel Patrick [Idaho National Lab. (INL), Idaho Falls, ID (United States); Talbot, Paul William [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-02-01

    This documents the release of the Risk Analysis Virtual Environment (RAVEN) code. A description of the RAVEN code is provided, and discussion of the release process for the M2LW-16IN0704045 milestone. The RAVEN code is a generic software framework to perform parametric and probabilistic analysis based on the response of complex system codes. RAVEN is capable of investigating the system response as well as the input space using Monte Carlo, Grid, or Latin Hyper Cube sampling schemes, but its strength is focused toward system feature discovery, such as limit surfaces, separating regions of the input space leading to system failure, using dynamic supervised learning techniques. RAVEN has now increased in maturity enough for the Beta 1.0 release.

  17. RAVEN Beta Release

    International Nuclear Information System (INIS)

    This documents the release of the Risk Analysis Virtual Environment (RAVEN) code. A description of the RAVEN code is provided, and discussion of the release process for the M2LW-16IN0704045 milestone. The RAVEN code is a generic software framework to perform parametric and probabilistic analysis based on the response of complex system codes. RAVEN is capable of investigating the system response as well as the input space using Monte Carlo, Grid, or Latin Hyper Cube sampling schemes, but its strength is focused toward system feature discovery, such as limit surfaces, separating regions of the input space leading to system failure, using dynamic supervised learning techniques. RAVEN has now increased in maturity enough for the Beta 1.0 release.

  18. Beta Beams Implementation at CERN

    CERN Document Server

    Hansen, Christian

    2011-01-01

    Beta Beam,the concept of generating a pure and intense (anti) neutrino beam by letting accelerated radioactive ions beta decay in a storage ring, called Decay Ring (DR), is the base of one of the proposed next generation neutrino oscillation facilities, necessary for a complete study of the neutrino oscillation parameter space. Sensitivities of the unknown neutrino oscillation parameters depend on the Decay Ring's ion intensity and of it's duty factor (the filled ratio of the ring). Therefore efficient ion production, stripping, bunching, acceleration and storing are crucial sub-projects under study and development within the Beta Beam collaboration. Specifically the feasibility of these tasks as parts of a Beta Beam implementation at CERN will be discussed in this report. The positive impact of the large {\\theta}13 indications from T2K on the Beta Beam performance will also be discussed.

  19. Intuitionistic Fuzzy Generalized Beta Closed Mappings

    OpenAIRE

    D. Jayanthi

    2014-01-01

    In this paper we introduce intuitionistic fuzzy generalized beta closed mappings and intuitionistic fuzzy generalized beta open mappings. We investigate some of their properties. We also introduce intuitionistic fuzzy M-generalized beta closed mappings as well as intuitionistic fuzzy M-generalized beta open mappings. We provide the relation between intuitionistic fuzzy M-generalized beta closed mappings and intuitionistic fuzzy generalized beta closed mappings.

  20. Derivatives of the Incomplete Beta Function

    Directory of Open Access Journals (Sweden)

    Robert J. Boik

    1998-03-01

    Full Text Available The incomplete beta function is defined as where Beta(p, q is the beta function. Dutka (1981 gave a history of the development and numerical evaluation of this function. In this article, an algorithm for computing first and second derivatives of Ix,p,q with respect to p and q is described. The algorithm is useful, for example, when fitting parameters to a censored beta, truncated beta, or a truncated beta-binomial model.

  1. Derivatives of the Incomplete Beta Function

    OpenAIRE

    Robison-Cox, James F.; Robert J. Boik

    1998-01-01

    The incomplete beta function is defined as where Beta(p, q) is the beta function. Dutka (1981) gave a history of the development and numerical evaluation of this function. In this article, an algorithm for computing first and second derivatives of Ix,p,q with respect to p and q is described. The algorithm is useful, for example, when fitting parameters to a censored beta, truncated beta, or a truncated beta-binomial model.

  2. High Temperature Stability of Potassium Beta Alumina

    Science.gov (United States)

    Williams, R. M.; Kisor, A.; Ryan, M. A.

    1996-01-01

    None. From Objectives section: Evaluate the stability of potassium beta alumina under potassium AMTEC operating conditions. Evaluate the stability regime in which potassium beta alumina can be fabricated.

  3. A semiconductor beta ray spectrometer

    International Nuclear Information System (INIS)

    Measurement of energy spectra of beta particles emitted from nuclei in beta-decay processes provides information concerning the mass difference of these nuclei between initial and final state. Moreover, experimental beta spectra yield information on the feeding of the levels in the daughter nucleus. Such data are valuable in the construction and checking of the level schemes. This thesis describes the design, construction, testing and usage of a detector for the accurate measurement of the mentioned spectra. In ch. 2 the design and construction of the beta spectrometer, which uses a hyper-pure germanium crystal for energy determination, is described. A simple wire chamber is used to discriminate beta particles from gamma radiation. Disadvantages arise from the large amounts of scattered beta particles deforming the continua. A method is described to minimize the scattering. In ch. 3 some theoretical aspects of data analysis are described and the results of Monte-Carlo simulations of the summation of annihilation radiation are compared with experiments. Ch. 4 comprises the results of the measurements of the beta decay energies of 103-108In. 87 refs.; 34 figs.; 7 tabs

  4. Effect of beta blockade and beta stimulation on stage fright.

    Science.gov (United States)

    Brantigan, C O; Brantigan, T A; Joseph, N

    1982-01-01

    Stage fright, physiologically the "fight or flight" reaction, is a disabling condition to the professional musician. Because it is mediated by the sympathetic nervous system, we have investigated the effects of beta blockade on musical performance with propranolol in a double blind fashion and the effects of beta stimulation using terbutaline. Stage fright symptoms were evaluated in two trials, which included a total of 29 subjects, by questionnaire and by the State Trai Anxiety Inventory. Quality of musical performance was evaluated by experienced music critics. Beta blockade eliminates the physical impediments to performance caused by stage fright and even eliminates the dry mouth so frequently encountered. The quality of musical performance as judged by experienced music critics is significantly improved. This effect is achieved without tranquilization. Beta stimulating drugs increase stage fright problems, and should be used in performing musicians only after consideration of the detrimental effects which they may have on musical performance. PMID:6120650

  5. Beta decay of 31Ar

    International Nuclear Information System (INIS)

    A complete study of 31Ar beta decay has been made by high-resolution charged-particle and gamma-ray spectroscopy. Beta-delayed radiation was detected by an array of three charged-particle detectors and a large-volume germanium detector. Fifteen new energy levels were discovered in 31Cl. The beta-strength distribution, measured to 14.5 MeV, is compared with a shell-model calculation in the full sd space. The quenching of the Gamow-Teller strength and the isospin impurity of the IAS in 31Cl are discussed. (orig.)

  6. The Age of Beta Pic

    OpenAIRE

    Navascues, D. Barrado y; Stauffer, J. R.; Song, I.; Caillault, J-P.

    1999-01-01

    We have reanalyzed data for the proposed moving group associated with beta Pic in order to determine if the group (or part of it) is real, and, if so, to derive an improved age estimate for beta Pic. By using new, more accurate proper motions from PPM and Hipparcos and a few new radial velocities, we conclude that on kinematic grounds, two M dwarfs have space motions that coincide with that of beta Pic to within 1 km/s with small error bars. Based on a CM diagram derived from accurate photome...

  7. Smart Beta or Smart Alpha

    DEFF Research Database (Denmark)

    Winther, Kenneth Lillelund; Steenstrup, Søren Resen

    2016-01-01

    that smart beta investing probably will do better than passive market capitalization investing over time, we believe many are coming to a conclusion too quickly regarding active managers. Institutional investors are able to guide managers through benchmarks and risk frameworks toward the same well...... only superior to the common capitalization weighted index but also to their smart beta benchmark, even after cost for value, size, and low volatility funds. We encourage investors to increase the use of smart beta as benchmarks while still obtaining extra performance through active management—a concept...

  8. Experiments on double beta decay

    Energy Technology Data Exchange (ETDEWEB)

    Busto, J. [Neuchatel Univ. (Switzerland). Inst. de Physique

    1996-11-01

    The Double Beta Decay, and especially ({beta}{beta}){sub 0{nu}} mode, is an excellent test of Standard Model as well as of neutrino physics. From experimental point of view, a very large number of different techniques are or have been used increasing the sensitivity of this experiments quite a lot (the factor of 10{sup 4} in the last 20 years). In future, in spite of several difficulties, the sensitivity would be increased further, keeping the interest of this very important process. (author) 4 figs., 5 tabs., 21 refs.

  9. Dosimetry of {beta} extensive sources; Dosimetria de fuentes {beta} extensas

    Energy Technology Data Exchange (ETDEWEB)

    Rojas C, E.L.; Lallena R, A.M. [Departamento de Fisica Moderna, Universidad de Granada, E-18071 Granada (Spain)

    2002-07-01

    In this work, we have been studied, making use of the Penelope Monte Carlo simulation code, the dosimetry of {beta} extensive sources in situations of spherical geometry including interfaces. These configurations are of interest in the treatment of the called cranealfaringyomes of some synovia leisure of knee and other problems of interest in medical physics. Therefore, its application can be extended toward problems of another areas with similar geometric situation and beta sources. (Author)

  10. Resistance training & beta-hydroxy-beta-methylbutyrate supplementation on hormones

    OpenAIRE

    Hamid Arazi; Hadi Rohani; Ahmad Ghiasi; Nasrin Abdi Keikanloo

    2015-01-01

    RESUMOIntroduction:In recent years, there was an increased interest on the effects of beta-hydroxy-beta-methylbutyrate (HMB) supplementation on skeletal muscle due to its anti-catabolic effects.Objectives:To investigate the effect of HMB supplementation on body composition, muscular strength and anabolic-catabolic hormones after resistance training.Methods:Twenty amateur male athletes were randomly assigned to supplement and control groups in a double-blind crossover design and participated i...

  11. Beta particle monitor for surfaces

    International Nuclear Information System (INIS)

    A beta radiation detector which is capable of reliably detecting beta radiation emitted from a surface. An electrically conductive signal collector is adjustably mounted inside an electrically conductive enclosure which may define a single large opening for placing against a surface. The adjustable mounting of the electrically conductive signal collector can be based on the distance from the surface or on the expected beta energy range. A voltage source is connected to the signal collector through an electrometer or other display means for creating an electric field between the signal collector and the enclosure. Air ions created by the beta radiation are collected and the current produced is indicated on the electrometer or other display means. 2 figs

  12. Peginterferon Beta-1a Injection

    Science.gov (United States)

    ... symptoms such as headaches, bone or muscle aches, fever, chills, and tiredness during your treatment with peginterferon beta- ... not go away: headache muscle or joint pain fever chills weakness Some side effects can be serious. If ...

  13. Beta-gamma discriminator circuit

    International Nuclear Information System (INIS)

    The major difficulty encountered in the determination of beta-ray dose in field conditions is generally the presence of a relatively high gamma-ray component. Conventional dosimetry instruments use a shield on the detector to estimate the gamma-ray component in comparison with the beta-ray component. More accurate dosimetry information can be obtained from the measured beta spectrum itself. At Los Alamos, a detector and discriminator circuit suitable for use in a portable spectrometer have been developed. This instrument will discriminate between gammas and betas in a mixed field. The portable package includes a 256-channel MCA which can be programmed to give a variety of outputs, including a spectral display, and may be programmed to read dose directly

  14. Recent double beta decay results

    Energy Technology Data Exchange (ETDEWEB)

    Balysh, A. (Kurchatov Institute, 123 182 Moscow (Russian Federation)); Beck, M. (Max-Planck-Institut fuer Kernphysik, W-6900 Heidelberg (Germany)); Belyaev, S.T. (Kurchatov Institute, 123 182 Moscow (Russian Federation)); Bensch, F.; Bockholt, J. (Max-Planck-Institut fuer Kernphysik, W-6900 Heidelberg (Germany)); Demehin, A.; Gurov, A. (Kurchatov Institute, 123 182 Moscow (Russian Federation)); Heusser, G.; Hirsch, M.; Klapdor-Kleingrothaus, H.V. (Max-Planck-Institut fuer Kernphysik, W-6900 Heidelberg (Germany)); Kondratenko, I.; Lebedev, V.I. (Kurchatov Institute, 123 182 Moscow (Russian Federation)); Maier, B. (Max-Planck-Institut fuer Kernphysik, W-6900 Heidelberg (Germany)); Mueller, A. (Istituto Nazionale di Fisica Nucleare LNGS, 67010 Assergi (Italy)); Petry, F.; Piepke, A.; Strecker, H.; Voellinger, M.; Zuber, K. (Max-Planck-Institut fuer Kernphysik, W-6900 Heidelberg (Germany))

    1992-02-01

    The status and recent results of second generation [beta][beta]-experiments using isotopically enriched source materials are described. These experiments are at present the most sensitive tools to distinguish Dirac from Majorana neutrinos. The at present most advanced experimental techniques, namely the use of high-resolution calorimetric detectors and of time projection chambers are compared. New limits on the Majorana neutrino mass as well as for the Majoron-neutrino coupling are presented.

  15. Apollo applications of beta fiber glass

    Science.gov (United States)

    Naimer, J.

    1971-01-01

    The physical characteristics of Beta fiber glass are discussed. The application of Beta fiber glass for fireproofing the interior of spacecraft compartments is described. Tests to determine the flammability of Beta fiber glass are presented. The application of Beta fiber glass for commercial purposes is examined.

  16. Synthesis of Beta Pyridyl Carbinol Tartrate

    Directory of Open Access Journals (Sweden)

    S. K. Shukla

    1968-04-01

    Full Text Available A process for the synthesis of Beta pyridine carboxylic acid ethy1 ester starting from quinoline has been developed. Beta-pyridine carboxylic acid ethy1 ester on reduction with lithium aluminium hydride gave Beta-pyridy1 carbinol which on treatment tartaric acid yielded Beta-pyridy1 carbinol tartrate, a vaso dilator known in trade as "Ronicoltartrate".

  17. Vasodilatory mechanisms of beta receptor blockade.

    OpenAIRE

    Rath, Géraldine; Balligand, Jean-Luc; Dessy, Chantal

    2012-01-01

    Beta-blockers are widely prescribed for the treatment of a variety of cardiovascular pathologies. Compared to traditional beta-adrenergic antagonists, beta-blockers of the new generation exhibit ancillary properties such as vasodilation through different mechanisms. This translates into a more favorable hemodynamic profile. The relative affinities of beta-adrenoreceptor antagonists towards the three beta-adrenoreceptor isotypes matter for predicting their functional impact on vasomotor contro...

  18. Tables of double beta decay data

    Energy Technology Data Exchange (ETDEWEB)

    Tretyak, V.I. [AN Ukrainskoj SSR, Kiev (Ukraine)]|[Strasbourg-1 Univ., 67 (France). Centre de Recherches Nucleaires; Zdesenko, Y.G. [AN Ukrainskoj SSR, Kiev (Ukraine)

    1995-12-31

    A compilation of experimental data on double beta decay is presented. The tables contain the most stringent known experimental limits or positive results of 2{beta} transitions of 69 natural nuclides to ground and excited states of daughter nuclei for different channels (2{beta}{sup -}; 2{beta}{sup +}; {epsilon}{beta}{sup +}; 2{epsilon}) and modes (0{nu}; 2{nu}; 0{nu}M) of decay. (authors). 189 refs., 9 figs., 3 tabs.

  19. Beta contamination monitor energy response

    International Nuclear Information System (INIS)

    Beta contamination is monitored at Los Alamos National Laboratory (LANL) with portable handheld probes and their associated counters, smear counters, air-breathing continuous air monitors (CAM), personnel contamination monitors (PCM), and hand and foot monitors (HFM). The response of these monitors was measured using a set of anodized-aluminum beta sources for the five isotopes: Carbon-14, Technetium-99, Cesium-137, Chlorine-36 and Strontium/Yttrium-90. The surface emission rates of the sources are traceable to the National Institute of Standards and Technology (NIST) with a precision of one relative standard deviation equal to 1.7%. All measurements were made in reproducible geometry, mostly using aluminum source holders. All counts, significantly above background, were collected to a precision of 1% or better. The study of the hand-held probes included measurements of six air gaps from 0.76 to 26.2 mm. The energy response of the detectors is well-parameterized as a function of the average beta energy of the isotopes (C14=50 keV, Tc99=85, Cs137=188, C136=246, and Sr/Y90=934). The authors conclude that Chlorine-36 is a suitable beta emitter for routine calibration. They recommend that a pancake Geiger-Mueller (GM) or gas-proportional counter be used for primarily beta contamination surveys with an air gap not to exceed 6 mm. Energy response varies about 30% from Tc99 to Sr/Y90 for the pancake GM detector. Dual alpha/beta probes have poor to negligible efficiency for low-energy betas. The rugged anodized sources represent partially imbedded contamination found in the field and they are provided with precise, NIST-traceable, emission rates for reliable calibration

  20. In-trap decay spectroscopy for {beta}{beta} decays

    Energy Technology Data Exchange (ETDEWEB)

    Brunner, Thomas

    2011-01-18

    The presented work describes the implementation of a new technique to measure electron-capture (EC) branching ratios (BRs) of intermediate nuclei in {beta}{beta} decays. This technique has been developed at TRIUMF in Vancouver, Canada. It facilitates one of TRIUMF's Ion Traps for Atomic and Nuclear science (TITAN), the Electron Beam Ion Trap (EBIT) that is used as a spectroscopy Penning trap. Radioactive ions, produced at the radioactive isotope facility ISAC, are injected and stored in the spectroscopy Penning trap while their decays are observed. A key feature of this technique is the use of a strong magnetic field, required for trapping. It radially confines electrons from {beta} decays along the trap axis while X-rays, following an EC, are emitted isotropically. This provides spatial separation of X-ray and {beta} detection with almost no {beta}-induced background at the X-ray detector, allowing weak EC branches to be measured. Furthermore, the combination of several traps allows one to isobarically clean the sample prior to the in-trap decay spectroscopy measurement. This technique has been developed to measure ECBRs of transition nuclei in {beta}{beta} decays. Detailed knowledge of these electron capture branches is crucial for a better understanding of the underlying nuclear physics in {beta}{beta} decays. These branches are typically of the order of 10{sup -5} and therefore difficult to measure. Conventional measurements suffer from isobaric contamination and a dominating {beta} background at theX-ray detector. Additionally, X-rays are attenuated by the material where the radioactive sample is implanted. To overcome these limitations, the technique of in-trap decay spectroscopy has been developed. In this work, the EBIT was connected to the TITAN beam line and has been commissioned. Using the developed beam diagnostics, ions were injected into the Penning trap and systematic studies on injection and storage optimization were performed. Furthermore, Ge

  1. Cardiac glycoside-like structure and function of 5 beta,14 beta-pregnanes

    International Nuclear Information System (INIS)

    5 beta-Reduction and 14 beta-substitution convert the planar progesterone molecule to the cardiac glycoside configuration--A and D rings of the steroid moiety are bent toward the alpha-face relative to the B and C rings. Potency of the 5 beta,14 beta-derivative in a [3H]ouabain binding assay or its ability to inhibit the sodium pump in red blood cells is enhanced by 3 beta-hydroxylation, 20 beta-hydroxylation, and 3 beta-glycosidation. Synthesis of 14,20 beta-dihydroxy-3 beta-(beta-D-glucopyranosyloxy)- 5 beta,14 beta-pregnane from digitoxin is described. The glucoside is 1/20 as potent as ouabain and elicits prominent, sustained, positive inotropy in isolated cardiac muscle

  2. 50 years forward: beta cells.

    Science.gov (United States)

    Halban, Philippe A

    2015-08-01

    Our understanding of beta cell development and function has increased substantially these past 50 years but much remains to be learned before this knowledge can be put to clinical use. A comprehensive business plan will be necessary to develop a detailed molecular and functional blueprint of the beta cell in health and disease based on an integrated approach involving all necessary research disciplines. This blueprint will provide a platform for the development of novel therapeutic strategies for the treatment of both major forms of diabetes, foremost among them beta cell replacement therapy. This is one of a series of commentaries under the banner '50 years forward', giving personal opinions on future perspectives in diabetes, to celebrate the 50th anniversary of Diabetologia (1965-2015). PMID:25957776

  3. Predicting Neutrinoless Double Beta Decay

    CERN Document Server

    Hirsch, M; Valle, J W F; Moral, A V; Ma, Ernest

    2005-01-01

    We give predictions for the neutrinoless double beta decay rate in a simple variant of the A_4 family symmetry model. We show that there is a lower bound for the neutrinoless double beta decay amplitude even in the case of normal hierarchical neutrino masses, corresponding to an effective mass parameter |m_{ee}| >= 0.17 \\sqrt{\\Delta m^2_{ATM}}. This result holds both for the CP conserving and CP violating cases. In the latter case we show explicitly that the lower bound on |m_{ee}| is sensitive to the value of the Majorana phase. We conclude therefore that in our scheme, neutrinoless double beta decay may be accessible to the next generation of high sensitivity experiments.

  4. Mechanism of inactivation of alanine racemase by beta, beta, beta-trifluoroalanine

    International Nuclear Information System (INIS)

    The alanine racemases are a group of PLP-dependent bacterial enzymes that catalyze the racemization of alanine, providing D-alanine for cell wall synthesis. Inactivation of the alanine racemases from the Gram-negative organism Salmonella typhimurium and Gram-positive organism Bacillus stearothermophilus with beta, beta, beta-trifluoroalanine has been studied. The inactivation occurs with the same rate constant as that for formation of a broad 460-490-nm chromophore. Loss of two fluoride ions per mole of inactivated enzyme and retention of [1-14C]trifluoroalanine label accompany inhibition, suggesting a monofluoro enzyme adduct. Partial denaturation (1 M guanidine) leads to rapid return of the initial 420-nm chromophore, followed by a slower (t1/2 approximately 30 min-1 h) loss of the fluoride ion and 14CO2 release. At this point, reduction by NaB3H4 and tryptic digestion yield a single radiolabeled peptide. Purification and sequencing of the peptide reveals that lysine-38 is covalently attached to the PLP cofactor. A mechanism for enzyme inactivation by trifluoroalanine is proposed and contrasted with earlier results on monohaloalanines, in which nucleophilic attack of released aminoacrylate on the PLP aldimine leads to enzyme inactivation. For trifluoroalanine inactivation, nucleophilic attack of lysine-38 on the electrophilic beta-difluoro-alpha, beta-unsaturated imine provides an alternative mode of inhibition for these enzymes

  5. Constraining neutrinoless double beta decay

    International Nuclear Information System (INIS)

    A class of discrete flavor-symmetry-based models predicts constrained neutrino mass matrix schemes that lead to specific neutrino mass sum-rules (MSR). We show how these theories may constrain the absolute scale of neutrino mass, leading in most of the cases to a lower bound on the neutrinoless double beta decay effective amplitude.

  6. *608440 LACTAMASE, BETA; LACTB [OMIM

    Lifescience Database Archive (English)

    Full Text Available FIELD NO 608440 FIELD TI 608440 LACTAMASE, BETA; LACTB ;;MITOCHONDRIAL RIBOSOMAL PROTEIN L56; MR ... Chen et al. (2008) recorded weight, fat mass, and lean ... mass for Lpl heterozygous null mice, Lactb transge ... ifferent from those of controls, with the fat mass/lean ... mass ratio difference generally increasing over ti ...

  7. Monitor for alpha beta contamination of hands

    International Nuclear Information System (INIS)

    The following specifications of hands alpha beta contamination monitor are presented: the position of the hands, the detection and separation of alpha and beta, the information processing, the programming, the results presentation and general characteristics. (A.L.B.)

  8. How Do Beta Blocker Drugs Affect Exercise?

    Science.gov (United States)

    ... Stroke More How do beta blocker drugs affect exercise? Updated:Aug 5,2015 Beta blockers are a ... about them: Do they affect your ability to exercise? The answer can vary a great deal, depending ...

  9. Interferon Beta-1a Intramuscular Injection

    Science.gov (United States)

    Interferon beta-1a intramuscular injection is used to reduce the number of episodes of symptoms and slow ... and problems with vision, speech, and bladder control). Interferon beta-1a is in a class of medications ...

  10. Interferon Beta-1a Subcutaneous Injection

    Science.gov (United States)

    Interferon beta-1a subcutaneous injection is used to reduce episodes of symptoms and slow the development of ... and problems with vision, speech, and bladder control). Interferon beta-1a is in a class of medications ...

  11. The beta subunit of casein kinase II

    DEFF Research Database (Denmark)

    Boldyreff, B; Piontek, K; Schmidt-Spaniol, I; Issinger, O G

    1991-01-01

    cDNAs encoding the beta subunit of pig and mouse CKII were isolated. The porcine cDNA was expressed as a fusion protein in Escherichia coli and used for the production of anti-CKII-beta subunit specific antibodies.......cDNAs encoding the beta subunit of pig and mouse CKII were isolated. The porcine cDNA was expressed as a fusion protein in Escherichia coli and used for the production of anti-CKII-beta subunit specific antibodies....

  12. Beta adrenergic receptors in pigmented ciliary processes.

    OpenAIRE

    Trope, G. E.; Clark, B.

    1982-01-01

    Beta adrenergic receptors from membrane fragments of pigmented sheep eyes were studied and characterised by ligand binding techniques after the removal of melanin. In a representative experiment the beta max (total number of beta receptors) was 394.9 fmol/mg protein. The receptor affinity (Ka) was 440 pM. The potency series of drugs to displace 125I-HYP from the receptors was timolol = (-) propranolol greater than (+) propranolol greater than salbutamol greater than practolol. beta 1 Recepto...

  13. Theory of high-beta tokamaks

    International Nuclear Information System (INIS)

    The theoretical researches on high beta tokamak are reviewed. The ballooning mode instability is thought to be the most serious problem for the high beta tokamaks, and the theoretical results on the ballooning mode instability are discussed in detail. The experimental results in high beta belt pinch devices are also discussed. (author)

  14. Interferon Beta-1a Intramuscular Injection

    Science.gov (United States)

    Interferon beta-1a intramuscular injection is used to reduce the number of episodes of symptoms and slow the development of disability in patients ... Interferon beta-1a intramuscular injection comes as a powder in vials to be mixed into a solution for injection. Interferon beta-1a intramuscular ...

  15. Beta measurements at Department of Energy facilities

    International Nuclear Information System (INIS)

    Pacific Northwest Laboratory performed a two-step process to characterize the current beta measurement practices at DOE facilities. PNL issued a survey questionnaire on beta measurement practices to DOE facilities and reported the results. PNL measured beta doses and spectra at seven selected DOE facilities and compared selected measurement techniques in the facility environment. This report documents the results of the radiation field measurements and the comparison of measurement techniques at the seven facilities. Data collected included beta dose and spectral measurements at seven DOE facilities that had high beta-to-gamma ratios (using a silicon surface barrier spectrometer, a plastic scintillator spectrometer, and a multielement beta dosimeter). Other dosimeters and survey meters representative of those used at DOE facilities or under development were also used for comparison. Field spectra were obtained under two distinct conditions. Silicon- and scintillation-based spectrometer systems were used under laboratory conditions where high beta-to-gamma dose ratios made the beta spectra easier to observe and analyze. In the second case, beta spectrometers were taken into actual production and maintenance areas of DOE facilities. Analyses of beta and gamma spectra showed that 234Th- /sup 234m/Pa, 231Th, 137Cs, and 90Sr/90Y were the major nuclides contributing to beta doses at the facilities visited. Beta doses from other fission products and 60Co were also measured, but the potential for exposure was less significant. 21 refs., 64 figs., 18 tabs

  16. Measurement of the beta asymmetry in neutron beta decay

    International Nuclear Information System (INIS)

    Neutron beta decay is the simplest semi-leptonic weak decay and described accurately by the standard model using the first CKM-matrix element and the ratio of vector and axial vector couplings, λ. With more than a dozen observables it is a sensitive probe for investigating the nature of weak interaction and to search for physics beyond the standard model. In the past, measuring the beta asymmetry A in polarized neutron decay has been the most precise way of determining λ and nowadays it allows - together with other observables - to derive limits on non-standard model interactions, such as scalar and tensor couplings. The neutron decay spectrometer Perkeo III was installed at the PF1B cold neutron beam site at the Institut Laue-Langevin to measure the beta asymmetry. By using a pulsed beam combined with an improved detector design a significant reduction of several systematic uncertainties has been achieved compared to the predecessor, Perkeo II. In this talk recent results of the measurements with Perkeo III will be presented. In particular, we show the energy distribution of the electrons together with the calibration tools for the detectors.

  17. Beta thalassaemia mutations in Turkish Cypriots.

    OpenAIRE

    Sozuoz, A; Berkalp, A; A. Figus; Loi, A; Pirastu, M.; Cao, A

    1988-01-01

    Using oligonucleotide hybridisation or restriction endonuclease analysis, we have characterised the molecular defect in 94 patients with thalassaemia major and four with thalassaemia intermedia of Turkish Cypriot descent. We found that four mutations, namely beta+ IVS-1 nt 110, beta zero IVS-1 nt, beta+ IVS-1 nt 6, and beta+ IVS-2 nt 745 were prevalent, accounting for 69.9%, 11.7%, 8.7%, and 5.6% respectively of the beta thalassaemia chromosomes. This information may help in the organisation ...

  18. Plan beta: Core or Cusp?

    CERN Document Server

    Richardson, Thomas; Lehnert, Matt

    2013-01-01

    The inner profile of Dark Matter (DM) halos remains one of the central problems in small-scale cosmology. At present, the problem can not be resolved in dwarf spheroidal galaxies due to a degeneracy between the DM profile and the velocity anisotropy beta of the stellar population. We discuss a method which can break the degeneracy by exploiting 3D positions and 1D line-of-sight (LOS) velocities. With the full 3D spatial information, we can determine precisely what fraction of each stars LOS motion is in the radial and tangential direction. This enables us to infer the anisotropy parameter beta directly from the data. The method is particularly effective if the galaxy is highly anisotropic. Finally, we argue that such a test could be applied to Sagittarius and potentially other dwarfs with RR Lyrae providing the necessary depth information.

  19. Beta spectrum of 185W

    International Nuclear Information System (INIS)

    The measurement of the shape of the first forbidden beta transition of 185W is interesting from the point of view of the fact that this nucleus belongs to the deformed region 150185W is carried out employing an optimized Siegbahn-Slatis beta ray spectrometer and the result is compared with the theoretical shape factor incorporating Nilsson's wavefunctions using Simms formalism. The experimental shape factor is fitted to the correction factor C(W)=k(1+aW) with α=0.0026+-0.0432. The theoretical shape factor computed following the matrix elements due to Nilsson model is in good agreement with the present experimental shape factor. The value Λ(2.358) computed in the present measurement in the light of Nilsson model matrix elements of 185W is in agreement with the predicted value (2.4) of J.J. Fujita. (author)

  20. Abstraction Mechanisms in the BETA Programming Language

    DEFF Research Database (Denmark)

    Kristensen, Bent Bruun; Madsen, Ole Lehrmann; Møller-Pedersen, Birger;

    1983-01-01

    The BETA programming language is developed as part of the BETA project. The purpose of this project is to develop concepts, constructs and tools in the field of programming and programming languages. BETA has been developed from 1975 on and the various stages of the language are documented in [BETA...... a]. The application area of BETA is programming of embedded as well as distributed computing systems. For this reason a major goal has been to develop constructs that may be efficiently implemented. Furthermore the BETA language is intended to have a few number of basic but general constructs...... to SMALLTALK, BETA is a language in the ALGOL 60 ([ALGOL]) family. SIMULA 67 is a system description and a programming language. The DELTA language ([DELTA]) is a system description language only, allowing description of full concurrency, continuous change and component interaction, developed from a SIMULA...

  1. Beta emitters and radiation protection

    DEFF Research Database (Denmark)

    Jødal, Lars

    2009-01-01

    , and 90Y, using data from a freely available database. Bremsstrahlung yields were calculated for 90Y shielded by lead, aluminium, or perspex. Bremsstrahlung spectrum from 90Y shielded by perspex was measured, and attenuation of spectrum by lead was calculated. Whole-body and finger doses to persons...... the outside of the primary shielding material. If suitable shielding is used and larger numbers of handlings are divided among several persons, then handling of beta emitters can be a safe procedure....

  2. Review of double beta experiments

    OpenAIRE

    Sarazin, X.

    2012-01-01

    C13-10-22.1 International audience This paper gives a review of the double beta experimental techniques and projects, in the search for the Majorana neutrino. The purpose of this review is to detail, for each technique, the different origins of background, how they can be identified, and how they can be reduced. Advantages and limitations of the different techniques are discussed. 1. Introduction The neutrino is one of the most puzzling elementary particle with very unique properties. I...

  3. Electrolytic hydrogen in beta titanium

    International Nuclear Information System (INIS)

    Permeation of electrolytic hydrogen through beta titanium foils with palladium coated surfaces was studied using Ti--11.5 Mo--6 Zr--4.5 Sn. Ion bombardment etching followed by thin film vapor deposition of palladium were used to produce oxide-free titanium specimens for electrochemical hydrogen permeation and embrittlement studies. A thin metallic foil is cathodically charged with hydrogen on one side while the other side is maintained at a sufficiently anodic potential so that all the diffusing hydrogen is oxidized and turned into an equivalent current. The current is analyzed to determine diffusivity and solubility of hydrogen. X-ray diffraction was also used to determine the effects of hydrogen on the lattice parameter. Permeation experiments conducted with basic cyanide solutions exhibited simple diffusion behavior. The diffusivity at 210C for hydrogen through the beta alloy was 5.60 (+-1.92) x 10-7 cm2/s. Anomalous permeation occurred with hydrogen chemical potentials in acidic and basic solutions without cyanide during the later stages of the approach to steady state in the charging. This behavior is consistent with the trapping model of hydrogen in metals of McNabb and Foster. Plastic deformation and spontaneous cracking at the wetted portion of the specimen were observed under extreme conditions during this anomalous behavior. Part of the deformation is found to be reversible. In the mandrel bend experiments on the embrittlement phenomenon, the transgranular cleavage mode of fracture occurred. Interstitially dissolved hydrogen expanded the bcc lattice of the beta titanium with accompanying diffraction line broadening. The lattice contracted upon removal of the hydrogen. The satisfactory performance of the beta alloy Ti--11.5 Mo--6 Zr--4.5 Sn, in moderate electrochemical environments results principally from the protective oxide film

  4. Neutrinoless Double Beta Decay Experiments

    OpenAIRE

    Zuber, K.

    2014-01-01

    Neutrinoless double beta decay is the only process known so far able to test the neutrino intrinsic nature: its experimental observation would imply that the lepton number is violated by two units and prove that neutrinos have a Majorana mass components, being their own anti-particle. While several experiments searching for such a rare decay have been performed in the past, a new generation of experiments using different isotopes and techniques have recently released their results or are taki...

  5. Myokardinfarkt und Beta-Blocker

    Directory of Open Access Journals (Sweden)

    Stühlinger H-G

    2003-01-01

    Full Text Available Im Rahmen eines akuten koronaren Syndroms (akuter Herzinfarkt, Angina pectoris kommt es, aufgrund eines Ungleichgewichtes zwischen Angebot und Bedarf, zu einem akuten Mangel an Sauerstoff im Herzmuskel. Ursache ist eine reduzierte Sauerstoffzufuhr durch verengte bzw. verschlossene Gefäße. Bis zur Behebung der Ursache vergehen oft mehrere Stunden. In dieser Phase muß - durch Verminderung des Sauerstoffbedarfs im Herzmuskel - eine Verlangsamung der Nekroseentwicklung erreicht werden. Das Ausmaß der Nekrose wird reduziert, somit die für die Langzeitprognose wichtige Linksventrikelfunktion verbessert. Eine Verminderung des Sauerstoffbedarfs erreicht man durch kontrollierte Frequenzsenkung mittels intravenöser Beta-Blockade. In optimaler Weise wird diese Methode durch die Anwendung eines kardioselektiven Beta-Blockers mit kurzer Halbwertszeit durchgeführt. Beta-Blocker haben nicht nur auf die Nekroseentwicklung, sondern auch auf die Inzidenz von Rhythmusstörungen - besonders in der Akutphase - Auswirkungen. Vor allem die mit dieser therapeutischen Maßnahme verbundene Reduktion von Kammerflimmern ist von großer Bedeutung.

  6. Metalo-beta-lactamases Metallo-beta-lactamases

    Directory of Open Access Journals (Sweden)

    Rodrigo Elisandro Mendes

    2006-04-01

    Full Text Available Nos últimos anos tem sido observada maior incidência de bacilos Gram-negativos resistentes a cefalosporinas de espectro ampliado no ambiente hospitalar, ocasionando, assim, maior uso de betalactâmicos mais potentes, como os carbapenens. A utilização de carbapenens exerce maior pressão seletiva sobre a microbiota hospitalar, o que pode ocasionar aumento da resistência a esses agentes. Entre os mecanismos de resistência a carbapenens mais comumente identificados estão a produção de betalactamases, como, por exemplo, as pertencentes à classe D de Ambler e as que pertencem à classe B de Ambler, ou metalo-beta-lactamases (MbetaL. Essas últimas hidrolisam todos betalactâmicos comercialmente disponíveis, sendo a única exceção o monobactam aztreonam. Desde o início da década de 1990, novos genes que codificam MbetaLs têm sido descritos em microrganismos clinicamente importantes, como Pseudomonas spp., Acinetobacter spp. e membros da família Enterobacteriaceae. O encontro desses microrganismos não-sensíveis a carbapenens pode ser submetido a metodologias fenotípicas para detecção da produção de MbetaL com o intuito de auxiliar a Comissão de Controle de Infecção Hospitalar (CCIH e prevenir a disseminação desses determinantes de resistência, uma vez que genes que codificam MbetaLs estão contidos em estruturas genéticas que propiciam sua mobilidade de forma muito efetiva, sendo então facilmente disseminados.Increase isolation of Gram-negative bacilli resistant to broad-spectrum cephalosporin has been observed during the last few years, thus determining the use of more potent beta-lactams, such as carbapenems. The use of these antimicrobial agents may lead to the emergence of carbapenem resistant Gram-negative bacilli in the nosocomial environment. Carbapenem resistance may be due to the production of Ambler class D beta-lactamase or Ambler class B beta-lactamase, also called metallo-beta-lactamase (MbetaL. Apart from

  7. Beta-dosimetry studies at LLNL

    International Nuclear Information System (INIS)

    This paper summarizes three beta-dosimetry studies made recently at the Lawrence Livermore National Laboratory. The first study was to determine the beta-gamma exposure rates at the Los Alamos Godiva IV Critical Assembly. The beta spectra from the assembly were evaluated using absorption curves and the beta-gamma dose-rate ratios were determined at various distances from the assembly. A comparison was made of the doses determined using two types of TLD personnel dosimeters and a film badge. The readings of an Eberline RO-7 instrument and the dose rates determined by TLDs were compared. Shielding provided by various metals, gloves, and clothing were measured. The second study was to determine the beta energy response of the Eberline RO-7 instrument based on measurements made with the PTB beta sources. This study required additional calibration points for the PTB sources which were made using extrapolation chamber measurements. The third study resulted in two techniques to determine the beta energy (E/sub max/) from the readings of this-window portable survey instruments. Both techniques are based on the readings obtained using aluminium filters. One technique is for field application, requires one filter, and provides a quick estimate of the beta energy in three energy groups: 1.5 MeV. The second technique is more complex requiring measurements with two or three filters, but gives the beta energy and the approximate shape of the beta spectrum. 9 references, 6 figures

  8. On gaps in Rényi $\\beta$-expansions of unity for $\\beta > 1$ an algebraic number.

    OpenAIRE

    Verger-Gaugry, Jean-Louis

    2006-01-01

    Let $\\beta> 1$ be an algebraic number. We study the strings of zeros (“gaps”) in the Rényi $\\beta$ -expansion $d_{\\beta}(1)$ of unity which controls the set $\\mathbb{Z}_{\\beta}$ of $\\beta$-integers. Using a version of Liouville's inequality which extends Mahler's and Güting's approximation theorems, the strings of zeros in $d_{\\beta}(1)$ are shown to exhibit a “gappiness” asymptotically bounded above by $log(M(\\beta ))/ log(\\beta)$, where $M(\\beta)$ is the Mahler measure of $\\beta$ . The proo...

  9. Resistance training & beta-hydroxy-beta-methylbutyrate supplementation on hormones

    Directory of Open Access Journals (Sweden)

    Hamid Arazi

    2015-10-01

    Full Text Available RESUMOIntroduction:In recent years, there was an increased interest on the effects of beta-hydroxy-beta-methylbutyrate (HMB supplementation on skeletal muscle due to its anti-catabolic effects.Objectives:To investigate the effect of HMB supplementation on body composition, muscular strength and anabolic-catabolic hormones after resistance training.Methods:Twenty amateur male athletes were randomly assigned to supplement and control groups in a double-blind crossover design and participated in four weeks resistance training. Before and after the test period fasting blood samples were obtained to determine anabolic (the growth hormone and testosterone and catabolic (cortisol hormones, and fat mass, lean body mass (LBM and muscular strength were measured. Dependent and independent t-tests were used to analyze data.Results:After the training period, there were no significant differen-ces between the groups with respect to fat mass, LBM and anabolic-catabolic hormones. HMB supplementation resulted in a significantly greater strength gain (p≤0.05.Conclusion:Greater increase in strength for HMB group was not accompanied by body composition and basal circulating anabolic-catabolic hormonal changes. It seems that HMB supplementation may have beneficial effects on neurological adaptations of strength gain.

  10. GSK3beta is involved in JNK2-mediated beta-catenin inhibition.

    Directory of Open Access Journals (Sweden)

    Dong Hu

    Full Text Available BACKGROUND: We have recently reported that mitogen-activated protein kinase (MAPK JNK1 downregulates beta-catenin signaling and plays a critical role in regulating intestinal homeostasis and in suppressing tumor formation. This study was designed to determine whether JNK2, another MAPK, has similar and/or different functions in the regulation of beta-catenin signaling. METHODOLOGY AND PRINCIPAL FINDINGS: We used an in vitro system with manipulation of JNK2 and beta-catenin expression and found that activated JNK2 increased GSK3beta activity and inhibited beta-catenin expression and transcriptional activity. However, JNK2-mediated downregulation of beta-catenin was blocked by the proteasome inhibitor MG132 and GSK3beta inhibitor lithium chloride. Moreover, targeted mutations at GSK3beta phosphorylation sites (Ser33 and Ser37 of beta-catenin abrogated JNK2-mediated suppression of beta-catenin. In vivo studies further revealed that JNK2 deficiency led to upregulation of beta-catenin and increase of GSK3-beta phosphorylation in JNK2-/- mouse intestinal epithelial cells. Additionally, physical interaction and co-localization among JNK2, beta-catenin and GSK3beta were observed by immunoprecipitation, mammalian two-hybridization assay and confocal microscopy, respectively. CONCLUSION AND SIGNIFICANCE: In general, our data suggested that JNK2, like JNK1, interacts with and suppresses beta-catenin signaling in vitro and in vivo, in which GSK3beta plays a key role, although previous studies have shown distinct functions of JNK1 and JNK2. Our study also provides a novel insight into the crosstalk between Wnt/beta-catenin and MAPK JNKs signaling.

  11. Hyper-beta-alaninemia associated with beta-aminoaciduria and gamma-aminobutyricaciduaia, somnolence and seizures.

    Science.gov (United States)

    Scriver, C R; Pueschel, S; Davies, E

    1966-03-24

    Hyper-beta-alaninemia was found in a somnolent, convulsing infant. Hyper-beta-aminoaciduria (beta-ala, betaAIB and taurine) was also observed, varying directly with plasma beta-alanine concentration. The beta-aminoaciduria is explained by the interaction between beta-alanine and a specific cellular-transport system with preference for beta-amino compounds. Gamma-aminobutyricaciduria was also observed, its excretion being independent of beta-alanine levels. Dietary modifications, pyridoxine, pantothenic acid and antibiotic therapy were not beneficial. Post-mortem tissues had elevated levels of beta-alanine and carnosine; GABA levels in brain were probably elevated for the age of the patient. A proposed block in beta-alanine-alpha-ketoglutarate transaminase would expand the free beta-alanine pool, thus increasing tissue carnosine. beta-Alanine is a central-nervous-system depressant. Associated inhibition of GABA transaminase and displacement of GABA from central-nervous-system binding sites would produce GABAuria and convulsions. PMID:17926374

  12. Beta-2-mikroglobulin ved medicinske sygdomme

    DEFF Research Database (Denmark)

    Hansen, P B; Olsen, Niels Vidiendal

    1989-01-01

    Beta-2-microglobulin (beta 2M) is a low-molecular protein which is filtered freely over the glomeruli. Under normal circumstances, more than 99.9% is resorbed in the proximal tubuli of the kidneys and is metabolized there. In renal disease with damage to this segment of the nephron, eg acute tubulo......-interstitial nephropathy, increased quantities of beta 2M are excreted in the urine. If the rate of glomerular filtration is reduced, serum-beta 2M is increased and this is also the case in persons with increased cell division despite normal renal function. Serum-beta 2M is, therefore, raised in numerous malignant...... diseases and reflects the size of the tumour mass. During cytostatic treatment of myelomatosis and chronic lymphatic leukaemia, the serum-beta 2M levels decrease on remission and increase on relapse. In acute leukaemia and malignant lymphoma with infiltration of the CNS, similar conditions prevail for CSF...

  13. Experiments on double beta decay

    International Nuclear Information System (INIS)

    The Double Beta Decay, and especially (ββ)0ν mode, is an excellent test of Standard Model as well as of neutrino physics. From experimental point of view, a very large number of different techniques are or have been used increasing the sensitivity of this experiments quite a lot (the factor of 104 in the last 20 years). In future, in spite of several difficulties, the sensitivity would be increased further, keeping the interest of this very important process. (author) 4 figs., 5 tabs., 21 refs

  14. Beta blockers: A new role in chemotherapy

    OpenAIRE

    Nagaraja, Archana S; Sadaoui, Nouara C.; Lutgendorf, Susan K.; Ramondetta, Lois M.; Sood, Anil K

    2013-01-01

    Beta-blockers are a class of drugs widely used to treat cardiac, respiratory and other ailments. They act by blocking beta-adrenergic receptor–mediated signalling. Studies in various cancers have shown that patients taking a beta-blocker have higher survival and lower recurrence and metastasis rates. This is supported by several preclinical and in vitro studies showing that adrenergic activation modulates apoptosis, promotes angiogenesis and other cancer hallmarks, and these effects can be ab...

  15. The pancreatic beta cell surface proteome

    OpenAIRE

    Stützer, I.; Esterházy, D.; Stoffel, M.

    2012-01-01

    The pancreatic beta cell is responsible for maintaining normoglycaemia by secreting an appropriate amount of insulin according to blood glucose levels. The accurate sensing of the beta cell extracellular environment is therefore crucial to this endocrine function and is transmitted via its cell surface proteome. Various surface proteins that mediate or affect beta cell endocrine function have been identified, including growth factor and cytokine receptors, transporters, ion channels and prote...

  16. Constructions for a bivariate beta distribution

    OpenAIRE

    Olkin, Ingram; Trikalinos, Thomas A.

    2014-01-01

    The beta distribution is a basic distribution serving several purposes. It is used to model data, and also, as a more flexible version of the uniform distribution, it serves as a prior distribution for a binomial probability. The bivariate beta distribution plays a similar role for two probabilities that have a bivariate binomial distribution. We provide a new multivariate distribution with beta marginal distributions, positive probability over the unit square, and correlations over the full ...

  17. Theoretical aspects of double beta decay

    International Nuclear Information System (INIS)

    Considerable effort has been expended recently in theoretical studies of double beta decay. Much of this work has focussed on the constraints this process places on gauge theories of the weak interaction, in general, and on the neutrino mass matrix, in particular. In addition, interesting nuclear structure questions have arisen in studies of double beta decay matrix elements. After briefly reviewing the theory of double beta decay, some of the progress that has been made in these areas is summarized. 25 references

  18. First forbidden beta decay in light nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Millener, D.J.; Warburton, E.K.

    1984-01-01

    Beta decay matrix elements for the operators sigma dot del and sigma dot r are calculated for eight J/sup +/ ..-->.. J/sup -/ or J/sup -/ ..-->.. J/sup +/ beta transitions. Results using harmonic oscillator wave functions differ markedly from those using more realistic Woods-Saxon wave functions. A substantial contribution to the sigma dot del matrix elements from pion exchange currents is required to reproduce the experimental beta decay rates. 15 references.

  19. First forbidden beta decay in light nuclei

    International Nuclear Information System (INIS)

    Beta decay matrix elements for the operators sigma dot del and sigma dot r are calculated for eight J+ → J- or J- → J+ beta transitions. Results using harmonic oscillator wave functions differ markedly from those using more realistic Woods-Saxon wave functions. A substantial contribution to the sigma dot del matrix elements from pion exchange currents is required to reproduce the experimental beta decay rates. 15 references

  20. The Benchmark Beta, CAPM, and Pricing Anomalies.

    OpenAIRE

    Cheol S. Eun

    1994-01-01

    Recognizing that a part of the unobservable market portfolio is certainly observable, the author first reformulate the capital asset pricing model so that asset returns can be related to the 'benchmark' beta computed against a set of observable assets as well as the 'latent' beta computed against the remaining unobservable assets, and then shows that when the pricing effect of the latent beta is ignored, assets would appear to be systematically mispriced even if the capital asset pricing mode...

  1. C3 polymorphism in beta-thalassemia.

    Science.gov (United States)

    Germenis, A; Kalantzi, M; Karamerou, A; Politi, C; Fertakis, A

    1984-01-01

    The distribution of phenotypes and gene frequencies of the third component of complement (C3) were studied in 106 beta-thalassemic patients and in 112 carriers of the beta-thalassemia trait. A statistically significant association was found between the C3F gene and homozygous beta-thalassemia. It can be suggested that this association may be related with the high incidence of infections encountered in these patients. PMID:6419525

  2. Fabrication of beta particles detector for RMS

    International Nuclear Information System (INIS)

    The beta particles detector for RMS (radiation monitoring system) was fabricated to detect charged beta particles. The plastic scintillator was cutted, shaped, polished to make plastic disk for beta particles. The diameter of completed plastic scintillator disk is 40 mm and thickness is 1.5 mm. The mylar film and aluminium foil were used the front of plastic scintillator to intercept light and moisture. The completed plastic detector for RMS consist of the discriminator and counter were made by ULS (Co.). The absolute efficiency of plastic detector was 45.51% for beta particles (Sr/Y - 90)

  3. Sawtooth crashes at high beta on JET

    Energy Technology Data Exchange (ETDEWEB)

    Alper, B.; Huysmans, G.T.A.; Sips, A.C.C. [Commission of the European Communities, Abingdon (United Kingdom). JET Joint Undertaking; Nave, M.F.F. [Universidade Tecnica, Lisbon (Portugal). Inst. Superior Tecnico

    1994-07-01

    The sawtooth crashes on JET display features which depend on beta. The main observation is a transient bulging of flux surfaces (duration inferior to 30 microsec.), which is predominantly on the low field side and extends to larger radii as beta increases. This phenomenon reaches the plasma boundary when beta{sub N} exceeds 0.5 and in these cases is followed by an ELM within 50 microsec. These sawtooth/ELM events limit plasma performance. Modelling of mode coupling shows qualitative agreement between observations of the structure of the sawtooth precursor and the calculated internal kink mode at high beta. (authors). 6 refs., 5 figs.

  4. $\\beta$-decay study of $^{77}$Cu

    CERN Document Server

    Patronis, N; Górska, M; Huyse, M; Kruglov, K; Pauwels, D; Van de Vel, K; Van Duppen, P; Van Roosbroeck, J; Thomas, J-C; Franchoo, S; Cederkäll, J; Fedosseev, V; Fynbo, H; Georg, U; Jonsson, O; Köster, U; Materna, T; Mathieu, L; Serot, O; Weissman, L; Müller, W F; Mishin, V I; Fedorov, D

    2009-01-01

    A beta-decay study of Cu-77 has been performed at the ISOLDE mass separator with the aim to deduce its beta-decay properties and to obtain spectroscopic information on Zn-77. Neutron-rich copper isotopes were produced by means of proton- or neutron-induced fission reactions on U-238. After the production, Cu-77 was selectively laser ionized, mass separated and sent to different detection systems where beta-gamma and beta-n coincidence data were collected. We report on the deduced half-live, decay scheme, and possible spin assignment of 77Cu.

  5. Milk Intolerance, Beta-Casein and Lactose

    Directory of Open Access Journals (Sweden)

    Sebely Pal

    2015-08-01

    Full Text Available True lactose intolerance (symptoms stemming from lactose malabsorption is less common than is widely perceived, and should be viewed as just one potential cause of cows’ milk intolerance. There is increasing evidence that A1 beta-casein, a protein produced by a major proportion of European-origin cattle but not purebred Asian or African cattle, is also associated with cows’ milk intolerance. In humans, digestion of bovine A1 beta-casein, but not the alternative A2 beta-casein, releases beta-casomorphin-7, which activates μ-opioid receptors expressed throughout the gastrointestinal tract and body. Studies in rodents show that milk containing A1 beta-casein significantly increases gastrointestinal transit time, production of dipeptidyl peptidase-4 and the inflammatory marker myeloperoxidase compared with milk containing A2 beta-casein. Co-administration of the opioid receptor antagonist naloxone blocks the myeloperoxidase and gastrointestinal motility effects, indicating opioid signaling pathway involvement. In humans, a double-blind, randomized cross-over study showed that participants consuming A1 beta-casein type cows’ milk experienced statistically significantly higher Bristol stool values compared with those receiving A2 beta-casein milk. Additionally, a statistically significant positive association between abdominal pain and stool consistency was observed when participants consumed the A1 but not the A2 diet. Further studies of the role of A1 beta-casein in milk intolerance are needed.

  6. Milk Intolerance, Beta-Casein and Lactose

    OpenAIRE

    Sebely Pal; Keith Woodford; Sonja Kukuljan; Suleen Ho

    2015-01-01

    True lactose intolerance (symptoms stemming from lactose malabsorption) is less common than is widely perceived, and should be viewed as just one potential cause of cows’ milk intolerance. There is increasing evidence that A1 beta-casein, a protein produced by a major proportion of European-origin cattle but not purebred Asian or African cattle, is also associated with cows’ milk intolerance. In humans, digestion of bovine A1 beta-casein, but not the alternative A2 beta-casein, releases beta-...

  7. Milk Intolerance, Beta-Casein and Lactose.

    Science.gov (United States)

    Pal, Sebely; Woodford, Keith; Kukuljan, Sonja; Ho, Suleen

    2015-09-01

    True lactose intolerance (symptoms stemming from lactose malabsorption) is less common than is widely perceived, and should be viewed as just one potential cause of cows' milk intolerance. There is increasing evidence that A1 beta-casein, a protein produced by a major proportion of European-origin cattle but not purebred Asian or African cattle, is also associated with cows' milk intolerance. In humans, digestion of bovine A1 beta-casein, but not the alternative A2 beta-casein, releases beta-casomorphin-7, which activates μ-opioid receptors expressed throughout the gastrointestinal tract and body. Studies in rodents show that milk containing A1 beta-casein significantly increases gastrointestinal transit time, production of dipeptidyl peptidase-4 and the inflammatory marker myeloperoxidase compared with milk containing A2 beta-casein. Co-administration of the opioid receptor antagonist naloxone blocks the myeloperoxidase and gastrointestinal motility effects, indicating opioid signaling pathway involvement. In humans, a double-blind, randomized cross-over study showed that participants consuming A1 beta-casein type cows' milk experienced statistically significantly higher Bristol stool values compared with those receiving A2 beta-casein milk. Additionally, a statistically significant positive association between abdominal pain and stool consistency was observed when participants consumed the A1 but not the A2 diet. Further studies of the role of A1 beta-casein in milk intolerance are needed. PMID:26404362

  8. Beta attenuation transmission system (BATS)

    International Nuclear Information System (INIS)

    The beta attenuation transmission system (BATS) is an automated radiation gauge designed for quantitative measurement of component thickness in explosive detonators. The BATS was designed and built by Group M-1, the Nondestructive Testing Group, of the Los Alamos Scientific Laboratory to measure the areal thickness, in mg/cm2, of a cylinder of high explosive (HE) enclosed within a plastic holder. The problem is to determine the density of the HE. A 90Sr source is collimated by a 0.25 x 1.59-mm slit, and the transmitted beta-particle flux is detected by a plastic scintillator, coupled to a photomultiplier tube. The detonator is transported through the radiation beam by a leadscrew, ballnut, stepping-motor combination. Continuous analog position data are available, derived from the output from a linear-actuated potentiometer attached to the scanner. A linear electrometer amplifies the detected signal, which is then integrated for a preselected time, to obtain the desired statistical accuracy. A microprocessor (μP) is used to control the scanner position and to make the data readings at the assigned positions. The data are stored, and, at the completion of the scan, are processed into the desired format. The final answer is displayed to the operator or output to a peripheral device for permanent record. The characteristics of the radiation source, the collimator, the signal detection and conditioning, and the final results are described in detail. The scanner and the microprocessor control system are briefly outlined

  9. Beta attenuation transmission system (BATS)

    Energy Technology Data Exchange (ETDEWEB)

    Hagan, R.C.; Fullbright, H.J.

    1977-01-01

    The beta attenuation transmission system (BATS) is an automated radiation gauge designed for quantitative measurement of component thickness in explosive detonators. The BATS was designed and built by Group M-1, the Nondestructive Testing Group, of the Los Alamos Scientific Laboratory to measure the areal thickness, in mg/cm/sup 2/, of a cylinder of high explosive (HE) enclosed within a plastic holder. The problem is to determine the density of the HE. A /sup 90/Sr source is collimated by a 0.25 x 1.59-mm slit, and the transmitted beta-particle flux is detected by a plastic scintillator, coupled to a photomultiplier tube. The detonator is transported through the radiation beam by a leadscrew, ballnut, stepping-motor combination. Continuous analog position data are available, derived from the output from a linear-actuated potentiometer attached to the scanner. A linear electrometer amplifies the detected signal, which is then integrated for a preselected time, to obtain the desired statistical accuracy. A microprocessor (..mu..P) is used to control the scanner position and to make the data readings at the assigned positions. The data are stored, and, at the completion of the scan, are processed into the desired format. The final answer is displayed to the operator or output to a peripheral device for permanent record. The characteristics of the radiation source, the collimator, the signal detection and conditioning, and the final results are described in detail. The scanner and the microprocessor control system are briefly outlined.

  10. Pion beta decay at PILAC

    International Nuclear Information System (INIS)

    The proposal to build PILAC presents the possibility of making an improved measurement of the pion beta decay rate. The rate for the decay π+ → π0e+νe is predicted by the Standard Model (SM) to be R(π+ → π0e+νe) = 0.3999 ± 0.0005 s-1. The best experimental number, from LAMPF Experiment 32, using in-flight decays, is R(π+ → π0e+νe) = 0.394 ± 0.0015 s-1. A precise measurement would test the SM by testing the unitarity of the Cabibbo- Kobayashi-Maskawa matrix, for which one analysis of the nuclear beta decay data has shown a 0.4% discrepancy. Thus an experiment at the 0. 2% level would be a significant one. Detailed study of possible designs will be needed, as well as extensive testing of components. The reduction of systematic errors to the 0.1% level can only be done over a period of years with a highly stable apparatus and beam. At a minimum, three years of occupancy of a beam line, with 800 hours per year, would be required. 23 refs., 2 figs., 2 tabs

  11. Challenges in Double Beta Decay

    Directory of Open Access Journals (Sweden)

    Oliviero Cremonesi

    2014-01-01

    Full Text Available In the past ten years, neutrino oscillation experiments have provided the incontrovertible evidence that neutrinos mix and have finite masses. These results represent the strongest demonstration that the electroweak Standard Model is incomplete and that new Physics beyond it must exist. In this scenario, a unique role is played by the Neutrinoless Double Beta Decay searches which can probe lepton number conservation and investigate the Dirac/Majorana nature of the neutrinos and their absolute mass scale (hierarchy problem with unprecedented sensitivity. Today Neutrinoless Double Beta Decay faces a new era where large-scale experiments with a sensitivity approaching the so-called degenerate-hierarchy region are nearly ready to start and where the challenge for the next future is the construction of detectors characterized by a tonne-scale size and an incredibly low background. A number of new proposed projects took up this challenge. These are based either on large expansions of the present experiments or on new ideas to improve the technical performance and/or reduce the background contributions. In this paper, a review of the most relevant ongoing experiments is given. The most relevant parameters contributing to the experimental sensitivity are discussed and a critical comparison of the future projects is proposed.

  12. Association of heterocellular HPFH, beta(+)-thalassaemia, and delta beta(0)-thalassaemia: haematological and molecular aspects.

    OpenAIRE

    Cianetti, L; Care, A; Sposi, N M; Giampaolo, A; Calandrini, M; Petrini, M.; Massa, A.; Marinucci, M.; Mavilio, F; Ceccanti, M.

    1984-01-01

    An Italian family in which heterocellular hereditary persistence of fetal haemoglobin (HPFH) interacts with both beta(+)- and delta beta-thalassaemia is described. The index case was an 8 year old girl who was presumed to inherit both heterocellular HPFH and beta (+)-thalassaemia from her mother and delta beta-thalassaemia from her father. She was healthy and never needed blood transfusions. The possible contribution of heterocellular HPFH to the less severe expression of the compound delta b...

  13. Clusters of conserved beta cell marker genes for assessment of beta cell phenotype.

    Directory of Open Access Journals (Sweden)

    Geert A Martens

    Full Text Available BACKGROUND AND METHODOLOGY: The aim of this study was to establish a gene expression blueprint of pancreatic beta cells conserved from rodents to humans and to evaluate its applicability to assess shifts in the beta cell differentiated state. Genome-wide mRNA expression profiles of isolated beta cells were compared to those of a large panel of other tissue and cell types, and transcripts with beta cell-abundant and -selective expression were identified. Iteration of this analysis in mouse, rat and human tissues generated a panel of conserved beta cell biomarkers. This panel was then used to compare isolated versus laser capture microdissected beta cells, monitor adaptations of the beta cell phenotype to fasting, and retrieve possible conserved transcriptional regulators. PRINCIPAL FINDINGS: A panel of 332 conserved beta cell biomarker genes was found to discriminate both isolated and laser capture microdissected beta cells from all other examined cell types. Of all conserved beta cell-markers, 15% were strongly beta cell-selective and functionally associated to hormone processing, 15% were shared with neuronal cells and associated to regulated synaptic vesicle transport and 30% with immune plus gut mucosal tissues reflecting active protein synthesis. Fasting specifically down-regulated the latter cluster, but preserved the neuronal and strongly beta cell-selective traits, indicating preserved differentiated state. Analysis of consensus binding site enrichment indicated major roles of CREB/ATF and various nutrient- or redox-regulated transcription factors in maintenance of differentiated beta cell phenotype. CONCLUSIONS: Conserved beta cell marker genes contain major gene clusters defined by their beta cell selectivity or by their additional abundance in either neural cells or in immune plus gut mucosal cells. This panel can be used as a template to identify changes in the differentiated state of beta cells.

  14. An imidazoline compound completely counteracts interleukin-1[beta] toxic effects to rat pancreatic islet [beta] cells

    DEFF Research Database (Denmark)

    Papaccio, Gianpaolo; Nicoletti, Ferdinando; Pisanti, Francesco A; Galdieri, Michela; Bendtzen, Klaus

    2002-01-01

    In vitro studies have demonstrated that interleukin (IL)-1beta decreases insulin and DNA contents in pancreatic islet beta cells, causing structural damage, that it is toxic to cultured human islet beta cells and that it is able to induce apoptosis in these cells....

  15. Expressions of GSK-3beta, Beta-Catenin and PPAR-Gamma in Medulloblastoma

    Institute of Scientific and Technical Information of China (English)

    Xiong Zhang; Lu Si; Yu Li; Can Mi

    2009-01-01

    Objective: To investigate the expressions of GSK-3beta, Beta-catenin and PPAR-gamma, and their relationship in medulloblastoma, and to explore their value in clinic application.Methods: Immunohistochemical staining with SP method was conducted to determine the expressions of GSK-3beta, Beta-catenin and PPAR-gamma in 48 cases of medulloblastoma and 10 normal cerebellar tissues.Results: The rate of abnormal expressions of beta-catenin and PPAR-gamma in MB was higher than that in normal. Conversely, GSK-3beta in MB was lower than that in the normal (P<0.05). Furthermore, in medulloblastoma, beta-catenin and GSK-3beta showed a negative correlation, PPAR-gamma and beta-catenin had a positive correlation.Conclusion: Abnormal expression of beta-catenin plays a crucial role in the development of medulloblastoma. Meanwhile, PPAR-gamma and GSK-3beta which are tightly related with beta-catenin are both involved in the genesis and development of medulloblastoma.

  16. Imperfect World of beta beta-decay Nuclear Data Sets

    Energy Technology Data Exchange (ETDEWEB)

    Pritychenko, B. [Brookhaven National Lab. (BNL), Upton, NY (United States). NNDC

    2015-01-03

    The precision of double-beta ββ-decay experimental half lives and their uncertainties is reanalyzed. The method of Benford's distributions has been applied to nuclear reaction, structure and decay data sets. First-digit distribution trend for ββ-decay T2v1/2 is consistent with large nuclear reaction and structure data sets and provides validation of experimental half-lives. A complementary analysis of the decay uncertainties indicates deficiencies due to small size of statistical samples, and incomplete collection of experimental information. Further experimental and theoretical efforts would lead toward more precise values of-decay half-lives and nuclear matrix elements.

  17. Dosimetry of low-energy beta radiation

    Energy Technology Data Exchange (ETDEWEB)

    Borg, J.

    1996-08-01

    Useful techniques and procedures for determination of absorbed doses from exposure in a low-energy {beta} radiation field were studied and evaluated in this project. The four different techniques included were {beta} spectrometry, extrapolation chamber dosimetry, Monte Carlo (MC) calculations, and exoelectron dosimetry. As a typical low-energy {beta} radiation field a moderated spectrum from a {sup 14}C source (E{sub {beta}},{sub max} =156 keV) was chosen for the study. The measured response of a Si(Li) detector to photons (bremsstrahlung) showed fine agreement with the MC calculated photon response, whereas the difference between measured and MC calculated responses to electrons indicates an additional dead layer thickness of about 12 {mu}m in the Si(Li) detector. The depth-dose profiles measured with extrapolation chambers at two laboratories agreed very well, and it was confirmed that the fitting procedure previously reported for {sup 147}Pm depth-dose profiles is also suitable for {beta} radiation from {sup 14}C. An increasing difference between measured and MC calculated dose rates for increasing absorber thickness was found, which is explained by limitations of the EGS4 code for transport of very low-energy electrons (below 10-20 keV). Finally a study of the thermally stimulated exoelectron emission (TSEE) response of BeO thin film dosemeters to {beta} radiation for radiation fields with maximum {beta} energies ranging from 67 keV to 2.27 MeV is reported. For maximum {beta} energies below approximately 500 keV, a decrease in the response amounting to about 20% was observed. It is thus concluded that a {beta} dose higher than about 10 {mu}Gy can be measured with these dosemeters to within 0 to -20% independently of the {beta}energy for E{sub {beta}},{sub max} values down to 67 keV. (au) 12 tabs., 38 ills., 71 refs.

  18. [Hemoglobin C -- beta-thalassemia disease and homozygous beta-thalassemia in a black African family (author's transl)].

    Science.gov (United States)

    Basset, P; Fall, M; Oudart, J L

    1975-01-01

    The study of a Malian family has allowed to prove existence of two types of beta-thalassemia genes: the beta0 gene which suppresses the synthesis of the beta chain into cis position and the beta+ gene which slows down only partially this synthesis. The difference between this two genes has been possible owing to the hemoglobin C found in this family and induced by the betaC mutated gene. The segregation of the four genes betaA, betaC, beta0 thal, and beta+ thal. has allowed to compare all the possible phenotypes deriving from the combinations by two of these allelic genes. PMID:128735

  19. Search for beta sup - and beta sup -beta sup - decays of sup 4 sup 8 Ca

    CERN Document Server

    Bakalyarov, A; Barabash, A; Briançon, C; Brudanin, V; Egorov, V; Hubert, F; Hubert, P; Kovalik, A; Lebedev, V I; Rukhadze, N I; Stekl, I; Umatov, V; Vylov, T D

    2002-01-01

    A sup 4 sup 8 CaCO sub 3 powder sample containing 20.18 g of sup 4 sup 8 Ca was measured for 797 h with a 400 cm sup 3 low-background HPGe detector. New limits on decays of sup 4 sup 8 Ca were obtained. For single beta transitions to sup 4 sup 8 Sc the limits are equal to 0.71x10 sup 2 sup 0 y, 1.1x10 sup 2 sup 0 y, and 0.82x10 sup 2 sup 0 y for transitions to the ground state, excited 5 sup + and 4 sup + states, respectively. The new limits on double beta decay to excited states of sup 4 sup 8 Ti are equal to 0.47x10 sup 2 sup 0 y, 1.1x10 sup 2 sup 0 y, and 0.90x10 sup 2 sup 0 y for transitions to the first 2 sup + , second 2 sup + and first 0 sup + excited states, respectively. All limits are given at the 90% CL.

  20. Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4

    DEFF Research Database (Denmark)

    Richter, Wito; Day, Peter; Agrawal, Rani; Bruss, Matthew D; Granier, Sébastien; Wang, Yvonne L; Rasmussen, Søren Gøgsig Faarup; Horner, Kathleen; Wang, Ping; Lei, Tao; Patterson, Andrew J; Kobilka, Brian; Conti, Marco

    2008-01-01

    Beta1- and beta2-adrenergic receptors (betaARs) are highly homologous, yet they play clearly distinct roles in cardiac physiology and pathology. Myocyte contraction, for instance, is readily stimulated by beta1AR but not beta2AR signaling, and chronic stimulation of the two receptors has opposing...

  1. Beta cell proliferation and growth factors

    DEFF Research Database (Denmark)

    Nielsen, Jens Høiriis; Svensson, C; Møldrup, Annette;

    1999-01-01

    Formation of new beta cells can take place by two pathways: replication of already differentiated beta cells or neogenesis from putative islet stem cells. Under physiological conditions both processes are most pronounced during the fetal and neonatal development of the pancreas. In adulthood litt...

  2. Beta-agonists and animal welfare

    Science.gov (United States)

    The use of beta-agonists in animal feed is a high profile topic within the U.S. as consumers and activist groups continue to question its safety. The only beta-agonist currently available for use in swine is ractopamine hydrochloride (RAC). This is available as Paylean™ (Elanco Animal Health – FDA a...

  3. Dosimetry of Low-Energy Beta Radiation

    DEFF Research Database (Denmark)

    Borg, Jette

    Useful techniques and procedures for derermination of absorbed doses from exposure in a low-energy beta radiation were studied and evaluated. The four techniques included were beta spectrometry, extrapolation chamber dosimetry, Monte Carlo (MC) calculations, and exoelectron dosimetry. As a typical...

  4. Beta spectra. II-Positron spectra

    International Nuclear Information System (INIS)

    Using the Fermi theory of beta decay, the beta spectra for 30 positron emitters have been computed, introducing a correction factor for unique forbidden transitions. The spectra are ploted vs. energy, once normalised, and tabulated with the related Fermi functions. The average and median energies are calculated. (author)

  5. A proportional-scintillation counter beta spectrometer

    International Nuclear Information System (INIS)

    Using a proportional counter for coincidence gating of events in a plastic scintillator provides selective registration of beta interactions in the scintillator. This technique has been used to construct a field instrument that can selectively collect beta spectra (coincidence gating) or gamma spectra (anticoincidence gating). Associated dose rates are calculated from the spectra

  6. Broad resonances and beta-decay

    DEFF Research Database (Denmark)

    Riisager, K.; Fynbo, H. O. U.; Hyldegaard, S.;

    2015-01-01

    Beta-decay into broad resonances gives a distorted lineshape in the observed energy spectrum. Part of the distortion arises from the phase space factor, but we show that the beta-decay matrix element may also contribute. Based on a schematic model for p-wave continuum neutron states it is argued...

  7. Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy

    OpenAIRE

    Butler, A. E.; Cao-Minh, L.; Galasso, R; Rizza, R. A.; Corradin, A.; Cobelli, C; Butler, P C

    2010-01-01

    Aims/hypothesis We sought to establish the extent and basis for adaptive changes in beta cell numbers in human pregnancy. Methods Pancreas was obtained at autopsy from women who had died while pregnant (n = 18), post-partum (n = 6) or were not pregnant at or shortly before death (controls; n = 20). Pancreases were evaluated for fractional pancreatic beta cell area, islet size and islet fraction of beta cells, beta cell replication (Ki67) and apoptosis (TUNEL), and indirect markers of beta cel...

  8. Antibodies against chromosomal beta-lactamase

    DEFF Research Database (Denmark)

    Giwercman, B; Rasmussen, J W; Ciofu, Oana; Clemmentsen, I; Schumacher, H; Høiby, N

    1994-01-01

    A murine monoclonal anti-chromosomal beta-lactamase antibody was developed and an immunoblotting technique was used to study the presence of serum and sputum antibodies against Pseudomonas aeruginosa chromosomal group 1 beta-lactamase in patients with cystic fibrosis (CF). The serum antibody...... response was studied with serum samples collected in 1992 from 56 CF patients in a cross-sectional study and with serum samples from 18 CF patients in a longitudinal study. Anti-beta-lactamase immunoglobulin G antibodies were present in all of the serum samples from the patients with chronic...... bronchopulmonary P. aeruginosa infection (CF + P) but in none of the CF patients with no or intermittent P. aeruginosa infection. Anti-beta-lactamase antibodies were present in serum from CF + P patients after six antipseudomonal courses (median) and correlated with infection with a beta-lactam-resistant strain of...

  9. The search for neutrinoless double beta decay

    CERN Document Server

    Gomez-Cadenas, J J; Mezzetto, M; Monrabal, F; Sorel, M

    2011-01-01

    In the last few years the search for neutrinoless double beta decay has evolved from being almost a marginal activity in neutrino physics to one of the highest priorities for understanding neutrinos and the origin of mass. There are two main reasons for this paradigm shift: the discovery of neutrino oscillations, which clearly established the existence of massive neutrinos; and the existence of an unconfirmed, but not refuted, claim of evidence for neutrinoless double decay in 76Ge. As a consequence, a new generation of experiments, employing different detection techniques and {\\beta}{\\beta} isotopes, is being actively promoted by experimental groups across the world. In addition, nuclear theorists are making remarkable progress in the calculation of the neutrinoless double beta decay nuclear matrix elements, thus eliminating a substantial part of the theoretical uncertainties affecting the particle physics interpretation of this process. In this report, we review the main aspects of the double beta decay pro...

  10. Simultaneous beta/gamma digital spectroscopy

    Science.gov (United States)

    Farsoni, Abdollah T.

    A state-of-the-art radiation detection system for simultaneous spectroscopy of beta-particles and gamma-rays has been developed. The system utilizes a triple-layer phoswich detector and a customized Digital Pulse Processor (DPP) built in our laboratory. The DPP board was designed to digitally capture the analog signal pulses and, following several digital preprocessing steps, transfer valid pulses to the host computer for further digital processing. A MATLAB algorithm was developed to digitally discriminate beta and gamma events and reconstruct separate beta and gamma-ray energy spectra with minimum crosstalk. The spectrometer proved to be an effective tool for recording separate beta and gamma-ray spectra from mixed radiation fields. The system as a beta-gamma spectrometer will have broad-ranging applications in nuclear non-proliferation, radioactive waste management, worker safety, systems reliability, dose assessment, and risk analysis.

  11. Genetics Home Reference: dopamine beta-hydroxylase deficiency

    Science.gov (United States)

    ... Genetics Home Health Conditions dopamine beta-hydroxylase deficiency dopamine beta-hydroxylase deficiency Enable Javascript to view the ... boxes. Print All Open All Close All Description Dopamine beta (β)-hydroxylase deficiency is a condition that ...

  12. Clusters of conserved beta cell marker genes for assessment of beta cell phenotype

    DEFF Research Database (Denmark)

    Martens, Geert A; Jiang, Lei; Hellemans, Karine H;

    2011-01-01

    of a large panel of other tissue and cell types, and transcripts with beta cell-abundant and -selective expression were identified. Iteration of this analysis in mouse, rat and human tissues generated a panel of conserved beta cell biomarkers. This panel was then used to compare isolated versus laser......The aim of this study was to establish a gene expression blueprint of pancreatic beta cells conserved from rodents to humans and to evaluate its applicability to assess shifts in the beta cell differentiated state. Genome-wide mRNA expression profiles of isolated beta cells were compared to those...... capture microdissected beta cells, monitor adaptations of the beta cell phenotype to fasting, and retrieve possible conserved transcriptional regulators....

  13. Conformation, molecular packing and field effect mobility of regioregular beta,beta'-dihexylsexithiophiophene

    DEFF Research Database (Denmark)

    Kiriy, N.; Kiriy, A.; Bocharova, V.;

    2004-01-01

    (SEM), atomic force microscopy (AFM), and X-ray techniques. Absorption spectra of a beta,beta'-DH6T spin-cast film indicate the planar conformation of the aromatic backbone. SEM and AFM reveal the formation of an ordered lamellar phase. As a single-crystal X-ray study shows, beta,beta'-DH6T exhibits......Improved synthesis, charge carrier mobility, conformation, crystalline structure, and molecular packing of the regiochemically pure 4',3""-dihexyl-2,2';5',2";5",2 "';5"',2"";5"",2""'-sexithiophene (beta,beta'-DH6T) are reported. The sum of charge carrier mobilities of beta,beta'-DH6T measured...... by the pulse-radiolysis time-resolved microwave conductivity (PR-TRMC) technique was found to be Sigmamu(min) = 3.9 x 10(-3) cm(2) V-1 s(-1), which is comparable with the PR-TRMC mobility found for alpha,omega-DH6T. The field-effect mobility (FEM) of beta,beta'-DH6T was found to be on the order of 10(-5) cm(2...

  14. Ellagic acid promotes A{beta}42 fibrillization and inhibits A{beta}42-induced neurotoxicity

    Energy Technology Data Exchange (ETDEWEB)

    Feng, Ying [Department of Histology and Embryology, College of Basic Medical Science, China Medical University, Shenyang 110001 (China); Tsinghua University School of Medicine, Haidian District, Beijing 100084 (China); Yang, Shi-gao; Du, Xue-ting; Zhang, Xi; Sun, Xiao-xia; Zhao, Min [Tsinghua University School of Medicine, Haidian District, Beijing 100084 (China); Sun, Gui-yuan, E-mail: sungy2004@sohu.com [Department of Histology and Embryology, College of Basic Medical Science, China Medical University, Shenyang 110001 (China); Liu, Rui-tian, E-mail: rtliu@tsinghua.edu.cn [Tsinghua University School of Medicine, Haidian District, Beijing 100084 (China)

    2009-12-25

    Smaller, soluble oligomers of {beta}-amyloid (A{beta}) play a critical role in the pathogenesis of Alzheimer's disease (AD). Selective inhibition of A{beta} oligomer formation provides an optimum target for AD therapy. Some polyphenols have potent anti-amyloidogenic activities and protect against A{beta} neurotoxicity. Here, we tested the effects of ellagic acid (EA), a polyphenolic compound, on A{beta}42 aggregation and neurotoxicity in vitro. EA promoted A{beta} fibril formation and significant oligomer loss, contrary to previous results that polyphenols inhibited A{beta} aggregation. The results of transmission electron microscopy (TEM) and Western blot displayed more fibrils in A{beta}42 samples co-incubated with EA in earlier phases of aggregation. Consistent with the hypothesis that plaque formation may represent a protective mechanism in which the body sequesters toxic A{beta} aggregates to render them harmless, our MTT results showed that EA could significantly reduce A{beta}42-induced neurotoxicity toward SH-SY5Y cells. Taken together, our results suggest that EA, an active ingredient in many fruits and nuts, may have therapeutic potential in AD.

  15. Total synthesis of human beta-lipotropin.

    OpenAIRE

    Blake, J; Li, C. H.

    1983-01-01

    The total synthesis of human beta-lipotropin has been accomplished by the new segment-coupling method in aqueous solution. The peptides Ac-Arg-beta-lipotropin-(61-89) (I) and [GlyS60]-beta-lipotropin-(1-60) (II) were synthesized by the solid-phase method. Reaction of peptide I with citraconic anhydride followed by brief digestion with trypsin to remove the acetylarginyl group, gave Ia. Reaction of peptide II with citraconic anhydride gave the citraconyl peptide IIa. Ia and IIa were coupled to...

  16. Rotational beta expansion: Ergodicity and Soficness

    OpenAIRE

    Akiyama, Shigeki; Caalim, Jonathan

    2015-01-01

    We study a family of piecewise expanding maps on the plane, generated by composition of a rotation and an expansive similitude of expansion constant $\\beta$. We give two constants $B_1$ and $B_2$ depending only on the fundamental domain that if $\\beta>B_1$ then the expanding map has a unique absolutely continuous invariant probability measure, and if $\\beta>B_2$ then it is equivalent to $2$-dimensional Lebesgue measure. Restricting to a rotation generated by $q$-th root of unity $\\zeta$ with ...

  17. Falsifying Baryogenesis with Neutrinoless Double Beta Decay

    CERN Document Server

    Graf, Lukas

    2016-01-01

    We discuss the relation between lepton number violation at high and low energies, particularly, the constraints on baryogenesis models, which would be implied by an observation of neutrinoless double beta decay. The primordial baryon asymmetry can be washed out by effective lepton number violating operators triggering neutrinoless double beta decay in combination with sphaleron processes. A generic conclusion is that popular models of baryogenesis are excluded if a non-standard mechanism of neutrinoless double beta decay, i.e., other than the standard light neutrino exchange, is observed. Apart from the effective field approach, we also outline the possible extension of our arguments to a general UV-completed model.

  18. Beta-alanine synthesis in Escherichia coli.

    OpenAIRE

    Cronan, J. E.

    1980-01-01

    The enzyme, aspartate 1-decarboxylase (L-aspartate 1-carboxy-lyase; EC 4.1.1.15), that catalyzes the reaction aspartate leads to beta-alanine + CO2 was found in extracts of Escherichia coli. panD mutants of E. coli are defective in beta-alanine biosynthesis and lack aspartate 1-decarboxylase. Therefore, the enzyme functions in the biosynthesis of the beta-alanine moiety of pantothenate. The genetic lesion in these mutants is closely linked to the other pantothenate (pan) loci of E. coli K-12.

  19. Review of modern double beta decay experiments

    Science.gov (United States)

    Barabash, A. S.

    2015-10-01

    The review of modern experiments on search and studying of double beta decay processes is done. Results of the most sensitive current experiments are discussed. The main attention is paid to EXO-200, KamLAND-Zen, GERDA-I and CUORE-0 experiments. Modern values of T1/2(2ν) and best present limits on neutrinoless double beta decay and double beta decay with Majoron emission are presented. Conservative limits on effective mass of a Majorana neutrino ( at the level of ˜ 0.01-0.1 eV are discussed.

  20. Beta cell count instead of beta cell mass to assess and localize growth in beta cell population following pancreatic duct ligation in mice.

    Directory of Open Access Journals (Sweden)

    Marie Chintinne

    Full Text Available BACKGROUND: Pancreatic-tail duct ligation (PDL in adult rodents has been reported to induce beta cell generation and increase beta cell mass but increases in beta cell number have not been demonstrated. This study examines whether PDL increases beta cell number and whether this is caused by neogenesis of small clusters and/or their growth to larger aggregates. METHODOLOGY: Total beta cell number and its distribution over small (100 µm clusters was determined in pancreatic tails of 10-week-old mice, 2 weeks after PDL or sham. PRINCIPAL FINDINGS: PDL increased total beta cell mass but not total beta cell number. It induced neogenesis of small beta cell clusters (2.2-fold higher number which contained a higher percent proliferating beta cells (1.9% Ki67+cells than sham tails (<0.2%; their higher beta cell number represented <5% of total beta cell number and was associated with a similar increase in alpha cell number. It is unknown whether the regenerative process is causally related to the inflammatory infiltration in PDL-tails. Human pancreases with inflammatory infiltration also exhibited activation of proliferation in small beta cell clusters. CONCLUSIONS/SIGNIFICANCE: The PDL model illustrates the advantage of direct beta cell counts over beta cell mass measurements when assessing and localizing beta cell regeneration in the pancreas. It demonstrates the ability of the adult mouse pancreas for neogenesis of small beta cell clusters with activated beta cell proliferation. Further studies should investigate conditions under which neoformed small beta cell clusters grow to larger aggregates and hence to higher total beta cell numbers.

  1. Energetic, Structural, and Antimicrobial Analyses of [beta]-Lactam Side Chain Recognition by [beta]-Lactamases

    Energy Technology Data Exchange (ETDEWEB)

    Caselli, E.; Powers, R.A.; Blaszczak, L.C.; Wu, C.Y.E.; Prati, F.; Shoichet, B.K. (NWU)

    2010-03-05

    Penicillins and cephalosporins are among the most widely used and successful antibiotics. The emergence of resistance to these {beta}-lactams, most often through bacterial expression of {beta}-lactamases, threatens public health. To understand how {beta}-lactamases recognize their substrates, it would be helpful to know their binding energies. Unfortunately, these have been difficult to measure because {beta}-lactams form covalent adducts with {beta}-lactamases. This has complicated functional analyses and inhibitor design. To investigate the contribution to interaction energy of the key amide (R1) side chain of {beta}-lactam antibiotics, eight acylglycineboronic acids that bear the side chains of characteristic penicillins and cephalosporins, as well as four other analogs, were synthesized. These transition-state analogs form reversible adducts with serine {beta}-lactamases. Therefore, binding energies can be calculated directly from K{sub i} values. The K{sub i} values measured span four orders of magnitude against the Group I {beta}-lactamase AmpC and three orders of magnitude against the Group II {beta}-lactamase TEM-1. The acylglycineboronic acids have K{sub i} values as low as 20 nM against AmpC and as low as 390 nM against TEM-1. The inhibitors showed little activity against serine proteases, such as chymotrypsin. R1 side chains characteristic of {beta}-lactam inhibitors did not have better affinity for AmpC than did side chains characteristic of {beta}-lactam substrates. Two of the inhibitors reversed the resistance of pathogenic bacteria to {beta}-lactams in cell culture. Structures of two inhibitors in their complexes with AmpC were determined by X-ray crystallography to 1.90 {angstrom} and 1.75 {angstrom} resolution; these structures suggest interactions that are important to the affinity of the inhibitors. Acylglycineboronic acids allow us to begin to dissect interaction energies between {beta}-lactam side chains and {beta}-lactamases. Surprisingly

  2. Bound beta-decay: BOB

    International Nuclear Information System (INIS)

    For many years exotic decay modes of the neutron have been investigated as possible doorways to the exploration of new physics. The bound beta-decay (BOB) of the neutron into a hydrogen atom and an anti-neutrino offers a very elegant method to study neutrino helicities. However, this rare decay has not yet been observed for the free neutron, owing to the challenge of measuring a decay involving only electrically neutral particles and with an estimated branching ratio of only a few 106 of the three-body decay mode. During the past few years scientists from the TUM E18 Group have developed a novel experimental scheme which addresses all necessary problems associated with the observation of this two-body neutron decay in a very coherent way. The BOB experiment shall be installed at a tangential beam tube of a powerful research reactor such as the SR6 at the FRMII in Garching or H6-H7 beam tube at ILL. This talk will provide insights and ideas on how such an experiment is to be performed.

  3. Dopamine beta-hydroxylase deficiency

    Directory of Open Access Journals (Sweden)

    Senard Jean-Michel

    2006-03-01

    Full Text Available Abstract Dopamine beta-hydroxylase (DβH deficiency is a very rare form of primary autonomic failure characterized by a complete absence of noradrenaline and adrenaline in plasma together with increased dopamine plasma levels. The prevalence of DβH deficiency is unknown. Only a limited number of cases with this disease have been reported. DβH deficiency is mainly characterized by cardiovascular disorders and severe orthostatic hypotension. First symptoms often start during a complicated perinatal period with hypotension, muscle hypotonia, hypothermia and hypoglycemia. Children with DβH deficiency exhibit reduced ability to exercise because of blood pressure inadaptation with exertion and syncope. Symptoms usually worsen progressively during late adolescence and early adulthood with severe orthostatic hypotension, eyelid ptosis, nasal stuffiness and sexual disorders. Limitation in standing tolerance, limited ability to exercise and traumatic morbidity related to falls and syncope may represent later evolution. The syndrome is caused by heterogeneous molecular alterations of the DBH gene and is inherited in an autosomal recessive manner. Restoration of plasma noradrenaline to the normal range can be achieved by therapy with the synthetic precursor of noradrenaline, L-threo-dihydroxyphenylserine (DOPS. Oral administration of 100 to 500 mg DOPS, twice or three times daily, increases blood pressure and reverses the orthostatic intolerance.

  4. Neutron bound {beta}- decay- BOB

    Energy Technology Data Exchange (ETDEWEB)

    Gabriel, M.; Berger, M.; Emmerich, R.; Faestermann, T.; Gutsmiedl, E.; Hartmann, F.J.; Paul, S.; Ruschel, S.; Schoen, J.; Schott, W.; Schubert, U.; Trautner, A. [Physik-Department, TUM, 85748 Garching (Germany); Engels, R. [Institut fuer Kernphysik, Forschungszentrum Juelich, 52425 Juelich (Germany); Fierlinger, P. [Excellence Cluster Universe, TUM, 85748 Garching (Germany); Hertenberger, R. [Sektion Physik, LMU, 85748 Garching (Germany); Roehrmoser, R. [FRM2, TUM, 85748 Garching (Germany); Udem, T. [Max-Planck-Institut fuer Quantenphysik, 85748 Garching (Germany)

    2011-07-01

    The bound neutron {beta}-decay(BOB) into a hydrogen atom and an electron antineutrino is investigated.The hyper-fine-state population of the monoenergetic hydrogen atoms (326.3 eV) yields the neutrino left-handed-ness or a possible right-handed admixture and possible small scalar and tensor contributions to the weak force. Preexperiments to measure the BOB H(2s) atoms have been done or are being set up using ionizer and RF discharge proton sources, a Wien filter, Cs and Ar cells, a spin filter, electric counter and accelerating fields, a double focusing magnet and a solar blind PM for the Lyman-{alpha} photons. In a first experiment, the charge exchange of the H(2s) atoms into H{sup -}, offering a selective method to discriminate these states against background, is investigated. In a second step the number of background H(2s) resulting from protons interacting with the walls of the experimental setup are determined. For this a quenching E field and a solar blind PM are used.

  5. Pressure phase lines and enthalpies for the. cap alpha. -. beta. and. beta. -liquid transitions in beryllium

    Energy Technology Data Exchange (ETDEWEB)

    Abey, A.

    1984-10-31

    The effect of hydrostatic pressure on the ..cap alpha..-..beta.. and ..beta..-liquid transition temperatures in Be was measured in a gas pressure system. Differential thermal analysis was used in the pressure range from 0.1 MPa to 0.7 GPa. For the ..cap alpha..-..beta.. transition, dT/dP = 43 +- 7 K/GPa; for the ..beta..-liquid transition, dT/dP = 35 +- 7 K/GPa. Although it is possible that large systematic errors may arise from experimental procedures, our results are seriously at odds with those of other investigators. Transition enthalpies for the ..cap alpha..-..beta.. and ..beta..-liquid transitions were 1.9 +- 0.2 and 2.2 +- 0.2 kcal/g.m., respectively, at a pressure of 0.1 MPa.

  6. A comparison of enzymatic phosphorylation and phosphatidylation of beta-L- and beta-D-nucleosides.

    Science.gov (United States)

    Birichevskaya, Larisa L; Kvach, Sergei V; Sivets, Grigorii G; Kalinichenko, Elena N; Zinchenko, Anatoly I; Mikhailopulo, Igor A

    2007-04-01

    Enzymatic 5'-monophosphorylation and 5'-phosphatidylation of a number of beta-L- and beta-D-nucleosides was investigated. The first reaction, catalyzed by nucleoside phosphotransferase (NPT) from Erwinia herbicola, consisted of the transfer of the phosphate residue from p-nitrophenylphosphate (p-NPP) to the 5'-hydroxyl group of nucleoside; the second was the phospholipase D (PLD)-catalyzed transphosphatidylation of L-alpha-lecithin with a series of beta-L- and beta-D-nucleosides as the phosphatidyl acceptor resulted in the formation of the respective phospholipid-nucleoside conjugates. Some beta-L-nucleosides displayed similar or even higher substrate activity compared to the beta-D-enantiomers. PMID:17206374

  7. Systematic Risk on Istanbul Stock Exchange: Traditional Beta Coefficient Versus Downside Beta Coefficient

    Directory of Open Access Journals (Sweden)

    Gülfen TUNA

    2013-03-01

    Full Text Available The aim of this study is to test the validity of Downside Capital Asset Pricing Model (D-CAPM on the ISE. At the same time, the explanatory power of CAPM's traditional beta and D-CAPM's downside beta on the changes in the average return values are examined comparatively. In this context, the monthly data for seventy three stocks that are continuously traded on the ISE for the period 1991-2009 is used. Regression analysis is applied in this study. The research results have shown that D-CAPM is valid on the ISE. In addition, it is obtained that the power of downside beta coefficient is higher than traditional beta coefficient on explaining the return changes. Therefore, it can be said that the downside beta is superior to traditional beta in the ISE for chosen period.

  8. Review of modern double beta decay experiments

    International Nuclear Information System (INIS)

    The review of modern experiments on search and studying of double beta decay processes is done. Results of the most sensitive current experiments are discussed. The main attention is paid to EXO-200, KamLAND-Zen, GERDA-I and CUORE-0 experiments. Modern values of T1/2(2ν) and best present limits on neutrinoless double beta decay and double beta decay with Majoron emission are presented. Conservative limits on effective mass of a Majorana neutrino (〈mν〉 < 0.46 eV) and a coupling constant of Majoron to neutrino (〈gee〉 < 1.3 · 10−5) are obtained. Prospects of search for neutrinoless double beta decay in new experiments with sensitivity to 〈mν〉 at the level of ∼ 0.01-0.1 eV are discussed

  9. Neutrino potential for neutrinoless double beta decay

    CERN Document Server

    Iwata, Yoritaka

    2016-01-01

    Neutrino potential for neutrinoless double beta decay is studied with focusing on its statistical property. The statistics provide a gross view of understanding amplitude of constitutional components of the nuclear matrix element.

  10. Literature in Focus Beta Beams: Neutrino Beams

    CERN Document Server

    2009-01-01

    By Mats Lindroos (CERN) and Mauro Mezzetto (INFN Padova, Italy) Imperial Press, 2009 The beta-beam concept for the generation of electron neutrino beams was first proposed by Piero Zucchelli in 2002. The idea created quite a stir, challenging the idea that intense neutrino beams only could be produced from the decay of pions or muons in classical neutrino beams facilities or in future neutrino factories. The concept initially struggled to make an impact but the hard work by many machine physicists, phenomenologists and theoreticians over the last five years has won the beta-beam a well-earned position as one of the frontrunners for a possible future world laboratory for high intensity neutrino oscillation physics. This is the first complete monograph on the beta-beam concept. The book describes both technical aspects and experimental aspects of the beta-beam, providing students and scientists with an insight into the possibilities o...

  11. Genetics Home Reference: beta-mannosidosis

    Science.gov (United States)

    ... depression, or have behavioral problems such as hyperactivity, impulsivity or aggression. People with beta-mannosidosis may experience ... and management of various health conditions: Diagnostic Tests Drug Therapy Surgery and Rehabilitation Genetic Counseling Palliative Care ...

  12. Review of modern double beta decay experiments

    Energy Technology Data Exchange (ETDEWEB)

    Barabash, A. S., E-mail: barabash@itep.ru [Institute of Theoretical and Experimental Physics (NRC ”Kurchatov Institute”), B. Cheremushkinskaya 25, Moscow (Russian Federation)

    2015-10-28

    The review of modern experiments on search and studying of double beta decay processes is done. Results of the most sensitive current experiments are discussed. The main attention is paid to EXO-200, KamLAND-Zen, GERDA-I and CUORE-0 experiments. Modern values of T{sub 1/2}(2ν) and best present limits on neutrinoless double beta decay and double beta decay with Majoron emission are presented. Conservative limits on effective mass of a Majorana neutrino (〈m{sub ν}〉 < 0.46 eV) and a coupling constant of Majoron to neutrino (〈g{sub ee}〉 < 1.3 · 10{sup −5}) are obtained. Prospects of search for neutrinoless double beta decay in new experiments with sensitivity to 〈m{sub ν}〉 at the level of ∼ 0.01-0.1 eV are discussed.

  13. Beta decay of highly charged ions

    International Nuclear Information System (INIS)

    Ion storage rings and ion traps provide the very first opportunity to address nuclear beta decay under conditions prevailing in hot stellar plasmas during nucleosynthesis, i.e. at high atomic charge states. Experiments are summarized that were performed in this field during the last decade at the ion storage-cooler ring ESR in Darmstadt. Special emphasis is given to the first observation of bound-state beta decay, where the created electron remains bound in an inner orbital of the daughter atom. The impact of this specific 'stellar' decay mode for s-process nucleosynthesis as well as for nuclear 'eon clocks' is outlined. Finally, a new technique, single-ion decay spectroscopy, is presented, where one observes two-body beta decay characteristics (i.e. orbital electron capture or bound-state beta decay) of highly charged, single ions for well-defined nuclear and atomic quantum states of both the mother - and the daughter - ion.

  14. High-Beta and very high-beta optics studies for the LHC

    CERN Document Server

    Faus-Golfe, A

    2004-01-01

    New high-beta and very high-beta optics have been sought in order to find the best possible configuration for measuring elastic scattering at the LHC. They are based on the nominal powering scheme of the low-beta triplet. A list of the various possible solutions is given in this report. A particularly interesting solution has been found for a case where the phase advance in both planes at the detector are clore to pi/2.

  15. Genetic counselling in the beta-thalassaemias

    OpenAIRE

    Ioannides, Adonis S.

    2013-01-01

    The beta-thalassaemias are very important genetic disorders of haemoglobin synthesis and are amongst the commonest monogenic disorders. In view of the severity of beta-thalassaemia major, a number of screening programmes have been developed aimed at reducing the number of individuals born with the condition. Genetic counsellingplays a vital role in this process supporting the successful implementation of screening and delineating available options to at risk individuals. This review assesses ...

  16. Searches for neutrinoless double beta decay

    Science.gov (United States)

    Schwingenheuer, Bernhard

    2012-07-01

    Neutrinoless double beta decay is a lepton number violating process whose observation would also establish that neutrinos are their own anti-particles. There are many experimental efforts with a variety of techniques. Some (EXO, Kamland-Zen, GERDA phase I and CANDLES) started take data in 2011 and EXO has reported the first measurement of the half life for the double beta decay with two neutrinos of 136Xe. The sensitivities of the different proposals are reviewed.

  17. Searches for neutrinoless double beta decay

    CERN Document Server

    Schwingenheuer, B

    2012-01-01

    Neutrinoless double beta decay is a lepton number violating process whose observation would also establish that neutrinos are their own anti-particles. There are many experimental efforts with a variety of techniques. Some (EXO, Kamland-Zen, GERDA phase I and CANDLES) started take data in 2011 and EXO has reported the first measurement of the half life for the double beta decay with two neutrinos of $^{136}$Xe. The sensitivities of the different proposals are reviewed.

  18. Micro-battery Development using beta radioisotope

    International Nuclear Information System (INIS)

    Nuclear battery which use the beta radiation sources emitting the low penetration radiation energy from radioisotope can be applied as the long term (more than 10 years) micro power source in MEMS and nano components. This report describes the basic concept and principles of nuclear micro-battery and its fabrication in space and military field. In particular direct conversion method is described by investigating the electron-hole generation and recombination in p-n junction of silicon betavoltaics with beta radiation

  19. Conditionally parametric fits for CAPM betas

    OpenAIRE

    Abberger, Klaus

    2004-01-01

    The CAPM model assumes stock returns to be a linear function of the market return. However, there is considerable evidence that the beta stability assumption commonly used when estimating the model is invalid. Nonparametric regression methods are used to examine the stability of beta coefficients in German stock returns. Since local polynomial regression is used for estimation, known methods for testing the stability and for bandwidth choice can be used. For some returns the test indicates ti...

  20. Unexpected pattern of beta-globin mutations in beta-thalassaemia patients from northern Portugal

    OpenAIRE

    Cabeda, J.; Correia, C.; Estevinho, A.; Simões, C.; Amorim, M; L. Pinho; Justiça, B

    1999-01-01

    We characterized the genetic nature of beta-thalassaemia in northern Portugal. Of the 164 patients studied three were beta-thalassaemia major cases (one IVS-1-6/beta degrees 39 and two homozygous IVS-1-110). The analysis of the frequency of each mutation in the families revealed that the codon 6(-A) mutation was unexpectedly frequent (40%) and associated with the beta-globin haplotype E, and not with the usual European and North African CD6(-A) haplotypes. In contrast, the frequency of IVS-1-...

  1. The effect of physical therapy on beta-endorphin levels.

    Science.gov (United States)

    Bender, Tamás; Nagy, György; Barna, István; Tefner, Ildikó; Kádas, Eva; Géher, Pál

    2007-07-01

    Beta-endorphin (betaE) is an important reliever of pain. Various stressors and certain modalities of physiotherapy are potent inducers of the release of endogenous betaE to the blood stream. Most forms of exercise also increase blood betaE level, especially when exercise intensity involves reaching the anaerobic threshold and is associated with the elevation of serum lactate level. Age, gender, and mental activity during exercise also may influence betaE levels. Publications on the potential stimulating effect of manual therapy and massage on betaE release are controversial. Sauna, mud bath, and thermal water increase betaE levels through conveying heat to the tissues. The majority of the techniques for electrical stimulation have a similar effect, which is exerted both centrally and--to a lesser extent--peripherally. However, the parameters of electrotherapy have not yet been standardised. The efficacy of analgesia and the improvement of general well-being do not necessarily correlate with betaE level. Although in addition to blood, increased brain and cerebrospinal fluid betaE levels are also associated with pain, the majority of studies have concerned blood betaE levels. In general, various modalities of physical therapy might influence endorphin levels in the serum or in the cerebrospinal fluid--this is usually manifested by elevation with potential mitigation of pain. However, a causal relationship between the elevation of blood, cerebrospinal fluid or brain betaE levels and the onset of the analgesic action cannot be demonstrated with certainty. PMID:17483960

  2. Beta adrenergic receptors in human cavernous tissue

    International Nuclear Information System (INIS)

    Beta adrenergic receptor binding was performed with 125I iodocyanopindolol on human cavernous tissue membrane fractions from normal tissue and transsexual procedures obtained postoperatively, as well as from postmortem sources. Isotherm binding studies on normal fresh tissues indicated that the receptor density was 9.1 fmoles/mg. with a KD of 23 pM. Tissue stored at room temperature for 4 to 6 hours, then at 4C in saline solution for 19 to 20 hours before freezing showed no significant changes in receptor density or affinity, and provided evidence for the stability of postmortem tissue obtained within the same time period. Beta receptor density of 2 cavernous preparations from transsexual procedures was not significantly different from normal control tissues, and showed that high concentrations of estrogen received by these patients had no effect on beta adrenergic receptor density. Displacement of 125iodocyanopindolol by 5 beta adrenergic agents demonstrated that 1-propranolol had the greatest affinity followed by ICI 118,551, zinterol, metoprolol and practolol. When the results of these displacement studies were subjected to Scatfit, non- linear regression line analysis, a single binding site was described. Based on the relative potency of the selective beta adrenergic agents it appears that these receptors were of the beta 2 subtype

  3. Beta adrenergic receptors in human cavernous tissue

    Energy Technology Data Exchange (ETDEWEB)

    Dhabuwala, C.B.; Ramakrishna, C.V.; Anderson, G.F.

    1985-04-01

    Beta adrenergic receptor binding was performed with /sup 125/I iodocyanopindolol on human cavernous tissue membrane fractions from normal tissue and transsexual procedures obtained postoperatively, as well as from postmortem sources. Isotherm binding studies on normal fresh tissues indicated that the receptor density was 9.1 fmoles/mg. with a KD of 23 pM. Tissue stored at room temperature for 4 to 6 hours, then at 4C in saline solution for 19 to 20 hours before freezing showed no significant changes in receptor density or affinity, and provided evidence for the stability of postmortem tissue obtained within the same time period. Beta receptor density of 2 cavernous preparations from transsexual procedures was not significantly different from normal control tissues, and showed that high concentrations of estrogen received by these patients had no effect on beta adrenergic receptor density. Displacement of /sup 125/iodocyanopindolol by 5 beta adrenergic agents demonstrated that 1-propranolol had the greatest affinity followed by ICI 118,551, zinterol, metoprolol and practolol. When the results of these displacement studies were subjected to Scatfit, non- linear regression line analysis, a single binding site was described. Based on the relative potency of the selective beta adrenergic agents it appears that these receptors were of the beta 2 subtype.

  4. Genetic analysis of beta1 integrin "activation motifs" in mice

    DEFF Research Database (Denmark)

    Czuchra, Aleksandra; Meyer, Hannelore; Legate, Kyle R;

    2006-01-01

    /beta tails, leading to tail separation and integrin activation. We analyzed mice in which we mutated the tyrosines of the beta1 tail and the membrane-proximal aspartic acid required for the salt bridge. Tyrosine-to-alanine substitutions abolished beta1 integrin functions and led to a beta1 integrin...

  5. The beta-adrenoceptors mediating relaxation of rat oesophageal muscularis mucosae are predominantly of the beta 3-, but also of the beta 2-subtype.

    OpenAIRE

    de Boer, R. E.; Brouwer, F.; Zaagsma, J

    1993-01-01

    1. beta-Adrenoceptor-mediated relaxation of rat oesophageal smooth muscle was investigated by studying the effects of beta 1- and beta 2-selective antagonists on the relaxation induced by (-)-isoprenaline, the beta 2-selective agonists fenoterol and clenbuterol and the beta 3-agonist, BRL 37344. 2. The highly beta 1-selective antagonist CGP 20721A did not antagonize (-)-isoprenaline- or BRL 37344-induced relaxations in concentrations up to 10 microM. Only at 100 microM of CGP 20712A were clea...

  6. News on $\\beta$-delayed particle emission from $^{14}$Be

    CERN Document Server

    Jeppesen, H; Borge, M J G; Cederkäll, J; Fynbo, H O U; Fedoseyev, V N; Hansper, V Y; Jonson, B; Markenroth, K; Mishin, V I; Nilsson, T; Nyman, G; Riisager, K; Tengblad, O; Wilhelmsen Rolander, K

    2002-01-01

    $\\beta$-delayed charged particles from $^{14}$Be have been measured and give an upper limit on $\\beta$-delayed $\\alpha$-particles of B($\\beta\\alpha$) < $\\,6.7\\times\\!10^{-5}$ and a tentative branching ratio on $\\beta$-delayed tritons of $7.5\\times\\!10^{-5}$ < B($\\beta$t) < $\\,3.9\\times\\!10^{-4}$. We combine the knowledge on $\\beta$-delayed particles from $^{14}$Be to deduce information on the $\\beta$-strength distribution.

  7. Beta-Negative Binomial Process and Poisson Factor Analysis

    OpenAIRE

    Zhou, Mingyuan; Hannah, Lauren; Dunson, David; Carin, Lawrence

    2011-01-01

    A beta-negative binomial (BNB) process is proposed, leading to a beta-gamma-Poisson process, which may be viewed as a "multi-scoop" generalization of the beta-Bernoulli process. The BNB process is augmented into a beta-gamma-gamma-Poisson hierarchical structure, and applied as a nonparametric Bayesian prior for an infinite Poisson factor analysis model. A finite approximation for the beta process Levy random measure is constructed for convenient implementation. Efficient MCMC computations are...

  8. Oligomerization and toxicity of A{beta} fusion proteins

    Energy Technology Data Exchange (ETDEWEB)

    Caine, Joanne M., E-mail: Jo.Caine@csiro.au [CSIRO Materials Science and Engineering and the Preventive Health Flagship, Parkville, Victoria (Australia); Bharadwaj, Prashant R. [CSIRO Materials Science and Engineering and the Preventive Health Flagship, Parkville, Victoria (Australia); Centre for Excellence for Alzheimer' s Disease Research and Care, School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Western Australia (Australia); Sankovich, Sonia E. [CSIRO Materials Science and Engineering and the Preventive Health Flagship, Parkville, Victoria (Australia); Ciccotosto, Giuseppe D. [The Department of Pathology and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Victoria 3010 (Australia); Streltsov, Victor A.; Varghese, Jose [CSIRO Materials Science and Engineering and the Preventive Health Flagship, Parkville, Victoria (Australia)

    2011-06-10

    Highlights: {yields} We expressed amyloid-{beta} (A{beta}) peptide as a soluble maltose binding protein fusion (MBP-A{beta}42 and MBP-A{beta}16). {yields} The full length A{beta} peptide fusion, MBP-A{beta}42, forms oligomeric species as determined by SDS-PAGE gels, gel filtration and DLS. {yields} The MBP-A{beta}42, but not MBP-A{beta}16 or MBP alone, is toxic to both yeast and mammalian cells as determined by toxicity assays. -- Abstract: This study has found that the Maltose binding protein A{beta}42 fusion protein (MBP-A{beta}42) forms soluble oligomers while the shorter MBP-A{beta}16 fusion and control MBP did not. MBP-A{beta}42, but neither MBP-A{beta}16 nor control MBP, was toxic in a dose-dependent manner in both yeast and primary cortical neuronal cells. This study demonstrates the potential utility of MBP-A{beta}42 as a reagent for drug screening assays in yeast and neuronal cell cultures and as a candidate for further A{beta}42 characterization.

  9. Beta Gyres in Global Analysis Fields

    Institute of Scientific and Technical Information of China (English)

    Sun-Hee KIM; H.Joe KWON; R.L.ELSBERRY

    2009-01-01

    A three-component decomposition is applied to global analysis data to show the existence of a beta gyre,which causes Tropical Cyclone (TC) to drift from a large-scale environmental steering current.Analyses from the Global Data Assimilation and Prediction System (GDAPS) of the Korea Meteorological Administration (KMA),the Global Forecast System (GFS) of NCEP,and the Navy Operational Global Atmospheric Prediction System (NOGAPS) are used in this study.The structure of the beta gyre obtained in our analyses is in good agreement with the theoretical structure,with a cyclonic circulation to the southwest of the TC center,an anticyclonic circulation to the northeast,and a ventilation flow directed northwestward near the center.The circulation of the beta gyre is strongest at the 850-hPa level where the cyclonically swirling primary circulation is strongest,and decreases with height,in a pyramid shape similar to the primary circulation.The individual structure of the beta gyre is case- and model-dependent.At a certain analysis time,one model may clearly reveal a well-defined beta gyre,but the other models may not.Within one model,the beta gyre may be well defined at some analysis times,but not at other times.The structure of the beta gyre in the analysis field is determined by the nature of the vortex initialization scheme and the model behavior during the 6-h forecast in the operational data assimilation cycle.

  10. Detrimental effects of beta-blockers in COPD - A concern for nonselective beta-blockers

    NARCIS (Netherlands)

    van der Woude, HJ; Zaagsma, J; Postma, DS; Winter, TH; van Hulst, M; Aalbers, R

    2005-01-01

    Introduction: beta-Blockers are known to worsen FEV1 and airway hyperresponsiveness (AHR) in patients with asthma. Both characteristics determine the outcome of COPD, a disease with frequent cardiac comorbidity requiring beta-blocker treatment. Design: A double-blind, placebo-controlled, randomized,

  11. Mrp2 is essential for estradiol-17 beta(beta-D-glucuronide)-induced cholestasis in rats

    NARCIS (Netherlands)

    Huang, LY; Smit, JW; Meijer, DKF; Vore, M

    2000-01-01

    The present study evaluates the roles of the multidrug resistance-1 P-glycoprotein, Mdr1a/1b, the bile salt export pump (Bsep), and the multidrug resistance-associated protein-2 (Mrp2) in mediating cholestasis induced by estradiol-17 beta(beta-D-glucuronide) (E(2)17G). Administration of [H-3]E(2)17G

  12. Production of beta-xylanase and beta-xylosidase by the extremely halophilic archaeon Halorhabdus utahensis

    DEFF Research Database (Denmark)

    Wainø, M.; Ingvorsen, K.

    2003-01-01

    The extremely halophilic archaeon, Halorhabdus utahensis, isolated from the Great Salt Lake, Utah, produced beta-xylanase and beta-xylosidase activities. Both enzymes were active over a broad NaCl range from near zero to 30% NaCl when tested with culture broth. A broad NaCl optimum was observed f...

  13. On Gamow-Teller strength distributions for $\\beta\\beta$-decaying nuclei within continuum-QRPA

    CERN Document Server

    Igashov, S Yu; Faessler, Amand; Urin, M H

    2010-01-01

    An isospin-selfconsistent pn-continuum-QRPA approach is formulated and applied to describe the Gamow-Teller strength distributions for $\\beta\\beta$-decaying open-shell nuclei. The calculation results obtained for the pairs of nuclei $^{76}$Ge-Se, $^{100}$Mo-Ru, $^{116}$Cd-Sn, and $^{130}$Te-Xe are compared with available experimental data.

  14. Competition of $\\beta$-delayed protons and $\\beta$-delayed $\\gamma$ rays in $^{56}$Zn and the exotic $\\beta$-delayed $\\gamma$-proton decay

    CERN Document Server

    Orrigo, S E A; Fujita, Y; Blank, B; Gelletly, W; Agramunt, J; Algora, A; Ascher, P; Bilgier, B; Cáceres, L; Cakirli, R B; Fujita, H; Ganioglu, E; Gerbaux, M; Giovinazzo, J; Grévy, S; Kamalou, O; Kozer, H C; Kucuk, L; Kurtukian-Nieto, T; Molina, F; Popescu, L; Rogers, A M; Susoy, G; Stodel, C; Suzuki, T; Tamii, A; Thomas, J C

    2016-01-01

    Remarkable results have been published recently on the $\\beta$ decay of $^{56}$Zn. In particular, the rare and exotic $\\beta$-delayed $\\gamma$-proton emission has been detected for the first time in the $fp$ shell. Here we focus the discussion on this exotic decay mode and on the observed competition between $\\beta$-delayed protons and $\\beta$-delayed $\\gamma$ rays from the Isobaric Analogue State.

  15. Regulation of glycogen synthase kinase-3{beta} (GSK-3{beta}) after ionizing radiation; Regulation der Glykogen Synthase Kinase-3{beta} (GSK-3{beta}) nach ionisierender Strahlung

    Energy Technology Data Exchange (ETDEWEB)

    Boehme, K.A.

    2006-12-15

    Glycogen Synthase Kinase-3{beta} (GSK-3{beta}) phosphorylates the Mdm2 protein in the central domain. This phosphorylation is absolutely required for p53 degradation. Ionizing radiation inactivates GSK-3{beta} by phosphorylation at serine 9 and in consequence prevents Mdm2 mediated p53 degradation. During the work for my PhD I identified Akt/PKB as the kinase that phosphorylates GSK-3{beta} at serine 9 after ionizing radiation. Ionizing radiation leads to phosphorylation of Akt/PKB at threonine 308 and serine 473. The PI3 Kinase inhibitor LY294002 completely abolished Akt/PKB serine 473 phosphorylation and prevented the induction of GSK-3{beta} serine 9 phosphorylation after ionizing radiation. Interestingly, the most significant activation of Akt/PKB after ionizing radiation occurred in the nucleus while cytoplasmic Akt/PKB was only weakly activated after radiation. By using siRNA, I showed that Akt1/PKBa, but not Akt2/PKB{beta}, is required for phosphorylation of GSK- 3{beta} at serine 9 after ionizing radiation. Phosphorylation and activation of Akt/PKB after ionizing radiation depends on the DNA dependent protein kinase (DNA-PK), a member of the PI3 Kinase family, that is activated by free DNA ends. Both, in cells from SCID mice and after knockdown of the catalytic subunit of DNA-PK by siRNA in osteosarcoma cells, phosphorylation of Akt/PKB at serine 473 and of GSK-3{beta} at serine 9 was completely abolished. Consistent with the principle that phosphorylation of GSK-3 at serine 9 contributes to p53 stabilization after radiation, the accumulation of p53 in response to ionizing radiation was largely prevented by downregulation of DNA-PK. From these results I conclude, that ionizing radiation induces a signaling cascade that leads to Akt1/PKBa activation mediated by DNA-PK dependent phosphorylation of serine 473. After activation Akt1/PKBa phosphorylates and inhibits GSK-3{beta} in the nucleus. The resulting hypophosphorylated form of Mdm2 protein is no longer

  16. Closed-form expressions for moments of a class of beta generalized distributions

    OpenAIRE

    Cordeiro, Gauss M.; Nadarajah, Saralees

    2011-01-01

    For the first time, we derive explicit closed-form expressions for moments of some beta generalized distributions including the beta gamma, beta normal, beta beta, beta Student t and beta F distributions. These expressions are given as infinite weighted sums of well-known special functions for which numerical routines for computation are available.

  17. Neutrinoless double beta decay from lattice QCD

    CERN Document Server

    Nicholson, Amy; Chang, Chia Cheng; Clark, M A; Joo, Balint; Kurth, Thorsten; Rinaldi, Enrico; Tiburzi, Brian; Vranas, Pavlos; Walker-Loud, Andre

    2016-01-01

    While the discovery of non-zero neutrino masses is one of the most important accomplishments by physicists in the past century, it is still unknown how and in what form these masses arise. Lepton number-violating neutrinoless double beta decay is a natural consequence of Majorana neutrinos and many BSM theories, and many experimental efforts are involved in the search for these processes. Understanding how neutrinoless double beta decay would manifest in nuclear environments is key for understanding any observed signals. In these proceedings we present an overview of a set of one- and two-body matrix elements relevant for experimental searches for neutrinoless double beta decay, describe the role of lattice QCD calculations, and present preliminary lattice QCD results.

  18. Calibration of beta dosimeter and personal dosimeter

    International Nuclear Information System (INIS)

    This paper introduces ISO standard ISO 6980 which prepared especially for the calibration of beta dosimeter and personal dosimeter. The standard has three aspects including method of production of reference beta particle radiations, calibration fundamentals related to basic quantities characterizing the radiation field, and calibration of area and personal dosemters and the determination of their response as a function of beta radiation energy and angle of incidence. Here particular emphasis is placed on the determination of basic quantity of tissue absorbed dose at a depth of 0.07 mm in the tissue slab phantom and calibration procedure by mean of the calibration quantity of directional dose equivalent H'(0.07, Ω) and personal dose equivalent Hp (0.07, Ω). Finally, combined standard uncertainty for the determination of absorbed dose rate and component uncertainties of calibration is given as examples. (authors)

  19. Tevatron B0 low beta tuning report

    International Nuclear Information System (INIS)

    A detailed study of the low beta insertion for the B0 experimental area has been carried out and is described below. This insertion is similar to the Type C low beta previously report, anti p Note 169, although some changes have been made to the quadrupole lengths and positions. This insertion is designated Type E. The purpose of the study was to see if it is possible to turn the insertion on in a smooth and continuous manner and tune the insertion to a value of β* of less than one meter while maintaining the overall tune of the j Tevatron to a constant value. This was found to be possible. An examination of chromaticity corrections for the Tevatron with the low beta insertion on in various configurations was also undertaken

  20. BETASCAN: probable beta-amyloids identified by pairwise probabilistic analysis.

    Directory of Open Access Journals (Sweden)

    Allen W Bryan

    2009-03-01

    Full Text Available Amyloids and prion proteins are clinically and biologically important beta-structures, whose supersecondary structures are difficult to determine by standard experimental or computational means. In addition, significant conformational heterogeneity is known or suspected to exist in many amyloid fibrils. Recent work has indicated the utility of pairwise probabilistic statistics in beta-structure prediction. We develop here a new strategy for beta-structure prediction, emphasizing the determination of beta-strands and pairs of beta-strands as fundamental units of beta-structure. Our program, BETASCAN, calculates likelihood scores for potential beta-strands and strand-pairs based on correlations observed in parallel beta-sheets. The program then determines the strands and pairs with the greatest local likelihood for all of the sequence's potential beta-structures. BETASCAN suggests multiple alternate folding patterns and assigns relative a priori probabilities based solely on amino acid sequence, probability tables, and pre-chosen parameters. The algorithm compares favorably with the results of previous algorithms (BETAPRO, PASTA, SALSA, TANGO, and Zyggregator in beta-structure prediction and amyloid propensity prediction. Accurate prediction is demonstrated for experimentally determined amyloid beta-structures, for a set of known beta-aggregates, and for the parallel beta-strands of beta-helices, amyloid-like globular proteins. BETASCAN is able both to detect beta-strands with higher sensitivity and to detect the edges of beta-strands in a richly beta-like sequence. For two proteins (Abeta and Het-s, there exist multiple sets of experimental data implying contradictory structures; BETASCAN is able to detect each competing structure as a potential structure variant. The ability to correlate multiple alternate beta-structures to experiment opens the possibility of computational investigation of prion strains and structural heterogeneity of amyloid

  1. beta2-Agonists at the Olympic Games.

    Science.gov (United States)

    Fitch, Kenneth D

    2006-01-01

    The different approaches that the International Olympic Committee (IOC) had adopted to beta2-agonists and the implications for athletes are reviewed by a former Olympic team physician who later became a member of the Medical Commission of the IOC (IOC-MC). Steadily increasing knowledge of the effects of inhaled beta2-agonists on health, is concerned with the fact that oral beta2-agonists may be anabolic, and rapid increased use of inhaled beta2-agonists by elite athletes has contributed to the changes to the IOC rules. Since 2001, the necessity for athletes to meet IOC criteria (i.e., that they have asthma and/or exercise-induced asthma [EIA]) has resulted in improved management of athletes. The prevalence of beta2-agonist use by athletes mirrors the known prevalence of asthma symptoms in each country, although athletes in endurance events have the highest prevalence. The age-of-onset of asthma/EIA in elite winter athletes may be atypical. Of the 193 athletes at the 2006 Winter Olympics who met th IOC's criteria, only 32.1% had childhood asthma and 48.7% of athletes reported onset at age 20 yr or older. These findings lead to speculation that years of intense endurance training may be a causative factor in bronchial hyperreactivity. The distinction between oral (prohibited in sports) and inhaled salbutamol is possible, but athletes must be warned that excessive use of inhaled salbutamol can lead to urinary concentrations similar to those observed after oral administration. This article provides justification that athletes should provide evidence of asthma or EIA before being permitted to use inhaled beta2-agonists. PMID:17085798

  2. Beta/gamma test problems for ITS

    International Nuclear Information System (INIS)

    The Integrated Tiger Series of Coupled Electron/Photon Monte Carlo Transport Codes (ITS 3.0, PC Version) was used at Oak Ridge National Laboratory (ORNL) to compare with and extend the experimental findings of the beta/gamma response of selected health physics instruments. In order to assure that ITS gives correct results, several beta/gamma problems have been tested. ITS was used to simulate these problems numerically, and results for each were compared to the problem's experimental or analytical results. ITS successfully predicted the experimental or analytical results of all tested problems within the statistical uncertainty inherent in the Monte Carlo method

  3. Double-Beta Decay at TUNL

    Science.gov (United States)

    Kidd, Mary

    2007-10-01

    Studying double-beta decay at Triangle Universities Nuclear Laboratory (TUNL) is perhaps one of the most promising ways to pinpoint the neutrino mass. What they do not mention is that to study double-beta decay, you probably have to become a certified miner, and if you have a fear of goats, you should stay away. In this talk, I will tell you some of my experiences as a TUNL graduate student, and how I am now nearly qualified for a job in the mining industry.

  4. Microscopic calculations for rare beta decays

    OpenAIRE

    Mustonen, Mika

    2010-01-01

    In this thesis consisting of six publications and an overview part, three cases of rare beta decays are studied using microscopic nuclear models. Firstly, the half-lives and electron spectra of 113Cd and 115In fourth-forbidden nonunique ground-state-to-ground-state beta decays are studied using two closely related nuclear models: The microscopic quasiparticle-phonon model (MQPM) and the proton-neutron MQPM (pnMQPM), which has been developed as a part of this thesis work. Our...

  5. Nuclear beta decay after Les Houches

    International Nuclear Information System (INIS)

    Wilkinson's 1977 Les Houches lectures summarized in detail how nuclear beta decay can be used to investigate fundamental nuclear phenomena and the achievements of this utilization up to that time. In this short talk the subsequent activity is briefly summarized and one area of high activity, namely first-forbidden beta decay, is singled out for more lengthy discussion. Specifically, the subject of interest is the very large meson exchange contribution to the time-like component of the axial current and the efforts to isolate this enhancement by means of careful shell-model calculations. 19 refs., 4 figs., 2 tabs

  6. Survey instrument response to beta radiations

    International Nuclear Information System (INIS)

    Available survey instruments do not have the beta measurement characteristics needed for accurate dose rate assessments. Such instruments have severe angular and energy dependence. In addition, beta measurements often require corrections for the source geometry response of the detector to permit accurate assessments. Studies were performed to characterize present instruments and to determine optimum characteristics for a field instrument. Results of the studies were used to specify and procure an instrument with improved characteristics. The purpose of this paper is to describe the results of the studies and the design of the instrument

  7. Survey instrument response to beta radiations

    International Nuclear Information System (INIS)

    Available survey instruments do not have the beta measurement characteristics needed for accurate dose rate assessments. Such instruments have severe angular and energy dependence. In addition, beta measurements often require corrections for the source geometry response of the detector to permit accurate assessments. Studies were performed to characterize present instruments and to determine optimum characteristics for a field instrument. Results of the studies were used to specify and procure an instrument with improved characteristics. The purpose of this paper is to describe the results of the studies and the design of the instrument. 6 refs., 6 figs., 4 tabs

  8. Why search for double beta decay?

    International Nuclear Information System (INIS)

    Searching for neutrinoless double beta decay is the only known practical method for trying to determine whether neutrinos are their own antiparticles. The theoretical motivation for supposing that they may indeed be their own antiparticles is described. The reason that it is so difficult to ascertain experimentally whether they are or are not is explained, as is the special sensitivity of neutrinoless double beta decay. The potential implications of the observation of this reaction for neutrino mass and for the physics of neutrinos is discussed

  9. Helicity and nuclear $\\beta$ decay correlations

    CERN Document Server

    Hong, Ran; García, Alejandro

    2016-01-01

    We present simple derivations of nuclear $\\beta$-decay correlations with an emphasis on the special role of helicity. This provides a good opportunity to teach students about helicity and chirality in particle physics through exercises using simple aspects of quantum mechanics. In addition, this paper serves as an introduction to nuclear $\\beta$-decay correlations from both a theoretical and experimental vantage. This article can be used to introduce students to ongoing experiments searching for hints of new physics in the low-energy precision frontier.

  10. Card controlled beta backscatter thickness measuring instrument

    International Nuclear Information System (INIS)

    An improved beta backscatter instrument for the nondestructive measurement of the thickness of thin coatings on a substrate is described. Included therein is the utilization of a bank of memory stored data representative of isotope, substrate, coating material and thickness range characteristics in association with a control card having predetermined indicia thereon selectively representative of a particular isotope, substrate material, coating material and thickness range for conditioning electronic circuit means by memory stored data selected in accord with the predetermined indicia on a control card for converting backscattered beta particle counts into indicia of coating thickness

  11. Supermultiplet of $\\beta-$deformations from twistors

    CERN Document Server

    Milián, Segundo P

    2016-01-01

    We consider the supermultiplet of linearized beta-deformation of $\\mathcal{N}=4$ Super Yang-Mills(SYM). It was previously studied on the gravitational side. We study the supermultiplet of beta-deformations on the field theory side and we compare two finite-dimensional representations of $psl(4|4,\\bf{R})$ algebra. We show that they are related by an intertwining operator. We develop a twistor-based approach which could be useful for studying other finite-dimensional and nonunitary representations in AdS/CFT correspondence.

  12. Symmetry violations in nuclear and neutron $\\beta$ decay

    CERN Document Server

    Vos, K K; Timmermans, R G E

    2015-01-01

    The role of $\\beta$ decay as a low-energy probe of physics beyond the Standard Model is reviewed. Traditional searches for deviations from the Standard Model structure of the weak interaction in $\\beta$ decay are discussed in the light of constraints from the LHC and the neutrino mass. Limits on the violation of time-reversal symmetry in $\\beta$ decay are compared to the strong constraints from electric dipole moments. Novel searches for Lorentz symmetry breaking in the weak interaction in $\\beta$ decay are also included, where we discuss the unique sensitivity of $\\beta$ decay to test Lorentz invariance. We end with a roadmap for future $\\beta$-decay experiments.

  13. COBRA - Double beta decay searches using CdTe detectors

    OpenAIRE

    Zuber, K.

    2001-01-01

    A new approach (called COBRA) for investigating double beta decay using CdTe (CdZnTe) semiconductor detectors is proposed. It follows the idea that source and detector are identical. This will allow simultaneous measurements of 5 $\\beta^-\\beta^-$ - and 4 $\\beta^+\\beta^+$ - emitters at once. Half-life limits for neutrinoless double beta decay of Cd-116 and Te-130 can be improved by more than one order of magnitude with respect to current limits and sensitivities on the effective Majorana neutr...

  14. Molecular and chemical comparison of beta/sub 2/ and beta/sub 2/ adrenergic receptors

    Energy Technology Data Exchange (ETDEWEB)

    Shorr, R.G.L.; Gotlib, L.; Varrichio, A.; Strohsacker, M.; Minnich, M.; Crooke, S.T.

    1986-05-01

    Beta-adrenergic receptor proteins of 55,000M/sub r/ and 45,000M/sub r/ have been purified from rabbit lung, guinea pig lung, bovine lung and turkey red blood cell plasma membranes by affinity chromatography, size exclusion high performance liquid chromatography and preparative SDS polyacrylamide gel electrophoresis. Each purified receptor was characterized with agonists and selective antagonists in ligand binding competition experiments with (/sup 125/I) cyanopindolol as being of the ..beta../sub 1/ or ..beta../sub 2/ adrenergic receptor subclass. Purified rabbit lung, guinea pig lung and bovine lung were all found to be of the ..beta../sub 2/ receptor subclass. Purified turkey RBC receptor was of the ..beta../sub 1/ subclass. When compared by molecular weight, each of the receptor proteins was found to comigrate on SDS polyacylamide gels with its counterpart from the additional tissues. When the proteins were compared by amino acid composition similar results were obtained for each of the receptors. These results suggest significant levels of sequence homology between the avian ..beta../sub 1/ adrenergic receptor and the mammalian ..beta../sub 2/ adrenergic receptor preparations.

  15. Human liver alcohol dehydrogenase. 1. The primary structure of the beta 1 beta 1 isoenzyme.

    Science.gov (United States)

    Hempel, J; Bühler, R; Kaiser, R; Holmquist, B; de Zalenski, C; von Wartburg, J P; Vallee, B; Jörnvall, H

    1984-12-17

    Determination of the amino acid sequence of the beta 1 subunit from the class I (pyrazole-sensitive) human liver alcohol dehydrogenase isoenzyme beta 1 beta 1 revealed a 373-residue structure differing at 48 positions (including a gap) from that of the subunit of the well studied horse liver alcohol dehydrogenase EE isoenzyme. The structure deduced is compatible with known differences in composition, ultraviolet absorbance, electrophoretic mobility and catalytic properties between the horse and human enzymes. All zinc-liganding residues of the horse E subunit are strictly conserved in the human beta 1 subunit, despite an earlier report of a mutation involving Cys-46. This residue therefore remains conserved in all known alcohol dehydrogenase structures. However, the total cysteine content of the beta 1 structure is raised from 14 in the subunit of the horse enzyme to 15 by a Tyr----Cys exchange. Most exchanges are on the surface of the molecule and of a well conserved nature. Substitutions close to the catalytic centre are of interest to explain the altered substrate specificity and different catalytic activity of the beta 1 homodimer. Functionally, a Ser----Thr exchange at position 48 appears to be of special importance, since Thr-48 in beta 1 instead of Ser-48 in the horse enzyme can restrict available space. Four other substitutions also line the active-site pocket, and appear to constitute partly compensated exchanges. PMID:6391920

  16. Use of multi-element TL dosimeters for beta and mixed beta/gamma personnel monitoring

    International Nuclear Information System (INIS)

    Applied experience as well as theoretical considerations make it clear that traditional two-element TL dosimeters are not adequate for use in personnel dosimetry involving beta radiation fields. The principal shortcoming of such dosimeters is that the TL element measuring the beta dose normally under responds, and the readings of such elements must be multiplied by a correction factor, called the beta factor, to obtain the dose. The beta factor, however, is not a constant but varies with variations in the beta spectrum incident on the dosimeter. Experimental tests carried out using a number of multi-element TL dosimeter designs have shown that the element readouts can be used in conjunction with a suitable algorithm to determine a suitable beta factor for use under a variety of irradiation conditions. The precision attainable in calculating the beta factor in this manner depends on a number of dosimeter design parameters and is often quite poor unless special care is exercised both in the design of the dosimeter and also in the operation of the readout system

  17. Nuclear Matrix Elements for the $\\beta\\beta$ Decay of the $^{76}$Ge

    CERN Document Server

    Brown, B A; Horoi, M

    2015-01-01

    The nuclear matrix elements for two-neutrino double-beta (2 n$\\beta\\beta$ ) and zero-neutrino double-beta (0 n$\\beta\\beta$) decay of 76 Ge are evaluated in terms of the configuration interaction (CI), quasiparticle random phase approximation (QRPA) and interacting boson model (IBM) methods. We show that the decomposition of the matrix elements in terms of interemediate states in 74 Ge is dominated by ground state of this nucleus. We consider corrections to the CI results that arise from configurations admixtures involving orbitals out-side of the CI configuration space by using results from QRPA, many-body-perturbation theory, and the connections to related observables. The CI two-neutrino matrix element is reduced due to the inclusion of spin-orbit partners, and to many-body correlations connected with Gamow-Teller beta decay. The CI zero-neutrino matrix element for the heavy neutrino is enhanced due to particle-particle correlations that are connected with the odd-even oscillations in the nuclear masse...

  18. Massaspectrometrische analyse van enkele beta-agonisten

    OpenAIRE

    Traag, W.A.; Kienhuis, P.G.M.; Tuinstra, L.G.M.T.; Bennekom, van, C.A.M.; Huf, F.A.

    1990-01-01

    Zes beta-agonisten (isoproterenol, clenbuterol, cimaterol, terbutaline, salbutamol en fenoterol) zijn als TMS-derivaten onderzocht op hun GeMS-eigenschappen in zowel de Electron Impact (EI) als positieve Chemische Ionisatie mode (Cl). Tevens is clenbuterol-hexyl onderzocht. Deze component is geschikt om als interne standaard te fungeren.

  19. Association behavior of native beta-lactoglobulin

    DEFF Research Database (Denmark)

    Verheul, M.; Pedersen, J.S.; Roefs, S.P.F.M.; Kruif, K.G. de

    1999-01-01

    samples were obtained. These functions provided information on the maximum size, the weight-averaged molecular mass, and the z-averaged radius of gyration oo the the beta-lactoglobulin particles. Al room temperature and pH values below 4 and above IZ the protein consists predominantly of monomers and...

  20. Herwig++ 2.0beta Release Note

    OpenAIRE

    Gieseke, Stefan; Grellscheid, D.; Ribon, Alberto; Richardson, P.; Seymour, Michael H.; Stephens, Phil; Webber, Bryan R

    2006-01-01

    A new release of the Monte Carlo program Herwig++ (version 2.0beta) is now available. The main new feature is the extension of the program to include simple hadron-hadron processes including the initial-state parton shower.

  1. Characterization of a Commercial Silicon Beta Cell

    Energy Technology Data Exchange (ETDEWEB)

    Foxe, Michael P. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hayes, James C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Mayer, Michael F. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); McIntyre, Justin I. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Sivels, Ciara B. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Suarez, Rey [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2016-03-31

    Silicon detectors are of interest for the verification of the Comprehensive Nuclear-Test-Ban Treaty (CTBT) due to their enhanced energy resolution compared to plastic scintillators beta cells. Previous work developing a figure-of-merit (FOM) for comparison of beta cells suggests that the minimum detectable activity (MDA) could be reduced by a factor of two to three with the use of silicon detectors. Silicon beta cells have been developed by CEA (France) and Lares Ltd. (Russia), with the PIPSBox developed by CEA being commercially available from Canberra for approximately $35k, but there is still uncertainty about the reproducibility of the capabilities in the field. PNNL is developing a high-resolution beta-gamma detector system in the shallow underground laboratory, which will utilize and characterize the operation of the PIPSBox detector. Throughout this report, we examine the capabilities of the PIPSBox as developed by CEA. The lessons learned through the testing and use of the PIPSBox will allow PNNL to strategically develop a silicon detector optimized to better suit the communities needs in the future.

  2. Nuclear physics issues in double beta decay

    International Nuclear Information System (INIS)

    A number of issues in double beta decay are discussed: shell model estimates of 2nu matrix elements, a sum rule for the double Gamow-Teller operator, a comparison of shell model and quasiparticle RPA results, Pontecorvo's Te ratio argument, neutrinoless ββ decay mediated by heavy neutrinos, and the structure of O+ states in Ge isotopes. 24 refs., 3 figs

  3. Average beta measurement in EXTRAP T1

    International Nuclear Information System (INIS)

    Beginning with the ideal MHD pressure balance equation, an expression for the average poloidal beta, ΒΘ, is derived. A method for unobtrusively measuring the quantities used to evaluate ΒΘ in Extrap T1 is described. The results if a series of measurements yielding ΒΘ as a function of externally applied toroidal field are presented. (author)

  4. Topical beta-Blockers and Mortality

    NARCIS (Netherlands)

    Muskens, Rogier P. H. M.; Wolfs, Roger C. W.; Wittenian, Jacqueline C. M.; Hofman, Albert; de Jong, Paulus T. V. M.; Stricker, Bruno H. C.; Jansonius, Nomdo M.

    2008-01-01

    Purpose: To study the associations between long-term and short-term use of topical beta-blockers and mortality. Design: Prospective population-based cohort study. Participants: To examine long-term effects, 3842 participants aged 55 years and older were recruited. To examine short-term effects, 484

  5. Redox Homeostasis in Pancreatic beta Cells

    Czech Academy of Sciences Publication Activity Database

    Ježek, Petr; Dlasková, Andrea; Plecitá-Hlavatá, Lydie

    2012-01-01

    Roč. 2012, č. 2012 (2012), s. 932838. ISSN 1942-0900 R&D Projects: GA ČR(CZ) GAP302/10/0346; GA ČR(CZ) GPP304/10/P204 Institutional support: RVO:67985823 Keywords : beta cells * reactive oxygen species homeostasis * mitochondria Subject RIV: FB - Endocrinology, Diabetology, Metabolism, Nutrition Impact factor: 3.393, year: 2012

  6. Semiconductor detectors and double beta decay

    International Nuclear Information System (INIS)

    The underlying theory of double beta decay is discussed as well as some experimental observations. A class of second generation 76Ge detector experiments is then discussed. The design and physics considerations involved in the system used by LBL are explained, particularly the means of rejecting background activity. 24 references, 18 figures, 3 tables

  7. Multiple nerve palsies in beta thalassaemia major.

    OpenAIRE

    Lamabadusuriya, S. P.

    1989-01-01

    A patient with beta thalassaemia major is described who developed a lower motor neurone facial nerve palsy on the left side, together with a phrenic nerve palsy on the same side, during the course of the illness. This complication has not been reported before in haemoglobinopathies.

  8. LHC dijet constraints on double beta decay

    CERN Document Server

    Helo, J C

    2015-01-01

    We use LHC dijet data to derive constraints on neutrinoless double beta decay. Upper limits on cross sections for the production of "exotic" resonances, such as a right-handed W boson or a diquark, can be converted into lower limits on the double beta decay half-life for fixed choices of other parameters. Constraints derived from run-I data are already surprisingly strong and complementary to results from searches using same-sign dileptons plus jets. For the case of the left-right symmetric model, in case no new resonance is found in future runs of the LHC and assuming $g_L=g_R$, we estimate a lower limit on the double beta decay half-live larger than $10^{27}$ ys can be derived from future dijet data, except in the window of relatively light right-handed neutrino masses in the range $0.5$ MeV to $50$ GeV. Part of this mass window will be tested in the upcoming SHiP experiment. We also discuss current and future limits on possible scalar diquark contributions to double beta decay that can be derived from dije...

  9. Double beta decay: A theoretical overview

    Energy Technology Data Exchange (ETDEWEB)

    Rosen, S.P.

    1988-01-01

    This paper reviews the theoretical possibility of double beta decay. The titles of the main sections of this paper are: Nuclear physics setting; Particle physics requirements; Kinematical features of the decay modes; Nuclear matrix elements; the Shell model and two-neutrino decay; Quasi-particle random phase approximation; and Future considerations. 18 refs., 7 tabs. (LSP)

  10. Frameshift mutation events in beta-glucosidases.

    Science.gov (United States)

    Rojas, Antonio; Garcia-Vallvé, Santiago; Montero, Miguel A; Arola, Lluís; Romeu, Antoni

    2003-09-18

    Compensated frameshift mutation is a modification of the reading frame of a gene that takes place by way of various molecular events. It appears to be a widespread event that is only observed when homologous amino acid and nucleodotide sequences are compared. To identify these mutation events, the sequence analysis rationale was based on the search for short regions that would have much lower degrees of conservation in protein, but not in DNA, in well-conserved beta-glucosidase families. We have restricted our study to a seed set of sequences of O-glycoside hydrolase families 1 and 3. We found compensated frameshift mutation in the family of 1 beta-glucosidases for the Erwinia herbicola, Cellulomonas fimi, and (non-cyanogenic) Trifolium repens gene sequences, and in the family of 3 beta-glucosidases for the Clostridium thermocellum and Clostridium stercorarium gene sequences. By computational treatment, the observed mutation events in the gene frameshifting sub-sequence have been neutralised. Each nucleotide insertion must be eliminated and each nucleotide deletion must be substituted by the symbol N (any nucleotide). When the frameshifting fragments of the amino acid sequences were substituted by the computationally neutralised subsequences, the beta-glucosidase alignments were improved. We also discuss the structural implications of the compensated frameshift mutations events. PMID:14527732

  11. Sources of beta cells inside the pancreas.

    Science.gov (United States)

    De Groef, Sofie; Staels, Willem; Van Gassen, Naomi; Lemper, Marie; Yuchi, Yixing; Sojoodi, Mozhdeh; Bussche, Leen; Heremans, Yves; Leuckx, Gunter; De Leu, Nico; Van de Casteele, Mark; Baeyens, Luc; Heimberg, Harry

    2016-09-01

    The generation of beta(-like) cells to compensate for their absolute or relative shortage in type 1 and type 2 diabetes is an obvious therapeutic strategy. Patients first received grafts of donor islet cells over 25 years ago, but this procedure has not become routine in clinical practice because of a donor cell shortage and (auto)immune problems. Transplantation of differentiated embryonic and induced pluripotent stem cells may overcome some but not all the current limitations. Reprogramming exocrine cells towards functional beta(-like) cells would offer an alternative abundant and autologous source of beta(-like) cells. This review focuses on work by our research group towards achieving such a source of cells. It summarises a presentation given at the 'Can we make a better beta cell?' symposium at the 2015 annual meeting of the EASD. It is accompanied by two other reviews on topics from this symposium (by Amin Ardestani and Kathrin Maedler, DOI: 10.1007/s00125-016-3892-9 , and by Heiko Lickert and colleagues, DOI: 10.1007/s00125-016-3949-9 ) and a commentary by the Session Chair, Shanta Persaud (DOI: 10.1007/s00125-016-3870-2 ). PMID:27053238

  12. Three loop QCD MOM beta-functions

    CERN Document Server

    Gracey, J A

    2011-01-01

    We present the full expressions for the QCD beta-function in the MOMggg, MOMq and MOMh renormalization schemes at three loops for an arbitrary colour group in the Landau gauge. The results for all three schemes are in very good agreement with the SU(3) numerical estimates provided by Chetyrkin and Seidensticker.

  13. Lepton nonconservation and double beta decay

    International Nuclear Information System (INIS)

    This paper reviews the status of double beta decay as a test of lepton number conservation. Present limits on the mass of a Majorana neutrino are in the range of 10 to 50 eV. Experiments now in progress should substantially improve these limits

  14. Association behavior of native beta-lactoglobulin

    DEFF Research Database (Denmark)

    Verheul, M.; Pedersen, J.S.; Roefs, S.P.F.M.;

    1999-01-01

    The association behavior of beta-lactoglobulin has been studied by small-angle neutron scattering as a function of protein concentration, temperature, pH, and NaCl concentration of the solution. By indirect Fourier transformation of the spectra, pair-distance distribution functions for the various...

  15. Long term prospects for double beta decay

    OpenAIRE

    Zuber, K.

    2010-01-01

    In rather general terms the long term perspective of double beta decay is discussed. All important experimental parameters are investigated as well as the status of nuclear matrix element issues. The link with other neutrino physics results and options to disentangle the underlying physics process are presented.

  16. Weak interaction studies from nuclear beta decay

    International Nuclear Information System (INIS)

    The studies performed at the theoretical nuclear physics division of the Laboratory of Nuclear Studies, Osaka University, are reported. Electron spin density and internal conversion process, nuclear excitation by electron transition, beta decay, weak charged current, and beta-ray angular distributions in oriented nuclei have been studied. The relative intensity of internal conversion electrons for the case in which the radial wave functions of orbital electrons are different for electron spin up and down was calculated. The calculated value was in good agreement with the experimental one. The nuclear excitation following the transition of orbital electrons was studied. The calculated probability of the nuclear excitation of Os189 was 1.4 x 10-7 in conformity with the experimental value 1.7 x 10-7. The second class current and other problems on beta-decay have been extensively studied, and described elsewhere. Concerning weak charged current, the effects of all induced terms, the time component of main axial vector, all partial waves of leptons, Coulomb correction for the electrons in finite size nuclei, and radiative correction were studied. The beta-ray angular distribution for the 1+ -- 0+ transition in oriented B12 and N12 was investigated. In this connection, investigation on the weak magnetism to include all higher order corrections for the evaluation of the spectral shape factors was performed. Other works carried out by the author and his collaborators are also explained. (Kato, T.)

  17. Plastic bronchitis in beta thalassemia minor

    OpenAIRE

    Makaresh Yadav; Sneha Tirpude; Joshi, Jyotsna M.

    2013-01-01

    Plastic bronchitis is a rare pulmonary disorder associated with various conditions like cystic fibrosis, asthma, pulmonary infection and characterized by formation and expectoration of cast which assumes the shape of the bronchial tree. We report a case of a 33-year-old woman with beta thalassemia minor who developed plastic bronchitis.

  18. Estimation error algorithm at analysis of beta-spectra

    International Nuclear Information System (INIS)

    This work describes the estimation error algorithm at the operations with beta-spectrums, as well as compares the theoretical and experimental errors by the processing of beta-channel's data. (authors)

  19. Binding capacity of a barley beta-D-glucan to the beta-glucan recognition molecule dectin-1.

    Science.gov (United States)

    Tada, Rui; Adachi, Yoshiyuki; Ishibashi, Ken-ichi; Tsubaki, Kazufumi; Ohno, Naohito

    2008-02-27

    To clarify whether barley beta-glucans exhibit their biological effects via binding to dectin-1, a pivotal receptor for beta-1,3-glucan, the structure of barley beta-glucan E70-S (BBG-70) was unambiguously investigated by NMR spectroscopy and studied for its binding capacity and specificity to dectin-1 by ELISA. NMR spectroscopy confirmed that BBG-70 contains two different linkage glucans, namely, alpha-glucan and beta-glucan, which are not covalently attached to one another. Beta-glucan within BBG-70 is a linear mixed-linkage beta-glucan composed of 1,3- and 1,4-beta-D-glucopyranose residues but does not contain the continuous 1,3-linkage. Competitive ELISA revealed that highly purified barley beta-glucan E70-S (pBBG-70) inhibits the binding of soluble dectin-1 to sonifilan (SPG), a beta-1,3-glucan, although at a concentration higher than that of SPG and laminarin. It was found that barley beta-glucan can be recognized by dectin-1, implying that barley beta-glucan might, at least in part, exhibit its biological effects via the recognition by dectin-1 of the ligand sugar structure, which may be formed by 1,3-beta- and 1,4-beta-glucosyl linkage. PMID:18205312

  20. RESEARCH OF BETA AS ADEQUATE RISK MEASURE-IS BETA STILL ALIVE?

    Directory of Open Access Journals (Sweden)

    Ante Perković

    2011-02-01

    Full Text Available The capital asset pricing model (CAPM is one of the most important models in financial economics and it has a long history of theoretical and empirical investigations. The main underlying concept of the CAPM model is that assets with a high risk (high beta should earn a higher return than assets with a low risk (low beta and vice versa. The implication which can be drawn out of this is that all assets with a beta above zero bear some risk and therefore their expected return is above the return of the risk-free rate. In this research observation on monthly stock prices on Croatian stock market from January 1st 2005 until December 31st 2009 is used to form our sample. CROBEX index is used as proxy of the market portfolio. The results demonstrate that beta can not be trusted in making investment decisions and rejects the validity of the whole CAPM model on Croatian stock market.

  1. Ordinary muon capture as a probe of virtual transitions of $\\beta\\beta$ decay

    CERN Document Server

    Kortelainen, M

    2002-01-01

    A reliable theoretical description of double-beta-decay processes needs a possibility to test the involved virtual transitions against experimental data. Unfortunately, only the lowest virtual transition can be probed by the traditional electron-capture or $\\beta^-$-decay experiments. In this article we propose that calculated amplitudes for many virtual transitions can be probed by experiments measuring rates of ordinary muon capture (OMC) to the relevant intermediate states. The first results from such experiments are expected to appear soon. As an example we discuss the $\\beta\\beta$ decays of $^{76}$Ge and $^{106}$Cd and the corresponding OMC for the $^{76}$Se and $^{106}$Cd nuclei in the framework of the proton-neutron QRPA with realistic interactions. It is found that the OMC observables, just like the $2\

  2. Parametrizing the exoplanet eccentricity distribution with the Beta distribution

    OpenAIRE

    Kipping, David M.

    2013-01-01

    It is suggested that the distribution of orbital eccentricities for extrasolar planets is well-described by the Beta distribution. Several properties of the Beta distribution make it a powerful tool for this purpose. For example, the Beta distribution can reproduce a diverse range of probability density functions (PDFs) using just two shape parameters (a and b). We argue that this makes it ideal for serving as a parametric model in Bayesian comparative population analysis. The Beta distributi...

  3. Isolation and characterization of chicken and turkey beta 2-microglobulin

    DEFF Research Database (Denmark)

    Skjødt, K; Welinder, K G; Crone, M;

    1986-01-01

    Chicken and turkey beta 2-m were isolated from citrated plasma in sequential use of three chromatographic steps: affinity chromatography, gel filtration chromatography and anion-exchange chromatography. The purified protein was identified as beta 2-m by reaction with a beta 2-m specific monoclonal...... incompatible with a previously published sequence also thought to be from turkey beta 2-m. Reasons for our opinion that the molecules isolated and sequenced in this paper are the correct ones are given. Udgivelsesdato: 1986-Dec...

  4. Extended Beta Regression in R: Shaken, Stirred, Mixed, and Partitioned

    OpenAIRE

    Bettina Grün; Ioannis Kosmidis; Achim Zeileis

    2012-01-01

    Beta regression - an increasingly popular approach for modeling rates and proportions - is extended in various directions: (a) bias correction/reduction of the maximum likelihood estimator, (b) beta regression tree models by means of recursive partitioning, (c) latent class beta regression by means of finite mixture models. All three extensions may be of importance for enhancing the beta regression toolbox in practice to provide more reliable inference and capture both observed and unobserved...

  5. Functional beta3-adrenoceptor in the human heart.

    OpenAIRE

    Gauthier, C.; Tavernier, G.; Charpentier, F.; Langin, D.; Le Marec, H

    1996-01-01

    Beta3-adrenoceptors are involved in metabolism, gut relaxation, and vascular vasodilation. However, their existence and role in the human heart have not been documented. We investigated the effects of several beta-adrenoceptor agonists and antagonists on the mechanical properties of ventricular endomyocardial biopsies. In the presence of nadolol, a beta1- and beta2-adrenoceptor antagonist, isoprenaline produced consistent negative inotropic effects. Similar negative inotropic effects also res...

  6. Milk composition and lactation of beta-casein-deficient mice.

    OpenAIRE

    Kumar, S.; Clarke, A R; Hooper, M L; Horne, D S; Law, A J; Leaver, J; Springbett, A; Stevenson, E.; Simons, J.P.

    1994-01-01

    beta-Casein is a major protein component of milk and, in conjunction with the other caseins, it is assembled into micelles. The casein micelles determine many of the physical characteristics of milk, which are important for stability during storage and for milk-processing properties. There is evidence that suggests that beta-casein may also possess other, nonnutritional functions. To address the function of beta-casein, the mouse beta-casein gene was disrupted by gene targeting in embryonic s...

  7. A guide to 17beta-hydroxysteroid dehydrogenases.

    Science.gov (United States)

    Adamski, J; Jakob, F J

    2001-01-22

    17beta-Hydroxysteroid dehydrogenases (17beta-HSD) are pivotal in controlling the biological potency of steroid hormones by catalyzing oxidation or reduction at position 17. Several 17beta-HSDs may as well metabolize further substrates including alcohols, bile acids, fatty acids and retinols. This review summarizes recent progress in the field of 17beta-HSD research provides an update of nomenclature. PMID:11165003

  8. International Society of Sports Nutrition Position Stand: beta-hydroxy-beta-methylbutyrate (HMB)

    OpenAIRE

    Wilson Jacob M; Fitschen Peter J; Campbell Bill; Wilson Gabriel J; Zanchi Nelo; Taylor Lem; Wilborn Colin; Kalman Douglas S; Stout Jeffrey R; Hoffman Jay R; Ziegenfuss Tim N; Lopez Hector L; Kreider Richard B; Smith-Ryan Abbie E; Antonio Jose

    2013-01-01

    Abstract Position Statement: The International Society of Sports Nutrition (ISSN) bases the following position stand on a critical analysis of the literature on the use of beta-hydroxy-beta-methylbutyrate (HMB) as a nutritional supplement. The ISSN has concluded the following. 1. HMB can be used to enhance recovery by attenuating exercise induced skeletal muscle damage in trained and untrained populations. 2. If consuming HMB, an athlete will benefit from consuming the supplement in close pro...

  9. Interleukin-1 beta (IL-1 beta) induces thrombocytosis in mice: Possible implication of IL-6

    Energy Technology Data Exchange (ETDEWEB)

    Kimura, H.; Ishibashi, T.; Shikama, Y.; Okano, A.; Akiyama, Y.; Uchida, T.; Maruyama, Y. (Fukushima Medical College (Japan))

    1990-12-15

    We administered recombinant human interleukin-1 beta (IL-1 beta), the common mediator of inflammation process, to C57B1/6 male mice (0.5 microgram, every 12 hours over five times) intraperitoneally and consequently induced a remarkable thrombocytosis. Day 1 was designated as the following day of the last injection in the morning. A significant thrombocytosis was observed on days 1 through 5 with a peak on day 2 (162 +/- 9 x 10(4)/mm3) compared with the control mice injected with heated IL-1 beta (101 +/- 11 x 10(4)/mm3). A striking increase in mean size of marrow megakaryocytes was noted on days 1 and 2. The incorporation of 75Se-selenomethionine into circulating platelets as a measure of platelet production was about 2.3 times higher in IL-1 beta-treated mice than in control mice. To determine which factor(s) is responsible for elicited thrombocytosis, the in vitro studies and bioassays for several hematopoietic factors were performed. IL-1 beta by itself did not stimulate megakaryocytopoiesis in vitro, suggesting that the thrombocytosis is attributed to other factor(s) via IL-1 beta stimulation. Serum colony-stimulating factor (CSF) activity after a single IL-1 beta (0.5 microgram) injection, monitored by colony assay with 10% tested serum, peaked at 3 hours. Formed colonies were mostly granulocyte (G) and granulocyte-macrophage (GM)-types, and studies using rabbit anti-mouse GM-CSF serum or using human marrow as target cells showed that the CSF activity of the tested serum consisted of, at least, GM-CSF and G-CSF. Addition of IL-3 concomitantly with the tested serum gave rise to a greater number of megakaryocytic colonies. Serum IL-3, monitored by IL-3-dependent cell line 32D clone 5, and erythropoietin activities were not detected at serum level in IL-1 beta-treated mice.

  10. Interleukin-1 beta (IL-1 beta) induces thrombocytosis in mice: Possible implication of IL-6

    International Nuclear Information System (INIS)

    We administered recombinant human interleukin-1 beta (IL-1 beta), the common mediator of inflammation process, to C57B1/6 male mice (0.5 microgram, every 12 hours over five times) intraperitoneally and consequently induced a remarkable thrombocytosis. Day 1 was designated as the following day of the last injection in the morning. A significant thrombocytosis was observed on days 1 through 5 with a peak on day 2 (162 +/- 9 x 10(4)/mm3) compared with the control mice injected with heated IL-1 beta (101 +/- 11 x 10(4)/mm3). A striking increase in mean size of marrow megakaryocytes was noted on days 1 and 2. The incorporation of 75Se-selenomethionine into circulating platelets as a measure of platelet production was about 2.3 times higher in IL-1 beta-treated mice than in control mice. To determine which factor(s) is responsible for elicited thrombocytosis, the in vitro studies and bioassays for several hematopoietic factors were performed. IL-1 beta by itself did not stimulate megakaryocytopoiesis in vitro, suggesting that the thrombocytosis is attributed to other factor(s) via IL-1 beta stimulation. Serum colony-stimulating factor (CSF) activity after a single IL-1 beta (0.5 microgram) injection, monitored by colony assay with 10% tested serum, peaked at 3 hours. Formed colonies were mostly granulocyte (G) and granulocyte-macrophage (GM)-types, and studies using rabbit anti-mouse GM-CSF serum or using human marrow as target cells showed that the CSF activity of the tested serum consisted of, at least, GM-CSF and G-CSF. Addition of IL-3 concomitantly with the tested serum gave rise to a greater number of megakaryocytic colonies. Serum IL-3, monitored by IL-3-dependent cell line 32D clone 5, and erythropoietin activities were not detected at serum level in IL-1 beta-treated mice

  11. Problems at the Development of personal Beta-particle dosemeters-Beta Particle dosemeters-

    International Nuclear Information System (INIS)

    Workplaces at which beta radiation might significantly contribute to the doses to the extremities are increasingly found in radiation therapy, radiation source production and nuclear plants. for the measurement of the individual beta-particle dose, personal dosemeters for fingers, arms and legs are needed. Intercomparison measurements organised from 1996 by the PTB have shown that some dosemeter types based on TLD are suitable for this purpose and can be used as legal dosemeters for both photon and beta radiation. Also, some electronic personal photon dosemeters are investigated in beta radiation fields. it turned out that a few types are also sensitive to beta radiation and measure the personal dose equivalent rate to the skin with a low energy dependence. Only their wearing position is by far not optimal foe extremity dosimetry because they are worn on the chest. Advantages and disadvantages are discussed. The characterisation of workplaces is carried out by measuring dose profiles using area dosemeters. Investigations performed with several commercial types of these dosemeters furnish information about the selection of the suitable measuring device and its correct practical use. the development of improved dosemeters has to towards smaller detectors and higher sensitivity. Personal dosemeters have to be robust and acceptable to the user, which generally is not achieved for beta extremity dosemeters. It is an additional problem that even such dosemeters cannot always be worn in the appropriate place. (Author)

  12. [beta]-Lactamases in the Biochemistry and Molecular Biology Laboratory

    Science.gov (United States)

    Amador, Paula; Prudencio, Cristina; Vieira, Monica; Ferraz, Ricardo; Fonte, Rosalia; Silva, Nuno; Coelho, Pedro; Fernandes, Ruben

    2009-01-01

    [beta]-lactamases are hydrolytic enzymes that inactivate the [beta]-lactam ring of antibiotics such as penicillins and cephalosporins. The major diversity of studies carried out until now have mainly focused on the characterization of [beta]-lactamases recovered among clinical isolates of Gram-positive staphylococci and Gram-negative…

  13. Natalizumab plus interferon beta-1a for relapsing multiple sclerosis.

    NARCIS (Netherlands)

    Rudick, R.A.; Stuart, W.H.; Calabresi, P.A.; Confavreux, C.; Galetta, S.L.; Radue, E.W.; Lublin, F.D.; Weinstock-Guttman, B.; Wynn, D.R.; Lynn, F.; Panzara, M.A.; Sandrock, A.W.

    2006-01-01

    BACKGROUND: Interferon beta is used to modify the course of relapsing multiple sclerosis. Despite interferon beta therapy, many patients have relapses. Natalizumab, an alpha4 integrin antagonist, appeared to be safe and effective alone and when added to interferon beta-1a in preliminary studies. MET

  14. Why Downside Beta Is Better: An Educational Example

    Science.gov (United States)

    Chong, James T.; Jennings, William P.; Phillips, G. Michael

    2013-01-01

    An educational example is presented that is an effective teaching illustration to help students understand the difference between traditional CAPM beta and downside (or down-market) beta and why downside beta is a superior measure for use in personal financial planning investment policy statements.

  15. Induction of beta-lactamase production in Pseudomonas aeruginosa biofilm

    DEFF Research Database (Denmark)

    Giwercman, B; Jensen, E T; Høiby, N;

    1991-01-01

    Imipenem induced high levels of beta-lactamase production in Pseudomonas aeruginosa biofilms. Piperacillin also induced beta-lactamase production in these biofilms but to a lesser degree. The combination of beta-lactamase production with other protective properties of the biofilm mode of growth...

  16. Mechanisms of beta-amyloid neurotoxicity : Perspectives of pharmacotherapy

    NARCIS (Netherlands)

    Harkany, T; Abraham, [No Value; Konya, C; Nyakas, C; Zarandi, M; Penke, B; Luiten, PGM

    2000-01-01

    One of the characteristic neuropathological hallmarks of Alzheimer's disease (AD) is the extracellular accumulation of beta -amyloid peptides (A beta) in neuritic plaques, Experimental data indicate that different molecular forms of A beta affect a wide array of neuronal and glial functions and ther

  17. 21 CFR 886.5100 - Ophthalmic beta radiation source.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Ophthalmic beta radiation source. 886.5100 Section... (CONTINUED) MEDICAL DEVICES OPHTHALMIC DEVICES Therapeutic Devices § 886.5100 Ophthalmic beta radiation source. (a) Identification. An ophthalmic beta radiation source is a device intended to apply...

  18. Transforming growth factor beta 1 (TGF-beta 1) induced neutrophil recruitment to synovial tissues: implications for TGF-beta-driven synovial inflammation and hyperplasia

    International Nuclear Information System (INIS)

    We have studied the consequences of introducing human recombinant transforming growth factor beta 1 (hrTGF-beta 1) into synovial tissue of the rat, to begin to better understand the significance of the fact that biologically active TGF-beta is found in human arthritic synovial effusions. Within 4-6 h after the intra-articular injection of 1 microgram of hrTGF-beta 1 into rat knee joints, extensive recruitment of polymorphonuclear leukocytes (PMNs) was observed. Cytochemistry and high resolution histological techniques were used to quantitate the influx of PMNs, which peaked 6 h post-injection. In a Boyden chamber assay, hrTGF-beta 1 at 1-10 fg/ml elicited a chemotactic response from PMNs greater in magnitude than that evoked by FMLP, establishing that TGF-beta 1 is an effective chemotactic agent for PMNs in vitro as well as in vivo. That PMNs may represent an important source of TGF-beta in inflammatory infiltrates was strongly suggested by a demonstration that stored TGF-beta 1 was secreted during phorbol myristate acetate-stimulated degranulation in vitro. Acid/ethanol extracts of human PMNs assayed by ELISA contained an average of 355 ng of TGF/beta 1 per 10(9) cells potentially available for secretion during degranulation of PMNs. [3H]Thymidine incorporation in vivo and autoradiography of tissue sections revealed that widespread cell proliferation was triggered by TGF-beta 1 injection. Synovial lining cells and cells located deep within the subsynovial connective tissue were identified as sources of at least some of the new cells that contribute to TGF-beta 1-induced hyperplasia. Our results demonstrate that TGF-beta is capable of exerting pathogenic effects on synovial tissue and that PMNs may represent a significant source of the TGF-beta present in synovial effusions

  19. Beta-hypergeometric probability distribution on symmetric matrices

    OpenAIRE

    Hassairi, Abdelhamid; Masmoudi, Mouna

    2012-01-01

    Some remarkable properties of the beta distribution are based on relations involving independence between beta random variables such that a parameter of one among them is the sum of the parameters of an other (see (1.1) et (1.2) below). Asci, Letac and Piccioni \\cite{6} have used the real beta-hypergeometric distribution on $ \\reel$ to give a general version of these properties without the condition on the parameters. In the present paper, we extend the properties of the real beta to the beta...

  20. Double beta decay with large scale Yb-loaded scintillators

    OpenAIRE

    Zuber, K.

    2000-01-01

    The potential of large scale Yb-loaded liquid scintillators as proposed for solar neutrino spectroscopy are investigated with respect to double beta decay. The potential for beta-beta- - decay of 176Yb as well as the beta+/EC - decay for 168Yb is discussed. Not only getting for the first time an experimental half-life limit on 176Yb - decay, this will even be at least comparable or better than existing ones from other isotopes. Also for the first time a realistic chance to detect beta+/EC - d...

  1. Role of the beta1-integrin cytoplasmic tail in mediating invasin-promoted internalization of Yersinia

    DEFF Research Database (Denmark)

    Gustavsson, Anna; Armulik, Annika; Brakebusch, Cord;

    2002-01-01

    1B or different mutants of the beta1A subunit was used. Both beta1A and beta1B bound to invasin-expressing bacteria, but only beta1A was able to mediate internalization of the bacteria. The cytoplasmic region of beta1A, differing from beta1B, contains two NPXY motifs surrounding a double threonine...

  2. 6 beta-Iodopenicillanic acid (UI-38,006), a beta-lactamase inhibitor that extends the antibacterial spectrum of beta-lactam compounds: initial bacteriological characterization.

    OpenAIRE

    Moore, B A; Brammer, K W

    1981-01-01

    UK-38,006, 6 beta-iodopenicillanic acid, was shown to be a potent inhibitor of beta-lactamase enzymes. It potentiated the antibacterial action of ampicillin in vitro against beta-lactamase-producing strains of Staphylococcus aureus, Haemophilus influenzae, Bacteroides fragilis. Neisseria gonorrhoeae, and many Enterobacteriaceae. This ability to synergize with ampicillin was also demonstrated in vivo after oral administration of UK-38,006 to experimentally infected mice. UK-38,006 was also sho...

  3. Bactericidal interactions of a beta-lactam and beta-lactamase inhibitors in experimental Pseudomonas aeruginosa endocarditis caused by a constitutive overproducer of type Id beta-lactamase.

    OpenAIRE

    Bayer, A S; Selecky, M; Babel, K; Hirano, L; Yih, J; Parr, T R

    1987-01-01

    We investigated the in vitro and in vivo effects of a combination of a beta-lactam (ceftazidime) and a beta-lactamase inhibitor (dicloxacillin) to synergistically kill a ceftazidime-resistant variant, Pseudomonas aeruginosa PA-48, which overproduces type Id cephalosporinase constitutively. In vitro, dicloxacillin plus ceftazidime exerted bactericidal synergy at approximately 10(5) CFU/ml of inoculum (but not at approximately 10(7)-CFU inoculum), whereas other beta-lactamase inhibitors (sulbac...

  4. Search for $\\beta^+$EC and ECEC processes in $^{112}$Sn and $\\beta^-\\beta^-$ decay of $^{124}$Sn to the excited states of $^{124}$Te

    CERN Document Server

    Barabash, A S; Nachab, A; Konovalov, S I; Vanyushin, I A; Umatov, V I

    2008-01-01

    Limits on $\\beta^+$EC and ECEC processes in $^{112}$Sn and on $\\beta^-\\beta^-$ decay of $^{124}$Sn to the excited states of $^{124}$Te have been obtained using a 380 cm$^3$ HPGe detector and an external source consisting of natural tin. A limit with 90% C.L. on the $^{112}$Sn half-life of $0.92\\times 10^{20}$ y for the ECEC(0$\

  5. Comparative evaluation of a new beta-lactamase inhibitor, YTR 830, combined with different beta-lactam antibiotics against bacteria harboring known beta-lactamases.

    OpenAIRE

    Gutmann, L; Kitzis, M D; Yamabe, S; Acar, J F

    1986-01-01

    YTR 830, a new beta-lactamase inhibitor, combined with amoxicillin or carbenicillin, showed a synergistic effect similar to that observed with clavulanic acid, and generally better than that with sulbactam, against strains harboring chromosome-encoded penicillinases and broad-spectrum beta-lactamases or plasmid-determined beta-lactamases. With ampicillin, YTR 830 showed the best synergistic activity of the inhibitors against Proteus morganii, Citrobacter freundii, and Enterobacter cloacae and...

  6. Genetic counselling in the beta-thalassaemias

    Directory of Open Access Journals (Sweden)

    Adonis S. Ioannides

    2013-03-01

    Full Text Available The beta-thalassaemias are very important genetic disorders of haemoglobin synthesis and are amongst the commonest monogenic disorders. In view of the severity of beta-thalassaemia major, a number of screening programmes have been developed aimed at reducing the number of individuals born with the condition. Genetic counsellingplays a vital role in this process supporting the successful implementation of screening and delineating available options to at risk individuals. This review assesses the contribution of genetic counsellingat each stage of this process in the context of new diagnostic techniques and therapeutic options and discusses some of the more challenging aspects such as genotype/ phenotype correlation and coinheritance of other genetic conditions or genetic modifiers.

  7. JUNO and neutrinoless double beta decay

    Science.gov (United States)

    Ge, Shao-Feng; Rodejohann, Werner

    2015-11-01

    We study the impact of the precision determination of oscillation parameters in the JUNO experiment on half-life predictions for neutrinoless double beta decay. We show that the solar neutrino mixing angle can be measured by JUNO with below 1% uncertainty. This implies in particular that the minimal value of the effective mass in the inverted mass ordering will be known essentially without uncertainty. We demonstrate that this reduces the range of half-life predictions in order to test this value by a factor of 2. The remaining uncertainty is caused by nuclear matrix elements. This has important consequences for future double beta decay experiments that aim at ruling out the inverted mass ordering or the Majorana nature of neutrinos.

  8. JUNO and Neutrinoless Double Beta Decay

    CERN Document Server

    Ge, Shao-Feng

    2015-01-01

    We study the impact of the precision determination of oscillation parameters in the JUNO experiment on half-life predictions for neutrinoless double beta decay. We show that the solar neutrino mixing angle can be measured by JUNO with below 1% uncertainty. This implies in particular that the minimal value of the effective mass in the inverted mass ordering will be known essentially without uncertainty. We demonstrate that this reduces the range of half-life predictions in order to test this value by a factor of two. The remaining uncertainty is caused by nuclear matrix elements. This has important consequences for future double beta decay experiments that aim at ruling out the inverted mass ordering or the Majorana nature of neutrinos.

  9. Importance of neutrinoless double beta decay

    CERN Document Server

    Sarkar, Utpal

    2007-01-01

    A natural explanation for the smallness of the neutrino mass requires them to be Majorana particles violating lepton number by two units. Since lepton number violation can have several interesting consequences in particle physics and cosmology, it is of utmost importance to find out if there is lepton number violation in nature and what is its magnitude. The neutrinoless double beta decay experiment can answer these questions: if there is lepton number violation and if neutrinos are Majorana particles. In addition, the magnitude of neutrinoless double beta decay will constrain any other lepton number violating processes. This lepton number violation may also be relatd to the matter-antimatter asymmetry of the universe, dark matter and cosmological constant.

  10. Beta-plane turbulence: experiments with altimetry

    CERN Document Server

    Zhang, Y

    2013-01-01

    Results from a new series of experiments on flows generated by an electromagnetic method in a rotating tank with topographic beta-effect are presented. The velocity fields are measured by the Altimetric Imaging Velocimetry. The turbulent flows observed in the experiments develop zonal jets which are latent in a stationary forced-dissipative regime of the flow but become prominent in the decaying flow. The two-dimensional energy spectra of the flows exhibit the development of anisotropy towards zonal motions. The experiments demonstrate dual turbulent cascade with energy and enstrophy ranges. The frequency-wavenumber spectra reveal the presence of Rossby waves at low wavenumbers which are excited by the turbulent motions. The experimental results are compared with available theory of beta-plane turbulence.

  11. Search for Neutrinoless Double-Beta Decay

    CERN Document Server

    Tornow, Werner

    2014-01-01

    After the pioneering work of the Heidelberg-Moscow (HDM) and International Germanium Experiment (IGEX) groups, the second round of neutrinoless double-$\\beta$ decay searches currently underway has or will improve the life-time limits of double-$\\beta$ decay candidates by a factor of two to three, reaching in the near future the $T_{1/2} = 3 \\times 10^{25}$ yr level. This talk will focus on the large-scale experiments GERDA, EXO-200, and KamLAND-Zen, which have reported already lower half-life time limits in excess of $10^{25}$ yr. Special emphasis is given to KamLAND-Zen, which is expected to approach the inverted hierarchy regime before future 1-ton experiments probe completely this life-time or effective neutrino-mass regime, which starts at $\\approx 2 \\times 10^{26}$ yr or $\\approx 50$ meV.

  12. Numerical models for high beta magnetohydrodynamic flow

    International Nuclear Information System (INIS)

    The fundamentals of numerical magnetohydrodynamics for highly conducting, high-beta plasmas are outlined. The discussions emphasize the physical properties of the flow, and how elementary concepts in numerical analysis can be applied to the construction of finite difference approximations that capture these features. The linear and nonlinear stability of explicit and implicit differencing in time is examined, the origin and effect of numerical diffusion in the calculation of convective transport is described, and a technique for maintaining solenoidality in the magnetic field is developed. Many of the points are illustrated by numerical examples. The techniques described are applicable to the time-dependent, high-beta flows normally encountered in magnetically confined plasmas, plasma switches, and space and astrophysical plasmas. 40 refs

  13. Source preparations for alpha and beta measurements

    Energy Technology Data Exchange (ETDEWEB)

    Holm, E. [Risoe National Lab., Roskilde (Denmark)

    2001-01-01

    Regarding alpha particle emitters subject for environmental studies, electrodeposition or co-precipitation as fluorides are the most common methods. For electro deposition stainless steel is generally used as cathode material but also other metals such as Ni, Ag, and Cu showed promising results. The use of other anode material than platinum, such as graphite should be investigated. For other purposes such as optimal resolution other more sophisticated methods are used but often resulting in poorer recovery. For beta particle emitters the type of detection system will decide the source preparation. Similar methods as for alpha particle emitters, electrodeposition or precipitation techniques can be used. Due to the continuous energy distribution of the beta pulse height distribution a high resolution is not required. Thicker sources from the precipitates or a stable isotopic carrier can be accepted but correction for absorption in the source must be done. (au)

  14. Source preparations for alpha and beta measurements

    International Nuclear Information System (INIS)

    Regarding alpha particle emitters subject for environmental studies, electrodeposition or co-precipitation as fluorides are the most common methods. For electro deposition stainless steel is generally used as cathode material but also other metals such as Ni, Ag, and Cu showed promising results. The use of other anode material than platinum, such as graphite should be investigated. For other purposes such as optimal resolution other more sophisticated methods are used but often resulting in poorer recovery. For beta particle emitters the type of detection system will decide the source preparation. Similar methods as for alpha particle emitters, electrodeposition or precipitation techniques can be used. Due to the continuous energy distribution of the beta pulse height distribution a high resolution is not required. Thicker sources from the precipitates or a stable isotopic carrier can be accepted but correction for absorption in the source must be done. (au)

  15. Beta Beams for Precision Measurements of Neutrino Oscillation Parameters

    CERN Document Server

    Wildner, E; Hansen, C; De Melo Mendonca, T; Stora, T; Damjanovic, S; Payet, J; Chancé, A; Zorin, V; Izotov, I; Rasin, S; Sidorov, A; Skalyga, V; De Angelis, G; Prete, G; Cinausero, M; Kravchuk, V; Gramegna, F; Marchi, T; Collazuol, G; Mezzetto, M; Delbar, T; Loiselet, M; Keutgen, T; Mitrofanov, S; Burt, G; Dexter, A; Lamy, T; Latrasse, L; Marie-Jeanne, M; Sortais, P; Thuillier, T; Debray, F; Trophime, C; Hass, M; Hirsh, T; Berkovits, D; Stahl, A; Vardaci, E; Di Nitto, A; Brondi, A; La Rana, G; Moro, R; De Rosa, G; Palladino, V

    2012-01-01

    Neutrino oscillations have implications for the Standard Model of particle physics. The CERN Beta Beam has outstanding capabilities to contribute to precision measurements of the parameters governing neutrino oscillations. The FP7 collaboration EUROnu (2008-2012) is a design study that will review three facilities (Super-Beams, Beta Beams and Neutrino Factories) and perform a cost assessment that, coupled with the physics performance, will give means to the European research authorities to make decisions on future European neutrino oscillation facilities. ”Beta Beams” produce collimated pure electron (anti)neutrinos by accelerating beta active ions to high energies and having them decay in a storage ring. Using existing machines and infrastructure is an advantage for the cost evaluation; however, this choice is also constraining the Beta Beams. Recent work to make the Beta Beam facility a solid option will be described: production of Beta Beam isotopes, the 60 GHz pulsed ECR source development, integratio...

  16. Evaluation of cyclohexenoesculetin-beta-D-galactoside and 8-hydroxyquinoline-beta-D-galactoside as substrates for the detection of beta-galactosidase.

    OpenAIRE

    James, A.L.; Perry, J D; Ford, M.; Armstrong, L.; Gould, F K

    1996-01-01

    We describe the synthesis of two new substrates for the detection of beta-galactosidase and evaluate their performance in comparison with that of 5-bromo-4-chloro-3-indolyl-beta-D-galactopyranoside (X-Gal). Of 171 Enterobacteriaceae strains that were able to hydrolyze X-Gal, 166 (97.1%) also hydrolyzed cyclohexenoesculetin-beta-D-galactoside whereas only 96 (56.1%) showed evidence of hydrolysis of 8-hydroxyquinoline-beta-D-galactoside. No false-positive results were observed with either subst...

  17. Antianginal Actions of Beta-Adrenoceptor Antagonists

    OpenAIRE

    O'Rourke, Stephen T.

    2007-01-01

    Angina pectoris is usually the first clinical sign of underlying myocardial ischemia, which results from an imbalance between oxygen supply and oxygen demand in the heart. This report describes the pharmacology of β-adrenoceptor antagonists as it relates to the treatment of angina. The β-adrenoceptor antagonists are widely used in long-term maintenance therapy to prevent acute ischemic episodes in patients with chronic stable angina. Beta-adrenoceptor antagonists competitively inhibit the bin...

  18. Beta-Blocking Agents and Electroconvulsive Therapy

    OpenAIRE

    Broek, Walter; Groenland, Theo; Kusuma, Ari; Birkenhäger, Tom; Pluijms, Esther; Bruijn, Jan; Mulder, Paul

    2007-01-01

    textabstractIn this review we want to summarize the results of the placebo-controlled randomized clinical trials with betablocking adrenergic agents during electroconvulsive therapy (ECT), and review the effect on seizure duration and cardiovascular variables. We searched for studies in the electronic databases Medline. Keywords combined in the search were: “beta-adrenergic blocking agents” and “electroconvulsive therapy”. The only limitation specified in the search was that the publications ...

  19. Tables of double beta decay data

    International Nuclear Information System (INIS)

    A compilation of experimental data on double beta decay is presented. The tables contain the most stringent known experimental limits or positive results of 2β transitions of 69 natural nuclides to ground and excited states of daughter nuclei for different channels (2β-; 2β+; εβ+; 2ε) and modes (0ν; 2ν; 0νM) of decay. (authors). 189 refs., 9 figs., 3 tabs

  20. JUNO and Neutrinoless Double Beta Decay

    OpenAIRE

    Ge, Shao-Feng; Rodejohann, Werner

    2015-01-01

    We study the impact of the precision determination of oscillation parameters in the JUNO experiment on half-life predictions for neutrinoless double beta decay. We show that the solar neutrino mixing angle can be measured by JUNO with below 1% uncertainty. This implies in particular that the minimal value of the effective mass in the inverted mass ordering will be known essentially without uncertainty. We demonstrate that this reduces the range of half-life predictions in order to test this v...

  1. Beta-Thalassaemia types in southern Sardinia.

    OpenAIRE

    Cao, A; Furbetta, M; Ximenes, A; Angius, A; Rosatelli, C; Tuveri, T; Scalas, M T; Falchi, A M; Maccioni, L; Melis, M A; R. Galanello

    1981-01-01

    In this study the prevalence of the different beta-thalassaemia types in southern Sardinia was investigated by cellulose acetate and agar gel electrophoresis or globin chain synthesis analysis on column chromatography or both in (1) all the patients (347) presenting with thalassaemia major or intermedia at our haematology service from 1976 to 1979, and (2) a group of 82 patients with transfusion-dependent thalassaemia major randomly chosen from 236 under our care. Apart from six subjects with...

  2. Risk adjusted equity valuation and accounting betas

    OpenAIRE

    Pope, P F; Wang, P.

    2000-01-01

    In this paper we develop a general equity valuation model where abnormal earnings, back value, the discount factor and interest rates evolve stochastically. Focusing on the dynamics of abnormal earnings, we demonstrate the back value, abnormal earnings, "other information" and two risk adjustment terms are sufficient for valuation when pricing kernel risk is attributable to a single market factor. The risk adjustment terms depend on accounting betas reflecting the covariances between abnormal...

  3. NEUTRINOLESS DOUBLE BETA DECAY: AN EXTREME CHALLENGE

    OpenAIRE

    Fernando Ferroni

    2013-01-01

    Neutrino-less Double Beta Decay is the only known way to possibly resolve the nature of neutrino mass. The chances to cover the mass region predicted by the inverted hierarchy require a step forward in detector capability. A possibility is to make use of scintillating bolometers. These devices shall have a great power in distinguishing signals from alfa particles from those induced by electrons. This feature might lead to an almost background-free experiment. Here the Lucifer concept will be ...

  4. Tensile creep of beta phase zircaloy-2

    International Nuclear Information System (INIS)

    The tensile creep and creep rupture properties of beta-phase zircaloy-2 are studied under vacuum in the temperature and stress range 1300-1550 K and 0.5-2 MN/m2. The new results are compared with previously reported uniaxial and biaxial data. A small but systematic difference is noted between the uniaxial and biaxial creep data and reasons for this discrepancy are discussed. (author)

  5. Precision mass measurements utilizing beta endpoints

    International Nuclear Information System (INIS)

    A technique for precise determination of beta endpoints with an intrinsic germanium detector has been developed. The energy calibration was derived from γ-ray photopeak measurements. This analysis procedure has been checked with a 27Si source produced in a (p,n) reaction on an 27Al target and subsequently applied to mass separated samples of 76Rb, 77Rb and 78Rb. Results indicate errors < 50 keV are obtainable. (orig.)

  6. Endopeptidase-Mediated Beta Lactam Tolerance

    OpenAIRE

    Dörr, Tobias; Davis, Brigid M.; Waldor, Matthew K.

    2015-01-01

    In many bacteria, inhibition of cell wall synthesis leads to cell death and lysis. The pathways and enzymes that mediate cell lysis after exposure to cell wall-acting antibiotics (e.g. beta lactams) are incompletely understood, but the activities of enzymes that degrade the cell wall (‘autolysins’) are thought to be critical. Here, we report that Vibrio cholerae, the cholera pathogen, is tolerant to antibiotics targeting cell wall synthesis. In response to a wide variety of cell wall- acting ...

  7. Nuclear Data Compilation for Beta Decay Isotope

    Science.gov (United States)

    Olmsted, Susan; Kelley, John; Sheu, Grace

    2015-10-01

    The Triangle Universities Nuclear Laboratory nuclear data group works with the Nuclear Structure and Decay Data network to compile and evaluate data for use in nuclear physics research and applied technologies. Teams of data evaluators search through the literature and examine the experimental values for various nuclear structure parameters. The present activity focused on reviewing all available literature to determine the most accurate half-life values for beta unstable isotopes in the A = 3-20 range. This analysis will eventually be folded into the ENSDF (Evaluated Nuclear Structure Data File). By surveying an accumulated compilation of reference articles, we gathered all of the experimental half-life values for the beta decay nuclides. We then used the Visual Averaging Library, a data evaluation software package, to find half-life values using several different averaging techniques. Ultimately, we found recommended half-life values for most of the mentioned beta decay isotopes, and updated web pages on the TUNL webpage to reflect these evaluations. To summarize, we compiled and evaluated literature reports on experimentally determined half-lives. Our findings have been used to update information given on the TUNL Nuclear Data Evaluation group website. This was an REU project with Triangle Universities Nuclear Laboratory.

  8. Thermal behaviour of beta-uranophane

    International Nuclear Information System (INIS)

    Beta-uranophane from Perus, SP, Brazil- has been heated progressively up to 1.3500C, and its thermal behaviour has been investigated thoroughly by several methods: thermo-gravimetry, differential thermal analysis, optical measurements, infra-red spectroscopy, and X-Ray diffraction. The mineral seems to be stable up to a temperature of 2000C, confirmed by the several experimental procedures. The differential thermal analysis gives a sharper point of transformation at 1650C, which should be ascribed to water evaporation (zeolitic water). The crystal structure of the mineral could be transformed into a random layer structure, due probably to loss of the structural water. This kind of crystal disorder induces, as a rule, in the X-ray powder diagrams, absences of the hkl reflections. This could explain the small number of observed lines in the powder photographs of the material heated above 2000C. A new phase transformation is reported in the temperature interval of 700 to 8000C. This transformation should be related to the beta-uranophane chemical breakdown into two or more new crystalline phases. The chemical composition of such products is discussed in the paper. As the temperature rises to a higher level, a phase transformation takes place between 1000 and 12000C and yet another one in the range of 1200 to 13500C. The latter transition could be ascribed to the formation of an alloy between the platinum holder and the breakdown products of beta-uranophane

  9. Beyond low beta-decay Q values

    Science.gov (United States)

    Mustonen, M. T.; Suhonen, J.

    2010-11-01

    Beta decays with low Q values can be utilized in the quest to determine the neutrino mass scale. This is being realized in two experiments, KATRIN and MARE, using tritium and 187Re, respectively. The beta-decay of 187Re had the lowest known Q value until 2005, when the beta decay of 115In to the first excited state of 115Sn was discovered in Gran Sasso underground laboratory. Last year two independent ion trap measurements confirmed that this decay breaks the former record by an order of magnitude. Our theoretical study on this tiny decay channel complemented the experimental effort by the JYFLTRAP group in Finland and HADES underground laboratory in Belgium. A significant discrepancy between the experimental and theoretical results was found. This might be explained by various atomic contributions known to grow larger as the Q value decreases. However, the traditional recipes for taking these effects into account break down on this new ultra-low Q value regime, providing new challenges for theorists on the borderline between nuclear and atomic physics.

  10. Beta decay properties from a statistical model

    International Nuclear Information System (INIS)

    The present work assumes that any intrinsic structure in the nuclei involved is not important. Only spin, parity, and energy are considered. Quantities such as half-life, average beta energy, or average gamma energy can be obtained by integrals over the beta strength function weighted by kinematic and other factors. The beta strength function is proportional to the level density multiplied by a reduced transition probability. Delayed neutron emission is calculated by assuming that the daughter is a compound nucleus which then statistically decays as in the Hauser-Feshbach approach. Using the ENDF/B-V fission product file which contains 877 nuclei, energy-dependent reduced transition probabilities were found for allowed 0+ → 1+ transitions (50 cases) and for other allowed transitions (over 600 cases), corresponding to log ft values of 4.3 and 5.6 respectively. No dependence on either transition energy or on mass was found. A reduced transition probability corresponding to log ft of 7.1 was used for first forbidden transitions. Some results are presented and discussed

  11. A low-noise beta-radiometer

    International Nuclear Information System (INIS)

    The two-channel detector for a low-noise (down to 0.06 sec-1) beta-radiometer for measuring the mass concentration of 90Sr in the environment after the chemical extraction of strontium by the oxalate-nitrate method was certified at the D.I. Mendeleev Institute of Metrology (certificate No. 137/93). A detector unit using two end-window self-quenching counters with thin input windows (8 μm thick and 60 mm in diameter) operating as a Geiger-Mueller counter and filled with a mixture of 90% helium (atomic gas) and 10% ethanol (organic molecules) can measure the beta-activity of two substrates concurrently. It is often used to detect the beta-radiation of 90Sr. This isotope produces particles with energies ranging from 180 to 1000 keV, and the detection efficiency is 50% at a level of 0.1 Bq after measuring for 20 min with an uncertainty of 25%

  12. Simulation in double-beta decay experiments

    International Nuclear Information System (INIS)

    A detailed understanding of background radiation sources is a key to interpretation and enhanced sensitivity of double-beta decay experiments. Improvement of several techniques will be discussed. An implementation of the EGS4 code was developed to improve the accuracy of detector simulations, in particular for a 100Mo double-beta decay experiment. The efficiency modification due to the angular dependence of the 539 keV - 590 keV gamma-ray coincidence was successfully determined. The success of the 100Mo effort led to the modeling of uranium-thorium backgrounds found in an electroformed copper shield built for a 76Ge experiment. The large copper mass increased our sensitivity to contaminants present in copper produced this way, and led to changes in our cryostat electroforming technique. The original goal was the determination of the 210Pb content of the 450 year old lead shield previously used in 71Ge two-neutrino double-beta decay measurements. The results pertaining to low background materials and fabrication techniques will also be discussed

  13. Neutrinoless beta-beta matrix element of 76Ge from spectroscopic data

    CERN Document Server

    Suhonen, J

    2008-01-01

    In this work we use the recently measured neutron pairing correlations in the 76Ge and 76Se nuclei as a guideline to adjust the single-particle energies in the 1p0f0g shell. The resulting BCS occupations reproduce the measured pairing data. The proton energies were inspected by using the odd-mass nuclei adjacent to 76Ge and 76Se as spectroscopic tools. The nuclear matrix element of the neutrinoless double beta (0-nu-beta-beta) decay of 76Ge is calculated in this fitted single-particle basis by using the proton-neutron quasiparticle random-phase approximation (pnQRPA) in a realistic model space and by adopting effective microscopic two-nucleon interactions. We include the nucleon-nucleon short-range correlations and other relevant corrections at the nucleon level. It is found that the resulting 0-nu-beta-beta matrix element is smaller than in the previous pnQRPA calculations, and closer to the recently reported shell-model results.

  14. Effects of calcium impurity on phase relationship, ionic conductivity and microstructure of Na$^{+}$-$\\beta/beta"$-alumina solid electrolyte

    Indian Academy of Sciences (India)

    SUNG-TAE LEE; DAE-HAN LEE; SANG-MIN LEE; SANG-SOO HAN; SANG-HYUNG LEE; SUNG-KI LIM

    2016-06-01

    Ca-doped Na$^{+}$-$\\beta/beta"$-alumina was synthesized using a solid-state reaction. The changes in the properties of Na$^{+}$-$\\beta/beta"$-alumina resulting from the presence of Ca impurity were studied. Ca (0–5 wt%) was added to the respective samples, which were then sintered. The specimens were characterized using X-ray diffraction, scanningelectron microscopy, densimetry and impedance analysis. In the sintered specimens, the $\\beta"$-alumina phase fraction decreased as Ca content increased, whereas the relative sintered density increased. The surface morphology of Cadoped Na$^{+}$-$\\beta/beta"$-alumina specimens showed a Ca-rich layer, which was the main cause of increase in the specificresistance.

  15. Beta-blockers and heart failure.

    Science.gov (United States)

    Cruickshank, John M

    2010-01-01

    The life-time risk of developing HF is about 20% (40% if hypertension present). With increasing longevity in the developed world the burden of HF (hospitalisation) is set to increase over the next 10-20 years. CAD and hypertension are the two main causes of HF; CAD (and obesity) in the case of systolic HF and hypertension in the case of diastolic HF (mainly in the elderly). BB have become the corner-stone (alongside ACE-inhibitors) in the treatment of systolic HF. Bisoprolol, metoprolol and carvedilol (on an ACE-inhibitor background) have reduced all-cause death by 34-5%. The presence of intrinsic sympathomemetic activity (xamoterol, bucindolol, nebivolol) diminishes efficacy in the treatment of systolic HF. First-line bisoprolol has proved "non-inferior" to first-line enalapril in reducing all-cause death and is probably superior in reducing sudden death. The main mode of action of BB in treating systolic HF is inhibition of chronic beta-1 stimulation-induced myocardial apoptosis/necrosis/inflammation. The combination of pure beta-1 blockade (low-dose bisoprolol) and pure beta-2 blockade (clenbuterol) may prove invaluable in the treatment of end-stage systolic HF (thus avoiding cardiac transplantation). The appropriate treatment of diastolic HF has yet to be determined. Beta-blockade is effective in the prevention of HF i) in the post-MI period and ii) as first-line agents in the treatment of young/middle-aged hypertension and as second-line agents (to first-line diuretics) in the treatment of elderly systolic hypertension. BB are highly effective in reversing LVH in young/middle-aged hypertensives (LVH pre-disposes to HF in young/middle-aged hypertension) and are (bisoprolol) at least as good as ACE-inhibitors. Choice of BB is important as benefit is not a class-effect. ISA (xamoterol, bucindolol, nebivolol) markedly diminishes efficacy. The choice is between bisoprolol, metoprolol succinate and carvedilol for optimal efficacy. Adverse reactions are associated

  16. A Novel Dimeric Inhibitor Targeting Beta2GPI in Beta2GPI/Antibody Complexes Implicated in Antiphospholipid Syndrome

    Energy Technology Data Exchange (ETDEWEB)

    A Kolyada; C Lee; A De Biasio; N Beglova

    2011-12-31

    {beta}2GPI is a major antigen for autoantibodies associated with antiphospholipid syndrome (APS), an autoimmune disease characterized by thrombosis and recurrent pregnancy loss. Only the dimeric form of {beta}2GPI generated by anti-{beta}2GPI antibodies is pathologically important, in contrast to monomeric {beta}2GPI which is abundant in plasma. We created a dimeric inhibitor, A1-A1, to selectively target {beta}2GPI in {beta}2GPI/antibody complexes. To make this inhibitor, we isolated the first ligand-binding module from ApoER2 (A1) and connected two A1 modules with a flexible linker. A1-A1 interferes with two pathologically important interactions in APS, the binding of {beta}2GPI/antibody complexes with anionic phospholipids and ApoER2. We compared the efficiency of A1-A1 to monomeric A1 for inhibition of the binding of {beta}2GPI/antibody complexes to anionic phospholipids. We tested the inhibition of {beta}2GPI present in human serum, {beta}2GPI purified from human plasma and the individual domain V of {beta}2GPI. We demonstrated that when {beta}2GPI/antibody complexes are formed, A1-A1 is much more effective than A1 in inhibition of the binding of {beta}2GPI to cardiolipin, regardless of the source of {beta}2GPI. Similarly, A1-A1 strongly inhibits the binding of dimerized domain V of {beta}2GPI to cardiolipin compared to the monomeric A1 inhibitor. In the absence of anti-{beta}2GPI antibodies, both A1-A1 and A1 only weakly inhibit the binding of pathologically inactive monomeric {beta}2GPI to cardiolipin. Our results suggest that the approach of using a dimeric inhibitor to block {beta}2GPI in the pathological multivalent {beta}2GPI/antibody complexes holds significant promise. The novel inhibitor A1-A1 may be a starting point in the development of an effective therapeutic for antiphospholipid syndrome.

  17. Search for beta plus/EC double beta decay of 120Te

    CERN Document Server

    Andreotti, E; Avignone, F T; Balata, M; Bandac, I; Barucci, M; Beeman, J W; Bellini, F; Brofferio, C; Bryant, A; Bucci, C; Canonica, L; Capelli, S; Carbone, L; Carrettoni, M; Clemenza, M; Cremonesi, O; Creswick, R J; Di Domizio, S; Dolinski, M J; Ejzak, L; Faccini, R; Farach, H A; Ferri, E; Fiorini, E; Foggetta, L; Giachero, A; Gironi, L; Giuliani, A; Gorla, P; Guardincerri, E; Haller, T D Gutierrez E E; Kazkaz, K; Kraft, S; Kogler, L; Maiano, C; Maruyama, R H; Martinez, C; Martinez, M; Mizouni, L; Newman, S; Nisi, S; Nones, C; Norman, E B; Nucciotti, A; Orio, F; Pallavicini, M; Palmieri, V; Pattavina, L; Pavan, M; Pedretti, M; Pessina, G; Pirro, S; Previtali, E; Risegari, L; Rosenfeld, C; Rusconi, C; Salvioni, C; Sangiorgio, S; Schaeffer, D; Scielzo, N D; Sisti, M; Smith, A R; Tomei, C; Ventura, G; Vignati, M

    2010-01-01

    We present a search for beta plus/EC double beta decay of 120Te performed with the CUORICINO experiment, an array of TeO2 cryogenic bolometers. After collecting 0.0573 kg y of 120Te, we see no evidence of a signal and therefore set the following limits on the half-life: T1/2 (0nu) > 1.9 10^{21} y at 90% C.L. for the 0 neutrino mode and T1/2 (2nu) > 7.6 10^{19} y at 90% C.L. for the two neutrino mode. These results improve the existing limits by almost three orders of magnitude (four in the case of 0 neutrino mode). Moreover the limit on zero neutrino beta plus/EC represents the most stringent half-life limit ever achieved for this decay mode for any isotope.

  18. Evaluation of thrombogenicity of beta-propiolactone/ultraviolet (beta-PL/UV) treated PPSB in chimpanzees

    Energy Technology Data Exchange (ETDEWEB)

    Kotitschke, R.; Stephan, W.; Prince, A.M.; Brotman, B.

    1983-05-01

    The thrombogenicity of beta-PL/UV-treated PPSB (factor IX concentrate) was evaluated in chimpanzees. PPSB isolated from beta-propiolactone-treated and UV-irradiated plasma was injected into chimpanzees at a dose of approximately 100 units/kg body weight. An FDA licensed PPSB preparation served as the negative control, and a preparation containing activated as well as precursor clotting factors served as the positive control. 15 minutes, 1 h, 4 h, and 24 h after the PPSB application the following parameters were determined in the chimpanzee blood: factors II, VII, IX, X, VIII, fibrinogen, AT III, thrombin coagulase, Quick value, APTT and platelet count. Neither the untreated control preparation, nor the PPSB isolated from beta-propiolactone-treated and UV-irradiated plasma, showed signs of thrombogenicity in the chimpanzee model. The positive control indicated that the chimpanzee is a suitable model for the thrombogenicity testing of activated clotting factors.

  19. Beta-decay rate and beta-delayed neutron emission probability of improved gross theory

    Science.gov (United States)

    Koura, Hiroyuki

    2014-09-01

    A theoretical study has been carried out on beta-decay rate and beta-delayed neutron emission probability. The gross theory of the beta decay is based on an idea of the sum rule of the beta-decay strength function, and has succeeded in describing beta-decay half-lives of nuclei overall nuclear mass region. The gross theory includes not only the allowed transition as the Fermi and the Gamow-Teller, but also the first-forbidden transition. In this work, some improvements are introduced as the nuclear shell correction on nuclear level densities and the nuclear deformation for nuclear strength functions, those effects were not included in the original gross theory. The shell energy and the nuclear deformation for unmeasured nuclei are adopted from the KTUY nuclear mass formula, which is based on the spherical-basis method. Considering the properties of the integrated Fermi function, we can roughly categorized energy region of excited-state of a daughter nucleus into three regions: a highly-excited energy region, which fully affect a delayed neutron probability, a middle energy region, which is estimated to contribute the decay heat, and a region neighboring the ground-state, which determines the beta-decay rate. Some results will be given in the presentation. A theoretical study has been carried out on beta-decay rate and beta-delayed neutron emission probability. The gross theory of the beta decay is based on an idea of the sum rule of the beta-decay strength function, and has succeeded in describing beta-decay half-lives of nuclei overall nuclear mass region. The gross theory includes not only the allowed transition as the Fermi and the Gamow-Teller, but also the first-forbidden transition. In this work, some improvements are introduced as the nuclear shell correction on nuclear level densities and the nuclear deformation for nuclear strength functions, those effects were not included in the original gross theory. The shell energy and the nuclear deformation for

  20. The beta strength function structure in \\beta + decay of lutecium, thulium and cesium isotopes

    CERN Document Server

    Alkhazov, G D; Naumov, Yu V; Orlov, S Yu; Vitman, V D

    1981-01-01

    The spectra of total gamma -absorption in the decays of some lutetium, thulium and cesium isotopes have been measured. The probabilities for level population in the decay of the isotopes have been determined. The deduced beta strength functions reveal pronounced structure. Calculations of the strength functions using the Saxon-Woods potential and the residual Gamow-Teller interaction are presented. It is shown that in beta /sup +/ decay of light thulium and cesium isotopes the strength function comprises more than 70% of the Gamow-Teller excitations with mu /sub tau /=+1. This result is the first direct observation of the Gamov-Teller resonance in beta /sup +/ decay of nuclei with T/sub z/>0. (21 refs).

  1. In vitro proliferation of adult human beta-cells.

    Directory of Open Access Journals (Sweden)

    Sabine Rutti

    Full Text Available A decrease in functional beta-cell mass is a key feature of type 2 diabetes. Glucagon-like peptide 1 (GLP-1 analogues induce proliferation of rodent beta-cells. However, the proliferative capacity of human beta-cells and its modulation by GLP-1 analogues remain to be fully investigated. We therefore sought to quantify adult human beta-cell proliferation in vitro and whether this is affected by the GLP-1 analogue liraglutide.Human islets from 7 adult cadaveric organ donors were dispersed into single cells. Beta-cells were purified by FACS. Non-sorted cells and the beta-cell enriched ("beta-cells" population were plated on extracellular matrix from rat (804G and human bladder carcinoma cells (HTB9 or bovine corneal endothelial ECM (BCEC. Cells were maintained in culture+/-liraglutide for 4 days in the presence of BrdU.Rare human beta-cell proliferation could be observed either in the purified beta-cell population (0.051±0.020%; 22 beta-cells proliferating out of 84'283 beta-cells counted or in the non-sorted cell population (0.055±0.011%; 104 proliferating beta-cells out of 232'826 beta-cells counted, independently of the matrix or the culture conditions. Liraglutide increased human beta-cell proliferation on BCEC in the non-sorted cell population (0.082±0.034% proliferating beta-cells vs. 0.017±0.008% in control, p<0.05.These results indicate that adult human beta-cell proliferation can occur in vitro but remains an extremely rare event with these donors and particular culture conditions. Liraglutide increases beta-cell proliferation only in the non-sorted cell population and only on BCEC. However, it cannot be excluded that human beta-cells may proliferate to a greater extent in situ in response to natural stimuli.

  2. Thymosin beta 4 and thymosin beta 10 expression in hepatocellular carcinoma

    Directory of Open Access Journals (Sweden)

    W. Theunissen

    2014-03-01

    Full Text Available Thymosin beta 4 (Tβ4 and thymosin beta 10 (Tβ10 are two members of the beta-thymosin family involved in many cellular processes such as cellular motility, angiogenesis, inflammation, cell survival and wound healing. Recently, a role for beta-thymosins has been proposed in the process of carcinogenesis as both peptides were detected in several types of cancer. The aim of the present study was to investigate the expression pattern of Tβ4 and Tβ10 in hepatocellular carcinoma (HCC. To this end, the expression pattern of both peptides was analyzed in liver samples obtained from 23 subjects diagnosed with HCC. Routinely formalin-fixed and paraffin-embedded liver samples were immunostained by indirect immunohistochemistry with polyclonal antibodies to Tβ4 and Tβ10. Immunoreactivity for Tβ4 and Tβ10 was detected in the liver parenchyma of the surrounding tumor area. Both peptides showed an increase in granular reactivity from the periportal to the periterminal hepatocytes. Regarding HCC, Tβ4 reactivity was detected in 7/23 cases (30% and Tβ10 reactivity in 22/23 (97% cases analyzed, adding HCC to human cancers that express these beta-thymosins. Intriguing finding was seen looking at the reactivity of both peptides in tumor cells infiltrating the surrounding liver. Where Tβ10 showed a strong homogeneous expression, was Tβ4 completely absent in cells undergoing stromal invasion. The current study shows expression of both beta-thymosins in HCC with marked differences in their degree of expression and frequency of immunoreactivity. The higher incidence of Tβ10 expression and its higher reactivity in tumor cells involved in stromal invasion indicate a possible major role for Tβ10 in HCC progression.

  3. BETA. A code for {beta}{sub eff} measurement and analysis

    Energy Technology Data Exchange (ETDEWEB)

    Kato, Yuichi; Okajima, Shigeaki; Sakurai, Takeshi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1999-03-01

    The code BETA has been developed to calculate the following reactor physics parameters which are used for the {beta}{sub eff} measurement and analysis; Diven factor, Spatial correction factor (g-factor) for neutron correlation experiment, Adjoint weighted g-factor, Fission rate integrated in whole reactor and Adjoint weighted fission rate integrated in whole reactor: The code also calculates the effective delayed neutron fraction with different evaluated delayed neutron data. These parameters are calculated with using the forward and adjoint fluxes given by SLAROM, POPLARS or TWOTRAN-II. This report describes the input data and job control statements instructions, file requirements and sample input output data. (author)

  4. Sizeable beta-strength in 31Ar (beta 3p) decay

    DEFF Research Database (Denmark)

    T. Koldste, G.; Blank, B.; J. G. Borge, M.;

    2014-01-01

    We present for the first time precise spectroscopic information on the recently discovered decay mode beta-delayed 3p-emission. The detection of the 3p events gives an increased sensitivity to the high energy part of the Gamow-Teller strength distribution from the decay of 31Ar revealing that as...... much as 30% of the strength resides in the beta-3p decay mode. A simplified description of how the main decay modes evolve as the excitation energy increases in 31Cl is provided....

  5. Sensitive behavior of 2{nu}{beta}{beta}-decay amplitude within QRPA and broken SU(4) symmetry in nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Rodin, Vadim A. [Institut fuer Theoretische Physik der Universitaet Tuebingen, Auf der Morgenstelle 14, D-72076 Tuebingen (Germany)]. E-mail: vadim.rodin@uni-tuebingen.de; Urin, Michael H. [Department of Theoretical Nuclear Physics, Moscow State Engineering and Physics Institute, 115409 Moscow (Russian Federation); Kernfysisch Versneller Institute, NL-9747AA Groningen (Netherlands); Faessler, Amand [Institut fuer Theoretische Physik der Universitaet Tuebingen, Auf der Morgenstelle 14, D-72076 Tuebingen (Germany)

    2005-01-24

    Making use of an identity transformation independent of a nuclear model, we represent the 2{nu}{beta}{beta}-amplitude as a sum of two terms. One term accounts for most of the sensitivity of the original 2{nu}{beta}{beta}-amplitude to gpp' for realistic gpp'{approx}1 (with gpp' being the ratio of the triplet and singlet p-p interaction strengths) and is determined by a specific energy-weighted sum rule. The sum rule depends only on the particle-particle residual interaction (being linear function of gpp' in the QRPA) and passes through zero at the point gpp'=1 where the Wigner SU(4) symmetry is restored in the p-p sector of the Hamiltonian. The second term in the decomposition of the 2{nu}{beta}{beta}-amplitude is demonstrated within the QRPA to be a much smoother function for the realistic values of gpp' than the original 2{nu}{beta}{beta}-amplitude. This term is mainly determined by the intensity of the spin-orbit interaction of the nuclear mean field. Thus, the analysis of the present work reveals the reasons for the sensitivity of the 2{nu}{beta}{beta}-amplitude to different components of the nuclear Hamiltonian and thereby can help in constraining nuclear model uncertainties in calculations of the amplitude.

  6. The effects of beta-carotene and vitamin E on erythrocytes lipid peroxidation in beta-thalassemia patients

    Directory of Open Access Journals (Sweden)

    Soleiman Mahjoub

    2007-12-01

    Full Text Available BACKGROUND: Thalassemia is the most common hereditary disease in the world. Thalassemic erythrocytes are exposed to higher oxidative stress and lipid peroxidation. The aim of this study was to investigate the effects of beta-carotene and vitamin E on erythrocytes lipid peroxidation in beta-thalassemia patients.
    METHODS: A prospective double-blind, placebo-controlled study of the effect of beta-carotene and vitamin E on lipid peroxidation in erythrocytes membranes was performed on 120 beta-thalassemia major patients in four groups. The patients were supplemented for 4 weeks as follows: group 1 with beta-carotene (13 mg/day, group 2 with vitamin E (550 mg/day, group 3 with beta-carotene plus vitamin E and group 4 with placebo. We prepared all capsules for 4 roups in the same shape and color. Measurements of serum beta-carotene and vitamin E were performed by high performance
    liquid chromatography. After preparation of ghost cells from blood specimens, malondialdehyde (MDA was determined as index of lipid peroxidation in erythrocytes membranes before and after treatment. RESULTS: The levels of serum beta-carotene and vitamin E were significantly lower and MDA concentrations in erythrocytes membranes were significantly higher in beta-thalassemia patients compared to controls (P<0.001. In groups that treated with vitamin supplements for 4-weeks, lipid peroxidation rates were significantly reduced after treatment (P<0.001, but in placebo group there was not significant difference (P>0.05.
    CONCLUSIONS: Our findings provide evidence that an oral treatment with beta-carotene and vitamin E can significantly reduce lipid peroxidation of erythrocytes membranes and could be useful in management of beta-thalassemia major patients. KEYWORDS: Beta-thalassemia major, beta-carotene, vitamin E, malondialdehyde, lipid peroxidation.

  7. Coexistence of beta 1- and beta 2-adrenoceptors in the rabbit heart: quantitative analysis of the regional distribution by (-)-3H-dihydroalprenolol binding

    International Nuclear Information System (INIS)

    We determined the amount of beta 1- and beta 2-adrenoceptors in right and left atria and ventricles of rabbits. For this purpose inhibition of specific (-)-3H-dihydroalprenolol [(-)-3H-DHA] binding (5 nM) by beta 1-selective (practolol, metoprolol) and beta 2-selective (zinterol, IPS 339) adrenergic drugs was determined and analyzed by pseudo-Scatchard (Hofstee) plots. For both atria, inhibition of binding by the four selective beta-adrenergic drugs resulted in non-linear Hofstee plots, suggesting the coexistence of both beta-adrenoceptor subtypes. From these plots we calculated a beta 1:beta 2-adrenoceptor ratio of 72:28 for the right atrium and of 82:18 for the left. In contrast, only a very small amount of beta 2-adrenoceptors (approximately 5-7% of the total beta-adrenoceptor population) could be detected in the ventricles. For comparison we analyzed the inhibition of specific (-)-3H-DHA binding in tissues with homogeneous population of beta-adrenoceptors (beta 1:guinea pig left ventricle; beta 2: cerebellum of mature rats). For both tissues the four selective beta-adrenergic drugs showed linear Hofstee plots, demonstrating that in tissues with homogeneous beta-receptor population interaction of each drug with the receptor followed simple mass-action kinetics. We conclude that beta 1- and beta 2-adrenoceptors coexist in rabbit atria while the ventricles are predominantly endowed the beta 1-adrenoceptors

  8. Coexistence of beta 1- and beta 2-adrenoceptors in the rabbit heart: quantitative analysis of the regional distribution by (-)-/sup 3/H-dihydroalprenolol binding

    Energy Technology Data Exchange (ETDEWEB)

    Brodde, O.E.; Leifert, F.J.; Krehl, H.J.

    1982-01-01

    We determined the amount of beta 1- and beta 2-adrenoceptors in right and left atria and ventricles of rabbits. For this purpose inhibition of specific (-)-/sup 3/H-dihydroalprenolol ((-)-/sup 3/H-DHA) binding (5 nM) by beta 1-selective (practolol, metoprolol) and beta 2-selective (zinterol, IPS 339) adrenergic drugs was determined and analyzed by pseudo-Scatchard (Hofstee) plots. For both atria, inhibition of binding by the four selective beta-adrenergic drugs resulted in non-linear Hofstee plots, suggesting the coexistence of both beta-adrenoceptor subtypes. From these plots we calculated a beta 1:beta 2-adrenoceptor ratio of 72:28 for the right atrium and of 82:18 for the left. In contrast, only a very small amount of beta 2-adrenoceptors (approximately 5-7% of the total beta-adrenoceptor population) could be detected in the ventricles. For comparison we analyzed the inhibition of specific (-)-/sup 3/H-DHA binding in tissues with homogeneous population of beta-adrenoceptors (beta 1:guinea pig left ventricle; beta 2: cerebellum of mature rats). For both tissues the four selective beta-adrenergic drugs showed linear Hofstee plots, demonstrating that in tissues with homogeneous beta-receptor population interaction of each drug with the receptor followed simple mass-action kinetics. We conclude that beta 1- and beta 2-adrenoceptors coexist in rabbit atria while the ventricles are predominantly endowed the beta 1-adrenoceptors.

  9. Dopaminergic and beta-adrenergic effects on gastric antral motility

    DEFF Research Database (Denmark)

    Bech, K; Hovendal, C P; Gottrup, F;

    1984-01-01

    bethanechol or pentagastrin inducing motor activity patterns as in the phase III of the MMC and the digestive state respectively. The stimulated antral motility was dose-dependently inhibited by dopamine. The effect was significantly blocked by specifically acting dopaminergic blockers, while alpha- and beta......-adrenergic blockers were without any significant effects. Dose-response experiments with bethanechol and dopamine showed inhibition of a non-competitive type. Isoprenaline was used alone and in conjunction with selective blockade of beta 1- and beta 2-receptors during infusion of bethanechol which induces a pattern...... similar to phase III in the migrating myoelectric complex. The stimulated antral motility was dose-dependently inhibited by isoprenaline. The effect could be significantly blocked by propranolol (beta 1 + beta 2-adrenoceptor blocker) and by using in conjunction the beta 1-adrenoceptor blocker practolol...

  10. Fracture risk in perimenopausal women treated with beta-blockers

    DEFF Research Database (Denmark)

    Rejnmark, Lars; Vestergaard, Peter; Kassem, Moustapha;

    2004-01-01

    beta2-Adrenergic receptors have been identified on human osteoblastic and osteoclastic cells, raising the question of a sympathetic regulation of bone metabolism. We investigated effects of treatment with beta-adrenergic receptor antagonists (beta-blockers) on bone turnover, bone mineral density...... (BMD), and fracture risk. Within the Danish Osteoporosis Prevention Study (DOPS) a population based, comprehensive cohort study of 2016 perimenopausal women, associations between treatment with beta-blockers and bone turnover and BMD were assessed in a cross-sectional design at the start of study....... Moreover, in a nested case-control design, fracture risk during the subsequent 5 years was assessed in relation to treatment with beta-blockers at baseline. Multiple regression- and logistic regression-analyses were performed. Treatment with beta-blockers was associated with a threefold increased fracture...

  11. Distribution of beta-amyloid in the canine brain.

    Science.gov (United States)

    Hou, Y; White, R G; Bobik, M; Marks, J S; Russell, M J

    1997-03-01

    The distribution of amyloid-beta protein (A beta) in the canine brain was demonstrated by immunochemistry on serially sectioned tissues from 10 aged mixed breed dogs. Summation of quantitative data and relegation to anatomical sites for the 10 dogs showed A beta to be widely distributed in the cortex and hippocampus while completely absent in the brain stem and cerebellum. The highest density of A beta was in the dentate gyrus of the hippocampus. Cortical areas exhibiting the greatest A beta deposition were the posterior and medial suprasylvius gyrus and the proreus gyrus of the frontal lobe. Unlike humans the canine entorhinal cortex, amygdala, basal ganglia and olfactory bulbs were rarely affected. This suggested that the highly developed olfactory pathways of the canine are generally spared from A beta deposition. PMID:9141082

  12. Double-beta decay in gauge theories

    International Nuclear Information System (INIS)

    The double-beta decay in gauge theories is considered. The review of the 76Ge, 82Se, 96Zr, 100Cd, 128Te, 130Te, 136Xe and 150Nd experimental nuclear targets is presented. The mechanism of the Majorana intermediate neutrino is considered. The R-parity of the violation of the contribution to the 0νββ decay is studied. The effective nucleon currents in dependence on the momentum are discussed. The extraction of the lepton number, violating the double-β decay parameters is presented

  13. Double-beta decay in deformed nuclei

    International Nuclear Information System (INIS)

    A brief review of theoretical results for the double-beta decay and the double-electron capture in heavy deformed nuclei is presented. The ββ half life of 160Gd is evaluated using an extended version of the pseudo SU(3) model. While the 2ν mode is forbidden when the most probable occupations are considered, states with different occupation numbers can be mixed through the pairing interaction. The amount of this mixing is calculated using perturbation theory. The possibility of observing the ββ decay in 160Gd is discussed for both the 2ν and 0ν modes. (author)

  14. Intracranial Extramedullary Hematopoiesis in Beta-Thalassemia

    International Nuclear Information System (INIS)

    Extramedullary hematopoiesis (EMH) represents tumor-like proliferation of hemopoietic tissue which complicates chronic hemoglobinopathy. Intracranial EMH is an extremely rare occurrence. Magnetic resonance imaging (MRI) offers a precise diagnosis. It is essential to distinguish EMH from other extradural central nervous system tumors, because treatment and prognosis are totally different. Herein, we report the imaging findings of beta-thalassemia in a 13-year-old boy complaining of weakness of left side of the body and gait disturbance; CT and MRI revealed an extradural mass in the right temporoparietal region.

  15. Neutrinoless double beta decay search with SNO+

    OpenAIRE

    Lozza V.

    2014-01-01

    The SNO+ experiment is the follow up of SNO. The detector is located 2 km underground in the Vale Canada Ltd.’s Creighton Mine near Sudbury, Ontario, Canada. The active volume of the detector consists of 780 tonnes of Linear Alkyl Benzene (LAB) in an acrylic vessel of 12 m diameter, surrounded by about 9500 PMTs. The main goal of the SNO+ experiment is the search for neutrinoless double beta decay of 130Te. With an initial loading of 0.3% of natural tellurium (nearly 800 kg of 130Te), it is e...

  16. The high sensitivity double beta spectrometer TGV

    Science.gov (United States)

    Briancon, Ch.; Brudanin, V. B.; Egorov, V. G.; Janout, Z.; Koníček, J.; Kovalík, A.; Kovalenko, V. E.; Kubašta, J.; Pospíšil, S.; Revenko, A. V.; Rukhadze, N. I.; Salamatin, A. V.; Sandukovsky, V. G.; Štekl, I.; Timkin, V. V.; Tsupko-Sitnikov, V. V.; Vorobel, V.; Vylov, Ts.

    1996-02-01

    A high sensitivity double beta spectrometer TGV (Telescope Germanium Vertical) has been developed. It is based on 16 HPGe detectors of volume 1200 × 6 mm 3 each in the same cryostat. The TGV spectrometer was proposed for the study of ultrarare nuclear processes (e.g. 2νββ, 0νββ, 2νEC/EC). Details of the TGV spectrometer construction are described, the principles of background suppression, the results of Monte Carlo simulations and the results of test background measurements (in Dubna and Modane underground laboratory) are provided.

  17. The high sensitivity double beta spectrometer TGV

    International Nuclear Information System (INIS)

    A high sensitivity double beta spectrometer TGV (Telescope Germanium Vertical) has been developed. It is based on 16 HPGe detectors of volume 1200 x 6 mm3 each in the same cryostat. The TGV spectrometer was proposed for the study of ultrarare nuclear processes (e.g. 2νββ, 0νββ, 2νEC/EC). Details of the TGV spectrometer construction are described, the principles of background suppression, the results of Monte Carlo simulations and the results of test background measurements (in Dubna and Modane underground laboratory) are provided. (orig.)

  18. MHD stable high beta spheromak equilibrium

    International Nuclear Information System (INIS)

    Recent observations of a pressure driven mode in CTX indicate that its performance is being limited by the low beta stability requirements typical of conventional spheromak designs. Improved designs with higher beat limits therefore have the potential to dramatically increase the temperature and lifetime of CTX and other spheromak experiments. This paper describes the results of an optimization study examining radically different geometries, but all with minimum energy current profiles which can easily be created experimentally and should be automatically stable to all ideal and resistive current drive modes. 2 refs., 3 figs

  19. NEUTRINOLESS DOUBLE BETA DECAY: AN EXTREME CHALLENGE

    Directory of Open Access Journals (Sweden)

    Fernando Ferroni

    2013-12-01

    Full Text Available Neutrino-less Double Beta Decay is the only known way to possibly resolve the nature of neutrino mass. The chances to cover the mass region predicted by the inverted hierarchy require a step forward in detector capability. A possibility is to make use of scintillating bolometers. These devices shall have a great power in distinguishing signals from alfa particles from those induced by electrons. This feature might lead to an almost background-free experiment. Here the Lucifer concept will be introduced and the prospects related to this project will be discussed.

  20. Perioperative Beta Blockade - A Case Report

    Directory of Open Access Journals (Sweden)

    Sunitha K. Zachariah

    2009-10-01

    Full Text Available Continuation of antihypertensives preoperatively and their influence on intraoperative hemodynamics is a big concern among anesthesiologists. The Peri Operative Ischaemia Study Evaluation (POISE trial showed a significant reduction of myocardial infarction, need for coronary revascularization and the incidence of atrial fibrillation with metoprolol started 2-4 hours prior to surgery but a significant increase in total mortality and clinically significant hypotension and bradycardia. This is a case report of intraoperative severe bradycardia in a young patient on recently started beta blocker.

  1. Mass spectrometric study of fluorinated. beta. -diketones

    Energy Technology Data Exchange (ETDEWEB)

    Lozinskii, M.O.; Fialkov, Yu.A.; Khomenko, V.S.; Krasovskaya, L.I.; Rasshinina, T.A.; Berenblit, V.V.

    1985-09-01

    Mass spectrometry has been applied in an investigation of fluorinated ..beta..-diketones and the decomposition of these compounds under electron impact. It has been shown that there is a possibility that intramolecular hydrogen bonds of the -H...O double bond and -H...F- types may exist in the fluorinated delta-diketones and the products of their decomposition in the gas phase, these bonds playing an important role in the mechanism fragmentation. The formation of cyclic structures in this process is postulated.

  2. Improved Synthesis Of Potassium Beta' '-Alumina

    Science.gov (United States)

    Williams, Roger M.; Jeffries-Nakamura, Barbara; Ryan, Margaret A.; O'Connor, Dennis E.; Kisor, Adam; Underwood, Mark

    1996-01-01

    Improved formulations of precursor materials synthesize nearly-phase-pure potassium beta' '-alumina solid electrolyte (K-BASE) powder. Materials are microhomogeneous powders (or, alternatively, gels) containing K(+,) Mg(2+), and Al(3+). K-BASE powder produced used in potassium-working-fluid alkali-metal thermal-to-electric conversion (K-AMTEC), in which heat-input and heat-rejection temperatures lower than sodium-working-fluid AMTEC (Na-AMTEC). Additional potential use lies in purification of pottassium by removal of sodium and calcium.

  3. The Beta-MANOVA Ensemble with General Covariance

    OpenAIRE

    Dubbs, Alexander; Edelman, Alan

    2013-01-01

    We find the joint generalized singular value distribution and largest generalized singular value distributions of the $\\beta$-MANOVA ensemble with positive diagonal covariance, which is general. This has been done for the continuous $\\beta > 0$ case for identity covariance (in eigenvalue form), and by setting the covariance to $I$ in our model we get another version. For the diagonal covariance case, it has only been done for $\\beta = 1,2,4$ cases (real, complex, and quaternion matrix entries...

  4. Reversion reactions of beta-galactosidase (Escherichia coli).

    Science.gov (United States)

    Huber, R E; Hurlburt, K L

    1986-04-01

    The reversion reactions of beta-galactosidase (Escherichia coli) produced beta-galactosyl-galactoses and beta-galactosyl-glucoses. About 10 beta-galactosyl-galactose and 10 beta-galactosyl-glucose gas-liquid chromatographic peaks were detected and it is thus very likely that every possible isomer of beta-galactosyl-galactose and beta-galactosyl-glucose was formed by the reversion reactions (taking into account both anomers for each isomer). The presence of lactose and allolactose among the beta-galactosyl-glucoses was confirmed with standards. An important finding relating to the role of allolactose as an inducer of the lac operon was that allolactose (beta-D-galactosyl-(1----6)-D-glucose) was the only disaccharide formed initially, and at equilibrium it was present in the largest amount (50%). Obviously the enzyme is specific in its ability to form allolactose, and allolactose is the most stable beta-galactosyl-glucose, both important inducer properties. The equilibrium constant (concentration of disaccharides divided by the concentration of reactants at equilibrium) of the reaction was about 9.5 mM-1. This is the first report of an equilibrium constant for the beta-galactosidase reaction. Of mechanistic significance is the fact that only three compounds were able to replace D-galactose as a reversion reactant. Two of these (L-arabinose and D-fucose) had alterations at carbon 6. The 6 position, therefore, is not essential for reactivity. The third compound was D-galactal. Any other sugars tested (even with very minor changes relative to D-galactose) did not react. Of special consequence is the 2 position. The results strongly suggest that there has to be either an equatorial hydroxyl at the 2 position of a sugar or a special reactivity (as with D-galactal) in order for the enzyme to catalyze the beta-galactosidase reaction. PMID:3083779

  5. Proceedings of the Department of Energy workshop on beta measurements

    Energy Technology Data Exchange (ETDEWEB)

    Swinth, K.L.; Vallario, E.J.

    1987-09-01

    Participants discussed current practices, efforts to upgrade the quality of beta measurements, and initiatives necessary to improve the measurement and control of beta doses. This proceedings includes papers presented at the workshop, transcripts of panel and open discussions, and documentation of question and answer sessions. The information exchange resulting from this meeting is expected to provide a clearer focus on the problems of beta measurements.

  6. Bootstrap transition to high beta equilibrium in helical system

    International Nuclear Information System (INIS)

    It is shown theoretically and computationally that helical magnetic field, produced by continuous winding helical coils and without the toroidal coil, can sustain MHD stable high beta plasma. Pressure driven toroidal current (bootstrap current) cancels the external magnetic field and reduces the MHD potential energy, depending on the plasma beta values. Ramp-up of heating power input induces bootstrap transition to higher beta plasmas with flat-top pressure profiles. Helical pitch parameter dependence of MHD stability is analyzed. (author)

  7. Proceedings of the Department of Energy workshop on beta measurements

    International Nuclear Information System (INIS)

    Participants discussed current practices, efforts to upgrade the quality of beta measurements, and initiatives necessary to improve the measurement and control of beta doses. This proceedings includes papers presented at the workshop, transcripts of panel and open discussions, and documentation of question and answer sessions. The information exchange resulting from this meeting is expected to provide a clearer focus on the problems of beta measurements

  8. Cyclic beta-glucans of members of the family Rhizobiaceae.

    OpenAIRE

    Breedveld, M. W.; Miller, K. J.

    1994-01-01

    Cyclic beta-glucans are low-molecular-weight cell surface carbohydrates that are found almost exclusively in bacteria of the Rhizobiaceae family. These glucans are major cellular constituents, and under certain culture conditions their levels may reach up to 20% of the total cellular dry weight. In Agrobacterium and Rhizobium species, these molecules contain between 17 and 40 glucose residues linked solely by beta-(1,2) glycosidic bonds. In Bradyrhizobium species, the cyclic beta-glucans are ...

  9. Beta adrenoreceptor subtype cross regulation in the human heart.

    OpenAIRE

    Hall, J. A.; Ferro, A; Dickerson, J. E.; Brown, M. J.

    1993-01-01

    OBJECTIVES--To find out in a prospective study whether beta 1 blocker treatment causes selective beta 2 adrenoreceptor sensitisation, and to find whether such sensitisation is confined to the heart. DESIGN--A placebo controlled cross over study of two weeks of selective beta 1 blocker treatment with 10 mg of bisoprolol daily. SUBJECTS--Six healthy volunteers. OUTCOME MEASURES--Three days after stopping the 10 mg of bisoprolol or placebo, subjects underwent treadmill exercise (to measure cardi...

  10. Osmotic fragility test in heterozygotes for alpha and beta thalassaemia.

    OpenAIRE

    Maccioni, L; Cao, A

    1985-01-01

    This study shows that the combination of heterozygous beta thalassaemia and deletion heterozygous (-alpha/alpha alpha) or homozygous (-alpha/-alpha) alpha+ thalassaemia may result in the production of erythrocytes which have normal mean volume and haemoglobinisation but decreased osmotic fragility. Based on this finding and previous studies, which have shown that beta thalassaemia screening by the osmotic fragility test may miss a significant proportion of beta thalassaemia heterozygotes, we ...

  11. Pharmacokinetics of sex steroids in patients with beta thalassaemia major.

    OpenAIRE

    Katz, M; De Sanctis, V.; Vullo, C; Wonke, B; McGarrigle, H. H.; Bagni, B

    1993-01-01

    AIMS--To assess the pharmacokinetics of oral, intramuscular, or transdermal hormone replacement in patients with beta thalassaemia major. METHODS--Oral (testosterone undecanoate 40 mg) and intramuscular (testosterone propionate 15 mg, phenylpropionate 30 mg, isocaproate 30 mg and decanoate 50 mg) testosterone and transdermal (17 beta oestradiol 25 micrograms and 50 micrograms) oestradiol were evaluated in 21 male (16-29 years) and 11 female (19-26 years) patients with beta thalassaemia major ...

  12. Isospin and quarks in nuclear beta-decay

    International Nuclear Information System (INIS)

    This paper exposes in some detail the technical problems relating to the extraction of the vector coupling constant from the beta decay of complex nuclei. It also considers the extraction of the axial coupling constant from the beta-decay of the neutron. The internal consistency of all data relating to beta-decay, including that of the muon, is also examined, within the standard model, with a view to the possible intervention of WR. (Author) 52 refs., 4 figs., 2 tabs

  13. Time-Varying Beta: A Boundedly Rational Equilibrium Approach

    OpenAIRE

    Carl Chiarella; Roberto Dieci; Xue-Zhong He

    2010-01-01

    By taking into account conditional expectations and the dependence of the systematic risk of asset returns on micro- and macro-economic factors, the conditional CAPM with time-varying betas displays superiority in explaining the cross-section of returns and anomalies in a number of empirical studies. Most of the literature on time-varying beta is motivated by econometric estimation rather than explicit modelling of the stochastic behaviour of betas through agents' behaviour. Within the mean-v...

  14. Interactions between Polymyxa betae and plant systemic defense ways

    OpenAIRE

    Desoignies, Nicolas; Schramme, Florence; Legrève, Anne; Vienna Interntational Plant Conference Association - Plant Diseases and resistance mechanisms

    2013-01-01

    Polymyxa betae is the vector of Beet necrotic yellow vein virus (BNYVV), the causal agent of sugar beet rhizomania disease. Because of the widespread use of cultivars partially resistant to BNYVV, resistance breaking BNYVV isolates have been reported. In order to develop alternative control strategies, we investigated interactions between P. betae and plant defenses. A first set of bioassays was conducted in order to assess P. betae infection after the elicitation of inducible defenses in sug...

  15. Evaluation of the instrument correction factors need in beta dosimetry

    International Nuclear Information System (INIS)

    A wide variety of portable survey instruments using Geiger-Mueller (GM) detectors, ionization chambers, or scintillation detectors exists for the measurement of gamma dose rates. Generally, the same instruments are used for beta monitoring, but the beta response of these instruments has been secondary to their development, calibration, and use; information on the beta response is difficult to obtain and seldom provided by the manufacturer. This paper summarizes observations on energy, angular, and source-geometry response of survey instruments

  16. Phenotypic detection of beta-lactamases production in enterobacteriaceae

    OpenAIRE

    Ćirković Ivana; Pavlović Ljiljana; Konstantinović Neda; Kostić Katarina; Jovanović Snežana; Đukić Slobodanka

    2014-01-01

    Introduction. Beta-lactam antibiotics are the most commonly used antibacterial drugs. However, many bacteria have developed resistance to these antibiotics, and the most common form of resistance is the production of beta-lactamase enzymes. Many members of the Enterobacteriaceae family produce different types of these enzymes. Objective. The aim of this study was to perform phenotypic detection of production and identification of beta-lactamase type in Ente...

  17. Mitochondrial function in normal and diabetic beta-cells

    OpenAIRE

    Maechler, Pierre; Wollheim, Claes

    2001-01-01

    The aetiology of type 2, or non-insulin-dependent, diabetes mellitus has been characterized in only a limited number of cases. Among these, mitochondrial diabetes, a rare subform of the disease, is the consequence of pancreatic beta-cell dysfunction caused by mutations in mitochondrial DNA, which is distinct from the nuclear genome. The impact of such mutations on beta-cell function reflects the importance of mitochondria in the control of insulin secretion. The beta-cell mitochondria serve a...

  18. New Insights in the Amyloid-Beta Interaction with Mitochondria

    OpenAIRE

    Carlos Spuch; Saida Ortolano; Carmen Navarro

    2012-01-01

    Biochemical and morphological alterations of mitochondria may play an important role in the pathogenesis of Alzheimer’s disease (AD). Particularly, mitochondrial dysfunction is a hallmark of amyloid-beta-induced neuronal toxicity in Alzheimer’s disease. The recent emphasis on the intracellular biology of amyloid-beta and its precursor protein (APP) has led researchers to consider the possibility that mitochondria-associated and mitochondrial amyloid-beta may directly cause neurotoxicity. Both...

  19. Marginal versus average beta of equity under corporate taxation

    OpenAIRE

    Lund, Diderik

    2009-01-01

    Even for fully equity-financed firms there may be substantial effects of taxation on the after-tax cost of capital. Among the few studies of these effects, even fewer identify all effects correctly. When marginal investment is taxed together with inframarginal, marginal beta differs from average if there are investmentrelated deductions like depreciation. To calculate asset betas, one should not only "unlever" observed equity betas, but "untax" and "unaverage" them. Risky tax claims are value...

  20. Background capabilities of pixel detectors for double beta decay measurements

    Energy Technology Data Exchange (ETDEWEB)

    Cermak, Pavel, E-mail: pavel.cermak@utef.cvut.cz [Institute of Experimental and Applied Physics, CTU in Prague, 12800 Prague (Czech Republic); Stekl, Ivan; Bocarov, Viktor; Jose, Joshy M.; Jakubek, Jan; Pospisil, Stanislav [Institute of Experimental and Applied Physics, CTU in Prague, 12800 Prague (Czech Republic); Fiederle, Michael; Fauler, Alex [Freiburger Materialforschungszentrum, Albert-Ludwigs-Universitaet Freiburg, D-79104 Freiburg (Germany); Zuber, Kai [Institut fuer Kern- und Teilchenphysik, Technische Universitaet Dresden, 01069 Dresden (Germany); Loaiza, Pia [Laboratoire Souterrain de Modane, 73500 Modane (France); Shitov, Yuriy [Joint Institute for Nuclear Research, 141980 Dubna (Russian Federation)

    2011-05-15

    We discuss the possible use of a progressive detection technique based on pixel detectors for the study of double beta decay ({beta}{beta}) processes. A series of background measurements in various environments (surface laboratory, underground laboratory, with and without Pb shielding) was performed using the TimePix silicon hybrid pixel device. The pixel detector response to the natural background and intrinsic background properties measured by a low-background HPGe detector are presented.

  1. ADAM12-mediated focal adhesion formation is differently regulated by beta1 and beta3 integrins

    DEFF Research Database (Denmark)

    Thodeti, Charles Kumar; Frohlich, Camilla; Nielsen, Christian Kamp;

    2005-01-01

    ADAM12, adisintegrin and metalloprotease, has been demonstrated to be upregulated in human malignant tumors and to accelerate the malignant phenotype in a mouse model for breast cancer. ADAM12 is a substrate for beta1 integrins and may affect tumor and stromal cell behavior through its binding to...

  2. Neuroinflammation and Complexes of 17 beta-Hydroxysteroid Dehydrogenase type 10-Amyloid beta in Alzheimer's Disease

    Czech Academy of Sciences Publication Activity Database

    Krištofíková, Z.; Řípová, D.; Bartoš, A.; Bocková, Markéta; Hegnerová, Kateřina; Říčný, J.; Čechová, L.; Vrajová, M.; Homola, Jiří

    2013-01-01

    Roč. 10, č. 2 (2013), s. 165-173. ISSN 1567-2050 R&D Projects: GA MZd(CZ) NT11225 Institutional support: RVO:67985882 Keywords : Amyloid beta * mitochondrial enzyme * Alzheimer 's disease Subject RIV: JB - Sensors, Measurment, Regulation Impact factor: 3.796, year: 2013

  3. Noncovalent Interaction Energies in Covalent Complexes: TEM-1 beta-Lactamase and beta-Lactams

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Xiaojun; Minasov, George; Shoichet, Brian K. (NWU)

    2010-03-08

    The class A {beta}-lactamase TEM-1 is a key bacterial resistance enzyme against {beta}-lactam antibiotics, but little is known about the energetic bases for complementarity between TEM-1 and its inhibitors. Most inhibitors form a covalent adduct with the catalytic Ser70, making the measurement of equilibriumconstants, and hence interaction energies, technically difficult. This study evaluates noncovalent interactions withincovalent complexes by examining the differential stability of TEM-1 and its inhibitor adducts. The thermal denaturation of TEM-1 follows a two-state, reversible model with a melting temperature (T{sub m}) of 51.6 C and a van't Hoff enthalpy of unfolding ({Delta}H{sub VH}) of 146.2 kcal/mol at pH 7.0. The stability of the enzyme changes on forming an inhibitor adduct. As expected, some inhibitors stabilize TEM-1; transition-state analogues increase the T{sub m} by up to 3.7 C(1.7 kcal/mol). Surprisingly, all {beta}-lactam covalent acyl-enzyme complexes tested destabilize TEM-1 significantly relative to the apoenzyme. For instance, the clinically used inhibitor clavulanic acid and the {beta}-lactamase-resistant {beta}-lactams moxalactam and imipenem destabilize TEM-1 by over 2.6 C (1.2 kcal/mol) in their covalent adducts. Based on the structure of the TEM-1/imipenem complex (Maveyraud et al., J Am Chem Soc 1998;120:9748-52), destabilization by moxalactam and imipenem is thought to be caused by a steric clash between the side-chain of Asn132 and the 6(7)-{alpha} group of these {beta}-lactams. To test this hypothesis, the mutant enzyme N132A was made. In contrast with wild-type, the covalent complexes between N132A and both imipenem and moxalactam stabilize the enzyme, consistent with the hypothesis. To investigate the structural bases of this dramatic change instability, the structure of N132A/imipenem was determined by X-ray crystallography. In the complex with N132A, imipenemadopts a very different conformation from that observed in the wild

  4. Bremsstrahlung dose of therapeutic beta nuclides in bone and muscle

    OpenAIRE

    Manjunatha, H. C.

    2013-01-01

    In the nuclear medicine, beta nuclides are released during the treatment. This beta interacts with bone and muscle and produces external Bremsstrahlung (EB) radiation. Present work formulated a new method to evaluate the EB spectrum and hence the Bremsstrahlung dose of therapeutic beta nuclides (Lu-177, Sr-90, Sm-153, I-153, Cs-137, Au-201, Dy-165, Mo-99, Sr-89, Fe-59, P-32, Ho-166, Sr-92, Re-188, Y-90, Pr-147, Co-60, K-42) in bone and muscle. The Bremsstrahlung yields of these beta nuclides ...

  5. Properties of a commercial extrapolation chamber in beta radiation fields

    International Nuclear Information System (INIS)

    A commercial extrapolation chamber (PTW, Germany) was tested in different beta radiation fields and its properties investigated. Its usefulness for beta radiation calibration and dosimetry was demonstrated. The Beta Secondary Standard setup of the IPEN calibration laboratory was utilized. This system, developed by the Physikalisch-Tecknische Bundesanstalt, Brunswick (Germany) and manufactured by Buchler and Co., consists of a source stand, a control unit with timer and four interchangeable beta sources: 90Sr-90Y (1850 and 74 MBq), 204Tl (18,5 MBq) ionization current detection. The variable volume ionization chamber of cylindrical form is provided with different collecting electrodes of tissue equivalent material and Mylar entrance windows of different thickesses

  6. International society of sports nutrition position stand: Beta-Alanine.

    Science.gov (United States)

    Trexler, Eric T; Smith-Ryan, Abbie E; Stout, Jeffrey R; Hoffman, Jay R; Wilborn, Colin D; Sale, Craig; Kreider, Richard B; Jäger, Ralf; Earnest, Conrad P; Bannock, Laurent; Campbell, Bill; Kalman, Douglas; Ziegenfuss, Tim N; Antonio, Jose

    2015-01-01

    The International Society of Sports Nutrition (ISSN) provides an objective and critical review of the mechanisms and use of beta-alanine supplementation. Based on the current available literature, the conclusions of the ISSN are as follows: 1) Four weeks of beta-alanine supplementation (4-6 g daily) significantly augments muscle carnosine concentrations, thereby acting as an intracellular pH buffer; 2) Beta-alanine supplementation currently appears to be safe in healthy populations at recommended doses; 3) The only reported side effect is paraesthesia (tingling), but studies indicate this can be attenuated by using divided lower doses (1.6 g) or using a sustained-release formula; 4) Daily supplementation with 4 to 6 g of beta-alanine for at least 2 to 4 weeks has been shown to improve exercise performance, with more pronounced effects in open end-point tasks/time trials lasting 1 to 4 min in duration; 5) Beta-alanine attenuates neuromuscular fatigue, particularly in older subjects, and preliminary evidence indicates that beta-alanine may improve tactical performance; 6) Combining beta-alanine with other single or multi-ingredient supplements may be advantageous when supplementation of beta-alanine is high enough (4-6 g daily) and long enough (minimum 4 weeks); 7) More research is needed to determine the effects of beta-alanine on strength, endurance performance beyond 25 min in duration, and other health-related benefits associated with carnosine. PMID:26175657

  7. Microstructures of duplex (beta + gamma) silver-tin alloys.

    Science.gov (United States)

    Abbott, J R; Miller, D R; Netherway, D J

    1985-05-01

    The microstructures of (beta + gamma) silver-tin alloys are especially influenced by both homogenization temperature and subsequent heat treatment. When the alloy is cooled from homogenization temperatures above approximately 200 degrees C, lenticular regions of the ordered orthorhombic gamma phase precipitate from within the disordered h.c.p. beta phase on three structurally equivalent planes, (1210), (1120), and (2110), to form a Widmanstatten structure. When the duplex alloys were homogenized at temperatures below approximately 200 degrees C, where the beta/(beta + gamma) phase boundary is vertical, these structures were not observed. PMID:3858310

  8. Ubuntu 6.10 Edgy Beta 1发布

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    近日,Ubuntu项目发布Ubuntu 6.10 Edgy Eft Beta 1版本,Edgy Eft Beta 1包含新的2.6.17版本内核、Xorg 7.1、GNOME 2.16正式版、新的Firefox浏览器Firefox2.0 Beta2、OpenOffice.org2.0.4RC2版本、聊天软件Gaim的新版本2.0 Beta3.1和新的init系统。

  9. Beta-thalassaemia trait: haematological parameters

    International Nuclear Information System (INIS)

    Thalassaemia syndromes are a group of hereditary disorders characterised by a genetic deficiency in the synthesis of --globin genes. The objective of this study was to determine the haematological features -thalassaemia trait (BTT), and to determine the sensitivity of Mean Corpuscular Volume (MCV), Mean Corpuscular Haemoglobin (MCH) and -thalassaemia trait. Methods: A descriptive study was conducted in Hayatabad Medical Complex, Peshawar from May 2009 to May 2010 with 203 subjects having BTT. Blood samples were collected in EDTA anti-coagulated tubes. RBC indices were taken as part of complete blood count (CBC) by haematology analyser, and Haemoglobin (Hb) electrophoresis was done to determine the HbA2 percentage. The data was collected and analyzed on statistical software for demographic details, RBC indices and HBA2 levels. Results: Out of 203 patients, 92 (45%) were males and 111 (55%) were females. Most patients tested were in the 15-45 year age group. One-hundred-sixty (79%) patients had anaemia. MCV was lower than 76 fl in all the cases. Mean MCV was 59.1 fl. MCH was low, the mean MCH being 19.3 g/dl. MCH <26 gave sensitivity of 99% in detecting BTT. We calculated MI for these cases and found out that it was <12 in 75% of cases and <15 in 197 (97%). Conclusion: Beta-thalassaemia traits present with a microcytic hypochromic blood picture, detected on simple haematology analysers as low MCV and MCH and MI which provide a beta- thalassaemia trait. (author)

  10. Neutrinoless double beta decay search with SNO+

    Science.gov (United States)

    Lozza, V.

    2014-01-01

    The SNO+ experiment is the follow up of SNO. The detector is located 2 km underground in the Vale Canada Ltd.'s Creighton Mine near Sudbury, Ontario, Canada. The active volume of the detector consists of 780 tonnes of Linear Alkyl Benzene (LAB) in an acrylic vessel of 12 m diameter, surrounded by about 9500 PMTs. The main goal of the SNO+ experiment is the search for neutrinoless double beta decay of 130Te. With an initial loading of 0.3% of natural tellurium (nearly 800 kg of 130Te), it is expected to reach a sensitivity on the effective Majorana neutrino mass of about 100 meV after several years of data taking. Designed as a general purpose neutrino experiment, other exciting physical goals can be explored, like the measurement of reactor neutrino oscillations and geo-neutrinos in a geologically-interesting location, watch of supernova neutrinos and studies of solar neutrinos. A first commissioning phase with water filled detector will start at the end of 2013, while the double beta decay phase will start in 2015.

  11. Semiconductor detectors and double beta decay

    International Nuclear Information System (INIS)

    Theoretical physicists have devoted great effort to developing an adequate theory for linking the weak, electromagnetic, and strong forces of nature. Recent theoretical studies and observations of the stability of galaxies have strongly indicated the presence of large amounts of invisible mass. One element in the uncertainty associated with missing mass is the question of whether the neutrino has rest mass. A better understanding of the neutrino, explored in this paper by the possibility of double beta decay in the germanium 76 isotope, could perhaps provide some answers. Nuclear transitions are only energetically possible where the final nucleus is more tightly bound than its parent. The decay of germanium 76 to arsenic 76 is not energetically possible because the arsenic isotope is about 0.9 MeV less tightly bound than the germanium. The selenium 76 isotope, on the other hand, is about 2 MeV more tightly bound; therefore, a transition involving emission of two electrons by a germanium 76 nucleus to form a selenium 76 nucleus is energetically possible. The total energy release in kinetic energy of the beta particles and corresponding neutrinos from the excited daughter product is determined by the energy difference. This energetically possible event, if observed, will provide a breakthrough in understanding the universe. This paper discusses the underlying theory and a germanium detector experiment which could make such a contribution to the resolution of this question

  12. Exchange effects in double beta decay

    International Nuclear Information System (INIS)

    Over the past decade there has been very impressive progress in the laboratory study of double beta decay with very precise limits on 0-neutrino decay in /sup 76/Ge, the imminent prospect of the observation of 2-neutrino decay in /sup 100/Mo and the first laboratory observation of 2-neutrino decay in /sup 82/Se. For the last case, the laboratory rate is in essential agreement with geochemical results and in reasonable agreement with theoretical predictions based on a full shell model calculation. The motivation underlying the resurgence of interest in double beta decay is the hope that the observation of, or limits on the 0-neutrino mode will provide information about the nature of the neutrino. This clearly requires confidence in the nuclear matrix elements involved in the transition. The shell model calculations do not agree well with the geochemical values for /sup 130/Te, which has led to a spate of papers offering specific fixes for the problem. In this contribution we shall not comment on any of the specific nuclear calculations, rather we make some remarks which should be relevant to any model calculation. 11 refs., 1 tab

  13. STIS Coronagraphic Observations of Beta Pictoris

    CERN Document Server

    Heap, S R; Lanz, T M; Cornett, R H; Hubeny, I; Maran, S P; Woodgate, B E; Heap, Sara R.; Lindler, Don J.; Lanz, Thierry M.; Cornett, Robert H.; Hubeny, Ivan; Maran, Stephen P.; Woodgate, Bruce

    1999-01-01

    We present new coronagraphic images of Beta Pictoris obtained with the Space Telescope Imaging Spectrograph (STIS) in September 1997. The high-resolution images (0.1") clearly detect the circumstellar disk as close as 0.75" to the star, corresponding to a projected radius of 15 AU. The images define the warp in the disk with greater precision and at closer radii to Beta Pic than do previous observations. They show that the warp can be modelled by the projection of two components: the main disk, and a fainter component, which is inclined to the main component by 4-5 degrees, and which extends only as far as ~4" from the star. We interpret the main component as arising primarily in the outer disk and the tilted component as defining the inner region of the disk. The observed properties of the warped inner disk are inconsistent with a driving force from stellar radiation. However, warping induced by the gravitational potential of one or more planets is consistent with the data. Using models of planet-warped disk...

  14. The NEXT double beta decay experiment

    Science.gov (United States)

    Laing, A.; NEXT Collaboration

    2016-05-01

    NEXT (Neutrino Experiment with a Xenon TPC) is a neutrinoless double-beta (ββ0v) decay experiment at Laboratorio Subterraneo de Canfranc (LSC). It is an electroluminescent Time Projection Chamber filled with high pressure 136Xe gas with separated function capabilities for calorimetry and tracking. Energy resolution and background suppression are the two key features of any neutrinoless double beta decay experiment. NEXT has both good energy resolution (handle for background identification provided by track reconstruction. We expect a background rate of 4 × 10-4 counts keV-1 kg-1 yr-1, and a sensitivity to the Majorana neutrino mass of between 80-160 meV (depending on NME) after a run of 3 effective years of the 100 kg scale NEXT-100 detector. The initial phase of NEXT-100, called NEW, is currently being commissioned at LSC. It will validate the NEXT background rate expectations and will make first measurements of the two neutrino ββ2v mode of 136Xe. Furthermore, the NEXT technique can be extrapolated to the tonne scale, thus allowing the full exploration of the inverted hierarchy of neutrino masses. These proceedings review NEXT R&D results, the status of detector commissioning at LSC and the NEXT physics case.

  15. Neutrinoless double beta decay search with SNO+

    Directory of Open Access Journals (Sweden)

    Lozza V.

    2014-01-01

    Full Text Available The SNO+ experiment is the follow up of SNO. The detector is located 2 km underground in the Vale Canada Ltd.’s Creighton Mine near Sudbury, Ontario, Canada. The active volume of the detector consists of 780 tonnes of Linear Alkyl Benzene (LAB in an acrylic vessel of 12 m diameter, surrounded by about 9500 PMTs. The main goal of the SNO+ experiment is the search for neutrinoless double beta decay of 130Te. With an initial loading of 0.3% of natural tellurium (nearly 800 kg of 130Te, it is expected to reach a sensitivity on the effective Majorana neutrino mass of about 100 meV after several years of data taking. Designed as a general purpose neutrino experiment, other exciting physical goals can be explored, like the measurement of reactor neutrino oscillations and geo-neutrinos in a geologically-interesting location, watch of supernova neutrinos and studies of solar neutrinos. A first commissioning phase with water filled detector will start at the end of 2013, while the double beta decay phase will start in 2015.

  16. A background free double beta decay experiment

    CERN Document Server

    Giomataris, Ioannis

    2010-01-01

    We present a new detection scheme for rejecting backgrounds in neutrino less double beta decay experiments. It relies on the detection of Cherenkov light emitted by electrons in the MeV region. The momentum threshold is tuned to reach a good discrimination between background and good events. We consider many detector concepts and a range of target materials. The most promising is a high-pressure 136Xe emitter for which the required energy threshold is easily adjusted. Combination of this concept and a high pressure Time Projection Chamber could provide an optimal solution. A simple and low cost effective solution is to use the Spherical Proportional Counter that provides two delayed signals from ionization and Cherenkov light. In solid-state double beta decay emitters, because of their higher density, the considered process is out of energy range. An alternative solution could be the development of double decay emitters with lower density by using for instance the aerogel technique. It is surprising that a te...

  17. Ca2+-dependent dephosphorylation of kinesin heavy chain on beta-granules in pancreatic beta-cells. Implications for regulated beta-granule transport and insulin exocytosis

    Science.gov (United States)

    Donelan, Matthew J.; Morfini, Gerardo; Julyan, Richard; Sommers, Scott; Hays, Lori; Kajio, Hiroshi; Briaud, Isabelle; Easom, Richard A.; Molkentin, Jeffery D.; Brady, Scott T.; Rhodes, Christopher J.

    2002-01-01

    The specific biochemical steps required for glucose-regulated insulin exocytosis from beta-cells are not well defined. Elevation of glucose leads to increases in cytosolic [Ca2+]i and biphasic release of insulin from both a readily releasable and a storage pool of beta-granules. The effect of elevated [Ca2+]i on phosphorylation of isolated beta-granule membrane proteins was evaluated, and the phosphorylation of four proteins was found to be altered by [Ca2+]i. One (a 18/20-kDa doublet) was a Ca2+-dependent increase in phosphorylation, and, surprisingly, three others (138, 42, and 36 kDa) were Ca2+-dependent dephosphorylations. The 138-kDa beta-granule phosphoprotein was found to be kinesin heavy chain (KHC). At low levels of [Ca2+]i KHC was phosphorylated by casein kinase 2, but KHC was rapidly dephosphorylated by protein phosphatase 2B beta (PP2Bbeta) as [Ca2+]i increased. Inhibitors of PP2B specifically reduced the second, microtubule-dependent, phase of insulin secretion, suggesting that dephosphorylation of KHC was required for transport of beta-granules from the storage pool to replenish the readily releasable pool of beta-granules. This is distinct from synaptic vesicle exocytosis, because neurotransmitter release from synaptosomes did not require a Ca2+-dependent KHC dephosphorylation. These results suggest a novel mechanism for regulating KHC function and beta-granule transport in beta-cells that is mediated by casein kinase 2 and PP2B. They also implicate a novel regulatory role for PP2B/calcineurin in the control of insulin secretion downstream of a rise in [Ca2+]i.

  18. Cdk4 regulates recruitment of quiescent beta-cells and ductal epithelial progenitors to reconstitute beta-cell mass.

    Directory of Open Access Journals (Sweden)

    Ji-Hyeon Lee

    Full Text Available Insulin-producing pancreatic islet beta cells (beta-cells are destroyed, severely depleted or functionally impaired in diabetes. Therefore, replacing functional beta-cell mass would advance clinical diabetes management. We have previously demonstrated the importance of Cdk4 in regulating beta-cell mass. Cdk4-deficient mice display beta-cell hypoplasia and develop diabetes, whereas beta-cell hyperplasia is observed in mice expressing an active Cdk4R24C kinase. While beta-cell replication appears to be the primary mechanism responsible for beta-cell mass increase, considerable evidence also supports a contribution from the pancreatic ductal epithelium in generation of new beta-cells. Further, while it is believed that majority of beta-cells are in a state of 'dormancy', it is unclear if and to what extent the quiescent cells can be coaxed to participate in the beta-cell regenerative response. Here, we address these queries using a model of partial pancreatectomy (PX in Cdk4 mutant mice. To investigate the kinetics of the regeneration process precisely, we performed DNA analog-based lineage-tracing studies followed by mathematical modeling. Within a week after PX, we observed considerable proliferation of islet beta-cells and ductal epithelial cells. Interestingly, the mathematical model showed that recruitment of quiescent cells into the active cell cycle promotes beta-cell mass reconstitution in the Cdk4R24C pancreas. Moreover, within 24-48 hours post-PX, ductal epithelial cells expressing the transcription factor Pdx-1 dramatically increased. We also detected insulin-positive cells in the ductal epithelium along with a significant increase of islet-like cell clusters in the Cdk4R24C pancreas. We conclude that Cdk4 not only promotes beta-cell replication, but also facilitates the activation of beta-cell progenitors in the ductal epithelium. In addition, we show that Cdk4 controls beta-cell mass by recruiting quiescent cells to enter the cell

  19. TGF-{beta}-stimulated aberrant expression of class III {beta}-tubulin via the ERK signaling pathway in cultured retinal pigment epithelial cells

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Eun Jee [Department of Ophthalmology, National Health Insurance Corporation Ilsan Hospital, Gyeonggi-do (Korea, Republic of); Chun, Ji Na; Jung, Sun-Ah [Konyang University Myunggok Medical Research Institute, Kim' s Eye Hospital, Konyang University College of Medicine, Seoul (Korea, Republic of); Cho, Jin Won [Department of Biology, Yonsei University, 134 Shinchon-dong, Seodaemun-gu, Seoul 120-749 (Korea, Republic of); Lee, Joon H., E-mail: joonhlee@konyang.ac.kr [Konyang University Myunggok Medical Research Institute, Kim' s Eye Hospital, Konyang University College of Medicine, Seoul (Korea, Republic of)

    2011-11-18

    Highlights: Black-Right-Pointing-Pointer TGF-{beta} induces aberrant expression of {beta}III in RPE cells via the ERK pathway. Black-Right-Pointing-Pointer TGF-{beta} increases O-GlcNAc modification of {beta}III in RPE cells. Black-Right-Pointing-Pointer Mature RPE cells have the capacity to express a neuron-associated gene by TGF-{beta}. -- Abstract: The class III {beta}-tubulin isotype ({beta}{sub III}) is expressed exclusively by neurons within the normal human retina and is not present in normal retinal pigment epithelial (RPE) cells in situ or in the early phase of primary cultures. However, aberrant expression of class III {beta}-tubulin has been observed in passaged RPE cells and RPE cells with dedifferentiated morphology in pathologic epiretinal membranes from idiopathic macular pucker, proliferative vitreoretinopathy (PVR) and proliferative diabetic retinopathy (PDR). Transforming growth factor-{beta} (TGF-{beta}) has been implicated in dedifferentiation of RPE cells and has a critical role in the development of proliferative vitreoretinal diseases. Here, we investigated the potential effects of TGF-{beta} on the aberrant expression of class III {beta}-tubulin and the intracellular signaling pathway mediating these changes. TGF-{beta}-induced aberrant expression and O-linked-{beta}-N-acetylglucosamine (O-GlcNac) modification of class III {beta}-tubulin in cultured RPE cells as determined using Western blotting, RT-PCR and immunocytochemistry. TGF-{beta} also stimulated phosphorylation of ERK. TGF-{beta}-induced aberrant expression of class III {beta}-tubulin was significantly reduced by pretreatment with U0126, an inhibitor of ERK phosphorylation. Our findings indicate that TGF-{beta} stimulated aberrant expression of class III {beta}-tubulin via activation of the ERK signaling pathway. These data demonstrate that mature RPE cells have the capacity to express a neuron-associated gene in response to TGF-{beta} stimulation and provide useful information

  20. Coherent dynamics of exciatable coupled beta-cells

    DEFF Research Database (Denmark)

    Sørensen, Mads P; Petersen, Mette Vesterager; Aslanidi, Oleg

    Propagation of excitation waves through a cluster of insulin-secreting beta-cells (a pancreatic islet of Langerhans) is modelled, and the results are related to recent image analysis experiments.......Propagation of excitation waves through a cluster of insulin-secreting beta-cells (a pancreatic islet of Langerhans) is modelled, and the results are related to recent image analysis experiments....

  1. Characterization of beta-lactamases in situ on polyacrylamide gels.

    OpenAIRE

    Sanders, C C; Sanders, W E; Moland, E S

    1986-01-01

    An inhibitor-based characterization system which allowed the identification of beta-lactamases after isoelectric focusing on polyacrylamide gels was developed. This system, using potassium clavulanate and oxacillin, distinguished type I chromosomally mediated enzymes from other beta-lactamases of gram-negative bacteria.

  2. Overview of total beta activity index and beta rest in surface waters of the Spanish rivers; Vision general del indice de actividad beta total y beta resto en las aguas superficiales de los rios espanoles

    Energy Technology Data Exchange (ETDEWEB)

    Pujol, L.; Payeras, J.; Pablo, M. A. de

    2013-07-01

    This work aims to give an overview of the index of total beta activity and the activity index beta rest in surface waters of the main Spanish rivers. These indices are a parameter over water quality that CEDEX comes determined by order of the Ministry of Agriculture, Food and Environment, in water policy. (Author)

  3. Free infinite divisibility for beta distributions and related ones

    OpenAIRE

    Hasebe, Takahiro

    2013-01-01

    We prove that many of beta, beta prime, gamma, inverse gamma, Student t- and ultraspherical distributions are freely infinitely divisible, but some of them are not. The latter negative result follows from a local property of probability density functions. Moreover, we show that the Gaussian, many of ultraspherical and Student t-distributions have free divisibility indicator 1.

  4. Free infinite divisibility for beta distributions and related ones

    OpenAIRE

    Hasebe, Takahiro

    2013-01-01

    We prove that many of beta, beta prime, gamma, inverse gamma, Student t- and ultraspherical distributions are freely infinitely divisible, but some of them are not. The latter negative result follows from a local property of probability density functions. Moreover, we show that the Gaussian, ultraspherical and many of Student t-distributions have free divisibility indicator 1.

  5. Library Book Circulation and the Beta-Binomial Distribution.

    Science.gov (United States)

    Gelman, E.; Sichel, H. S.

    1987-01-01

    Argues that library book circulation is a binomial rather than a Poisson process, and that individual book popularities are continuous beta distributions. Three examples demonstrate the superiority of beta over negative binomial distribution, and it is suggested that a bivariate-binomial process would be helpful in predicting future book…

  6. Novel Beta-Gamma Coincidence Measurements Using Phoswich Detectors

    International Nuclear Information System (INIS)

    The PNNL has developed an Automated Radio-xenon Sampler/Analyzer (ARSA) for the CTBT to measure four radio-xenon isotopes using a beta-gamma coincidence counting detector. A novel method to measure beta-gamma coincidences using a phoswich detector with state-of-the-art pulse shape discrimination techniques has been investigated

  7. Closing in on Mass Production of Mature Human Beta Cells.

    Science.gov (United States)

    Kieffer, Timothy J

    2016-06-01

    Human pluripotent stem cell differentiation protocols based on mimicking developmental pathways are getting close to generating fully fledged pancreatic endocrine cells, including insulin-producing beta cells. However, challenges remain in identifying pathways to trigger the attainment of robust glucose responsiveness that occurs postnatally in beta cells. PMID:27257758

  8. Beta-endorphin in genetically hypoprolactinemic rat: IPL nude rat

    International Nuclear Information System (INIS)

    Beta-endorphin has been reported to regulate not only stress- and suckling-induced but also basal prolactin secretion. In the aim to better evaluate the endogenous beta-endorphin-prolactin interrelation, the authors measured beta-endorphin levels in a new rat strain, genetically hypoprolactinemic and characterized by a total lack of lactation: IPL nude rat. Beta-endorphin was measured using a specific anti-h-β endorphin in plasma and extracts of anterior and neurointermediate lobes of the pituitary, hypothalamus and brain. Pituitary extracts were also chromatographed on Sephadex G50 column. Results obtained showed that in IPL nude females on diestrus and males, the beta-endorphin contents of the neurointermediate lobe was significantly lower than in normal rats, while the values found in the other organs and plasma were similar. However, elution pattern of the anterior pituitary extracts from male rats showed greater immunoactivity eluting as I125 h-beta-endorphin than in normal rat; this was not the case for the female rat. These results are consistent with a differential regulation of beta-endorphin levels of anterior and neurointermediate lobe by catecholamines. Moreover they suggest that PRL secretion was more related to neurointermediate beta-endorphin. 40 references, 2 figures, 4 tables

  9. Experimental method for reactor-noise measurements of effective beta

    International Nuclear Information System (INIS)

    A variance-to-mean noise technique, modified to eliminate systematic errors from drifting of reactor power, has been used to infer integral values of effective beta for uranium and plutonium fueled fast reactor modk-ups. The measurement technique, including corrections for a finite detector-electrometer time response, is described together with preliminary beta measurement results

  10. Reversal of haemochromatotic cardiomyopathy in beta thalassaemia by chelation therapy.

    OpenAIRE

    Politi, A; M. Sticca; Galli, M

    1995-01-01

    Haemochromatotic cardiomyopathy is the main cause of morbidity and mortality in patients with beta thalassaemia major. Once congestive heart failure develops most patients die in a few months. Congestive heart failure was reversed and echocardiographic findings were restored to normal in a 24 year old woman with beta thalassaemia who resumed treatment with chelation therapy (desferrioxamine).

  11. Definition of $\\tan\\beta$ beyond tree-level

    OpenAIRE

    Yamada, Youichi

    1996-01-01

    We study the relation between different renormalization schemes for the parameter $\\tan\\beta$ in the Minimal Supersymmetric Standard Model. The contributions of the third-generation quark-squark loops to the differences between $\\tan\\beta$'s in several schemes are discussed. Their numerical differences are typically within several %.

  12. Role of IL-1beta in type 2 diabetes

    DEFF Research Database (Denmark)

    Dinarello, Charles A; Donath, Marc Y; Mandrup-Poulsen, Thomas

    2010-01-01

    To understand the role of inflammation as the fundamental cause of type 2 diabetes and specifically to examine the contribution of IL-1beta.......To understand the role of inflammation as the fundamental cause of type 2 diabetes and specifically to examine the contribution of IL-1beta....

  13. Search for neutrinoless double beta decay with DCBA

    International Nuclear Information System (INIS)

    A project called DCBA (Drift Chamber Beta-ray Analyzer) is in progress at KEK in order to search for the events of neutrinoless double beta decay. For investigating technical problems, a test apparatus called DCBA-T has been constructed. The preliminary results of its engineering run are described together with the simulation studies of backgrounds originating from 214Bi and 208Tl

  14. Proliferation of sorted human and rat beta cells

    DEFF Research Database (Denmark)

    Parnaud, G; Bosco, D; Berney, T;

    2008-01-01

    The aim of the study was to determine whether purified beta cells can replicate in vitro and whether this is enhanced by extracellular matrix (ECM) and growth factors.......The aim of the study was to determine whether purified beta cells can replicate in vitro and whether this is enhanced by extracellular matrix (ECM) and growth factors....

  15. Postoperative beta irradiation in the treatment of pterygium

    International Nuclear Information System (INIS)

    High recurrence rates are reported after surgical treatment of ptergyia. With the use of beta irradiation, the recurrence rate drops dramatically. This paper describes technic and dosage used in a group of patients receiving postoperative beta irradiation. Two thirds of these patients, however, had at least two surgical procedures. A recurrence rate of 3.5% was observed, with no apparent morbidity

  16. In vitro digestibility of beta-casein and beta-lactoglobulin under simulated human gastric and duodenal conditions: A multi-laboratory evaluation

    DEFF Research Database (Denmark)

    Mandalari, G.; Adel-Patient, K.; Barkholt, Vibeke;

    2009-01-01

    gastroduodenal digestion in the presence or absence of phosphatidylcholine (PC). Both beta-casein and beta-Lg were susceptible to hydrolysis by pepsin and pancreatin in the high-protease assay. In contrast, the kinetics of beta-casein digestion in the low-protease assay were slower, beta-Lg being pepsin...

  17. DNA polymerase-beta is expressed early in neurons of Alzheimer's disease brain and is loaded into DNA replication forks in neurons challenged with beta-amyloid

    NARCIS (Netherlands)

    A. Copani; J.J.M. Hoozemans; F. Caraci; M. Calafiore; E.S. van Haastert; R. Veerhuis; A.J.M. Rozemuller; E. Aronica; M.A. Sortino; F. Nicoletti

    2006-01-01

    Cultured neurons exposed to synthetic beta-amyloid (A beta) fragments reenter the cell cycle and initiate a pathway of DNA replication that involves the repair enzyme DNA polymerase-beta (DNA pol-beta) before undergoing apoptotic death. In this study, by performing coimmunoprecipitation experiments

  18. Antibodies against Pseudomonas aeruginosa chromosomal beta-lactamase inpatients with cystic fibrosis are markers of the development of resistance of P. aeruginosa to beta-lactams

    DEFF Research Database (Denmark)

    Ciofu, O; Giwercman, B; Walter-Rasmussen, J; Pressler, T; Pedersen, S S; Høiby, N

    1995-01-01

    Chromosomal beta-lactamase production is considered to be the most important resistance mechanism of Pseudomonas aeruginosa against beta-lactams. Recently we have detected serum and sputum antibodies against P. aeruginosa chromosomal beta-lactamase (a beta ab), using immunoblotting techniques. In...

  19. Neutrinoless Double Beta Decay: 2015 Review

    Directory of Open Access Journals (Sweden)

    Stefano Dell’Oro

    2016-01-01

    Full Text Available The discovery of neutrino masses through the observation of oscillations boosted the importance of neutrinoless double beta decay (0νββ. In this paper, we review the main features of this process, underlining its key role from both the experimental and theoretical point of view. In particular, we contextualize the 0νββ in the panorama of lepton number violating processes, also assessing some possible particle physics mechanisms mediating the process. Since the 0νββ existence is correlated with neutrino masses, we also review the state of the art of the theoretical understanding of neutrino masses. In the final part, the status of current 0νββ experiments is presented and the prospects for the future hunt for 0νββ are discussed. Also, experimental data coming from cosmological surveys are considered and their impact on 0νββ expectations is examined.

  20. Double beta decay and neutrino mass models

    CERN Document Server

    Helo, J C; Ota, T; Santos, F A Pereira dos

    2015-01-01

    Neutrinoless double beta decay allows to constrain lepton number violating extensions of the standard model. If neutrinos are Majorana particles, the mass mechanism will always contribute to the decay rate, however, it is not a priori guaranteed to be the dominant contribution in all models. Here, we discuss whether the mass mechanism dominates or not from the theory point of view. We classify all possible (scalar-mediated) short-range contributions to the decay rate according to the loop level, at which the corresponding models will generate Majorana neutrino masses, and discuss the expected relative size of the different contributions to the decay rate in each class. We also work out the phenomenology of one concrete 2-loop model in which both, mass mechanism and short-range diagram, might lead to competitive contributions, in some detail.

  1. Reliability for some bivariate beta distributions

    Directory of Open Access Journals (Sweden)

    Nadarajah Saralees

    2005-01-01

    Full Text Available In the area of stress-strength models there has been a large amount of work as regards estimation of the reliability R=Pr( Xbeta. The calculations involve the use of special functions.

  2. A massive neutrino in nuclear beta decay?

    International Nuclear Information System (INIS)

    We have continued our studies of the p-spectrum of 14C using a germanium detector doped with 14C. There is a feature in the β-spectrum 17 keV below the endpoint which could be explained by the hypothesis that there is a heavy neutrino emitted in the β-decay of 14C with a mass of 17±1 keV and an emission probability of 1.26±0.25%. However, we also have performed a high statistics measurement of the inner bremsstrahlung spectrum of 55Fe and find no indication of the emission of a 17-keV neutrino. We conclude that the origin of the ''kink'' that has been observed in some recent beta spectral measurements is not a neutrino

  3. Adjusting the IP $\\beta$ Functions in RHIC

    CERN Document Server

    Wittmer, W; Pilat, F; Ptitsyn, V; Van Zeijts, J

    2004-01-01

    The beta functions at the IP can be adjusted without perturbation of other optics functions via several approaches. In this paper we describe a scheme based on a vector knob, which assigns fixed values to the different tuning quadrupoles and scales them by a common multiplier. The values for the knob vector were calculated for a lattice without any errors using MADX. Previous studies for the LHC [1] have shown that this approach can meet the design goals. A specific feature of the RHIC lattice is the nested power supply system. To cope with the resulting problems a detailed response matrix analysis has been carried out and different sets of knobs were calculated and compared. The knobs were tested at RHIC during the 2004 run and preliminary results are discussed. Simultaneously a new approach to measure the beam sizes of both colliding beams at the IP, based on the tunability provided by the knobs, was developed and tested.

  4. Neutrinoless Double Beta Decay with SNO+

    CERN Document Server

    Hartnell, J

    2012-01-01

    SNO+ will search for neutrinoless double beta decay by loading 780 tonnes of linear alkylbenzene liquid scintillator with O(tonne) of neodymium. Using natural Nd at 0.1% loading will provide 43.7 kg of 150Nd given its 5.6% abundance and allow the experiment to reach a sensitivity to the effective neutrino mass of 100-200 meV at 90% C.L in a 3 year run. The SNO+ detector has ultra low backgrounds with 7000 tonnes of water shielding and self-shielding of the scintillator. Distillation and several other purification techniques will be used with the aim of achieving Borexino levels of backgrounds. The experiment is fully funded and data taking with light-water will commence in 2012 with scintillator data following in 2013.

  5. CPS Transformation of Beta-Redexes

    DEFF Research Database (Denmark)

    Danvy, Olivier; Nielsen, Lasse

    2005-01-01

    The extra compaction of the most compacting CPS transformation in existence, which is due to Sabry and Felleisen, is generally attributed to (1) making continuations occur first in CPS terms and (2) classifying more redexes as administrative. We show that this extra compaction is actually...... independent of the relative positions of values and continuations and furthermore that it is solely due to a context-sensitive transformation of beta-redexes. We stage the more compact CPS transformation into a first-order uncurrying phase and a context-insensitive CPS transformation. We also define a context......-insensitive CPS transformation that provides the extra compaction. This CPS transformation operates in one pass and is dependently typed....

  6. CPS Transformation of Beta-Redexes

    DEFF Research Database (Denmark)

    Danvy, Olivier; Nielsen, Lasse R.

    The extra compaction of the most compacting CPS transformation in existence, which is due to Sabry and Felleisen, is generally attributed to (1) making continuations occur first in CPS terms and (2) classifying more redexes as administrative. We show that this extra compaction is actually...... independent of the relative positions of values and continuations and furthermore that it is solely due to a context-sensitive transformation of beta-redexes. We stage the more compact CPS transformation into a first-order uncurrying phase and a context-insensitive CPS transformation. We also define a context......-insensitive CPS transformation that provides the extra compaction. This CPS transformation operates in one pass and is dependently typed....

  7. Weak decays and double beta decay

    International Nuclear Information System (INIS)

    Work to measure the Σ+ 0 degree differential cross section in the reaction K-p → Σ+π- at several incident K- momenta between 600 and 800 MeV/c as well as the asymmetries in the decays of polarized Σ+'s into protons and neutral pions and of polarized Σ-'s into neutrons and negative pions in collaboration with experimenters from Yale, Brookhaven, and the University of Pittsburgh (Brookhaven experiment 702) has been completed. Data from this experiment is currently being analyzed at Yale. Work is currently underway to develop and construct an experiment to search for neutrinoless double beta decay in thin foils of Mo100 in collaboration with experimenters from Lawrence Berkeley Laboratory. Development work on the solid state silicon detectors should be complete in the next six months and construction should e well underway within the next year

  8. Fluxon Modeling of Low-Beta Plasmas

    CERN Document Server

    DeForest, C E; Forest, Craig E. De; Kankelborg, Charles C.

    2006-01-01

    We have developed a new, quasi-Lagrangian approach for numerical modeling of magnetohydrodynamics in low to moderate $\\beta$ plasmas such as the solar corona. We introduce the concept of a ``fluxon'', a discretized field line. Fluxon models represent the magnetic field as a skeleton of such discrete field lines, and interpolate field values from the geometry of the skeleton where needed, reversing the usual direction of the field line transform. The fluxon skeleton forms the grid for a collection of 1-D Eulerian models of plasma along individual flux tubes. Fluxon models have no numerical resistivity, because they preserve topology explicitly. Our prototype code, \\emph{FLUX}, is currently able to find 3-D nonlinear force-free field solutions with a specified field topology, and work is ongoing to validate and extend the code to full magnetohydrodynamics. FLUX has significant scaling advantages over conventional models: for ``magnetic carpet'' models, with photospheric line-tied boundary conditions, FLUX simul...

  9. A massive neutrino in nuclear beta decay?

    International Nuclear Information System (INIS)

    We have continued our studies of the β-spectrum of 14C using a germanium detector doped with l4C. There is a feature in the β-spectrum 17 keV below the endpoint which could be explained by the hypothesis that there is a heavy neutrino emitted in the β-decay of 14C with a mass of 17±1 keV and an emission probability of 1.26±0.25%. However, we also have performed a high statistics measurement of the inner bremsstrahlung spectrum of 55Fe and find no indication of the emission of a 17-keV neutrino. We conclude that the origin of the ''kink'' that has been observed in some recent beta spectral measurements is not a neutrino

  10. A massive neutrino in nuclear beta decay?

    International Nuclear Information System (INIS)

    We have continued our studies of the β-spectrum of 14C using a germanium detector doped with 14C. There is a feature in the β-spectrum 17 keV below the endpoint which could be explained by the hypothesis that there is a heavy neutrino emitted in the β-decay of 14C with a mass of 17±1 keV and an emission probability of 1.26±0.25%. However, we also have performed a high statistics measurement of the inner bremsstrahlung spectrum of 55Fe and find no indication of the emission of a 17-keV neutrino. We conclude that the origin of the ''kink'' that has been observed in some recent beta spectral measurements is not a neutrino

  11. Nonionic emulsion-mediated synthesis of zeolite beta

    Indian Academy of Sciences (India)

    Yuguo Shen; Ying Zhang; Chao Jin; Ying Cao; Wei Gao; Lishan Cui

    2011-07-01

    Zeolite beta synthesis was first carried out in a newly developed emulsion system containing nonionic polyoxyethylated alkylphenol surfactant, which showed interesting non-conventional features. Compared to the conventional hydrothermal synthesis of zeolite beta, the reported nonionic emulsion system showed a faster nucleation rate. Furthermore, the emulsion system could stabilize the beta product and retarded its further transformation to ZSM-5 even under the high crystallization temperature at 453 K. Additionally, the beta particle size could be tuned by the adoption of different lengths of alkyl chain in the surfactant and cosurfactant. Control experiments showed each emulsion component played a crucial role in the zeolite beta growth. The approach proposed in this paper might be extended to apply for the syntheses of other types of zeolites with particle size under control.

  12. Analysis of production data using the beta-derivative

    Energy Technology Data Exchange (ETDEWEB)

    Idorenyin, E.; Okouma, V.; Mattar, L. [Society of Petroleum Engineers (Canada)

    2011-07-01

    The collection of accurate production data is critical to the evaluation and estimation of reserves. However, in the case of hydrocarbon production from shale and tight sands, traditional decline analysis methods often provide deceptive data. This paper proposes the use of the beta-derivative function to be used as a production analysis tool in conjunction with other evaluations. After reviewing theoretical background, the beta-derivative was applied to production rates and flowing pressures. It was found that the derivative for constant pressure differed from that of constant rate and that the presence of skin altered the beta-derivative. It was also stated that the beta-derivative adds considerable value in the identification of power-law type of flow regimes, as a unique character exists for each regime. Through analysis of rates and pressures, this paper shows how the beta-derivative can be a useful evaluation tool in delineating flow regimes and assisting with data modeling.

  13. Progress in molecular nuclear medicine imaging of pancreatic beta cells

    International Nuclear Information System (INIS)

    Diabetes mellitus is a common and frequently occurring disease which seriously threaten the health of human beings. Type 1 and type 2 diabetes respectively results from being destroyed and insufficient beta-cell mass. The associated symptoms appear until 50%-60% decrease of beta-cell mass. Because pancreas is deeply located in the body, with few beta-cell mass, the current methods of clinical diagnosis are invasive and late. So diagnosis of metabolism disease of beta-cell early non-invasively becomes more and more popular, imaging diagnosis of diabetes mellitus becomes the focus of researches, but how to estimate the mass of beta-cell still an important subject in imaging technology. (authors)

  14. Chronology of endocrine differentiation and beta-cell neogenesis [Review].

    Science.gov (United States)

    Miyatsuka, Takeshi

    2016-03-31

    Diabetes is a chronic and incurable disease, which results from absolute or relative insulin insufficiency. Therefore, pancreatic beta cells, which are the only type of cell that expresses insulin, is considered to be a potential target for the cure of diabetes. Although the findings regarding beta-cell neogenesis during pancreas development have been exploited to induce insulin-producing cells from non-beta cells, there are still many hurdles towards generating fully functional beta cells that can produce high levels of insulin and respond to physiological signals. To overcome these problems, a solid understanding of pancreas development and beta-cell formation is required, and several mouse models have been developed to reveal the unique features of each endocrine cell type at distinct developmental time points. Here I review our understanding of pancreas development and endocrine differentiation focusing on recent progresses in improving temporal cell labeling in vivo. PMID:26615757

  15. Rational numbers with purely periodic $\\beta$-expansion

    CERN Document Server

    Adamczewski, Boris; Siegel, Anne; Steiner, Wolfgang

    2009-01-01

    We study real numbers $\\beta$ with the curious property that the $\\beta$-expansion of all sufficiently small positive rational numbers is purely periodic. It is known that such real numbers have to be Pisot numbers which are units of the number field they generate. We complete known results due to Akiyama to characterize algebraic numbers of degree 3 that enjoy this property. This extends results previously obtained in the case of degree 2 by K. Schmidt, Hama and Imahashi. Let $\\gamma(\\beta)$ denote the supremum of the real numbers $c$ in $(0,1)$ such that all positive rational numbers less than $c$ have a purely periodic $\\beta$-expansion. We prove that $\\gamma(\\beta)$ is irrational for a class of cubic Pisot units that contains the smallest Pisot number $\\eta$. This result is motivated by the observation of Akiyama and Scheicher that $\\gamma(\\eta)=0.666 666 666 086 ...$ is surprisingly close to 2/3.

  16. A system for simultaneous beta and gamma spectroscopy

    Science.gov (United States)

    Farsoni, A. T.; Hamby, D. M.

    2007-08-01

    A state-of-the-art radiation detection system for real-time and simultaneous spectroscopy of beta-particles and gamma-rays has been developed. The system utilizes a triple-layer phoswich detector and a customized Digital Pulse Processor (DPP) designed and built in our laboratory. The DPP board digitally captures the analog signal pulses and, following several digital preprocessing steps, transfers valid pulses to the host computer for further digital processing. A resolving algorithm also was developed to digitally discriminate beta and gamma events, and reconstruct separate beta and gamma-ray energy spectra with minimal crosstalk. The spectrometer has proven to be an effective tool for recording separate beta and gamma-ray spectra from mixed radiation fields. The system as a beta-gamma spectrometer will have broad-ranging applications in nuclear non-proliferation, radioactive waste management, worker safety, systems reliability, dose assessment, and risk analysis.

  17. Beta 1 integrin is essential for teratoma growth and angiogenesis

    DEFF Research Database (Denmark)

    Bloch, W; Forsberg, E; Lentini, S;

    1997-01-01

    Teratomas are benign tumors that form after ectopic injection of embryonic stem (ES) cells into mice and contain derivatives of all primitive germ layers. To study the role of beta 1 integrin during teratoma formation, we compared teratomas induced by normal and beta1-null ES cells. Injection of...... normal ES cells gave rise to large teratomas. In contrast, beta 1-null ES cells either did not grow or formed small teratomas with an average weight of <5% of that of normal teratomas. Histological analysis of beta 1-null teratomas revealed the presence of various differentiated cells, however, a much...... lower number of host-derived stromal cells than in normal teratomas. Fibronectin, collagen I, and nidogen were expressed but, in contrast to normal teratomas, diffusely deposited in beta1-null teratomas. Basement membranes were present but with irregular shape and detached from the cell surface. Normal...

  18. Testing the importance of collective correlations in neutrinoless $\\beta\\beta$ decay

    CERN Document Server

    Menéndez, J; Engel, J; Martínez-Pinedo, G; Rodríguez, T R

    2016-01-01

    We investigate the extent to which theories of collective motion can capture the physics that determines the nuclear matrix elements governing neutrinoless double-beta decay. To that end we calculate the matrix elements for a series of isotopes in the full $pf$ shell, omitting no spin-orbit partners. With the inclusion of isoscalar pairing, a separable collective Hamiltonian that is derived from the shell model effective interaction reproduces the full shell-model matrix elements with good accuracy. A version of the generator coordinate method that includes the isoscalar pairing amplitude as a coordinate also reproduces the shell model results well, an encouraging result for theories of collective motion, which can include more single-particle orbitals than the shell model. We briefly examine heavier nuclei relevant for experimental double-beta decay searches, in which shell-model calculations with all spin-orbit partners are not feasible; our estimates suggest that isoscalar pairing also plays a significant ...

  19. Amyloid-beta Alzheimer targets — protein processing, lipid rafts, and amyloid-beta pores

    Science.gov (United States)

    Arbor, Sage C.; LaFontaine, Mike; Cumbay, Medhane

    2016-01-01

    Amyloid beta (Aβ), the hallmark of Alzheimer’s Disease (AD), now appears to be deleterious in its low number aggregate form as opposed to the macroscopic Aβ fibers historically seen postmortem. While Alzheimer targets, such as the tau protein, amyloid precursor protein (APP) processing, and immune system activation continue to be investigated, the recent discovery that amyloid beta aggregates at lipid rafts and likely forms neurotoxic pores has led to a new paradigm regarding why past therapeutics may have failed and how to design the next round of compounds for clinical trials. An atomic resolution understanding of Aβ aggregates, which appear to exist in multiple conformations, is most desirable for future therapeutic development. The investigative difficulties, structures of these small Aβ aggregates, and current therapeutics are summarized in this review.

  20. Shell Model description of the {beta}{beta} decay of {sup 136}Xe

    Energy Technology Data Exchange (ETDEWEB)

    Caurier, E.; Nowacki, F. [IPHC, IN2P3-CNRS/Universite Louis Pasteur BP 28, F-67037 Strasbourg Cedex 2 (France); Poves, A., E-mail: alfredo.poves@uam.es [Departamento de Fisica Teorica, Universidad Autonoma de Madrid and Instituto de Fisica Teorica, UAM/CSIC, E-28049, Madrid (Spain)

    2012-05-01

    We study in this Letter the double beta decay of {sup 136}Xe with emission of two neutrinos which has been recently measured by the EXO-200 Collaboration. We use the same shell model framework, valence space, and effective interaction that we have already employed in our calculation of the nuclear matrix element (NME) of its neutrinoless double beta decay. Using the quenching factor of the Gamow-Teller operator which is needed to reproduce the very recent high resolution {sup 136}Xe ({sup 3}He, t) {sup 136}Cs data, we obtain a nuclear matrix element M{sup 2{nu}}=0.025 MeV{sup -1} compared with the experimental value M{sup 2{nu}}=0.019(2) MeV{sup -1}.

  1. Amyloid-beta Alzheimer targets - protein processing, lipid rafts, and amyloid-beta pores.

    Science.gov (United States)

    Arbor, Sage C; LaFontaine, Mike; Cumbay, Medhane

    2016-03-01

    Amyloid beta (Aβ), the hallmark of Alzheimer's Disease (AD), now appears to be deleterious in its low number aggregate form as opposed to the macroscopic Aβ fibers historically seen postmortem. While Alzheimer targets, such as the tau protein, amyloid precursor protein (APP) processing, and immune system activation continue to be investigated, the recent discovery that amyloid beta aggregates at lipid rafts and likely forms neurotoxic pores has led to a new paradigm regarding why past therapeutics may have failed and how to design the next round of compounds for clinical trials. An atomic resolution understanding of Aβ aggregates, which appear to exist in multiple conformations, is most desirable for future therapeutic development. The investigative difficulties, structures of these small Aβ aggregates, and current therapeutics are summarized in this review. PMID:27505013

  2. Treating High Blood Pressure: Is a Beta-Blocker Drug Right for You?

    Science.gov (United States)

    ... High Blood Pressure: Is a Beta-blocker Drug Right for You? What are beta-blockers? Beta-blockers ... talk with your doctor about which drugs are right for you. If your blood pressure is slightly ...

  3. Characterization of a neutron–beta counting system with beta-delayed neutron emitters

    OpenAIRE

    Agramunt, J.; Tain, J.L.; Gómez-Hornillos, M. B.; GARCIA A. R.; Albiol, F; Algora, A.; Caballero-Folch, R.; CALVIÑO F.; Cano-Ott, D.; Cortés, G.; Domingo-Pardo, C.; Eronen, Tommi; Gelletly, W.; Gorelov, Dmitry; Gorlychev, V.

    2016-01-01

    A new detection system for the measurement of beta-delayed neutron emission probabilities has been characterized using fission products with well known β-delayed neutron emission properties. The setup consists of BELEN-20, a 4π neutron counter with twenty 3He proportional tubes arranged inside a large polyethylene neutron moderator, a thin Si detector for β counting and a selftriggering digital data acquisition system. The use of delayed-neutron precursors with different neutron emis...

  4. Characterization of a neutron-beta counting system with beta-delayed neutron emitters

    OpenAIRE

    Agramunt Ros, Jorge; Taín, J. L.; Gómez Hornillos, María Belén; Calviño Tavares, Francisco; Cortés Rossell, Guillem Pere; Pretel Sánchez, Carme; Riego Pérez, Albert; Tarifeño Saldivia, Ariel Esteban

    2016-01-01

    A new detection system for the measurement of beta-delayed neutron emission probabilities has been characterized using fission products with well known ß-delayed neutron emission properties. The setup consists of BELEN-20, a 4p neutron counter with twenty 3He proportional tubes arranged inside a large polyethylene neutron moderator, a thin Si detector for ß counting and a self-triggering digital data acquisition system. The use of delayed-neutron precursors with different neutron emission win...

  5. Beta-limiting Instabilities and Global Mode Stabilization in NSTX

    Science.gov (United States)

    Sabbagh, Steven

    2001-10-01

    Low aspect ratio and high edge q theoretically alter the plasma stability and mode structure compared to standard tokamak configurations. Below the no-wall limit, stability calculations with PEST, GATO, and DCON show the perturbed radial field is maximized near the center column and DCON and VALEN calculations show that mode stability is not greatly improved by a nearby conducting wall due to the short poloidal wavelength in this region. In contrast, as beta reaches and exceeds the no-wall limit, the mode becomes strongly ballooning with long poloidal wavelength at large major radius and is highly wall stabilized. In this way, wall stabilization is more effective at higher beta in low aspect ratio geometry. Research on the stability of spherical torus plasmas at and above the no-wall beta limit is being addressed on NSTX, which has produced low aspect ratio plasmas, R/a = 1.27 at plasma current up to 1.4 MA with high energy confinement (TauE/TauE-ITER89P = 2). Toroidal and normalized beta have reached 22%, and 4.3, respectively in q = 7 plasmas. The beta limit is observed to increase with increasing plasma internal inductance, li, and the stability factor betaN/li has reached 5.8, limited by sudden beta collapses at low li that was achieved by use of high-harmonic fast wave heating (HHFW). DCON stability analysis of equilibria reconstructed with EFIT using external magnetics show that the plasmas are below or at the no-wall beta limit for the n = 1 mode, which has characteristics of a current-driven kink. With more peaked current profiles (li greater than 0.7), core MHD instabilities are observed which saturate or slowly degrade beta. Sawteeth with large inversion radii can also cause substantial beta collapses, although current profile modification using HHFW, altered plasma growth, and increased toroidal field have each been successful in mitigating this effect.

  6. Beta adrenoreceptors in the rabbit bladder detrusor muscle

    International Nuclear Information System (INIS)

    This study examines the beta adrenergic receptors of the rabbit detrusor smooth muscle, employing [125I]iodocyanopindolol (ICYP) as a ligand for the binding of beta adrenergic receptors. Saturation binding experiments on the isolated membrane fraction yielded a KD for ICYP of 14.7 pM and a maximum binding of 147.6 fmol/mg of protein. Displacement of labeled ICYP by a series of beta adrenergic agents yielded the following KD values for the combined high and low affinity binding sites: I-propranolol, 0.76 nM; ICI 118,551, 1.7 nM; zinterol, 38.0 nM; metoprolol, 3.5 microM; and practolol, 61.4 microM. When these displacement experimental results were compared to KD values from other reported binding studies with ICYP for beta adrenoreceptors, both the order of potency and the KD values indicated primarily beta-2 adrenergic receptor subtypes. Computer program Scatfit analysis of the displacement curves indicated a single slope and affinity constant for all five beta adrenergic agents. Hofstee plots for zinterol, ICI 118,551 and metoprolol, however, were not linear and indicated that minor populations of beta-1 adrenoreceptors were also present as both high and low affinity binding sites could be defined. It is concluded that the primary receptor population is beta-2 and that this tissue is heterogenous with a small population of beta-1 adrenoreceptors representing approximately 13 to 23% of the total beta adrenoreceptor population

  7. Beta adrenoreceptors in the rabbit bladder detrusor muscle

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, G.F.; Marks, B.H.

    1984-02-01

    This study examines the beta adrenergic receptors of the rabbit detrusor smooth muscle, employing (/sup 125/I)iodocyanopindolol (ICYP) as a ligand for the binding of beta adrenergic receptors. Saturation binding experiments on the isolated membrane fraction yielded a KD for ICYP of 14.7 pM and a maximum binding of 147.6 fmol/mg of protein. Displacement of labeled ICYP by a series of beta adrenergic agents yielded the following KD values for the combined high and low affinity binding sites: I-propranolol, 0.76 nM; ICI 118,551, 1.7 nM; zinterol, 38.0 nM; metoprolol, 3.5 microM; and practolol, 61.4 microM. When these displacement experimental results were compared to KD values from other reported binding studies with ICYP for beta adrenoreceptors, both the order of potency and the KD values indicated primarily beta-2 adrenergic receptor subtypes. Computer program Scatfit analysis of the displacement curves indicated a single slope and affinity constant for all five beta adrenergic agents. Hofstee plots for zinterol, ICI 118,551 and metoprolol, however, were not linear and indicated that minor populations of beta-1 adrenoreceptors were also present as both high and low affinity binding sites could be defined. It is concluded that the primary receptor population is beta-2 and that this tissue is heterogenous with a small population of beta-1 adrenoreceptors representing approximately 13 to 23% of the total beta adrenoreceptor population.

  8. Proteomic analysis of transducin beta-subunit structural heterogeneity.

    Science.gov (United States)

    Clack, James W; Juhl, Martha; Rice, Carol A; Li, Junyu; Witzmann, Frank A

    2003-10-01

    Partially purified transducin was resolved using two-dimensional gel electrophoresis (2-DE). Peptide mass fingerprinting of several different spots believed to correspond to the 37 kDa beta-subunit of transducin (T(beta)) was performed. Spots were excised and proteolyzed using modified trypsin. Matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS) was performed on the peptide mixture resulting from each spot. As many as six spots with different pI, ranging from 5.2 to 6.1, were observed when separated using 2-DE. MALDI peptide mass fingerprinting determined with high probability that all of the spots were the same gene product, guanine nucleotide-binding protein G(I)/G(S)/G(T) beta-subunit 1 (GNB1; T(beta1)). This suggested that post-translational modification was responsible for the differences in pI. Phosphorylation experiments showed that at least one T(beta1) spot was phosphorylated in vitro with [gamma-(32)P]ATP by an endogenous kinase. Treatment of T(beta) with alkaline phosphatase caused a large change in the spot pattern of T(beta), suggesting that phosphorylated T(beta) is a substrate for alkaline phosphatase. We conclude that T(beta1) constitutes over 99% of the T(beta) expressed in bovine rod outer segments and displays structural heterogeneity that is due to post-translational modification. We also conclude that some, but not all, of the heterogeneity observed is due to phosphorylation of Tb1. PMID:14595696

  9. Use of beta blockers in various clinical states

    Directory of Open Access Journals (Sweden)

    Radović Vesna V.

    2011-01-01

    Full Text Available Introduction. According to the convincing evidence, a decline in mortality rate has been achieved with beta-blockers in patients with an acute myocardial infarction and in post-infarction follow-up. In fact, there has been a clear reduction of sudden coronary death. The necessary condition for the efficiency of beta-blockers is an early use. They are also a medication of choice for angina after an infarction. The objective of this work was to evaluate the use of beta-blockers after a myocardial infarction in various clinical states and to eliminate doubts concerning their prescription. Beta blockers Even in conditions considered contraindications for administration of beta blockers such as old age, diabetes, non-Q-wave myocardial infarction, peripheral vascular disease, arterial disease, heart insufficiency, ventricular arrhythmias, renal disease, chronic obstructive pulmonary disease, asthma and depression, patients benefit from beta blockers when they are given along with a right choice of the medication and a regular follow-up of the patient. Preference is given to cardioselective beta blockers in patients with diabetes or lung disease. Beta-blockers do not cause long-term lipid alterations. Therefore, the matter of clinically significant alterations of lipids or blood glucose levels should not need further consideration as a problem of the treatment of diabetics. Discussion and conclusion. Investigations have proved that the use of beta-blockers reduces the development of cerebrovascular accidents, heart insufficiency and hypertension. Despite strong arguments and numerous recommendations, beta-blockers have not been accepted to a sufficient extent as an integral part of treatment of acute coronary syndrome and related diseases, to the detriment of many lost lives and in spite of favourable pharmaco-economic aspect.

  10. Hemoglobin Neapolis, beta 126(H4)Val----Gly: a novel beta-chain variant associated with a mild beta-thalassemia phenotype and displaying anomalous stability features.

    Science.gov (United States)

    Pagano, L; Lacerra, G; Camardella, L; De Angioletti, M; Fioretti, G; Maglione, G; de Bonis, C; Guarino, E; Viola, A; Cutolo, R

    1991-12-01

    A novel beta-chain, beta 126(H4)Val----Gly, electrophoretically silent, was detected by reverse-phase high performance liquid chromatography in three unrelated families from Naples (Southern Italy) and accounted for about 30% of the total beta-chains. The amino acid substitution was detected by HPLC fingerprint. The eight heterozygous patients showed hematologic and biosynthetic alterations of mild beta-thalassemia type. The hemoglobin variant showed abnormal stability features. It was unstable in the heat stability and isopropanol precipitation tests, but did not cause a hemolytic syndrome in vivo and was stable in a time-course experiment of biosynthesis in vitro. DNA polymerase chain reaction direct sequencing of the mutated gene from 135 nt upstream of the cap site to 106 nt downstream of the polyadenylation site showed only the beta 126 GTG----GGG mutation, which was confirmed in the other patients by allele-specific oligonucleotide hybridization. The mutation was found to be associated with a type II beta-globin framework and restriction fragment length polymorphism haplotype V. The novel variant was named hemoglobin Neapolis. PMID:1954392

  11. $\\beta$ Pictoris' inner disk in polarized light and new orbital parameters for $\\beta$ Pictoris b

    CERN Document Server

    Millar-Blanchaer, Maxwell A; Pueyo, Laurent; Kalas, Paul; Dawson, Rebekah I; Wang, Jason; Perrin, Marshall; Moon, Dae-Sik; Macintosh, Bruce; Ammons, S Mark; Barman, Travis; Cardwell, Andrew; Chen, Christine H; Chiang, Eugene; Chilcote, Jeffrey; Cotten, Tara; De Rosa, Robert J; Draper, Zachary H; Dunn, Jennifer; Duchêne, Gaspard; Esposito, Thomas M; Fitzgerald, Michael P; Follette, Katherine B; Goodsell, Stephen J; Greenbaum, Alexandra Z; Hartung, Markus; Hibon, Pascale; Hinkley, Sasha; Ingraham, Patrick; Jensen-Clem, Rebecca; Konopacky, Quinn; Larkin, James E; Long, Douglas; Maire, Jérôme; Marchis, Franck; Marley, Mark S; Marois, Christian; Morzinski, Katie M; Nielsen, Eric L; Palmer, David W; Oppenheimer, Rebecca; Poyneer, Lisa; Rajan, Abhijith; Rantakyrö, Fredrik T; Ruffio, Jean-Baptiste; Sadakuni, Naru; Saddlemyer, Leslie; Schneider, Adam C; Sivaramakrishnan, Anand; Soummer, Remi; Thomas, Sandrine; Vasisht, Gautam; Vega, David; Wallace, J Kent; Ward-Duong, Kimberly; Wiktorowicz, Sloane J; Wolff, Schuyler G

    2015-01-01

    We present $H$-band observations of $\\beta$ Pic with the Gemini Planet Imager's (GPI's) polarimetry mode that reveal the debris disk between ~0.3" (~6 AU) and ~1.7" (~33 AU), while simultaneously detecting $\\beta$ Pic $b$. The polarized disk image was fit with a dust density model combined with a Henyey-Greenstein scattering phase function. The best fit model indicates a disk inclined to the line of sight ($\\phi=85.27{\\deg}^{+0.26}_{-0.19}$) with a position angle $\\theta_{PA}=30.35{\\deg}^{+0.29}_{-0.28}$ (slightly offset from the main outer disk, $\\theta_{PA}\\approx29{\\deg}$), that extends from an inner disk radius of $23.6^{+0.9}_{-0.6}$ AU to well outside GPI's field of view. In addition, we present an updated orbit for $\\beta$ Pic $b$ based on new astrometric measurements taken in GPI's spectroscopic mode spanning 14 months. The planet has a semi-major axis of $a=9.2^{+1.5}_{-0.4}$AU, with an eccentricity $e\\leq 0.26$. The position angle of the ascending node is $\\Omega=31.75{\\deg}\\pm0.15$, offset from bot...

  12. Thermodynamics in $f(R,R_{\\alpha\\beta}R^{\\alpha\\beta},\\phi)$ theory of gravity

    CERN Document Server

    Zubair, M; Bahamonde, Sebastian

    2016-01-01

    First and second laws of black hole thermodynamics are examined at the apparent horizon of FRW spacetime in $f(R,R_{\\alpha\\beta}R^{\\alpha\\beta} ,\\phi)$ gravity, where $R$, $R_{\\alpha\\beta}$ and $\\phi$ are the Ricci scalar, Ricci invariant and the scalar field respectively. In this modified theory, Friedmann equations are formulated for any spatial curvature. These equations can be presented into the form of first law of thermodynamics $T_{h}d\\hat{S}_{h}+ T_{h}d_{i}\\hat{S}_{h}+W dV=dE$, where $d_{i}\\hat{S}_{h}$ is an extra entropy term because of the non-equilibrium presentation of the equations. The generalized second law of thermodynamics (GSLT) is expressed in an inclusive form where these results can be represented, in GR, $f(R)$ and $f(R, \\phi)$ gravities. Finally to check the validity of GSLT, we take some particular models and produce constraints of the parameters.

  13. Systematic study of the single-state dominance in 2 nu beta beta decay transitions

    CERN Document Server

    Civitarese, O

    1999-01-01

    The single-state-dominance hypothesis (SSDH) states that the decay rates of the two-neutrino double-beta decay are governed by a virtual two-step transition connecting the initial and final ground states through the first 1 sup + state, 1 sup + sub 1 , of the intermediate odd-odd nucleus, for those odd-odd nuclei where the 1 sup + sub 1 state is the ground state. To investigate the validity of the SSDH we have performed a systematical theoretical analysis of all known double-beta-decay transitions where the SSDH conditions are fulfilled. The calculations are based on the quasiparticle randon-phase approximation (QRPA) and the results have been obtained by using realistic single-particle bases and realistic interactions. We have studied the double beta sup - decays of sup 1 sup 0 sup 0 Mo, sup 1 sup 1 sup 0 Pd, sup 1 sup 1 sup 4 Cd, sup 1 sup 1 sup 6 Cd and sup 1 sup 2 sup 8 Te and the double electron-capture transitions in sup 1 sup 0 sup 6 Cd and sup 1 sup 3 sup 6 Ce. The analysis shows that the SSDH is real...

  14. Planetary companions in K giants beta Cancri, mu Leonis, and beta Ursae Minoris

    CERN Document Server

    Lee, B -C; Park, M -G; Mkrtichian, D E; Hatzes, A P; Kim, K -M

    2014-01-01

    Auns. The aim of our paper is to investigate the low-amplitude and long-period variations in evolved stars with a precise radial velocity (RV) survey. Methods. The high-resolution, the fiber-fed Bohyunsan Observatory Echelle Spectrograph (BOES) was used from 2003 to 2013 for a radial velocity survey of giant stars as part of the exoplanet search program at Bohyunsan Optical Astronomy Observatory (BOAO). Results. We report the detection of three new planetary companions orbiting the K giants beta Cnc, mu Leo, and beta UMi. The planetary nature of the radial velocity variations is supported by analyzes of ancillary data. The HIPPARCOS photometry shows no variations with periods close to those in RV variations and there is no strong correlation between the bisector velocity span (BVS) and the radial velocities for each star. Furthermore, the stars show weak or no core reversal in Ca II H lines indicating that they are inactive stars. The companion to beta Cnc has a minimum mass of 7.8 M_Jup in a 605-day orbit wi...

  15. Structure of beta-diketiminates and beta-aminoketones made from anisidines or chloroanilines: tin and lithium complexes

    Czech Academy of Sciences Publication Activity Database

    Olejník, R.; Padělková, Z.; Horáček, Michal; Růžička, A.

    2012-01-01

    Roč. 35, 1-2 (2012), s. 13-27. ISSN 0334-7575 Institutional support: RVO:61388955 Keywords : beta-diketimines * beta-enaminones * lithium Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 0.207, year: 2011

  16. In vitro activities of 15 oral beta-lactams against Klebsiella pneumoniae harboring new extended-spectrum beta-lactamases.

    OpenAIRE

    Kitzis, M D; Liassine, N; Ferré, B.; Gutmann, L; Acar, J F; Goldstein, F.

    1990-01-01

    The activities of 15 oral beta-lactams against Klebsiella pneumoniae harboring new extended-spectrum beta-lactamases were studied. All compounds were affected by these enzymes, especially by the SHV derivatives. Except for ceftibuten, the compounds with the greatest intrinsic activity were more affected by the presence of these enzymes than were older compounds with moderate intrinsic activity.

  17. Beta-Lactamase Inhibitory Potential and Antibacterial Potentiation of Certain Medicinal Plants and Extracts against Extended Spectrum Beta-Lactamase Producers

    OpenAIRE

    Selvanayagam M; Shakti Singh Solanki

    2013-01-01

    Beta-lactamase inhibitory potential of fifteen plants was checked by beta-lactamase enzyme inhibition assay wherein inhibition of commercial beta-lactamase by their extracts was determined using a chromogenic substrate. These plant extracts showed considerable beta-lactamase inhibition. All these plant extracts were further checked for their inhibition of Extended Spectrum Beta-lactamase in the screening assay. Eight of the plant extracts showed potentiation of cephalosporins against the Exte...

  18. Characterization of recombinant RI beta and evaluation of the presence of RI beta protein in rat brain and testicular extracts.

    Science.gov (United States)

    DeManno, D A; Jackiw, V; Brooks, E; Hunzicker-Dunn, M

    1994-07-21

    Based upon recent reports that the mRNA from the regulatory (R) RI beta subunit of cAMP-dependent protein kinase (PKA) was expressed in testicular extracts, we determined whether testicular extracts exhibited RI beta protein. To accomplish this goal, we initially determined the fundamental labeling and ionic characteristics of recombinant RI beta. Recombinant RI beta eluted from DEAE-cellulose with a salt concentration (of 0.075 M) equivalent to its elution position from soluble mouse brain extracts with catalytic subunit-free RI alpha. As predicted by its amino acid sequence homology to RI alpha, recombinant RI beta was not phosphorylated by PKA but was labeled specifically with 8-azido-adenosine 3':5'-[32P]monophosphate (8-N3[32P]cAMP). Additionally, RI antisera reacted equally with RI alpha (47 kDa) and recombinant RI beta (53 kDa). However, recombinant RI beta exhibited an unexpectedly basic pI of 6.65-6.85. By using a pH gradient for isoelectric focussing that allowed for clear focussing of 8-N3[32P]cAMP-labeled recombinant RI beta, 8-N3[32P]cAMP-labeled RI beta was readily detected by two-dimensional gel electrophoresis in rat brain particulate extracts and exhibited a pI equivalent to that of recombinant RI beta. The 53-kDa RI beta was undetectable either by its immunoreactivity or upon photoaffinity labeling with 8-N3[32P]cAMP by one or two-dimensional gel electrophoresis in soluble or particulate extracts of testes of 14-day-old, 45-day-old, or adult rats or in epididymal sperm. However, 8-N3[32P]cAMP-labeled RI beta was detected, albeit in very small levels, by two-dimensional electrophoresis upon separation of PKAs in testes of 14-day-old rats by DEAE-cellulose chromatography but was absent in equivalent extracts from adult rat testes. These results demonstrate that the unexpectedly basic pI of RI beta allows for its clear separation by two-dimensional electrophoresis from the RII proteins and therefore allows for its unambiguous identification. Further

  19. Interactions between beta subunits of the KCNMB family and Slo3: beta4 selectively modulates Slo3 expression and function.

    Directory of Open Access Journals (Sweden)

    Cheng-Tao Yang

    Full Text Available BACKGROUND: The pH and voltage-regulated Slo3 K(+ channel, a homologue of the Ca(2+- and voltage-regulated Slo1 K(+ channel, is thought to be primarily expressed in sperm, but the properties of Slo3 studied in heterologous systems differ somewhat from the native sperm KSper pH-regulated current. There is the possibility that critical partners that regulate Slo3 function remain unidentified. The extensive amino acid identity between Slo3 and Slo1 suggests that auxiliary beta subunits regulating Slo1 channels might coassemble with and modulate Slo3 channels. Four distinct beta subunits composing the KCNMB family are known to regulate the function and expression of Slo1 Channels. METHODOLOGY/PRINCIPAL FINDINGS: To examine the ability of the KCNMB family of auxiliary beta subunits to regulate Slo3 function, we co-expressed Slo3 and each beta subunit in heterologous expression systems and investigated the functional consequences by electrophysiological and biochemical analyses. The beta4 subunit produced an 8-10 fold enhancement of Slo3 current expression in Xenopus oocytes and a similar enhancement of Slo3 surface expression as monitored by YFP-tagged Slo3 or biotin labeled Slo3. Neither beta1, beta2, nor beta3 mimicked the ability of beta4 to increase surface expression, although biochemical tests suggested that all four beta subunits are competent to coassemble with Slo3. Fluorescence microscopy from beta4 KO mice, in which an eGFP tag replaced the deleted exon, revealed that beta4 gene promoter is active in spermatocytes. Furthermore, quantitative RT-PCR demonstrated that beta4 and Slo3 exhibit comparable mRNA abundance in both testes and sperm. CONCLUSIONS/SIGNIFICANCE: These results argue that, for native mouse Slo3 channels, the beta4 subunit must be considered as a potential interaction partner and, furthermore, that KCNMB subunits may have functions unrelated to regulation of the Slo1 alpha subunit.

  20. Adverse effects of beta-agonists: are they clinically relevant?

    Science.gov (United States)

    Abramson, Michael J; Walters, Julia; Walters, E Haydn

    2003-01-01

    Inhaled beta(2)-adrenoceptor agonists (beta(2)-agonists) are the most commonly used asthma medications in many Western countries. Minor adverse effects such as palpitations, tremor, headache and metabolic effects are predictable and dose related. Time series studies suggested an association between the relatively nonselective beta-agonist fenoterol and asthma deaths. Three case-control studies confirmed that among patients prescribed fenoterol, the risk of death was significantly elevated even after controlling for the severity of asthma. The Saskatchewan study not only found an increased risk of death among patients dispensed fenoterol, but also suggested this might be a class effect of beta(2)-agonists. However, in subsequent studies, the long-acting beta(2)-agonist salmeterol was not associated with increased asthma mortality. In a case-control study blood albuterol (salbutamol) concentrations were found to be 2.5 times higher among patients who died of asthma compared with controls. It is speculated that such toxic concentrations could cause tachyarrhythmias under conditions of hypoxia and hypokalemia. The risk of asthma exacerbations and near-fatal attacks may also be increased among patients dispensed fenoterol, but this association may be largely due to confounding by severity. Although salmeterol does not appear to increase the risk of near-fatal attacks, there is a consistent association with the use of nebulized beta(2)-agonists. Nebulized and oral beta(2)-agonists are also associated with an increased risk of cardiovascular death, ischemic heart disease and cardiac failure. Caution should be exercised when first prescribing a beta-agonist for patients with cardiovascular disease. A potential mechanism for adverse effects with regular use of beta(2)-agonists is tachyphylaxis. Tachyphylaxis to the bronchodilator effects of long-acting beta(2)-agonists can occur, but has been consistently demonstrated only for formoterol (eformoterol) a full agonist, rather

  1. Characterization of the inclusion complex ropivacaine: {beta}-cyclodextrin; Caracterizacao do complexo de inclusso ropivacaina: {beta}-ciclodextrina

    Energy Technology Data Exchange (ETDEWEB)

    Fraceto, Leonardo Fernandes [Universidade Estadual Paulista Julio de Mesquita Filho, Sorocaba, SP (Brazil). Dept. de Engenharia Ambiental]. E-mail: leonardo@sorocaba.unesp.br; Goncalves, Marcos Moises [Universidade de Sorocaba, SP (Brazil); Moraes, Carolina Morales; Araujo, Daniele Ribeiro de; Zanella, Luciana; Paula, Eneida de [Universidade Estadual de Campinas (UNICAMP), Campinas, SP (Brazil). Inst. de Biologia. Dept. de Bioquimica; Pertinhez, Thelma de Aguiar [Universidade de Parma (Italy). Dept. de Medicina Experimental

    2007-09-15

    Ropivacaine (RVC) is a widely used local anesthetic. The complexation of RVC with {beta}-cyclodextrin ({beta}-CD) is of great interest for the development of more efficient local anesthetic formulations. The present work focuses on the characterization of the RVC:{beta}-CD complex by nuclear magnetic resonance (NMR). The stoichiometry of the complex is 1:2 RVC:{beta}-CD. DOSY-NMR shows that the association constant is 55.5 M{sup -1}. Longitudinal relaxation time results show that RVC changes its mobility in the presence of {beta}-CD. This study is focused on the physicochemical characterization of inclusion complexes that are potentials options for pain treatment. (author)

  2. Strain-dependent differences in sensitivity of rat beta-cells to interleukin 1 beta in vitro and in vivo

    DEFF Research Database (Denmark)

    Reimers, J I; Andersen, H U; Mauricio, D;

    1996-01-01

    The aim of this study was to investigate whether strain-dependent differences in beta-cell sensitivity to interleukin (IL) 1 beta exist in vitro and in vivo and if so, whether these differences correlate to variations in IL-1 beta-induced islet inducible nitric oxide synthase (iNOS) mRNA expression....../CR) rats were resistant. Furthermore, IL-1 beta induced higher islet iNOS mRNA expression and nitric oxide production from WK/Mol islets compared with BN/CR islets. WK/Mol, WK/CR, BN/Mol, BN/CR, and Lewis-Scripps/Mol (LS/Mol) rats received one daily injection of recombinant human IL-1 beta (4.0 microg...

  3. Properties of beta-galactosidase III: implications for entry of galactosides into Klebsiella.

    OpenAIRE

    Hall, B G

    1980-01-01

    Klebsiella sp. strain CT-200 lacks both its plasmid-borne lac operon, which specifies beta-galactosidase I, and its chromosomal lac operon, which specifies beta-galactosidase II, but it expresses a gene for a third beta-galactosidase, beta-galactosidase III, constitutively. CT-200 was examined to determine whether there was a beta-galactoside permease associated with the beta-galactosidase III gene. The failure of CT-200 to transport thiomethyl-beta-galactoside, o-nitrophenyl-beta-D-galactopy...

  4. Histologic examination of the rat central nervous system after intrathecal administration of human beta-endorphin

    DEFF Research Database (Denmark)

    Hée, P.; Klinken, Leif; Ballegaard, Martin

    1992-01-01

    Neuropathology, analgesics - intrathecal, central nervous system, histology, human beta-endorphin, toxicity......Neuropathology, analgesics - intrathecal, central nervous system, histology, human beta-endorphin, toxicity...

  5. A new disease? Persistent isolated beta.hydroxybutyrate ketosis and mild congenital hyperinsulinism

    DEFF Research Database (Denmark)

    Christesen, Henrik Thybo; Brusgaard, Klaus; Ditkovskaya, L;

    A new disease? Persistent isolated beta.hydroxybutyrate ketosis and mild congenital hyperinsulinism.......A new disease? Persistent isolated beta.hydroxybutyrate ketosis and mild congenital hyperinsulinism....

  6. High harmonic fast waves in high beta plasmas

    International Nuclear Information System (INIS)

    High harmonic fast magnetosonic wave in high beta/high dielectric plasmas is investigated. including the finite-Larmor-radius effects. In this regime, due to the combination of group velocity slow down and the high beta enhancement, the electron absorption via electron Landau and electron magnetic pumping becomes significant enough that one can expect a strong (∼ 100%) single pass absorption. By controlling the wave spectrum, the prospect of some localized electron heating and current drive appears to be feasible in high beta low-aspect-ratio tokamak regimes. Inclusion of finite-Larmor-radius terms shows an accessibility limit in the high ion beta regime (βi = 50% for a deuterium plasma) due to mode-conversion into an ion Bernstein-wave-like mode while no beta limit is expected for electrons. With increasing ion beta, the ion damping can increase significantly particularly near the beta limits. The presence of energetic ion component expected during intense NBI and α-heating does not appear to modify the accessibility condition nor cause excessive wave absorption

  7. Calculation of {beta}-ray spectra. Odd-odd nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Tachibana, Takahiro [Waseda Univ., Tokyo (Japan). Advanced Research Center for Science and Engineering

    1996-05-01

    In order to study {beta}-ray of atomic nucleus, it is natural to consider {beta}-ray data fundamental and important. In a recent experiment, Rudstam measured {beta}-ray spectra from short term nuclear fission product species in 1990. It is an important check point in theoretical study on {beta}-ray to investigate if these experimental data can be reproduced by any theoretical calculation. As there are several spectrum studies of {beta}-ray through decay heat for its various properties due to the general theory of the {beta}-decay, little descriptions can be found. In even such studies, spectra under high excitation state of daughter species difficult to measure and apt to short experimental results were treated with combination spectra composed of experimental and calculated values such as substitution of a part of the general theory with calculated value. In this paper, the {beta} spectra supposed by only the general theory was reported without using such data combination in order to confirm effectiveness of the theory. In particular, this report was described mainly on the results using recent modification of odd-odd nucleus species. (G.K.)

  8. Cohesin SMC1beta protects telomeres in meiocytes.

    Science.gov (United States)

    Adelfalk, Caroline; Janschek, Johannes; Revenkova, Ekaterina; Blei, Cornelia; Liebe, Bodo; Göb, Eva; Alsheimer, Manfred; Benavente, Ricardo; de Boer, Esther; Novak, Ivana; Höög, Christer; Scherthan, Harry; Jessberger, Rolf

    2009-10-19

    Meiosis-specific mammalian cohesin SMC1beta is required for complete sister chromatid cohesion and proper axes/loop structure of axial elements (AEs) and synaptonemal complexes (SCs). During prophase I, telomeres attach to the nuclear envelope (NE), but in Smc1beta(-/-) meiocytes, one fifth of their telomeres fail to attach. This study reveals that SMC1beta serves a specific role at telomeres, which is independent of its role in determining AE/SC length and loop extension. SMC1beta is necessary to prevent telomere shortening, and SMC3, present in all known cohesin complexes, properly localizes to telomeres only if SMC1beta is present. Very prominently, telomeres in Smc1beta(-/-) spermatocytes and oocytes loose their structural integrity and suffer a range of abnormalities. These include disconnection from SCs and formation of large telomeric protein-DNA extensions, extended telomere bridges between SCs, ring-like chromosomes, intrachromosomal telomeric repeats, and a reduction of SUN1 foci in the NE. We suggest that a telomere structure protected from DNA rearrangements depends on SMC1beta. PMID:19841137

  9. Synthesis of beta carbon nitride nanosized crystal through mechanochemical reaction

    CERN Document Server

    Yin Long Wei; Liu Yu Xian; Sui Jin Ling; Wang Jing Min

    2003-01-01

    Nanosized beta carbon nitride (beta-C sub 3 N sub 4), of grain size several tens of nanometres, has been synthesized by mechanochemical reaction processing. The low-cost synthetic method developed facilitates the novel and effective synthesis of nanosized crystalline beta-C sub 3 N sub 4 (a = 6.36 A, c = 4.648 A) powders. The graphite powders were first milled to a nanoscale state, then the nanosized graphite powders were milled in an atmosphere of NH sub 3 gas. It was found that nanosized beta-C sub 3 N sub 4 was formed after high-energy ball milling under an NH sub 3 atmosphere. After thermal annealing, the shape of the beta-C sub 3 N sub 4 changes from flake-like to sphere-like. The nanosized beta-C sub 3 N sub 4 formed was characterized by x-ray diffraction, Fourier transformation infrared spectroscopy, and transmission electron microscopy. A solid-gas reaction mechanism was proposed for the formation of nanosized beta-C sub 3 N sub 4 at room temperature induced by mechanochemical activation.

  10. Targeting insulin-producing beta cells for regenerative therapy.

    Science.gov (United States)

    Migliorini, Adriana; Roscioni, Sara S; Lickert, Heiko

    2016-09-01

    Pancreatic beta cells differ in terms of glucose responsiveness, insulin secretion and proliferative capacity; however, the molecular pathways that regulate this cellular heterogeneity are unknown. We have identified the Wnt-planar cell polarity (PCP) effector Flattop (FLTP) as a biomarker that identifies mature beta cells in the islets of Langerhans. Interestingly, three-dimensional architecture and Wnt-PCP ligands are sufficient to trigger mouse and human beta cell maturation. These results highlight the fact that novel biomarkers shed light on the long-standing mystery of beta cell heterogeneity and identify the Wnt-PCP pathway as triggering beta cell maturation. Understanding heterogeneity in the islets of Langerhans might allow targeting of beta cell subpopulations for regenerative therapy and provide building principles for stem cell-derived islets. This review summarises a presentation given at the 'Can we make a better beta cell?' symposium at the 2015 annual meeting of the EASD. It is accompanied by two other reviews on topics from this symposium (by Amin Ardestani and Kathrin Maedler, DOI: 10.1007/s00125-016-3892-9 , and by Harry Heimberg and colleagues, DOI: 10.1007/s00125-016-3879-6 ) and a commentary by the Session Chair, Shanta Persaud (DOI: 10.1007/s00125-016-3870-2 ). PMID:27412250

  11. Insulin signaling regulates mitochondrial function in pancreatic beta-cells.

    Directory of Open Access Journals (Sweden)

    Siming Liu

    Full Text Available Insulin/IGF-I signaling regulates the metabolism of most mammalian tissues including pancreatic islets. To dissect the mechanisms linking insulin signaling with mitochondrial function, we first identified a mitochondria-tethering complex in beta-cells that included glucokinase (GK, and the pro-apoptotic protein, BAD(S. Mitochondria isolated from beta-cells derived from beta-cell specific insulin receptor knockout (betaIRKO mice exhibited reduced BAD(S, GK and protein kinase A in the complex, and attenuated function. Similar alterations were evident in islets from patients with type 2 diabetes. Decreased mitochondrial GK activity in betaIRKOs could be explained, in part, by reduced expression and altered phosphorylation of BAD(S. The elevated phosphorylation of p70S6K and JNK1 was likely due to compensatory increase in IGF-1 receptor expression. Re-expression of insulin receptors in betaIRKO cells partially restored the stoichiometry of the complex and mitochondrial function. These data indicate that insulin signaling regulates mitochondrial function and have implications for beta-cell dysfunction in type 2 diabetes.

  12. Affinity and selectivity of beta-adrenoceptor antagonists in vitro

    International Nuclear Information System (INIS)

    The potency order of the catecholamines (-)-isoprenaline (Iso), (-)-noradrenaline (NA), and (-)-adrenaline (Adr) in competition for radiolabelled sites is used for their pharmacological classification. It is shown that the radioligand 3H-CGP 12177 exclusively labels beta 1-adrenoceptors in rat salivary gland membranes (Iso greater than NA greater than Adr), and beta 2-adrenoceptors in rat reticulocytes (Iso greater than Adr greater than or equal to NA). These models are then used to derive the subtype-selectivity of the classical beta-adrenoceptor antagonists (+/-)-propranolol (prop; twofold beta 2-selective) and (+/-)-atenolol (aten; 35-fold beta 1-selective), as well as of the newer antagonists (+/-)-betaxolol and (+/-)-bisoprolol (betax and biso; 35-fold and 75-fold beta 1-selective, respectively). The ligand with the highest selectivity is ICI 118,551 (ICI), with a 300-fold beta 2-subtype selectivity. For comparison with antagonistic effects in humans at given plasma concentrations, the equilibrium dissociation constants of the ligands are measured in the presence of native human plasma and yield values for the relative selectively labelled subtype in the mean (Ki-values in nmol/l): prop: 20, aten: 250, biso: 24, betax: 23, and ICI: 2.5

  13. IN-SITU TRITIUM BETA DETECTOR

    International Nuclear Information System (INIS)

    The objectives of this three-phase project were to design, develop, and demonstrate a monitoring system capable of detecting and quantifying tritium in situ in ground and surface waters, and in water from effluent lines prior to discharge into public waterways. The tritium detection system design is based on measurement of the low energy beta radiation from the radioactive decay of tritium using a special form of scintillating optical fiber directly in contact with the water to be measured. The system consists of the immersible sensor module containing the optical fiber, and an electronics package, connected by an umbilical cable. The system can be permanently installed for routine water monitoring in wells or process or effluent lines, or can be moved from one location to another for survey use. The electronics will read out tritium activity directly in units of pico Curies per liter, with straightforward calibration. In Phase 1 of the project, we characterized the sensitivity of fluor-doped plastic optical fiber to tritium beta radiation. In addition, we characterized the performance of photomultiplier tubes needed for the system. In parallel with this work, we defined the functional requirements, target specifications, and system configuration for an in situ tritium beta detector that would use the fluor-doped fibers as primary sensors of tritium concentration in water. The major conclusions from the characterization work are: A polystyrene optical fiber with fluor dopant concentration of 2% gave best performance. This fiber had the highest dopant concentration of any fibers tested. Stability may be a problem. The fibers exposed to a 22-day soak in 120 F water experienced a 10x reduction in sensitivity. It is not known whether this was due to the build up of a deposit (a potentially reversible effect) or an irreversible process such as leaching of the scintillating dye. Based on the results achieved, it is premature to initiate Phase 2 and commit to a prototype

  14. Power output and efficiency of beta-emitting microspheres

    International Nuclear Information System (INIS)

    Current standard methods to calculate the dose of radiation emitted during medical applications by beta-minus emitting microspheres rely on an over-simplistic formalism. This formalism is a function of the average activity of the radioisotope used and the physiological dimensions of the patient only. It neglects the variation in energy of the emitted beta particle due to self-attenuation, or self-absorption, effects related to the finite size of the sphere. Here it is assumed the sphere is comprised of a pure radioisotope with beta particles being emitted isotropically throughout the material. The full initial possible kinetic energy distribution of a beta particle is taken into account as well as the energy losses due to scattering by other atoms in the microsphere and bremsstrahlung radiation. By combining Longmire’s theory of the mean forward range of charged particles and the Rayleigh distribution to take into account the statistical nature of scattering and energy straggling, the linear attenuation, or self-absorption, coefficient for beta-emitting radioisotopes has been deduced. By analogy with gamma radiation transport in spheres, this result was used to calculate the rate of energy emitted by a beta-emitting microsphere and its efficiency. Comparisons to standard point dose kernel formulations generated using Monte Carlo data show the efficacy of the proposed method. Yttrium-90 is used as a specific example throughout, as a medically significant radioisotope, frequently used in radiation therapy for treating cancer. - Highlights: • Range-energy relationship for the beta particles in yttrium-90 is calculated. • Formalism for the semi-analytical calculation of self-absorption coefficients. • Energy-dependent self-absorption coefficient calculated for yttrium-90. • Flux rate of beta particles from a self-attenuating radioactive sphere is shown. • The efficiency of beta particle emitting radioactive microspheres is calculated

  15. The molecular organization of the beta-sheet region in Corneous beta-proteins (beta-keratins) of sauropsids explains its stability and polymerization into filaments.

    Science.gov (United States)

    Calvaresi, Matteo; Eckhart, Leopold; Alibardi, Lorenzo

    2016-06-01

    The hard corneous material of avian and reptilian scales, claws, beak and feathers is mainly derived from the presence of proteins formerly known as beta-keratins but now termed Corneous beta-proteins of sauropsids to distinguish them from keratins, which are members of the intermediate filament protein family. The modeling of the conserved 34 amino acid residues long central beta-sheet region of Corneous beta-proteins using an ab initio protein folding and structure prediction algorithm indicates that this region is formed by four antiparallel beta-sheets. Molecular dynamic simulations and Molecular Mechanics/Poisson Boltzmann Surface Area (MM-PBSA) analysis showed that the disposition of polar and apolar amino acids within the beta-region gives rise to an amphipathic core whose stability is further increased, especially in an aqueous environment, by the association into a dimer due to apolar interactions and specific amino-acid interactions. The dimers in turn polymerize into a 3nm thick linear beta-filament due to van der Waals and hydrogen-bond interactions. It is suggested that once this nuclear core of anti-parallel sheets evolved in the genome of a reptilian ancestor of the extant reptiles and birds about 300 millions years ago, new properties emerged in the corneous material forming scales, claws, beaks and feathers in these amniotes based on the tendency of these unique corneous proteins to form stable filaments different from keratin intermediate filaments or sterical structures formed by other corneous proteins so far known. PMID:26965557

  16. Study of 193Os beta- decay

    International Nuclear Information System (INIS)

    In this work, the excited levels of 193Ir populated by the beta- decay of 193Os (T1/2 ∼ 30h) were investigated. For that purpose, ∼ 5 mg samples of 99%-enriched 192Os were irradiated under a thermal neutron flux of ∼ 1012 s-1 and then analysed both using single gamma spectroscopy and a 4-detector multi parametric acquisition facility, which provided data for both a gamma gamma coincidence analysis and a directional angular correlation gamma gamma (θ ) study. From these data, 28 transitions were added to this decay scheme, 11 of which were previously known from nuclear reactions and 17 observed for the first time. Eight excited levels were also added to the decay scheme, 3 of which were known from nuclear reaction studies - the remaining 5 are suggested for the first time. Moreover, it was possible to confirm suspicions found in reference that the levels at 848.93 keV and 849.093 keV are indeed the same; it was also possible to confirm the existence of an excited level at 806.9 keV, which had been inferred, but not experimentally confirmed in beta decay studies to date. The angular correlation analysis allowed for the definition of the spin of the excited level at 874 keV as 5/2+; moreover, the results showed a 79% probability that the spin of the 1078 keV level is 5/2/'-, and also restricted the spin possibilities for the new excited level at 960 keV to two values (1/2 or 3/2). It was also possible to measure the multipolarity mixing ratio (δLn+1/Ln) for 43 transitions - 19 of them for the first time and most of the others with a better precision than previously known. Finally, an attempt was made to understand the low-lying levels structure for this nucleus using a theoretical model, which reproduced the ground state and the two lowest-lying excited levels in 193Ir. (author)

  17. Double beta decay of 128Te and RIS

    International Nuclear Information System (INIS)

    The paper considers the use of Resonance Ionization Spectroscopy (RIS) in the determination of the electron neutrino mass via the double beta decay of 128Te. An outline is given of the theoretical background to the electron neutrino restmass, and the importance of the neutrino properties in Grand Unification Theories. The detection method for double beta decay is described; the discussion is restricted to tellurium ores and the decays 128Te → 128Xe, and 130Te → 130Xe. A consideration of existing data on double beta decay of 128Te indicates that most aspects of the detection could benefit from RIS. (U.K.)

  18. Use of beta blockers in various clinical states

    OpenAIRE

    Radović Vesna V.

    2011-01-01

    Introduction. According to the convincing evidence, a decline in mortality rate has been achieved with beta-blockers in patients with an acute myocardial infarction and in post-infarction follow-up. In fact, there has been a clear reduction of sudden coronary death. The necessary condition for the efficiency of beta-blockers is an early use. They are also a medication of choice for angina after an infarction. The objective of this work was to evaluate the use of beta-blockers after a my...

  19. Atualizações sobre beta-hidroxi-beta-metilbutirato: suplementação e efeitos sobre o catabolismo de proteínas New findings on beta-hydroxy-beta-methylbutyirate: supplementation and effects on the protein catabolism

    Directory of Open Access Journals (Sweden)

    Everson Araújo Nunes

    2008-04-01

    Full Text Available O beta-hidroxi-beta-metilbutirato, metabólito do aminoácido leucina, vem sendo utilizado como suplemento alimentar, em situações específicas, com o intuito de aumentar ou manter a massa isenta de gordura. Os relatos dos efeitos do beta-hidroxi-beta-metilbutirato em estudos recentes fizeram crescer as expectativas sobre sua utilização em casos patológicos. Também foram demonstrados melhores resultados, quando da sua ingestão, no treinamento de força em indivíduos iniciantes e em idosos. Em humanos o beta-hidroxi-beta-metilbutirato tem sido usado como agente anti-catabólico, e em modelos animais foi demonstrado ser eficaz em inibir a atividade de vias proteolíticas em células musculares de indivíduos caquéticos in vitro e in vivo. Os mecanismos participantes desses processos envolvem: a inibição da atividade do sistema ubiquitina proteossoma ATP-dependente, a inibição de vias de sinalização com participação da proteína quinase C-alfa e a diminuição da concentração citoplasmática do fator nuclear - kappa B livre, eventos relacionados ao decréscimo da proteólise em células musculares.The leucine metabolite beta-hydroxy-beta-methylbutyrate has been used as a nutritional supplement in specific situations to prevent losing or to increase lean mass. Recent studies showed interesting results of beta-hydroxy-beta-methylbutyrate supplementation in certain disease states. Better results have also been demonstrated when it is taken by starters or old individuals doing strength training. In humans, beta-hydroxy-beta-methylbutyrate has been used as an anticatabolic agent and in animal models it has been demonstrated to be effective in inhibiting the activity of the proteolytic pathways in muscle cells of extremely weak individuals in vivo and in vitro. The mechanisms that participate in this process involve: inhibition of the ATP-ubiquitin-proteasome pathway, inhibition of the signalization pathways involving protein kinase C

  20. Autómatas celulares alfa-beta

    OpenAIRE

    Benjamín Luna Benoso; Cornelio Yáñez Márquez

    2012-01-01

    Los autómatas celulares Alfa-Beta constituyen un puente conceptual entre dos áreas de investigación que han sido ajenas hasta el día de hoy: las memorias asociativas Alfa-Beta, por un lado, y los autómatas celulares, por el otro. Con los resultados de este artículo es posible aplicar las herramientas propias de las memorias asociativas Alfa-Beta en el ámbito de los autómatas celulares y, viceversa, se puede aplicar el bagaje teórico de los autómatas celulares en los algoritmos propios de las ...

  1. High energy beta rays and vectors of Bilharzia and Fasciola

    International Nuclear Information System (INIS)

    Preliminary investigations of the effects of high energy beta rays on Lymnea natalensis, the snail vector of Schistosoma haematobium have been conducted. Results show that in both stream and tap water, about 70% of the snails die when irradiated for up to 18 hours using a 15m Ci Sr-90 beta source. The rest of the snails die without further irradiation in 24 hours. It may then be possible to control the vectors of Bilharzia and Fasciola by using both the direct and indirect effects of high energy betas. (author)

  2. Substitutions over infinite alphabet generating (-\\beta)-integers

    CERN Document Server

    Dombek, Daniel

    2011-01-01

    This contribution is devoted to the study of positional numeration systems with negative base introduced by Ito and Sadahiro in 2009, called (-\\beta)-expansions. We give an admissibility criterion for more general case of (-\\beta)-expansions and discuss the properties of the set of (-\\beta)-integers. We give a description of distances within this set and show that this set can be coded by an infinite word over an infinite alphabet, which is a fixed point of a non-erasing non-trivial morphism.

  3. Refractory anaphylactoid shock potentiated by beta-blockers.

    Science.gov (United States)

    Javeed, N; Javeed, H; Javeed, S; Moussa, G; Wong, P; Rezai, F

    1996-12-01

    Allergic reactions, including anaphylactoid shock due to contrast material, are not uncommon. However, persistent anaphylactoid shock refractory to conventional therapy is rare. We present a case of refractory anaphylactoid shock during coronary angiography unresponsive to aggressive standard therapy in a patient on beta-blockers. Significant clinical improvement was noted upon administration of glucagon. Since beta-blockers are commonly used in patients with coronary artery disease, this potentially life-threatening complication has to be kept in mind with any procedure involving contrast media in patients on beta-blockers. Immediate access to glucagon by keeping it in the procedure room may be lifesaving in these situations. PMID:8958428

  4. Beta-delayed proton emission from $^{21}$Mg

    CERN Document Server

    Lund, M V; Briz, J A; Cederkäll, J; Fynbo, H O U; Jensen, J H; Jonson, B; Laursen, K L; Nilsson, T; Perea, A; Pesudo, V; Riisager, K; Tengblad, O

    2015-01-01

    Beta-delayed proton emission from $^{21}$Mg has been measured at ISOLDE, CERN, with a detection setup including particle identification capabilities. $\\beta$-delayed protons with center of mass energies between 0.39$\\,$MeV and 7.2$\\,$MeV were measured and used to determine the half life of $^{21}$Mg as $118.6\\pm 0.5\\,$ms. From a line shape fit of the $\\beta p$ branches we extract spectroscopic information about the resonances of $^{21}$Na. Finally an improved interpretation of the decay scheme in accordance with the results obtained in reaction studies is presented.

  5. Betas utilizadas por directivos y profesores europeos en 2009

    OpenAIRE

    Fernandez, Pablo; Bermejo, Vicente

    2009-01-01

    Este documento resume 1.466 respuestas a una encuesta por e-mail realizada a directivos de empresas y a profesores de finanzas europeos. 1.143 personas utilizan rentabilidad exigida y 824 utilizan betas para calcularlas. La mayoría (717) de estas 824 personas justifican las betas que utilizan con regresiones, webs, bases de datos, libros o artículos. Solamente 70 personas justifican las betas que utilizan empleando únicamente el sentido común. La proporción de directivos que utilizan rentabil...

  6. Is It Time to Beta Block the Septic Patient?

    Directory of Open Access Journals (Sweden)

    Philip Pemberton

    2015-01-01

    Full Text Available Beta blockers are some of the most studied drugs in the pharmacopoeia. They are already widely used in medicine for treating hypertension, chronic heart failure, tachyarrhythmias, and tremor. Whilst their use in the immediate perioperative patient has been questioned, the use of esmolol in the patients with established septic shock has been recently reported to have favourable outcomes. In this paper, we review the role of the adrenergic system in sepsis and the evidence for the use of beta stimulation and beta blockers from animal models to critically ill patients.

  7. Is It Time to Beta Block the Septic Patient?

    Science.gov (United States)

    Pemberton, Philip; Veenith, Tonny; Snelson, Catherine; Whitehouse, Tony

    2015-01-01

    Beta blockers are some of the most studied drugs in the pharmacopoeia. They are already widely used in medicine for treating hypertension, chronic heart failure, tachyarrhythmias, and tremor. Whilst their use in the immediate perioperative patient has been questioned, the use of esmolol in the patients with established septic shock has been recently reported to have favourable outcomes. In this paper, we review the role of the adrenergic system in sepsis and the evidence for the use of beta stimulation and beta blockers from animal models to critically ill patients. PMID:26557668

  8. Polymerization of beta-amino acids in aqueous solution

    Science.gov (United States)

    Liu, R.; Orgel, L. E.; Bada, J. L. (Principal Investigator)

    1998-01-01

    We have compared carbonyl diimidazole (CDI) and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDAC) as activating agents for the oligomerization of negatively-charged alpha- and beta-amino acids in homogeneous aqueous solution. alpha-Amino acids can be oligomerized efficiently using CDI, but not by EDAC. beta-Amino acids can be oligomerized efficiently using EDAC, but not by CDI. Aspartic acid, an alpha- and beta-dicarboxylic acid is oligomerized efficiently by both reagents. These results are explained in terms of the mechanisms of the reactions, and their relevance to prebiotic chemistry is discussed.

  9. Tracking debris disks within the Beta Pictoris Moving Group

    Science.gov (United States)

    Debes, J.

    2014-09-01

    Beta Pictoris represents a stunning example of a young planetary system with a debris disk, moving through local space with a host of other co-eval companion stars. These fellow travelers provide additional understanding for placing the Beta Pictoris disk into a proper context with regards to planet formation throughout the galaxy and our own Solar System. I will review the members of the Beta Pictoris moving group and catalog the latest results regarding the presence and understanding of debris disks around these other systems. Since these stars are close and very young, they represent an excellent opportunity for understanding the structure, composition, and grain properties of debris disks.

  10. Imaging the Beta-cell mass: why and how

    DEFF Research Database (Denmark)

    Saudek, Frantisek; Brogren, Carl-Henrik; Manohar, Srirang

    2008-01-01

    of the fate of beta-cells under disease and therapy conditions. This could pave the way for a new era of intervention by islet replacement and regeneration regimens. Monitoring the beta-cell mass requires a reliable method for noninvasive in vivo imaging. Such a method is not available at present due......-cells. This effect was demonstrated in many previous investigations, and has been further substantiated more recently. Thus, at present, IC2 seems to be the only useful marker for noninvasive functional imaging of native beta-cells. Experiments with a radioisotope-chelated IC2 structure on pancreas ex vivo showed...

  11. Mechanisms of pancreatic beta-cell growth and regeneration

    DEFF Research Database (Denmark)

    Nielsen, Jens Høiriis

    1989-01-01

    Information about the mechanism of beta-cell growth and regeneration may be obtained by studies of insulinoma cells. In the present study the growth and function of the rat insulinoma cell lines RINm5F and 5AH were evaluated by addition of serum, hormones, and growth factors. It was found...... of insulin mRNA content showed that the insulinoma cells only contained about 2% of that of normal rat beta-cells. These results are discussed in relation to the role of growth factors, oncogenes, and differentiation in the growth and regeneration of beta-cells....

  12. Scalar-mediated double beta decay and LHC

    CERN Document Server

    Gonzales, L; Hirsch, M; Kovalenko, S G

    2016-01-01

    The decay rate of neutrinoless double beta decay could be dominated by short-range diagrams involving heavy scalar particles ("topology-II" diagrams). Examples are diagrams with diquarks, leptoquarks or charged scalars. Here, we compare the discovery potential for lepton number violating signals at the LHC with constraints from dijet and leptoquark searches and the sensitivity of double beta decay experiments, using three example models. We note that already with 20/fb the LHC will test interesting parts of the parameter space of these models, not excluded by current limits on double beta decay.

  13. Astrocytic beta(2)-adrenergic receptors: from physiology to pathology.

    Science.gov (United States)

    Laureys, Guy; Clinckers, Ralph; Gerlo, Sarah; Spooren, Anneleen; Wilczak, Nadine; Kooijman, Ron; Smolders, Ilse; Michotte, Yvette; De Keyser, Jacques

    2010-07-01

    Evidence accumulates for a key role of the beta(2)-adrenergic receptors in the many homeostatic and neuroprotective functions of astrocytes, including glycogen metabolism, regulation of immune responses, release of neurotrophic factors, and the astrogliosis that occurs in response to neuronal injury. A dysregulation of the astrocytic beta(2)-adrenergic-pathway is suspected to contribute to the physiopathology of a number of prevalent and devastating neurological conditions such as multiple sclerosis, Alzheimer's disease, human immunodeficiency virus encephalitis, stroke and hepatic encephalopathy. In this review we focus on the physiological functions of astrocytic beta(2)-adrenergic receptors, and their possible impact in disease states. PMID:20138112

  14. Radioligands for imaging myocardial {alpha}- and &beta;-adrenoceptors

    Energy Technology Data Exchange (ETDEWEB)

    Riemann, B.; Schaefers, M.; Schober, O. [Dept. of Nuclear Medicine, Muenster Univ. (Germany); Law, M.P. [MRC Clinical Sciences Centre, Imperial Coll. School of Science, Technology and Medicine, Hammersmith Hospital, London (United Kingdom); Wichter, T. [Dept. of Cardiology and Angiology, Muenster Univ. (Germany)

    2003-02-01

    Alpha- and beta-adrenoceptors play an important role in the control of heart function. According to their molecular, biological, and pharmacological characteristics, they are subdivided into {alpha}{sub 1}-, {alpha}{sub 2}- and &beta;{sub 1}-, &beta;{sub 2}-, &beta;{sub 3}-, &beta;{sub 4}- adrenoceptors. In cardiac disease, there is often a selective downregulation of &beta;{sub 1}-adrenoceptors associated with a relative increase in &beta;{sub 2}- and {alpha}{sub 1}-adrenoceptors. Functional imaging techniques like single-photon emission tomography (SPECT) and positron emission tomography (PET) provide the unique capability for non-invasive assessment of cardiac adrenoceptors. Radioligands with high specific binding to cardiac {alpha}- and &beta;-adrenoceptors suitable for radiolabelling are required for clinical studies. The non-selective &beta;-adrenoceptor antagonist [{sup 11}C]CGP-12177 was used to quantify &beta;-adrenoceptor density using PET in patients with heart disease. New non-selective ligands (e. g. [{sup 11}C]CGP-12388, [{sup 18}F]CGP-12388, [{sup 11}C]carazolol and [{sup 18}F]fluorocarazolol) are currently evaluated; &beta;{sub 1}-selective radioligands (e. g. [{sup 11}C]CGP-26505, [{sup 11}C]bisoprolol, [{sup 11}C]HX-CH 44) and &beta;{sub 2}-selective radioligands (e. g. [{sup 11}C]formoterol, [{sup 11}C]ICI-118551) were assessed in animals. None of them turned out as suitable for cardiac PET. Potential radioligands for imaging cardiac {alpha}{sub 1}-adrenoceptors are based on prazosin. Whereas [{sup 11}C]prazosin shows low specific binding to myocardium, its derivative [{sup 11}C]GB67 looks more promising. The putative {alpha}{sub 2}-adrenoceptor radioligand [{sup 11}C]MK-912 shows high uptake in rodent myocardium but has not yet been evaluated in man. A number of radioligands were evaluated for assessing cardiac adrenoceptors using PET. New radioligands are needed to provide more insight into cardiac pathophysiology which may influence the

  15. Theory and calculation of finite beta drift wave turbulence

    International Nuclear Information System (INIS)

    Using numerical techniques, we calculate eigenmodes of the nonlinear universal mode with finite beta in order to determine the scaling of the saturation level of the instability with beta. We use two different renormalizations in the calculations and find that using the appropriate renormalization, we are able to recover Alcator density scaling, as originally found in analytic work by Molvig and Hirshman. We also find that the universal mode should be stable in ohmically heated tokamaks above a critical beta on the order of 0.02

  16. Instability of stock beta in Dhaka Stock Exchange, Bangladesh

    OpenAIRE

    Abu Taher Mollik; M. Khokan Bepari

    2010-01-01

    Purpose – The purpose of this paper is to examine the nature and extent of instability of capital asset pricing model (CAPM) beta in a small emerging capital market. Design/methodology/approach – Inter-period as well as intra beta instability are examined. Inter-period instability is examined by Mann-Whitney z-scores and Blume's regressions. Intra-period beta instability is examined using Bruesch-Pagan LM test and Chow break point test. Robustness tests are performed applying time-varying par...

  17. Determination BETA Dose In Ancient Pottery By Liquid Scintillation Counting

    International Nuclear Information System (INIS)

    This paper presents a method for measuring the gross alpha/beta radioactivity of ancient pottery by using the liquid scintillation analyzer, Tri - carb2770TR/SL in the alpha/beta discrimination counting mode. The beta radioactivity is converted to the annual dose, which can be applied in dating of pottery by thermoluminescence technique. In comparison with the radiocarbon techniques, the preliminary results have shown the liquid scintillation counting technique to be an efficient solution and may be effectively applied for ancient object dating in Vietnam. (author)

  18. High energy beta rays and vectors of Bilharzia and Fasciola

    Energy Technology Data Exchange (ETDEWEB)

    Fletcher, J.J.; Akpa, T.C.; Dim, L.A.; Ogunsusi, R.

    1988-01-01

    Preliminary investigations of the effects of high energy beta rays on Lymnea natalensis, the snail vector of Schistosoma haematobium have been conducted. Results show that in both stream and tap water, about 70% of the snails die when irradiated for up to 18 hours using a 15m Ci Sr-90 beta source. The rest of the snails die without further irradiation in 24 hours. It may then be possible to control the vectors of Bilharzia and Fasciola by using both the direct and indirect effects of high energy betas.

  19. Implementing GoF Design Patterns in BETA

    DEFF Research Database (Denmark)

    Agerbo, Ellen; Cornils, Aino

    1998-01-01

    In this paper it is investigated how well the Beta supports the Design Patterns presented in [GoF 95]. We go through the language constructs in Beta to show which prove especially useful when implementing these Design Patterns. It is a fact that several of the Design Patterns found in [GoF 95] can...... be implemented in a simpler and more straightforward way in Beta than in ordinary OO-languages. This leads us to consider whether it is true that the more advanced OO-language one uses, the more of these Design Patterns are included directly in the language constructs....

  20. Design of a superconducting low beta niobium resonator

    Indian Academy of Sciences (India)

    Prakash Potukuchi; Amit Roy

    2012-04-01

    The proposed high current injector for the superconducting Linac at the InterUniversity Accelerator Centre will have several accelerating structures, including a superconducting module which will contain low beta niobium resonators. A prototype resonator for the low beta module has been designed. The resonator has been carefully modelled to optimize the electromagnetic parameters. In order to validate them, a room-temperature copper model has been built and tested. In this paper we present details of the electromagnetic design of the low beta resonator, briefly discuss the mechanical and engineering design, and present results from the measurements on the room-temperature copper model.

  1. Beta-Cell Preservation…Is Weight Loss the Answer?

    OpenAIRE

    Mazza, Angela D.; Pratley, Richard E.; Smith, Steven R.

    2011-01-01

    Obesity is associated with an increased risk of type 2 diabetes (T2D). Pancreatic beta-cell failure is an early event in the development of glucose dysregulation and diabetes. Interventions to halt beta-cell failure in T2D include diet modification, exercise, and use of pharmacologic agents. There is evidence that abdominal obesity may contribute to diabetes through insulin resistance and beta-cell impairment. Pivotal long-term studies into the prevention of T2D have shown the importance of w...

  2. T violation in radiative $\\beta$ decay and electric dipole moments

    CERN Document Server

    Dekens, W G

    2015-01-01

    In radiative $\\beta$ decay, $T$ violation can be studied through a spin-independent $T$-odd correlation. We consider contributions to this correlation by beyond the standard model (BSM) sources of $T$-violation, arising above the electroweak scale. At the same time such sources, parametrized by dimension-6 operators, can induce electric dipole moments (EDMs). As a consequence, the manifestations of the $T$-odd BSM physics in radiative $\\beta$ decay and EDMs are not independent. Here we exploit this connection to show that current EDM bounds already strongly constrain the spin-independent $T$-odd correlation in radiative $\\beta$ decay.

  3. Three-dimensional drift chambers of the DCBA experiment for neutrinoless double beta decay search

    Energy Technology Data Exchange (ETDEWEB)

    Ishikawa, T., E-mail: ishikawat@hakone.phys.metro-u.ac.j [Tokyo Metropolitan University, Hachioji, Tokyo 192-0398 (Japan); Igarashi, H.; Sumiyoshi, T. [Tokyo Metropolitan University, Hachioji, Tokyo 192-0398 (Japan); Ishihara, N.; Iwai, G.; Iwase, H.; Kato, Y.; Kawai, M.; Kondou, Y.; Haruyama, T.; Inagaki, T.; Makida, Y.; Ohama, T.; Takahashi, K.; Yamada, Y. [High Energy Accel, Research Organization (KEK), Tsukuba, Ibaraki 305-0801 (Japan); Tashiro, E.; Ishizuka, T. [Shizuoka University, Naka, Hamamatsu, Shizuoka 432-8011 (Japan); Kitamura, S. [Nihon Institute of Medical Science, Iruma-gun, Saitama 350-0435 (Japan); Teramoto, Y. [Osaka City University, Sumiyoshi, Osaka 558-8585 (Japan); Nakano, I. [Okayama University, Okayama 700-8530 (Japan)

    2011-02-01

    The aim of the DCBA (Drift Chamber Beta-ray Analyzer) experiment is to search for neutrinoless double beta decay (0{nu}{beta}{beta}). The half-life of 0{nu}{beta}{beta} is expected to give us the information of Majorana nature and the absolute mass scale of neutrinos. A prototype test apparatus DCBA-T2 has the energy resolution of about 150 keV (FWHM) around 1 MeV. In order to check the detector performance, engineering runs detecting double beta decay of {sup 100}Mo started in May 2009 using natural Mo, which contains 9.6% of {sup 100}Mo. Ten candidates of the double beta decay ({beta}{beta}) have been detected so far. It has been found that the background events due to {sup 214}Bi decay are distinguishable from the double beta decays by detecting {alpha}-particles from {sup 214}Po.

  4. The shark bile salt 5 beta-scymnol abates acetaminophen toxicity, but not covalent binding.

    Science.gov (United States)

    Slitt, Angela Lucas; Naylor, Lee; Hoivik, J; Manautou, Jose E; Macrides, Theo; Cohen, Steven D

    2004-10-15

    Acetaminophen (APAP) toxicity involves both arylative and oxidative mechanisms. The shark bile salt, 5 beta-scymnol (5beta-S), has been demonstrated to act as an antioxidant and free radical scavenger in vitro. To determine if 5beta-S protects against either APAP-induced hepatic or renal toxicity, 3-4-month-old male Swiss Laca mice were given APAP (500 mg/kg), and 5beta-S (100 mg/kg) was given at 0 and 2 h after APAP. Plasma SDH at 12 h after APAP alone was 1630 U/l and BUN was 19 mg/dl versus 20 U/l and 10 mg/dl, respectively, in controls. Either simultaneous or 2 h delayed treatment with 5beta-S significantly decreased the APAP-induced SDH increase while only the simultaneous pretreatment prevented the BUN elevation. 5beta-S alone did not increase liver glutathione content. Western analysis of APAP covalent binding using anti-APAP antibodies indicated the 5beta-S did not alter protein arylation either qualitatively or quantitatively. These results suggest that 5beta-S treatment did not impair APAP activation and are consistent with 5beta-S protection that likely results from its antioxidant activity. PMID:15363587

  5. Conserved structure of amphibian T-cell antigen receptor beta chain.

    Science.gov (United States)

    Fellah, J S; Kerfourn, F; Guillet, F; Charlemagne, J

    1993-07-15

    All jawed vertebrates possess well-differentiated thymuses and elicit T-cell-like cell-mediated responses; however, no surface T-cell receptor (TCR) molecules or TCR genes have been identified in ectothermic vertebrate species. Here we describe cDNA clones from an amphibian species, Ambystoma mexicanum (the Mexican axolotl), that have sequences highly homologous to the avian and mammalian TCR beta chains. The cloned amphibian beta chain variable region (V beta) shares most of the structural characteristics with the more evolved vertebrate V beta and presents approximately 56% amino acid identities with the murine V beta 14 and human V beta 18 families. The two different cloned axolotl beta chain joining regions (J beta) were found to have conserved all the invariant mammalian J beta residues, and in addition, the presence of a conserved glycine at the V beta-J beta junction suggests the existence of diversity elements. The extracellular domains of the two axolotl beta chain constant region isotypes C beta 1 and C beta 2 show an impressively high degree of identity, thus suggesting that a very efficient mechanism of gene correction has been in operation to preserve this structure at least from the early tetrapod evolution. The transmembrane axolotl C beta domains have been less well conserved when compared to the mammalian C beta but they do maintain the lysine residue that is thought to be involved in the charged interaction between the TCR alpha beta heterodimer and the CD3 complex. PMID:8341702

  6. Neutrinoless double beta decay in Gerda

    Science.gov (United States)

    Grabmayr, Peter; Gerda Collaboration

    2015-10-01

    The Germanium Detector Array (Gerda) experiment searches for the neutrinoless double beta decay in 76Ge. This lepton number violating process is predicted by extensions of the standard model. Gerda follows a staged approach by increasing mass and lowering the background level from phase to phase. Gerda is setup at the Gran Sasso underground laboratory of INFN, Italy. An array of high-purity germanium detectors is lowered directly in liquid argon for shielding and cooling. Further background reduction is achieved by an instrumented water buffer. In Phase I an exposure of 21.6 kg yr was collected at a background level of 10-2 cts/(keV kg yr). The lower limit on the half-life of 76Ge > 2 . 1 .1025 yr (90% C.L.) has been published. Further analyses search for decay into excited states or the accompanied Majoron decay. Presently, Phase II is in preparation which intends to reach a background level of 10-3 cts/(keV kg yr) and to increase the exposure to 100 kg yr. About 20 kg of novel thick-window BEGe (Broad Energy Germanium) detectors will be added and the liquid argon will be instrumented. The status of Phase II preparation and results from the commissioning runs will be presented as well as some further results from Phase I.

  7. Beta and low energy photon response

    International Nuclear Information System (INIS)

    This study quantifies the observed dosimeter response for a variety of beta and photon energies. The reportable skin dose is also included in the discussion. Presently, the reportable skin dose is determined by adding the nonpenetrating and penetrating dose components together. The scheme presently used to estimate the nonpenetrating dose component for personnel at Hanford utilizes the difference in light outputs of a TLD-700 chip filtered only by the security credential (total of 88 mg/cm2) and a TLD-700 chip filtered by a 0.064 cm thick aluminum filter as well as the credential. The study indicates that a maximum chip response occurs in the range of photon energies between 30 keV and 40 keV and results in an overestimation of the calculated nonpenetrating dose by a factor of approximately 2. The reportable skin dose is overestimated by a factor of approximately 2.5 following adding the nonpenetrating and penetrating dose components. The effect of removing the security credential is slight and tends to increase the steepness of slope in the photon response curve

  8. Experimental study of high beta toroidal plasmas

    International Nuclear Information System (INIS)

    Experiments on the Wisconsin Levitated Toroidal Octupole have produced a wide range of stable high β plasmas with β significantly above single fluid MHD theory predictions. A stable β approx. 8% plasma, twice the fluid limit, is obtained with 5 rho/sub i/ approx. L/sub n/ and tau/sub β/ approx. = 6000 tau/sub Alfven/ = 600 μsec. The enhanced stability is explained with a kinetic treatment that includes the effect of finite ion gyroradius which couples the ballooning mode to an ion drift wave. In a more collisional, large gyroradius (2 rho/sub i/ approx. L/sub n/) regime, a stable β approx. 35% plasma is obtained with a decay time of 1000 Alfven times. Measurement of the equilibrium magnetic field in this regime indicates that the diamagnetic current density is five times smaller than predicted by ideal MHD, probably due to ion gyroviscosity. Particle transport is anomalous and ranges from agreement with the classical diffusion rate at the highest beta, lowest field plasma (B/sub P/ = 200 G), to thirteen times the classical rate in a β=11%, high field plasma (B/sub P/ = 860 G) where the level of enhancement increase with magnetic field. Fluctuations in density, electrostatic potential, and magnetic field have been studied in plasmas with β from 0.1% to 40%

  9. Beta-2-Microglobulin in Autism Spectrum Disorders

    Directory of Open Access Journals (Sweden)

    Paula Goines

    2007-01-01

    Full Text Available Autism spectrum disorders (ASD are heterogeneous neurodevelopmental diseases of unknown etiology. There are no biological markers for ASD and current diagnosis is based on behavioral criteria. Recent data has shown that MHC I, a compound involved in adaptive immune function, is also involved in neurodevelopment, synaptic plasticity and behavior. It has been suggested that altered MHC I expression could play a part in neurodevelopmental diseases like ASD. To address this possibility, we measured plasma levels of beta-2-microglobulin (β2m, a molecule that associates with MHC I and is indicative of MHC I expression, in 36 children with autism, 28 typically developing controls and subjects with developmental disabilities (n=16 but not autism. The age range of our study population was 17-120 months. We found no statistically significant differences in plasma ß 2m levels between groups. Therefore, plasma levels of ß2m measured in early childhood in autism may not reflect changes in MHC class I in autism.

  10. Homocystinuria due to cystathionine beta synthase deficiency

    Directory of Open Access Journals (Sweden)

    Rao T

    2008-01-01

    Full Text Available A two year-old male child presented with cutis marmorata congenita universalis, brittle hair, mild mental retardation, and finger spasms. Biochemical findings include increased levels of homocysteine in the blood-106.62 µmol/L (normal levels: 5.90-16µmol/L. Biochemical tests such as the silver nitroprusside and nitroprusside tests were positive suggesting homocystinuria. The patient was treated with oral pyridoxine therapy for three months. The child responded well to this therapy and the muscle spasms as well as skin manifestations such as cutis marmorata subsided. The treatment is being continued; the case is reported here because of its rarity. Homocysteinuria arising due to cystathionine beta-synthase (CBS deficiency is an autosomal recessive disorder of methionine metabolism that produces increased levels of urinary homocysteine and methionine It manifests itself in vascular, central nervous system, cutaneous, and connective tissue disturbances and phenotypically resembles Marfan′s syndrome. Skin manifestations include malar flush, thin hair, and cutis reticulata / marmorata.

  11. Annealing Would Improve beta" - Alumina Solid Electrolyte

    Science.gov (United States)

    Williams, Roger; Homer, Margie; Ryan, Margaret; Cortez, Roger; Shields, Virgil; Kisor, Adam

    2003-01-01

    A pre-operational annealing process is under investigation as a potential means of preventing a sudden reduction of ionic conductivity in a Beta"-alumina solid electrolyte (BASE) during use. On the basis of tests, the sudden reduction of ionic conductivity, followed by a slow recovery, has been found to occur during testing of the solid electrolyte and electrode components of an alkali metal thermal-to-electric converter (AMTEC) cell. At this time, high-temperature tests of limited duration have indicated the superiority of the treated BASE, but reproducible tests over thousands of hours are necessary to confirm that microcracking has been eliminated. The ionic conductivity of the treated BASE is also measured to be higher than untreated BASE at 1,073 K in low-pressure sodium vapor. Microcracking resulting in loss of conductivity was not observed with treated BASE in one high-temperature experiment, but this result must be duplicated over very long testing times to be sure of the effect. Shorter annealing times (10 to 20 hours) were found to result in significantly less loss of mass; it may be necessary for the packed powder mixture to evolve some Na2O before the Na2O can leave the ceramic.

  12. Neutron bound beta-decay: BOB

    International Nuclear Information System (INIS)

    An experiment to observe the bound beta-decay (BOB) of the free neutron into a hydrogen atom and an electron anti-neutrino is described. The hyperfine spin state population of the monoenergetic hydrogen atom yields the neutrino left-handedness or possible right-handed admixture as well as possible small scalar and tensor contributions to the weak force. The BOB H(2s) hyperfine states can be separated with a Lamb-Shift Spin Filter. These monoenergetic H(2s) atoms are ionised into H− by charge exchanging within an argon cell. These ions are then separated using an adaptation of a MAC-E Filter. A first experiment is proposed at the FRMII high thermal-neutron flux beam reactor SR6 through-going beam tube, where we will seek to observe this rare neutron decay-mode for the first time and determine the branching ratio. After successful completion, the hyperfine spin state population will be determined, possibly at the ILL high-flux beam reactor through-going beam tube H6–H7, where the thermal neutron flux is a factor of four larger.

  13. Spectrochemical investigation of neodymium fluorinated. beta. -diketonates

    Energy Technology Data Exchange (ETDEWEB)

    Khomenko, V.S.; Rasshinina, T.A.; Lozinskij, M.O.; Fialkov, Yu.A.

    1982-10-01

    A spectrochemical study is carried out on neodymium complexes with ..beta..-diketonates of the following contents: Nd(tdh)/sub 4/xHP, Nd(tdh)/sub 3/xbipy, Nd(tdh)/sub 3/xC/sub 10/D/sub 8/N/sub 2/, Nd(tdh)/sub 3/xphen, Nd(fod)/sub 4/xHP, Nd(fod)/sub 3/xbipy, Nd(fod)/sub 3/xphen, where tdh - 1, 1, 1,-trifluoro-5, 5 dimethylhexanedione-2, 4; fod - 1, 1, 1, 2, 2, 3, 3-heptafluoro-7, 7-dimethyloctanedione-4, 6; bipy - 2, 2'-dipyridyl- phen - 1, 10-phenanthroline; p - piperidine; C/sub 10/D/sub 8/N/sub 2/ - deuterated 2, 2'-dipyridyl. A change in the metal-ligand bond character was determined by means of the nepheloxetic effect (band shift in absorption spectra at the expense of an interelectron repulsion decrease in the 4f-electron shell due to its expansion during the formation of partially covalent metal-ligand bonds). Mutual ligand effect on the complex properties was also studied using the mass spectrometric method. It is established that an extra addition of a bisheterocycle to a triligand rare-earth complex makes an average bond in a complex more covalent.

  14. Beta decay of 187Re and cosmochronology

    Science.gov (United States)

    Ashktorab, K.; Jänecke, J. W.; Becchetti, F. D.

    1993-06-01

    Uncertainties which limit the use of the 187-187Os isobaric pair as a cosmochronometer for the age of the galaxy and the universe include those of the partial half-lives of the continuum and bound-state decays of 187Re. While the total half-life of the decay is well established, the partial half-life for the continuum decay is uncertain, and several previous measurements are not compatible with each other. A high-temperature quartz proportional counter has been used in this work to remeasure the continuum decay of 187Re by introducing a metallo-organic rhenium compound into the counting gas. The measured beta end-point energy for the continuum decay of neutral 187Re to singly ionized 187Os of 2.70+/-0.09 keV agrees with earlier results. However, the present half-life measurement of (45+/-3) Gyr agrees within the quoted uncertainties only with the earlier measurement of Payne [Ph.D. thesis, University of Glasgow, 1965 (unpublished)] and Drever (private communication). The new half-life for the continuum decay and the total half-life of (43.5+/-1.3) Gyr, as reported by Linder et al. [Nature (London) 320, 246 (1986)] yield a branching ratio for the bound-state decay into discrete atomic states of (3+/-6)%. This is in agreement with the most recent calculated theoretical branching ratio of approximately 1%.

  15. New particle searches by double beta decay

    International Nuclear Information System (INIS)

    So far, neutrinoless double beta decay has not been observed, but the lifetime limit (3-10/sup 23/ years) is such a stringent one that its non-observation can set the best upper limit for the mass of the electron neutrino (if it is a Majorana particle) and the best lower limit on the mass of a heavy Majorana neutrino for a given coupling to the electron neutrino, ν/sub e/. In addition it provides the best limit on the coupling of light bosons, such as Majorons, to ν/sub e/, and also the best limit on the existence of right-handed currents in the case in which all right-handed Majorana neutrinos are heavier than all left-handed leptons. The apparatus has to have such low backgrounds even in the keV energy region that it also can be used to set the best terrestrial limits on the mass of solar axions and of other dark matter candidates

  16. Evolution of T cell receptor genes. Extensive diversity of V beta families in the Mexican axolotl.

    Science.gov (United States)

    Fellah, J S; Kerfourn, F; Charlemagne, J

    1994-11-15

    We have cloned 36 different rearranged variable regions (V beta) genes encoding the beta-chain of the T cell receptor in an amphibian species, Ambystoma mexicanum (the Mexican axolotl). Eleven different V beta segments were identified, which can be classified into 9 families on the basis of a minimum of 75% nucleotide identity. All the cloned V beta segments have the canonical features of known mammalian and avian V beta, including conserved residues Cys23, Trp34, Arg69, Tyr90, and Cys92. There seems to be a greater genetic distance between the axolotl V beta families than between the different V beta families of any mammalian species examined to date: most of the axolotl V beta s have fewer than 35% identical nucleotides and the less related families (V beta 4 and V beta 8) have no more than 23.2% identity (13.5% at the amino acid level). Despite their great mutual divergence, several axolotl V beta are sequence-related to some mammalian V beta genes, like the human V beta 13 and V beta 20 segments and their murine V beta 8 and V beta 14 homologues. However, the axolotl V beta 8 and V beta 9 families are not significantly related to any other V beta sequence at the nucleotide level and show limited amino acid similarity to mammalian V alpha, V kappa III, or VH sequences. The detection of nine V beta families among 35 randomly cloned V beta segments suggests that the V beta gene repertoire in the axolotl is probably larger than presently estimated. PMID:7963525

  17. Activity of beta-lactam beta-lactamase inhibitor combinations against extended spectrum beta-lactamase producing enterobacteriaceae in urinary isolates

    International Nuclear Information System (INIS)

    Objective: To determine the susceptibility pattern of beta-lactam beta-lactamase inhibitor combinations against extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae in urinary isolates. Study Design: Observational study. Place and Duration of Study: Ziauddin University Hospital, Karachi, from February to October 2008. Methodology: A total of 190 consecutive non-duplicate isolates of ESBL producing Enterobacteriaceae from urine samples of in-patients were included in the study. Urinary samples from out-patients, repeat samples and non-ESBL producing isolates were excluded. Detection of ESBL was carried out by double disk diffusion technique. Antimicrobial susceptibility testing was performed using modified Kirby Bauer's disk diffusion method according to CLSI guidelines. Statistical analysis was performed by SPSS version 10. Results: Of the 190 ESBL isolates tested, 88 cases (46.31%) were sensitive and 6 cases (3.15%) were resistant to all three combinations, the rest 96 cases (50.52%) were resistant to at least one of the combinations. Susceptibility pattern of cefoperazone/sulbactam, piperacillin/tazobactam, and amoxicillin/clavulanic acid was 95.26, 92.10, and 44.31 percent respectively. Conclusion: Cefoperazone/sulbactam exhibited the best activity against ESBL producing Enterobacteriaceae followed by piperacillin/tazobactam. Hospital antibiotic policies should be reviewed periodically to reduce the usage of extended spectrum cephalosporins and replace them with beta-lactam beta-lactamase inhibitor combinations agent for treating urinary tract infections. (author)

  18. [Compensatory changes in beta 2-microglobulin handling in the remnant tubules after contralateral nephrectomy. Observations of beta 2-microglobulin excretion into the urine].

    Science.gov (United States)

    Higashi, Y; Kawamura, J; Yoshida, O

    1985-11-01

    Serum and urinary beta 2-microglobulin (S-, U-beta 2MG), and creatinine clearance (C-cr) were examined in 41 nephrectomy cases, and changes in glomerular and tubular handling of beta 2MG such as filtered beta 2MG (Fil-beta 2MG), reabsorption of beta 2MG (Reab-beta 2MG) and fractional excretion of beta 2MG (FE-beta 2MG) were studied. Serum creatinine (S-cr) and S-beta 2MG increased significantly after nephrectomy. C-cr decreased immediately after nephrectomy (80%), but recovered up to 87% in 2 to 4 days postoperatively. Fil-beta 2MG decreased immediately after nephrectomy, but increased up to more than the preoperative level in 2 to 4 days postoperatively. On the other hand, Reab-beta 2MG decreased significantly immediately after nephrectomy, and it took 5 to 8 days until recovery. Consequently, urinary excretion of beta 2MG (Ex-beta 2MG) and FE-beta 2MG increased significantly 0 to 4 days postoperatively. These increases in Ex-beta 2MG and FE-beta 2MG were much higher than those seen in diabetic nephropathy, cadmium nephropathy and Cis-diamminedichloroplatinum (II) (CDDP) intoxication, and were not due to drug intoxication such as general anesthesia or antibiotics, but due to glomerulo-tubular unbalance. Clinical data of renal tubular handling of beta 2-microglobulin in cases of interferon therapy or unilateral nephrectomy revealed many interesting aspects of glomerulo-tubular adaptations, and micropuncture study or isolated tubule perfusion study are awaited. PMID:3911767

  19. Evaluation of in vivo partial beta 1/beta 2-agonist activity: a dose-ranging study with carteolol.

    OpenAIRE

    Wheeldon, N M; McDevitt, D G; Lipworth, B J

    1992-01-01

    1. The aims of this study were to investigate the partial agonist profile of carteolol and evaluate methodology for differentiating relative beta 1 and beta 2 partial agonist activity (PAA) in vivo. 2. Eight normal subjects received single oral doses of carteolol 10 mg, 30 mg and 60 mg; nadolol 40 mg; pindolol 30 mg and placebo, given in a single-blind, randomised crossover design. 3. beta 1-PAA was demonstrated with carteolol by dose-related increases in resting heart rate and systolic blood...

  20. Biodegradable films containing {alpha}-tocopherol/{beta}-cyclodextrin complex; Filmes biodegradaveis contendo {alpha}-tocoferol complexado em {beta}-ciclodextrina

    Energy Technology Data Exchange (ETDEWEB)

    Motta, Caroline; Martelli, Silvia M.; Soldi, Valdir, E-mail: vsoldi@qmc.ufsc.br [Lab. de Materiais Polimericos (POLIMAT), Dept. de Quimica, Universidade Federal de Santa Catarina, Florianopolis, SC (Brazil); Barreto, Pedro L.M. [Lab. de Reologia (REOLAB), Dept. de Ciencia e Tecnologia de Alimentos, Universidade Federal de Santa Catarina, Florianopolis, SC (Brazil)

    2011-07-01

    The growing environmental concern about pollution and the need to reduce dependence of plastic industry in relation to non-renewable resources has increased the interest of both researchers and industry in the use of biopolymers. In this work {beta}-cyclodextrin/{alpha}-tocopherol complexes were prepared and characterized. In order to obtain polymeric active biofilms, the {beta}-cyclodextrin/{alpha}-tocopherol complex was incorporated into a polymeric matrix of carboxymethylcellulose. The {beta}-cyclodextrin/{alpha}-tocopherol complex was characterized through of X-ray diffraction and thermogravimetric analysis. The physicochemical properties of the films incorporated with the complex were evaluated through mechanical and colorimetric analysis and moisture sorption isotherm. (author)