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Sample records for betatron phase advance

  1. Betatron phase advance measurement at SPEAR

    International Nuclear Information System (INIS)

    Morton, P.L.; Pellegrin, J.L.; Raubenheimer, T.; Ross, M.

    1987-02-01

    There are many reasons to determine the betatron phase advance between two azimuthal positions in a circular accelerator or storage ring. We have measured the betatron phase advance between various pairs of azimuthal points in the SPEAR Storage Ring by two different methods. The first method is to excite a steady state coherent betatron oscillation with a network analyzer. The second method is to excite a free coherent betatron oscillation with an impulse kick, and to digitally sample the transverse position of the beam at the pickup stations. The results of these digital samples are Fourier analyzed with a computer to obtain the phase advance. The second method is discussed, and the experimental results compared to theory

  2. Betatron phase advance measurement at SPEAR

    International Nuclear Information System (INIS)

    Morton, P.L.; Pellegrin, J.L.; Raubenheimer, T.; Ross, M.

    1987-01-01

    There are many reasons to determine the betatron phase advance between two azimuthal positions in a circular accelerator or storage ring. The authors measured the betatron phase advance between various pairs of azimuthal points in the SPEAR Storage Ring by two different methods. The first method is to excite a steady state coherent betatron oscillation with a network analyzer. The second method is to excite a free coherent betatron oscillation with an impulse kick, and to digitally sample the transverse position of the beam at the pickup stations. The results of these digital samples are Fourier analyzed with a computer to obtain the phase advance. The second method is discussed, and the experimental results compared to theory

  3. The effects of betatron phase advances on beam-beam and its compensation in RHIC

    Energy Technology Data Exchange (ETDEWEB)

    Luo, Y.; Fischer, W.; Gu, X.; Tepikian, S.; Trbojevic, D.

    2011-03-28

    In this article we perform simulation studies to investigate the effects of betatron phase advances between the beam-beam interaction points on half-integer resonance driving term, second order chromaticty and dynamic aperture in RHIC. The betatron phase advances are adjusted with artificial matrices inserted in the middle of arcs. The lattices for the 2011 RHIC polarized proton (p-p) run and 2010 RHIC Au-Au runs are used in this study. We also scan the betatron phase advances between IP8 and the electron lens for the proposed Blue ring lattice with head-on beam-beam compensation.

  4. Synchronisation of the LHC Betatron Coupling and Phase Advance Measurement System

    CERN Document Server

    Gasior, M

    2014-01-01

    The new LHC Diode ORbit and OScillation (DOROS) system will provide beam position readings with submicrometre resolution and at the same time will be able to perform measurements of local betatron coupling and beam phase advance with micrometre beam excitation. The oscillation sub-system employs gain-controlled RF amplifiers, shared with the orbit system, and followed by dedicated diode detectors to demodulate the beam oscillation signals into the kHz frequency range, subsequently digitized by multi-channel 24-bit ADCs. The digital signals are processed in each front-end with an FPGA and the results of reduced throughput are sent using an Ethernet protocol to a common concentrator, together with the orbit data. The phase advance calculation between multiple Beam Position Monitors (BPMs) requires that all DOROS front-ends have a common phase reference. This paper presents methods used to generate such a reference and to maintain a stable synchronous sampling on all system front-ends. The performance of the DOR...

  5. Measurement of the betatron phase advance and betatron amplitude ratio at the SPP-barS collider

    International Nuclear Information System (INIS)

    Bossart, R.; Scandale, W.

    1987-01-01

    A technique for the precise measurement of lattice functions in a hadron collider has been developed. The betatron functions on either side of the two low beta insertions of the SPS collider have been determined from the measured amplitude and phase of horizontal beam oscillations with a peak amplitude of 40 μm. Four directional couplers and four synchronous receivers working at 200 MHz monitor the betatron oscillations of the beam excited by the fast deflectors of the damper. A fast Fourier transform of the signals provides the phase and amplitude ratio of the beam oscillations between any pair of monitors. The relative amplitude and phase of the beam oscillations can be measured with an accuracy of 0 in phase. For achieving such an accuracy a special calibration method has been implemented to determine the propagation times and amplification factors of the measuring equipment, using the intensity signals of the beam itself. The same equipment can be used also for measuring the beam transfer function by injecting white noise into the beam deflectors

  6. Transverse betatron tune measurements

    International Nuclear Information System (INIS)

    Serio, M.

    1989-01-01

    In this paper the concept of the betatron tune and the techniques to measure it are discussed. The smooth approximation is introduced along with the terminology of betatron oscillations, phase advance and tune. Single particle and beam spectra in the presence of synchro-betatron oscillations are treated with emphasis on the consequences of sampling the beam position. After a general presentation of various kinds of beam position monitors and transverse kickers, the time domain and frequency domain analysis of the beam response to a transverse excitation are discussed and several methods and applications of the tune measurements are listed

  7. Energy measurements from betatron oscillations

    International Nuclear Information System (INIS)

    Himel, T.; Thompson, K.

    1989-03-01

    In the Stanford Linear Collider the electron beam is accelerated from 1--50 GeV in a distance of 3 km. The energy is measured and corrected at the end with an energy feedback loop. There are no bends within the linear accelerator itself, so no intermediate energy measurements are made. Errors in the energy profile due to mis-phasing of the rf, or due to calibration errors in the klystrons' rf outputs are difficult to detect. As the total betatron phase advance down the accelerator is about 30 /times/ 2π, an energy error of a few percent can cause a large error in the total phase advance. This in turn degrades the performance of auto-steering programs. We have developed a diagnostic program which generates and measures several betatron oscillations in the accelerator. It then analyzes this oscillation, looking for frequency changes which indicate energy errors. One can then compensate for or correct these energy errors. 6 refs., 1 fig

  8. The tandem betatron accelerator

    International Nuclear Information System (INIS)

    Keinigs, R.

    1991-01-01

    This paper reports that the tandem betatron is a compact, high-current induction accelerator that has the capability to accelerate electrons to an energy of order one gigavolt. Based upon the operating principle of a conventional betatron, the tandem betatron employs two synchronized induction cores operating 180 degrees out of phase. Embedded within the cores are the vacuum chambers, and these are connected by linear transport sections to allow for moving the beam back and forth between the two betatrons. The 180 degree phase shift between the core fluxes permits the circumvention of the flux swing constraint that limits the maximum energy gain of a conventional betatron. By transporting the beam between the synchronized cores, an electron can access more than one acceleration cycle, and thereby continue to gain energy. This added degree of freedom also permits a significant decrease in the size of the magnet system. Biasing coils provide independent control of the confining magnetic field. Provided that efficient beam switching can be performed, it appears feasible that a one gigavolt electron beam can be generated and confined. At this energy, a high current electron beam circulating in a one meter radius orbit could provide a very intense source of short wavelength (λ < 10 nm) synchrotron radiation. This has direct application to the emerging field of x-ray lithography. At more modest energies (10 MeV-30 MEV) a compact tandem betatron could be employed in the fields of medical radiation therapy, industrial radiography, and materials processing

  9. Experimental results of the betatron sum resonance

    International Nuclear Information System (INIS)

    Wang, Y.; Ball, M.; Brabson, B.

    1993-06-01

    The experimental observations of motion near the betatron sum resonance, ν x + 2ν z = 13, are presented. A fast quadrupole (Panofsky-style ferrite picture-frame magnet with a pulsed power supplier) producing a betatron tune shift of the order of 0.03 at rise time of 1 μs was used. This quadrupole was used to produce betatron tunes which jumped past and then crossed back through a betatron sum resonance line. The beam response as function of initial betatron amplitudes were recorded turn by turn. The correlated growth of the action variables, J x and J z , was observed. The phase space plots in the resonance frame reveal the features of particle motion near the nonlinear sum resonance region

  10. Phase advance and β function measurements using model-independent analysis

    OpenAIRE

    Chun-xi Wang; Vadim Sajaev; Chih-Yuan Yao

    2003-01-01

    Phase advance and β function are basic lattice functions characterizing the linear properties of an accelerator lattice. Accurate and efficient measurements of these quantities are important for commissioning and operating a machine. For rings with little coupling, we report a new method to measure these lattice functions based on the model-independent analysis technique, which uses beam histories of excited betatron oscillations measured simultaneously at a large number of beam position moni...

  11. Synchro-betatron resonances driven by the beam-beam interaction

    International Nuclear Information System (INIS)

    Furman, M.A.

    1994-01-01

    We present a selective summary of the discussions on beam-beam-driven synchrobetatron resonances at the 6th Advanced ICFA Beam Dynamics Workshop on the subject ''Synchro-Betatron Resonances,'' held in Funchal (Madeira, Portugal), October 24--30, 1993

  12. High current betatron research at the University of New Mexico

    International Nuclear Information System (INIS)

    Humphries, S. Jr.; Len, L.K.

    1987-01-01

    Betatrons are among the simplest of high energy accelerators. Their circuit is equivalent to a step-up transformer; the electron beam forms a multi-turn secondary winding. Circulation of the beam around the flux core allows generation of high energy electrons with relatively small core mass. As with any transformer, a betatron is energy inefficient at low beam current; the energy balance is dominated by core losses. This fact has prompted a continuing investigation of high current betatrons as efficient, compact sources of beta and gamma radiation. A program has been supported at the University of New Mexico by the Office of Naval Research to study the physics of high current electron beams in circular accelerators and to develop practical technology for high power betatrons. Fabrication and assembly of the main ring was completed in January of this year. In contrast to other recent high current betatron experiments the UNM device utilizes a periodic focusing system to contain high current beams during the low energy phase of the acceleration cycle. The reversing cusp fields generated by alternating polarity solenoidal lenses cancel beam drift motions induced by machine errors. In consequence, they have found that the cusp geometry has had significantly better stability properties than a monodirectional toroidal field. In comparison to other minimum-Β geometries such as the Stelllatron cusps have open field lines which facilitate beam injection and neutralization

  13. Betatrons with kiloampere beams

    International Nuclear Information System (INIS)

    Peterson, J.M.

    1982-11-01

    Although the magnetic-induction method of acceleration used in the betatron is inherently capable of accelerating intense particle beams to high energy, many beam-instability questions arise when beams in the kilo-ampere range are considered. The intense electromagnetic fields produced by the beam, and by the image currents and charges induced in the surrounding walls, can produce very disruptive effects. Several unstable modes of collective oscillation are possible; the suppression of any one of them usually involves energy spread for Landau damping and careful design of the electrical character of the vacuum chamber. The various design criteria are often mutually incompatible. Space-charge detuning can be severe unless large beam apertures and high-energy injection are used. In order to have an acceptably low degree of space-charge detuning in the acceleration of a 10-kilo-ampere electron beam, for example, an injection energy on the order of 50 MeV seems necessary, in which case the forces due to nearby wall images can have a larger effect than the internal forces of the beam. A method of image compensation was invented for reducing the net image forces; it serves also to decrease the longitudinal beam impedance and thus helps alleviate the longitudinal instability as well. In order to avoid the ion-electron collective instability a vacuum in the range of 10 - 8 torr is required for an acceleration time of 1 millisecond. A multi-ring betatron system using the 50-MeV Advanced Test Accelerator at LLNL as an injector was conceptually designed

  14. Modified betatron for ion beam fusion

    International Nuclear Information System (INIS)

    Rostoker, N.; Fisher, A.

    1986-01-01

    An intense neutralized ion beam can be injected and trapped in magnetic mirror or tokamak geometry. The details of the process involve beam polarization so that the beam crosses the fringing fields without deflection and draining the polarization when the beam reaches the plasma. Equilibrium requires that a large betatron field be added in tokamak geometry. In mirror geometry a toroidal field must be added by means of a current along the mirror axis. In either case, the geometry becomes that of the modified betatron which has been studied experimentally and theoretically in recent years. We consider beams of d and t ions with a mean energy of 500 kev and a temperature of about 50 kev. The plasma may be a proton plasma with cold ions. It is only necessary for beam trapping or to carry currents. The ion energy for slowing down is initially 500 kev and thermonuclear reactions depend only on the beam temperature of 50 kev which changes very slowly. This new configuration for magnetic confinement fusion leads to an energy gain of 10--20 for d-t reactions whereas previous studies of beam target interaction predicted a maximum energy gain of 3--4. The high beam energy available with pulsed ion diode technology is also essential for advanced fuels. 16 refs., 3 figs

  15. Improved control of the betatron coupling in the Large Hadron Collider

    Science.gov (United States)

    Persson, T.; Tomás, R.

    2014-05-01

    The control of the betatron coupling is of importance for safe beam operation in the LHC. In this article we show recent advancements in methods and algorithms to measure and correct coupling. The benefit of using a more precise formula relating the resonance driving term f1001 to the ΔQmin is presented. The quality of the coupling measurements is increased, with about a factor 3, by selecting beam position monitor (BPM) pairs with phase advances close to π/2 and through data cleaning using singular value decomposition with an optimal number of singular values. These improvements are beneficial for the implemented automatic coupling correction, which is based on injection oscillations, presented in the article. Furthermore, a proposed coupling feedback for the LHC is presented. The system will rely on the measurements from BPMs equipped with a new type of high resolution electronics, diode orbit and oscillation, which will be operational when the LHC restarts in 2015. The feedback will combine the coupling measurements from the available BPMs in order to calculate the best correction.

  16. Improved control of the betatron coupling in the Large Hadron Collider

    Directory of Open Access Journals (Sweden)

    T. Persson

    2014-05-01

    Full Text Available The control of the betatron coupling is of importance for safe beam operation in the LHC. In this article we show recent advancements in methods and algorithms to measure and correct coupling. The benefit of using a more precise formula relating the resonance driving term f_{1001} to the ΔQ_{min} is presented. The quality of the coupling measurements is increased, with about a factor 3, by selecting beam position monitor (BPM pairs with phase advances close to π/2 and through data cleaning using singular value decomposition with an optimal number of singular values. These improvements are beneficial for the implemented automatic coupling correction, which is based on injection oscillations, presented in the article. Furthermore, a proposed coupling feedback for the LHC is presented. The system will rely on the measurements from BPMs equipped with a new type of high resolution electronics, diode orbit and oscillation, which will be operational when the LHC restarts in 2015. The feedback will combine the coupling measurements from the available BPMs in order to calculate the best correction.

  17. Algorithms for a Precise Determination of the Betatron Tune

    CERN Document Server

    Bartolini, R; Giovannozzi, Massimo; Todesco, Ezio; Scandale, Walter

    1996-01-01

    In circular accelerators the precise knowledge of the betatron tune is of paramount importance both for routine operation and for theoretical investigations. The tune is measured by sampling the transverse position of the beam for N turns and by performing the FFT of the stored data. One can also evaluate it by computing the Average Phase Advance (APA) over N turns. These approaches have an intrinsic error proportional to 1/N. However, there are special cases where either a better precision or a faster measurement is desired. More efficient algorithms can be used, as those suggested by E.Asseo [1] and recently by J. Laskar [2]. They provide tune estimates by far more precise than those of a plain FFT, as discussed in Ref. [3]. Another important isssue is the effect of the finite resolution of the instrumentation used to measure the beam position. This introduces a noise and the frequency response of the beam is modified [4,5} thus reducing the precision by which the tune is determined. In Section 2 we recall ...

  18. Application of betatrons to quality control of structures

    International Nuclear Information System (INIS)

    Klevtsov, V.A.; Matveev, Yu.K.; Trefilov, V.V.

    1986-01-01

    The results of laboratory investigations on the applicability of modificated PMB-6 betatron to quality control of reinforced concrete structures are presented. The investigations have been performed for the purposes of refinement of the technique for detecting voids and establishing real reinforcement. On the basis of experimental investigations the technique and schemes of structure translucence have been developed. Examples of using betatrons for flaw detection of reinforred concrete structures are given

  19. Betatron radiation from a laser-plasma accelerator

    International Nuclear Information System (INIS)

    Schnell, Michael

    2014-01-01

    The presented thesis investigates the processes which lead to the generation of highenergetic X-ray radiation, also known as ''betatron radiation'', by means of a relativistic laser-plasma interaction. The generated betatron radiation has been extensively characterized by measuring its radiated intensity, energy distribution, far-field beam profile, and source size. It was shown for the first time that betatron radiation can be used as a non-invasive diagnostic tool to retrieve very subtle information on the electron acceleration dynamics within the plasma wave. Furthermore, a compact polarimeter setup has been developed in a unique experiment in which the polarization state of the laser-plasma generated betatron radiation was measured in single-shot mode. This lead to a detailed study of the orientation of the electron trajectory within the plasma interaction. By controlling the injection of the electrons into the plasma wave it was demonstrated that one can tune the polarization state of the emitted X-rays. This result is very promising for further applications, particularly for feeding the electrons into an additional conventional accelerator or a permanent magnet based undulator for the production of intense X-ray beams. During this work, the experimental setup for accelerating electrons and generating high-energy X-ray beams was consistently improved: to enhance both its reliability and stability. Subsequently, the betatron radiation was used as a reliable diagnostic tool of the electron dynamics within the plasma. Parallel to the experimental work, 3-Dimensional Particle-In-Cell (3D-PlC) simulations were performed together with colleagues from the University of Duesseldorf. The simulations included the electron acceleration and the X-ray generation processes together with the recoil force acting on an accelerating electron caused by the emitted radiation during which one can also ascertain its polarization state. The simulations proved to be in good agreement

  20. Synchro-betatron resonance excitation in LEP

    International Nuclear Information System (INIS)

    Myers, S.

    1987-01-01

    The excitation of synchrotro-betatron resonances due to spurious dispersion and induced transverse deflecting fields at the RF cavities has been simulated for the LEP storage ring. These simulations have been performed for various possible modes of operation. In particular, a scenario has been studied in which LEP is operated at the maximum possible value of the synchrotron tune throughout the acceleration cycle, in an attempt to maximise the threshold intensity at which the Transverse Mode Coupling Instability (TMCI) occurs. This mode of operation necessitates the crossing of synchro-betatron resonances at some points in the acceleration cycle if low order non-linear machine resonances are to be avoided. Simulations have been performed in which the machine tune is swept across these synchro-betratron resonances at a rate given by the bandwidth of the magnet plus power supply circuits of the main quadrupole chain. The effect of longitudinal and transverse wake-fields on the excitation of these resonances has been investigated. These studies indicate that the distortion of the RF potential well caused by the longitudinal wake fields increases the non-linear content of the synchrotron motion and consequently increases significantly the excitation of the higher order synchro-betatron resonances

  1. Application of a Betatron in Photonuclear Activation Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Brune, D [AB Atomenergi, Nykoeping (Sweden); Mattsson, K; Liden, K [Dept . of Radiation Physics, Univ. of Lund (Sweden)

    1968-08-15

    The present study concerns the determination of fluorine, iodine, lead and mercury by means of photonuclear activation technique using a betatron. The detection limit obtained for the elements in the above given sequence amounted to 3, 50, 400 and 15 {mu}g respectively. The technique has been applied in the determination of iodine in pharmaceuticals. A rotating sample holder device was inserted in the Bremsstrahlung beam of the betatron in order to ensure uniform irradiation of the samples.

  2. Measurement of betatron-tune in the KEK 12 GeV-PS/J-PARC

    International Nuclear Information System (INIS)

    Miura, Takako; Toyama, Takeshi; Igarashi, Susumu; Hayashi, Naoki

    2004-01-01

    Measurement of betatron-tune in the KEK 12 GeV-PS is performed by using band limited white noise which excites coherent betatron oscillations via stripline unit. We compared the results of the measurement for betatron oscillation amplitude with the result of calculation, and confirmed the consistency. The design of the tune-monitor in J-PARC was also discussed applying this result. (author)

  3. Betatron tune measurement

    International Nuclear Information System (INIS)

    Dinev, D.

    2001-01-01

    On the basis of the comparative review of the methods for the betatron tune measurement in cyclic accelerators of synchrotrons type, the research of these methods is carried out from the point of view of their applicability to Nuclotron. Both methods using measurement of the statistical fluctuations of the beam current (Schottky noise) and methods using coherent beam excitation have been discussed. The emphasis is on the final results of importance for the tune measurement practice. Signal processing is briefly discussed too

  4. Investigation of betatron instability in a wiggler pumped ion-channel free electron laser

    Energy Technology Data Exchange (ETDEWEB)

    Raghavi, A [Physics Department, Payame Noor University, 19395-4697 (Iran, Islamic Republic of); Mehdian, H, E-mail: Raghavi@tmu.ac.ir, E-mail: Mehdian@tmu.ac.ir [Department of Physics, Teacher Training University, Tehran (Iran, Islamic Republic of)

    2011-10-15

    Betatron emission from an ion-channel free electron laser in the presence of a helical wiggler pump and in the high gain regime is studied. The dispersion relation and the frequency of betatron emission are derived. Growth rate is illustrated and maximum growth rate as a function of ion-channel density is considered. Finally, the relation between beam energy, the density of ion channel and the region of betatron emission is discussed.

  5. Betatron tune correction schemes in nuclotron

    International Nuclear Information System (INIS)

    Shchepunov, V.A.

    1992-01-01

    Algorithms of the betatron tune corrections in Nuclotron with sextupolar and octupolar magnets are considered. Second order effects caused by chromaticity correctors are taken into account and sextupolar compensation schemes are proposed to suppress them. 6 refs.; 1 tab

  6. Betatron radiation based diagnostics for plasma wakefield accelerated electron beams at the SPARC-LAB test facility

    Energy Technology Data Exchange (ETDEWEB)

    Shpakov, V.; Anania, M.P.; Biagioni, A.; Chiadroni, E. [INFN - LNF, via Enrico Fermi 40, 00044 Frascati (Italy); Cianchi, A. [INFN - LNF, via Enrico Fermi 40, 00044 Frascati (Italy); “Tor Vergata” University, via della Ricerca Scientifica 1, 00133 Rome (Italy); Curcio, A. [INFN - LNF, via Enrico Fermi 40, 00044 Frascati (Italy); Dabagov, S. [INFN - LNF, via Enrico Fermi 40, 00044 Frascati (Italy); P.N. Lebedev Physical Institute RAS, Leninskiy Prospekt 53, 119991 Moscow (Russian Federation); NRNU “MEPhI”, Kashirskoe highway 31, 115409 Moscow (Russian Federation); Ferrario, M.; Filippi, F. [INFN - LNF, via Enrico Fermi 40, 00044 Frascati (Italy); Marocchino, A. [Dipartimento SBAI Universitá di Roma ‘La Sapienza’, via Antonio Scarpa 14/16, 00161 Rome (Italy); Paroli, B. [INFN - MI, via Celoria 16, 20133 Milan (Italy); Pompili, R. [INFN - LNF, via Enrico Fermi 40, 00044 Frascati (Italy); Rossi, A.R. [INFN - MI, via Celoria 16, 20133 Milan (Italy); Zigler, A. [Racah Institute of Physics Hebrew University of Jerusalem (Israel)

    2016-09-01

    Recent progress with wake-field acceleration has shown a great potential in providing high gradient acceleration fields, while the quality of the beams remains relatively poor. Precise knowledge of the beam size at the exit from the plasma and matching conditions for the externally injected beams are the key for improvement of beam quality. Betatron radiation emitted by the beam during acceleration in the plasma is a powerful tool for the transverse beam size measurement, being also non-intercepting. In this work we report on the technical solutions chosen at SPARC-LAB for such diagnostics tool, along with expected parameters of betatron radiation. - Highlights: • The betatron radiation parameters in SPARC-LAB wakefiled experiments were studied. • The differences with betatron radiation in other wake-field experiments were highlighted. • The solution for betatron radiation detection was investigated.

  7. Betatron radiation based diagnostics for plasma wakefield accelerated electron beams at the SPARC-LAB test facility

    International Nuclear Information System (INIS)

    Shpakov, V.; Anania, M.P.; Biagioni, A.; Chiadroni, E.; Cianchi, A.; Curcio, A.; Dabagov, S.; Ferrario, M.; Filippi, F.; Marocchino, A.; Paroli, B.; Pompili, R.; Rossi, A.R.; Zigler, A.

    2016-01-01

    Recent progress with wake-field acceleration has shown a great potential in providing high gradient acceleration fields, while the quality of the beams remains relatively poor. Precise knowledge of the beam size at the exit from the plasma and matching conditions for the externally injected beams are the key for improvement of beam quality. Betatron radiation emitted by the beam during acceleration in the plasma is a powerful tool for the transverse beam size measurement, being also non-intercepting. In this work we report on the technical solutions chosen at SPARC-LAB for such diagnostics tool, along with expected parameters of betatron radiation. - Highlights: • The betatron radiation parameters in SPARC-LAB wakefiled experiments were studied. • The differences with betatron radiation in other wake-field experiments were highlighted. • The solution for betatron radiation detection was investigated.

  8. Synchro-betatron resonance due to gap voltage asymmetry

    Energy Technology Data Exchange (ETDEWEB)

    Baartman, R

    1992-11-01

    RF cavities for synchrotrons are not in general axially symmetric. This can be due, for example, to the location of the input power coupling loop. It can cause the voltage on one side of the accelerating gap to be different from that on the other side. Associated with this asymmetry is an rf magnetic field which deflects a beam particle by an amount depending upon its rf phase. The deflection can accumulate if the betatron tune is situated on a synchrotron sideband of the integer resonance. We develop the theory for this resonance and apply it to the KAON Factory Booster and to the SSC LEB. We find that the upper limit on allowable voltage asymmetry across the beam pipe is 0.1% in both cases. (author) 5 refs., 1 tab.

  9. Formation of Field-reversed-Configuration Plasma with Punctuated-betatron-orbit Electrons

    International Nuclear Information System (INIS)

    Welch, D.R.; Cohen, S.A.; Genoni, T.C.; Glasser, A.H.

    2010-01-01

    We describe ab initio, self-consistent, 3D, fully electromagnetic numerical simulations of current drive and field-reversed-configuration plasma formation by odd-parity rotating magnetic fields (RMFo). Magnetic-separatrix formation and field reversal are attained from an initial mirror configuration. A population of punctuated-betatron-orbit electrons, generated by the RMFo, carries the majority of the field-normal azimuthal electrical current responsible for field reversal. Appreciable current and plasma pressure exist outside the magnetic separatrix whose shape is modulated by the RMFo phase. The predicted plasma density and electron energy distribution compare favorably with RMFo experiments.

  10. PRINCIPLE OF SKEW QUADRUPOLE MODULATION TO MEASURE BETATRON COUPLING

    International Nuclear Information System (INIS)

    LUO, Y.; PILAT, F.; ROSER, T.

    2004-01-01

    The measurement of the residual betatron coupling via skew quadrupole modulation is a new diagnostics technique that has been developed and tested at the Relativistic Heavy Ion Collider (RHIC) as a very promising method for the linear decoupling on the ramp. By modulating the strengths of different skew quadrupole families the two eigentunes are precisely measured with the phase lock loop system. The projections of the residual coupling coefficient onto the skew quadrupole coupling modulation directions are determined. The residual linear coupling could be corrected according to the measurement. An analytical solution for skew quadrupole modulation based on Hamiltonian perturbation approximation is given, and simulation code using smooth accelerator model is also developed. Some issues concerning the practical applications of this technique are discussed

  11. Iron-free betatrons - short radiation pulse generators for roentgenography of fast-going processes

    Energy Technology Data Exchange (ETDEWEB)

    Pavlovskij, A P; Zenkov, D I; Kuropatkin, Yu P; Mironenko, V D; Suvorov, V N [All-Russian Scientific Research Inst. of Experimental Physics, Sarov (Russian Federation)

    1997-12-31

    The possibilities of further increasing the current in high-current iron-free betatrons are studied. The efficiency of electron capture has been successfully increased by introducing local disturbances of the betatron magnetic field. At the optimum ratios of the disturbing and the betatron field, and at the optimum winding geometry as for the field disturbances and their attenuation rate, a multi-revolution electron capture has been achieved. The dependence of the circulating current on the injection energy was studied at the optimized facility with a porcelain accelerating chamber and a conducting cover. The experimental dependence is close to the calculated one. The maximum circulating current achieved was 28030 A which is the record value for circular accelerators. (J.U.). 1 tab., 5 figs., 2 refs.

  12. Inductive-pulsed power supplying system for a betatron electromagnet

    International Nuclear Information System (INIS)

    Otrubyannikov, Yu.A.; Safronov, A.S.

    1984-01-01

    Circuit of producing quasitriangular current pulses designed for the pulsed power supply system of betatron electromagnet is described. Introduction of additional winding into electromagnet provides circuit galvanic isolation, artificial commutation of basic circuit thyristors and inductive power input to the winding during thyristor commutation. The considered system is used for excitation of betatron electromagnet up to 18 MeV. Magnetic field energy equals 1100 Y. The maximal voltage in energy storage capacitor - 4.8 kV. Current amplitude in basic winding - 335 A. The number of loops in basic winding equals 80, in additional one - 32. Current pulse duration in electromagnet-3.8 ms. The system provides operation with controlled current pulse frequency from 0 up to 150 Hz. The maximal consumption power - 18 kW

  13. Tune shift and betatron modulations due to insertion devices in SPEAR

    International Nuclear Information System (INIS)

    Corbett, W.J.

    1989-12-01

    SPEAR will soon operate as a dedicated synchrotron radiation source with up to 5 beamlines fed from insertion devices. These magnets introduce additional focusing forces into the storage ring lattice which increase the vertical betatron tune and modulate the beam envelope in the vertical plane. The lattice simulation code 'GEMINI' is used to evaluate the tune shifts and estimate the degree of betatron modulation as each magnetic insertion device is brought up to full power. A program is recommended to correct the tunes with the FODO cell quadrupoles. 4 refs., 8 figs., 1 tab

  14. Dispersion and betatron matching into the linac

    International Nuclear Information System (INIS)

    Decker, F.J.; Adolphsen, C.; Corbett, W.J.; Emma, P.; Hsu, I.; Moshammer, H.; Seeman, J.T.; Spence, W.L.

    1991-05-01

    In high energy linear colliders, the low emittance beam from a damping ring has to be preserved all the way to the linac, in the linac and to the interaction point. In particular, the Ring-To-Linac (RTL) section of the SLAC Linear Collider (SLC) should provide an exact betatron and dispersion match from the damping ring to the linac. A beam with a non-zero dispersion shows up immediately as an increased emittance, while with a betatron mismatch the beam filaments in the linac. Experimental tests and tuning procedures have shown that the linearized beta matching algorithms are insufficient if the actual transport line has some unknown errors not included in the model. Also, adjusting quadrupole strengths steers the beam if it is offset in the quadrupole magnets. These and other effects have lead to a lengthy tuning process, which in the end improves the matching, but is not optimal. Different ideas will be discussed which should improve this matching procedure and make it a more reliable, faster and simpler process. 5 refs., 2 figs

  15. Betatron stochastic cooling in the Debuncher: Present and future

    International Nuclear Information System (INIS)

    Visnjic, V.

    1993-07-01

    A detailed study of the betatron stochastic cooling in the Debuncher is presented. First, a complete theoretical model including the emittance-dependent signal-to-noise ratio as well as time-dependent mixing is constructed. The emittance measurements in the Debuncher are described and it is shown that the model is in excellent agreement with the experimental data. The idea of gain shaping is proposed and it is shown that the gain shaping would improve the cooling of the beam. Several proposals for future improvements are studied and appraised, in particular, gain shaping, ramped η, and cryogenic and ''smart'' pickups and kickers. Finally, the demands which the Main Injector will impose on the Debuncher are analyzed and a design of the betatron stochastic cooling system for the Main Injector era is outlined

  16. Evaluation of the combined betatron and momentum cleaning in point 3 in terms of cleaning efficiency and energy deposition for the LHC Collimation upgrade

    CERN Document Server

    Lari, L; Boccone, V; Brugger, M; Cerutti, F; Ferrari, A; Rossi, A; Versaci, R; Vlachoudis, V; Wollmann, D; Mereghetti, A; Faus-Golfe, A

    2011-01-01

    The Phase I LHC Collimation System Upgrade could include moving part of the Betatron Cleaning from LHC Point 7 to Point 3 to improve both operation flexibility and intensity reach. In addition, the partial relocation of beam losses from the current Betatron cleaning region at Point 7 will mitigate the risks of Single Event Upsets to equipment installed in adjacent and partly not sufficient shielded areas. The combined Betatron and Momentum Cleaning at Point 3 implies that new collimators have to be added as well as to implement a new collimator aperture layout. This paper shows the whole LHC Collimator Efficiency variation with the new layout at different beam energies. As part of the evaluation, energy deposition distribution in the IR3 region give indications about the effect of this new implementations not only on the collimators themselves but also on the other beam line elements as well as in the IR3 surrounding areas.

  17. Preliminary Studies Of A Phase Modulation Technique For Measuring Chromaticity

    International Nuclear Information System (INIS)

    Tan, C.-Y.

    2006-01-01

    The classical method for measuring chromaticity is to slowly modulate the RF frequency and then measure the betatron tune excursion. The technique that is discussed in this paper instead modulates the phase of the RF and then the chromaticity is obtained by phase demodulating the betatron tune. This technique requires knowledge of the betatron frequency in real time in order for the phase to be demodulated. Fortunately, the Tevatron has a tune tracker based on the phase locked loop principle which fits this requirement. A preliminary study with this technique has showed that it is a promising method for doing continuous chromaticity measurement and raises the possibility of doing successful chromaticity feedback with it

  18. Characteristics of a betatron core for extraction in a proton-ion medical synchrotron

    CERN Document Server

    Badano, L

    1997-01-01

    Medical synchrotrons for radiation therapy require a very stable extraction of the beam over a period of about one second. The techniques for applying resonant extraction to achieve this long spill can be classified into two groups, those that move the resonance and those that move the beam. The latter has the great advantage of keeping all lattice functions, and hence the resonance conditions, constant. The present report examines the possibility of using a betatron core to accelerate the waiting ion beam by induction into the resonance. The working principle, the proposed characteristics and the expected performances of this device are discussed. The betatron core is a smooth high-inductance device compared to the small quadrupole lenses that are normally used to move the resonance and is therefore better suited to delivering a very smooth spill. The large stored energy in a betatron core compared to a small quadrupole is also a safety feature since it responds less quickly to transients that could send lar...

  19. Linear theory of beam depolarization due to vertical betatron motion

    International Nuclear Information System (INIS)

    Chao, A.W.; Schwitters, R.F.

    1976-06-01

    It is well known that vertical betatron motion in the presence of quantum fluctuations leads to some degree of depolarization of a transversely polarized beam in electron-positron storage rings even for energies away from spin resonances. Analytic formulations of this problem, which require the use of simplifying assumptions, generally have shown that there exist operating energies where typical storage rings should exhibit significant beam polarization. Due to the importance of beam polarization in many experiments, we present here a complete calculation of the depolarization rate to lowest order in the perturbing fields, which are taken to be linear functions of the betatron motion about the equilibrium orbit. The results are applicable to most high energy storage rings. Explicit calculations are given for SPEAR and PEP. 7 refs., 8 figs

  20. Chromaticity tracking using a phase modulation technique

    International Nuclear Information System (INIS)

    Tan, C.Y.; Fermilab

    2007-01-01

    In the classical chromaticity measurement technique, chromaticity is measured by measuring the change in betatron tune as the RF frequency is varied. This paper will describe a novel way of measuring chromaticity: we will phase modulate the RF with a known sine wave and then phase demodulate the betatron frequency. The result is a line in Fourier space which corresponds to the frequency of our sine wave modulation. The peak of this sine wave is proportional to chromaticity. For this technique to work, a tune tracker PLL system is required because it supplies the betatron carrier frequency. This method has been tested in the Tevatron and we will show the results here

  1. Photoneutron source based on a compact 10 MeV betatron

    International Nuclear Information System (INIS)

    Bell, Z.W.; Chaklov, V.L.; Golovkov, V.M.

    1998-01-01

    Accelerator-based photoneutron sources have enjoyed wide use and offer the advantages of long term stability, ease of control and absence of radioactive materials. The authors report here measurements of the yield of photoneutrons from a neutron generator using a compact betatron (466 kg total weight, 900 by 560 by 350 mm betatron dimensions) at the Institute of Introscopy of the Tomsk Polytechnic University. Electrons were accelerated to energies up to 10 MeV and produced a bremsstrahlung beam with a dose rate of 0.16 Gy/min (at 10 MeV, 1 meter from the bremsstrahlung target) to irradiate LiD, Be, depleted U, and Pb neutron-producing targets. The angular distributions of photoneutrons produced by bremsstrahlung beams were measured with a long counter and integrated to determine neutron yield. In addition, neutron time of flight spectra were recorded from all targets using a 15 meter flight path perpendicular to the photon beam. The maximum observed yields were 5.2 x 10 4 n/rad/gram target obtained with LiD, 1.7 x 10 4 n/rad/gram from Be, 3.3 x 10 3 n/rad/gram from U, and 7.5 x 10 2 n/rad/gram from Pb. Optimization of target dimensions, shape, and positioning is expected to increase the yield from the LiD target by a factor of 35. With the increased yield, this compact betatron-based system could find application in the interrogation of waste containers for fissile material

  2. Measurement of angularly dependent spectra of betatron gamma-rays from a laser plasma accelerator with quadrant-sectored range filters

    Energy Technology Data Exchange (ETDEWEB)

    Jeon, Jong Ho, E-mail: jhjeon07@ibs.re.kr; Nakajima, Kazuhisa, E-mail: naka115@dia-net.ne.jp; Rhee, Yong Joo; Pathak, Vishwa Bandhu; Cho, Myung Hoon; Shin, Jung Hun; Yoo, Byung Ju; Jo, Sung Ha; Shin, Kang Woo [Center for Relativistic Laser Science, Institute for Basic Science (IBS), Gwangju 61005 (Korea, Republic of); Kim, Hyung Taek; Sung, Jae Hee; Lee, Seong Ku; Choi, Il Woo [Center for Relativistic Laser Science, Institute for Basic Science (IBS), Gwangju 61005 (Korea, Republic of); Advanced Photonics Research Institute, GIST, Gwangju 61005 (Korea, Republic of); Hojbota, Calin; Bae, Lee Jin; Jung, Jaehyung; Cho, Min Sang; Cho, Byoung Ick; Nam, Chang Hee [Center for Relativistic Laser Science, Institute for Basic Science (IBS), Gwangju 61005 (Korea, Republic of); Department of Physics and Photon Science, GIST, Gwangju 61005 (Korea, Republic of)

    2016-07-15

    Measurement of angularly dependent spectra of betatron gamma-rays radiated by GeV electron beams from laser wakefield accelerators (LWFAs) are presented. The angle-resolved spectrum of betatron radiation was deconvolved from the position dependent data measured for a single laser shot with a broadband gamma-ray spectrometer comprising four-quadrant sectored range filters and an unfolding algorithm, based on the Monte Carlo code GEANT4. The unfolded gamma-ray spectra in the photon energy range of 0.1–10 MeV revealed an approximately isotropic angular dependence of the peak photon energy and photon energy-integrated fluence. As expected by the analysis of betatron radiation from LWFAs, the results indicate that unpolarized gamma-rays are emitted by electrons undergoing betatron motion in isotropically distributed orbit planes.

  3. Automatic Correction of Betatron Coupling in the LHC Using Injection Oscillations

    CERN Document Server

    Persson, T; Jacquet, D; Kain, V; Levinsen, Y; McAteer, M-J; Maclean, E; Skowronski, P; Tomas, R; Vanbavinckhove, G; Miyamoto, R

    2013-01-01

    The control of the betatron coupling at injection and during the energy ramp is critical for the safe operation of the tune feedback and for the dynamic aperture. In the LHC every fill is preceded by the injection of a pilot bunch with low intensity. Using the injection oscillations from the pilot bunch we are able to measure the coupling at each individual BPM. The measurement is used to calculate a global coupling correction. The correction is based on the use of two orthogonal knobs which correct the real and imaginary part of the difference resonance term f1001, respectively. This method to correct the betatron coupling has been proven successful during the normal operation of the LHC. This paper presents the method used to calculate the corrections and its performance.

  4. A broadband gamma-ray spectrometry using novel unfolding algorithms for characterization of laser wakefield-generated betatron radiation

    Energy Technology Data Exchange (ETDEWEB)

    Jeon, Jong Ho, E-mail: jhjeon07@ibs.re.kr; Nakajima, Kazuhisa, E-mail: naka115@dia-net.ne.jp; Pathak, Vishwa Bandhu; Cho, Myung Hoon; Yoo, Byung Ju; Shin, Kang Woo [Center for Relativistic Laser Science, Institute for Basic Science (IBS), Gwangju 500-712 (Korea, Republic of); Kim, Hyung Taek; Sung, Jae Hee; Lee, Seung Ku; Choi, Il Woo [Center for Relativistic Laser Science, Institute for Basic Science (IBS), Gwangju 500-712 (Korea, Republic of); Advanced Photonics Research Institute, GIST, Gwangju 500-712 (Korea, Republic of); Rhee, Yong Joo [Nuclear Data Center, Korea Atomic Energy Research Institute, Daejeon 305-353 (Korea, Republic of); Shin, Jung Hun; Jo, Sung Ha [Advanced Photonics Research Institute, GIST, Gwangju 500-712 (Korea, Republic of); Hojbota, Calin; Cho, Byeoung Ick; Nam, Chang Hee [Center for Relativistic Laser Science, Institute for Basic Science (IBS), Gwangju 500-712 (Korea, Republic of); Department of Physics and Photon Science, GIST, Gwangju 500-712 (Korea, Republic of)

    2015-12-15

    We present a high-flux, broadband gamma-ray spectrometry capable of characterizing the betatron radiation spectrum over the photon energy range from 10 keV to 20 MeV with respect to the peak photon energy, spectral bandwidth, and unique discrimination from background radiations, using a differential filtering spectrometer and the unfolding procedure based on the Monte Carlo code GEANT4. These properties are experimentally verified by measuring betatron radiation from a cm-scale laser wakefield accelerator (LWFA) driven by a 1-PW laser, using a differential filtering spectrometer consisting of a 15-filter and image plate stack. The gamma-ray spectra were derived by unfolding the photostimulated luminescence (PSL) values recorded on the image plates, using the spectrometer response matrix modeled with the Monte Carlo code GEANT4. The accuracy of unfolded betatron radiation spectra was assessed by unfolding the test PSL data simulated with GEANT4, showing an ambiguity of less than 20% and clear discrimination from the background radiation with less than 10%. The spectral analysis of betatron radiation from laser wakefield-accelerated electron beams with energies up to 3 GeV revealed radiation spectra characterized by synchrotron radiation with the critical photon energy up to 7 MeV. The gamma-ray spectrometer and unfolding method presented here facilitate an in-depth understanding of betatron radiation from LWFA process and a novel radiation source of high-quality photon beams in the MeV regime.

  5. Betatron activation analysis of cupriferous flotation pulp

    International Nuclear Information System (INIS)

    Kaminski, R.; Matenko, J.; Mencel, J.; Janiczek, J.; Kielsznia, J.

    1974-01-01

    A method of copper determination in cupriferous flotation pulp by photo-activation analysis using betatron and another equipments of existent ''analytical line'' intended for copper determination in dry samples has been described. An activation has been achieved with 14.9 MeV γ-photons. The excitation activity was investigated by using two scintillation detectors and a fast coincidence circuit with resolution time 80 ns. The precision of method was determined as +- 4.25% in 0.95 confidence level for pulp with concentration 5% Cu and +- 24% for 0.06% Cu. (author)

  6. Long-wavelength negative mass instabilities in high current betatrons

    International Nuclear Information System (INIS)

    Godfrey, B.B.; Hughes, T.P.

    1985-01-01

    Growth rates of negative mass instabilities in conventional and modified betatrons are calculated by analytic methods and by performing three-dimensional particle simulations. In contrast to earlier work, toroidal corrections to the field equations are included in the analytic model. As a result, good agreement with numerical simulations is obtained. The simulations show that the nonlinear development of the instabilities can seriously disrupt the beam

  7. The effects of betatron motion on the preservation of FEL microbunching

    Energy Technology Data Exchange (ETDEWEB)

    Geloni, Gianluca [European XFEL GmbH, Hamburg (Germany); Kocharyan, Vitali; Saldin, Evgeni [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2011-05-15

    In some options for circular polarization control at X-ray FELs, a helical radiator is placed a few ten meters distance behind the baseline undulator. If the microbunch structure induced in the baseline (planar) undulator can be preserved, intense coherent radiation is emitted in the helical radiator. The effects of betatron motion on the preservation of micro bunching in such in-line schemes should be accounting for. In this paper we present a comprehensive study of these effects. It is shown that one can work out an analytical expression for the debunching of an electron beam moving in a FODO lattice, strictly valid in the asymptote for a FODO cell much shorter than the betatron function. Further on, numerical studies can be used to demonstrate that the validity of such analytical expression goes beyond the abovementioned asymptote, and can be used in much more a general context. Finally, a comparison with Genesis simulations is given. (orig.)

  8. Correction of dispersion and the betatron functions in the CEBAF accelerator

    International Nuclear Information System (INIS)

    Lebedev, V.A.; Bickley, M.; Schaffner, S.; Zeijts, J. van; Krafft, G.A.; Watson, C.

    1996-01-01

    During the commissioning of the CEBAF accelerator, correction of dispersion and momentum compaction, and, to a lesser extent, transverse transfer matrices were essential for robust operation. With changing machine conditions, repeated correction was found necessary. To speed the diagnostic process the authors developed a method which allows one to rapidly track the machine optics. The method is based on measuring the propagation of 30 Hz modulated betatron oscillations downstream of a point of perturbation. Compared to the usual methods of dispersion or difference orbit measurement, synchronous detection of the beam displacement, as measured by beam position monitors, offers significantly improved speed and accuracy of the measurements. The beam optics of the accelerator was altered to decrease lattice sensitivity at critical points and to simplify control of the betatron function match. The calculation of the Courant-Snyder invariant from signals of each pair of nearby beam position monitors has allowed one to perform on-line measurement and correction of the lattice properties

  9. The effects of betatron motion on the preservation of FEL microbunching

    International Nuclear Information System (INIS)

    Geloni, Gianluca; Kocharyan, Vitali; Saldin, Evgeni

    2011-05-01

    In some options for circular polarization control at X-ray FELs, a helical radiator is placed a few ten meters distance behind the baseline undulator. If the microbunch structure induced in the baseline (planar) undulator can be preserved, intense coherent radiation is emitted in the helical radiator. The effects of betatron motion on the preservation of micro bunching in such in-line schemes should be accounting for. In this paper we present a comprehensive study of these effects. It is shown that one can work out an analytical expression for the debunching of an electron beam moving in a FODO lattice, strictly valid in the asymptote for a FODO cell much shorter than the betatron function. Further on, numerical studies can be used to demonstrate that the validity of such analytical expression goes beyond the abovementioned asymptote, and can be used in much more a general context. Finally, a comparison with Genesis simulations is given. (orig.)

  10. Experimental investigation of a small-sized betatron with superposed magnetization

    International Nuclear Information System (INIS)

    Kas'yanov, V.A.; Rychkov, M.V.; Filimonov, A.A.; Furman, Eh.G.; Chakhlov, V.L.; Chertov, A.S.; Shtejn, M.M.

    2001-01-01

    The aim of the paper is to study possibilities of small-sized betatrons (SSB) with direct current superposed magnetization (DSM). It is shown that DSM permits to decrease the SSB weight and cost of the electromagnet and capacitor storage and to shape the prolonged beam dump. It is noted that the DSM realization has the most expediency in SSB operating in a short-time mode [ru

  11. Betatron emission as a diagnostic for injection and acceleration mechanisms in laser plasma accelerators

    International Nuclear Information System (INIS)

    Corde, S; Thaury, C; Phuoc, K Ta; Lifschitz, A; Lambert, G; Lundh, O; Brijesh, P; Sebban, S; Rousse, A; Faure, J; Malka, V; Arantchuk, L

    2012-01-01

    Betatron x-ray emission in laser plasma accelerators is a promising compact source that may be an alternative to conventional x-ray sources, based on large scale machines. In addition to its potential as a source, precise measurements of betatron emission can reveal crucial information about relativistic laser–plasma interaction. We show that the emission length and the position of the x-ray emission can be obtained by placing an aperture mask close to the source, and by measuring the beam profile of the betatron x-ray radiation far from the aperture mask. The position of the x-ray emission gives information on plasma wave breaking and hence on the laser non-linear propagation. Moreover, the measurement of the longitudinal extension helps one to determine whether the acceleration is limited by pump depletion or dephasing effects. In the case of multiple injections, it is used to retrieve unambiguously the position in the plasma of each injection. This technique is also used to study how, in a capillary discharge, the variations of the delay between the discharge and the laser pulse affect the interaction. The study reveals that, for a delay appropriate for laser guiding, the x-ray emission only occurs in the second half of the capillary: no electrons are injected and accelerated in the first half. (paper)

  12. Successful betatron acceleration of kiloampere electron rings in RECE-Christa

    International Nuclear Information System (INIS)

    Taggart, D.P.; Parker, M.R.; Hopman, H.J.; Jayakumar, R.; Fleischmann, H.H.

    1984-01-01

    This paper reports on betatron acceleration experiments using the space-charge-neutralized electron rings in the RECE-Christa device. Magnetic probe and x-ray-absorption measurements indicate that electron ring currents of up to 2 kA were accelerated to 3.3 +- 0.3 MeV without indication of instabilities. A similar neutralization and acceleration method also appears applicable to electron rings generated in B/sub theta/-free configurations

  13. Betatron coupling: Merging Hamiltonian and matrix approaches

    Directory of Open Access Journals (Sweden)

    R. Calaga

    2005-03-01

    Full Text Available Betatron coupling is usually analyzed using either matrix formalism or Hamiltonian perturbation theory. The latter is less exact but provides a better physical insight. In this paper direct relations are derived between the two formalisms. This makes it possible to interpret the matrix approach in terms of resonances, as well as use results of both formalisms indistinctly. An approach to measure the complete coupling matrix and its determinant from turn-by-turn data is presented. Simulations using methodical accelerator design MAD-X, an accelerator design and tracking program, were performed to validate the relations and understand the scope of their application to real accelerators such as the Relativistic Heavy Ion Collider.

  14. Kinetic description of self-field effects on laser and betatron emission in wiggler-pumped ion-channel free electron lasers

    International Nuclear Information System (INIS)

    Alimohamadi, M; Mehdian, H; Hasanbeigi, A

    2011-01-01

    The effects of self-fields on the free electron lasers (FELs) with a helical wiggler and ion-channel guiding are considered. The steady-state orbits for a single electron in this configuration are obtained. The rate of change of axial velocity with energy, the characteristic function Φ, is derived and studied numerically. A kinetic approach has been used to get the effects of self-field on the FEL and betatron gain formula in the low-gain-pre-pass limit. It is shown that betatron gain is smaller than FEL gain. We also found a gain decrement (enhancement), arising from diamagnetism (paramagnetism) generated by the self-magnetic field for group I (group II) orbits. It is interesting that the gain enhancement is found for the non-relativistic part of group II orbits. The FEL gain and betatron gain have also been investigated for different relativistic factors γ.

  15. Landau damping due to tune spreads in betatron amplitude and momentum

    International Nuclear Information System (INIS)

    Lee, S.Y.; Tran, P.; Weng, W.T.

    1989-01-01

    Due to the large space charge transverse impedance in a low energy synchrotron, the coherent tune shift causes the Landau damping to be ineffective in damping the transverse coherent motion. We analyze the effect of Landau damping that is caused by the tune spreads of the betatron amplitude (space charge and/or octupole) and momentum. We find that the Landau damping becomes more significant in our two dimensional analysis. 5 refs

  16. High-speed radiography and x-ray cinematography by high-current betatrons

    International Nuclear Information System (INIS)

    Akimochkin, Yu.V.; Akulov, G.V.; Leunov, F.G.; Moskalev, V.A.; Ryabukhin, V.L.

    1979-01-01

    The paper provides a description of an equipment system comprising a pair of 25 MeV high-current betatrons and an X-ray drum-type cinecamera for high-speed radiography and X-ray cinematography for use when studying dynamics of objects moving at a rate of 0.5 - 3.0 km/s as well as in X-ray cinematography of processes at a rate of up to 1 m/s. (author)

  17. Coherent betatron instability driven by electrostatic separators: Stability analysis of the Tevatron

    International Nuclear Information System (INIS)

    Harfoush, F.A.; Bogacz, S.A.

    1989-03-01

    This paper outlines possible intensity limits due to the coherent betatron motion for the upgraded Tevatron with the electrostatic separators. Numerical simulation shows that this new vacuum chamber structure dominates the high frequency part of the coupling impedance spectrum and more likely will excite a slow head-tail instability. A simple stability analysis yields the characteristic growth-time of the unstable modes. 4 refs., 4 figs., 1 tab

  18. Laser-wakefield accelerators for medical phase contrast imaging: Monte Carlo simulations and experimental studies

    Science.gov (United States)

    Cipiccia, S.; Reboredo, D.; Vittoria, Fabio A.; Welsh, G. H.; Grant, P.; Grant, D. W.; Brunetti, E.; Wiggins, S. M.; Olivo, A.; Jaroszynski, D. A.

    2015-05-01

    X-ray phase contrast imaging (X-PCi) is a very promising method of dramatically enhancing the contrast of X-ray images of microscopic weakly absorbing objects and soft tissue, which may lead to significant advancement in medical imaging with high-resolution and low-dose. The interest in X-PCi is giving rise to a demand for effective simulation methods. Monte Carlo codes have been proved a valuable tool for studying X-PCi including coherent effects. The laser-plasma wakefield accelerators (LWFA) is a very compact particle accelerator that uses plasma as an accelerating medium. Accelerating gradient in excess of 1 GV/cm can be obtained, which makes them over a thousand times more compact than conventional accelerators. LWFA are also sources of brilliant betatron radiation, which are promising for applications including medical imaging. We present a study that explores the potential of LWFA-based betatron sources for medical X-PCi and investigate its resolution limit using numerical simulations based on the FLUKA Monte Carlo code, and present preliminary experimental results.

  19. Model-independent analysis of the Fermilab Tevatron turn-by-turn beam position monitor measurements

    Science.gov (United States)

    Petrenko, A. V.; Valishev, A. A.; Lebedev, V. A.

    2011-09-01

    Coherent transverse beam oscillations in the Tevatron were analyzed with the model-independent analysis (MIA) technique. This allowed one to obtain the model-independent values of coupled betatron amplitudes, phase advances, and dispersion function around the ring from a single dipole kick measurement. In order to solve the MIA mode mixing problem which limits the accuracy of determination of the optical functions, we have developed a new technique of rotational MIA mode untangling. The basic idea is to treat each beam position monitor (BPM) as two BPMs separated in a ring by exactly one turn. This leads to a simple criterion of MIA mode separation: the betatron phase advance between any BPM and its counterpart shifted by one turn should be equal to the betatron tune and therefore should not depend on the BPM position in the ring. Furthermore, we describe a MIA-based technique to locate vibrating magnets in a storage ring.

  20. Model-independent analysis of the Fermilab Tevatron turn-by-turn beam position monitor measurements

    Directory of Open Access Journals (Sweden)

    A. V. Petrenko

    2011-09-01

    Full Text Available Coherent transverse beam oscillations in the Tevatron were analyzed with the model-independent analysis (MIA technique. This allowed one to obtain the model-independent values of coupled betatron amplitudes, phase advances, and dispersion function around the ring from a single dipole kick measurement. In order to solve the MIA mode mixing problem which limits the accuracy of determination of the optical functions, we have developed a new technique of rotational MIA mode untangling. The basic idea is to treat each beam position monitor (BPM as two BPMs separated in a ring by exactly one turn. This leads to a simple criterion of MIA mode separation: the betatron phase advance between any BPM and its counterpart shifted by one turn should be equal to the betatron tune and therefore should not depend on the BPM position in the ring. Furthermore, we describe a MIA-based technique to locate vibrating magnets in a storage ring.

  1. Photoneutron source based on a compact 10 MeV betatron

    International Nuclear Information System (INIS)

    Chakhlov, V.L.; Bell, Z.W.; Golovkov, V.M.; Shtein, M.M.

    1999-01-01

    Accelerator-based photoneutron sources have enjoyed wide use and offer the advantages of long term stability, ease of control and absence of radioactive materials. We report here measurements of the yield of photoneutrons from a neutron generator using a compact betatron. Electrons were accelerated to energies up to 10 MeV and produced a bremsstrahlung beam with a dose rate of 0.16 Gy/min (at 10 MeV, 1 m from the bremsstrahlung target) to irradiate LiD, Be, depleted U, and Pb neutron-producing targets. The angular distributions of photoneutrons produced by bremsstrahlung beams were measured with a 'long' counter and integrated to determine neutron yield. In addition, neutron time of flight spectra were recorded from all targets using a 15.5 m flight path perpendicular to the photon beam. The maximum observed yields were 4.6x10 7 n/s obtained with 1 kg of LiD, 5.7x10 7 n/s from a 3.3 kg Be block, 6.2x10 6 n/s from 1.5 kg of depleted U, and 7.0x10 6 n/s from 10.7 kg of Pb. Optimization of target dimensions, shape, and positioning is expected to increase the yield from the LiD target by a factor of 35, while optimization of the other targets is expected to yield at most a factor of 10. With the increased yield and a deuteride target, this compact betatron-based system could find application in the interrogation of waste containers for fissile material

  2. Therapy by stationary photon fields from a 42 MeV betatron using wedge filters

    International Nuclear Information System (INIS)

    Wicke, L.; Kaercher, K.H.; Naesiger, H.; Prokosch, E.; Vienna Univ.

    1975-01-01

    The dose distribution in photon beams from a 42 MeV betatron using wedge filters of lead with different angles of slope is described. The wedge coefficient to be considered at a field size of 10 x 10 cm is given. The scope for isodoses modified by wedge filters is discussed with regard to stationary-field photon therapy. (orig.) [de

  3. The production of radioisotopes with a betatron using an internal bombarding technique; Production de radioisotopes par bombardement interne dans un betatron; Proizvodstvo radioizotopov s pomoshch'yu betatrona s ispol'zovaniem metoda vnutrennej bombardirovki; Obtencion de radioisotopos por bombardeo interno en el betatron

    Energy Technology Data Exchange (ETDEWEB)

    Morinaga, H [Department of Physics, Tohoku University, Sendai (Japan)

    1962-01-15

    A new technique for producing radioisotopes of high specific activity with a betatron has been developed and is being used successfully. Materials to be activated are placed inside the doughnut at the end of a blind cylinder inserted from outside; thus samples are bombarded under one atmosphere just behind the bremsstrahlung target where the radiation intensity is extremely high. The saturation activity of Cu{sup 62} produced on a small piece of copper exceeded 1 mc, and the highest specific activity obtainable was approximately 500 times that produced in a conventional arrangement. So far, this internal-target technique has been used only for nuclear spectroscopy work; eight new species of radioactive isotopes (Co{sup 63}, Ga{sup 75}, As{sup 81}, In{sup 121}, In{sup 123}, Tm{sup 173}, Tm{sup 175} and Ac{sup 231}) have been identified and several new isomers have been found. The feasibility of this bombarding technique opens neiv possibilities, since medical, industrial or research betatrons may now be used, for isotope production. Short-lived isotopes are often more convenient in various applications because of their fast decay and high-energy radiation, and they may be made readily without any special skill. (author) [French] On a mis au point et utilise avec succes line technique nouvelle pour la production de radioisotopes d'activite specifique elevee dans un betatron. Les matieres a activer sont placees a l'interieur d'un tube toroidal, a l'extremite d'un cylindre a ouverture unique introduit de l'exterieur; les echantillons se trouvent ainsi bombardes, sous une atmosphere, juste derriere la cible de rayonnement de freinage, a l'endroit ou l'intensite du rayonnement est extremement elevee. L'activite de saturation du {sup 62}Cu produite sur de petits morceaux de cuivre depassait 1 millicurie et l'activite specifique la plus elevee que l'on ait pu obtenir egalait environ 500 fois l'activite produite dans un dispositif classique. Jusqu'a present, cette technique

  4. Thyristor current-pulse generator for betatron electromagnet with independent low-voltage supply

    International Nuclear Information System (INIS)

    Baginskii, B.A.; Makarevich, V.N.; Shtein, M.M.

    1989-01-01

    A thyristor generator is described that produces unipolar current pulses in the winding of a betatron electromagnet. The voltage on the electro-magnet is increased and the shape of the current pulses is improved by use of an intermediate inductive storage device. The current pulses have a duration of 11 msec, an amplitude of 190 A, and a repetition frequency of 50 Hz. The maximum magnetic-field energy is 450 J, the voltage on the electromagnet winding is 1.5 kV, and the supply voltage is 27 V

  5. Approximate method for calculating heat conditions in the magnetic circuits of transformers and betatrons

    International Nuclear Information System (INIS)

    Loginov, V.S.

    1986-01-01

    A technique for engineering design of two-dimensional stationary temperature field of rectangular cross section blending pile with inner heat release under nonsymmetrical cooling conditions is suggested. Area of its practical application is determined on the basis of experimental data known in literature. Different methods for calculating temperature distribution in betatron magnetic circuit are compared. Graph of maximum temperature calculation error on the basis of approximated expressions with respect to exact solution is given

  6. Bruno Touschek: From Betatrons to Electron-Positron Colliders

    Science.gov (United States)

    Bernardini, Carlo; Pancheri, Giulia; Pellegrini, Claudio

    Bruno Touschek’s life as a physicist spanned the period from World War II to the 1970s. He was a key figure in the developments of electron-positron colliders and storage rings, and made important contributions to theoretical high energy physics. Storage rings, initially developed for high energy physics, are being widely used in many countries as synchrotron radiation sources and are a tool for research in physics, chemistry, biology, environmental sciences and cultural heritage studies. We describe Touschek’s life in Austria, where he was born, in Germany, where he participated in the construction of a betatron during WWII, and in Italy, where he proposed and led to completion the first electron-positron storage ring in 1960, in Frascati. We highlight how his central European culture influenced his lifestyle and work, and his main contributions to physics, such as the discovery of the Touschek effect and beam instabilities in the larger storage ring ADONE.

  7. Betatron tomography with the use of non-linear backprojection techniques

    International Nuclear Information System (INIS)

    Baranov, V.A.; Temnik, A.K.; Chakhlov, V.L.; Chekalin, A.S.

    1995-01-01

    The testing of heavy components under non-steady-state condition (at erection and building sites, at jigs, for testing of welded joints and valving of oil and gas pipelines, power and boiler plants repair, building construction and for testing of castings and welded joints of large thickness) traditionally belongs to most pressing NDT problems. One of essential prerequisites for success at this point was the elaboration of appropriate high energy radiation sources, in particular small size pulse betatrons like MIB-4 and MIB-6 with the energy 4 and 6 MeV. Now, taking into account the new possibilities of tomography, the adaptation of fresh methods of cross-sectional visualisation (like non-linear tomosynthesis) to this conventional problem-solving area is of special interest. (orig./RHM)

  8. Tuning the arcs of the SLAC linear collider

    International Nuclear Information System (INIS)

    Fieguth, T.; Bambade, P.; Barklow, T.; Brown, K.L.; Bulos, F.; Burke, D.L.; Fischer, G.E.; Hutton, A.; Jung, C.; Kheifets, S.A.; Komamiya, S.; Mattison, T.; Murray, J.J.; Phinney, N.; Ritson, D.M.; Sands, M.; Sheppard, J.C.; Spence, W.; Toge, N.; Weinstein, A.; Haissinski, J.; Placidi, M.

    1988-01-01

    New experience with the operation of the SLC Arcs is described. Each of these Arcs consists of sequential second-order achromats. Initial measurements showed that the betatron phase advances were systematically offset from the design values. This effect, combined with the abrupt rolls of the achromats needed to follow the local terrain, led to strong cross-plane coupling and to growth of the betatron oscillations. The methods and modifications developed to establish proper operation of the Arcs are described in this paper

  9. Study of the Betatron and Compton X-ray sources produced in laser wakefield acceleration of electrons

    International Nuclear Information System (INIS)

    Ferri, Julien

    2016-01-01

    An ultra-short and ultra-intense laser pulse propagating in a low-density gas can accelerate in its wake a part of the electrons ionized from the gas to relativistic energies of a few hundreds of MeV over distances of a few millimeters only. During their acceleration, as a consequence of their transverse motion, these electrons emit strongly collimated X-rays in the forward direction, which are called betatron radiations. The characteristics of this source turn it into an interesting tool for high-resolution imagery.In this thesis, we explore three different axis to work on this source using simulations on the Particles-In-Cells codes CALDER and CALDER-Circ. We first study the creation of a betatron X-ray source with kilo-joule and pico-second laser pulses, for which duration and energy are then much higher than usual in this domain. In spite of the unusual laser parameters, we show that X-ray sources can still be generated, furthermore in two different regimes.In a second study, the generally observed discrepancies between experiments and simulations are investigated. We show that the use of realistic laser profiles instead of Gaussian ones in the simulations strongly degrades the performances of the laser-plasma accelerator and of the betatron source. Additionally, this leads to a better qualitative and quantitative agreement with the experiment. Finally, with the aim of improving the X-ray emission, we explore several techniques based on the manipulation of the plasma density profile used for acceleration. We find that both the use of a transverse gradient and of a density step increases the amplitude of the electrons transverse motions, and then increases the radiated energy. Alternatively, we show that this goal can also be achieved through the transition from a laser wakefield regime to a plasma wakefield regime induced by an increase of the density. The laser wakefield optimizes the electron acceleration whereas the plasma wakefield favours the X

  10. Optimization of the Phase Advance Between RHIC Interaction Points

    CERN Document Server

    Tomas, Rogelio

    2005-01-01

    We consider the scenario of having two identical Interaction Points (IPs) in the Relativistic Heavy Ion Collider (RHIC). The strengths of beam-beam resonances strongly depend on the phase advance between these two IPs and therefore certain phase advances could improve beam lifetime and luminosity. We compute the dynamic aperture as function of the phase advance between these IPs to find the optimum settings. The beam-beam interaction is treated in the weak-strong approximation and a complete non-linear model of the lattice is used. For the current RHIC proton working point (0.69,0.685) the design lattice is found to have the optimum phase advance. However this is not the case for other working points.

  11. Advanced Gouy phase high harmonics interferometer

    Science.gov (United States)

    Mustary, M. H.; Laban, D. E.; Wood, J. B. O.; Palmer, A. J.; Holdsworth, J.; Litvinyuk, I. V.; Sang, R. T.

    2018-05-01

    We describe an extreme ultraviolet (XUV) interferometric technique that can resolve ∼100 zeptoseconds (10‑21 s) delay between high harmonic emissions from two successive sources separated spatially along the laser propagation in a single Gaussian beam focus. Several improvements on our earlier work have been implemented in the advanced interferometer. In this paper, we report on the design, characterization and optimization of the advanced Gouy phase interferometer. Temporal coherence for both atomic argon and molecular hydrogen gases has been observed for several harmonic orders. It has been shown that phase shift of XUV pulses mainly originates from the emission time delay due to the Gouy phase in the laser focus and the observed interference is independent of the generating medium. This interferometer can be a useful tool for measuring the relative phase shift between any two gas species and for studying ultrafast dynamics of their electronic and nuclear motion.

  12. Demonstration of no feasibility of a crystalline beam in a Betatron Magnet II

    International Nuclear Information System (INIS)

    Ruggiero, A.G.

    1993-01-01

    This paper investigates the feasibility of a Crystalline Beam in a weak-focusing Betatron Magnet. The curvature effect due to the bending magnet is also investigated. The case of circular one- dimensional string of electrically-charged particles is examined. It is found that the motion is unstable due to the dependence of the precession movement with the radial displacement. That is a form of negative-mass instability which can be avoided with an alternating-focussing structure. The calculation of the particle-particle interaction as well as of the forces due to the external magnetic field is done directly in the laboratory frame

  13. Computational advances in transition phase analysis

    International Nuclear Information System (INIS)

    Morita, K.; Kondo, S.; Tobita, Y.; Shirakawa, N.; Brear, D.J.; Fischer, E.A.

    1994-01-01

    In this paper, historical perspective and recent advances are reviewed on computational technologies to evaluate a transition phase of core disruptive accidents in liquid-metal fast reactors. An analysis of the transition phase requires treatment of multi-phase multi-component thermohydraulics coupled with space- and energy-dependent neutron kinetics. Such a comprehensive modeling effort was initiated when the program of SIMMER-series computer code development was initiated in the late 1970s in the USA. Successful application of the latest SIMMER-II in USA, western Europe and Japan have proved its effectiveness, but, at the same time, several areas that require further research have been identified. Based on the experience and lessons learned during the SIMMER-II application through 1980s, a new project of SIMMER-III development is underway at the Power Reactor and Nuclear Fuel Development Corporation (PNC), Japan. The models and methods of SIMMER-III are briefly described with emphasis on recent advances in multi-phase multi-component fluid dynamics technologies and their expected implication on a future reliable transition phase analysis. (author)

  14. Betatron-collimation Studies for Heavy Ions in the FCC-hh

    CERN Multimedia

    Logothetis Agaliotis, Efstathios

    2018-01-01

    One of the biggest challenges in the design of the FCC-hh is the collimation system. From LHC experience it is known that a collimation system optimized for proton cleaning has a significantly reduced efficiency for heavy ions. The study presented in this contribution evaluates the betatron-collimation efficiency for the heavy-ion operation with lead nuclei at a beam energy of 50 Z TeV in the system designed for proton operation. The fragmentation processes of the main beam particles in the primary collimator are simulated with FLUKA and fragments are individually tracked with SixTrack until being lost in the downstream aperture. In this way a first-impact loss-map is obtained, identifying locations where high energy deposition are to be expected. This provides a first-level assessment of feasibility and allows to include countermeasures in the conceptual accelerator design.

  15. Temporal profile of betatron radiation from laser-driven electron accelerators

    Czech Academy of Sciences Publication Activity Database

    Horný, Vojtěch; Nejdl, Jaroslav; Kozlová, Michaela; Krůs, Miroslav; Boháček, Karel; Petržílka, Václav; Klimo, Ondřej

    2017-01-01

    Roč. 24, č. 6 (2017), č. článku 063107. ISSN 1070-664X R&D Projects: GA ČR GA15-03118S; GA MŠk LQ1606; GA MŠk(CZ) LM2015083; GA MŠk(CZ) LD14089 EU Projects: European Commission(XE) 654148 - LASERLAB-EUROPE Grant - others:ELI Beamlines(XE) CZ.02.1.01/0.0/0.0/15_008/0000162; GA MŠk(CZ) LM2015042 Institutional support: RVO:61389021 ; RVO:68378271 Keywords : X-ray betatron * laser * X-ray pulses Subject RIV: BL - Plasma and Gas Discharge Physics; BL - Plasma and Gas Discharge Physics (FZU-D) OBOR OECD: Fluids and plasma physics (including surface physics); Fluids and plasma physics (including surface physics) (FZU-D) Impact factor: 2.115, year: 2016 http://aip.scitation.org/doi/full/10.1063/1.4985687

  16. Correction of vertical dispersion and betatron coupling for the CLIC damping ring

    CERN Document Server

    Korostelev, M S

    2006-01-01

    The sensitivity of the CLIC damping ring to various kinds of alignment errors has been studied. Without any correction, fairly small vertical misalignments of the quadrupoles and, in particular, the sextupoles, introduce unacceptable distortions of the closed orbit as well as intolerable spurious vertical dispersion and coupling due to the strong focusing optics of the damping ring. A sophisticated beam-based correction scheme has been developed to bring the design target emittances and the dynamic aperture back to the ideal value. The correction using dipolar correctors and several skew quadrupole correctors allows a minimization of the closed-orbit distortion, the cross-talk between vertical and horizontal closed orbits, the residual vertical dispersion and the betatron coupling.

  17. Neutron doses to personnel from a 24 MeV betatron

    International Nuclear Information System (INIS)

    Beckham, W.A; Entwistle, R.F.

    1987-01-01

    Neutrons are produced by bombardment of most materials by high-energy photons. Because the x-ray shielding around high-energy x-ray generators may not have been designed with neutrons in mind there may be unexpected contributions to the radiation doses of staff working in the immediate vicinity. Neutron fluxes in the working area close to an Allis-Chalmers 24 MeV betatron have been measured using a lithium-6-loaded scintillator and the dose rates calculated. Hazard of staff has been found to be low; typical dose-equivalent rates in occupied areas range from 0.0042 to 0.012 mrem/hour. The flux of fast neutrons in the treatment room was found to be essentially zero. Measurements of neutron flux may be routinely performed using the scintillation detector (NE 912) described, and could usefully form part of the acceptance protocol for any new accelerator

  18. Advanced nonlinear theory: Long-term stability at the SSC

    International Nuclear Information System (INIS)

    Heifets, S.

    1987-01-01

    This paper discussed the long-term stability of the particle beams in the Superconducting Super Collider. In particular the dynamics of a single particle beam is considered in depth. The topics of this paper include: the Hamiltonian of this particle approach, perturbation theory, canonical transformations, interaction of the resonances, structure of the phase space, synchro-Betatron oscillations, modulation diffusion and noise-resonance interaction. 36 refs

  19. A normal form approach to the theory of nonlinear betatronic motion

    International Nuclear Information System (INIS)

    Bazzani, A.; Todesco, E.; Turchetti, G.; Servizi, G.

    1994-01-01

    The betatronic motion of a particle in a circular accelerator is analysed using the transfer map description of the magnetic lattice. In the linear case the transfer matrix approach is shown to be equivalent to the Courant-Snyder theory: In the normal coordinates' representation the transfer matrix is a pure rotation. When the nonlinear effects due to the multipolar components of the magnetic field are taken into account, a similar procedure is used: a nonlinear change of coordinates provides a normal form representation of the map, which exhibits explicit symmetry properties depending on the absence or presence of resonance relations among the linear tunes. The use of normal forms is illustrated in the simplest but significant model of a cell with a sextupolar nonlinearity which is described by the quadratic Henon map. After recalling the basic theoretical results in Hamiltonian dynamics, we show how the normal forms describe the different topological structures of phase space such as KAM tori, chains of islands and chaotic regions; a critical comparison with the usual perturbation theory for Hamilton equations is given. The normal form theory is applied to compute the tune shift and deformation of the orbits for the lattices of the SPS and LHC accelerators, and scaling laws are obtained. Finally, the correction procedure of the multipolar errors of the LHC, based on the analytic minimization of the tune shift computed via the normal forms, is described and the results for a model of the LHC are presented. This application, relevant for the lattice design, focuses on the advantages of normal forms with respect to tracking when parametric dependences have to be explored. (orig.)

  20. Fast betatron tune controller for circulating beam in a synchrotron

    International Nuclear Information System (INIS)

    Endo, Takuyuki; Hatanaka, Kichiji; Sato, Kenji

    1997-01-01

    When rf quadrupole (RFQ) electric field is applied to the circulating beam in a synchrotron, an equation of motion is reduced to Mathieu's Equation. A new analytical method to obtain an approximate solution has been developed, while a numerical computation was usually applied. Translating the behavior of approximate solution into terms of an RFQ electric field and betatron oscillation, a fast tune control can be achieved by rapid tuning of both amplitude and frequency of rf voltage. This process could be applied to suppress a tune shift caused by a space charge effect and to control a slow beam extraction with a low ripple. We have started another analytical computation using Hamiltonian with perturbation of RFQ and the results of this computation also suggest that it is applicable to slow beam extraction. The fast tune controller has been constructed and the beam test will be performed at HIMAC synchrotron in cooperation of RCNP and NIRS. (author)

  1. A method for simultaneous linear optics and coupling correction for storage rings with turn-by-turn beam position monitor data

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Xi [Brookhaven National Laboratory, Upton, Long Island, NY 11973 (United States); Huang, Xiaobiao, E-mail: xiahuang@slac.stanford.edu [SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA 94025 (United States)

    2016-08-21

    We propose a method to simultaneously correct linear optics errors and linear coupling for storage rings using turn-by-turn (TbT) beam position monitor (BPM) data. The independent component analysis (ICA) method is used to isolate the betatron normal modes from the measured TbT BPM data. The betatron amplitudes and phase advances of the projections of the normal modes on the horizontal and vertical planes are then extracted, which, combined with dispersion measurement, are used to fit the lattice model. The fitting results are used for lattice correction. The method has been successfully demonstrated on the NSLS-II storage ring.

  2. A method for simultaneous linear optics and coupling correction for storage rings with turn-by-turn beam position monitor data

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Xi [Brookhaven National Lab. (BNL), Upton, NY (United States); Huang, Xiaobiao [SLAC National Accelerator Lab., Menlo Park, CA (United States)

    2016-08-01

    We propose a method to simultaneously correct linear optics errors and linear coupling for storage rings using turn-by-turn (TbT) beam position monitor (BPM) data. The independent component analysis (ICA) method is used to isolate the betatron normal modes from the measured TbT BPM data. The betatron amplitudes and phase advances of the projections of the normal modes on the horizontal and vertical planes are then extracted, which, combined with dispersion measurement, are used to fit the lattice model. Furthermore, the fitting results are used for lattice correction. Our method has been successfully demonstrated on the NSLS-II storage ring.

  3. Theoretical treatment of transverse feedback systems with memory

    International Nuclear Information System (INIS)

    Cornacchia, M.; Wang, J.M.

    1981-01-01

    The differential equation of the dipole moment of coherent oscillations in the presence of a feedback system is derived. The analysis, which starts in the time domain, is extended to the frequency domain; this allows a straightforward derivation of the damping rate for both coasting and bunched beams. The damping rate is expressed in terms of the transfer function of the feedback system and in a general form which takes into account the β-function and betatron phase modulation along the beam trajectory, the effect of memory arising from the finiteness of the system bandwidth, the effect of the time delay and of the betatron phase advance between detector and kicker. Some examples of the dependence of the damping rate on the feedback parameters are given

  4. Phase mixing of transverse oscillations in the linear and nonlinear regimes for IFR relativistic electron beam propagation

    International Nuclear Information System (INIS)

    Shokair, I.R.

    1991-01-01

    Phase mixing of transverse oscillations changes the nature of the ion hose instability from an absolute to a convective instability. The stronger the phase mixing, the faster an electron beam reaches equilibrium with the guiding ion channel. This is important for long distance propagation of relativistic electron beams where it is desired that transverse oscillations phase mix within a few betatron wavelengths of injection and subsequently an equilibrium is reached with no further beam emittance growth. In the linear regime phase mixing is well understood and results in asymptotic decay of transverse oscillations as 1/Z 2 for a Gaussian beam and channel system, Z being the axial distance measured in betatron wavelengths. In the nonlinear regime (which is likely mode of propagation for long pulse beams) results of the spread mass model indicate that phase mixing is considerably weaker than in the regime. In this paper we consider this problem of phase mixing in the nonlinear regime. Results of the spread mass model will be shown along with a simple analysis of phase mixing for multiple oscillator models. Particle simulations also indicate that phase mixing is weaker in nonlinear regime than in the linear regime. These results will also be shown. 3 refs., 4 figs

  5. Dynamics Assessment of Advanced Single-Phase PLL Structures

    DEFF Research Database (Denmark)

    Golestan, Saeed; Monfarad, Mohammad; Freijedo, Francisco D.

    2013-01-01

    Recently, several advanced phase locked loop (PLL) techniques have been proposed for single-phase applications. Among these, the Park-PLL, and the second order generalized integrator (SOGI) based PLL are very attractive, owing to their simple digital implementation, low computational burden...

  6. Demonstration of no feasibility of a Crystalline Beam in a Betatron Magnet

    Energy Technology Data Exchange (ETDEWEB)

    Ruggiero, A.G.

    1993-09-13

    This technical report investigates the feasibility of a Crystalline Beam in a weak-focussing storage ring like a Betatron. At the same time the curvature effect due to the bending magnet is also investigated. As a special case, the example of a circular one-dimensional string of electrically charged particles is examined. It is found that the motion of the particles is unstable due to the dependence of the precession movement with respect to each other on their radial displacement. That is a form of negative-mass instability which can be avoided with an alternating-focussing structure corresponding to a transition energy above the energy of the particles. The calculation of the particle-particle interaction as well as of the forces due to the external magnetic field is done directly in the laboratory frame. The retarded potential expressions are used at this purpose.

  7. Coherent betatron instability in the Tevatron

    International Nuclear Information System (INIS)

    Bogacz, S.A.; Harrison, M.; Ng, K.Y.

    1988-01-01

    The coherent betatron instability was first observed during the recent 1987-88 Tevatron fixed target run. In this operating mode 1000 consecutive bunches are loaded into the machine at 150 GeV with a bunch spacing of 18.8 /times/ 10 -9 sec (53 MHz). The normalized transverse emittance is typically 15 π /times/ 10 -6 m rad in each plane with a longitudinal emittance of about 1.5 eV-sec. The beam is accelerated to 800 GeV in 13 sec. and then it is resonantly extracted during a 23 sec flat top. As the run progressed the bunch intensities were increased until at about 1.4 /times/ 10 10 ppb (protons per bunch) we experienced the onset of a coherent horizontal oscillation taking place in the later stages of the acceleration cycle (>600 GeV). This rapidly developing coherent instability results in a significant emittance growth, which limits machine performance and in a catastrophic scenario it even prevents extraction of the beam. In this paper we will present a simple analytic description of the observed instability. We will show that a combination of a resistive wall coupled bunch effect and a single bunch slow head-tail instability is consistent with the above observations. Finally, a systematic numerical analysis of our model (growth-time vs chromaticity plots) points to the existence of the ≥1 slow head-tail modes as a plausible mechanism for the observed coherent instability. This last claim, as mentioned before, does not have conclusive experimental evidence, although it is based on a very good agreement between the measured values of the instability growth-time and the ones calculated on the basis of our model. 4 refs., 3 figs

  8. Traveling wave accelerating structures with a large phase advance

    International Nuclear Information System (INIS)

    Paramonov, V.V.

    2012-01-01

    The cells RF parameters for the well known Disk Loaded Waveguide (DLW) are considered in higher pass bands of TM01 wave, providing operating phase advance between 180 o - 1230 o per cell. With an appropriate shape optimization and some additional elements proposed traveling wave structures with such large phase advance overlap the classical first band DLW in RF efficiency. Examples of proposed structures together with RF and dispersion properties are presented.

  9. Two pedigrees of familial advanced sleep phase syndrome in Japan.

    Science.gov (United States)

    Satoh, Kohtoku; Mishima, Kazuo; Inoue, Yuichi; Ebisawa, Takashi; Shimizu, Tetsuo

    2003-06-15

    To determine whether a known missense mutation (bp2106 A/G) in hPer2 (a human homolog of the Drosophila period gene) for familial advanced sleep phase syndrome in a Caucasian family is involved in Japanese familial advanced sleep phase syndrome pedigrees. We identified 2 new Japanese families with advanced sleep phase syndrome, and a systematic survey was carried out in 28 relatives of theses 2 families. A total of 9 affected subjects were identified. The affected members showed significantly strong morningness tendencies compared with the unaffected members in various circadian parameters including the Horne-Ostberg Morningness-Eveningness Questionnaire score (77.3 +/- 4.8 vs 57.5 +/- 7.6, p sleep-onset time (20:45 +/- 75 min vs 23:16 +/- 64 min, p DNA samples were obtained from 7 affected and 7 unaffected subjects. None of the tested subjects possessed the missense mutation (bp2106 A/G) in hPer2. Furthermore, there is no significant linkage between affected subjects with hPer2 region by 2-point mapping and by direct sequencing of 23 exons of hPer2. These findings support the notion of genetic heterogeneity of familial advanced sleep phase syndrome cases in humans. The search for more familial advanced sleep phase syndrome cases and for loci other than hPer2 are necessary to further examine the roles of circadian-related genes in genetically determined human circadian rhythm disorders.

  10. Correction of Magnetic Optics and Beam Trajectory Using LOCO Based Algorithm with Expanded Experimental Data Sets

    Energy Technology Data Exchange (ETDEWEB)

    Romanov, A.; Edstrom, D.; Emanov, F. A.; Koop, I. A.; Perevedentsev, E. A.; Rogovsky, Yu. A.; Shwartz, D. B.; Valishev, A.

    2017-03-28

    Precise beam based measurement and correction of magnetic optics is essential for the successful operation of accelerators. The LOCO algorithm is a proven and reliable tool, which in some situations can be improved by using a broader class of experimental data. The standard data sets for LOCO include the closed orbit responses to dipole corrector variation, dispersion, and betatron tunes. This paper discusses the benefits from augmenting the data with four additional classes of experimental data: the beam shape measured with beam profile monitors; responses of closed orbit bumps to focusing field variations; betatron tune responses to focusing field variations; BPM-to-BPM betatron phase advances and beta functions in BPMs from turn-by-turn coordinates of kicked beam. All of the described features were implemented in the Sixdsimulation software that was used to correct the optics of the VEPP-2000 collider, the VEPP-5 injector booster ring, and the FAST linac.

  11. Positron Source from Betatron X-rays Emitted in a Plasma Wiggler

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, D.K.; Clayton, C.E.; Huang, C.; Joshi, C.; Lu, W.; Marsh, K.A.; Mori, W.B.; Zhou, M.; /UCLA; Barnes, C.D.; Decker, F.J.; Hogan, M.J.; Iverson, R.H.; Krejcik, P.; O' Connell, C.L.; Siemann, R.; Walz, D.R.; /SLAC; Deng, S.; Katsouleas, T.C.; Muggli, P.; Oz, E.; /Southern California U.

    2006-04-21

    In the E-167 plasma wakefield accelerator (PWFA) experiments in the Final Focus Test Beam (FFTB) at the Stanford Linear Accelerator Center (SLAC), an ultra-short, 28.5 GeV electron beam field ionizes a neutral column of Lithium vapor. In the underdense regime, all plasma electrons are expelled creating an ion column. The beam electrons undergo multiple betatron oscillations leading to a large flux of broadband synchrotron radiation. With a plasma density of 3 x 10{sup 17}cm{sup -3}, the effective focusing gradient is near 9 MT/m with critical photon energies exceeding 50 MeV for on-axis radiation. A positron source is the initial application being explored for these X-rays, as photo-production of positrons eliminates many of the thermal stress and shock wave issues associated with traditional Bremsstrahlung sources. Photo-production of positrons has been well-studied; however, the brightness of plasma X-ray sources provides certain advantages. In this paper, we present results of the simulated radiation spectra for the E-167 experiments, and compute the expected positron yield.

  12. Performance of a correlator filter in betatron tune measurements and damping on the NSLS booster

    International Nuclear Information System (INIS)

    Galayda, J.

    1985-01-01

    A ''compensated correlator filter'', described by Kramer, et al. has been used for measurement and damping of betatron oscillations in the NSLS booster. The filter consists of a zero-degree power splitter, a 180-degree splitter, a length of 7/8'' air dielectric coaxial cable, and a short length of RG-58 cable. Connected to a beam position monitor, the output of the filter is proportional to the difference in transverse position of each bunch on subsequent turns. The useful bandwidth of the filter for damping rigid bunch oscillations extends from 10 MHz to 250 MHz, in contrast with the gigahertz bandwidth requirements for stochastic cooling, for which the filter was originally proposed. Attenuation of all rotation harmonics in this bandwidth is 40 to 60 dB

  13. Multiple resonance compensation for betatron coupling and its equivalence with matrix method

    CERN Document Server

    De Ninno, G

    1999-01-01

    Analyses of betatron coupling can be broadly divided into two categories: the matrix approach that decouples the single-turn matrix to reveal the normal modes and the hamiltonian approach that evaluates the coupling in terms of the action of resonances in perturbation theory. The latter is often regarded as being less exact but good for physical insight. The common opinion is that the correction of the two closest sum and difference resonances to the working point is sufficient to reduce the off-axis terms in the 4X4 single-turn matrix, but this is only partially true. The reason for this is explained, and a method is developed that sums to infinity all coupling resonances and, in this way, obtains results equivalent to the matrix approach. The two approaches is discussed with reference to the dynamic aperture. Finally, the extension of the summation method to resonances of all orders is outlined and the relative importance of a single resonance compared to all resonances of a given order is analytically desc...

  14. New microfocus bremsstrahlung source based on betatron B-18 for high-resolution radiography and tomography

    Science.gov (United States)

    Rychkov, M. M.; Kaplin, V. V.; Malikov, E. L.; Smolyanskiy, V. A.; Stepanov, I. B.; Lutsenko, A. S.; Gentsel'man, V.; Vas'kovskiy, I. K.

    2018-01-01

    New microfocus source of hard bremsstrahlung (photon energy > 1 MeV), based on the betatron B-18 with a narrow Ta target inside, for high-resolution radiography and tomography is presented. The first studies of the source demonstrate its possibilities for practical applications to detect the microdefects in products made from heavy materials and to control gaps in joints of parts of composite structures of engineering facilities. The radiography method was used to investigate a compound object consisting of four vertically arranged steel bars between which surfaces were exposed gaps of 10 μm in width. The radiographic image of the object, obtained with a magnification of 2.4, illustrates the good sensitivity of detecting the gaps between adjacent bars, due to the small width of the linear focus of the bremsstrahlung source.

  15. Beam stability in synchrotrons with digital transverse feedback systems in dependence on beam tunes

    International Nuclear Information System (INIS)

    Zhabitskij, V.M.

    2011-01-01

    The beam stability problem in synchrotrons with a digital transverse feedback system (TFS) is studied. The TFS damper kicker (DK) corrects the transverse momentum of a bunch in proportion to its displacement from the closed orbit measured at the location of the beam position monitor (BPM). It is shown that the area and configuration of the beam stability separatrix depend on the beam tune, the feedback gain, the phase balance between the phase advance from BPM to DK and the phase response of the feedback chain at the betatron frequency

  16. The effect of phase advance errors between interaction points on beam halos

    International Nuclear Information System (INIS)

    Chen, T.; Irwin, J.; Siemann, R.H.

    1995-01-01

    Phase advance errors between interaction points (IP) break the symmetry of multi-IP colliders. This symmetry breaking introduces new, lower order resonances which may chance the halo from the beam-beam interaction dramatically. In this paper, the mechanism of introducing new resonances is discussed. Simulation results showing the changes due to phase advance errors are presented. Simulation results are compared with experimental measurements at VEPP-2M

  17. Pump requirements for betatron-generated femtosecond X-ray laser at saturation from inner-shell transitions

    International Nuclear Information System (INIS)

    Ribiere, M.; Grunenwald, J.; Ribeiro, P.; Sebban, S.; Phuoc, K.Ta; Gautier, J.; Kozlova, M.; Zeitoun, P.; Rousse, A.; Jacquemot, S.; Cheron, B.G.

    2012-01-01

    We study pump requirements to produce femtosecond X-ray laser pulses at saturation from inner-shell transitions in the amplified spontaneous emission regime. Since laser-based betatron radiation is considered as the pumping source, we first study the impact of the driving laser power on its intensity. Then we investigate the amplification behavior of the K-a transition of nitrogen at 3.2 nm (395 eV) from radiative transfer calculations coupled with kinetics modeling of the ion population densities. We show that the saturation regime may be experimentally achieved by using PW-class laser-accelerated electron bunches. Finally, we show that this X-ray laser scheme can be extended to heavier atoms and we calculate pump requirements to reach saturation at 1.5 nm (849 eV) from the K-a transition of neon. (authors)

  18. Phase camera experiment for Advanced Virgo

    International Nuclear Information System (INIS)

    Agatsuma, Kazuhiro; Beuzekom, Martin van; Schaaf, Laura van der; Brand, Jo van den

    2016-01-01

    We report on a study of the phase camera, which is a frequency selective wave-front sensor of a laser beam. This sensor is utilized for monitoring sidebands produced by phase modulations in a gravitational wave (GW) detector. Regarding the operation of the GW detectors, the laser modulation/demodulation method is used to measure mirror displacements and used for the position controls. This plays a significant role because the quality of controls affect the noise level of the GW detector. The phase camera is able to monitor each sideband separately, which has a great benefit for the manipulation of the delicate controls. Also, overcoming mirror aberrations will be an essential part of Advanced Virgo (AdV), which is a GW detector close to Pisa. Especially low-frequency sidebands can be affected greatly by aberrations in one of the interferometer cavities. The phase cameras allow tracking such changes because the state of the sidebands gives information on mirror aberrations. A prototype of the phase camera has been developed and is currently tested. The performance checks are almost completed and the installation of the optics at the AdV site has started. After the installation and commissioning, the phase camera will be combined to a thermal compensation system that consists of CO 2 lasers and compensation plates. In this paper, we focus on the prototype and show some limitations from the scanner performance. - Highlights: • The phase camera is being developed for a gravitational wave detector. • A scanner performance limits the operation speed and layout design of the system. • An operation range was found by measuring the frequency response of the scanner.

  19. Phase camera experiment for Advanced Virgo

    Energy Technology Data Exchange (ETDEWEB)

    Agatsuma, Kazuhiro, E-mail: agatsuma@nikhef.nl [National Institute for Subatomic Physics, Amsterdam (Netherlands); Beuzekom, Martin van; Schaaf, Laura van der [National Institute for Subatomic Physics, Amsterdam (Netherlands); Brand, Jo van den [National Institute for Subatomic Physics, Amsterdam (Netherlands); VU University, Amsterdam (Netherlands)

    2016-07-11

    We report on a study of the phase camera, which is a frequency selective wave-front sensor of a laser beam. This sensor is utilized for monitoring sidebands produced by phase modulations in a gravitational wave (GW) detector. Regarding the operation of the GW detectors, the laser modulation/demodulation method is used to measure mirror displacements and used for the position controls. This plays a significant role because the quality of controls affect the noise level of the GW detector. The phase camera is able to monitor each sideband separately, which has a great benefit for the manipulation of the delicate controls. Also, overcoming mirror aberrations will be an essential part of Advanced Virgo (AdV), which is a GW detector close to Pisa. Especially low-frequency sidebands can be affected greatly by aberrations in one of the interferometer cavities. The phase cameras allow tracking such changes because the state of the sidebands gives information on mirror aberrations. A prototype of the phase camera has been developed and is currently tested. The performance checks are almost completed and the installation of the optics at the AdV site has started. After the installation and commissioning, the phase camera will be combined to a thermal compensation system that consists of CO{sub 2} lasers and compensation plates. In this paper, we focus on the prototype and show some limitations from the scanner performance. - Highlights: • The phase camera is being developed for a gravitational wave detector. • A scanner performance limits the operation speed and layout design of the system. • An operation range was found by measuring the frequency response of the scanner.

  20. Beam Manipulation with an RF Dipole

    International Nuclear Information System (INIS)

    Bai, M.

    1999-01-01

    Coherent betatron motion adiabatically excited by an RF dipole has been successfully employed to overcome strong intrinsic spin depolarization resonances in the AGS, while a solenoid partial snake has been used to correct imperfection spin resonances. The experimental results showed that a full spin flip was obtained in passing through an intrinsic spin resonance when all the beam particles were forced to oscillate coherently at a large amplitude without diluting the beam emittance. With this method, they have successfully accelerated polarized beam up to 23.5 GeV/c. A new type of second order spin resonances was also discovered. As a non-destructive manipulation, this method can also be used for nonlinear beam dynamics studies and beam diagnosis such as measuring phase advance and betatron amplitude function

  1. Lifted linear phase filter banks and the polyphase-with-advance representation

    Energy Technology Data Exchange (ETDEWEB)

    Brislawn, C. M. (Christopher M.); Wohlberg, B. E. (Brendt E.)

    2004-01-01

    A matrix theory is developed for the noncausal polyphase-with-advance representation that underlies the theory of lifted perfect reconstruction filter banks and wavelet transforms as developed by Sweldens and Daubechies. This theory provides the fundamental lifting methodology employed in the ISO/IEC JPEG-2000 still image coding standard, which the authors helped to develop. Lifting structures for polyphase-with-advance filter banks are depicted in Figure 1. In the analysis bank of Figure 1(a), the first lifting step updates x{sub 0} with a filtered version of x{sub 1} and the second step updates x{sub 1} with a filtered version of x{sub 0}; gain factors 1/K and K normalize the lowpass- and highpass-filtered output subbands. Each of these steps is inverted by the corresponding operations in the synthesis bank shown in Figure 1(b). Lifting steps correspond to upper- or lower-triangular matrices, S{sub i}(z), in a cascade-form decomposition of the polyphase analysis matrix, H{sub a}(z). Lifting structures can also be implemented reversibly (i.e., losslessly in fixed-precision arithmetic) by rounding the lifting updates to integer values. Our treatment of the polyphase-with-advance representation develops an extensive matrix algebra framework that goes far beyond the results of. Specifically, we focus on analyzing and implementing linear phase two-channel filter banks via linear phase lifting cascade schemes. Whole-sample symmetric (WS) and half-sample symmetric (HS) linear phase filter banks are characterized completely in terms of the polyphase-with-advance representation. The theory benefits significantly from a number of new group-theoretic structures arising in the polyphase-with-advance matrix algebra from the lifting factorization of linear phase filter banks.

  2. Management of Advanced-Phase Chronic Myelogenous Leukemia.

    Science.gov (United States)

    Radich, Jerald P

    2016-05-01

    Chronic myelogenous leukemia represents the poster child of successful precision medicine in cancer, with amazing survival results achieved with targeted tyrosine kinase inhibitors (TKIs) in many patients with chronic-phase disease. Unfortunately, however, this good news has not extended to patients in blast crisis, for whom survival has not clearly been improved with TKIs. During his presentation at the NCCN 21st Annual Conference, Jerald P. Radich, MD, briefly explored the biology behind advanced-stage disease and several of the molecular findings in disease progression. He also reviewed some of the therapeutic options in advanced disease, emphasizing that transplantation, although fraught with some difficulties, offers the best long-term prognosis for patients in blast crisis. Copyright © 2016 by the National Comprehensive Cancer Network.

  3. Simulation of 4-turn algorithms for reconstructing lattice optic functions from orbit measurements

    International Nuclear Information System (INIS)

    Koscielniak, S.; Iliev, A.

    1994-06-01

    We describe algorithms for reconstructing tune, closed-orbit, beta-function and phase advance from four individual turns of beam orbit acquisition data, under the assumption of coherent, almost linear and uncoupled betatron oscillations. To estimate the beta-function at, and phase advance between, position monitors, we require at least one anchor location consisting of two monitors separated by a drift. The algorithms were submitted to a Monte Carlo analysis to find the likely measurement accuracy of the optics functions in the KAON Factory Booster ring racetrack lattice, assuming beam position monitors with surveying and reading errors, and assuming an imperfect lattice with gradient and surveying errors. Some of the results of this study are reported. (author)

  4. The relationship between bioelectrical impedance phase angle and subjective global assessment in advanced colorectal cancer

    Directory of Open Access Journals (Sweden)

    Grutsch James F

    2008-06-01

    Full Text Available Abstract Background Bioelectrical Impedance (BIA derived phase angle is increasingly being used as an objective indicator of nutritional status in advanced cancer. Subjective Global Assessment (SGA is a subjective method of nutritional status. The objective of this study was to investigate the association between BIA derived phase angle and SGA in advanced colorectal cancer. Methods We evaluated a case series of 73 stages III and IV colorectal cancer patients. Patients were classified as either well-nourished or malnourished using the SGA. BIA was conducted on all patients and phase angle was calculated. The correlation between phase angle and SGA was studied using Spearman correlation coefficient. Receiver Operating Characteristic curves were estimated using the non-parametric method to determine the optimal cut-off levels of phase angle. Results Well-nourished patients had a statistically significantly higher (p = 0.005 median phase angle score (6.12 as compared to those who were malnourished (5.18. The Spearman rank correlation coefficient between phase angle and SGA was found to be 0.33 (p = 0.004, suggesting better nutritional status with higher phase angle scores. A phase angle cut-off of 5.2 was 51.7% sensitive and 79.5% specific whereas a cut-off of 6.0 was 82.8% sensitive and 54.5% specific in detecting malnutrition. Interestingly, a phase angle cut-off of 5.9 demonstrated high diagnostic accuracy in males who had failed primary treatment for advanced colorectal cancer. Conclusion Our study suggests that bioimpedance phase angle is a potential nutritional indicator in advanced colorectal cancer. Further research is needed to elucidate the optimal cut-off levels of phase angle that can be incorporated into the oncology clinic for better nutritional evaluation and management.

  5. Federal Radiological Monitoring and Assessment Center advanced part phase response actions

    International Nuclear Information System (INIS)

    Hurley, B.

    1997-01-01

    Federal Radiological Monitoring and Assessment Center (FRMAC) response actions are carried out in Advance Party and Main Party phases of deployment. Response activities are initiated by a FRMAC Home Team prior to and during Advance Party deployment, with Home Team support continuing until the FRMAC Main Party is fully deployed. Upon arrival at the incident scene, the Advance Party establishes communications with other federal, state, and local response organizations, Following an Advance Party Meeting with these response organizations, FRMAC begins formulation of an initial monitoring and sampling plan, in coordination with the jurisdictional state and the Lead Federal Agency, and initiates detailed logistical arrangements for Main Party deployment and operations

  6. UTILITY ADVANCED TURBINE SYSTEMS (ATS) TECHNOLOGY READINESS TESTING: PHASE 3R

    Energy Technology Data Exchange (ETDEWEB)

    None

    1999-09-01

    The overall objective of the Advanced Turbine System (ATS) Phase 3 Cooperative Agreement between GE and the US Department of Energy (DOE) is the development of the GE 7H and 9H combined cycle power systems. The major effort will be expended on detail design. Validation of critical components and technologies will be performed, including: hot gas path component testing, sub-scale compressor testing, steam purity test trials, and rotational heat transfer confirmation testing. Processes will be developed to support the manufacture of the first system, which was to have been sited and operated in Phase 4 but will now be sited and operated commercially by GE. This change has resulted from DOE's request to GE for deletion of Phase 4 in favor of a restructured Phase 3 (as Phase 3R) to include full speed, no load (FSNL) testing of the 7H gas turbine. Technology enhancements that are not required for the first machine design but will be critical for future ATS advances in performance, reliability, and costs will be initiated. Long-term tests of materials to confirm design life predictions will continue. A schematic of the GE H machine is shown. This report summarizes work accomplished in 2Q99.

  7. Relative measurements of fast neutron contamination in 18-MV photon beams from two linear accelerators and a betatron

    International Nuclear Information System (INIS)

    Gur, D.; Bukovitz, A.G.; Rosen, J.C.; Holmes, B.G.

    1979-01-01

    Fast neutron contamination in photon beams in the 20 MV range have been reported in recent years. In order to determine if the variations were due mainly to differences in measurement procedures, or inherent in the design of the accelerators, three different 18-MV (BJR) photon beams were compared using identical analytical techniques. The units studied were a Philips SL/75-20 and a Siemens Mevatron-20 linear accelerators and a Schimadzu betatron. Gamma spectroscopy of an activated aluminum foil was the method used. By comparing the relative amounts of neutron contamination, errors associated with absolute measurements such as detector efficiency and differences in activation foils were eliminated. Fast neutron contaminations per rad of x rays in a ratio of 6.7:3.7:1 were found for the Philips, Schimadzu and Siemens accelerators, respectively

  8. Measurement and stabilization of the longitudinal and transversal tune on the fast energy ramp at ELSA

    Energy Technology Data Exchange (ETDEWEB)

    Eberhardt, Maren [Electron Stretcher Accelerator ELSA, Physikalisches Institut, Universitaet Bonn (Germany)

    2008-07-01

    At the electron stretcher accelerator ELSA, an external beam of unpolarized or polarized electrons is supplied to experimental set-ups. In order to correct for dynamic effects caused by eddy currents induced on the fast energy ramp, the accelerator tunes have to measured in situ with high precision. The measurements of betatron tunes during the fast energy ramp are based on the excitation of coherent betatron oscillations generated by a pulsed kicker magnet. The betatron frequency is determined by a Fourier analysis of the measured oscillations of the beam position. This technique was successfully applied to measure the horizontal tune on the fast energy ramp. During the fast energy ramp shifts of the betatron tune caused by eddy currents are induced. These tune shifts are measured and corrected when operating the accelerator with polarized beam. Measurements of coherent synchrotron oscillations will also be presented. These are excited by a phase modulation of the acceleration voltage using an electrical phase shifter in the reference RF signal path.

  9. Nu shifts in betatron oscillations from uniform perturbations in the presence of non-linear magnetic guide fields

    International Nuclear Information System (INIS)

    Crebbin, K.C.

    1985-05-01

    Uniform magnetic field perturbations cause a closed orbit distortion in a circular accelerator. If the magnetic guide field is non-linear these perturbations can also cause a Nu shift in the betatron oscillations. Such a shift in radial Nu values has been observed in the Bevalac while studying the low energy resonant extraction system. In the Bevalac, the radial perturbation comes from the quadrants being magnetically about 0.8% longer than 90 0 . The normal effect of this type of perturbation is a radial closed orbit shift and orbit distortion. The Nu shift, associated with this type of perturbation in the presence of a non-linear guide field, is discussed in this paper. A method of handling the non-linear n values is discussed as well as the mechanism for the associated Nu shift. Computer calculations are compared to measurements. 2 refs., 4 figs

  10. Confirming the timing of phase-based costing in oncology studies: a case example in advanced melanoma.

    Science.gov (United States)

    Atkins, Michael; Coutinho, Anna D; Nunna, Sasikiran; Gupte-Singh, Komal; Eaddy, Michael

    2018-02-01

    The utilization of healthcare services and costs among patients with cancer is often estimated by the phase of care: initial, interim, or terminal. Although their durations are often set arbitrarily, we sought to establish data-driven phases of care using joinpoint regression in an advanced melanoma population as a case example. A retrospective claims database study was conducted to assess the costs of advanced melanoma from distant metastasis diagnosis to death during January 2010-September 2014. Joinpoint regression analysis was applied to identify the best-fitting points, where statistically significant changes in the trend of average monthly costs occurred. To identify the initial phase, average monthly costs were modeled from metastasis diagnosis to death; and were modeled backward from death to metastasis diagnosis for the terminal phase. Points of monthly cost trend inflection denoted ending and starting points. The months between represented the interim phase. A total of 1,671 patients with advanced melanoma who died met the eligibility criteria. Initial phase was identified as the 5-month period starting with diagnosis of metastasis, after which there was a sharp, significant decline in monthly cost trend (monthly percent change [MPC] = -13.0%; 95% CI = -16.9% to -8.8%). Terminal phase was defined as the 5-month period before death (MPC = -14.0%; 95% CI = -17.6% to -10.2%). The claims-based algorithm may under-estimate patients due to misclassifications, and may over-estimate terminal phase costs because hospital and emergency visits were used as a death proxy. Also, recently approved therapies were not included, which may under-estimate advanced melanoma costs. In this advanced melanoma population, optimal duration of the initial and terminal phases of care was 5 months immediately after diagnosis of metastasis and before death, respectively. Joinpoint regression can be used to provide data-supported phase of cancer care durations, but

  11. Nondestructive Evaluation of Advanced Materials with X-ray Phase Mapping

    Science.gov (United States)

    Hu, Zhengwei

    2005-01-01

    X-ray radiation has been widely used for imaging applications since Rontgen first discovered X-rays over a century ago. Its large penetration depth makes it ideal for the nondestructive visualization of the internal structure and/or defects of materials unobtainable otherwise. Currently used nondestructive evaluation (NDE) tools, X-ray radiography and tomography, are absorption-based, and work well in heavy-element materials where density or composition variations due to internal structure or defects are high enough to produce appreciable absorption contrast. However, in many cases where materials are light-weight and/or composites that have similar mass absorption coefficients, the conventional absorption-based X-ray methods for NDE become less useful. Indeed, the light-weight and ultra-high-strength requirements for the most advanced materials used or developed for current flight mission and future space exploration pose a great challenge to the standard NDE tools in that the absorption contrast arising from the internal structure of these materials is often too weak to be resolved. In this presentation, a solution to the problem, the use of phase information of X-rays for phase contrast X-ray imaging, will be discussed, along with a comparison between the absorption-based and phase-contrast imaging methods. Latest results on phase contrast X-ray imaging of lightweight Space Shuttle foam in 2D and 3D will be presented, demonstrating new opportunities to solve the challenging issues encountered in advanced materials development and processing.

  12. Potential mechanisms of disease progression and management of advanced-phase chronic myeloid leukemia

    Science.gov (United States)

    Jabbour, Elias J.; Hughes, Timothy P.; Cortés, Jorge E.; Kantarjian, Hagop M.; Hochhaus, Andreas

    2014-01-01

    Despite vast improvements in treatment of Philadelphia chromosome–positive chronic myeloid leukemia (CML) in chronic phase (CP), advanced stages of CML, accelerated phase or blast crisis, remain notoriously difficult to treat. Treatments that are highly effective against CML-CP produce disappointing results against advanced disease. Therefore, a primary goal of therapy should be to maintain patients in CP for as long as possible, by (1) striving for deep, early molecular response to treatment; (2) using tyrosine kinase inhibitors that lower risk of disease progression; and (3) more closely observing patients who demonstrate cytogenetic risk factors at diagnosis or during treatment. PMID:24050507

  13. Evaluation of advanced two-phase flow instrumentation in SCTF Core-1

    International Nuclear Information System (INIS)

    Iwamura, Takamichi; Sobajima, Makoto; Osakabe, Masahiro; Ohnuki, Akira; Abe, Yutaka; Sudo, Yukio; Adachi, Hiromichi

    1984-03-01

    In the Slab Core Test Facility (SCTF) Core-I, advanced two-phase flow instruments have been provided by the USNRC to measure the thermohydraulic behavior in the primary system including pressure vessel during the end of blowdown, refill and reflood phases of a postulated loss-of-coolant accident in a pressurized water reactor. The advanced instruments are turbine meters, drag disks, γ-densitometers, spool pieces, liquid level detectors (LLD), fluid distribution grids (FDG), impedance probes (flag, prong and string probes), film probes, and video optical probes. This report presents evaluated results of the data from these instruments. Some instruments are quantitatively evaluated by comparing with the data from the conventional instruments or the other advanced instruments. Main conclusions are as follows: (1) The spool pieces and the γ-densitometers work well and provide satisfactory results; (2) Some of the turbine meters, the impedance probes and the film probes give partially reasonable results, but still more improvements are required; (3) Most of the LLDs, the FDGs, the impedance probes, and the film probes do not work well due to a hard cable corrosion, and (4) The video optical probes give clear image of the flow pattern. (author)

  14. The relationship between bioelectrical impedance phase angle and subjective global assessment in advanced colorectal cancer

    OpenAIRE

    Gupta, Digant; Lis, Christopher G; Dahlk, Sadie L; King, Jessica; Vashi, Pankaj G; Grutsch, James F; Lammersfeld, Carolyn A

    2008-01-01

    Abstract Background Bioelectrical Impedance (BIA) derived phase angle is increasingly being used as an objective indicator of nutritional status in advanced cancer. Subjective Global Assessment (SGA) is a subjective method of nutritional status. The objective of this study was to investigate the association between BIA derived phase angle and SGA in advanced colorectal cancer. Methods We evaluated a case series of 73 stages III and IV colorectal cancer patients. Patients were classified as ei...

  15. A potpourri of impedance measurements at the advanced photon source storage ring

    International Nuclear Information System (INIS)

    Sereno, N.S.; Chae, Y.C.; Harkay, K.C.; Lumpkin, A.H.; Milton, S.V.; Yang, B.X.

    1997-01-01

    Machine coupling impedances were determined in the APS storage ring from measurements of the bunch length, synchronous phase, and synchrotron and betatron tunes vs single-bunch current. The transverse measurements were performed for various numbers of small gap insertion device (ID) chambers installed in the ring. The transverse impedance is determined from measurements of the transverse tunes and bunch length as a function of single-bunch current. The shift in the synchrotron tune was measured as a function of bunch current from which the total cavity impedance was extracted. The loss factor was determined by measuring the relative synchronous phase as a function of bunch current. The longitudinal resistive impedance is calculated using the loss factor dependence on the bunch length. From these results, the authors can estimate what the impedance would be for a full set of ID chambers

  16. The influence of coupled synchrotron-betatron resonances on the extracted beam of the stretcher ring ELSA

    International Nuclear Information System (INIS)

    Neckenig, M.

    1987-09-01

    For the correction of the chromaticity for horizontal and vertical direction each four sextupoles are installed in ELSA. At a working point near 14/3 their influence on the quantity of the stable region of the transverse phase space is essentially smaller than that of the extraction sextupoles. On the other hand the latter lie at positions of low dispersion so that their influence on the chromaticity is negligible; therefore chromaticity correction and choice of the stable phase-space region are not strongly mutually dependent which will be of advance for the later operation. In extraction with corrected chromaticity the electrons are extracted only because of their different position in the transverse phase space which leads to a timely alteration of the η coordinate and by this to a migration of the extracted beam. Consequences of this are the strongly against extraction without chromaticity correction increased emittance and the doubled momentum uncertainty of the beam. Of advance however is the high extraction efficiency of 80% and the small number of the electrons remaining in the ring (below 2%). (orig./HSI) [de

  17. Advanced induction machine model in phase coordinates for wind turbine applications

    DEFF Research Database (Denmark)

    Fajardo, L.A.; Iov, F.; Hansen, Anca Daniela

    2007-01-01

    In this paper an advanced phase coordinates squirrel cage induction machine model with time varying electrical parameters affected by magnetic saturation and rotor deep bar effects, is presented. The model uses standard data sheet for characterization of the electrical parameters, it is developed...

  18. Fundamentals of particle beam dynamics and phase space

    International Nuclear Information System (INIS)

    Weng, W.T.; Mane, S.R.

    1991-01-01

    This report discusses the following topics on synchrotron accelerators: Transverse motion---betatron oscillations; machine lattice; representation of a particle beam; and longitudinal motion---synchrotron oscillations

  19. Prototype system for phase advance measurements of LHC small beam oscillations

    CERN Document Server

    Olexa, J; Brezovic, Z; Gasior, M

    2013-01-01

    Magnet lattice parameters of the Large Hadron Collider (LHC) are measured by exciting beam transverse oscillations that allow measuring their phase advance using the beam position measurement (BPM) system. However, the BPM system requires millimetre oscillation amplitudes, with which nominal high intensity beams would cause large particle loss, dangerous for the LHC superconducting magnets. Therefore, such measurements cannot be done often, as they require special low intensity beams with important set-up time. After its first long shut-down the LHC will be equipped with new collimators with embedded BPMs, for which a new front-end electronics has been developed. Its main processing channels based on compensated diode detectors are designed for beam orbit measurement with sub-micrometre resolution. It is planned to extend this system by adding dedicated channels optimised for phase advance measurement, allowing continuous LHC optics measurement with much smaller beam excitation. This subsystem will be based o...

  20. The correction of linear lattice gradient errors using an AC dipole

    Energy Technology Data Exchange (ETDEWEB)

    Wang,G.; Bai, M.; Litvinenko, V.N.; Satogata, T.

    2009-05-04

    Precise measurement of optics from coherent betatron oscillations driven by ac dipoles have been demonstrated at RHIC and the Tevatron. For RHIC, the observed rms beta-beat is about 10%. Reduction of beta-beating is an essential component of performance optimization at high energy colliders. A scheme of optics correction was developed and tested in the RHIC 2008 run, using ac dipole optics for measurement and a few adjustable trim quadruples for correction. In this scheme, we first calculate the phase response matrix from the. measured phase advance, and then apply singular value decomposition (SVD) algorithm to the phase response matrix to find correction quadruple strengths. We present both simulation and some preliminary experimental results of this correction.

  1. Advanced gastric cancer. The findings of delayed phase dynamic CT and radiologic-histopathologic correlation

    International Nuclear Information System (INIS)

    Monzawa, Shuichi; Omata, Kosaku; Nakazima, Hiroto; Yokosuka, Noriko; Ito, Atuko; Araki, Tsutomu

    2000-01-01

    The aim of this study was to describe delayed phase dynamic CT findings of advanced (T2-T4) gastric cancer and to correlate with histopathologic findings. Quadruple phase dynamic CT including delayed imaging taken five minutes after the start of injection of contrast material was performed in 43 patients with 45 advanced gastric cancer and 20 control subjects with no gastric lesions. On delayed phase CT scans, the attenuation of the gastric wall was equal to or lower than that of the liver parenchyma in the control subjects, therefore, the presence of higher attenuation in the gastric wall was considered to be abnormal and defined as delayed enhancement. Histopathologic findings in the tumors showing delayed enhancement were compared with those in the tumors without this feature. Delayed enhancement was seen in 26 (57%) of the 45 tumors. Eleven of 25 differentiated-type tumors and 15 of 20 undifferentiated-type tumors showed delayed enhancement (p<.05). Delayed enhancement was seen in one of five medullary type tumors, in 11 of 25 intermediate-type tumors, and in 14 of 15 scirrhous-type tumors (p<.005). Delayed enhancement was frequently seen in the tumors with abundant fibrous tissue stroma. Delayed phase dynamic CT may be useful for the characterization of advanced gastric cancer. (author)

  2. Combination of light and melatonin time cues for phase advancing the human circadian clock.

    Science.gov (United States)

    Burke, Tina M; Markwald, Rachel R; Chinoy, Evan D; Snider, Jesse A; Bessman, Sara C; Jung, Christopher M; Wright, Kenneth P

    2013-11-01

    Photic and non-photic stimuli have been shown to shift the phase of the human circadian clock. We examined how photic and non-photic time cues may be combined by the human circadian system by assessing the phase advancing effects of one evening dose of exogenous melatonin, alone and in combination with one session of morning bright light exposure. Randomized placebo-controlled double-blind circadian protocol. The effects of four conditions, dim light (∼1.9 lux, ∼0.6 Watts/m(2))-placebo, dim light-melatonin (5 mg), bright light (∼3000 lux, ∼7 Watts/m(2))-placebo, and bright light-melatonin on circadian phase was assessed by the change in the salivary dim light melatonin onset (DLMO) prior to and following treatment under constant routine conditions. Melatonin or placebo was administered 5.75 h prior to habitual bedtime and 3 h of bright light exposure started 1 h prior to habitual wake time. Sleep and chronobiology laboratory environment free of time cues. Thirty-six healthy participants (18 females) aged 22 ± 4 y (mean ± SD). Morning bright light combined with early evening exogenous melatonin induced a greater phase advance of the DLMO than either treatment alone. Bright light alone and melatonin alone induced similar phase advances. Information from light and melatonin appear to be combined by the human circadian clock. The ability to combine circadian time cues has important implications for understanding fundamental physiological principles of the human circadian timing system. Knowledge of such principles is important for designing effective countermeasures for phase-shifting the human circadian clock to adapt to jet lag, shift work, and for designing effective treatments for circadian sleep-wakefulness disorders.

  3. Combined fluorescence and phase contrast imaging at the Advanced Photon Source

    International Nuclear Information System (INIS)

    Hornberger, B.; Feser, M.; Jacobsen, C.; Vogt, S.; Legnini, D.; Paterson, D.; Rehak, P.; DeGeronimo, G.; Palmer, B.M.; Experimental Facilities Division; State Univ. of New York at Stony Brook Univ.; BNL; Univ. of Vermont

    2006-01-01

    X-ray fluorescence microprobes excel at detecting and quantifying trace metals in biological and environmental science samples, but typically do not detect low Z elements such as carbon and nitrogen. Therefore, it is hard to put the trace metals into context with their natural environment. We are implementing phase contrast capabilities with a segmented detector into several microprobes at the Advanced Photon Source (APS) to address this problem. Qualitative differential phase contrast images from a modified soft x-ray detector already provide very useful information for general users. We are also implementing a quantitative method to recover the absolute phase shift by Fourier filtering detector images. New detectors are under development which are optimized for the signal levels present at the APS. In this paper, we concentrate on fundamental signal to noise considerations comparing absorption and differential phase contrast

  4. Recent advances in synchrotron-based hard x-ray phase contrast imaging

    International Nuclear Information System (INIS)

    Liu, Y; Nelson, J; Andrews, J C; Pianetta, P; Holzner, C

    2013-01-01

    Ever since the first demonstration of phase contrast imaging (PCI) in the 1930s by Frits Zernike, people have realized the significant advantage of phase contrast over conventional absorption-based imaging in terms of sensitivity to ‘transparent’ features within specimens. Thus, x-ray phase contrast imaging (XPCI) holds great potential in studies of soft biological tissues, typically containing low Z elements such as C, H, O and N. Particularly when synchrotron hard x-rays are employed, the favourable brightness, energy tunability, monochromatic characteristics and penetration depth have dramatically enhanced the quality and variety of XPCI methods, which permit detection of the phase shift associated with 3D geometry of relatively large samples in a non-destructive manner. In this paper, we review recent advances in several synchrotron-based hard x-ray XPCI methods. Challenges and key factors in methodological development are discussed, and biological and medical applications are presented. (paper)

  5. Recent advances in synchrotron-based hard x-ray phase contrast imaging

    Science.gov (United States)

    Liu, Y.; Nelson, J.; Holzner, C.; Andrews, J. C.; Pianetta, P.

    2013-12-01

    Ever since the first demonstration of phase contrast imaging (PCI) in the 1930s by Frits Zernike, people have realized the significant advantage of phase contrast over conventional absorption-based imaging in terms of sensitivity to ‘transparent’ features within specimens. Thus, x-ray phase contrast imaging (XPCI) holds great potential in studies of soft biological tissues, typically containing low Z elements such as C, H, O and N. Particularly when synchrotron hard x-rays are employed, the favourable brightness, energy tunability, monochromatic characteristics and penetration depth have dramatically enhanced the quality and variety of XPCI methods, which permit detection of the phase shift associated with 3D geometry of relatively large samples in a non-destructive manner. In this paper, we review recent advances in several synchrotron-based hard x-ray XPCI methods. Challenges and key factors in methodological development are discussed, and biological and medical applications are presented.

  6. Advanced Parkinson's or "complex phase" Parkinson's disease? Re-evaluation is needed.

    Science.gov (United States)

    Titova, Nataliya; Martinez-Martin, Pablo; Katunina, Elena; Chaudhuri, K Ray

    2017-12-01

    Holistic management of Parkinson's disease, now recognised as a combined motor and nonmotor disorder, remains a key unmet need. Such management needs relatively accurate definition of the various stages of Parkinson's from early untreated to late palliative as each stage calls for personalised therapies. Management also needs to have a robust knowledge of the progression pattern and clinical heterogeneity of the presentation of Parkinson's which may manifest in a motor dominant or nonmotor dominant manner. The "advanced" stages of Parkinson's disease qualify for advanced treatments such as with continuous infusion or stereotactic surgery yet the concept of "advanced Parkinson's disease" (APD) remains controversial in spite of growing knowledge of the natural history of the motor syndrome of PD. Advanced PD is currently largely defined on the basis of consensus opinion and thus with several caveats. Nonmotor aspects of PD may also reflect advancing course of the disorder, so far not reflected in usual scale based assessments which are largely focussed on motor symptoms. In this paper, we discuss the problems with current definitions of "advanced" PD and also propose the term "complex phase" Parkinson's disease as an alternative which takes into account a multimodal symptoms and biomarker based approach in addition to patient preference.

  7. A new concept for the control of a slow-extracted beam in a line with rotational optics: Part II

    CERN Document Server

    Benedikt, Michael; Pullia, M

    1999-01-01

    The current trend in hadrontherapy is towards high-precision, conformal scanning of tumours with a 'pencil' beam of light ions or protons, delivered by a synchrotron using slow extraction. The particular shape of the slow-extracted beam segment in phase space and the need to vary the beam size in a lattice with rotating optical elements create a special problem for the design of the extraction transfer line and gantry. The design concept presented in this report is based on telescope modules with integer-pi phase advances in both transverse planes. The beam size in the plane of the extraction is controlled by altering the phase advance and hence the rotation of the extracted beam segment in phase space. The vertical beam size is controlled by stepping the vertical betatron amplitude function over a range of values and passing the changed beam size from 'hand-to-hand' through the telescope modules to the various treatment rooms. In the example given, a combined phase shifter and 'stepper', at a point close to ...

  8. A New Concept for the Control of a Slow-Extracted Beam in a Line with Rotational Optics, 2

    CERN Document Server

    Benedikt, Michael; Pullia, M

    1999-01-01

    The current trend in hadrontherapy is towards high-precision, conformal scanning of tumours with a 'pencil' beam of light ions, or protons, delivered by a synchrotron using slow-extraction. The particular shape of the slow-extracted beam segment in phase space and the need to vary the beam size in a lattice with rotating optical elements create a special problem for the design of the extraction transfer line and gantry. The design concept presented in this report is based on telescope modules with integer-p phase advances in both transverse planes. The beam size in the plane of the extraction is controlled by altering the phase advance and hence the rotation of the extracted beam segment in phase space. The vertical beam size is controlled by stepping the vertical betatron amplitude function over a range of values and passing the changed beam size from 'hand-to-hand' through the telescope modules to the various treatment rooms. In the example given, a combined phase-shifter and 'stepper', at a point close to ...

  9. Josephson phase qubit circuit for the evaluation of advanced tunnel barrier materials

    Energy Technology Data Exchange (ETDEWEB)

    Kline, Jeffrey S; Oh, Seongshik; Pappas, David P [National Institute of Standards and Technology, Boulder, CO 80305 (United States); Wang Haohua; Martinis, John M [Department of Physics, University of California, Santa Barbara, CA 93106 (United States)], E-mail: klinej@nist.gov

    2009-01-15

    We have found that crystalline Josephson junctions have problems with the control of critical current density that decrease the circuit yield. We present a superconducting quantum bit circuit designed to accommodate a factor of five variation in critical current density from one fabrication run to the next. The new design enables the evaluation of advanced tunnel barrier materials for superconducting quantum bits. Using this circuit design, we compare the performance of Josephson phase qubits fabricated with MgO and Al{sub 2}O{sub 3} advanced crystalline tunnel barriers to AlO{sub x} amorphous tunnel barrier qubits.

  10. Advanced Diagnostics of Lattice Parameters in Hadron Colliders

    CERN Document Server

    Koutchouk, Jean-Pierre

    2003-01-01

    With a beam stored energy exceeding by several orders of magnitude the quench level of the magnets and non-negligible non-linear field components, the control of the beam dynamics and losses in LHC must be very precise. This is a strong incentive to strengthen as much as possible the potential of beam diagnostics. This paper reviews some of the developments in various laboratories that appear to have a large potential. They either allow for a much better access to classical beam parameters or for the measurement of quantities formerly not accessible. Examples are a fast measurement of the betatron tunes, the use of PLL for reliable tune tracking and feedback, new methods or ideas to measure the chromaticity with the potential of feedback systems and similarly for the betatron coupling, the measurement of high-order non-linear fields and resonances and the potential of AC dipole excitation. This list is bound to be incomplete as the field is fortunately very dynamic.

  11. A new concept for the control of a slow-extracted beam in a line with rotational optics, 2

    CERN Document Server

    Benedikt, Michael; Pullia, M

    1999-01-01

    For pt.I see ibid., vol.430, p.512-22, 1999. The current trend in hadron therapy is towards high-precision, conformal scanning of tumours with a `pencil' beam of light ions or protons, delivered by a synchrotron using slow extraction. The particular shape of the slow- extracted beam segment in phase space and the need to vary the beam size in a lattice with rotating optical elements create a special problem for the design of the extraction transfer line and gantry. The design concept presented in this report is based on telescope modules with integer- pi phase advances in both transverse planes. The beam size in the plane of the extraction is controlled by altering the phase advance and hence the rotation of the extracted beam segment in phase space. The vertical beam size is controlled by stepping the vertical betatron amplitude function over a range of values and passing the changed beam size from `hand-to-hand' through the telescope modules to the various treatment rooms. In the example given, a combined p...

  12. Measurements of stability limits for a space-charge-dominated ion beam in a long A.G. transport channel

    International Nuclear Information System (INIS)

    Tiefenback, M.G.; Keefe, D.

    1985-05-01

    The Single Beam Transport Experiment at LBL consists of 82 electrostatic quadrupole lenses arranged in a FODO lattice. Five further lenses provide a matched beam from a high-current high-brightness cesium source for injection into the FODO channel. We call the transport conditions stable if both the emittance and current remain unchanged between the beginning and end of the channel, and unstable if either the emittance grows or the current decreases because of collective effects. We have explored the range of single-particle betatron phase advance per period from sigma 0 = 45 0 to 150 0 to determine the stability limits for the space-charge depressed phase advance, sigma. No lower limit for sigma (down to 7 0 ) has been found at sigma 0 = 60 0 , whereas limits have clearly been identified and mapped in the region of sigma 0 above 90 0

  13. Adaptive matching of the iota ring linear optics for space charge compensation

    Energy Technology Data Exchange (ETDEWEB)

    Romanov, A. [Fermilab; Bruhwiler, D. L. [RadiaSoft, Boulder; Cook, N. [RadiaSoft, Boulder; Hall, C. [RadiaSoft, Boulder

    2016-10-09

    Many present and future accelerators must operate with high intensity beams when distortions induced by space charge forces are among major limiting factors. Betatron tune depression of above approximately 0.1 per cell leads to significant distortions of linear optics. Many aspects of machine operation depend on proper relations between lattice functions and phase advances, and can be i proved with proper treatment of space charge effects. We implement an adaptive algorithm for linear lattice re matching with full account of space charge in the linear approximation for the case of Fermilab’s IOTA ring. The method is based on a search for initial second moments that give closed solution and, at the same predefined set of goals for emittances, beta functions, dispersions and phase advances at and between points of interest. Iterative singular value decomposition based technique is used to search for optimum by varying wide array of model parameters

  14. Advanced Dispersed Fringe Sensing Algorithm for Coarse Phasing Segmented Mirror Telescopes

    Science.gov (United States)

    Spechler, Joshua A.; Hoppe, Daniel J.; Sigrist, Norbert; Shi, Fang; Seo, Byoung-Joon; Bikkannavar, Siddarayappa A.

    2013-01-01

    Segment mirror phasing, a critical step of segment mirror alignment, requires the ability to sense and correct the relative pistons between segments from up to a few hundred microns to a fraction of wavelength in order to bring the mirror system to its full diffraction capability. When sampling the aperture of a telescope, using auto-collimating flats (ACFs) is more economical. The performance of a telescope with a segmented primary mirror strongly depends on how well those primary mirror segments can be phased. One such process to phase primary mirror segments in the axial piston direction is dispersed fringe sensing (DFS). DFS technology can be used to co-phase the ACFs. DFS is essentially a signal fitting and processing operation. It is an elegant method of coarse phasing segmented mirrors. DFS performance accuracy is dependent upon careful calibration of the system as well as other factors such as internal optical alignment, system wavefront errors, and detector quality. Novel improvements to the algorithm have led to substantial enhancements in DFS performance. The Advanced Dispersed Fringe Sensing (ADFS) Algorithm is designed to reduce the sensitivity to calibration errors by determining the optimal fringe extraction line. Applying an angular extraction line dithering procedure and combining this dithering process with an error function while minimizing the phase term of the fitted signal, defines in essence the ADFS algorithm.

  15. A Phase I-II dose escalation study of fixed-dose rate gemcitabine, oxaliplatin and capecitabine every two weeks in advanced cholangiocarcinomas

    DEFF Research Database (Denmark)

    Lassen, Ulrik V; Jensen, Lars Henrik; Sorensen, Morten

    2011-01-01

    (O) and capecitabine (C), and evaluate the safety and efficacy of this regimen in patients with advanced cholangiocarcinoma (CC). Methods. In the Phase I part of the study a dose-escalation schedule of FDR G, O and C, administered every two weeks, was performed in patients with solid tumours...... and no other treatments or advanced CC. In the Phase II part response rate, toxicity, progression-free survival (PFS) and overall survival was evaluated in patients with newly diagnosed advanced CC. Results. Thirty-six patients entered the Phase I part and G 1 000 mg/m(2) day 1 and 15, O 60 mg/m(2) day 1...... and 15, and C 1 000 mg/m(2) BID day 1-7 and day 15-21 were established as MTD. In the Phase II part, 41 patients with advanced CC were included. Overall response rate was 34% and 51% had stable disease, resulting in a clinical benefit rate of 85%. Grade III and IV adverse events were rare. Median...

  16. More Options for the NLC Bunch Compressors (LCC-0035)

    International Nuclear Information System (INIS)

    Emma, P.

    2004-01-01

    The present bunch compressor design for the NLC allows control of the final bunch length by way of changes to the horizontal betatron phase advance of the 180 o -turnaround arc. This adjustability requirement significantly constrains the design and cost optimization of the system and excludes the possibility of using permanent magnet quadrupoles in the arc. To relieve this constraint, and to avoid the very strong arc focusing required at the upper limits of the bunch length range, we explore an option of bunch length control using the first compressor stage, with the arc optics fixed

  17. Phase advancing human circadian rhythms with morning bright light, afternoon melatonin, and gradually shifted sleep: can we reduce morning bright-light duration?

    Science.gov (United States)

    Crowley, Stephanie J; Eastman, Charmane I

    2015-02-01

    Efficient treatments to phase-advance human circadian rhythms are needed to attenuate circadian misalignment and the associated negative health outcomes that accompany early-morning shift work, early school start times, jet lag, and delayed sleep phase disorder. This study compared three morning bright-light exposure patterns from a single light box (to mimic home treatment) in combination with afternoon melatonin. Fifty adults (27 males) aged 25.9 ± 5.1 years participated. Sleep/dark was advanced 1 h/day for three treatment days. Participants took 0.5 mg of melatonin 5 h before the baseline bedtime on treatment day 1, and an hour earlier each treatment day. They were exposed to one of three bright-light (~5000 lux) patterns upon waking each morning: four 30-min exposures separated by 30 min of room light (2-h group), four 15-min exposures separated by 45 min of room light (1-h group), and one 30-min exposure (0.5-h group). Dim-light melatonin onsets (DLMOs) before and after treatment determined the phase advance. Compared to the 2-h group (phase shift = 2.4 ± 0.8 h), smaller phase-advance shifts were seen in the 1-h (1.7 ± 0.7 h) and 0.5-h (1.8 ± 0.8 h) groups. The 2-h pattern produced the largest phase advance; however, the single 30-min bright-light exposure was as effective as 1 h of bright light spread over 3.25 h, and it produced 75% of the phase shift observed with 2 h of bright light. A 30-min morning bright-light exposure with afternoon melatonin is an efficient treatment to phase-advance human circadian rhythms. Copyright © 2014 Elsevier B.V. All rights reserved.

  18. Phase advancing human circadian rhythms with morning bright light, afternoon melatonin, and gradually shifted sleep: can we reduce morning bright light duration?

    Science.gov (United States)

    Crowley, Stephanie J.; Eastman, Charmane I.

    2015-01-01

    OBJECTIVE Efficient treatments to phase advance human circadian rhythms are needed to attenuate circadian misalignment and the associated negative health outcomes that accompany early morning shift work, early school start times, jet lag, and delayed sleep phase disorder. This study compared three morning bright light exposure patterns from a single light box (to mimic home treatment) in combination with afternoon melatonin. METHODS Fifty adults (27 males) aged 25.9±5.1 years participated. Sleep/dark was advanced 1 hour/day for 3 treatment days. Participants took 0.5 mg melatonin 5 hours before baseline bedtime on treatment day 1, and an hour earlier each treatment day. They were exposed to one of three bright light (~5000 lux) patterns upon waking each morning: four 30-minute exposures separated by 30 minutes of room light (2 h group); four 15-minute exposures separated by 45 minutes of room light (1 h group), and one 30-minute exposure (0.5 h group). Dim light melatonin onsets (DLMOs) before and after treatment determined the phase advance. RESULTS Compared to the 2 h group (phase shift=2.4±0.8 h), smaller phase advance shifts were seen in the 1 h (1.7±0.7 h) and 0.5 h (1.8±0.8 h) groups. The 2-hour pattern produced the largest phase advance; however, the single 30-minute bright light exposure was as effective as 1 hour of bright light spread over 3.25 h, and produced 75% of the phase shift observed with 2 hours of bright light. CONCLUSIONS A 30-minute morning bright light exposure with afternoon melatonin is an efficient treatment to phase advance human circadian rhythms. PMID:25620199

  19. Phase loop bandwidth measurements on the advanced photon source 352 MHz rf systems

    International Nuclear Information System (INIS)

    Horan, D.; Nassiri, A.; Schwartz, C.

    1997-01-01

    Phase loop bandwidth tests were performed on the Advanced Photon Source storage ring 352-MHz rf systems. These measurements were made using the HP3563A Control Systems Analyzer, with the rf systems running at 30 kilowatts into each of the storage ring cavities, without stored beam. An electronic phase shifter was used to inject approximately 14 degrees of stimulated phase shift into the low-level rf system, which produced measureable response voltage in the feedback loops without upsetting normal rf system operation. With the PID (proportional-integral-differential) amplifier settings at the values used during accelerator operation, the measurement data revealed that the 3-dB response for the cavity sum and klystron power-phase loops is approximately 7 kHz and 45 kHz, respectively, with the cavities the primary bandwidth-limiting factor in the cavity-sum loop. Data were taken at various PID settings until the loops became unstable. Crosstalk between the two phase loops was measured

  20. Dispersion and betatron function correction in the Advanced Photon Source storage ring using singular value decomposition

    International Nuclear Information System (INIS)

    Emery, L.

    1999-01-01

    Magnet errors and off-center orbits through sextuples perturb the dispersion and beta functions in a storage ring (SR), which affects machine performance. In a large ring such as the Advanced Photon Source (APS), the magnet errors are difficult to determine with beam-based methods. Also the non-zero orbit through sextuples result from user requests for steering at light source points. For expediency, a singular value decomposition (SVD) matrix method analogous to orbit correction was adopted to make global corrections to these functions using strengths of several quadrupoles as correcting elements. The direct response matrix is calculated from the model of the perfect lattice. The inverse is calculated by SVD with a selected number of singular vectors. Resulting improvement in the lattice functions and machine performance will be presented

  1. Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma

    NARCIS (Netherlands)

    Ribas, Antoni; Kefford, Richard; Marshall, Margaret A.; Punt, Cornelis J. A.; Haanen, John B.; Marmol, Maribel; Garbe, Claus; Gogas, Helen; Schachter, Jacob; Linette, Gerald; Lorigan, Paul; Kendra, Kari L.; Maio, Michele; Trefzer, Uwe; Smylie, Michael; McArthur, Grant A.; Dreno, Brigitte; Nathan, Paul D.; Mackiewicz, Jacek; Kirkwood, John M.; Gomez-Navarro, Jesus; Huang, Bo; Pavlov, Dmitri; Hauschild, Axel

    2013-01-01

    In phase I/II trials, the cytotoxic T lymphocyte-associated antigen-4-blocking monoclonal antibody tremelimumab induced durable responses in a subset of patients with advanced melanoma. This phase III study evaluated overall survival (OS) and other safety and efficacy end points in patients with

  2. Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma.

    NARCIS (Netherlands)

    Ribas, A.; Kefford, R.; Marshall, Martin; Punt, C.J.A.; Haanen, J.B.; Marmol, M.; Garbe, C.; Gogas, H.; Schachter, J.; Linette, G.; Lorigan, P.; Kendra, K.L.; Maio, M.; Trefzer, U.; Smylie, M.; McArthur, G.A.; Dreno, B.; Nathan, P.D.; Mackiewicz, J.; Kirkwood, J.M.; Gomez-Navarro, J.; Huang, B.; Pavlov, D.; Hauschild, A.

    2013-01-01

    PURPOSE: In phase I/II trials, the cytotoxic T lymphocyte-associated antigen-4-blocking monoclonal antibody tremelimumab induced durable responses in a subset of patients with advanced melanoma. This phase III study evaluated overall survival (OS) and other safety and efficacy end points in patients

  3. Delayed radionecrosis of the cerebral hemispheres following betatron electron beam irradiation for scalp cancer. Pathological and clinical findings in one case

    International Nuclear Information System (INIS)

    Buge, A.; Escourolle, R.; Rancurel, G.; Gray, F.; Pertuiset, B.F.

    1979-01-01

    Three years following an irradiation by the Betatron's electron beam of an epithelioma in left parieto occipital area of the scalp in a female patient aged 77, early suffering from high blood pressure, a fatal pseudo-tumoral brain necrosis occurs presenting as a rapidly increasing from of Wernicke's aphasia. The necropsy shows intense radionecrosis lesions of the brain and the bone, free of any parenchymatous malignant proliferation note-wortly for the striking density of microvascular changes as previously described in radiation therapy. The case observed some years ago, allows to definite again the limits doses of the extracranial irradiations now estimated at 1760 rets. That is the 'Nominal Standard Dose' (NSD) measured by rets and taking into account the number of seances (N) and the duration of irradiation (T) which would be to take the place of 'the total dose' (D) (rads). These dosimetric criteria themselves must be adjusted to the age and the vascular features of each patient [fr

  4. Delayed radionecrosis of the cerebral hemispheres following betatron electron beam irradiation for scalp cancer. Pathological and clinical findings in one case

    Energy Technology Data Exchange (ETDEWEB)

    Buge, A; Escourolle, R; Rancurel, G; Gray, F; Pertuiset, B F [Clinique Neurologique de la Salpetriere, 75 - Paris (France)

    1979-01-01

    Three years following an irradiation by the Betatron's electron beam of an epithelioma in left parieto occipital area of the scalp in a female patient aged 77, early suffering from high blood pressure, a fatal pseudo-tumoral brain necrosis occurs presenting as a rapidly increasing from of Wernicke's aphasia. The necropsy shows intense radionecrosis lesions of the brain and the bone, free of any parenchymatous malignant proliferation note-wortly for the striking density of microvascular changes as previously described in radiation therapy. The case observed some years ago, allows to definite again the limits doses of the extracranial irradiations now estimated at 1760 rets. That is the 'Nominal Standard Dose' (NSD) measured by rets and taking into account the number of seances (N) and the duration of irradiation (T) which would be to take the place of 'the total dose' (D) (rads). These dosimetric criteria themselves must be adjusted to the age and the vascular features of each patient.

  5. Advancement and Application of Multi-Phase CFD Modeling to High Speed Supercavitating Flows

    Science.gov (United States)

    2013-08-13

    October 2008 - December 2013 4. TITLE AND SUBTITLE Advancement and Application of Multi-Phase CFD Modeling to High Speed Supercavitating Flows...influence cavity hysteresis behavior. These observations are used to guide improved supercavitating -vehicle analyses including numerical predictions...experiments, and modeling 15. SUBJECT TERMS supercavitation , computational fluid dynamics, multiphase flow 16. SECURITY CLASSIFICATION OF: a

  6. A dosimetric comparison of two-phase adaptive intensity-modulated radiotherapy for locally advanced nasopharyngeal cancer

    OpenAIRE

    Chitapanarux, Imjai; Chomprasert, Kittisak; Nobnaop, Wannapa; Wanwilairat, Somsak; Tharavichitkul, Ekasit; Jakrabhandu, Somvilai; Onchan, Wimrak; Traisathit, Patrinee; Van Gestel, Dirk

    2015-01-01

    The purpose of this investigation was to evaluate the potential dosimetric benefits of a two-phase adaptive intensity-modulated radiotherapy (IMRT) protocol for patients with locally advanced nasopharyngeal cancer (NPC). A total of 17 patients with locally advanced NPC treated with IMRT had a second computed tomography (CT) scan after 17 fractions in order to apply and continue the treatment with an adapted plan after 20 fractions. To simulate the situation without adaptation, a hybrid plan w...

  7. Testing of the HARpy Application with a View to Replacing SUSSIX in the OMC Software

    CERN Document Server

    Toplis, Matthew Sean

    2017-01-01

    Presented here is an investigation into the suitability of the HARpy application as a replacement for SUSSIX in the Optics Measurement and Corrections (OMC) software. Comparisons have been made between the abilities of SUSSIX and two operating methods of HARpy (BPM and SVD) to identify optics parameters of the LHC — namely amplitude, tune, phase advance and horizontal and vertical coupling of the betatron oscillations of the beam — from real turn-by-turn BPM data. The accuracy and precision of all three methods are compared as a function of number of turns present in the data. A study has also been conducted into the accuracy of both SUSSIX and the HARpy-BPM method when analysing simulated data containing known excitation parameters and several levels of random noise. The HARpy application was found to perform similarly to SUSSIX when analysing real AC Dipole data, showing high accuracy and precision, particularly for the mainline amplitude, tune and phase advance. The analysis of the simulated data did n...

  8. Phase I study of 4-demethoxydaunorubicin by oral route in patients with advanced cancer

    DEFF Research Database (Denmark)

    Krarup-Hansen, A; Andersen, E; Elbaek, K

    1988-01-01

    In a phase I trial 4-demethoxydaunorubicin (4-dm DNR) was administered as oral capsules once a week to 51 adults with advanced mainly gastrointestinal solid tumors. No fatal toxicity was observed at doses up to 25.0 mg/m2. Dose-limiting granulocytopenia and non-hematologic toxicity developed...

  9. Beam-based analysis of day-night performance variations at the SLC linac

    International Nuclear Information System (INIS)

    Decker, F.J.; Akre, R.; Assmann, R.; Bane, K.L.F.; Minty, M.G.; Phinney, N.; Spence, W.L.

    1998-07-01

    Diurnal temperature variations in the linac gallery of the Stanford Linear Collider (SLC) can affect the amplitude and phase of the rf used to accelerate the beam. The SLC employs many techniques for stabilization and compensation of these effects, but residual uncorrected changes still affect the quality of the delivered beam. This paper presents methods developed to monitor and investigate these errors through the beam response. Variations resulting from errors in the rf amplitude or phase can be distinguished by studying six different beam observables: betatron phase advance, oscillation amplitude growth, rms jitter along the linac, measurements of the beam phase with respect to the rf, changes in the required injection phase, and the global energy correction factor. By quantifying the beam response, an uncorrected variation of 14 degree (S-band) during 28 F temperature swings was found in the main rf drive line system between the front and end of the linac

  10. Advanced Situation Awareness Technologies, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Advanced Situation Awareness Technologies (ASAT) will facilitate exploration of the moon surface, and other planetary bodies. ASAT will create an Advanced Situation...

  11. Multiturn extraction and injection by means of adiabatic capture in stable islands of phase space

    Directory of Open Access Journals (Sweden)

    R. Cappi

    2004-02-01

    Full Text Available Recently a novel approach has been proposed for performing multiturn extraction from a circular machine. Such a technique consists of splitting the beam by means of stable islands created in transverse phase space by magnetic elements creating nonlinear fields, such as sextupoles and octupoles. Provided a slow time variation of the linear tune is applied, adiabatic with respect to the betatron motion, the islands can be moved in phase space and eventually charged particles may be trapped inside the stable structures. This generates a certain number of well-separated beamlets. Originally, this principle was successfully tested using a fourth-order resonance. In this paper the approach is generalized by considering other types of resonances as well as the possibility of performing multiple multiturn extractions. The results of numerical simulations are presented and described in detail. Of course, by time reversal, the proposed approach could be used also for multiturn injection.

  12. Beam Diagnosis and Lattice Modeling of the Fermilab Booster

    International Nuclear Information System (INIS)

    Huang, Xiaobiao

    2005-01-01

    A realistic lattice model is a fundamental basis for the operation of a synchrotron. In this study various beam-based measurements, including orbit response matrix (ORM) and BPM turn-by-turn data are used to verify and calibrate the lattice model of the Fermilab Booster. In the ORM study, despite the strong correlation between the gradient parameters of adjacent magnets which prevents a full determination of the model parameters, an equivalent lattice model is obtained by imposing appropriate constraints. The fitted gradient errors of the focusing magnets are within the design tolerance and the results point to the orbit offsets in the sextupole field as the source of gradient errors. A new method, the independent component analysis (ICA) is introduced to analyze multiple BPM turn-by-turn data taken simultaneously around a synchrotron. This method makes use of the redundancy of the data and the time correlation of the source signals to isolate various components, such as betatron motion and synchrotron motion, from raw BPM data. By extracting clean coherent betatron motion from noisy data and separates out the betatron normal modes when there is linear coupling, the ICA method provides a convenient means to measure the beta functions and betatron phase advances. It also separates synchrotron motion from the BPM samples for dispersion function measurement. The ICA method has the capability to separate other perturbation signals and is robust over the contamination of bad BPMs. The application of the ICA method to the Booster has enabled the measurement of the linear lattice functions which are used to verify the existing lattice model. The transverse impedance and chromaticity are measured from turn-by-turn data using high precision tune measurements. Synchrotron motion is also observed in the BPM data. The emittance growth of the Booster is also studied by data taken with ion profile monitor (IPM). Sources of emittance growth are examined and an approach to cure

  13. Advanced high speed X-ray CT scanner for measurement and visualization of multi-phase flow

    International Nuclear Information System (INIS)

    Hori, Keiichi; Fujimoto, Tetsuro; Kawanishi, Kohei; Nishikawa, Hideo

    1998-01-01

    The development of an ultra-fast X-ray computed tomography (CT) scanner has been performed. The object of interest is in a transient or unsettled state, which makes the conventional CT scanner inappropriate. A concept of electrical switching of electron beam of X-ray generation unit is adopted to reduce the scanning time instead of a mechanical motion adopted by a conventional CT scanner. The mechanical motion is a major obstacle to improve the scanning speed. A prototype system with a scanning time of 3.6 milliseconds was developed at first. And, the feasibility was confirmed to measure the dynamic events of two-phase flow. However, faster scanning speed is generally required for the practical use in the thermalhydraulics research field. Therefore, the development of advanced type has been performed. This advanced type can operate under the scanning time of 0.5 milliseconds and is applicable for the measurement of the multi-phase flow with velocity up to 4-5 m/s. (author)

  14. A Fokker-Planck treatment of stochastic particle motion within the framework of a fully coupled 6-dimensional formalism for electron-positron storage rings including classical spin motion in linear approximation

    International Nuclear Information System (INIS)

    Barber, D.P.; Heinemann, K.; Mais, H.; Ripken, G.

    1991-12-01

    In the following report we investigate stochastic particle motion in electron-positron storage ring in the framework of a Fokker-Planck treatment. The motion is described by using the canonical variables χ, p χ , z, p z , σ = s - cxt, p σ = ΔE/E 0 of the fully six-dimensional formalism. Thus synchrotron- and betatron-oscillations are treated simultaneously taking into account all kinds of coupling (synchro-betatron coupling and the coupling of the betatron oscillations by skew quadrupoles and solenoids). In order to set up the Fokker-Planck equation, action-angle variables of the linear coupled motion are introduced. The averaged dimensions of the bunch, resulting from radiation damping of the synchro-betatron oscillations and from an excitation of these oscillations by quantum fluctuations, are calculated by solving the Fokker-Planck equation. The surfaces of constant density in the six-dimensional phase space, given by six-dimensional ellipsoids, are determined. It is shown that the motion of such an ellipsoid under the influence of external fields can be described by six generating orbit vectors which may be combined into a six-dimenional matrix B(s). This 'bunch-shape matrix', B(s), contains complete information about the configuration of the bunch. Classical spin diffusion in linear approximation has also been included so that the dependence of the polarization vector on the orbital phase space coordinates can be studied and another derivation of the linearized depolarization time obtained. (orig.)

  15. High-quality electron beam generation and bright betatron radiation from a cascaded laser wakefield accelerator (Conference Presentation)

    Science.gov (United States)

    Liu, Jiansheng; Wang, Wentao; Li, Wentao; Qi, Rong; Zhang, Zhijun; Yu, Changhai; Wang, Cheng; Liu, Jiaqi; Qing, Zhiyong; Ming, Fang; Xu, Yi; Leng, Yuxin; Li, Ruxin; Xu, Zhizhan

    2017-05-01

    betatron radiation via manipulating the e-beam transverse oscillation in the wakefield. Very brilliant quasi-monochromatic betatron x-rays in tens of keV with significant enhancement both in photon yield and peak energy have been generated. Besides, by employing a self-synchronized all-optical Compton scattering scheme, in which the electron beam collided with the intense driving laser pulse via the reflection of a plasma mirror, we produced tunable quasi-monochromatic MeV γ-rays ( 33% full-width at half-maximum) with a peak brilliance of 3.1×1022 photons s-1 mm-2 mrad-2 0.1% BW at 1 MeV, which is one order of magnitude higher than ever reported value in MeV regime to the best of our knowledge. 1. J. S. Liu, et al., Phys. Rev. Lett. 107, 035001 (2011). 2. X. Wang, et al., Nat. Commun. 4, 1988 (2013). 3. W. P. Leemans, et al., Phys. Rev. Lett. 113, 245002 (2014) 4. W. T. Wang et al., Phys. Rev. Lett. 117, 124801 (2016). 5. Z. J. Zhang et al., Phys. Plasmas 23, 053106 (2016). 6. C. H. Yu et al., Sci. Rep. 6, 29518 (2016).

  16. Dual-polarization interference microscopy for advanced quantification of phase associated with the image field.

    Science.gov (United States)

    Bouchal, Petr; Chmelík, Radim; Bouchal, Zdeněk

    2018-02-01

    A new concept of dual-polarization spatial light interference microscopy (DPSLIM) is proposed and demonstrated experimentally. The method works with two orthogonally polarized modes in which signal and reference waves are combined to realize the polarization-sensitive phase-shifting, thus allowing advanced reconstruction of the phase associated with the image field. The image phase is reconstructed directly from four polarization encoded interference records by a single step processing. This is a progress compared with common methods, in which the phase of the image field is reconstructed using the optical path difference and the amplitudes of interfering waves, which are calculated in multiple-step processing of the records. The DPSLIM is implemented in a common-path configuration using a spatial light modulator, which is connected to a commercial microscope Nikon E200. The optical performance of the method is demonstrated in experiments using both polystyrene microspheres and live LW13K2 cells.

  17. Global Decoupling on the RHIC Ramp

    CERN Document Server

    Luo, Yun; Della Penna, Al; Fischer, Wolfram; Laster, Jonathan S; Marusic, Al; Pilat, Fulvia Caterina; Roser, Thomas; Trbojevic, Dejan

    2005-01-01

    The global betatron decoupling on the ramp is an important issue for the operation of the Relativistic Heavy Ion Collider (RHIC). In the polarized proton run, the betatron tunes are required to keep almost constant on the ramp to avoid spin resonance line crossing and the beam polarization loss. Some possible correction schemes on the ramp, like three-ramp correction, the coupling amplitude modulation and the coupling phase modulaxtion, have been found. The principles of these schemes are shortly reviewed and compared. Operational results of their applications on the RHIC ramps are given.

  18. Collective centroid oscillations as an emittance preservation diagnostic in linear collider linacs

    International Nuclear Information System (INIS)

    Adolphsen, C.E.; Bane, K.L.F.; Spence, W.L.; Woodley, M.D.

    1997-08-01

    Transverse bunch centroid oscillations, induced at operating beam currents at which transverse wakefields are substantial, and observed at Beam Position Monitors, are sensitive to the actual magnetic focusing, energy gain, and rf phase profiles in a linac, and are insensitive to misalignments and jitter sources. In the pulse stealing set-up implemented at the SLC, they thus allow the frequent monitoring of the stability of the in-place emittance growth inhibiting or mitigating measures--primarily the energy scaled magnetic lattice and the rf phases necessary for BNS damping--independent of the actual emittance growth as driven by misalignments and jitter. The authors have developed a physically based analysis technique to meaningfully reduce the data. Oscillation beta-beating is a primary indicator of beam energy errors; shifts in the invariant amplitude reflect differential internal motion along the longitudinally extended bunch and thus are a sensitive indicator of the real rf phases in the machine; shifts in betatron phase advance contain corroborative information sensitive to both effects

  19. Azacytidine in combination with tyrosine kinase inhibitors induced durable responses in patients with advanced phase chronic myelogenous leukemia.

    Science.gov (United States)

    Ruggiu, Mathilde; Oberkampf, Florence; Ghez, David; Cony-Makhoul, Pascale; Beckeriche, Florence; Cano, Isabelle; Taksin, Anne L; Benbrahim, Omar; Ghez, Stéphanie; Farhat, Hassan; Rigaudeau, Sophie; de Gunzburg, Noémie; Lara, Diane; Terre, Christine; Raggueneau, Victoria; Garcia, Isabel; Spentchian, Marc; De Botton, Stéphane; Rousselot, Philippe

    2017-11-28

    Although the tyrosine kinase inhibitor (TKI) era has brought great improvement in outcome in chronic myelogenous leukemia (CML), prognosis of accelerated phase or myeloid blast crisis patients or of de novo Philadelphia chromosome-positive acute myeloid leukemia remains poor. We conducted a retrospective study on patients with advanced phase disease treated with a TKI and azacytidine. Sixteen patients were eligible. Median age was 64.9 years, the median number of previous therapies was 2.5 lines, and median follow-up was 23.1 months. Hematologic response (HR) rate was 81.3%. Median overall survival (OS), event free survival and relapse-free survival (RFS) were 31.5, 23.3, and 32.2 months, respectively. All except one patient were treated as out-patients after the first cycle. Five patients were bridged to allogenic hematopoietic stem cells transplant. The combination of a TKI and azacytidine is a safe and efficient regiment for patients with CML patients in advanced phases.

  20. Subsonic Ultra Green Aircraft Research Phase II: N+4 Advanced Concept Development

    Science.gov (United States)

    Bradley, Marty K.; Droney, Christopher K.

    2012-01-01

    This final report documents the work of the Boeing Subsonic Ultra Green Aircraft Research (SUGAR) team on Task 1 of the Phase II effort. The team consisted of Boeing Research and Technology, Boeing Commercial Airplanes, General Electric, and Georgia Tech. Using a quantitative workshop process, the following technologies, appropriate to aircraft operational in the N+4 2040 timeframe, were identified: Liquefied Natural Gas (LNG), Hydrogen, fuel cell hybrids, battery electric hybrids, Low Energy Nuclear (LENR), boundary layer ingestion propulsion (BLI), unducted fans and advanced propellers, and combinations. Technology development plans were developed.

  1. Irradiation with X-rays phase-advances the molecular clockwork in liver, adrenal gland and pancreas.

    Science.gov (United States)

    Müller, Mareike Hildegard; Rödel, Franz; Rüb, Udo; Korf, Horst-Werner

    2015-02-01

    The circadian clock of man and mammals shows a hierarchic organization. The master clock, located in the suprachiasmatic nuclei (SCN), controls peripheral oscillators distributed throughout the body. Rhythm generation depends on molecular clockworks based on transcriptional/translational interaction of clock genes. Numerous studies have shown that the clockwork in peripheral oscillators is capable to maintain circadian rhythms for several cycles in vitro, i.e. in the absence of signals from the SCN. The aim of the present study is to analyze the effects of irradiation with X-rays on the clockwork of liver, adrenal and pancreas. To this end organotypic slice cultures of liver (OLSC) and organotypic explant cultures of adrenal glands (OAEC) and pancreas (OPEC) were prepared from transgenic mPer2(luc) mice which express luciferase under the control of the promoter of an important clock gene, Per2, and allow to study the dynamics of the molecular clockwork by bioluminometry. The preparations were cultured in a membrane-based liquid-air interface culturing system and irradiated with X-rays at doses of 10 Gy and 50 Gy or left untreated. Bioluminometric real-time recordings show a stable oscillation of all OLSC, OAEC and OPEC for up to 12 days in vitro. Oscillations persist after irradiation with X-rays. However, a dose of 50 Gy caused a phase advance in the rhythm of the OLSC by 5 h, in the OPEC by 7 h and in the OAEC by 6 h. Our study shows that X-rays affect the molecular clockwork in liver, pancreas and adrenal leading to phase advances. Our results confirm and extend previous studies showing a phase-advancing effect of X-rays at the level of the whole animal and single cells.

  2. Thymostimulin in advanced hepatocellular carcinoma: A phase II trial

    Directory of Open Access Journals (Sweden)

    Behl Susanne

    2008-03-01

    Full Text Available Abstract Background Thymostimulin is a thymic peptide fraction with immune-mediated cytotoxicity against hepatocellular carcinoma in vitro. In a phase II trial, we investigated safety and efficacy including selection criteria for best response in advanced or metastasised hepatocellular carcinoma. Methods 44 patients (84 % male, median age 69 years not suitable or refractory to conventional therapy received thymostimulin 75 mg subcutaneously five times per week for a median of 8.2 months until progression or complete response. 3/44 patients were secondarily accessible to local ablation or chemoembolisation. Primary endpoint was overall survival, secondary endpoint tumor response or progression-free survival. A multivariate Cox's regression model was used to identify variables affecting survival. Results Median survival was 11.5 months (95% CI 7.9–15.0 with a 1-, 2- and 3-year survival of 50%, 23% and 9%. In the univariate analysis, a low Child-Pugh-score (p = 0.01, a low score in the Okuda- and CLIP-classification (p Conclusion Outcome in our study rather depended on liver function and intrahepatic tumor growth (presence of liver cirrhosis and Okuda stage in addition to response to thymostimulin, while an invasive HCC phenotype had no influence in the multivariate analysis. Thymostimulin could therefore be considered a safe and promising candidate for palliative treatment in a selected target population with advanced hepatocellular carcinoma, in particular as component of a multimodal therapy concept. Trial registration Current Controlled Trials ISRCTN29319366.

  3. Luminosity lifetime in the Tevatron

    International Nuclear Information System (INIS)

    Jackson, G.; Finley, D.; Johnson, R.P.; Kerns, Q.; McCarthy, J.; Siemann, R.; Zhang, P.

    1988-01-01

    Since the inauguration of colliding proton-antiproton operations in 1987, the Tevatron has exhibited luminosity lifetimes shorter than expected. During a typical colliding beam storage period, called a store, luminosity is calculated periodically by measuring the charge and emittances of each bunch. The growth of the transverse bunch emittances is the dominant cause of luminosity deterioration. Throughout, this period, the position spectrum of the bunches exhibited betatron signals larger than expected from Schottky noise. A model assuming externally driven betatron oscillations explains both the betatron signals and the emittance growth. A program is underway to improve the Tevatron luminosity lifetime. The abort kickers have been identified as sources of emittance growth, and some quadrupole power supplies are further candidates. Because the horizontal dispersion through the RF cavities is nonzero, RF phase noise has been investigated. Noise in the main dipole regulation circuit has also been studied. 13 refs., 4 figs

  4. Advanced Athermal Telescopes, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This proposed innovative athermal telescope design uses advanced lightweight and high-stiffness material of Beryllium-Aluminum (Be-38Al). Peregrine's expertise with...

  5. Advanced Envelope Research for Factory Built Housing, Phase 3 -- Whole-House Prototyping

    Energy Technology Data Exchange (ETDEWEB)

    Levy, E.; Mullens, M.; Rath, P.

    2014-04-01

    The Advanced Envelope Research effort will provide factory homebuilders with high performance, cost-effective envelope designs that can be effectively integrated into the plant production process while meeting the thermal requirements of the 2012 IECC standards. Given the affordable nature of manufactured homes, impact on first cost is a major consideration in developing new envelope technologies. This work is part of a multi-phase effort. Phase 1 identified seven envelope technologies and provided a preliminary assessment of three methods for building high performance walls. Phase 2 focused on developing viable product designs, manufacturing strategies, addressing code and structural issues, and cost analysis of the three selected options. An industry advisory committee helped narrow the research focus to perfecting a stud wall design with exterior continuous insulation (CI). Phase 3, completed in two stages, continued the design development effort, exploring and evaluating a range or methods for applying CI to factory built homes. The scope also included material selection, manufacturing and cost analysis, and prototyping and testing. During this phase, a home was built with CI, evaluated, and placed in service. The experience of building a mock up wall section with CI and then constructing on line a prototype home resolved important concerns about how to integrate the material into the production process. First steps were taken toward finding least expensive approaches for incorporating CI in standard factory building practices and a preliminary assessment suggested that even at this early stage the technology is attractive when viewed from a life cycle cost perspective.

  6. Gas-phase advanced oxidation as an integrated air pollution control technique

    Directory of Open Access Journals (Sweden)

    Getachew A. Adnew

    2016-03-01

    Full Text Available Gas-phase advanced oxidation (GPAO is an emerging air cleaning technology based on the natural self-cleaning processes that occur in the Earth’s atmosphere. The technology uses ozone, UV-C lamps and water vapor to generate gas-phase hydroxyl radicals that initiate oxidation of a wide range of pollutants. In this study four types of GPAO systems are presented: a laboratory scale prototype, a shipping container prototype, a modular prototype, and commercial scale GPAO installations. The GPAO systems treat volatile organic compounds, reduced sulfur compounds, amines, ozone, nitrogen oxides, particles and odor. While the method covers a wide range of pollutants, effective treatment becomes difficult when temperature is outside the range of 0 to 80 °C, for anoxic gas streams and for pollution loads exceeding ca. 1000 ppm. Air residence time in the system and the rate of reaction of a given pollutant with hydroxyl radicals determine the removal efficiency of GPAO. For gas phase compounds and odors including VOCs (e.g. C6H6 and C3H8 and reduced sulfur compounds (e.g. H2S and CH3SH, removal efficiencies exceed 80%. The method is energy efficient relative to many established technologies and is applicable to pollutants emitted from diverse sources including food processing, foundries, water treatment, biofuel generation, and petrochemical industries.

  7. Phase-II study on stereotactic radiotherapy of locally advanced pancreatic carcinoma

    International Nuclear Information System (INIS)

    Hoyer, Morten; Roed, Henrik; Sengelov, Lisa; Traberg, Anders; Ohlhuis, Lars; Pedersen, Jorgen; Nellemann, Hanne; Kiil Berthelsen, Anne; Eberholst, Frey; Engelholm, Svend Aage; Maase, Hans von der

    2005-01-01

    Background and purpose: The majority of patients with pancreatic cancer have advanced disease at the time of diagnosis and are not amenable for surgery. Stereotactic radiotherapy (SRT) may be an alternative treatment for patients with locally advanced disease. The effect of SRT was investigated in the present phase-II trial. Patients and methods: Twenty-two patients with locally advanced and surgically non-resectable, histological proven pancreatic carcinoma were included into the trial. The patients were immobilized by the Elekta stereotactic body frame (SBF) or a custom made body frame. SRT was given on standard LINAC with standard multi-leaf collimator. Central dose was 15 Gyx3 within 5-10 days. Results: Evaluation of response was found to be very difficult due to radiation and tumour related tissue reaction. Only two patients (9%) were found to have a partial response (PR), the remaining had no change (NC) or progression (PD) after treatment. Six patients had local tumour progression, but only one patient had an isolated local failure without simultaneous distant metastasis. Median time to local or distant progression was 4.8 months. Median survival time was 5.7 months and only 5% were alive 1 year after treatment. Acute toxicity reported 14 days after treatment was pronounced. There was a significant deterioration of performance status (P=0.008), more nausea (P=0.001) and more pain (P=0.008) after 14 days compared with base-line. However, 8 of 12 patients (66%) improved in performance status, scored less nausea, pain, or needed less analgesic drugs at 3 months after treatment. Four patients suffered from severe mucositis or ulceration of the stomach or duodenum and one of the patients had a non-fatal ulcer perforation of the stomach. Conclusions: SRT was associated with poor outcome, unacceptable toxicity and questionable palliative effect and cannot be recommended for patients with advanced pancreatic carcinoma

  8. Needs of people with advanced dementia in their final phase of life: A multi-perspective qualitative study in nursing homes.

    Science.gov (United States)

    Schmidt, Holger; Eisenmann, Yvonne; Golla, Heidrun; Voltz, Raymond; Perrar, Klaus Maria

    2018-03-01

    People with advanced dementia present an important target group for palliative care. They suffer a range of symptoms, and their verbal communication abilities are highly restricted. At present, little is known about their needs in the final phase of life. To identify the needs of people with advanced dementia in their final phase of life and to explore the aspects relevant to first recognize and then meet these needs. Multi-perspective qualitative study using grounded theory methodology conducting group discussions, individual interviews, and participant observation. The study encompassed nursing homes and involved health professionals, relatives, and residents with advanced dementia. Data were collected in six nursing homes. Nine group discussions and three individual interviews were conducted comprising 42 health professionals and 14 relatives. Participant observations aided in giving the perspective of 30 residents with advanced dementia. Data analysis generated a total of 25 physical, psychosocial, and spiritual needs divided into 10 categories. Physical needs were classified as follows: "food intake," "physical well-being," and "physical activity and recovery." Categories of psychosocial needs were classified as follows: "adaptation of stimuli," "communication," "personal attention," "participation," "familiarity and safety," as well as "self-determination." Spiritual needs addressed "religion." The results revealed a multitude of key aspects for recognizing and meeting these needs, stressing the importance of personhood. People with advanced dementia in their final phase of life have a multitude of individual and complex needs. This evidence contributes to narrowing the current research gap, offering an orientation framework for research and practice.

  9. Regorafenib for the Treatment of Advanced Gastric Cancer (INTEGRATE): A Multinational Placebo-Controlled Phase II Trial.

    Science.gov (United States)

    Pavlakis, Nick; Sjoquist, Katrin M; Martin, Andrew J; Tsobanis, Eric; Yip, Sonia; Kang, Yoon-Koo; Bang, Yung-Jue; Alcindor, Thierry; O'Callaghan, Christopher J; Burnell, Margot J; Tebbutt, Niall C; Rha, Sun Young; Lee, Jeeyun; Cho, Jae-Yong; Lipton, Lara R; Wong, Mark; Strickland, Andrew; Kim, Jin Won; Zalcberg, John R; Simes, John; Goldstein, David

    2016-08-10

    We evaluated the activity of regorafenib, an oral multikinase inhibitor, in advanced gastric adenocarcinoma. We conducted an international (Australia and New Zealand, South Korea, and Canada) randomized phase II trial in which patients were randomly assigned at a two-to-one ratio and stratified by lines of prior chemotherapy for advanced disease (one v two) and region. Eligible patients received best supportive care plus regorafenib 160 mg or matching placebo orally on days 1 to 21 of each 28-day cycle until disease progression or prohibitive adverse events occurred. The primary end point was progression-free survival (PFS). Final analysis included data to December 31, 2014. A total of 152 patients were randomly assigned from November 7, 2012, to February 25, 2014, yielding 147 evaluable patients (regorafenib, n = 97; placebo, n = 50). Baseline characteristics were balanced. Median PFS significantly differed between groups (regorafenib, 2.6 months; 95% CI, 1.8 to 3.1 and placebo, 0.9 months; 95% CI, 0.9 to 0.9; hazard ratio [HR], 0.40; 95% CI, 0.28 to 0.59; P regorafenib was seen (median, 5.8 months; 95% CI, 4.4 to 6.8 v 4.5 months; 95% CI, 3.4 to 5.2; HR, 0.74; P = .147). Twenty-nine patients assigned to placebo received open-label regorafenib after disease progression. Regorafenib toxicity was similar to that previously reported. In this phase II trial, regorafenib was effective in prolonging PFS in refractory advanced gastric adenocarcinoma. Regional differences were found, but regorafenib was effective in both regional groups. A phase III trial is planned. © 2016 by American Society of Clinical Oncology.

  10. Parkinsonian syndromes presenting with circadian rhythm sleep disorder- advanced sleep-phase type.

    Science.gov (United States)

    Shukla, Garima; Kaul, Bhavna; Gupta, Anupama; Goyal, Vinay; Behari, Madhuri

    2015-01-01

    Circadian rhythm sleep disorder-advanced sleep-phase type is a relatively uncommon disorder, mostly seen among the elderly population. Impaired circadian rhythms have been reported in neurodegenerative conditions; however, there are no reports of any circadian rhythm sleep disorder among patients with Parkinsonian syndromes. We report two patients who presented with this circadian rhythm disorder, and were then diagnosed with a Parkinsonian syndrome. The cases. A 65-year-old retired man presented with history of abrupt change in sleep schedules, sleeping around 6.30-7 p.m. and waking up around 3-4 a.m. for the last 2 months. On detailed examination, the patient was observed to have symmetrical bradykinesia and cogwheel rigidity of limbs. A diagnosis of multiple system atrophy was made, supported by MRI findings and evidence of autonomic dysfunction. Symptoms of change in sleep-wake cycles resolved over the next 1 year, while the patient was treated with dopaminergic therapy. A 47-year-old man, who was being evaluated for presurgical investigation for refractory temporal lobe epilepsy, presented with complaints suggestive of dysarthria, bradykinesia of limbs and frequent falls for 5 months. Simultaneously, he began to sleep around 7 p.m. and wake up at about 2-3 a.m. Examination revealed severe axial rigidity, restricted vertical gaze and bradykinesia of limbs. A diagnosis of progressive supranuclear palsy was made. This is the first report of Parkinson's plus syndromes presenting with a circadian rhythm sleep disorder-advanced sleep-phase type. More prospective assessment for circadian sleep disorders may introduce useful insights into similar associations. Copyright 2015, NMJI.

  11. Advanced supersonic propulsion study, phase 3

    Science.gov (United States)

    Howlett, R. A.; Johnson, J.; Sabatella, J.; Sewall, T.

    1976-01-01

    The variable stream control engine is determined to be the most promising propulsion system concept for advanced supersonic cruise aircraft. This concept uses variable geometry components and a unique throttle schedule for independent control of two flow streams to provide low jet noise at takeoff and high performance at both subsonic and supersonic cruise. The advanced technology offers a 25% improvement in airplane range and an 8 decibel reduction in takeoff noise, relative to first generation supersonic turbojet engines.

  12. Phase I study of afatinib combined with nintedanib in patients with advanced solid tumours.

    Science.gov (United States)

    Bahleda, Rastislav; Hollebecque, Antoine; Varga, Andrea; Gazzah, Anas; Massard, Christophe; Deutsch, Eric; Amellal, Nadia; Farace, Françoise; Ould-Kaci, Mahmoud; Roux, Flavien; Marzin, Kristell; Soria, Jean-Charles

    2015-11-17

    This Phase I study evaluated continuous- and intermittent-dosing (every other week) of afatinib plus nintedanib in patients with advanced solid tumours. In the dose-escalation phase (n=45), maximum tolerated doses (MTDs) were determined for continuous/intermittent afatinib 10, 20, 30 or 40 mg once daily plus continuous nintedanib 150 or 200 mg twice daily. Secondary objectives included safety and efficacy. Clinical activity of continuous afatinib plus nintedanib at the MTD was further evaluated in an expansion phase (n=25). The most frequent dose-limiting toxicities were diarrhoea (11%) and transaminase elevations (7%). Maximum tolerated doses were afatinib 30 mg continuously plus nintedanib 150 mg, and afatinib 40 mg intermittently plus nintedanib 150 mg. Treatment-related adverse events (mostly Grade⩽3) included diarrhoea (98%), asthenia (64%), nausea (62%) and vomiting (60%). In the dose-escalation phase, two patients had partial responses (PRs) and 27 (60%) had stable disease (SD). In the expansion phase, one complete response and three PRs were observed (all non-small cell lung cancer), with SD in 13 (52%) patients. No pharmacokinetic interactions were observed. MTDs of continuous or intermittent afatinib plus nintedanib demonstrated a manageable safety profile with proactive management of diarrhoea. Antitumour activity was observed in patients with solid tumours.

  13. Advances phase-lock techniques

    CERN Document Server

    Crawford, James A

    2008-01-01

    From cellphones to micrprocessors, to GPS navigation, phase-lock techniques are utilized in most all modern electronic devices. This high-level book takes a systems-level perspective, rather than circuit-level, which differentiates it from other books in the field.

  14. Advanced Envelope Research for Factory Built Housing, Phase 3. Whole-House Prototyping

    Energy Technology Data Exchange (ETDEWEB)

    Levy, E. [Advanced Residential Integrated Energy Solutions (ARIES), New York, NY (United States); Mullens, M. [Advanced Residential Integrated Energy Solutions (ARIES), New York, NY (United States); Rath, P. [Advanced Residential Integrated Energy Solutions (ARIES), New York, NY (United States)

    2014-04-01

    The Advanced Envelope Research effort will provide factory homebuilders with high performance, cost-effective envelope designs that can be effectively integrated into the plant production process while meeting the thermal requirements of the 2012 IECC standards. This work is part of a multiphase effort. Phase 1 identified seven envelope technologies and provided a preliminary assessment of three methods for building high performance walls. Phase 2 focused on developing viable product designs, manufacturing strategies, addressing code and structural issues, and cost analysis of the three selected options. An industry advisory committee helped narrow the research focus to perfecting a stud wall design with exterior continuous insulation (CI). This report describes Phase 3, which was completed in two stages and continued the design development effort, exploring and evaluating a range or methods for applying CI to factory built homes. The scope also included material selection, manufacturing and cost analysis, and prototyping and testing. During this phase, a home was built with CI, evaluated, and placed in service. The experience of building a mock up wall section with CI and then constructing on line a prototype home resolved important concerns about how to integrate the material into the production process. First steps were taken toward finding least expensive approaches for incorporating CI in standard factory building practices and a preliminary assessment suggested that even at this early stage the technology is attractive when viewed from a life cycle cost perspective.

  15. Theses. Beam studies for the CERN antiproton decelerator and a new interpretation of the resonance theory for betatron motion

    Energy Technology Data Exchange (ETDEWEB)

    De Ninno, G

    1999-07-01

    The two parts of the thesis are a mission-oriented task devoted to solve some practical problems of the Antiproton Decelerator (AD) project at CERN, and a theoretical study leading to a new method for representing and compensating betatron resonances. The AD is a new machine (at the moment under commissioning at CERN) that will allow the collection and the deceleration of an antiproton beam from 3.5 GeV/c down to 100 MeV/c (the momentum favoured for the foreseen physics experiments). The need to employ the AD magnets over a wide range required a careful study of their characteristics. The presence of a solenoid inside the AD electron cooling device generates linear coupling between the transverse degrees of freedom of the single-particle motion. Coupling can lead to operational problems and therefore a compensation scheme had tobe designed. The long-standing problem has been solved of how to establish a relationship between the two standard methods for dealing with linear coupling: the matrix approach and the Hamiltonian approach. The bridge was built by including in the Hamiltonian approach in the high frequency part of the perturbative Hamiltonian due to coupling. The procedure was generalised to the nonlinear case and, a new method was proposed for dealing both with linear and nonlinear resonances. (author)

  16. Theses. Beam studies for the CERN antiproton decelerator and a new interpretation of the resonance theory for betatron motion

    International Nuclear Information System (INIS)

    De Ninno, G.

    1999-01-01

    The two parts of the thesis are a mission-oriented task devoted to solve some practical problems of the Antiproton Decelerator (AD) project at CERN, and a theoretical study leading to a new method for representing and compensating betatron resonances. The AD is a new machine (at the moment under commissioning at CERN) that will allow the collection and the deceleration of an antiproton beam from 3.5 GeV/c down to 100 MeV/c (the momentum favoured for the foreseen physics experiments). The need to employ the AD magnets over a wide range required a careful study of their characteristics. The presence of a solenoid inside the AD electron cooling device generates linear coupling between the transverse degrees of freedom of the single-particle motion. Coupling can lead to operational problems and therefore a compensation scheme had to be designed. The long-standing problem has been solved of how to establish a relationship between the two standard methods for dealing with linear coupling: the matrix approach and the Hamiltonian approach. The bridge was built by including in the Hamiltonian approach in the high frequency part of the perturbative Hamiltonian due to coupling. The procedure was generalised to the nonlinear case and, a new method was proposed for dealing both with linear and nonlinear resonances. (author)

  17. Advanced conceptual design report. Phase II. Liquid effluent treatment and disposal Project W-252

    International Nuclear Information System (INIS)

    1995-01-01

    This Advanced Conceptual Design Report (ACDR) provides a documented review and analysis of the Conceptual Design Report (CDR), WHC-SD-W252-CDR-001, June 30, 1993. The ACDR provides further design evaluation of the major design approaches and uncertainties identified in the original CDR. The ACDR will provide a firmer basis for the both the design approach and the associated planning for the performance of the Definitive Design phase of the project

  18. Orbit and optics distortion in fixed field alternating gradient muon accelerators

    Directory of Open Access Journals (Sweden)

    Shinji Machida

    2007-11-01

    Full Text Available In a linear nonscaling fixed field alternating gradient (FFAG accelerator, betatron tunes vary over a wide range and a beam has to cross integer and half-integer tunes several times. Although it is plausible to say that integer and half-integer resonances are not harmful if the crossing speed is fast, no quantitative argument exists. With tracking simulation, we studied orbit and optics distortion due to alignment and magnet errors. It was found that the concept of integer and half-integer resonance crossing is irrelevant to explain beam behavior in a nonscaling FFAG when acceleration is fast and betatron tunes change quickly. In a muon FFAG accelerator, it takes 17 turns for acceleration and the betatron tunes change more than 10, for example. Instead, the orbit and optics distortion is excited by random dipole and quadrupole kicks. The latter causes beam size growth because the beam starts tumbling in phase space, but not necessarily with emittance growth.

  19. Advanced fabrication method for the preparation of MOF thin films: Liquid-phase epitaxy approach meets spin coating method.

    KAUST Repository

    Chernikova, Valeriya; Shekhah, Osama; Eddaoudi, Mohamed

    2016-01-01

    Here we report a new and advanced method for the fabrication of highly oriented/polycrystalline metal-organic framework (MOF) thin films. Building on the attractive features of the liquid-phase epitaxy (LPE) approach, a facile spin coating method

  20. Body composition, symptoms, and survival in advanced cancer patients referred to a phase I service.

    Science.gov (United States)

    Parsons, Henrique A; Baracos, Vickie E; Dhillon, Navjot; Hong, David S; Kurzrock, Razelle

    2012-01-01

    Body weight and body composition are relevant to the outcomes of cancer and antineoplastic therapy. However, their role in Phase I clinical trial patients is unknown. We reviewed symptom burden, body composition, and survival in 104 patients with advanced cancer referred to a Phase I oncology service. Symptom burden was analyzed using the MD Anderson Symptom Assessment Inventory(MDASI); body composition was evaluated utilizing computerized tomography(CT) images. A body mass index (BMI)≥25 kg/m² was considered overweight. Sarcopenia, severe muscle depletion, was assessed using CT-based criteria. Most patients were overweight (n = 65, 63%); 53 patients were sarcopenic (51%), including 79% of patients with a BMIbody composition: 215 (71-358) (BMIcancer diagnosis predicted longer survival in multivariate analysis after controlling for age, gender, performance status, and fat index. Patients referred to a Phase I clinic had a high frequency of sarcopenia and a BMI≥25 kg/m², independent of symptom burden. Body composition variables were predictive of clinically relevant survival differences, which is potentially important in developing Phase I studies.

  1. DE-FOA-EE0005502 Advanced Percussive Drilling Technology for Geothermal Exploration and Development Phase II Report.

    Energy Technology Data Exchange (ETDEWEB)

    Su, Jiann-Cherng [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Raymond, David W. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Prasad, Somuri V. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Wolfer, Dale R. [Atlas-Copco Secoroc, LLC, Fagersta (Sweden)

    2017-05-01

    Percussive hammers are a promising advance in drilling technology for geothermal since they rely upon rock reduction mechanisms that are well-suited for use in the hard, brittle rock characteristic of geothermal formations. The project research approach and work plan includes a critical path to development of a high-temperature (HT) percussive hammer using a two- phase approach. The work completed in Phase I of the project demonstrated the viability of percussive hammers and that solutions to technical challenges in design, material technology, and performance are likely to be resolved. Work completed in Phase II focused on testing the findings from Phase I and evaluating performance of the materials and designs at high- operating temperatures. A high-operating temperature (HOT) drilling facility was designed, built, and used to test the performance of the DTH under extreme conditions. Results from the testing indicate that a high-temperature capable hammer can be developed and is a viable alternative for user in the driller's toolbox.

  2. A phase III trial of zoladex and flutamide versus orchiectomy in the treatment of patients with advanced carcinoma of the prostate

    DEFF Research Database (Denmark)

    Iversen, P; Christensen, M G; Friis, E

    1990-01-01

    In a multicenter Phase III trial 264 patients with advanced prostatic cancer were randomized to either bilateral orchiectomy or treatment with zoladex supplemented by flutamide. Presently, median follow-up time is 30 months. A small difference in objective response was recorded in favor of the co......In a multicenter Phase III trial 264 patients with advanced prostatic cancer were randomized to either bilateral orchiectomy or treatment with zoladex supplemented by flutamide. Presently, median follow-up time is 30 months. A small difference in objective response was recorded in favor...... of the combination therapy, whereas no statistically significant difference was found in subjective response to therapy, time to progression, and overall survival. Adverse effects were more commonly encountered in the pharmacologically treated patients. It is concluded that the combination of zoladex plus flutamide...... is not clinically superior to orchiectomy in the treatment of patients with advanced carcinoma of the prostate....

  3. A phase III study of adjuvant chemotherapy in advanced nasopharyngeal carcinoma patients

    International Nuclear Information System (INIS)

    Chi, K.-H.; Chang, Y.-C.; Guo, W.-Y.; Leung, M.-J.; Shiau, C.-Y.; Chen, S.-Y; Wang, L.-W.; Lai, Y.-L.; Hsu, M.-M.; Lian, S.-L.; Chang, C.-H.; Liu, T.-W.; Chin, Y.-H.; Yen, S.-H.; Perng, C.-H.; Chen, Kuang Y.

    2002-01-01

    Purpose: To evaluate the role of adjuvant chemotherapy in locally advanced nasopharyngeal carcinoma (NPC) patients, we conducted a randomized Phase III trial comparing radiotherapy (RT) followed by adjuvant chemotherapy to RT alone in patients with advanced NPC. Methods and Materials: Between November 1994 and March 1999, 157 patients with Stage IV, M 0 (UICC/AJCC, 1992) advanced NPC disease were randomized to receive standard radiotherapy, as follows: 35-40 fractions, 1.8-2.0 Gy/fraction/day, 5 days/week, to a total dose 70-72 Gy with or without 9 weekly cycles of 24-h infusional chemotherapy (20 mg/m 2 cisplatin, 2,200 mg/m 2 5-fluorouracil, and 120 mg/m 2 leucovorin) after RT. Of 157 patients enrolled, 154 (77 radiotherapy, 77 combined therapy) were evaluable for survival and toxicity analysis. Results: With a median follow-up of 49.5 months, the 5-year overall survival and relapse-free survival rates were 60.5% vs. 54.5% (p = 0.5) and 49.5% vs. 54.4% (p = 0.38) for the radiotherapy-alone group and the combined radiotherapy and adjuvant chemotherapy group, respectively. The Cox regression showed that the hazard rates ratio of combined treatment to RT alone was 0.673 (p value = 0.232); the 95% confidence interval was 0.352 and 1.288, respectively. Patients who received combined treatment had a lower systemic relapse rate than radiotherapy-alone patients, according to relapse pattern analysis. The incidence of leukopenia (≥ Grade 3) occurred in 17 out of 819 (2.1%) cycles of weekly chemotherapy. No patient developed moderate to severe mucositis (≥ Grade 3). Conclusions: We conclude that adjuvant chemotherapy after RT for patients with advanced NPC has no benefit for overall survival or relapse-free survival

  4. Treatment of reduced sulphur compounds and SO2 by Gas Phase Advanced Oxidation

    DEFF Research Database (Denmark)

    Meusinger, Carl; Bluhme, Anders Brostrøm; Ingemar, Jonas L.

    2017-01-01

    Reduced sulphur compounds (RSCs) emitted from pig farms are a major problem for agriculture, due to their health and environmental impacts and foul odour. This study investigates the removal of RSCs, including H2S, and their oxidation product SO2 using Gas Phase Advanced Oxidation (GPAO). GPAO...... is a novel air cleaning technique which utilises accelerated atmospheric chemistry to oxidise pollutants before removing their oxidation products as particles. Removal efficiencies of 24.5% and 3.9% were found for 461 ppb of H2S and 714 ppb of SO2 in a laboratory system (volumetric flow Q = 75 m3/h......). A numerical model of the reactor system was developed to explore the basic features of the system; its output was in fair agreement with the experiment. The model verified the role of OH radicals in initiating the oxidation chemistry. All sulphur removed from the gas phase was detected as particulate matter...

  5. Methods of orbit correction system optimization

    International Nuclear Information System (INIS)

    Chao, Yu-Chiu.

    1997-01-01

    Extracting optimal performance out of an orbit correction system is an important component of accelerator design and evaluation. The question of effectiveness vs. economy, however, is not always easily tractable. This is especially true in cases where betatron function magnitude and phase advance do not have smooth or periodic dependencies on the physical distance. In this report a program is presented using linear algebraic techniques to address this problem. A systematic recipe is given, supported with quantitative criteria, for arriving at an orbit correction system design with the optimal balance between performance and economy. The orbit referred to in this context can be generalized to include angle, path length, orbit effects on the optical transfer matrix, and simultaneous effects on multiple pass orbits

  6. Benchmarking of thermalhydraulic loop models for lead-alloy-cooled advanced nuclear energy systems. Phase I: Isothermal forced convection case

    International Nuclear Information System (INIS)

    2012-06-01

    Under the auspices of the NEA Nuclear Science Committee (NSC), the Working Party on Scientific Issues of the Fuel Cycle (WPFC) has been established to co-ordinate scientific activities regarding various existing and advanced nuclear fuel cycles, including advanced reactor systems, associated chemistry and flowsheets, development and performance of fuel and materials and accelerators and spallation targets. The WPFC has different expert groups to cover a wide range of scientific issues in the field of nuclear fuel cycle. The Task Force on Lead-Alloy-Cooled Advanced Nuclear Energy Systems (LACANES) was created in 2006 to study thermal-hydraulic characteristics of heavy liquid metal coolant loop. The objectives of the task force are to (1) validate thermal-hydraulic loop models for application to LACANES design analysis in participating organisations, by benchmarking with a set of well-characterised lead-alloy coolant loop test data, (2) establish guidelines for quantifying thermal-hydraulic modelling parameters related to friction and heat transfer by lead-alloy coolant and (3) identify specific issues, either in modelling and/or in loop testing, which need to be addressed via possible future work. Nine participants from seven different institutes participated in the first phase of the benchmark. This report provides details of the benchmark specifications, method and code characteristics and results of the preliminary study: pressure loss coefficient and Phase-I. A comparison and analysis of the results will be performed together with Phase-II

  7. A dosimetric comparison of two-phase adaptive intensity-modulated radiotherapy for locally advanced nasopharyngeal cancer

    International Nuclear Information System (INIS)

    Chitapanarux, Imjai; Chomprasert, Kittisak; Nobnaop, Wannapa; Wanwilairat, Somsak; Tharavichitkul, Ekasit; Jakrabhandu, Somvilai; Onchan, Wimrak; Patrinee, Traisathit; Gestel, Dirk Van

    2015-01-01

    The purpose of this investigation was to evaluate the potential dosimetric benefits of a two-phase adaptive intensity-modulated radiotherapy (IMRT) protocol for patients with locally advanced nasopharyngeal cancer (NPC). A total of 17 patients with locally advanced NPC treated with IMRT had a second computed tomography (CT) scan after 17 fractions in order to apply and continue the treatment with an adapted plan after 20 fractions. To simulate the situation without adaptation, a hybrid plan was generated by applying the optimization parameters of the original treatment plan to the anatomy of the second CT scan. The dose-volume histograms (DVHs) and dose statistics of the hybrid plan and the adapted plan were compared. The mean volume of the ipsilateral and contralateral parotid gland decreased by 6.1 cm 3 (30.5%) and 5.4 cm 3 (24.3%), respectively. Compared with the hybrid plan, the adapted plan provided a higher dose to the target volumes with better homogeneity, and a lower dose to the organs at risk (OARs). The Dmin of all planning target volumes (PTVs) increased. The Dmax of the spinal cord and brainstem were lower in 94% of the patients (1.6-5.9 Gy, P < 0.001 and 2.1-9.9 Gy, P < 0.001, respectively). The D mean of the contralateral parotid decreased in 70% of the patients (range, 0.2-4.4 Gy). We could not find a relationship between dose variability and weight loss. Our two-phase adaptive IMRT protocol improves dosimetric results in terms of target volumes and OARs in patients with locally advanced NPC. (author)

  8. Advanced Aqueous Phase Catalyst Development using Combinatorial Methods, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Combinatorial methods are proposed to develop advanced Aqueous Oxidation Catalysts (AOCs) with the capability to mineralize organic contaminants present in effluents...

  9. Computed phase equilibria for burnable neutron absorbing materials for advanced pressurized heavy water reactors

    Energy Technology Data Exchange (ETDEWEB)

    Corcoran, E.C. [Department of Chemistry and Chemical Engineering, Royal Military College of Canada, P.O. Box 17000, St. Forces, Kingston, Ont., K7K 7B4 (Canada)], E-mail: emily.corcoran@rmc.ca; Lewis, B.J.; Thompson, W.T. [Department of Chemistry and Chemical Engineering, Royal Military College of Canada, P.O. Box 17000, St. Forces, Kingston, Ont., K7K 7B4 (Canada); Hood, J. [Atomic Energy of Canada Ltd., Sheridan Park, 2251 Speakman Drive, Mississauga, Ont., L5K 1B2 (Canada); Akbari, F.; He, Z. [Atomic Energy of Canada Ltd., Chalk River Laboratories, Chalk River, Ont., K0J 1J0 (Canada); Reid, P. [Atomic Energy of Canada Ltd., Sheridan Park, 2251 Speakman Drive, Mississauga, Ont., L5K 1B2 (Canada)

    2009-03-31

    Burnable neutron absorbing materials are expected to be an integral part of the new fuel design for the Advanced CANDU [CANDU is as a registered trademark of Atomic Energy of Canada Limited.] Reactor. The neutron absorbing material is composed of gadolinia and dysprosia dissolved in an inert cubic-fluorite yttria-stabilized zirconia matrix. A thermodynamic model based on Gibbs energy minimization has been created to provide estimated phase equilibria as a function of composition and temperature. This work includes some supporting experimental studies involving X-ray diffraction.

  10. Gas-phase advanced oxidation for effective, efficient in situ control of pollution

    DEFF Research Database (Denmark)

    Johnson, Matthew Stanley; Nilsson, Elna Johanna Kristina; Svensson, Erik Anders

    2014-01-01

    In this article, gas-phase advanced oxidation, a new method for pollution control building on the photo-oxidation and particle formation chemistry occurring in the atmosphere, is introduced and characterized. The process uses ozone and UV-C light to produce in situ radicals to oxidize pollution......, generating particles that are removed by a filter; ozone is removed using a MnO2 honeycomb catalyst. This combination of in situ processes removes a wide range of pollutants with a comparatively low specific energy input. Two proof-of-concept devices were built to test and optimize the process...... particulate mass. Secondary pollution including formaldehyde and ultrafine particles might be generated, depending on the composition of the primary pollution....

  11. Advanced Carbothermal Electric Reactor, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — ORBITEC proposes to develop the Advanced Carbothermal Electric (ACE) reactor to efficiently extract oxygen from lunar regolith. Unlike state-of-the-art carbothermal...

  12. Advanced Green Micropropulsion System, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Systima in collaboration with University of Washington is developing a high performance injection system for advanced green monopropellant AF-M315E micropropulsion...

  13. Mixed phase clouds: observations and theoretical advances (overview)

    Science.gov (United States)

    Korolev, Alexei

    2013-04-01

    Mixed phase clouds play important role in precipitation formation and radiation budget of the Earth. The microphysical measurements in mixed phase clouds are notoriously difficult due to many technical challenges. The airborne instrumentation for characterization of the microstructure of mixed phase clouds is discussed. The results multiyear airborne observations and measurements of frequency of occurrence of mixed phase, characteristic spatial scales, humidity in mixed phase and ice clouds are presented. A theoretical framework describing the thermodynamics and phase transformation of a three phase component system consisting of ice particles, liquid droplets and water vapor is discussed. It is shown that the Wegener-Bergeron-Findeisen process plays different role in clouds with different dynamics. The problem of maintenance and longevity of mixed phase clouds is discussed.

  14. Advanced Green Micropropulsion System, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Systima in collaboration with the University of Washington will develop a high performance, advanced green monopropellant microthruster (0.1 – 1.0 N) for small- and...

  15. Phase I trial of neoadjuvant concurrent chemoradiotherapy with S-1 and weekly irinotecan in locally advanced rectal cancer

    International Nuclear Information System (INIS)

    Choi, Hye Jin; Kim, Nam-Kyu; Keum, Ki Chang; Cheon, Seong Ha; Shin, Sang Jun; Baik, Seung Hyuk; Choen, Jae Hee; Rha, Sun Young; Roh, Jae Kyung; Jeung, Hei-Cheul; Chung, Hyun Cheol; Ahn, Joong Bae

    2008-01-01

    S-1 is a novel, oral fluoropyrimidine and a known radiosensitizer. We conducted a phase I trial to establish a schedule of S-1/irinotecan with standard pelvic radiotherapy as a preoperative treatment of locally advanced rectal cancer. Our findings suggest that this new combination is feasible and well tolerable

  16. Automated tune measurements in the Advanced Light Source storage ring using a LabVIEW application

    International Nuclear Information System (INIS)

    Hinkson, J.A.; Chin, M.; Kim, C.H.; Nishimura, H.

    1994-06-01

    Horizontal and vertical betatron tunes and the synchrotron tune are measured frequently during storage ring commissioning. The measurements are tedious and subject to human errors. Automating this kind of repetitive measurement is underway using LabVIEW for Windows, a software application supplied by National Instruments Corporation, that provides acquisition, graphing, and analysis of data as well as instrument control through the General Purpose Interface Bus (GPIB). We have added LabVIEW access to the Advanced Light Source (ALS) data base and control system. LabVIEW is a fast and efficient tool for accelerator commissioning and beam physics studies. Hardware used to perform tune measurements include a tracking generator (or a white noise generator), strip line electrodes for external ''citation of the beam, button monitors, and a spectrum analyzer. All three tunes are displayed simultaneously on the spectrum analyzer. Our program automatically identifies three tunes by applying and analyzing small variations and reports the results. This routine can be encapsulated in other applications, for instance, in a chromaticity measurement and correction program

  17. Space charge and beam stability issues of the Fermilab proton driver in Phase I

    Energy Technology Data Exchange (ETDEWEB)

    K. Y. Ng

    2001-08-24

    Issues concerning beam stability of the proposed Fermilab Proton Driver are studied in its Phase I. Although the betatron tune shifts are dominated by space charge, these shifts are less than 0.25 and will therefore not drive the symmetric and antisymmetric modes of the beam envelope into instability. The longitudinal space charge force is large and inductive inserts may be needed to compensate for the distortion of the rf potential. Although the longitudinal impedance is space charge dominated, it will not drive any microwave instability, unless the real part of the impedance coming from the inductive inserts and wall resistivity of the beam tube are large enough. The design of the beam tube is therefore very important in order to limit the flow of eddy current and keep wall resistivity low. The transverse impedance is also space charge dominated. With the Proton Driver operated at an imaginary transition gamma, however, Landau damping will never be canceled and beam stability can be maintained with negative chromaticities.

  18. Imatinib mesylate is effective in children with chronic myelogenous leukemia in late chronic and advanced phase and in relapse after stem cell transplantation

    NARCIS (Netherlands)

    Millot, F; Guilhot, J; Nelken, B; Leblanc, T; De Bont, ES; Bekassy, AN; Gadner, H; Sufliarska, S; Stary, J; Gschaidmeier, H; Guilhot, F; Suttorp, M

    A multicentric phase 2 study was conducted to determine the efficiency and the tolerance of imatinib mesylate in children with chronic myelogenous leukemia (CML) in advanced phase of the disease, in relapse after stem cell transplantation, or in case of failure to an interferon a-based regimen. In

  19. Advanced Envelope Research for Factory Built Housing, Phase 3. Design Development and Prototyping

    Energy Technology Data Exchange (ETDEWEB)

    Levy, E. [ARIES Collaborative, New York, NY (United States); Kessler, B. [ARIES Collaborative, New York, NY (United States); Mullens, M. [ARIES Collaborative, New York, NY (United States); Rath, P. [ARIES Collaborative, New York, NY (United States)

    2014-01-01

    The Advanced Envelope Research effort will provide factory homebuilders with high performance, cost-effective alternative envelope designs. In the near term, these technologies will play a central role in meeting stringent energy code requirements. For manufactured homes, the thermal requirements, last updated by statute in 1994, will move up to the more rigorous IECC 2012 levels in 2013, the requirements of which are consistent with site built and modular housing. This places added urgency on identifying envelope technologies that the industry can implement in the short timeframe. The primary goal of this research is to develop wall designs that meet the thermal requirements based on 2012 IECC standards. Given the affordable nature of manufactured homes, impact on first cost is a major consideration in developing the new envelope technologies. This work is part of a four-phase, multi-year effort. Phase 1 identified seven envelope technologies and provided a preliminary assessment of three selected methods for building high performance wall systems. Phase 2 focused on the development of viable product designs, manufacturing strategies, addressing code and structural issues, and cost analysis of the three selected options. An industry advisory committee helped critique and select the most viable solution to move further in the research -- stud walls with continuous exterior insulation. Phase 3, the subject of the current report, focused on the design development of the selected wall concept and explored variations on the use of exterior foam insulation. The scope also included material selection, manufacturing and cost analysis, and prototyping and testing.

  20. Advanced Envelope Research for Factory Built Housing, Phase 3 -- Design Development and Prototyping

    Energy Technology Data Exchange (ETDEWEB)

    Levy, E. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Kessler, B. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Mullens, M. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Rath, P. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2014-01-01

    The Advanced Envelope Research effort will provide factory homebuilders with high performance, cost-effective alternative envelope designs. In the near term, these technologies will play a central role in meeting stringent energy code requirements. For manufactured homes, the thermal requirements, last updated by statute in 1994, will move up to the more rigorous IECC 2012 levels in 2013, the requirements of which are consistent with site built and modular housing. This places added urgency on identifying envelope technologies that the industry can implement in the short timeframe. The primary goal of this research is to develop wall designs that meet the thermal requirements based on 2012 IECC standards. Given the affordable nature of manufactured homes, impact on first cost is a major consideration in developing the new envelope technologies. This work is part of a four-phase, multi-year effort. Phase 1 identified seven envelope technologies and provided a preliminary assessment of three selected methods for building high performance wall systems. Phase 2 focused on the development of viable product designs, manufacturing strategies, addressing code and structural issues, and cost analysis of the three selected options. An industry advisory committee helped critique and select the most viable solution to move further in the research -- stud walls with continuous exterior insulation. Phase 3, the subject of the current report, focused on the design development of the selected wall concept and explored variations on the use of exterior foam insulation. The scope also included material selection, manufacturing and cost analysis, and prototyping and testing.

  1. A phase I study of imexon plus gemcitabine as first-line therapy for advanced pancreatic cancer.

    Science.gov (United States)

    Cohen, Steven J; Zalupski, Mark M; Modiano, Manuel R; Conkling, Paul; Patt, Yehuda Z; Davis, Peg; Dorr, Robert T; Boytim, Michelle L; Hersh, Evan M

    2010-07-01

    Imexon is an aziridine-derived iminopyrrolidone which has synergy with gemcitabine in pancreatic cancer cell lines. Gemcitabine is a standard therapy for pancreatic cancer. We performed a phase I trial of imexon and gemcitabine to evaluate safety, dose-limiting toxicity (DLT), and maximum tolerated dose (MTD) in patients with advanced pancreatic cancer. Patients with untreated locally advanced or metastatic pancreatic adenocarcinoma received therapy in sequential cohorts on regimen A (n = 19; imexon 200 or 280 mg/m(2) intravenously (IV) over 30 min days 1-5, 15-19 and gemcitabine 800 or 1,000 mg/m(2) IV over 30 min on days 1,8,15 every 28 days) or regimen B (n = 86; imexon 280-1,300 mg/m(2) IV over 30-60 min days 1, 8, and 15 and gemcitabine 1,000 mg/m(2) IV over 30 min on days 1, 8, and 15 every 28 days). One hundred five patients received 340 treatment cycles (median 2, range 1-16). median age 63, 61% male, ECOG PS 0/1 50%/50%, 93% metastatic. DLT was abdominal cramping and pain, often with transient, acute diarrhea. Best response was confirmed partial response (PR) in 11.4%, 8.9% unconfirmed PR, and 48.1% with stable disease. There was a dose proportional increase in imexon AUC across the doses tested with terminal half life 69 min at the MTD and no alteration of gemcitabine pharmacokinetics. The recommended phase II dose of imexon is 875 mg/m(2) with gemcitabine 1,000 mg/m(2). DLT was acute abdominal pain and cramping. Encouraging antitumor responses support further evaluation of this combination in advanced pancreatic cancer.

  2. Phase II study of neoadjuvant gemcitabine, pegylated liposomal doxorubicin, and docetaxel in locally advanced breast cancer.

    Science.gov (United States)

    Artioli, Grazia; Grazia, Artioli; Mocellin, Simone; Simone, Mocellin; Borgato, Lucia; Lucia, Borgato; Cappetta, Alessandro; Alessandro, Cappetta; Bozza, Fernando; Fernando, Bozza; Zavagno, Giorgio; Giorgio, Zavagno; Zovato, Stefania; Stefania, Zovato; Marchet, Alberto; Alberto, Marchet; Pastorelli, Davide; Davide, Pastorelli

    2010-09-01

    This was a phase II study to assess the activity of a novel neoadjuvant regimen in locally-advanced breast cancer. Fifty patients with histological confirmation of locally advanced breast cancer received treatment with gemcitabine 1000 mg/m(2) (day 1) followed by gemcitabine 800 mg/m(2) plus docetaxel 75 mg/m(2) plus pegylated liposomal doxorubicin (PLD) 30 mg/m(2) (day 8) every 3 weeks for at least 4 cycles, plus a final 2 additional cycles. Tumour size was T1 (n=2), T2 (n=32), T3 (n=14), T4 (n=2). All 50 patients underwent surgery. Clinical complete, partial and no response were observed in 13 (26%), 24 (48%) and 11 (22%) patients, respectively (overall response rate: 74%). The number of chemotherapy cycles was found to be an independent predictor of a pathologic complete response. The combination of gemcitabine-docetaxel-PLD can yield high tumour response rates in patients with locally-advanced breast cancer who undergo a full treatment of 6 cycles.

  3. Challenges of in-vacuum and cryogenic permanent magnet undulator technologies

    Directory of Open Access Journals (Sweden)

    Jui-Che Huang

    2017-06-01

    Full Text Available An in-vacuum undulator (IVU provides a means to reach high-brilliance x rays in medium energy storage rings. The development of short period undulators with low phase errors creates the opportunity for an unprecedented brilliant light source in a storage ring. Since the spectral quality from cryogenic permanent magnet undulators (CPMUs has surpassed that of IVUs, NdFeB or PrFeB CPMUs have been proposed for many new advanced storage rings to reach high brilliance x-ray photon beams. In a low emittance ring, not only the performance of the undulator but also the choice of the lattice functions are important design considerations. Optimum betatron functions and a zero-dispersion function shall be provided in the straight sections for IVU/CPMUs. In this paper, relevant factors and design issues for IVUs and CPMUs are discussed together with many technological challenges in short period undulators associated with beam induced–heat load, phase errors, and the deformation of support girders.

  4. Challenges of in-vacuum and cryogenic permanent magnet undulator technologies

    Science.gov (United States)

    Huang, Jui-Che; Kitamura, Hideo; Yang, Chin-Kang; Chang, Cheng-Hsing; Chang, Cheng-Hsiang; Hwang, Ching-Shiang

    2017-06-01

    An in-vacuum undulator (IVU) provides a means to reach high-brilliance x rays in medium energy storage rings. The development of short period undulators with low phase errors creates the opportunity for an unprecedented brilliant light source in a storage ring. Since the spectral quality from cryogenic permanent magnet undulators (CPMUs) has surpassed that of IVUs, NdFeB or PrFeB CPMUs have been proposed for many new advanced storage rings to reach high brilliance x-ray photon beams. In a low emittance ring, not only the performance of the undulator but also the choice of the lattice functions are important design considerations. Optimum betatron functions and a zero-dispersion function shall be provided in the straight sections for IVU/CPMUs. In this paper, relevant factors and design issues for IVUs and CPMUs are discussed together with many technological challenges in short period undulators associated with beam induced-heat load, phase errors, and the deformation of support girders.

  5. Waste incineration models for operation optimization. Phase 1: Advanced measurement equipment for improved operation of waste fired plants; Affaldsforbraendingsmodeller til driftsoptimering. Fase 1: Avanceret maeleudstyr til forbedret drift af affaldsfyrede anlaeg

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-06-01

    This report describes results from the PSO projects ELTRA-5294 and ELTRA-5348: Waste incineration models for operation optimization. Phase 1, and Advanced measurement equipment for improved operation of waste fired plants. Phase 1. The two projects form the first step in a project course build on a long-term vision of a fully automatic system using a wide range of advanced measurement data, advanced dynamic models for prediction of operation and advanced regulation methods for optimization of the operation of waste incinerator plants. (BA)

  6. Everolimus for Previously Treated Advanced Gastric Cancer: Results of the Randomized, Double-Blind, Phase III GRANITE-1 Study

    Science.gov (United States)

    Ohtsu, Atsushi; Ajani, Jaffer A.; Bai, Yu-Xian; Bang, Yung-Jue; Chung, Hyun-Cheol; Pan, Hong-Ming; Sahmoud, Tarek; Shen, Lin; Yeh, Kun-Huei; Chin, Keisho; Muro, Kei; Kim, Yeul Hong; Ferry, David; Tebbutt, Niall C.; Al-Batran, Salah-Eddin; Smith, Heind; Costantini, Chiara; Rizvi, Syed; Lebwohl, David; Van Cutsem, Eric

    2013-01-01

    Purpose The oral mammalian target of rapamycin inhibitor everolimus demonstrated promising efficacy in a phase II study of pretreated advanced gastric cancer. This international, double-blind, phase III study compared everolimus efficacy and safety with that of best supportive care (BSC) in previously treated advanced gastric cancer. Patients and Methods Patients with advanced gastric cancer that progressed after one or two lines of systemic chemotherapy were randomly assigned to everolimus 10 mg/d (assignment schedule: 2:1) or matching placebo, both given with BSC. Randomization was stratified by previous chemotherapy lines (one v two) and region (Asia v rest of the world [ROW]). Treatment continued until disease progression or intolerable toxicity. Primary end point was overall survival (OS). Secondary end points included progression-free survival (PFS), overall response rate, and safety. Results Six hundred fifty-six patients (median age, 62.0 years; 73.6% male) were enrolled. Median OS was 5.4 months with everolimus and 4.3 months with placebo (hazard ratio, 0.90; 95% CI, 0.75 to 1.08; P = .124). Median PFS was 1.7 months and 1.4 months in the everolimus and placebo arms, respectively (hazard ratio, 0.66; 95% CI, 0.56 to 0.78). Common grade 3/4 adverse events included anemia, decreased appetite, and fatigue. The safety profile was similar in patients enrolled in Asia versus ROW. Conclusion Compared with BSC, everolimus did not significantly improve overall survival for advanced gastric cancer that progressed after one or two lines of previous systemic chemotherapy. The safety profile observed for everolimus was consistent with that observed for everolimus in other cancers. PMID:24043745

  7. Characterization and Suppression of the Electromagnetic Interference Induced Phase Shift in the JLab FEL Photo - Injector Advanced Drive Laser System

    Energy Technology Data Exchange (ETDEWEB)

    F. G. Wilson, D. Sexton, S. Zhang

    2011-09-01

    The drive laser for the photo-cathode gun used in the JLab Free Electron Laser (FEL) facility had been experiencing various phase shifts on the order of tens of degrees (>20{sup o} at 1497 MHz or >40ps) when changing the Advanced Drive Laser (ADL) [2][3][4] micro-pulse frequencies. These phase shifts introduced multiple complications when trying to setup the accelerator for operation, ultimately inhibiting the robustness and overall performance of the FEL. Through rigorous phase measurements and systematic characterizations, we determined that the phase shifts could be attributed to electromagnetic interference (EMI) coupling into the ADL phase control loop, and subsequently resolved the issue of phase shift to within tenths of a degree (<0.5{sup o} at 1497 MHz or <1ps). The diagnostic method developed and the knowledge gained through the entire process will prove to be invaluable for future designs of similar systems.

  8. Advancing Physics evaluated

    Science.gov (United States)

    Ogborn, Jon

    2003-07-01

    The first phase of an evaluation of the new AS/A-level course Advancing Physics, sponsored by the Institute of Physics, is now complete. It shows that the course has achieved very high satisfaction ratings from teachers of the course, and that a majority of these teachers see it as achieving its main aims. The first phase of the evaluation was designed to pinpoint aspects of Advancing Physics that offer scope for improvement. Two such aspects have been identified: course planning and use of the CD-ROM material, and arrangements for coursework in the examination.

  9. Phase I expansion and pharmacodynamic study of the oral MEK inhibitor RO4987655 (CH4987655) in selected patients with advanced cancer with RAS-RAF mutations

    NARCIS (Netherlands)

    Zimmer, Lisa; Barlesi, Fabrice; Martinez-Garcia, Maria; Dieras, Veronique; Schellens, Jan H M; Spano, Jean-Philippe; Middleton, Mark R; Calvo, Emiliano; Paz-Ares, Luiz; Larkin, James; Pacey, Simon; Venturi, Miro; Kraeber-Bodéré, Françoise; Tessier, Jean J L; Eberhardt, Wilfried Ernst Erich; Paques, Michel; Guarin, Ernesto; Meresse, Valerie; Soria, Jean-Charles

    2014-01-01

    PURPOSE: This phase I expansion study assessed safety, pharmacodynamic effects, and antitumor activity of RO4987655, a pure MEK inhibitor, in selected patients with advanced solid tumor. EXPERIMENTAL DESIGN: We undertook a multicenter phase I two-part study (dose escalation and cohort expansion).

  10. Pooled analysis of phase II trials evaluating weekly or conventional cisplatin as first-line therapy for advanced urothelial carcinoma

    DEFF Research Database (Denmark)

    Maughan, Benjamin L; Agarwal, Neeraj; Hussain, Syed A

    2013-01-01

    Weekly gemcitabine with GC every 3-4 weeks is considered conventional first-line chemotherapy for advanced urothelial carcinoma (UC). Weekly split-dose cisplatin with wGC might be less toxic and have similar activity, but has not been compared with GC. We pooled published phase II trials of GC an...

  11. Advanced Si solid phase crystallization for vertical channel in vertical NANDs

    Directory of Open Access Journals (Sweden)

    Sangsoo Lee

    2014-07-01

    Full Text Available The advanced solid phase crystallization (SPC method using the SiGe/Si bi-layer structure is proposed to obtain high-mobility poly-Si thin-film transistors in next generation vertical NAND (VNAND devices. During the SPC process, the top SiGe thin film acts as a selective nucleation layer to induce surface nucleation and equiaxial microstructure. Subsequently, this SiGe thin film microstructure is propagated to the underlying Si thin film by epitaxy-like growth. The initial nucleation at the SiGe surface was clearly observed by in situ transmission electron microscopy (TEM when heating up to 600 °C. The equiaxial microstructures of both SiGe nucleation and Si channel layers were shown in the crystallized bi-layer plan-view TEM measurements. Based on these experimental results, the large-grained and less-defective Si microstructure is expected to form near the channel region of each VNAND cell transistor, which may improve the electrical characteristics.

  12. Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind phase III trial.

    Science.gov (United States)

    Wells, Samuel A; Robinson, Bruce G; Gagel, Robert F; Dralle, Henning; Fagin, James A; Santoro, Massimo; Baudin, Eric; Elisei, Rossella; Jarzab, Barbara; Vasselli, James R; Read, Jessica; Langmuir, Peter; Ryan, Anderson J; Schlumberger, Martin J

    2012-01-10

    There is no effective therapy for patients with advanced medullary thyroid carcinoma (MTC). Vandetanib, a once-daily oral inhibitor of RET kinase, vascular endothelial growth factor receptor, and epidermal growth factor receptor signaling, has previously shown antitumor activity in a phase II study of patients with advanced hereditary MTC. Patients with advanced MTC were randomly assigned in a 2:1 ratio to receive vandetanib 300 mg/d or placebo. On objective disease progression, patients could elect to receive open-label vandetanib. The primary end point was progression-free survival (PFS), determined by independent central Response Evaluation Criteria in Solid Tumors (RECIST) assessments. Between December 2006 and November 2007, 331 patients (mean age, 52 years; 90% sporadic; 95% metastatic) were randomly assigned to receive vandetanib (231) or placebo (100). At data cutoff (July 2009; median follow-up, 24 months), 37% of patients had progressed and 15% had died. The study met its primary objective of PFS prolongation with vandetanib versus placebo (hazard ratio [HR], 0.46; 95% CI, 0.31 to 0.69; P < .001). Statistically significant advantages for vandetanib were also seen for objective response rate (P < .001), disease control rate (P = .001), and biochemical response (P < .001). Overall survival data were immature at data cutoff (HR, 0.89; 95% CI, 0.48 to 1.65). A final survival analysis will take place when 50% of the patients have died. Common adverse events (any grade) occurred more frequently with vandetanib compared with placebo, including diarrhea (56% v 26%), rash (45% v 11%), nausea (33% v 16%), hypertension (32% v 5%), and headache (26% v 9%). Vandetanib demonstrated therapeutic efficacy in a phase III trial of patients with advanced MTC (ClinicalTrials.gov NCT00410761).

  13. Heterogeneous FDG-guided dose-escalation for locally advanced NSCLC (the NARLAL2 trial): Design and early dosimetric results of a randomized, multi-centre phase-III study

    DEFF Research Database (Denmark)

    Møller, Ditte Sloth; Nielsen, Tine Bjørn; Brink, Carsten

    2017-01-01

    Background and purpose: Local recurrence is frequent in locally advanced NSCLC and is primarily located in FDG-avid parts of tumour and lymph nodes. Aiming at improving local control without increasing toxicity, we designed a multi-centre phase-III trial delivering inhomogeneous dose-escalation d......Background and purpose: Local recurrence is frequent in locally advanced NSCLC and is primarily located in FDG-avid parts of tumour and lymph nodes. Aiming at improving local control without increasing toxicity, we designed a multi-centre phase-III trial delivering inhomogeneous dose...

  14. Advanced Wastewater Photo-oxidation System, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Pioneer Astronautics proposes an advanced photocatalytic oxidation reactor for enhancing the reliability and performance of Water Recovery Post Processing systems...

  15. Advanced conceptual design report solid waste retrieval facility, phase I, project W-113

    International Nuclear Information System (INIS)

    Smith, K.E.

    1994-01-01

    Project W-113 will provide the equipment and facilities necessary to retrieve suspect transuranic (TRU) waste from Trench 04 of the 218W-4C burial ground. As part of the retrieval process, waste drums will be assayed, overpacked, vented, head-gas sampled, and x-rayed prior to shipment to the Phase V storage facility in preparation for receipt at the Waste Receiving and Processing Facility (WRAP). Advanced Conceptual Design (ACD) studies focused on project items warranting further definition prior to Title I design and areas where the potential for cost savings existed. This ACD Report documents the studies performed during FY93 to optimize the equipment and facilities provided in relation to other SWOC facilities and to provide additional design information for Definitive Design

  16. The damper for the transverse instabilities of the SPS

    CERN Document Server

    Bossart, Rudolf; Gareyte, Jacques; de Raad, Bastiaan; Rossi, V

    1979-01-01

    For beam intensities above 10/sup 12/ protons per pulse in the SPS, collective transverse beam instabilities develop with frequencies between 15 kHz and 3 MHz because of the resistive wall effect of the vacuum chamber. An active feedback system with an electrostatic deflector has been installed in the SPS for damping the resistive wall instabilities in both the vertical and horizontal planes. Measurements have been made to determine the threshold and growth rate of these instabilities. As a novel application, the damper can be used also for the excitation of small coherent betatron oscillations. A phase-locked loop tracks the beam oscillations and provides a continuous display of the betatron wave-number Q during the cycle. (4 refs).

  17. Phase II study of safety and efficacy of motesanib in patients with progressive or symptomatic, advanced or metastatic medullary thyroid cancer

    DEFF Research Database (Denmark)

    Schlumberger, Martin J; Elisei, Rossella; Bastholt, Lars

    2009-01-01

    PURPOSE: This phase II study investigated the efficacy and tolerability of motesanib, an investigational, highly selective inhibitor of vascular endothelial growth factor receptors 1, 2, and 3; platelet-derived growth factor receptor; and Kit in advanced medullary thyroid cancer (MTC). PATIENTS A...

  18. Advanced Mars Water Acquisition System, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — The Advanced Mars Water Acquisition System (AMWAS) recovers and purifies water from Mars soils for oxygen and fuel production, life support, food production, and...

  19. Phase I study of single-agent ribociclib in Japanese patients with advanced solid tumors.

    Science.gov (United States)

    Doi, Toshihiko; Hewes, Becker; Kakizume, Tomoyuki; Tajima, Takeshi; Ishikawa, Norifumi; Yamada, Yasuhide

    2018-01-01

    The cyclin D-CDK4/6-INK4-Rb pathway is frequently dysregulated in cancers. Ribociclib, an orally available, selective CDK4/6 inhibitor, showed preliminary clinical activity in a phase I study in the USA and Europe for patients with solid tumors and lymphomas. The present study aimed to determine the single-agent maximum tolerated dose (MTD) and recommended dose for expansion (RDE) in Japanese patients with advanced solid tumors. Ribociclib safety, tolerability, pharmacokinetic profile, and preliminary antitumor activity were also assessed. Japanese patients with solid tumors that had progressed on prior therapies received escalating doses of single-agent ribociclib on a 3-weeks-on/1-week-off schedule. Treatment continued until the development of toxicity or disease progression. A dose escalation was planned for patients with esophageal cancer. In the dose-escalation phase, 4 patients received 400 mg ribociclib and 13 patients received 600 mg ribociclib. Four patients experienced dose-limiting toxicities, 3 of whom were in the 600 mg group. The RDE was declared to be 600 mg, and the MTD was not determined. The most frequent adverse events were hematologic and gastrointestinal. Four patients achieved stable disease at the 600 mg dose; no patients achieved complete or partial response. All patients discontinued the study, the majority due to disease progression. No patients discontinued due to adverse events. Dose escalation was not pursued due to lack of observed efficacy in esophageal cancer. At the RDE of 600 mg/d on a 3-weeks-on/1-week-off schedule, ribociclib showed acceptable safety and tolerability profiles in Japanese patients with advanced solid tumors. © 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

  20. Efficacy and safety of bevacizumab for the treatment of advanced hepatocellular carcinoma: a systematic review of phase II trials.

    Directory of Open Access Journals (Sweden)

    Ping Fang

    Full Text Available BACKGROUND: Hepatocellular carcinoma (HCC is a common cancer associated with a poor prognosis. Bevacizumab is a monoclonal antibody that binds vascular endothelial growth factor, a mediator of tumor angiogenesis. Bevacizumab is currently under investigation as treatment for HCC. We performed a systematic review of the efficacy and safety of bevacizumab for the treatment of advanced HCC. METHODS: PubMed, the Cochrane Library, and Google Scholar were searched using the terms "bevacizumab AND hepatocellular carcinoma AND (advanced OR unresectable". Phase II trials of bevacizumab for the treatment of advanced HCC were included. Outcomes of interest included progression-free and overall survival (PFS and OS, tumor response, and toxicities. RESULTS: A total of 26 records were identified. Of these, 18 were excluded. Hence, eight trials involving 300 patients were included. Bevacizumab was given as monotherapy (n = 1 trial or in combination with erlotinib (n = 4 trials, capecitabine (n = 1 trial, capecitabine+oxaliplatin (n = 1 trial, or gemcitabine+oxaliplatin (n = 1 trial. Most trials (five of eight reported median PFS and OS between 5.3 months and 9.0 months and 5.9 and 13.7 months, respectively. The disease control rate was consistent in five of eight trials, ranging from 51.1% to 76.9%. The response and partial response rates ranged from 0 to 23.7%, but were around 20% in four trials. Only one patient had a complete response. Frequently reported Grade 3/4 toxicities were increased aspartate transaminase/alanine transaminase (13%, fatigue (12%, hypertension (10%, diarrhea (8%, and neutropenia (5%. Thirty patients experienced gastrointestinal bleeding (grade 1/2 = 18, grade 3/4 = 12, typically due to esophageal varices. CONCLUSIONS: Bevacizumab shows promise as an effective and tolerable treatment for advanced HCC. The reported efficacy of bevacizumab appears to compare favorably with that of sorafenib, the only currently

  1. Reflooding phase after loss of coolant of an advanced pressurized water reactor with high conversion ratio

    International Nuclear Information System (INIS)

    Schumann, S.

    1984-01-01

    The emergency core cooling behaviour of an advanced pressurized water reactor (APWR) during the reflooding phase of the LOCA with double-ended break is analysed and compared to a common pressurized water reactor (PWR). The code FLUT-BS, its models and correlations are explained in detail and have been verified by numerous PWR-reflood experiments with large parameter range. The influence of core-design on ECC-behaviour as well as the influences of initial and boundary values are examined. The results show the essential differences of ECC-behaviour between PWR and APWR. (orig.) [de

  2. Intensity Modulated Radiotherapy (IMRT) in locally advanced thyroid cancer: Acute toxicity results of a phase I study

    International Nuclear Information System (INIS)

    Urbano, Teresa Guerrero; Clark, Catharine H.; Hansen, Vibeke N.; Adams, Elizabeth J.; Miles, Elizabeth A.; Mc Nair, Helen; Bidmead, A. Margaret; Warrington, Jim; Dearnaley, David P.; Harmer, Clive; Harrington, Kevin J.; Nutting, Christopher M.

    2007-01-01

    Background and purpose: This phase 1 study was designed to determine the toxicity of accelerated fractionation IMRT in locally advanced thyroid cancer. Methods: Patients with high risk locally advanced thyroid cancer who required post-operative EBRT were recruited. A single-phase inverse-planned-simultaneous-boost was delivered by IMRT: 58.8 Gy/28F (daily) to the primary tumour and involved nodes and 50 Gy/28F to the elective nodes. Acute (NCICTCv.2.0) and late toxicity (RTOG and modified LENTSOM) was collected. Results: Thirteen patients were treated (7 medullary thyroid, 2 Hurthle cell and 4 well differentiated thyroid cancer). G3 and G2 radiation dermatitis rates were 38.5% and 31%; G3 and G2 mucositis rates 8% and 53% and G3 and G2 pain 23% and 54%. Thirty-one percentage required enteral feeding. G3 and G2 xerostomia rates were 0% and 31%. Recovery was seen, with 62% patients having dysphagia G ≤ 1 2 months after IMRT. Thirty percent of patients developed L'Hermitte's syndrome. No grade 4 toxicity was observed. No dose limiting toxicity was found. Conclusions: Accelerated fractionation IMRT in this group of patients is feasible and safe. The acute toxicity appeared acceptable and early indicators of late toxicity moderate and similar to what would be expected with conventional RT. Longer follow up is required to quantify late side effects

  3. Advanced Pumps and Cold Plates for Two-Phase Cooling Loops, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Advanced instruments used for earth science missions require improved cooling systems to remove heat from high power electronic components and maintain tight...

  4. Advanced TCCS for Spacesuit Applications, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — A recent trade study showed that active removal of ammonia (NH3) and formaldehyde (CH2O) is crticial to meeting the 24-hr SMAC limits in the advanced space suit...

  5. Study Protocol: Phase III single-blinded fast-track pragmatic randomised controlled trial of a complex intervention for breathlessness in advanced disease

    Directory of Open Access Journals (Sweden)

    Brafman-Kennedy Barbara

    2011-05-01

    Full Text Available Abstract Background Breathlessness in advanced disease causes significant distress to patients and carers and presents management challenges to health care professionals. The Breathlessness Intervention Service (BIS seeks to improve the care of breathless patients with advanced disease (regardless of cause through the use of evidence-based practice and working with other healthcare providers. BIS delivers a complex intervention (of non-pharmacological and pharmacological treatments via a multi-professional team. BIS is being continuously developed and its impact evaluated using the MRC's framework for complex interventions (PreClinical, Phase I and Phase II completed. This paper presents the protocol for Phase III. Methods/Design Phase III comprises a pragmatic, fast-track, single-blind randomised controlled trial of BIS versus standard care. Due to differing disease trajectories, the service uses two broad service models: one for patients with malignant disease (intervention delivered over two weeks and one for patients with non-malignant disease (intervention delivered over four weeks. The Phase III trial therefore consists of two sub-protocols: one for patients with malignant conditions (four week protocol and one for patients with non-malignant conditions (eight week protocol. Mixed method interviews are conducted with patients and their lay carers at three to five measurement points depending on randomisation and sub-protocol. Qualitative interviews are conducted with referring and non-referring health care professionals (malignant disease protocol only. The primary outcome measure is 'patient distress due to breathlessness' measured on a numerical rating scale (0-10. The trial includes economic evaluation. Analysis will be on an intention to treat basis. Discussion This is the first evaluation of a breathlessness intervention for advanced disease to have followed the MRC framework and one of the first palliative care trials to use fast

  6. Advanced Simulation Capability for Environmental Management (ASCEM) Phase II Demonstration

    Energy Technology Data Exchange (ETDEWEB)

    Freshley, M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hubbard, S. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Flach, G. [Savannah River National Lab. (SRNL), Aiken, SC (United States); Freedman, V. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Agarwal, D. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Andre, B. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Bott, Y. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Chen, X. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Davis, J. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Faybishenko, B. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Gorton, I. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Murray, C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Moulton, D. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Meyer, J. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Rockhold, M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Shoshani, A. [LBNL; Steefel, C. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Wainwright, H. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Waichler, S. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2012-09-28

    In 2009, the National Academies of Science (NAS) reviewed and validated the U.S. Department of Energy Office of Environmental Management (EM) Technology Program in its publication, Advice on the Department of Energy’s Cleanup Technology Roadmap: Gaps and Bridges. The NAS report outlined prioritization needs for the Groundwater and Soil Remediation Roadmap, concluded that contaminant behavior in the subsurface is poorly understood, and recommended further research in this area as a high priority. To address this NAS concern, the EM Office of Site Restoration began supporting the development of the Advanced Simulation Capability for Environmental Management (ASCEM). ASCEM is a state-of-the-art scientific approach that uses an integration of toolsets for understanding and predicting contaminant fate and transport in natural and engineered systems. The ASCEM modeling toolset is modular and open source. It is divided into three thrust areas: Multi-Process High Performance Computing (HPC), Platform and Integrated Toolsets, and Site Applications. The ASCEM toolsets will facilitate integrated approaches to modeling and site characterization that enable robust and standardized assessments of performance and risk for EM cleanup and closure activities. During fiscal year 2012, the ASCEM project continued to make significant progress in capabilities development. Capability development occurred in both the Platform and Integrated Toolsets and Multi-Process HPC Simulator areas. The new Platform and Integrated Toolsets capabilities provide the user an interface and the tools necessary for end-to-end model development that includes conceptual model definition, data management for model input, model calibration and uncertainty analysis, and model output processing including visualization. The new HPC Simulator capabilities target increased functionality of process model representations, toolsets for interaction with the Platform, and model confidence testing and verification for

  7. Study of Second Phase Particles and Fe content in Zr Alloys Using the Advanced Photon Source at Argonne

    Energy Technology Data Exchange (ETDEWEB)

    Arthur T. Motta

    2001-11-07

    We have conducted a study of second phase particles and matrix alloying element concentrations in zirconium alloys using synchrotron radiation from the Advanced Photon Source (APS) at Argonne National Laboratory. The high flux of synchrotron radiation delivered at the 2BM beamline compared to conventional x-ray generators, enables the detection of very small precipitate volume fractions. We detected the standard C14 hcp Zr(Cr,Fe)2 precipitates, (the stable second phase in Zircaloy-4) in the bulk material at a cumulative annealing parameter as low as 10-20 h, and we followed the kinetics of precipitation and growth as a function of the cumulative annealing parameter (CAP) in the range 10-22 (quench) to 10-16 h. In addition, the unique combination of spatial resolution and elemental sensitivity of the 2ID-D/E microbeam line at the Advanced Photon Source at Argonne (APS) allows study of the alloying element concentrations at ppm levels in an area as small as 0.2 mm. We used x-ray fluorescence induced by this sub-micron x-ray beam to determine the concentration of these alloying elements in the matrix as a function of alloy type and thermal history. We discuss these results and the potential of synchrotron radiation-based techniques for studying zirconium alloys.

  8. Study of Second Phase Particles and Fe content in Zr Alloys Using the Advanced Photon Source at Argonne

    International Nuclear Information System (INIS)

    Motta, Arthur T.

    2001-01-01

    We have conducted a study of second phase particles and matrix alloying element concentrations in zirconium alloys using synchrotron radiation from the Advanced Photon Source (APS) at Argonne National Laboratory. The high flux of synchrotron radiation delivered at the 2BM beamline compared to conventional x-ray generators, enables the detection of very small precipitate volume fractions. We detected the standard C14 hcp Zr(Cr,Fe)2 precipitates, (the stable second phase in Zircaloy-4) in the bulk material at a cumulative annealing parameter as low as 10-20 h, and we followed the kinetics of precipitation and growth as a function of the cumulative annealing parameter (CAP) in the range 10-22 (quench) to 10-16 h. In addition, the unique combination of spatial resolution and elemental sensitivity of the 2ID-D/E microbeam line at the Advanced Photon Source at Argonne (APS) allows study of the alloying element concentrations at ppm levels in an area as small as 0.2 mm. We used x-ray fluorescence induced by this sub-micron x-ray beam to determine the concentration of these alloying elements in the matrix as a function of alloy type and thermal history. We discuss these results and the potential of synchrotron radiation-based techniques for studying zirconium alloys

  9. Phase tracking system for ultra narrow bandwidth applications

    NARCIS (Netherlands)

    Hill, M.T.; Cantoni, A.

    2002-01-01

    Recent advances make it possible to mitigate a number of drawbacks of conventional phase locked loops. These advances permit the design of phase tracking systems with much improved characteristics that are sought after in modern communication system applications. A new phase tracking system is

  10. Phase 2 Study of Bevacizumab Plus Erlotinib in Patients With Advanced Hepatocellular Cancer

    Science.gov (United States)

    Philip, Philip A.; Mahoney, Michelle R.; Holen, Kyle D.; Northfelt, Donald W.; Pitot, Henry C.; Picus, Joel; Flynn, Patrick J.; Erlichman, Charles

    2013-01-01

    BACKGROUND Epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) are rational targets for therapy in hepatocellular cancer (HCC). METHODS Patients with histologically proven HCC and not amenable to curative or liver directed therapy were included in this 2-stage phase 2 trial. Eligibility included an Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0 or 1 and Child’s Pugh score of A or B, and 1 prior systemic therapy. Patients received erlotinib 150 mg daily and bevacizumab 10 mg/kg on days 1 and 15 every 28 days. Objective tumor response was the primary end point. RESULTS Twenty-seven patients with advanced HCC (median age, 60 years) were enrolled in this multi-institutional study. The proportion of patients with Child’s A classification was 74%. One patient had a confirmed partial response and 11 (48%) achieved stable disease. Median time to disease progression was 3.0 months (95% confidence interval [CI], 1.8-7.1). Median survival time was 9.5 months (95% CI, 7.1-17.1). Grade 3 toxicities included rash, hypertension, fatigue, and diarrhea. CONCLUSIONS In this trial, erlotinib combined with bevacizumab had minimal activity in patients with advanced HCC based on objective response and progression-free survival. The role of targeting EGFR and VEGF in HCC needs further evaluation in molecularly selected patients. PMID:21953248

  11. A phase I, dose-escalation study of TB-403, a monoclonal antibody directed against PlGF, in patients with advanced solid tumours

    DEFF Research Database (Denmark)

    Lassen, U; Nielsen, D L; Sørensen, M

    2012-01-01

    BACKGROUND: TB-403 (RO 5323441), a humanised monoclonal antibody, is a novel antiangiogenesis agent directed against placental growth factor. The safety, pharmacokinetics (PK), and antitumour activity of TB-403 were assessed in a phase I, dose-escalation study in patients with advanced solid...

  12. Utility advanced turbine systems (ATS) technology readiness testing -- Phase 3. Annual report, October 1, 1996--September 30, 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-12-31

    The overall objective of the Advanced Turbine System (ATS) Phase 3 Cooperative Agreement between GE and the US Department of Energy (DOE) is the development of the GE 7H and 9H combined cycle power systems. The major effort will be expended on detail design. Validation of critical components and technologies will be performed including: hot gas path component testing, sub-scale compressor testing, steam purity test trials, and rotational heat transfer confirmation testing. Processes will be developed to support the manufacture of the first system. Technology enhancements that are not required for the first machine design but will be critical for future ATS advances in performance, reliability, and costs will be initiated. Long-term tests of materials to confirm design life predictions will continue. A schematic of the GE H machine is shown.

  13. Current pulse generator of an induction accelerator electromagnet

    International Nuclear Information System (INIS)

    Baginskij, B.A.; Makarevich, V.N.; Shtejn, M.M.

    1987-01-01

    Thyristor generator forming in betatron electromagnet coil sinusoidal and quasisinusoidal current unipolar pulses, the field being deforced at the beginning of acceleration cycle, and with the pulse flat top in the cycle end, is described. The current amplitude is controlled by pulse-phase method. The current pulse time shift permitted to decrease the loss rate in the accumulating capacitor. The generator is used in systems with 1-10 ms pulse duration, electromagnet magnetic field maximal energy - 45-450 J, the voltage amplitude in the coil 960-1500 V and amplitude of the current passing the coil 100-500 A, the repetition frequency being 50-200 Hz. In particular, the generator is used to supply betatrons designed for defectoscopy in nonstationary conditions, the accelerated electron energy being 4, 6, 8 and 15 MeV

  14. Orbit dynamics for unstable linear motion

    International Nuclear Information System (INIS)

    Parzen, G.

    1997-01-01

    A treatment is given of the orbit dynamics for linear unstable motion that allows for the zeros in the beta function and makes no assumptions about the realness of the betatron and phase functions. The phase shift per turn is shown to be related to the beta function and the number of zeros the beta function goes through per turn. The solutions of the equations of motion are found in terms of the beta function

  15. Orbit dynamics for unstable linear motion

    International Nuclear Information System (INIS)

    Parzen, G.

    1996-04-01

    A treatment is given of the orbit dynamics for linear unstable motion that allows for the zeros in the beta function and makes no assumption about the realness of the betatron and phase functions. The phase shift per turn is shown to be related to the beta function and the number of zeros the beta function goes through per turn. The solutions of the equations of motion are found in terms of the beta function

  16. A phase I/II clinical trial for the hybrid of intracavitary and interstitial brachytherapy for locally advanced cervical cancer.

    Science.gov (United States)

    Murakami, Naoya; Kato, Shingo; Nakano, Takashi; Uno, Takashi; Yamanaka, Takeharu; Sakurai, Hideyuki; Yoshimura, Ryoichi; Hiratsuka, Junichi; Kuroda, Yuki; Yoshio, Kotaro; Itami, Jun

    2016-08-17

    This paper describes about a study protocol of phase I/II multicenter prospective clinical trial evaluating the feasibility and efficacy of the hybrid of intracavitary and interstitial brachytherapy (HBT) for locally advanced uterine cervical cancer patients. Patients with histologically confirmed FIGO stage IB2, IIA2, IIB, and IIIB uterine cervical carcinoma width of which is larger than 5 cm assessed by MRI will be entered to this clinical trial. Protocol therapy is 30-30.6 Gy in 15-17 fractions of whole pelvic radiotherapy concurrent with weekly CDDP (40 mg/m(2)), followed by 24 Gy in 4 fractions of HBT and central shield EBRT up to 50-50.4 Gy in 25-28 fractions. Tumor width is assessed again within one week before the first HBT and if the tumor width is larger than 4 cm, patients proceed to the secondary registration. In phase I section, feasibility of this will be investigated. If less than 10 % out of 20 patients experienced greater than grade 3 acute non-hematologic adverse effects, the study proceeds to phase II part. In phase II part a total of 55 patients will be accrued and the efficacy of the HBT will be investigated comparing with historical control data. If the lower margin of 90 % confidence interval of the 2-year pelvic progression-free survival of the HBT trial is higher than 64 %, the HBT is considered to be more effective than conventional ICBT. The aim of this study is to demonstrate the feasibility and efficacy of the HBT for locally advanced cervical cancer. This trial will clarify the indication, feasibility, and efficacy of this new technique. UMIN000019081 ; Registration date: 2015/9/30.

  17. Advanced direct liquefaction concepts for PETC generic units. Final report, Phase I

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-03-01

    The Advanced Concepts for Direct Coal Liquefaction program was initiated by the Department of Energy in 1991 to develop technologies that could significantly reduce the cost of producing liquid fuels by the direct liquefaction of coal. The advanced 2-stage liquefaction technology that was developed at Wilsonville over the past 10 years has contributed significantly toward decreasing the cost of producing liquids from coal to about $33/bbl. It remains, however, the objective of DOE to further reduce this cost to a level more competitive with petroleum based products. This project, among others, was initiated to investigate various alternative approaches to develop technologies that might ultimately lead to a 25 % reduction in cost of product. In this project a number of novel concepts were investigated, either individually or in a coupled configuration that had the potential to contribute toward meeting the DOE goal. The concepts included mature technologies or ones closely related to them, such as coal cleaning by oil agglomeration, fluid coking and distillate hydrotreating and dewaxing. Other approaches that were either embryonic or less developed were chemical pretreatment of coal to remove oxygen, and dispersed catalyst development for application in the 2-stage liquefaction process. This report presents the results of this project. It is arranged in four sections which were prepared by participating organizations responsible for that phase of the project. A summary of the overall project and the principal results are given in this section. First, however, an overview of the process economics and the process concepts that were developed during the course of this program is presented.

  18. Schedule-selective biochemical modulation of 5-fluorouracil in advanced colorectal cancer – a phase II study

    Directory of Open Access Journals (Sweden)

    Savage Paul

    2002-05-01

    Full Text Available Abstract Background 5-fluorouracil remains the standard therapy for patients with advanced/metastatic colorectal cancer. Pre-clinical studies have demonstrated the biological modulation of 5-fluorouracil by methotrexate and leucovorin. This phase II study was initiated to determine the activity and toxicity of sequential methotrexate – leucovorin and 5-fluorouracil chemotherapy in patients with advanced colorectal cancer. Methods Ninety-seven patients with metastatic colorectal cancer were enrolled onto the study. Methotrexate – 30 mg/m2 was administered every 6 hours for 6 doses followed by a 2 hour infusion of LV – 500 mg/m2. Midway through the leucovorin infusion, patients received 5-fluorouracil – 600 mg/m2. This constituted a cycle of therapy and was repeated every 2 weeks until progression. Results The median age was 64 yrs (34–84 and the Eastern Cooperative Group Oncology performance score was 0 in 37%, 1 in 55% and 2 in 8% of patients. Partial and complete responses were seen in 31% of patients with a median duration of response of 6.4 months. The overall median survival was 13.0 months. The estimated 1-year survival was 53.7%. Grade III and IV toxic effects were modest and included mucositis, nausea and vomiting. Conclusions This phase II study supports previously reported data demonstrating the modest clinical benefit of 5-FU modulation utilizing methotrexate and leucovorin in patients with metastatic colorectal cancer. Ongoing studies evaluating 5-fluorouracil modulation with more novel agents (Irinotecan and/or oxaliplatin are in progress and may prove encouraging.

  19. Phase III Advanced Anodes and Cathodes Utilized in Energy Efficient Aluminum Production Cells; FINAL

    International Nuclear Information System (INIS)

    Christini, R.A.; Dawless, R.K.; Ray, S.P.; Weirauch, D.A. Jr.

    2001-01-01

    During Phase I of the present program, Alcoa developed a commercial cell concept that has been estimated to save 30% of the energy required for aluminum smelting. Phase ii involved the construction of a pilot facility and operation of two pilots. Phase iii of the Advanced Anodes and Cathodes Program was aimed at bench experiments to permit the resolution of certain questions to be followed by three pilot cells. All of the milestones related to materials, in particular metal purity, were attained with distinct improvements over work in previous phases of the program. NiO additions to the ceramic phase and Ag additions to the Cu metal phase of the cermet improved corrosion resistance sufficiently that the bench scale pencil anodes met the purity milestones. Some excellent metal purity results have been obtained with anodes of the following composition: Further improvements in anode material composition appear to be dependent on a better understanding of oxide solubilities in molten cryolite. For that reason, work was commissioned with an outside consultant to model the MeO - cryolite systems. That work has led to a better understanding of which oxides can be used to substitute into the NiO-Fe2O3 ceramic phase to stabilize the ferrites and reduce their solubility in molten cryolite. An extensive number of vertical plate bench electrolysis cells were run to try to find conditions where high current efficiencies could be attained. TiB2-G plates were very inconsistent and led to poor wetting and drainage. Pure TiB2 did produce good current efficiencies at small overlaps (shadowing) between the anodes and cathodes. This bench work with vertical plate anodes and cathodes reinforced the importance of good cathode wetting to attain high current efficiencies. Because of those conclusions, new wetting work was commissioned and became a major component of the research during the third year of Phase III. While significant progress was made in several areas, much work needs to be

  20. Advanced Gearless Drivetrain - Phase I Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Butterfield, Sandy; Smith, Jim; Petch, Derek; Sullivan, Brian; Smith, Peter; Pierce, Kirk

    2012-08-31

    Boulder Wind Power (BWP) collaborated with the National Renewable Energy Laboratory (NREL) in Golden, Colorado, to demonstrate the economics of scaling an advanced gearless drivetrain technology to 6MW (and larger) turbine applications. The project goal was to show that this advanced drivetrain technology enables a cost of energy of less than $0.10/kWH in offshore applications. This drivetrain technology achieves this Cost of Energy (COE) advantage via a 70% greater torque density versus current state-of-the-art drivetrain technologies. In addition, a new dynamically compliant design strategy is required to optimize turbine system-level COE. The BWP generator is uniquely suited for this new design strategy. This project developed a concept design for a 6MW drivetrain and culminated in a plan for a system-level test of this technology at 3MW scale. The project further demonstrated the advantage of the BWP drivetrain with increasing power ratings, with conceptual designs through 10 MW.

  1. Advanced supersonic propulsion study, phase 4

    Science.gov (United States)

    Howlett, R. A.

    1977-01-01

    Installation characteristics for a Variable Stream Control Engine (VSCE) were studied for three advanced supersonic airplane designs. Sensitivity of the VSCE concept to change in technology projections was evaluated in terms of impact on overall installed performance. Based on these sensitivity results, critical technology requirements were reviewed, resulting in the reaffirmation of the following requirements: low-noise nozzle system; a high performance, low emissions duct burner and main burner; hot section technology; variable geometry components; and propulsion integration features, including an integrated electronic control system.

  2. Body composition, symptoms, and survival in advanced cancer patients referred to a phase I service.

    Directory of Open Access Journals (Sweden)

    Henrique A Parsons

    Full Text Available Body weight and body composition are relevant to the outcomes of cancer and antineoplastic therapy. However, their role in Phase I clinical trial patients is unknown.We reviewed symptom burden, body composition, and survival in 104 patients with advanced cancer referred to a Phase I oncology service. Symptom burden was analyzed using the MD Anderson Symptom Assessment Inventory(MDASI; body composition was evaluated utilizing computerized tomography(CT images. A body mass index (BMI≥25 kg/m² was considered overweight. Sarcopenia, severe muscle depletion, was assessed using CT-based criteria.Most patients were overweight (n = 65, 63%; 53 patients were sarcopenic (51%, including 79% of patients with a BMI<25 kg/m² and 34% of those with BMI≥25 kg/m². Sarcopenic patients were older and less frequently African-American. Symptom burden did not differ among patients classified according to BMI and presence of sarcopenia. Median (95% confidence interval survival (days varied according to body composition: 215 (71-358 (BMI<25 kg/m²; sarcopenic, 271 (99-443 (BMI<25 kg/m²; non-sarcopenic, 484 (286-681 (BMI≥25 kg/m²; sarcopenic; 501 d (309-693 (BMI≥25 kg/m²; non-sarcopenic. Higher muscle index and gastrointestinal cancer diagnosis predicted longer survival in multivariate analysis after controlling for age, gender, performance status, and fat index.Patients referred to a Phase I clinic had a high frequency of sarcopenia and a BMI≥25 kg/m², independent of symptom burden. Body composition variables were predictive of clinically relevant survival differences, which is potentially important in developing Phase I studies.

  3. Regolith Advanced Surface Systems Operations Robot (RASSOR) Phase 2 and Smart Autonomous Sand-Swimming Excavator

    Science.gov (United States)

    Sandy, Michael

    2015-01-01

    The Regolith Advanced Surface Systems Operations Robot (RASSOR) Phase 2 is an excavation robot for mining regolith on a planet like Mars. The robot is programmed using the Robotic Operating System (ROS) and it also uses a physical simulation program called Gazebo. This internship focused on various functions of the program in order to make it a more professional and efficient robot. During the internship another project called the Smart Autonomous Sand-Swimming Excavator was worked on. This is a robot that is designed to dig through sand and extract sample material. The intern worked on programming the Sand-Swimming robot, and designing the electrical system to power and control the robot.

  4. Nano-Phase Powder Based Exothermic Braze Repair Technology For RCC Materials, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — The Phase II project will advance innovative, cost effective and reliable nano-phase exothermic RCC joining processes (ExoBrazeTM) in order to be able to reinforce...

  5. Advanced Technology MEMS-based Acoustic Array, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — The Interdisciplinary Consulting Corporation proposes a technological advancement of current state-of-the-art acoustic energy harvester for harsh environment...

  6. The long-term effects of phase advance shifts of photoperiod on cardiovascular parameters as measured by radiotelemetry in rats

    International Nuclear Information System (INIS)

    Molcan, L; Vesela, A; Zeman, M; Teplan, M

    2013-01-01

    Cardiovascular parameters, such as blood pressure and heart rate, exhibit both circadian and ultradian rhythms which are important for the adequate functioning of the system. For a better understanding of possible negative effects of chronodisruption on the cardiovascular system we studied circadian and ultradian rhythms of blood pressure and heart rate in rats exposed to repeated 8 h phase advance shifts of photoperiod. The experiment lasted 12 weeks, with three shifts per week. Spectral power as a function of frequency for both circadian and harmonic ultradian rhythms was expressed as the circadian–ultradian power ratio. The circadian rhythms of blood pressure, heart rate and locomotor activity were recorded during the control light:dark (LD) regimen with higher values during the D in comparison with the L. Phase advance shifts resulted in a diminished circadian–ultradian power ratio for blood pressure, heart rate and locomotor activity indicating suppressed circadian control of these traits greater in heart rate than blood pressure. In conclusion, rats kept under irregular LD conditions have suppressed circadian control of heart rate, blood pressure and locomotor activity and rely more on an acute response to the LD regime. Their ability to anticipate regular loads can be weakened and in this way chronodisruption can contribute to the pathogenesis of cardiovascular diseases. (paper)

  7. Phenobarbital blockade of the preovulatory luteinizing hormone surge: association with phase-advanced circadian clock and altered suprachiasmatic nucleus Period1 gene expression

    Science.gov (United States)

    Legan, Sandra J.; Donoghue, Kathleen M.; Franklin, Kathleen M.; Duncan, Marilyn J.

    2009-01-01

    The suprachiasmatic nucleus (SCN) controls the timing of the preovulatory luteinizing hormone (LH) surge in laboratory rodents. Barbiturate administration during a critical period on proestrus delays the surge and prolongs the estrous cycle 1 day. Because a nonphotic timing signal (zeitgeber) during the critical period that phase advances activity rhythms can also induce the latter effect, we hypothesized that barbiturates delay the LH surge by phase-advancing its circadian timing signal beyond the critical period. In experiment 1, locomotor rhythms and estrous cycles were monitored in hamsters for 2–3 wk preinjection and postinjection of vehicle or phenobarbital and after transfer to darkness at zeitgeber time (ZT) 6 on proestrus. Phenobarbital delayed estrous cycles in five of seven hamsters, which exhibited phase shifts that averaged twofold greater than those exhibited by vehicle controls or phenobarbital-injected hamsters with normal cycles. Experiment 2 used a similar protocol, but injections were at ZT 5, and blood samples for LH determination were collected from 1200 to 1800 on proestrus and the next day via jugular cannulae inserted the day before proestrus. Phenobarbital delayed the LH surge 1 day in all six hamsters, but it occurred at an earlier circadian time, supporting the above hypothesis. Experiment 3 investigated whether phenobarbital, like other nonphotic zeitgebers, suppresses SCN Period1 and Period2 transcription. Two hours postinjection, phenobarbital decreased SCN expression of only Period1 mRNA, as determined by in situ hybridization. These results suggest that phenobarbital advances the SCN pacemaker, governing activity rhythms and hormone release in part by decreasing its Period1 gene expression. PMID:19297538

  8. PowerGuard{reg_sign} Advanced Manufacturing; PVMaT Phase 1 Final Technical Report: June 1, 1998 to September 30, 1999

    Energy Technology Data Exchange (ETDEWEB)

    Marshall, M. C.; Dinwoodie, T. L.; O' Brian, C.; Botkin, J.; Ansley, J.

    2000-06-14

    During Phase 1 of PowerGuard{reg_sign} Advanced Manufacturing, PowerLight Corporation accomplished the following advancements: (1) Decreased system cost by 15%; (2) Increased PowerGuard tile production capacity from 5 MW/year to 8 MW/yr; (3) Established a manufacturing layout master plan for sequential integration of semi-automated and automated component workstations; (4) Defined semi-automation or automation of selected stages of the existing tile fabrication sequence, including PV module preparation, XPS processing, and coating; (5) Completed the advancement of several design improvements to the grid-tied inverter control board, including controller redesign, integrated data acquisition system (DAS), and communications for audit-worthy verification of PV system performance; (6) Conformed to NEPA, OSHA, and other federal and state regulations applicable to the proposed production process and mitigated potential for waste streams; (7) Initiated Underwriters Laboratories listings and international certifications on PowerGuard improvements; (8) Developed finance packages and integrated warranties; (9) Evaluated commercial demonstrations that incorporated the new design features and manufacturing process.

  9. Intensity-Modulated Whole Abdominal Radiotherapy After Surgery and Carboplatin/Taxane Chemotherapy for Advanced Ovarian Cancer: Phase I Study

    International Nuclear Information System (INIS)

    Rochet, Nathalie; Sterzing, Florian; Jensen, Alexandra D.; Dinkel, Julien; Herfarth, Klaus K.; Schubert, Kai; Eichbaum, Michael H.; Schneeweiss, Andreas; Sohn, Christof; Debus, Juergen; Harms, Wolfgang

    2010-01-01

    Purpose: To assess the feasibility and toxicity of consolidative intensity-modulated whole abdominal radiotherapy (WAR) after surgery and chemotherapy in high-risk patients with advanced ovarian cancer. Methods and Materials: Ten patients with optimally debulked ovarian cancer International Federation of Gynecology and Obstetrics Stage IIIc were treated in a Phase I study with intensity-modulated WAR up to a total dose of 30 Gy in 1.5-Gy fractions as consolidation therapy after adjuvant carboplatin/taxane chemotherapy. Treatment was delivered using intensity-modulated radiotherapy in a step-and-shoot technique (n = 3) or a helical tomotherapy technique (n = 7). The planning target volume included the entire peritoneal cavity and the pelvic and para-aortal node regions. Organs at risk were kidneys, liver, heart, vertebral bodies, and pelvic bones. Results: Intensity-modulated WAR resulted in an excellent coverage of the planning target volume and an effective sparing of the organs at risk. The treatment was well tolerated, and no severe Grade 4 acute side effects occurred. Common Toxicity Criteria Grade III toxicities were as follows: diarrhea (n = 1), thrombocytopenia (n = 1), and leukopenia (n = 3). Radiotherapy could be completed by all the patients without any toxicity-related interruption. Median follow-up was 23 months, and 4 patients had tumor recurrence (intraperitoneal progression, n = 3; hepatic metastasis, n = 1). Small bowel obstruction caused by adhesions occurred in 3 patients. Conclusions: The results of this Phase I study showed for the first time, to our knowledge, the clinical feasibility of intensity-modulated whole abdominal radiotherapy, which could offer a new therapeutic option for consolidation treatment of advanced ovarian carcinoma after adjuvant chemotherapy in selected subgroups of patients. We initiated a Phase II study to further evaluate the toxicity of this intensive multimodal treatment.

  10. Intensity-modulated whole abdominal radiotherapy after surgery and carboplatin/taxane chemotherapy for advanced ovarian cancer: phase I study.

    Science.gov (United States)

    Rochet, Nathalie; Sterzing, Florian; Jensen, Alexandra D; Dinkel, Julien; Herfarth, Klaus K; Schubert, Kai; Eichbaum, Michael H; Schneeweiss, Andreas; Sohn, Christof; Debus, Juergen; Harms, Wolfgang

    2010-04-01

    To assess the feasibility and toxicity of consolidative intensity-modulated whole abdominal radiotherapy (WAR) after surgery and chemotherapy in high-risk patients with advanced ovarian cancer. Ten patients with optimally debulked ovarian cancer International Federation of Gynecology and Obstetrics Stage IIIc were treated in a Phase I study with intensity-modulated WAR up to a total dose of 30 Gy in 1.5-Gy fractions as consolidation therapy after adjuvant carboplatin/taxane chemotherapy. Treatment was delivered using intensity-modulated radiotherapy in a step-and-shoot technique (n = 3) or a helical tomotherapy technique (n = 7). The planning target volume included the entire peritoneal cavity and the pelvic and para-aortal node regions. Organs at risk were kidneys, liver, heart, vertebral bodies, and pelvic bones. Intensity-modulated WAR resulted in an excellent coverage of the planning target volume and an effective sparing of the organs at risk. The treatment was well tolerated, and no severe Grade 4 acute side effects occurred. Common Toxicity Criteria Grade III toxicities were as follows: diarrhea (n = 1), thrombocytopenia (n = 1), and leukopenia (n = 3). Radiotherapy could be completed by all the patients without any toxicity-related interruption. Median follow-up was 23 months, and 4 patients had tumor recurrence (intraperitoneal progression, n = 3; hepatic metastasis, n = 1). Small bowel obstruction caused by adhesions occurred in 3 patients. The results of this Phase I study showed for the first time, to our knowledge, the clinical feasibility of intensity-modulated whole abdominal radiotherapy, which could offer a new therapeutic option for consolidation treatment of advanced ovarian carcinoma after adjuvant chemotherapy in selected subgroups of patients. We initiated a Phase II study to further evaluate the toxicity of this intensive multimodal treatment.

  11. First-in-Class, First-in-Human Phase I Study of Selinexor, a Selective Inhibitor of Nuclear Export, in Patients With Advanced Solid Tumors

    DEFF Research Database (Denmark)

    Abdul Razak, Albiruni R; Mau-Sørensen, Morten; Gabrail, Nashat Y

    2016-01-01

    PURPOSE: This trial evaluated the safety, pharmacokinetics, pharmacodynamics, and efficacy of selinexor (KPT-330), a novel, oral small-molecule inhibitor of exportin 1 (XPO1/CRM1), and determined the recommended phase II dose. PATIENTS AND METHODS: In total, 189 patients with advanced solid tumors...

  12. Advanced Vortex Hybrid Rocket Engine (AVHRE), Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Orbital Technologies Corporation (ORBITEC) proposes to develop a unique Advanced Vortex Hybrid Rocket Engine (AVHRE) to achieve a highly-reliable, low-cost and...

  13. The Vulcan Advanced Hybrid Manufacturing System, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Made In Space is developing the The Vulcan Advanced Hybrid Manufacturing System (VULCAN) to address NASA's requirement to produce high-strength, high-precision...

  14. Advanced Communication and Control for Distributed Energy Resource Integration: Phase 2 Scientific Report

    Energy Technology Data Exchange (ETDEWEB)

    BPL Global

    2008-09-30

    The objective of this research project is to demonstrate sensing, communication, information and control technologies to achieve a seamless integration of multivendor distributed energy resource (DER) units at aggregation levels that meet individual user requirements for facility operations (residential, commercial, industrial, manufacturing, etc.) and further serve as resource options for electric and natural gas utilities. The fully demonstrated DER aggregation system with embodiment of communication and control technologies will lead to real-time, interactive, customer-managed service networks to achieve greater customer value. Work on this Advanced Communication and Control Project (ACCP) consists of a two-phase approach for an integrated demonstration of communication and control technologies to achieve a seamless integration of DER units to reach progressive levels of aggregated power output. Phase I involved design and proof-of-design, and Phase II involves real-world demonstration of the Phase I design architecture. The scope of work for Phase II of this ACCP involves demonstrating the Phase I design architecture in large scale real-world settings while integrating with the operations of one or more electricity supplier feeder lines. The communication and control architectures for integrated demonstration shall encompass combinations of software and hardware components, including: sensors, data acquisition and communication systems, remote monitoring systems, metering (interval revenue, real-time), local and wide area networks, Web-based systems, smart controls, energy management/information systems with control and automation of building energy loads, and demand-response management with integration of real-time market pricing. For Phase II, BPL Global shall demonstrate the Phase I design for integrating and controlling the operation of more than 10 DER units, dispersed at various locations in one or more Independent System Operator (ISO) Control Areas, at

  15. A phase I/II study of neoadjuvant chemotherapy followed by radiation with boost chemotherapy for advanced T-stage nasopharyngeal carcinoma

    International Nuclear Information System (INIS)

    Johnson, Faye M.; Garden, Adam S.; Palmer, J. Lynn; Shin, Dong M.; Morrison, William; Papadimitrakopoulou, Vassiliki; Khuri, Fadlo; Clayman, Gary; Goepfert, Helmuth; Ang, K. Kian; Hong, Waun K.; Glisson, Bonnie S.

    2005-01-01

    Purpose: Local recurrence is the most common site of failure for locally advanced nasopharyngeal carcinoma (NPC) treated with neoadjuvant cisplatin/5-fluorouracil (PF) and definitive radiation at our center. Based on this, we studied the addition of chemotherapy during the boost phase of radiation after neoadjuvant PF for advanced T-stage (T3-T4) NPC. This strategy was based on theoretical radiosensitization with chemotherapy during accelerated repopulation of the tumor with relatively radioresistant clonogens. Methods and Materials: Three cycles of neoadjuvant PF was followed by conventionally fractionated radiation with additional PF during the boost portion of the radiation course. An initial Phase I study was done to establish the maximum tolerated dose of concurrent PF. Results: Forty-four patients were enrolled. Six patients in Phase I defined the MTD for concurrent PF as: cisplatin 10 mg/m 2 /day and PF 320 mg/m 2 /day, on Days 1-5 during Weeks 6 and 7 of radiation therapy based on dose-limiting toxicities of mucositis, neutropenia, and thrombocytopenia. Forty-one patients were treated with concurrent therapy per protocol: complete, partial, and minor responses were seen in 23, 16, and 2 patients, respectively. Progression-free and overall survival rates at 5 years were 55% (95% CI, 41-75%) and 66% (95% CI, 52-85%), respectively. Seven of 11 tumor-related deaths were due to local recurrence. Nine of 10 patients with local recurrence had T4-stage disease at presentation. Local control of T4 disease was achieved in 74% of patients overall, and in 25% (1/4) with World Health Organization (WHO) type 1, 76% (16/21) with WHO type 2, and 90% (9/10) with WHO type 3 histology. Common toxicities included mucositis, dermatitis, fatigue, vomiting, and weight loss. Conclusions: This regimen was feasible and associated with promising overall survival. Local recurrence remains the major reason for treatment failure in advanced T-stage NPC, especially WHO types 1 and 2

  16. Advanced Vortex Hybrid Rocket Engine (AVHRE), Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — ORBITEC proposes to develop a unique Advanced Vortex Hybrid Rocket Engine (AVHRE) to achieve a safe, highly-reliable, low-cost and uniquely versatile propulsion...

  17. Hot-working behavior of an advanced intermetallic multi-phase γ-TiAl based alloy

    Energy Technology Data Exchange (ETDEWEB)

    Schwaighofer, Emanuel, E-mail: emanuel.schwaighofer@unileoben.ac.at [Department of Physical Metallurgy and Materials Testing, Montanuniversität Leoben, Roseggerstr. 12, A-8700 Leoben (Austria); Clemens, Helmut [Department of Physical Metallurgy and Materials Testing, Montanuniversität Leoben, Roseggerstr. 12, A-8700 Leoben (Austria); Lindemann, Janny [Chair of Physical Metallurgy and Materials Technology, Brandenburg University of Technology, Konrad-Wachsmann-Allee 17, D-03046 Cottbus (Germany); GfE Fremat GmbH, Lessingstr. 41, D-09599 Freiberg (Germany); Stark, Andreas [Institute of Materials Research, Helmholtz-Zentrum Geesthacht, Max-Planck-Str. 1, D-21502 Geesthacht (Germany); Mayer, Svea [Department of Physical Metallurgy and Materials Testing, Montanuniversität Leoben, Roseggerstr. 12, A-8700 Leoben (Austria)

    2014-09-22

    New high-performance engine concepts for aerospace and automotive application enforce the development of lightweight intermetallic γ-TiAl based alloys with increased high-temperature capability above 750 °C. Besides an increased creep resistance, the alloy system must exhibit sufficient hot-workability. However, the majority of current high-creep resistant γ-TiAl based alloys suffer from poor workability, whereby grain refinement and microstructure control during hot-working are key factors to ensure a final microstructure with sufficient ductility and tolerance against brittle failure below the brittle-to-ductile transition temperature. Therefore, a new and advanced β-solidifying γ-TiAl based alloy, a so-called TNM alloy with a composition of Ti–43Al–4Nb–1Mo–0.1B (at%) and minor additions of C and Si, is investigated by means of uniaxial compressive hot-deformation tests performed with a Gleeble 3500 simulator within a temperature range of 1150–1300 °C and a strain rate regime of 0.005–0.5 s{sup −1} up to a true deformation of 0.9. The occurring mechanisms during hot-working were decoded by ensuing constitutive modeling of the flow curves by a novel phase field region-specific surface fitting approach via a hyperbolic-sine law as well as by evaluation through processing maps combined with microstructural post-analysis to determine a safe hot-working window of the refined TNM alloy. Complementary, in situ high energy X-ray diffraction experiments in combination with an adapted quenching and deformation dilatometer were conducted for a deeper insight about the deformation behavior of the alloy, i.e. phase fractions and texture evolution as well as temperature uncertainties arising during isothermal and non-isothermal compression. It was found that the presence of β-phase and the contribution of particle stimulated nucleation of ζ-Ti{sub 5}Si{sub 3} silicides and h-type carbides Ti{sub 2}AlC enhance the dynamic recrystallization behavior during

  18. Hot-working behavior of an advanced intermetallic multi-phase γ-TiAl based alloy

    International Nuclear Information System (INIS)

    Schwaighofer, Emanuel; Clemens, Helmut; Lindemann, Janny; Stark, Andreas; Mayer, Svea

    2014-01-01

    New high-performance engine concepts for aerospace and automotive application enforce the development of lightweight intermetallic γ-TiAl based alloys with increased high-temperature capability above 750 °C. Besides an increased creep resistance, the alloy system must exhibit sufficient hot-workability. However, the majority of current high-creep resistant γ-TiAl based alloys suffer from poor workability, whereby grain refinement and microstructure control during hot-working are key factors to ensure a final microstructure with sufficient ductility and tolerance against brittle failure below the brittle-to-ductile transition temperature. Therefore, a new and advanced β-solidifying γ-TiAl based alloy, a so-called TNM alloy with a composition of Ti–43Al–4Nb–1Mo–0.1B (at%) and minor additions of C and Si, is investigated by means of uniaxial compressive hot-deformation tests performed with a Gleeble 3500 simulator within a temperature range of 1150–1300 °C and a strain rate regime of 0.005–0.5 s −1 up to a true deformation of 0.9. The occurring mechanisms during hot-working were decoded by ensuing constitutive modeling of the flow curves by a novel phase field region-specific surface fitting approach via a hyperbolic-sine law as well as by evaluation through processing maps combined with microstructural post-analysis to determine a safe hot-working window of the refined TNM alloy. Complementary, in situ high energy X-ray diffraction experiments in combination with an adapted quenching and deformation dilatometer were conducted for a deeper insight about the deformation behavior of the alloy, i.e. phase fractions and texture evolution as well as temperature uncertainties arising during isothermal and non-isothermal compression. It was found that the presence of β-phase and the contribution of particle stimulated nucleation of ζ-Ti 5 Si 3 silicides and h-type carbides Ti 2 AlC enhance the dynamic recrystallization behavior during deformation within

  19. Recent Advances on Neuromorphic Systems Using Phase-Change Materials

    Science.gov (United States)

    Wang, Lei; Lu, Shu-Ren; Wen, Jing

    2017-05-01

    Realization of brain-like computer has always been human's ultimate dream. Today, the possibility of having this dream come true has been significantly boosted due to the advent of several emerging non-volatile memory devices. Within these innovative technologies, phase-change memory device has been commonly regarded as the most promising candidate to imitate the biological brain, owing to its excellent scalability, fast switching speed, and low energy consumption. In this context, a detailed review concerning the physical principles of the neuromorphic circuit using phase-change materials as well as a comprehensive introduction of the currently available phase-change neuromorphic prototypes becomes imperative for scientists to continuously progress the technology of artificial neural networks. In this paper, we first present the biological mechanism of human brain, followed by a brief discussion about physical properties of phase-change materials that recently receive a widespread application on non-volatile memory field. We then survey recent research on different types of neuromorphic circuits using phase-change materials in terms of their respective geometrical architecture and physical schemes to reproduce the biological events of human brain, in particular for spike-time-dependent plasticity. The relevant virtues and limitations of these devices are also evaluated. Finally, the future prospect of the neuromorphic circuit based on phase-change technologies is envisioned.

  20. Recent Advances on Neuromorphic Systems Using Phase-Change Materials.

    Science.gov (United States)

    Wang, Lei; Lu, Shu-Ren; Wen, Jing

    2017-12-01

    Realization of brain-like computer has always been human's ultimate dream. Today, the possibility of having this dream come true has been significantly boosted due to the advent of several emerging non-volatile memory devices. Within these innovative technologies, phase-change memory device has been commonly regarded as the most promising candidate to imitate the biological brain, owing to its excellent scalability, fast switching speed, and low energy consumption. In this context, a detailed review concerning the physical principles of the neuromorphic circuit using phase-change materials as well as a comprehensive introduction of the currently available phase-change neuromorphic prototypes becomes imperative for scientists to continuously progress the technology of artificial neural networks. In this paper, we first present the biological mechanism of human brain, followed by a brief discussion about physical properties of phase-change materials that recently receive a widespread application on non-volatile memory field. We then survey recent research on different types of neuromorphic circuits using phase-change materials in terms of their respective geometrical architecture and physical schemes to reproduce the biological events of human brain, in particular for spike-time-dependent plasticity. The relevant virtues and limitations of these devices are also evaluated. Finally, the future prospect of the neuromorphic circuit based on phase-change technologies is envisioned.

  1. Advanced Beamline Design for Fermilab's Advanced Superconducting Test Accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Prokop, Christopher [Northern Illinois Univ., DeKalb, IL (United States)

    2014-01-01

    The Advanced Superconducting Test Accelerator (ASTA) at Fermilab is a new electron accelerator currently in the commissioning stage. In addition to testing superconducting accelerating cavities for future accelerators, it is foreseen to support a variety of Advanced Accelerator R&D (AARD) experiments. Producing the required electron bunches with the expected flexibility is challenging. The goal of this dissertation is to explore via numerical simulations new accelerator beamlines that can enable the advanced manipulation of electron bunches. The work especially includes the design of a low-energy bunch compressor and a study of transverse-to-longitudinal phase space exchangers.

  2. Exatecan in pretreated adult patients with advanced soft tissue sarcoma: results of a phase II--study of the EORTC Soft Tissue and Bone Sarcoma Group

    DEFF Research Database (Denmark)

    Reichardt, P; Nielsen, Ole Steen; Bauer, S

    2007-01-01

    No standard treatment is established for patients with advanced soft tissue sarcoma after previous chemotherapy with anthracyclines and ifosfamide, given either in combination or sequentially. Exatecan (DX-8951f) is a totally synthetic analogue of the topoisomerase I-inhibitor camptothecin, which...... was synthesised to impart increased aqueous solubility, greater tumour efficacy, and less toxicity than camptothecin itself, topotecan or irinotecan. Since some activity against soft tissue sarcomas, especially leiomyosarcomas, has been reported for topoisomerase I-inhibitors, a study with a new and more potent...... agent seemed justified. We report on a prospective multicentre phase II study of Exatecan in adult soft tissue sarcomas failing 1 or 2 lines of chemotherapy in advanced phase, performed within the STBSG of EORTC. Thirty-nine patients (16 leiomyosarcomas and 23 other histologies) were included in two...

  3. Advanced 3D Object Identification System, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Optra will build an Advanced 3D Object Identification System utilizing three or more high resolution imagers spaced around a launch platform. Data from each imager...

  4. Anticipatory phase correction in sensorimotor synchronization.

    Science.gov (United States)

    Repp, Bruno H; Moseley, Gordon P

    2012-10-01

    Studies of phase correction in sensorimotor synchronization often introduce timing perturbations that are unpredictable with regard to direction, magnitude, and position in the stimulus sequence. If participants knew any or all of these parameters in advance, would they be able to anticipate perturbations and thus regain synchrony more quickly? In Experiment 1, we asked musically trained participants to tap in synchrony with short isochronous tone sequences containing a phase shift (PS) of -100, -40, 40, or 100 ms and provided advance information about its direction, position, or both (but not about its magnitude). The first two conditions had little effect, but in the third condition participants shifted their tap in anticipation of the PS, though only by about ±40 ms on average. The phase correction response to the residual PS was also enhanced. In Experiment 2, we provided complete advance information about PSs of various magnitudes either at the time of the immediately preceding tone ("late") or at the time of the tone one position back ("early") while also varying sequence tempo. Anticipatory phase correction was generally conservative and was impeded by fast tempo in the "late" condition. At fast tempi in both conditions, advancing a tap was more difficult than delaying a tap. The results indicate that temporal constraints on anticipatory phase correction resemble those on reactive phase correction. While the latter is usually automatic, this study shows that phase correction can also be controlled consciously for anticipatory purposes. Copyright © 2011 Elsevier B.V. All rights reserved.

  5. Advanced Power Plant Development and Analyses Methodologies

    Energy Technology Data Exchange (ETDEWEB)

    G.S. Samuelsen; A.D. Rao

    2006-02-06

    Under the sponsorship of the U.S. Department of Energy/National Energy Technology Laboratory, a multi-disciplinary team led by the Advanced Power and Energy Program of the University of California at Irvine is defining the system engineering issues associated with the integration of key components and subsystems into advanced power plant systems with goals of achieving high efficiency and minimized environmental impact while using fossil fuels. These power plant concepts include ''Zero Emission'' power plants and the ''FutureGen'' H{sub 2} co-production facilities. The study is broken down into three phases. Phase 1 of this study consisted of utilizing advanced technologies that are expected to be available in the ''Vision 21'' time frame such as mega scale fuel cell based hybrids. Phase 2 includes current state-of-the-art technologies and those expected to be deployed in the nearer term such as advanced gas turbines and high temperature membranes for separating gas species and advanced gasifier concepts. Phase 3 includes identification of gas turbine based cycles and engine configurations suitable to coal-based gasification applications and the conceptualization of the balance of plant technology, heat integration, and the bottoming cycle for analysis in a future study. Also included in Phase 3 is the task of acquiring/providing turbo-machinery in order to gather turbo-charger performance data that may be used to verify simulation models as well as establishing system design constraints. The results of these various investigations will serve as a guide for the U. S. Department of Energy in identifying the research areas and technologies that warrant further support.

  6. Advanced Power Plant Development and Analysis Methodologies

    Energy Technology Data Exchange (ETDEWEB)

    A.D. Rao; G.S. Samuelsen; F.L. Robson; B. Washom; S.G. Berenyi

    2006-06-30

    Under the sponsorship of the U.S. Department of Energy/National Energy Technology Laboratory, a multi-disciplinary team led by the Advanced Power and Energy Program of the University of California at Irvine is defining the system engineering issues associated with the integration of key components and subsystems into advanced power plant systems with goals of achieving high efficiency and minimized environmental impact while using fossil fuels. These power plant concepts include 'Zero Emission' power plants and the 'FutureGen' H2 co-production facilities. The study is broken down into three phases. Phase 1 of this study consisted of utilizing advanced technologies that are expected to be available in the 'Vision 21' time frame such as mega scale fuel cell based hybrids. Phase 2 includes current state-of-the-art technologies and those expected to be deployed in the nearer term such as advanced gas turbines and high temperature membranes for separating gas species and advanced gasifier concepts. Phase 3 includes identification of gas turbine based cycles and engine configurations suitable to coal-based gasification applications and the conceptualization of the balance of plant technology, heat integration, and the bottoming cycle for analysis in a future study. Also included in Phase 3 is the task of acquiring/providing turbo-machinery in order to gather turbo-charger performance data that may be used to verify simulation models as well as establishing system design constraints. The results of these various investigations will serve as a guide for the U. S. Department of Energy in identifying the research areas and technologies that warrant further support.

  7. Advances in the physics of radiation oncology - 50 years of contributions by US Medical Physicists

    International Nuclear Information System (INIS)

    Suntharalingam, N.

    2008-01-01

    Medical Physicists have a long standing record in the advancement of the discipline of Radiation Oncology, not only in the United States but world-wide, going back to the pre-world war II era. In the United States the contributions of Failla and Quimby, first at Memorial Hospital and then at Columbia University in New York, laid the foundation for the Profession of Medical Physics in the US. Radiation Therapy first used low and high kilovoltage machines for external beam therapy. Radium (Parker) and radon seeds (Quimby) were used for brachytherapy. Subsequently, clinical Van-de-Graaff machines (Trump and Wright) and the Betatron (Kerst, Adams and Skaggs) provided the required photon beams and also made available clinically useful electron beams. The work of John Laughlin, Larry Lanzl, Jacques Ovadia together with Gail Adams and Lester Skaggs, needs to be recognized for their pioneering efforts. With the introduction of Cobalt-60 Teletherapy (Harold Johns and the Canadian Group, Gilbert Fletcher and the MD Anderson Group) and Linear Accelerators (Henry Kaplan and the Stanford Group, and Varian), in the late 1950s ∼ 1960, there was even a greater need for the strong participation of medical physicists, as a useful technical resource to the physicians

  8. Gas phase ion chemistry

    CERN Document Server

    Bowers, Michael T

    1979-01-01

    Gas Phase Ion Chemistry, Volume 1 covers papers on the advances of gas phase ion chemistry. The book discusses the advances in flow tubes and the measurement of ion-molecule rate coefficients and product distributions; the ion chemistry of the earth's atmosphere; and the classical ion-molecule collision theory. The text also describes statistical methods in reaction dynamics; the state selection by photoion-photoelectron coincidence; and the effects of temperature and pressure in the kinetics of ion-molecule reactions. The energy distribution in the unimolecular decomposition of ions, as well

  9. Randomized phase III study comparing paclitaxel/cisplatin/gemcitabine and gemcitabine/cisplatin in patients with locally advanced or metastatic urothelial cancer without prior systemic therapy

    DEFF Research Database (Denmark)

    Bellmunt, Joaquim; von der Maase, Hans; Mead, Graham M

    2012-01-01

    The combination of gemcitabine plus cisplatin (GC) is a standard regimen in patients with locally advanced or metastatic urothelial cancer. A phase I/II study suggested that a three-drug regimen that included paclitaxel had greater antitumor activity and might improve survival....

  10. Advanced materials for future Phase II LHC collimators

    CERN Document Server

    Dallocchio, A; Arnau Izquierdo, G; Artoos, K

    2009-01-01

    Phase I collimators, equipped with Carbon-Carbon jaws, effectively met specifications for the early phase of LHC operation. However, the choice of carbon-based materials is expected to limit the nominal beam intensity mainly because of the high RF impedance and limited efficiency of the collimators. Moreover, C/C may be degraded by high radiation doses. To overcome these limitations, new Phase II secondary collimators will complement the existing system. Their extremely challenging requirements impose a thorough material investigation effort aiming at identifying novel materials combining very diverse properties. Relevant figures of merit have been identified to classify materials: Metal-diamonds composites look a promising choice as they combine good thermal, structural and stability properties. Molybdenum is interesting for its good thermal stability. Ceramics with non-conventional RF performances are also being evaluated. The challenges posed by the development and industrialization of these materials are ...

  11. Space-Ready Advanced Imaging System, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — In this Phase II effort Toyon will increase the state-of-the-art for video/image systems. This will include digital image compression algorithms as well as system...

  12. Application of digital beam position processor Libera on tune measurement

    International Nuclear Information System (INIS)

    Zhang Chunhui; Sun Baogen; Cao Yong; Lu Ping; Li Jihao

    2006-01-01

    Digital signal processing (DSP) is widely used in the field of beam diagnostics. Especially, DSP achieves very good performance in beam position signal analysis and betatron tune measurement. In Hefei light source, when beam was excited by narrow-band Gaussian white nose, Libera, a digital beam position processor, was used to process the signals from beam position monitor (BPM), which contained betatron oscillation. Fast Fourier transform (FFT) was applied to finding out betatron resonance frequency, from which the decimal part of betatron oscillation tune was calculated. By this means, the measure of horizontal tune was 3.5352 and the measure of vertical tune is 2.6299. (authors)

  13. Advanced worker protection system. Topical report, Phase I

    Energy Technology Data Exchange (ETDEWEB)

    Myers, J.

    1995-07-01

    The Department of Energy (DOE) is in the process of defining the magnitude and diversity of Decontamination and Decommissioning (D&D) obligations at its numerous sites. The DOE believes that existing technologies are inadequate to solve many challenging problems such as how to decontaminate structures and equipment cost effectively, what to do with materials and wastes generated, and how to adequately protect workers and the environment. Preliminary estimates show a tremendous need for effective use of resources over a relatively long period (over 30 years). Several technologies are being investigated which can potentially reduce D&D costs while providing appropriate protection to DOE workers. The DOE recognizes that traditional methods used by the EPA in hazardous waste site clean up activities are insufficient to provide the needed protection and worker productivity demanded by DOE D&D programs. As a consequence, new clothing and equipment which can adequately protect workers while providing increases in worker productivity are being sought for implementation at DOE sites. This project will result in the development of an Advanced Worker Protection System (AWPS). The AWPS will be built around a life support backpack that uses liquid air to provide cooling as well as breathing gas to the worker. The backpack will be combined with advanced protective garments, advanced liquid cooling garment, respirator, communications, and support equipment to provide improved worker protection, simplified system, maintenance, and dramatically improve worker productivity through longer duration work cycles.

  14. Advancing Astrophysics with the Square Kilometre Array

    CERN Document Server

    Fender, Rob; Govoni, Federica; Green, Jimi; Hoare, Melvin; Jarvis, Matt; Johnston-Hollitt, Melanie; Keane, Evan; Koopmans, Leon; Kramer, Michael; Maartens, Roy; Macquart, Jean-Pierre; Mellema, Garrelt; Oosterloo, Tom; Prandoni, Isabella; Pritchard, Jonathan; Santos, Mario; Seymour, Nick; Stappers, Ben; Staveley-Smith, Lister; Tian, Wen Wu; Umana, Grazia; Wagg, Jeff; Bourke, Tyler L; AASKA14

    2015-01-01

    In 2014 it was 10 years since the publication of the comprehensive ‘Science with the Square Kilometre Array’ book and 15 years since the first such volume appeared in 1999. In that time numerous and unexpected advances have been made in the fields of astronomy and physics relevant to the capabilities of the Square Kilometre Array (SKA). The SKA itself progressed from an idea to a developing reality with a baselined Phase 1 design (SKA1) and construction planned from 2017. To facilitate the publication of a new, updated science book, which will be relevant to the current astrophysical context, the meeting "Advancing Astrophysics with the Square Kilometre Array" was held in Giardina Naxos, Sicily. Articles were solicited from the community for that meeting to document the scientific advances enabled by the first phase of the SKA and those pertaining to future SKA deployments, with expected gains of 5 times the Phase 1 sensitivity below 350 MHz, about 10 times the Phase 1 sensitivity above 350 MHz and with f...

  15. A low vertical β mode for the LNLS UVX electron storage ring

    International Nuclear Information System (INIS)

    Lin, Liu; Tavares, P.

    1991-01-01

    An operation mode with low vertical betatron function in one of the long dispersion free straight sections of the LNLS UVX Electron Storage Ring is studied for applications with small gap insertions. The flexibility of this lattice is analyzed regarding two aspects: the range of variation of the vertical betatron tune and the ability to set the betatron functions to high/low values in the insertion straights

  16. A Phase I study of bizelesin (NSC 615291) in patients with advanced solid tumors.

    Science.gov (United States)

    Pitot, Henry C; Reid, Joel M; Sloan, Jeff A; Ames, Matthew M; Adjei, Alex A; Rubin, Joseph; Bagniewski, Pamela G; Atherton, Pamela; Rayson, Daniel; Goldberg, Richard M; Erlichman, Charles

    2002-03-01

    To evaluate the toxicities, characterize the pharmacokinetics, and determine the maximum-tolerated dose of bizelesin administered once every 4 weeks. Patients with advanced solid tumors received escalating doses of bizelesin as an i.v. push every 4 weeks. Pharmacokinetic studies were performed with the first treatment cycle. Nineteen eligible patients received a total of 54 courses of bizelesin at doses ranging from 0.1 to 1 microg/m(2). Dose-limiting toxicity of neutropenia was seen in 2 of 4 patients treated at the 1 microg/m(2) dose level. Nonhematological toxicity was generally mild with maximum toxicity being Phase II dose. The area under the concentration time curve increased in proportion to administered dose, and the clearance remained constant over the dose range studied. Correlation analysis demonstrated relationships between dose and area under the concentration with cycle 1 hematological parameters, including absolute neutrophil and leukocyte nadirs. Bizelesin administered every 4 weeks as an i.v. push is well tolerated with dose-limiting toxicity of neutropenia. The maximum-tolerated dose (and recommended Phase II dose) is 0.8 microg/m(2) administered once every 4 weeks.

  17. A phase I monotherapy study of RG7212, a first-in-class monoclonal antibody targeting TWEAK signaling in patients with advanced cancers

    DEFF Research Database (Denmark)

    Lassen, Ulrik N; Meulendijks, Didier; Siu, Lilian L

    2015-01-01

    activation. A phase I study of RG7212, a humanized anti-TWEAK IgG1κ monoclonal antibody, was conducted in patients with advanced solid tumors expressing Fn14. EXPERIMENTAL DESIGN: Dose escalations, over a 200- to 7,200-mg range, were performed with patients enrolled in weekly (QW), bi-weekly (Q2W), or every...

  18. Phase II trial of cisplatin in advanced or recurrent cancer of the vagina: a Gynecologic Oncology Group Study.

    Science.gov (United States)

    Thigpen, J T; Blessing, J A; Homesley, H D; Berek, J S; Creasman, W T

    1986-01-01

    Twenty-six patients with advanced or recurrent cancer of the vagina no longer amenable to control with surgery and/or radiotherapy were entered into a phase II study of cisplatin 50 mg/m2 intravenously every 3 weeks. Two were deemed ineligible because of a primary site of origin other than vagina. Two were deemed inevaluable, one because of the lack of measurable disease and the other because she never received drug. The remaining 22 included a variety of histologies (16 squamous cell carcinomas, 2 adenosquamous carcinomas, 1 clear cell carcinoma, 1 leiomyosarcoma, and 2 carcinomas not otherwise specified). One complete responder was observed among the 16 patients with squamous cell carcinoma. Adverse effects were tolerable and were essentially those reported in other series. These results suggest that cisplatin has insignificant activity in advanced or recurrent squamous cell carcinoma of the vagina at least at the dose and schedule tested. No comment can be made regarding the activity of cisplatin in other histologies.

  19. First-in-Human Phase 1 Trial of Agarose Beads Containing Murine RENCA Cells in Advanced Solid Tumors

    Directory of Open Access Journals (Sweden)

    Barry H. Smith

    2016-01-01

    Full Text Available Purpose Agarose macrobeads containing mouse renal adenocarcinoma cells (RMBs release factors, suppressing the growth of cancer cells and prolonging survival in spontaneous or induced tumor animals, mediated, in part, by increased levels of myocyte-enhancing factor (MEF2D via EGFR-and AKT-signaling pathways. The primary objective of this study was to determine the safety of RMBs in advanced, treatment-resistant metastatic cancers, and then its efficacy (survival, which is the secondary objective. Methods Thirty-one patients underwent up to four intraperitoneal implantations of RMBs (8 or 16 macrobeads/kg via laparoscopy in this single-arm trial (FDA BB-IND 10091; NCT 00283075. Serial physical examinations, laboratory testing, and PET-CT imaging were performed before and three months after each implant. Results RMBs were well tolerated at both dose levels (mean 660.9 per implant. AEs were (Grade 1/2 with no treatment-related SAEs. Conclusion The data support the safety of RMB therapy in advanced-malignancy patients, and the preliminary evidence for their potential efficacy is encouraging. A Phase 2 efficacy trial is ongoing.

  20. Advanced Collaborative Emissions Study (ACES)

    Energy Technology Data Exchange (ETDEWEB)

    Greenbaum, Daniel; Costantini, Maria; Van Erp, Annemoon; Shaikh, Rashid; Bailey, Brent; Tennant, Chris; Khalek, Imad; Mauderly, Joe; McDonald, Jacob; Zielinska, Barbara; Bemis, Jeffrey; Storey, John; Hallberg, Lance; Clark, Nigel

    2013-12-31

    The objective of the Advanced Collaborative Emissions Study (ACES) was to determine before widespread commercial deployment whether or not the new, energy-efficient, heavy duty diesel engines (2007 and 2010 EPA Emissions Standards Compliant) may generate anticipated toxic emissions that could adversely affect the environment and human health. ACES was planned to take place in three phases. In Phase 1, extensive emissions characterization of four production-intent prototype engine and control systems designed to meet 2007 standards for nitrogen oxides (NOx) and particulate matter (PM) was conducted at an existing emissions characterization facility: Southwest Research Institute (SwRI). One of the tested engines was selected (at random, after careful comparison of results) for health testing in Phase 3. In Phase 2, extensive emission characterization of three production-intent prototype engine and control systems meeting the 2010 standards (including more advanced NOx controls to meet the more stringent 2010 NOx standards) was conducted at the same test facility. In Phase 3, one engine/aftertreatment system selected from Phase 1 was further characterized during health effects studies (at an existing inhalation toxicology laboratory: Lovelace Respiratory Research Institute, [LRRI]) to form the basis of the ACES safety assessment. The Department of Energy (DOE) award provided funding for emissions characterization in Phases 1 and 2 as well as exposure characterization in Phase 3. The main health analyses in Phase 3 were funded separately and are not reported here.

  1. Phase II study of chemoradiotherapy for advanced squamous cell carcinoma of the thoracic esophagus. Nine Japanese institutions trial

    Energy Technology Data Exchange (ETDEWEB)

    Ishida, Kaoru [Iwate Medical Univ., Morioka (Japan). School of Medicine; Iizuka, Toshifumi; Ando, Nobutoshi; Ide, Hiroko

    1996-10-01

    A phase II study of chemoradiotherapy for advanced squamous cell carcinoma of the thoracic esophagus was carried out cooperatively by nine Japanese institutions. Forty-five patients with thoracic advanced squamous cell carcinoma, who had T4 tumor or distant lymph node metastasis (M1{sub (LYM)}), were enrolled in the study for treatment with cisplatin (70 mg/m{sup 2}) on days 1 and 36, and 5-fluorouracil infusion (700 mg/m{sup 2}) on days 1-4 and 36-39 sandwiched around external beam irradiation (60 Gy over 6 weeks). Of the 45 evaluable patients, 37 (84.1%) completed the treatment. The overall response rate was 64.4%, and the complete response rate 8.9%. The median duration of response was 125.0 days for patients who achieved complete and partial response. The 50% median survival time was 215 days. There was one toxicity-related death due to radiation pneumonitis. The major form of toxicity exceeding grade 2 was myelosuppression and anorexia, but grade 4 toxicity was also observed (2 pulmonary, 1 severe hypoxemia, 1 severe cardiac failure and 1 mental disturbance). The results showed that this form of chemoradiotherapy had a satisfactory effect and might be useful for treatment of inoperable advanced esophageal cancer. (author)

  2. Short-Course Accelerated Radiotherapy in Palliative Treatment of Advanced Pelvic Malignancies: A Phase I Study

    Energy Technology Data Exchange (ETDEWEB)

    Caravatta, Luciana [Department of Radiation Oncology, Fondazione di Ricercae Cura ' Giovanni Paolo II,' Universita Cattolica del S. Cuore, Campobasso (Italy); Padula, Gilbert D.A. [Department of Radiation Oncology, Lacks Cancer Center Saint Mary' s Health Care, Grand Rapids, MI (United States); Macchia, Gabriella, E-mail: gmacchia@rm.unicatt.it [Department of Radiation Oncology, Fondazione di Ricercae Cura ' Giovanni Paolo II,' Universita Cattolica del S. Cuore, Campobasso (Italy); Ferrandina, Gabriella [Department of Gynecologic Oncology, Fondazione di Ricercae Cura ' Giovanni Paolo II,' Universita Cattolica del S. Cuore, Campobasso (Italy); Bonomo, Pierluigi; Deodato, Francesco; Massaccesi, Mariangela [Department of Radiation Oncology, Fondazione di Ricercae Cura ' Giovanni Paolo II,' Universita Cattolica del S. Cuore, Campobasso (Italy); Mignogna, Samantha; Tambaro, Rosa [Department of Palliative Therapies, Fondazione di Ricercae Cura ' Giovanni Paolo II,' Universita Cattolica del S. Cuore, Campobasso (Italy); Rossi, Marco [Department of Anaesthesia, Intensive Care, and Pain Medicine, Fondazione di Ricercae Cura ' Giovanni Paolo II,' Universita Cattolica del S. Cuore, Campobasso (Italy); Flocco, Mariano [' Madre Teresa di Calcutta' Hospice, Larino (Italy); Scapati, Andrea [Department of Radiation Oncology, ' San Francesco' Hospital, Nuoro (Italy); and others

    2012-08-01

    Purpose: To define the maximum tolerated dose of a conformal short-course accelerated radiotherapy in patients with symptomatic advanced pelvic cancer. Methods and Materials: A phase I trial in 3 dose-escalation steps was designed: 14 Gy (3.5-Gy fractions), 16 Gy (4-Gy fractions), and 18 Gy (4.5-Gy fractions). The eligibility criteria included locally advanced and/or metastatic pelvic cancer and Eastern Cooperative Oncology Group performance status of {<=}3. Treatment was delivered in 2 days with twice-daily fractionation and at least an 8-hour interval. Patients were treated in cohorts of 6-12 to define the maximum tolerated dose. The dose-limiting toxicity was defined as any acute toxicity of grade 3 or greater, using the Radiation Therapy Oncology Group scale. Pain was recorded using a visual analog scale. The effect on quality of life was evaluated according to Cancer Linear Analog Scale (CLAS). Results: Of the 27 enrolled patients, 11 were male and 16 were female, with a median age of 72 years (range 47-86). The primary tumor sites were gynecologic (48%), colorectal (33.5%), and genitourinary (18.5%). The most frequent baseline symptoms were bleeding (48%) and pain (33%). Only grade 1-2 acute toxicities were recorded. No patients experienced dose-limiting toxicity. With a median follow-up time of 6 months (range 3-28), no late toxicities were observed. The overall (complete plus partial) symptom remission was 88.9% (95% confidence interval 66.0%-97.8%). Five patients (41.7%) had complete pain relief, and six (50%) showed >30% visual analog scale reduction. The overall response rate for pain was 91.67% (95% confidence interval 52.4%-99.9%). Conclusions: Conformal short course radiotherapy in twice-daily fractions for 2 consecutive days was well tolerated up to a total dose of 18 Gy. A phase II study is ongoing to confirm the efficacy on symptom control and quality of life indexes.

  3. Short-Course Accelerated Radiotherapy in Palliative Treatment of Advanced Pelvic Malignancies: A Phase I Study

    International Nuclear Information System (INIS)

    Caravatta, Luciana; Padula, Gilbert D.A.; Macchia, Gabriella; Ferrandina, Gabriella; Bonomo, Pierluigi; Deodato, Francesco; Massaccesi, Mariangela; Mignogna, Samantha; Tambaro, Rosa; Rossi, Marco; Flocco, Mariano; Scapati, Andrea

    2012-01-01

    Purpose: To define the maximum tolerated dose of a conformal short-course accelerated radiotherapy in patients with symptomatic advanced pelvic cancer. Methods and Materials: A phase I trial in 3 dose-escalation steps was designed: 14 Gy (3.5-Gy fractions), 16 Gy (4-Gy fractions), and 18 Gy (4.5-Gy fractions). The eligibility criteria included locally advanced and/or metastatic pelvic cancer and Eastern Cooperative Oncology Group performance status of ≤3. Treatment was delivered in 2 days with twice-daily fractionation and at least an 8-hour interval. Patients were treated in cohorts of 6-12 to define the maximum tolerated dose. The dose-limiting toxicity was defined as any acute toxicity of grade 3 or greater, using the Radiation Therapy Oncology Group scale. Pain was recorded using a visual analog scale. The effect on quality of life was evaluated according to Cancer Linear Analog Scale (CLAS). Results: Of the 27 enrolled patients, 11 were male and 16 were female, with a median age of 72 years (range 47-86). The primary tumor sites were gynecologic (48%), colorectal (33.5%), and genitourinary (18.5%). The most frequent baseline symptoms were bleeding (48%) and pain (33%). Only grade 1-2 acute toxicities were recorded. No patients experienced dose-limiting toxicity. With a median follow-up time of 6 months (range 3-28), no late toxicities were observed. The overall (complete plus partial) symptom remission was 88.9% (95% confidence interval 66.0%-97.8%). Five patients (41.7%) had complete pain relief, and six (50%) showed >30% visual analog scale reduction. The overall response rate for pain was 91.67% (95% confidence interval 52.4%-99.9%). Conclusions: Conformal short course radiotherapy in twice-daily fractions for 2 consecutive days was well tolerated up to a total dose of 18 Gy. A phase II study is ongoing to confirm the efficacy on symptom control and quality of life indexes.

  4. ADVANCED SIMULATION CAPABILITY FOR ENVIRONMENTAL MANAGEMENT- CURRENT STATUS AND PHASE II DEMONSTRATION RESULTS

    Energy Technology Data Exchange (ETDEWEB)

    Seitz, R.

    2013-02-26

    The U.S. Department of Energy (USDOE) Office of Environmental Management (EM), Office of Soil and Groundwater, is supporting development of the Advanced Simulation Capability for Environmental Management (ASCEM). ASCEM is a state-of-the-art scientific tool and approach for understanding and predicting contaminant fate and transport in natural and engineered systems. The modular and open source high-performance computing tool facilitates integrated approaches to modeling and site characterization that enable robust and standardized assessments of performance and risk for EM cleanup and closure activities. The ASCEM project continues to make significant progress in development of computer software capabilities with an emphasis on integration of capabilities in FY12. Capability development is occurring for both the Platform and Integrated Toolsets and High-Performance Computing (HPC) Multiprocess Simulator. The Platform capabilities provide the user interface and tools for end-to-end model development, starting with definition of the conceptual model, management of data for model input, model calibration and uncertainty analysis, and processing of model output, including visualization. The HPC capabilities target increased functionality of process model representations, toolsets for interaction with Platform, and verification and model confidence testing. The Platform and HPC capabilities are being tested and evaluated for EM applications in a set of demonstrations as part of Site Applications Thrust Area activities. The Phase I demonstration focusing on individual capabilities of the initial toolsets was completed in 2010. The Phase II demonstration completed in 2012 focused on showcasing integrated ASCEM capabilities. For Phase II, the Hanford Site deep vadose zone (BC Cribs) served as an application site for an end-to-end demonstration of capabilities, with emphasis on integration and linkages between the Platform and HPC components. Other demonstrations

  5. Advanced LIGO: sources and astrophysics

    International Nuclear Information System (INIS)

    Creighton, Teviet

    2003-01-01

    Second-generation detectors in LIGO will take us from the discovery phase of gravitational-wave observations to the phase of true gravitational-wave astrophysics, with hundreds or thousands of potential sources. This paper surveys the most likely and interesting potential sources for Advanced LIGO, and the astrophysical processes that each one will probe. I conclude that binary inspiral signals are expected, while continuous signals from pulsars are plausible but not guaranteed. Other sources, such as core-collapse bursts, cosmic strings and primordial stochastic backgrounds, are speculative sources for Advanced LIGO, but also potentially the most interesting, since they push the limits of our theoretical knowledge

  6. Phase 1 environmental report for the Advanced Neutron Source at Oak Ridge National Laboratory

    International Nuclear Information System (INIS)

    Blasing, T.J.; Brown, R.A.; Cada, G.F.; Easterly, C.; Feldman, D.L.; Hagan, C.W.; Harrington, R.M.; Johnson, R.O.; Ketelle, R.H.; Kroodsma, R.L.; McCold, L.N.; Reich, W.J.; Scofield, P.A.; Socolof, M.L.; Taleyarkhan, R.P.; Van Dyke, J.W.

    1992-02-01

    The US Department of Energy (DOE) has proposed the construction and operation of the Advanced Neutron Source (ANS), a 330-MW(f) reactor, at Oak Ridge National Laboratory (ORNL) to support neutron scattering and nuclear physics experiments. ANS would provide a steady-state source of neutrons that are thermalized to produce sources of hot, cold, and very coal neutrons. The use of these neutrons in ANS experiment facilities would be an essential component of national research efforts in basic materials science. Additionally, ANS capabilities would include production of transplutonium isotopes, irradiation of potential fusion and fission reactor materials, activation analysis, and production of medical and industrial isotopes such as 252 Cf. Although ANS would not require licensing by the US Nuclear Regulatory Commission (NRC), DOE regards the design, construction, and operation of ANS as activities that would produce a licensable facility; that is, DOE is following the regulatory guidelines that NRC would apply if NRC were licensing the facility. Those guidelines include instructions for the preparation of an environmental report (ER), a compilation of available data and preliminary analyses regarding the environmental impacts of nuclear facility construction and operation. The ER, described and outlined in NRC Regulatory Guide 4.2, serves as a background document to facilitate the preparation of environmental impact statements (EISs). Using Regulatory Guide 4.2 as a model, this ANS ER provides analyses and information specific to the ANS site and area that can be adopted (and modified, if necessary) for the ANS EIS. The ER is being prepared in two phases. Phase 1 ER includes many of the data and analyses needed to prepare the EIS but does not include data or analyses of alternate sites or alternate technologies. Phase 2 ER will include the additional data and analyses stipulated by Regulatory Guide 4.2

  7. Phase 1 environmental report for the Advanced Neutron Source at Oak Ridge National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Blasing, T.J.; Brown, R.A.; Cada, G.F.; Easterly, C.; Feldman, D.L.; Hagan, C.W.; Harrington, R.M.; Johnson, R.O.; Ketelle, R.H.; Kroodsma, R.L.; McCold, L.N.; Reich, W.J.; Scofield, P.A.; Socolof, M.L.; Taleyarkhan, R.P.; Van Dyke, J.W.

    1992-02-01

    The US Department of Energy (DOE) has proposed the construction and operation of the Advanced Neutron Source (ANS), a 330-MW(f) reactor, at Oak Ridge National Laboratory (ORNL) to support neutron scattering and nuclear physics experiments. ANS would provide a steady-state source of neutrons that are thermalized to produce sources of hot, cold, and very coal neutrons. The use of these neutrons in ANS experiment facilities would be an essential component of national research efforts in basic materials science. Additionally, ANS capabilities would include production of transplutonium isotopes, irradiation of potential fusion and fission reactor materials, activation analysis, and production of medical and industrial isotopes such as {sup 252}Cf. Although ANS would not require licensing by the US Nuclear Regulatory Commission (NRC), DOE regards the design, construction, and operation of ANS as activities that would produce a licensable facility; that is, DOE is following the regulatory guidelines that NRC would apply if NRC were licensing the facility. Those guidelines include instructions for the preparation of an environmental report (ER), a compilation of available data and preliminary analyses regarding the environmental impacts of nuclear facility construction and operation. The ER, described and outlined in NRC Regulatory Guide 4.2, serves as a background document to facilitate the preparation of environmental impact statements (EISs). Using Regulatory Guide 4.2 as a model, this ANS ER provides analyses and information specific to the ANS site and area that can be adopted (and modified, if necessary) for the ANS EIS. The ER is being prepared in two phases. Phase 1 ER includes many of the data and analyses needed to prepare the EIS but does not include data or analyses of alternate sites or alternate technologies. Phase 2 ER will include the additional data and analyses stipulated by Regulatory Guide 4.2.

  8. A phase I dose-escalation study of lenalidomide in combination with gemcitabine in patients with advanced pancreatic cancer.

    Directory of Open Access Journals (Sweden)

    Gustav J Ullenhag

    Full Text Available Lenalidomide have both immunomodulatory and anti-angiogenic properties which could confer anti-cancer effects. The aim of this study was to assess the feasibility of combining lenalidomide with the standard treatment gemcitabine in pancreatic cancer patients with advanced disease.Eligible patients had locally advanced or metastatic adenocarcinoma of the pancreas. Patients received lenalidomide days 1-21 orally and gemcitabine 1000 mg/m2 intravenously (days 1, 8 and 15, each 28 day cycle. Three cohorts of lenalidomide were examined (Cohort I = 15 mg, Cohort II = 20 mg and Cohort III = 25 mg daily. The maximum tolerated dose (MTD of lenalidomide given in combination with gemcitabine was defined as the highest dose level at which no more than one out of four (25% subjects experiences a dose-limiting toxicity (DLT. Patients should also be able to receive daily low molecular weight heparin (LMWH (e.g. dalteparin 5000 IU s.c. daily as a prophylactic anticoagulant for venous thromboembolic events (VTEs. Twelve patients (n = 4, n = 3 and n = 5 in cohort I, II and III, respectively were enrolled in this study.Median duration of treatment was 11 weeks (range 1-66, and median number of treatment cycles were three (range 1-14. The only DLT was a cardiac failure grade 3 in cohort III. Frequent treatment-related adverse events (AEs (all grades included neutropenia, leucopenia and fatigue (83% each, but there was no febrile neutropenia; thrombocytopenia (75%; dermatological toxicity (75%; diarrhea and nausea (42% each; and neuropathy (42%.This phase I study demonstrates the feasibility of the combination of lenalidomide and gemcitabine as first-line treatment in patients with advanced pancreatic cancer. The tolerability profile demonstrated in the dose escalation schedule of lenalidomide suggests the dosing of lenalidomide to be 25 mg daily on days 1-21 with standard dosing of gemcitabine and merits further evaluation in a phase II trial.ClinicalTrials.gov NCT

  9. A phase Ib study of pembrolizumab plus chemotherapy in patients with advanced cancer (PembroPlus).

    Science.gov (United States)

    Weiss, Glen J; Waypa, Jordan; Blaydorn, Lisa; Coats, Jessica; McGahey, Kayla; Sangal, Ashish; Niu, Jiaxin; Lynch, Cynthia A; Farley, John H; Khemka, Vivek

    2017-06-27

    Pembrolizumab (P) is an anti-PD-1 antibody that blocks the interaction between programmed cell death protein 1 (PD-1) on T-cells and PD-L1 and PD-L2 on tumour cells. A phase Ib trial of P plus chemotherapy was undertaken to evaluate the safety and efficacy. Patients with advanced, metastatic solid tumours were enrolled onto one of six treatment arms. Pembrolizumab was given: with gemcitabine (G), G+docetaxel (D), G+nab-paclitaxel (NP), G+vinorelbine (V) or irinotecan (I) until progression or toxicity, or with liposomal doxorubicin (LD) for up to 15 cycles, progression or toxicity. Safety monitoring and response assessments were conducted. Forty-nine patients were enrolled and treated. The most common adverse events were transaminitis, cytopenias, rash, diarrhoea, fatigue, nausea and vomiting. Arm 2 was closed due to poor accrual. The recommended phase II dose (RP2D) was determined for Arms 1, 3a, 4, 5 and 6. There were eight partial responses across multiple tumour types. Standard dose P can be safely combined with G, G+NP, G+V, I and LD. Efficacy was observed in multiple tumour types and evaluation to determine if response and duration of response are more robust than what would be expected for chemotherapy or immunotherapy alone requires further validation.

  10. Safety profile of avelumab in patients with advanced solid tumors: A pooled analysis of data from the phase 1 JAVELIN solid tumor and phase 2 JAVELIN Merkel 200 clinical trials

    OpenAIRE

    Kelly, K; Infante, JR; Taylor, MH; Patel, MR; Wong, DJ; Iannotti, N; Mehnert, JM; Loos, AH; Koch, H; Speit, I; Gulley, JL

    2018-01-01

    © 2018 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society. BACKGROUND: Antibodies targeting the programmed death-ligand 1 (PD-L1)/programmed cell death protein 1 (PD-1) checkpoint may cause adverse events (AEs) that are linked to the mechanism of action of this therapeutic class and unique from those observed with conventional chemotherapy. METHODS: Patients with advanced solid tumors who were enrolled in the phase 1 JAVELIN Solid Tumor (1650 patient...

  11. Phase I and pharmacodynamic study of vorinostat combined with capecitabine and cisplatin as first-line chemotherapy in advanced gastric cancer.

    Science.gov (United States)

    Yoo, Changhoon; Ryu, Min-Hee; Na, Young-Soon; Ryoo, Baek-Yeol; Lee, Chae-Won; Maeng, Jeheon; Kim, Se-Yeon; Koo, Dong Hoe; Park, Inkeun; Kang, Yoon-Koo

    2014-04-01

    A phase I trial of first-line vorinostat, an orally bio-available histone deacetylase inhibitor, in combination with capecitabine plus cisplatin (XP) was performed to assess recommend phase II trial dose in patients with advanced gastric cancer. Five dose levels of three-weekly vorinostat-XP were tested; vorinostat was dosed at 300-400 mg once daily on Days 1-14, capecitabine at 800-1,000 mg/m(2) twice daily on Days 1-14, and cisplatin at 60-80 mg/m(2) on Day 1. To assess the pharmacodynamics of vorinostat, histone H3 acetylation was assessed in peripheral blood mononuclear cells before the study treatment and at Day 8 of cycle 1. In total, 30 patients with unresectable or metastatic gastric adenocarcinoma were included. Dose-limiting toxicities were thrombocytopenia, fatigue, stomatitis, and anorexia. The following doses were recommended for phase II trial: 400 mg of vorinostat once daily, 1,000 mg/m(2) of capecitabine twice daily, and 60 mg/m(2) of cisplatin. The most common grade 3-4 toxicities were neutropenia (47 %), anorexia (20 %), thrombocytopenia (17 %), and fatigue (13 %). In overall, response rate was 56 % (95 % confidence interval [CI]: 32-81). With a median follow-up of 14.1 months, the median progression-free survival and overall survival were 7.1 months (95 % CI: 3.8-10.3) and 18.0 months (95 % CI: 4.8-31.1), respectively. The change in H3 acetylation after treatment with vorinostat correlated significantly with the vorinostat dose (300 vs. 400 mg/day) and the baseline level of H3 acetylation before treatment. Three-weekly vorinostat-XP regimen is feasible and recommended for further development in advanced gastric cancer.

  12. A phase IIb multicentre study comparing the efficacy of trabectedin to doxorubicin in patients with advanced or metastatic untreated soft tissue sarcoma: The TRUSTS trial

    NARCIS (Netherlands)

    Bui-Nguyen, B.; Butrynski, J.E.; Penel, N.; Blay, J.Y.; Isambert, N.; Milhem, M.; Kerst, J.M.; Reyners, A.K.; Litiere, S.; Marreaud, S.; Collin, F.; Graaf, W.T.A. van der

    2015-01-01

    PURPOSE: To evaluate whether trabectedin as first-line chemotherapy for advanced/metastatic soft tissue sarcoma prolongs progression-free survival (PFS), compared to doxorubicin and, in the phase IIb part here, to select the most appropriate trabectedin treatment schedule (3-hour or 24-hour

  13. Comparison of high-accuracy numerical simulations of black-hole binaries with stationary-phase post-Newtonian template waveforms for initial and advanced LIGO

    International Nuclear Information System (INIS)

    Boyle, Michael; Brown, Duncan A; Pekowsky, Larne

    2009-01-01

    We study the effectiveness of stationary-phase approximated post-Newtonian waveforms currently used by ground-based gravitational-wave detectors to search for the coalescence of binary black holes by comparing them to an accurate waveform obtained from numerical simulation of an equal-mass non-spinning binary black hole inspiral, merger and ringdown. We perform this study for the initial- and advanced-LIGO detectors. We find that overlaps between the templates and signal can be improved by integrating the match filter to higher frequencies than used currently. We propose simple analytic frequency cutoffs for both initial and advanced LIGO, which achieve nearly optimal matches, and can easily be extended to unequal-mass, spinning systems. We also find that templates that include terms in the phase evolution up to 3.5 post-Newtonian (pN) order are nearly always better, and rarely significantly worse, than 2.0 pN templates currently in use. For initial LIGO we recommend a strategy using templates that include a recently introduced pseudo-4.0 pN term in the low-mass (M ≤ 35 M o-dot ) region, and 3.5 pN templates allowing unphysical values of the symmetric reduced mass η above this. This strategy always achieves overlaps within 0.3% of the optimum, for the data used here. For advanced LIGO we recommend a strategy using 3.5 pN templates up to M = 12 M o-dot , 2.0 pN templates up to M = 21 M o-dot , pseudo-4.0 pN templates up to 65 M o-dot , and 3.5 pN templates with unphysical η for higher masses. This strategy always achieves overlaps within 0.7% of the optimum for advanced LIGO.

  14. Everolimus for Advanced Pancreatic Neuroendocrine Tumors.

    NARCIS (Netherlands)

    Yao, James C.; Shah, Manisha H.; Ito, Tetsuhide; Bohas, Catherine Lombard; Wolin, Edward M.; Van Cutsem, Eric; Hobday, Timothy J.; Okusaka, Takuji; Capdevila, Jaume; de Vries, Elisabeth G. E.; Tomassetti, Paola; Pavel, Marianne E.; Hoosen, Sakina; Haas, Tomas; Lincy, Jeremie; Lebwohl, David; Oberg, Kjell

    2011-01-01

    Background: Everolimus, an oral inhibitor of mammalian target of rapamycin (mTOR), has shown antitumor activity in patients with advanced pancreatic neuroendocrine tumors, in two phase 2 studies. We evaluated the agent in a prospective, randomized, phase 3 study. Methods: We randomly assigned 410

  15. NATO Advanced Study Institute on Advances in Chemical Reaction Dynamics

    CERN Document Server

    Capellos, Christos

    1986-01-01

    This book contains the formal lectures and contributed papers presented at the NATO Advanced Study Institute on. the Advances in Chemical Reaction Dynamics. The meeting convened at the city of Iraklion, Crete, Greece on 25 August 1985 and continued to 7 September 1985. The material presented describes the fundamental and recent advances in experimental and theoretical aspects of, reaction dynamics. A large section is devoted to electronically excited states, ionic species, and free radicals, relevant to chemical sys­ tems. In addition recent advances in gas phase polymerization, formation of clusters, and energy release processes in energetic materials were presented. Selected papers deal with topics such as the dynamics of electric field effects in low polar solutions, high electric field perturbations and relaxation of dipole equilibria, correlation in picosecond/laser pulse scattering, and applications to fast reaction dynamics. Picosecond transient Raman spectroscopy which has been used for the elucidati...

  16. Advanced frequency synthesis by phase lock

    CERN Document Server

    Egan, William F

    2011-01-01

    "An addendum to the popular Frequency Synthesis by Phase Lock, 2nd ed, this book describes sigma-delta, a frequency synthesis technique that has gained prominence in recent years. In addition, Simulink will be employed extensively to guide the reader. Fractional-n, the still-used forerunner to sigma-delta, is also discussed. Sequences of simulated results allow the reader to gain a deeper understanding while detailed appendices provide information from various stages of development. Simulation models discussed in the chapters that are available online."--Provided by publisher.

  17. Gas phase ion chemistry

    CERN Document Server

    Bowers, Michael T

    1979-01-01

    Gas Phase Ion Chemistry, Volume 2 covers the advances in gas phase ion chemistry. The book discusses the stabilities of positive ions from equilibrium gas-phase basicity measurements; the experimental methods used to determine molecular electron affinities, specifically photoelectron spectroscopy, photodetachment spectroscopy, charge transfer, and collisional ionization; and the gas-phase acidity scale. The text also describes the basis of the technique of chemical ionization mass spectrometry; the energetics and mechanisms of unimolecular reactions of positive ions; and the photodissociation

  18. Results from a Phase I Study of Lapatinib with Gemcitabine and Cisplatin in Advanced or Metastatic Bladder Cancer

    DEFF Research Database (Denmark)

    Cerbone, L; Sternberg, C N; Sengeløv, L

    2016-01-01

    BACKGROUND/OBJECTIVE: Lapatinib is a potent HER1 and HER2 inhibitor. Gemcitabine-cisplatin (GC) is a standard chemotherapy regimen for advanced/metastatic bladder cancer. This phase I study examined the safety of lapatinib in combination with GC in patients with bladder cancer. The primary aim...... × 3 patients), 1 of the 6 patients presented DLTs (grade 4, treatment-related febrile neutropenia and renal failure). Twelve patients received 6 cycles. CONCLUSIONS: Lapatinib at 750-1,250 mg combined with GC appears safe and tolerable. The MTD of lapatinib combined with GC in bladder cancer was 1...

  19. Phased Array Ultrasonic Inspection of Titanium Forgings

    International Nuclear Information System (INIS)

    Howard, P.; Klaassen, R.; Kurkcu, N.; Barshinger, J.; Chalek, C.; Nieters, E.; Sun, Zongqi; Fromont, F. de

    2007-01-01

    Aerospace forging inspections typically use multiple, subsurface-focused sound beams in combination with digital C-scan image acquisition and display. Traditionally, forging inspections have been implemented using multiple single element, fixed focused transducers. Recent advances in phased array technology have made it possible to perform an equivalent inspection using a single phased array transducer. General Electric has developed a system to perform titanium forging inspection based on medical phased array technology and advanced image processing techniques. The components of that system and system performance for titanium inspection will be discussed

  20. TP Atlas: integration and dissemination of advances in Targeted Proteins Research Program (TPRP)-structural biology project phase II in Japan.

    Science.gov (United States)

    Iwayanagi, Takao; Miyamoto, Sei; Konno, Takeshi; Mizutani, Hisashi; Hirai, Tomohiro; Shigemoto, Yasumasa; Gojobori, Takashi; Sugawara, Hideaki

    2012-09-01

    The Targeted Proteins Research Program (TPRP) promoted by the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan is the phase II of structural biology project (2007-2011) following the Protein 3000 Project (2002-2006) in Japan. While the phase I Protein 3000 Project put partial emphasis on the construction and maintenance of pipelines for structural analyses, the TPRP is dedicated to revealing the structures and functions of the targeted proteins that have great importance in both basic research and industrial applications. To pursue this objective, 35 Targeted Proteins (TP) Projects selected in the three areas of fundamental biology, medicine and pharmacology, and food and environment are tightly collaborated with 10 Advanced Technology (AT) Projects in the four fields of protein production, structural analyses, chemical library and screening, and information platform. Here, the outlines and achievements of the 35 TP Projects are summarized in the system named TP Atlas. Progress in the diversified areas is described in the modules of Graphical Summary, General Summary, Tabular Summary, and Structure Gallery of the TP Atlas in the standard and unified format. Advances in TP Projects owing to novel technologies stemmed from AT Projects and collaborative research among TP Projects are illustrated as a hallmark of the Program. The TP Atlas can be accessed at http://net.genes.nig.ac.jp/tpatlas/index_e.html .

  1. σ and η Phase formation in advanced polycrystalline Ni-base superalloys

    Energy Technology Data Exchange (ETDEWEB)

    Antonov, Stoichko, E-mail: santonov@hawk.iit.edu [Illinois Institute of Technology, 10 W. 32nd Street, Chicago, IL 60616 (United States); Huo, Jiajie; Feng, Qiang [State Key Laboratory for Advanced Metals and Materials, University of Science and Technology Beijing, Beijing 100083 (China); Isheim, Dieter; Seidman, David N. [Department of Materials Science and Engineering, Northwestern University, 2220 Campus Drive, Evanston, IL 60208 (United States); Northwestern University Center for Atom Probe Tomography (NUCAPT), 2220 Campus Drive, Evanston, IL 60208 (United States); Helmink, Randolph C.; Sun, Eugene [Rolls-Royce Corporation, 450 S. Meridian Street, Indianapolis, IN 46225 (United States); Tin, Sammy [Illinois Institute of Technology, 10 W. 32nd Street, Chicago, IL 60616 (United States)

    2017-02-27

    In polycrystalline Ni-base superalloys, grain boundary precipitation of secondary phases can be significant due to the effects they pose on the mechanical properties. As new alloying concepts for polycrystalline Ni-base superalloys are being developed to extend their temperature capability, the effect of increasing levels of Nb alloying additions on long term phase stability and the formation of topologically close packed (TCP) phases needs to be studied. Elevated levels of Nb can result in increased matrix supersaturation and promote the precipitation of secondary phases. Long term thermal exposures on two experimental powder processed Ni-base superalloys containing various levels of Nb were completed to assess the stability and precipitation of TCP phases. It was found that additions of Nb promoted the precipitation of η-Ni{sub 6}AlNb along the grain boundaries in powder processed, polycrystalline Ni-base superalloys, while reduced Nb levels favored the precipitation of blocky Cr and Mo – rich σ phase precipitates along the grain boundary. Evaluation of the thermodynamic stability of these two phases in both alloys using Thermo-calc showed that while σ phase predictions are fairly accurate, predictions of the η phase are limited.

  2. Design and screening of nanoprecipitates-strengthened advanced ferritic alloys

    Energy Technology Data Exchange (ETDEWEB)

    Tan, Lizhen [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Yang, Ying [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Chen, Tianyi [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Sridharan, K. [Univ. of Wisconsin, Madison, WI (United States); He, Li [Univ. of Wisconsin, Madison, WI (United States)

    2016-12-30

    Advanced nuclear reactors as well as the life extension of light water reactors require advanced alloys capable of satisfactory operation up to neutron damage levels approaching 200 displacements per atom (dpa). Extensive studies, including fundamental theories, have demonstrated the superior resistance to radiation-induced swelling in ferritic steels, primarily inherited from their body-centered cubic (bcc) structure. This study aims at developing nanoprecipitates strengthened advanced ferritic alloys for advanced nuclear reactor applications. To be more specific, this study aims at enhancing the amorphization ability of some precipitates, such as Laves phase and other types of intermetallic phases, through smart alloying strategy, and thereby promote the crystalline®amorphous transformation of these precipitates under irradiation.

  3. Measurement of the transfer function of the main SPS Quadrupoles

    CERN Document Server

    Dinius, A; Semanaz, P; CERN. Geneva. SPS and LEP Division

    1998-01-01

    During two short MD's we have measured the transfer function (amplitude and phase) of the main quadrupole string QD. By the word string we mean the global effect of power supplies, magnets and the eddy current effects of the vacuum chamber. This paper presents the measurement procedure and the results, which are needed for the design of a real-time feedback system for the betatron tunes ( Qloop).

  4. Advanced Gas Sensing Technology for Space Suits, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Advanced space suits require lightweight, low-power, durable sensors for monitoring critical life support materials. No current compact sensors have the tolerance...

  5. Engineered Materials for Advanced Gas Turbine Engine, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This project will develop innovative composite powders and composites that will surpass the properties of currently identified materials for advanced gas turbine...

  6. An hour of bright white light in the early morning improves performance and advances sleep and circadian phase during the Antarctic winter.

    Science.gov (United States)

    Corbett, R W; Middleton, B; Arendt, J

    2012-09-13

    Previous work has demonstrated that exposure to an hour of bright light in the morning and the evening during the Polar winter has beneficial effects on circadian phase. This study investigated the effect of a single hour of bright white morning light on circadian phase, sleep, alertness and cognitive performance. Nine individuals (eight male, one female, median age 30 years), wintering at Halley Research Station (75°S), Antarctica from 7th May until 6th August 2007, were exposed to bright white light for a fortnight from 08:30 to 09:30 h, with two fortnight control periods on either side. This sequence was performed twice, before and following Midwinter. Light exposure, sleep and alertness were assessed daily by actigraphy, sleep diaries and subjective visual analogue scales. Circadian phase (assessed by urinary 6-sulphatoxymelatonin rhythm) and cognitive performance were evaluated at the end of each fortnight. During light exposure circadian phase was advanced from 4.97 ± 0.96 decimal hours (dh) (mean ± SD) to 4.08 ± 0.68 dh (p = 0.003). Wake-up time was shifted by a similar margin from 8.45 ± 1.83 dh to 7.59 ± 0.78 dh (p < 0.001). Sleep start time was also advanced (p = 0.047) but by a lesser amount, consequently, actual sleep time was slightly reduced. There was no change in objective or subjective measures of sleep quality or subjective measures of alertness. An improvement in cognitive performance was found with both the Single Letter Cancellation Test (p < 0.001) and the Digit Symbol Substitution Test (p = 0.026) with preserved circadian variation. These beneficial effects of a single short duration light treatment may have implications not only for the Antarctic but other remote environments where access to natural light and delayed circadian phase, is problematic. These results require validation in larger studies at varying locations. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  7. Advanced Stirling Convertor Update

    Science.gov (United States)

    Wood, J. Gary; Carroll, Cliff; Matejczyk, Dan; Penswick, L. B.; Soendker, E.

    2006-01-01

    This paper reports on the 88 We Advanced Stirling Convertor (ASC) currently being developed under Phase II of a NASA NRA program for possible use in advanced high specific power radioisotope space power systems. An early developmental unit, the Frequency Test Bed (FTB) which was built and tested in Phase I demonstrated 36% efficiency. The ASC-1 currently being developed under Phase II, uses a high temperature heater head to allow for operation at 850 °C and is expected to have an efficiency approaching 40% (based on AC electrical out) at a temperature ratio of 3.1. The final lightweight ASC-2 convertor to be developed in Phase III is expected to have a mass of approximately 1 kg. The implementation of the ASC would allow for much higher specific power radioisotope power systems, requiring significantly less radioisotope fuel than current systems. The first run of the ASC-1 occurred in September 2005, and full temperature operation was achieved in early October 2005. Presented is an update on progress on the ASC program as well as the plans for future development. Also presented are efforts being performed to ensure the ASC has the required long life already demonstrated in free-piston Stirling cryocoolers.

  8. Space-charge limits on the transport of ion beams in a long alternating gradient system

    International Nuclear Information System (INIS)

    Tiefenback, M.G.

    1986-11-01

    We have experimentally studied the space-charge-dominated transport of ion beams in an alternating-gradient channel, without acceleration. We parameterize the focusing strength in terms of the zero-current ''betatron'' oscillation phase advance rate, σ 0 (degrees per focusing period). We have investigated the conditions for ''stability'', defined as the constancy of the total current and phase space area of the beam during transport. We find that the beam may be transported with neither loss of current nor growth in phase area if σ 0 0 . In this regime, the space-charge repulsive force can counter 98-99% of the externally applied focusing field, and the oscillation frequency of the beam particles can be depressed by self-forces to almost a factor of 10 below the zero-current value, limited only by the optical quality of our ion source. For σ 0 > 90 0 , we find that collective interactions bound the maintainable density of the beam, and we present a simple, semi-empirical characterization for stability, within our ability to distinguish the growth rate from zero in our apparatus. Our channel comprises 87 quadrupole lenses, 5 of which are used to prepare the beam for injection into the non-azimuthally-symmetric focusing channel

  9. The LHC dynamic aperture

    CERN Document Server

    Koutchouk, Jean-Pierre

    1999-01-01

    In 1996, the expected field errors in the dipoles and quadrupoles yielded a long-term dynamic aperture of some 8sigma at injection. The target was set to 12sigma to account for the limitations of our model (imperfections and dynamics). From scaling laws and tracking, a specification for the field imperfections yielding the target dynamic aperture was deduced. The gap between specification and expected errors is being bridged by i) an improvement of the dipole field quality, ii) a balance between geometric and persistent current errors, iii) additional correction circuits (a3 ,b4 ). With the goal in view, the emphasis has now turned to the sensitivity of the dynamic aperture to the optical parameters.The distortion of the dynamics at the lower amplitudes effectively reached by the particles is minimized by optimizing the distribution of the betatron phase advance. At collision energy, the dynamic aperture is limited by the field imperfections of the low-beta triplets, enhanced by the crossing angle. With corre...

  10. Design Considerations for Proposed Fermilab Integrable RCS

    Energy Technology Data Exchange (ETDEWEB)

    Eldred, Jeffrey [Fermilab; Valishev, Alexander

    2017-03-02

    Integrable optics is an innovation in particle accelerator design that provides strong nonlinear focusing while avoiding parametric resonances. One promising application of integrable optics is to overcome the traditional limits on accelerator intensity imposed by betatron tune-spread and collective instabilities. The efficacy of high-intensity integrable accelerators will be undergo comprehensive testing over the next several years at the Fermilab Integrable Optics Test Accelerator (IOTA) and the University of Maryland Electron Ring (UMER). We propose an integrable Rapid-Cycling Synchrotron (iRCS) as a replacement for the Fermilab Booster to achieve multi-MW beam power for the Fermilab high-energy neutrino program. We provide a overview of the machine parameters and discuss an approach to lattice optimization. Integrable optics requires arcs with integer-pi phase advance followed by drifts with matched beta functions. We provide an example integrable lattice with features of a modern RCS - long dispersion-free drifts, low momentum compaction, superperiodicity, chromaticity correction, separate-function magnets, and bounded beta functions.

  11. Low emittance configuration for spear

    International Nuclear Information System (INIS)

    Blumberg, L.N.; Harris, J.; Stege, R.; Cerino, J.; Hettel, R.; Hofmann, A.; Liu, R.Z.; Wiedemann, H.; Winick, H.

    1985-01-01

    The quality of synchrotron radiation beams from SPEAR, in particular the brilliance of undulator radiation, can be improved significantly by reducing the emittance of the stored electron beam. A reduction of the horizontal emittance by a factor of 3.5 to a value of 130 nanometer-radians (nm-r) at 3 GeV has been achieved by using stronger focussing, mainly in the horizontal plane. The low emittance configuration also reduces the dispersion and vertical beta functions in the straight sections, making them more suitable for wigglers. The higher betatron tunes lead to a larger phase advance between the two kickers, which has to be corrected during injection by shunting current from some quadrupoles. The configuration was optimized within SPEAR hardware limitations and tested for dynamic aperture with the tracking program PATRICIA. After implementation of this scheme, beam was successfully injected and accumulated. The measured emittance of the stored beam was in agreement with calculations. Presently the configuration is being made operational

  12. A low emittance configuration for spear

    International Nuclear Information System (INIS)

    Blumberg, L.N.; Cerino, J.; Harris, J.; Hettel, R.; Hofmann, A.; Liu, R.Z.; Stego, R.; Wiedemann, H.; Winick, H.

    1985-01-01

    The quality of synchrotron radiation beams from SPEAR, in particular the brilliance of undulator radiation, can be improved significantly by reducing the emittance of the stored electron beam. A reduction of the horizontal emittance by a factor of 3.5 to a value of 130 nanometer-radians (nm-r) at 3 GeV has been achieved by using stronger focussing, mainly in the horizontal plane. The low emittance configuration also reduces the dispersion and vertical beta functions in the straight sections, making them more suitable for wigglers. The higher betatron tunes lead to a larger phase advance between the two kickers, which has to be corrected during injection by shunting current from some quadrupoles. The configuration was optimized within SPEAR hardware limitations and tested for dynamic aperture with the tracking program PATRICIA. After implementation of this scheme, beam was successfully injected and accumulated. The measured emittance of the stored beam was in agreement with calculations. Presently the configuration is being made operational

  13. Loss concentration and evacuation by mini-wire-septa from circular machines for spallation neutron sources

    CERN Document Server

    Schönauer, Horst Otto

    1996-01-01

    Efficient loss management is crucial in high-intensity circular machines like neutron sources, and those using superconducting magnets. Collimator systems have been designed or are under intensive study [1]. The common problem of collimation is the outscattering from the collimator faces which are most frequently hit at shallow depth. In this situation high collection efficiency can only be achieved by two-or-more-stage, double-jaw, systems requiring betatron phase advances approaching 2p. As the outscattering is isotropic, both transverse planes are affected and the system layout becomes a two-dimensional problem. Any convincing single-stage collimation system would be simpler to operate and is likely to be less expensive. The possible physical evacuation of the lost beam towards a remote dump can drastically reduce the radioactivity level in the tunnel. Moreover, fitting a two-stage system into an existing machine is difficult and in general not very promising. In this situation a wire septum may be the onl...

  14. Heavy ion fusion year-end report, April 1, 1983-September 30, 1983

    International Nuclear Information System (INIS)

    1983-11-01

    Some highlights of the program during this reporting period are as follows: (1) First results with the completed apparatus of the Single Beam Transport Experiment (SBTE) have shown the stable propagation of a space-charge-dominated cesium-ion beam through 41 periods of an AG focussing lattice. The space-charge effects were large enough to depress the betatron phase advance per cell from sigma 0 = 60 0 to sigma = 12 0 . (2) Understanding of the reflection stabilization of longitudinal instability in a high-current beam bunch has been improved by analytical and computational studies. (3) Conceptual design studies of a multiple-beam ion induction linac suitable for the High Temperature Experiment have progressed to the stage where a first reference design (sodium, 125 MeV, 30 μC, 16 beams) is available. (4) The Long-Pulse Induction Accelerating Unit, first used to accelerate a cesium-ion beam in February 1983, has been undergoing modification in the low-level trigger circuitry to allow more precisely controlled waveform synthesis

  15. Phase III Randomized Clinical Trial Comparing Tremelimumab With Standard-of-Care Chemotherapy in Patients With Advanced Melanoma

    Science.gov (United States)

    Ribas, Antoni; Kefford, Richard; Marshall, Margaret A.; Punt, Cornelis J.A.; Haanen, John B.; Marmol, Maribel; Garbe, Claus; Gogas, Helen; Schachter, Jacob; Linette, Gerald; Lorigan, Paul; Kendra, Kari L.; Maio, Michele; Trefzer, Uwe; Smylie, Michael; McArthur, Grant A.; Dreno, Brigitte; Nathan, Paul D.; Mackiewicz, Jacek; Kirkwood, John M.; Gomez-Navarro, Jesus; Huang, Bo; Pavlov, Dmitri; Hauschild, Axel

    2013-01-01

    Purpose In phase I/II trials, the cytotoxic T lymphocyte–associated antigen-4–blocking monoclonal antibody tremelimumab induced durable responses in a subset of patients with advanced melanoma. This phase III study evaluated overall survival (OS) and other safety and efficacy end points in patients with advanced melanoma treated with tremelimumab or standard-of-care chemotherapy. Patients and Methods Patients with treatment-naive, unresectable stage IIIc or IV melanoma were randomly assigned at a ratio of one to one to tremelimumab (15 mg/kg once every 90 days) or physician's choice of standard-of-care chemotherapy (temozolomide or dacarbazine). Results In all, 655 patients were enrolled and randomly assigned. The test statistic crossed the prespecified futility boundary at second interim analysis after 340 deaths, but survival follow-up continued. At final analysis with 534 events, median OS by intent to treat was 12.6 months (95% CI, 10.8 to 14.3) for tremelimumab and 10.7 months (95% CI, 9.36 to 11.96) for chemotherapy (hazard ratio, 0.88; P = .127). Objective response rates were similar in the two arms: 10.7% in the tremelimumab arm and 9.8% in the chemotherapy arm. However, response duration (measured from date of random assignment) was significantly longer after tremelimumab (35.8 v 13.7 months; P = .0011). Diarrhea, pruritus, and rash were the most common treatment-related adverse events in the tremelimumab arm; 7.4% had endocrine toxicities. Seven deaths in the tremelimumab arm and one in the chemotherapy arm were considered treatment related by either investigators or sponsor. Conclusion This study failed to demonstrate a statistically significant survival advantage of treatment with tremelimumab over standard-of-care chemotherapy in first-line treatment of patients with metastatic melanoma. PMID:23295794

  16. Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma.

    Science.gov (United States)

    Ribas, Antoni; Kefford, Richard; Marshall, Margaret A; Punt, Cornelis J A; Haanen, John B; Marmol, Maribel; Garbe, Claus; Gogas, Helen; Schachter, Jacob; Linette, Gerald; Lorigan, Paul; Kendra, Kari L; Maio, Michele; Trefzer, Uwe; Smylie, Michael; McArthur, Grant A; Dreno, Brigitte; Nathan, Paul D; Mackiewicz, Jacek; Kirkwood, John M; Gomez-Navarro, Jesus; Huang, Bo; Pavlov, Dmitri; Hauschild, Axel

    2013-02-10

    In phase I/II trials, the cytotoxic T lymphocyte-associated antigen-4-blocking monoclonal antibody tremelimumab induced durable responses in a subset of patients with advanced melanoma. This phase III study evaluated overall survival (OS) and other safety and efficacy end points in patients with advanced melanoma treated with tremelimumab or standard-of-care chemotherapy. Patients with treatment-naive, unresectable stage IIIc or IV melanoma were randomly assigned at a ratio of one to one to tremelimumab (15 mg/kg once every 90 days) or physician's choice of standard-of-care chemotherapy (temozolomide or dacarbazine). In all, 655 patients were enrolled and randomly assigned. The test statistic crossed the prespecified futility boundary at second interim analysis after 340 deaths, but survival follow-up continued. At final analysis with 534 events, median OS by intent to treat was 12.6 months (95% CI, 10.8 to 14.3) for tremelimumab and 10.7 months (95% CI, 9.36 to 11.96) for chemotherapy (hazard ratio, 0.88; P = .127). Objective response rates were similar in the two arms: 10.7% in the tremelimumab arm and 9.8% in the chemotherapy arm. However, response duration (measured from date of random assignment) was significantly longer after tremelimumab (35.8 v 13.7 months; P = .0011). Diarrhea, pruritus, and rash were the most common treatment-related adverse events in the tremelimumab arm; 7.4% had endocrine toxicities. Seven deaths in the tremelimumab arm and one in the chemotherapy arm were considered treatment related by either investigators or sponsor. This study failed to demonstrate a statistically significant survival advantage of treatment with tremelimumab over standard-of-care chemotherapy in first-line treatment of patients with metastatic melanoma.

  17. High Performance Thrusters for Advanced Green Monopropellants, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — The development of an advanced green monopropellant propulsion system could have significant benefits to a wide range of NASA space missions, from deep space...

  18. Modular Advanced Networked Telerobotic Interface System (MANTIS), Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — With the goal to reduce astronaut time required to operate experiments on the ISS and advance automated and telerobotic technology, TUI proposes to collaborate with...

  19. Advanced Exploration Systems Water Architecture Study Interim Results

    Science.gov (United States)

    Sargusingh, Miriam J.

    2013-01-01

    The mission of the Advanced Exploration System (AES) Water Recovery Project (WRP) is to develop advanced water recovery systems that enable NASA human exploration missions beyond low Earth orbit (LEO). The primary objective of the AES WRP is to develop water recovery technologies critical to near-term missions beyond LEO. The secondary objective is to continue to advance mid-readiness-level technologies to support future NASA missions. An effort is being undertaken to establish the architecture for the AES Water Recovery System (WRS) that meets both near- and long-term objectives. The resultant architecture will be used to guide future technical planning, establish a baseline development roadmap for technology infusion, and establish baseline assumptions for integrated ground and on-orbit Environmental Control and Life Support Systems definition. This study is being performed in three phases. Phase I established the scope of the study through definition of the mission requirements and constraints, as well as identifying all possible WRS configurations that meet the mission requirements. Phase II focused on the near-term space exploration objectives by establishing an International Space Station-derived reference schematic for long-duration (>180 day) in-space habitation. Phase III will focus on the long-term space exploration objectives, trading the viable WRS configurations identified in Phase I to identify the ideal exploration WRS. The results of Phases I and II are discussed in this paper.

  20. C18, C8, and perfluoro reversed phases on diamond for solid-phase extraction.

    Science.gov (United States)

    Saini, Gaurav; Wiest, Landon A; Herbert, David; Biggs, Katherine N; Dadson, Andrew; Vail, Michael A; Linford, Matthew R

    2009-04-17

    In spite of advances in solid-phase extraction (SPE) technology there are certain disadvantages to current SPE silica-based, column packings. The pH range over which extraction can occur is limited and each column is generally only used once. New diamond-based reversed SPE phases (C(18), C(8), and perfluorinated) were developed in our laboratories. Studies were done which show that these phases do not have the same limitations as traditional silica-based stationary phases. The synthesis and properties of these diamond-based phases are presented, and the stability, percent recovery, and column capacity are given for the C(18) phase.

  1. Modeling of liquid phases

    CERN Document Server

    Soustelle, Michel

    2015-01-01

    This book is part of a set of books which offers advanced students successive characterization tool phases, the study of all types of phase (liquid, gas and solid, pure or multi-component), process engineering, chemical and electrochemical equilibria, and the properties of surfaces and phases of small sizes. Macroscopic and microscopic models are in turn covered with a constant correlation between the two scales. Particular attention has been given to the rigor of mathematical developments. This second volume in the set is devoted to the study of liquid phases.

  2. Advanced Onboard Energy Storage Solution for Balloons, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Advanced Balloon Programs at NASA are looking for a potential 100 day missions at mid-altitudes. These balloons would be powered by solar panels to take advantage of...

  3. Phase II study. Concurrent chemotherapy and radiotherapy with nitroglycerin in locally advanced non-small cell lung cancer

    International Nuclear Information System (INIS)

    Arrieta, Oscar; Blake, Mónika; Mata-Moya, María Dolores de la; Corona, Francisco; Turcott, Jenny; Orta, David; Alexander-Alatorre, Jorge; Gallardo-Rincón, Dolores

    2014-01-01

    Background: Nitroglycerin, a nitric oxide donor agent, reduces the expression of hypoxia-inducible factor-1α (HIF-1α) and could be a normalizer of the tumor microenvironment. Both factors are associated with chemo-radio-resistance. The aim of this study was to determine the safety profile and efficacy of nitroglycerin administration with chemo-radiotherapy in patients with locally advanced non-small cell lung cancer (NSCLC). Methods: This is a phase II trial of locally advanced NSCLC patients treated with cisplatin and vinorelbine plus concurrent nitroglycerin with radiotherapy. A 25-mg NTG patch was administered to the patients for 5 days (1 day before and 4 days after chemotherapy induction and consolidation) and all day during chemo-radiotherapy. VEGF plasmatic level was determined before and after two cycles of chemotherapy. Results: Thirty-five patients were enrolled in this trial. Sixty-three percent of patients achieved an overall response after induction of chemotherapy, and 75% achieved an overall response after chemo-radiotherapy. The median progression-free survival was 13.5 months (95% CI, 8.8–18.2), and the median overall survival was 26.9 months (95% CI, 15.3–38.5). Reduction of VEGF level was associated with better OS. The toxicity profile related to nitroglycerin included headache (20%) and hypotension (2.9%). Conclusions: The addition of nitroglycerin to induction chemotherapy and concurrent chemoradiotherapy in patients with locally advanced NSCLC has an acceptable toxicity profile and supports the possibility to add nitroglycerin to chemotherapy and radiotherapy. A randomized trial is warranted to confirm these findings

  4. Advanced Simulation Capability for Environmental Management - Current Status and Phase II Demonstration Results - 13161

    Energy Technology Data Exchange (ETDEWEB)

    Seitz, Roger R.; Flach, Greg [Savannah River National Laboratory, Savannah River Site, Bldg 773-43A, Aiken, SC 29808 (United States); Freshley, Mark D.; Freedman, Vicky; Gorton, Ian [Pacific Northwest National Laboratory, MSIN K9-33, P.O. Box 999, Richland, WA 99352 (United States); Dixon, Paul; Moulton, J. David [Los Alamos National Laboratory, MS B284, P.O. Box 1663, Los Alamos, NM 87544 (United States); Hubbard, Susan S.; Faybishenko, Boris; Steefel, Carl I.; Finsterle, Stefan [Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS 50B-4230, Berkeley, CA 94720 (United States); Marble, Justin [Department of Energy, 19901 Germantown Road, Germantown, MD 20874-1290 (United States)

    2013-07-01

    The U.S. Department of Energy (US DOE) Office of Environmental Management (EM), Office of Soil and Groundwater, is supporting development of the Advanced Simulation Capability for Environmental Management (ASCEM). ASCEM is a state-of-the-art scientific tool and approach for understanding and predicting contaminant fate and transport in natural and engineered systems. The modular and open source high-performance computing tool facilitates integrated approaches to modeling and site characterization that enable robust and standardized assessments of performance and risk for EM cleanup and closure activities. The ASCEM project continues to make significant progress in development of computer software capabilities with an emphasis on integration of capabilities in FY12. Capability development is occurring for both the Platform and Integrated Tool-sets and High-Performance Computing (HPC) Multi-process Simulator. The Platform capabilities provide the user interface and tools for end-to-end model development, starting with definition of the conceptual model, management of data for model input, model calibration and uncertainty analysis, and processing of model output, including visualization. The HPC capabilities target increased functionality of process model representations, tool-sets for interaction with Platform, and verification and model confidence testing. The Platform and HPC capabilities are being tested and evaluated for EM applications in a set of demonstrations as part of Site Applications Thrust Area activities. The Phase I demonstration focusing on individual capabilities of the initial tool-sets was completed in 2010. The Phase II demonstration completed in 2012 focused on showcasing integrated ASCEM capabilities. For Phase II, the Hanford Site deep vadose zone (BC Cribs) served as an application site for an end-to-end demonstration of capabilities, with emphasis on integration and linkages between the Platform and HPC components. Other demonstrations

  5. Advanced Simulation Capability for Environmental Management - Current Status and Phase II Demonstration Results - 13161

    International Nuclear Information System (INIS)

    Seitz, Roger R.; Flach, Greg; Freshley, Mark D.; Freedman, Vicky; Gorton, Ian; Dixon, Paul; Moulton, J. David; Hubbard, Susan S.; Faybishenko, Boris; Steefel, Carl I.; Finsterle, Stefan; Marble, Justin

    2013-01-01

    The U.S. Department of Energy (US DOE) Office of Environmental Management (EM), Office of Soil and Groundwater, is supporting development of the Advanced Simulation Capability for Environmental Management (ASCEM). ASCEM is a state-of-the-art scientific tool and approach for understanding and predicting contaminant fate and transport in natural and engineered systems. The modular and open source high-performance computing tool facilitates integrated approaches to modeling and site characterization that enable robust and standardized assessments of performance and risk for EM cleanup and closure activities. The ASCEM project continues to make significant progress in development of computer software capabilities with an emphasis on integration of capabilities in FY12. Capability development is occurring for both the Platform and Integrated Tool-sets and High-Performance Computing (HPC) Multi-process Simulator. The Platform capabilities provide the user interface and tools for end-to-end model development, starting with definition of the conceptual model, management of data for model input, model calibration and uncertainty analysis, and processing of model output, including visualization. The HPC capabilities target increased functionality of process model representations, tool-sets for interaction with Platform, and verification and model confidence testing. The Platform and HPC capabilities are being tested and evaluated for EM applications in a set of demonstrations as part of Site Applications Thrust Area activities. The Phase I demonstration focusing on individual capabilities of the initial tool-sets was completed in 2010. The Phase II demonstration completed in 2012 focused on showcasing integrated ASCEM capabilities. For Phase II, the Hanford Site deep vadose zone (BC Cribs) served as an application site for an end-to-end demonstration of capabilities, with emphasis on integration and linkages between the Platform and HPC components. Other demonstrations

  6. Automated Deployment of Advanced Controls and Analytics in Buildings

    Science.gov (United States)

    Pritoni, Marco

    Buildings use 40% of primary energy in the US. Recent studies show that developing energy analytics and enhancing control strategies can significantly improve their energy performance. However, the deployment of advanced control software applications has been mostly limited to academic studies. Larger-scale implementations are prevented by the significant engineering time and customization required, due to significant differences among buildings. This study demonstrates how physics-inspired data-driven models can be used to develop portable analytics and control applications for buildings. Specifically, I demonstrate application of these models in all phases of the deployment of advanced controls and analytics in buildings: in the first phase, "Site Preparation and Interface with Legacy Systems" I used models to discover or map relationships among building components, automatically gathering metadata (information about data points) necessary to run the applications. During the second phase: "Application Deployment and Commissioning", models automatically learn system parameters, used for advanced controls and analytics. In the third phase: "Continuous Monitoring and Verification" I utilized models to automatically measure the energy performance of a building that has implemented advanced control strategies. In the conclusions, I discuss future challenges and suggest potential strategies for these innovative control systems to be widely deployed in the market. This dissertation provides useful new tools in terms of procedures, algorithms, and models to facilitate the automation of deployment of advanced controls and analytics and accelerate their wide adoption in buildings.

  7. In vitro testing of drug combinations employing nilotinib and alkylating agents with regard to pretransplant conditioning treatment of advanced-phase chronic myeloid leukemia.

    Science.gov (United States)

    Radujkovic, Aleksandar; Luft, Thomas; Dreger, Peter; Ho, Anthony D; Jens Zeller, W; Fruehauf, Stefan; Topaly, Julian

    2014-08-01

    The prognosis of patients with advanced-phase chronic myeloid leukemia (CML) remains dismal despite the availability of targeted therapies and allogeneic stem cell transplantation (allo-SCT). Increasing the antileukemic efficacy of the pretransplant conditioning regimen may be a strategy to increase remission rates and duration. We therefore investigated the antiproliferative effects of nilotinib in combination with drugs that are usually used for conditioning: the alkylating agents mafosfamide, treosulfan, and busulfan. Drug combinations were tested in vitro in different imatinib-sensitive and imatinib-resistant BCR-ABL-positive cell lines. A tetrazolium-based MTT assay was used for the assessment and quantification of growth inhibition after exposure to alkylating agents alone or to combinations with nilotinib. Drug interaction was analyzed using the median-effect method of Chou and Talalay, and combination index (CI) values were calculated according to the classic isobologram equation. Treatment of imatinib-sensitive, BCR-ABL-positive K562 and LAMA84 cells with nilotinib in combination with mafosfamide, treosulfan, or busulfan resulted in synergistic (CI 1) effects, respectively. In imatinib-resistant K562-R and LAMA84-R cells, all applied drug combinations were synergistic (CI conditioning regimens for allo-SCT in advanced-phase CML.

  8. Application of advanced statistical methods in assessment of the late phase of a nuclear accident

    International Nuclear Information System (INIS)

    Hofman, R.

    2008-01-01

    The paper presents a new methodology for improving of estimates of radiological situation on terrain in the late phase of a nuclear accident. Methods of Bayesian filtering are applied to the problem. The estimates are based on combination of modeled and measured data provided by responsible authorities. Exploiting information on uncertainty of both the data sources, we are able to produce improved estimate of the true situation on terrain. We also attempt to account for model error, which is unknown and plays crucial role in accuracy of the estimates. The main contribution of this paper is application of an approach based on advanced statistical methods, which allows for estimating of model error covariance structure upon measurements. Model error is estimated on basis of measured-minus-observed residuals evaluated upon measured and modeled values. The methodology is demonstrated on a sample scenario with simulated measurements. (authors)

  9. Application of advanced statistical methods in assessment of the late phase of a nuclear accident

    International Nuclear Information System (INIS)

    Hofman, R.

    2009-01-01

    The paper presents a new methodology for improving of estimates of radiological situation on terrain in the late phase of a nuclear accident. Methods of Bayesian filtering are applied to the problem. The estimates are based on combination of modeled and measured data provided by responsible authorities. Exploiting information on uncertainty of both the data sources, we are able to produce improved estimate of the true situation on terrain. We also attempt to account for model error, which is unknown and plays crucial role in accuracy of the estimates. The main contribution of this paper is application of an approach based on advanced statistical methods, which allows for estimating of model error covariance structure upon measurements. Model error is estimated on basis of measured-minus-observed residuals evaluated upon measured and modeled values. The methodology is demonstrated on a sample scenario with simulated measurements. (authors)

  10. Advanced Filtering Techniques Applied to Spaceflight, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — IST-Rolla developed two nonlinear filters for spacecraft orbit determination during the Phase I contract. The theta-D filter and the cost based filter, CBF, were...

  11. Overview of Phase Space Manipulations of Relativistic Electron Beams

    Energy Technology Data Exchange (ETDEWEB)

    Xiang, Dao; /SLAC

    2012-08-31

    Phase space manipulation is a process to rearrange beam's distribution in 6-D phase space. In this paper, we give an overview of the techniques for tailoring beam distribution in 2D, 4D, and 6D phase space to meet the requirements of various applications. These techniques become a new focus of accelerator physics R&D and very likely these advanced concepts will open up new opportunities in advanced accelerators and the science enabled by them.

  12. Overview of Phase Space Manipulations of Relativistic Electron Beams

    International Nuclear Information System (INIS)

    Xiang, Dao

    2012-01-01

    Phase space manipulation is a process to rearrange beam's distribution in 6-D phase space. In this paper, we give an overview of the techniques for tailoring beam distribution in 2D, 4D, and 6D phase space to meet the requirements of various applications. These techniques become a new focus of accelerator physics R and D and very likely these advanced concepts will open up new opportunities in advanced accelerators and the science enabled by them.

  13. First test of high frequency Gravity Waves from inflation using Advanced LIGO

    International Nuclear Information System (INIS)

    Lopez, Alejandro; Freese, Katherine

    2015-01-01

    Inflation models ending in a first order phase transition produce gravitational waves (GW) via bubble collisions of the true vacuum phase. We demonstrate that these bubble collisions can leave an observable signature in Advanced LIGO, an upcoming ground-based GW experiment. These GW are dependent on two parameters of the inflationary model: ε represents the energy difference between the false vacuum and the true vacuum of the inflaton potential, and χ measures how fast the phase transition ends (χ ∼ the number of e-folds during the actual phase transition). Advanced LIGO will be able to test the validity of single-phase transition models within the parameter space 10 7  GeV∼< ε 1/4  ∼< 10 10  GeV and 0.19 ∼< χ ∼< 1. If inflation occurred through a first order phase transition, then Advanced LIGO could be the first to discover high frequency GW from inflation

  14. Phase Contrast Imaging

    International Nuclear Information System (INIS)

    Menk, Ralf Hendrik

    2008-01-01

    All standard (medical) x-ray imaging technologies, rely primarily on the amplitude properties of the incident radiation, and do not depend on its phase. This is unchanged since the discovery by Roentgen that the intensity of an x-ray beam, as measured by the exposure on a film, was related to the relative transmission properties of an object. However, recently various imaging techniques have emerged which depend on the phase of the x-rays as well as the amplitude. Phase becomes important when the beam is coherent and the imaging system is sensitive to interference phenomena. Significant new advances have been made in coherent optic theory and techniques, which now promise phase information in medical imaging. The development of perfect crystal optics and the increasing availability of synchrotron radiation facilities have contributed to a significant increase in the application of phase based imaging in materials and life sciences. Unique source characteristics such as high intensity, monochromaticity, coherence and high collimating provide an ideal source for advanced imaging. Phase contrast imaging has been applied in both projection and computed tomography modes, and recent applications have been made in the field of medical imaging. Due to the underlying principle of X-ray detection conventional image receptors register only intensities of wave fields and not their phases. During the last decade basically five different methods were developed that translate the phase information into intensity variations. These methods are based on measuring the phase shift φ directly (using interference phenomena), the gradient ∇ φ , or the Laplacian ∇ 2 φ. All three methods can be applied to polychromatic X-ray sources keeping in mind that the native source is synchrotron radiation, featuring monochromatic and reasonable coherent X-ray beams. Due to the vast difference in the coefficients that are driven absorption and phase effects (factor 1,000-10,000 in the energy

  15. A simple way to characterize linear coupling in a storage ring

    International Nuclear Information System (INIS)

    Wolski, Andrzej

    2004-01-01

    The techniques of normal form analysis, well known in the literature, can be used to provide a straightforward characterization of linear betatron dynamics in a coupled lattice. Here, we consider both the beam distribution and the betatron oscillations in a storage ring, assuming that the beam emittances and betatron actions respectively are provided as parameters. We find that the beta functions for uncoupled motion generalize in a simple way to the coupled case. Defined in the way that we propose, the beta functions remain well behaved (positive and finite) under all circumstances, and have essentially the same physical significance for the beam size and betatron oscillations as in the uncoupled case. We discuss a technique for making direct measurements of the ratio of the coupled lattice functions at different points in the lattice

  16. Recent advances in two-phase flow numerics

    Energy Technology Data Exchange (ETDEWEB)

    Mahaffy, J.H.; Macian, R. [Pennsylvania State Univ., University Park, PA (United States)

    1997-07-01

    The authors review three topics in the broad field of numerical methods that may be of interest to individuals modeling two-phase flow in nuclear power plants. The first topic is iterative solution of linear equations created during the solution of finite volume equations. The second is numerical tracking of macroscopic liquid interfaces. The final area surveyed is the use of higher spatial difference techniques.

  17. Recent advances in two-phase flow numerics

    International Nuclear Information System (INIS)

    Mahaffy, J.H.; Macian, R.

    1997-01-01

    The authors review three topics in the broad field of numerical methods that may be of interest to individuals modeling two-phase flow in nuclear power plants. The first topic is iterative solution of linear equations created during the solution of finite volume equations. The second is numerical tracking of macroscopic liquid interfaces. The final area surveyed is the use of higher spatial difference techniques

  18. Preliminary results for avelumab plus axitinib as first-line therapy in patients with advanced clear-cell renal-cell carcinoma (JAVELIN Renal 100): an open-label, dose-finding and dose-expansion, phase 1b trial.

    Science.gov (United States)

    Choueiri, Toni K; Larkin, James; Oya, Mototsugu; Thistlethwaite, Fiona; Martignoni, Marcella; Nathan, Paul; Powles, Thomas; McDermott, David; Robbins, Paul B; Chism, David D; Cho, Daniel; Atkins, Michael B; Gordon, Michael S; Gupta, Sumati; Uemura, Hirotsugu; Tomita, Yoshihiko; Compagnoni, Anna; Fowst, Camilla; di Pietro, Alessandra; Rini, Brian I

    2018-04-01

    The combination of an immune checkpoint inhibitor and a VEGF pathway inhibitor to treat patients with advanced renal-cell carcinoma might increase the clinical benefit of these drugs compared with their use alone. Here, we report preliminary results for the combination of avelumab, an IgG1 monoclonal antibody against the programmed cell death protein ligand PD-L1, and axitinib, a VEGF receptor inhibitor approved for second-line treatment of advanced renal-cell carcinoma, in treatment-naive patients with advanced renal-cell carcinoma. The JAVELIN Renal 100 study is an ongoing open-label, multicentre, dose-finding, and dose-expansion, phase 1b study, done in 14 centres in the USA, UK, and Japan. Eligible patients were aged 18 years or older (≥20 years in Japan) and had histologically or cytologically confirmed advanced renal-cell carcinoma with clear-cell component, life expectancy of at least 3 months, an Eastern Cooperative Oncology Group performance status of 1 or less, received no previous systemic treatment for advanced renal cell carcinoma, and had a resected primary tumour. Patients enrolled into the dose-finding phase received 5 mg axitinib orally twice daily for 7 days, followed by combination therapy with 10 mg/kg avelumab intravenously every 2 weeks and 5 mg axitinib orally twice daily. Based on the pharmacokinetic data from the dose-finding phase, ten additional patients were enrolled into the dose-expansion phase and assigned to this regimen. The other patients in the dose-expansion phase started taking combination therapy directly. The primary endpoint was dose-limiting toxicities in the first 4 weeks (two cycles) of treatment with avelumab plus axitinib. Safety and antitumour activity analyses were done in all patients who received at least one dose of avelumab or axitinib. This trial is registered with ClinicalTrials.gov, number NCT02493751. Between Oct 30, 2015, and Sept 30, 2016, we enrolled six patients into the dose-finding phase and 49 into the

  19. HATT: a phase IV, single-arm, open-label study of sorafenib in Taiwanese patients with advanced hepatocellular carcinoma.

    Science.gov (United States)

    Lin, Shi-Ming; Lu, Sheng-Nan; Chen, Ping-Tsung; Jeng, Long-Bin; Chen, Shinn-Cherng; Hu, Chi-Tan; Yang, Sien-Sing; Le Berre, Marie-Aude; Liu, Xuan; Mitchell, David Y; Prins, Klaas; Grevel, Joachim; Peña, Carol A E; Meinhardt, Gerold

    2017-03-01

    Sorafenib significantly improves survival in patients with advanced hepatocellular carcinoma (HCC). This phase IV study assessed sorafenib efficacy/safety in Taiwanese patients with advanced HCC and Child-Pugh A status. All patients received 400 mg sorafenib BID. Safety, efficacy, sorafenib pharmacokinetics, and Child-Pugh progression were evaluated. A hand-foot skin reaction (HFSR) prevention substudy assessed HFSR incidence and grade/severity and time to HFSR in 29 and 34 patients randomized to corticosteroid and noncorticosteroid ointments, respectively, and in 88 nonrandomized patients. The 151 patients included 120 (80%) male patients and 81 (54%) with stage IV disease. Mean sorafenib dose was 626 mg/day, and median treatment duration was 4.2 months. Median overall survival (OS), progression-free survival, and time to progression (TTP) were 8.6, 2.7, and 3.8 months, respectively. Disease control and response rates (partial responses only) were 48 and 6.6%, respectively. Median TTP from Child-Pugh A to B/C was 88 days. Drug-related adverse events (AEs) occurred in 89.4% of patients; none were new or unexpected. The most frequent grade ≥3 drug-related, treatment-emergent AEs were HFSR (13.2%), diarrhea (11.9%), and hypertension (6.6%). Corticosteroid ointment tended to reduce the severity and incidence of all HFSR-associated parameters. Pharmacokinetic exposure was unaltered by Child-Pugh progression. The final pharmacokinetic model predicted 13.1 and 33.8% reductions in sorafenib exposure over 6 and 12 months, respectively. There was a trend of longer OS and TTP in Taiwanese patients with advanced HCC compared with patients with advanced HCC in the Asia-Pacific trial. Sorafenib exposure did not correlate with liver function. Reduced pharmacokinetic exposure over time was unrelated to reduced or interrupted dosing.

  20. Observation and analysis of oscillations in linear accelerators

    International Nuclear Information System (INIS)

    Seeman, J.T.

    1991-11-01

    This report discusses the following on oscillation in linear accelerators: Betatron Oscillations; Betatron Oscillations at High Currents; Transverse Profile Oscillations; Transverse Profile Oscillations at High Currents.; Oscillation and Profile Transient Jitter; and Feedback on Transverse Oscillations

  1. Phase I dose-finding study of sorafenib with FOLFOX4 as first-line treatment in patients with unresectable locally advanced or metastatic gastric cancer.

    Science.gov (United States)

    Chi, Yihebali; Yang, Jianliang; Yang, Sheng; Sun, Yongkun; Jia, Bo; Shi, Yuankai

    2015-06-01

    To determine the maximum tolerated dose (MTD), dose-limiting toxicity (DLT) and efficacy of sorafenib in combination with FOLFOX4 (oxaliplatin/leucovorin (LV)/5-fluorouracil) as first-line treatment for advanced gastric cancer, we performed a phase I dose-finding study in nine evaluable patients with unresectable locally advanced or metastatic gastric cancer or gastroesophageal junction adenocarcinoma. According to modified Fibonacci method, the design of this study was to guide elevation of the sorafenib dosage to the next level (from 200 mg twice daily to 400 mg twice daily and then, if tolerated, 600 mg twice daily). If the patient achieved complete response (CR), partial response (PR) or stable disease (SD) after eight cycles of treatment, combination chemotherapy was scheduled to be discontinued and sorafenib monotherapy continued at the original dose until either disease progression or unacceptable toxicity. In sorafenib 200 mg twice daily group, DLT was observed in 1 of 6 patients, and in 400 mg twice daily group, it was observed in 2 of 3 patients. Seven of 9 (77.8%) evaluable patients achieved PR, with a median overall survival (OS) of 11.8 [95% confidence interval (CI): 8.9-14.7] months. Common adverse effects include hand-foot syndrome, leukopenia, neutropenia, anorexia, and nausea. Twice-daily dosing of sorafenib 200 mg in combination with FOLFOX4 was proven effective and safe for the treatment of advanced gastric cancer, and could be an appropriate dosage for subsequent phase II clinical studies.

  2. An Open-Label, Multicenter, Randomized, Phase II Study of Pazopanib in Combination with Pemetrexed in First-Line Treatment of Patients with Advanced-Stage Non-Small-Cell Lung Cancer

    DEFF Research Database (Denmark)

    Scagliotti, Giorgio V; Felip, Enriqueta; Besse, Benjamin

    2013-01-01

    This randomized open-label phase II study evaluated the efficacy, safety, and tolerability of pazopanib in combination with pemetrexed compared with the standard cisplatin/pemetrexed doublet in patients with previously untreated, advanced, nonsquamous non-small-cell lung cancer....

  3. Advancing Material Models for Automotive Forming Simulations

    International Nuclear Information System (INIS)

    Vegter, H.; An, Y.; Horn, C.H.L.J. ten; Atzema, E.H.; Roelofsen, M.E.

    2005-01-01

    Simulations in automotive industry need more advanced material models to achieve highly reliable forming and springback predictions. Conventional material models implemented in the FEM-simulation models are not capable to describe the plastic material behaviour during monotonic strain paths with sufficient accuracy. Recently, ESI and Corus co-operate on the implementation of an advanced material model in the FEM-code PAMSTAMP 2G. This applies to the strain hardening model, the influence of strain rate, and the description of the yield locus in these models. A subsequent challenge is the description of the material after a change of strain path.The use of advanced high strength steels in the automotive industry requires a description of plastic material behaviour of multiphase steels. The simplest variant is dual phase steel consisting of a ferritic and a martensitic phase. Multiphase materials also contain a bainitic phase in addition to the ferritic and martensitic phase. More physical descriptions of strain hardening than simple fitted Ludwik/Nadai curves are necessary.Methods to predict plastic behaviour of single-phase materials use a simple dislocation interaction model based on the formed cells structures only. At Corus, a new method is proposed to predict plastic behaviour of multiphase materials have to take hard phases into account, which deform less easily. The resulting deformation gradients create geometrically necessary dislocations. Additional micro-structural information such as morphology and size of hard phase particles or grains is necessary to derive the strain hardening models for this type of materials.Measurements available from the Numisheet benchmarks allow these models to be validated. At Corus, additional measured values are available from cross-die tests. This laboratory test can attain critical deformations by large variations in blank size and processing conditions. The tests are a powerful tool in optimising forming simulations prior

  4. Clinical factors of response in patients with advanced ovarian cancer participating in early phase clinical trials.

    Science.gov (United States)

    George, Angela; Kristeleit, Rebecca; Rafii, Saeed; Michie, Caroline O; Bowen, Rebecca; Michalarea, Vasiliki; van Hagen, Tom; Wong, Mabel; Rallis, Grigorios; Molife, L Rhoda; Lopez, Juanita; Banerji, Udai; Banerjee, Susana N; Gore, Martin E; de Bono, Johann S; Kaye, Stan B; Yap, Timothy A

    2017-05-01

    Drug resistance to conventional anticancer therapies is almost inevitable in patients with advanced ovarian cancer (AOC), limiting their available treatment options. Novel phase I trial therapies within a dedicated drug development unit may represent a viable alternative; however, there is currently little evidence for patient outcomes in such patients. To address this, we undertook a retrospective review of patients with AOC allocated to phase I trials in the Drug Development Unit at Royal Marsden Hospital (RMH) between June 1998 and October 2010. A total of 200 AOC patients with progressive disease were allocated to ≥1 trial each, with a total of 281 allocations. Of these, 135 (68%) patients commenced ≥1 trial (mean 1.4 [1-8]), totaling 216 allocated trials; 65 (32%) patients did not start due to deterioration resulting from rapidly progressive disease (63 patients) or patient choice (2 patients). Response Evaluation Criteria in Solid Tumours (RECIST) complete/partial responses (CR/PR) were observed in 43 (20%) of those starting trials, including those on poly(ADP-ribose) polymerase (PARP) inhibitors (18/79 [23%]), antiangiogenics (9/65 [14%]) and chemotherapy combinations (14/43 [33%]). Factors associated with CR/PR included: fewer prior treatments, platinum-sensitive disease, CR/PR with prior therapy, (the United States-based) Eastern Cooperative Oncology Group (ECOG) performance status score, fewer metastatic sites, higher albumin and haemoglobin levels, lower white cell counts and baseline CA125 levels, germline BRCA1/2 mutations and better RMH Prognostic Score. Mean survival was 32° months for patients who achieved CR/PR. Treatments were generally well tolerated. Most patients with AOC (134/200 [67%]) received ≥1 subsequent line of therapy after phase I trials. Our data suggest that phase I trial referrals should be considered earlier in the AOC treatment pathway and before the onset of rapid disease progression particularly with the emergence of

  5. Advances in radiographic NDI of pipe systems; Fortschritte bei der Durchstrahlungspruefung von Rohrleitungssystemen

    Energy Technology Data Exchange (ETDEWEB)

    Morgner, W. [NSQ HAUK, Ludwigshafen (Germany); Hauk, T. [NSQ HAUK, Ludwigshafen (Germany); Tschachlov, V. [NSQ HAUK, Tomsk (Russian Federation)

    1995-12-31

    The paper discusses the application of a small-sized betatron and its operational parameters, and its uses for very small angle tomography of medium-filled pipes or a thick weld. Other aspects discussed are the handling of large numbers of X-ray images by means of an X-ray manipulator, film digitalization, and data management of imaging data. (orig./MM) [Deutsch] Dieser Beitrag behandelt die Anwendung eines Kleinbetatrons und seiner Leistungsparameter, damit durchgefuehrte Durchstrahlungspruefungen an mediumgefuellten Rohren und eine an einer dicken Schweissnaht realisierte Wenigwinkeltomographie. Bezueglich der Beherrschung einer Grosszahl von Roentgenaufnahmen wird ueber einen Roentgenmanipulator, die Filmdigitalisierung und das Datenmanagement von Bilddaten berichtet. (orig./MM)

  6. FreedomCAR Advanced Traction Drive Motor Development Phase I

    Energy Technology Data Exchange (ETDEWEB)

    Ley, Josh (UQM Technologies, Inc.); Lutz, Jon (UQM Technologies, Inc.)

    2006-09-01

    The overall objective of this program is to design and develop an advanced traction motor that will meet the FreedomCAR and Vehicle Technologies (FCVT) 2010 goals and the traction motor technical targets. The motor specifications are given in Section 1.3. Other goals of the program include providing a cost study to ensure the motor can be developed within the cost targets needed for the automotive industry. The program has focused on using materials that are both high performance and low costs such that the performance can be met and cost targets are achieved. In addition, the motor technologies and machine design features must be compatible with high volume manufacturing and able to provide high reliability, efficiency, and ruggedness while simultaneously reducing weight and volume. Weight and volume reduction will become a major factor in reducing cost, material cost being the most significant part of manufacturing cost at high volume. Many motor technology categories have been considered in the past and present for traction drive applications, including: brushed direct current (DC), PM (PM) brushless dc (BLDC), alternating current (AC) induction, switched reluctance and synchronous reluctance machines. Of these machine technologies, PM BLDC has consistently demonstrated an advantage in terms of power density and efficiency. As rare earth magnet cost has declined, total cost may also be reduced over the other technologies. Of the many different configurations of PM BLDC machines, those which incorporate power production utilizing both magnetic torque as well as reluctance torque appear to have the most promise for traction applications. There are many different PM BLDC machine configurations which employ both of these torque producing mechanisms; however, most would fall into one of two categories--some use weaker magnets and rely more heavily on reluctance torque (reluctance-dominant PM machines), others use strong PMs and supplement with reluctance torque

  7. SAFETY AND ACTIVITY OF TEMSIROLIMUS AND BEVACIZUMAB IN PATIENTS WITH ADVANCED RENAL CELL CARCINOMA PREVIOUSLY TREATED WITH TYROSINE KINASE INHIBITORS: A PHASE 2 CONSORTIUM STUDY

    Science.gov (United States)

    Merchan, Jaime R.; Qin, Rui; Pitot, Henry; Picus, Joel; Liu, Glenn; Fitch, Tom; Maples, William J.; Flynn, Patrick J.; Fruth, Briant F.; Erlichman, Charles

    2015-01-01

    Purpose Bevacizumab or Temsirolimus regimens have clinical activity in the first line treatment of advanced renal cell carcinoma (RCC). This phase I/II trial was conducted to determine the safety of combining both agents and its efficacy in RCC patients who progressed on at least one prior anti-VEGF receptor tyrosine kinase inhibitor (RTKI) agent. Methods In the phase I portion, eligible patients were treated with Temsirolimus (25 mg IV weekly) and escalating doses of IV Bevacizumab (level 1=5mg/kg; level 2=10 mg/kg) every other week. The primary endpoint for the phase II portion (RTKI resistant patients) was the 6-month progression free rate. Secondary endpoints were response rate, toxicity evaluation, PFS and OS. Results MTD was not reached at the maximum dose administered in 12 phase I patients. Forty evaluable patients were treated with the phase II recommended dose (Temsirolimus 25 mg IV weekly and Bevacizumab 10 mg/kg IV every two weeks). The 6-month progression free rate was 40% (16/40 pts). Median PFS was 5.9 (4-7.8) months, and median OS was 20.6 (11.5-23.7) months. Partial response/stable/progressive disease were seen in 23%/63%/14% of patients. Most common grade 3-4 AEs included fatigue (17.8%), hypertriglyceridemia (11.1%), stomatitis (8.9%), proteinuria (8.9%), abdominal pain (6.7%), and anemia (6.7%). Baseline levels of serum sFLT-1 and VEGF-A were inversely correlated with PFS and OS, respectively. Conclusions Temsirolimus and Bevacizumab is a feasible combination in patients with advanced RCC previously exposed to oral anti-VEGF agents. The safety and efficacy results warrant further confirmatory studies in this patient population. PMID:25556030

  8. Diffusion, Thermal Properties and Chemical Compatibilities of Select MAX Phases with Materials For Advanced Nuclear Systems

    Energy Technology Data Exchange (ETDEWEB)

    Barsoum, Michel [Drexel Univ., Philadelphia, PA (United States); Bentzel, Grady [Drexel Univ., Philadelphia, PA (United States); Tallman, Darin J. [Drexel Univ., Philadelphia, PA (United States); Sindelar, Robert [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Garcia-Diaz, Brenda [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Hoffman, Elizabeth [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2016-04-04

    The demands of Gen IV nuclear power plants for long service life under neutron irradiation at high temperature are severe. Advanced materials that would withstand high temperatures (up to 1000+ ºC) to high doses in a neutron field would be ideal for reactor internal structures and would add to the long service life and reliability of the reactors. The objective of this work is to investigate the chemical compatibility of select MAX with potential materials that are important for nuclear energy, as well as to measure the thermal transport properties as a function of neutron irradiation. The chemical counterparts chosen for this work are: pyrolytic carbon, SiC, U, Pd, FLiBe, Pb-Bi and Na, the latter 3 in the molten state. The thermal conductivities and heat capacities of non-irradiated MAX phases will be measured.

  9. A single-arm, multicenter, safety-monitoring, phase IV study of icotinib in treating advanced non-small cell lung cancer (NSCLC).

    Science.gov (United States)

    Hu, Xingsheng; Han, Baohui; Gu, Aiqin; Zhang, Yiping; Jiao, Shun Chang; Wang, Chang-Li; He, Jintao; Jia, Xueke; Zhang, Li; Peng, Jiewen; Wu, Meina; Ying, Kejing; Wang, Junye; Ma, Kewei; Zhang, Shucai; You, Changxuan; Tan, Fenlai; Wang, Yinxiang; Ding, Lieming; Sun, Yan

    2014-11-01

    The phase 3 ICOGEN trial established the non-inferiority of icotinib to gefitinib in terms of progression-free survival (PFS) in non-small cell lung cancer (NSCLC) patients, and this led to the approval of icotinib for NSCLC by the China Food and Drug Administration. A phase 4 study was conducted to assess the safety and efficacy of icotinib in a broad range of patients with advanced NSCLC across China. This study retrospectively analyzed data from unresectable, recurrent, and/or advanced NSCLC patients who received oral icotinib 125 mg three times per day. The primary endpoint was safety. The secondary endpoints included objective response rate (ORR) and disease control rate (DCR), which were investigated overall and in subgroups such as patients with an EGFR mutation and elderly patients. Between August, 2011 and August, 2012, a total of 6087 advanced NSCLC patients were registered in this study, of which 5549 were evaluable for safety and tumor response. The median age was 63 years (range 21-95 years), and 1571 (28.3%) patients were over the age of 70. The majority of patients were non-smokers, and had adenocarcinoma and stage IV disease. The overall incidence of adverse drug reactions (ADRs) of any grade was 31.5%. The most common ADRs included rash (17.4%) and diarrhea (8.5%), and three patients experienced interstitial lung disease (ILD). The ORR and DCR were 30.0% and 80.6%, respectively, for the overall population, and 33.4% and 81.2%, 30.3% and 80.3%, and 30.4% and 89.3%, for first-line, second-line, and third-line or multiple line subsets, respectively. In 665 EGFR-mutated patients who were evaluable for tumor response, the ORR and DCR were 49.2% (327/665) and 92.3% (614/665), respectively. The data from over 6000 patients was consistent with the results of the ICOGEN study. Icotinib demonstrated a favorable toxicity profile and efficacy in the routine clinical setting. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  10. Axitinib in combination with pembrolizumab in patients with advanced renal cell cancer: a non-randomised, open-label, dose-finding, and dose-expansion phase 1b trial.

    Science.gov (United States)

    Atkins, Michael B; Plimack, Elizabeth R; Puzanov, Igor; Fishman, Mayer N; McDermott, David F; Cho, Daniel C; Vaishampayan, Ulka; George, Saby; Olencki, Thomas E; Tarazi, Jamal C; Rosbrook, Brad; Fernandez, Kathrine C; Lechuga, Mariajose; Choueiri, Toni K

    2018-03-01

    Previous studies combining PD-1 checkpoint inhibitors with tyrosine kinase inhibitors of the VEGF pathway have been characterised by excess toxicity, precluding further development. We hypothesised that axitinib, a more selective VEGF inhibitor than others previously tested, could be combined safely with pembrolizumab (anti-PD-1) and yield antitumour activity in patients with treatment-naive advanced renal cell carcinoma. In this ongoing, open-label, phase 1b study, which was done at ten centres in the USA, we enrolled patients aged 18 years or older who had advanced renal cell carcinoma (predominantly clear cell subtype) with their primary tumour resected, and at least one measureable lesion, Eastern Cooperative Oncology Group performance status 0-1, controlled hypertension, and no previous systemic therapy for renal cell carcinoma. Eligible patients received axitinib plus pembrolizumab in a dose-finding phase to estimate the maximum tolerated dose, and additional patients were enrolled into a dose-expansion phase to further establish safety and determine preliminary efficacy. Axitinib 5 mg was administered orally twice per day with pembrolizumab 2 mg/kg given intravenously every 3 weeks. We assessed safety in all patients who received at least one dose of axitinib or pembrolizumab; antitumour activity was assessed in all patients who received study treatment and had an adequate baseline tumour assessment. The primary endpoint was investigator-assessed dose-limiting toxicity during the first two cycles (6 weeks) to estimate the maximum tolerated dose and recommended phase 2 dose. This study is registered with ClinicalTrials.gov, number NCT02133742. Between Sept 23, 2014, and March 25, 2015, we enrolled 11 patients with previously untreated advanced renal cell carcinoma to the dose-finding phase and between June 3, 2015, and Oct 13, 2015, we enrolled 41 patients to the dose-expansion phase. All 52 patients were analysed together. No unexpected toxicities were

  11. Off-bucket Proton Losses during Ramping

    CERN Document Server

    Catalan-Lasheras, N

    1998-01-01

    In this paper, we report a study undertaken to determine whether longitudinal and transverse amplitudes become coupled before the loss of the off-bucket protons during the ramp. We compute the synchro tron as well as the betatron tune changes with momentum and determine if synchro-betatron resonances blow-up the transverse particle amplitude. A strong coupling might allow a betatron cleaning of the se particles before they are outside the momentum acceptance of the machine. We show that this is not the case, justifying the need of momentum cleaning.

  12. Concept selection for advanced low-emission coal fired boiler

    Energy Technology Data Exchange (ETDEWEB)

    Gorrell, R.L. [Babcock and Wilcox Co., Barberton, OH (United States); Rodgers, L.W.; Farthing, G.A. [Babcock and Wilcox Co., Alliance, OH (United States)

    1993-12-31

    The Babcock & Wilcox Company (B&W), under contract to the US Department of Energy (DOE) with subcontract to Physical Sciences, Inc. (PSIT), the Massachusetts Institute of Technology (MIT) and United Engineers and Constructors (UE&C) has begun development of an advanced low-emission boiler system (LEBS). The initial phase of this multi-phase program required a thorough review and assessment of potential advanced technologies and techniques for control of combustion and flue gas emissions. Results of this assessment are presented in this paper.

  13. Continuous-Scan Phased Array Measurement Methods for Turbofan Engine Acoustic Testing, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — ATA Engineering, Inc., (ATA) proposes an SBIR project to advance the technology readiness level (TRL) of a method for measuring phased array acoustic data for...

  14. Metronomic treatment of advanced non-small-cell lung cancer with daily oral vinorelbine – a Phase I trial

    Directory of Open Access Journals (Sweden)

    Guetz S

    2017-02-01

    Full Text Available Sylvia Guetz,1,* Amanda Tufman,2,* Joachim von Pawel,3 Achim Rittmeyer,4 Astrid Borgmeier,2 Pierre Ferré,5 Birgit Edlich,6 Rudolf Maria Huber2 1Ev. Diakonissenkrankenhaus Leipzig, Leipzig, 2University Hospital Munich and Thoracic Oncology Centre Munich, Member of the German Center for Lung Research, Comprehensive Pneumology Center Munich (DZL CPC-M, Munich, 3Asklepios Fachkliniken Muenchen-Gauting, Gauting, 4Lungenfachklinik Immenhausen, Immenhausen, Germany; 5Pierre Fabre Pharmaceuticals, Oncology Research and Development Center, Toulouse, France; 6Pierre Fabre Pharma GmbH, Freiburg, Germany *These authors contributed equally to this work Micro-abstract: In a Phase I dose-finding study of metronomic daily oral vinorelbine in advanced non-small-cell lung cancer, a recommended dose was established for this therapeutic approach. In addition, this trial revealed promising efficacy data and an acceptable tolerability profile. The observed vinorelbine blood concentrations suggest continuous anti-angiogenic coverage. Introduction: We present a Phase I dose-finding study investigating metronomic daily oral vinorelbine (Navelbine® Oral, NVBo in advanced non-small-cell lung cancer (NSCLC. Patients and methods: Patients with stage III/IV NSCLC received daily NVBo at fixed dose levels of 20–50 mg/d for 21 days of each 4-week cycle. Primary end point was the maximum tolerated dose. Secondary end points included tumor response, time to progression (TTP, overall survival (OS and tolerability. Results: Twenty-seven patients with advanced NSCLC were enrolled. Most of them were extensively pretreated. Daily NVBo was well tolerated up to 30 mg/d. At 40 mg/d, two of five patients experienced dose-limiting toxicities (DLTs. Three of six patients had DLTs at the 50 mg/d level. The recommended dose was established at 30 mg/d in cycle 1, with escalation to 40 mg/d in cycle 2, if tolerated. Pharmacokinetic analyses showed continuous blood exposure over 21

  15. Metal Advanced Manufacturing Bot-Assisted Assembly (MAMBA) Process, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Tethers Unlimited, Inc. (TUI) proposes to develop the Metal Advanced Manufacturing Bot-Assisted Assembly (MAMBA) Process, a robotically managed metal press and...

  16. Advanced On Board Inert Gas Generation System (OBBIGS), Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Valcor Engineering Corporation proposes to develop an advanced On Board Inert Gas Generation System, OBIGGS, for aircraft fuel tank inerting to prevent hazardous...

  17. NATO Advanced Study Institute on Advanced Physical Oceanographic Numerical Modelling

    CERN Document Server

    1986-01-01

    This book is a direct result of the NATO Advanced Study Institute held in Banyuls-sur-mer, France, June 1985. The Institute had the same title as this book. It was held at Laboratoire Arago. Eighty lecturers and students from almost all NATO countries attended. The purpose was to review the state of the art of physical oceanographic numerical modelling including the parameterization of physical processes. This book represents a cross-section of the lectures presented at the ASI. It covers elementary mathematical aspects through large scale practical aspects of ocean circulation calculations. It does not encompass every facet of the science of oceanographic modelling. We have, however, captured most of the essence of mesoscale and large-scale ocean modelling for blue water and shallow seas. There have been considerable advances in modelling coastal circulation which are not included. The methods section does not include important material on phase and group velocity errors, selection of grid structures, advanc...

  18. High Efficiency Advanced Lightweight Fuel Cell (HEAL-FC), Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Infinity's High Efficiency Advanced Lightweight Fuel Cell (HEAL FC) is an improved version of its current fuel cell technology developed for space applications. The...

  19. Advanced computational model for three-phase slurry reactors

    International Nuclear Information System (INIS)

    Goodarz Ahmadi

    2001-10-01

    In the second year of the project, the Eulerian-Lagrangian formulation for analyzing three-phase slurry flows in a bubble column is further developed. The approach uses an Eulerian analysis of liquid flows in the bubble column, and makes use of the Lagrangian trajectory analysis for the bubbles and particle motions. An experimental set for studying a two-dimensional bubble column is also developed. The operation of the bubble column is being tested and diagnostic methodology for quantitative measurements is being developed. An Eulerian computational model for the flow condition in the two-dimensional bubble column is also being developed. The liquid and bubble motions are being analyzed and the results are being compared with the experimental setup. Solid-fluid mixture flows in ducts and passages at different angle of orientations were analyzed. The model predictions were compared with the experimental data and good agreement was found. Gravity chute flows of solid-liquid mixtures is also being studied. Further progress was also made in developing a thermodynamically consistent model for multiphase slurry flows with and without chemical reaction in a state of turbulent motion. The balance laws are obtained and the constitutive laws are being developed. Progress was also made in measuring concentration and velocity of particles of different sizes near a wall in a duct flow. The technique of Phase-Doppler anemometry was used in these studies. The general objective of this project is to provide the needed fundamental understanding of three-phase slurry reactors in Fischer-Tropsch (F-T) liquid fuel synthesis. The other main goal is to develop a computational capability for predicting the transport and processing of three-phase coal slurries. The specific objectives are: (1) To develop a thermodynamically consistent rate-dependent anisotropic model for multiphase slurry flows with and without chemical reaction for application to coal liquefaction. Also establish the

  20. Reminder of Lagrange-Hamilton formalism and of the corpuscular optics invariants; Rappel du formalisme de Lagrange-Hamilton et sur les invariants de l'optique corpusculaire

    Energy Technology Data Exchange (ETDEWEB)

    Griess, F.

    1958-03-14

    Hamiltonian formalism - Canonical transformations - Invariants of Liouville, Helmholtz-Lagrange, Busch, Stoermer and Lagrange - Synchrotron's Hamiltonian - Betatron oscillation damping. (author) [French] Formalisme Hamiltonien. Transformations canoniques. Invariants de Liouville, Helmholtz-Lagrange, Busch, Stoermer et Lagrange, Hamiltonien pour le synchrotron, Amortissement des oscillations betatrons (auteur)

  1. Randomized phase III study comparing paclitaxel/cisplatin/ gemcitabine and gemcitabine/cisplatin in patients with locally advanced or metastatic urothelial cancer without prior systemic therapy: EORTC intergroup study 30987

    NARCIS (Netherlands)

    J. Bellmunt (Joaquim); H. von der Maase (Hans); G.M. Mead (Graham); I. Skoneczna (I.); M. de Santis (Maria); G. Daugaard (Gedske); J. Boehle; C. Chevreau (Christine); L. Paz-Ares (Luis); L.R. Laufman (Leslie); E. Winquist (Eric); R. Raghavan (Raghu); S. Marreaud (Sandrine); S. Collette (Sandra); R. Sylvester (Richard); R. de Wit (Ronald)

    2012-01-01

    textabstractPurpose: The combination of gemcitabine plus cisplatin (GC) is a standard regimen in patients with locally advanced or metastatic urothelial cancer. A phase I/II study suggested that a three-drug regimen that included paclitaxel had greater antitumor activity and might improve survival.

  2. Advanced Insulation Materials for Cryogenic Propellant Storage Applications, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Advanced Materials Technology, Inc responds to the NASA solicitation Topic X9 entitled "Propulsion and Propellant Storage" under subtopic X9-01, "Long Term Cryogenic...

  3. Recent rebatron studies

    International Nuclear Information System (INIS)

    Prakash, A.; Marsh, S.J.; Dialetis, D.; Agritellis, C.; Sprangle, P.; Kapetanakos, C.A.

    1985-01-01

    The rebatron is a high-current compact accelerator concept with differs from the modified betatron and the stellatron. In the latter devices, the acceleration mechanism is the relatively slow betatron mechanism. In the rebatron, there is rapid acceleration of the electron as the beam repeatedly passes through a small (few centimeters long) high-gradient accelerating gap, the beam being recirculated through the gap in a single toroidal beam line of major radius ∼ 1m. Whereas the betatron acceleration typically boosts the electron energy by 2 MeV per pass so that the beam attains a given final energy rapidly (in a few μsec) in a few revolutions, as compared to thousands of revolutions needed in a 50 MeV betatron. Hence the name REBATRON (Rapid Electron Beam Acceleration device). The rapid acceleration eases the problem of growth of beam instabilities and makes fractional synchrotron losses small

  4. Advanced heat pump for the recovery of volatile organic compounds. Phase 1, Conceptual design of an advanced Brayton cycle heat pump for the recovery of volatile organic compounds: Final report

    Energy Technology Data Exchange (ETDEWEB)

    1992-03-01

    Emissions of Volatile Organic Compounds (VOC) from stationary industrial and commercial sources represent a substantial portion of the total US VOC emissions. The ``Toxic-Release Inventory`` of The US Environmental Protection Agency estimates this to be at about 3 billion pounds per year (1987 estimates). The majority of these VOC emissions are from coating processes, cleaning processes, polymer production, fuel production and distribution, foam blowing,refrigerant production, and wood products production. The US Department of Energy`s (DOE) interest in the recovery of VOC stems from the energy embodied in the recovered solvents and the energy required to dispose of them in an environmentally acceptable manner. This Phase I report documents 3M`s work in close working relationship with its subcontractor Nuclear Consulting Services (Nucon) for the preliminary conceptual design of an advanced Brayton cycle heat pump for the recovery of VOC. Nucon designed Brayton cycle heat pump for the recovery of methyl ethyl ketone and toluene from coating operations at 3M Weatherford, OK, was used as a base line for the work under cooperative agreement between 3M and ODE. See appendix A and reference (4) by Kovach of Nucon. This cooperative agreement report evaluates and compares an advanced Brayton cycle heat pump for solvent recovery with other competing technologies for solvent recovery and reuse. This advanced Brayton cycle heat pump is simple (very few components), highly reliable (off the shelf components), energy efficient and economically priced.

  5. Investigations of the reflood-phase after a loss-of-coolant-accident of an advanced pressurized water reactor (APWR)

    International Nuclear Information System (INIS)

    Schumann, S.; Oldekop, W.

    1983-01-01

    Differences between a high converting advanced pressurized-water reactor (APWR) and a conventional PWR, which are relevant to the reflood-phase after LOCA are presented. The used code and its verification by PWR-reflood experiments is explained. Comparative calculations for APWR and PWR with several conservative assumptions for example cold-leg-injection only, yield nearly the same maximum midplane-temperatures for the average-channel. For the APWR, however, the upper half of the rod shows higher temperatures. Quenchfront and core-water-level increase more slowly. The differences in the reflood-thermohydraulics are analysed in detail. A conservative hot-channel calculation shows maximum temperatures of about 920 0 C. Finally the influence of conservative assumptions is described and the necessity of experiments pointed out. (orig.)

  6. Advanced Nanostructured Cathode for Ultra High Specific Energy Lithium Ion Batteries, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Integrate advanced nanotechnology with energy storage technology to develop advanced cathode materials for use in Li-ion batteries while maintaining a high level of...

  7. Phase I study of conformal radiotherapy with concurrent gemcitabine in locally advanced bladder cancer

    International Nuclear Information System (INIS)

    Sangar, Vijay K.; McBain, Catherine A.; Lyons, Jeanette; Ramani, Vijay; Logue, John; Wylie, James; Clarke, Noel W.; Cowan, Richard A.

    2005-01-01

    Purpose: A prospective phase I trial was conducted to determine the maximal tolerated dose of gemcitabine given once weekly during hypofractionated conformal radiotherapy to patients with locally advanced transitional cell carcinoma of the bladder. Eight male patients, median age 69 years, with Stage T2 (n = 4) or T3 (n = 4) N0M0, were enrolled in cohorts of 3. Treatment comprised conformal radiotherapy (52.5 Gy in 20 fractions) within 4 weeks, with concurrent gemcitabine once weekly for four cycles. The weekly gemcitabine dose was escalated from 100 mg/m 2 in increments of 50 mg/m 2 per cohort. Dose-limiting toxicity was defined as any acute Radiation Therapy Oncology Group (RTOG) toxicity Grade 3 or greater arising in >1 of 3 patients in each cohort. Tumor response was assessed cystoscopically and radiologically at 3 months. Results: All 8 patients completed radiotherapy, and 6 of 8 completed chemoradiotherapy. No acute toxicity greater than RTOG Grade 1 was seen with gemcitabine at 100 mg/m 2 . Dose-limiting toxicity was observed at 150 mg/m 2 with Grade 3 toxicity seen in 2 of 2 patients (one bladder, one bowel). An additional 3 patients received 100 mg/m 2 with minimal toxicity. No hematologic toxicity was encountered. A complete response was seen in 7 (87.5%) of 8 patients, all of whom were disease free at a median follow-up of 19.5 months (range, 14-23 months). No late toxicity (greater than RTOG Grade 0) has been observed. Conclusion: The maximal tolerated dose for gemcitabine given once weekly with concurrent hypofractionated conformal bladder radiotherapy was 150 mg/m 2 , with a maximal recommended dose of 100 mg/m 2 . This dose regimen has now entered Phase II clinical trials

  8. Reconstruction of lattice parameters and beam momentum distribution from turn-by-turn beam position monitor readings in circular accelerators

    Directory of Open Access Journals (Sweden)

    C. S. Edmonds

    2014-05-01

    Full Text Available In high chromaticity circular accelerators, rapid decoherence of the betatron motion of a particle beam can make the measurement of lattice and bunch values, such as Courant-Snyder parameters and betatron amplitude, difficult. A method for reconstructing the momentum distribution of a beam from beam position measurements is presented. Further analysis of the same beam position monitor data allows estimates to be made of the Courant-Snyder parameters and the amplitude of coherent betatron oscillation of the beam. The methods are tested through application to data taken on the linear nonscaling fixed field alternating gradient accelerator, EMMA.

  9. Nivolumab-Based Treatments for Advanced Melanoma

    Science.gov (United States)

    A summary of results from an international, double-blind, randomized phase III trial testing the combination of nivolumab (Opdivo®) and ipilimumab (Yervoy®) against nivolumab alone and ipilimumab alone in patients with advanced melanoma.

  10. Digital polarization holography advancing geometrical phase optics.

    Science.gov (United States)

    De Sio, Luciano; Roberts, David E; Liao, Zhi; Nersisyan, Sarik; Uskova, Olena; Wickboldt, Lloyd; Tabiryan, Nelson; Steeves, Diane M; Kimball, Brian R

    2016-08-08

    Geometrical phase or the fourth generation (4G) optics enables realization of optical components (lenses, prisms, gratings, spiral phase plates, etc.) by patterning the optical axis orientation in the plane of thin anisotropic films. Such components exhibit near 100% diffraction efficiency over a broadband of wavelengths. The films are obtained by coating liquid crystalline (LC) materials over substrates with patterned alignment conditions. Photo-anisotropic materials are used for producing desired alignment conditions at the substrate surface. We present and discuss here an opportunity of producing the widest variety of "free-form" 4G optical components with arbitrary spatial patterns of the optical anisotropy axis orientation with the aid of a digital spatial light polarization converter (DSLPC). The DSLPC is based on a reflective, high resolution spatial light modulator (SLM) combined with an "ad hoc" optical setup. The most attractive feature of the use of a DSLPC for photoalignment of nanometer thin photo-anisotropic coatings is that the orientation of the alignment layer, and therefore of the fabricated LC or LC polymer (LCP) components can be specified on a pixel-by-pixel basis with high spatial resolution. By varying the optical magnification or de-magnification the spatial resolution of the photoaligned layer can be adjusted to an optimum for each application. With a simple "click" it is possible to record different optical components as well as arbitrary patterns ranging from lenses to invisible labels and other transparent labels that reveal different images depending on the side from which they are viewed.

  11. Advanced Virgo: a second-generation interferometric gravitational wave detector

    NARCIS (Netherlands)

    Acernese, F.; Bulten, H.J.; Rabeling, D.S.; van den Brand, J.F.J.

    2015-01-01

    Advanced Virgo is the project to upgrade the Virgo interferometric detector of gravitational waves, with the aim of increasing the number of observable galaxies (and thus the detection rate) by three orders of magnitude. The project is now in an advanced construction phase and the assembly and

  12. Phase 2 Neoadjuvant Treatment Intensification Trials in Rectal Cancer

    DEFF Research Database (Denmark)

    Teo, Mark T W; McParland, Lucy; Appelt, Ane L

    2018-01-01

    PURPOSE: Multiple phase 2 trials of neoadjuvant treatment intensification in locally advanced rectal cancer have reported promising efficacy signals, but these have not translated into improved cancer outcomes in phase 3 trials. Improvements in phase 2 trial design are needed to reduce these fals...

  13. Experimental Validation of Advanced Dispersed Fringe Sensing (ADFS) Algorithm Using Advanced Wavefront Sensing and Correction Testbed (AWCT)

    Science.gov (United States)

    Wang, Xu; Shi, Fang; Sigrist, Norbert; Seo, Byoung-Joon; Tang, Hong; Bikkannavar, Siddarayappa; Basinger, Scott; Lay, Oliver

    2012-01-01

    Large aperture telescope commonly features segment mirrors and a coarse phasing step is needed to bring these individual segments into the fine phasing capture range. Dispersed Fringe Sensing (DFS) is a powerful coarse phasing technique and its alteration is currently being used for JWST.An Advanced Dispersed Fringe Sensing (ADFS) algorithm is recently developed to improve the performance and robustness of previous DFS algorithms with better accuracy and unique solution. The first part of the paper introduces the basic ideas and the essential features of the ADFS algorithm and presents the some algorithm sensitivity study results. The second part of the paper describes the full details of algorithm validation process through the advanced wavefront sensing and correction testbed (AWCT): first, the optimization of the DFS hardware of AWCT to ensure the data accuracy and reliability is illustrated. Then, a few carefully designed algorithm validation experiments are implemented, and the corresponding data analysis results are shown. Finally the fiducial calibration using Range-Gate-Metrology technique is carried out and a <10nm or <1% algorithm accuracy is demonstrated.

  14. Ion acceleration in the plasma focus

    International Nuclear Information System (INIS)

    Deutsch, R.

    1982-09-01

    Experimental informations are used to estimate the time dependence of the current density in the plasma focus and the electromagnetic field is determined from the Maxwell equations. The acceleration of the ions in these fields is studied. A detailed analysis of the acceleration in the compression phase, in the expansion phase and during the evolution of the m=O instability is made. It is shown, that the appearance of fast selffocused quasineutral electron beams, as a result of the betatron acceleration, has a decisive importance in the ion acceleration during the m=O constriction. Models for electromagnetic ion acceleration are described for each phase. A concordance with many experimental results can be observed. (orig.)

  15. Development of the advanced phased array UT technique for accurate sizing of cracks in the nozzle welding

    International Nuclear Information System (INIS)

    Nishida, Jun-ichiro; Kawanami, Seiichi; Ideo, Mitsushi; Matsuura, Takayuki; Chigusa, Naoki; Hirano, Shinro; Sera, Takehiko

    2010-01-01

    Recently, preventive maintenance tasks for welding of safe-end nozzles of reactor vessels and steam generators of PWRs in Japan had been carried out sequentially. Before the maintenance tasks, inspection services were carried out and several crack indications were found by eddy current testing (ECT). These indications were found in the welding which made by 600 series nickel base alloy and evaluated as stress corrosion cracks which were oriented to the axial direction of the nozzle. Then investigations to evaluate the depth of cracks were carried out by ultrasonic testing (UT) from inner surface of the nozzles. However they were difficult to evaluate the depth of cracks due to the high attenuation of the ultrasonic propagation caused by large grain structure of welding. And also it was required high resolution near surface region for accurate sizing. Therefore development of advanced phased array UT techniques specialized for the sizing at this portion was carried out. This paper reports the development status and verification test results. Firstly simulations of the ultrasonic propagation in the welding were carried out to optimize beam profiles of phased array probes. Next prototype probes were manufactured and verification tests were conducted to evaluate the accuracy of depth sizing. It is shown that the developed techniques have high sizing accuracy for artificial stress corrosion cracks in the welding. (author)

  16. Utility Advanced Turbine Systems (ATS) technology readiness testing

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-05-01

    The overall objective of the Advanced Turbine System (ATS) Phase 3 Cooperative Agreement between GE and the US Department of Energy (DOE) is the development of the GE 7H and 9H combined cycle power systems. The major effort will be expended on detail design. Validation of critical components and technologies will be performed, including: hot gas path component testing, sub-scale compressor testing, steam purity test trials, and rotational heat transfer confirmation testing. Processes will be developed to support the manufacture of the first system, which was to have been sited and operated in Phase 4 but will now be sited and operated commercially by GE. This change has resulted horn DOE's request to GE for deletion of Phase 4 in favor of a restructured Phase 3 (as Phase 3R) to include fill speed, no load (FSNL) testing of the 7H gas turbine. Technology enhancements that are not required for the first machine design but will be critical for future ATS advances in performance, reliability, and costs will be initiated. Long-term tests of materials to confirm design life predictions will continue. A schematic of the GE H machine is shown.

  17. ADVANCED TURBINE SYSTEMS PROGRAM

    Energy Technology Data Exchange (ETDEWEB)

    Gregory Gaul

    2004-04-21

    Natural gas combustion turbines are rapidly becoming the primary technology of choice for generating electricity. At least half of the new generating capacity added in the US over the next twenty years will be combustion turbine systems. The Department of Energy has cosponsored with Siemens Westinghouse, a program to maintain the technology lead in gas turbine systems. The very ambitious eight year program was designed to demonstrate a highly efficient and commercially acceptable power plant, with the ability to fire a wide range of fuels. The main goal of the Advanced Turbine Systems (ATS) Program was to develop ultra-high efficiency, environmentally superior and cost effective competitive gas turbine systems for base load application in utility, independent power producer and industrial markets. Performance targets were focused on natural gas as a fuel and included: System efficiency that exceeds 60% (lower heating value basis); Less than 10 ppmv NO{sub x} emissions without the use of post combustion controls; Busbar electricity that are less than 10% of state of the art systems; Reliability-Availability-Maintainability (RAM) equivalent to current systems; Water consumption minimized to levels consistent with cost and efficiency goals; and Commercial systems by the year 2000. In a parallel effort, the program was to focus on adapting the ATS engine to coal-derived or biomass fuels. In Phase 1 of the ATS Program, preliminary investigators on different gas turbine cycles demonstrated that net plant LHV based efficiency greater than 60% was achievable. In Phase 2 the more promising cycles were evaluated in greater detail and the closed-loop steam-cooled combined cycle was selected for development because it offered the best solution with least risk for achieving the ATS Program goals for plant efficiency, emissions, cost of electricity and RAM. Phase 2 also involved conceptual ATS engine and plant design and technology developments in aerodynamics, sealing

  18. Advanced Technology Cloud Particle Probe for UAS, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — In Phase II SPEC will design, fabricate and flight test a state-of-the-art combined cloud particle probe called the Hawkeye. Hawkeye is the culmination of two...

  19. Advanced Worker Protection System

    International Nuclear Information System (INIS)

    1996-04-01

    The Advanced Worker Protection System (AWPS) is a liquid-air-based, self-contained breathing and cooling system with a duration of 2 hrs. AWPS employs a patented system developed by Oceaneering Space Systems (OSS), and was demonstrated at their facility in Houston, TX as well as at Kansas State University, Manhattan. The heart of the system is the life-support backpack that uses liquid air to provide cooling as well as breathing gas to the worker. The backpack is combined with advanced protective garments, an advanced liquid cooling garment (LCG), a respirator, and communications and support equipment. The prototype unit development and testing under Phase 1 has demonstrated that AWPS has the ability to meet performance criteria. These criteria were developed with an understanding of both the AWPS capabilities and the DOE decontamination and decommissioning (D and D) activities protection needs

  20. Scaling Laws for Dynamic Aperture due to Chromatic Sextupoles

    CERN Document Server

    Scandale, Walter

    1997-01-01

    Scaling laws for the dynamic aperture due to chromatic sextupoles are investigated. The problem is addressed in a simplified lattice model containing 4 N identical cells and one linear betatron phase shifter to break the overall cell-lattice symmetry. Two families of chromatic sextupoles are used to compensate the natural chromaticity. Analytical formulae for the dynamic apertur as a function of the number of cells and of the cell length are found and confirmed through computer tracking.

  1. Liquid Crystals - The 'Fourth' Phase of Matter

    Indian Academy of Sciences (India)

    possibilities of novel technological applications. Liquid crystalline materials ... advanced instrumentation, including laptops and futuristic flat panel displays. .... The twist grain-boundary phase is formed when the layers of a smectic A phase are .... the optic axis) is uniformly oriented parallel to the glass plate. (see Figure IIa).

  2. Final 6D Muon Ionization Colling using Strong Focusing Quadrupoles

    Energy Technology Data Exchange (ETDEWEB)

    Hart, T. L. [Mississippi U.; Acosta, J. G. [Mississippi U.; Cremaldi, L. M. [Mississippi U.; Oliveros, S. J. [Mississippi U.; Summers, D. J. [Mississippi U.; Neuffer, D. V. [Fermilab

    2016-11-15

    Abstract Low emittance muon beam lines and muon colliders are potentially a rich source of BSM physics for future exper- imenters. A muon beam normalized emittance of ax,y,z = (280, 280, 1570)µm has been achieved in simulation with short solenoids and a betatron function of 3 cm. Here we use ICOOL and MAD-X to explore using a 400 MeV/c muon beam and strong focusing quadrupoles to achieve a normalized transverse emittance of 100 µm and complete 6D cooling. The low beta regions, as low as 5 mm, produced by the quadrupoles are occupied by dense, low Z absorbers, such as lithium hydride or beryllium, that cool the beam transversely. Equilibrium transverse emittance is linearly proportional to the transverse betatron function. Reverse emittance exchange with septa and/or wedges is then used to decrease transverse emittance from 100 to 25 µm at the expense of longitudinal emittance for a high energy lepton collider. Cooling challenges include chromaticity correction, ssband overlap, quadrupole acceptance, and staying in phase with RF.

  3. Combined Ramp and Squeeze to 6.5 TeV in the LHC

    CERN Document Server

    Solfaroli Camillocci, Matteo; Tomás, Rogelio; Wenninger, Jorg

    2016-01-01

    The cycle of the LHC is composed of an energy ramp followed by a betatron squeeze, needed to reduce the beta- star value in the interaction points. Since Run 1, studies have been carried out to investigate the feasibility of combining the two operations, thus considerably reducing the duration of the operational cycle. In Run 2, the LHC is operating at the energy of 6.5 TeV that requires a much longer cycle than that of Run 1. Therefore, the performance gains from a Combined Ramp and Squeeze (CRS) is more interesting. Merging the energy ramp and the betatron squeeze could result in a gain of several minutes for each LHC cycle. With increasing maturity of LHC operation, it is now possible to envisage more complex beam manipulations; this paper describes the first machine experiment with beam, aiming at validating the combination of ramp and squeeze, which was performed in 2015, during a machine development phase. The operation experience with the LHC run at 2.51 TeV, when CRS down to 4 meters was deployed and ...

  4. Independent component analysis applied to long bunch beams in the Los Alamos Proton Storage Ring

    Science.gov (United States)

    Kolski, Jeffrey S.; Macek, Robert J.; McCrady, Rodney C.; Pang, Xiaoying

    2012-11-01

    Independent component analysis (ICA) is a powerful blind source separation (BSS) method. Compared to the typical BSS method, principal component analysis, ICA is more robust to noise, coupling, and nonlinearity. The conventional ICA application to turn-by-turn position data from multiple beam position monitors (BPMs) yields information about cross-BPM correlations. With this scheme, multi-BPM ICA has been used to measure the transverse betatron phase and amplitude functions, dispersion function, linear coupling, sextupole strength, and nonlinear beam dynamics. We apply ICA in a new way to slices along the bunch revealing correlations of particle motion within the beam bunch. We digitize beam signals of the long bunch at the Los Alamos Proton Storage Ring with a single device (BPM or fast current monitor) for an entire injection-extraction cycle. ICA of the digitized beam signals results in source signals, which we identify to describe varying betatron motion along the bunch, locations of transverse resonances along the bunch, measurement noise, characteristic frequencies of the digitizing oscilloscopes, and longitudinal beam structure.

  5. Independent component analysis applied to long bunch beams in the Los Alamos Proton Storage Ring

    Directory of Open Access Journals (Sweden)

    Jeffrey S. Kolski

    2012-11-01

    Full Text Available Independent component analysis (ICA is a powerful blind source separation (BSS method. Compared to the typical BSS method, principal component analysis, ICA is more robust to noise, coupling, and nonlinearity. The conventional ICA application to turn-by-turn position data from multiple beam position monitors (BPMs yields information about cross-BPM correlations. With this scheme, multi-BPM ICA has been used to measure the transverse betatron phase and amplitude functions, dispersion function, linear coupling, sextupole strength, and nonlinear beam dynamics. We apply ICA in a new way to slices along the bunch revealing correlations of particle motion within the beam bunch. We digitize beam signals of the long bunch at the Los Alamos Proton Storage Ring with a single device (BPM or fast current monitor for an entire injection-extraction cycle. ICA of the digitized beam signals results in source signals, which we identify to describe varying betatron motion along the bunch, locations of transverse resonances along the bunch, measurement noise, characteristic frequencies of the digitizing oscilloscopes, and longitudinal beam structure.

  6. Phase II study on paclitaxel in patients with recurrent, metastatic or locally advanced vulvar cancer not amenable to surgery or radiotherapy: a study of the EORTC-GCG (European Organisation for Research and Treatment of Cancer--Gynaecological Cancer Group)

    NARCIS (Netherlands)

    Witteveen, P. O.; van der Velden, J.; Vergote, I.; Guerra, C.; Scarabeli, C.; Coens, C.; Demonty, G.; Reed, N.

    2009-01-01

    No standard treatment options are available for patients with advanced, recurrent or metastatic vulvar carcinoma not amenable for locoregional treatment. In this phase II study, patients with advanced vulvar cancer received paclitaxel (Taxol) every 3 weeks for up to 10 cycles. Primary objective was

  7. Gymnastics in Phase Space

    Energy Technology Data Exchange (ETDEWEB)

    Chao, Alexander Wu; /SLAC

    2012-03-01

    As accelerator technology advances, the requirements on accelerator beam quality become increasingly demanding. Facing these new demands, the topic of phase space gymnastics is becoming a new focus of accelerator physics R&D. In a phase space gymnastics, the beam's phase space distribution is manipulated and precision tailored to meet the required beam qualities. On the other hand, all realization of such gymnastics will have to obey accelerator physics principles as well as technological limitations. Recent examples of phase space gymnastics include Emittance exchanges, Phase space exchanges, Emittance partitioning, Seeded FELs and Microbunched beams. The emittance related topics of this list are reviewed in this report. The accelerator physics basis, the optics design principles that provide these phase space manipulations, and the possible applications of these gymnastics, are discussed. This fascinating new field promises to be a powerful tool of the future.

  8. Kayenta advanced series compensation operational experience

    Energy Technology Data Exchange (ETDEWEB)

    1994-01-01

    The world's first three-phase, thyristor-controlled series compensation scheme with continuously variable impedance has been introduced into a transmission system. Energized and dedicated in September 1992, the installation was placed into commercial operation in January 1993 and has provided over one year of operating experience. This paper describes the 230 kV, 330 MVAr (60 Hz) advanced series compensation (ASC) project, located in north-eastern Arizona at Kayenta Substation on the 320 km Glen Canyon-Shiprock transmission line. The paper describes operating experiences, coordination with phase shifting transformer, phase shifter failure, platform power, system disturbances, and future plans.

  9. Celecoxib plus chemoradiotherapy for locally advanced rectal cancer: a phase II TCOG study.

    Science.gov (United States)

    Wang, Ling-Wei; Hsiao, Chin-Fu; Chen, William Tzu-Liang; Lee, Hao-Hsien; Lin, Tzu-Chen; Chen, Hung-Chang; Chen, Hong-Hwa; Chien, Chun-Ru; Lin, Tze-Yi; Liu, Tsang-Wu

    2014-05-01

    To report the results of a phase II trial combining celecoxib and preoperative chemoradiotherapy (CRT) for locally advanced rectal cancer. Patients with clinical stage II or III rectal cancer were treated with radiotherapy of 44 Gy in 22 fractions. Concurrent chemotherapy consisted of oral tegafur-uracil and folinate on days 1-30 and 38-65. Celecoxib (400 mg/day) given from days 1 to 65. Surgery was done on day 70. The expression of cyclooxygenase 2 (COX-2) in tumor tissues was evaluated microscopically as a prognostic factor. From 2008 to 2011, 53 patients completed CRT+ celecoxib therapy and 47 received radical surgery. Grade 3 diarrhea developed in 5 (9%). Grade 4 anemia was seen in 2 (4%). Pathological complete response (pCR) was seen in 6 (13%). T or N downstaging found in 38 (81%). Sphincter preservation was achieved in 77% of low-positioned tumors. Patients with tumors expressing high-level COX-2 after CRT + celecoxib treatment had inferior pelvic control (P = 0.01), disease-free survival (P = 0.04), and overall survival (P = 0.03) than those with low-level expression. Celecoxib can be safely combined with preoperative CRT for rectal cancer. More intensified adjuvant therapy may be considered for tumors expressing high-level COX-2 after CRT and surgery. © 2013 Wiley Periodicals, Inc.

  10. Innovative grinding wheel design for cost-effective machining of advanced ceramics

    Energy Technology Data Exchange (ETDEWEB)

    Licht, R.H.; Kuo, P.; Liu, S.; Murphy, D.; Picone, J.W.; Ramanath, S.

    2000-05-01

    This Final Report covers the Phase II Innovative Grinding Wheel (IGW) program in which Norton Company successfully developed a novel grinding wheel for cost-effective cylindrical grinding of advanced ceramics. In 1995, Norton Company successfully completed the 16-month Phase I technical effort to define requirements, design, develop, and evaluate a next-generation grinding wheel for cost-effective cylindrical grinding of advanced ceramics using small prototype wheels. The Phase II program was initiated to scale-up the new superabrasive wheel specification to larger diameters, 305-mm to 406-mm, required for most production grinding of cylindrical ceramic parts, and to perform in-house and independent validation grinding tests.

  11. Innovative grinding wheel design for cost-effective machining of advanced ceramics. Phase I, final report

    Energy Technology Data Exchange (ETDEWEB)

    Licht, R.H.; Ramanath, S.; Simpson, M.; Lilley, E.

    1996-02-01

    Norton Company successfully completed the 16-month Phase I technical effort to define requirements, design, develop, and evaluate a next-generation grinding wheel for cost-effective cylindrical grinding of advanced ceramics. This program was a cooperative effort involving three Norton groups representing a superabrasive grinding wheel manufacturer, a diamond film manufacturing division and a ceramic research center. The program was divided into two technical tasks, Task 1, Analysis of Required Grinding Wheel Characteristics, and Task 2, Design and Prototype Development. In Task 1 we performed a parallel path approach with Superabrasive metal-bond development and the higher technical risk, CVD diamond wheel development. For the Superabrasive approach, Task 1 included bond wear and strength tests to engineer bond-wear characteristics. This task culminated in a small-wheel screening test plunge grinding sialon disks. In Task 2, an improved Superabrasive metal-bond specification for low-cost machining of ceramics in external cylindrical grinding mode was identified. The experimental wheel successfully ground three types of advanced ceramics without the need for wheel dressing. The spindle power consumed by this wheel during test grinding of NC-520 sialon is as much as to 30% lower compared to a standard resin bonded wheel with 100 diamond concentration. The wheel wear with this improved metal bond was an order of magnitude lower than the resin-bonded wheel, which would significantly reduce ceramic grinding costs through fewer wheel changes for retruing and replacements. Evaluation of ceramic specimens from both Tasks 1 and 2 tests for all three ceramic materials did not show evidence of unusual grinding damage. The novel CVD-diamond-wheel approach was incorporated in this program as part of Task 1. The important factors affecting the grinding performance of diamond wheels made by CVD coating preforms were determined.

  12. Biomarker-Based Phase II Trial of Savolitinib in Patients With Advanced Papillary Renal Cell Cancer.

    Science.gov (United States)

    Choueiri, Toni K; Plimack, Elizabeth; Arkenau, Hendrik-Tobias; Jonasch, Eric; Heng, Daniel Y C; Powles, Thomas; Frigault, Melanie M; Clark, Edwin A; Handzel, Amir A; Gardner, Humphrey; Morgan, Shethah; Albiges, Laurence; Pal, Sumanta Kumar

    2017-09-10

    Purpose Patients with advanced papillary renal cell carcinoma (PRCC) have limited therapeutic options. PRCC may involve activation of the MET pathway, for example, through gene amplification or mutations. Savolitinib (AZD6094, HMPL-504, volitinib) is a highly selective MET tyrosine kinase inhibitor. We report results of a single-arm, multicenter, phase II study evaluating the safety and efficacy of savolitinib in patients with PRCC according to MET status. Patients and Methods Patients with histologically confirmed locally advanced or metastatic PRCC were enrolled and received savolitinib 600 mg orally once daily. MET-driven PRCC was defined as any of the following: chromosome 7 copy gain, focal MET or HGF gene amplification, or MET kinase domain mutations. Efficacy was assessed according to MET status. Safety, toxicity, and patient-reported health-related quality-of-life outcomes were assessed in all patients. Results Of 109 patients treated, PRCC was MET driven in 44 (40%) and MET independent in 46 (42%); MET status was unknown in 19 (17%). MET-driven PRCC was strongly associated with response; there were eight confirmed partial responders with MET-driven disease (18%), but none with MET-independent disease ( P = .002). Median progression-free survival for patients with MET-driven and MET-independent PRCC was 6.2 months (95% CI, 4.1 to 7.0 months) and 1.4 months (95% CI, 1.4 to 2.7 months), respectively (hazard ratio, 0.33; 95% CI, 0.20 to 0.52; log-rank P < .001). The most frequent adverse events associated with savolitinib were nausea, fatigue, vomiting, and peripheral edema. Conclusion These data show activity and tolerability of savolitinib in the subgroup of patients with MET-driven PRCC. Furthermore, molecular characterization of MET status was more predictive of response to savolitinib than a classification based on pathology. These findings justify investigating savolitinib in MET-driven PRCC.

  13. Paired Phase II Studies of Erlotinib/Bevacizumab for Advanced Bronchioloalveolar Carcinoma or Never Smokers With Advanced Non-Small-cell Lung Cancer: SWOG S0635 and S0636 Trials.

    Science.gov (United States)

    West, Howard L; Moon, James; Wozniak, Antoinette J; Mack, Philip; Hirsch, Fred R; Bury, Martin J; Kwong, Myron; Nguyen, Dorothy D; Moore, Dennis F; Miao, Jieling; Redman, Mary; Kelly, Karen; Gandara, David R

    2018-01-01

    Before mutation testing of the epidermal growth factor receptor (EGFR) gene was recognized as highly associated with the activity of EGFR tyrosine kinase inhibitors (TKIs), clinically defined patient populations with bronchioloalveolar carcinoma (BAC) and never smokers were identified as likely to benefit from EGFR TKIs. From preclinical and clinical data suggesting potentially improved efficacy with a combination of an EGFR TKI and the antiangiogenic agent bevacizumab, the Southwestern Oncology Group (SWOG) initiated paired phase II trials to evaluate the combination of erlotinib/bevacizumab in patients with advanced BAC (SWOG S0635) or never smokers with advanced lung adenocarcinoma (SWOG S0636). Eligible patients with BAC or adenocarcinoma with BAC features (SWOG S0635) or never smokers with advanced lung adenocarcinoma (SWOG S0636) received erlotinib 150 mg/day with bevacizumab 15 mg/kg until progression or prohibitive toxicity. Never smokers with BAC were preferentially enrolled to SWOG S0636. The primary endpoint for both trials was overall survival. A total of 84 patients were enrolled in the SWOG S0635 trial and 85 in the SWOG S0636 trial. The objective response rate was 22% (3% complete response) in the SWOG S0635 trial and 50% (38% confirmed; 3% complete response) in the SWOG S0636 trial. The median progression-free survival was 5 and 7.4 months in the S0635 and S0636 trials, respectively. The median overall survival was 21 and 29.8 months, respectively. Toxicity consisted mainly of rash and diarrhea in both trials. Although the field has moved toward molecular, rather than clinical, selection of patients as optimal candidates for EGFR TKI therapy, these results support the hypothesis that a subset of patients in whom erlotinib is particularly active could receive an incremental benefit from the addition of bevacizumab. Copyright © 2017 Elsevier Inc. All rights reserved.

  14. Development of high $\\beta^*$-optics for ALICE

    CERN Document Server

    Hermes, Pascal Dominik; Wessels, Johannes Peter

    This thesis describes a feasibility study for a special optical configuration in Insertion Region 2 (IR2) of the Large Hadron Collider (LHC), which is host of the ALICE detector. This configuration allows the study of elastic and diffractive scattering during LHC high-intensity proton operation, in parallel to the nominal physics studies in all LHC experiments at the design energy of 7 TeV per beam. Such measurements require the instal- lation of additional Roman Pot (RP) detectors in the very forward region, at longitudinal distances of 150 m to 220 m from the Interaction Point (IP). Apart from being adjusted for a specific betatron phase advance between the IP and the RP detectors, such a configuration must be optimized for the largest possible $\\beta^*$ -value, to be sensitive for the smallest possible four-momentum transfer $|t|$. A value of $\\beta^*$ = 18 m is compatible with a bunch spacing of 25 ns, considering the LHC design emittance of N = 3.75 μm rad, and a required bunch-bunch separation of $12 \\...

  15. Ions in the linacs of future linear colliders

    International Nuclear Information System (INIS)

    Raubenheimer, T.O.; Chen, P.

    1992-01-01

    Ions have been identified as a potential limitation in high current storage rings. In this paper we consider the effects of ions in the linacs of future linear colliders. Future linear collider designs call for long trains of closely spaced bunches and/or very dense bunches. Significant ion densities can be generated through the collisional ionization process and trapping in a long train of bunches or through tunneling ionization with very dense bunches. These ions provide skew fields which cause transverse betatron coupling and increase the vertical emittance of the flat beams, and they increase the rate of filamentation, making correction of the emittance dilutions more difficult. While transverse coupling can be alleviated by separating the horizontal and vertical phase advances, the increased filamentation will reduce the effectiveness of non-local correction techniques, leading to tighter alignment tolerances. To reduce the effect of the ions in the designs considered to the level of the intrinsic energy spread one would need to achieve vacuum pressures less than 10 -9 Torr. 5 figs., 5 refs

  16. Effects of the beam loading in the rf deflectors of the CLIC test facility CTF3 combiner ring

    Directory of Open Access Journals (Sweden)

    David Alesini

    2004-04-01

    Full Text Available In this paper we study the impact of the rf deflectors beam loading on the transverse beam dynamics of the CTF3 combiner ring. A general expression for the single-passage wake field is obtained. Different approximated formulas are derived applying linearization of the rf deflector dispersion curve either on a limited or an unlimited frequency range. A dedicated tracking code has been written to study the multibunch multiturn effects on the transverse beam dynamics. The numerical simulations reveal that the beam emittance growth due to the wake field in the rf deflectors is a small fraction of the design emittance if the trains are injected perfectly on axis. Nevertheless in case of injection errors the final emittance growth strongly depends on the betatron phase advance between the rf deflectors. If the finite bunch length is included in the tracking code, the scenario for the central part of the bunches does not change. However, for some particular injection errors, the tails of the bunches can increase the total transverse bunch emittances.

  17. Preoperative hyperfractionated radiotherapy for locally advanced rectal cancers: a phase I-II trial

    International Nuclear Information System (INIS)

    Allal, Abdelkarim S.; Bieri, Sabine; Bruendler, Marie-Anne; Soravia, Claudio; Gertsch, Philippe; Bernier, Jacques; Morel, Philippe; Roth, Arnaud D.

    2002-01-01

    Purpose: To assess the toxicity, pathologic response rates, type of surgery, and oncologic results in a prospective Phase I-II trial using pure hyperfractionated radiotherapy (RT) preoperatively in locally advanced rectal cancer. Methods and Materials: Between September 1997 and April 2000, 50 patients with T3-T4 or N1 rectal cancers were treated preoperatively with 50 Gy (45 Gy to the pelvis and a 5-Gy tumor boost) in 40 fractions of 1.25 Gy during 4 weeks. The pretreatment tumor stage as determined by CT and endorectal ultrasonography (80% of patients) included 1 Stage T2 (2%), 45 T3 (90%), and 4 T4 (8%). Nodal involvement (N1) was documented in 26 patients (52%). Surgery was performed at a median interval of 45 days (range 26-114 days) after RT completion. Seventeen patients who presented with pT4 or pN1 and/or pM1 received 5-fluorouracil-based chemotherapy postoperatively. Results: All patients completed the RT schedule as planned. Severe acute toxicities included two Grade 3 skin reactions (4%) that did not require a break. The other acute toxicities were Grade 2 or less (skin, diarrhea, urinary, rectal tenesmus, and fatigue). A complete pathologic response was observed in 7 patients (14%), and microscopic residual cancer was found in 10 (20%). Of the 20 patients presenting with tumor located ≤6 cm from the anal verge, sphincter-saving surgery was performed in 14 (70%). At 3 years, the actuarial locoregional control rate was 90.5%, and the disease-free survival rate was 74.6%. At a median follow-up of 32 months, 4 patients (8%) presented with severe late complications (Grade 3-4) that might have been RT related (one rectovaginal fistula, two chronic perineal fistulas, and one bilateral ureteral stenosis). Conclusion: In locally advanced rectal cancer, preoperative hyperfractionated RT to a total dose of 50 Gy is feasible, with acceptable acute and late toxicity and an objective downstaging effect. In view of these results, this schedule might be used as a

  18. Stochastic Kuramoto oscillators with discrete phase states

    Science.gov (United States)

    Jörg, David J.

    2017-09-01

    We present a generalization of the Kuramoto phase oscillator model in which phases advance in discrete phase increments through Poisson processes, rendering both intrinsic oscillations and coupling inherently stochastic. We study the effects of phase discretization on the synchronization and precision properties of the coupled system both analytically and numerically. Remarkably, many key observables such as the steady-state synchrony and the quality of oscillations show distinct extrema while converging to the classical Kuramoto model in the limit of a continuous phase. The phase-discretized model provides a general framework for coupled oscillations in a Markov chain setting.

  19. Stochastic Kuramoto oscillators with discrete phase states.

    Science.gov (United States)

    Jörg, David J

    2017-09-01

    We present a generalization of the Kuramoto phase oscillator model in which phases advance in discrete phase increments through Poisson processes, rendering both intrinsic oscillations and coupling inherently stochastic. We study the effects of phase discretization on the synchronization and precision properties of the coupled system both analytically and numerically. Remarkably, many key observables such as the steady-state synchrony and the quality of oscillations show distinct extrema while converging to the classical Kuramoto model in the limit of a continuous phase. The phase-discretized model provides a general framework for coupled oscillations in a Markov chain setting.

  20. Microgravity two-phase flow and heat transfer

    CERN Document Server

    Gabriel, Kamiel S

    2007-01-01

    Advances in understanding the behaviour of multiphase thermal systems could lead to higher efficiency energy production systems, but such advances have been greatly hindered by the strong effect of gravitational acceleration on the flow. This book presents a coverage of various aspects of two-phase flow behaviour in the virtual absence of gravity.

  1. A nonlinear analysis of the EHF booster

    International Nuclear Information System (INIS)

    Colton, E.P.; Shi, D.

    1987-01-01

    We have analyzed particle motion at 1.2 GeV with assumption of nonlinearities arising from non-linear space charge forces and from the lattice sextupoles which are tuned to cancel the machine chromaticity. In the first case the motion is as expected and there are no problems as long as the x and y betatron tunes are separated by an integer or more. In the second case the motion is stable so long as the betatron amplitudes do not exceed values corresponding to beam normalized emittance of 100 mm-mr; when this occurs the effects of fifth-order betatron resonances are observed. 3 refs

  2. SAD phasing: History, current impact and future opportunities.

    Science.gov (United States)

    Rose, John P; Wang, Bi-Cheng

    2016-07-15

    Single wavelength anomalous diffraction (SAD) can trace its beginnings to the early 1950s. Researchers at the time recognized that SAD offers some unique features that might be advantageous for crystallographic phasing, despite the fact that at that time recording accurate SAD data was problematic. In this review we will follow the trail from those early days, highlighting key advances in the field and interpreting them in terms on how they stimulated continued phasing development that produced the theoretical foundation for the routine macromolecular structure determination by SAD today. The technological advances over the past three decades in both hardware and software, which played a significant role in making SAD phasing a 'first choice method', will also be described. Copyright © 2016 Elsevier Inc. All rights reserved.

  3. GaAs MMIC elements in phased-array antennas

    Science.gov (United States)

    Leonard, Regis F.

    1988-01-01

    Over the last six years NASA Lewis Research Center has carried out a program aimed at the development of advanced monolithic microwave integrated circuit technology, principally for use in phased-array antenna applications. Arising out of the Advanced Communications Technology Satellite (ACTS) program, the initial targets of the program were chips which operated at 30 and 20 GHz. Included in this group of activities were monolithic power modules with an output of 2 watts at GHz, variable phase shifters at both 20 and 30 GHz, low noise technology at 30 GHz, and a fully integrated (phase shifter, variable gain amplifier, power amplifier) transmit module at 20 GHz. Subsequent developments are centered on NASA mission requirements, particularly Space Station communications systems and deep space data communications.

  4. Lattice function measurement with TBT BPM data

    International Nuclear Information System (INIS)

    Yang, M.J.

    1995-06-01

    At Fermilab Main Ring some of the Beam Position Monitors (BPM) are instrumented with Turn-By-Turn (TBT) capability to record up to 1,024 consecutive turns of BPM data for each given trigger. For example, there are 9 horizontal plane and 8 vertical plane BPM's in the sector D3 and D4. The BPM data, which records the betatron oscillation, is fitted to obtain beam parameters x, x', y, y', and Δp/p, using the calculated beam line transfer matrix. The resulted TBT beam parameters (x, x') or (y, y') are fitted to ellipses to obtain the lattice function β, α, and the emittance associated with the betatron oscillation. The tune of the machine can be calculated from the phase space angles of the successive turns, in the normalized phase space. The beam parameters can also be used to extract transfer matrix to be used for local and global coupling analysis. The process of fitting the BPM data produces information that can be used to diagnose problems such as calibration, noise level and polarity. Being available at every turn and at changing beam position the information carries a lot of statistical power. Since most of the BPM's are located at high beta location only the x and y beam position information is not simultaneously available. The BPM data fitting processing essentially bridged the gap

  5. Concurrent chemoradiotherapy in locally advanced carcinoma of the uterine cervix: a phase I/II prospective study

    International Nuclear Information System (INIS)

    Kang, One Chul; Choi, Eun Kyung; Chung, Weon Kuu; Kim, Jong Hoon; Chang, Hye Sook; Kim, Yong Man; Kim, Young Tak; Nam, Joo Hyun; Mok, Jung Eun; Lee, Moo Song

    1998-01-01

    Prospective, single arm. Phase I/II clinical trial was performed to assess the efficacy and toxicity of the concurrent chemotherapy and definitive radiotherapy (RT) in patients with previously untreated locally advanced carcinoma of the uterine cervix. From May 1992 to January 1997, a total of 73 patients with advanced cervical carcinoma were entered on the protocol but 5 patients were excluded in analysis because of patients' refusal of treatment. Their ages ranged from 31 to 77 years, median 58 years. The international Federation of Gynecology and Obstetrics (FIGO) stage distribution was as follows: IIB 46, IIIA 2, IIIB 15 and IVA 5. RT consisted of external beam irradiation to 4, 140-5, 040 cGy/23-28 fractions plus high dose rate intracavitary treatments to deliver a dose of 30-35 Gy to point A in 6-7 fractions. During the intracavitary treatments parametrial boost was delivered for point B dose of 60 Gy in stage IIB and 65 Gy in stage IIIB. Two cycles of concurrent 5-fluorouracil and cisplatin (FP) chemotherapy (5-fluorouracil 1,000 mg/m 2 /day continuous infusion for 4 days, day 1-4, 29-32 and cisplatin 20 mg/m 2 /dy intravenous bolus for 3 days, day 1-3, 29-31) administered starting on day 1 of 1 of RT. The median follow-up was 24 months (range 4-68+). Sixty-four patients were evaluable for survival rate in this protocol: The 5-year actuarial and disease-free survival rate were 52% and 64%, respectively. The 5-year actuarial survival for stage IIB and II+IVA patients were 58% and 36%, respectively. The 5-year disease-free survival rate for stage IIB and III+IVA patients were 71% and 46%, respectively. Of the 68 patients evaluated for patterns of failure, overall recurrence rate was 27.9% (19/68): local failure in 5.9% (4/68), distant metastasis in 10.3% (7/68) and both in 11.8% (8/68). Of the 64 patients evaluated for response at one month after the completion of treatment, the complete response rate was 78% (50/64). Concurrent chemoradiation appear to be a

  6. Aluminum-centered tetrahedron-octahedron transition in advancing Al-Sb-Te phase change properties.

    Science.gov (United States)

    Xia, Mengjiao; Ding, Keyuan; Rao, Feng; Li, Xianbin; Wu, Liangcai; Song, Zhitang

    2015-02-24

    Group IIIA elements, Al, Ga, or In, etc., doped Sb-Te materials have proven good phase change properties, especially the superior data retention ability over popular Ge2Sb2Te5, while their phase transition mechanisms are rarely investigated. In this paper, aiming at the phase transition of Al-Sb-Te materials, we reveal a dominant rule of local structure changes around the Al atoms based on ab initio simulations and nuclear magnetic resonance evidences. By comparing the local chemical environments around Al atoms in respective amorphous and crystalline Al-Sb-Te phases, we believe that Al-centered motifs undergo reversible tetrahedron-octahedron reconfigurations in phase transition process. Such Al-centered local structure rearrangements significantly enhance thermal stability of amorphous phase compared to that of undoped Sb-Te materials, and facilitate a low-energy amorphization due to the weak links among Al-centered and Sb-centered octahedrons. Our studies may provide a useful reference to further understand the underlying physics and optimize performances of all IIIA metal doped Sb-Te phase change materials, prompting the development of NOR/NAND Flash-like phase change memory technology.

  7. Proceedings of the OECD/CSNI specialist meeting on advanced instrumentation and measurement techniques

    Energy Technology Data Exchange (ETDEWEB)

    Lehner, J [comp.

    1998-09-01

    In the last few years, tremendous advances in the local instrumentation technology for two-phase flow have been accomplished by the applications of new sensor techniques, optical or beam methods and electronic technology. The detailed measurements gave new insight to the true nature of local mechanisms of interfacial transfer between phases, interfacial structure and two-phase flow turbulent transfers. These new developments indicate that more accurate and reliable two-phase flow models can be obtained, if focused experiments are designed and performed by utilizing this advanced instrumentation. The purpose of this Specialist Meeting on Advanced Instrumentation and Measurement Techniques was to review the recent instrumentation developments and the relation between thermal-hydraulic codes and instrumentation capabilities. Four specific objectives were identified for this meeting: bring together international experts on instrumentation, experiments, and modeling; review recent developments in multiphase flow instrumentation; discuss the relation between modeling needs and instrumentation capabilities, and discuss future directions for instrumentation development, modeling, and experiments.

  8. Proceedings of the OECD/CSNI specialist meeting on advanced instrumentation and measurement techniques

    International Nuclear Information System (INIS)

    Lehner, J.

    1998-09-01

    In the last few years, tremendous advances in the local instrumentation technology for two-phase flow have been accomplished by the applications of new sensor techniques, optical or beam methods and electronic technology. The detailed measurements gave new insight to the true nature of local mechanisms of interfacial transfer between phases, interfacial structure and two-phase flow turbulent transfers. These new developments indicate that more accurate and reliable two-phase flow models can be obtained, if focused experiments are designed and performed by utilizing this advanced instrumentation. The purpose of this Specialist Meeting on Advanced Instrumentation and Measurement Techniques was to review the recent instrumentation developments and the relation between thermal-hydraulic codes and instrumentation capabilities. Four specific objectives were identified for this meeting: bring together international experts on instrumentation, experiments, and modeling; review recent developments in multiphase flow instrumentation; discuss the relation between modeling needs and instrumentation capabilities, and discuss future directions for instrumentation development, modeling, and experiments

  9. The advanced thermionics initiative...program update

    International Nuclear Information System (INIS)

    Lamp, T.R.; Donovan, B.D.

    1993-01-01

    The United States Air Force has had a long standing interest in thermionic space power dating back to the early 1960s when a heat pipe cooled thermionic converter was demonstrated through work at the predecessor to Wright Laboratory (WL). With the exception of the short hiatus in the mid-70s, Air Force thermionics work at Wright Laboratory has continued to the present time with thermionic technology programs including the burst power thermionic phase change concepts, heat pipe cooled planar diodes, and advanced in-core concept developments such as composite materials, insulators and oxygenation. The Advanced Thermionics Initiative (ATI) program was organized to integrate thermionic technology advances into a converter suitable for in-core reactor applications in the 10 to 40 kWe power range. As an advanced thermionics technology program, the charter and philosophy of the ATI program is to provide the needed advanced converter concepts in support of national thermionic space power programs

  10. Advanced computational model for three-phase slurry reactors

    International Nuclear Information System (INIS)

    Goodarz Ahmadi

    2000-11-01

    In the first year of the project, solid-fluid mixture flows in ducts and passages at different angle of orientations were analyzed. The model predictions are compared with the experimental data and good agreement was found. Progress was also made in analyzing the gravity chute flows of solid-liquid mixtures. An Eulerian-Lagrangian formulation for analyzing three-phase slurry flows in a bubble column is being developed. The approach uses an Eulerian analysis of gas liquid flows in the bubble column, and makes use of the Lagrangian particle tracking procedure to analyze the particle motions. Progress was also made in developing a rate dependent thermodynamically consistent model for multiphase slurry flows in a state of turbulent motion. The new model includes the effect of phasic interactions and leads to anisotropic effective phasic stress tensors. Progress was also made in measuring concentration and velocity of particles of different sizes near a wall in a duct flow. The formulation of a thermodynamically consistent model for chemically active multiphase solid-fluid flows in a turbulent state of motion was also initiated. The general objective of this project is to provide the needed fundamental understanding of three-phase slurry reactors in Fischer-Tropsch (F-T) liquid fuel synthesis. The other main goal is to develop a computational capability for predicting the transport and processing of three-phase coal slurries. The specific objectives are: (1) To develop a thermodynamically consistent rate-dependent anisotropic model for multiphase slurry flows with and without chemical reaction for application to coal liquefaction. Also to establish the material parameters of the model. (2) To provide experimental data for phasic fluctuation and mean velocities, as well as the solid volume fraction in the shear flow devices. (3) To develop an accurate computational capability incorporating the new rate-dependent and anisotropic model for analyzing reacting and

  11. Advanced worker protection system

    International Nuclear Information System (INIS)

    Caldwell, B.; Duncan, P.; Myers, J.

    1995-01-01

    The Department of Energy (DOE) is in the process of defining the magnitude and diversity of Decontamination and Decommissioning (D ampersand D) obligations at its numerous sites. The DOE believes that existing technologies are inadequate to solve many challenging problems such as how to decontaminate structures and equipment cost effectively, what to do with materials and wastes generated, and how to adequately protect workers and the environment. Preliminary estimates show a tremendous need for effective use of resources over a relatively long period (over 30 years). Several technologies are being investigated which can potentially reduce D ampersand D costs while providing appropriate protection to DOE workers. The DOE recognizes that traditional methods used by the EPA in hazardous waste site clean up activities are insufficient to provide the needed protection and worker productivity demanded by DOE D ampersand D programs. As a consequence, new clothing and equipment which can adequately protect workers while providing increases in worker productivity are being sought for implementation at DOE sites. This project will result in the development of an Advanced Worker Protection System (AWPS). The AWPS will be built around a life support backpack that uses liquid air to provide cooling as well as breathing gas to the worker. The backpack will be combined with advanced protective garments, advanced liquid cooling garment, respirator, communications, and support equipment to provide improved worker protection, simplified system maintenance, and dramatically improve worker productivity through longer duration work cycles. Phase I of the project has resulted in a full scale prototype Advanced Worker Protection Ensemble (AWPE, everything the worker will wear), with sub-scale support equipment, suitable for integrated testing and preliminary evaluation. Phase II will culminate in a full scale, certified, pre-production AWPS and a site demonstration

  12. Advanced worker protection system

    Energy Technology Data Exchange (ETDEWEB)

    Caldwell, B.; Duncan, P.; Myers, J.

    1995-12-01

    The Department of Energy (DOE) is in the process of defining the magnitude and diversity of Decontamination and Decommissioning (D&D) obligations at its numerous sites. The DOE believes that existing technologies are inadequate to solve many challenging problems such as how to decontaminate structures and equipment cost effectively, what to do with materials and wastes generated, and how to adequately protect workers and the environment. Preliminary estimates show a tremendous need for effective use of resources over a relatively long period (over 30 years). Several technologies are being investigated which can potentially reduce D&D costs while providing appropriate protection to DOE workers. The DOE recognizes that traditional methods used by the EPA in hazardous waste site clean up activities are insufficient to provide the needed protection and worker productivity demanded by DOE D&D programs. As a consequence, new clothing and equipment which can adequately protect workers while providing increases in worker productivity are being sought for implementation at DOE sites. This project will result in the development of an Advanced Worker Protection System (AWPS). The AWPS will be built around a life support backpack that uses liquid air to provide cooling as well as breathing gas to the worker. The backpack will be combined with advanced protective garments, advanced liquid cooling garment, respirator, communications, and support equipment to provide improved worker protection, simplified system maintenance, and dramatically improve worker productivity through longer duration work cycles. Phase I of the project has resulted in a full scale prototype Advanced Worker Protection Ensemble (AWPE, everything the worker will wear), with sub-scale support equipment, suitable for integrated testing and preliminary evaluation. Phase II will culminate in a full scale, certified, pre-production AWPS and a site demonstration.

  13. Integrated Advanced Monopropellant CMC Thruster / Thermal Stand-Off Assembly, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — High performance non-toxic monopropellants offer significant benefits relative to the current state-of-the-art. The benefits of these advanced monopropellants (AMP)...

  14. Non-Intrusive, Distributed Gas Sensing Technology for Advanced Spacesuits, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Advances in spacesuits are required to support the ISS and future human exploration. Spacesuit development and ground-based testing tasks require sensing and...

  15. Phase II study of cetuximab plus concomitant boost radiotherapy in Japanese patients with locally advanced squamous cell carcinoma of the head and neck

    International Nuclear Information System (INIS)

    Okano, Susumu; Yoshino, Takayuki; Fujii, Masato

    2013-01-01

    We investigated the tolerability of cetuximab plus radiotherapy in Japanese patients with untreated locally advanced squamous cell carcinoma of the head and neck. Patients with epidermal growth factor receptor-expressing locally advanced squamous cell carcinoma of the head and neck received cetuximab (400 mg/m 2 initial dose then 250 mg/m 2 weekly) for 7 weeks plus concomitant boost radiotherapy (weeks 2-7: once daily [1.8 Gy] for 3.6 weeks, then twice daily [1.8 Gy morning and 1.5 Gy afternoon] for 2.4 weeks). The primary endpoint was treatment completion rate (the rate of treated patients completing ≥70% of the planned cetuximab dose and the full dose of radiotherapy within 2 weeks over the planned schedule). Twenty-two patients were evaluable. The treatment completion rate was 100% (95% confidence interval 85-100). The response rate 8 weeks post-radiotherapy was 82% (95% confidence interval 60-95). The most common grade 3/4 treatment-emergent adverse events were mucosal inflammation (73%); dermatitis (27%); and infection, radiation skin injury and stomatitis (23% each). Cetuximab plus concomitant boost radiotherapy can be safely administered to Japanese patients with locally advanced squamous cell carcinoma of the head and neck. Tolerability and efficacy were in line with those reported in the Phase III Bonner trial in a Western population of patients with locally advanced squamous cell carcinoma of the head and neck. (author)

  16. Advanced Cathode Material For High Energy Density Lithium-Batteries, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Advanced cathode materials having high red-ox potential and high specific capacity offer great promise to the development of high energy density lithium-based...

  17. Advanced Solid-State Joining Processes for 2219 Aluminum Alloys, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Thermal Stir Welding (TSW) advances the more conventional Friction Stir Welding (C-FSW) process by separating the primary process variables of metal stirring and...

  18. Results of the Workshop on Two-Phase Flow, Fluid Stability and Dynamics: Issues in Power, Propulsion, and Advanced Life Support Systems

    Science.gov (United States)

    McQuillen, John; Rame, Enrique; Kassemi, Mohammad; Singh, Bhim; Motil, Brian

    2003-01-01

    The Two-phase Flow, Fluid Stability and Dynamics Workshop was held on May 15, 2003 in Cleveland, Ohio to define a coherent scientific research plan and roadmap that addresses the multiphase fluid problems associated with NASA s technology development program. The workshop participants, from academia, industry and government, prioritized various multiphase issues and generated a research plan and roadmap to resolve them. This report presents a prioritization of the various multiphase flow and fluid stability phenomena related primarily to power, propulsion, fluid and thermal management and advanced life support; and a plan to address these issues in a logical and timely fashion using analysis, ground-based and space-flight experiments.

  19. A phase I study of vorinostat in combination with bortezomib in patients with advanced malignancies.

    Science.gov (United States)

    Schelman, William R; Traynor, Anne M; Holen, Kyle D; Kolesar, Jill M; Attia, Steven; Hoang, Tien; Eickhoff, Jens; Jiang, Zhisheng; Alberti, Dona; Marnocha, Rebecca; Reid, Joel M; Ames, Matthew M; McGovern, Renee M; Espinoza-Delgado, Igor; Wright, John J; Wilding, George; Bailey, Howard H

    2013-12-01

    A phase I study to assess the maximum-tolerated dose (MTD), dose-limiting toxicity (DLT), pharmacokinetics (PK) and antitumor activity of vorinostat in combination with bortezomib in patients with advanced solid tumors. Patients received vorinostat orally once daily on days 1-14 and bortezomib intravenously on days 1, 4, 8 and 11 of a 21-day cycle. Starting dose (level 1) was vorinostat (400 mg) and bortezomib (0.7 mg/m(2)). Bortezomib dosing was increased using a standard phase I dose-escalation schema. PKs were evaluated during cycle 1. Twenty-three patients received 57 cycles of treatment on four dose levels ranging from bortezomib 0.7 mg/m(2) to 1.5 mg/m(2). The MTD was established at vorinostat 400 mg daily and bortezomib 1.3 mg/m(2). DLTs consisted of grade 3 fatigue in three patients (1 mg/m(2),1.3 mg/m(2) and 1.5 mg/m(2)) and grade 3 hyponatremia in one patient (1.5 mg/m(2)). The most common grade 1/2 toxicities included nausea (60.9%), fatigue (34.8%), diaphoresis (34.8%), anorexia (30.4%) and constipation (26.1%). Objective partial responses were observed in one patient with NSCLC and in one patient with treatment-refractory soft tissue sarcoma. Bortezomib did not affect the PKs of vorinostat; however, the Cmax and AUC of the acid metabolite were significantly increased on day 2 compared with day 1. This combination was generally well-tolerated at doses that achieved clinical benefit. The MTD was established at vorinostat 400 mg daily × 14 days and bortezomib 1.3 mg/m(2) on days 1, 4, 8 and 11 of a 21-day cycle.

  20. Biotemplated Nano-Structured Materials for Advanced Li-ion Batteries, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — NASA has identified a critical need for pioneering advances in battery technology to give high performance, low-weight, durable and long-life power sources for...

  1. Use of regularization method in the determination of ring parameters and orbit correction

    International Nuclear Information System (INIS)

    Tang, Y.N.; Krinsky, S.

    1993-01-01

    We discuss applying the regularization method of Tikhonov to the solution of inverse problems arising in accelerator operations. This approach has been successfully used for orbit correction on the NSLS storage rings, and is presently being applied to the determination of betatron functions and phases from the measured response matrix. The inverse problem of differential equation often leads to a set of integral equations of the first kind which are ill-conditioned. The regularization method is used to combat the ill-posedness

  2. Nonlinear Theory of Nonparaxial Laser Pulse Propagation in Plasma Channels

    International Nuclear Information System (INIS)

    Esarey, E.; Schroeder, C. B.; Shadwick, B. A.; Wurtele, J. S.; Leemans, W. P.

    2000-01-01

    Nonparaxial propagation of ultrashort, high-power laser pulses in plasma channels is examined. In the adiabatic limit, pulse energy conservation, nonlinear group velocity, damped betatron oscillations, self-steepening, self-phase modulation, and shock formation are analyzed. In the nonadiabatic limit, the coupling of forward Raman scattering (FRS) and the self-modulation instability (SMI) is analyzed and growth rates are derived, including regimes of reduced growth. The SMI is found to dominate FRS in most regimes of interest. (c) 2000 The American Physical Society

  3. Performance evaluation of a full-scale advanced phase isolation ditch process by using real-time control strategies

    International Nuclear Information System (INIS)

    Kim, Hyosoo; Kim, Yejin; Kim, Minsoo; Piao, Wenhua; Kim, Changwon; Gee, Jeasung

    2014-01-01

    This paper proposes real-time control strategies that can be applied in a full-scale advanced phase isolation ditch (APID) process. Real-time operation mode control (OMC) and aeration section control (ASC) strategies were developed to cope more stably with fluctuations in the influent loading and to increase the nitrification and denitrification reactions within the entire volume. The real-time OMC and ASC strategies were evaluated using mathematical models. When the NH 4 -N in the reactor was maintained at a high level, appropriate control actions, such as continuing the aeration state, stopping the influent inflow and increasing the aeration section, were applied in the APID process. In contrast, when the NO X -N in the reactor was maintained at a high level, the non-aeration state, influent inflow, and decreased aeration section were continued. It was concluded that stable operation in the APID process could be achieved by applying real-time OMC and ASC strategies developed in this study

  4. Performance evaluation of a full-scale advanced phase isolation ditch process by using real-time control strategies

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyosoo; Kim, Yejin; Kim, Minsoo; Piao, Wenhua; Kim, Changwon [Pusan National University, Busan (Korea, Republic of); Gee, Jeasung [Taiwha Industrial Co. Ltd., Seoul (Korea, Republic of)

    2014-04-15

    This paper proposes real-time control strategies that can be applied in a full-scale advanced phase isolation ditch (APID) process. Real-time operation mode control (OMC) and aeration section control (ASC) strategies were developed to cope more stably with fluctuations in the influent loading and to increase the nitrification and denitrification reactions within the entire volume. The real-time OMC and ASC strategies were evaluated using mathematical models. When the NH{sub 4}-N in the reactor was maintained at a high level, appropriate control actions, such as continuing the aeration state, stopping the influent inflow and increasing the aeration section, were applied in the APID process. In contrast, when the NO{sub X}-N in the reactor was maintained at a high level, the non-aeration state, influent inflow, and decreased aeration section were continued. It was concluded that stable operation in the APID process could be achieved by applying real-time OMC and ASC strategies developed in this study.

  5. Limitations of the Conventional Phase Advance Method for Constant Power Operation of the Brushless DC Motor

    International Nuclear Information System (INIS)

    Lawler, J.S.

    2001-01-01

    The brushless dc motor (BDCM) has high-power density and efficiency relative to other motor types. These properties make the BDCM well suited for applications in electric vehicles provided a method can be developed for driving the motor over the 4 to 6:1 constant power speed range (CPSR) required by such applications. The present state of the art for constant power operation of the BDCM is conventional phase advance (CPA)[1]. In this paper, we identify key limitations of CPA. It is shown that the CPA has effective control over the developed power but that the current magnitude is relatively insensitive to power output and is inversely proportional to motor inductance. If the motor inductance is low, then the rms current at rated power and high speed may be several times larger than the current rating. The inductance required to maintain rms current within rating is derived analytically and is found to be large relative to that of BDCM designs using high-strength rare earth magnets. Th us, the CPA requires a BDCM with a large equivalent inductance

  6. Deep UV Semiconductor Sources for Advanced Planetary Science Instruments, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — This proposal addresses the need for miniature, narrow-linewidth, deep UV optical sources that operate at very low ambient temperatures for use in advanced in situ...

  7. Advanced Optical Metrology for XRAY Replication Mandrels and Mirrors, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Advanced x-ray observatories such as IXO and GenX will require thousands of thin shell mirror segments produced by replication using convex mandrels. Quality and...

  8. Principle of Global Decoupling with Coupling Angle Modulation

    CERN Document Server

    Luo, Yun; Pilat, Fulvia Caterina; Roser, Thomas; Trbojevic, Dejan

    2005-01-01

    The global betatron decoupling on the ramp is an important issue for the operation of the Relativistic Heavy Ion Collider (RHIC). A new scheme coupling phase modulation is found. It introduces a rotating extra coupling into the coupled machine to detect the residual coupling. The eigentune responses are measured with a high resolution phase lock loop (PLL) system. From the minimum and maximum tune splits, the correction strengths are given. The time period occupied by one coupling phase modulation is less than 10 seconds. So it is a very promising solution for the global decoupling on the ramp. In this article the principle of the coupling phase modulation is given. The simulation with the smooth accelerator model is also done. The practical issues concerning its applications are discussed.

  9. Two-phase flow in refrigeration systems

    CERN Document Server

    Gu, Junjie; Gan, Zhongxue

    2013-01-01

    Two-Phase Flow in Refrigeration Systems presents recent developments from the authors' extensive research programs on two-phase flow in refrigeration systems. This book covers advanced mass and heat transfer and vapor compression refrigeration systems and shows how the performance of an automotive air-conditioning system is affected through results obtained experimentally and theoretically, specifically with consideration of two-phase flow and oil concentration. The book is ideal for university postgraduate students as a textbook, researchers and professors as an academic reference book, and b

  10. Phasing of Debuncher Stochastic Cooling Transverse Systems

    International Nuclear Information System (INIS)

    Pasquinelli, Ralph

    2000-01-01

    With the higher frequency of the cooling systems in the Debuncher, a modified method of making transfer functions has been developed for transverse systems. (Measuring of the momentum systems is unchanged.) Speed in making the measurements is critical, as the beam tends to decelerate due to vacuum lifetime. In the 4-8 GHz band, the harmonics in the Debuncher are 6,700 to 13,400 times the revolution frequency. Every Hertz change in revolution frequency is multiplied by this harmonic number and becomes a frequency measurement error, which is an appreciable percent of the momentum width of the beam. It was originally thought that a momentum cooling system would be phased first so that the beam could be kept from drifting in revolution frequency. As it turned out, the momentum cooling was so effective (even with the gain turned down) that the momentum width normalized to fo became less than one Hertz on the Schottky pickup. A beam this narrow requires very precise measurement of tune and revolution frequency. It was difficult to get repeatable results. For initial measuring of the transverse arrays, relative phase and delay is all that is required, so the measurement settings outlined below will suffice. Once all input and output arrays are phased, a more precise measurement of all pickups to all kickers can be done with more points and both upper and lower side bands, as in figure 1. Settings on the network analyzer were adjusted for maximum measurement speed. Data is not analyzed until a complete set of measurements is taken. Start and stop frequencies should be chosen to be just slightly wider than the band being measured. For transverse systems, select betatron USB for the measurement type. This will make the measurement two times faster. Select 101 for the number of points, sweep time of 5 seconds, IF bandwidth 30 Hz, averages = 1. It is important during the phasing to continually measure the revolution frequency and beam width of the beam for transverse systems

  11. Influence of vertical dispersion and crossing angle on the performance of the LHC

    CERN Document Server

    Leunissen, L H A

    1999-01-01

    Misalignments, magnetic field deviations and the beam crossing angle induce closed orbit deviations and residual dispersions at the interaction points (IPs) of the LHC. At IP1 and IP5, the horizontal and vertical dispersion functions are approximately ±2 cm while at IP2 and IP8 they can reach values up to 50 cm. A numerical study of the excitation of synchro-betatron resonances by crossing angles and dispersions shows that the beam size changes by less than 5% and has corresponding effects on the luminosity. Since the effects of bunch length are important in this context we have used the numerical code BBC for the study. When the betatron tunes are close to a synchro-betatron resonance excited by the crossing angle the amplitude of particle oscillations increases. The superposition of vertical dispersion modifies the strength of the resonance. For example, sidebands of the resonance 13Qx = 4 yield an increase of the amplitude of the betatron oscillation by less than 10 % at an initial amplitude of 5s. Includ...

  12. Space Station Validation of Advanced Radiation-Shielding Polymeric Materials, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — In Subtopic X11.01, NASA has identified the need to develop advanced radiation-shielding materials and systems to protect humans from the hazards of space radiation...

  13. Brain-wave measures of workload in advanced cockpits: The transition of technology from laboratory to cockpit simulator, phase 2

    Science.gov (United States)

    Horst, Richard L.; Mahaffey, David L.; Munson, Robert C.

    1989-01-01

    The present Phase 2 small business innovation research study was designed to address issues related to scalp-recorded event-related potential (ERP) indices of mental workload and to transition this technology from the laboratory to cockpit simulator environments for use as a systems engineering tool. The project involved five main tasks: (1) Two laboratory studies confirmed the generality of the ERP indices of workload obtained in the Phase 1 study and revealed two additional ERP components related to workload. (2) A task analysis' of flight scenarios and pilot tasks in the Advanced Concepts Flight Simulator (ACFS) defined cockpit events (i.e., displays, messages, alarms) that would be expected to elicit ERPs related to workload. (3) Software was developed to support ERP data analysis. An existing ARD-proprietary package of ERP data analysis routines was upgraded, new graphics routines were developed to enhance interactive data analysis, and routines were developed to compare alternative single-trial analysis techniques using simulated ERP data. (4) Working in conjunction with NASA Langley research scientists and simulator engineers, preparations were made for an ACFS validation study of ERP measures of workload. (5) A design specification was developed for a general purpose, computerized, workload assessment system that can function in simulators such as the ACFS.

  14. Normal form analysis of linear beam dynamics in a coupled storage ring

    International Nuclear Information System (INIS)

    Wolski, Andrzej; Woodley, Mark D.

    2004-01-01

    The techniques of normal form analysis, well known in the literature, can be used to provide a straightforward characterization of linear betatron dynamics in a coupled lattice. Here, we consider both the beam distribution and the betatron oscillations in a storage ring. We find that the beta functions for uncoupled motion generalize in a simple way to the coupled case. Defined in the way that we propose, the beta functions remain well behaved (positive and finite) under all circumstances, and have essentially the same physical significance for the beam size and betatron oscillation amplitude as in the uncoupled case. Application of this analysis to the online modeling of the PEP-II rings is also discussed

  15. Advanced Propulsion Physics Lab: Eagleworks Investigations

    Science.gov (United States)

    Scogin, Tyler

    2014-01-01

    Eagleworks Laboratory is an advanced propulsions physics laboratory with two primary investigations currently underway. The first is a Quantum Vacuum Plasma Thruster (QVPT or Q-thrusters), an advanced electric propulsion technology in the development and demonstration phase. The second investigation is in Warp Field Interferometry (WFI). This is an investigation of Dr. Harold "Sonny" White's theoretical physics models for warp field equations using optical experiments in the Electro Optical laboratory (EOL) at Johnson Space Center. These investigations are pursuing technology necessary to enable human exploration of the solar system and beyond.

  16. Vapor Chamber with Phase Change Material-based Wick Structure for Thermal Control of Manned Spacecraft, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — In response to NASA SBIR solicitation H3.01 "Thermal Control for Future Human Exploration", Advanced Cooling Technologies, Inc. (ACT) is proposing a novel Phase...

  17. Singularity and stability in a periodic system of particle accelerators

    Science.gov (United States)

    Cai, Yunhai

    2018-05-01

    We study the single-particle dynamics in a general and parametrized alternating-gradient cell with zero chromaticity using the Lie algebra method. To our surprise, the first-order perturbation of the sextupoles largely determines the dynamics away from the major resonances. The dynamic aperture can be estimated from the topology and geometry of the phase space. In the linearly normalized phase space, it is scaled according to A ¯ ∝ϕ √{L } , where ϕ is the bending angle and L the length of the cell. For the 2 degrees of freedom with equal betatron tunes, the analytical perturbation theory leads us to the invariant or quasi-invariant tori, which play an important role in determining the stable volume in the four-dimensional phase space.

  18. Phase I/II Trial of Sequential Chemoradiotherapy Using a Novel Hypoxic Cell Radiosensitizer, Doranidazole (PR-350), in Patients With Locally Advanced Non-Small-Cell Lung Cancer (WJTOG-0002)

    International Nuclear Information System (INIS)

    Nishimura, Yasumasa; Nakagawa, Kazuhiko; Takeda, Koji; Tanaka, Masahiro; Segawa, Yoshihiko; Tsujino, Kayoko; Negoro, Shunichi; Fuwa, Nobukazu; Hida, Toyoaki; Kawahara, Masaaki; Katakami, Nobuyuki; Hirokawa, Keiko; Yamamoto, Nobuyuki; Fukuoka, Masahiro; Ariyoshi, Yutaka

    2007-01-01

    Purpose: This Phase I/II trial was conducted to assess the efficacy and safety of PR-350, a novel hypoxic cell radiosensitizer, when administered with thoracic radiation therapy (RT) after induction chemotherapy (CT) for locally advanced non-small-cell lung cancer (NSCLC). Methods and Materials: Two cycles of cisplatin (80 mg/m 2 ) and paclitaxel (180 mg/m 2 ), or carboplatin (AUC = 6) and paclitaxel (200 mg/m 2 ) were given before RT of 60 Gy in 30 fractions. In the Phase I portion, the starting dosage of PR-350 was 10 daily administrations (2000 mg/m 2 ) in combination with RT, and this number was increased in increments of 10 for successive groups to 30 doses. Results: In total, 37 patients were enrolled. In Phase I (n = 20), PR-350 could be administered 30 times with concurrent thoracic RT. Thus, in Phase II (n = 17), PR-350 was administered 30 times. The major toxicity was radiation pneumonitis, with Grade 3 or more pneumonitis noted in 6 patients (16%) including 2 with treatment-related deaths. However, no Grade 3 or more esophageal toxicity was noted, and only Grade 1 peripheral neuropathy was noted in 9 patients (24%). For all 37 patients, the median survival time (MST) and the 2-year survival rate were 15.9 months and 24%, respectively. For 18 patients receiving 21 to 30 doses of PR-350, the MST and 2-year survival rate were 20.9 months and 33%, respectively. Conclusions: Thoracic RT combined with 30 daily administrations of PR-350 after induction CT was well tolerated and promising for locally advanced NSCLC

  19. Experimental facility with two-phase flow and with high concentration of non-condensable gases for research and development of emergency cooling system of advanced nuclear reactors

    International Nuclear Information System (INIS)

    Macedo, Luiz Alberto; Baptista Filho, Benedito Dias

    2006-01-01

    The development of emergency cooling passive systems of advanced nuclear reactors requires the research of some relative processes to natural circulation, in two-phase flow conditions involving condensation processes in the presence of non-condensable gases. This work describes the main characteristics of the experimental facility called Bancada de Circulacao Natural (BCN), designed for natural circulation experiments in a system with a hot source, electric heater, a cold source, heat exchanger, operating with two-phase flow and with high concentration of noncondensable gas, air. The operational tests, the data acquisition system and the first experimental results in natural circulation are presented. The experiments are transitory in natural circulation considering power steps. The distribution of temperatures and the behavior of the flow and of the pressure are analyzed. The experimental facility, the instrumentation and the data acquisition system demonstrated to be adapted for the purposes of research of emergency cooling passive systems, operating with two-phase flow and with high concentration of noncondensable gases. (author)

  20. Nonlinear dynamics in Nuclotron

    International Nuclear Information System (INIS)

    Dinev, D.

    1997-01-01

    The paper represents an extensive study of the nonlinear beam dynamics in the Nuclotron. Chromatic effects, including the dependence of the betatron tunes on the amplitude, and chromatic perturbations have been investigated taking into account the measured field imperfections. Beam distortion, smear, dynamic aperture and nonlinear acceptance have been calculated for different particle energies and betatron tunes

  1. Evaluation of Erosion Resistance of Advanced Turbine Thermal Barrier Coatings

    Science.gov (United States)

    Zhu, Dongming; Kuczmarski, Maria A.; Miller, Robert A.; Cuy, Michael D.

    2007-01-01

    The erosion resistant turbine thermal barrier coating system is critical to aircraft engine performance and durability. By demonstrating advanced turbine material testing capabilities, we will be able to facilitate the critical turbine coating and subcomponent development and help establish advanced erosion-resistant turbine airfoil thermal barrier coatings design tools. The objective of this work is to determine erosion resistance of advanced thermal barrier coating systems under simulated engine erosion and/or thermal gradient environments, validating advanced turbine airfoil thermal barrier coating systems based on nano-tetragonal phase toughening design approaches.

  2. Phase III randomized trial comparing 5-fluorouracil and oxaliplatin with or without docetaxel in first-line advanced gastric cancer chemotherapy (GASTFOX study).

    Science.gov (United States)

    Zaanan, Aziz; Samalin, Emmanuelle; Aparicio, Thomas; Bouche, Olivier; Laurent-Puig, Pierre; Manfredi, Sylvain; Michel, Pierre; Monterymard, Carole; Moreau, Marie; Rougier, Philippe; Tougeron, David; Taieb, Julien; Louvet, Christophe

    2018-04-01

    In advanced gastric cancer, doublet regimen including platinum salts and fluoropyrimidine is considered as a standard first-line treatment. The addition of docetaxel (75 mg/m 2  q3w) to cisplatin (75 mg/m 2  q3w) and 5-fluorouracil has been shown to improve efficacy. However, this regimen (DCF) was associated with frequent severe toxicities (including more complicated neutropenia), limiting its use in clinical practice. Interesting alternative docetaxel-based regimens have been developed that need to be validated. GASTFOX study is a randomized phase III trial comparing FOLFOX alone or with docetaxel at 50 mg/m 2 (TFOX regimen) in first-line treatment for advanced gastric cancer. In both arms, cycle is repeated every 2 weeks until disease progression or unacceptable toxicity. Main eligibility criteria: histologically proven locally advanced or metastatic gastric or esogastric junction adenocarcinoma, HER negative status, measurable disease, ECOG performance status 0 or 1, and adequate renal, hepatic and bone marrow functions. The primary endpoint is radiological/clinical progression-free survival (PFS). A difference of 2 months for the median PFS in favor of TFOX is expected (HR = 0.73) Based on a two-sided α risk of 5% and a power of 90%, 454 events are required to show this difference. Secondary endpoints included overall survival, overall response rate, safety, quality of life and the therapeutic index. This study is planned to include 506 patients to demonstrate the superiority of TFOX over FOLFOX in first-line advanced gastric cancer treatment (NCT03006432). Copyright © 2018 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

  3. A Nanodroplet Processor for Advanced Microencapsulated Drug Formulations, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — During this Phase II program we propose to build on the key aspects of the nanodroplet encapsulation technology to demonstrate optimized formulation and...

  4. Results of a phase I dose escalation study of eltrombopag in patients with advanced soft tissue sarcoma receiving doxorubicin and ifosfamide

    International Nuclear Information System (INIS)

    Chawla, Sant P; Staddon, Arthur; Hendifar, Andrew; Messam, Conrad A; Patwardhan, Rita; Kamel, Yasser Mostafa

    2013-01-01

    The objective of this Phase I dose escalation study was to explore the safety and tolerability of eltrombopag, an oral, nonpeptide, thrombopoietin receptor agonist, in patients with advanced soft tissue sarcoma (STS) and thrombocytopenia due to treatment with doxorubicin and ifosfamide (AI) combination chemotherapy. Patients aged 18 or older with histologically confirmed, locally advanced or metastatic STS were treated with 1 cycle of AI followed by AI with eltrombopag starting at Cycle 2, using 2 different dosing schedules. The study design included an eltrombopag dose escalation phase starting at 75 mg daily to determine the optimal biological dose (OBD). Eighteen patients were enrolled and 15 received at least 1 dose of chemotherapy; 3 patients withdrew prior to receiving eltrombopag. Seven, 4, and 1 patients received 75 mg, 100 mg, and 150 mg eltrombopag daily, respectively. No dose-limiting toxicities were reported. Due to slow recruitment, the study was closed prior to identifying an OBD. The most common hematologic adverse events (AEs) were thrombocytopenia (80%), neutropenia (73%), and anemia (67%). The most common nonhematologic AEs were fatigue (53%), alanine aminotransferase increased, constipation, and nausea (47% each). Eleven of 12 patients who received eltrombopag completed at least 2 chemotherapy cycles; all had increased platelet counts on Day 1 of Cycle 2 (cycle with eltrombopag) compared to Day 1 of Cycle 1 (cycle without eltrombopag). Although data are limited, safety data were consistent with the known toxicities of AI combination chemotherapy or the side effect profile of eltrombopag seen in other studies. Available data suggest a potential pre- and post-chemotherapy dosing scheme for eltrombopag when administered with AI chemotherapy, and support further investigation of eltrombopag treatment in patients with chemotherapy-induced thrombocytopenia

  5. Advanced supersonic propulsion study, phases 3 and 4. [variable cycle engines

    Science.gov (United States)

    Allan, R. D.; Joy, W.

    1977-01-01

    An evaluation of various advanced propulsion concepts for supersonic cruise aircraft resulted in the identification of the double-bypass variable cycle engine as the most promising concept. This engine design utilizes special variable geometry components and an annular exhaust nozzle to provide high take-off thrust and low jet noise. The engine also provides good performance at both supersonic cruise and subsonic cruise. Emission characteristics are excellent. The advanced technology double-bypass variable cycle engine offers an improvement in aircraft range performance relative to earlier supersonic jet engine designs and yet at a lower level of engine noise. Research and technology programs required in certain design areas for this engine concept to realize its potential benefits include refined parametric analysis of selected variable cycle engines, screening of additional unconventional concepts, and engine preliminary design studies. Required critical technology programs are summarized.

  6. A phase II study of concomitant boost radiation plus concurrent weekly cisplatin for locally advanced unresectable head and neck carcinomas

    International Nuclear Information System (INIS)

    Medina, Jose Antonio; Rueda, Antonio; Sacchetti de Pasos, Antonio; Contreras, Jorge; Cobo, Manuel; Moreno, Paloma; Benavides, Manuel; Villanueva, Asuncion; Alba, Emilio

    2006-01-01

    Background and purpose: This phase II study evaluated the efficacy and toxicity of weekly cisplatin along with concomitant boost accelerated radiation regimen in patients with locally advanced unresectable head and neck carcinoma. Material and methods: A total of 94 patients (median age, 58 years) with UICC stage III (n=19) and IV (n=75) cancer of the oropharynx, larynx, hypopharynx and oral cavity were included. Patients received radiotherapy with a concomitant boost scheme (1.8 Gy on days 1-40 and 1.5 Gy boost on days 25-40 with a total dose of 72 Gy) and concurrent cisplatin, 40 mg/m 2 weekly, for the first 4 weeks. Results: Most patients (95%) received both radiation and chemotherapy according to protocol. Toxicity was manageable with grade III mucositis and pharyngeal-oesophageal toxicity in 85 and 50% of patients, respectively. Haematological toxicity was mild. Four patients (4%) died due to complications. With a median follow of 41 months, median overall survival and time to progression were 27 and 25 months, respectively. The estimated overall survival at 4 years was 41%. Conclusions: Concomitant boost accelerated radiation plus concurrent weekly cisplatin is a feasible schedule in patients with locally advanced unresectable head and neck carcinoma, with acceptable toxicity and survival data

  7. Advanced steel reheat furnace

    Energy Technology Data Exchange (ETDEWEB)

    Moyeda, D.; Sheldon, M.; Koppang, R. [Energy and Environmental Research Corp., Irvine, CA (United States); Lanyi, M.; Li, X.; Eleazer, B. [Air Products and Chemicals, Inc., Allentown, PA (United States)

    1997-10-01

    Energy and Environmental Research Corp. (EER) under a contract from the Department of Energy is pursuing the development and demonstration of an Advanced Steel Reheating Furnace. This paper reports the results of Phase 1, Research, which has evaluated an advanced furnace concept incorporating two proven and commercialized technologies previously applied to other high temperature combustion applications: EER`s gas reburn technology (GR) for post combustion NOx control; and Air Product`s oxy-fuel enrichment air (OEA) for improved flame heat transfer in the heating zones of the furnace. The combined technologies feature greater production throughput with associated furnace efficiency improvements; lowered NOx emissions; and better control over the furnace atmosphere, whether oxidizing or reducing, leading to better control over surface finish.

  8. Reversible switching in phase-change materials

    OpenAIRE

    Wojciech Wełnic; Matthias Wuttig

    2008-01-01

    Phase-change materials are successfully employed in optical data storage and are becoming a promising candidate for future electronic storage applications. Despite the increasing technological interest, many fundamental properties of these materials remain poorly understood. However, in the last few years the understanding of the material properties of phase-change materials has increased significantly. At the same time, great advances have been achieved in technological applications in elect...

  9. Crizotinib for Advanced Non-Small Cell Lung Cancer

    Science.gov (United States)

    A summary of results from an international phase III clinical trial that compared crizotinib versus chemotherapy in previously treated patients with advanced lung cancer whose tumors have an EML4-ALK fusion gene.

  10. Structure of Partially Premixed Flames and Advanced Solid Propellants

    National Research Council Canada - National Science Library

    Branch, Melvyn

    1998-01-01

    The combustion of solid rocket propellants of advanced energetic materials involves a complex process of decomposition and condensed phase reactions in the solid propellant, gaseous flame reactions...

  11. Utility advanced turbine systems (ATS) technology readiness testing

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-09-15

    The overall objective of the Advanced Turbine System (ATS) Phase 3 Cooperative Agreement between GE and the US Department of Energy (DOE) is the development of a highly efficient, environmentally superior, and cost-competitive utility ATS for base-load utility-scale power generation, the GE 7H (60 Hz) combined cycle power system, and related 9H (50 Hz) common technology. The major effort will be expended on detail design. Validation of critical components and technologies will be performed, including: hot gas path component testing, sub-scale compressor testing, steam purity test trials, and rotational heat transfer confirmation testing. Processes will be developed to support the manufacture of the first system, which was to have been sited and operated in Phase 4 but will now be sited and operated commercially by GE. This change has resulted from DOE's request to GE for deletion of Phase 4 in favor of a restructured Phase 3 (as Phase 3R) to include full speed, no load (FSNL) testing of the 7H gas turbine. Technology enhancements that are not required for the first machine design but will be critical for future ATS advances in performance, reliability, and costs will be initiated. Long-term tests of materials to confirm design life predictions will continue. A schematic of the GE H machine is shown.

  12. Phase I clinical trial of fibronectin CH296-stimulated T cell therapy in patients with advanced cancer.

    Directory of Open Access Journals (Sweden)

    Takeshi Ishikawa

    Full Text Available BACKGROUND: Previous studies have demonstrated that less-differentiated T cells are ideal for adoptive T cell transfer therapy (ACT and that fibronectin CH296 (FN-CH296 together with anti-CD3 resulted in cultured cells that contain higher amounts of less-differentiated T cells. In this phase I clinical trial, we build on these prior results by assessing the safety and efficacy of FN-CH296 stimulated T cell therapy in patients with advanced cancer. METHODS: Patients underwent fibronectin CH296-stimulated T cell therapy up to six times every two weeks and the safety and antitumor activity of the ACT were assessed. In order to determine immune function, whole blood cytokine levels and the number of peripheral regulatory T cells were analyzed prior to ACT and during the follow up. RESULTS: Transferred cells contained numerous less-differentiated T cells greatly represented by CD27+CD45RA+ or CD28+CD45RA+ cell, which accounted for approximately 65% and 70% of the total, respectively. No ACT related severe or unexpected toxicities were observed. The response rate among patients was 22.2% and the disease control rate was 66.7%. CONCLUSIONS: The results obtained in this phase I trial, indicate that FN-CH296 stimulated T cell therapy was very well tolerated with a level of efficacy that is quite promising. We also surmise that expanding T cell using CH296 is a method that can be applied to other T- cell-based therapies. TRIAL REGISTRATION: UMIN UMIN000001835.

  13. Microcanonical rates, gap times, and phase space dividing surfaces

    NARCIS (Netherlands)

    Ezra, Gregory S.; Waalkens, Holger; Wiggins, Stephen

    2009-01-01

    The general approach to classical unimolecular reaction rates due to Thiele is revisited in light of recent advances in the phase space formulation of transition state theory for multidimensional systems. Key concepts, such as the phase space dividing surface separating reactants from products, the

  14. Chromaticity correction in the TRISTAN phase I main ring with two types of insertion

    International Nuclear Information System (INIS)

    Wu, Yingzhi; Egawa, Kazumi.

    1984-07-01

    The TRISTAN main ring now under construction has four insertions. Besides the normal modes in which the four insertions have the same optics, the TRISTAN main ring will be operated in somewhat more complicated configurations with insertions having different optics. This report will consider chromaticity corrections using six families of sextupoles for the TRISTAN main ring with two different insertion types; opposite insertions have the same optics. The strength of correcting sextupoles is determined mainly using the W-correction method. The program PATRICIA is used to track the trajectories of test particles over 800 turns. The results show that the correction scheme adopted allows adequately large amplitudes of betatron and synchrotron oscillations. (author)

  15. Advanced Virgo: a second-generation interferometric gravitational wave detector

    International Nuclear Information System (INIS)

    Acernese, F; Barone, F; Agathos, M; Agatsuma, K; Bauer, Th S; Beker, M G; Aisa, D; Allemandou, N; Allocca, A; Amarni, J; Baronick, J-P; Barsuglia, M; Astone, P; Basti, F; Balestri, G; Ballardin, G; Bavigadda, V; Basti, A; Bejger, M; Belczynski, C

    2015-01-01

    Advanced Virgo is the project to upgrade the Virgo interferometric detector of gravitational waves, with the aim of increasing the number of observable galaxies (and thus the detection rate) by three orders of magnitude. The project is now in an advanced construction phase and the assembly and integration will be completed by the end of 2015. Advanced Virgo will be part of a network, alongside the two Advanced LIGO detectors in the US and GEO HF in Germany, with the goal of contributing to the early detection of gravitational waves and to opening a new window of observation on the universe. In this paper we describe the main features of the Advanced Virgo detector and outline the status of the construction. (paper)

  16. Laser wakefield accelerator based light sources: potential applications and requirements

    Energy Technology Data Exchange (ETDEWEB)

    Albert, F. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). NIF and Photon Sciences; Thomas, A. G. [Univ. of Michigan, Ann Arbor, MI (United States). Dept. of Nuclear Engineering and Radiological Sciences; Mangles, S. P.D. [Imperial College, London (United Kingdom). Blackett Lab.; Banerjee, S. [Univ. of Nebraska, Lincoln, NE (United States); Corde, S. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Flacco, A. [ENSTA, CNRS, Ecole Polytechnique, Palaiseau (France); Litos, M. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Neely, D. [Science and Technology Facilities Council (STFC), Oxford (United Kingdom). Rutherford Appleton Lab. (RAL). Central Laser Facility; Viera, J. [Univ. of Lisbon (Portugal). GoLP-Inst. de Plasmas e Fusao Nuclear-Lab. Associado; Najmudin, Z. [Imperial College, London (United Kingdom). Blackett Lab.; Bingham, R. [Science and Technology Facilities Council (STFC), Oxford (United Kingdom). Rutherford Appleton Lab. (RAL). Central Laser Facility; Joshi, C. [Univ. of California, Los Angeles, CA (United States). Dept. of Electrical Engineering; Katsouleas, T. [Duke Univ., Durham, NC (United States). Platt School of Engineering

    2015-01-15

    In this article we review the prospects of laser wakefield accelerators as next generation light sources for applications. This work arose as a result of discussions held at the 2013 Laser Plasma Accelerators Workshop. X-ray phase contrast imaging, X-ray absorption spectroscopy, and nuclear resonance fluorescence are highlighted as potential applications for laser-plasma based light sources. We discuss ongoing and future efforts to improve the properties of radiation from plasma betatron emission and Compton scattering using laser wakefield accelerators for these specific applications.

  17. Research advances in regorafenib in treatment of hepatocellular carcinoma

    Directory of Open Access Journals (Sweden)

    CHEN Weibo

    2017-12-01

    Full Text Available Hepatocellular carcinoma (HCC is the most common malignant liver tumor, and there are limited systemic treatments for patients with advanced HCC. Regorafenib is an oral multi-kinase inhibitor, and phase III clinical trial has shown that regorafenib can significantly extend the median survival of patients with advanced HCC by 2.8 months, which makes it a second-line drug approved by FDA for the treatment of advanced HCC, just after sorafenib. This article reviews the basic and clinical research on regorafenib in the field of HCC.

  18. Advanced rotary engine components utilizing fiber reinforced Mg castings

    Science.gov (United States)

    Goddard, D.; Whitman, W.; Pumphrey, R.; Lee, C.-M.

    1986-01-01

    Under a two-phase program sponsored by NASA, the technology for producing advanced rotary engine components utilizing graphite fiber-reinforced magnesium alloy casting is being developed. In Phase I, the successful casting of a simulated intermediate housing was demonstrated. In Phase II, the goal is to produce an operating rotor housing. The effort involves generation of a material property data base, optimization of parameters, and development of wear- and corrosion-resistant cast surfaces and surface coatings. Results to date are described.

  19. Advanced Controller Developed for the Free-Piston Stirling Convertor

    Science.gov (United States)

    Gerber, Scott S.

    2005-01-01

    A free-piston Stirling power convertor is being considered as an advanced power-conversion technology for future NASA deep-space missions requiring long-life radioisotope power systems. The NASA Glenn Research Center has identified key areas where advanced technologies can enhance the capability of Stirling energy-conversion systems. One of these is power electronic controls. Current power-conversion technology for Glenn-tested Stirling systems consists of an engine-driven linear alternator generating an alternating-current voltage controlled by a tuning-capacitor-based alternating-current peak voltage load controller. The tuning capacitor keeps the internal alternator electromotive force (EMF) in phase with its respective current (i.e., passive power factor correction). The alternator EMF is related to the piston velocity, which must be kept in phase with the alternator current in order to achieve stable operation. This tuning capacitor, which adds volume and mass to the overall Stirling convertor, can be eliminated if the controller can actively drive the magnitude and phase of the alternator current.

  20. A Grounded Theory Approach to Physical Activity and Advanced Cancer

    Directory of Open Access Journals (Sweden)

    Sonya S. Lowe

    2015-11-01

    Full Text Available Background: Physical activity has demonstrated benefits in cancer-related fatigue and physical functioning in early-stage cancer patients, however the role of physical activity at the end stage of cancer has not been established. To challenge positivist–empiricist assumptions, I am seeking to develop a new theoretical framework that is grounded in the advanced cancer patient’s experience of activity. Aim: To gain an in-depth understanding of the experience of activity and quality of life in advanced cancer patients. Objectives: (1 To explore the meaning of activity for advanced cancer patients in the context of their day-to-day life, (2 to elicit advanced cancer patients’ perceptions of activity with respect to their quality of life, and (3 to elicit advanced cancer patients’ views of barriers and facilitators to activity in the context of their day-to-day life. Study Design: A two-phase, cross-sectional, qualitative study will be conducted through the postpositivist lens of subtle realism and informed by the principles of grounded theory methods. Study Methods: Advanced cancer patients will be recruited through the outpatient department of a tertiary cancer center. For Phase one, participants will wear an activPAL™ activity monitor and fill out a daily record sheet for seven days duration. For Phase two, the activity monitor output and daily record sheets will be used as qualitative probes for face-to-face, semistructured interviews. Concurrent coding, constant comparative analysis, and theoretical sampling will continue with the aim of achieving as close as possible to theoretical saturation. Ethics and Discussion: Ethical and scientific approval will be obtained by all local institutional review boards prior to study commencement. The findings will generate new mid-level theory about the experience of activity and quality of life in advanced cancer patients and aid in the development of a new theoretical framework for designing

  1. Phase I study of TP300 in patients with advanced solid tumors with pharmacokinetic, pharmacogenetic and pharmacodynamic analyses

    International Nuclear Information System (INIS)

    Anthoney, D Alan; Miwa, Masanori; Twelves, Christopher; Evans, TRJ; Naik, Jay; MacPherson, Iain RJ; Crawford, Donna; Hartley, John M; Hartley, Janet A; Saito, Tomohisa; Abe, Masaichi; Jones, Keith

    2012-01-01

    A Phase I dose escalation first in man study assessed maximum tolerated dose (MTD), dose-limiting toxicity (DLT) and recommended Phase II dose of TP300, a water soluble prodrug of the Topo-1 inhibitor TP3076, and active metabolite, TP3011. Eligible patients with refractory advanced solid tumors, adequate performance status, haematologic, renal, and hepatic function. TP300 was given as a 1-hour i.v. infusion 3-weekly and pharmacokinetic (PK) profiles of TP300, TP3076 and TP3011 were analysed. Polymorphisms in CYP2D6, AOX1 and UGT1A1 were studied and DNA strand-breaks measured in peripheral blood mononuclear cells (PBMCs). 32 patients received TP300 at 1, 2, 4, 6, 8, 10, 12 mg/m 2 . MTD was 10 mg/m 2 ; DLTs at 12 (2/4 patients) and 10 mg/m 2 (3/12) included thrombocytopenia and febrile neutropenia; diarrhoea was uncommon. Six patients (five had received irinotecan), had stable disease for 1.5-5 months. TP3076 showed dose proportionality in AUC and C max from 1–10 mg/m 2 . Genetic polymorphisms had no apparent influence on exposure. DNA strand-breaks were detected after TP300 infusion. TP300 had predictable hematologic toxicity, and diarrhoea was uncommon. AUC at MTD is substantially greater than for SN38. TP3076 and TP3011 are equi-potent with SN38, suggesting a PK advantage. EU-CTR2006-001345-33

  2. EMERGE: A Randomized Phase II Study of the Antibody-Drug Conjugate Glembatumumab Vedotin in Advanced Glycoprotein NMB-Expressing Breast Cancer.

    Science.gov (United States)

    Yardley, Denise A; Weaver, Robert; Melisko, Michelle E; Saleh, Mansoor N; Arena, Francis P; Forero, Andres; Cigler, Tessa; Stopeck, Alison; Citrin, Dennis; Oliff, Ira; Bechhold, Rebecca; Loutfi, Randa; Garcia, Agustin A; Cruickshank, Scott; Crowley, Elizabeth; Green, Jennifer; Hawthorne, Thomas; Yellin, Michael J; Davis, Thomas A; Vahdat, Linda T

    2015-05-10

    Glycoprotein NMB (gpNMB), a negative prognostic marker, is overexpressed in multiple tumor types. Glembatumumab vedotin is a gpNMB-specific monoclonal antibody conjugated to the potent cytotoxin monomethyl auristatin E. This phase II study investigated the activity of glembatumumab vedotin in advanced breast cancer by gpNMB expression. Patients (n = 124) with refractory breast cancer that expressed gpNMB in ≥ 5% of epithelial or stromal cells by central immunohistochemistry were stratified by gpNMB expression (tumor, low stromal intensity, high stromal intensity) and were randomly assigned 2:1 to glembatumumab vedotin (n = 83) or investigator's choice (IC) chemotherapy (n = 41). The study was powered to detect overall objective response rate (ORR) in the glembatumumab vedotin arm between 10% (null) and 22.5% (alternative hypothesis) with preplanned investigation of activity by gpNMB distribution and/or intensity (Stratum 1 to Stratum 3). Glembatumumab vedotin was well tolerated as compared with IC chemotherapy (less hematologic toxicity; more rash, pruritus, neuropathy, and alopecia). ORR was 6% (five of 83) for glembatumumab vedotin versus 7% (three of 41) for IC, without significant intertreatment differences for predefined strata. Secondary end point revealed ORR of 12% (10 of 83) versus 12% (five of 41) overall, and 30% (seven of 23) versus 9% (one of 11) for gpNMB overexpression (≥ 25% of tumor cells). Unplanned analysis showed ORR of 18% (five of 28) versus 0% (0 of 11) in patients with triple-negative breast cancer (TNBC), and 40% (four of 10) versus 0% (zero of six) in gpNMB-overexpressing TNBC. Glembatumumab vedotin is well tolerated in heavily pretreated patients with breast cancer. Although the primary end point in advanced gpNMB-expressing breast cancer was not met for all enrolled patients (median tumor gpNMB expression, 5%), activity may be enhanced in patients with gpNMB-overexpressing tumors and/or TNBC. A pivotal phase II trial (METRIC

  3. Biologic lung volume reduction in advanced upper lobe emphysema: phase 2 results.

    Science.gov (United States)

    Criner, Gerard J; Pinto-Plata, Victor; Strange, Charlie; Dransfield, Mark; Gotfried, Mark; Leeds, William; McLennan, Geoffrey; Refaely, Yael; Tewari, Sanjiv; Krasna, Mark; Celli, Bartolome

    2009-05-01

    Biologic lung volume reduction (BioLVR) is a new endobronchial treatment for advanced emphysema that reduces lung volume through tissue remodeling. Assess the safety and therapeutic dose of BioLVR hydrogel in upper lobe predominant emphysema. Open-labeled, multicenter phase 2 dose-ranging studies were performed with BioLVR hydrogel administered to eight subsegmental sites (four in each upper lobe) involving: (1) low-dose treatment (n = 28) with 10 ml per site (LD); and (2) high-dose treatment (n = 22) with 20 ml per site (HD). Safety was assessed by the incidence of serious medical complications. Efficacy was assessed by change from baseline in pulmonary function tests, dyspnea score, 6-minute walk distance, and health-related quality of life. After treatment there were no deaths and four serious treatment-related complications. A reduction in residual volume to TLC ratio at 12 weeks (primary efficacy outcome) was achieved with both LD (-6.4 +/- 9.3%; P = 0.002) and HD (-5.5 +/- 9.4%; P = 0.028) treatments. Improvements in pulmonary function in HD (6 mo: DeltaFEV(1) = +15.6%; P = 0.002; DeltaFVC = +9.1%; P = 0.034) were greater than in LD patients (6 mo: DeltaFEV(1) = +6.7%; P = 0.021; DeltaFVC = +5.1%; P = 0.139). LD- and HD-treated groups both demonstrated improved symptom scores and health-related quality of life. BioLVR improves physiology and functional outcomes up to 6 months with an acceptable safety profile in upper lobe predominant emphysema. Overall improvement was greater and responses more durable with 20 ml per site than 10 ml per site dosing. Clinical trial registered with www.clinicaltrials.gov (NCT 00435253 and NCT 00515164).

  4. Space Charge Effects and Advanced Modelling for CERN Low Energy Machines

    CERN Document Server

    AUTHOR|(CDS)2088716; Rumolo, Giovanni

    The strong space charge regime of future operation of CERN’s circular particle accelerators is investigated and mitigation strategies are developed in the framework of the present thesis. The intensity upgrade of the injector chain of Large Hadron Collider (LHC) prepares the particle accelerators to meet the requirements of the High-Luminosity LHC project. Producing the specified characteristics of the future LHC beams imperatively relies on injecting brighter bunches into the Proton Synchrotron Booster (PSB), the downstream Proton Synchrotron (PS) and eventually the Super Proton Synchrotron (SPS). The increased brightness, i.e. bunch intensity per transverse emittance, entails stronger beam self-fields which can lead to harmful interaction with betatron resonances. Possible beam emittance growth and losses as a consequence thereof threaten to degrade the beam brightness. These space charge effects are partly mitigated by the upgrade of the PSB and PS injection energies. Nevertheless, the space charge tune ...

  5. interThermalPhaseChangeFoam—A framework for two-phase flow simulations with thermally driven phase change

    Directory of Open Access Journals (Sweden)

    Mahdi Nabil

    2016-01-01

    Full Text Available The volume-of-fluid (VOF approach is a mature technique for simulating two-phase flows. However, VOF simulation of phase-change heat transfer is still in its infancy. Multiple closure formulations have been proposed in the literature, each suited to different applications. While these have enabled significant research advances, few implementations are publicly available, actively maintained, or inter-operable. Here, a VOF solver is presented (interThermalPhaseChangeFoam, which incorporates an extensible framework for phase-change heat transfer modeling, enabling simulation of diverse phenomena in a single environment. The solver employs object oriented OpenFOAM library features, including Run-Time-Type-Identification to enable rapid implementation and run-time selection of phase change and surface tension force models. The solver is packaged with multiple phase change and surface tension closure models, adapted and refined from earlier studies. This code has previously been applied to study wavy film condensation, Taylor flow evaporation, nucleate boiling, and dropwise condensation. Tutorial cases are provided for simulation of horizontal film condensation, smooth and wavy falling film condensation, nucleate boiling, and bubble condensation. Validation and grid sensitivity studies, interfacial transport models, effects of spurious currents from surface tension models, effects of artificial heat transfer due to numerical factors, and parallel scaling performance are described in detail in the Supplemental Material (see Appendix A. By incorporating the framework and demonstration cases into a single environment, users can rapidly apply the solver to study phase-change processes of interest.

  6. interThermalPhaseChangeFoam-A framework for two-phase flow simulations with thermally driven phase change

    Science.gov (United States)

    Nabil, Mahdi; Rattner, Alexander S.

    The volume-of-fluid (VOF) approach is a mature technique for simulating two-phase flows. However, VOF simulation of phase-change heat transfer is still in its infancy. Multiple closure formulations have been proposed in the literature, each suited to different applications. While these have enabled significant research advances, few implementations are publicly available, actively maintained, or inter-operable. Here, a VOF solver is presented (interThermalPhaseChangeFoam), which incorporates an extensible framework for phase-change heat transfer modeling, enabling simulation of diverse phenomena in a single environment. The solver employs object oriented OpenFOAM library features, including Run-Time-Type-Identification to enable rapid implementation and run-time selection of phase change and surface tension force models. The solver is packaged with multiple phase change and surface tension closure models, adapted and refined from earlier studies. This code has previously been applied to study wavy film condensation, Taylor flow evaporation, nucleate boiling, and dropwise condensation. Tutorial cases are provided for simulation of horizontal film condensation, smooth and wavy falling film condensation, nucleate boiling, and bubble condensation. Validation and grid sensitivity studies, interfacial transport models, effects of spurious currents from surface tension models, effects of artificial heat transfer due to numerical factors, and parallel scaling performance are described in detail in the Supplemental Material (see Appendix A). By incorporating the framework and demonstration cases into a single environment, users can rapidly apply the solver to study phase-change processes of interest.

  7. Advanced Hydrogen Turbine Development

    Energy Technology Data Exchange (ETDEWEB)

    Joesph Fadok

    2008-01-01

    advanced hydrogen turbine that meets the aggressive targets set forth for the advanced hydrogen turbine, including increased rotor inlet temperature (RIT), lower total cooling and leakage air (TCLA) flow, higher pressure ratio, and higher mass flow through the turbine compared to the baseline. Maintaining efficiency with high mass flow Syngas combustion is achieved using a large high AN2 blade 4, which has been identified as a significant advancement beyond the current state-of-the-art. Preliminary results showed feasibility of a rotor system capable of increased power output and operating conditions above the baseline. In addition, several concepts were developed for casing components to address higher operating conditions. Rare earth modified bond coat for the purpose of reducing oxidation and TBC spallation demonstrated an increase in TBC spallation life of almost 40%. The results from Phase 1 identified two TBC compositions which satisfy the thermal conductivity requirements and have demonstrated phase stability up to temperatures of 1850 C. The potential to join alloys using a bonding process has been demonstrated and initial HVOF spray deposition trials were promising. The qualitative ranking of alloys and coatings in environmental conditions was also performed using isothermal tests where significant variations in alloy degradation were observed as a function of gas composition. Initial basic system configuration schematics and working system descriptions have been produced to define key boundary data and support estimation of costs. Review of existing materials in use for hydrogen transportation show benefits or tradeoffs for materials that could be used in this type of applications. Hydrogen safety will become a larger risk than when using natural gas fuel as the work done to date in other areas has shown direct implications for this type of use. Studies were conducted which showed reduced CO{sub 2} and NOx emissions with increased plant efficiency. An approach to

  8. Patient perceptions of helpful communication in the context of advanced cancer.

    Science.gov (United States)

    Stajduhar, Kelli I; Thorne, Sally E; McGuinness, Liza; Kim-Sing, Charmaine

    2010-07-01

    Based on a secondary analysis of data from a large qualitative study on cancer care communication, we address the question: what do patients with advanced cancer identify as helpful in their communication encounters with health care providers? Communication is of critical importance to the care of patients with advanced cancer. A better understanding of what such patients identify as helpful in their communication encounters with nurses and other health care providers seems critical to creating evidence-informed recommendations for best practices. Secondary analysis of qualitative interview data. Data from 18 participants interviewed individually and 16 focus group participants, with advanced cancer in the palliative phase of care. Interpretive description methodology informed data collection and analysis. Findings suggest four key elements are critically important to consider in communications with patients in an advanced or palliative phase - respecting the importance of time, demonstrating caring, acknowledging fear and balancing hope and honesty in the provision of information. Communication is an important element in the provision of advanced cancer care. Findings emphasise the complex meanings inherent in cancer care communication and identify central themes that are fundamental to effective cancer care communication. © 2010 The Authors. Journal compilation © 2010 Blackwell Publishing Ltd.

  9. Advanced Product Water Removal and Management (APWR) Fuel Cell System, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — The proposed innovation is a passive, self-regulating, gravity-independent Advanced Product Water Removal (APWR) system for Polymer Electrolyte Membrane (PEM)...

  10. Lightweight, Efficient Power Converters for Advanced Turboelectric Aircraft Propulsion Systems, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — NASA is investigating advanced turboelectric aircraft propulsion systems that utilize superconducting motors to drive a number of distributed turbofans. In an...

  11. The role of the Istituto Superiore di Sanità as the competent authority for Phase I trials in the translation of advanced therapies

    Directory of Open Access Journals (Sweden)

    Patrizia Popoli

    2011-01-01

    Full Text Available Advanced therapy medicinal products (ATMP can offer new, effective therapeutic options for the treatment of severe illnesses, including cancer, neurodegenerative and cardiovascular diseases. Translation of advanced therapies to the clinic has been slow despite significant academic research from academia and foundations. The implementation of 2001/20 Directive in Italy established that the development of an ATMP should follow the GXP rules - good manufacturing practice (GMP for production, good laboratory practice (GLP for non clinical safety studies and good clinical practice (GCP for clinical trials. The high costs of GCP application and the needs for GMP facilities are perceived as the most important bottlenecks for the development of ATMP. Here it is pointed out that a strategic cooperation between different actors (academia, industry and experts in regulatory issues is strongly needed. In particular, it is highlighted that the Istituto Superiore di Sanità, as the competent authority for the authorization of Phase I clinical trials, has a specific responsibility in fostering the translation of safe and effective therapies for human diseases.

  12. The role of the Istituto Superiore di Sanità as the competent authority for Phase I trials in the translation of advanced therapies.

    Science.gov (United States)

    Popoli, Patrizia; Cometa, Maria Francesca; Fabi, Fulvia; Meneguz, Annarita

    2011-01-01

    Advanced therapy medicinal products (ATMP) can offer new, effective therapeutic options for the treatment of severe illnesses, including cancer, neurodegenerative and cardiovascular diseases. Translation of advanced therapies to the clinic has been slow despite significant academic research from academia and foundations. The implementation of 2001/20 Directive in Italy established that the development of an ATMP should follow the GXP rules - good manufacturing practice (GMP) for production, good laboratory practice (GLP) for non clinical safety studies and good clinical practice (GCP) for clinical trials. The high costs of GCP application and the needs for GMP facilities are perceived as the most important bottlenecks for the development of ATMP. Here it is pointed out that a strategic cooperation between different actors (academia, industry and experts in regulatory issues) is strongly needed. In particular, it is highlighted that the Istituto Superiore di Sanità, as the competent authority for the authorization of Phase I clinical trials, has a specific responsibility in fostering the translation of safe and effective therapies for human diseases.

  13. Fast digital transverse feedback system for bunch train operation in CESR

    International Nuclear Information System (INIS)

    Rogers, J.T.; Billing, M.G.; Dobbins, J.A.

    1996-01-01

    We have developed a time domain transverse feedback system with the high bandwidth needed to control transverse instabilities when the CESR e + e - collider is filled with trains of closely spaced bunches. This system is based on parallel digital processors and a stripline driver. It is capable of acting on arbitrary patterns of bunches having a minimum spacing of 14 ns. Several simplifying features have been introduced. A single shorted stripline kicker driven by one power amplifier is used to control both counter-rotating beams. The desired feedback phase is achieved by sampling the bunch position at a single location on two independently selectable beam revolutions. The system adapts to changes in the betatron tune, bunch pattern, or desired damping rate through the loading of new parameters into the digital processors via the CESR control system. The feedback system also functions as a fast gated bunch current monitor. Both vertical and horizontal loops are now used in CESR operation. The measured betatron damping rates with the transverse feedback system in operation are in agreement with the analytical prediction and a computer simulation developed in connection with this work. (author)

  14. Fast digital transverse feedback system for bunch train operation in CESR

    Energy Technology Data Exchange (ETDEWEB)

    Rogers, J T; Billing, M G; Dobbins, J A [Cornell Univ., Ithaca, NY (United States). Lab. of Nuclear Studies; and others

    1996-08-01

    We have developed a time domain transverse feedback system with the high bandwidth needed to control transverse instabilities when the CESR e{sup +}e{sup -} collider is filled with trains of closely spaced bunches. This system is based on parallel digital processors and a stripline driver. It is capable of acting on arbitrary patterns of bunches having a minimum spacing of 14 ns. Several simplifying features have been introduced. A single shorted stripline kicker driven by one power amplifier is used to control both counter-rotating beams. The desired feedback phase is achieved by sampling the bunch position at a single location on two independently selectable beam revolutions. The system adapts to changes in the betatron tune, bunch pattern, or desired damping rate through the loading of new parameters into the digital processors via the CESR control system. The feedback system also functions as a fast gated bunch current monitor. Both vertical and horizontal loops are now used in CESR operation. The measured betatron damping rates with the transverse feedback system in operation are in agreement with the analytical prediction and a computer simulation developed in connection with this work. (author)

  15. Phase Stability of a Powder Metallurgy Disk Superalloy

    Science.gov (United States)

    Gabb, Timothy P.; Gayda, John; Kantzos, P.; Telesman, Jack; Gang, Anita

    2006-01-01

    Advanced powder metallurgy superalloy disks in aerospace turbine engines now entering service can be exposed to temperatures approaching 700 C, higher than those previously encountered. They also have higher levels of refractory elements, which can increase mechanical properties at these temperatures but can also encourage phase instabilities during service. Microstructural changes including precipitation of topological close pack phase precipitation and coarsening of existing gamma' precipitates can be slow at these temperatures, yet potentially significant for anticipated disk service times exceeding 1,000 h. The ability to quantify and predict such potential phase instabilities and degradation of capabilities is needed to insure structural integrity and air worthiness of propulsion systems over the full life cycle. A prototypical advanced disk superalloy was subjected to high temperature exposures, and then evaluated. Microstructural changes and corresponding changes in mechanical properties were quantified. The results will be compared to predictions of microstructure modeling software.

  16. Electromagnetic Waves Dispersion and Interaction of an Annular Beam-Ion Channel System in Plasma Waveguide

    Directory of Open Access Journals (Sweden)

    Jixiong Xiao

    2017-01-01

    Full Text Available A linear theory for the electromagnetic properties and interactions of an annular beam-ion channel system in plasma waveguide is presented. The dispersion relations for two families of propagating modes, including the electrostatic and transverse magnetic modes, are derived. The dependencies of the dispersion behavior and interaction for different wave modes on the thickness of the annular beam and betatron oscillation frequency are studied in detail by numerical calculations. The results show that the inner and outer radii of the beam have different influences on propagation properties of the electrostatic and electromagnetic modes with different betatron oscillation parameters. In the weak ion channel situation, the two types of electrostatic waves, that is, space charge and betatron modes, have no interaction with the transverse magnetic modes. However, in the strong ion channel situation, the transverse magnetic modes will have two branches and a low frequency mode emerged as the new branch. In this case, compared with the solid beam case, the betatron modes not only can interact with the high frequency branch at small wavenumber but also can interact with the low frequency branch at large wavenumber.

  17. Safety and efficacy of first-line bevacizumab with chemotherapy in Asian patients with advanced nonsquamous NSCLC: results from the phase IV MO19390 (SAiL) study.

    Science.gov (United States)

    Tsai, Chun-Ming; Au, Joseph Siu-kie; Chang, Gee-Chen; Cheng, Ashley Chi-kin; Zhou, Caicun; Wu, Yi-long

    2011-06-01

    First-line treatment with bevacizumab combined with chemotherapy has been shown to improve outcomes in patients with advanced, nonsquamous non-small cell lung cancer (NSNSCLC) in phase III clinical trials. SAiL (MO19390), an open-label, multicenter, single-arm study, evaluated the safety and efficacy of first-line bevacizumab-based treatment in clinical practice. This report presents the results of a preplanned subanalysis of Asian patients enrolled in SAiL. Patients with untreated, locally advanced, metastatic or recurrent NSNSCLC received bevacizumab 7.5 or 15 mg/kg every 3 weeks plus chemotherapy for up to six cycles, followed by single-agent bevacizumab until disease progression. Eligibility criteria for SAiL permitted enrolment of a broad patient population. The primary end point was safety; secondary end points included time to disease progression and overall survival. The Asian intent-to-treat population comprised 314 of the 2212 patients enrolled in the SAiL trial. In the Asian subanalysis, patients received a median of nine cycles of bevacizumab, and the median follow-up was 16.4 months. The incidence of clinically significant adverse events (grade ≥3) of special interest was relatively low in this population (15.6% overall); proteinuria (7.6%), hypertension (4.8%), and bleeding (2.5%) were the most common. A total of five adverse events related to bevacizumab were reported as grade 5. Disease control rate was 94.1%, median time to disease progression was 8.3 months, and median overall survival was 18.9 months. The safety and efficacy of first-line bevacizumab-based treatment in Asian patients with advanced NSNSCLC is consistent with that demonstrated in phase III studies and in the overall SAiL population. There were no new safety signals.

  18. Advanced Air Evaporation System with Reusable Wicks for Water Recovery, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — A microgravity-compatible Advanced Air Evaporation System (AAES) is proposed for recovering nearly 100% of water from highly contaminated wastewater without concern...

  19. Advanced Product Water Removal and Management (APWR) Fuel Cell System, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — The proposed innovation is a passive, self-regulating, gravity-independent Advanced Product Water Removal and management (APWR) system for incorporation into Polymer...

  20. UTILITY ADVANCED TURBINE SYSTEMS (ATS) TECHNOLOGY READINESS TESTING PHASE 3 RESTRUCTURED (3R)

    Energy Technology Data Exchange (ETDEWEB)

    Unknown

    2000-03-17

    This scope document defines the work scope for accomplishing the design of the GE MS7001H and MS9001H (7H and 9H) combined-cycle power systems under the original ATS Phase 3 DOE Cooperative Agreement No. DE-FC21-95MC31176, and incorporates changes in scope required to convert Phase 3 to the ''restructured'' Phase 3R as defined in Amendment A012 to the Cooperative Agreement.

  1. Advanced Turbine Systems (ATS). Phase 1: System scoping and feasibility studies

    Science.gov (United States)

    White, D. J.

    1993-04-01

    As part of this involvement, Solar intends to design and commercialize a unique gas turbine system that promises high cycle efficiencies and low exhaust emissions. This engine of approximately 12-MW will be targeted for the dispersed power markets both urban and rural. Goals of 50% thermal efficiency and 8 parts-per-million by volume (ppmv) nitrogen oxide emissions were established. Reliability, availability, and maintainability (RAM) will continue to be the most important factors in the competitive marketplace. The other major goal adopted was one of reducing the cost of power produced by 10%. This reduction is based on the cost of power (COP) associated with today's engines that lie in the same horsepower range as that targeted in this study. An advanced cycle based on an approximation of the Ericsson Cycle was adopted after careful studies of a number of different cycles. This advanced intercooled, recuperated engine when fired at 2450 F will be capable of meeting the 50% efficiency goal if the cooling air requirements do not exceed 7% of the total air flow rate. This latter qualification will probably dictate the use of ceramic parts for both the nozzle guide vanes and the turbine blades. Cooling of these parts will probably be required and the 7% cooling flow allowance is thought to be adequate for such materials. Analyses of the cost of power and RAM goals show that the installed cost of this advanced engine can be approximately 50% above today's costs. This cost is based on $4.00 per million Btu fuel and a COP reduction of 10% while maintaining the same RAM as today's engines.

  2. A review of modern advances in analyses and applications of single-phase natural circulation loop in nuclear thermal hydraulics

    International Nuclear Information System (INIS)

    Basu, Dipankar N.; Bhattacharyya, Souvik; Das, P.K.

    2014-01-01

    Highlights: • Comprehensive review of state-of-the-art on single-phase natural circulation loops. • Detailed discussion on growth in solar thermal system and nuclear thermal hydraulics. • Systematic development in scaling methodologies for fabrication of test facilities. • Importance of numerical modeling schemes for stability assessment using 1-D codes. • Appraisal of current trend of research and possible future directions. - Abstract: A comprehensive review of single-phase natural circulation loop (NCL) is presented here. Relevant literature reported since the later part of 1980s has been meticulously surveyed, with occasional obligatory reference to a few pioneering studies originating prior to that period, summarizing the key observations and the present trend of research. Development in the concept of buoyancy-induced flow is discussed, with introduction to flow initiation in an NCL due to instability. Detailed discussion on modern advancement in important application areas like solar thermal systems and nuclear thermal hydraulics are presented, with separate analysis for various reactor designs working on natural circulation. Identification of scaling criteria for designing lab-scale experimental facilities has gone through a series of modification. A systematic analysis of the same is presented, considering the state-of-the-art knowledge base. Different approaches have been followed for modeling single-phase NCLs, including simplified Lorenz system mostly for toroidal loops, 1-D computational modeling for both steady-state and stability characterization and 3-D commercial system codes to have a better flow visualization. Methodical review of the relevant studies is presented following a systematic approach, to assess the gradual progression in understanding of the practical system. Brief appraisal of current research interest is reported, including the use of nanofluids for fluid property augmentation, marine reactors subjected to rolling waves

  3. A review of modern advances in analyses and applications of single-phase natural circulation loop in nuclear thermal hydraulics

    Energy Technology Data Exchange (ETDEWEB)

    Basu, Dipankar N., E-mail: dipankar.n.basu@gmail.com [Department of Mechanical Engineering, Indian Institute of Technology Guwahati, Guwahati 781039 (India); Bhattacharyya, Souvik; Das, P.K. [Department of Mechanical Engineering, Indian Institute of Technology Kharagpur, Kharagpur 721302 (India)

    2014-12-15

    Highlights: • Comprehensive review of state-of-the-art on single-phase natural circulation loops. • Detailed discussion on growth in solar thermal system and nuclear thermal hydraulics. • Systematic development in scaling methodologies for fabrication of test facilities. • Importance of numerical modeling schemes for stability assessment using 1-D codes. • Appraisal of current trend of research and possible future directions. - Abstract: A comprehensive review of single-phase natural circulation loop (NCL) is presented here. Relevant literature reported since the later part of 1980s has been meticulously surveyed, with occasional obligatory reference to a few pioneering studies originating prior to that period, summarizing the key observations and the present trend of research. Development in the concept of buoyancy-induced flow is discussed, with introduction to flow initiation in an NCL due to instability. Detailed discussion on modern advancement in important application areas like solar thermal systems and nuclear thermal hydraulics are presented, with separate analysis for various reactor designs working on natural circulation. Identification of scaling criteria for designing lab-scale experimental facilities has gone through a series of modification. A systematic analysis of the same is presented, considering the state-of-the-art knowledge base. Different approaches have been followed for modeling single-phase NCLs, including simplified Lorenz system mostly for toroidal loops, 1-D computational modeling for both steady-state and stability characterization and 3-D commercial system codes to have a better flow visualization. Methodical review of the relevant studies is presented following a systematic approach, to assess the gradual progression in understanding of the practical system. Brief appraisal of current research interest is reported, including the use of nanofluids for fluid property augmentation, marine reactors subjected to rolling waves

  4. Modeling classical and quantum radiation from laser-plasma accelerators

    Directory of Open Access Journals (Sweden)

    M. Chen

    2013-03-01

    Full Text Available The development of models and the “Virtual Detector for Synchrotron Radiation” (vdsr code that accurately describe the production of synchrotron radiation are described. These models and code are valid in the classical and linear (single-scattering quantum regimes and are capable of describing radiation produced from laser-plasma accelerators (LPAs through a variety of mechanisms including betatron radiation, undulator radiation, and Thomson/Compton scattering. Previous models of classical synchrotron radiation, such as those typically used for undulator radiation, are inadequate in describing the radiation spectra from electrons undergoing small numbers of oscillations. This is due to an improper treatment of a mathematical evaluation at the end points of an integration that leads to an unphysical plateau in the radiation spectrum at high frequencies, the magnitude of which increases as the number of oscillation periods decreases. This is important for betatron radiation from LPAs, in which the betatron strength parameter is large but the number of betatron periods is small. The code vdsr allows the radiation to be calculated in this regime by full integration over each electron trajectory, including end-point effects, and this code is used to calculate betatron radiation for cases of experimental interest. Radiation from Thomson scattering and Compton scattering is also studied with vdsr. For Thomson scattering, radiation reaction is included by using the Sokolov method for the calculation of the electron dynamics. For Compton scattering, quantum recoil effects are considered in vdsr by using Monte Carlo methods. The quantum calculation has been benchmarked with the classical calculation in a classical regime.

  5. Nucleosynthesis in advanced phases of stellar evolution: comparison between theory and observation

    International Nuclear Information System (INIS)

    Pacheco, J.A.F.

    1990-01-01

    The contamination of stellar atmospheres in advanced stages of evolution is studied, comparing observable data with theoretical expectations. The observable contaminations in some specific stars are presented. (M.C.K.)

  6. A Super Cooled, Non-toxic, Non-flammable Phase Change Material Thermal Pack for Portable Life Support Systems, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — The concept development and test of a water-based, advanced Phase Change Material (PCM) heat sink is proposed. Utilizing a novel material choice for both an...

  7. Advanced Polymeric and Organic–Inorganic Membranes for Pressure-Driven Processes

    KAUST Repository

    Le, Ngoc Lieu; Phuoc, Duong; Nunes, Suzana Pereira

    2017-01-01

    The state-of-the-art of membranes for reverse osmosis, nanofiltration, and gas separation is shortly reviewed, taking in account the most representative examples currently in application. Emphasis is also done on recent developments of advanced polymeric and organic–inorganic materials for pressure-driven processes. Many of the more recent membranes are not only polymeric but also contain an inorganic phase. Tailoring innovative materials with organic and inorganic phases coexisting in a nanoscale with multifunctionalization is an appealing approach to control at the same time diffusivity and gas solubility. Other advanced materials that are now being considered for membrane development are organic or organic–inorganic self-assemblies, metal-organic frameworks, and different forms of carbon fillers.

  8. Advanced Polymeric and Organic–Inorganic Membranes for Pressure-Driven Processes

    KAUST Repository

    Le, Ngoc Lieu

    2017-02-13

    The state-of-the-art of membranes for reverse osmosis, nanofiltration, and gas separation is shortly reviewed, taking in account the most representative examples currently in application. Emphasis is also done on recent developments of advanced polymeric and organic–inorganic materials for pressure-driven processes. Many of the more recent membranes are not only polymeric but also contain an inorganic phase. Tailoring innovative materials with organic and inorganic phases coexisting in a nanoscale with multifunctionalization is an appealing approach to control at the same time diffusivity and gas solubility. Other advanced materials that are now being considered for membrane development are organic or organic–inorganic self-assemblies, metal-organic frameworks, and different forms of carbon fillers.

  9. Measurement and correction of chromaticity in Hefei light source

    International Nuclear Information System (INIS)

    Sun Baogen; Xu Hongliang; He Duohui; Wang Junhua; Lu Ping

    2001-01-01

    The measurement and correction of chromaticity for Hefei light source is introduced. The natural chromaticity is obtained by detecting the variation of the betatron tune with the main dipole field strength. The correction chromaticity is obtained by detecting the variation of the betatron tune with the RF frequency. The theoretic analysis and formula for the two methods is given. The measurement results of chromaticity are given

  10. Programmable high power beam damper for the Tevatron

    International Nuclear Information System (INIS)

    Crisp, J.; Goodwin, R.; Gerig, R.

    1985-06-01

    A bunch-by-bunch beam damper has been developed for the Fermilab Tevatron. The system reduces betatron oscillation amplitudes and incorporates some useful machine diagnostics. The device is programmable via look-up tables so the output is an arbitrary function, on a bunch-by-bunch basis, of the beam displacement. We are presently using this feature to measure the betatron tune throughout the acceleration cycle. 4 refs

  11. Calorimetric determination of electron beam output

    Energy Technology Data Exchange (ETDEWEB)

    Novotny, J; Kovar, Z; Jandejsek, L [Ceskoslovenska Akademie Ved, Prague. Ustav Radiologicke Dozimetrie

    1979-07-01

    Two types of portable graphite calorimeter are described having modified replaceable absorbers allowing measurements of energy flux density in betatron electron beams in a range of 4 to 50 MeV. In a range of 4 to 20 MeV the total measurement error was about 1%. The results are discussed of the standardization of Siemens and Ostron medical betatrons using the said calorimeters.

  12. Some trends in the develpment of electron accelerators

    International Nuclear Information System (INIS)

    Petrov, I.I.

    1976-01-01

    Trends of further development of electron linear accelerators, betatrons and microtrons based upon the first stage of theoretic-information forecasting technique as well as upon the first stage of regressive analysis have been considered. An analysis of dynamics of scientific and technical publications and patenting dynamics has shown that electron linear accelerators are the most promising whereas further elaboration of betatrons is considered fruitless

  13. Examestane in advanced or recurrent endometrial carcinoma: a prospective phase II study by the Nordic Society of Gynecologic Oncology (NSGO)

    International Nuclear Information System (INIS)

    Lindemann, Kristina; Nordstrøm, Britta; Malander, Susanne; Christensen, Rene D; Mirza, Mansoor R; Kristensen, Gunnar B; Aavall-Lundqvist, Elisabeth; Vergote, Ignace; Rosenberg, Per; Boman, Karin

    2014-01-01

    We evaluated the efficacy and safety of the aromatase inhibitor exemestane in patients with advanced, persistent or recurrent endometrial carcinoma. We performed an open-label one-arm, two-stage, phase II study of 25 mg of oral exemestane in 51 patients with advanced (FIGO stage III-IV) or relapsed endometrioid endometrial cancer. Patients were stratified into subsets of estrogen receptor (ER) positive and ER negative patients. Recruitment to the ER negative group was stopped prematurely after 12 patients due to slow accrual. In the ER positive patients, we observed an overall response rate of 10%, and a lack of progression after 6 months in 35% of the patients. No responses were registered in the ER negative patients, and all had progressive disease within 6 months. For the total group of patients, the median progression free survival (PFS) was 3.1 months (95% CI: 2.0-4.1). In the ER positive patients the median PFS was 3.8 months (95% CI: 0.7-6.9) and in the ER negative patients it was 2.6 months (95% CI: 2.1-3-1). In the ER positive patients the median overall survival (OS) time was 13.3 months (95% CI: 7.7-18.9), in the ER negative patients the corresponding numbers were 6.1 months (95% CI: 4.1-8.2). Treatment with exemestane was well tolerated. Treatment of estrogen positive advanced or recurrent endometrial cancer with exemestane, an aromatase inhibitor, resulted in a response rate of 10% and lack of progression after 6 months in 35% of the patients. Trial identification number (Clinical Trials.gov): http://www.clinicaltrials.gov/NCT01965080. Nordic Society of Gynecological Oncology: NSGO–EC–0302. EudraCT number: 2004-001103-35

  14. The design of an automatically-tuned beamline

    International Nuclear Information System (INIS)

    Ball, M.S.; Ellison, T.J.P.; Hamilton, B.J.; Jones, W.P.

    1994-01-01

    A new 30 m beamline (BL1C) is being assembled to connect the new High Intensity Polarized Ion Source (HIPIOS) to the IUCF cyclotrons. This line is being instrumented for complete automatic optimization of all transverse and longitudinal ion optical elements by providing a unique feedback signal for each controllable device. Transversely, steerers and 4-quadrant electrostatic pickups are located approximately 90 degree apart in betatron phase advance along the beamline. Each pickup is instrumented with a single-board, 4-layer op-amp circuit (BPM system) which measures the beam intensity, horizontal (H) and vertical (V) position, and H and V 10 Hz position modulation. The transverse beam ellipse parameters are first automatically determined at the entrance to the beamline by measuring the beam size using a wire scanner as a function of the strength of a quadrupole. The computer then programs the amplitude and phase of four 10 Hz modulators which vary the current in 4 steerers to move the beam centroid around this (reduced area) ellipse in 4-dimensional phase space. The BPM system then outputs voltages proportional to the beam intensity, centroid location, and envelope. Computer algorithms will then set the steerers and quadrupoles to correct the beam position, dispersion, and envelope. Longitudinally, hardware feedback loops, with a bandwidth adjustable from 10 Hz to 30 kHz, will phase-lock the beam to the two bunching systems; another hardware system will automatically vary the buncher amplitudes to compensate for the significant and varying space charge defocusing as the beam current fluctuates. The bunchers' quiescent phases and amplitudes will be optimized using software ''synchronous detectors.''

  15. Phase II study evaluating consolidation whole abdominal intensity-modulated radiotherapy (IMRT in patients with advanced ovarian cancer stage FIGO III - The OVAR-IMRT-02 Study

    Directory of Open Access Journals (Sweden)

    Eichbaum Michael H

    2011-01-01

    Full Text Available Abstract Background The prognosis for patients with advanced FIGO stage III epithelial ovarian cancer remains poor despite the aggressive standard treatment, consisting of maximal cytoreductive surgery and platinum-based chemotherapy. The median time to recurrence is less than 2 years, with a 5-years survival rate of -20-25%. Recurrences of the disease occur mostly intraperitoneally. Ovarian cancer is a radiosensitive tumor, so that the use of whole abdominal radiotherapy (WAR as a consolidation therapy would appear to be a logical strategy. WAR used to be the standard treatment after surgery before the chemotherapy era; however, it has been almost totally excluded from the treatment of ovarian cancer during the past decade because of its high toxicity. Modern intensity-modulated radiation therapy (IMRT has the potential of sparing organs at risk like kidneys, liver, and bone marrow while still adequately covering the peritoneal cavity with a homogenous dose. Our previous phase I study showed for the first time the clinical feasibility of intensity-modulated WAR and pointed out promising results concerning treatment tolerance. The current phase-II study succeeds to the phase-I study to further evaluate the toxicity of this new treatment. Methods/design The OVAR-IMRT-02 study is a single-center one arm phase-II trial. Thirty seven patients with optimally debulked ovarian cancer stage FIGO III having a complete remission after chemotherapy will be treated with intensity-modulated WAR as a consolidation therapy. A total dose of 30 Gy in 20 fractions of 1.5 Gy will be applied to the entire peritoneal cavity including the liver surface and the pelvic and para-aortic node regions. Organ at risk are kidneys, liver (except the 1 cm-outer border, heart, vertebral bodies and pelvic bones. Primary endpoint is tolerability; secondary objectives are toxicity, quality of life, progression-free and overall survival. Discussion Intensity-modulated WAR provides

  16. Phase II study evaluating consolidation whole abdominal intensity-modulated radiotherapy (IMRT) in patients with advanced ovarian cancer stage FIGO III - The OVAR-IMRT-02 Study

    International Nuclear Information System (INIS)

    Rochet, Nathalie; Debus, Juergen; Kieser, Meinhard; Sterzing, Florian; Krause, Sonja; Lindel, Katja; Harms, Wolfgang; Eichbaum, Michael H; Schneeweiss, Andreas; Sohn, Christof

    2011-01-01

    The prognosis for patients with advanced FIGO stage III epithelial ovarian cancer remains poor despite the aggressive standard treatment, consisting of maximal cytoreductive surgery and platinum-based chemotherapy. The median time to recurrence is less than 2 years, with a 5-years survival rate of -20-25%. Recurrences of the disease occur mostly intraperitoneally. Ovarian cancer is a radiosensitive tumor, so that the use of whole abdominal radiotherapy (WAR) as a consolidation therapy would appear to be a logical strategy. WAR used to be the standard treatment after surgery before the chemotherapy era; however, it has been almost totally excluded from the treatment of ovarian cancer during the past decade because of its high toxicity. Modern intensity-modulated radiation therapy (IMRT) has the potential of sparing organs at risk like kidneys, liver, and bone marrow while still adequately covering the peritoneal cavity with a homogenous dose. Our previous phase I study showed for the first time the clinical feasibility of intensity-modulated WAR and pointed out promising results concerning treatment tolerance. The current phase-II study succeeds to the phase-I study to further evaluate the toxicity of this new treatment. The OVAR-IMRT-02 study is a single-center one arm phase-II trial. Thirty seven patients with optimally debulked ovarian cancer stage FIGO III having a complete remission after chemotherapy will be treated with intensity-modulated WAR as a consolidation therapy. A total dose of 30 Gy in 20 fractions of 1.5 Gy will be applied to the entire peritoneal cavity including the liver surface and the pelvic and para-aortic node regions. Organ at risk are kidneys, liver (except the 1 cm-outer border), heart, vertebral bodies and pelvic bones. Primary endpoint is tolerability; secondary objectives are toxicity, quality of life, progression-free and overall survival. Intensity-modulated WAR provides a new promising option in the consolidation treatment of

  17. Phase I trial of hydroxychloroquine with dose-intense temozolomide in patients with advanced solid tumors and melanoma.

    Science.gov (United States)

    Rangwala, Reshma; Leone, Robert; Chang, Yunyoung C; Fecher, Leslie A; Schuchter, Lynn M; Kramer, Amy; Tan, Kay-See; Heitjan, Daniel F; Rodgers, Glenda; Gallagher, Maryann; Piao, Shengfu; Troxel, Andrea B; Evans, Tracey L; DeMichele, Angela M; Nathanson, Katherine L; O'Dwyer, Peter J; Kaiser, Jonathon; Pontiggia, Laura; Davis, Lisa E; Amaravadi, Ravi K

    2014-08-01

    Blocking autophagy with hydroxychloroquine (HCQ) augments cell death associated with alkylating chemotherapy in preclinical models. This phase I study evaluated the maximum tolerated dose (MTD), safety, preliminary activity, pharmacokinetics, and pharmacodynamics of HCQ in combination with dose-intense temozolomide (TMZ) in patients with advanced solid malignancies. Forty patients (73% metastatic melanoma) were treated with oral HCQ 200 to 1200 mg daily with dose-intense oral TMZ 150 mg/m (2) daily for 7/14 d. This combination was well tolerated with no recurrent dose-limiting toxicities observed. An MTD was not reached for HCQ and the recommended phase II dose was HCQ 600 mg twice daily combined with dose-intense TMZ. Common toxicities included grade 2 fatigue (55%), anorexia (28%), nausea (48%), constipation (20%), and diarrhea (20%). Partial responses and stable disease were observed in 3/22 (14%) and 6/22 (27%) patients with metastatic melanoma. In the final dose cohort 2/6 patients with refractory BRAF wild-type melanoma had a near complete response, and prolonged stable disease, respectively. A significant accumulation in autophagic vacuoles (AV) in peripheral blood mononuclear cells was observed in response to combined therapy. Population pharmacokinetics (PK) modeling, individual PK simulations, and PK-pharmacodynamics (PD) analysis identified a threshold HCQ peak concentration that predicts therapy-associated AV accumulation. This study indicates that the combination of high-dose HCQ and dose-intense TMZ is safe and tolerable, and is associated with autophagy modulation in patients. Prolonged stable disease and responses suggest antitumor activity in melanoma patients, warranting further studies of this combination, or combinations of more potent autophagy inhibitors and chemotherapy in melanoma.

  18. Thermodynamics of Advanced Fuels - International Database Project

    International Nuclear Information System (INIS)

    Massara, Simone; Gueneau, Christine

    2014-01-01

    The Thermodynamics of Advanced Fuels - International Database (TAF-ID) Project was established in 2013 under the auspices of the NEA Nuclear Science Committee. The project was designed to make available a comprehensive, internationally recognised and quality-assured database of phase diagrams and thermodynamic properties of advanced nuclear fuels with a view to meeting specialised requirements for the development of advanced fuels for a future generation of nuclear reactors. Some of the specific technical objectives that this programme intends to achieve are to predict the solid, liquid and/or gas phases formed during fuel cladding chemical interactions under normal and accident conditions, to improve the control of the experimental conditions during the fabrication of fuel materials at high temperature, for example by predicting the vapour pressures of the elements (particularly of plutonium and the minor actinides) and to predict the evolution of the chemical composition of fuel under irradiation versus temperature and burn-up. This joint project, co-ordinated by the NEA, was established for an initial three-year period among nine organisations from six NEA member countries: Canada (AECL, RMCC, UOIT), France (CEA), Japan (JAEA, CRIEPI), the Netherlands (NRG), the Republic of Korea (KAERI) and the United States (US DOE). It is entirely funded by the nine signatories of the project. (authors)

  19. ADVANCED COMPUTATIONAL MODEL FOR THREE-PHASE SLURRY REACTORS

    International Nuclear Information System (INIS)

    Ahmadi, Goodarz

    2004-01-01

    In this project, an Eulerian-Lagrangian formulation for analyzing three-phase slurry flows in a bubble column was developed. The approach used an Eulerian analysis of liquid flows in the bubble column, and made use of the Lagrangian trajectory analysis for the bubbles and particle motions. The bubble-bubble and particle-particle collisions are included the model. The model predictions are compared with the experimental data and good agreement was found An experimental setup for studying two-dimensional bubble columns was developed. The multiphase flow conditions in the bubble column were measured using optical image processing and Particle Image Velocimetry techniques (PIV). A simple shear flow device for bubble motion in a constant shear flow field was also developed. The flow conditions in simple shear flow device were studied using PIV method. Concentration and velocity of particles of different sizes near a wall in a duct flow was also measured. The technique of Phase-Doppler anemometry was used in these studies. An Eulerian volume of fluid (VOF) computational model for the flow condition in the two-dimensional bubble column was also developed. The liquid and bubble motions were analyzed and the results were compared with observed flow patterns in the experimental setup. Solid-fluid mixture flows in ducts and passages at different angle of orientations were also analyzed. The model predictions were compared with the experimental data and good agreement was found. Gravity chute flows of solid-liquid mixtures were also studied. The simulation results were compared with the experimental data and discussed A thermodynamically consistent model for multiphase slurry flows with and without chemical reaction in a state of turbulent motion was developed. The balance laws were obtained and the constitutive laws established

  20. Status of NASA's Advanced Radioisotope Power Conversion Technology Research and Development

    Science.gov (United States)

    Wong, Wayne A.; Anderson, David J.; Tuttle, Karen L.; Tew, Roy C.

    2006-01-01

    NASA s Advanced Radioisotope Power Systems (RPS) development program is funding the advancement of next generation power conversion technologies that will enable future missions that have requirements that can not be met by either the ubiquitous photovoltaic systems or by current Radioisotope Power Systems (RPS). Requirements of advanced radioisotope power systems include high efficiency and high specific power (watts/kilogram) in order to meet mission requirements with less radioisotope fuel and lower mass. Other Advanced RPS development goals include long-life, reliability, and scalability so that these systems can meet requirements for a variety of future space applications including continual operation surface missions, outer-planetary missions, and solar probe. This paper provides an update on the Radioisotope Power Conversion Technology Project which awarded ten Phase I contracts for research and development of a variety of power conversion technologies consisting of Brayton, Stirling, thermoelectrics, and thermophotovoltaics. Three of the contracts continue during the current Phase II in the areas of thermoelectric and Stirling power conversion. The accomplishments to date of the contractors, project plans, and status will be summarized.