WorldWideScience

Sample records for beta imaging systems

  1. {beta} - amyloid imaging probes

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Jae Min [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    2007-04-15

    Imaging distribution of {beta} - amyloid plaques in Alzheimer's disease is very important for early and accurate diagnosis. Early trial of the {beta} -amyloid plaques includes using radiolabeled peptides which can be only applied for peripheral {beta} - amyloid plaques due to limited penetration through the blood brain barrier (BBB). Congo red or Chrysamine G derivatives were labeled with Tc-99m for imaging {beta} - amyloid plaques of Alzheimer patient's brain without success due to problem with BBB penetration. Thioflavin T derivatives gave breakthrough for {beta} - amyloid imaging in vivo, and a benzothiazole derivative [C-11]6-OH-BTA-1 brought a great success. Many other benzothiazole, benzoxazole, benzofuran, imidazopyridine, and styrylbenzene derivatives have been labeled with F-18 and I-123 to improve the imaging quality. However, [C-11]6-OH-BTA-1 still remains as the best. However, short half-life of C-11 is a limitation of wide distribution of this agent. So, it is still required to develop an Tc-99m, F-18 or I-123 labeled agent for {beta} - amyloid imaging agent.

  2. Recent technologic developments on high-resolution beta imaging systems for quantitative autoradiography and double labeling applications

    CERN Document Server

    Barthe, N; Chatti, K; Coulon, P; Maitrejean, S; 10.1016/j.nima.2004.03.014

    2004-01-01

    Two novel beta imaging systems, particularly interesting in the field of radiopharmacology and molecular biology research, were developed these last years. (1) a beta imager was derived from research conducted by Pr Charpak at CERN. This parallel plate avalanche chamber is a direct detection system of beta radioactivity, which is particularly adapted for qualitative and quantitative autoradiography. With this detector, autoradiographic techniques can be performed with emitters such as /sup 99m/Tc because this radionuclide emits many low-energy electrons and the detector has a very low sensitivity to low-range gamma -rays. Its sensitivity (smallest activity detected: 0.007 cpm/mm/sup 2/ for /sup 3/H and 0.01 for /sup 14/C), linearity (over a dynamic range of 10/sup 4/) and spatial resolution (50 mu m for /sup 3/H or /sup 99m/Tc to 150 mu m for /sup 32/P or /sup 18/F ( beta /sup +/)) gives a real interest to this system as a new imaging device. Its principle of detection is based on the analysis of light emitte...

  3. Study and design of a very high spatial resolution beta imaging system

    International Nuclear Information System (INIS)

    Donnard, J.

    2008-01-01

    The b autoradiography is a widely used technique in pharmacology or biological fields. It is able to locate in two dimensions molecules labeled with beta emitters. The development of a gaseous detector incorporating micro-mesh called PIM in the Subatech laboratory leads to the construction of a very high spatial resolution apparatus dedicated to b imaging. This device is devoted to small analysis surface of a half microscope slide in particular of 3 H or 14 C and the measured spatial resolution is 20 μm FWHM. The recent development of a new reconstruction method allows enlarging the field of investigation to high energy beta emitters such as 131 I, 18 F or 46 Sc. A new device with a large active area of 18*18 cm 2 has been built with a user friendly design. This allows to image simultaneously 10 microscope slides. Thanks to a multi-modality solution, it retains the good characteristics of spatial resolution obtained previously on a small surface. Moreover, different kinds of samples, like microscope slides or scotches can be analysed. The simulation and experimentation work achieved during this thesis led to an optimal disposition of the inner structure of the detector. These results and characterization show that the PIM structure has to be considered for a next generation of b-Imager. (author)

  4. BETAview: a digital {beta}-imaging system for dynamic studies of biological phenomena

    Energy Technology Data Exchange (ETDEWEB)

    Bertolucci, E.; Conti, M.; Mettivier, G.; Montesi, M.C. E-mail: montesi@na.infn.it; Russo, P

    2002-02-01

    We present a digital autoradiography (DAR) system, named BETAview, based on semiconductor pixel detectors and a single particle counting chip, for quantitative analysis of {beta}-emitting radioactive tracers in biological samples. The system is able to perform a real time monitoring of time-dependent biological phenomena. BETAview could be equipped either with GaAs or with Si semiconductor pixellated detectors. In this paper, we describe the results obtained with an assembly based on a Si detector, 300 {mu}m thick, segmented into 64x64 170 {mu}m size square pixels. The detector is bump-bonded to the low threshold, single particle counting chip named Medipix1, developed by a CERN-based European collaboration. The sensitive area is about 1 cm{sup 2}. Studies of background noise and detection efficiency have been performed. Moreover, time-resolved cellular uptake studies with radiolabelled molecules have been monitored. Specifically, we have followed in vivo and in real time, the [{sup 14}C]L-leucine amino acid uptake by eggs of Octopus vulgaris confirming the preliminary results of a previous paper. This opens the field of biomolecular kynetic studies with this new class of semiconductor DAR systems, whose evolution (using the Medipix2 chip, 256x256 pixels, 55 {mu}m pixel size) is soon to come.

  5. Beta attenuation transmission system (BATS)

    Energy Technology Data Exchange (ETDEWEB)

    Hagan, R.C.; Fullbright, H.J.

    1977-01-01

    The beta attenuation transmission system (BATS) is an automated radiation gauge designed for quantitative measurement of component thickness in explosive detonators. The BATS was designed and built by Group M-1, the Nondestructive Testing Group, of the Los Alamos Scientific Laboratory to measure the areal thickness, in mg/cm/sup 2/, of a cylinder of high explosive (HE) enclosed within a plastic holder. The problem is to determine the density of the HE. A /sup 90/Sr source is collimated by a 0.25 x 1.59-mm slit, and the transmitted beta-particle flux is detected by a plastic scintillator, coupled to a photomultiplier tube. The detonator is transported through the radiation beam by a leadscrew, ballnut, stepping-motor combination. Continuous analog position data are available, derived from the output from a linear-actuated potentiometer attached to the scanner. A linear electrometer amplifies the detected signal, which is then integrated for a preselected time, to obtain the desired statistical accuracy. A microprocessor (..mu..P) is used to control the scanner position and to make the data readings at the assigned positions. The data are stored, and, at the completion of the scan, are processed into the desired format. The final answer is displayed to the operator or output to a peripheral device for permanent record. The characteristics of the radiation source, the collimator, the signal detection and conditioning, and the final results are described in detail. The scanner and the microprocessor control system are briefly outlined.

  6. Beta attenuation transmission system (BATS)

    International Nuclear Information System (INIS)

    Hagan, R.C.; Fullbright, H.J.

    1977-01-01

    The beta attenuation transmission system (BATS) is an automated radiation gauge designed for quantitative measurement of component thickness in explosive detonators. The BATS was designed and built by Group M-1, the Nondestructive Testing Group, of the Los Alamos Scientific Laboratory to measure the areal thickness, in mg/cm 2 , of a cylinder of high explosive (HE) enclosed within a plastic holder. The problem is to determine the density of the HE. A 90 Sr source is collimated by a 0.25 x 1.59-mm slit, and the transmitted beta-particle flux is detected by a plastic scintillator, coupled to a photomultiplier tube. The detonator is transported through the radiation beam by a leadscrew, ballnut, stepping-motor combination. Continuous analog position data are available, derived from the output from a linear-actuated potentiometer attached to the scanner. A linear electrometer amplifies the detected signal, which is then integrated for a preselected time, to obtain the desired statistical accuracy. A microprocessor (μP) is used to control the scanner position and to make the data readings at the assigned positions. The data are stored, and, at the completion of the scan, are processed into the desired format. The final answer is displayed to the operator or output to a peripheral device for permanent record. The characteristics of the radiation source, the collimator, the signal detection and conditioning, and the final results are described in detail. The scanner and the microprocessor control system are briefly outlined

  7. Development of Simultaneous Beta-and-Coincidence-Gamma Imager for Plant Imaging Research

    Energy Technology Data Exchange (ETDEWEB)

    Tai, Yuan-Chuan [Washington Univ., St. Louis, MO (United States). School of Medicine

    2016-09-30

    The goal of this project is to develop a novel imaging system that can simultaneously acquire beta and coincidence gamma images of positron sources in thin objects such as leaves of plants. This hybrid imager can be used to measure carbon assimilation in plants quantitatively and in real-time after C-11 labeled carbon-dioxide is administered. A better understanding of carbon assimilation, particularly under the increasingly elevated atmospheric CO2 level, is extremely critical for plant scientists who study food crop and biofuel production. Phase 1 of this project is focused on the technology development with 3 specific aims: (1) develop a hybrid detector that can detect beta and gamma rays simultaneously; (2) develop an imaging system that can differentiate these two types of radiation and acquire beta and coincidence gamma images in real-time; (3) develop techniques to quantify radiotracer distribution using beta and gamma images. Phase 2 of this project is to apply technologies developed in phase 1 to study plants using positron-emitting radionuclide such as 11C to study carbon assimilation in biofuel plants.

  8. Progress in molecular nuclear medicine imaging of pancreatic beta cells

    International Nuclear Information System (INIS)

    Wu Haifei; Yin Hongyan; Liu Shuai; Zhang Yifan

    2010-01-01

    Diabetes mellitus is a common and frequently occurring disease which seriously threaten the health of human beings. Type 1 and type 2 diabetes respectively results from being destroyed and insufficient beta-cell mass. The associated symptoms appear until 50%-60% decrease of beta-cell mass. Because pancreas is deeply located in the body, with few beta-cell mass, the current methods of clinical diagnosis are invasive and late. So diagnosis of metabolism disease of beta-cell early non-invasively becomes more and more popular, imaging diagnosis of diabetes mellitus becomes the focus of researches, but how to estimate the mass of beta-cell still an important subject in imaging technology. (authors)

  9. A hand-held beta imaging probe for FDG.

    Science.gov (United States)

    Singh, Bipin; Stack, Brendan C; Thacker, Samta; Gaysinskiy, Valeriy; Bartel, Twyla; Lowe, Val; Cool, Steven; Entine, Gerald; Nagarkar, Vivek

    2013-04-01

    Advances in radiopharmaceuticals and clinical understanding have escalated the use of intraoperative gamma probes in surgery. However, most probes on the market are non-imaging gamma probes that suffer from the lack of ancillary information of the surveyed tissue area. We have developed a novel, hand-held digital Imaging Beta Probe™ (IBP™) to be used in surgery in conjunction with beta-emitting radiopharmaceuticals such as (18)FDG, (131)I and (32)P for real-time imaging of a surveyed area with higher spatial resolution and sensitivity and greater convenience than existing instruments. We describe the design and validation of a hand-held beta probe intended to be used as a visual mapping device to locate and confirm excision of (18)FDG-avid primary tumors and metastases in an animal model. We have demonstrated a device which can generate beta images from (18)FDG avid lesions in an animal model. It is feasible to image beta irradiation in animal models of cancer given (18)FDG. This technology may be applied to clinical mapping of tumors and/or their metastases in the operating room. Visual image depiction of malignancy may aid the surgeon in localization and excision of lesions of interest.

  10. Efficiency enhancements for MCP-based beta autoradiography imaging

    CERN Document Server

    Lees, J E

    2002-01-01

    We describe three approaches to increase the beta detection efficiency of microchannel plate detectors for biological beta autoradiography:(a)reversing the microchannel plate (MCP) bias polarity, changing the conventional high negative voltage on the input MCP to a grounded input, (b) a reduction in MCP pore size from 12.5 to 6 mu m, (c) using a CsI coating as an efficient secondary electron emitter. We also present our first measurements of double-tracer ( sup 3 H and sup 1 sup 4 C) imaging using pulse height analysis to distinguish between isotopes.

  11. Imaging system

    International Nuclear Information System (INIS)

    Froggatt, R.J.

    1981-01-01

    The invention provides a two dimensional imaging system in which a pattern of radiation falling on the system is detected to give electrical signals for each of a plurality of strips across the pattern. The detection is repeated for different orientations of the strips and the whole processed by compensated back projection. For a shadow x-ray system a plurality of strip x-ray detectors are rotated on a turntable. For lower frequencies the pattern may be rotated with a Dove prism and the strips condensed to suit smaller detectors with a cylindrical lens. (author)

  12. Imaging system

    International Nuclear Information System (INIS)

    Rushbrooke, J.G.; Ansorge, R.E.

    1987-01-01

    A moving object such as a container on a conveyor belt is imaged by an optical system onto a charge coupled device array in which the lines of the array are arranged perpendicular to the direction of motion of the object. The speed of movement of the object is sensed to generate electrical signals which are processed to provide shift signals enabling the shifting of data row to row in the array in synchronism with the movement of the container. The electrical charge associated with a given point on the array is transferred from one line to the other until it appears at the last line of the array, from which it is read out in known manner in conjunction with all other electrical charges associated with the row of charge coupled devices in the last line of the array. Due to the integrating effect achieved, the aperture of the imaging system can be much smaller than otherwise would be required, and/or the level of light illumination can be reduced. The imaging system can be applied to X-ray inspection devices, aerial surveillance or scanning of moving documents in copying processes. (author)

  13. The imaging pin detector - a simple and effective new imaging device for soft x-rays and soft beta emissions

    International Nuclear Information System (INIS)

    Bateman, J.E.

    1984-01-01

    The development of a new bidimensional imaging detector system for soft X and beta radiations is reported. Based on the detection of the differential induction signals on pickup electrodes placed around a point anode in a gas avalanche detector, the system described has achieved a spatial resolution of better than 1mm fwhm over a field of 30mm diameter while preserving excellent pulse height resolution. The present device offers considerable potential as a cheap and robust imaging system for applications in X-ray diffraction and autoradiography. (author)

  14. Preliminary Results of Nuclear Fluorescence Imaging of Alpha and Beta Emitting Sources

    International Nuclear Information System (INIS)

    Feener, Jessica S.; Charlton, William S.

    2013-06-01

    The preliminary results from a series of nuclear fluorescence imaging experiments using a variety of radioactive sources and shielding are given. These experiments were done as part of a proof of concept to determine if nuclear fluorescence imaging could be used as a safeguards measurements tool or for nuclear warhead verification for nuclear arms control treaties such as the New Strategic Arms Reduction Treaty and the Fissile Material Cut-Off Treaty. An off-the-shelf Princeton Instruments charged coupled device camera system was used to image the emission of fluorescence photons from the de-excitation of nitrogen molecules in air that have been excited by ionizing radiation. The fluorescence emissions are primarily in the near ultraviolet range; between the wavelengths of 300 and 400 nm. Fluorescent imaging techniques are currently being investigated in a number of applications. A French research team has successfully demonstrated this concept for remote imaging of alpha contamination. It has also been shown that the phenomenon can be seen through translucent materials and that alpha radiation can be seen in the presence of large gamma backgrounds. Additionally, fluorescence telescopes and satellites utilize the de-excitation of nitrogen molecules to observe cosmic ray showers in the atmosphere. In cosmic ray shower detection, electrons are the main contributor to the excitation of the of nitrogen molecules in air. The experiments presented in this paper were designed to determine if the imaging system could observe beta emitting sources, differentiate between beta emitters and alpha emitting materials such as uranium oxide and uranium metal, and to further investigate the phenomenon through translucent and non-translucent materials. The initial results show that differentiation can be made between beta and alpha emitting sources and that the device can observe the phenomenon through very thin non-transparent material. Additionally, information is given on the

  15. Nicotinic {alpha}4{beta}2 receptor imaging agents

    Energy Technology Data Exchange (ETDEWEB)

    Pichika, Rama [Brain Imaging Center, Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697-3960 (United States); Easwaramoorthy, Balasubramaniam [Brain Imaging Center, Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697-3960 (United States); Collins, Daphne [Brain Imaging Center, Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697-3960 (United States); Christian, Bradley T. [Department of Nuclear Medicine, Kettering Medical Center, Dayton, OH 45429 (United States); Shi, Bingzhi [Department of Nuclear Medicine, Kettering Medical Center, Dayton, OH 45429 (United States); Narayanan, Tanjore K. [Department of Nuclear Medicine, Kettering Medical Center, Dayton, OH 45429 (United States); Potkin, Steven G. [Brain Imaging Center, Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697-3960 (United States); Mukherjee, Jogeshwar [Brain Imaging Center, Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697-3960 (United States)]. E-mail: j.mukherjee@uci.edu

    2006-04-15

    The {alpha}4{beta}2 nicotinic acetylcholine receptor (nAChR) has been implicated in various neurodegenerative diseases. Optimal positron emission tomography (PET) imaging agents are therefore highly desired for this receptor. We report here the development and initial evaluation of 2-fluoro-3-[2-((S)-3-pyrrolinyl)methoxy]pyridine (nifene). In vitro binding affinity of nifene in rat brain homogenate using {sup 3}H-cytisine exhibited a K {sub i}=0.50 nM for the {alpha}4{beta}2 sites. The radiosynthesis of 2-{sup 18}F-fluoro-3-[2-((S)-3-pyrrolinyl)methoxy]pyridine ({sup 18}F-nifene) was accomplished in 2.5 h with an overall radiochemical yield of 40-50%, decay corrected. The specific activity was estimated to be approx. 37-185 GBq/{mu}mol. In vitro autoradiography in rat brain slices indicated selective binding of {sup 18}F-nifene to anteroventral thalamic (AVT) nucleus, thalamus, subiculum, striata, cortex and other regions consistent with {alpha}4{beta}2 receptor distribution. Rat cerebellum showed some binding, whereas regions in the hippocampus had the lowest binding. The highest ratio of >13 between AVT and cerebellum was measured for {sup 18}F-nifene in rat brain slices. The specific binding was reduced (>95%) by 300 {mu}M nicotine in these brain regions. Positron emission tomography imaging study of {sup 18}F-nifene (130 MBq) in anesthetized rhesus monkey was carried out using an ECAT EXACT HR+ scanner. PET study showed selective maximal uptake in the regions of the anterior medial thalamus, ventro-lateral thalamus, lateral geniculate, cingulate gyrus, temporal cortex including the subiculum. The cerebellum in the monkeys showed lower binding than the other regions. Thalamus-to-cerebellum ratio peaked at 30-35 min postinjection to a value of 2.2 and subsequently reduced. The faster binding profile of {sup 18}F-nifene indicates promise as a PET imaging agent and thus needs further evaluation.

  16. Imaging manifestations of acquired elastopathy resembling pseudoxanthoma elasticum in patients with beta thalassaemia major and sickle cell disease

    International Nuclear Information System (INIS)

    Narayana, Harish; Cheng, Ken; Lau, Ken; Harish, Radhika; Bowden, Donald K.

    2016-01-01

    Development of an acquired systemic elastopathy resembling pseudoxanthoma elasticum in patients with chronic haemoglobinopathies such as beta thalassaemia major and sickle cell disease is well documented. There is paucity of any comprehensive literature on the radiological manifestations of this entity. This pictorial review aims to describe and illustrate the multi system and multi modality imaging findings of this condition.

  17. Medical Imaging System

    Science.gov (United States)

    1991-01-01

    The MD Image System, a true-color image processing system that serves as a diagnostic aid and tool for storage and distribution of images, was developed by Medical Image Management Systems, Huntsville, AL, as a "spinoff from a spinoff." The original spinoff, Geostar 8800, developed by Crystal Image Technologies, Huntsville, incorporates advanced UNIX versions of ELAS (developed by NASA's Earth Resources Laboratory for analysis of Landsat images) for general purpose image processing. The MD Image System is an application of this technology to a medical system that aids in the diagnosis of cancer, and can accept, store and analyze images from other sources such as Magnetic Resonance Imaging.

  18. The Fermilab Collider D/Phi/ low BETA system

    Energy Technology Data Exchange (ETDEWEB)

    McInturff, A.D.; Carson, J.; Collins, T.; Koepke, K.; Malamud, E.; Mantsch, P.; Niemann, R.; Riddiford, A.

    1988-06-01

    A new low BETA system has been designed to serve the detector facility under construction at the D/Phi/ location of the Fermilab Superconducting Collider. The low BETA system consists of 18 special cold iron quadrupoles powered as 11 independent circuits that can adjust the BETA value at the intersection point down to 25 cm. Low beta is achieved with a set of 1.4 T/cm, two shell, high current quadrupoles. Smaller 0.7 T/cm, single shell trim quadrupoles are used to match the low beta insertion to the rest of the accelerator lattice. Gaps have been left in the lattice for electrostatic separators to separate the proton and antiproton beams everywhere except at the desired collision points. 6 refs., 6 figs., 3 tabs.

  19. Design study for a two-color beta measurement system

    Science.gov (United States)

    1982-01-01

    Design analysis of the beam splitter combined two color beta system is presented. Conventional and dichroic beam splitters are discussed. Design analysis of the beta system employing two beams with focusing at separate points is presented. Alterations and basic parameters of the two beam system are discussed. Alterations in the focus of the initial laser and the returning beams are also discussed. Heterodyne efficiencies for the on axis and off axis reflected radiation are included.

  20. Histologic examination of the rat central nervous system after intrathecal administration of human beta-endorphin

    DEFF Research Database (Denmark)

    Hée, P.; Klinken, Leif; Ballegaard, Martin

    1992-01-01

    Neuropathology, analgesics - intrathecal, central nervous system, histology, human beta-endorphin, toxicity......Neuropathology, analgesics - intrathecal, central nervous system, histology, human beta-endorphin, toxicity...

  1. Image processing of integrated video image obtained with a charged-particle imaging video monitor system

    International Nuclear Information System (INIS)

    Iida, Takao; Nakajima, Takehiro

    1988-01-01

    A new type of charged-particle imaging video monitor system was constructed for video imaging of the distributions of alpha-emitting and low-energy beta-emitting nuclides. The system can display not only the scintillation image due to radiation on the video monitor but also the integrated video image becoming gradually clearer on another video monitor. The distortion of the image is about 5% and the spatial resolution is about 2 line pairs (lp)mm -1 . The integrated image is transferred to a personal computer and image processing is performed qualitatively and quantitatively. (author)

  2. Functional imaging of interleukin 1 beta expression in inflammatory process using bioluminescence imaging in transgenic mice

    Directory of Open Access Journals (Sweden)

    Liu Zhihui

    2008-08-01

    Full Text Available Abstract Background Interleukin 1 beta (IL-1β plays an important role in a number of chronic and acute inflammatory diseases. To understand the role of IL-1β in disease processes and develop an in vivo screening system for anti-inflammatory drugs, a transgenic mouse line was generated which incorporated the transgene firefly luciferase gene driven by a 4.5-kb fragment of the human IL-1β gene promoter. Luciferase gene expression was monitored in live mice under anesthesia using bioluminescence imaging in a number of inflammatory disease models. Results In a LPS-induced sepsis model, dramatic increase in luciferase activity was observed in the mice. This transgene induction was time dependent and correlated with an increase of endogenous IL-1β mRNA and pro-IL-1β protein levels in the mice. In a zymosan-induced arthritis model and an oxazolone-induced skin hypersensitivity reaction model, luciferase expression was locally induced in the zymosan injected knee joint and in the ear with oxazolone application, respectively. Dexamethasone suppressed the expression of luciferase gene both in the acute sepsis model and in the acute arthritis model. Conclusion Our data suggest that the transgenic mice model could be used to study transcriptional regulation of the IL-1β gene expression in the inflammatory process and evaluation the effect of anti-inflammatory drug in vivo.

  3. Imaging the Beta-cell mass: why and how

    DEFF Research Database (Denmark)

    Saudek, Frantisek; Brogren, Carl-Henrik; Manohar, Srirang

    2008-01-01

    is called dihydrotetrabenazine (DTBZ), antibodies to zinc transporter (ZnT-8) and the monoclonal antibody IC2. While DTBZ and antibodies to ZnT-8 showed binding activities to more than beta-cells, the anti-IC2 monoclonal antibody showed binding properties exclusively to insulin-producing beta...

  4. Medical imaging systems

    Science.gov (United States)

    Frangioni, John V

    2013-06-25

    A medical imaging system provides simultaneous rendering of visible light and diagnostic or functional images. The system may be portable, and may include adapters for connecting various light sources and cameras in open surgical environments or laparascopic or endoscopic environments. A user interface provides control over the functionality of the integrated imaging system. In one embodiment, the system provides a tool for surgical pathology.

  5. What are the potential benefits of clinical beta-cell imaging in diabetes mellitus?

    Science.gov (United States)

    Göke, Burkhard

    2010-05-01

    Previously, studies of the endocrine pancreatic beta-cell were mainly performed ex vivo by morphological means. This data supported the analysis of pathophysiological changes in the pancreatic islet during insults such as diabetes mellitus. Metabolic testing of the pancreatic islet by assaying hormone parameters such als plasma insulin or C-peptide combined with more or less sophisticated calculations allowed conclusions about states of insulin resistance or secretory failure. It also allowed certain correlations of endocrine function with beta-cell mass. Today, with firmer pathophysiological concepts about beta-cell failure, modern protocols of islet transplantation, and drugs on the market coming with promises of preservation or even expansion of beta-cell mass in diabetes mellitus it has become very attractive to search for tools measuring beta-cell mass, if possible even repeatingly in the same organism in vivo. From a clinical point of view, the potential of pancreatic beta-cell mass imaging technologies is looked upon with high expectations. Methodologically, the decisive question is whether it is likely that future beta-cell imaging will provide significant advantages over the metabolic methods already in hand. With new in vivo tools, studies of beta-cell mass and function may offer even new approaches stratifying patients to anti-diabetic therapies.

  6. Cerenkov radiation imaging as a method for quantitative measurements of beta particles in a microfluidic chip

    International Nuclear Information System (INIS)

    Cho, Jennifer S; Taschereau, Richard; Olma, Sebastian; Liu Kan; Chen Yichun; Shen, Clifton K-F; Van Dam, R Michael; Chatziioannou, Arion F

    2009-01-01

    It has been observed that microfluidic chips used for synthesizing 18 F-labeled compounds demonstrate visible light emission without nearby scintillators or fluorescent materials. The origin of the light was investigated and found to be consistent with the emission characteristics from Cerenkov radiation. Since 18 F decays through the emission of high-energy positrons, the energy threshold for beta particles, i.e. electrons or positrons, to generate Cerenkov radiation was calculated for water and polydimethylsiloxane (PDMS), the most commonly used polymer-based material for microfluidic chips. Beta particles emitted from 18 F have a continuous energy spectrum, with a maximum energy that exceeds this energy threshold for both water and PDMS. In addition, the spectral characteristics of the emitted light from 18 F in distilled water were also measured, yielding a broad distribution from 300 nm to 700 nm, with higher intensity at shorter wavelengths. A photograph of the 18 F solution showed a bluish-white light emitted from the solution, further suggesting Cerenkov radiation. In this study, the feasibility of using this Cerenkov light emission as a method for quantitative measurements of the radioactivity within the microfluidic chip in situ was evaluated. A detector previously developed for imaging microfluidic platforms was used. The detector consisted of a charge-coupled device (CCD) optically coupled to a lens. The system spatial resolution, minimum detectable activity and dynamic range were evaluated. In addition, the calibration of a Cerenkov signal versus activity concentration in the microfluidic chip was determined. This novel method of Cerenkov radiation measurements will provide researchers with a simple yet robust quantitative imaging tool for microfluidic applications utilizing beta particles.

  7. Iodine-123 labelled N-(2-fluoroethyl)-2{beta}-carbomethoxy-3{beta}-(4-iodophenyl)nortropane for dopamine transporter imaging in the living human brain

    Energy Technology Data Exchange (ETDEWEB)

    Kuikka, J.T. [Dept. of Clinical Physiology, Kuopio Univ. Hospital (Finland); AAkerman, K. [Dept. of Clinical Physiology, Kuopio Univ. Hospital (Finland); Bergstroem, K.A. [Dept. of Clinical Physiology, Kuopio Univ. Hospital (Finland); Karhu, J. [Dept. of Clinical Neurophysiology, Kuopio Univ. Hospital (Finland); Hiltunen, J. [MAP Medical Technologies Oy, Tikkakoski (Finland); Haukka, J. [MAP Medical Technologies Oy, Tikkakoski (Finland); Heikkinen, J. [Dept. of Clinical Physiology, Kuopio Univ. Hospital (Finland); Tiihonen, J. [Dept. of Forensic Psychiatry, Niuvanniemi Hospital, Kuopio (Finland); Wang, S. [Research Biochemical International (RBI), Natick, MA (United States); Neumeyer, J.L. [Research Biochemical International (RBI), Natick, MA (United States)

    1995-07-01

    Here we report a pilot comparison of [{sup 123}I]{beta}-CIT and [{sup 123}I]{beta}-CIT-FP with a new tropane derivative, [{sup 123}I]N-(2-fluoroethyl)-2{beta}-carbomethoxy-3{beta}-(4-iodophenyl)nortropane ([{sup 123}I]{beta}-CIT-FE), using SPET imaging in four healthy male subjects. Peak uptake of [{sup 123}I]{beta}-CIT-FE into the basal ganglia occurred very rapidly (0.5 h after injection of tracer), after which the striatal washout obeyed a bi-exponential form. The specific DAT binding of [{sup 123}I]{beta}-CIT-FE into the basal ganglia was somewhat less (0.785{+-}0.117) than that of [{sup 123}I]{beta}-CIT (0.922{+-}0.004) or [{sup 123}I]{beta}-CIT-FP (0.813{+-}0.047). All these tracers have excellent imaging quality in healthy control subjects. However, the relatively fast washout of [{sup 123}I]{beta}-CIT-FE and low temporal resolution of older SPET cameras may limit the use of this tracer to the measurement of the DAT density. (orig./UG)

  8. Data Acquisition System On Beta Installation

    International Nuclear Information System (INIS)

    Abtokhi, Ahmad; Nurhanan; Sudarno; Sumarno, Edy

    2000-01-01

    Data acquisition system is needed on every installation. This is important used to monitoring and processing data to get information desired. This system applied to β installation which is facility to carry out experiments on accident condition like as reflooding phenomena in test section. The 16 exp.th channel data acquisition system is drived by ADC 0804 and programme application DELPHI

  9. Y-formalism and curved {beta}-{gamma} systems

    Energy Technology Data Exchange (ETDEWEB)

    Grassi, Pietro Antonio [DISTA, Universita del Piemonte Orientale, via Bellini 25/g, 15100 Alessandria (Italy); INFN - Sezione di Torino (Italy)], E-mail: antonio.pietro.grassi@cern.ch; Oda, Ichiro [Department of Physics, Faculty of Science, University of the Ryukyus, Nishihara, Okinawa 903-0213 (Japan); Tonin, Mario [Dipartimento di Fisica, Universita degli Studi di Padova, INFN, Sezionedi Padova, Via F. Marzolo 8, 35131 Padova (Italy)

    2009-01-01

    We adopt the Y-formalism to study {beta}-{gamma} systems on hypersurfaces. We compute the operator product expansions of gauge-invariant currents and we discuss some applications of the Y-formalism to model on Calabi-Yau spaces.

  10. Imaging of alpha(v)beta(3) expression by a bifunctional chimeric RGD peptide not cross-reacting with alpha(v)beta(5).

    Science.gov (United States)

    Zannetti, Antonella; Del Vecchio, Silvana; Iommelli, Francesca; Del Gatto, Annarita; De Luca, Stefania; Zaccaro, Laura; Papaccioli, Angela; Sommella, Jvana; Panico, Mariarosaria; Speranza, Antonio; Grieco, Paolo; Novellino, Ettore; Saviano, Michele; Pedone, Carlo; Salvatore, Marco

    2009-08-15

    To test whether a novel bifunctional chimeric peptide comprising a cyclic Arg-Gly-Asp pentapeptide covalently bound to an echistatin domain can discriminate alpha(v)beta(3) from alpha(v)beta(5) integrin, thus allowing the in vivo selective visualization of alpha(v)beta(3) expression by single-photon and positron emission tomography (PET) imaging. The chimeric peptide was preliminarily tested for inhibition of alpha(v)beta(3)-dependent cell adhesion and competition of 125I-echistatin binding to membrane of stably transfected K562 cells expressing alpha(v)beta(3) (Kalpha(v)beta(3)) or alpha(v)beta(5) (Kalpha(v)beta(5)) integrin. The chimeric peptide was then conjugated with diethylenetriaminepentaacetic acid and labeled with 111In for single-photon imaging, whereas a one-step procedure was used for labeling the full-length peptide and a truncated derivative, lacking the last five C-terminal amino acids, with 18F for PET imaging. Nude mice bearing tumors from Kalpha(v)beta(3), Kalpha(v)beta(5), U87MG human glioblastoma, and A431 human epidermoid cells were subjected to single-photon and PET imaging. Adhesion and competitive binding assays showed that the novel chimeric peptide selectively binds to alpha(v)beta(3) integrin and does not cross-react with alpha(v)beta(5). In agreement with in vitro findings, single-photon and PET imaging studies showed that the radiolabeled chimeric peptide selectively localizes in tumor xenografts expressing alphavbeta3 and fails to accumulate in those expressing alpha(v)beta(5) integrin. When 18F-labeled truncated derivative was used for PET imaging, alphavbeta3- and alpha(v)beta(5)-expressing tumors were visualized, indicating that the five C-terminal amino acids are required to differentially bind the two integrins. Our findings indicate that the novel chimeric Arg-Gly-Asp peptide, having no cross-reaction with alphavbeta5 integrin, allows highly selective alphavbeta3 expression imaging and monitoring.

  11. A novel computer-assisted image analysis of [{sup 123}I]{beta}-CIT SPECT images improves the diagnostic accuracy of parkinsonian disorders

    Energy Technology Data Exchange (ETDEWEB)

    Goebel, Georg [Innsbruck Medical University, Department of Medical Statistics, Informatics and Health Economics, Innsbruck (Austria); Seppi, Klaus; Wenning, Gregor K.; Poewe, Werner; Scherfler, Christoph [Innsbruck Medical University, Department of Neurology, Innsbruck (Austria); Donnemiller, Eveline; Warwitz, Boris; Virgolini, Irene [Innsbruck Medical University, Department of Nuclear Medicine, Innsbruck (Austria)

    2011-04-15

    The purpose of this study was to develop an observer-independent algorithm for the correct classification of dopamine transporter SPECT images as Parkinson's disease (PD), multiple system atrophy parkinson variant (MSA-P), progressive supranuclear palsy (PSP) or normal. A total of 60 subjects with clinically probable PD (n = 15), MSA-P (n = 15) and PSP (n = 15), and 15 age-matched healthy volunteers, were studied with the dopamine transporter ligand [{sup 123}I]{beta}-CIT. Parametric images of the specific-to-nondisplaceable equilibrium partition coefficient (BP{sub ND}) were generated. Following a voxel-wise ANOVA, cut-off values were calculated from the voxel values of the resulting six post-hoc t-test maps. The percentages of the volume of an individual BP{sub ND} image remaining below and above the cut-off values were determined. The higher percentage of image volume from all six cut-off matrices was used to classify an individual's image. For validation, the algorithm was compared to a conventional region of interest analysis. The predictive diagnostic accuracy of the algorithm in the correct assignment of a [{sup 123}I]{beta}-CIT SPECT image was 83.3% and increased to 93.3% on merging the MSA-P and PSP groups. In contrast the multinomial logistic regression of mean region of interest values of the caudate, putamen and midbrain revealed a diagnostic accuracy of 71.7%. In contrast to a rater-driven approach, this novel method was superior in classifying [{sup 123}I]{beta}-CIT-SPECT images as one of four diagnostic entities. In combination with the investigator-driven visual assessment of SPECT images, this clinical decision support tool would help to improve the diagnostic yield of [{sup 123}I]{beta}-CIT SPECT in patients presenting with parkinsonism at their initial visit. (orig.)

  12. Synthesis, radiolabeling and baboon SPECT imaging of 2{beta}-carbomethoxy-3{beta}-(3'-[{sup 123}I]iodophenyl)tropane ([{sup 123}I]YP256) as a serotonin transporter radiotracer

    Energy Technology Data Exchange (ETDEWEB)

    Bois, Frederic; Baldwin, Ronald M.; Amici, Louis; Al-Tikriti, Mohammed S. [Yale University, School of Medicine, VA Connecticut HCS (116A2), West Haven, CT 06516 (United States); Kula, Nora; Baldessarini, Ross [Department of Psychiatry and Neuroscience Program, Harvard Medical School, Mailman Research Center McLean Division of Massachusetts General Hospital, Belmont, MA 02478 (United States); Innis, Robert B.; Staley, Julie K. [Yale University, School of Medicine, VA Connecticut HCS (116A2), West Haven, CT 06516 (United States); Tamagnan, Gilles D. [Yale University, School of Medicine, VA Connecticut HCS (116A2), West Haven, CT 06516 (United States); Institute for Neurodegenerative Disorders, New Haven, CT 06510 (United States)], E-mail: gtamagnan@indd.org

    2008-01-15

    To develop a potential SPECT probe to evaluate the integrity of the serotoninergic system (5-HTT) whose dysfunction is linked to several disease conditions such as Parkinson's disease, Alzheimer's disease and depression, we report the synthesis, radiolabeling and in vivo baboon imaging of 2{beta}-carbomethoxy-3{beta}-(3'-[{sup 123}I]iodophenyl) tropane (YP256, ). The radiolabeling was performed by iododestannylation using sodium [{sup 123}I]iodide and peracetic acid. Although the ligand displayed high selectivity for 5-HTT over dopamine transporter in vitro, SPECT imaging in baboons did not reveal selective 5-HTT accumulation in brain in vivo.

  13. Multipurpose Hyperspectral Imaging System

    Science.gov (United States)

    Mao, Chengye; Smith, David; Lanoue, Mark A.; Poole, Gavin H.; Heitschmidt, Jerry; Martinez, Luis; Windham, William A.; Lawrence, Kurt C.; Park, Bosoon

    2005-01-01

    A hyperspectral imaging system of high spectral and spatial resolution that incorporates several innovative features has been developed to incorporate a focal plane scanner (U.S. Patent 6,166,373). This feature enables the system to be used for both airborne/spaceborne and laboratory hyperspectral imaging with or without relative movement of the imaging system, and it can be used to scan a target of any size as long as the target can be imaged at the focal plane; for example, automated inspection of food items and identification of single-celled organisms. The spectral resolution of this system is greater than that of prior terrestrial multispectral imaging systems. Moreover, unlike prior high-spectral resolution airborne and spaceborne hyperspectral imaging systems, this system does not rely on relative movement of the target and the imaging system to sweep an imaging line across a scene. This compact system (see figure) consists of a front objective mounted at a translation stage with a motorized actuator, and a line-slit imaging spectrograph mounted within a rotary assembly with a rear adaptor to a charged-coupled-device (CCD) camera. Push-broom scanning is carried out by the motorized actuator which can be controlled either manually by an operator or automatically by a computer to drive the line-slit across an image at a focal plane of the front objective. To reduce the cost, the system has been designed to integrate as many as possible off-the-shelf components including the CCD camera and spectrograph. The system has achieved high spectral and spatial resolutions by using a high-quality CCD camera, spectrograph, and front objective lens. Fixtures for attachment of the system to a microscope (U.S. Patent 6,495,818 B1) make it possible to acquire multispectral images of single cells and other microscopic objects.

  14. PC based alpha, beta and gamma counting system

    International Nuclear Information System (INIS)

    Bhattacharya, S.; Gopalakrishnan, K.R.; Bairi, B.R.

    1992-01-01

    In the field of radiation protection and safety a large number of samples have to be assayed for estimation of their radioactivity at various stages in nuclear fuel. A PC based alpha, beta and gamma counting system has been designed for the above application. The system is fully automatic and requires minimum of operator intervention. The main units in the system are detector and pulse processing electronics, sample changer and assembly and IBM PC interface and supporting software. The main function of interface is to control the sample changer which is basically loading and unloading of sample, data acquisition and further processing by software. The pulses from detector are analysed in a pulse shape discriminator. A pulse identified as an alpha, beta or gamma event is converted to digital pulse. These digital pulses are accumulated in the three channels on PC interface each corresponding to alpha, beta and gamma. The sample movements are controlled by interface depending upon sample position. The software has been developed so as to maintain user friendliness and convenience of the operator. Various selection modes for parameters and operation of system provide lot of flexibility in operation of the system. (author). 1 fig

  15. Medical imaging systems

    Science.gov (United States)

    Frangioni, John V [Wayland, MA

    2012-07-24

    A medical imaging system provides simultaneous rendering of visible light and fluorescent images. The system may employ dyes in a small-molecule form that remains in a subject's blood stream for several minutes, allowing real-time imaging of the subject's circulatory system superimposed upon a conventional, visible light image of the subject. The system may also employ dyes or other fluorescent substances associated with antibodies, antibody fragments, or ligands that accumulate within a region of diagnostic significance. In one embodiment, the system provides an excitation light source to excite the fluorescent substance and a visible light source for general illumination within the same optical guide that is used to capture images. In another embodiment, the system is configured for use in open surgical procedures by providing an operating area that is closed to ambient light. More broadly, the systems described herein may be used in imaging applications where a visible light image may be usefully supplemented by an image formed from fluorescent emissions from a fluorescent substance that marks areas of functional interest.

  16. Comparison of iodine-123 labelled 2{beta}-carbomethoxy-3{beta}-(4-iodophenyl)tropane and 2{beta}-carbomethoxy-3{beta}-(4-iodophenyl)-N-(3-fluoropropyl)nortropane for imaging of the dopamine transporter in the living human brain

    Energy Technology Data Exchange (ETDEWEB)

    Kuikka, J.T. [Dept. of Clinical Physiology, Kuopio Univ. Hospital (Finland); Bergstroem, K.A. [Dept. of Clinical Physiology, Kuopio Univ. Hospital (Finland); Ahonen, A. [Dept. of Clinical Chemistry, Oulu Univ. Central Hospital (Finland); Hiltunen, J. [MAP Medical Technologies Oy, Tikkakoski (Finland); Haukka, J. [MAP Medical Technologies Oy, Tikkakoski (Finland); Laensimies, E. [Dept. of Clinical Physiology, Kuopio Univ. Hospital (Finland); Wang Shaoyin [Research Biochemicals International (RBI), Natick, MA (United States); Neumeyer, J.L. [Research Biochemicals International (RBI), Natick, MA (United States)

    1995-04-01

    Several cocaine congeners are of potential for imaging the dopamine transporter (DAT). Previous studies have shown that iodine-123 labelled 2{beta}-carbomethoxy-3{beta}-(4-iodophenyl)tropane ([{sup 123}I]{beta}-CIT) is a promising radiotracer for imaging the serotonin (5-HT) and dopamine (DA) transporters in the living human brain with single-photon emission tomography (SPET). [{sup 123}I]{beta}-CIT was found to be not very practical for 1-day DAT imaging protocols since peak DAT uptake occurs later than 8 h. Here we report a pilot comparison of [{sup 123}I]{beta}-CIT and 2{beta}-carbomethoxy-3{beta}-(4-iodophenyl)-N-(3-fluoropropyl)nortropane ([{sup 123}I]{beta}-CIT-FP), using SPET imaging in four healthy male subjects. Peak uptake of [{sup 123}I]{beta}-CIT-FP into the basal ganglia occurred earlier (3-4 h after injection of tracer) than that of [{sup 123}I]{beta}-CIT (>8 h). However, the specific DAT binding of [{sup 123}I]{beta}-CIT-FP in the basal ganglia was somewhat less (0.813{+-}0.047) than that of [{sup 123}I]{beta}-CIT (0.922{+-}0.004). Imaging quality is excellent with both tracers and they are potentially of value for brain imaging in various neuropsychiatric disorders. (orig.)

  17. Quantitative luminescence imaging system

    Science.gov (United States)

    Erwin, David N.; Kiel, Johnathan L.; Batishko, Charles R.; Stahl, Kurt A.

    1990-01-01

    The QLIS images and quantifies low-level chemiluminescent reactions in an electromagnetic field. It is capable of real time nonperturbing measurement and simultaneous recording of many biochemical and chemical reactions such as luminescent immunoassays or enzyme assays. The system comprises image transfer optics, a low-light level digitizing camera with image intensifying microchannel plates, an image process or, and a control computer. The image transfer optics may be a fiber image guide with a bend, or a microscope, to take the light outside of the RF field. Output of the camera is transformed into a localized rate of cumulative digitalized data or enhanced video display or hard-copy images. The system may be used as a luminescent microdosimetry device for radiofrequency or microwave radiation, as a thermal dosimeter, or in the dosimetry of ultra-sound (sonoluminescence) or ionizing radiation. It provides a near-real-time system capable of measuring the extremely low light levels from luminescent reactions in electromagnetic fields in the areas of chemiluminescence assays and thermal microdosimetry, and is capable of near-real-time imaging of the sample to allow spatial distribution analysis of the reaction. It can be used to instrument three distinctly different irradiation configurations, comprising (1) RF waveguide irradiation of a small Petri-dish-shaped sample cell, (2) RF irradiation of samples in a microscope for the microscopie imaging and measurement, and (3) RF irradiation of small to human body-sized samples in an anechoic chamber.

  18. Microculture system for studying monolayers of functional beta-cells.

    Science.gov (United States)

    Dobersen, M J; Scharff, J E; Notkins, A L

    1980-04-01

    A method is described for growing monolayers of newborn rat beta-cells in microculture trays. After disruption of the pancreas with collagenase, islets were isolated by Ficoll density gradient centrifugation, trypsinized to obtain individual cells, and plated in 96-well tissue culture trays. The cells were incubated for the first 3 days in growth medium containing 0.1 mM 3-isobutyl-1-methylxanthine to promote monolayer formation. The cultures could be maintained in a functional state, as defined by their responsiveness to known modulators of insulin secretion, for at least 2 weeks. As few as 1 X 10(3) islet cells/well gave results that were reproducible within +/- 10%. It is suggested that the microculture system for islet cells might prove to be a rapid and reproducible screening technique for studying drugs, viruses, or other agents that affect beta-cell function.

  19. A manual low background alpha beta counting system

    Energy Technology Data Exchange (ETDEWEB)

    Levison, S; German, U; Peled, O; Turgeman, S; Vangrovitz, U; Tirosh, D; Piestum, S; Assido, H [Israel Atomic Energy Commission, Beersheba (Israel). Nuclear Research Center-Negev

    1996-12-01

    An Alpha and Beta counting system consisting of a micro controller-based electronic unit and detectors assembly was developed. The radiation detection unit consists of two proportional detectors (a main detector and a cosmic-ray guard detector) which can be easily disassembled for decontamination or repair. The detectors are mounted in a manual operating sample changer shielded by 5 cm of lead. Simplicity of maintenance and functional operation were taken into consideration in the design. The electronic unit supplies the high voltage and enables the operational functions including controls anti alarms. Calculations of net cpm of Alpha and Beta counting are displayed and can be printed. RS-232 communication option enables connection to a computer and operation of more sophisticated programs for calculations and data storage in the future (authors).

  20. A manual low background alpha beta counting system

    International Nuclear Information System (INIS)

    Levison, S.; German, U.; Peled, O.; Turgeman, S.; Vangrovitz, U.; Tirosh, D.; Piestum, S.; Assido, H.

    1996-01-01

    An Alpha and Beta counting system consisting of a micro controller-based electronic unit and detectors assembly was developed. The radiation detection unit consists of two proportional detectors (a main detector and a cosmic-ray guard detector) which can be easily disassembled for decontamination or repair. The detectors are mounted in a manual operating sample changer shielded by 5 cm of lead. Simplicity of maintenance and functional operation were taken into consideration in the design. The electronic unit supplies the high voltage and enables the operational functions including controls anti alarms. Calculations of net cpm of Alpha and Beta counting are displayed and can be printed. RS-232 communication option enables connection to a computer and operation of more sophisticated programs for calculations and data storage in the future (authors)

  1. Raster images vectorization system

    OpenAIRE

    Genytė, Jurgita

    2006-01-01

    The problem of raster images vectorization was analyzed and researched in this work. Existing vectorization systems are quite expensive, the results are inaccurate, and the manual vectorization of a large number of drafts is impossible. That‘s why our goal was to design and develop a new raster images vectorization system using our suggested automatic vectorization algorithm and the way to record results in a new universal vectorial file format. The work consists of these main parts: analysis...

  2. Scorpion image segmentation system

    Science.gov (United States)

    Joseph, E.; Aibinu, A. M.; Sadiq, B. A.; Bello Salau, H.; Salami, M. J. E.

    2013-12-01

    Death as a result of scorpion sting has been a major public health problem in developing countries. Despite the high rate of death as a result of scorpion sting, little report exists in literature of intelligent device and system for automatic detection of scorpion. This paper proposed a digital image processing approach based on the floresencing characteristics of Scorpion under Ultra-violet (UV) light for automatic detection and identification of scorpion. The acquired UV-based images undergo pre-processing to equalize uneven illumination and colour space channel separation. The extracted channels are then segmented into two non-overlapping classes. It has been observed that simple thresholding of the green channel of the acquired RGB UV-based image is sufficient for segmenting Scorpion from other background components in the acquired image. Two approaches to image segmentation have also been proposed in this work, namely, the simple average segmentation technique and K-means image segmentation. The proposed algorithm has been tested on over 40 UV scorpion images obtained from different part of the world and results obtained show an average accuracy of 97.7% in correctly classifying the pixel into two non-overlapping clusters. The proposed 1system will eliminate the problem associated with some of the existing manual approaches presently in use for scorpion detection.

  3. Beta-gamma counting system for Xe fission products

    International Nuclear Information System (INIS)

    Reeder, P.L.; Bowyer, T.W.; Perkins, R.W.

    1998-01-01

    A beta-gamma coincidence counting system has been developed for automated analysis of Xe gas samples separated from air. The Xe gas samples are contained in a cylindrical plastic scintillator cell located between two NaI(Tl) scintillation detectors. The X-ray and gamma spectra gated by coincident events in the plastic scintillator cell are recorded for each NaI(Tl) crystal. The characteristic signatures of the 131m Xe, 133g Xe, 133m Xe, and 135g Xe isotopes of interest for nuclear test-ban verification as well as the procedures and results of absolute efficiency measurements are described. A NaI(Tl) crystal with provision for 4 sample cells has been implemented for the system to be deployed in the field. Examples of data on ambient air samples in New York City obtained with the field prototype are presented. (author)

  4. Perturbed beta-gamma systems and complex geometry

    Energy Technology Data Exchange (ETDEWEB)

    Zeitlin, Anton M. [Department of Mathematics, Yale University, 442 Dunham Lab, 10 Hillhouse Avenue, New Haven, CT 06511 (United States)], E-mail: anton.zeitlin@yale.edu

    2008-05-11

    We consider the equations, arising as the conformal invariance conditions of the perturbed curved beta-gamma system. These equations have the physical meaning of Einstein equations with a B-field and a dilaton on a Hermitian manifold, where the B-field 2-form is imaginary and proportional to the canonical form associated with Hermitian metric. We show that they decompose into linear and bilinear equations and lead to the vanishing of the first Chern class of the manifold where the system is defined. We discuss the relation of these equations to the generalized Maurer-Cartan structures related to BRST operator. Finally we describe the relations of the generalized Maurer-Cartan bilinear operation and the Courant/Dorfman brackets.

  5. BetaWB - A language for modular representation of biological systems

    DEFF Research Database (Denmark)

    Ihekwaba, Adoha; Larcher, Roberto; Mardare, Radu Iulian

    2007-01-01

    A. Ihekwaba, R. Larcher, R. Mardare, C. Priami. BetaWB - A language for modular representation of biological systems. In Proc. of International Conference on Systems Biology (ICSB), 2007......A. Ihekwaba, R. Larcher, R. Mardare, C. Priami. BetaWB - A language for modular representation of biological systems. In Proc. of International Conference on Systems Biology (ICSB), 2007...

  6. Nuclear imaging system

    International Nuclear Information System (INIS)

    Barrett, H.H.; Horrigan, F.A.

    1975-01-01

    This invention relates to a nuclear imaging system for mapping the source of high energy nuclear particles from a living organ which has selectively absorbed a radioactive compound by spatially coding the energy from the source in a Fresnel pattern on a detector and decoding the detector output to prouce an image of the source. The coding is produced by a Fresnel zone plate interposed between the nuclear energy source and the detector whose position is adjustable with respect to the detector to focus the slices of the nuclear source on the detector. By adjusting the zone plate to a plurality of positions, data from a plurality of cross-sectional slices are produced from which a three-dimensional image of the nuclear source may be obtained. (Patent Office Record)

  7. Radiographic imaging system

    International Nuclear Information System (INIS)

    Davis, L. Jr.; Barrett, H.H.

    1979-01-01

    This invention describes a system for imaging a subject, such as a human being, in which there has been injected a contrast agent which absorbs radiation of a predetermined frequency. The system utilizes a source of high energy radiation such as X or gamma radiation. The source is a composite of first and second radiating materials each of which is arranged in a predetermined pattern or code, each pattern having both luminous and dark regions. In one embodiment, the luminous regions of one pattern are in registration with the dark regions of the other pattern, these regions being spaced apart in an alternative embodiment. The characteristic frequencies of radiation emitted by the first and second materials are respectively lower and higher than the predetermined absorption frequency. A detector of radiation is positioned relative to the subject and the source such that radiation propagating through the subject is incident upon the detector. Since the absorption edge of the contrast agent lies between the two characteristic frequencies of radiation, radiation from the second material is preferentially absorbed by the contrast agent with the result that the contrast agent appears to be illuminated by a coded source while the remainder of the subject may be regarded as illuminated essentially by a uniform uncoded source. Imaging is accomplished by a decoding of a detected coded image. Substances within the subject having other absorption frequencies are not imaged since the radiations of both materials are essentially equally absorbed by the subject so that the source appears uncoded

  8. Energy response of an imaging plate exposed to standard beta sources

    International Nuclear Information System (INIS)

    Gonzalez, A.L.; Li, H.; Mitch, M.; Tolk, N.; Duggan, D.M.

    2002-01-01

    Imaging plates (IPs) are a reusable media, which when exposed to ionizing radiation, store a latent image that can be read out with a red laser as photostimulated luminescence (PSL). They are widely used as a substitute for X-ray films for diagnostic studies. In diagnostic radiology this technology is known as computed radiography. In this work, the energy response of a commercial IP to beta-particle reference radiation fields used for calibrations at the National Institute of Standards and Technology was investigated. The absorbed dose in the active storage phosphor layer was calculated following the scaling procedure for depth dose for high Z materials with reference to water. It was found that the beta particles from Pm-147 and Kr-85 gave 68% and 24% higher PSL responses than that induced by Sr-90, respectively, which was caused by the different PSL detection efficiencies. In addition, normalized response curves of the IPs as a function of depth in polystyrene were measured and compared with the data measured using extrapolation chamber techniques. The difference between both sets of data resulted from the continuous energy change as the beta particle travels across the material, which leads to a different PSL response

  9. The calculation of the detection efficiency in the calibration of gross alpha-beta systems

    International Nuclear Information System (INIS)

    Marian Romeo Calin; Ileana Radulescu; Alexandru Erminiu Druker

    2013-01-01

    This paper presents a method for efficiency calibration of a measuring alpha-beta system PROTEAN ORTEC, MPC-2000-DP, using standard radioactive sources. The system is used to measure gross alpha-beta activity concentrations in environmental samples. The calculated efficiencies of detection were subsequently introduced in the system for two working geometries: measuring geometry-gross alpha-beta ε α g = 31,37 ± 0.25 (%)-the alpha efficiency and ε β g 44.94 ± 0.69 (%)-the beta efficiency, where the spillover factor is X talk g = 25.59 ± 0.50 (%) and measuring geometry up alpha-beta ε α u 36.23 ± 0.29 (%)-the alpha efficiency and ε β u = 48.53 ± 0.74 (%)-the beta efficiency, where the spillover factor is X talk u 31.08 ± 0.60 (%). (author)

  10. Automated Analysis of 123I-beta-CIT SPECT Images with Statistical Probabilistic Anatomical Mapping

    International Nuclear Information System (INIS)

    Eo, Jae Seon; Lee, Hoyoung; Lee, Jae Sung; Kim, Yu Kyung; Jeon, Bumseok; Lee, Dong Soo

    2014-01-01

    Population-based statistical probabilistic anatomical maps have been used to generate probabilistic volumes of interest for analyzing perfusion and metabolic brain imaging. We investigated the feasibility of automated analysis for dopamine transporter images using this technique and evaluated striatal binding potentials in Parkinson's disease and Wilson's disease. We analyzed 2β-Carbomethoxy-3β-(4- 123 I-iodophenyl)tropane ( 123 I-beta-CIT) SPECT images acquired from 26 people with Parkinson's disease (M:F=11:15,mean age=49±12 years), 9 people with Wilson's disease (M: F=6:3, mean age=26±11 years) and 17 normal controls (M:F=5:12, mean age=39±16 years). A SPECT template was created using striatal statistical probabilistic map images. All images were spatially normalized onto the template, and probability-weighted regional counts in striatal structures were estimated. The binding potential was calculated using the ratio of specific and nonspecific binding activities at equilibrium. Voxel-based comparisons between groups were also performed using statistical parametric mapping. Qualitative assessment showed that spatial normalizations of the SPECT images were successful for all images. The striatal binding potentials of participants with Parkinson's disease and Wilson's disease were significantly lower than those of normal controls. Statistical parametric mapping analysis found statistically significant differences only in striatal regions in both disease groups compared to controls. We successfully evaluated the regional 123 I-beta-CIT distribution using the SPECT template and probabilistic map data automatically. This procedure allows an objective and quantitative comparison of the binding potential, which in this case showed a significantly decreased binding potential in the striata of patients with Parkinson's disease or Wilson's disease

  11. Heart Imaging System

    Science.gov (United States)

    1993-01-01

    Johnson Space Flight Center's device to test astronauts' heart function in microgravity has led to the MultiWire Gamma Camera, which images heart conditions six times faster than conventional devices. Dr. Jeffrey Lacy, who developed the technology as a NASA researcher, later formed Proportional Technologies, Inc. to develop a commercially viable process that would enable use of Tantalum-178 (Ta-178), a radio-pharmaceutical. His company supplies the generator for the radioactive Ta-178 to Xenos Medical Systems, which markets the camera. Ta-178 can only be optimally imaged with the camera. Because the body is subjected to it for only nine minutes, the radiation dose is significantly reduced and the technique can be used more frequently. Ta-178 also enables the camera to be used on pediatric patients who are rarely studied with conventional isotopes because of the high radiation dosage.

  12. Beta-endorphin and the immune system--possible role in autoimmune diseases

    DEFF Research Database (Denmark)

    Mørch, H; Pedersen, B K

    1995-01-01

    The immune system and the neuroendocrine system are closely interconnected having such means of bidirectional communication and regulation. In this review, a hypothesis is put forward regarding the possible role of beta-endorphins in the pathogenesis of autoimmune diseases: It is suggested...... that the increased cytokine production in immunoinflammatory disorders induces production of beta-endorphins from the pituitary and the lymphocytes; the enhanced level of beta-endorphin causes inhibition of human T helper cell function, which potentially down-regulate the antibody production. Also the beta......-endorphin-induced enhancement of the natural killer cell activity may suppress the B cell function. In addition, beta-endorphin also exerts a direct inhibitory effect on the antibody production. Thus, in autoimmune disorders the enhanced cytokine level may via stimulation of the production of beta-endorphins exert a negative...

  13. Multi-wavelength imaging of solar plasma. High-beta disruption model of solar flares

    International Nuclear Information System (INIS)

    Shibasaki, Kiyoto

    2007-01-01

    Solar atmosphere is filled with plasma and magnetic field. Activities in the atmosphere are due to plasma instabilities in the magnetic field. To understand the physical mechanisms of activities / instabilities, it is necessary to know the physical conditions of magnetized plasma, such as temperature, density, magnetic field, and their spatial structures and temporal developments. Multi-wavelength imaging is essential for this purpose. Imaging observations of the Sun at microwave, X-ray, EUV and optical ranges are routinely going on. Due to free exchange of original data among solar physics and related field communities, we can easily combine images covering wide range of spectrum. Even under such circumstances, we still do not understand the cause of activities in the solar atmosphere well. The current standard model of solar activities is based on magnetic reconnection: release of stored magnetic energy by reconnection is the cause of solar activities on the Sun such as solar flares. However, recent X-ray, EUV and microwave observations with high spatial and temporal resolution show that dense plasma is involved in activities from the beginning. Based on these observations, I propose a high-beta model of solar activities, which is very similar to high-beta disruptions in magnetically confined fusion experiments. (author)

  14. Cherenkov radiation imaging of beta emitters: in vitro and in vivo results

    International Nuclear Information System (INIS)

    Spinelli, Antonello E.; Boschi, Federico; D'Ambrosio, Daniela; Calderan, Laura; Marengo, Mario; Fenzi, Alberto; Menegazzi, Marta; Sbarbati, Andrea; Del Vecchio, Antonella; Calandrino, Riccardo

    2011-01-01

    The main purpose of this work was to investigate both in vitro and in vivo Cherenkov radiation (CR) emission coming from 18 F and 32 P. The main difference between 18 F and 32 P is mainly the number of the emitted light photons, more precisely the same activity of 32 P emits more CR photons with respect to 18 F. In vitro results obtained by comparing beta counter measurements with photons average radiance showed that Cherenkov luminescence imaging (CLI) allows quantitative tracer activity measurements. In order to investigate in vivo the CLI approach, we studied an experimental xenograft tumor model of mammary carcinoma (BB1 tumor cells). Cherenkov in vivo dynamic whole body images of tumor bearing mice were acquired and the tumor tissue time activity curves reflected the well-known physiological accumulation of 18 F-FDG in malignant tissues with respect to normal tissues. The results presented here show that it is possible to use conventional optical imaging devices for in vitro or in vivo study of beta emitters.

  15. Cherenkov radiation imaging of beta emitters: in vitro and in vivo results

    Energy Technology Data Exchange (ETDEWEB)

    Spinelli, Antonello E., E-mail: spinelli.antonello@hsr.it [Medical Physics Department, S. Raffaele Scientific Institute, Via Olgettina N. 60, Milan (Italy); Boschi, Federico [Department of Morphological-Biomedical Sciences, University of Verona, Strada Le Grazie N. 8, Verona (Italy); D' Ambrosio, Daniela [Medical Physics Department, S. Orsola-Malpighi University Hospital, via Massarenti N. 9, Bologna (Italy); Calderan, Laura [Department of Morphological-Biomedical Sciences, University of Verona, Strada Le Grazie N. 8, Verona (Italy); Marengo, Mario [Medical Physics Department, S. Orsola-Malpighi University Hospital, via Massarenti N. 9, Bologna (Italy); Fenzi, Alberto [Department of Morphological-Biomedical Sciences, University of Verona, Strada Le Grazie N. 8, Verona (Italy); Menegazzi, Marta [Department of Life and Reproduction Sciences, University of Verona, Strada Le Grazie N. 8, Verona (Italy); Sbarbati, Andrea [Department of Morphological-Biomedical Sciences, University of Verona, Strada Le Grazie N. 8, Verona (Italy); Del Vecchio, Antonella; Calandrino, Riccardo [Medical Physics Department, S. Raffaele Scientific Institute, Via Olgettina N. 60, Milan (Italy)

    2011-08-21

    The main purpose of this work was to investigate both in vitro and in vivo Cherenkov radiation (CR) emission coming from {sup 18}F and {sup 32}P. The main difference between {sup 18}F and {sup 32}P is mainly the number of the emitted light photons, more precisely the same activity of {sup 32}P emits more CR photons with respect to {sup 18}F. In vitro results obtained by comparing beta counter measurements with photons average radiance showed that Cherenkov luminescence imaging (CLI) allows quantitative tracer activity measurements. In order to investigate in vivo the CLI approach, we studied an experimental xenograft tumor model of mammary carcinoma (BB1 tumor cells). Cherenkov in vivo dynamic whole body images of tumor bearing mice were acquired and the tumor tissue time activity curves reflected the well-known physiological accumulation of {sup 18}F-FDG in malignant tissues with respect to normal tissues. The results presented here show that it is possible to use conventional optical imaging devices for in vitro or in vivo study of beta emitters.

  16. Tomographic imaging system

    International Nuclear Information System (INIS)

    Hayakawa, T.; Horiba, I.; Kohno, H.; Nakaya, C.; Sekihara, K.; Shiono, H.; Tomura, T.; Yamamoto, S.; Yanaka, S.

    1980-01-01

    A tomographic imaging system comprising: irradiating means for irradating a cross-section of an object under consideration with radiation rays from plural directions; detector means for detecting the radiation rays transmitted through the cross-section of said object to produce an output signal; first memory means for storing the output signal of said detector means; and an image jreconstructing section for performing a convolution integral operation on the contents of said first memory means by means of a first weighting function to reconstruct a three-dimensional image of the cross-section of said object, said image reconstructing section including (I) second memory means for storing a second weighting function, said second weighting function being provided with a predetermined positive and negative (N-1)th order when the output signal of said detector means produced by the irradiation of the cross-section of said object from one of said plural directions is sampled by N points, the value of the (N-1)th order of said second weighting function being an integration of said first weighting function from the (N-1)th order to positive infinity and the value of -(N-1)th order of said second weighting function being an integration of said first weighting function from the -(N-1)th order to negative infinity, (II) control means for successively reading out the contents of said first and second memory means, and (III) operational means for performing multiplying and summing operations on the read-out contents of said first and second memory means, said operational means producing the product of the values fo the (N-1)th and -(N-1)th orders of said second weighting function and a component of the output signal of said detector means relating to the radiation rays free from the absorption thereof by said object

  17. Development of biomarker specific of pancreatic beta cells (incretin radiolabelled) for image of beta functional mass in diabetic and obese: study in animal model

    International Nuclear Information System (INIS)

    Seo, Daniele

    2017-01-01

    Increased prevalence of obesity worldwide, has become a vast concern, stimulating investigations focusing prevention and therapy of this condition. The association of type 2 diabetes or insulin resistance aggravates the prognosis of obesity. Even patients successfully submitted to bariatric or metabolic surgery, may not be cured of diabetes, as improvement of circulating values of glucose and insulin not necessarily reflects recovery of pancreatic beta cell mass. There is no consensus about how to estimate beta cell mass in vivo. Available tools suffer from low sensitivity and specificity, often being as well cumbersome and expensive. Radiolabeled incretins, such as glucagon-like-peptide 1 (GLP-1) analogs, seem to be promising options for the measurement of beta cell mass in diabetes and insulinoma. The objective of this study was the development of two conjugates of GLP-1 analog, radiolabeled with 99m Technetium, as a noninvasive imaging method for the estimation of pancreatic beta cell mass, in the presence of obesity. Animal models were selected, including hyperlipidic diet-induced obesity, diet restricted obesity, and as controls, alloxan diabetes. Results indicated that both radiotracers achieved over 97% radiochemical yield. The most successful product was 99m Tc-HYNIC-βAla-Exendin-4. Low beta cell mass uptake occurred in diet-induced obesity. Diet-restricted obesity, with substantial shedding of excess body weight, was followed by remarkable decrease of fasting blood glucose, however beta cell mass uptake was only mildly improved. Future studies are recommended in obesity, type 2 diabetes, and dieting, including bariatric and metabolic operations. (author)

  18. Systemic lupus erythematosus activity and beta two microglobulin levels

    Directory of Open Access Journals (Sweden)

    Thelma Larocca Skare

    Full Text Available CONTEXT AND OBJECTIVE: Systemic lupus erythematosus (SLE is an autoimmune disease with a cyclical clinical course. Evaluation of the clinical activity of this disease is important for choosing the correct treatment. The objective of this study was to analyze the value of beta-2 microglobulin (β2M serum levels in determining SLE clinical activity.DESIGN AND SETTING: Cross-sectional analytical study conducted at the rheumatology outpatient clinic of a private university hospital.METHODS: 129 SLE patients were studied regarding disease activity using SLEDAI (SLE Disease Activity Index and cumulative damage using SLICC ACR (SLE International Collaborating Clinics/American College of Rheumatology Damage Index for SLE. At the same time, the β2M serum level, ESR (erythrocyte sedimentation rate, anti-dsDNA (anti-double-stranded DNA and C3 and C4 complement fractions were determined.RESULTS: β2M levels correlated positively with SLEDAI (P = 0.02 and ESR (P = 0.0009 and negatively with C3 (P = 0.007. Patients who were positive for anti-dsDNA had higher β2M serum levels (P = 0.009.CONCLUSION: β2M levels are elevated in SLE patients with active disease.

  19. Thyroid status affects the rat cardiac beta-adrenoceptor system transiently and time-dependently

    NARCIS (Netherlands)

    Zwaveling, J.; Batink, H. D.; Taguchi, K.; de Jong, J.; Michel, M. C.; Pfaffendorf, M.; van Zwieten, A.

    1998-01-01

    1. The aim of this study was to investigate the time-dependency of the influence of dysthyroid states on the beta-adrenoceptor system in rat heart left ventricle. Therefore, the influence of acute and chronic hyper- and hypothyroidism on beta-adrenoceptor-induced left ventricular responses,

  20. Acoustic imaging system

    Science.gov (United States)

    Smith, Richard W.

    1979-01-01

    An acoustic imaging system for displaying an object viewed by a moving array of transducers as the array is pivoted about a fixed point within a given plane. A plurality of transducers are fixedly positioned and equally spaced within a laterally extending array and operatively directed to transmit and receive acoustic signals along substantially parallel transmission paths. The transducers are sequentially activated along the array to transmit and receive acoustic signals according to a preestablished sequence. Means are provided for generating output voltages for each reception of an acoustic signal, corresponding to the coordinate position of the object viewed as the array is pivoted. Receptions from each of the transducers are presented on the same display at coordinates corresponding to the actual position of the object viewed to form a plane view of the object scanned.

  1. Nuclear medicine imaging system

    Science.gov (United States)

    Bennett, Gerald W.; Brill, A. Bertrand; Bizais, Yves J. C.; Rowe, R. Wanda; Zubal, I. George

    1986-01-01

    A nuclear medicine imaging system having two large field of view scintillation cameras mounted on a rotatable gantry and being movable diametrically toward or away from each other is disclosed. In addition, each camera may be rotated about an axis perpendicular to the diameter of the gantry. The movement of the cameras allows the system to be used for a variety of studies, including positron annihilation, and conventional single photon emission, as well as static orthogonal dual multi-pinhole tomography. In orthogonal dual multi-pinhole tomography, each camera is fitted with a seven pinhole collimator to provide seven views from slightly different perspectives. By using two cameras at an angle to each other, improved sensitivity and depth resolution is achieved. The computer system and interface acquires and stores a broad range of information in list mode, including patient physiological data, energy data over the full range detected by the cameras, and the camera position. The list mode acquisition permits the study of attenuation as a result of Compton scatter, as well as studies involving the isolation and correlation of energy with a range of physiological conditions.

  2. Experimental image alignment system

    Science.gov (United States)

    Moyer, A. L.; Kowel, S. T.; Kornreich, P. G.

    1980-01-01

    A microcomputer-based instrument for image alignment with respect to a reference image is described which uses the DEFT sensor (Direct Electronic Fourier Transform) for image sensing and preprocessing. The instrument alignment algorithm which uses the two-dimensional Fourier transform as input is also described. It generates signals used to steer the stage carrying the test image into the correct orientation. This algorithm has computational advantages over algorithms which use image intensity data as input and is suitable for a microcomputer-based instrument since the two-dimensional Fourier transform is provided by the DEFT sensor.

  3. Alpha–beta monitoring system based on pair of simultaneous Multi-Wire Proportional Counters

    Energy Technology Data Exchange (ETDEWEB)

    Wengrowicz, U.; Amidan, D. [Department of Nuclear Engineering, Ben Gurion University of the Negev, Beer-Sheva 84105 (Israel); NRC-Negev, P.O. Box 9001, Beer-Sheva 84190 (Israel); Orion, I. [Department of Nuclear Engineering, Ben Gurion University of the Negev, Beer-Sheva 84105 (Israel)

    2016-08-11

    A new approach for a simultaneous alpha–beta Multi-wire Proportional Counter (MWPC) is presented. The popular approach for alpha–beta monitoring systems consists of a large area MWPC using noble gas flow such as Argon Methane. This method of measurement is effective but requires large-scale and expensive maintenance due to the needs of gas flow control and periodic replacements. In this work, a pair of simultaneous MWPCs for alpha–beta measuring is presented. The developed detector consists of a sealed gas MWPC sensor for beta particles, behind a free air alpha sensor. This approach allows effective simultaneous detection and discrimination of both alpha and beta radiation without the maintenance cost noble gas flow required for unsealed detectors.

  4. OSPACS: Ultrasound image management system

    Directory of Open Access Journals (Sweden)

    Bessant Conrad

    2008-06-01

    Full Text Available Abstract Background Ultrasound scanning uses the medical imaging format, DICOM, for electronically storing the images and data associated with a particular scan. Large health care facilities typically use a picture archiving and communication system (PACS for storing and retrieving such images. However, these systems are usually not suitable for managing large collections of anonymized ultrasound images gathered during a clinical screening trial. Results We have developed a system enabling the accurate archiving and management of ultrasound images gathered during a clinical screening trial. It is based upon a Windows application utilizing an open-source DICOM image viewer and a relational database. The system automates the bulk import of DICOM files from removable media by cross-validating the patient information against an external database, anonymizing the data as well as the image, and then storing the contents of the file as a field in a database record. These image records may then be retrieved from the database and presented in a tree-view control so that the user can select particular images for display in a DICOM viewer or export them to external media. Conclusion This system provides error-free automation of ultrasound image archiving and management, suitable for use in a clinical trial. An open-source project has been established to promote continued development of the system.

  5. Central nervous system imaging

    International Nuclear Information System (INIS)

    Anon.

    1987-01-01

    Since its introduction in 1973, computed tomography (CT) of the brain has had a revolutionary impact on neuroradiologic diagnosis. It has largely replaced radionuclide brain imaging as the initial, noninvasive neurologic screening examination. Although conventional radionuclide brain imaging still contributes useful and unique diagnostic information in a few clinical situations, it appears that new technology and applications must be found if nuclear imaging is to play a prominent future role in neurologic diagnosis as it did in the past. One of the main advantages of CT over radionuclide brain imaging at present is CT's ability to demonstrate the size, shape, and position of the cerebral ventricles and subarachnoid spaces. Another important strength of CT is the ability to differentiate ischemic cerebral infarction from intracerebral hemorrhage. The overall sensitivity of CT in detecting intracranial neoplasms is also greater than that of radionuclide brain imaging, and CT is very useful in demonstrating the effects of head trauma. Magnetic resonance imaging appears superior to CT in the evaluation of neurologic disorders. A renewed interest in radionuclide brain imaging has developed because of recent advances in emission computed tomographic imaging. When tracer kinetic models are used, cerebral blood flow (CBF), blood volume, metabolic rate, and glucose and amino acid transport can be measured. Other applications involve investigation of receptor bindings, evaluation of the blood-brain barrier, brain blood-volume measurement, and cisternography

  6. Spatially modulated imaging system

    International Nuclear Information System (INIS)

    Barrett, H.H.

    1975-01-01

    Noncoherent radiation, such as x-rays, is spatially coded, directed through an object and spatially detected to form a spatially coded pattern, from which an image of the object may be reconstructed. The x-ray source may be formed by x-ray fluorescence and substration of the holographic images formed by two sources having energy levels predominantly above and below the maximum absorption range of an agent in the object may be used to enhance contrast in the reproduced image. (Patent Office Record)

  7. New image-stabilizing system

    Science.gov (United States)

    Zhao, Yuejin

    1996-06-01

    In this paper, a new method for image stabilization with a three-axis image- stabilizing reflecting prism assembly is presented, and the principle of image stabilization in this prism assembly, formulae for image stabilization and working formulae with an approximation up to the third power are given in detail. In this image-stabilizing system, a single chip microcomputer is used to calculate value of compensating angles and thus to control the prism assembly. Two gyroscopes act as sensors from which information of angular perturbation is obtained, three stepping motors drive the prism assembly to compensate for the movement of image produced by angular perturbation. The image-stabilizing device so established is a multifold system which involves optics, mechanics, electronics and computer.

  8. Production measurements on the quadrupole correctors for the new Low- Beta System for the Tevatron Collider

    International Nuclear Information System (INIS)

    Mokhtarani, A.; Brown, B.C.; Hanft, R.; Oleck, A.R.; Peterson, T.; Turkot, F.

    1991-05-01

    Each of the Low Beta Systems for the Tevatron Collider requires 12 spool pieces; eight of the spool pieces contain superconducting quadrupoles as part of the low beta insertion as well as standard correction magnets. The remaining four provide correction magnets, beam position monitors, and current feeds for the neighboring low beta main quadrupoles. Thirty-two of these new spools have been fabricated. We describe here the mechanical, cryogenic and magnetic properties of these new spools as determined in the production test and measurement activities. 8 refs., 7 figs., 1 tab

  9. Mechanics of bioinspired imaging systems

    Directory of Open Access Journals (Sweden)

    Zhengwei Li

    2016-01-01

    Full Text Available Imaging systems in nature have attracted a lot of research interest due to their superior optical and imaging characteristics. Recent advancements in materials science, mechanics, and stretchable electronics have led to successful development of bioinspired cameras that resemble the structures and functions of biological light-sensing organs. In this review, we discuss some recent progresses in mechanics of bioinspired imaging systems, including tunable hemispherical eyeball camera and artificial compound eye camera. The mechanics models and results reviewed in this article can provide efficient tools for design and optimization of such systems, as well as other related optoelectronic systems that combine rigid elements with soft substrates.

  10. Army medical imaging system: ARMIS

    International Nuclear Information System (INIS)

    Siedband, M.P.; Kramp, D.C.

    1987-01-01

    Recent advances of stimulable phosphor screens, data cards using optical storage means, and new personal computers with image processing capability have made possible the design of economical filmless medical imaging systems. The addition of communication links means that remote interpretation of images is also possible. The Army Medical Imaging System uses stimulable phosphor screens, digital readout, a small computer, an optical digital data card device, and a DIN/PACS link. Up to 200 images can be stored in the computer hard disk for rapid recall and reading by the radiologist. The computer permits image processing, annotation, insertion of text, and control of the system. Each device contains an image storage RAM and communicates with the computer via the small computer systems interface. Data compression is used to reduce the required storage capacity and transmission times of the 1-mB images. The credit card-size optical data cards replace film and can store 12 or more images. The data cards can be read on an independent viewer. The research is supported by the U.S. Army Biomedical Research and Development Laboratory

  11. Imaging with PET system

    International Nuclear Information System (INIS)

    Das, B.K.; Noreen Norfaraheen Lee Abdullah

    2012-01-01

    PET deals with biochemistry and metabolic changes that occur at molecular level. Hence, PET differs fundamentally from other imaging modalities. CT imaging is based on tissue density, whereas MRI conveys anatomic information based on proton density and proton relaxation dynamics. CT and MRI are useful in clinical diagnosis only when disease process has caused significant anatomic alterations. However, in most disease conditions chemical changes precede anatomic changes, that can be detected by PET technology. Thus, PET can provide earliest and unique information about ongoing disease process long before anatomic or structural changes take place. There is no other modality available at present that can replace PET technology. Although PET produces cross-sectional images like that obtained in MRI or CT, they represent circulation, function and metabolism, and not anatomic structure. PET is extremely sensitive measuring quantitatively concentration of tracers in nano to pico-molar range. Thus, PET enables merger of biochemistry and biology in medicine giving birth to molecular medicine that focuses on identifying the molecular errors of disease leading to developing molecular corrections including gene therapy. Molecular imaging with PET has been playing a role in examining the biological nature of a disease condition and its characterization to guide selection and evaluation of treatment. (author)

  12. Demonstration of Single-Barium-Ion Sensitivity for Neutrinoless Double-Beta Decay Using Single-Molecule Fluorescence Imaging

    Science.gov (United States)

    McDonald, A. D.; Jones, B. J. P.; Nygren, D. R.; Adams, C.; Álvarez, V.; Azevedo, C. D. R.; Benlloch-Rodríguez, J. M.; Borges, F. I. G. M.; Botas, A.; Cárcel, S.; Carrión, J. V.; Cebrián, S.; Conde, C. A. N.; Díaz, J.; Diesburg, M.; Escada, J.; Esteve, R.; Felkai, R.; Fernandes, L. M. P.; Ferrario, P.; Ferreira, A. L.; Freitas, E. D. C.; Goldschmidt, A.; Gómez-Cadenas, J. J.; González-Díaz, D.; Gutiérrez, R. M.; Guenette, R.; Hafidi, K.; Hauptman, J.; Henriques, C. A. O.; Hernandez, A. I.; Hernando Morata, J. A.; Herrero, V.; Johnston, S.; Labarga, L.; Laing, A.; Lebrun, P.; Liubarsky, I.; López-March, N.; Losada, M.; Martín-Albo, J.; Martínez-Lema, G.; Martínez, A.; Monrabal, F.; Monteiro, C. M. B.; Mora, F. J.; Moutinho, L. M.; Muñoz Vidal, J.; Musti, M.; Nebot-Guinot, M.; Novella, P.; Palmeiro, B.; Para, A.; Pérez, J.; Querol, M.; Repond, J.; Renner, J.; Riordan, S.; Ripoll, L.; Rodríguez, J.; Rogers, L.; Santos, F. P.; dos Santos, J. M. F.; Simón, A.; Sofka, C.; Sorel, M.; Stiegler, T.; Toledo, J. F.; Torrent, J.; Tsamalaidze, Z.; Veloso, J. F. C. A.; Webb, R.; White, J. T.; Yahlali, N.; NEXT Collaboration

    2018-03-01

    A new method to tag the barium daughter in the double-beta decay of Xe 136 is reported. Using the technique of single molecule fluorescent imaging (SMFI), individual barium dication (Ba++ ) resolution at a transparent scanning surface is demonstrated. A single-step photobleach confirms the single ion interpretation. Individual ions are localized with superresolution (˜2 nm ), and detected with a statistical significance of 12.9 σ over backgrounds. This lays the foundation for a new and potentially background-free neutrinoless double-beta decay technology, based on SMFI coupled to high pressure xenon gas time projection chambers.

  13. Demonstration of Single-Barium-Ion Sensitivity for Neutrinoless Double-Beta Decay Using Single-Molecule Fluorescence Imaging

    Energy Technology Data Exchange (ETDEWEB)

    McDonald, A. D.; Jones, B. J. P.; Nygren, D. R.; Adams, C.; Álvarez, V.; Azevedo, C. D. R.; Benlloch-Rodríguez, J. M.; Borges, F. I. G. M.; Botas, A.; Cárcel, S.; Carrión, J. V.; Cebrián, S.; Conde, C. A. N.; Díaz, J.; Diesburg, M.; Escada, J.; Esteve, R.; Felkai, R.; Fernandes, L. M. P.; Ferrario, P.; Ferreira, A. L.; Freitas, E. D. C.; Goldschmidt, A.; Gómez-Cadenas, J. J.; González-Díaz, D.; Gutiérrez, R. M.; Guenette, R.; Hafidi, K.; Hauptman, J.; Henriques, C. A. O.; Hernandez, A. I.; Hernando Morata, J. A.; Herrero, V.; Johnston, S.; Labarga, L.; Laing, A.; Lebrun, P.; Liubarsky, I.; López-March, N.; Losada, M.; Martín-Albo, J.; Martínez-Lema, G.; Martínez, A.; Monrabal, F.; Monteiro, C. M. B.; Mora, F. J.; Moutinho, L. M.; Muñoz Vidal, J.; Musti, M.; Nebot-Guinot, M.; Novella, P.; Palmeiro, B.; Para, A.; Pérez, J.; Querol, M.; Repond, J.; Renner, J.; Riordan, S.; Ripoll, L.; Rodríguez, J.; Rogers, L.; Santos, F. P.; dos Santos, J. M. F.; Simón, A.; Sofka, C.; Sorel, M.; Stiegler, T.; Toledo, J. F.; Torrent, J.; Tsamalaidze, Z.; Veloso, J. F. C. A.; Webb, R.; White, J. T.; Yahlali, N.

    2018-03-01

    A new method to tag the barium daughter in the double beta decay of $^{136}$Xe is reported. Using the technique of single molecule fluorescent imaging (SMFI), individual barium dication (Ba$^{++}$) resolution at a transparent scanning surface has been demonstrated. A single-step photo-bleach confirms the single ion interpretation. Individual ions are localized with super-resolution ($\\sim$2~nm), and detected with a statistical significance of 12.9~$\\sigma$ over backgrounds. This lays the foundation for a new and potentially background-free neutrinoless double beta decay technology, based on SMFI coupled to high pressure xenon gas time projection chambers.

  14. Underwater laser imaging system (UWLIS)

    Energy Technology Data Exchange (ETDEWEB)

    DeLong, M. [Lawrence Livermore National Lab., CA (United States)

    1994-11-15

    Practical limitations with underwater imaging systems area reached when the noise in the back scattered radiation generated in the water between the imaging system and the target obscures the spatial contrast and resolution necessary for target discovery and identification. The advent of high power lasers operating in the blue-green portion of the visible spectrum (oceanic transmission window) has led to improved experimental illumination systems for underwater imaging. Range-gated and synchronously scanned devices take advantage of the unique temporal and spatial coherence properties of laser radiation, respectively, to overcome the deleterious effects of common volume back scatter.

  15. A detection system for very low-energy protons from {beta}-delayed proton decay

    Energy Technology Data Exchange (ETDEWEB)

    Spiridon, A.; Pollacco, E.; Trache, L.; Simmons, E.; McCleskey, M.; Roeder, B. T.; Tribble, R. E.; Pascovici, G.; Riallot, M.; Mols, J. P.; Kebbiri, M. [Cyclotron Institute, Texas A and M University, College Station, TX 77843-3366 (United States); CEA/IRFU Saclay, Gif-sur-Yvette (France); Cyclotron Institute, Texas A and M University, College Station, TX 77843-3366 (United States); Institut fuer Kernphysik der Universitaet zu Koeln, D-50937 Koeln (Germany); CEA/IRFU Saclay, Gif-sur-Yvette (France)

    2012-11-20

    We have recently developed a gas based detection system called AstroBox, motivated by nuclear astrophysics studies. The goal was to detect very low-energy protons from {beta}-delayed p-decay with reduced beta background and improved energy resolution. The detector was tested using the {beta}-delayed proton-emitter 23Al previously studied with a set-up based on thin double-sided Si strip detectors. The proton spectrum obtained with AstroBox showed no beta background down to {approx}80 keV. The low energy (206 keV, 267 keV) proton peaks were positively identified, well separated, and the resolution was improved.

  16. Equilibrium of high beta plasma in closed magnetic line system (MBT)

    International Nuclear Information System (INIS)

    Gesso, H.; Shiina, S.; Saito, K.; Nogi, Y.; Osaniai, Y.; Yoshimura, H.; Todoroki, J.; Hamada, S.; Nihon Univ., Tokyo. Atomic Energy Research Inst.)

    1985-01-01

    The beta effects on the plasma equilibrium in Modified Bumpy Torus (MBT) sector, which is an asymmetric closed line system with l = 0 and fairly large l = +- 1 field distortions, are studied. For this purpose, the equilibrium of high beta plasma produced by theta-pinch is compared with that of betaless plasma numerically calculated from the measured magnetic field profiles in device. The equilibrium condition depends weakly on beta value, but the plasma cross-section is vertically elongated as the beta value increases. The m = 1 long wavelength MHD instability is not observed during the observation time of approx. 15 μs. These experimental results are compared with MHD theory based on the new ordering taking the finiteness of l = +- 1 field distortion (deltasub(+-1) > or approx. 1) into account, which suggests significant stabilizing effects due to self formation of magnetic well and also due to the conducting wall. (author)

  17. Performance assessment of imaging plates for the JHR transfer Neutron Imaging System

    Science.gov (United States)

    Simon, E.; Guimbal, P. AB(; )

    2018-01-01

    The underwater Neutron Imaging System to be installed in the Jules Horowitz Reactor (JHR-NIS) is based on a transfer method using a neutron activated beta-emitter like Dysprosium. The information stored in the converter is to be offline transferred on a specific imaging system, still to be defined. Solutions are currently under investigation for the JHR-NIS in order to anticipate the disappearance of radiographic films commonly used in these applications. We report here the performance assessment of Computed Radiography imagers (Imaging Plates) performed at LLB/Orphée (CEA Saclay). Several imaging plate types are studied, in one hand in the configuration involving an intimate contact with an activated dysprosium foil converter: Fuji BAS-TR, Fuji UR-1 and Carestream Flex XL Blue imaging plates, and in the other hand by using a prototypal imaging plate doped with dysprosium and thus not needing any contact with a separate converter foil. The results for these imaging plates are compared with those obtained with gadolinium doped imaging plate used in direct neutron imaging (Fuji BAS-ND). The detection performances of the different imagers are compared regarding resolution and noise. The many advantages of using imaging plates over radiographic films (high sensitivity, linear response, high dynamic range) could palliate its lower intrinsic resolution.

  18. Stereoscopic medical imaging collaboration system

    Science.gov (United States)

    Okuyama, Fumio; Hirano, Takenori; Nakabayasi, Yuusuke; Minoura, Hirohito; Tsuruoka, Shinji

    2007-02-01

    The computerization of the clinical record and the realization of the multimedia have brought improvement of the medical service in medical facilities. It is very important for the patients to obtain comprehensible informed consent. Therefore, the doctor should plainly explain the purpose and the content of the diagnoses and treatments for the patient. We propose and design a Telemedicine Imaging Collaboration System which presents a three dimensional medical image as X-ray CT, MRI with stereoscopic image by using virtual common information space and operating the image from a remote location. This system is composed of two personal computers, two 15 inches stereoscopic parallax barrier type LCD display (LL-151D, Sharp), one 1Gbps router and 1000base LAN cables. The software is composed of a DICOM format data transfer program, an operation program of the images, the communication program between two personal computers and a real time rendering program. Two identical images of 512×768 pixcels are displayed on two stereoscopic LCD display, and both images show an expansion, reduction by mouse operation. This system can offer a comprehensible three-dimensional image of the diseased part. Therefore, the doctor and the patient can easily understand it, depending on their needs.

  19. Metrological characteristics of the new BSS2 beta secondary standard system

    International Nuclear Information System (INIS)

    Reynaldo, Sibele R.

    2005-01-01

    Due to the increased interest and the importance of beta radiation dosimetry for radiation protection purposes, the Centro de Desenvolvimento da Tecnologia Nuclear. MG, Brazil, acquired the newest Beta Secondary Standard system (BSS2) in order to replace the old BSS1 model, with the goal of implement a beta radiation metrology laboratory and provide the corresponding reference radiation. The new system BSS2, unique in Latin America, requires operational testing and metrological characterization for reliability purposes. For this, some comparative investigations of the two systems were made. The influence of opening and closing the shutter in the final dose of radiation was identified as the highest in the BSS2 in relation to the one founded in BSS1, justified by the structural difference of the shutters of the systems and the reproducibility of source-detector geometry was better in BSS2, because of the robustness of the same

  20. Beta-irradiation used for systemic radioimmunotherapy induces apoptosis and activates apoptosis pathways in leukaemia cells

    International Nuclear Information System (INIS)

    Friesen, Claudia; Lubatschofski, Annelie; Debatin, Klaus-Michael; Kotzerke, Joerg; Buchmann, Inga; Reske, Sven N.

    2003-01-01

    Beta-irradiation used for systemic radioimmunotherapy (RIT) is a promising treatment approach for high-risk leukaemia and lymphoma. In bone marrow-selective radioimmunotherapy, beta-irradiation is applied using iodine-131, yttrium-90 or rhenium-188 labelled radioimmunoconjugates. However, the mechanisms by which beta-irradiation induces cell death are not understood at the molecular level. Here, we report that beta-irradiation induced apoptosis and activated apoptosis pathways in leukaemia cells depending on doses, time points and dose rates. After beta-irradiation, upregulation of CD95 ligand and CD95 receptor was detected and activation of caspases resulting in apoptosis was found. These effects were completely blocked by the broad-range caspase inhibitor zVAD-fmk. In addition, irradiation-mediated mitochondrial damage resulted in perturbation of mitochondrial membrane potential, caspase-9 activation and cytochrome c release. Bax, a death-promoting protein, was upregulated and Bcl-x L , a death-inhibiting protein, was downregulated. We also found higher apoptosis rates and earlier activation of apoptosis pathways after gamma-irradiation in comparison to beta-irradiation at the same dose rate. Furthermore, irradiation-resistant cells were cross-resistant to CD95 and CD95-resistant cells were cross-resistant to irradiation, indicating that CD95 and irradiation used, at least in part, identical effector pathways. These findings demonstrate that beta-irradiation induces apoptosis and activates apoptosis pathways in leukaemia cells using both mitochondrial and death receptor pathways. Understanding the timing, sequence and molecular pathways of beta-irradiation-mediated apoptosis may allow rational adjustment of chemo- and radiotherapeutic strategies. (orig.)

  1. Artificial intelligence and medical imaging. Expert systems and image analysis

    International Nuclear Information System (INIS)

    Wackenheim, A.; Zoellner, G.; Horviller, S.; Jacqmain, T.

    1987-01-01

    This paper gives an overview on the existing systems for automated image analysis and interpretation in medical imaging, especially in radiology. The example of ORFEVRE, the system for the analysis of CAT-scan images of the cervical triplet (c3-c5) by image analysis and subsequent expert-system is given and discussed in detail. Possible extensions are described [fr

  2. A Diagnostic Ultrasound Imaging System

    International Nuclear Information System (INIS)

    Lee, Seong Woo

    1999-01-01

    The ability to see the internal organs of the human body in a noninvasive way is a powerful diagnostic tool of modern medicine. Among these imaging modalities such as X-ray, MRI, and ultrasound. MRI and ultrasound are presenting much less risk of undesirable damage of both patient and examiner. In fact, no deleterious effects have been reported as a result of clinical examination by using MRI and ultrasound diagnostic equipment. As a result, their market volume has been rapidly increased. MRI has a good resolution. but there are a few disadvantages such as high price. non-real-time imaging capability. and expensive diagnostic cost. On the other hand, the ultrasound imaging system has inherently poor resolution as compared with X-ray and MRI. In spite of its poor resolution, the ultrasound diagnostic equipment is lower in price and has an ability of real-time imaging as compared with the others. As a result, the ultrasound imaging system has become general and essential modality for imaging the internal organs of human body. In this review various researches and developments to enhance the resolution of the ultrasound images are explained and future trends of the ultrasound imaging technology are described

  3. Implantation of a new Beta Secondary Standard system at Centro de Desenvolvimento da Tecnologia Nuclear

    International Nuclear Information System (INIS)

    Reynaldo, Sibele Reis

    2005-01-01

    The crescent use of beta radiation sources in medical, industrial and research applications has increased the need for higher accuracy in beta dosimetry. As the first Beta Secondary Standard system (BSS1) was developed about 20 years ago, a new BSS2 system was made commercially available to fulfill new metrological demands and to follow the technological development. The BSS2 has a new positioning set-up, high activity and long half-life beta radiation sources and a special safety system. The Centro de Desenvolvimento da Tecnologia Nuclear is the first laboratory in Latin America that has got a BSS2. This work describes the BSS2 and it compares its advantages in relation to BSS1; results of the beam uniformity tests of the radiation fields from 90 Sr/ 90 Y, 85 Kr and 147 Pm sources, that were measured with an ionization chamber and with thermoluminescent detectors, are also shown. Results show that the beta radiation fields are considered to be uniform for diameters between 8 and 20 cm according to the chosen source. (author)

  4. Microprocessor based image processing system

    International Nuclear Information System (INIS)

    Mirza, M.I.; Siddiqui, M.N.; Rangoonwala, A.

    1987-01-01

    Rapid developments in the production of integrated circuits and introduction of sophisticated 8,16 and now 32 bit microprocessor based computers, have set new trends in computer applications. Nowadays the users by investing much less money can make optimal use of smaller systems by getting them custom-tailored according to their requirements. During the past decade there have been great advancements in the field of computer Graphics and consequently, 'Image Processing' has emerged as a separate independent field. Image Processing is being used in a number of disciplines. In the Medical Sciences, it is used to construct pseudo color images from computer aided tomography (CAT) or positron emission tomography (PET) scanners. Art, advertising and publishing people use pseudo colours in pursuit of more effective graphics. Structural engineers use Image Processing to examine weld X-rays to search for imperfections. Photographers use Image Processing for various enhancements which are difficult to achieve in a conventional dark room. (author)

  5. An XCT image database system

    International Nuclear Information System (INIS)

    Komori, Masaru; Minato, Kotaro; Koide, Harutoshi; Hirakawa, Akina; Nakano, Yoshihisa; Itoh, Harumi; Torizuka, Kanji; Yamasaki, Tetsuo; Kuwahara, Michiyoshi.

    1984-01-01

    In this paper, an expansion of X-ray CT (XCT) examination history database to XCT image database is discussed. The XCT examination history database has been constructed and used for daily examination and investigation in our hospital. This database consists of alpha-numeric information (locations, diagnosis and so on) of more than 15,000 cases, and for some of them, we add tree structured image data which has a flexibility for various types of image data. This database system is written by MUMPS database manipulation language. (author)

  6. High intensity radiation imaging system

    International Nuclear Information System (INIS)

    Barrett, H.H.

    1976-01-01

    A nuclear imaging system is described for mapping a spatially distributed source of high energy nuclear particles from a living organ which has selectively absorbed a radioactive compound in which the nuclear energy is spatially coded by a zone plate positioned between the source and a spatial detector, and a half tone screen is positioned between the source and the zone plate to increase the definition of the image

  7. {beta}-{gamma} systems and the deformations of the BRST operator

    Energy Technology Data Exchange (ETDEWEB)

    Zeitlin, Anton M [Department of Mathematics, Yale University, 442 Dunham Lab, 10 Hillhouse Ave, New Haven, CT 06511 (United States)], E-mail: anton.zeitlin@yale.edu

    2009-09-04

    We describe the relation between simple logarithmic CFTs associated with closed and open strings, and their 'infinite metric' limits, corresponding to the {beta}-{gamma} systems. This relation is studied on the level of the BRST complex: we show that the consideration of metric as a perturbation leads to a certain deformation of the algebraic operations of the Lian-Zuckerman type on the vertex algebra, associated with the {beta}-{gamma} systems. The Maurer-Cartan equations corresponding to this deformed structure in the quasi-classical approximation lead to the nonlinear field equations. As an explicit example, we demonstrate that using this construction, Yang-Mills equations can be derived. This gives rise to a nontrivial relation between the Courant-Dorfman algebroid and homotopy algebras emerging from the gauge theory. We also discuss a possible algebraic approach to the study of beta-functions in sigma-models.

  8. Stepped scanner radiographic imaging system

    International Nuclear Information System (INIS)

    Lapidus, S.N.

    1981-01-01

    The imaging system includes a radiographic camera, a bed for supporting a subject in view of the camera, and a display system. The camera provides X and Y coordinate signals of each radiographic event. The position of the bed relative to the camera is altered sequentially by drive means, between each of a sequence of images provided by the camera. The sequentially occurring images are presented on the display system, each image being positioned on the display in correspondence with the location of the bed relative to the camera. The coordinates of each image point presented on the display is equal to the sum of the respective X and Y coordinate signals from the camera with X and Y coordinate signals provided by a timer which controls the drive means and defines the location of the bed relative to the camera. The camera is electronically decoupled from the display by a gate during movement of the bed relative to the camera from one location to the next location to prevent any smearing effect within the composite image presented on the display. (author)

  9. The pancreas in {beta}-thalassemia major: MR imaging features and correlation with iron stores and glucose disturbunces

    Energy Technology Data Exchange (ETDEWEB)

    Papakonstantinou, Olympia [University Hospital of Heraklion, Medical School of Crete, Department of Radiology, Heraklion, Crete (Greece); Attikon Hospital, 2nd Department of Radiology, Athens (Greece); Ladis, Vasilios; Kostaridou, Stavroula; Berdousi, Helen; Kattamis, Christos [Thalassemia Unit, University of Athens, ' ' Aghia Sophia' ' Children' s Hospital, Athens (Greece); Maris, Thomas; Gourtsoyiannis, Nicholas [University Hospital of Heraklion, Medical School of Crete, Department of Radiology, Heraklion, Crete (Greece)

    2007-06-15

    The study aims at describing the MR features of pancreas in beta-thalassemia major, investigating the relations between MR findings and glucose disturbances and between hepatic and pancreatic siderosis. Signal intensity ratios of the pancreas and liver to right paraspinous muscle (P/M, L/M) were retrospectively assessed on abdominal MR imaging studies of 31 transfusion-dependent patients with beta-thalassemia major undergoing quantification of hepatic siderosis and 10 healthy controls, using T1- (120/4/90), intermediate in and out of phase - (120/2.7, 4/20), and T2*-(120/15/20) weighted GRE sequences. Using the signal drop of the liver and pancreas on opposed phase images, we recorded serum ferritin and results of oral glucose tolerance test (OGTT). Decreased L/M and P/M on at least the T2* sequence were noticed in 31/31 and 30/31 patients, respectively, but no correlation between P/M and L/M was found. Patients with pathologic OGTT displayed a higher degree of hepatic siderosis (p < 0.04) and signal drop of pancreas on opposed phase imaging (p < 0.025), implying fatty replacement of pancreas. P/M was neither correlated with glucose disturbances nor serum ferritin. Iron deposition in the pancreas cannot be predicted by the degree of hepatic siderosis in beta-thalassemia major. Fatty replacement of the pancreas is common and may be associated with glucose disturbances. (orig.)

  10. A Combined Very Large Telescope and Gemini Study of the Atmosphere of the Directly Imaged Planet, Beta Pictoris b

    Science.gov (United States)

    Currie, Thayne; Burrows, Adam; Madhusudhan, Nikku; Fukagawa, Misato; Girard, Julien H.; Dawson, Rebekah; Murray-Clay, Ruth; Kenyon, Scott; Kuchner, Marc J.; Matsumura, Soko; hide

    2013-01-01

    We analyze new/archival VLT/NaCo and Gemini/NICI high-contrast imaging of the young, self-luminous planet Beta Pictoris b in seven near-to-mid IR photometric filters, using advanced image processing methods to achieve high signal-to-noise, high precision measurements. While Beta Pic b's near-IR colors mimic those of a standard, cloudy early-to-mid L dwarf, it is overluminous in the mid-infrared compared to the field L/T dwarf sequence. Few substellar/planet-mass objects-i.e., ? And b and 1RXJ 1609B-match Beta Pic b's JHKsL photometry and its 3.1 micron and 5 micron photometry are particularly difficult to reproduce. Atmosphere models adopting cloud prescriptions and large (approx. 60 micron)dust grains fail to reproduce the Beta Pic b spectrum. However, models incorporating thick clouds similar to those found forHR8799 bcde, but also with small (a fewmicrons) modal particle sizes, yield fits consistent with the data within the uncertainties. Assuming solar abundance models, thick clouds, and small dust particles (a = 4 micron), we derive atmosphere parameters of log(g) = 3.8 +/- 0.2 and Teff = 1575-1650 K, an inferred mass of 7+4 -3 MJ, and a luminosity of log(L/L) approx. -3.80 +/- 0.02. The best-estimated planet radius, is approx. equal to 1.65 +/- 0.06 RJ, is near the upper end of allowable planet radii for hot-start models given the host star's age and likely reflects challenges constructing accurate atmospheric models. Alternatively, these radii are comfortably consistent with hot-start model predictions if Beta Pic b is younger than is approx. equal to 7 Myr, consistent with a late formation well after its host star's birth approx. 12+8 -4 Myr ago.

  11. SPECT imaging using [{sup 123}I]{beta}-CIT and [{sup 123}I]IBF in extrapyramidal diseases

    Energy Technology Data Exchange (ETDEWEB)

    Sasaki, Takahiro; Amano, Takahiro; Hashimoto, Jun; Itoh, Yoshiaki; Muramatsu, Kazuhiro; Kubo, Atsushi; Fukuuchi, Yasuo [Keio Univ., Tokyo (Japan). School of Medicine

    2003-01-01

    Imaging of dopaminergic function is useful in the investigation of patients with Parkinson disease (iPD) and other extrapyramidal diseases. Using agents that bind to dopamine transporters ([{sup 123}I]{beta}-CIT) and receptors ([{sup 123}I]IBF SPECT), we investigated SPECT in 9 healthy volunteers and 24 patients for dopamine transporters as well as 15 patients for dopamine receptors. In {beta}-CIT SPECT studies, we examined 17 iPD patients (63.3{+-}9.9 y/o), 3 multiple system atrophy (MSA) patients (olivopontocerebellar atrophy (OPCA) type) (64.0{+-}8.0 y/o), 2 vascular parkinsonism (VP) patients (71.0{+-}0.0 y/o), 1 progressive supranuclear palsy (PSP) patient (69 y/o), 1 cortico-basal degeneration (CBD) patient (50 y/o) and nine healthy controls (39.1{+-}9.3 y/o). For IBF SPECT studies 11 iPD patients (60.6{+-}10.9 y/o), 3 MSA patients (2 OPCA type (50.5{+-}3.5 y/o) and 1 striatonigral degeneration (SND) type (65 y/o)) and 1 PSP patient (60 y/o) underwent SPECT scans after the injection of [{sup 123}I]IBF. The specific to nonspecific striatal ratio (St/Oc-1), ratio of putaminal uptake to caudatal uptake (Pu/Ca), and asymmetry indices (AI) were estimated. {beta}-CIT studies showed ST/Oc-1 as follows; iPD: 2.66{+-}1.09 (n=17), VP: 5.73 and 7.39, MSA: 1.84{+-}0.46 (n=3), PSP: 2.34, CBD: 2.16. In all extrapyramidal diseases except VP, St/Oc-1 ratios were significantly lower than those in normal volunteers (6.46{+-}1.08) (p<0.01). Also in early-phase iPD patients (Yahr I-II), St/Oc-1 (3.16{+-}1.49: n=4) was significantly lower than those in normal volunteers (p<0.01). In IBF studies, St/Oc-1 ratios were significantly higher in early-phase (Yahr I-II) iPD patients (1.82{+-}0.25: n=5) than those in late-phase (Yahr III-IV) iPD patients (1.38{+-}0.32: n=6) (p<0.05). The Pu/Ca ratios in iPD patients (1.12{+-}0.13) and MSA (OPCA type) patients (0.95{+-}0.05) were higher than that in MSA (SND type) patient (0.78) and were lower than that in PSP patient (1.55). In conclusion

  12. Combining image processing and modeling to generate traces of beta-strands from cryo-EM density images of beta-barrels.

    Science.gov (United States)

    Si, Dong; He, Jing

    2014-01-01

    Electron cryo-microscopy (Cryo-EM) technique produces 3-dimensional (3D) density images of proteins. When resolution of the images is not high enough to resolve the molecular details, it is challenging for image processing methods to enhance the molecular features. β-barrel is a particular structure feature that is formed by multiple β-strands in a barrel shape. There is no existing method to derive β-strands from the 3D image of a β-barrel at medium resolutions. We propose a new method, StrandRoller, to generate a small set of possible β-traces from the density images at medium resolutions of 5-10Å. StrandRoller has been tested using eleven β-barrel images simulated to 10Å resolution and one image isolated from the experimentally derived cryo-EM density image at 6.7Å resolution. StrandRoller was able to detect 81.84% of the β-strands with an overall 1.5Å 2-way distance between the detected and the observed β-traces, if the best of fifteen detections is considered. Our results suggest that it is possible to derive a small set of possible β-traces from the β-barrel cryo-EM image at medium resolutions even when no separation of the β-strands is visible in the images.

  13. Intellectual system for images restoration

    Science.gov (United States)

    Mardare, Igor

    2005-02-01

    Intelligence systems on basis of artificial neural networks and associative memory allow to solve effectively problems of recognition and restoration of images. However, within analytical technologies there are no dominating approaches of deciding of intellectual problems. Choice of the best technology depends on nature of problem, features of objects, volume of represented information about the object, number of classes of objects, etc. It is required to determine opportunities, preconditions and field of application of neural networks and associative memory for decision of problem of restoration of images and to use their supplementary benefits for further development of intelligence systems.

  14. Single-molecule imaging of {beta}-actin mRNAs in the cytoplasm of a living cell

    Energy Technology Data Exchange (ETDEWEB)

    Yamagishi, Mai; Ishihama, Yo [Laboratory of Bio-Analytical Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033 (Japan); Shirasaki, Yoshitaka [Laboratory of Genome Technology, Department of Human Genome Research, Kazusa DNA Research Institute, Kisarazu, Chiba 292-0818 (Japan); Kurama, Hideki [Major in Integrative Bioscience and Biomedical Engineering, Graduate School of Science and Engineering, Waseda University, Shinjuku-ku, Tokyo 169-8555 (Japan); Funatsu, Takashi, E-mail: funatsu@mail.ecc.u-tokyo.ac.jp [Laboratory of Bio-Analytical Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033 (Japan); Center for NanoBio Integration, The University of Tokyo, Bunkyo-ku, Tokyo 113-8656 (Japan)

    2009-04-15

    {beta}-Actin mRNA labeled with an MS2-EGFP fusion protein was expressed in chicken embryo fibroblasts and its localization and movement were analyzed by single-molecule imaging. Most {beta}-Actin mRNAs localized to the leading edge, while some others were observed in the perinuclear region. Singe-molecule tracking of individual mRNAs revealed that the majority of mRNAs were in unrestricted Brownian motion at the leading edge and in restricted Brownian motion in the perinuclear region. The macroscopic diffusion coefficient of mRNA (D{sub MACRO}) at the leading edge was 0.3 {mu}m{sup 2}/s. On the other hand, D{sub MACRO} in the perinuclear region was 0.02 {mu}m{sup 2}/s. The destruction of microfilaments with cytochalasin D, which is known to delocalize {beta}-actin mRNAs, led to an increase in D{sub MACRO} to 0.2 {mu}m{sup 2}/s in the perinuclear region. These results suggest that the microstructure, composed of microfilaments, serves as a barrier for the movement of {beta}-actin mRNA.

  15. The Groningen image processing system

    International Nuclear Information System (INIS)

    Allen, R.J.; Ekers, R.D.; Terlouw, J.P.

    1985-01-01

    This paper describes an interactive, integrated software and hardware computer system for the reduction and analysis of astronomical images. A short historical introduction is presented before some examples of the astonomical data currently handled by the system are shown. A description is given of the present hardware and software structure. The system is illustrated by describing its appearance to the user, to the applications programmer, and to the system manager. Some quantitative information on the size and cost of the system is given, and its good and bad features are discussed

  16. Determination of potassium in feldspars by beta counting using a GM multicounter system

    Energy Technology Data Exchange (ETDEWEB)

    Boetter-Jensen, L; Mejdahl, V

    1985-01-01

    A gas flow multicounter system developed at Risoe National laboratory for low-level beta counting applications was adopted for measuring potassium in feldspars extracted from archaeological and geological materials, in connection with TL dating work. A guard counter reduces the background by using an anticoincidence technique. Calibration was accomplished by measuring KCl and a feldspar standard. A potassium content of 1% yields a net beta count rate (background subtracted) of about 40 c.p.h.; the background is around 15 c.p.h. The precision in repeated measurements is better than 2% and the estimated accuracy is about 3%.

  17. Urinary albumin and beta 2-microglobulin excretion rates in patients with systemic lupus erythematosus

    DEFF Research Database (Denmark)

    Parving, H H; Sørensen, S F; Mogensen, C E

    1980-01-01

    The daily urinary albumin and beta 2-microglobulin excretion rates were measured with sensitive radioimmunoassays in 14 patients with systemic lupus erythematosus (SLE). The duration of SLE ranged from 0.5 to 18 years, mean 10 years. The mean age was 37 years. All patients except 5 received...... prednisone, 5-20 mg/day. None of the patients had proteinuria as judged by the "Albustix" test, and all had normal serum creatinine. The daily urinary albumin and beta 2-microglobulin excretion rates were nearly the same as those previously found by us in 27 adult control subjects with a mean age of 44 years...

  18. Musashi dynamic image processing system

    International Nuclear Information System (INIS)

    Murata, Yutaka; Mochiki, Koh-ichi; Taguchi, Akira

    1992-01-01

    In order to produce transmitted neutron dynamic images using neutron radiography, a real time system called Musashi dynamic image processing system (MDIPS) was developed to collect, process, display and record image data. The block diagram of the MDIPS is shown. The system consists of a highly sensitive, high resolution TV camera driven by a custom-made scanner, a TV camera deflection controller for optimal scanning, which adjusts to the luminous intensity and the moving speed of an object, a real-time corrector to perform the real time correction of dark current, shading distortion and field intensity fluctuation, a real time filter for increasing the image signal to noise ratio, a video recording unit and a pseudocolor monitor to realize recording in commercially available products and monitoring by means of the CRTs in standard TV scanning, respectively. The TV camera and the TV camera deflection controller utilized for producing still images can be applied to this case. The block diagram of the real-time corrector is shown. Its performance is explained. Linear filters and ranked order filters were developed. (K.I.)

  19. Urinary albumin and beta 2-microglobulin excretion rates in patients with systemic lupus erythematosus

    DEFF Research Database (Denmark)

    Parving, H H; Sørensen, S F; Mogensen, C E

    1980-01-01

    The daily urinary albumin and beta 2-microglobulin excretion rates were measured with sensitive radioimmunoassays in 14 patients with systemic lupus erythematosus (SLE). The duration of SLE ranged from 0.5 to 18 years, mean 10 years. The mean age was 37 years. All patients except 5 received...

  20. Low background gas flow beta counting system [Paper No.:M2

    International Nuclear Information System (INIS)

    Abani, M.C.; Anilkumar, S.; Bhende, D.R.; Krishnan, Narayani; Babu, D.A.R.

    1993-01-01

    It is difficult to count beta samples of low specific activity in conventional types of counting systems which have inherently high background. This is specially true in case of environmental samples. A gas flow type beta counter has been developed which have the twin advantage of high efficiency and low background. This system uses a gas flow type main counter and another gas flow type guard counter working on the same principle in anticoincidence mode. Both counters are operated in G.M. region. With this anticoincidence arrangement and lead shielding of 3 inch, the system has the background of the order of 1 cpm and efficiency of 40% for 40 K beta and 14% for 14 C beta. The electronics developed includes a quenching cum coincidence-anticoincidence unit, EHT and a counter timer. This paper describes in detail the development and operational experience with the system. A number of units are already operational at BARC and at Environmental Survey Laboratories set up by Department of Atomic Energy and at various other institutions. (author). 4 refs., 2 figs

  1. Determination of Potassium in Feldspars by Beta Counting Using a GM Multicounter System

    DEFF Research Database (Denmark)

    Bøtter-Jensen, Lars; Mejdahl, V.

    1985-01-01

    A gas flow multicounter system developed at Riso National Laboratory for low-level beta counting applications was adopted for measuring potassium in feldspars extracted from archaeological and geological materials, in connection with TL dating work. A guard counter reduces the background by using...

  2. Equilibrium and stability of high-beta plasma in a finite l=+-1 toroidal system

    International Nuclear Information System (INIS)

    Shiina, S.; Saito, K.; Todoroki, J.; Hamada, S.; Gesso, H.; Nogi, Y.; Osanai, Y.; Yoshimura, H.

    1983-01-01

    The equilibrium and stability are theoretically and experimentally investigated of high-beta plasma in the Modified Bumpy Torus, which is an asymmetric closed-line system with fairly large l=0 and l=+-1 field components. The finiteness of the l=+-1 component induces significant stabilizing effects due both to self formation of a magnetic well and to the conducting wall. (author)

  3. Scanning Terahertz Heterodyne Imaging Systems

    Science.gov (United States)

    Siegel, Peter; Dengler, Robert

    2007-01-01

    Scanning terahertz heterodyne imaging systems are now at an early stage of development. In a basic scanning terahertz heterodyne imaging system, (see Figure 1) two far-infrared lasers generate beams denoted the local-oscillator (LO) and signal that differ in frequency by an amount, denoted the intermediate frequency (IF), chosen to suit the application. The LO beam is sent directly to a mixer as one of two inputs. The signal beam is focused to a spot on or in the specimen. After transmission through or reflection from the specimen, the beams are focused to a spot on a terahertz mixer, which extracts the IF outputs. The specimen is mounted on a translation stage, by means of which the focal spot is scanned across the specimen to build up an image.

  4. 3D Backscatter Imaging System

    Science.gov (United States)

    Whitaker, Ross (Inventor); Turner, D. Clark (Inventor)

    2016-01-01

    Systems and methods for imaging an object using backscattered radiation are described. The imaging system comprises both a radiation source for irradiating an object that is rotationally movable about the object, and a detector for detecting backscattered radiation from the object that can be disposed on substantially the same side of the object as the source and which can be rotationally movable about the object. The detector can be separated into multiple detector segments with each segment having a single line of sight projection through the object and so detects radiation along that line of sight. Thus, each detector segment can isolate the desired component of the backscattered radiation. By moving independently of each other about the object, the source and detector can collect multiple images of the object at different angles of rotation and generate a three dimensional reconstruction of the object. Other embodiments are described.

  5. Image reconstruction of dynamic infrared single-pixel imaging system

    Science.gov (United States)

    Tong, Qi; Jiang, Yilin; Wang, Haiyan; Guo, Limin

    2018-03-01

    Single-pixel imaging technique has recently received much attention. Most of the current single-pixel imaging is aimed at relatively static targets or the imaging system is fixed, which is limited by the number of measurements received through the single detector. In this paper, we proposed a novel dynamic compressive imaging method to solve the imaging problem, where exists imaging system motion behavior, for the infrared (IR) rosette scanning system. The relationship between adjacent target images and scene is analyzed under different system movement scenarios. These relationships are used to build dynamic compressive imaging models. Simulation results demonstrate that the proposed method can improve the reconstruction quality of IR image and enhance the contrast between the target and the background in the presence of system movement.

  6. Imaging Systems in TLE Research

    DEFF Research Database (Denmark)

    Allin, Thomas Højgaard; Neubert, Torsten; Laursen, Steen

    2006-01-01

    documented using the right equipment in the right way. This chapter provides an introduction to the concepts of low light imagers, and how they can be successfully applied in TLE research. As examples, we describe the 2003 and 2004 Spritewatch systems, which integrate low-light cameras with a digital...

  7. Improvement and automatization of a proportional alpha-beta counting system - FAG

    International Nuclear Information System (INIS)

    German, U.; Levinson, S.; Pelled, O.; Shemesh, Y.; Assido, H.

    1997-01-01

    An alpha and beta counting system - FAG*, for planchette samples is operated at the Health Physics department's laboratory of the NRCN. The original operation mode of the system was based on manual tasks handled by the FHT1 100 electronics. An option for a basic computer keyboard operation was available too. A computer with an appropriate I/O card was connected to the system and a new operating program was developed which enables full automatic control of the various components. The program includes activity calculations and statistical checks as well as data management. A bar-code laser system for sample number reading was integrated into the Alpha-Beta automatic counting system. The sample identification by means of an attached bar-code label enables unmistakable and reliable attribution of results to the counted sample. authors)

  8. Design of microemulsion system suitable for the oral delivery of poorly aqueous soluble beta-carotene.

    Science.gov (United States)

    Peng, Cheng; Svirskis, Darren; Lee, Sung Je; Oey, Indrawati; Kwak, Hae-Soo; Chen, Guanyu; Bunt, Craig; Wen, Jingyuan

    2017-02-14

    Beta-carotene is a potent antioxidant for maintaining human health. However, its oral absorption is low due to poor aqueous solubility of less than 1 μg/ml. A microemulsion delivery system was designed to solubilize beta-carotene toward enhancing its oral bioavailability. From seven pseudoternary diagrams constructed, three systems were selected with large microemulsion areas suitable for oral administration and dilution in the predominately aqueous gastrointestinal fluids. Conductivity and rheology characterization were conducted along four dilution lines within the selected systems. Three pseudoternary-phase diagrams were selected with large microemulsion regions, >60% of the total phase diagram area, which provide microemulsions with higher drug-loading capacity. A phenomenon was observed by which both propylene glycol and Capmul MCM EP stabilize the microstructure of the microemulsions has been proposed based on the characterization studies. An optimal bicontinuous microemulsion formulation was selected comprising 12% orange oil, 24% Capmul MCM, 18% Tween 20, 6% Labrasol, 20% propylene glycol and 20% water, with a high beta-carotene loading capacity of 140.8 μg/ml and droplet size of 117.4 nm. In conclusion, the developed novel microemulsion formulation allows solubilizing beta-carotene and is a promising basis for further development as a functional beverage.

  9. A Method Validation for Determination of Gross Alpha and Gross Beta in Water Sample Using Low Background Gross Alpha/ Beta Counting System

    International Nuclear Information System (INIS)

    Zal Uyun Wan Mahmood; Norfaizal Mohamed; Nita Salina Abu Bakar

    2016-01-01

    Method validation (MV) for the measurement of gross alpha and gross beta activity in water (drinking, mineral and environmental) samples using Low Background Gross Alpha/ Beta Counting System was performed to characterize precision, accuracy and reliable results. The main objective of this assignment is to ensure that both the instrument and method always good performed and resulting accuracy and reliable results. Generally, almost the results of estimated RSD, z-score and U_s_c_o_r_e were reliable which are recorded as ≤30 %, less than 2 and less than 1.5, respectively. Minimum Detected Activity (MDA) was estimated based on the counting time of 100 minutes and present background counting value of gross alpha (0.01 - 0.35 cpm) and gross beta (0.50 - 2.18 cpm). Estimated Detection Limit (DL) was 0.1 Bq/ L for gross alpha and 0.2 Bq/ L for gross beta and expended uncertainty was relatively small of 9.77 % for gross alpha and 10.57 % for gross beta. Align with that, background counting for gross alpha and gross beta was ranged of 0.01 - 0.35 cpm and 0.50 - 2.18 cpm, respectively. While, sample volume was set at minimum of 500 mL and maximum of 2000 mL. These proven the accuracy and precision result that are generated from developed method/ technique is satisfactory and method is recommended to be used. Therefore, it can be concluded that the MV found no doubtful on the ability of the developed method. The test result showed the method is suitable for all types of water samples which are contained several radionuclides and elements as well as any impurities that interfere the measurement analysis of gross alpha and gross beta. (author)

  10. Islet-selectivity of G-protein coupled receptor ligands evaluated for PET imaging of pancreatic {beta}-cell mass

    Energy Technology Data Exchange (ETDEWEB)

    Cline, Gary W., E-mail: gary.cline@yale.edu [Yale University School of Medicine (United States); Zhao, Xiaojian [Yale University School of Medicine (United States); Jakowski, Amy B.; Soeller, Walter C.; Treadway, Judith L. [Pfizer Global Research and Development, Pfizer Inc., Groton CT (United States)

    2011-09-02

    Highlights: {yields} We screened G-protein coupled receptors for imaging pancreatic. {yields} Database mining and immunohistochemistry identified GPCRs enriched in {beta}-cells. {yields} In vitro and in vivo assays were used to determine exocrine vs endocrine specificity. {yields} GPCR candidates for imaging of {beta}-cell mass are Prokineticin-1R, mGluR5, and GLP-1R. -- Abstract: A critical unmet need exists for methods to quantitatively measure endogenous pancreatic {beta}-cell mass (BCM) for the clinical evaluation of therapies to prevent or reverse loss of BCM and diabetes progression. Our objective was to identify G-protein coupled receptors (GPCRs) that are expressed with a high degree of specificity to islet {beta}-cells for receptor-targeted imaging of BCM. GPCRs enriched in pancreatic islets relative to pancreas acinar and hepatic tissue were identified using a database screen. Islet-specific expression was confirmed by human pancreas immunohistochemistry (IHC). In vitro selectivity assessment was determined from the binding and uptake of radiolabeled ligands to the rat insulinoma INS-1 832/13 cell line and isolated rat islets relative to the exocrine pancreas cell-type, PANC-1. Tail-vein injections of radioligands into rats were used to determine favorable image criteria of in vivo biodistribution to the pancreas relative to other internal organs (i.e., liver, spleen, stomach, and lungs). Database and IHC screening identified four candidate receptors for further in vitro and in vivo evaluation for PET imaging of BCM: prokineticin-1 receptor (PK-1R), metabotropic glutamate receptor type-5 (mGluR5), neuropeptide Y-2 receptor (NPY-2R), and glucagon-like peptide 1 receptor (GLP-1R). In vitro specificity ratios gave the following receptor rank order: PK-1R > GLP-1R > NPY-2R > mGluR5. The biodistribution rank order of selectivity to the pancreas was found to be PK-1R > VMAT2 {approx} GLP-1R > mGluR5. Favorable islet selectivity and biodistribution

  11. Analysis of the surface technology of silicon detectors for imaging of low-energy beta tracers in biological material

    CERN Document Server

    Tykva, R

    2000-01-01

    Using silicon surface barrier detectors, the counting sensitivity of low-energy beta tracers is considerably influenced by surface technology applied in detector manufacturing. Original diagnostic procedure, using a mixture of uranium fission products, is described to trace the behaviors of different admixtures as in the etching bath as in the water used during development of the detector surface. In combination with some other described analyses, the detectors produced with the developed surface control are used in a PC - controlled scanning equipment reaching at room temperature an FWHM of 3.4 keV for sup 2 sup 4 sup 1 Am. Such detectors make it possible to image distribution, of e.g., sup 3 H, sup 1 sup 2 sup 5 I, sup 3 H+ sup 1 sup 4 C and other beta tracer combinations applied in life and environmental sciences.

  12. Imaging systems for medical diagnostics

    International Nuclear Information System (INIS)

    Krestel, E.

    1990-01-01

    This book provides physicians and clinical physicists with detailed information on today's imaging modalities and assists them in selecting the optimal system for each clinical application. Physicists, engineers and computer specialists engaged in research and development and sales departments will also find this book to be of considerable use. It may also be employed at universities, training centers and in technical seminars. The physiological and physical fundamentals are explained in part 1. The technical solutions contained in part 2 illustrate the numerous possibilities available in X-ray diagnostics, computed tomography, nuclear medical diagnostics, magnetic resonance imaging, sonography and biomagnetic diagnostics. (orig.)

  13. From Demonstration System to Prototype: ShakeAlert Beta Users Provide Feedback to Improve Alert Delivery

    Science.gov (United States)

    Strauss, J. A.; Vinci, M.; Steele, W. P.; Allen, R. M.; Hellweg, M.

    2013-12-01

    Earthquake Early Warning (EEW) is a system that can provide a few to tens of seconds to minutes of warning prior to ground shaking at a given location. The goal and purpose of such a system is to reduce the damage, costs, and casualties resulting from an earthquake. A prototype earthquake early warning system (ShakeAlert) is in development by the UC Berkeley Seismological Laboratory, Caltech, ETH Zurich, University of Washington, and the USGS. Events are published to the UserDisplay--ShakeAlert's Java based graphical interface, which is being tested by a small group of beta users throughout California. The beta users receive earthquake alerts in real-time and are providing feedback on their experiences. For early warning alerts to be useful, people, companies, and institutions must know beforehand what actions they will perform when they receive the information. Beta user interactions allow the ShakeAlert team to discern: which alert delivery options are most effective, what changes would make the UserDisplay more useful in a pre-disaster situation, and most importantly, what actions users plan to take for various scenarios. We also collect feedback detailing costs of implementing actions and challenges within the beta user organizations, as well as anticipated benefits and savings. Thus, creating a blueprint for a fully operational system that will meet the needs of the public. New California users as well as the first group of Pacific Northwest users are slated to join the ShakeAlert beta test group in the fall of 2013.

  14. Imaging systems in nuclear medicine and image evaluation

    International Nuclear Information System (INIS)

    Beck, R.; Charleston, D.; Metz, C.

    1980-01-01

    This project deals with imaging systems in nuclear medicine and image evaluation and is presented as four subprojects. The goal of the first subproject is to improve diagnositc image quality by development of a general computer code for optimizing collimator design. The second subproject deals with a secondary emission and fluorescence technique for thyroid scanning while the third subproject emphasizes the need for more sophisticated image processing systems such as coherent optical spatial filtering systems and digital image processing. The fourth subproject presents a new approach for processing image data by taking into account the energy of each detected gamma-ray photon

  15. Multispectral Panoramic Imaging System, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — International Electronic Machines Corporation, a leader in the design of precision imaging systems, will develop an innovative multispectral, panoramic imaging...

  16. Molecular imaging of alpha v beta3 integrin expression in atherosclerotic plaques with a mimetic of RGD peptide grafted to Gd-DTPA.

    Science.gov (United States)

    Burtea, Carmen; Laurent, Sophie; Murariu, Oltea; Rattat, Dirk; Toubeau, Gérard; Verbruggen, Alfons; Vansthertem, David; Vander Elst, Luce; Muller, Robert N

    2008-04-01

    The integrin alpha v beta3 is highly expressed in atherosclerotic plaques by medial and intimal smooth muscle cells and by endothelial cells of angiogenic microvessels. In this study, we have assessed non-invasive molecular magnetic resonance imaging (MRI) of plaque-associated alpha v beta3 integrin expression on transgenic ApoE-/- mice with a low molecular weight peptidomimetic of Arg-Gly-Asp (mimRGD) grafted to gadolinium diethylenetriaminepentaacetate (Gd-DTPA-g-mimRGD). The analogous compound Eu-DTPA-g-mimRGD was employed for an in vivo competition experiment and to confirm the molecular targeting. The specific interaction of mimRGD conjugated to Gd-DTPA or to 99mTc-DTPA with alpha v beta3 integrin was furthermore confirmed on Jurkat T lymphocytes. The mimRGD was synthesized and conjugated to DTPA. DTPA-g-mimRGD was complexed with GdCl3.6H2O, EuCl3.6H2O, or with [99mTc(CO)3(H2O)3]+. MRI evaluation was performed on a 4.7 T Bruker imaging system. Blood pharmacokinetics of Gd-DTPA-g-mimRGD were assessed in Wistar rats and in c57bl/6j mice. The presence of angiogenic blood vessels and the expression of alpha v beta3 integrin were confirmed in aorta specimens by immunohistochemistry. Gd-DTPA-g-mimRGD produced a strong enhancement of the external structures of the aortic wall and of the more profound layers (possibly tunica media and intima). The aortic lumen seemed to be restrained and distorted. Pre-injection of Eu-DTPA-g-mimRGD diminished the Gd-DTPA-g-mimRGD binding to atherosclerotic plaque and confirmed the specific molecular targeting. A slower blood clearance was observed for Gd-DTPA-g-mimRGD, as indicated by a prolonged elimination half-life and a diminished total clearance. The new compound is potentially useful for the diagnosis of vulnerable atherosclerotic plaques and of other pathologies characterized by alpha v beta3 integrin expression, such as cancer and inflammation. The delayed blood clearance, the significant enhancement of the signal

  17. Antagonizing the alpha(4)beta(1) Integrin, but Not alpha(4)beta(7), Inhibits Leukocytic Infiltration of the Central Nervous System in Rhesus Monkey Experimental Autoimmune Encephalomyelitis

    NARCIS (Netherlands)

    Haanstra, Krista G.; Hofman, Sam O.; Estevao, Dave M. Lopes; Blezer, Erwin L. A.; Bauer, Jan; Yang, Li-Li; Wyant, Tim; Csizmadia, Vilmos; 't Hart, Bert A.; Fedyk, Eric R.

    2013-01-01

    The immune system is characterized by the preferential migration of lymphocytes through specific tissues (i.e., tissue tropism). Tissue tropism is mediated, in part, by the alpha(4) integrins expressed by T lymphocytes. The alpha(4)beta(1) integrin mediates migration of memory T lymphocytes into the

  18. New miniaturized alpha/beta spectrometric system for the surface contamination monitoring and radon personal dosimeter

    International Nuclear Information System (INIS)

    Streil, T.; Oeser, V.; Holfeld, G.

    1998-01-01

    The heart of the new miniaturized alpha/beta spectroscopic system is a Smart Card MCA having a 12 bit resolution and a 32 bit memory for each channel with the size of a cheque card. The system consists of a single or up to 12 alpha spectrometers in a battery powered casing with connectors for direct detector/amplifier module plugging. Surface contamination in the order of 1 Bq/cm 2 of 239 Pu can be measured. (M.D.)

  19. Prognostic significance of myocardial imaging with iodine-123 beta-methyl-p-iodophenyl-pentadecanoic acid in patients with angina pectoris

    International Nuclear Information System (INIS)

    Hatano, Tsuguhisa; Chikamori, Taishiro; Kamada, Tatsuya; Morishima, Takayuki; Hida, Satoshi; Yanagisawa, Hidefumi; Iino, Hitoshi; Yamashina, Akira

    2001-01-01

    To assess the clinical significance of iodine-123 beta-methyl-p-iodophenyl-pentadecanoic acid (BMIPP) single photon emission computed tomography (SPECT), the predictive value of BMIPP imaging in patients with angina pectoris was evaluated. One hundred seventy-four patients who underwent BMIPP imaging in our institution were aged 61.8±11 years. One hundred thirty-five patients had stable angina and 39 had unstable angina at the time of examination. Patients with previous myocardial infarction or myocardial disorders were excluded. Early and delayed images were acquired in BMIPP SPECT, and the images were analyzed visually. Cardiac events were classified into hard and soft events: the former consisted of cardiac death and nonfatal myocardial infarction, and the latter included coronary revascularization and heart failure. The findings of BMIPP imaging were normal in 82 patients and abnormal in 92. During follow-up of 15.5±9.5 months, hard events were observed in 4 patients and soft events in 53. In patients with normal BMIPP imaging, soft events were observed in nine patients, but no hard event was encountered. Furthermore, in patients with both normal BMIPP and stress thallium imagings, no cardiac event was observed during 2 years. In contrast, 4 hard events and 44 soft events occurred in patients with abnormal BMIPP imaging. Patients with abnormal BMIPP imaging had a higher incidence of soft events than those with normal BMIPP imaging, regardless of the type of angina (16/62 vs 3/73, p<0.0005 for stable angina; 28/30 vs 6/9, p<0.0001 for unstable angina). The finding of BMIPP imaging correlates well with the mid-term prognosis of patients with angina pectoris. Since BMIPP SPECT is performed without stress to the patient, this imaging modality is important in evaluating patients with stable or unstable angina. (author)

  20. A bar-code reader for an alpha-beta automatic counting system - FAG

    International Nuclear Information System (INIS)

    Levinson, S.; Shemesh, Y.; Ankry, N.; Assido, H.; German, U.; Peled, O.

    1996-01-01

    A bar-code laser system for sample number reading was integrated into the FAG Alpha-Beta automatic counting system. The sample identification by means of an attached bar-code label enables unmistakable and reliable attribution of results to the counted sample. Installation of the bar-code reader system required several modifications: Mechanical changes in the automatic sample changer, design and production of new sample holders, modification of the sample planchettes, changes in the electronic system, update of the operating software of the system (authors)

  1. A bar-code reader for an alpha-beta automatic counting system - FAG

    Energy Technology Data Exchange (ETDEWEB)

    Levinson, S; Shemesh, Y; Ankry, N; Assido, H; German, U; Peled, O [Israel Atomic Energy Commission, Beersheba (Israel). Nuclear Research Center-Negev

    1996-12-01

    A bar-code laser system for sample number reading was integrated into the FAG Alpha-Beta automatic counting system. The sample identification by means of an attached bar-code label enables unmistakable and reliable attribution of results to the counted sample. Installation of the bar-code reader system required several modifications: Mechanical changes in the automatic sample changer, design and production of new sample holders, modification of the sample planchettes, changes in the electronic system, update of the operating software of the system (authors).

  2. Analysis of the transforming growth factor-beta1 pathway and extracellular matrix formation as a hybrid system

    NARCIS (Netherlands)

    Musters, M.W.J.M.; Riel, van N.A.W.

    2004-01-01

    It is generally accepted that aging of the vascular system plays an important role in cardiovascular disease (CVD). Recent experimental findings have indicated the involvement of the cytokine transforming growth factor-/spl beta//sub 1/ (TGF-/spl beta//sub 1/) in these vascular aging processes. This

  3. Extrasynaptic location of alpha-2 and noninnervated beta-2 adrenoceptors in the vascular system of the pithed normotensive rat

    NARCIS (Netherlands)

    Wilffert, B.; Timmermans, P.B.M.W.M.; Van Zwieten, P.A.

    1982-01-01

    The receptors involved in the pressor and tachycardic effects of catecholamines applied systemically or released from sympathetic nerve endings were compared. Intravenously administered (-)-epinephrine activated alpha-1, alpha-2, beta-1 and beta-2 adrenoceptors as demonstrated in pithed rats, using

  4. Imaging systems and materials characterization

    International Nuclear Information System (INIS)

    Murr, L.E.

    2009-01-01

    This paper provides a broad background for the historical development and modern applications of light optical metallography, scanning and transmission electron microscopy, field-ion microscopy and several forms of scanning probe microscopes. Numerous case examples illustrating especially synergistic applications of these imaging systems are provided to demonstrate materials characterization especially in the context of structure-property-performance issues which define materials science and engineering

  5. GEOREFERENCED IMAGE SYSTEM WITH DRONES

    Directory of Open Access Journals (Sweden)

    Héctor A. Pérez-Sánchez

    2017-07-01

    Full Text Available This paper has as general purpose develop and implementation of a system that allows the generation of flight routes for a drone, the acquisition of geographic location information (GPS during the flight and taking photographs of points of interest for creating georeferenced images, same that will be used to generate KML files (Keyhole Markup Language for the representation of geographical data in three dimensions to be displayed on the Google Earth tool.

  6. Adrenal glands in beta-thalassemia major: magnetic resonance (MR) imaging features and correlation with iron stores

    International Nuclear Information System (INIS)

    Drakonaki, Eleni; Papakonstantinou, Olympia; Maris, Thomas; Gourtsoyiannis, Nicholas; Vasiliadou, Artemis; Papadakis, Alex

    2005-01-01

    This study aimed at describing the magnetic resonance (MR) imaging features of the adrenal glands in beta-thalassemic patients and at investigating the relation between adrenal and hepatic siderosis. Adrenal signal intensity (SI) was retrospectively assessed on abdominal MR studies of 35 patients with beta-thalassemia major undergoing quantification of hepatic siderosis and 12 healthy controls, using T1- (120/4/90), intermediate - (120/4/20), and T2*- (120/15/20) weighted GRE sequences. Adrenal SI was graded as grade 0 (normal SI on all sequences), grade 1 (hypointensity on T2* alone), or grade 2 (hypointensity on at least T2*). Adrenal size was measured in the thalassemic patients and compared with normative data. Liver-to-muscle (L/M) SI ratios, expressing hepatic siderosis, were estimated on each sequence. Serum ferritin levels were recorded. Adrenal hypointensity (grades 1 and 2) was noted in 24/35 (68.6%) patients. L/M ratios correlated significantly with adrenal SI in all sequences. Patients with grade 1 and grade 2 adrenal SI had significantly decreased L/M ratios compared with grade 0. Serum ferritin correlated significantly with L/M values but not with adrenal SI. Adrenal size was within normal limits. Diffuse hypointensity in normal-sized adrenals is a common MR finding in beta-thalassemic patients and correlates with the degree of hepatic siderosis. (orig.)

  7. Adrenal glands in beta-thalassemia major: magnetic resonance (MR) imaging features and correlation with iron stores

    Energy Technology Data Exchange (ETDEWEB)

    Drakonaki, Eleni; Papakonstantinou, Olympia; Maris, Thomas; Gourtsoyiannis, Nicholas [University Hospital of Heraklion, Department of Radiology, Heraklion (Greece); Vasiliadou, Artemis [Aghios Georgios Hospital of Chania, Thalassemia Unit, Chania (Greece); Papadakis, Alex [Venizelion Hospital of Heraklion, Thalassemia Unit, Heraklion (Greece)

    2005-12-01

    This study aimed at describing the magnetic resonance (MR) imaging features of the adrenal glands in beta-thalassemic patients and at investigating the relation between adrenal and hepatic siderosis. Adrenal signal intensity (SI) was retrospectively assessed on abdominal MR studies of 35 patients with beta-thalassemia major undergoing quantification of hepatic siderosis and 12 healthy controls, using T1- (120/4/90), intermediate - (120/4/20), and T2*- (120/15/20) weighted GRE sequences. Adrenal SI was graded as grade 0 (normal SI on all sequences), grade 1 (hypointensity on T2* alone), or grade 2 (hypointensity on at least T2*). Adrenal size was measured in the thalassemic patients and compared with normative data. Liver-to-muscle (L/M) SI ratios, expressing hepatic siderosis, were estimated on each sequence. Serum ferritin levels were recorded. Adrenal hypointensity (grades 1 and 2) was noted in 24/35 (68.6%) patients. L/M ratios correlated significantly with adrenal SI in all sequences. Patients with grade 1 and grade 2 adrenal SI had significantly decreased L/M ratios compared with grade 0. Serum ferritin correlated significantly with L/M values but not with adrenal SI. Adrenal size was within normal limits. Diffuse hypointensity in normal-sized adrenals is a common MR finding in beta-thalassemic patients and correlates with the degree of hepatic siderosis. (orig.)

  8. Accounting for beta-particle energy loss to cortical bone via paired-image radiation transport (PIRT)

    International Nuclear Information System (INIS)

    Shah, Amish P.; Rajon, Didier A.; Patton, Phillip W.; Jokisch, Derek W.; Bolch, Wesley E.

    2005-01-01

    Current methods of skeletal dose assessment in both medical physics (radionuclide therapy) and health physics (dose reconstruction and risk assessment) rely heavily on a single set of bone and marrow cavity chord-length distributions in which particle energy deposition is tracked within an infinite extent of trabecular spongiosa, with no allowance for particle escape to cortical bone. In the present study, we introduce a paired-image radiation transport (PIRT) model which provides a more realistic three-dimensional (3D) geometry for particle transport in the skeletal site at both microscopic and macroscopic levels of its histology. Ex vivo CT scans were acquired of the pelvis, cranial cap, and individual ribs excised from a 66-year male cadaver (BMI of 22.7 kg m -2 ). For the three skeletal sites, regions of trabecular spongiosa and cortical bone were identified and segmented. Physical sections of interior spongiosa were taken and subjected to microCT imaging. Voxels within the resulting microCT images were then segmented and labeled as regions of bone trabeculae, endosteum, active marrow, and inactive marrow through application of image processing algorithms. The PIRT methodology was then implemented within the EGSNRC radiation transport code whereby electrons of various initial energies are simultaneously tracked within both the ex vivo CT macroimage and the CT microimage of the skeletal site. At initial electron energies greater than 50-200 keV, a divergence in absorbed fractions to active marrow are noted between PIRT model simulations and those estimated under existing techniques of infinite spongiosa transport. Calculations of radionuclide S values under both methodologies imply that current chord-based models may overestimate the absorbed dose to active bone marrow in these skeletal sites by 0% to 27% for low-energy beta emitters ( 33 P, 169 Er, and 177 Lu), by ∼4% to 49% for intermediate-energy beta emitters ( 153 Sm, 186 Re, and 89 Sr), and by ∼14% to

  9. Beta cell imaging - a key tool in optimized diabetes prevention and treatment

    NARCIS (Netherlands)

    Gotthardt, M.; Eizirik, D.L.; Cnop, M.; Brom, M.

    2014-01-01

    The prevalence of diabetes is 382 million worldwide, and is expected to rise to 592 million in 2035 (http://www.idf.org/diabetesatlas); 2.5-15\\% of national annual healthcare budgets are related to diabetes care, potentially increasing to 40\\% in high-prevalence countries. Beta cell dysfunction and

  10. Imaging of beta-Cell Mass and Insulitis in Insulin-Dependent (Type 1) Diabetes Mellitus

    NARCIS (Netherlands)

    Di Gialleonardo, Valentina; de Vries, Erik F. J.; Di Girolamo, Marco; Quintero, Ana M.; Dierckx, Rudi A. J. O.; Signore, Alberto

    2012-01-01

    Insulin-dependent (type 1) diabetes mellitus is a metabolic disease with a complex multifactorial etiology and a poorly understood pathogenesis. Genetic and environmental factors cause an autoimmune reaction against pancreatic beta-cells, called insulitis, confirmed in pancreatic samples obtained at

  11. Image and information management system

    Science.gov (United States)

    Robertson, Tina L. (Inventor); Raney, Michael C. (Inventor); Dougherty, Dennis M. (Inventor); Kent, Peter C. (Inventor); Brucker, Russell X. (Inventor); Lampert, Daryl A. (Inventor)

    2009-01-01

    A system and methods through which pictorial views of an object's configuration, arranged in a hierarchical fashion, are navigated by a person to establish a visual context within the configuration. The visual context is automatically translated by the system into a set of search parameters driving retrieval of structured data and content (images, documents, multimedia, etc.) associated with the specific context. The system places ''hot spots'', or actionable regions, on various portions of the pictorials representing the object. When a user interacts with an actionable region, a more detailed pictorial from the hierarchy is presented representing that portion of the object, along with real-time feedback in the form of a popup pane containing information about that region, and counts-by-type reflecting the number of items that are available within the system associated with the specific context and search filters established at that point in time.

  12. Monte Carlo simulation of the spectral response of beta-particle emitters in LSC systems

    International Nuclear Information System (INIS)

    Ortiz, F.; Los Arcos, J.M.; Grau, A.; Rodriguez, L.

    1992-01-01

    This paper presents a new method to evaluate the counting efficiency and the effective spectra at the output of any dynodic stage, for any pure beta-particle emitter, measured in a liquid scintillation counting system with two photomultipliers working in sum-coincidence mode. The process is carried out by a Monte Carlo simulation procedure that gives the electron distribution, and consequently the counting efficiency, at any dynode, in response to the beta particles emitted, as a function of the figure of merit of the system and the dynodic gains. The spectral outputs for 3 H and 14 C have been computed and compared with experimental data obtained with two sets of quenched radioactive standards of these nuclides. (orig.)

  13. Gd-EDDA/HYNIC-RGD as an MR molecular probe imaging integrin {alpha}{nu}{beta}3 receptor-expressed tumor-MR molecular imaging of angiogenesis

    Energy Technology Data Exchange (ETDEWEB)

    Huo Tianlong [Peking University People' s Hospital, Radiology Department, 11 Xizhimen South Street, Xicheng District, Beijing 100044 (China)], E-mail: huotianlong@bjmu.edu.cn; Du Xiangke [Peking University People' s Hospital, Radiology Department, 11 Xizhimen South Street, Xicheng District, Beijing 100044 (China)], E-mail: duxk@263.net; Zhang Sen [Peking University People' s Hospital, Radiology Department, 11 Xizhimen South Street, Xicheng District, Beijing 100044 (China)], E-mail: skagerrak_s@yahoo.com.cn; Liu Xia [Peking University People' s Hospital, Radiology Department, 11 Xizhimen South Street, Xicheng District, Beijing 100044 (China)], E-mail: iamliuxia@126.com; Li Xubing [Peking University People' s Hospital, Radiology Department, 11 Xizhimen South Street, Xicheng District, Beijing 100044 (China)], E-mail: lixb@bjmu.edu.cn

    2010-02-15

    Rationale and objective: The aim of this study is to develop a novel MR probe containing arginine-glycine-aspartic acid (RGD) motif for imaging integrin {alpha}{nu}{beta}3 receptor-expressed tumor. Materials and methods: Commercially available HYNIC-RGD conjugated with co-ligand EDDA was labeled with Gd{sup 3+}, and the mixture was isolated and purified by solid phase extract (SPE) to get the entire probe Gd-EDDA/HYNIC-RGD. Human hepatocellular carcinoma (HHCC) cell line BEL-7402 was cultured and the cells harvested and suspended in serum-free Dulbecco's modified Eagle medium (DMEM) were subcutaneously inoculated into athymic nude mice for tumor growth. In vitro cell binding assay to integrin {alpha}{nu}{beta}3 receptor and cell viability experiments were conducted. The in vivo imaging of the three arms of xenografts were performed by MR scan with a dedicated animal coil at time points of 0, 30, 60, 90 min and 24-h post-intravenous injection (p.i.). Three arms of nude mice then were sacrificed for histological examination to confirm the imaging results. Results: Gd-EDDA/HYNIC-RGD was successfully isolated by SPE and validity was verified on signal enhancement through in vitro and in vivo experiments. The nude mice model bearing HHCC was well established. There was approx. 30% signal enhancement on T1WI FSE images at 90 min post-intravenous injection of the Gd-EDDA/HYNIC-RGD compared with baseline, and the signal to time curve is straightforward over time in the span of 0-90 min p.i., while the control arms do not show this tendency. Conclusion: Gd-EDDA/HYNIC-RGD has the potential to serve as an MR probe detecting integrin {alpha}{nu}{beta}3 receptor-expressed tumor.

  14. X-ray imaging system

    International Nuclear Information System (INIS)

    Houston, J.M.

    1980-01-01

    A novel, high-speed apparatus for use in X-ray computerised tomography is described in detail. It consists of a semi-circular array of X-ray sources, collimators and an ion chamber array for detection of the X-rays. The X-ray sources may be pulsed in salvos such that the corresponding detectors in the array are only illuminated by one source. The use of computer controlled salvos speeds up the image processing by at least a factor of two. The ion chamber array is designed to have a constant detection efficiency for varying angles of X-ray incidence. A detailed description of the detector construction and suggested gaseous fillings are given. It is claimed that the present tomographic system allows fast and accurate imaging of internal body organs and is insensitive to the blurring effects which motion of these organs tends to produce. (UK)

  15. Whole body imaging system mechanism

    International Nuclear Information System (INIS)

    Carman, R.W.; Doherty, E.J.

    1980-01-01

    A radioisotope scanning apparatus for use in nuclear medicine is described in detail. The apparatus enables the quantification and spatial location of the radioactivity in a body section of a patient to be determined with high sensitivity. It consists of an array of highly focussed collimators arranged such that adjacent collimators move in the same circumferential but opposite radial directions. The explicit movements of the gantry are described in detail and may be controlled by a general purpose computer. The use of highly focussed collimators allows both a reasonable solid angle of acceptance and also high target to background images; additionally, dual radionuclide pharmaceutical studies can be performed simultaneously. It is claimed that the high sensitivity of the system permits the early diagnosis of pathological changes and the images obtained show accurately the location and shape of physiological abnormalities. (U.K.)

  16. Monte Carlo simulation of {beta}-{gamma} coincidence system using plastic scintillators in 4{pi} geometry

    Energy Technology Data Exchange (ETDEWEB)

    Dias, M.S. [Instituto de Pesquisas Energeticas e Nucleares: IPEN-CNEN/SP, Av. Prof. Lineu Prestes 2242, 05508-000 Sao Paulo, SP (Brazil)], E-mail: msdias@ipen.br; Piuvezam-Filho, H. [Instituto de Pesquisas Energeticas e Nucleares: IPEN-CNEN/SP, Av. Prof. Lineu Prestes 2242, 05508-000 Sao Paulo, SP (Brazil); Baccarelli, A.M. [Departamento de Fisica-PUC/SP-Rua Marques de Paranagua 111, 01303-050 Sao Paulo, SP (Brazil); Takeda, M.N. [Universidade Santo Amaro, UNISA-Rua Prof. Eneas da Siqueira Neto 340, 04829-300 Sao Paulo, SP (Brazil); Koskinas, M.F. [Instituto de Pesquisas Energeticas e Nucleares: IPEN-CNEN/SP, Av. Prof. Lineu Prestes 2242, 05508-000 Sao Paulo, SP (Brazil)

    2007-09-21

    A modified version of a Monte Carlo code called Esquema, developed at the Nuclear Metrology Laboratory in IPEN, Sao Paulo, Brazil, has been applied for simulating a 4{pi}{beta}(PS)-{gamma} coincidence system designed for primary radionuclide standardisation. This system consists of a plastic scintillator in 4{pi} geometry, for alpha or electron detection, coupled to a NaI(Tl) counter for gamma-ray detection. The response curves for monoenergetic electrons and photons have been calculated previously by Penelope code and applied as input data to code Esquema. The latter code simulates all the disintegration processes, from the precursor nucleus to the ground state of the daughter radionuclide. As a result, the curve between the observed disintegration rate as a function of the beta efficiency parameter can be simulated. A least-squares fit between the experimental activity values and the Monte Carlo calculation provided the actual radioactive source activity, without need of conventional extrapolation procedures. Application of this methodology to {sup 60}Co and {sup 133}Ba radioactive sources is presented and showed results in good agreement with a conventional proportional counter 4{pi}{beta}(PC)-{gamma} coincidence system.

  17. Mass outflow in the nearby proto-planetary system, Beta Pictoris

    International Nuclear Information System (INIS)

    Bruhweiler, F.C.; Grady, C.A.; Kondo, Yoji

    1991-01-01

    Previous spectral studies of circumstallar dust around the nearby, candidate proto-planetary system, Beta Pictoris, has detected only infalling gas. The lack of detectable mass outflow has been critical in the interpretation of the origin of the circumstellar gas and in our understanding of the evolutionary status of the Beta Pictoris system. IUE high-dispersion spectra are presented which show, in addition to infall, the presence of mass outflow, with a maximum observed outflow velocity of -60 km/s, and a corresponding instantaneous outflow rate of 1.1 x 10 to the -14th solar mass/yr, or 1.1 x 10 to the -11th Jupiter mass/yr. This mass outflow rate and terminal velocity are comparable to the magnitudes of mass infall rates and terminal velocities observed from late 1986 through early 1988. The implications of these observations on our understanding of the mechanisms producing infall from the surrounding circumstellar disk are discussed, as are the implications for our understanding of the evolutionary status of the Beta Pic system. 23 refs

  18. Design of low noise imaging system

    Science.gov (United States)

    Hu, Bo; Chen, Xiaolai

    2017-10-01

    In order to meet the needs of engineering applications for low noise imaging system under the mode of global shutter, a complete imaging system is designed based on the SCMOS (Scientific CMOS) image sensor CIS2521F. The paper introduces hardware circuit and software system design. Based on the analysis of key indexes and technologies about the imaging system, the paper makes chips selection and decides SCMOS + FPGA+ DDRII+ Camera Link as processing architecture. Then it introduces the entire system workflow and power supply and distribution unit design. As for the software system, which consists of the SCMOS control module, image acquisition module, data cache control module and transmission control module, the paper designs in Verilog language and drives it to work properly based on Xilinx FPGA. The imaging experimental results show that the imaging system exhibits a 2560*2160 pixel resolution, has a maximum frame frequency of 50 fps. The imaging quality of the system satisfies the requirement of the index.

  19. Image BOSS: a biomedical object storage system

    Science.gov (United States)

    Stacy, Mahlon C.; Augustine, Kurt E.; Robb, Richard A.

    1997-05-01

    Researchers using biomedical images have data management needs which are oriented perpendicular to clinical PACS. The image BOSS system is designed to permit researchers to organize and select images based on research topic, image metadata, and a thumbnail of the image. Image information is captured from existing images in a Unix based filesystem, stored in an object oriented database, and presented to the user in a familiar laboratory notebook metaphor. In addition, the ImageBOSS is designed to provide an extensible infrastructure for future content-based queries directly on the images.

  20. Multi-channel medical imaging system

    Science.gov (United States)

    Frangioni, John V

    2013-12-31

    A medical imaging system provides simultaneous rendering of visible light and fluorescent images. The system may employ dyes in a small-molecule form that remain in the subject's blood stream for several minutes, allowing real-time imaging of the subject's circulatory system superimposed upon a conventional, visible light image of the subject. The system may provide an excitation light source to excite the fluorescent substance and a visible light source for general illumination within the same optical guide used to capture images. The system may be configured for use in open surgical procedures by providing an operating area that is closed to ambient light. The systems described herein provide two or more diagnostic imaging channels for capture of multiple, concurrent diagnostic images and may be used where a visible light image may be usefully supplemented by two or more images that are independently marked for functional interest.

  1. Development of biomarker specific of pancreatic beta cells (incretin radiolabelled) for image of beta functional mass in diabetic and obese: study in animal model; Desenvolvimento de biomarcador específico de células beta pancreáticas (incretina radiomarcada) para imagem da massa beta funcional em diabéticos e obesos: estudo em modelo animal

    Energy Technology Data Exchange (ETDEWEB)

    Seo, Daniele

    2017-07-01

    Increased prevalence of obesity worldwide, has become a vast concern, stimulating investigations focusing prevention and therapy of this condition. The association of type 2 diabetes or insulin resistance aggravates the prognosis of obesity. Even patients successfully submitted to bariatric or metabolic surgery, may not be cured of diabetes, as improvement of circulating values of glucose and insulin not necessarily reflects recovery of pancreatic beta cell mass. There is no consensus about how to estimate beta cell mass in vivo. Available tools suffer from low sensitivity and specificity, often being as well cumbersome and expensive. Radiolabeled incretins, such as glucagon-like-peptide 1 (GLP-1) analogs, seem to be promising options for the measurement of beta cell mass in diabetes and insulinoma. The objective of this study was the development of two conjugates of GLP-1 analog, radiolabeled with {sup 99m} Technetium, as a noninvasive imaging method for the estimation of pancreatic beta cell mass, in the presence of obesity. Animal models were selected, including hyperlipidic diet-induced obesity, diet restricted obesity, and as controls, alloxan diabetes. Results indicated that both radiotracers achieved over 97% radiochemical yield. The most successful product was {sup 99m}Tc-HYNIC-βAla-Exendin-4. Low beta cell mass uptake occurred in diet-induced obesity. Diet-restricted obesity, with substantial shedding of excess body weight, was followed by remarkable decrease of fasting blood glucose, however beta cell mass uptake was only mildly improved. Future studies are recommended in obesity, type 2 diabetes, and dieting, including bariatric and metabolic operations. (author)

  2. Neutrinoless double beta decay with 82SeF6 and direct ion imaging

    Science.gov (United States)

    Nygren, D. R.; Jones, B. J. P.; López-March, N.; Mei, Y.; Psihas, F.; Renner, J.

    2018-03-01

    We present a new neutrinoless double beta decay concept: the high pressure selenium hexafluoride gas time projection chamber. A promising new detection technique is outlined which combines techniques pioneered in high pressure xenon gas, such as topological discrimination, with the high Q-value afforded by the double beta decay isotope 82Se. The lack of free electrons in SeF6 mandates the use of an ion TPC. The microphysics of ion production and drift, which have many nuances, are explored. Background estimates are presented, suggesting that such a detector may achieve background indices of better than 1 count per ton per year in the region of interest at the 100 kg scale, and still better at the ton-scale.

  3. Optimized computational method for determining the beta dose distribution using a multiple-element thermoluminescent dosimeter system

    International Nuclear Information System (INIS)

    Shen, L.; Levine, S.H.; Catchen, G.L.

    1987-01-01

    This paper describes an optimization method for determining the beta dose distribution in tissue, and it describes the associated testing and verification. The method uses electron transport theory and optimization techniques to analyze the responses of a three-element thermoluminescent dosimeter (TLD) system. Specifically, the method determines the effective beta energy distribution incident on the dosimeter system, and thus the system performs as a beta spectrometer. Electron transport theory provides the mathematical model for performing the optimization calculation. In this calculation, parameters are determined that produce calculated doses for each of the chip/absorber components in the three-element TLD system. The resulting optimized parameters describe an effective incident beta distribution. This method can be used to determine the beta dose specifically at 7 mg X cm-2 or at any depth of interest. The doses at 7 mg X cm-2 in tissue determined by this method are compared to those experimentally determined using an extrapolation chamber. For a great variety of pure beta sources having different incident beta energy distributions, good agreement is found. The results are also compared to those produced by a commonly used empirical algorithm. Although the optimization method produces somewhat better results, the advantage of the optimization method is that its performance is not sensitive to the specific method of calibration

  4. Measurement system study using beta radiation for determining different paper superficial density

    International Nuclear Information System (INIS)

    Vieira, Thais Molina; Madi Filho, Tufic

    2000-01-01

    Radioisotopes are used now in some areas of the industry. For quality control purposes, they are used in non-destructive analysis (NDA) which is applied to the materials examination verifying if they are adequate to the patterns demanded by technical rules or the market. Gamma, beta or neutron radiation sources may be used to do NDA, depending on material to be analyzed and the industrial process. In this work, the study of measurement system applied to quality control area was conceived and, in the evaluation of the material in test, a radioactive beta source was used. A system was designed and mounted, using a plastic scintillator detector developed in the laboratories of the Centro de Tecnologia das Radiacoes from IPEN-CNEN/SP. Two beta sources were used in the operational test: 90 Sr/ 90 Y and 204 Tl. Measures were obtained using several paper samples with different superficial density in g/m 2 . With the results, an equation correlating the relative activity with the superficial density in g/m 2 was established. (author)

  5. Computational methods for analyzing the transmission characteristics of a beta particle magnetic analysis system

    Science.gov (United States)

    Singh, J. J.

    1979-01-01

    Computational methods were developed to study the trajectories of beta particles (positrons) through a magnetic analysis system as a function of the spatial distribution of the radionuclides in the beta source, size and shape of the source collimator, and the strength of the analyzer magnetic field. On the basis of these methods, the particle flux, their energy spectrum, and source-to-target transit times have been calculated for Na-22 positrons as a function of the analyzer magnetic field and the size and location of the target. These data are in studies requiring parallel beams of positrons of uniform energy such as measurement of the moisture distribution in composite materials. Computer programs for obtaining various trajectories are included.

  6. Clinical and cost implications of amyloid beta detection with amyloid beta positron emission tomography imaging in early Alzheimer's disease - the case of florbetapir.

    Science.gov (United States)

    Hornberger, John; Bae, Jay; Watson, Ian; Johnston, Joe; Happich, Michael

    2017-04-01

    Amyloid beta (Aβ) positron emission tomography (PET) imaging helps estimate Aβ neuritic plaque density in patients with cognitive impairment who are under evaluation for Alzheimer's disease (AD). This study aims to evaluate the cost-effectiveness of the Aβ-PET scan as an adjunct to standard diagnostic assessment for diagnosis of AD in France, using florbetapir as an example. A state-transition probability analysis was developed adopting the French Health Technology Assessment (HTA) perspective per guidance. Parameters included test characteristics, rate of cognitive decline, treatment effect, costs, and quality of life. Additional scenarios assessed the validity of the analytical framework, including: (1) earlier evaluation/treatment; (2) cerebrospinal fluid (CSF) as a comparator; and (3) use of other diagnostic procedures. Outputs included differences in quality-adjusted life years (QALYs), costs, and incremental cost-effectiveness ratios (ICERs). All benefits and costs were discounted for time preferences. Sensitivity analyses were performed to assess the robustness of findings and key influencers of outcomes. Aβ-PET used as an adjunct to standard diagnostic assessment increased QALYs by 0.021 years and 10 year costs by €470 per patient. The ICER was €21,888 per QALY gained compared to standard diagnostic assessment alone. When compared with CSF, Aβ-PET costs €24,084 per QALY gained. In other scenarios, Aβ-PET was consistently cost-effective relative to the commonly used affordability threshold (€40,000 per QALY). Over 95% of simulations in the sensitivity analysis were cost-effective. Aβ-PET is projected to affordably increase QALYs from the French HTA perspective per guidance over a range of clinical scenarios, comparators, and input parameters.

  7. THE NEW METALL-BETA-LACTAMASE’S INHIBITOR EFFICACY IN A MODEL SYSTEM IN VITRO

    Directory of Open Access Journals (Sweden)

    A. G. Afinogenova

    2016-01-01

    Full Text Available The Enterobacteriaceae antibiotics resistance depends on a combination of several mechanisms, such as the beta-lactamases overproduction, the microbial cell reduction outer membrane permeability (usually associated with loss of protein porin, the presence of efflux systems. Particularly noteworthy are the metallo-beta-lactamases (MBL whose presence causes resistance of gram-negative microorganisms to all beta-lactam antibiotics (in some cases except aztreonam. Currently there are no MBL inhibitors permitted for use in the clinic. The effective inhibitors search for carbapenem-resistant bacteria’ MBL authorized for use in the clinic and reinforcing effects of carbapenems, served as the basis for the present study. The work was carried out in three stages: 1 creating a model system using a standard enzyme reagent metallo-beta-lactamase P. aeruginosa recombinant expressed in E. coli, to evaluate the increasing of minimal inhibitory concentrations (MIC of carbapenems against previously sensitive Gram-negative microorganisms strains in vitro; 2 evaluation of MBL promising inhibitors in the presence of the same standard enzyme reagent; 3 evaluation of the ability of the identified inhibitors increase the carbapenems effects against clinical isolates of Gram-negative microorganisms producing MBL, in terms of the their MIC and fractional inhibitory concentration index (FIC index. The checkerboard array was modified to evaluate the combined use of carbapenems and potential MBL inhibitor — a drug from the group of bisphosphonates — etidronic acid. Using a standard enzyme reagent metallo-beta-lactamase P. aeruginosa recombinant expressed in E. coli, we created a model system that allows to assess the prospects of new inhibitors MBL gram-negative microorganisms. A dose-dependent effect of increasing the meropenem level MIC from reagent MBL quantity in a model system against previously antibiotic sensitive reference strains of microorganisms was

  8. High dynamic range coding imaging system

    Science.gov (United States)

    Wu, Renfan; Huang, Yifan; Hou, Guangqi

    2014-10-01

    We present a high dynamic range (HDR) imaging system design scheme based on coded aperture technique. This scheme can help us obtain HDR images which have extended depth of field. We adopt Sparse coding algorithm to design coded patterns. Then we utilize the sensor unit to acquire coded images under different exposure settings. With the guide of the multiple exposure parameters, a series of low dynamic range (LDR) coded images are reconstructed. We use some existing algorithms to fuse and display a HDR image by those LDR images. We build an optical simulation model and get some simulation images to verify the novel system.

  9. Improved Interactive Medical-Imaging System

    Science.gov (United States)

    Ross, Muriel D.; Twombly, Ian A.; Senger, Steven

    2003-01-01

    An improved computational-simulation system for interactive medical imaging has been invented. The system displays high-resolution, three-dimensional-appearing images of anatomical objects based on data acquired by such techniques as computed tomography (CT) and magnetic-resonance imaging (MRI). The system enables users to manipulate the data to obtain a variety of views for example, to display cross sections in specified planes or to rotate images about specified axes. Relative to prior such systems, this system offers enhanced capabilities for synthesizing images of surgical cuts and for collaboration by users at multiple, remote computing sites.

  10. Radionuclide Imaging Technologies for Biological Systems

    Energy Technology Data Exchange (ETDEWEB)

    Howell, Calvin R. [Duke Univ., Durham, NC (United States); Reid, Chantal D. [Duke Univ., Durham, NC (United States); Weisenberger, Andrew G. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States)

    2014-05-14

    The main objective of this project is to develop technologies and experimental techniques for studying the dynamics of physiological responses of plants to changes in their interface with the local environment and to educate a new generation of scientists in an interdisciplinary environment of biology, physics and engineering. Also an important goal is to perform measurements to demonstrate the new data that can be produced and made available to the plant-biology community using the imaging technologies and experimental techniques developed in this project. The study of the plant-environment interface includes a wide range of topics in plant physiology, e.g., the root-soil interface, resource availability, impact of herbivores, influence of microbes on root surface, and responses to toxins in the air and soil. The initial scientific motivation for our work is to improve understanding of the mechanisms for physiological responses to abrupt changes in the local environment, in particular, the responses that result in short-term adjustments in resource (e.g., sugars, nutrients and water) allocations. Data of time-dependent responses of plants to environmental changes are essential in developing mechanistic models for substance intake and resource allocation. Our approach is to use radioisotope tracing techniques to study whole-plant and plant organ (e.g., leaves, stems, roots) dynamical responses to abrupt changes in environmental conditions such as concentration of CO2 in the atmosphere, nutrient availability and lighting. To this aim we are collaborating with the Radiation Detector and Imaging Group at the Thomas Jefferson National Laboratory Facility (JLab) to develop gamma-ray and beta particle imaging systems optimized for plant studies. The radioisotope tracing measurements are conducted at the Phytotron facility at Duke University. The Phytotron is a controlled environment plant research facility with a variety of plant growth chambers. One chamber

  11. Imaging systems in nuclear medicine and image evaluation

    International Nuclear Information System (INIS)

    Beck, R.; Charleston, D.; Metz, C.; Tsui, B.

    1981-01-01

    A general computer code to simulate the imaging properties of existing and hypothetical imaging systems viewing realistic source distributions within non-uniform media. Such a code allows comparative evaluations of existing and hypothetical systems, and optimization of critical parameters of system design by maximizing the signal-to-noise ratio. To be most useful, such a code allows simulation of conventional scintillation scanners and cameras as well as single-photon and position tomographic systems

  12. Simulation of complex detection systems in neutrinoless double beta decay experiments

    International Nuclear Information System (INIS)

    Larrea, A.; Morales, A.; Morales, J.; Nunez-Lagos, R.; Puimedon, J.; Villar, J.A.

    1988-01-01

    The estimated efficiency of several detection systems dedicated to the search of the neutrinoless double beta decay of 76 Ge is reported. In order to perform this work, we have developed the GEOM macro library system which can handle highly complex geometries in simulation problems, allowing to include an accurate description of the experimental setup in a very simple way. Also an internal mechanism for checking the correct location of every boundary defining the geometrical regions is included. The present version of GEOM is implemented in the EGS4 code of Monte Carlo simulation of photons and electron/positron showers, but it can be easily extended to other simulation codes. (orig.)

  13. Highly integrated image sensors enable low-cost imaging systems

    Science.gov (United States)

    Gallagher, Paul K.; Lake, Don; Chalmers, David; Hurwitz, J. E. D.

    1997-09-01

    The highest barriers to wide scale implementation of vision systems have been cost. This is closely followed by the level of difficulty of putting a complete imaging system together. As anyone who has every been in the position of creating a vision system knows, the various bits and pieces supplied by the many vendors are not under any type of standardization control. In short, unless you are an expert in imaging, electrical interfacing, computers, digital signal processing, and high speed storage techniques, you will likely spend more money trying to do it yourself rather than to buy the exceedingly expensive systems available. Another alternative is making headway into the imaging market however. The growing investment in highly integrated CMOS based imagers is addressing both the cost and the system integration difficulties. This paper discusses the benefits gained from CMOS based imaging, and how these benefits are already being applied.

  14. Principal Typings in a Restricted Intersection Type System for Beta Normal Forms with De Bruijn Indices

    Directory of Open Access Journals (Sweden)

    Daniel Ventura

    2010-01-01

    Full Text Available The lambda-calculus with de Bruijn indices assembles each alpha-class of lambda-terms in a unique term, using indices instead of variable names. Intersection types provide finitary type polymorphism and can characterise normalisable lambda-terms through the property that a term is normalisable if and only if it is typeable. To be closer to computations and to simplify the formalisation of the atomic operations involved in beta-contractions, several calculi of explicit substitution were developed mostly with de Bruijn indices. Versions of explicit substitutions calculi without types and with simple type systems are well investigated in contrast to versions with more elaborate type systems such as intersection types. In previous work, we introduced a de Bruijn version of the lambda-calculus with an intersection type system and proved that it preserves subject reduction, a basic property of type systems. In this paper a version with de Bruijn indices of an intersection type system originally introduced to characterise principal typings for beta-normal forms is presented. We present the characterisation in this new system and the corresponding versions for the type inference and the reconstruction of normal forms from principal typings algorithms. We briefly discuss the failure of the subject reduction property and some possible solutions for it.

  15. Development of dose calibrators Tandem systems and establishment of beta dosimetry in nuclear medicine

    International Nuclear Information System (INIS)

    Cecatti, Sonia Garcia Pereira

    2004-01-01

    A quality control program at Nuclear Medicine Services includes the checking of all equipment used for diagnostics and treatment, and the individual monitoring of the workers occupationally exposed to ionizing radiations. In this work the main quality control tests were performed with three dose calibrators using standard radiation sources of 57 Co, 133 Ba, 137 Cs and 60 Co. Tandem systems of dose calibrators were established and characterized using four cylindrical absorbers of different materials for an additional quality control test in Nuclear Medicine. The main utility of this new test is the possibility of impurity detection in radiopharmaceuticals, when the ratio of the measurements with different absorbers is different from that obtained at the laboratory in ideal conditions. The dosimetric characteristics of three types of CaS0 4 :Dy + Teflon pellets were studied for an appropriate choice of the material to be used for individual monitoring of workers. The thermoluminescent detectors were irradiated using beta sources of 90 Sr+ 90 Y, 204 TI, 147 Pm, 153 Sm and 32 P. A wrist badge for beta individual monitoring was developed for workers that handle beta radiopharmaceuticals in Nuclear Medicine Services. (author)

  16. Handheld microwave bomb-detecting imaging system

    Science.gov (United States)

    Gorwara, Ashok; Molchanov, Pavlo

    2017-05-01

    Proposed novel imaging technique will provide all weather high-resolution imaging and recognition capability for RF/Microwave signals with good penetration through highly scattered media: fog, snow, dust, smoke, even foliage, camouflage, walls and ground. Image resolution in proposed imaging system is not limited by diffraction and will be determined by processor and sampling frequency. Proposed imaging system can simultaneously cover wide field of view, detect multiple targets and can be multi-frequency, multi-function. Directional antennas in imaging system can be close positioned and installed in cell phone size handheld device, on small aircraft or distributed around protected border or object. Non-scanning monopulse system allows dramatically decrease in transmitting power and at the same time provides increased imaging range by integrating 2-3 orders more signals than regular scanning imaging systems.

  17. Bone marrow changes in beta-thalassemia major: quantitative MR imaging findings and correlation with iron stores

    International Nuclear Information System (INIS)

    Drakonaki, Eleni E.; Karantanas, Apostolos H.; Maris, Thomas G.; Papadakis, Alex

    2007-01-01

    The purpose of this study is to describe the MR imaging features of bone marrow in beta-thalassemia major and investigate their relation to ferritin, liver and spleen siderosis. Spinal bone marrow was prospectively assessed on abdominal MR studies of 40 transfused beta-thalassemic patients and 15 controls using T1-w, Pd, T2*-w Gradient Echo (GRE) and T1-w turbo Spin Echo (TSE) sequences. Signal intensity (SI) ratios of liver, spleen and bone marrow to paraspinous muscles (L/M, S/M, B/M respectively) and the respective T2 relaxation rates (1/T2) were calculated. Serum ferritin levels were recorded. Bone marrow hypointensity in at least T2*-w GRE sequence was noted in 29/40 (72.5%) patients. Eleven/40 patients exhibited normal B/M on all MR sequences. Five/40 patients had normal B/M and low L/M. B/M correlated with L/M in T1-w TSE sequence only (r = 0.471, p = 0.05). B/M correlated with S/M and mean ferritin values in all sequences (r > 0.489, p - 0.496, p < 0.03 respectively). Marrow 1/T2 did not correlate with ferritin values or liver and spleen 1/T2. B/M in transfused beta-thalassemic patients is related to splenic siderosis and ferritin levels. Although marrow is usually hypointense, it may occasionally display normal SI coexisting with liver hypointensity, a pattern typical of primary hemochromatosis. (orig.)

  18. Bone marrow changes in beta-thalassemia major: quantitative MR imaging findings and correlation with iron stores

    Energy Technology Data Exchange (ETDEWEB)

    Drakonaki, Eleni E.; Karantanas, Apostolos H. [University Hospital of Heraklion, Radiology Department, Heraklion, Crete (Greece); Maris, Thomas G. [University of Crete, Department of Medical Physics, Heraklion, Crete (Greece); Papadakis, Alex [Venizelion General Hospital, Heraklion, Crete (Greece)

    2007-08-15

    The purpose of this study is to describe the MR imaging features of bone marrow in beta-thalassemia major and investigate their relation to ferritin, liver and spleen siderosis. Spinal bone marrow was prospectively assessed on abdominal MR studies of 40 transfused beta-thalassemic patients and 15 controls using T1-w, Pd, T2*-w Gradient Echo (GRE) and T1-w turbo Spin Echo (TSE) sequences. Signal intensity (SI) ratios of liver, spleen and bone marrow to paraspinous muscles (L/M, S/M, B/M respectively) and the respective T2 relaxation rates (1/T2) were calculated. Serum ferritin levels were recorded. Bone marrow hypointensity in at least T2*-w GRE sequence was noted in 29/40 (72.5%) patients. Eleven/40 patients exhibited normal B/M on all MR sequences. Five/40 patients had normal B/M and low L/M. B/M correlated with L/M in T1-w TSE sequence only (r = 0.471, p = 0.05). B/M correlated with S/M and mean ferritin values in all sequences (r > 0.489, p < 0.01 and r > - 0.496, p < 0.03 respectively). Marrow 1/T2 did not correlate with ferritin values or liver and spleen 1/T2. B/M in transfused beta-thalassemic patients is related to splenic siderosis and ferritin levels. Although marrow is usually hypointense, it may occasionally display normal SI coexisting with liver hypointensity, a pattern typical of primary hemochromatosis. (orig.)

  19. Digital image display system for emergency room

    International Nuclear Information System (INIS)

    Murry, R.C.; Lane, T.J.; Miax, L.S.

    1989-01-01

    This paper reports on a digital image display system for the emergency room (ER) in a major trauma hospital. Its objective is to reduce radiographic image delivery time to a busy ER while simultaneously providing a multimodality capability. Image storage, retrieval, and display will also be facilitated with this system. The system's backbone is a token-ring network of RISC and personal computers. The display terminals are higher- function RISC computers with 1,024 2 color or gray-scale monitors. The PCs serve as administrative terminals. Nuclear medicine, CT, MR, and digitized film images are transferred to the image display system

  20. A fractal-based image encryption system

    KAUST Repository

    Abd-El-Hafiz, S. K.; Radwan, Ahmed Gomaa; Abdel Haleem, Sherif H.; Barakat, Mohamed L.

    2014-01-01

    single-fractal image and statistical analysis is performed. A general encryption system utilising multiple fractal images is, then, introduced to improve the performance and increase the encryption key up to hundreds of bits. This improvement is achieved

  1. Objective analysis of image quality of video image capture systems

    Science.gov (United States)

    Rowberg, Alan H.

    1990-07-01

    As Picture Archiving and Communication System (PACS) technology has matured, video image capture has become a common way of capturing digital images from many modalities. While digital interfaces, such as those which use the ACR/NEMA standard, will become more common in the future, and are preferred because of the accuracy of image transfer, video image capture will be the dominant method in the short term, and may continue to be used for some time because of the low cost and high speed often associated with such devices. Currently, virtually all installed systems use methods of digitizing the video signal that is produced for display on the scanner viewing console itself. A series of digital test images have been developed for display on either a GE CT9800 or a GE Signa MRI scanner. These images have been captured with each of five commercially available image capture systems, and the resultant images digitally transferred on floppy disk to a PC1286 computer containing Optimast' image analysis software. Here the images can be displayed in a comparative manner for visual evaluation, in addition to being analyzed statistically. Each of the images have been designed to support certain tests, including noise, accuracy, linearity, gray scale range, stability, slew rate, and pixel alignment. These image capture systems vary widely in these characteristics, in addition to the presence or absence of other artifacts, such as shading and moire pattern. Other accessories such as video distribution amplifiers and noise filters can also add or modify artifacts seen in the captured images, often giving unusual results. Each image is described, together with the tests which were performed using them. One image contains alternating black and white lines, each one pixel wide, after equilibration strips ten pixels wide. While some systems have a slew rate fast enough to track this correctly, others blur it to an average shade of gray, and do not resolve the lines, or give

  2. Characterization of lens based photoacoustic imaging system

    Directory of Open Access Journals (Sweden)

    Kalloor Joseph Francis

    2017-12-01

    Full Text Available Some of the challenges in translating photoacoustic (PA imaging to clinical applications includes limited view of the target tissue, low signal to noise ratio and the high cost of developing real-time systems. Acoustic lens based PA imaging systems, also known as PA cameras are a potential alternative to conventional imaging systems in these scenarios. The 3D focusing action of lens enables real-time C-scan imaging with a 2D transducer array. In this paper, we model the underlying physics in a PA camera in the mathematical framework of an imaging system and derive a closed form expression for the point spread function (PSF. Experimental verification follows including the details on how to design and fabricate the lens inexpensively. The system PSF is evaluated over a 3D volume that can be imaged by this PA camera. Its utility is demonstrated by imaging phantom and an ex vivo human prostate tissue sample.

  3. Characterization of lens based photoacoustic imaging system.

    Science.gov (United States)

    Francis, Kalloor Joseph; Chinni, Bhargava; Channappayya, Sumohana S; Pachamuthu, Rajalakshmi; Dogra, Vikram S; Rao, Navalgund

    2017-12-01

    Some of the challenges in translating photoacoustic (PA) imaging to clinical applications includes limited view of the target tissue, low signal to noise ratio and the high cost of developing real-time systems. Acoustic lens based PA imaging systems, also known as PA cameras are a potential alternative to conventional imaging systems in these scenarios. The 3D focusing action of lens enables real-time C-scan imaging with a 2D transducer array. In this paper, we model the underlying physics in a PA camera in the mathematical framework of an imaging system and derive a closed form expression for the point spread function (PSF). Experimental verification follows including the details on how to design and fabricate the lens inexpensively. The system PSF is evaluated over a 3D volume that can be imaged by this PA camera. Its utility is demonstrated by imaging phantom and an ex vivo human prostate tissue sample.

  4. Analysis of image plane's Illumination in Image-forming System

    International Nuclear Information System (INIS)

    Duan Lihua; Zeng Yan'an; Zhang Nanyangsheng; Wang Zhiguo; Yin Shiliang

    2011-01-01

    In the detection of optical radiation, the detecting accuracy is affected by optic power distribution of the detector's surface to a large extent. In addition, in the image-forming system, the quality of the image is greatly determined by the uniformity of the image's illumination distribution. However, in the practical optical system, affected by the factors such as field of view, false light and off axis and so on, the distribution of the image's illumination tends to be non uniform, so it is necessary to discuss the image plane's illumination in image-forming systems. In order to analyze the characteristics of the image-forming system at a full range, on the basis of photometry, the formulas to calculate the illumination of the imaging plane have been summarized by the numbers. Moreover, the relationship between the horizontal offset of the light source and the illumination of the image has been discussed in detail. After that, the influence of some key factors such as aperture angle, off-axis distance and horizontal offset on illumination of the image has been brought forward. Through numerical simulation, various theoretical curves of those key factors have been given. The results of the numerical simulation show that it is recommended to aggrandize the diameter of the exit pupil to increase the illumination of the image. The angle of view plays a negative role in the illumination distribution of the image, that is, the uniformity of the illumination distribution can be enhanced by compressing the angle of view. Lastly, it is proved that telecentric optical design is an effective way to advance the uniformity of the illumination distribution.

  5. Fluoroscopic Imaging Systems. Chapter 8

    Energy Technology Data Exchange (ETDEWEB)

    Jones, A. K. [University of Texas MD Anderson Cancer Center, Houston (United States)

    2014-09-15

    Fluoroscopy refers to the use of an X ray beam and a suitable image receptor for viewing images of processes or instruments in the body in real time. Fluoroscopic imaging trades the high signal to noise ratio (SNR) of radiography for high temporal resolution, as factors that maintain patient dose at an acceptable level must be used.

  6. Post-movement beta rebound abnormality as indicator of mirror neuron system dysfunction in autistic spectrum disorder: an MEG study.

    Science.gov (United States)

    Honaga, Eiko; Ishii, Ryouhei; Kurimoto, Ryu; Canuet, Leonides; Ikezawa, Koji; Takahashi, Hidetoshi; Nakahachi, Takayuki; Iwase, Masao; Mizuta, Ichiro; Yoshimine, Toshiki; Takeda, Masatoshi

    2010-07-12

    The mu rhythm is regarded as a physiological indicator of the human mirror neuron system (MNS). The dysfunctional MNS hypothesis in patients with autistic spectrum disorder (ASD) has often been tested using EEG and MEG, targeting mu rhythm suppression during action observation/execution, although with controversial results. We explored neural activity related to the MNS in patients with ASD, focusing on power increase in the beta frequency band after observation and execution of movements, known as post-movement beta rebound (PMBR). Multiple source beamformer (MSBF) and BrainVoyager QX were used for MEG source imaging and statistical group analysis, respectively. Seven patients with ASD and ten normal subjects participated in this study. During the MEG recordings, the subjects were asked to observe and later execute object-related hand actions performed by an experimenter. We found that both groups exhibited pronounced PMBR exceeding 20% when observing and executing actions with a similar topographic distribution of maximal activity. However, significantly reduced PMBR was found only during the observation condition in the patients relative to controls in cortical regions within the MNS, namely the sensorimotor area, premotor cortex and superior temporal gyrus. Reduced PMBR during the observation condition was also found in the medial prefrontal cortex. These results support the notion of a dysfunctional execution/observation matching system related to MNS impairment in patients with ASD, and the feasibility of using MEG to detect neural activity, in particular PMBR abnormalities, as an index of MNS dysfunction during performance of motor or cognitive tasks. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.

  7. Water mobility in the endosperm of high beta-glucan barley mutants as studied by nuclear magnetic resonance imaging

    DEFF Research Database (Denmark)

    Seefeldt, Helene Fast; van den Berg, Frans W.J.; Köckenberger, Walter

    2007-01-01

    1H NMR imaging (MRI) was used as a noninvasive technique to study water distribution and mobility in hydrated barley (Hordeum vulgare L.) seeds of accessions with varying content of beta glucan (BG), a highly hygroscopic cell wall component. High contents of BG in barley are unfavorable in malting...... where it leads to clotting of filters and hazing of beer as well as in animal feed where it hinders the rapid uptake of energy. However, a high content of BG has a positive nutritional effect, as it lowers the cholesterol and the glycaemic index. It was studied whether water distribution and mobility...... were related to content and location of BG. Water mobility was investigated by following the rate and mode of desiccation in hydrated single seeds. In order to determine the different water components, a multispin echo experiment was set up to reveal the T2 transverse relaxation rates of water within...

  8. Quantifying the pattern of beta/A4 amyloid protein distribution in Alzheimer's disease by image analysis.

    Science.gov (United States)

    Bruce, C V; Clinton, J; Gentleman, S M; Roberts, G W; Royston, M C

    1992-04-01

    We have undertaken a study of the distribution of the beta/A4 amyloid deposited in the cerebral cortex in Alzheimer's disease. Previous studies which have examined the differential distribution of amyloid in the cortex in order to determine the laminar pattern of cortical pathology have not proved to be conclusive. We have developed an alternative method for the solution of this problem. It involves the immunostaining of sections followed by computer-enhanced image analysis. A mathematical model is then used to describe both the amount and the pattern of amyloid across the cortex. This method is both accurate and reliable and also removes many of the problems concerning inter and intra-rater variability in measurement. This method will provide the basis for further quantitative studies on the differential distribution of amyloid in Alzheimer's disease and other cases of dementia where cerebral amyloidosis occurs.

  9. Developing stereo image based robot control system

    Energy Technology Data Exchange (ETDEWEB)

    Suprijadi,; Pambudi, I. R.; Woran, M.; Naa, C. F; Srigutomo, W. [Department of Physics, FMIPA, InstitutTeknologi Bandung Jl. Ganesha No. 10. Bandung 40132, Indonesia supri@fi.itb.ac.id (Indonesia)

    2015-04-16

    Application of image processing is developed in various field and purposes. In the last decade, image based system increase rapidly with the increasing of hardware and microprocessor performance. Many fields of science and technology were used this methods especially in medicine and instrumentation. New technique on stereovision to give a 3-dimension image or movie is very interesting, but not many applications in control system. Stereo image has pixel disparity information that is not existed in single image. In this research, we proposed a new method in wheel robot control system using stereovision. The result shows robot automatically moves based on stereovision captures.

  10. Energy response of imaging plates to radiation beams from standard beta sources, ortho-voltage and cobalt-60 units and linear accelerators

    Science.gov (United States)

    Gonzalez, Albin Leonel

    The response to different types of radiation beams of commercial imaging plates used for diagnostic computed radiography has been investigated in this work. Imaging plates are designed with a phosphor layer which after been irradiated; information is stored in the form of photostimulable luminescence (PSL) centers. Initial measurements of the dose distribution of a radioactive stent with the imaging plates showed similar results to those with radiochromic films, but with much shorter exposure time due to their higher sensitivity. In order to investigate further their response, the imaging plates were irradiated with calibrated beams from: standard beta sources, orthovoltage and Co-60 units and therapy linear accelerator. Initially it was found that the energy to create the storage centers (generation efficiency) when irradiated with the three standard beta sources (225 keV to 2.28 MeV) was the same. For the rest of the calibrated beams an in house reader system was built in order to perform the bleaching of the plates with a He-Ne laser (632.8 nm) and to measure the absolute number of the emitted PSL photons (storage centers produced). Bleaching curves were then obtained for different exposure times for each beam. From the graph of the calculated area under the bleaching curves (total number of storage center) versus the absorbed dose to the phosphor layer it was possible to calculate the energy to create the storage centers (generation efficiency) for photon and electron beams. The dose to the phosphor layer was calculated in the case of the electron beams following a scaling procedure, while in the case of the photon beams Monte Carlo simulations were performed. For the photons beams the measurement of the generation efficiency energy of 126 +/- 8% eV per PSL storage center, coincide with measurements using a different approach (˜148 eV) by previous investigators. The generation efficiency for the electron beam was 807 +/- 3% eV, no reference was found in the

  11. Design and construction of an interface system for the extrapolation chamber from the beta secondary standard

    International Nuclear Information System (INIS)

    Jimenez C, L.F.

    1995-01-01

    The Interface System for the Extrapolation Chamber (SICE) contains several devices handled by a personal computer (PC), it is able to get the required data to calculate the absorbed dose due to Beta radiation. The main functions of the system are: a) Measures the ionization current or charge stored in the extrapolation chamber. b) Adjusts the distance between the plates of the extrapolation chamber automatically. c) Adjust the bias voltage of the extrapolation chamber automatically. d) Acquires the data of the temperature, atmospheric pressure, relative humidity of the environment and the voltage applied between the plates of the extrapolation chamber. e) Calculates the effective area of the plates of the extrapolation chamber and the real distance between them. f) Stores all the obtained information in hard disk or diskette. A comparison between the desired distance and the distance in the dial of the extrapolation chamber, show us that the resolution of the system is of 20 μm. The voltage can be changed between -399.9 V and +399.9 V with an error of less the 3 % with a resolution of 0.1 V. These uncertainties are between the accepted limits to be used in the determination of the absolute absorbed dose due to beta radiation. (Author)

  12. Image portion identification methods, image parsing methods, image parsing systems, and articles of manufacture

    Science.gov (United States)

    Lassahn, Gordon D.; Lancaster, Gregory D.; Apel, William A.; Thompson, Vicki S.

    2013-01-08

    Image portion identification methods, image parsing methods, image parsing systems, and articles of manufacture are described. According to one embodiment, an image portion identification method includes accessing data regarding an image depicting a plurality of biological substrates corresponding to at least one biological sample and indicating presence of at least one biological indicator within the biological sample and, using processing circuitry, automatically identifying a portion of the image depicting one of the biological substrates but not others of the biological substrates.

  13. Transfer function analysis of radiographic imaging systems

    International Nuclear Information System (INIS)

    Metz, C.E.; Doi, K.

    1979-01-01

    The theoretical and experimental aspects of the techniques of transfer function analysis used in radiographic imaging systems are reviewed. The mathematical principles of transfer function analysis are developed for linear, shift-invariant imaging systems, for the relation between object and image and for the image due to a sinusoidal plane wave object. The other basic mathematical principle discussed is 'Fourier analysis' and its application to an input function. Other aspects of transfer function analysis included are alternative expressions for the 'optical transfer function' of imaging systems and expressions are derived for both serial and parallel transfer image sub-systems. The applications of transfer function analysis to radiographic imaging systems are discussed in relation to the linearisation of the radiographic imaging system, the object, the geometrical unsharpness, the screen-film system unsharpness, other unsharpness effects and finally noise analysis. It is concluded that extensive theoretical, computer simulation and experimental studies have demonstrated that the techniques of transfer function analysis provide an accurate and reliable means for predicting and understanding the effects of various radiographic imaging system components in most practical diagnostic medical imaging situations. (U.K.)

  14. Multispectral system for medical fluorescence imaging

    International Nuclear Information System (INIS)

    Andersson, P.S.; Montan, S.; Svanberg, S.

    1987-01-01

    The principles of a powerful multicolor imaging system for tissue fluorescence diagnostics are discussed. Four individually spectrally filtered images are formed on a matrix detector by means of a split-mirror arrangement. The four images are processed in a computer, pixel by pixel, by means of mathematical operations, leading to an optimized contrast image, which enhances a selected feature. The system is being developed primarily for medical fluorescence imaging, but has wide applications in fluorescence, reflectance, and transmission monitoring related to a wide range of industrial and environmental problems. The system operation is described for the case of linear imaging on a diode array detector. Laser-induced fluorescence is used for cancer tumor and arteriosclerotic plaque demarcation using the contrast enhancement capabilities of this imaging system. Further examples of applications include fluorescing minerals and flames

  15. SPEAR-BETA fuel-performance code system: fission-gas-release module. Final report

    International Nuclear Information System (INIS)

    Christensen, R.

    1983-03-01

    The original SPEAR-BETA general description manual covers both mechanistic and statistical models for fuel reliability, but only mechanistic modeling of fission gas release. This addendum covers the SPEAR-BETA statistical model for fission gas release

  16. 3D images and expert system

    International Nuclear Information System (INIS)

    Hasegawa, Jun-ichi

    1998-01-01

    This paper presents an expert system called 3D-IMPRESS for supporting applications of three dimensional (3D) image processing. This system can automatically construct a 3D image processing procedure based on a pictorial example of the goal given by a user. In the paper, to evaluate the performance of the system, it was applied to construction of procedures for extracting specific component figures from practical chest X-ray CT images. (author)

  17. BETA digital beta radiometer

    International Nuclear Information System (INIS)

    Borovikov, N.V.; Kosinov, G.A.; Fedorov, Yu.N.

    1989-01-01

    Portable transportable digital beta radiometer providing for measuring beta-decay radionuclide specific activity in the range from 5x10 -9 up to 10 -6 Cu/kg (Cu/l) with error of ±25% is designed and introduced into commercial production for determination of volume and specific water and food radioactivity. The device specifications are given. Experience in the BETA radiometer application under conditions of the Chernobyl' NPP 30-km zone has shown that it is convenient for measuring specific activity of the order of 10 -8 Cu/kg, and application of a set of different beta detectors gives an opportunity to use it for surface contamination measurement in wide range of the measured value

  18. The Z-isomer of 11 beta-methoxy-17 alpha-[123I]iodovinylestradiol is a promising radioligand for estrogen receptor imaging in human breast cancer

    NARCIS (Netherlands)

    Rijks, L. J.; Boer, G. J.; Endert, E.; de Bruin, K.; Janssen, A. G.; van Royen, E. A.

    1997-01-01

    The potential of both stereoisomers of 11 beta-methoxy-17 alpha-[123I] iodovinylestradiol (E- and Z-[123I]MIVE) as suitable radioligands for imaging of estrogen receptor (ER)-positive human breast tumours was studied. The 17 alpha-[123I]iodovinylestradiol derivatives were prepared stereospecifically

  19. Feasibility of [18F]-RGD for ex vivo imaging of atherosclerosis in detection of alpha v beta 3 integrin expression

    NARCIS (Netherlands)

    Golestani, Reza; Mirfeizi, Leila; Zeebregts, Clark J.; Westra, Johanna; de Haas, Hans J.; Glaudemans, Andor W. J. M.; Koole, Michel; Luurtsema, Gert; Tio, Rene A.; Dierckx, Rudi A. J. O.; Boersma, Hendrikus H.; Elsinga, Philip H.; Slart, Riemer H. J. A.

    2015-01-01

    Background. Inflammation and angiogenesis play an important role in atherosclerotic plaque rupture. Therefore, molecular imaging of these processes could be used for determination of rupture-prone atherosclerotic plaques. alpha v beta 3 integrin is involved in the process of angiogenesis. Targeted

  20. Flow imaging of the cardiovascular system using magnetic resonance imaging

    International Nuclear Information System (INIS)

    Imai, Hitoshi; Sakakibara, Makoto; Sunami, Yuko

    1988-01-01

    Blood flow images by magnetic resonance imaging (MRI) using a 0.25 T unit were evaluated for nine normal volunteers and 108 subjects with a variety of cardiovascular abnormalities. Using the non-gated short-spin echo (SE) technique, blood flow in the cardiovascular systems was not imaged in the normal volunteers. Using end-systolic and end-diastolic SE techniques for the normal subjects, blood flow in the cardiac chambers was not clearly imaged. Blood flow in the ascending aorta and aortic arch often did not appear in the gated SE images of the normal subjects. However, blood flow in the descending aorta was often observed in the gated SE images. Blood flow imaging was demonstrated by both non-gated and gated SE techniques in regions where blood flow was relatively slow; for example, in the left atrium of mitral stenosis, in an aortic aneurysm, in a false lumen of an aortic dissection, and in the left ventricle having old myocardial infarction. Using the non-gated inversion recovery (IR) technique, no blood flow was imaged in the cardiovascular system except in the left atrium of one case with mitral stenosis. Using the non-gated short SE technique, there was good correlation between the thrombus formation and the presence of blood flow images in the left atria of 17 patients with mitral stenosis, and in the aneurysmal portions of the aorta or in the false lumens of aortic dissection of 18 patients. It was suggested that mural thrombi in such diseases were related to the relatively slow blood flow. Blood flow imaging easily distinguished stagnant blood flow from mural thrombi using non-gated short SE, end-systolic SE, and IR techniques. Thus, blood flow imaging using MRI should become an important means of evaluating the cardiovascular system. (author)

  1. Radioiodinated benzimidazole derivatives as single photon emission computed tomography probes for imaging of {beta}-amyloid plaques in Alzheimer's disease

    Energy Technology Data Exchange (ETDEWEB)

    Cui Mengchao [Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501 (Japan); Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875 (China); Ono, Masahiro, E-mail: ono@pharm.kyoto-u.ac.j [Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501 (Japan); Kimura, Hiroyuki; Kawashima, Hidekazu [Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501 (Japan); Liu Boli [Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875 (China); Saji, Hideo, E-mail: hsaji@pharm.kyoto-u.ac.j [Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501 (Japan)

    2011-04-15

    Five iodinated 2-phenyl-1H-benzo[d]imidazole derivatives were synthesized and evaluated as potential probes for {beta}-amyloid (A{beta}) plaques. One of the compounds, 4-(6-iodo-1H-benzo[d]imidazol-2-yl)-N,N-dimethylaniline (12), showed excellent affinity for A{beta}{sub 1-42} aggregates (K{sub i}=9.8 nM). Autoradiography with sections of postmortem Alzheimer's disease (AD) brain revealed that a radioiodinated probe [{sup 125}I]12, labeled A{beta} plaques selectively with low nonspecific binding. Biodistribution experiments with normal mice injected intravenously with [{sup 125}I]12 showed high uptake [4.14 percent injected dose per gram (% ID/g) at 2 min] into and rapid clearance (0.15% ID/g at 60 min) from the brain, which may bring about a good signal-to-noise ratio and therefore achieve highly sensitive detection of A{beta} plaques. In addition, [{sup 125}I]12 labeled amyloid plaques in vivo in an AD transgenic model. The preliminary results strongly suggest that [{sup 125}I]12 bears characteristics suitable for detecting amyloid plaques in vivo. When labeled with {sup 123}I, it may be a useful SPECT imaging agent for A{beta} plaques in the brain of living AD patients.

  2. Motor System Interactions in the Beta Band Decrease during Loss of Consciousness.

    Science.gov (United States)

    Swann, Nicole C; de Hemptinne, Coralie; Maher, Ryan B; Stapleton, Catherine A; Meng, Lingzhong; Gelb, Adrian W; Starr, Philip A

    2016-01-01

    Communication between brain areas and how they are influenced by changes in consciousness are not fully understood. One hypothesis is that brain areas communicate via oscillatory processes, utilizing network-specific frequency bands, that can be measured with metrics that reflect between-region interactions, such as coherence and phase amplitude coupling (PAC). To evaluate this hypothesis and understand how these interactions are modulated by state changes, we analyzed electrophysiological recordings in humans at different nodes of one well-studied brain network: the basal ganglia-thalamocortical loops of the motor system during loss of consciousness induced by anesthesia. We recorded simultaneous electrocorticography over primary motor cortex (M1) with local field potentials from subcortical motor regions (either basal ganglia or thalamus) in 15 movement disorder patients during anesthesia (propofol) induction as a part of their surgery for deep brain stimulation. We observed reduced coherence and PAC between M1 and the subcortical nuclei, which was specific to the beta band (∼18-24 Hz). The fact that this pattern occurs selectively in beta underscores the importance of this frequency band in the motor system and supports the idea that oscillatory interactions at specific frequencies are related to the capacity for normal brain function and behavior.

  3. Dynamic MR imaging of the musculoskeletal system

    International Nuclear Information System (INIS)

    Shah, A.S.; Hylton, H.; Hentz, V.R.; Schattner, P.

    1991-01-01

    This paper reports on dynamic MR imaging which is an MR technique that allows imaging of the musculoskeletal system in motion. Current methods for observing the articulation of muscles and joints are limited to acquisition of stationary images at different spatial orientations. These images are then replayed from computer memory to simulate motion. Unlike stationary acquisition, dynamic MR imaging allows the volume of interest to be subjected to motion and dynamic stress, which is important for detecting stress-induced pathology. To demonstrate the utility of dynamic MR imaging, a system for imaging a moving wrist has been developed. The system consists of apparatus capable of providing simultaneous radialulnar deviation and flexion-extension, and hardware for system control and acquisition gating. The apparatus is mounted on the patient bed and is transferable to a variety of standard clinical MR imaging systems. Images were obtained during motion, and the ability of dynamic MR imaging to accurately image the moving wrist with very little motion artifact was demonstrated

  4. Cortical Amyloid Beta in Cognitively Normal Elderly Adults is Associated with Decreased Network Efficiency within the Cerebro-Cerebellar System.

    Science.gov (United States)

    Steininger, Stefanie C; Liu, Xinyang; Gietl, Anton; Wyss, Michael; Schreiner, Simon; Gruber, Esmeralda; Treyer, Valerie; Kälin, Andrea; Leh, Sandra; Buck, Alfred; Nitsch, Roger M; Prüssmann, Klaas P; Hock, Christoph; Unschuld, Paul G

    2014-01-01

    Deposition of cortical amyloid beta (Aβ) is a correlate of aging and a risk factor for Alzheimer disease (AD). While several higher order cognitive processes involve functional interactions between cortex and cerebellum, this study aims to investigate effects of cortical Aβ deposition on coupling within the cerebro-cerebellar system. We included 15 healthy elderly subjects with normal cognitive performance as assessed by neuropsychological testing. Cortical Aβ was quantified using (11)carbon-labeled Pittsburgh compound B positron-emission-tomography late frame signals. Volumes of brain structures were assessed by applying an automated parcelation algorithm to three dimensional magnetization-prepared rapid gradient-echo T1-weighted images. Basal functional network activity within the cerebro-cerebellar system was assessed using blood-oxygen-level dependent resting state functional magnetic resonance imaging at the high field strength of 7 T for measuring coupling between cerebellar seeds and cerebral gray matter. A bivariate regression approach was applied for identification of brain regions with significant effects of individual cortical Aβ load on coupling. Consistent with earlier reports, a significant degree of positive and negative coupling could be observed between cerebellar seeds and cerebral voxels. Significant positive effects of cortical Aβ load on cerebro-cerebellar coupling resulted for cerebral brain regions located in inferior temporal lobe, prefrontal cortex, hippocampus, parahippocampal gyrus, and thalamus. Our findings indicate that brain amyloidosis in cognitively normal elderly subjects is associated with decreased network efficiency within the cerebro-cerebellar system. While the identified cerebral regions are consistent with established patterns of increased sensitivity for Aβ-associated neurodegeneration, additional studies are needed to elucidate the relationship between dysfunction of the cerebro-cerebellar system and risk for AD.

  5. Withholding or Continuing Beta-Blocker Treatment Before Dipyridamole Myocardial Perfusion Imaging for the Diagnosis of Coronary Artery Disease? a Randomized Clinical Trial

    Directory of Open Access Journals (Sweden)

    Babak Fallahi

    2013-01-01

    Full Text Available Although it has been shown that acute beta-blocker administration may reduce the presence or severity of myocardial perfusion defects with dipyridamole stress, little information is available about the potential effect of chronic beta-blocker treatment on the sensitivity of dipyridamole myocardial perfusion imaging (DMPI.Methods As a randomized clinical trial, one hundred twenty patients (103 male and 17 female with angiographically confirmed CAD who were on long-term beta blocker therapy ([greater than or equal to]3 months enrolled in a randomized clinical trial study. The patients were allocated into two groups: Group A (n=60 in whom the beta-blocker agent was discontinued for 72h before DMPI and Group B (n=60 without discontinuation of beta-blockers prior to DMPI.ResultsNo significant difference was noted between the groups concerning age, sex, type of the injected radiotracer and number of involved coronary vessels. The mean rank of total perfusion scores for whole myocardium (irrespective of reversibility or irreversibility in group B was not significantly different from that of group A, (65.75 vs. 55.25, P=0.096. Regarding the only irreversible perfusion defects, the mean rank of perfusion score in group B was higher than that of group A for whole myocardium (72 vs. 49, P=0.0001; however, no difference was noted between two groups for only reversible perfusion defects (61.0 vs. 60.0, P=0.898. The overall sensitivity of DMPI for the diagnosis of CAD in group A (91.7% was not statistically different from group B (90%.ConclusionBeta-blocker withholding before DMPI did not generally affect the sensitivity of the test for the diagnostic purposes in our study. Thus, beta-blocker withdrawal for just the purpose of diagnostic imaging is not mandatory particularly when medication discontinuation may cause the patients to face increased risk of heart events.

  6. The role of stress and beta-adrenergic system in melanoma: current knowledge and possible therapeutic options.

    Science.gov (United States)

    Colucci, Roberta; Moretti, Silvia

    2016-05-01

    The aim of the present review was to discuss recent findings on the role of beta-adrenergic system in melanoma, in order to provide information on the biological responses elicited by its activation and its potential application for melanoma treatment. A literature search was performed, and evidences regarding the involvement of stress and beta-adrenergic system in cancer and melanoma were found and discussed. Our search pointed out that beta-adrenergic system is a key regulator of important biological processes involved in the onset and progression of some solid tumors. In the last decade, functional beta-adrenoceptors have been also identified on melanoma cells, as well as on their microenvironment cells. Similarly to other common cancers too, the activation of such adrenoceptors by catecholamines, usually released under stress conditions, has been found to trigger pro-tumorigenic pathways contributing to cell proliferation and motility, immune system regulation, apoptosis, epithelial-mesenchymal transition, invasion and neoangiogenesis. The biological evidences we found clarify and sustain the clinical evidences reporting the involvement of chronic stress in melanoma onset and progression. In such scenario, it is conceivable that a therapeutic approach targeting beta-adrenergic system could constitute a novel and promising strategy for melanoma treatment.

  7. Clinical application of SPECT in adrenal imaging with iodine-131 6 beta-iodomethyl-19-norcholesterol

    International Nuclear Information System (INIS)

    Ishimura, J.; Kawanaka, M.; Fukuchi, M.

    1989-01-01

    Forty-one patients with or without adrenocortical disorders were studied to evaluate the clinical usefulness of SPECT in adrenal imaging with I-131 Adosterol. In the SPECT images from this study, all glands with either normally functioning or hyperfunctioning adrenal cortices could be detected, while those glands with hypofunctioning adrenal cortices could not be detected. Particularly in transaxial and sagittal slices, the adrenal gland was identified posteriorly and was clearly distinguished from the gallbladder. In preliminary results using SPECT by a standard method, uptake in 68 detectable glands ranged from 1.7% to 4.9% in four glands with Cushing's syndrome, from 1.1% to 1.3% in seven glands with primary aldosteronism, and were distributed below 1.0% in the remaining glands with normally functioning adrenal cortices. These data show that it is possible to evaluate the adrenocortical functioning status simply by analyzing the SPECT images of the adrenal

  8. Clinical application of SPECT in adrenal imaging with iodine-131 6 beta-iodomethyl-19-norcholesterol

    Energy Technology Data Exchange (ETDEWEB)

    Ishimura, J.; Kawanaka, M.; Fukuchi, M.

    1989-04-01

    Forty-one patients with or without adrenocortical disorders were studied to evaluate the clinical usefulness of SPECT in adrenal imaging with I-131 Adosterol. In the SPECT images from this study, all glands with either normally functioning or hyperfunctioning adrenal cortices could be detected, while those glands with hypofunctioning adrenal cortices could not be detected. Particularly in transaxial and sagittal slices, the adrenal gland was identified posteriorly and was clearly distinguished from the gallbladder. In preliminary results using SPECT by a standard method, uptake in 68 detectable glands ranged from 1.7% to 4.9% in four glands with Cushing's syndrome, from 1.1% to 1.3% in seven glands with primary aldosteronism, and were distributed below 1.0% in the remaining glands with normally functioning adrenal cortices. These data show that it is possible to evaluate the adrenocortical functioning status simply by analyzing the SPECT images of the adrenal.

  9. Pancreatic iron stores assessed by magnetic resonance imaging (MRI) in beta thalassemic patients

    International Nuclear Information System (INIS)

    Feitosa de Assis, Reijâne Alves; Ribeiro, Andreza Alice; Kay, Fernando Uliana; Rosemberg, Laércio Alberto; Nomura, Cesar Higa; Loggetto, Sandra Regina; Araujo, Aderson S.; Fabron Junior, Antonio; Pinheiro de Almeida Veríssimo, Mônica; Baldanzi, Giorgio Roberto; Espósito, Breno Pannia; Baroni, Ronaldo Hueb; Wood, John C.; Hamerschlak, Nelson

    2012-01-01

    Purpose: To assess the correlation between MRI findings of the pancreas with those of the heart and liver in patients with beta thalassemia; to compare the pancreas T2* MRI results with glucose and ferritin levels and labile plasma iron (LPI). Materials and methods: We retrospectively evaluated chronically transfused patients, testing glucose with enzymatic tests, serum ferritin with chemiluminescence, LPI with cellular fluorescence, and T2* MRI to assess iron content in the heart, liver, and pancreas. MRI results were compared with one another and with serum glucose, ferritin, and LPI. Liver iron concentration (LIC) was determined in 11 patients’ liver biopsies by atomic absorption spectrometry. Results: 289 MRI studies were available from 115 patients during the period studied. 9.4% of patients had overt diabetes and an additional 16% of patients had impaired fasting glucose. Both pancreatic and cardiac R2* had predictive power (p 2 = 0.20, p 2 = 0.09, p 2 = 0.14, p 2 = 0.03, p 2 of 0.91. Conclusions: Pancreatic iron overload can be assessed by MRI, but siderosis in other organs did not correlate significantly with pancreatic hemosiderosis.

  10. Digital image information systems in radiology

    International Nuclear Information System (INIS)

    Greinacher, C.F.C.; Luetke, B.; Seufert, G.

    1987-01-01

    About 25% of all patient examinations are performed digitally in a today's radiological department. A computerized system is described that supports generation, transport, interpretation and archiving of digital radiological images (Picture Archiving and Communication System PACS). The technical features concerning image communication via local area networks, image storage on magnetic and optical media and digital workstations for image display and manipulation are described. A structured system architecture is introduced. It allows flexible adaption to individual organizations and minimizes the requirements of the communication network. (orig.) [de

  11. IMPY, a potential {beta}-amyloid imaging probe for detection of prion deposits in scrapie-infected mice

    Energy Technology Data Exchange (ETDEWEB)

    Song, P.-J. [INSERM, U619, F-37000 Tours (France); Universite Francois-Rabelais, F-37000 Tours (France); IFR135, F-37000 Tours (France); Bernard, Serge [IFR135, F-37000 Tours (France); INRA, UR1282, IASP, 37380 Nouzilly (France)], E-mail: bernard@tours.inra.fr; Sarradin, Pierre [INRA, UR1282, IASP, 37380 Nouzilly (France); Vergote, Jackie [INSERM, U619, F-37000 Tours (France); Universite Francois-Rabelais, F-37000 Tours (France); IFR135, F-37000 Tours (France); Barc, Celine [INRA, UR1282, IASP, 37380 Nouzilly (France); Chalon, Sylvie [INSERM, U619, F-37000 Tours (France); Universite Francois-Rabelais, F-37000 Tours (France); IFR135, F-37000 Tours (France); Kung, M.-P.; Kung, Hank F. [Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104 (United States); Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104 (United States); Guilloteau, Denis [INSERM, U619, F-37000 Tours (France); Universite Francois-Rabelais, F-37000 Tours (France); IFR135, F-37000 Tours (France)

    2008-02-15

    Introduction: A potential single-photon emission computed tomography imaging agent for labeling of A{beta} plaques of Alzheimer's disease, IMPY (2-(4'-dimethylaminophenyl)-6-iodo-imidazo[1,2-a]pyridine), would be effective in detection of prion amyloid deposits in transmissible spongiform encephalopathies (TSEs). Methods: In vitro autoradiographic studies were carried out with [{sup 125}I]IMPY on brain sections from scrapie-infected mice and age-matched controls. Competition study was performed to evaluate the prion deposit binding specificity with nonradioactive IMPY. Results: Binding of [{sup 125}I]IMPY was observed in infected brain sections, while on age-matched control brain sections, there was no or very low labeling. Prion deposit binding was confirmed by histoblots with prion protein-specific monoclonal antibody 2D6. In the presence of nonradioactive IMPY, the binding of [{sup 125}I]IMPY was significantly inhibited in all regions studied. Conclusions: These findings indicate that IMPY can detect the prion deposits in vitro in scrapie-infected mice. Labeled with {sup 123}I, this ligand may be useful to quantitate prion deposit burdens in TSEs by in vivo imaging.

  12. [Comparative study of the central nervous system effect of the beta receptor blockaders pindolol and bisoprolol].

    Science.gov (United States)

    Görtelmeyer, R; Klingmann, I

    1985-01-01

    In a total of 36 volunteers with cardiac hyperreaction, investigations were carried out on the effect of bisoprolol (designated tradename: Concor), pindolol and placebo on central nervous functions with the aid of a reaction test, spiral aftereffect, tremor test and mood and sleep questionnaires. In the randomized double-blind study performed with 3 independent groups the volunteers received placebo, 2 X daily 10 mg of pindolol or 1 X daily 10 mg of bisoprolol for a period of 14 days. Bisoprolol is a new highly beta 1-selective adrenoceptor blocker with moderate lipophilia and without intrinsic sympathomimetic activity (ISA). When compared to placebo neither of the beta-adrenoceptor blockers induced any significant changes in mood, vigilance, tremor and reaction times. Moreover, under bisoprolol no negative effect on sleep quality or feeling refreshed after sleep was determined. Under pindolol, on the other hand, a significant impairment of sleep quality was observed after acute dosage and a decrease in feeling refreshed after sleep, continuing up to day 14 of treatment. It is presumed that, as bisoprolol and pindolol have comparable lipophilia, the different intensity with which the two preparations act on the central nervous system is connected with the ISA of pindolol. In the selected doses bisoprolol had a stronger effect on diastolic blood pressure and heart rate than pindolol and placebo.

  13. Beta-carotene reduces oxidative stress, improves glutathione metabolism and modifies antioxidant defense systems in lead-exposed workers

    International Nuclear Information System (INIS)

    Kasperczyk, Sławomir; Dobrakowski, Michał; Kasperczyk, Janusz; Ostałowska, Alina; Zalejska-Fiolka, Jolanta; Birkner, Ewa

    2014-01-01

    The aim of this study was to determine whether beta-carotene administration reduces oxidative stress and influences antioxidant, mainly glutathione-related, defense systems in workers chronically exposed to lead. The population consisted of two randomly divided groups of healthy male volunteers exposed to lead. Workers in the first group (reference group) were not administered any antioxidants, while workers in the second group (CAR group) were treated orally with 10 mg of beta-carotene once a day for 12 weeks. Biochemical analysis included measuring markers of lead-exposure and oxidative stress in addition to the levels and activities of selected antioxidants. After treatment, levels of malondialdehyde, lipid hydroperoxides and lipofuscin significantly decreased compared with the reference group. However, the level of glutathione significantly increased compared with the baseline. Treatment with beta-carotene also resulted in significantly decreased glutathione peroxidase activity compared with the reference group, while the activities of other glutathione-related enzymes and of superoxide dismutase were not significantly changed. However, the activities of glucose-6-phosphate dehydrogenase and catalase, as well as the level of alpha-tocopherol, were significantly higher after treatment compared with the baseline. Despite controversy over the antioxidant properties of beta-carotene in vivo, our findings showed reduced oxidative stress after beta-carotene supplementation in chronic lead poisoning. - Highlights: • Beta-carotene reduces oxidative stress in lead-exposed workers. • Beta-carotene elevates glutathione level in lead-exposed workers. • Beta-carotene administration could be beneficial in lead poisoning

  14. Beta-carotene reduces oxidative stress, improves glutathione metabolism and modifies antioxidant defense systems in lead-exposed workers

    Energy Technology Data Exchange (ETDEWEB)

    Kasperczyk, Sławomir, E-mail: kaslav@mp.pl [Dept. of Biochemistry, School of Medicine with the Division of Dentistry, Medical University of Silesia, ul. Jordana 19, 41-808 Zabrze (Poland); Dobrakowski, Michał [Dept. of Biochemistry, School of Medicine with the Division of Dentistry, Medical University of Silesia, ul. Jordana 19, 41-808 Zabrze (Poland); Kasperczyk, Janusz [Dept. of Environmental Medicine and Epidemiology, School of Medicine with the Division of Dentistry, Medical University of Silesia, ul. Jordana 19, 41-808 Zabrze (Poland); Ostałowska, Alina; Zalejska-Fiolka, Jolanta; Birkner, Ewa [Dept. of Biochemistry, School of Medicine with the Division of Dentistry, Medical University of Silesia, ul. Jordana 19, 41-808 Zabrze (Poland)

    2014-10-01

    The aim of this study was to determine whether beta-carotene administration reduces oxidative stress and influences antioxidant, mainly glutathione-related, defense systems in workers chronically exposed to lead. The population consisted of two randomly divided groups of healthy male volunteers exposed to lead. Workers in the first group (reference group) were not administered any antioxidants, while workers in the second group (CAR group) were treated orally with 10 mg of beta-carotene once a day for 12 weeks. Biochemical analysis included measuring markers of lead-exposure and oxidative stress in addition to the levels and activities of selected antioxidants. After treatment, levels of malondialdehyde, lipid hydroperoxides and lipofuscin significantly decreased compared with the reference group. However, the level of glutathione significantly increased compared with the baseline. Treatment with beta-carotene also resulted in significantly decreased glutathione peroxidase activity compared with the reference group, while the activities of other glutathione-related enzymes and of superoxide dismutase were not significantly changed. However, the activities of glucose-6-phosphate dehydrogenase and catalase, as well as the level of alpha-tocopherol, were significantly higher after treatment compared with the baseline. Despite controversy over the antioxidant properties of beta-carotene in vivo, our findings showed reduced oxidative stress after beta-carotene supplementation in chronic lead poisoning. - Highlights: • Beta-carotene reduces oxidative stress in lead-exposed workers. • Beta-carotene elevates glutathione level in lead-exposed workers. • Beta-carotene administration could be beneficial in lead poisoning.

  15. Imaging of the peripheral vascular system

    International Nuclear Information System (INIS)

    Gould, S.A.; Pond, G.D.; Pinsky, S.; Moss, G.S.; Srikantaswamy, S.; Ryo, U.Y.

    1984-01-01

    This book is limited neither to the peripheral vascular system nor to diagnostic imaging techniques. Its 18 chapters cover nonimaging blood-flow techniques (Doppler ultrasound, plethysmography) as well as noninvasive and invasive imaging techniques (ultrasound, computed tomography, radionuclide digital-subtraction angiography, and contrast angiography). These are applied not only to the peripheral vascular system but also to the aorta and vena cava

  16. Image digitizer system for bubble chamber laser

    International Nuclear Information System (INIS)

    Haggerty, H.

    1986-01-01

    An IBM PC-based image digitizer system has been assembled to monitor the laser flash used for holography at the 15 foot bubble chamber. The hardware and the operating software are outlined. For an operational test of the system, an array of LEDs was flashed with a 10 microsecond pulse and the image was grabbed by one of the operating programs and processed

  17. IDAPS (Image Data Automated Processing System) System Description

    Science.gov (United States)

    1988-06-24

    This document describes the physical configuration and components used in the image processing system referred to as IDAPS (Image Data Automated ... Processing System). This system was developed by the Environmental Research Institute of Michigan (ERIM) for Eglin Air Force Base. The system is designed

  18. Advanced millimeter wave imaging systems

    Science.gov (United States)

    Schuchardt, J. M.; Gagliano, J. A.; Stratigos, J. A.; Webb, L. L.; Newton, J. M.

    1980-01-01

    Unique techniques are being utilized to develop self-contained imaging radiometers operating at single and multiple frequencies near 35, 95 and 183 GHz. These techniques include medium to large antennas for high spatial resolution, lowloss open structures for RF confinemnt and calibration, wide bandwidths for good sensitivity plus total automation of the unit operation and data collection. Applications include: detection of severe storms, imaging of motor vehicles, and the remote sensing of changes in material properties.

  19. Automated imaging system for single molecules

    Science.gov (United States)

    Schwartz, David Charles; Runnheim, Rodney; Forrest, Daniel

    2012-09-18

    There is provided a high throughput automated single molecule image collection and processing system that requires minimal initial user input. The unique features embodied in the present disclosure allow automated collection and initial processing of optical images of single molecules and their assemblies. Correct focus may be automatically maintained while images are collected. Uneven illumination in fluorescence microscopy is accounted for, and an overall robust imaging operation is provided yielding individual images prepared for further processing in external systems. Embodiments described herein are useful in studies of any macromolecules such as DNA, RNA, peptides and proteins. The automated image collection and processing system and method of same may be implemented and deployed over a computer network, and may be ergonomically optimized to facilitate user interaction.

  20. Development of a THz spectroscopic imaging system

    International Nuclear Information System (INIS)

    Usami, M; Iwamoto, T; Fukasawa, R; Tani, M; Watanabe, M; Sakai, K

    2002-01-01

    We have developed a real-time THz imaging system based on the two-dimensional (2D) electro-optic (EO) sampling technique. Employing the 2D EO-sampling technique, we can obtain THz images using a CCD camera at a video rate of up to 30 frames per second. A spatial resolution of 1.4 mm was achieved. This resolution was reasonably close to the theoretical limit determined by diffraction. We observed not only static objects but also moving ones. To acquire spectroscopic information, time-domain images were collected. By processing these images on a computer, we can obtain spectroscopic images. Spectroscopy for silicon wafers was demonstrated

  1. Clinical software for MR imaging system, 4

    International Nuclear Information System (INIS)

    Shimizu, Koji; Kasai, Akira; Okamura, Shoichi

    1992-01-01

    Magnetic resonance imaging continues to elicit new application software through the recent technological advances of MR equipment. This paper describes several applications of our newly developed clinical software. The fast SE sequence (RISE) has proved to reduce routine examination time and to improve image quality, and ultra-fast FE sequence (SMASH) was found to extend the diagnostic capabilities in the field of cardiac study. Diffusion/perfusion imaging achieved in our MR system showed significant promise for providing novel information regarding tissue characterization. Furthermore, Image quality and practicalities of MR angiography have been improved by advanced imaging sequences and sophisticated post-processing software. (author)

  2. Image quality of digital mammography images produced using wet and dry laser imaging systems

    International Nuclear Information System (INIS)

    Al Khalifah, K.; Brindhaban, A.; AlArfaj, R.; Jassim, O.

    2006-01-01

    Introduction: A study was carried out to compare the quality of digital mammographic images printed or processed by a wet laser imaging system and a dedicated mammographic dry laser imaging system. Material and methods: Digital images of a tissue equivalent breast phantom were obtained using a GE Senographe 2000D digital mammography system and different target/filter combinations of the X-ray tube. These images were printed on films using the Fuji FL-IM D wet laser imaging system and the Kodak DryView 8600 dry laser imaging system. The quality of images was assessed in terms of detectability of microcalcifications and simulated tumour masses by five radiologists. In addition, the contrast index and speed index of the two systems were measured using the step wedge in the phantom. The unpaired, unequal variance t-test was used to test any statistically significant differences. Results: There were no significant (p < 0.05) differences between the images printed using the two systems in terms of microcalcification and tumour mass detectability. The wet system resulted in slightly higher contrast index while the dry system showed significantly higher speed index. Conclusion: Both wet and dry laser imaging systems can produce mammography images of good quality on which 0.2 mm microcalcifications and 2 mm tumour masses can be detected. Dry systems are preferable due to the absence of wet chemical processing and solid or liquid chemical waste. The wet laser imaging systems, however, still represent a useful alternative to dry laser imaging systems for mammography studies

  3. Operating program for an automatic alpha-beta counting system-FAG

    International Nuclear Information System (INIS)

    German, U.; Levinson, L.; Shemesh, Y.; Peled, O.; Weistein, M.

    1996-01-01

    An alpha and beta counting system - FAG, for planchette samples is operated at the Health Physics department's laboratory of the NRCN. The system consists of a proportional detector of 8'' diameter operated in coincidence with a guard detector, an automatic sample changer (FAG-FHT770E) and electronics (FAG- FHT1100 digital counter and controller). The original operation mode of the system was based on manual tasks handled by the FHT1100 electronics. Pin option for a basic computer keyboard operation was available too. A computer with appropriate 110 card was connected to the system and a new operating program was developed which enables full automatic control of the various components. The program includes activity calculations and statistical checks as well as data management. The program which was developed enables computer control of all components of the system, based on bi-directional communication. The computer software controls the FHT1100 electronics using the R5232 protocol and the sample changer by an additional 110 card Contec Inodel PIO-48W(PC). The computer controls the whole operation of the system: change of samples, high voltage change, start, stop etc. It handles in the appropriate order the different commands and operates the electronic and mechanic components accordingly (authors)

  4. Operating program for an automatic alpha-beta counting system-FAG

    Energy Technology Data Exchange (ETDEWEB)

    German, U; Levinson, L; Shemesh, Y; Peled, O; Weistein, M [Israel Atomic Energy Commission, Beersheba (Israel). Nuclear Research Center-Negev

    1996-12-01

    An alpha and beta counting system - FAG, for planchette samples is operated at the Health Physics department`s laboratory of the NRCN. The system consists of a proportional detector of 8`` diameter operated in coincidence with a guard detector, an automatic sample changer (FAG-FHT770E) and electronics (FAG- FHT1100 digital counter and controller). The original operation mode of the system was based on manual tasks handled by the FHT1100 electronics. Pin option for a basic computer keyboard operation was available too. A computer with appropriate 110 card was connected to the system and a new operating program was developed which enables full automatic control of the various components. The program includes activity calculations and statistical checks as well as data management. The program which was developed enables computer control of all components of the system, based on bi-directional communication. The computer software controls the FHT1100 electronics using the R5232 protocol and the sample changer by an additional 110 card Contec Inodel PIO-48W(PC). The computer controls the whole operation of the system: change of samples, high voltage change, start, stop etc. It handles in the appropriate order the different commands and operates the electronic and mechanic components accordingly (authors).

  5. Efficacy of pre-scan beta-blockade and impact of heart rate on image quality in patients undergoing coronary multidetector computed tomography angiography

    International Nuclear Information System (INIS)

    Shapiro, Michael D.; Pena, Antonio J.; Nichols, John H.; Worrell, Stewart; Bamberg, Fabian; Dannemann, Nina; Abbara, Suhny; Cury, Ricardo C.; Brady, Thomas J.; Hoffmann, Udo

    2008-01-01

    Objective: While beta-blockers are routinely administered to patients prior to coronary computed tomography angiography (CTA), their effectiveness is unknown. We therefore assessed the efficacy of beta-blockade with regards to heart rate (HR) control and image quality in an unselected patient cohort. Methods: We studied 150 consecutive patients (104 men/46 female; mean age, 56 ± 13 years) referred for coronary CTA. Intravenous metoprolol (5-20 mg) was administered to patients with a HR >65 beats per minute (bpm). The goal HR was defined as an average HR <65 bpm without a single measurement above 68 bpm. Results: Overall, 45% (68/150) of patients met the HR criteria for beta-blocker administration of which 76% (52/68) received metoprolol (mean dose 12 ± 10 mg). Of the 52 patients who received beta-blocker versus the 98 who did not, 18 (35%) versus 62 (64%) patients achieved the goal HR, respectively. All patients who achieved the target HR had an evaluable CTA while five patients who did not achieve the target HR had at least one non-evaluable coronary artery due to motion artifact. There was also a significant reduction in any motion artifact among those who achieved the goal HR as compared to those who did not (p = 0.001). Logistic regression revealed an increase in the odds of stair step artifact of 11.6% (95% CI: 2.4% decrease, 27.5% increase) per 1 bpm increase in the standard deviation of scan HR. Conclusion: Overall, efficacy of beta-blocker administration to reach target HR is limited. Improvements in CT scanner temporal resolution are mandatory to achieve consistently high image quality independent of HR and beta-blocker administration

  6. Efficacy of pre-scan beta-blockade and impact of heart rate on image quality in patients undergoing coronary multidetector computed tomography angiography

    Energy Technology Data Exchange (ETDEWEB)

    Shapiro, Michael D. [Cardiac MR PET CT Program, Massachusetts General Hospital and Harvard Medical School, Boston MA (United States); Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston MA (United States); Pena, Antonio J.; Nichols, John H. [Cardiac MR PET CT Program, Massachusetts General Hospital and Harvard Medical School, Boston MA (United States); Worrell, Stewart [Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston MA (United States); Bamberg, Fabian [Cardiac MR PET CT Program, Massachusetts General Hospital and Harvard Medical School, Boston MA (United States); Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston MA (United States); Dannemann, Nina [Cardiac MR PET CT Program, Massachusetts General Hospital and Harvard Medical School, Boston MA (United States); Abbara, Suhny; Cury, Ricardo C.; Brady, Thomas J. [Cardiac MR PET CT Program, Massachusetts General Hospital and Harvard Medical School, Boston MA (United States); Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston MA (United States); Hoffmann, Udo [Cardiac MR PET CT Program, Massachusetts General Hospital and Harvard Medical School, Boston MA (United States); Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston MA (United States)], E-mail: uhoffmann@partners.org

    2008-04-15

    Objective: While beta-blockers are routinely administered to patients prior to coronary computed tomography angiography (CTA), their effectiveness is unknown. We therefore assessed the efficacy of beta-blockade with regards to heart rate (HR) control and image quality in an unselected patient cohort. Methods: We studied 150 consecutive patients (104 men/46 female; mean age, 56 {+-} 13 years) referred for coronary CTA. Intravenous metoprolol (5-20 mg) was administered to patients with a HR >65 beats per minute (bpm). The goal HR was defined as an average HR <65 bpm without a single measurement above 68 bpm. Results: Overall, 45% (68/150) of patients met the HR criteria for beta-blocker administration of which 76% (52/68) received metoprolol (mean dose 12 {+-} 10 mg). Of the 52 patients who received beta-blocker versus the 98 who did not, 18 (35%) versus 62 (64%) patients achieved the goal HR, respectively. All patients who achieved the target HR had an evaluable CTA while five patients who did not achieve the target HR had at least one non-evaluable coronary artery due to motion artifact. There was also a significant reduction in any motion artifact among those who achieved the goal HR as compared to those who did not (p = 0.001). Logistic regression revealed an increase in the odds of stair step artifact of 11.6% (95% CI: 2.4% decrease, 27.5% increase) per 1 bpm increase in the standard deviation of scan HR. Conclusion: Overall, efficacy of beta-blocker administration to reach target HR is limited. Improvements in CT scanner temporal resolution are mandatory to achieve consistently high image quality independent of HR and beta-blocker administration.

  7. IFN-beta inhibits T cell activation capacity of central nervous system APCs

    DEFF Research Database (Denmark)

    Teige, Ingrid; Liu, Yawei; Issazadeh-Navikas, Shohreh

    2006-01-01

    We have previously investigated the physiological effects of IFN-beta on chronic CNS inflammation and shown that IFN-beta(-/-) mice develop a more severe experimental autoimmune encephalomyelitis than their IFN-beta(+/-) littermates. This result was shown to be associated with a higher activation...... state of the glial cells and a higher T cell cytokine production in the CNS. Because this state suggested a down-regulatory effect of IFN-beta on CNS-specific APCs, these results were investigated further. We report that IFN-beta pretreatment of astrocytes and microglia (glial cells) indeed down......-modulate their capacity to activate autoreactive Th1 cells. First, we investigated the intrinsic ability of glial cells as APCs and report that glial cells prevent autoreactive Th1 cells expansion while maintaining Ag-specific T cell effector functions. However, when the glial cells are treated with IFN-beta before...

  8. High sensitivity optical molecular imaging system

    Science.gov (United States)

    An, Yu; Yuan, Gao; Huang, Chao; Jiang, Shixin; Zhang, Peng; Wang, Kun; Tian, Jie

    2018-02-01

    Optical Molecular Imaging (OMI) has the advantages of high sensitivity, low cost and ease of use. By labeling the regions of interest with fluorescent or bioluminescence probes, OMI can noninvasively obtain the distribution of the probes in vivo, which play the key role in cancer research, pharmacokinetics and other biological studies. In preclinical and clinical application, the image depth, resolution and sensitivity are the key factors for researchers to use OMI. In this paper, we report a high sensitivity optical molecular imaging system developed by our group, which can improve the imaging depth in phantom to nearly 5cm, high resolution at 2cm depth, and high image sensitivity. To validate the performance of the system, special designed phantom experiments and weak light detection experiment were implemented. The results shows that cooperated with high performance electron-multiplying charge coupled device (EMCCD) camera, precision design of light path system and high efficient image techniques, our OMI system can simultaneously collect the light-emitted signals generated by fluorescence molecular imaging, bioluminescence imaging, Cherenkov luminance and other optical imaging modality, and observe the internal distribution of light-emitting agents fast and accurately.

  9. Development of gamma-photon/Cerenkov-light hybrid system for simultaneous imaging of I-131 radionuclide

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, Seiichi; Suzuki, Mayumi; Kato, Katsuhiko [Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine (Japan); Watabe, Tadashi; Ikeda, Hayato; Kanai, Yasukazu [Department of Molecular Imaging in Medicine, Osaka University Graduate School of Medicine (Japan); Ogata, Yoshimune [Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine (Japan); Hatazawa, Jun [Department of Molecular Imaging in Medicine, Osaka University Graduate School of Medicine (Japan)

    2016-09-11

    Although iodine 131 (I-131) is used for radionuclide therapy, high resolution images are difficult to obtain with conventional gamma cameras because of the high energy of I-131 gamma photons (364 keV). Cerenkov-light imaging is a possible method for beta emitting radionuclides, and I-131 (606 MeV maximum beta energy) is a candidate to obtain high resolution images. We developed a high energy gamma camera system for I-131 radionuclide and combined it with a Cerenkov-light imaging system to form a gamma-photon/Cerenkov-light hybrid imaging system to compare the simultaneously measured images of these two modalities. The high energy gamma imaging detector used 0.85-mm×0.85-mm×10-mm thick GAGG scintillator pixels arranged in a 44×44 matrix with a 0.1-mm thick reflector and optical coupled to a Hamamatsu 2 in. square position sensitive photomultiplier tube (PSPMT: H12700 MOD). The gamma imaging detector was encased in a 2 cm thick tungsten shield, and a pinhole collimator was mounted on its top to form a gamma camera system. The Cerenkov-light imaging system was made of a high sensitivity cooled CCD camera. The Cerenkov-light imaging system was combined with the gamma camera using optical mirrors to image the same area of the subject. With this configuration, we simultaneously imaged the gamma photons and the Cerenkov-light from I-131 in the subjects. The spatial resolution and sensitivity of the gamma camera system for I-131 were respectively ~3 mm FWHM and ~10 cps/MBq for the high sensitivity collimator at 10 cm from the collimator surface. The spatial resolution of the Cerenkov-light imaging system was 0.64 mm FWHM at 10 cm from the system surface. Thyroid phantom and rat images were successfully obtained with the developed gamma-photon/Cerenkov-light hybrid imaging system, allowing direct comparison of these two modalities. Our developed gamma-photon/Cerenkov-light hybrid imaging system will be useful to evaluate the advantages and disadvantages of these two

  10. Lossy image compression for digital medical imaging systems

    Science.gov (United States)

    Wilhelm, Paul S.; Haynor, David R.; Kim, Yongmin; Nelson, Alan C.; Riskin, Eve A.

    1990-07-01

    Image compression at rates of 10:1 or greater could make PACS much more responsive and economically attractive. This paper describes a protocol for subjective and objective evaluation of the fidelity of compressed/decompressed images to the originals and presents the results ofits application to four representative and promising compression methods. The methods examined are predictive pruned tree-structured vector quantization, fractal compression, the discrete cosine transform with equal weighting of block bit allocation, and the discrete cosine transform with human visual system weighting of block bit allocation. Vector quantization is theoretically capable of producing the best compressed images, but has proven to be difficult to effectively implement. It has the advantage that it can reconstruct images quickly through a simple lookup table. Disadvantages are that codebook training is required, the method is computationally intensive, and achieving the optimum performance would require prohibitively long vector dimensions. Fractal compression is a relatively new compression technique, but has produced satisfactory results while being computationally simple. It is fast at both image compression and image reconstruction. Discrete cosine iransform techniques reproduce images well, but have traditionally been hampered by the need for intensive computing to compress and decompress images. A protocol was developed for side-by-side observer comparison of reconstructed images with originals. Three 1024 X 1024 CR (Computed Radiography) images and two 512 X 512 X-ray CT images were viewed at six bit rates (0.2, 0.4, 0.6, 0.9, 1.2, and 1.5 bpp for CR, and 1.0, 1.3, 1.6, 1.9, 2.2, 2.5 bpp for X-ray CT) by nine radiologists at the University of Washington Medical Center. The CR images were viewed on a Pixar II Megascan (2560 X 2048) monitor and the CT images on a Sony (1280 X 1024) monitor. The radiologists' subjective evaluations of image fidelity were compared to

  11. A gamma cammera image processing system

    International Nuclear Information System (INIS)

    Chen Weihua; Mei Jufang; Jiang Wenchuan; Guo Zhenxiang

    1987-01-01

    A microcomputer based gamma camera image processing system has been introduced. Comparing with other systems, the feature of this system is that an inexpensive microcomputer has been combined with specially developed hardware, such as, data acquisition controller, data processor and dynamic display controller, ect. Thus the process of picture processing has been speeded up and the function expense ratio of the system raised

  12. Advanced image display systems in radiology

    International Nuclear Information System (INIS)

    Wendler, T.

    1987-01-01

    Advanced image display systems for the fully digital diagnostic imaging departments of the future will be far more than simple replacements of the traditional film-viewing equipment. The new capabilities of very high resolution and highly dynamic displays offer a userfriendly and problem-oriented way of image interpretation. Advanced harware-, software- and human-machine interaction-concepts have been outlined. A scenario for a future way of handling and displaying images, reflecting a new image viewing paradigm in radiology is sketched which has been realized in an experimental image workstation model in the laboratory which, despite its technical complexity, offers a consistent strategy for fast and convenient interaction with image objects. The perspective of knowledge based techniques for workstation control software with object-oriented programming environments and user- and task-adaptive behavior leads to more advanced display properties and a new quality of userfriendliness. 2 refs.; 5 figs

  13. Studies of metal-biomolecule systems in liquids with beta-detected NMR

    CERN Document Server

    Walczak, Michal

    2017-01-01

    My internship took place within a small research team funded via the European Research Council (ERC Starting Grant: Beta-Drop NMR) at ISOLDE. It was devoted to laser spin-polarization and beta-detected NMR techniques and their future applications in chemistry and biology. I was involved in the design and tests of the beta-NMR spectrometer which will be used in the upcoming experiments. In this way I have been exposed to many topics in physics (atomic and nuclear physics), experimental techniques (vacuum technology, lasers, beta detectors, electronics, DAQ software), as well as chemistry and biology (NMR on metal ions, metal ion binding to biomolecules, quantum chemistry calculations).

  14. MONSOON Image Acquisition System | CTIO

    Science.gov (United States)

    Staff CTIO History CTIO Directors Historic Highlights Site Description Contact Us Astronomers Observing Contact Acknowledgments TS4 History ISPI ISPI Exposure Time Calculator OSIRIS Spartan Optical Imagers single detector to very large focal planes made from arrays of detectors. The basic hierarchy of a

  15. The slow control system of the GERDA double beta decay experiment at Gran Sasso

    International Nuclear Information System (INIS)

    Brugnera, R; Garfagnini, A; Gigante, G; Hemmer, S; Zinato, D; Costa, F; Lippi, I; Michelotto, M; Ur, C

    2012-01-01

    GERDA is an experiment designed and built to study double beta decays of 76 Ge. It is currently in operation at the Gran Sasso underground laboratories (LNGS). A custom slow control system has been designed to monitor and control all the critical parameters for the proper functioning of the experiment. The main sub-components of the experiment (Cryostat, Clean Room, Water Tank, electronic crates and temperatures, High Voltage Systems, Radon Monitor and Source Insertion System) are constantly monitored by several distributed clients which write acquired data to a relational database (PostgreSQL). The latter allows to maintain a history of the whole experiment and, performing correlation between different and independent components, is useful to debug possible system malfunctions. The system is complemented by a Web server, a lightweight and efficient interface to the user on shifts and to the on-call experts, and by a dedicated Alarm dispatcher which distributes the errors generated by the components to the users allowing to react in short time. The whole project has been built around open source and custom software.

  16. Devices for Evaluating Imaging Systems. Chapter 15

    Energy Technology Data Exchange (ETDEWEB)

    Demirkaya, O.; Al-Mazrou, R. [Department of Biomedical Physics, King Faisal Specialist Hospital and Research Centre, Riyadh (Saudi Arabia)

    2014-12-15

    A quality management system (QMS) has three main components: (a) Quality assurance (QA); (b) Quality improvement; (c) Quality control (QC). The aim of a QMS is to ensure that the deliverables meet the requirements set forth by the users. The deliverables can be, in general, all the services provided in a nuclear medicine department, and the diagnostic imaging services in particular. In this section, the primary focus is the diagnostic imaging equipment and images produced by them.

  17. Imaging of dopaminergic system in movement disorders

    International Nuclear Information System (INIS)

    Kim, Yu Kyeong; Kim, Sang Eun

    2007-01-01

    Parkinson's disease is a common neurodegenerative disorder that is mainly caused by dopaminergic neuron loss in the substantia nigra. Several radiopharmaceutics have been developed to evaluated the integrity of dopaminergic neuronal system. In vivo PET and SPECT imaging of presynaptic dopamine imaging are already applied to Parkinson's disease and other parkinsonism, and can demonstrate the dopaminergic dysfunction. This review summarized the use of the presynaptic dopaminergic imaging in PD as biomarkers in evaluation of disease progression as well as in diagnosis of PD

  18. Scanned Image Projection System Employing Intermediate Image Plane

    Science.gov (United States)

    DeJong, Christian Dean (Inventor); Hudman, Joshua M. (Inventor)

    2014-01-01

    In imaging system, a spatial light modulator is configured to produce images by scanning a plurality light beams. A first optical element is configured to cause the plurality of light beams to converge along an optical path defined between the first optical element and the spatial light modulator. A second optical element is disposed between the spatial light modulator and a waveguide. The first optical element and the spatial light modulator are arranged such that an image plane is created between the spatial light modulator and the second optical element. The second optical element is configured to collect the diverging light from the image plane and collimate it. The second optical element then delivers the collimated light to a pupil at an input of the waveguide.

  19. Image processing system for flow pattern measurements

    International Nuclear Information System (INIS)

    Ushijima, Satoru; Miyanaga, Yoichi; Takeda, Hirofumi

    1989-01-01

    This paper describes the development and application of an image processing system for measurements of flow patterns occuring in natural circulation water flows. In this method, the motions of particles scattered in the flow are visualized by a laser light slit and they are recorded on normal video tapes. These image data are converted to digital data with an image processor and then transfered to a large computer. The center points and pathlines of the particle images are numerically analized, and velocity vectors are obtained with these results. In this image processing system, velocity vectors in a vertical plane are measured simultaneously, so that the two dimensional behaviors of various eddies, with low velocity and complicated flow patterns usually observed in natural circulation flows, can be determined almost quantitatively. The measured flow patterns, which were obtained from natural circulation flow experiments, agreed with photographs of the particle movements, and the validity of this measuring system was confirmed in this study. (author)

  20. Fibre laser based broadband THz imaging systems

    DEFF Research Database (Denmark)

    Eichhorn, Finn

    imaging techniques. This thesis exhibits that fiber technology can improve the robustness and the flexibility of terahertz imaging systems both by the use of fiber-optic light sources and the employment of optical fibers as light distribution medium. The main focus is placed on multi-element terahertz...

  1. Image based rendering of iterated function systems

    NARCIS (Netherlands)

    Wijk, van J.J.; Saupe, D.

    2004-01-01

    A fast method to generate fractal imagery is presented. Iterated function systems (IFS) are based on repeatedly copying transformed images. We show that this can be directly translated into standard graphics operations: Each image is generated by texture mapping and blending copies of the previous

  2. Diffusion coefficients of the ternary system (2-hydroxypropyl-{beta}-cyclodextrin + caffeine + water) at T = 298.15 K

    Energy Technology Data Exchange (ETDEWEB)

    Ribeiro, Ana C.F. [Department of Chemistry, University of Coimbra, 3004-535 Coimbra (Portugal)], E-mail: anacfrib@ci.uc.pt; Santos, Cecilia I.A.V. [Departamento de Quimica Fisica, Facultad de Farmacia, Universidad de Alcala, 28871 Alcala de Henares, Madrid (Spain)], E-mail: cecilia.alves@uah.es; Lobo, Victor M.M. [Department of Chemistry, University of Coimbra, 3004-535 Coimbra (Portugal)], E-mail: vlobo@ci.uc.pt; Cabral, Ana M.T.D.P.V. [Faculty of Pharmacy, University of Coimbra, 3000-295 Coimbra (Portugal)], E-mail: acabral@ff.uc.pt; Veiga, Francisco J.B. [Faculty of Pharmacy, University of Coimbra, 3000-295 Coimbra (Portugal)], E-mail: fveiga@ci.uc.pt; Esteso, Miguel A. [Departamento de Quimica Fisica, Facultad de Farmacia, Universidad de Alcala, 28871 Alcala de Henares, Madrid (Spain)], E-mail: miguel.esteso@uah.es

    2009-12-15

    Ternary mutual diffusion coefficients measured by Taylor dispersion method (D{sub 11}, D{sub 22}, D{sub 12}, and D{sub 21}) are reported for aqueous solutions of 2-hydroxypropyl-{beta}-cyclodextrin (HP-{beta}-CD) + caffeine at T = 298.15 K at carrier concentrations from (0.000 to 0.010) mol . dm{sup -3}, for each solute, respectively. These diffusion coefficients have been measured having in mind a better understanding of the structure of these systems and thermodynamic behaviour of caffeine and 2-hydroxypropyl-{beta}-cyclodextrin in solution. For example, from these data it will be possible to estimate some parameters, such as the fraction of associated species HP-{beta}-CD (X{sub 1}) and caffeine (X{sub 2}) in this complex, the monomer and dimer fractions, X{sub 2}{sup M} and X{sub 2}{sup D}, respectively, and the limiting diffusion coefficients of the HP-{beta}-CD, D{sub HPBCD}{sup 0}, of the dimers caffeine entities, D{sub D}{sup 0}, and of those complexes (1:1), D{sub complex}{sup 0}.

  3. Sampling system for in vivo ultrasound images

    DEFF Research Database (Denmark)

    Jensen, Jorgen Arendt; Mathorne, Jan

    1991-01-01

    Newly developed algorithms for processing medical ultrasound images use the high frequency sampled transducer signal. This paper describes demands imposed on a sampling system suitable for acquiring such data and gives details about a prototype constructed. It acquires full clinical images...... at a sampling frequency of 20 MHz with a resolution of 12 bits. The prototype can be used for real time image processing. An example of a clinical in vivo image is shown and various aspects of the data acquisition process are discussed....

  4. A standardized method for in vivo mouse pancreas imaging and semiquantitative beta cell mass measurement by dual isotope SPECT

    NARCIS (Netherlands)

    Mathijs, I.; Xavier, C.; Peleman, C.; Caveliers, V.; Brom, M.; Gotthardt, M.; Herrera, P.L.; Lahoutte, T.; Bouwens, L.

    2015-01-01

    PURPOSE: In order to evaluate future beta cell tracers in vivo, we aimed to develop a standardized in vivo method allowing semiquantitative measurement of a prospective beta cell tracer within the pancreas. PROCEDURES: 2-[(123)I]Iodo-L-phenylalanine ([(123)I]IPA) and

  5. New additions to the National Plant Germplasm System's Beta collection: Southern Morocco collection

    Science.gov (United States)

    The USDA Agricultural Research Service’s National Plant Germplasm System’s (NPGS) Beta collection is comprised of 2,541 accessions from 14 species. The largest number of accessions is from Beta vulgaris ssp. vulgaris, (domesticated beet crops – table, leaf (Swiss chard), fodder and, primarily, sugar...

  6. Four-Mirror Freeform Reflective Imaging Systems

    Data.gov (United States)

    National Aeronautics and Space Administration — Central Objectives: The research involves a revelation of the solution space for revolutionary families of four-mirror freeform reflective imaging systems. A...

  7. Fusion of Images from Dissimilar Sensor Systems

    National Research Council Canada - National Science Library

    Chow, Khin

    2004-01-01

    Different sensors exploit different regions of the electromagnetic spectrum; therefore a multi-sensor image fusion system can take full advantage of the complementary capabilities of individual sensors in the suit...

  8. Shimadzu magnetic resonance imaging system, SMT-50

    International Nuclear Information System (INIS)

    Oikawa, Shiro; Nishida, Takayuki; Fujio, Yasuo

    1986-01-01

    The magnetic resonance imaging (MRI) system, as a new modality of medical imaging, has already been put to practical applications on many clinical sites, through which a lot of clinical data has been accumulated. It can offer a powerful new probe of internal anatomy of the human body and its functions. Now that the MRI has established its effectiveness in diagnosis, a really practical MRI system which features high efficiency and economical design with high patient throughput is strongly called for. Introduced in this article is a superconductive magnet MRI system, SMT-50, operating at 5000 Gauss. It has realized an excellent diagnostic capability with such functions as multi-slice multi-echo imaging, high sensitive, surface coil technique and so on. High resolution image display (1024 x 1024 pixcel) unit and separate console system (viewing console and scanning console) will assist high patient throughput. The outline of the SMT-50 and its clinical data are reported here. (author)

  9. Myocardial imaging in acute myocardial infarction using. beta. -methyl-p-( sup 123 I)-iodophenylpentadecanoic acid; Comparison with sup 201 Tl imaging and wall motion

    Energy Technology Data Exchange (ETDEWEB)

    Naruse, Hitoshi; Itano, Midoriko; Kondo, Tomohiro (Hyogo College of Medicine, Nishinomiya (Japan)) (and others)

    1992-01-01

    Myocardial imaging using {beta}-methyl-p-({sup 123}I)-iodophenylpentadecanoic acid (BMIPP) was performed in 11 patients with acute myocardial infarction. The left ventricular images were divided into 12 segments, and myocardial images with BMIPP were compared with coronary angiography (CAG), thallium-201 myocardial scintigraphy (Tl) and wall motion obtained by two-dimensional echocardiography (WM). When the culprit lesion was at the proximal point of the left anterior descending artery (LAD), all segments showed depressed uptake. In 3 cases with single vessel disease of the LAD, inferior wall of the basis showed reduced uptake of BMIPP despite the location of the culprit lesion. In cases with discordant uptake between the two tracers, BMIPP frequently showed more severely depressed uptake than Tl in the subacute phase, although the uptake of BMIPP correlated with that of Tl ({tau}=0.82, p<0.001). In such cases, the discordance was related to the improvement in WM from the acute phase to the convalescent phase. BMIPP uptake correlated with WM in the subacute phase ({tau}=0.50, p<0.001). BMIPP showed more severely depressed uptake while WM showed mild asynergy in most cases in which discordance was found between the BMIPP and WM findings. However, there was no correlation between the change in WM from the acute to subacute phases, or the uptakes of BMIPP and Tl alone. We concluded that the myocardial condition can be evaluated in detail in acute myocardial infarction by comparing the findings of BMIPP with those of Tl and WM. (author).

  10. [Myocardial imaging in acute myocardial infarction using beta-methyl-p-(123I)-iodophenylpentadecanoic acid: comparison with 201Tl imaging and wall motion].

    Science.gov (United States)

    Naruse, H; Itano, M; Kondo, T; Kogame, T; Yamamoto, J; Morita, M; Kawamoto, H; Fukutake, N; Ohyanagi, M; Iwasaki, T

    1992-01-01

    Myocardial imaging using beta-methyl-p-(123I)-iodophenylpentadecanoic acid (BMIPP) was performed in 11 patients with acute myocardial infarction. The left ventricular images were divided into 12 segments, and myocardial imagings with BMIPP were compared with coronary angiography (CAG), thallium-201 myocardial scintigraphy (TL) and wall motion obtained by two-dimensional echocardiography (WM). When the culprit lesion was at the proximal point of the left anterior descending artery (LAD), all segments showed depressed uptake. In 3 cases with single vessel disease of the LAD, inferior wall of the basis showed reduced uptake of BMIPP despite the location of the culprit lesion. In cases with discordant uptake between the two tracers, BMIPP frequently showed more severely depressed uptake than TL in the subacute phase, although the uptake of BMIPP correlated with that of TL (tau = 0.82, p less than 0.001). In such cases, the discordance was related to the improvement in WM from the acute phase to the convalescent phase. BMIPP uptake correlated with WM in the subacute phase (tau = 0.50, p less than 0.001). BMIPP showed more severely depressed uptake while WM showed mild asynergy in most cases in which discordance was found between the BMIPP and WM findings. However, there was no correlation between the change in WM from the acute to subacute phases, or the uptakes of BMIPP and TL alone. We concluded that the myocardial condition can be evaluated in detail in acute myocardial infarction by comparing the findings of BMIPP with those of TL and WM.

  11. Proceedings of the US-Japan workshop and the satellite meeting of ITC-9 on physics of high beta plasma confinement in innovative fusion system

    Energy Technology Data Exchange (ETDEWEB)

    Goto, Seiichi; Yoshimura, Satoru [eds.

    1999-04-01

    The US-Japan Workshop on Physics of High Beta Plasma Confinement in Innovative Fusion System was held jointly with the Satellite Meeting of ITC-9 at National Institute for Fusion Science (NIFS), Toki-city during December 14-15, 1998. This proceedings book includes the papers of the talks given at the workshop. These include: Theoretical analysis on the stability of field reversed configuration (FRC) plasmas; Theory and Modeling of high {beta} plasmas; Recent progressive experiments in high {beta} systems; Formation of high {beta} plasmas using merging phenomenon; Theory and Modeling of a FRC Fusion Reactor. The 15 papers are indexed individually. (J.P.N.)

  12. System for imaging plutonium through heavy shielding

    International Nuclear Information System (INIS)

    Kuckertz, T.H.; Cannon, T.M.; Fenimore, E.E.; Moss, C.E.; Nixon, K.V.

    1984-04-01

    A single pinhole can be used to image strong self-luminescent gamma-ray sources such as plutonium on gamma scintillation (Anger) cameras. However, if the source is weak or heavily shielded, a poor signal to noise ratio can prevent acquisition of the image. An imaging system designed and built at Los Alamos National Laboratory uses a coded aperture to image heavily shielded sources. The paper summarizes the mathematical techniques, based on the Fast Delta Hadamard transform, used to decode raw images. Practical design considerations such as the phase of the uniformly redundant aperture and the encoded image sampling are discussed. The imaging system consists of a custom designed m-sequence coded aperture, a Picker International Corporation gamma scintillation camera, a LeCroy 3500 data acquisition system, and custom imaging software. The paper considers two sources - 1.5 mCi 57 Co unshielded at a distance of 27 m and 220 g of bulk plutonium (11.8% 240 Pu) with 0.3 cm lead, 2.5 cm steel, and 10 cm of dense plastic material at a distance of 77.5 cm. Results show that the location and geometry of a source hidden in a large sealed package can be determined without having to open the package. 6 references, 4 figures

  13. Document Examination: Applications of Image Processing Systems.

    Science.gov (United States)

    Kopainsky, B

    1989-12-01

    Dealing with images is a familiar business for an expert in questioned documents: microscopic, photographic, infrared, and other optical techniques generate images containing the information he or she is looking for. A recent method for extracting most of this information is digital image processing, ranging from the simple contrast and contour enhancement to the advanced restoration of blurred texts. When combined with a sophisticated physical imaging system, an image pricessing system has proven to be a powerful and fast tool for routine non-destructive scanning of suspect documents. This article reviews frequent applications, comprising techniques to increase legibility, two-dimensional spectroscopy (ink discrimination, alterations, erased entries, etc.), comparison techniques (stamps, typescript letters, photo substitution), and densitometry. Computerized comparison of handwriting is not included. Copyright © 1989 Central Police University.

  14. A fractal-based image encryption system

    KAUST Repository

    Abd-El-Hafiz, S. K.

    2014-12-01

    This study introduces a novel image encryption system based on diffusion and confusion processes in which the image information is hidden inside the complex details of fractal images. A simplified encryption technique is, first, presented using a single-fractal image and statistical analysis is performed. A general encryption system utilising multiple fractal images is, then, introduced to improve the performance and increase the encryption key up to hundreds of bits. This improvement is achieved through several parameters: feedback delay, multiplexing and independent horizontal or vertical shifts. The effect of each parameter is studied separately and, then, they are combined to illustrate their influence on the encryption quality. The encryption quality is evaluated using different analysis techniques such as correlation coefficients, differential attack measures, histogram distributions, key sensitivity analysis and the National Institute of Standards and Technology (NIST) statistical test suite. The obtained results show great potential compared to other techniques.

  15. Reliability demonstration of imaging surveillance systems

    International Nuclear Information System (INIS)

    Sheridan, T.F.; Henderson, J.T.; MacDiarmid, P.R.

    1979-01-01

    Security surveillance systems which employ closed circuit television are being deployed with increasing frequency for the protection of property and other valuable assets. A need exists to demonstrate the reliability of such systems before their installation to assure that the deployed systems will operate when needed with only the scheduled amount of maintenance and support costs. An approach to the reliability demonstration of imaging surveillance systems which employ closed circuit television is described. Failure definitions based on industry television standards and imaging alarm assessment criteria for surveillance systems are discussed. Test methods which allow 24 hour a day operation without the need for numerous test scenarios, test personnel and elaborate test facilities are presented. Existing reliability demonstration standards are shown to apply which obviate the need for elaborate statistical tests. The demonstration methods employed are shown to have applications in other types of imaging surveillance systems besides closed circuit television

  16. Breast imaging and reporting data system (BIRADS): Magnetic resonance imaging

    International Nuclear Information System (INIS)

    Tardivon, Anne A.; Athanasiou, Alexandra; Thibault, Fabienne; El Khoury, Carl

    2007-01-01

    This article reviews the technical aspects and interpretation criteria in breast MR imaging based on the first edition of breast imaging and reporting data system (BIRADS) published by the American College of Radiology (ACR) in 2003. In a second article, practical cases will be proposed for training the readers. The major aims of using this lexicon are: first to use a logical and standardized description of MR lesions, secondly to obtain a structured MR report with a clear final impression (BIRADS assessment categories), and thirdly to help comparison between different clinical studies based on similar breast MRI terminology

  17. Image quality in digital radiographic systems

    Directory of Open Access Journals (Sweden)

    Almeida Solange Maria de

    2003-01-01

    Full Text Available The aim of the present study was to evaluate the image quality of four direct digital radiographic systems. Radiographs were made of the maxillary central incisor and mandibular left molar regions of a dry skull, and an aluminum step-wedge. The X-ray generator operated at 10 mA, 60 and 70 kVp, and images were acquired with 3, 5, 8, 12, 24 and 48 exposure pulses. Six well-trained observers classified the images by means of scores from 1 to 3. Collected data were submitted to nonparametric statistical analysis using Fisher's exact test. Statistical analysis showed significant differences (p<0.01 in image quality with the four systems. Based on the results, it was possible to conclude that: 1 all of the digital systems presented good performance in producing acceptable images for diagnosis, if the exposures of the step-wedge and the maxillary central incisor region were made at 5 pulses, as well as at 8 pulses for the mandibular left molar region, selecting 60 or 70kVp; 2 higher percentages of acceptable images were obtained with the administration of lower radiation doses in CCD-sensors (charge-coupled device; 3 the Storage Phosphor systems produced acceptable images at a large range of exposure settings, that included low, intermediate and high radiation doses.

  18. Image acquisition system for traffic monitoring applications

    Science.gov (United States)

    Auty, Glen; Corke, Peter I.; Dunn, Paul; Jensen, Murray; Macintyre, Ian B.; Mills, Dennis C.; Nguyen, Hao; Simons, Ben

    1995-03-01

    An imaging system for monitoring traffic on multilane highways is discussed. The system, named Safe-T-Cam, is capable of operating 24 hours per day in all but extreme weather conditions and can capture still images of vehicles traveling up to 160 km/hr. Systems operating at different remote locations are networked to allow transmission of images and data to a control center. A remote site facility comprises a vehicle detection and classification module (VCDM), an image acquisition module (IAM) and a license plate recognition module (LPRM). The remote site is connected to the central site by an ISDN communications network. The remote site system is discussed in this paper. The VCDM consists of a video camera, a specialized exposure control unit to maintain consistent image characteristics, and a 'real-time' image processing system that processes 50 images per second. The VCDM can detect and classify vehicles (e.g. cars from trucks). The vehicle class is used to determine what data should be recorded. The VCDM uses a vehicle tracking technique to allow optimum triggering of the high resolution camera of the IAM. The IAM camera combines the features necessary to operate consistently in the harsh environment encountered when imaging a vehicle 'head-on' in both day and night conditions. The image clarity obtained is ideally suited for automatic location and recognition of the vehicle license plate. This paper discusses the camera geometry, sensor characteristics and the image processing methods which permit consistent vehicle segmentation from a cluttered background allowing object oriented pattern recognition to be used for vehicle classification. The image capture of high resolution images and the image characteristics required for the LPRMs automatic reading of vehicle license plates, is also discussed. The results of field tests presented demonstrate that the vision based Safe-T-Cam system, currently installed on open highways, is capable of producing automatic

  19. Hologlyphics: volumetric image synthesis performance system

    Science.gov (United States)

    Funk, Walter

    2008-02-01

    This paper describes a novel volumetric image synthesis system and artistic technique, which generate moving volumetric images in real-time, integrated with music. The system, called the Hologlyphic Funkalizer, is performance based, wherein the images and sound are controlled by a live performer, for the purposes of entertaining a live audience and creating a performance art form unique to volumetric and autostereoscopic images. While currently configured for a specific parallax barrier display, the Hologlyphic Funkalizer's architecture is completely adaptable to various volumetric and autostereoscopic display technologies. Sound is distributed through a multi-channel audio system; currently a quadraphonic speaker setup is implemented. The system controls volumetric image synthesis, production of music and spatial sound via acoustic analysis and human gestural control, using a dedicated control panel, motion sensors, and multiple musical keyboards. Music can be produced by external acoustic instruments, pre-recorded sounds or custom audio synthesis integrated with the volumetric image synthesis. Aspects of the sound can control the evolution of images and visa versa. Sounds can be associated and interact with images, for example voice synthesis can be combined with an animated volumetric mouth, where nuances of generated speech modulate the mouth's expressiveness. Different images can be sent to up to 4 separate displays. The system applies many novel volumetric special effects, and extends several film and video special effects into the volumetric realm. Extensive and various content has been developed and shown to live audiences by a live performer. Real world applications will be explored, with feedback on the human factors.

  20. Visual computing scientific visualization and imaging systems

    CERN Document Server

    2014-01-01

    This volume aims to stimulate discussions on research involving the use of data and digital images as an understanding approach for analysis and visualization of phenomena and experiments. The emphasis is put not only on graphically representing data as a way of increasing its visual analysis, but also on the imaging systems which contribute greatly to the comprehension of real cases. Scientific Visualization and Imaging Systems encompass multidisciplinary areas, with applications in many knowledge fields such as Engineering, Medicine, Material Science, Physics, Geology, Geographic Information Systems, among others. This book is a selection of 13 revised and extended research papers presented in the International Conference on Advanced Computational Engineering and Experimenting -ACE-X conferences 2010 (Paris), 2011 (Algarve), 2012 (Istanbul) and 2013 (Madrid). The examples were particularly chosen from materials research, medical applications, general concepts applied in simulations and image analysis and ot...

  1. Under sodium ultrasonic imaging system for PFBR

    International Nuclear Information System (INIS)

    Patankar, V.H.; Lalwani, S.K.; Agashe, A.A.

    2014-01-01

    Under Sodium UltraSonic Scanner (USUSS) has been developed to detect the growth and protrusion of fuel sub-assemblies of PFBR, submerged in liquid sodium by using the ultrasonic imaging technique during reactor shut-down when liquid sodium is at 180 ℃. The imaging is carried out prior to every Fuel handling operation. Electronics Division, BARC has designed and developed an 8-Channel Ultrasonic Imaging System (UIS) which consists of 4 downward viewing and 4 side viewing ultrasonic transducers alongwith pulser-receiver, signal processing electronics hardware and software. An automated mechanical scanner developed by IGCAR houses sodium immersible transducers to image the fuel sub assemblies. The system has been successfully tested with dummy protruding and grown FSAs, submerged under liquid sodium. Such ultrasonic imaging systems are not available to India from international market. The USUSS developed indigenously has all the features available in similar systems developed by other countries. After every imaging campaign, the mechanical scanner containing ultrasonic transducers is stored in the Argon filled storage-pit. Before every campaign of USUSS, it is necessary to check the healthiness of the sodium immersible and contaminated ultrasonic transducers, as the under-sodium scanner is decontaminated once in five years. For this purpose, a novel Non Contact Ultrasonic Inspection System (NCUIS) has been designed and developed by Electronics Division, BARC to check the functionality of the high-temperature and contaminated transducers of USUSS, using air-coupled ultrasonic technique. (author)

  2. Evaluation of transmitted images by teleradiology system

    International Nuclear Information System (INIS)

    Hoshikawa, Yoshikazu

    1993-01-01

    Teleradiology system is a combination of digital data networks and computer systems, which is the electric transmission of radiographs and/or radiologic images from local to center radiological system. The author evaluated reproducibility of transmitted images using Photophone (Image Data Corporation) as teleradiology system. Proven cases of abdominal free air (38 plain films, 15 CT), pneumothorax (24 plain films, 20 CT) and small bowel obstruction (30 plain films, 8 CT) were transmitted. Findings could be identified on non-magnified plain films in 75.6%, 83.3% and 96.7% respectively and on magnified CT in 100%, 100% and 100%. Transmitted images of 57 cases of abdominal trauma were read for positive findings and diagnosis by three radiologists. Average positive ratio was 47.3% on plain films and 70.9% on CT. Diagnosis was correct in 66.7% on CT. Specificity and sensitivity were 81.9% and 61.6% respectively on plain film and 88.6% and 93.9% on CT. The accuracy of transmitted images appears to be unsatisfactory on this study. It is suggested that the system is useful for consultation of already identified findings on the original images. (author)

  3. Evaluation of transmitted images by teleradiology system

    Energy Technology Data Exchange (ETDEWEB)

    Hoshikawa, Yoshikazu (St. Marianna Univ., Kawasaki (Japan). School of Medicine)

    1993-12-01

    Teleradiology system is a combination of digital data networks and computer systems, which is the electric transmission of radiographs and/or radiologic images from local to center radiological system. The author evaluated reproducibility of transmitted images using Photophone (Image Data Corporation) as teleradiology system. Proven cases of abdominal free air (38 plain films, 15 CT), pneumothorax (24 plain films, 20 CT) and small bowel obstruction (30 plain films, 8 CT) were transmitted. Findings could be identified on non-magnified plain films in 75.6%, 83.3% and 96.7% respectively and on magnified CT in 100%, 100% and 100%. Transmitted images of 57 cases of abdominal trauma were read for positive findings and diagnosis by three radiologists. Average positive ratio was 47.3% on plain films and 70.9% on CT. Diagnosis was correct in 66.7% on CT. Specificity and sensitivity were 81.9% and 61.6% respectively on plain film and 88.6% and 93.9% on CT. The accuracy of transmitted images appears to be unsatisfactory on this study. It is suggested that the system is useful for consultation of already identified findings on the original images. (author).

  4. Imaging system design and image interpolation based on CMOS image sensor

    Science.gov (United States)

    Li, Yu-feng; Liang, Fei; Guo, Rui

    2009-11-01

    An image acquisition system is introduced, which consists of a color CMOS image sensor (OV9620), SRAM (CY62148), CPLD (EPM7128AE) and DSP (TMS320VC5509A). The CPLD implements the logic and timing control to the system. SRAM stores the image data, and DSP controls the image acquisition system through the SCCB (Omni Vision Serial Camera Control Bus). The timing sequence of the CMOS image sensor OV9620 is analyzed. The imaging part and the high speed image data memory unit are designed. The hardware and software design of the image acquisition and processing system is given. CMOS digital cameras use color filter arrays to sample different spectral components, such as red, green, and blue. At the location of each pixel only one color sample is taken, and the other colors must be interpolated from neighboring samples. We use the edge-oriented adaptive interpolation algorithm for the edge pixels and bilinear interpolation algorithm for the non-edge pixels to improve the visual quality of the interpolated images. This method can get high processing speed, decrease the computational complexity, and effectively preserve the image edges.

  5. The National Ignition Facility Neutron Imaging System

    International Nuclear Information System (INIS)

    Wilke, Mark D.; Batha, Steven H.; Bradley, Paul A.; Day, Robert D.; Clark, David D.; Fatherley, Valerie E.; Finch, Joshua P.; Gallegos, Robert A.; Garcia, Felix P.; Grim, Gary P.; Jaramillo, Steven A.; Montoya, Andrew J.; Morgan, George L.; Oertel, John A.; Ortiz, Thomas A.; Payton, Jeremy R.; Pazuchanics, Peter; Schmidt, Derek W.; Valdez, Adelaida C.; Wilde, Carl H.

    2008-01-01

    The National Ignition Facility (NIF) is scheduled to begin deuterium-tritium (DT) shots possibly in the next several years. One of the important diagnostics in understanding capsule behavior and to guide changes in Hohlraum illumination, capsule design, and geometry will be neutron imaging of both the primary 14 MeV neutrons and the lower-energy downscattered neutrons in the 6-13 MeV range. The neutron imaging system (NIS) described here, which we are currently building for use on NIF, uses a precisely aligned set of apertures near the target to form the neutron images on a segmented scintillator. The images are recorded on a gated, intensified charge coupled device. Although the aperture set may be as close as 20 cm to the target, the imaging camera system will be located at a distance of 28 m from the target. At 28 m the camera system is outside the NIF building. Because of the distance and shielding, the imager will be able to obtain images with little background noise. The imager will be capable of imaging downscattered neutrons from failed capsules with yields Y n >10 14 neutrons. The shielding will also permit the NIS to function at neutron yields >10 18 , which is in contrast to most other diagnostics that may not work at high neutron yields. The following describes the current NIF NIS design and compares the predicted performance with the NIF specifications that must be satisfied to generate images that can be interpreted to understand results of a particular shot. The current design, including the aperture, scintillator, camera system, and reconstruction methods, is briefly described. System modeling of the existing Omega NIS and comparison with the Omega data that guided the NIF design based on our Omega results is described. We will show NIS model calculations of the expected NIF images based on component evaluations at Omega. We will also compare the calculated NIF input images with those unfolded from the NIS images generated from our NIS numerical

  6. [Antimicrobial activity of fosfomycin under various conditions against standard strains, beta-lactam resistant strains, and multidrug efflux system mutants].

    Science.gov (United States)

    Mikuniya, Takeshi; Hiraishi, Toru; Maebashi, Kazunori; Ida, Takashi; Takata, Toshihiko; Hikida, Muneo; Yamada, Sakuo; Gotoh, Naomasa; Nishino, Takeshi

    2005-04-01

    The purpose of this study was to evaluate the possible benefit of fosfomycin (FOM) as prophylactic antibiotic in terms of antimicrobial activity and the potential of inducibility of beta-lactamase, compared with cefazolin, cefotiam, cefmetazole, and piperacillin that are commonly used as perioperative agents. The in vitro activity of FOM against aerobic Gram-negative bacteria using Mueller-Hinton agar or nutrient agar supplemented with glucose-6-phosphate (G6P) as tested medium increased within a range from 2 to 256 times the activity in the medium without G6P. However, the susceptibility of Gram-positive bacteria to FOM remained largely unchanged with or without G6P. There was no aerobic- or anaerobic-bacteria which changed susceptibility against beta-lactam antibiotics under various tested medium conditions. FOM demonstrated strong bactericidal activity against Escherichia coli and Pseudomonas aeruginosa in a dose dependent manner, and decreased viable cell counts of Staphylococcus aureus. In the case of P. aeruginosa, transmission electron micrographs study revealed that numerous lysed cells were present 2 hours after treatment with FOM at four times the MIC. First and second generation cephalosporins induced AmpC-type beta-lactamase in a dose dependent manner among beta-lactamase inducible strains of P. aeruginosa and Enterobacter cloacae. On the other hand, inducible activity of FOM on beta-lactamase production was less than 1/25 to 1/65 compared with those of cephalosporins. In addition, FOM maintained strong antimicrobial activity for over then 20 years after marketing, because of the excellent stability against various types of beta-lactamase produced by plasmid-carrying bacteria and clinical isolates. FOM was not extruded by four types of efflux systems, such as MexAB-OprM, MexCD-OprJ, MexXY/ OprM and MexEF-OprN, however beta-lactam antibiotics were substrates of MexAB-OprM and MexCD-OprJ. In conclusion, FOM provides adequate coverage for both aerobic Gram

  7. Design of optically stable image reflector system.

    Science.gov (United States)

    Tsai, Chung-Yu

    2013-08-01

    The design of a partially optically stable (POS) reflector system, in which the exit ray direction and image pose are unchanged as the reflector system rotates about a specific directional vector, was presented in an earlier study by the current group [Appl. Phys. B100, 883-890 (2010)]. The present study further proposes an optically stable image (OSI) reflector system, in which not only is the optical stability property of the POS system retained, but the image position and total ray path length are also fixed. An analytical method is proposed for the design of OSI reflector systems comprising multiple reflectors. The validity of the proposed approach is demonstrated by means of two illustrative examples.

  8. New insights into structure-function relationship of the DHPR beta1a subunit in skeletal muscle excitation-contraction coupling using zebrafish 'relaxed' as an expression system

    International Nuclear Information System (INIS)

    Dayal, A.

    2010-01-01

    The paralyzed zebrafish strain relaxed carries a null mutation for the skeletal muscle dihydropyridine receptor (DHPR) [beta]1a subunit. The lack of [beta]1a not only impedes functional [alpha]1S membrane expression but also precludes the skeletal muscle-specific ultrastructural arrangement of DHPRs into tetrads opposite ryanodine receptor (RyR1), coherent with the absence of skeletal muscle excitation-contraction (EC) coupling. With the plethora of experimental approaches feasible with zebrafish model organism and importantly with the [beta]1-null mutation having a monogenetic inheritance and because of the survival of the relaxed larvae for some days, we were able to establish the zebrafish relaxed as an expression system. Linking in vitro to in vivo observations, a clear differentiation between the major functional roles of [beta] subunits in EC coupling was feasible. The skeletal muscle [beta]1a subunit was able to restore all parameters of EC coupling upon expression in relaxed myotubes and larvae. Expression of the phylogenetically closest isoform to [beta]1a, the cardiac/neuronal [beta]2a subunit or the most distant neuronal [beta]M from the housefly in relaxed myotubes and larvae was likewise able to fully restore [alpha]1S triad targeting and facilitate charge movement. However, efficient tetrad formation and thus intact DHPR-RyR1 coupling was exclusively promoted by the [beta]1a isoform. Consequently, we postulated a model according to which [beta]1a acts as a unique allosteric modifier of [alpha]1S conformation crucial for skeletal muscle EC coupling. Therefore, unique structural elements in [beta]1a must be present which endow it with this exclusive property. Earlier, a unique hydrophobic heptad repeat motif (LVV) in the [beta]1a C-terminus was postulated by others to be essential for skeletal muscle EC coupling. We wanted to address the question if the proposed [beta]1a heptad repeat motif could be an active element of the DHPR-RyR1 signal transduction

  9. Data on a new beta titanium alloy system reinforced with superlattice intermetallic precipitates

    Directory of Open Access Journals (Sweden)

    Alexander J. Knowles

    2018-04-01

    Full Text Available The data presented in this article are related to the research article entitled “a new beta titanium alloy system reinforced with superlattice intermetallic precipitates” (Knowles et al., 2018 [1]. This includes data from the as-cast alloy obtained using scanning electron microscopy (SEM and x-ray diffraction (XRD as well as SEM data in the solution heat treated condition. Transmission electron microscopy (TEM selected area diffraction patterns (SADPs are included from the alloy in the solution heat treated condition, as well as the aged condition that contained < 100 nm B2 TiFe precipitates [1], the latter of which was found to exhibit double diffraction owing to the precipitate and matrix channels being of a similar width to the foil thickness (Williams and Carter, 2009 [2]. Further details are provided on the macroscopic compression testing of small scale cylinders. Of the micropillar deformation experiment performed in [1], SEM micrographs of focused ion beam (FIB prepared 2 µm micropillars are presented alongside those obtained at the end of the in-situ SEM deformation as well as videos of the in-situ deformation. Further, a table is included that lists the Schmidt factors of all the possible slip systems given the crystal orientations and loading axis of the deformed micropillars in the solution heat treated and aged conditions.

  10. Spatial genetic structure in Beta vulgaris subsp. maritima and Beta macrocarpa reveals the effect of contrasting mating system, influence of marine currents, and footprints of postglacial recolonization routes.

    Science.gov (United States)

    Leys, Marie; Petit, Eric J; El-Bahloul, Yasmina; Liso, Camille; Fournet, Sylvain; Arnaud, Jean-François

    2014-05-01

    Understanding the factors that contribute to population genetic divergence across a species' range is a long-standing goal in evolutionary biology and ecological genetics. We examined the relative importance of historical and ecological features in shaping the present-day spatial patterns of genetic structure in two related plant species, Beta vulgaris subsp. maritima and Beta macrocarpa. Using nuclear and mitochondrial markers, we surveyed 93 populations from Brittany (France) to Morocco - the southern limit of their species' range distribution. Whereas B. macrocarpa showed a genotypic structure and a high level of genetic differentiation indicative of selfing, the population genetic structure of B. vulgaris subsp. maritima was consistent with an outcrossing mating system. We further showed (1) a strong geographic clustering in coastal B. vulgaris subsp. maritima populations that highlighted the influence of marine currents in shaping different lineages and (2) a peculiar genetic structure of inland B. vulgaris subsp. maritima populations that could indicate the admixture of distinct evolutionary lineages and recent expansions associated with anthropogenic disturbances. Spatial patterns of nuclear diversity and differentiation also supported a stepwise recolonization of Europe from Atlantic-Mediterranean refugia after the last glacial period, with leading-edge expansions. However, cytoplasmic diversity was not impacted by postglacial recolonization: stochastic long-distance seed dispersal mediated by major oceanic currents may mitigate the common patterns of reduced cytoplasmic diversity observed for edge populations. Overall, the patterns we documented here challenge the general view of reduced genetic diversity at the edge of a species' range distribution and provide clues for understanding how life-history and major geographic features interact to shape the distribution of genetic diversity.

  11. Imaging of primary central nervous system lymphoma

    Energy Technology Data Exchange (ETDEWEB)

    Tang, Y.Z., E-mail: yenzhitang@doctors.net.uk [Royal Free Hospital, London (United Kingdom); Booth, T.C.; Bhogal, P.; Malhotra, A.; Wilhelm, T. [Royal Free Hospital, London (United Kingdom)

    2011-08-15

    Primary central nervous system lymphoma (PCNSL) comprises 5% of all primary brain tumours. PCNSL demonstrates a variety of well-documented imaging findings, which can vary depending on immune status and histological type. Imaging features of PCNSL may overlap with other tumours and infection making definitive diagnosis challenging. In addition, several rare variants of PCNSL have been described, each with their own imaging characteristics. Advanced imaging techniques including 2-[{sup 18}F]-fluoro-2-deoxy-D-glucose ({sup 18}FDG) and {sup 11}C positron-emission tomography (PET), {sup 201}Tl single-photon emission computed tomography (SPECT), {sup 1}H-magnetic resonance spectroscopy (MRS), and MR perfusion, have been used to aid differentiation of PCNSL from other tumours. Ultimately, no imaging method can definitively diagnose PCNSL, and histology is required.

  12. Expert System for ASIC Imaging

    Science.gov (United States)

    Gupta, Shri N.; Arshak, Khalil I.; McDonnell, Pearse; Boyce, Conor; Duggan, Andrew

    1989-07-01

    With the developments in the techniques of artificial intelligence over the last few years, development of advisory, scheduling and similar class of problems has become very convenient using tools such as PROLOG. In this paper an expert system has been described which helps lithographers and process engineers in several ways. The methodology used is to model each work station according to its input, output and control parameters, combine these work stations in a logical sequence based on past experience and work out process schedule for a job. In addition, all the requirements vis-a-vis a particular job parameters are converted into decision rules. One example is the exposure time, develop time for a wafer with different feature sizes would be different. This expert system has been written in Turbo Prolog. By building up a large number of rules, one can tune the program to any facility and use it for as diverse applications as advisory help, trouble shooting etc. Leitner (1) has described an advisory expert system that is being used at National Semiconductor. This system is quite different from the one being reported in the present paper. The approach is quite different for one. There is stress on job flow and process for another.

  13. Architecture Of High Speed Image Processing System

    Science.gov (United States)

    Konishi, Toshio; Hayashi, Hiroshi; Ohki, Tohru

    1988-01-01

    One of architectures for a high speed image processing system which corresponds to a new algorithm for a shape understanding is proposed. And the hardware system which is based on the archtecture was developed. Consideration points of the architecture are mainly that using processors should match with the processing sequence of the target image and that the developed system should be used practically in an industry. As the result, it was possible to perform each processing at a speed of 80 nano-seconds a pixel.

  14. Highly Protable Airborne Multispectral Imaging System

    Science.gov (United States)

    Lehnemann, Robert; Mcnamee, Todd

    2001-01-01

    A portable instrumentation system is described that includes and airborne and a ground-based subsytem. It can acquire multispectral image data over swaths of terrain ranging in width from about 1.5 to 1 km. The system was developed especially for use in coastal environments and is well suited for performing remote sensing and general environmental monitoring. It includes a small,munpilotaed, remotely controlled airplance that carries a forward-looking camera for navigation, three downward-looking monochrome video cameras for imaging terrain in three spectral bands, a video transmitter, and a Global Positioning System (GPS) reciever.

  15. MIDAS - ESO's new image processing system

    Science.gov (United States)

    Banse, K.; Crane, P.; Grosbol, P.; Middleburg, F.; Ounnas, C.; Ponz, D.; Waldthausen, H.

    1983-03-01

    The Munich Image Data Analysis System (MIDAS) is an image processing system whose heart is a pair of VAX 11/780 computers linked together via DECnet. One of these computers, VAX-A, is equipped with 3.5 Mbytes of memory, 1.2 Gbytes of disk storage, and two tape drives with 800/1600 bpi density. The other computer, VAX-B, has 4.0 Mbytes of memory, 688 Mbytes of disk storage, and one tape drive with 1600/6250 bpi density. MIDAS is a command-driven system geared toward the interactive user. The type and number of parameters in a command depends on the unique parameter invoked. MIDAS is a highly modular system that provides building blocks for the undertaking of more sophisticated applications. Presently, 175 commands are available. These include the modification of the color-lookup table interactively, to enhance various image features, and the interactive extraction of subimages.

  16. {beta}-TCP porous pellets as an orthopaedic drug delivery system: ibuprofen/carrier physicochemical interactions

    Energy Technology Data Exchange (ETDEWEB)

    Baradari, Hiba; Damia, Chantal; Dutreih-Colas, Maggy; Champion, Eric; Chulia, Dominique; Viana, Marylene, E-mail: hiva.baradari@etu.unilim.fr [SPCTS-Centre Europeen de la Ceramique, 12 Rue Atlantis, 87068 Limoges CEDEX (France)

    2011-10-15

    Calcium phosphate bone substitute materials can be loaded with active substances for in situ, targeted drug administration. In this study, porous {beta}-TCP pellets were investigated as an anti-inflammatory drug carrier. Porous {beta}-TCP pellets were impregnated with an ethanolic solution of ibuprofen. The effects of contact time and concentration of ibuprofen solution on drug adsorption were studied. The ibuprofen adsorption equilibrium time was found to be one hour. The adsorption isotherms fitted to the Freundlich model, suggesting that the interaction between ibuprofen and {beta}-TCP is weak. The physicochemical characterizations of loaded pellets confirmed that the reversible physisorption of ibuprofen on {beta}-TCP pellets is due to Van der Waals forces, and this property was associated with the 100% ibuprofen release.

  17. High speed imaging system for nuclear diagnostics

    International Nuclear Information System (INIS)

    Eyer, H.H.

    1976-01-01

    A high speed imaging system based on state-of-the-art photosensor arrays has been designed for use in nuclear diagnostics. The system is comprised of a front-end rapid-scan solid-state camera, a high speed digitizer, and a PCM line driver in a downhole package and a memory buffer system in a uphole trailer. The downhole camera takes a ''snapshot'' of a nuclear device created flux stream, digitizes the image and transmits it to the uphole memory system before being destroyed. The memory system performs two functions: it retains the data for local display and processing by a microprocessor, and it buffers the data for retransmission at slower rates to the LLL computational facility (NADS). The impetus for such a system as well as its operation are discussed. Also discussed are new systems under development which incorporate higher data rates and more resolution

  18. High speed imaging system for nuclear diagnostics

    International Nuclear Information System (INIS)

    Eyer, H.H.

    1976-01-01

    A high speed imaging system based on state-of-the-art photosensor arrays has been designed for use in nuclear diagnostics. The system is comprised of a front-end rapid-scan solid-state camera, a high speed digitizer, and a PCM line driver in a downhole package and a memory buffer system in an uphole trailer. The downhole camera takes a ''snapshot'' of a nuclear device created flux stream, digitizes the image and transmits it to the uphole memory system before being destroyed. The memory system performs two functions: it retains the data for local display and processing by a microprocessor, and it buffers the data for retransmission at slower rates to the LLL computational facility (NADS). The impetus for such a system as well as its operation is discussed. Also discussed are new systems under development which incorporate higher data rates and more resolution

  19. Interactions in the aqueous phase and adsorption at the air-water interface of caseinoglycomacropeptide (GMP) and beta-lactoglobulin mixed systems.

    Science.gov (United States)

    Martinez, María J; Sánchez, Cecilio Carrera; Patino, Juan M Rodríguez; Pilosof, Ana M R

    2009-01-01

    The aim of this work was to study the interactions and adsorption of caseinoglycomacropeptide (GMP) and GMP:beta-lactoglobulin (beta-lg) mixed system in the aqueous phase and at the air-water interface. The existence of associative interactions between GMP and beta-lg in the aqueous phase was investigated by dynamic light scattering, differential scanning calorimetry (DSC), fluorometry and native PAGE-electrophoresis. The surface pressure isotherm and the static and dynamic surface pressure were determined by tensiometry and surface dilatational properties. The results showed that GMP presented higher surface activity than beta-lg at a concentration of 4%wt but beta-lg showed higher film forming ability. In the mixed systems beta-lg dominated the static and dynamic surface pressure and the rheological properties of interfacial films suggesting that beta-lg hinders GMP adsorption because, in simple competition, GMP should dominate because of its higher surface activity. The surface predominance of beta-lg can be attributed to binding of GMP to beta-lg in the aqueous phase that prevents GMP adsorption on its own.

  20. NMR imaging of the cardiovascular system

    International Nuclear Information System (INIS)

    Canby, R.C.; Evanochko, W.T.; Pohost, G.M.

    1986-01-01

    Proton nuclear magnetic resonance (NMR) imaging permits high-resolution tomographic and three-dimensional images of the human body to be obtained without exposure to ionizing radiation. Such imaging not only yields anatomic resolution comparable to X-ray examinations but also provides a potential means to discriminate between healthy tissue and diseased tissue. This potential is based on certain NMR properties known as relaxation times, which determine, in part, the signal intensity in an image. These properties are related to such factors as the sizes and concentrations of proteins and mobile lipids and the compartmentalization of the protons of water. Although NMR imaging (also called magnetic resonance imaging, MRI) is becoming widely available for clinical use, application to the cardiovascular system, though promising, remains primarily a research tool. Gated proton NMR imaging can generate cardiac images with excellent morphologic detail and contrast; however, its ultimate importance as a cardiovascular diagnostic modality will depend on the development of several unique applications. These applications are discussed in this paper

  1. A new approach to beta-gamma coincidence counting. Advance report on the Samar electronic system

    International Nuclear Information System (INIS)

    Carlos, J. E. de; Granados, C. E.

    1972-01-01

    In 4π β-γ coincidence measurements, precision on the evaluation of coincidence counting losses is made difficult because of complex overlapping effects between theβ--and γ-side dead times due to pre cursive counted events. In this context the SAMAR electronic system is aimed to give a precise way of automatic counting and reduce the need for calculated corrections. This report describes its configuration and basic features. The SAMAR has been conceived in such a manner that both beta and gamma chains are sharing a common and non extending dead-time which is simultaneously applied to both channels. The shared dead time is made to be the only one inserted throughout the chains. Overlapping effects vanish and the three counting channels have identical transmission ratios. A new dead-time circuit based on fast linear gates as blocking elements has been developed. Application of the two-oscillator Muller's method evidences a fully non-extending character. Automatism is implemented by using a live timer corrective channel controlling the counting scalers. (Author) 21 refs

  2. Modification of heating system on HeaTiNG-02 test section of beta test loop

    International Nuclear Information System (INIS)

    Sagino; Dedy Haryanto; Riswan Djambiar; Edy Sumarno

    2013-01-01

    Modifications have been carried out on the heating test section heating-02 on the integration strand Beta Test (UUB). The activities carried out to overcome the obstacles that arise in the test section when used. Constraint that often arises is the fall of the heating source super chantal when it reaches a certain temperature. To mitigate the super chantal is initially converted into a horizontal vertical position. Change from vertical to horizontal position on super chantal aims to stabilize the position of super chantal, so it needs to be modified in the heating system. Modification activities include manufacturing, installation and testing of super chantal and refractory stone as super chantal support. Manufacturing refractory stone formation and assembly into the heater in accordance with design modifications that have been done in electromechanical workshop obtained using some machine tools. Testing results of fabrication has been done by providing voltage 110 volts until it reaches operating temperature 400°C. Test results obtained super chantal stable position when it reaches operating temperature, and heater of heating-02 test section feasible to be used for experiments. (author)

  3. Modeling digital breast tomosynthesis imaging systems for optimization studies

    Science.gov (United States)

    Lau, Beverly Amy

    Digital breast tomosynthesis (DBT) is a new imaging modality for breast imaging. In tomosynthesis, multiple images of the compressed breast are acquired at different angles, and the projection view images are reconstructed to yield images of slices through the breast. One of the main problems to be addressed in the development of DBT is the optimal parameter settings to obtain images ideal for detection of cancer. Since it would be unethical to irradiate women multiple times to explore potentially optimum geometries for tomosynthesis, it is ideal to use a computer simulation to generate projection images. Existing tomosynthesis models have modeled scatter and detector without accounting for oblique angles of incidence that tomosynthesis introduces. Moreover, these models frequently use geometry-specific physical factors measured from real systems, which severely limits the robustness of their algorithms for optimization. The goal of this dissertation was to design the framework for a computer simulation of tomosynthesis that would produce images that are sensitive to changes in acquisition parameters, so an optimization study would be feasible. A computer physics simulation of the tomosynthesis system was developed. The x-ray source was modeled as a polychromatic spectrum based on published spectral data, and inverse-square law was applied. Scatter was applied using a convolution method with angle-dependent scatter point spread functions (sPSFs), followed by scaling using an angle-dependent scatter-to-primary ratio (SPR). Monte Carlo simulations were used to generate sPSFs for a 5-cm breast with a 1-cm air gap. Detector effects were included through geometric propagation of the image onto layers of the detector, which were blurred using depth-dependent detector point-spread functions (PRFs). Depth-dependent PRFs were calculated every 5-microns through a 200-micron thick CsI detector using Monte Carlo simulations. Electronic noise was added as Gaussian noise as a

  4. Image change detection systems, methods, and articles of manufacture

    Science.gov (United States)

    Jones, James L.; Lassahn, Gordon D.; Lancaster, Gregory D.

    2010-01-05

    Aspects of the invention relate to image change detection systems, methods, and articles of manufacture. According to one aspect, a method of identifying differences between a plurality of images is described. The method includes loading a source image and a target image into memory of a computer, constructing source and target edge images from the source and target images to enable processing of multiband images, displaying the source and target images on a display device of the computer, aligning the source and target edge images, switching displaying of the source image and the target image on the display device, to enable identification of differences between the source image and the target image.

  5. Neuronavigation in brain tumor surgery:clinical beta-phase of the Oulu Neuronavigator System

    OpenAIRE

    Schiffbauer, H. (Hagen)

    1999-01-01

    Abstract Interactive image-guided neurosurgery for the resection of brain tumors was developed within the last 10 years at different neurosurgical centers around the world to improve the safety of the surgery and the functional outcome of the patients. Since 1987, the Oulu Neuronavigator System, consisting mainly of a mechanical arm, visualization software, an ultrasound transducer and a computer, was developed at the Neurosurgical Research Unit, University of Oulu, Finland. It was the fir...

  6. Active gated imaging in driver assistance system

    Science.gov (United States)

    Grauer, Yoav

    2014-04-01

    In this paper, we shall present the active gated imaging system (AGIS) in relation to the automotive field. AGIS is based on a fast-gated camera and pulsed illuminator, synchronized in the time domain to record images of a certain range of interest. A dedicated gated CMOS imager sensor and near infra-red (NIR) pulsed laser illuminator, is presented in this paper to provide active gated technology. In recent years, we have developed these key components and learned the system parameters, which are most beneficial to nighttime (in all weather conditions) driving in terms of field of view, illumination profile, resolution, and processing power. We shall present our approach of a camera-based advanced driver assistance systems (ADAS) named BrightEye™, which makes use of the AGIS technology in the automotive field.

  7. GMP-compliant automated synthesis of [{sup 18}F]AV-45 (Florbetapir F 18) for imaging {beta}-amyloid plaques in human brain

    Energy Technology Data Exchange (ETDEWEB)

    Yao, C.-H. [Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, Taiwan (China); Lin, K.-J. [Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, Taiwan (China); Department of Medical Imaging and Radiological Sciences, Chang Gung University, 259 Wen-Hua 1st Road, Kweishan, Taoyuan 333, Taiwan (China); Weng, C.-C. [Department of Medical Imaging and Radiological Sciences, Chang Gung University, 259 Wen-Hua 1st Road, Kweishan, Taoyuan 333, Taiwan (China); Hsiao, I.-T. [Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, Taiwan (China); Department of Medical Imaging and Radiological Sciences, Chang Gung University, 259 Wen-Hua 1st Road, Kweishan, Taoyuan 333, Taiwan (China); Ting, Y.-S. [Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, Taiwan (China); Yen, T.-C. [Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, Taiwan (China); Department of Medical Imaging and Radiological Sciences, Chang Gung University, 259 Wen-Hua 1st Road, Kweishan, Taoyuan 333, Taiwan (China); Jan, T.-R. [Department and Graduate Institute of Veterinary Medicine, National Taiwan University, Taipei, Taiwan (China); Skovronsky, Daniel [Avid Radiopharmaceuticals, Inc., Philadelphia, PA 19104 (United States); Kung, M.-P. [Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, Taiwan (China); Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104 (United States); Wey, S.-P., E-mail: spwey@mail.cgu.edu.t [Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, Taiwan (China); Department of Medical Imaging and Radiological Sciences, Chang Gung University, 259 Wen-Hua 1st Road, Kweishan, Taoyuan 333, Taiwan (China)

    2010-12-15

    We report herein the Good Manufacturing Practice (GMP)-compliant automated synthesis of {sup 18}F-labeled styrylpyridine, AV-45 (Florbetapir), a novel tracer for positron emission tomography (PET) imaging of {beta}-amyloid (A{beta}) plaques in the brain of Alzheimer's disease patients. [{sup 18}F]AV-45 was prepared in 105 min using a tosylate precursor with Sumitomo modules for radiosynthesis under GMP-compliant conditions. The overall yield was 25.4{+-}7.7% with a final radiochemical purity of 95.3{+-}2.2% (n=19). The specific activity of [{sup 18}F]AV-45 reached as high as 470{+-}135 TBq/mmol (n=19). The present studies show that [{sup 18}F]AV-45 can be manufactured under GMP-compliant conditions and could be widely available for routine clinical use.

  8. Speculative Betas

    OpenAIRE

    Harrison Hong; David Sraer

    2012-01-01

    We provide a model for why high beta assets are more prone to speculative overpricing than low beta ones. When investors disagree about the common factor of cash-flows, high beta assets are more sensitive to this macro-disagreement and experience a greater divergence-of-opinion about their payoffs. Short-sales constraints for some investors such as retail mutual funds result in high beta assets being over-priced. When aggregate disagreement is low, expected return increases with beta due to r...

  9. Improving documentation of a beta-blocker quality measure through an anesthesia information management system and real-time notification of documentation errors.

    Science.gov (United States)

    Nair, Bala G; Peterson, Gene N; Newman, Shu-Fang; Wu, Wei-Ying; Kolios-Morris, Vickie; Schwid, Howard A

    2012-06-01

    Continuation of perioperative beta-blockers for surgical patients who are receiving beta-blockers prior to arrival for surgery is an important quality measure (SCIP-Card-2). For this measure to be considered successful, name, date, and time of the perioperative beta-blocker must be documented. Alternately, if the beta-blocker is not given, the medical reason for not administering must be documented. Before the study was conducted, the institution lacked a highly reliable process to document the date and time of self-administration of beta-blockers prior to hospital admission. Because of this, compliance with the beta-blocker quality measure was poor (-65%). To improve this measure, the anesthesia care team was made responsible for documenting perioperative beta-blockade. Clear documentation guidelines were outlined, and an electronic Anesthesia Information Management System (AIMS) was configured to facilitate complete documentation of the beta-blocker quality measure. In addition, real-time electronic alerts were generated using Smart Anesthesia Messenger (SAM), an internally developed decision-support system, to notify users concerning incomplete beta-blocker documentation. Weekly compliance for perioperative beta-blocker documentation before the study was 65.8 +/- 16.6%, which served as the baseline value. When the anesthesia care team started documenting perioperative beta-blocker in AIMS, compliance was 60.5 +/- 8.6% (p = .677 as compared with baseline). Electronic alerts with SAM improved documentation compliance to 94.6 +/- 3.5% (p documentation and (2) enhance features in the electronic medical systems to alert the user concerning incomplete documentation.

  10. Consultation system for image diagnosis: Report formation support system

    International Nuclear Information System (INIS)

    Ikeda, M.; Sakuma, S.; Ishigaki, T.; Suzuki, K.; Oikawa, K.

    1987-01-01

    The authors developed a consultation system for image diagnosis, involving artificial intelligence ideas. In this system, the authors proposed a new report formation support system and implemented it in lymphangiography. This support system starts with the input of image interpretation. The input process is made mainly by selecting items. This system encodes the input findings into the semantic network, which is represented as a directed graph, and it reserves them into the knowledge database in the above structure. Finally, the output (report) is made in the near natural language, which corresponds to the input findings

  11. Fiber optic neutron imaging system: calibration

    International Nuclear Information System (INIS)

    Malone, R.M.; Gow, C.E.; Thayer, D.R.

    1981-01-01

    Two neutron imaging experiments using fiber optics have been performed at the Nevada Test Site. In each experiment, an array of scintillator fluor tubes is exposed to neutrons. Light is coupled out through radiation resistant PCS fibers (8-m long) into high-bandwidth, graded index fibers. For image reconstruction to be accurate, common timing differences and transmission variations between fiber optic channels are needed. The calibration system featured a scanning pulsed dye laser, a specially designed fiber optic star coupler, a tektronix 7912AD transient digitizer, and a DEC PDP 11/34 computing system

  12. PET imaging of {alpha}{sub v}{beta}{sub 3} integrin expression in tumours with {sup 68}Ga-labelled mono-, di- and tetrameric RGD peptides

    Energy Technology Data Exchange (ETDEWEB)

    Dijkgraaf, Ingrid; Franssen, Gerben M.; Oyen, Wim J.G.; Boerman, Otto C. [Radboud University Nijmegen Medical Centre, Department of Nuclear Medicine, P.O. Box 9101, Nijmegen (Netherlands); Yim, Cheng-Bin [Radboud University Nijmegen Medical Centre, Department of Nuclear Medicine, P.O. Box 9101, Nijmegen (Netherlands); Utrecht University, Department of Medicinal Chemistry and Chemical Biology, Utrecht Institute for Pharmaceutical Sciences, Utrecht (Netherlands); Schuit, Robert C. [VU University Medical Centre, Department of Nuclear Medicine and PET Research, P.O. Box 7057, Amsterdam (Netherlands); Luurtsema, Gert [University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging, Hanzeplein 1, P.O. Box 30.001, Groningen (Netherlands); Liu, Shuang [Purdue University, School of Health Sciences, West Lafayette, IN (United States)

    2011-01-15

    Due to the restricted expression of {alpha}{sub v}{beta}{sub 3} in tumours, {alpha}{sub v}{beta}{sub 3} is considered a suitable receptor for tumour targeting. In this study the {alpha}{sub v}{beta}{sub 3}-binding characteristics of {sup 68}Ga-labelled monomeric, dimeric and tetrameric RGD peptides were determined and compared with their {sup 111}In-labelled counterparts. A monomeric (E-c(RGDfK)), a dimeric (E-[c(RGDfK)]{sub 2}) and a tetrameric (E{l_brace}E[c(RGDfK)]{sub 2}{r_brace}{sub 2}) RGD peptide were synthesised, conjugated with DOTA and radiolabelled with {sup 68}Ga. In vitro {alpha}{sub v}{beta}{sub 3}-binding characteristics were determined in a competitive binding assay. In vivo {alpha}{sub v}{beta}{sub 3}-targeting characteristics of the compounds were assessed in mice with subcutaneously growing SK-RC-52 xenografts. In addition, microPET images were acquired using a microPET/CT scanner. The IC{sub 50} values for the Ga(III)-labelled DOTA-E-c(RGDfK), DOTA-E-[c(RGDfK)]{sub 2} and DOTA-E{l_brace}E[c(RGDfK)]{sub 2}{r_brace}{sub 2} were 23.9 {+-} 1.22, 8.99 {+-} 1.20 and 1.74 {+-} 1.18 nM, respectively, and were similar to those of the In(III)-labelled mono-, di- and tetrameric RGD peptides (26.6 {+-} 1.15, 3.34 {+-} 1.16 and 1.80 {+-} 1.37 nM, respectively). At 2 h post-injection, tumour uptake of the {sup 68}Ga-labelled mono-, di- and tetrameric RGD peptides (3.30 {+-} 0.30, 5.24 {+-} 0.27 and 7.11 {+-} 0.67%ID/g, respectively) was comparable to that of their {sup 111}In-labelled counterparts (2.70 {+-} 0.29, 5.61 {+-} 0.85 and 7.32 {+-} 2.45%ID/g, respectively). PET scans were in line with the biodistribution data. On all PET scans, the tumour could be clearly visualised. The integrin affinity and the tumour uptake followed the order of DOTA-tetramer > DOTA-dimer > DOTA-monomer. The {sup 68}Ga-labelled tetrameric RGD peptide has excellent characteristics for imaging of {alpha}{sub v} {beta}{sub 3} expression with PET. (orig.)

  13. X-ray image subtracting system

    International Nuclear Information System (INIS)

    Wesbey, W.H.; Keyes, G.S.; Georges, J.-P.J.

    1982-01-01

    An X-ray image subtracting system for making low contrast structures in the images more conspicuous is described. An X-ray source projects successive high and low energy X-ray beam pulses through a body and the resultant X-ray images are converted to optical images. Two image pick-up devices such as TV cameras that have synchronously operated shutters receive the alternate images and convert them to corresponding analog video signals. In some embodiments, the analog signals are converted to a matrix of digital pixel signals that are variously processed and subtracted and converted to signals for driving a TV monitor display and analog storage devices. In other embodiments the signals are processed and subtracted in analog form for display. The high and low energy pulses can follow each other immediately so good registration between subtracted images is obtainable even though the anatomy is in motion. The energy levels of the X-ray pulses are chosen to maximize the difference in attenuation between the anatomical structure which is to be subtracted out and that which remains. (author)

  14. Advances in Small Animal Imaging Systems

    International Nuclear Information System (INIS)

    Loudos, George K.

    2007-01-01

    The rapid growth in genetics and molecular biology combined with the development of techniques for genetically engineering small animals has led to an increased interest in in vivo laboratory animal imaging during the past few years. For this purpose, new instrumentation, data acquisition strategies, and image processing and reconstruction techniques are being developed, researched and evaluated. The aim of this article is to give a short overview of the state of the art technologies for high resolution and high sensitivity molecular imaging techniques, primarily positron emission tomography (PET) and single photon emission computed tomography (SPECT). The basic needs of small animal imaging will be described. The evolution in instrumentation in the past two decades, as well as the commercially available systems will be overviewed. Finally, the new trends in detector technology and preliminary results from challenging applications will be presented. For more details a number of references are provided

  15. SPECT imaging of dopamine and serotonin transporters with [[sup 123]I][beta]-CIT. Binding kinetics in the human brain

    Energy Technology Data Exchange (ETDEWEB)

    Bruecke, T; Asenbaum, S; Frassine, H; Podreka, I [Vienna Univ. (Austria). Neurologische Klinik; Kornhuber, J [Wuerzburg Univ. (Germany); Angelberger, P [Oesterreichisches Forschungszentrum Seibersdorf GmbH (Austria)

    1993-01-01

    Single photon emission computerized tomography (SPECT) studies in non-human primates have previously shown that the cocaine derivative [[sup 123]I]-2-[beta]-carbomethoxy-3-[beta]-(4-iodophenyl)-tropane ([[sup 123]I][beta]-CIT) labels dopamine transporters in the striatum and serotonin transporters in the hypothalamus-midbrain area. Here, we report on the regional kinetic uptake of [[sup 123]I][beta]-CIT in the brain of 4 normal volunteers and 2 patients with Parkinson's disease. In healthy subjects striatal activity increased slowly to reach peak values at about 20 hours post injection. In the hypothalamus-midbrain area peak activities were observed at about 4 hours with a slow decrease thereafter. Low activity was observed in cortical and cerebellar areas. The striatal to cerebellar ratio was about 4 after 5 hours and 9 after 20 hours. In 2 patients with idiopathic Parkinson's disease striatal activity was markedly decreased while the activity in hypothalamus-midbrain areas was only diminished. Uptake into cortical and cerebellar areas appeared to be unchanged in Parkinson's disease. Consequently, in Parkinson's disease the striatal to cerebellar ratio was decreased to values around 2.5 after 20 hours. These preliminary methodological studies suggest that [[sup 123]I][beta]-CIT is a useful SPECT ligand for studying dopamine and possibly also serotonin transporters in the living human brain.

  16. Effects of thyroid hormone on. beta. -adrenergic responsiveness of aging cardiovascular systems

    Energy Technology Data Exchange (ETDEWEB)

    Tsujimoto, G.; Hashimoto, K.; Hoffman, B.B.

    1987-03-01

    The authors have compared the effects of ..beta..-adrenergic stimulation on the heart and peripheral vasculature of young (2-mo-old) and older (12-mo-old) rats both in the presence and absence of triiodothyronine (T/sub 3/)-induced hyperthyroidism. The hemodynamic consequences of T/sub 3/ treatment were less prominent in the aged hyperthyroid rats compared with young hyperthyroid rats (both in intact and pithed rats). There was a decrease in sensitivity of chronotropic responsiveness to isoproterenol in older pithed rats, which was apparently reversed by T/sub 3/ treatment. The number and affinity of myocardial ..beta..-adrenergic receptor sites measured by (/sup 125/I)cyanopindolol were not significantly different in young and older control rats; also, ..beta..-receptor density increased to a similar extent in both young and older T/sub 3/-treated rats. The ability of isoproterenol to relax mesenteric arterial rings, markedly blunted in older rats, was partially restored by T/sub 3/ treatment without their being any change in isoproterenol-mediated relaxation in the arterial preparation from young rats. The number and affinity of the ..beta..-adrenergic receptors measured in the mesenteric arteries was unaffected by either aging or T/sub 3/ treatment. The data suggest that effects of thyroid hormone and age-related alterations of cardiovascular responsiveness to ..beta..-adrenergic stimulation are interrelated in a complex fashion with a net result that the hyperkinetic cardiovascular manifestations in hyperthyroidism are attenuated in the older animals.

  17. Parallel asynchronous systems and image processing algorithms

    Science.gov (United States)

    Coon, D. D.; Perera, A. G. U.

    1989-01-01

    A new hardware approach to implementation of image processing algorithms is described. The approach is based on silicon devices which would permit an independent analog processing channel to be dedicated to evey pixel. A laminar architecture consisting of a stack of planar arrays of the device would form a two-dimensional array processor with a 2-D array of inputs located directly behind a focal plane detector array. A 2-D image data stream would propagate in neuronlike asynchronous pulse coded form through the laminar processor. Such systems would integrate image acquisition and image processing. Acquisition and processing would be performed concurrently as in natural vision systems. The research is aimed at implementation of algorithms, such as the intensity dependent summation algorithm and pyramid processing structures, which are motivated by the operation of natural vision systems. Implementation of natural vision algorithms would benefit from the use of neuronlike information coding and the laminar, 2-D parallel, vision system type architecture. Besides providing a neural network framework for implementation of natural vision algorithms, a 2-D parallel approach could eliminate the serial bottleneck of conventional processing systems. Conversion to serial format would occur only after raw intensity data has been substantially processed. An interesting challenge arises from the fact that the mathematical formulation of natural vision algorithms does not specify the means of implementation, so that hardware implementation poses intriguing questions involving vision science.

  18. Slow cortical potential and theta/beta neurofeedback training in adults: effects on attentional processes, and motor system excitability

    Directory of Open Access Journals (Sweden)

    Petra eStuder

    2014-07-01

    Full Text Available Neurofeedback (NF is being successfully applied, among others, in children with ADHD and as a peak performance training in healthy subjects. However, the neuronal mechanisms mediating a successful NF training have not yet been sufficiently uncovered for both theta/beta (T/B, and slow cortical potential (SCP training, two protocols established in NF in ADHD. In the present randomized controlled investigation in adults without a clinical diagnosis (n = 59, the specificity of the effects of these two NF protocols on attentional processes, and motor system excitability were to be examined, focusing on the underlying neuronal mechanisms. NF training consisted of 10 double sessions, and self-regulation skills were analyzed. Pre- and post-training assessments encompassed performance and event-related potential measures during an attention task, and motor system excitability assessed by transcranial magnetic stimulation. Some NF protocol specific effects have been obtained. However, due to the limited sample size medium effects didn’t reach the level of significance. Self-regulation abilities during negativity trials of the SCP training were associated with increased contingent negative variation amplitudes, indicating improved resource allocation during cognitive preparation. Theta/beta training was associated with increased response speed and decreased target-P3 amplitudes after successful theta/beta regulation suggested reduced attentional resources necessary for stimulus evaluation. Motor system excitability effects after theta/beta training paralleled the effects of methylphenidate. Overall, our results are limited by the non-sufficiently acquired self-regulation skills, but some specific effects between good and poor learners could be described. Future studies with larger sample sizes and sufficient acquisition of self-regulation skills are needed to further evaluate the protocol specific effects on attention and motor system excitability

  19. Investigation into kinetics of redox interaction in the system Ce(4). beta. -diketonate-additional ligand

    Energy Technology Data Exchange (ETDEWEB)

    Anufrieva, S.I.; Snezhko, N.I.; Pechurova, N.I.; Martynenko, L.N.; Spitsyn, V.I. (Moskovskij Gosudarstvennyj Univ. (USSR))

    1981-07-01

    The rate of reduction of ..beta..-diketonate complexes of Ce(4) to Ce(3) ..beta..-diketonates in benzene solution in the presence and in the absence of additional ligands is studied using spectrophotometry. The rate of reduction of Ce(4) ..beta..-diketonates increases in the series Ce(TTFA)/sub 4/triphenylphosphine oxide>tributyl phosphate.

  20. Semiautomatic digital imaging system for cytogenetic analysis

    International Nuclear Information System (INIS)

    Chaubey, R.C.; Chauhan, P.C.; Bannur, S.V.; Kulgod, S.V.; Chadda, V.K.; Nigam, R.K.

    1999-08-01

    The paper describes a digital image processing system, developed indigenously at BARC for size measurement of microscopic biological objects such as cell, nucleus and micronucleus in mouse bone marrow; cytochalasin-B blocked human lymphocytes in-vitro; numerical counting and karyotyping of metaphase chromosomes of human lymphocytes. Errors in karyotyping of chromosomes by the imaging system may creep in due to lack of well-defined position of centromere or extensive bending of chromosomes, which may result due to poor quality of preparation. Good metaphase preparations are mandatory for precise and accurate analysis by the system. Additional new morphological parameters about each chromosome have to be incorporated to improve the accuracy of karyotyping. Though the experienced cytogenetisist is the final judge; however, the system assists him/her to carryout analysis much faster as compared to manual scoring. Further, experimental studies are in progress to validate different software packages developed for various cytogenetic applications. (author)

  1. Imaging of the fetal central nervous system

    NARCIS (Netherlands)

    Pistorius, L.R.

    2008-01-01

    Introduction : Ultrasound and MR imaging of the fetal central nervous system (CNS) develop at an ever-increasing rate. Theoretically, the two modalities should be synergistic, but a literature review revealed the difficulties of determining the merit of either technique and revealed gaps in our

  2. First images of a digital autoradiography system based on a Medipix2 hybrid silicon pixel detector.

    Science.gov (United States)

    Mettivier, Giovanni; Montesi, Maria Cristina; Russo, Paolo

    2003-06-21

    We present the first images of beta autoradiography obtained with the high-resolution hybrid pixel detector consisting of the Medipix2 single photon counting read-out chip bump-bonded to a 300 microm thick silicon pixel detector. This room temperature system has 256 x 256 square pixels of 55 microm pitch (total sensitive area of 14 x 14 mm2), with a double threshold discriminator and a 13-bit counter in each pixel. It is read out via a dedicated electronic interface and control software, also developed in the framework of the European Medipix2 Collaboration. Digital beta autoradiograms of 14C microscale standard strips (containing separate bands of increasing specific activity in the range 0.0038-32.9 kBq g(-1)) indicate system linearity down to a total background noise of 1.8 x 10(-3) counts mm(-2) s(-1). The minimum detectable activity is estimated to be 0.012 Bq for 36,000 s exposure and 0.023 Bq for 10,800 s exposure. The measured minimum detection threshold is less than 1600 electrons (equivalent to about 6 keV Si). This real-time system for beta autoradiography offers lower pixel pitch and higher sensitive area than the previous Medipix1-based system. It has a 14C sensitivity better than that of micro channel plate based systems, which, however, shows higher spatial resolution and sensitive area.

  3. Global kink and ballooning modes in high-beta systems and stability of toroidal drift modes

    International Nuclear Information System (INIS)

    Galvao, R.M.O.; Goedbloed, J.P.; Rem, J.; Sakanaka, P.H.; Schep, T.J.; Venema, M.

    1983-01-01

    A numerical code (HBT) has been developed which solves for the equilibrium, global stability and high-n stability of plasmas with arbitrary cross-section. Various plasmas are analysed for their stability to these modes in the high-beta limit. Screw-pinch equilibria are stable to high-n ballooning modes up to betas of 18%. The eigenmode equation for drift waves is analysed numerically. The toroidal branch is shown to be destabilized by the non-adiabatic response of trapped and circulating particles. (author)

  4. A recommender system for medical imaging diagnostic.

    Science.gov (United States)

    Monteiro, Eriksson; Valente, Frederico; Costa, Carlos; Oliveira, José Luís

    2015-01-01

    The large volume of data captured daily in healthcare institutions is opening new and great perspectives about the best ways to use it towards improving clinical practice. In this paper we present a context-based recommender system to support medical imaging diagnostic. The system relies on data mining and context-based retrieval techniques to automatically lookup for relevant information that may help physicians in the diagnostic decision.

  5. PET imaging of the autonomic nervous system

    International Nuclear Information System (INIS)

    THACKERAY, James T.; BENGEL, Frank M.

    2016-01-01

    The autonomic nervous system is the primary extrinsic control of heart rate and contractility, and is subject to adaptive and maladaptive changes in cardiovascular disease. Consequently, noninvasive assessment of neuronal activity and function is an attractive target for molecular imaging. A myriad of targeted radiotracers have been developed over the last 25 years for imaging various components of the sympathetic and parasympathetic signal cascades. While routine clinical use remains somewhat limited, a number of larger scale studies in recent years have supplied momentum to molecular imaging of autonomic signaling. Specifically, the findings of the ADMIRE HF trial directly led to United States Food and Drug Administration approval of 123I-metaiodobenzylguanidine (MIBG) for Single Photon Emission Computed Tomography (SPECT) assessment of sympathetic neuronal innervation, and comparable results have been reported using the analogous PET agent 11C-meta-hydroxyephedrine (HED). Due to the inherent capacity for dynamic quantification and higher spatial resolution, regional analysis may be better served by PET. In addition, preliminary clinical and extensive preclinical experience has provided a broad foundation of cardiovascular applications for PET imaging of the autonomic nervous system. Recent years have witnessed the growth of novel quantification techniques, expansion of multiple tracer studies, and improved understanding of the uptake of different radiotracers, such that the transitional biology of dysfunctional subcellular catecholamine handling can be distinguished from complete denervation. As a result, sympathetic neuronal molecular imaging is poised to play a role in individualized patient care, by stratifying cardiovascular risk, visualizing underlying biology, and guiding and monitoring therapy.

  6. Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer’s disease

    Science.gov (United States)

    Zhang, Xueli; Tian, Yanli; Zhang, Can; Tian, Xiaoyu; Ross, Alana W.; Moir, Robert D.; Sun, Hongbin; Tanzi, Rudolph E.; Moore, Anna; Ran, Chongzhao

    2015-01-01

    Near-infrared fluorescence (NIRF) molecular imaging has been widely applied to monitoring therapy of cancer and other diseases in preclinical studies; however, this technology has not been applied successfully to monitoring therapy for Alzheimer’s disease (AD). Although several NIRF probes for detecting amyloid beta (Aβ) species of AD have been reported, none of these probes has been used to monitor changes of Aβs during therapy. In this article, we demonstrated that CRANAD-3, a curcumin analog, is capable of detecting both soluble and insoluble Aβ species. In vivo imaging showed that the NIRF signal of CRANAD-3 from 4-mo-old transgenic AD (APP/PS1) mice was 2.29-fold higher than that from age-matched wild-type mice, indicating that CRANAD-3 is capable of detecting early molecular pathology. To verify the feasibility of CRANAD-3 for monitoring therapy, we first used the fast Aβ-lowering drug LY2811376, a well-characterized beta-amyloid cleaving enzyme-1 inhibitor, to treat APP/PS1 mice. Imaging data suggested that CRANAD-3 could monitor the decrease in Aβs after drug treatment. To validate the imaging capacity of CRANAD-3 further, we used it to monitor the therapeutic effect of CRANAD-17, a curcumin analog for inhibition of Aβ cross-linking. The imaging data indicated that the fluorescence signal in the CRANAD-17–treated group was significantly lower than that in the control group, and the result correlated with ELISA analysis of brain extraction and Aβ plaque counting. It was the first time, to our knowledge, that NIRF was used to monitor AD therapy, and we believe that our imaging technology has the potential to have a high impact on AD drug development. PMID:26199414

  7. Prototype system for proton beam range measurement based on gamma electron vertex imaging

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Han Rim [Neutron Utilization Technology Division, Korea Atomic Energy Research Institute, 111, Daedeok-daero 989beon-gil, Yuseong-gu, Daejeon 34057 (Korea, Republic of); Kim, Sung Hun; Park, Jong Hoon [Department of Nuclear Engineering, Hanyang University, Seongdong-gu, Seoul 04763 (Korea, Republic of); Jung, Won Gyun [Heavy-ion Clinical Research Division, Korean Institute of Radiological & Medical Sciences, Seoul 01812 (Korea, Republic of); Lim, Hansang [Department of Electronics Convergence Engineering, Kwangwoon University, Seoul 01897 (Korea, Republic of); Kim, Chan Hyeong, E-mail: chkim@hanyang.ac.kr [Department of Nuclear Engineering, Hanyang University, Seongdong-gu, Seoul 04763 (Korea, Republic of)

    2017-06-11

    In proton therapy, for both therapeutic effectiveness and patient safety, it is very important to accurately measure the proton dose distribution, especially the range of the proton beam. For this purpose, recently we proposed a new imaging method named gamma electron vertex imaging (GEVI), in which the prompt gammas emitting from the nuclear reactions of the proton beam in the patient are converted to electrons, and then the converted electrons are tracked to determine the vertices of the prompt gammas, thereby producing a 2D image of the vertices. In the present study, we developed a prototype GEVI system, including dedicated signal processing and data acquisition systems, which consists of a beryllium plate (= electron converter) to convert the prompt gammas to electrons, two double-sided silicon strip detectors (= hodoscopes) to determine the trajectories of those converted electrons, and a plastic scintillation detector (= calorimeter) to measure their kinetic energies. The system uses triple coincidence logic and multiple energy windows to select only the events from prompt gammas. The detectors of the prototype GEVI system were evaluated for electronic noise level, energy resolution, and time resolution. Finally, the imaging capability of the GEVI system was tested by imaging a {sup 90}Sr beta source, a {sup 60}Co gamma source, and a 45-MeV proton beam in a PMMA phantom. The overall results of the present study generally show that the prototype GEVI system can image the vertices of the prompt gammas produced by the proton nuclear interactions.

  8. Low-level multicounter {beta}/{gamma} systems with external guards in surface and shallow underground laboratories

    Energy Technology Data Exchange (ETDEWEB)

    Theodorsson, P [Iceland Univ. (Iceland). Science Inst.

    1997-03-01

    When weak samples are measured it is important that they can be given ample counting time in order to obtain satisfactory accuracy and that the background count rate can be checked well. This calls for a high counting capacity, which multidetectors can bring us. I will discuss development possibilities of low-level {beta}/{gamma} multidetector systems with an external anticosmic shield that will in many cases be operated in underground laboratories. These simple and low-cost system can frequently help us in increasing the number of detectors. Three concepts are combined in these systems: (1) multidetectors, (2) an external anticosmic (or guard) detector arrangement and (3) overburden shielding. (orig.)

  9. Magnetic resonance imaging signal reduction may precede volume loss in the pituitary gland of transfusion-dependent beta-thalassemic patients

    Energy Technology Data Exchange (ETDEWEB)

    Hekmatnia, Ali; Rahmani, Ali Asghar; Adibi, Atoosa (Image Processing and Signal Research Center, Dept. of Radiology, Isfahan Univ. of Medical Sciences, Isfahan (Iran)); Radmard, Amir Reza (Dept. of Radiology, Shariati Hospital, Tehran Univ. of Medical Sciences, Tehran (Iran)); Khademi, Hooman (Shariati Hospital, Tehran Univ. of Medical Sciences, Tehran (Iran)), e-mail: radmard@ams.ac.ir

    2010-01-15

    Background: Pituitary iron overload in patients with transfusion-dependent beta-thalassemia may lead to delayed puberty. Magnetic resonance imaging (MRI) has the potential to estimate tissue iron concentration by detecting its paramagnetic effect and hypophyseal damage by measuring its dimensions indirectly. Purpose: To investigate the association of pituitary MRI findings and pubertal status in thalassemic patients as well as to demonstrate any priority in appearance of them. Material and Methods: Twenty-seven beta-thalassemic patients, aged 15-25 years, were divided into 13 with (group A) and 14 without hypogonadism (group B), matched by age, gender, duration of transfusion, and chelation therapy. Thirty-eight age- and sex-adjusted healthy control individuals were also included (group C). All participants underwent pituitary MRI using a 1.5T unit. Pituitary-to-fat signal intensity ratios (SIR) were calculated from coronal T2-weighted images. Estimated pituitary volumes were measured using pituitary height, width, and length on T1-weighted images. Results: The mean values of pituitary-to-fat SIRs were significantly lower in group A as compared with group B (P <0.001), and likewise group B had statistically lower values than group C (P=0.03). The pituitary height and volume were significantly decreased in group A compared to group B (P = 0.006 and P = 0.002, respectively), while these differences did not demonstrate statistically significance between groups B and C. Conclusion: Pituitary MRI findings such as signal intensity reduction and decrease in volume can be useful markers in estimating pituitary dysfunction in beta-thalassemic patients. Compared to healthy controls, lower values of pituitary-to-fat SIRs in thalassemic patients experiencing normal puberty, without marked decrease in volume, indicate that signal reduction may precede volume loss and could be expected first on MRI

  10. Radiographic imaging system for high energy radiation

    International Nuclear Information System (INIS)

    1975-01-01

    A radiographic imaging system for high energy radiation is described utilizing a detector of such radiation and a mask having regions relatively transparent to such radiation and interspersed among regions relatively opaque to such radiation. A relative motion is imparted between the mask and the detector, the detector providing a time varying signal in response to the incident radiation and in response to the relative motion. The time varying signal provides, with the aid of a decoder, an image of a source of such radiation

  11. Penn State astronomical image processing system

    International Nuclear Information System (INIS)

    Truax, R.J.; Nousek, J.A.; Feigelson, E.D.; Lonsdale, C.J.

    1987-01-01

    The needs of modern astronomy for image processing set demanding standards in simultaneously requiring fast computation speed, high-quality graphic display, large data storage, and interactive response. An innovative image processing system was designed, integrated, and used; it is based on a supermicro architecture which is tailored specifically for astronomy, which provides a highly cost-effective alternative to the traditional minicomputer installation. The paper describes the design rationale, equipment selection, and software developed to allow other astronomers with similar needs to benefit from the present experience. 9 references

  12. Radiographic imaging system for high energy radiation

    International Nuclear Information System (INIS)

    Barrett, H.H.

    1976-01-01

    A radiographic imaging system for high energy radiation utilizing a detector of such radiation and a mask having regions relatively transparent to such radiation interspersed among regions relatively opaque to such radiation is described. A relative motion is imparted between the mask and the detector, the detector providing a time varying signal in response to the incident radiation and in response to the relative motion. The time varying signal provides, with the aid of a decoder, an image of a source of such radiation

  13. Brain MR imaging of systemic lupus erythematodes

    International Nuclear Information System (INIS)

    Kobayashi, Satoshi; Suzuki, Masayuki; Ueda, Fumiaki; Arai, Kazunori; Kobayashi, Takeshi; Kadoya, Masumi; Matsui, Osamu; Takashima, Tsutomu

    1996-01-01

    Brain MR imaging of 13 patients with systemic lupus erythematodus (SLE) were reviewed. Two major findings was obtained. One was deep white matter hyperintensity (DWMH) and periventricular hyperintensity (PVH), the other was cerebral infarction. In comparison with the same age group, relatively severe brain atrophy was also observed. It was thought that these findings were induced from the vasculitis caused by SLE. However, the influence of the steroid therapy could not be excluded. No definite correlation between MR findings and clinical symptoms were seen. In conclusion, when we interpret brain MR imaging of the patients with SLE, special attention should be paid to their age. (author)

  14. Positron emission tomography imaging of adrenal masses: {sup 18}F-fluorodeoxyglucose and the 11{beta}-hydroxylase tracer {sup 11}C-metomidate

    Energy Technology Data Exchange (ETDEWEB)

    Zettinig, Georg; Becherer, Alexander; Pirich, Christian; Dudczak, Robert [Department of Nuclear Medicine, University of Vienna, Waehringer Guertel 18-20, 1090, Vienna (Austria); Ludwig Boltzmann Institute for Nuclear Medicine, University of Vienna, Vienna (Austria); Mitterhauser, Markus [Department of Nuclear Medicine, University of Vienna, Waehringer Guertel 18-20, 1090, Vienna (Austria); Department of Pharmaceutic Technology and Biopharmaceutics, University of Vienna, Vienna (Austria); Wadsak, Wolfgang; Kletter, Kurt [Department of Nuclear Medicine, University of Vienna, Waehringer Guertel 18-20, 1090, Vienna (Austria); Vierhapper, Heinrich [Department of Internal Medicine III, University of Vienna, Vienna (Austria); Niederle, Bruno [Department of Surgery, University of Vienna, Vienna (Austria)

    2004-09-01

    {sup 11}C-metomidate (MTO), a marker of 11{beta}-hydroxylase, has been suggested as a novel positron emission tomography (PET) tracer for adrenocortical imaging. Up to now, experience with this very new tracer is limited. The aims of this study were (1) to evaluate this novel tracer, (2) to point out possible advantages in comparison with{sup 18}F-fluorodeoxyglucose (FDG) and (3) to investigate in vivo the expression of 11{beta}-hydroxylase in patients with primary aldosteronism. Sixteen patients with adrenal masses were investigated using both MTO and FDG PET imaging. All patients except one were operated on. Five patients had non-functioning adrenal masses, while 11 had functioning tumours(Cushing's syndrome, n=4; Conn's syndrome, n=5; phaeochromocytoma, n=2). Thirteen patients had benign disease, whereas in three cases the adrenal mass was malignant (adrenocortical cancer, n=1; malignant phaeochromocytoma, n=1; adrenal metastasis of renal cancer, n=1). MTO imaging clearly distinguished cortical from non-cortical adrenal masses (median standardised uptake values of 18.6 and 1.9, respectively, p<0.01). MTO uptake was slightly lower in patients with Cushing's syndrome than in those with Conn's syndrome, but the difference did not reach statistical significance. The expression of 11{beta}-hydroxylase was not suppressed in the contralateral gland of patients with Conn's syndrome, whereas in Cushing's syndrome this was clearly the case. The single patient with adrenocortical carcinoma had MTO uptake in the lower range. MTO could not definitely distinguish between benign and malignant disease. FDG PET, however, identified clearly all three study patients with malignant adrenal lesions. We conclude: (1) MTO is an excellent imaging tool to distinguish adrenocortical and non-cortical lesions; (2) the in vivo expression of 11{beta}-hydroxylase is lower in Cushing's syndrome than in Conn's syndrome, and there is no suppression of the

  15. Divergent expression of 11beta-hydroxysteroid dehydrogenase and 11beta-hydroxylase genes between male morphs in the central nervous system, sonic muscle and testis of a vocal fish.

    Science.gov (United States)

    Arterbery, Adam S; Deitcher, David L; Bass, Andrew H

    2010-05-15

    The vocalizing midshipman fish, Porichthys notatus, has two male morphs that exhibit alternative mating tactics. Only territorial males acoustically court females with long duration (minutes to >1h) calls, whereas sneaker males attempt to steal fertilizations. During the breeding season, morph-specific tactics are paralleled by a divergence in relative testis and vocal muscle size, plasma levels of the androgen 11-ketotestosterone (11KT) and the glucocorticoid cortisol, and mRNA expression levels in the central nervous system (CNS) of the steroid-synthesizing enzyme aromatase (estrogen synthase). Here, we tested the hypothesis that the midshipman's two male morphs would further differ in the CNS, as well as in the testis and vocal muscle, in mRNA abundance for the enzymes 11beta-hydroxylase (11betaH) and 11beta-hydroxysteroid dehydrogenase (11betaHSD) that directly regulate both 11KT and cortisol synthesis. Quantitative real-time PCR demonstrated male morph-specific profiles for both enzymes. Territorial males had higher 11betaH and 11betaHSD mRNA levels in testis and vocal muscle. By contrast, sneaker males had the higher CNS expression, especially for 11betaHSD, in the region containing an expansive vocal pacemaker circuit that directly determines the temporal attributes of natural calls. We propose for territorial males that higher enzyme expression in testis underlies its greater plasma 11KT levels, which in vocal muscle provides both gluconeogenic and androgenic support for its long duration calling. We further propose for sneaker males that higher enzyme expression in the vocal CNS contributes to known cortisol-specific effects on its vocal physiology. Copyright 2010 Elsevier Inc. All rights reserved.

  16. Ergodization of magnetic surfaces due to finite beta effect in a helical system

    International Nuclear Information System (INIS)

    Hayashi, Takaya.

    1989-04-01

    Breaking of magnetic surfaces due to finite beta effect in a l=2 heliotron/torsatron configuration is studied by using a newly developed three dimensional equilibrium code. Breaking can be suppressed by a larger aspect ratio configuration, shaping of magnetic surface (inward shift or prolate shape), pitch modulation of helical coils, or pressure profile control. (author)

  17. A Gimbal-Stabilized Compact Hyperspectral Imaging System, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — The Gimbal-stabilized Compact Hyperspectral Imaging System (GCHIS) fully integrates multi-sensor spectral imaging, stereovision, GPS and inertial measurement,...

  18. Web Based Distributed Coastal Image Analysis System, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This project develops Web based distributed image analysis system processing the Moderate Resolution Imaging Spectroradiometer (MODIS) data to provide decision...

  19. Scattered radiation in fan beam imaging systems

    International Nuclear Information System (INIS)

    Johns, P.C.; Yaffe, M.

    1982-01-01

    Scatter-to-primary energy fluence ratios (S/P) have been studied for fan x-ray beams as used in CT scanners and slit projection radiography systems. The dependence of S/P on phantom diameter, distance from phantom to image receptor, and kilovoltage is presented. An empirical equation is given that predicts S/P over a wide range of fan beam imaging configurations. For CT body scans on a 4th-generation machine, S/P is approximately 5%. Scattered radiation can produce a significant cupping artefact in CT images which is similar to that due to beam hardening. When multiple slices are used in scanned slit radiography, they can be arranged such that the increase in S/P is negligible. Calculations of scatter-to-primary ratios for first order scattering showed that for fan beams the contribution of coherent scatter is comparable to or greater than that of incoherent first scatter

  20. System Matrix Analysis for Computed Tomography Imaging

    Science.gov (United States)

    Flores, Liubov; Vidal, Vicent; Verdú, Gumersindo

    2015-01-01

    In practical applications of computed tomography imaging (CT), it is often the case that the set of projection data is incomplete owing to the physical conditions of the data acquisition process. On the other hand, the high radiation dose imposed on patients is also undesired. These issues demand that high quality CT images can be reconstructed from limited projection data. For this reason, iterative methods of image reconstruction have become a topic of increased research interest. Several algorithms have been proposed for few-view CT. We consider that the accurate solution of the reconstruction problem also depends on the system matrix that simulates the scanning process. In this work, we analyze the application of the Siddon method to generate elements of the matrix and we present results based on real projection data. PMID:26575482

  1. A PET imaging system dedicated to mammography

    CERN Document Server

    Varela, J

    2007-01-01

    The imaging system Clear-PEM for positron emission mammography, under development within the framework of the Crystal Clear Collaboration at CERN, is presented. The detector is based on pixelized LYSO crystals optically coupled to avalanche photodiodes (APD) and readout by a fast low-noise electronic system. A dedicated digital trigger and data acquisition system is used for on-line selection of coincidence events with high efficiency, large bandwidth and negligible dead-time. The detector module performance was characterized in detail.

  2. An investigation of cerebrograph imaging system

    International Nuclear Information System (INIS)

    Chen Lianxiang; Zhang Qingling; Wang Xinhui; Luo Qikun

    1994-01-01

    A cerebrograph imaging system was investigated for the diagnosis of cerebrovascular diseases. This system can quantitatively analyse and map the regional cerebral blood flow (rCBF) and also the electroencephalography (EEG). The mapping of cerebellum-brain stem area was also realized. This system is the first one to combine the technology of nuclear medicine with electrophysiology, and thereby provide a combined information about the rCBF and the function of brain with coloured rCBF mapping, topographical EEG mapping and quantitative data at the same time. It has important value for the early diagnosis of brain diseases, especially for the cerebral vascular accident

  3. Intelligence, mapping, and geospatial exploitation system (IMAGES)

    Science.gov (United States)

    Moellman, Dennis E.; Cain, Joel M.

    1998-08-01

    This paper provides further detail to one facet of the battlespace visualization concept described in last year's paper Battlespace Situation Awareness for Force XXI. It focuses on the National Imagery and Mapping Agency (NIMA) goal to 'provide customers seamless access to tailorable imagery, imagery intelligence, and geospatial information.' This paper describes Intelligence, Mapping, and Geospatial Exploitation System (IMAGES), an exploitation element capable of CONUS baseplant operations or field deployment to provide NIMA geospatial information collaboratively into a reconnaissance, surveillance, and target acquisition (RSTA) environment through the United States Imagery and Geospatial Information System (USIGS). In a baseplant CONUS setting IMAGES could be used to produce foundation data to support mission planning. In the field it could be directly associated with a tactical sensor receiver or ground station (e.g. UAV or UGV) to provide near real-time and mission specific RSTA to support mission execution. This paper provides IMAGES functional level design; describes the technologies, their interactions and interdependencies; and presents a notional operational scenario to illustrate the system flexibility. Using as a system backbone an intelligent software agent technology, called Open Agent ArchitectureTM (OAATM), IMAGES combines multimodal data entry, natural language understanding, and perceptual and evidential reasoning for system management. Configured to be DII COE compliant, it would utilize, to the extent possible, COTS applications software for data management, processing, fusion, exploitation, and reporting. It would also be modular, scaleable, and reconfigurable. This paper describes how the OAATM achieves data synchronization and enables the necessary level of information to be rapidly available to various command echelons for making informed decisions. The reasoning component will provide for the best information to be developed in the timeline

  4. Ultrahigh resolution radiation imaging system using an optical fiber structure scintillator plate.

    Science.gov (United States)

    Yamamoto, Seiichi; Kamada, Kei; Yoshikawa, Akira

    2018-02-16

    High resolution imaging of radiation is required for such radioisotope distribution measurements as alpha particle detection in nuclear facilities or high energy physics experiments. For this purpose, we developed an ultrahigh resolution radiation imaging system using an optical fiber structure scintillator plate. We used a ~1-μm diameter fiber structured GdAlO 3 :Ce (GAP) /α-Al 2 O 3 scintillator plate to reduce the light spread. The fiber structured scintillator plate was optically coupled to a tapered optical fiber plate to magnify the image and combined with a lens-based high sensitivity CCD camera. We observed the images of alpha particles with a spatial resolution of ~25 μm. For the beta particles, the images had various shapes, and the trajectories of the electrons were clearly observed in the images. For the gamma photons, the images also had various shapes, and the trajectories of the secondary electrons were observed in some of the images. These results show that combining an optical fiber structure scintillator plate with a tapered optical fiber plate and a high sensitivity CCD camera achieved ultrahigh resolution and is a promising method to observe the images of the interactions of radiation in a scintillator.

  5. Brain dopaminergic systems : imaging with positron tomography

    Energy Technology Data Exchange (ETDEWEB)

    Baron, J C [University of Caen/INSERM U, Caen (France). CYCERON; Comar, D [E.E.C. Concerted Action on P.E.T. Investigations of Cellular Regeneration and Degeneration, Orsay (France) CEA, 91 - Orsay (France). Service Hospitalier Frederic Joliot; Farde, L [Karolinska Sjukhuset, Stockholm (Sweden); Martinot, J L; Mazoyer, B [CEA, 91 - Orsay (France). Service Hospitalier Frederic Joliot Paris-

    1991-01-01

    Imaging of the dopaminergic system in the human brain with the in vivo use of Positron Emission Tomography emerged in the late 1980s as a tool of major importance in clinical neurosciences and pharmacology. The last few years have witnessed rapid development of new radiotracers specific to receptors, reuptake sites and enzymes of the dopamine system; the application of these radiotracers has led to major break-troughs in the pathophysiology and therapy of movement disorders and schizophrenic-like psychoses. This book is the first to collect, in a single volume, state-of-the-art contributions to the various aspects of this research. Its contents address methodological issues related to the design, labelling, quantitative imaging and compartmental modeli-sation of radioligands of the post-synaptic, pre-synaptic and enzyme sites of the dopamine system and to their use in clinical research in the fields of Parkinson's disease as well as other movement disorders, psychoses and neuroleptic receptor occupancy. The chapters were written by leading European scientists in the field of PET, gathered together in Caen (France, November 1990) under the aegis of the EEC Concerted Action on PET Investigations of Cellular Regeneration and Degeneration. This book provides a current and comprehensive overview on PET studies of the brain dopamine system which should aid and interest neurologists , psychiatrists, pharmacologists and medical imaging scientists. (author). refs.; figs.; tabs.

  6. Imaging of systemic vasculitis in childhood

    Energy Technology Data Exchange (ETDEWEB)

    Soliman, Magdy [The Hospital for Sick Children, Department of Medical Imaging, Toronto, ON (Canada); Cairo University, Department of Medical Imaging, Cairo (Egypt); Laxer, Ronald; Yeung, Rae [The Hospital for Sick Children, Department of Rheumatology, Toronto, ON (Canada); Manson, David; Doria, Andrea S. [The Hospital for Sick Children, Department of Medical Imaging, Toronto, ON (Canada)

    2015-08-15

    The term ''systemic vasculitis'' encompasses a diverse set of diseases linked by the presence of blood-vessel inflammation that are often associated with critical complications. These diseases are uncommon in childhood and are frequently subjected to a delayed diagnosis. Although the diagnosis and treatment may be similar for adult and childhood systemic vasculitides, the prevalence and classification vary according to the age group under investigation. For example, Kawasaki disease affects children while it is rarely encountered in adults. In 2006, the European League Against Rheumatism (EULAR) and the Pediatric Rheumatology European Society (PReS) proposed a classification system for childhood vasculitis adopting the system devised in the Chapel Hill Consensus Conference in 1993, which categorizes vasculitides according to the predominant size of the involved blood vessels into small, medium and large vessel diseases. Currently, medical imaging has a pivotal role in the diagnosis of vasculitis given recent developments in the imaging of blood vessels. For example, early diagnosis of coronary artery aneurysms, a serious complication of Kawasaki disease, is now possible by magnetic resonance imaging (MRI) of the heart and multidetector computed tomography (MDCT); positron emission tomography/CT (PET/CT) helps to assess active vascular inflammation in Takayasu arteritis. Our review offers a unique approach using the integration of the proposed classification criteria for common systemic childhood vasculitides with their most frequent imaging findings, along with differential diagnoses and an algorithm for diagnosis based on common findings. It should help radiologists and clinicians reach an early diagnosis, therefore facilitating the ultimate goal of proper management of affected children. (orig.)

  7. Imaging of systemic vasculitis in childhood

    International Nuclear Information System (INIS)

    Soliman, Magdy; Laxer, Ronald; Yeung, Rae; Manson, David; Doria, Andrea S.

    2015-01-01

    The term ''systemic vasculitis'' encompasses a diverse set of diseases linked by the presence of blood-vessel inflammation that are often associated with critical complications. These diseases are uncommon in childhood and are frequently subjected to a delayed diagnosis. Although the diagnosis and treatment may be similar for adult and childhood systemic vasculitides, the prevalence and classification vary according to the age group under investigation. For example, Kawasaki disease affects children while it is rarely encountered in adults. In 2006, the European League Against Rheumatism (EULAR) and the Pediatric Rheumatology European Society (PReS) proposed a classification system for childhood vasculitis adopting the system devised in the Chapel Hill Consensus Conference in 1993, which categorizes vasculitides according to the predominant size of the involved blood vessels into small, medium and large vessel diseases. Currently, medical imaging has a pivotal role in the diagnosis of vasculitis given recent developments in the imaging of blood vessels. For example, early diagnosis of coronary artery aneurysms, a serious complication of Kawasaki disease, is now possible by magnetic resonance imaging (MRI) of the heart and multidetector computed tomography (MDCT); positron emission tomography/CT (PET/CT) helps to assess active vascular inflammation in Takayasu arteritis. Our review offers a unique approach using the integration of the proposed classification criteria for common systemic childhood vasculitides with their most frequent imaging findings, along with differential diagnoses and an algorithm for diagnosis based on common findings. It should help radiologists and clinicians reach an early diagnosis, therefore facilitating the ultimate goal of proper management of affected children. (orig.)

  8. Expandable image compression system: A modular approach

    International Nuclear Information System (INIS)

    Ho, B.K.T.; Chan, K.K.; Ishimitsu, Y.; Lo, S.C.; Huang, H.K.

    1987-01-01

    The full-frame bit allocation algorithm for radiological image compression developed in the authors' laboratory can achieve compression ratios as high as 30:1. The software development and clinical evaluation of this algorithm has been completed. It involves two stages of operations: a two-dimensional discrete cosine transform and pixel quantization in the transform space with pixel depth kept accountable by a bit allocation table. Their design took an expandable modular approach based on the VME bus system which has a maximum data transfer rate of 48 Mbytes per second and a Motorola 68020 microprocessor as the master controller. The transform modules are based on advanced digital signal processor (DSP) chips microprogrammed to perform fast cosine transforms. Four DSP's built into a single-board transform module can process an 1K x 1K image in 1.7 seconds. Additional transform modules working in parallel can be added if even greater speeds are desired. The flexibility inherent in the microcode extends the capabilities of the system to incorporate images of variable sizes. Their design allows for a maximum image size of 2K x 2K

  9. Application of gel dosimetry - A preliminary study on verification of uniformity of activity and length of source used in Beta-Cath system

    International Nuclear Information System (INIS)

    Subramaniam, S.; Rabi Raja Singh, I.; Visalatchi, S.; Paul Ravindran, B.

    2002-01-01

    at the middle during gelation of the gel. After the formation of the gel the nylon tube was removed and in its place the intra-coronary catheter was inserted. This was connected to the Betacath equipment and the gels were exposed to a dose of 20Gy with the time of irradiation given by the manufacturers. The T1 weighted MR scan of the irradiated gels shown was obtained for all the three syringes using Philips Gyroscan of 0.5T with TE=20ms, TR=3000ms for a Tl of 500 ms. The images obtained were analyzed with Scion Image (Scion Corporation). The profiles with distance against density values were obtained for the images of the three gels and are shown. It was found that the area of irradiation was clearly visualized in the gel. The length of the irradiated area was measured as 40.3mm on screen and from the profiles, it was measured as 39.64mm. It can be seen that the density is uniform throughout the length of 39.64mm of the irradiated region. Thus the uniformity of activity throughout the source train in the Beta-Cath system was verified with Fricke gel. Even though the diffusion property of the ferric ions in the gel led to a time constraint between irradiation and measurement, we concluded that Fricke gel can be used as a quality assurance tool to verify the uniformity of activity of the source

  10. Multilayer X-ray imaging systems

    Science.gov (United States)

    Shealy, D. L.; Hoover, R. B.; Gabardi, D. R.

    1986-01-01

    An assessment of the imaging properties of multilayer X-ray imaging systems with spherical surfaces has been made. A ray trace analysis was performed to investigate the effects of using spherical substrates (rather than the conventional paraboloidal/hyperboloidal contours) for doubly reflecting Cassegrain telescopes. These investigations were carried out for mirrors designed to operate at selected soft X-ray/XUV wavelengths that are of significance for studies of the solar corona/transition region from the Stanford/MSFC Rocket X-Ray Telescope. The effects of changes in separation of the primary and secondary elements were also investigated. These theoretical results are presented as well as the results of ray trace studies to establish the resolution and vignetting effects as a function of field angle and system parameters.

  11. In-situ Planetary Subsurface Imaging System

    Science.gov (United States)

    Song, W.; Weber, R. C.; Dimech, J. L.; Kedar, S.; Neal, C. R.; Siegler, M.

    2017-12-01

    Geophysical and seismic instruments are considered the most effective tools for studying the detailed global structures of planetary interiors. A planet's interior bears the geochemical markers of its evolutionary history, as well as its present state of activity, which has direct implications to habitability. On Earth, subsurface imaging often involves massive data collection from hundreds to thousands of geophysical sensors (seismic, acoustic, etc) followed by transfer by hard links or wirelessly to a central location for post processing and computing, which will not be possible in planetary environments due to imposed mission constraints on mass, power, and bandwidth. Emerging opportunities for geophysical exploration of the solar system from Venus to the icy Ocean Worlds of Jupiter and Saturn dictate that subsurface imaging of the deep interior will require substantial data reduction and processing in-situ. The Real-time In-situ Subsurface Imaging (RISI) technology is a mesh network that senses and processes geophysical signals. Instead of data collection then post processing, the mesh network performs the distributed data processing and computing in-situ, and generates an evolving 3D subsurface image in real-time that can be transmitted under bandwidth and resource constraints. Seismic imaging algorithms (including traveltime tomography, ambient noise imaging, and microseismic imaging) have been successfully developed and validated using both synthetic and real-world terrestrial seismic data sets. The prototype hardware system has been implemented and can be extended as a general field instrumentation platform tailored specifically for a wide variety of planetary uses, including crustal mapping, ice and ocean structure, and geothermal systems. The team is applying the RISI technology to real off-world seismic datasets. For example, the Lunar Seismic Profiling Experiment (LSPE) deployed during the Apollo 17 Moon mission consisted of four geophone instruments

  12. Development of terahertz systems for imaging applications

    OpenAIRE

    Maestrojuán Biurrun, Itziar

    2016-01-01

    El principal objetivo de esta tesis fue el estudio y desarrollo de tecnología, concretamente mezcladores armónicos, trabajando a frecuencias de milimétricas y sub-milimétricas con el fin de implementar sistemas para aplicaciones de imagen. The main goal of this thesis was the study and development of technology, specifically harmonic mixers, working at millimetre and submillimetre frequencies in other to implement systems for imaging applications. A couple of sub-harmonic...

  13. Laboratory testing & measurement on optical imaging systems

    CSIR Research Space (South Africa)

    Theron, B

    2013-04-01

    Full Text Available on Optical Imaging Systems Bertus Theron 27 April 2013 presented at SIECPC 2013, Riyadh, Saudi Arabia Overview of Workshop Part 1. Introduction & Context  Some history of Arabic Optics  Context: Global vs Local optical testing... of Arabic Optics 1 See [4]  Arabic records of study of geometrical optics  Traced to Hellenistic (Greek) optics  Translated to Arabic  9th century  Arabic contribution to geometric optics  Not just translation to Arabic  Innovative research...

  14. Characterization Of The Alpha/Beta Counting System Type MPC 9400 And Its Utilization

    International Nuclear Information System (INIS)

    Makhsum; Sutarman; Fikri, Hanif; Handoko, Djati

    2000-01-01

    Have been carried out the experiment to determine the operation voltage, instrument stability, counting efficiency, figure of merit, and minimum detectable activity. This instrument used to count gross alpha and gross beta. This instrument belongs good stability at the confidence level of 95 % and the background count that was 0,144 cpm for alpha and 22,65 cpm for beta. The counting efficiency was 27,41 % (electrodeposition of Am-241), 6,57 % (deposition of Am-241), 51,82 % (deposition of Sr-90). The limit of detectable activity was 1,04 x 10 exp.-2 Bq (electrodeposition of Am-241), 4,35 x 10 exp.-2 Bq (% deposition of Sr 90)

  15. GammaCam trademark radiation imaging system

    International Nuclear Information System (INIS)

    1998-02-01

    GammaCam trademark, a gamma-ray imaging system manufactured by AIL System, Inc., would benefit a site that needs to locate radiation sources. It is capable of producing a two-dimensional image of a radiation field superimposed on a black and white visual image. Because the system can be positioned outside the radiologically controlled area, the radiation exposure to personnel is significantly reduced and extensive shielding is not required. This report covers the following topics: technology description; performance; technology applicability and alternatives; cost; regulatory and policy issues; and lessons learned. The demonstration of GammaCam trademark in December 1996 was part of the Large-Scale Demonstration Project (LSDP) whose objective is to select and demonstrate potentially beneficial technologies at the Argonne National Laboratory-East (ANL) Chicago Pile-5 Research Reactor (CP-5). The purpose of the LSDP is to demonstrate that by using innovative and improved decontamination and decommissioning (D and D) technologies from various sources, significant benefits can be achieved when compared to baseline D and D technologies

  16. Defining beta adrenoreceptors in the living heart with iodocyanopindolol

    International Nuclear Information System (INIS)

    Sisson, J.C.; Wieland, D.M.; Koeppe, R.A.; Frey, K.A.; Normolle, D.P.

    1991-01-01

    Beta adrenoreceptors in the heart are integral to the regulation of myocardial function by the sympathetic nervous system and are important in adaptations to physiologic stress and disease. However, these adrenoreceptors have not been defined throughout the living heart. Iodocyanopindolol (ICYP), a nonselective beta antagonist, binds with high affinity to beta adrenoreceptors and, when radiolabeled, offers a method for portraying the receptors quantitatively. When administered intravenously to rats, [ 125 I]ICYP in the heart was fitted with a mathematical model. The T 1/2 of offset of binding from the heart was several hours, and metabolism of ICYP in blood and heart was modest. ICYP in the heart fulfilled the following criteria for binding to beta adrenoreceptors: Patterns of inhibition produced by a beta agonist and beta antagonists were according to dose and potency; binding of (-)ICYP and (±)ICYP were stereospecific; and binding was saturable. When administered intravenously to dogs at 3-5 mCi, [ 123 I]ICYP distributed diffusely in the myocardium, as seen in scintigraphic tomographs of the heart. A small quantity of another beta antagonist selectively reduced lung binding to improve image quality. Thus, [ 123 I]ICYP portrays beta adrenoreceptors in the living heart. With newer detection instruments, dynamic data of [ 123 I]ICYP can be acquired to quantify the adrenoreceptors

  17. Comparison of initial and delayed myocardial imaging with beta-methyl-p-[[sup 123]I]-iodophenylpentadecanoic acid in acute myocardial infarction

    Energy Technology Data Exchange (ETDEWEB)

    Naruse, Hitoshi; Yoshimura, Noriko; Yamamoto, Juro; Morita, Masato; Fukutake, Naoshige; Ohyanagi, Mitsumasa; Iwasaki, Tadaaki; Fukuchi, Minoru (Hyogo Coll. of Medicine, Nishinomiya (Japan))

    Myocardial imaging using [beta]-methyl-p-[[sup 123]I]-iodophenylpentadecanoic acid (BMIPP) of 15 patients with acute myocardial infarction was performed to assess 'fill-in' and 'washout' defects in the delayed myocardial image. The initial and delayed images were evaluated by a visual and quantitative washout rate method. Visual judgement found 8/180 (4%) segments showed 'fill-in' defects, and 24/180 segments (13%) showed 'washout' defects. There was no relationship between days from onset to the study and the frequency of fill-in and washout defects. The mean washout rate in the segments with 'fill-in' defects was 9.0[+-]16.6%, and that of 'washout' defects was 24.9[+-]18.1% which was significantly higher than in controls (8.7[+-]15.4%, p<0.05). There was no correlation between mean washout rate and total blood lipids, total cholesterol, triglyceride and HDL-cholesterol. Therefore, neither time from onset nor blood lipids level was related to changes from the initial image to the delayed image. These changes may be due to relative (false) findings due to changes in circumference, and may be based on myocardial characteristics after myocardial infarction and/or reperfusion. (author).

  18. [Comparison of initial and delayed myocardial imaging with beta-methyl-p-[123I]-iodophenylpentadecanoic acid in acute myocardial infarction].

    Science.gov (United States)

    Naruse, H; Yoshimura, N; Yamamoto, J; Morita, M; Fukutake, N; Ohyanagi, M; Iwasaki, T; Fukuchi, M

    1994-01-01

    Myocardial imaging using beta-methyl-p-[123I]-iodophenylpentadecanoic acid (BMIPP) of 15 patients with acute myocardial infarction was performed to assess "fill-in" and "washout" defects in the delayed myocardial image. The initial and delayed images were evaluated by a visual and quantitative washout rate method. Visual judgement found 8/180 (4%) segments showed "fill-in" defects, and 24/180 segments (13%) showed "washout" defects. There was no relationship between days from onset to the study and the frequency of fill-in and washout defects. The mean washout rate in the segments with "fill-in" defects was 9.0 +/- 16.6%, and that of "washout" defects was 24.9 +/- 18.1% which was significantly higher than in controls (8.7 +/- 15.4%, p < 0.05). There was no correlation between mean washout rate and total blood lipids, total cholesterol, triglyceride and HDL-cholesterol. Therefore, neither time from onset nor blood lipids level was related to changes from the initial image to the delayed image. These changes may be due to relative (false) findings due to changes in circumference, and may be based on myocardial characteristics after myocardial infarction and/or reperfusion.

  19. High beta experiments in CHS

    International Nuclear Information System (INIS)

    Okamura, S.; Matsuoka, K.; Nishimura, K.

    1994-09-01

    High beta experiments were performed in the low-aspect-ratio helical device CHS with the volume-averaged equilibrium beta up to 2.1 %. These values (highest for helical systems) are obtained for high density plasmas in low magnetic field heated with two tangential neutral beams. Confinement improvement given by means of turning off gas puffing helped significantly to make high betas. Magnetic fluctuations increased with increasing beta, but finally stopped to increase in the beta range > 1 %. The coherent modes appearing in the magnetic hill region showed strong dependence on the beta values. The dynamic poloidal field control was applied to suppress the outward plasma movement with the plasma pressure. Such an operation gave fixed boundary operations of high beta plasmas in helical systems. (author)

  20. Brain MR imaging in systemic lupus erythematous

    Energy Technology Data Exchange (ETDEWEB)

    Park, Hyun Ae; Chang, Kee Hyun; Han, Moon Hee; Lee, Kyung Hwon; Kim, Sung Kwon; Lee, Jung Sang [Seoul National University College of Medicine, Seoul (Korea, Republic of); Cha, Sang Hoon [Chungbuk National University College of Medicine, Chungju (Korea, Republic of)

    1992-09-15

    To present MR imaging findings of intracranial lesions in systemic lupus erythematosus(SLE), a retrospective study was performed on MR images of 33 SLE patients with neurologic symptoms and signs. MR imaging was performed on either a 0.5 T (21 patients) or 2.0 T unit (12 patients), using T1-weighted, proton-density-weighted, and T2-weighted spin echo sequences in all patients. In seven patients, post-contrast T1-weighted images were also obtained after administration of gadopentetate dimeglumine. The main MR findings consisted of focal lesions suggesting ischemia/infarct (15 patients), diffuse brain atrophy (8), and findings associated with infection (4). The MR findings were normal in 11 patients (33%). The focal lesions suggesting ischemia/infarcts presumably secondary to vasculitis were distributed in the cortex or subcortical white matter (7 patients), deep periventricular white matter (3), or in both areas (5). Most of the focal lesions were multiple and small in size. The findings associated with infection were variable and included communicating hydrocephalus, meningeal enhancement, granuloma, etc. MR findings of SLE were non-specific and therefore clinical correlation is needed when evaluating SLE in MR.

  1. Expandable image compression system: A modular approach

    International Nuclear Information System (INIS)

    Ho, B.K.T.; Lo, S.C.; Huang, H.K.

    1986-01-01

    The full-frame bit-allocation algorithm for radiological image compression can achieve an acceptable compression ratio as high as 30:1. It involves two stages of operation: a two-dimensional discrete cosine transform and pixel quantization in the transformed space with pixel depth kept accountable by a bit-allocation table. The cosine transform hardware design took an expandable modular approach based on the VME bus system with a maximum data transfer rate of 48 Mbytes/sec and a microprocessor (Motorola 68000 family). The modules are cascadable and microprogrammable to perform 1,024-point butterfly operations. A total of 18 stages would be required for transforming a 1,000 x 1,000 image. Multiplicative constants and addressing sequences are to be software loaded into the parameter buffers of each stage prior to streaming data through the processor stages. The compression rate for 1K x 1K images is expected to be faster than one image per sec

  2. Cine MR imaging of the cardiovascular system

    International Nuclear Information System (INIS)

    Nishimura, Fumiaki; Yoshino, Yasushi; Mihara, Junji; Ichikawa, Seiichi; Kimura, Masahiko; Yano, Masao; Umeda, Masahiro; Oouchi, Toshihiro

    1990-01-01

    In recent years cine magnetic resonance imaging (MRI) has developed as a high-speed imaging technique that provides a high intensity signal even at a short repetition time (20-30 msec) by using an excited pulse with a small flip angle according to the gradient echo method, enabling about 20 to 30 continuous images of the same section per one cardiac cycle to be taken. On cine display of these continuous images, information concerning blood flow shown by a high intensity signal in comparison with that of the myocardium and vascular wall is obtained with high temporal resolution along with anatomical information. The present study reports the clinical usefulness of cine MRI in today's situation, inculding the following: calculation of the left ventricular ejection fraction and pulmonary-to-systemic flow ratio in congenital shunt disease by integration of the area of multisections through application of Simpson's method; diagnosis of the severity of valvular regurgitation, evaluation of stenosal diseases, and diagnosis of inflow from the fissured entry of dissecting aortic aneurysm by evaluating of an area of low intensity signal, probably based on the high velocity or turbulent blood flow: and evaluation of patency of the internal mammary artery bypass graft of the basis of the possible visualization of even thin blood vessels because of the high intensity signal of blood flow. In particular, the characteristics of this procedures are described by comparing it with other technologies in the field of diseases of valvular regurgitation. (author)

  3. Systems for increasing the sensitivity of gamma-ray imagers

    Science.gov (United States)

    Mihailescu, Lucian; Vetter, Kai M.; Chivers, Daniel H.

    2012-12-11

    Systems that increase the position resolution and granularity of double sided segmented semiconductor detectors are provided. These systems increase the imaging resolution capability of such detectors, either used as Compton cameras, or as position sensitive radiation detectors in imagers such as SPECT, PET, coded apertures, multi-pinhole imagers, or other spatial or temporal modulated imagers.

  4. Molecular Imaging with Activatable Reporter Systems

    Directory of Open Access Journals (Sweden)

    Gang Niu, Xiaoyuan Chen

    2012-01-01

    Full Text Available Molecular imaging is a newly emerged multiple disciplinary field that aims to visualize, characterize and quantitatively measure biological processes at cellular and molecular levels in humans and other living systems. A reporter gene is a piece of DNA encoding reporter protein, which presents as a readily measurable phenotype that can be distinguished easily from the background of endogenous protein. After being transferred into cells of organ systems (transgenes, the reporter gene can be utilized to visualize transcriptional and posttranscriptional regulation of gene expression, protein-protein interactions, or trafficking of proteins or cells in living subjects. Herein, we review previous classification of reporter genes and regroup the reporter gene based imaging as basic, inducible and activatable, based on the regulation of reporter gene transcription and post-translational modification of reporter proteins. We then focus on activatable reporters, in which the signal can be activated at the posttranslational level for visualizing protein-protein interactions, protein phosphorylation or tertiary structure changes. The applications of several types of activatable reporters will also be summarized. We conclude that activatable reporter imaging can benefit both basic biomedical research and drug development.

  5. Special feature on imaging systems and techniques

    Science.gov (United States)

    Yang, Wuqiang; Giakos, George

    2013-07-01

    The IEEE International Conference on Imaging Systems and Techniques (IST'2012) was held in Manchester, UK, on 16-17 July 2012. The participants came from 26 countries or regions: Austria, Brazil, Canada, China, Denmark, France, Germany, Greece, India, Iran, Iraq, Italy, Japan, Korea, Latvia, Malaysia, Norway, Poland, Portugal, Sweden, Switzerland, Taiwan, Tunisia, UAE, UK and USA. The technical program of the conference consisted of a series of scientific and technical sessions, exploring physical principles, engineering and applications of new imaging systems and techniques, as reflected by the diversity of the submitted papers. Following a rigorous review process, a total of 123 papers were accepted, and they were organized into 30 oral presentation sessions and a poster session. In addition, six invited keynotes were arranged. The conference not only provided the participants with a unique opportunity to exchange ideas and disseminate research outcomes but also paved a way to establish global collaboration. Following the IST'2012, a total of 55 papers, which were technically extended substantially from their versions in the conference proceeding, were submitted as regular papers to this special feature of Measurement Science and Technology . Following a rigorous reviewing process, 25 papers have been finally accepted for publication in this special feature and they are organized into three categories: (1) industrial tomography, (2) imaging systems and techniques and (3) image processing. These papers not only present the latest developments in the field of imaging systems and techniques but also offer potential solutions to existing problems. We hope that this special feature provides a good reference for researchers who are active in the field and will serve as a catalyst to trigger further research. It has been our great pleasure to be the guest editors of this special feature. We would like to thank the authors for their contributions, without which it would

  6. Effect of cardiopulmonary bypass on beta adrenergic receptor-adenylate cyclase system on surfaces of peripheral lymphocytes.

    Science.gov (United States)

    Luo, A; Tian, Y; Jin, S

    2000-01-01

    The experimental results showed that the level of CAMP, the ratio of cAPM to cGMP, IL-2R expression and IL-2 production in vitro in lymphocytes immediate and 2 weeks after cardiopulmonary bypass (CPB) were significantly lower than those before anesthetics in the patients undergoing cardiac surgery with CPB. These findings suggested that CPB could cause serious damage to adrenergic beta receptor-adenylate cyclase system on circulating lymphocytes surfaces, which might be one of the mechanisms resulting in immunosuppression after open heart surgery with CPB.

  7. Beta spectrometry

    International Nuclear Information System (INIS)

    Dryak, P.; Zderadicka, J.; Plch, J.; Kokta, L.; Novotna, P.

    1977-01-01

    For the purpose of beta spectrometry, a semiconductor spectrometer with one Si(Li) detector cooled with liquid nitrogen was designed. Geometrical detection efficiency is about 10% 4 sr. The achieved resolution for 624 keV conversion electrons of sup(137m)Ba is 2.6 keV (FWHM). A program was written in the FORTRAN language for the correction of the deformation of the measured spectra by backscattering in the analysis of continuous beta spectra. The method permits the determination of the maximum energy of the beta spectrum with an accuracy of +-5 keV. (author)

  8. Space-Ready Advanced Imaging System, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — In this Phase II effort Toyon will increase the state-of-the-art for video/image systems. This will include digital image compression algorithms as well as system...

  9. Comparison of gamma- and beta radiation stress responses on anti-oxidative defense system and DNA modifications in Lemna minor

    Energy Technology Data Exchange (ETDEWEB)

    Van Hoeck, Arne [SCK.CEN, Boeretang 200 2400 Mol (Belgium); University of Antwerp, Groenenborgerlaan 171, 2020 Antwerpen (Belgium); Horemans, Nele; Van Hees, May; Nauts, Robin; Vandenhove, Hildegarde [SCK.CEN, Boeretang 200 2400 Mol (Belgium); Knapen, Dries; Blust, Ronny [University of Antwerp, Groenenborgerlaan 171, 2020 Antwerpen (Belgium)

    2014-07-01

    The biological effects and interactions of different radiation types in plants are still far from understood. Additional knowledge on the impact of various kinds of ionizing radiation in plants on individual, biochemical and molecular level is needed to unravel and compare the toxic mode of action. Among different radiation types, external gamma radiation treatments have been mostly studied both in lab and field studies to derive the biological impact of radiation toxicity in organisms. However, environmental relevant studies on chronic low-dose gamma exposures are scarce. The radio-ecologically relevant radionuclide {sup 90}Sr is a pure beta emitting isotope and originates from nuclear activities and accidents. Although this radionuclide is not essential for plant metabolism, it bears a chemical analogy with the essential plant macro-nutrient Ca{sup 2+} thereby taking advantage of Ca{sup 2+} transport systems to contaminate plant organs and tissues. Ones plants are exposed to radiation stress, ionization events can cause an increase in reactive oxygen species (ROS) and can induce damage to biological material like DNA, lipids and structural proteins. The following work aimed at evaluating individual, biochemical and molecular endpoints to understand and to compare the mode of action of gamma- and beta radiation stress in plants. Having an equal relative biological effectiveness to non-human biota, it is still not clear in how plants differ or overlap in sensing and interpreting highly penetrating electromagnetic radiation with short-range particle radiation. The floating plant Lemna minor was chosen as model system. Following the OECD guidelines Lemna plants were being exposed separately to an external gamma radiation source or to a {sup 90}Sr-contaminated growth medium to obtain single-dose response curves for each type of radiation. In order to acquire accurate dose rate quantifications for beta radiation exposures, {sup 90}Sr uptake and accumulation of root and

  10. An integral design strategy combining optical system and image processing to obtain high resolution images

    Science.gov (United States)

    Wang, Jiaoyang; Wang, Lin; Yang, Ying; Gong, Rui; Shao, Xiaopeng; Liang, Chao; Xu, Jun

    2016-05-01

    In this paper, an integral design that combines optical system with image processing is introduced to obtain high resolution images, and the performance is evaluated and demonstrated. Traditional imaging methods often separate the two technical procedures of optical system design and imaging processing, resulting in the failures in efficient cooperation between the optical and digital elements. Therefore, an innovative approach is presented to combine the merit function during optical design together with the constraint conditions of image processing algorithms. Specifically, an optical imaging system with low resolution is designed to collect the image signals which are indispensable for imaging processing, while the ultimate goal is to obtain high resolution images from the final system. In order to optimize the global performance, the optimization function of ZEMAX software is utilized and the number of optimization cycles is controlled. Then Wiener filter algorithm is adopted to process the image simulation and mean squared error (MSE) is taken as evaluation criterion. The results show that, although the optical figures of merit for the optical imaging systems is not the best, it can provide image signals that are more suitable for image processing. In conclusion. The integral design of optical system and image processing can search out the overall optimal solution which is missed by the traditional design methods. Especially, when designing some complex optical system, this integral design strategy has obvious advantages to simplify structure and reduce cost, as well as to gain high resolution images simultaneously, which has a promising perspective of industrial application.

  11. Use of iodine-123 metaiodobenzylguanidine myocardial imaging to predict the effectiveness of {beta}-blocker therapy in patients with dilated cardiomyopathy

    Energy Technology Data Exchange (ETDEWEB)

    Fukuoka, Shuji [Department of Radiology, National Cardiovascular Center, Osaka (Japan); Hayashida, Kohei [Department of Radiology, National Cardiovascular Center, Osaka (Japan); Hirose, Yoshiaki [Department of Radiology, National Cardiovascular Center, Osaka (Japan); Shimotsu, Yoriko [Department of Radiology, National Cardiovascular Center, Osaka (Japan); Ishida, Yoshio [Department of Radiology, National Cardiovascular Center, Osaka (Japan); Kakuchi, Hiroyuki [Department of Internal Medicine, National Cardiovascular Center, Osaka (Japan); Eto, Tanenao [First Department of Internal Medicine, Miyazaki Medical College, Miyazaki (Japan)

    1997-05-01

    We studied 13 patients with dilated cardiomyopathy (DCM) and seven normal subjects. We obtained myocardial SPET images 15 min and 4 h after administration of {sup 123}I-MIBG (111 MBq). Studies were performed in the patients with DCM before and 1 and 3 months after the administration of metoprolol and in the normal subjects. We calculated the regional {sup 123}I-MIBG washout rate (r-WR) in the SPET image, and the global {sup 123}I-MIBG washout rate (g-WR) and heart-mediastinum activity ratio (H/M) using the anterior planar image. We classified patients into those showing a {>=}5% increase in LV ejection fraction (LVEF) at 3 months compared with LVEF values before the treatment (group I, n=7) and those showing a <5% increase in LVEF (group II, n=6). In normal subjects, the r-WR values in each of the anterior, lateral, septal and inferior segments were significantly lower than those in groups I and II. These values were 18%{+-}9%, 18%{+-}15%, 20%{+-}12% and 21%{+-}15%, respectively. This study demonstrated that with regional assessment {sup 123}I-MIBG SPET imaging can be used to predict the functional improvement of LVEF at 1 month of {beta}-blocker therapy in patients with DCM. (orig./VHE). With 4 figs., 1 tab.

  12. New imaging systems in nuclear medicine

    International Nuclear Information System (INIS)

    1989-01-01

    PCR-I, an analog coded single ring positron tomograph, demonstrates the concepts of analog coding and the utility of high resolution systems. PCR-I, with a resolution of 4.5mm, has been employed in a series of biological studies using small animals that have been highly successful and will lead to clinical application. The emphasis now is turning to even higher sensitivity instruments in order to provide adequate number of events to populate a volume image. For this purpose, we have designed and are constructing PCR-II, a cylindrical analog coded positron tomograph incorporating 12,800 small detectors coded to 1760 phototubes. The increased sensitivity is achieved by recording all events within a cylindrical source that produce annihilation radiation striking any point on the cylindrical detector. PCR-II is projected to have a sensitivity of 1.6 million counts per second for a 20 centimeter diameter sphere uniformly filled with activity at 1 μCi/cm 3 . This system, with a resolution of 3mm, will approach the limits of sensitivity and resolution for positron tomographs. It is our opinion that this system will revolutionize the concept of positron imaging

  13. Beta Blockers

    Science.gov (United States)

    ... may not work as effectively for people of African heritage and older people, especially when taken without ... conditions/high-blood-pressure/in-depth/beta-blockers/ART-20044522 . Mayo Clinic Footer Legal Conditions and Terms ...

  14. The image acquisition system design of floor grinder

    Science.gov (United States)

    Wang, Yang-jiang; Liu, Wei; Liu, Hui-qin

    2018-01-01

    Based on linear CCD, high resolution image real-time acquisition system serves as designing a set of image acquisition system for floor grinder through the calculation of optical imaging system. The entire image acquisition system can collect images of ground before and after the work of the floor grinder, and the data is transmitted through the Bluetooth system to the computer and compared to realize real-time monitoring of its working condition. The system provides technical support for the design of unmanned ground grinders.

  15. Magnetic resonance imaging of the cardiovascular system

    International Nuclear Information System (INIS)

    Masuda, Yoshiaki; Imai, Hiroshi; Watanabe, Sigeru; Inagaki, Yoshiaki; Tateno, Yukio; Ikehira, Hiroo.

    1990-01-01

    Magnetic resonance imaging (MRI) is a new noninvasive technique for visualization of the cardiovascular system, and is used to evaluate tissue characteristics, cardiac function and blood flow abnormalities, as well as to obtain morphological information. In this paper we presented results of clinical and laboratory research obtained using conventional spin echo MRI with regard to cardiovascular anatomy, tissue characterization and physiology. Furthermore, experience with two new techniques, cine-MRI and volume-selected MR spectroscopy, and their potential clinical usefulness in detecting cardiovascular diseases are documented. (author)

  16. GRANITE- A steroscopic imaging Chernkov telescope system

    International Nuclear Information System (INIS)

    Shubnell, M.; Akerlof, C.W.; Cawley, M.F.; Chantell, M.; Fegan, D.J.; Fennell, S.; O'Flaherty, K.S.; Freeman, S.; Frishman, D.; Gaidos, J.A.; Hagan, J.; Harris, K.; Hillas, A.M.; Kerrick, A.D.; Lamb, R.C.; Lappin, T.; Lawrence, M.A.; Levy, H.; Lewis, D.A.; Meyer, D.I.; Mohanty, G.; Punch, M.; Reynolds, P.T.; Rovero, A.C.; Sembroski, G.; Weaverdyck, C.; Weekes, T.C.; Whitaker, T.; Wilson, C.

    1993-01-01

    A second 10 meter class imaging telescope was constructed on Mt. Hopkins, Arizona, the site of the original 10 meter Whipple Cherenkov telescope. The twin telescope system with a 140 meter base line will allow both a reduction in the energy threshold and an improvement in the rejection of the hardonic background. The new telescope started operation in December 1991. With the final completion of the first installation stage (GRANITE I) during spring 92, it is now operating simultaneously with the orginal reflector. We describe in this paper design and construction of the new instrument and demonstrate the capability of the experiment to record coincident events

  17. Primary 4{pi}{beta}-{gamma} coincidence system for standardization of radionuclides by means of plastic scintillators; Sistema primario por coincidencias 4{pi}{beta}-{gamma} para a padronizacao de radionuclideos empregando cintiladores plasticos

    Energy Technology Data Exchange (ETDEWEB)

    Baccarelli, Aida Maria

    2003-07-01

    The present work describes a 4{pi}({alpha},{beta})-{gamma} coincidence system for absolute measurement of radionuclide activity using a plastic scintillator in 4{pi} geometry for charged particles detection and a Nal (Tl) crystal for gamma-ray detection. Several shapes and dimensions of the plastic scintillator have been tried in order to obtain the best system configuration. Radionuclides which decay by alpha emission, {beta}{sup -}, {beta}{sup +} and electron capture have been standardized. The results showed excellent agreement with other conventional primary system which makes use of a 4{pi} proportional counter for X-ray and charged particle detection. The system developed in the present work have some advantages when compared with the conventional systems, namely; it does not need metal coating on the films used as radioactive source holders. When compared to liquid scintillators, is showed the advantage of not needing to be kept in dark for more than 24 h to allow phosphorescence decay of ambient light. Therefore it can be set to count immediately after the sources are placed inside of it. (author)

  18. An Ibm PC/AT-Based Image Acquisition And Processing System For Quantitative Image Analysis

    Science.gov (United States)

    Kim, Yongmin; Alexander, Thomas

    1986-06-01

    In recent years, a large number of applications have been developed for image processing systems in the area of biological imaging. We have already finished the development of a dedicated microcomputer-based image processing and analysis system for quantitative microscopy. The system's primary function has been to facilitate and ultimately automate quantitative image analysis tasks such as the measurement of cellular DNA contents. We have recognized from this development experience, and interaction with system users, biologists and technicians, that the increasingly widespread use of image processing systems, and the development and application of new techniques for utilizing the capabilities of such systems, would generate a need for some kind of inexpensive general purpose image acquisition and processing system specially tailored for the needs of the medical community. We are currently engaged in the development and testing of hardware and software for a fairly high-performance image processing computer system based on a popular personal computer. In this paper, we describe the design and development of this system. Biological image processing computer systems have now reached a level of hardware and software refinement where they could become convenient image analysis tools for biologists. The development of a general purpose image processing system for quantitative image analysis that is inexpensive, flexible, and easy-to-use represents a significant step towards making the microscopic digital image processing techniques more widely applicable not only in a research environment as a biologist's workstation, but also in clinical environments as a diagnostic tool.

  19. Regulation of the cellulolytic system in Trichoderma reesei by sophorose: induction of cellulase and repression of beta-glucosidase.

    OpenAIRE

    Sternberg, D; Mandels, G R

    1980-01-01

    Sophorose has two regulatory roles in the production of cellulase enzymes in Trichoderma reesei: beta-glucosidase repression and cellulase induction. Sophorose also is hydrolyzed by the mycelial-associated beta-glucosidase. Repression of beta-glucosidase reduces sophorose hydrolysis and thus may increase cellulase induction.

  20. Phase equilibria of microemulsion forming system n-decyl-(beta)-D-glucopyranoside/water/n-octane/1-butanol

    DEFF Research Database (Denmark)

    Kahl, Heike; Quitzsch, Konrad; Stenby, Erling Halfdan

    1997-01-01

    of multicomponent system is the coexistence of a highly structural liquid phase enriched with amphiphilic compounds and an excess water or an excess oil phase or both of them. The phase behaviour was studied experimentally by use of turbidity titration and HPLC measurements and theoretically by application...... of the UNIQUAC-equation and the UNIFAC-method. The UNIFAC-method is able to describe the phase behaviour in the quaternary system qualitatively, without fitting parameters. However, by applying the UNIQUAC-method, with adjustable parameters, it was only possible to model the ternary subsystems. The modelling......A systematic investigation of the phase behaviour involving microemulsions is presented with respect to experimental and calculated data for the four-component system n-decyl-(beta)-D-glucopyranoside/water/n-octane/1-butanol and its corresponding ternaries at 25°C. The main feature of this kind...

  1. Image processing system for videotape review

    International Nuclear Information System (INIS)

    Bettendroffer, E.

    1988-01-01

    In a nuclear plant, the areas in which fissile materials are stored or handled, have to be monitored continuously. One method of surveillance is to record pictures of TV cameras with determined time intervals on special video recorders. The 'time lapse' recorded tape is played back at normal speed and an inspector checks visually the pictures. This method requires much manpower and an automated method would be useful. The present report describes an automatic reviewing method based on an image processing system; the system detects scene changes in the picture sequence and stores the reduced data set on a separate video tape. The resulting reduction of reviewing time by inspector is important for surveillance data with few movements

  2. SORIS-A standoff radiation imaging system

    International Nuclear Information System (INIS)

    Zelakiewicz, Scott; Hoctor, Ralph; Ivan, Adrian; Ross, William; Nieters, Edward; Smith, William; McDevitt, Daniel; Wittbrodt, Michael; Milbrath, Brian

    2011-01-01

    The detection of radiological and special nuclear material within the country's borders is a crucial component of the national security network. Being able to detect small amounts of radiological material at large distances is especially important for search applications. To provide this capability General Electric's Research Center has developed, as a part of DNDO's standoff radiation detection system advanced technology demonstration (SORDS-ATD) program, a standoff radiation imaging system (SORIS). This vehicle-based system is capable of detecting weak sources at large distances in relatively short times. To accomplish this, GE has developed a novel coded aperture detector based on commercial components from GE Healthcare. An array of commercial gamma cameras modified to increase the system efficiency and energy range are used as position sensitive detectors. Unlike typical coded aperture systems, however, SORIS employs a non-planar mask and thus does not suffer the typical limitations of partially encoded regions giving it a wide field of view. Source identification is done using both low-statistics anomaly indicators and conventional high-statistics algorithms being developed by Pacific Northwest National Laboratory. The results of scanned areas and threats identified are displayed to the user and overlaid on satellite imagery.

  3. SORIS—A standoff radiation imaging system

    Science.gov (United States)

    Zelakiewicz, Scott; Hoctor, Ralph; Ivan, Adrian; Ross, William; Nieters, Edward; Smith, William; McDevitt, Daniel; Wittbrodt, Michael; Milbrath, Brian

    2011-10-01

    The detection of radiological and special nuclear material within the country's borders is a crucial component of the national security network. Being able to detect small amounts of radiological material at large distances is especially important for search applications. To provide this capability General Electric's Research Center has developed, as a part of DNDO's standoff radiation detection system advanced technology demonstration (SORDS-ATD) program, a standoff radiation imaging system (SORIS). This vehicle-based system is capable of detecting weak sources at large distances in relatively short times. To accomplish this, GE has developed a novel coded aperture detector based on commercial components from GE Healthcare. An array of commercial gamma cameras modified to increase the system efficiency and energy range are used as position sensitive detectors. Unlike typical coded aperture systems, however, SORIS employs a non-planar mask and thus does not suffer the typical limitations of partially encoded regions giving it a wide field of view. Source identification is done using both low-statistics anomaly indicators and conventional high-statistics algorithms being developed by Pacific Northwest National Laboratory. The results of scanned areas and threats identified are displayed to the user and overlaid on satellite imagery.

  4. Selectivity and stoichiometry boosting of beta-cyclodextrin in cationic/anionic surfactant systems: when host-guest equilibrium meets biased aggregation equilibrium.

    Science.gov (United States)

    Jiang, Lingxiang; Yu, Caifang; Deng, Manli; Jin, Changwen; Wang, Yilin; Yan, Yun; Huang, Jianbin

    2010-02-18

    Cationic surfactant/anionic surfactant/beta-CD ternary aqueous systems provide a platform for the coexistence of the host-guest (beta-CD/surfactant) equilibrium and the biased aggregation (monomeric/aggregated surfactants) equilibrium. We report here that the interplay between the two equilibria dominates the systems as follows. (1) The biased aggregation equilibrium imposes an apparent selectivity on the host-guest equilibrium, namely, beta-CD has to always selectively bind the major surfactant (molar fraction > 0.5) even if binding constants of beta-CD to the pair of surfactants are quite similar. (2) In return, the host-guest equilibrium amplifies the bias of the aggregation equilibrium, that is, the selective binding partly removes the major surfactant from the aggregates and leaves the aggregate composition approaching the electroneutral mixing stoichiometry. (3) This composition variation enhances electrostatic attractions between oppositely charged surfactant head groups, thus resulting in less-curved aggregates. In particular, the present apparent host-guest selectivity is of remarkably high values, and the selectivity stems from the bias of the aggregation equilibrium rather than the difference in binding constants. Moreover, beta-CD is defined as a "stoichiometry booster" for the whole class of cationic/anionic surfactant systems, which provides an additional degree of freedom to directly adjust aggregate compositions of the systems. The stoichiometry boosting of the compositions can in turn affect or even determine microstructures and macroproperties of the systems.

  5. Central infusion of leptin improves insulin resistance and suppresses beta-cell function, but not beta-cell mass, primarily through the sympathetic nervous system in a type 2 diabetic rat model.

    Science.gov (United States)

    Park, Sunmin; Ahn, Il Sung; Kim, Da Sol

    2010-06-05

    We investigated whether hypothalamic leptin alters beta-cell function and mass directly via the sympathetic nervous system (SNS) or indirectly as the result of altered insulin resistant states. The 90% pancreatectomized male Sprague Dawley rats had sympathectomy into the pancreas by applying phenol into the descending aorta (SNSX) or its sham operation (Sham). Each group was divided into two sections, receiving either leptin at 300ng/kgbw/h or artificial cerebrospinal fluid (aCSF) via intracerebroventricular (ICV) infusion for 3h as a short-term study. After finishing the infusion study, ICV leptin (3mug/kg bw/day) or ICV aCSF (control) was infused in rats fed 30 energy % fat diets by osmotic pump for 4weeks. At the end of the long-term study, glucose-stimulated insulin secretion and islet morphometry were analyzed. Acute ICV leptin administration in Sham rats, but not in SNSX rats, suppressed the first- and second-phase insulin secretion at hyperglycemic clamp by about 48% compared to the control. Regardless of SNSX, the 4-week administration of ICV leptin improved glucose tolerance during oral glucose tolerance tests and insulin sensitivity at hyperglycemic clamp, compared to the control, while it suppressed second-phase insulin secretion in Sham rats but not in SNSX rats. However, the pancreatic beta-cell area and mass were not affected by leptin and SNSX, though ICV leptin decreased individual beta-cell size and concomitantly increased beta-cell apoptosis in Sham rats. Leptin directly decreases insulin secretion capacity mainly through the activation of SNS without modulating pancreatic beta-cell mass.

  6. A Data Acquisition System for Medical Imaging

    International Nuclear Information System (INIS)

    Abellan, Carlos; Cachemiche, Jean-Pierre; Rethore, Frederic; Morel, Christian

    2013-06-01

    A data acquisition system for medical imaging applications is presented. Developed at CPPM, it provides high performance generic data acquisition and processing capabilities. The DAQ system is based on the PICMG xTCA standard and is composed of 1 up to 10 cards in a single rack, each one with 2 Altera Stratix IV FPGAs and a Fast Mezzanine Connector (FMC). Several mezzanines have been produced, each one with different functionalities. Some examples are: a mezzanine capable of receiving 36 optical fibres with up to 180 Gbps sustained data rates or a mezzanine with 12 x 5 Gbps input links, 12 x 5 Gbps output links and an SFP+ connector for control purposes. Several rack sizes are also available, thus making the system scalable from a one card desktop system useful for development purpose up to a full featured rack mounted DAQ for high end applications. Depending on the application, boards may exchange data at speeds of up to 25.6 Gbps bidirectional sustained rates in a double star topology through back-plane connections. Also, front panel optical fibres can be used when higher rates are required by the application. The system may be controlled by a standard Ethernet connection, thus providing easy integration with control computers and avoiding the need for drivers. Two control systems are foreseen. A Socket connection provides easy interaction with automation software regardless of the operating system used for the control PC. Moreover a web server may run on the Envision cards and provide an easy intuitive user interface. The system and its different components will be introduced. Some preliminary measurements with high speed signal links will be presented as well as the signal conditioning used to allow these rates. (authors)

  7. Triangular SPECT system for 3-D total organ volume imaging: Design concept and preliminary imaging results

    International Nuclear Information System (INIS)

    Lim, C.B.; Anderson, J.; Covic, J.

    1985-01-01

    SPECT systems based on 2-D detectors for projection data collection and filtered back-projection image reconstruction have the potential for true 3-D imaging, providing contiguous slice images in any orientation. Anger camera-based SPECT systems have the natural advantage supporting planar imaging clinical procedures. However, current systems suffer from two drawbacks; poor utilization of emitted photons, and inadequate system design for SPECT. A SPECT system consisting of three rectangular cameras with radial translation would offer the variable cylindrical FOV of 25 cm to 40 cm diameter allowing close detector access to the object. This system would provide optimized imaging for both brain and body organs in terms of sensitivity and resolution. For brain imaging a tight detector triangle with fan beam collimation, matching detector UFOV to the head, allows full 2 π utilization of emitted photons, resulting in >4 times sensitivity increase over the single detector system. Minification of intrinsic detector resolution in fan beam collimation further improves system resolution. For body organ imaging the three detectors with parallel hole collimators, rotating in non-circular orbit, provide both improved resolution and three-fold sensitivity increase. Practical challenges lie in ensuring perfect image overlap from three detectors without resolution degradation and artifact generation in order to benefit from the above improvements. An experimental system has been developed to test the above imaging concept and we have successfully demonstrated the superior image quality of the overlapped images. Design concept will be presented with preliminary imaging results

  8. Quantification of image persistence in a digital angiography system

    International Nuclear Information System (INIS)

    Okkalides, D.P.; Raptou, P.D.

    1993-01-01

    Image persistence, as a characteristic of video imaging systems affecting the quality of fast moving fluoroscopic images, is shown to vary considerably. A simple quantitative method for measuring image persistence in a digital angiography system is presented, together with a series of image intensifier exposure-response curves. For the Saticon tube, used with the Siemens 3VA Digitron, it was found that persistence increased for low exposure rates and may increase to 31% at a 120 ms interval. In addition, a sharp increase in image persistence, from 8.3% to 33%, was observed within 18 months from installation of the system. (author)

  9. The grand partition function Z ({alpha},{beta}) of a quantum system is studied, using diagrammatic representations of the perturbation expansion; La grande fonction de partition Z ({alpha},{beta}) d'un systeme quantique est etudies en utilisant des representations diagrammatiques du developpement en serie des perturbations

    Energy Technology Data Exchange (ETDEWEB)

    Dominicis, C. de [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1961-07-01

    The grand partition function Z ({alpha},{beta}) of a quantum system is studied, using diagrammatic representations of the perturbation expansion. For a fermions system, it is possible to show, by proper resummation, without approximations but under some 'regularity hypothesis', that Log Z ({alpha},{beta}) takes a form where, besides trivial dependences, {alpha} and {beta} only appear through a statistical factor F{sub k}{sup -} = [1 + e{sup -{alpha}}{sup +{beta}}{sup {epsilon}{sub k}{sup 0}}{sup -{beta}}{sup W{sub k}}]{sup -1}. W{sub k} is a (real) self-consistent potential, generalized to all orders and can be defined by a stationary condition on Log Z ({alpha},{beta}) under variations of F{sub k}{sup -}. The thermodynamical quantities take a form analogous to the expressions Landau introduced for the Fermi liquids. The zero temperature limit (for isotropic systems) gives back Goldstone expressions for the ground state of a system. (author) [French] La grande fonction de partition Z ({alpha},{beta}) d'un systeme quantique est etudiee en utilisant des representations diagrammatiques du developpement en serie des perturbations. Pour un systeme de fermions on peut, par des resommations adequates, sans approximations mais sous reserve d'une 'hypothese de regularite', mettre Log Z ({alpha},{beta}) sous une forme ou, en dehors de dependances triviales, {alpha} et {beta} n'interviennent que par l'intermediaire d'un facteur statistique F{sub k}{sup -} = [1 + e{sup -{alpha}}{sup +{beta}}{sup {epsilon}{sub k}{sup 0}}{sup -{beta}}{sup W{sub k}}]{sup -1}. W{sub k} est ici un potentiel self-consistant (reel) generalise a tous les ordres et peut etre defini par une condition de stationnarite de Log Z ({alpha},{beta}) pour des variations de F{sub k}{sup -}. Les grandeurs thermodynamiques prennent une forme analogue aux expressions que LANDAU a introduites pour les liquides de FERMI. A la limite de la temperature nulle (et pour un

  10. The grand partition function Z ({alpha},{beta}) of a quantum system is studied, using diagrammatic representations of the perturbation expansion; La grande fonction de partition Z ({alpha},{beta}) d'un systeme quantique est etudies en utilisant des representations diagrammatiques du developpement en serie des perturbations

    Energy Technology Data Exchange (ETDEWEB)

    Dominicis, C de [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1961-07-01

    The grand partition function Z ({alpha},{beta}) of a quantum system is studied, using diagrammatic representations of the perturbation expansion. For a fermions system, it is possible to show, by proper resummation, without approximations but under some 'regularity hypothesis', that Log Z ({alpha},{beta}) takes a form where, besides trivial dependences, {alpha} and {beta} only appear through a statistical factor F{sub k}{sup -} = [1 + e{sup -{alpha}}{sup +{beta}}{sup {epsilon}{sub k}{sup 0}}{sup -{beta}}{sup W{sub k}}]{sup -1}. W{sub k} is a (real) self-consistent potential, generalized to all orders and can be defined by a stationary condition on Log Z ({alpha},{beta}) under variations of F{sub k}{sup -}. The thermodynamical quantities take a form analogous to the expressions Landau introduced for the Fermi liquids. The zero temperature limit (for isotropic systems) gives back Goldstone expressions for the ground state of a system. (author) [French] La grande fonction de partition Z ({alpha},{beta}) d'un systeme quantique est etudiee en utilisant des representations diagrammatiques du developpement en serie des perturbations. Pour un systeme de fermions on peut, par des resommations adequates, sans approximations mais sous reserve d'une 'hypothese de regularite', mettre Log Z ({alpha},{beta}) sous une forme ou, en dehors de dependances triviales, {alpha} et {beta} n'interviennent que par l'intermediaire d'un facteur statistique F{sub k}{sup -} = [1 + e{sup -{alpha}}{sup +{beta}}{sup {epsilon}{sub k}{sup 0}}{sup -{beta}}{sup W{sub k}}]{sup -1}. W{sub k} est ici un potentiel self-consistant (reel) generalise a tous les ordres et peut etre defini par une condition de stationnarite de Log Z ({alpha},{beta}) pour des variations de F{sub k}{sup -}. Les grandeurs thermodynamiques prennent une forme analogue aux expressions que LANDAU a introduites pour les liquides de FERMI. A la limite de la temperature nulle (et pour un systeme isotrope) on retrouve terme a terme les

  11. Non-invasive phenotyping and drug testing in single cardiomyocytes or beta-cells by calcium imaging and optogenetics.

    Directory of Open Access Journals (Sweden)

    Yu-Fen Chang

    Full Text Available Identification of drug induced electrical instability of the heart curtails development, and introduction, of potentially proarrhythmic drugs. This problem usually requires complimentary contact based approaches such as patch-clamp electrophysiology combined with field stimulation electrodes to observe and control the cell. This produces data with high signal to noise but requires direct physical contact generally preventing high-throughput, or prolonged, phenotyping of single cells or tissues. Combining genetically encoded optogenetic control and spectrally compatible calcium indicator tools into a single adenoviral vector allows the analogous capability for cell control with simultaneous cellular phenotyping without the need for contact. This combination can be applied to single rodent primary adult cardiomyocytes, and human stem cell derived cardiomyocytes, enabling contactless small molecule evaluation for inhibitors of sodium, potassium and calcium channels suggesting it may be useful for early toxicity work. In pancreatic beta-cells it reveals the effects of glucose and the KATP inhibitor gliclazide.

  12. Automatic analysis algorithm for radionuclide pulse-height data from beta-gamma coincidence systems

    International Nuclear Information System (INIS)

    Foltz Biegalski, K.M.

    2001-01-01

    There are two acceptable noble gas monitoring measurement modes for Comprehensive Nuclear-Test-Ban-Treaty (CTBT) verification purposes defined in CTBT/PC/II/WG.B/1. These include beta-gamma coincidence and high-resolution gamma-spectrometry. There are at present no commercial, off-the-shelf (COTS) applications for the analysis of β-γ coincidence data. Development of such software is in progress at the Prototype International Data Centre (PIDC) for eventual deployment at the International Data Centre (IDC). Flowcharts detailing the automatic analysis algorithm for β-γ coincidence data to be coded at the PIDC is included. The program is being written in C with Oracle databasing capabilities. (author)

  13. Direct ion storage dosimetry systems for photon, beta and neutron radiation with instant readout capabilities

    International Nuclear Information System (INIS)

    Wernli, C.; Kahilainen, J.

    2001-01-01

    The direct ion storage (DIS) dosemeter is a new type of electronic dosemeter from which the dose information for both H p (10) and H p (0.07) can be obtained instantly at the workplace by using an electronic reader unit. The number of readouts is unlimited and the stored information is not affected by the readout procedure. The accumulated dose can also be electronically reset by authorised personnel. The DIS dosemeter represents a potential alternative for replacing the existing film and thermoluminescence dosemeters (TLDs) used in occupational monitoring due to its ease of use and low operating costs. The standard version for normal photon and beta dosimetry, as well as a developmental version for neutron dosimetry, have been characterised in several field studies. Two new small size variations are also introduced including a contactless readout device and a militarised version optimised for field use. (author)

  14. Beta measurement evaluation and upgrade

    International Nuclear Information System (INIS)

    Swinth, K.L.; Rathbun, L.A.; Roberson, P.L.; Endres, G.W.R.

    1986-01-01

    This program focuses on the resolution of problems associated with the field measurement of the beta dose component at Department of Energy (DOE) facilities. The change in DOE programs, including increased efforts in improved waste management and decontamination and decommissioning (D and D) of facilities, coupled with beta measurement problems identified at Three Mile Island has increased the need to improve beta measurements. In FY 1982, work was initiated to provide a continuing effort to identify problems associated with beta dose assessment at DOE facilities. The problems identified resulted in the development of this program. The investigation includes (1) an assessment of measurement systems now in use, (2) development of improved calibration systems and procedures, (3) application of innovative beta dosimetry concepts, (4) investigation of new instruments or concepts for monitoring and spectroscopy, and (5) development of recommendations to assure an adequate beta measurement program within DOE facilities

  15. Comparison of {sup 11}C-PiB and {sup 18}F-florbetaben for A{beta} imaging in ageing and Alzheimer's disease

    Energy Technology Data Exchange (ETDEWEB)

    Villemagne, Victor L. [Austin Health, Department of Nuclear Medicine and Centre for PET, Heidelberg, VIC (Australia); University of Melbourne, Department of Medicine, Parkville, VIC (Australia); The Mental Health Research Institute of Victoria, Parkville, VIC (Australia); Mulligan, Rachel S.; Pejoska, Svetlana; Ong, Kevin; Jones, Gareth; O' Keefe, Graeme; Chan, J.G.; Young, Kenneth; Tochon-Danguy, Henri [Austin Health, Department of Nuclear Medicine and Centre for PET, Heidelberg, VIC (Australia); Masters, Colin L. [The Mental Health Research Institute of Victoria, Parkville, VIC (Australia); Rowe, Christopher C. [Austin Health, Department of Nuclear Medicine and Centre for PET, Heidelberg, VIC (Australia); University of Melbourne, Department of Medicine, Parkville, VIC (Australia)

    2012-06-15

    Amyloid imaging with {sup 18}F-labelled radiotracers will allow widespread use of this technique, facilitating research, diagnosis and therapeutic development for Alzheimer's disease (AD). The purpose of this analysis was to compare data on cortical A{beta} deposition in subjects who had undergone both {sup 11}C-PiB (PiB) and {sup 18}F-florbetaben (FBB) PET imaging. We identified ten healthy elderly controls (HC) and ten patients with AD who had undergone PET imaging after intravenous injection of 370 MBq of PiB and 300 MBq of FBB under separate research protocols. PiB and FBB images were coregistered so that placement of regions of interest was identical on both scans and standard uptake value ratios (SUVR) using the cerebellar cortex as reference region were calculated between 40 and 70 min and between 90 and 110 min after injection for PiB and FBB, respectively. Significantly higher SUVR values (p < 0.0001) in most cortical areas were observed in AD patients when compared with HC with both radiotracers. Global SUVR values in AD patients were on average 75% higher than in HC with PiB and 56% higher with FBB. There was an excellent linear correlation between PiB and FBB global SUVR values (r = 0.97, p < 0.0001) with similar effect sizes for distinguishing AD from HC subjects for both radiotracers (Cohen's d 3.3 for PiB and 3.0 for FBB). FBB, while having a narrower dynamic range than PiB, clearly distinguished HC from AD patients, with a comparable effect size. FBB seems a suitable {sup 18}F radiotracer for imaging AD pathology in vivo. (orig.)

  16. Millimeter-wave Imaging Systems with Aperture Synthesis Techniques

    DEFF Research Database (Denmark)

    Löffler, Torsten; Krozer, Viktor; Zhurbenko, Vitaliy

    2010-01-01

    The paper describes development of a millimetre-wave imaging system using multi-element aperture filling techniques [1]. Such imaging systems are increasingly demonstrated for security applications and in particular standoff imaging of persons and bonding flaw and defect detection [2]. The major ...

  17. Prototype of Microwave Imaging System for Breast-Cancer Screening

    DEFF Research Database (Denmark)

    Rubæk, Tonny; Zhurbenko, Vitaliy

    2009-01-01

    Microwave imaging for breast-cancer detection has received the attention of a large number of research groups in the last decade. In this paper, the imaging system currently being developed at the Technical university of Denmark is presented. This includes a description of the antenna system......, the microwave hardware, and the imaging algorithm....

  18. Recent developments of MR imaging system and future trends

    International Nuclear Information System (INIS)

    Fujieda, Kunimi

    1996-01-01

    Because MR imaging technique has no limitation of slice direction, uses none of mechanically moving components and can employ electronic scanning method for data acquisition, the most advanced electronics and CPU techniques have been applied to develop MR imaging systems. Along with pursuance of better equipment performance as clinical diagnostic equipment, cost reduction, improvement of operability and safety, easy siting, comfortable examination and economical operation cost by remarkable reduction of running cost have become important factors in development of MR imaging system. From this viewpoint, MR imaging systems incorporating an open gantry with a relatively low field strength and of vertical field system have been developed recently and they are being accepted as clinically useful equipment. The vertical field, open gantry system has an optimum structure capable of performing interventional imaging, thus clinical application of the system have been actively attempted. Thanks to recent development of various MRI techniques, image quality quite acceptable for routine clinical diagnosis can now be obtained by using the systems with permanent magnet and resistive magnet. Thus, it is considered that evaluation of not only equipment performance but also the total performances of the MR imaging system as described above will become important. The MR imaging technique has a possibility to substitute itself for other conventional imaging modalities because the technique can visualize physiological and metabolic functions in addition to morphological imaging. It is expected that application of MR imaging modality will be further expanded by continuous investigation of applicable clinical fields and development of imaging technologies. (J.P.N.)

  19. Intracranial Extramedullary Hematopoiesis in Beta-Thalassemia

    International Nuclear Information System (INIS)

    Karki, Bivek; Xu, Yi Kai; Wu, Yuan Kui; Tamrakar, Karuna

    2012-01-01

    Extramedullary hematopoiesis (EMH) represents tumor-like proliferation of hemopoietic tissue which complicates chronic hemoglobinopathy. Intracranial EMH is an extremely rare occurrence. Magnetic resonance imaging (MRI) offers a precise diagnosis. It is essential to distinguish EMH from other extradural central nervous system tumors, because treatment and prognosis are totally different. Herein, we report the imaging findings of beta-thalassemia in a 13-year-old boy complaining of weakness of left side of the body and gait disturbance; CT and MRI revealed an extradural mass in the right temporoparietal region.

  20. Intracranial extramedullary hematopoiesis in beta-thalassemia.

    Science.gov (United States)

    Karki, Bivek; Xu, Yi-Kai; Tamrakar, Karuna; Wu, Yuan-Kui

    2012-01-01

    Extramedullary hematopoiesis (EMH) represents tumor-like proliferation of hemopoietic tissue which complicates chronic hemoglobinopathy. Intracranial EMH is an extremely rare occurrence. Magnetic resonance imaging (MRI) offers a precise diagnosis. It is essential to distinguish EMH from other extradural central nervous system tumors, because treatment and prognosis are totally different. Herein, we report the imaging findings of beta-thalassemia in a 13-year-old boy complaining of weakness of left side of the body and gait disturbance; CT and MRI revealed an extradural mass in the right temporoparietal region.

  1. Intracranial Extramedullary Hematopoiesis in Beta-Thalassemia

    Energy Technology Data Exchange (ETDEWEB)

    Karki, Bivek; Xu, Yi Kai; Wu, Yuan Kui [Nan fang Hospital, Southern Medical University, Guangzhou (China); Tamrakar, Karuna [Zhujiang Hospital, Southern Medical University, Guangzhou (China)

    2012-03-15

    Extramedullary hematopoiesis (EMH) represents tumor-like proliferation of hemopoietic tissue which complicates chronic hemoglobinopathy. Intracranial EMH is an extremely rare occurrence. Magnetic resonance imaging (MRI) offers a precise diagnosis. It is essential to distinguish EMH from other extradural central nervous system tumors, because treatment and prognosis are totally different. Herein, we report the imaging findings of beta-thalassemia in a 13-year-old boy complaining of weakness of left side of the body and gait disturbance; CT and MRI revealed an extradural mass in the right temporoparietal region.

  2. beta Phase Growth and Precipitation in the 5xxx Series Aluminum Alloy System

    Science.gov (United States)

    Scotto D'Antuono, Daniel

    The 5xxx series aluminum alloys are commonly used for structural applications due to their high strength to weight ratio, corrosion resistance, and weldability. This material system is a non-heat treatable aluminum and derives its strength from a super saturation of magnesium (3%>), and from cold rolling. While these materials have many admiral properties, they can undergo a process known as sensitization when exposed to elevated temperatures (50-280°C) for extended periods of time. During this process, magnesium segregates toward the grain boundaries and forms the secondary precipitate β phase (Al3Mg2). When exposed to harsh environments such as sea water, a galvanic couple is formed between the Al matrix and the β phase precipitates. The precipitates become anodic to the matrix and preferentially dissolve leaving gaps along the boundary network, ultimately leading to stress corrosion cracking. While this problem has been known to occur for some time now, questions relating to nucleation sites, misorientation dependence, effect of prior strain, and preferred temperature regimes remain unanswered. The work contained in this thesis attempted to better understand the kinetics, growth, and misorientation dependence, of β phase precipitation using in situ transmission electron microscopy experiments which allowed for direct visualization of the precipitation process. Orientation imaging using a Nanomegas/ASTAR system (OIM in TEM) coupled with the in situ experiments, along with elemental STEM EELs mapping were used to better understand the diffusion of Mg and found low angle boundaries as potential sites for nucleation. The resulting STEM EELs experiments also showed that Mg is much more stable at the grain boundaries than previously thought. Concurrent bulk ex-situ studies were used to compare various heat treatments, as well as to failed in service material showing that the low temperature treatments yield the metastable β’ phase more readily than the

  3. Real-time beam profile imaging system for actinotherapy accelerator

    International Nuclear Information System (INIS)

    Lin Yong; Wang Jingjin; Song Zheng; Zheng Putang; Wang Jianguo

    2003-01-01

    This paper describes a real-time beam profile imaging system for actinotheraphy accelerator. With the flash X-ray imager and the technique of digital image processing, a real-time 3-dimension dosage image is created from the intensity profile of the accelerator beam in real time. This system helps to obtain all the physical characters of the beam in any section plane, such as FWHM, penumbra, peak value, symmetry and homogeneity. This system has been used to acquire a 3-dimension dosage distribution of dynamic wedge modulator and the transient process of beam dosage. The system configure and the tested beam profile images are also presented

  4. IMIS: An intelligence microscope imaging system

    Science.gov (United States)

    Caputo, Michael; Hunter, Norwood; Taylor, Gerald

    1994-01-01

    Until recently microscope users in space relied on traditional microscopy techniques that required manual operation of the microscope and recording of observations in the form of written notes, drawings, or photographs. This method was time consuming and required the return of film and drawings from space for analysis. No real-time data analysis was possible. Advances in digital and video technologies along with recent developments in article intelligence will allow future space microscopists to have a choice of three additional modes of microscopy: remote coaching, remote control, and automation. Remote coaching requires manual operations of the microscope with instructions given by two-way audio/video transmission during critical phases of the experiment. When using the remote mode of microscopy, the Principal Investigator controls the microscope from the ground. The automated mode employs artificial intelligence to control microscope functions and is the only mode that can be operated in the other three modes as well. The purpose of this presentation is to discuss the advantages and disadvantages of the four modes of of microscopy and how the IMIS, a proposed intelligent microscope imaging system, can be used as a model for developing and testing concepts, operating procedures, and equipment design of specifications required to provide a comprehensive microscopy/imaging capability onboard Space Station Freedom.

  5. Imaging findings in a child with calcineurin inhibitor-induced pain syndrome after bone marrow transplant for beta thalassemia major

    International Nuclear Information System (INIS)

    Ayyala, Rama S.; Arnold, Staci D.; Bhatia, Monica; Dastgir, Jahannaz

    2016-01-01

    Calcineurin inhibitor-induced pain syndrome is an entity recognized in patients on immunosuppressive therapy after transplantation. Diagnosis is characterized by onset of pain beginning in the setting of an elevated calcineurin-inhibitor trough level. Reducing the medication dose relieves symptoms. Imaging findings can be nonspecific, including bone marrow edema and periosteal reaction. We present the unique case of calcineurin inhibitor-induced pain syndrome in a child and review the imaging findings. (orig.)

  6. Imaging findings in a child with calcineurin inhibitor-induced pain syndrome after bone marrow transplant for beta thalassemia major

    Energy Technology Data Exchange (ETDEWEB)

    Ayyala, Rama S.; Arnold, Staci D.; Bhatia, Monica; Dastgir, Jahannaz [Columbia University Medical Center, Morgan Stanley Children' s Hospital, Department of Radiology, New York, NY (United States)

    2016-10-15

    Calcineurin inhibitor-induced pain syndrome is an entity recognized in patients on immunosuppressive therapy after transplantation. Diagnosis is characterized by onset of pain beginning in the setting of an elevated calcineurin-inhibitor trough level. Reducing the medication dose relieves symptoms. Imaging findings can be nonspecific, including bone marrow edema and periosteal reaction. We present the unique case of calcineurin inhibitor-induced pain syndrome in a child and review the imaging findings. (orig.)

  7. PET imaging of alpha(v)beta(3) integrin expression in tumours with Ga-68-labelled mono-, di- and tetrameric RGD peptides

    NARCIS (Netherlands)

    Dijkgraaf, Ingrid; Yim, Cheng-Bin; Franssen, Gerben M.; Schuit, Robert C.; Luurtsema, Gert; Liu, Shuang; Oyen, Wim J. G.; Boerman, Otto C.

    Due to the restricted expression of alpha(v)beta(3) in tumours, alpha(v)beta(3) is considered a suitable receptor for tumour targeting. In this study the alpha(v)beta(3)-binding characteristics of Ga-68-labelled monomeric, dimeric and tetrameric RGD peptides were determined and compared with their

  8. Data acquisition system for radiographic imaging

    International Nuclear Information System (INIS)

    Lanza, R.C.; Votano, J.R.; Russ, T.

    1992-01-01

    This patent describes a continuous data acquisition system for radiographic imaging without interrupting acquisition activity the acquisition system. It comprises at least two memory means for storing radiographic data from a radiation detector wherein each of the memory means having a plurality of addressable memory locations and each of the memory means are such that the locations of the memory means correspond to spatial locations in the radiation detector; logic control means for sensing radiographic data transmitted by the radiation detector, for selecting one of the memory means for storage of the data, for transferring data to the selected memory means, and for switching form one memory means to another memory means according to a predefined schedule and according to memory capacity level, the logic control means further comprising a logic device which receives data and increments the contents of locations in a memory means in response to such data; and interface control means for reading data from one or the other memory means when such memory means is not actively acquiring data such that data can be acquired continuously by the system

  9. Automatic system for detecting pornographic images

    Science.gov (United States)

    Ho, Kevin I. C.; Chen, Tung-Shou; Ho, Jun-Der

    2002-09-01

    Due to the dramatic growth of network and multimedia technology, people can more easily get variant information by using Internet. Unfortunately, it also makes the diffusion of illegal and harmful content much easier. So, it becomes an important topic for the Internet society to protect and safeguard Internet users from these content that may be encountered while surfing on the Net, especially children. Among these content, porno graphs cause more serious harm. Therefore, in this study, we propose an automatic system to detect still colour porno graphs. Starting from this result, we plan to develop an automatic system to search porno graphs or to filter porno graphs. Almost all the porno graphs possess one common characteristic that is the ratio of the size of skin region and non-skin region is high. Based on this characteristic, our system first converts the colour space from RGB colour space to HSV colour space so as to segment all the possible skin-colour regions from scene background. We also apply the texture analysis on the selected skin-colour regions to separate the skin regions from non-skin regions. Then, we try to group the adjacent pixels located in skin regions. If the ratio is over a given threshold, we can tell if the given image is a possible porno graph. Based on our experiment, less than 10% of non-porno graphs are classified as pornography, and over 80% of the most harmful porno graphs are classified correctly.

  10. Radioprotective action of beta-carotin and vitamin A, C and E complexes at reproductive system and indices of antioxidant system in male rat blood and liver

    International Nuclear Information System (INIS)

    Vereshchako, G.G.; Konoplya, E.F.; Khodosovskaya, A.M.; Rutkovskaya, Zh.A.

    2008-01-01

    Effects of total irradiation in low dose at the state of rat mail reproductive system, lipid peroxidation processes and antioxidant system in rat blood and liver tissues as well as radioprotective capacity of beta-carotin with vitamin A, C and E complexes were investigated. It was established that injection of this substances to rat's organism one day before irradiation in 1.0 Gy dose led to normalization of spermatogenic cells number, increase of nucleic acids content in testes and significant improvement of antioxidant status of blood and liver tissue. (authors)

  11. PC imaging system for reactor NDE

    International Nuclear Information System (INIS)

    Anon.

    1987-01-01

    PC-based systems have been given recent attention by EPRI to organize and manage inspection data (RP-2405-15, TestPro system); integrate with larger, mainframe computers to maintain dialogue for on-site and remote applications; and, in this project, to aid the operator in providing guidance to render decisions on the data. The PC system configuration for this project consisted of a central processing unit (CPU), a hard disk and a floppy disk, 640K bytes of system memory, a high-resolution graphics card and compatible color monitor, and a mouse for operator interaction with software. The software package was written in FORTRAN under the PC Disk Operating System (PC-DOS) and utilized a graphics package for image display. Application of this package to crack-counterbore discrimination in piping welds was investigated. Present automatic techniques utilize signal features from single, A-scan data to render a decision on whether the reflector is benign (i.e., counterbore, weld root) or a crack. However, experienced manual operators in the field make reliable decisions based on the integrated response from the reflector as the transducer is scanned past the suspicious region. Since this software package could display and manipulate ensemble A-scans, spatial features - similar to those used by experts - were developed as discriminants. Ultrasonic responses from intergranular stress corrosion cracks (IGSCCs) were discovered to vary both in time-of-flight and in their amplitude, whereas counterbore responses were more consistent. The software package contains methods for viewing and quantifying these spatial features

  12. An integrated compact airborne multispectral imaging system using embedded computer

    Science.gov (United States)

    Zhang, Yuedong; Wang, Li; Zhang, Xuguo

    2015-08-01

    An integrated compact airborne multispectral imaging system using embedded computer based control system was developed for small aircraft multispectral imaging application. The multispectral imaging system integrates CMOS camera, filter wheel with eight filters, two-axis stabilized platform, miniature POS (position and orientation system) and embedded computer. The embedded computer has excellent universality and expansibility, and has advantages in volume and weight for airborne platform, so it can meet the requirements of control system of the integrated airborne multispectral imaging system. The embedded computer controls the camera parameters setting, filter wheel and stabilized platform working, image and POS data acquisition, and stores the image and data. The airborne multispectral imaging system can connect peripheral device use the ports of the embedded computer, so the system operation and the stored image data management are easy. This airborne multispectral imaging system has advantages of small volume, multi-function, and good expansibility. The imaging experiment results show that this system has potential for multispectral remote sensing in applications such as resource investigation and environmental monitoring.

  13. Low background and high contrast PET imaging of amyloid-{beta} with [{sup 11}C]AZD2995 and [{sup 11}C]AZD2184 in Alzheimer's disease patients

    Energy Technology Data Exchange (ETDEWEB)

    Forsberg, Anton; Andersson, Jan; Varnaes, Katarina; Halldin, Christer [Karolinska Institutet, Centre for Psychiatry Research, Department of Clinical Neuroscience, Stockholm (Sweden); Jureus, Anders; Swahn, Britt-Marie; Sandell, Johan; Julin, Per; Svensson, Samuel [AstraZeneca Research and Development, Neuroscience Research and Therapy Area, Soedertaelje (Sweden); Cselenyi, Zsolt; Schou, Magnus; Johnstroem, Peter; Farde, Lars [Karolinska Institutet, Centre for Psychiatry Research, Department of Clinical Neuroscience, Stockholm (Sweden); Karolinska Hospital, AstraZeneca Translational Sciences Centre, PET CoE, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm (Sweden); Eriksdotter, Maria; Freund-Levi, Yvonne [Karolinska Institutet, Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Stockholm (Sweden); Karolinska University Hospital, Department of Geriatric Medicine, Stockholm (Sweden); Jeppsson, Fredrik [AstraZeneca Research and Development, Neuroscience Research and Therapy Area, Soedertaelje (Sweden); Karolinska Institutet, Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Stockholm (Sweden)

    2013-04-15

    The aim of this study was to evaluate AZD2995 side by side with AZD2184 as novel PET radioligands for imaging of amyloid-{beta} in Alzheimer's disease (AD). In vitro binding of tritium-labelled AZD2995 and AZD2184 was studied and compared with that of the established amyloid-{beta} PET radioligand PIB. Subsequently, a first-in-human in vivo PET study was performed using [{sup 11}C]AZD2995 and [{sup 11}C]AZD2184 in three healthy control subjects and seven AD patients. AZD2995, AZD2184 and PIB were found to share the same binding site to amyloid-{beta}. [{sup 3}H]AZD2995 had the highest signal-to-background ratio in brain tissue from patients with AD as well as in transgenic mice. However, [{sup 11}C]AZD2184 had superior imaging properties in PET, as shown by larger effect sizes comparing binding potential values in cortical regions of AD patients and healthy controls. Nevertheless, probably due to a lower amount of nonspecific binding, the group separation of the distribution volume ratio values of [{sup 11}C]AZD2995 was greater in areas with lower amyloid-{beta} load, e.g. the hippocampus. Both AZD2995 and AZD2184 detect amyloid-{beta} with high affinity and specificity and also display a lower degree of nonspecific binding than that reported for PIB. Overall [{sup 11}C]AZD2184 seems to be an amyloid-{beta} radioligand with higher uptake and better group separation when compared to [{sup 11}C]AZD2995. However, the very low nonspecific binding of [{sup 11}C]AZD2995 makes this radioligand potentially interesting as a tool to study minute levels of amyloid-{beta}. This sensitivity may be important in investigating, for example, early prodromal stages of AD or in the longitudinal study of a disease modifying therapy. (orig.)

  14. Multi region based image retrieval system

    Indian Academy of Sciences (India)

    data mining, information theory, statistics and psychology. ∗ .... ground complication and independent of image size and orientation (Zhang 2007). ..... Figure 2. Significant regions: (a) the input image, (b) the primary significant region, (c) the ...

  15. Content Based Retrieval System for Magnetic Resonance Images

    International Nuclear Information System (INIS)

    Trojachanets, Katarina

    2010-01-01

    The amount of medical images is continuously increasing as a consequence of the constant growth and development of techniques for digital image acquisition. Manual annotation and description of each image is impractical, expensive and time consuming approach. Moreover, it is an imprecise and insufficient way for describing all information stored in medical images. This induces the necessity for developing efficient image storage, annotation and retrieval systems. Content based image retrieval (CBIR) emerges as an efficient approach for digital image retrieval from large databases. It includes two phases. In the first phase, the visual content of the image is analyzed and the feature extraction process is performed. An appropriate descriptor, namely, feature vector is then associated with each image. These descriptors are used in the second phase, i.e. the retrieval process. With the aim to improve the efficiency and precision of the content based image retrieval systems, feature extraction and automatic image annotation techniques are subject of continuous researches and development. Including the classification techniques in the retrieval process enables automatic image annotation in an existing CBIR system. It contributes to more efficient and easier image organization in the system.Applying content based retrieval in the field of magnetic resonance is a big challenge. Magnetic resonance imaging is an image based diagnostic technique which is widely used in medical environment. According to this, the number of magnetic resonance images is enormously growing. Magnetic resonance images provide plentiful medical information, high resolution and specific nature. Thus, the capability of CBIR systems for image retrieval from large database is of great importance for efficient analysis of this kind of images. The aim of this thesis is to propose content based retrieval system architecture for magnetic resonance images. To provide the system efficiency, feature

  16. Study of a 4{pi}{beta}-{gamma} coincidence system for absolute radionuclide activity measurement using plastic scintillators; Estudo de um sistema de coincidencias 4{pi}{beta}-{gamma} para a medida absoluta de atividade de radionuclideos empregando cintiladores plasticos

    Energy Technology Data Exchange (ETDEWEB)

    Piuvezam Filho, Helio

    2007-07-01

    The present work was intended to study a coincidence system 4{pi}(PS){beta}-{gamma} for absolute activity measurement using plastic scintillators in 4{pi} geometry. Along with experiments on the coincidence system, simulations were also performed applying the Monte Carlo Method, by means of codes PENELOPE and ESQUEMA. These simulations were performed in order to calculate the extrapolation curve of the coincidence system 4{pi}(PS){beta}-{gamma} and compare it to experimental data. A new geometry was proposed to the coincidence system adding up a second photomultiplier tube to the previous system for improving light collection from the plastic scintillator, as this system presented limitations in the minimum detected energy due to the presence of electronic noise and low gain. The results show that an improvement in the signal-to-noise ratio was obtained, as well as in the minimum detected energy. Moreover, there was an increase in the detection efficiency. With these modifications, it is now possible to calibrate radionuclides which emit low energy electrons or X-rays, increasing the number of radionuclides that can be standardized with this type of system.(author)

  17. Subwavelength image manipulation through oblique and herringbone layered acoustic systems

    International Nuclear Information System (INIS)

    Li, Chunhui; Jia, Han; Ke, Manzhu; Li, Yixiang; Liu, Zhengyou

    2014-01-01

    In this paper, an oblique and a herringbone layered acoustic structure are experimentally and theoretically demonstrated to manipulate acoustic subwavelength images. An imaging resolution of less than one tenth of a wavelength is achieved with both optimized systems, and lateral image shift has been realized by an oblique layered system. The thicknesses of both the oblique and the herringbone layered acoustic systems are largely reduced through utilizing the oblique or herringbone wave propagation path instead of the vertical wave propagation path in the rectangular layered planar acoustic system. With smaller size and subwavelength image manipulation, the acoustic systems are more favourable for practical application. (paper)

  18. Clinical study on myocardial imaging with. beta. -methyl-p-( sup 123 I)-iodophenyl-pentadecanoic acid in patients with mitochondrial myopathy

    Energy Technology Data Exchange (ETDEWEB)

    Kihara, Koichi; Nakajo, Masayuki; Shono, Hirohisa (Kagoshima Univ. (Japan). Faculty of Medicine) (and others)

    1992-04-01

    Myocardial imaging with {beta}-methyl-p-({sup 123}I)-iodophenyl-pentadecanoic acid ({sup 123}I-BMIPP), a new radiopharmaceutical designed to evaluate myocardial fatty acid metabolism, was performed in 7 patients with mitochondrial myopathy to detect their myocardial damages in comparison with {sup 201}Tl myocardial imaging. These patients were divided into 4 chronic progressive external ophthalmoplegia (CPEO) cases, 2 mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) cases and 1 myoclonus epilepsy with ragged-red fibers (MERRF). In visual assessment, we observed more myocardial segments with decreased uptake of {sup 123}I-BMIPP compared to {sup 201}Tl in MELAS cases than in CPEO cases. The mean myocardial uptake of {sup 123}I-BMIPP was higher than that of {sup 201}Tl in CPEO cases. On the other hand, in MELAS and MERRF cases, the mean myocardial uptake of {sup 123}I-BMIPP was lower than that of {sup 201}Tl. Abnormal findings suggesting myocardial damages were observed in echocardiogram and/or in electrocardiogram in MELAS and MERRF cases, while no such abnormal findings were observed in CPEO cases. Along with the previously reported experimental result that the impairment of rat myocardial mitochondria decreased myocardial uptake of {sup 123}I-BMIPP, these results suggest that {sup 123}I-BMIPP may be useful to detect myocardial damages in patients with mitochondrial myopathy. (author)

  19. Dynamic MR imaging in the musculoskeletal system

    International Nuclear Information System (INIS)

    Hedlund, L.; Vogler, J.; Utz, J.A.; Herfkens, R.J.; Martinez, S.; Urbaniak, J.; Evans, A.

    1986-01-01

    Many joint disorders are related to movement, and lack of dynamic imaging has thus far been a limitation of MR imaging. A recently developed dynamic MR imaging technique utilizing a gradient refocused echo (TE = 12 msec, TR = 21 msec) coupled to a physiologic trigger allows dynamic images of the moving joint to be obtained. Controlled joint articulation is produced using an air-driven nonmagnetic device. Imaging of the wrist by this technique demonstrated the dynamic motion of the carpal rows. The method displays cartilage with more sensitivity than does conventional MR imaging; thus, ligamentous and triangular cartilage alignment could be evaluated during motion. In the wrist, potential applications include imaging of carpal instability syndromes, ligamentous interruption, and tears of the triangular cartilage

  20. Systems of imaging digital systems in case of glaucoma

    International Nuclear Information System (INIS)

    Fernandez Argones, Liamet; Piloto Diaz, Ibrain; Coba Penna, Maria Josefa; Perez Tamayo, Bertila; Dominguez Randulfe, Marerneda; Trujillo Fonseca, Katia

    2009-01-01

    Now a day we can't consider the strict follow up in Glaucoma without the use of the digital analysis of image system of the optic nerve head and the retinal nerve fiber layer. This is a review about some contributions of Scanning Laser Polarimetry (GDx VCC, Carl Zeiss Meditec, Dublin, CA), Confocal Scanning Laser (Heidelberg Retina Tomograph HRT, Heidelberg Engineering Inc.) and Optical Coherence Tomography (Stratus OCT, Carl Zeiss Meditec, Alemania) in the diagnosis and follow up of Glaucoma. It's considered that objective measurement giving by them must be incorporate in the rigorous analysis of each glaucomatous patient

  1. Investigation of physical imaging properties in various digital radiography systems

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Hoi Woun [Dept. of Radiological Science, Baekseok Culture University, Cheonan (Korea, Republic of); Min, Jung Hwan [Dept. of Radiological technology, Shingu University, Seongnam (Korea, Republic of); Yoon, Yong Su [Dept. of Health Sciences, Graduate School of Medical Sciences, Kyushu University, Kyushu (Japan); Kim, Jung Min [Dept. of Health and Environmental Science, College of Health Science, Korea University, Seoul (Korea, Republic of)

    2017-09-15

    We aimed to evaluate the physical imaging properties in various digital radiography systems with charged coupled device (CCD), computed radiography (CR), and indirect flat panel detector (FPD). The imaging properties measured in this study were modulation transfer function (MTF) wiener spectrum (WS), and detective quantum efficiency (DQE) to compare the performance of each digital radiography system. The system response of CCD were in a linear relationship with exposure and that of CR and FPD were proportional to the logarithm of exposure. The MTF of both CR and FPD indicated a similar tendency but in case of CCD, it showed lower MTF than that of CR and FPD. FPD showed the lowest WS and also indicated the highest DQE among three systems. According to the results, digital radiography system with different type of image receptor had its own image characteristics. Therefore, it is important to know the physical imaging characteristics of the digital radiography system accurately to obtain proper image quality.

  2. Optimization of a Biometric System Based on Acoustic Images

    Directory of Open Access Journals (Sweden)

    Alberto Izquierdo Fuente

    2014-01-01

    Full Text Available On the basis of an acoustic biometric system that captures 16 acoustic images of a person for 4 frequencies and 4 positions, a study was carried out to improve the performance of the system. On a first stage, an analysis to determine which images provide more information to the system was carried out showing that a set of 12 images allows the system to obtain results that are equivalent to using all of the 16 images. Finally, optimization techniques were used to obtain the set of weights associated with each acoustic image that maximizes the performance of the biometric system. These results improve significantly the performance of the preliminary system, while reducing the time of acquisition and computational burden, since the number of acoustic images was reduced.

  3. Optimization of a Biometric System Based on Acoustic Images

    Science.gov (United States)

    Izquierdo Fuente, Alberto; Del Val Puente, Lara; Villacorta Calvo, Juan J.; Raboso Mateos, Mariano

    2014-01-01

    On the basis of an acoustic biometric system that captures 16 acoustic images of a person for 4 frequencies and 4 positions, a study was carried out to improve the performance of the system. On a first stage, an analysis to determine which images provide more information to the system was carried out showing that a set of 12 images allows the system to obtain results that are equivalent to using all of the 16 images. Finally, optimization techniques were used to obtain the set of weights associated with each acoustic image that maximizes the performance of the biometric system. These results improve significantly the performance of the preliminary system, while reducing the time of acquisition and computational burden, since the number of acoustic images was reduced. PMID:24616643

  4. Development of a PET/Cerenkov-light hybrid imaging system

    International Nuclear Information System (INIS)

    Yamamoto, Seiichi; Hamamura, Fuka; Kato, Katsuhiko; Ogata, Yoshimune; Watabe, Tadashi; Ikeda, Hayato; Kanai, Yasukazu; Hatazawa, Jun; Watabe, Hiroshi

    2014-01-01

    Purpose: Cerenkov-light imaging is a new molecular imaging technology that detects visible photons from high-speed electrons using a high sensitivity optical camera. However, the merit of Cerenkov-light imaging remains unclear. If a PET/Cerenkov-light hybrid imaging system were developed, the merit of Cerenkov-light imaging would be clarified by directly comparing these two imaging modalities. Methods: The authors developed and tested a PET/Cerenkov-light hybrid imaging system that consists of a dual-head PET system, a reflection mirror located above the subject, and a high sensitivity charge coupled device (CCD) camera. The authors installed these systems inside a black box for imaging the Cerenkov-light. The dual-head PET system employed a 1.2 × 1.2 × 10 mm 3 GSO arranged in a 33 × 33 matrix that was optically coupled to a position sensitive photomultiplier tube to form a GSO block detector. The authors arranged two GSO block detectors 10 cm apart and positioned the subject between them. The Cerenkov-light above the subject is reflected by the mirror and changes its direction to the side of the PET system and is imaged by the high sensitivity CCD camera. Results: The dual-head PET system had a spatial resolution of ∼1.2 mm FWHM and sensitivity of ∼0.31% at the center of the FOV. The Cerenkov-light imaging system's spatial resolution was ∼275μm for a 22 Na point source. Using the combined PET/Cerenkov-light hybrid imaging system, the authors successfully obtained fused images from simultaneously acquired images. The image distributions are sometimes different due to the light transmission and absorption in the body of the subject in the Cerenkov-light images. In simultaneous imaging of rat, the authors found that 18 F-FDG accumulation was observed mainly in the Harderian gland on the PET image, while the distribution of Cerenkov-light was observed in the eyes. Conclusions: The authors conclude that their developed PET/Cerenkov-light hybrid imaging

  5. A new remote-imaging diagnosis system at Komazawa University

    International Nuclear Information System (INIS)

    Shimada, Morio; Kohda, Eiichi; Yoshikawa, Kohki

    2007-01-01

    We developed a remote-imaging diagnosis system that links the highly experienced radiologists at Komazawa University with Fuji Electric Hospital, where no such radiologists are present. MRI or CT images from Fuji Electric hospital are transmitted to Komazawa University via private line (INS64). The radiologists at Komazawa University then read the MRI or CT images, and relay the results to Fuji Electric Hospital. We describe the advantages and disadvantages of this system. MRI or CT imaging data from 80 cases were used. The data were stored in the imaging system server at Fuji Electric Hospital and were evaluated by experienced radiologists at Komazawa University. The images were sent one by one to the diagnostic support system server at Komazawa University through the private INS64 line. We examined transmission time per case and the security of transmission. Transmission of MRI or CT images from the 80 cases required a mean duration of 63 minutes 30 seconds per image. The quality of all images was highly satisfactory. In addition, there was no evidence of weaknesses in security. A physician at Fuji Electric Hospital was able to readily explain to the patient the results of the images by referring to the findings written by a radiologist at Komazawa University. We were able to transmit MRI or CT images by using this system safely and readily. The primary disadvantage of this system was the slow transmission speed. This will be improved by upgrading to an optical fibers. (author)

  6. 21 CFR 892.1550 - Ultrasonic pulsed doppler imaging system.

    Science.gov (United States)

    2010-04-01

    ... system. (a) Identification. An ultrasonic pulsed doppler imaging system is a device that combines the... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Ultrasonic pulsed doppler imaging system. 892.1550... include signal analysis and display equipment, patient and equipment supports, component parts, and...

  7. 21 CFR 892.1560 - Ultrasonic pulsed echo imaging system.

    Science.gov (United States)

    2010-04-01

    ... system. (a) Identification. An ultrasonic pulsed echo imaging system is a device intended to project a... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Ultrasonic pulsed echo imaging system. 892.1560... receiver. This generic type of device may include signal analysis and display equipment, patient and...

  8. A simple polarized-based diffused reflectance colour imaging system

    African Journals Online (AJOL)

    A simple polarized-based diffuse reflectance imaging system has been developed. The system is designed for both in vivo and in vitro imaging of agricultural specimen in the visible region. The system uses a commercial web camera and a halogen lamp that makes it relatively simple and less expensive for diagnostic ...

  9. Digital image processing software system using an array processor

    International Nuclear Information System (INIS)

    Sherwood, R.J.; Portnoff, M.R.; Journeay, C.H.; Twogood, R.E.

    1981-01-01

    A versatile array processor-based system for general-purpose image processing was developed. At the heart of this system is an extensive, flexible software package that incorporates the array processor for effective interactive image processing. The software system is described in detail, and its application to a diverse set of applications at LLNL is briefly discussed. 4 figures, 1 table

  10. System and method for three-dimensional image reconstruction using an absolute orientation sensor

    KAUST Repository

    Giancola, Silvio; Ghanem, Bernard; Schneider, Jens; Wonka, Peter

    2018-01-01

    A three-dimensional image reconstruction system includes an image capture device, an inertial measurement unit (IMU), and an image processor. The image capture device captures image data. The inertial measurement unit (IMU) is affixed to the image

  11. The operation technology of realtime image processing system (Datacube)

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Jai Wan; Lee, Yong Bum; Lee, Nam Ho; Choi, Young Soo; Park, Soon Yong; Park, Jin Seok

    1997-02-01

    In this project, a Sparc VME-based MaxSparc system, running the solaris operating environment, is selected as the dedicated image processing hardware for robot vision applications. In this report, the operation of Datacube maxSparc system, which is high performance realtime image processing hardware, is systematized. And image flow example programs for running MaxSparc system are studied and analyzed. The state-of-the-arts of Datacube system utilizations are studied and analyzed. For the next phase, advanced realtime image processing platform for robot vision application is going to be developed. (author). 19 refs., 71 figs., 11 tabs.

  12. Design and simulation of a totally digital image system for medical image applications

    International Nuclear Information System (INIS)

    Archwamety, C.

    1987-01-01

    The Totally Digital Imaging System (TDIS) is based on system requirements information from the Radiology Department, University of Arizona Health Science Center. This dissertation presents the design of this complex system, the TDIS specification, the system performance requirements, and the evaluation of the system using the computer-simulation programs. Discrete-event simulation models were developed for the TDIS subsystems, including an image network, imaging equipment, storage migration algorithm, data base archive system, and a control and management network. The simulation system uses empirical data generation and retrieval rates measured at the University Medical Center hospital. The entire TDIS system was simulated in Simscript II.5 using a VAX 8600 computer system. Simulation results show the fiber-optical-image network to be suitable; however, the optical-disk-storage system represents a performance bottleneck

  13. (New imaging systems in nuclear medicine)

    Energy Technology Data Exchange (ETDEWEB)

    1990-01-01

    Further progress has been made on improving the uniformity and stability of PCR-I, the single ring analog coded tomograph. This camera has been employed in a wide range of animal studies described below. Data from PCR-I have been used in various image processing procedures. These include motion pictures of dog heart, comparison of PET and MRI image in dog heart and rat brain and quantitation of tumor metabolism in the nude mouse using blood data from heart images. A SUN workstation with TAAC board has been used to produce gated three-dimensional images of the dog heart. The ANALYZE program from the Mayo Clinic has also been mounted on a SUN workstation for comparison of images and image processing. 15 refs., 6 figs.

  14. [New imaging systems in nuclear medicine

    International Nuclear Information System (INIS)

    1990-01-01

    Further progress has been made on improving the uniformity and stability of PCR-I, the single ring analog coded tomograph. This camera has been employed in a wide range of animal studies described below. Data from PCR-I have been used in various image processing procedures. These include motion pictures of dog heart, comparison of PET and MRI image in dog heart and rat brain and quantitation of tumor metabolism in the nude mouse using blood data from heart images. A SUN workstation with TAAC board has been used to produce gated three-dimensional images of the dog heart. The ANALYZE program from the Mayo Clinic has also been mounted on a SUN workstation for comparison of images and image processing. 15 refs., 6 figs

  15. Designing a stable feedback control system for blind image deconvolution.

    Science.gov (United States)

    Cheng, Shichao; Liu, Risheng; Fan, Xin; Luo, Zhongxuan

    2018-05-01

    Blind image deconvolution is one of the main low-level vision problems with wide applications. Many previous works manually design regularization to simultaneously estimate the latent sharp image and the blur kernel under maximum a posterior framework. However, it has been demonstrated that such joint estimation strategies may lead to the undesired trivial solution. In this paper, we present a novel perspective, using a stable feedback control system, to simulate the latent sharp image propagation. The controller of our system consists of regularization and guidance, which decide the sparsity and sharp features of latent image, respectively. Furthermore, the formational model of blind image is introduced into the feedback process to avoid the image restoration deviating from the stable point. The stability analysis of the system indicates the latent image propagation in blind deconvolution task can be efficiently estimated and controlled by cues and priors. Thus the kernel estimation used for image restoration becomes more precision. Experimental results show that our system is effective on image propagation, and can perform favorably against the state-of-the-art blind image deconvolution methods on different benchmark image sets and special blurred images. Copyright © 2018 Elsevier Ltd. All rights reserved.

  16. Beta-particle dosimetry of the trabecular skeleton using Monte Carlo transport within 3D digital images

    International Nuclear Information System (INIS)

    Jokisch, D.W.; Bouchet, L.G.; Patton, P.W.; Rajon, D.A.; Bolch, W.E.

    2001-01-01

    Presently, skeletal dosimetry models utilized in clinical medicine simulate electron path lengths through skeletal regions based upon distributions of linear chords measured across bone trabeculae and marrow cavities. In this work, a human thoracic vertebra has been imaged via nuclear magnetic resonance (NMR) spectroscopy yielding a three-dimensional voxelized representation of this skeletal site. The image was then coupled to the radiation transport code EGS4 allowing for 3D tracing of electron paths within its true 3D structure. The macroscopic boundaries of the trabecular regions, as well as the cortex of cortical bone surrounding the bone site, were explicitly considered in the voxelized transport model. For the case of a thoracic vertebra, energy escape to the cortical bone became significant at source energies exceeding ∼2 MeV. Chord-length distributions were acquired from the same NMR image, and subsequently used as input for a chord-based dosimetry model. Differences were observed in the absorbed fractions given by the chord-based model and the voxel transport model, suggesting that some of the input chord distributions for the chord-based models may not be accurate. Finally, this work shows that skeletal mass estimates can be made from the same NMR image in which particle transport is performed. This feature allows one to determine a skeletal S-value using absorbed fraction and mass data taken from the same anatomical tissue sample. The techniques developed in this work may be applied to a variety of skeletal sites, thus allowing for the development of skeletal dosimetry models at all skeletal sites for both males and females and as a function of subject age

  17. Geometrical optics in correlated imaging systems

    International Nuclear Information System (INIS)

    Cao Dezhong; Xiong Jun; Wang Kaige

    2005-01-01

    We discuss the geometrical optics of correlated imaging for two kinds of spatial correlations corresponding, respectively, to a classical thermal light source and a quantum two-photon entangled source. Due to the different features in the second-order spatial correlation, the two sources obey different imaging equations. The quantum entangled source behaves as a mirror, whereas the classical thermal source looks like a phase-conjugate mirror in the correlated imaging

  18. Infrared Images of an Infant Solar System

    Science.gov (United States)

    2002-05-01

    ESO Telescopes Detect a Strange-Looking Object Summary Using the ESO 3.5-m New Technology Telescope and the Very Large Telescope (VLT) , a team of astronomers [1] have discovered a dusty and opaque disk surrounding a young solar-type star in the outskirts of a dark cloud in the Milky Way. It was found by chance during an unrelated research programme and provides a striking portrait of what our Solar System must have looked like when it was in its early infancy. Because of its striking appearance, the astronomers have nicknamed it the "Flying Saucer" . The new object appears to be a perfect example of a very young star with a disk in which planets are forming or will soon form, and located far away from the usual perils of an active star-forming environment . Most other young stars, especially those that are born in dense regions, run a serious risk of having their natal dusty disks destroyed by the blazing radiation of their more massive and hotter siblings in these clusters. The star at the centre of the "Flying Saucer", seems destined to live a long and quiet life at the centre of a planetary system , very much like our own Sun. This contributes to making it a most interesting object for further studies with the VLT and other telescopes. The mass of the observed disk of gas and dust is at least twice that of the planet Jupiter and its radius measures about 45 billion km, or 5 times the size of the orbit of Neptune. PR Photo 12a/02 : The "Flying Saucer" object photographed with NTT/SOFI. PR Photo 12b/02 : VLT/ISAAC image of this object. PR Photo 12c/02 : Enlargement of VLT/ISAAC image . Circumstellar Disks and Planets Planets form in dust disks around young stars. This is a complex process of which not all stages are yet fully understood but it begins when small dust particles collide and stick to each other. For this reason, observations of such dust disks, in particular those that appear as extended structures (are "resolved"), are very important for our

  19. Modeling the effects of repeated systemic administrations of small activity amounts In radionuclide therapy with beta emitters

    International Nuclear Information System (INIS)

    Calderon, Carlos; Gonzalez, Joaquin; Cepero, Janet; Colom, Camila; Rodriguez, Juan C.

    2008-01-01

    Full text: Good results for radionuclide therapy treatments where repeated short time spaced systemic injection of small activity amounts are given have been reported. Bone marrow and kidneys are usually considered as dose-limiting organs in radionuclide therapy. The treatments in radionuclide therapy with repeated administration could be optimized if irradiation effects in those one might be estimated. Xeno-grafted mice is the often biological model used during the evaluation of candidates for radionuclide therapy. A mathematical model of tumor cell kinetics was combined with another one reported for marrow cell kinetics which allows the calculation of marrow cell survival and proliferation in response to different irradiation schemes. Radionuclide therapy treatment with repeated administrations with radiopharmaceuticals labeled with beta emitters were simulated. The effects on fast-growing and slow-growing tumors were evaluated, as well as radiosensitive and radioresistant tumors. For more realistic estimation of absorbed dose in mice organs the cross-irradiation due to high energy beta particles was included into the MIRD's formula. Tumor and kidneys responses to the irradiation were estimated on the linear-quadratic model framework which was adapted for a multi-exponential dose rate function describing radionuclide therapy treatments with repeated administrations. Published values for murine tumors kinetics, marrows cellular turnover rates and radiosensitivities were used during the calculations. Iso-effective schemes were also determined varying the interval between fractions and the number of administration. For a given tolerated level of thrombocytopenia and absorbed dose in kidneys an optimal regime of radionuclide therapy with repeated administration could be found. The mathematical model presented here allows the prediction of the nadir and duration of thrombocytopenia, the effects on kidneys and the tumor cell response to various treatment schemes

  20. Tuning the stereo-hindrance of a curcumin scaffold for the selective imaging of the soluble forms of amyloid beta species.

    Science.gov (United States)

    Li, Yuyan; Yang, Jian; Liu, Hongwu; Yang, Jing; Du, Lei; Feng, Haiwei; Tian, Yanli; Cao, Jianqin; Ran, Chongzhao

    2017-11-01

    Amyloid peptides and proteins are associated with the pathologies of numerous diseases. In the progression of a disease, amyloids exist in soluble and insoluble forms, which are the dominant species at different stages of the disease and they have different degrees of toxicity. However, differentiating between the soluble and insoluble forms is very challenging with small molecule probes due to multiple obstacles that need to be overcome. Inspired by the recognition principle of antibodies for sAβ, we hypothesized that the accessibility/tightness of soluble and insoluble amyloids could be utilized to design imaging probes to recognize different amyloid forms and the stereo-hindrance tuning strategy could be used to design imaging probes for selectively detecting the soluble amyloid beta (sAβ) species in Alzheimer's disease (AD). Herein, we demonstrated that tuning the stereo-hindrance of the phenoxy-alkyl chains at the 4-position of a curcumin scaffold could lead to certain selectivity for sAβ over insoluble Aβs (insAβ). Among the designed compounds, CRANAD-102 showed a 68-fold higher affinity for sAβ than for insAβ (7.5 ± 10 nM vs. 505.9 ± 275.9 nM). Moreover, our imaging data indicated that CRANAD-102 was indeed capable of detecting sAβ in vivo using 4 month old APP/PS1 mice, in which sAβ is the predominant species in the brain. In addition, we also demonstrated that CRANAD-102 could be used to monitor the increase in sAβ loading from the ages of 4 months old to 12 months old. We believe that CRANAD-102 can be a useful probe for selectively detecting sAβ species in AD and that our probe designing strategy can be applied to other amyloids and will have tremendous impact on AD drug development and other amyloid research.

  1. PARAGON-IPS: A Portable Imaging Software System For Multiple Generations Of Image Processing Hardware

    Science.gov (United States)

    Montelione, John

    1989-07-01

    Paragon-IPS is a comprehensive software system which is available on virtually all generations of image processing hardware. It is designed for an image processing department or a scientist and engineer who is doing image processing full-time. It is being used by leading R&D labs in government agencies and Fortune 500 companies. Applications include reconnaissance, non-destructive testing, remote sensing, medical imaging, etc.

  2. Ultrasound Vector Flow Imaging: Part II: Parallel Systems

    DEFF Research Database (Denmark)

    Jensen, Jørgen Arendt; Nikolov, Svetoslav Ivanov; Yu, Alfred C. H.

    2016-01-01

    The paper gives a review of the current state-of-theart in ultrasound parallel acquisition systems for flow imaging using spherical and plane waves emissions. The imaging methods are explained along with the advantages of using these very fast and sensitive velocity estimators. These experimental...... ultrasound imaging for studying brain function in animals. The paper explains the underlying acquisition and estimation methods for fast 2-D and 3-D velocity imaging and gives a number of examples. Future challenges and the potentials of parallel acquisition systems for flow imaging are also discussed....

  3. Lactose hydrolysis in aqueous two-phase system by whole-cell {beta}-galactosidase of Kluyveromyces marxianus. Semicontinuous and continuous processes

    Energy Technology Data Exchange (ETDEWEB)

    Tomaska, M [Slovak Technical Univ., Bratislava (Slovakia). Dept. of Biochemical Technology; Stredansky, M [Slovak Technical Univ., Bratislava (Slovakia). Dept. of Biochemical Technology; Tomaskova, A [Slovak Technical Univ., Bratislava (Slovakia). Dept. of Biochemical Technology; Sturdik, E [Slovak Technical Univ., Bratislava (Slovakia). Dept. of Biochemical Technology

    1995-01-01

    Semicontinuous and continuous hydrolysis of lactose in aqueous two-phase systems (polyethylene glycol 20000/ dextran 40) with whole-cell {beta}-galactosidase of K. marxianus were studied. Both phase polymers had no effect on {beta}-galactosidase activity confined in cells. Good operational stability of the biocatalyst during 55 cycles of semicontinuous process was observed without appreciable decrease in product concentration. Continuous hydrolysis of lactose was performed in the stirred bioreactor, connected with the phase separator. The satisfactory degree of hydrolysis (between 82-88%) and volumetric productivity (21.6 g/l/h) were reached during 72 hours of continuous hydrolysis of 5% (w/w) lactose. (orig.)

  4. A Wide Spectral Range Reflectance and Luminescence Imaging System

    Directory of Open Access Journals (Sweden)

    Tapani Hirvonen

    2013-10-01

    Full Text Available In this study, we introduce a wide spectral range (200–2500 nm imaging system with a 250 μm minimum spatial resolution, which can be freely modified for a wide range of resolutions and measurement geometries. The system has been tested for reflectance and luminescence measurements, but can also be customized for transmittance measurements. This study includes the performance results of the developed system, as well as examples of spectral images. Discussion of the system relates it to existing systems and methods. The wide range spectral imaging system that has been developed is however highly customizable and has great potential in many practical applications.

  5. The neutron imaging system fielded at the National Ignition Facility

    Directory of Open Access Journals (Sweden)

    Fittinghoff D.N.

    2013-11-01

    Full Text Available We have fielded a neutron imaging system at the National Ignition Facility to collect images of fusion neutrons produced in the implosion of inertial confinement fusion experiments and scattered neutrons from (n, n′ reactions of the source neutrons in the surrounding dense material. A description of the neutron imaging system is presented, including the pinhole array aperture, the line-of-sight collimation, the scintillator-based detection system and the alignment systems and methods. Discussion of the alignment and resolution of the system is presented. We also discuss future improvements to the system hardware.

  6. [Research on Spectral Polarization Imaging System Based on Static Modulation].

    Science.gov (United States)

    Zhao, Hai-bo; Li, Huan; Lin, Xu-ling; Wang, Zheng

    2015-04-01

    The main disadvantages of traditional spectral polarization imaging system are: complex structure, with moving parts, low throughput. A novel method of spectral polarization imaging system is discussed, which is based on static polarization intensity modulation combined with Savart polariscope interference imaging. The imaging system can obtain real-time information of spectral and four Stokes polarization messages. Compared with the conventional methods, the advantages of the imaging system are compactness, low mass and no moving parts, no electrical control, no slit and big throughput. The system structure and the basic theory are introduced. The experimental system is established in the laboratory. The experimental system consists of reimaging optics, polarization intensity module, interference imaging module, and CCD data collecting and processing module. The spectral range is visible and near-infrared (480-950 nm). The white board and the plane toy are imaged by using the experimental system. The ability of obtaining spectral polarization imaging information is verified. The calibration system of static polarization modulation is set up. The statistical error of polarization degree detection is less than 5%. The validity and feasibility of the basic principle is proved by the experimental result. The spectral polarization data captured by the system can be applied to object identification, object classification and remote sensing detection.

  7. The use of the general image quality equation in the design and evaluation of imaging systems

    Science.gov (United States)

    Cota, Steve A.; Florio, Christopher J.; Duvall, David J.; Leon, Michael A.

    2009-08-01

    The design of any modern imaging system is the end result of many trade studies, each seeking to optimize image quality within real world constraints such as cost, schedule and overall risk. The National Imagery Interpretability Rating Scale (NIIRS) is a useful measure of image quality, because, by characterizing the overall interpretability of an image, it combines into one metric those contributors to image quality to which a human interpreter is most sensitive. The main drawback to using a NIIRS rating as a measure of image quality in engineering trade studies is the fact that it is tied to the human observer and cannot be predicted from physical principles and engineering parameters alone. The General Image Quality Equation (GIQE) of Leachtenauer et al. 1997 [Appl. Opt. 36, 8322-8328 (1997)] is a regression of actual image analyst NIIRS ratings vs. readily calculable engineering metrics, and provides a mechanism for using the expected NIIRS rating of an imaging system in the design and evaluation process. In this paper, we will discuss how we use the GIQE in conjunction with The Aerospace Corporation's Parameterized Image Chain Analysis & Simulation SOftware (PICASSO) to evaluate imager designs, taking a hypothetical high resolution commercial imaging system as an example.

  8. Use of Beta-Blockers and Aspirin in Acute Coronary Syndromes by Patient Renal Function in the Military Healthcare Systems, National Capital Area

    National Research Council Canada - National Science Library

    Abbott, Kevin C

    2005-01-01

    ...) hospital system from 2001 through 2004. Use of beta-blockers (BB) and aspirin (ASA) at the time of discharge after AMI was assessed according to serum creatinine level, stratified by admission to the coronary care unit (CCU) vs. other wards...

  9. NMR imaging of the musculoskeletal system

    International Nuclear Information System (INIS)

    Naegele, M.; Lienemann, A.; Hahn, D.

    1988-01-01

    NMR imaging now allows in vivo imaging of soft tissue hitherto undetectable by non-invasive means. This opens up excellent perspectives with regard to the diagnosis and therapy of various diseases in the field of traumatology and oncology, of which examples are discussed in this paper. (orig.) [de

  10. A NIM (Nuclear Instrumentation Module) system conjugated with optional input for pHEMT amplifier for beta and gamma spectroscopy

    International Nuclear Information System (INIS)

    Konrad, Barbara; Lüdke, Everton

    2014-01-01

    This work presents a high speed NIM module (Nuclear Instrumentation Module) to detect radiation, gamma and muons, as part of a system for natural radiation monitoring and of extraterrestrial origin. The subsystem developed consists of a preamplifier and an integrated SCA (Single Channel Analyzer), including power supplies of ± 12 and ± 24V with derivations of +3.6 and ± 5V. The single channel analyzer board, consisting of discrete logic components, operating in window modes, normal and integral. The pulse shaping block is made up of two voltage comparators working at 120 MHz with a response time > 60 ns and a logic anticoincidence system. The preamplifier promotes a noise reduction and introduces the impedance matching between the output of anode / diode photomultiplier tubes (PMTs) and subsequent equipment, providing an input impedance of 1MΩ and output impedance of 40 to 140Ω. The shaper amplifier is non-inverting and has variable input capacitance of 1000 pF. The upper and lower thresholds of the SCA are adjustable from 0 to ± 10V, and the equipment is compatible with various types of detectors, like PMTs coupled to sodium iodide crystals. For use with liquid scintillators and photodiodes with crystals (CsI: Tl) is proposed to include a preamplifier circuit pHEMT (pseudomorphic High Electron Mobility Transistor) integrated. Yet, the system presents the possibility of applications for various purposes of gamma spectroscopy and automatic detection of events producing of beta particles

  11. Kingfisher: a system for remote sensing image database management

    Science.gov (United States)

    Bruzzo, Michele; Giordano, Ferdinando; Dellepiane, Silvana G.

    2003-04-01

    At present retrieval methods in remote sensing image database are mainly based on spatial-temporal information. The increasing amount of images to be collected by the ground station of earth observing systems emphasizes the need for database management with intelligent data retrieval capabilities. The purpose of the proposed method is to realize a new content based retrieval system for remote sensing images database with an innovative search tool based on image similarity. This methodology is quite innovative for this application, at present many systems exist for photographic images, as for example QBIC and IKONA, but they are not able to extract and describe properly remote image content. The target database is set by an archive of images originated from an X-SAR sensor (spaceborne mission, 1994). The best content descriptors, mainly texture parameters, guarantees high retrieval performances and can be extracted without losses independently of image resolution. The latter property allows DBMS (Database Management System) to process low amount of information, as in the case of quick-look images, improving time performance and memory access without reducing retrieval accuracy. The matching technique has been designed to enable image management (database population and retrieval) independently of dimensions (width and height). Local and global content descriptors are compared, during retrieval phase, with the query image and results seem to be very encouraging.

  12. A review of imaging techniques for systems biology

    Directory of Open Access Journals (Sweden)

    Po Ming J

    2008-08-01

    Full Text Available Abstract This paper presents a review of imaging techniques and of their utility in system biology. During the last decade systems biology has matured into a distinct field and imaging has been increasingly used to enable the interplay of experimental and theoretical biology. In this review, we describe and compare the roles of microscopy, ultrasound, CT (Computed Tomography, MRI (Magnetic Resonance Imaging, PET (Positron Emission Tomography, and molecular probes such as quantum dots and nanoshells in systems biology. As a unified application area among these different imaging techniques, examples in cancer targeting are highlighted.

  13. Effects of scanning resolution and digital image magnification on photostimulable phosphor imaging system

    International Nuclear Information System (INIS)

    Sakurai, Takashi; Inagaki, Masafumi; Asai, Hideomi; Koyama, Atsushi; Kashima, Isamu

    2000-01-01

    The purpose of this study is to examine the effects of changes in scanning resolution and digital magnification on the image quality and diagnostic ability of the photostimulable phosphor imaging system. Using a photostimulable phosphor imaging system, images of a human adult dried mandible phantom embedded in a 25 mm-thick epoxy resin block were made. The latent images on the photostimulable phosphor imaging plate were scanned using four different pixel sizes as follows: 25 μm x 25 μm, 50 μm x 50 μm, 100 μm x 100 μm and 200 μm x 200 μm. A primary image was produced for each pixel size. These images were also digitally magnified at powers of 2, 4 and 8 times. The gradient range, brightness and contrast of each image were adjusted to optimum levels on a cathode ray tube display, and hard copies were produced with a writing pixel size of 60 μm x 60 μm. The granularity, sharpness and anatomical diagnostic ability of the images were assessed subjectively by eight dentists. Increasing the scanning resolution tended to generally improve image quality and diagnostic ability. Visual image quality was maintained up to a pixel size of 50 μm, and diagnostic ability was maintained up to a pixel size of 100 μm. Digital image magnification degraded image quality, and more than 2-times magnification degraded diagnostic ability. Under the present experimental conditions, increasing the scanning resolution did not always lead to an improvement in image quality or diagnostic ability, and digital image magnification degraded image quality and diagnostic ability. (author)

  14. {alpha}{sub v}{beta}{sub 3} imaging can accurately distinguish between mature teratoma and necrosis in {sup 18}F-FDG-negative residual masses after treatment of non-seminomatous testicular cancer: a preclinical study

    Energy Technology Data Exchange (ETDEWEB)

    Aide, Nicolas [Francois Baclesse Cancer Centre and Caen University, Bioticla Team, EA1772, IFR 146 ICORE, GRECAN, Caen (France); Caen University Hospital and Francois Baclesse Cancer Centre, PET Unit, Caen (France); Centre Francois Baclesse, Service de Medecine Nucleaire, Caen (France); Briand, Melanie; Dutoit, Soizic; Deslandes, Edwiges; Poulain, Laurent [Francois Baclesse Cancer Centre and Caen University, Bioticla Team, EA1772, IFR 146 ICORE, GRECAN, Caen (France); Bohn, Pierre; Rouvet, Jean; Modzelewski, Romain; Vera, Pierre [Henri Becquerel Cancer Center and Rouen University Hospital and QuantIF- LITIS (EA4108), Department of Nuclear Medicine, Rouen (France); Lasnon, Charline [Caen University Hospital and Francois Baclesse Cancer Centre, PET Unit, Caen (France); Chasle, Jacques [Francois Baclesse Cancer Centre and Caen University, Pathology Department, Caen (France); Vela, Antony [Francois Baclesse Cancer Centre and Caen University, Radiophysics Unit, Caen (France); Carreiras, Franck [Universite de Cergy Pontoise, UFR Sciences et Techniques, ERRMECe, EA 1391, Institut des materiaux, Cergy-Pontoise (France)

    2011-02-15

    We assessed whether imaging {alpha}{sub v}{beta}{sub 3} integrin could distinguish mature teratoma from necrosis in human non-seminomatous germ cell tumour (NSGCT) post-chemotherapy residual masses. Human embryonal carcinoma xenografts (six/rat) were untreated (controls) or treated to form mature teratomas with low-dose cisplatin and all-trans retinoic acid (ATRA) over a period of 8 weeks. In another group, necrosis was induced in xenografts with high-dose cisplatin plus etoposide (two cycles).{sup 18}F-Fluorodeoxyglucose ({sup 18}F-FDG) small animal positron emission tomography (SA PET) imaging was performed in three rats (one control and two treated for 4 and 8 weeks with cisplatin+ATRA). Imaging of {alpha}{sub v}{beta}{sub 3} expression was performed in six rats bearing mature teratomas and two rats with necrotic lesions on a microSPECT/CT device after injection of the tracer [{sup 99m}Tc]HYNIC-RGD [6-hydrazinonicotinic acid conjugated to cyclo(Arg-Gly-Asp-D-Phe-Lys)]. Correlative immunohistochemistry studies of human and mouse {alpha}{sub v}{beta}{sub 3} expression were performed. Cisplatin+ATRA induced differentiation of the xenografts. After 8 weeks, some glandular structures and mesenchymal cells were visible; in contrast, control tumours showed undifferentiated tissues. SA PET imaging showed that mature teratoma had very low avidity for {sup 18}F-FDG [mean standardised uptake value (SUV{sub mean}) = 0.48 {+-} 0.05] compared to untreated embryonal carcinoma (SUV{sub mean} = 0.92 {+-} 0.13) (p = 0.005). {alpha}{sub v}{beta}{sub 3} imaging accurately distinguished mature teratoma (tumour to muscle ratio = 4.29 {+-} 1.57) from necrosis (tumour to muscle ratio = 1.3 {+-} 0.26) (p = 0.0002). Immunohistochemistry studies showed that {alpha}{sub v}{beta}{sub 3} integrin expression was strong in the glandular structures of mature teratoma lesions and negative in host stroma. Imaging {alpha}{sub v}{beta}{sub 3} integrin accurately distinguished mature teratoma from

  15. A secure online image trading system for untrusted cloud environments.

    Science.gov (United States)

    Munadi, Khairul; Arnia, Fitri; Syaryadhi, Mohd; Fujiyoshi, Masaaki; Kiya, Hitoshi

    2015-01-01

    In conventional image trading systems, images are usually stored unprotected on a server, rendering them vulnerable to untrusted server providers and malicious intruders. This paper proposes a conceptual image trading framework that enables secure storage and retrieval over Internet services. The process involves three parties: an image publisher, a server provider, and an image buyer. The aim is to facilitate secure storage and retrieval of original images for commercial transactions, while preventing untrusted server providers and unauthorized users from gaining access to true contents. The framework exploits the Discrete Cosine Transform (DCT) coefficients and the moment invariants of images. Original images are visually protected in the DCT domain, and stored on a repository server. Small representation of the original images, called thumbnails, are generated and made publicly accessible for browsing. When a buyer is interested in a thumbnail, he/she sends a query to retrieve the visually protected image. The thumbnails and protected images are matched using the DC component of the DCT coefficients and the moment invariant feature. After the matching process, the server returns the corresponding protected image to the buyer. However, the image remains visually protected unless a key is granted. Our target application is the online market, where publishers sell their stock images over the Internet using public cloud servers.

  16. A novel secret image sharing scheme based on chaotic system

    Science.gov (United States)

    Li, Li; Abd El-Latif, Ahmed A.; Wang, Chuanjun; Li, Qiong; Niu, Xiamu

    2012-04-01

    In this paper, we propose a new secret image sharing scheme based on chaotic system and Shamir's method. The new scheme protects the shadow images with confidentiality and loss-tolerance simultaneously. In the new scheme, we generate the key sequence based on chaotic system and then encrypt the original image during the sharing phase. Experimental results and analysis of the proposed scheme demonstrate a better performance than other schemes and confirm a high probability to resist brute force attack.

  17. Design and construction of an interface system for the extrapolation chamber from the beta secondary standard.; Diseno y construccion del sistema de interfaz para la camara de extrapolacion del patron secundario beta.

    Energy Technology Data Exchange (ETDEWEB)

    Jimenez C, L F

    1995-10-01

    The Interface System for the Extrapolation Chamber (SICE) contains several devices handled by a personal computer (PC), it is able to get the required data to calculate the absorbed dose due to Beta radiation. The main functions of the system are: (a) Measures the ionization current or charge stored in the extrapolation chamber. (b) Adjusts the distance between the plates of the extrapolation chamber automatically. (c) Adjust the bias voltage of the extrapolation chamber automatically. (d) Acquires the data of the temperature, atmospheric pressure, relative humidity of the environment and the voltage applied between the plates of the extrapolation chamber. (e) Calculates the effective area of the plates of the extrapolation chamber and the real distance between them. (f) Stores all the obtained information in hard disk or diskette. A comparison between the desired distance and the distance in the dial of the extrapolation chamber, show us that the resolution of the system is of 20 {mu}m. The voltage can be changed between -399.9 V and +399.9 V with an error of less the 3% with a resolution of 0.1 V. These uncertainties are between the accepted limits to be used in the determination of the absolute absorbed dose due to beta radiation. (Author).

  18. Digital radiology and digitally formatted image management systems

    International Nuclear Information System (INIS)

    Cox, G.G.; Dwyer, S.J. III; Templeton, A.W.

    1987-01-01

    The number of diagnostic examinations performed with digitally formatted imaging equipment is increasing. Digital general-purpose and fluoroscopic radiology systems are being clinically evaluated. Digitizing conventional x-ray films, such as mammograms, frequently improves the diagnostic quality of the images. The digitizing process with laser has also afforded the opportunity to document required spatial resolution for digital imaging and network systems. The use of digitally formatted image instrumentation imposes new requirements on the acquisition, display and manipulation, transmission, hard copy image recording, and archiving of diagnostic data. Networking of digitally formatted image data offers many advantages for managing digital information. This paper identifies and describes digital radiographic systems. Parameters required for designing and implementing a digital image management system are outlined. Spatial and contrast resolution requirements are identified. The key parameters include the amount of image data generated each working day, the retrieval rate of the generated data, the display hardware and software needed for interactive diagnosis display stations, the requirements for analog hard copy generation, and on-line and long-term archiving requirements. These image management systems are often called PACS (Picture Archiving and Communication Systems)

  19. Magnetic resonance imaging of central nervous system haemorrhage

    International Nuclear Information System (INIS)

    Silberstein, M.; Hennessy, O.

    1993-01-01

    The variable magnetic resonance imaging appearances of central nervous system haemorrhage, both intra- and extra-axial, are described. These will vary with the type of image contrast (T1 or T2 weighting), the nature of the imaging sequence (spin-echo or gradient-echo) and the time from onset of haemorrhage. Magnetic resonance imaging is a useful technique for imaging haemorrhage in the central nervous system as it yields temporal information about haematoma development, and it is the only non-invasive means of imaging intraspinal haemorrhage. However, in the imaging of haematomas within 24 h of onset and in subarachnoid haemorrhage computed tomography is the investigation of choice. 13 refs., 6 figs

  20. Imaging system for creating 3D block-face cryo-images of whole mice

    Science.gov (United States)

    Roy, Debashish; Breen, Michael; Salvado, Olivier; Heinzel, Meredith; McKinley, Eliot; Wilson, David

    2006-03-01

    We developed a cryomicrotome/imaging system that provides high resolution, high sensitivity block-face images of whole mice or excised organs, and applied it to a variety of biological applications. With this cryo-imaging system, we sectioned cryo-preserved tissues at 2-40 μm thickness and acquired high resolution brightfield and fluorescence images with microscopic in-plane resolution (as good as 1.2 μm). Brightfield images of normal and pathological anatomy show exquisite detail, especially in the abdominal cavity. Multi-planar reformatting and 3D renderings allow one to interrogate 3D structures. In this report, we present brightfield images of mouse anatomy, as well as 3D renderings of organs. For BPK mice model of polycystic kidney disease, we compared brightfield cryo-images and kidney volumes to MRI. The color images provided greater contrast and resolution of cysts as compared to in vivo MRI. We note that color cryo-images are closer to what a researcher sees in dissection, making it easier for them to interpret image data. The combination of field of view, depth of field, ultra high resolution and color/fluorescence contrast enables cryo-image volumes to provide details that cannot be found through in vivo imaging or other ex vivo optical imaging approaches. We believe that this novel imaging system will have applications that include identification of mouse phenotypes, characterization of diseases like blood vessel disease, kidney disease, and cancer, assessment of drug and gene therapy delivery and efficacy and validation of other imaging modalities.

  1. Impact of amyloid-beta changes on cognitive outcomes in Alzheimer's disease: analysis of clinical trials using a quantitative systems pharmacology model.

    Science.gov (United States)

    Geerts, Hugo; Spiros, Athan; Roberts, Patrick

    2018-02-02

    Despite a tremendous amount of information on the role of amyloid in Alzheimer's disease (AD), almost all clinical trials testing this hypothesis have failed to generate clinically relevant cognitive effects. We present an advanced mechanism-based and biophysically realistic quantitative systems pharmacology computer model of an Alzheimer-type neuronal cortical network that has been calibrated with Alzheimer Disease Assessment Scale, cognitive subscale (ADAS-Cog) readouts from historical clinical trials and simulated the differential impact of amyloid-beta (Aβ40 and Aβ42) oligomers on glutamate and nicotinic neurotransmission. Preclinical data suggest a beneficial effect of shorter Aβ forms within a limited dose range. Such a beneficial effect of Aβ40 on glutamate neurotransmission in human patients is absolutely necessary to reproduce clinical data on the ADAS-Cog in minimal cognitive impairment (MCI) patients with and without amyloid load, the effect of APOE genotype effect on the slope of the cognitive trajectory over time in placebo AD patients and higher sensitivity to cholinergic manipulation with scopolamine associated with higher Aβ in MCI subjects. We further derive a relationship between units of Aβ load in our model and the standard uptake value ratio from amyloid imaging. When introducing the documented clinical pharmacodynamic effects on Aβ levels for various amyloid-related clinical interventions in patients with low Aβ baseline, the platform predicts an overall significant worsening for passive vaccination with solanezumab, beta-secretase inhibitor verubecestat and gamma-secretase inhibitor semagacestat. In contrast, all three interventions improved cognition in subjects with moderate to high baseline Aβ levels, with verubecestat anticipated to have the greatest effect (around ADAS-Cog value 1.5 points), solanezumab the lowest (0.8 ADAS-Cog value points) and semagacestat in between. This could explain the success of many amyloid

  2. A combination chaotic system and application in color image encryption

    Science.gov (United States)

    Parvaz, R.; Zarebnia, M.

    2018-05-01

    In this paper, by using Logistic, Sine and Tent systems we define a combination chaotic system. Some properties of the chaotic system are studied by using figures and numerical results. A color image encryption algorithm is introduced based on new chaotic system. Also this encryption algorithm can be used for gray scale or binary images. The experimental results of the encryption algorithm show that the encryption algorithm is secure and practical.

  3. Implementation of a program of quality assurance of image in an imaging system of flat panel portal

    International Nuclear Information System (INIS)

    Gomez Barrado, A.; Sanchez Jimenez, E.; Benitez, J. A.; Sanchez-Reyes, A.

    2013-01-01

    (IGRT) image-guided radiation therapy is the one in which images are used to locate the area of treatment. Modern irradiation systems are equipped with different modalities for obtaining images, such as flat panel systems, systems conebeam, tomoimagen, etc. This paper describes the start-up and the experience of a quality assurance program based on a flat panel portal Imaging System. (Author)

  4. Design of CMOS imaging system based on FPGA

    Science.gov (United States)

    Hu, Bo; Chen, Xiaolai

    2017-10-01

    In order to meet the needs of engineering applications for high dynamic range CMOS camera under the rolling shutter mode, a complete imaging system is designed based on the CMOS imaging sensor NSC1105. The paper decides CMOS+ADC+FPGA+Camera Link as processing architecture and introduces the design and implementation of the hardware system. As for camera software system, which consists of CMOS timing drive module, image acquisition module and transmission control module, the paper designs in Verilog language and drives it to work properly based on Xilinx FPGA. The ISE 14.6 emulator ISim is used in the simulation of signals. The imaging experimental results show that the system exhibits a 1280*1024 pixel resolution, has a frame frequency of 25 fps and a dynamic range more than 120dB. The imaging quality of the system satisfies the requirement of the index.

  5. Enhancement system of nighttime infrared video image and visible video image

    Science.gov (United States)

    Wang, Yue; Piao, Yan

    2016-11-01

    Visibility of Nighttime video image has a great significance for military and medicine areas, but nighttime video image has so poor quality that we can't recognize the target and background. Thus we enhance the nighttime video image by fuse infrared video image and visible video image. According to the characteristics of infrared and visible images, we proposed improved sift algorithm andαβ weighted algorithm to fuse heterologous nighttime images. We would deduced a transfer matrix from improved sift algorithm. The transfer matrix would rapid register heterologous nighttime images. And theαβ weighted algorithm can be applied in any scene. In the video image fusion system, we used the transfer matrix to register every frame and then used αβ weighted method to fuse every frame, which reached the time requirement soft video. The fused video image not only retains the clear target information of infrared video image, but also retains the detail and color information of visible video image and the fused video image can fluency play.

  6. Exploratory survey of image quality on CR digital mammography imaging systems in Mexico

    International Nuclear Information System (INIS)

    Gaona, E.; Rivera, T.; Arreola, M.; Franco, J.; Molina, N.; Alvarez, B.; Azorín, C.G.; Casian, G.

    2014-01-01

    The purpose of this study was to assess the current status of image quality and dose in computed radiographic digital mammography (CRDM) systems. Studies included CRDM systems of various models and manufacturers which dose and image quality comparisons were performed. Due to the recent rise in the use of digital radiographic systems in Mexico, CRDM systems are rapidly replacing conventional film-screen systems without any regard to quality control or image quality standards. Study was conducted in 65 mammography facilities which use CRDM systems in the Mexico City and surrounding States. The systems were tested as used clinically. This means that the dose and beam qualities were selected using the automatic beam selection and photo-timed features. All systems surveyed generate laser film hardcopies for the radiologist to read on a scope or mammographic high luminance light box. It was found that 51 of CRDM systems presented a variety of image artefacts and non-uniformities arising from inadequate acquisition and processing, as well as from the laser printer itself. Undisciplined alteration of image processing settings by the technologist was found to be a serious prevalent problem in 42 facilities. Only four of them showed an image QC program which is periodically monitored by a medical physicist. The Average Glandular Dose (AGD) in the surveyed systems was estimated to have a mean value of 2.4 mGy. To improve image quality in mammography and make more efficient screening mammographic in early detection of breast cancer is required new legislation. - Highlights: • Radiation dose in CR digital mammography (CRDM) systems was determined. • Image quality related with dose in CR digital mammography (CRDM) systems was analysed. • Image processing artefacts were observed and correlated with dose. • Measured entrance dose by TL phosphors could be good parameter for radiation protection optimization in patient

  7. Imaging opiate receptors by positron tomography (PET): Evaluation by displacement of 3-Acetyl-6-Deoxy-6-Beta-/sup 18/F-flouronaltrexone with active and inactive naloxone

    International Nuclear Information System (INIS)

    Larson, S.M.; Channing, M.A.; Rice, K.R.; Pert, C.B.; Eckelman, W.C.; Burke, T.R.; Bennett, J.M.; Carson, R.E.; Di Chiro, G.

    1985-01-01

    We recently reported the development of a new radiopharmaceutical for in vivo PET imaging of opiate receptors, 3-acetyl-6-deoxy-6-Beta-/sup 18/F-fluoronaltrexone: 3-acetylcyclofoxy, or /sup 18/F-ACF. These studies involved displacement of /sup 18/F-ACF from sites of uptake in the baboon sub-cortical gray matter, and provided strong proof of the opiate receptor specificity of the tracer. We now report on the anatomic localization of /sup 18/F-ACF in the sub-cortical grapy matter of baboon, and the kinetics of uptake and displacement of the tracer. /sup 18/F-ACF was prepared from the known 3-acetyl-6-alpha-naltrexol via the triflate, using /sup 18/F produced by neutron bombardment of /sup 6/Li/sub 2/CO/sub 3/. Anesthetized baboons were imaged after injection of /sup 18/F-ACF (sp.ac.=20Ci/mmol), using the NIH NEUROPET, a high resolution PET scanner. After bolus injection, the initial distribution to brain was rapid with peak uptake at 6 minutes post-injection. Clearance from opiate receptor rich regions of thalamus and basal ganglia was gradual, but after injection of active (but not after inactive), naloxone, clearance from these regions more than doubled. In non-opiate rich regions, (e.g. cerebellum), the predominant component of clearance was equally rapid with or without the active naloxone. Displacement studies of positron labelled ligands provide a powerful tool for non-invasive study of opiate receptor in living primates

  8. Ethnic comparison of pharmacokinetics of {sup 18}F-florbetaben, a PET tracer for beta-amyloid imaging, in healthy Caucasian and Japanese subjects

    Energy Technology Data Exchange (ETDEWEB)

    Senda, Michio; Sasaki, Masahiro; Yamane, Tomohiko; Shimizu, Keiji [Institute of Biomedical Research and Innovation, Division of Molecular Imaging, 2-2 Minatojima-Minamimachi, Chuo-ku, Kobe (Japan); Patt, Marianne; Barthel, Henryk; Sattler, Bernhard; Sabri, Osama [University of Leipzig, Department of Nuclear Medicine, Leipzig (Germany); Nagasawa, Toshiki; Aitoku, Yasuko [Bayer Yakuhin Ltd, Osaka (Japan); Schultze-Mosgau, Marcus [Bayer HealthCare AG, Berlin (Germany); Dinkelborg, Ludger [Piramal Imaging GmbH, Berlin (Germany)

    2015-01-15

    {sup 18}F-Florbetaben is a positron emission tomography (PET) tracer indicated for imaging cerebral beta-amyloid deposition in adult patients with cognitive impairment who are being evaluated for Alzheimer's disease and other causes of cognitive decline. The present study examined ethnic comparability of the plasma pharmacokinetics, which is the input to the brain, between Caucasian and Japanese subjects. Two identical phase I trials were performed in 18 German and 18 Japanese healthy volunteers to evaluate the plasma pharmacokinetics of a single dose of 300 MBq {sup 18}F-florbetaben, either of low (≤5 μg, LD) or high (50-55 μg, HD) mass dose. Pharmacokinetic parameters were evaluated based on the total {sup 18}F radioactivity measurements in plasma followed by metabolite analysis using radio-HPLC. The pharmacokinetics of {sup 18}F-florbetaben was characterized by a rapid elimination from plasma. The dose-normalized areas under the curve of {sup 18}F-florbetaben in plasma as an indicator of the input to the brain were comparable between Germans (LD: 0.38 min/l, HD: 0.55 min/l) and Japanese (LD: 0.35 min/l, HD: 0.45 min/l) suggesting ethnic similarity, and the mass dose effect was minimal. A polar metabolite fraction was the main radiolabelled degradation product in plasma and was also similar between the doses and the ethnic groups. Absence of a difference in the pharmacokinetics of {sup 18}F-florbetaben in Germans and Japanese has warranted further global development of the PET imaging agent. (orig.)

  9. Stepped scanner radiographic imaging system using edge blending

    International Nuclear Information System (INIS)

    Lapidus, S.N.

    1984-01-01

    An imaging system is described which includes a radiographic camera, a bed for supporting a subject in view of the camera, and a display system. The camera provides X and Y coordinate signals for each radiographic event. The position of the bed relative to the camera is altered stepwise and a sequence of images is provided by the camera each image being positioned on a display system in correspondence with the location of the bed relative to the camera. The camera is electronically decoupled from the display by a gate during movement of the bed relative to the camera from one location to the next location to prevent any smearing effect within the composite image presented on the display. The edges of contiguous images making up the composite image are blended by electronically adjusting their boundary regions so as to provide overlapping or interlocking. (author)

  10. Television imaging system for fast neutron radiography using baby cyclotron

    International Nuclear Information System (INIS)

    Yoshii, Koji; Miya, Kenzo; Katoh, Norihiko.

    1993-01-01

    A television imaging system for fast neutron radiography (FNR-TV) developed using the fast neutron source reactor YAYOI was applied to the baby-cyclotron based fast neutron source to get images of thick objects quickly. In the system the same technique as a current television imaging system of thermal neutron radiography was applied, while the luminescent converter was used to detect fast neutrons. Using the CR39 track etch method it took about 7 h to get an image, while the FNR-TV only 20 s enough for taking the same object. However the FNR-TV imaging result of the simulation model of a large explosive device for the space launch vehicle of H-2 type was not so good as the image taken with the CR39 track etch method. The reason was that the luminescence intensity of the FNR-TV converter was a quarter of that in the YAYOI. (author)

  11. Advanced imaging of skeletal manifestations of systemic mastocytosis

    International Nuclear Information System (INIS)

    Fritz, J.; Fishman, E.K.; Carrino, J.A.; Horger, M.S.

    2012-01-01

    Systemic mastocytosis comprises a group of clonal disorders of the mast cell that most commonly involves the skeletal system. Imaging can be helpful in the detection and characterization of the osseous manifestations of this disease. While radiography and bone scans are frequently used for this assessment, low-dose multidetector computed tomography and magnetic resonance imaging can be more sensitive for the detection of marrow involvement and for the demonstration of the various disease patterns. In this article, we review the pathophysiological and clinical features of systemic mastocytosis, discuss the role of imaging for staging and management, and illustrate the various cross-sectional imaging appearances. Awareness and knowledge of the imaging features of this disorder will increase the accuracy of image interpretation and can contribute important information for management decisions. (orig.)

  12. Advanced imaging of skeletal manifestations of systemic mastocytosis

    Energy Technology Data Exchange (ETDEWEB)

    Fritz, J. [Johns Hopkins University School of Medicine, Russell H. Morgan Department of Radiology and Radiological Science, Baltimore, MD (United States); Fishman, E.K.; Carrino, J.A. [Johns Hopkins University School of Medicine, Russell H. Morgan Department of Radiology and Radiological Science, Baltimore, MD (United States); Horger, M.S. [Eberhard-Karls-University, Department of Diagnostic and Interventional Radiology, Tuebingen (Germany)

    2012-08-15

    Systemic mastocytosis comprises a group of clonal disorders of the mast cell that most commonly involves the skeletal system. Imaging can be helpful in the detection and characterization of the osseous manifestations of this disease. While radiography and bone scans are frequently used for this assessment, low-dose multidetector computed tomography and magnetic resonance imaging can be more sensitive for the detection of marrow involvement and for the demonstration of the various disease patterns. In this article, we review the pathophysiological and clinical features of systemic mastocytosis, discuss the role of imaging for staging and management, and illustrate the various cross-sectional imaging appearances. Awareness and knowledge of the imaging features of this disorder will increase the accuracy of image interpretation and can contribute important information for management decisions. (orig.)

  13. Imaging systems and methods for obtaining and using biometric information

    Science.gov (United States)

    McMakin, Douglas L [Richland, WA; Kennedy, Mike O [Richland, WA

    2010-11-30

    Disclosed herein are exemplary embodiments of imaging systems and methods of using such systems. In one exemplary embodiment, one or more direct images of the body of a clothed subject are received, and a motion signature is determined from the one or more images. In this embodiment, the one or more images show movement of the body of the subject over time, and the motion signature is associated with the movement of the subject's body. In certain implementations, the subject can be identified based at least in part on the motion signature. Imaging systems for performing any of the disclosed methods are also disclosed herein. Furthermore, the disclosed imaging, rendering, and analysis methods can be implemented, at least in part, as one or more computer-readable media comprising computer-executable instructions for causing a computer to perform the respective methods.

  14. Development of an integrated filing system for endoscopic images.

    Science.gov (United States)

    Fujino, M A; Ikeda, M; Yamamoto, Y; Kinose, T; Tachikawa, H; Morozumi, A; Sano, S; Kojima, Y; Nakamura, T; Kawai, T

    1991-01-01

    A new integrated filing system for endoscopic images has been developed, comprising a main image filing system and subsystems located at different stations. A hybrid filing system made up of both digital and analog filing devices was introduced to construct this system that combines the merits of the two filing methods. Each subsystem provided with a video processor, is equipped with a digital filing device, and routine images were recorded in the analog image filing device of the main system. The use of a multi-input adapter enabled simultaneous input of analog images from up to 8 video processors. Recorded magneto-optical disks make it possible to recall the digital images at any station in the hospital; the disks are copied without image degradation and also utilised for image processing. This system promises reliable storage and integrated, efficient management of endoscopic information. It also costs less to install than the so-called PACS (picture archiving and communication system), which connects all the stations of the hospital using optical fiber cables.

  15. Development of a combination detector system for simultaneous measurement of Alpha and Beta/Gamma radioactivity

    International Nuclear Information System (INIS)

    Thakur, Vaishali M.; Ashokkumar, P.; Rekha, A.K.; Jain, Amit; Rath, D.P.; Chaudhury, Probal; Chaudhari, L.M.

    2018-01-01

    Analysis of various samples for α and β/γ radioactivity is carried out in radiological laboratories. Using independent α and β/γ counting systems such measurements are done separately for same sample. In order to address the requirement of simultaneous measurement of α and β/γ activity content of radioactive samples, a counting system using combination of two detectors has been developed. Activity deposited on a 2 mm deep 30 mm diameter aluminum planchette was counted under the detector combination consisting of a ZnS(Ag) and plastic scintillator for α and β/γ respectively. The design and fabrication of the combination detector, development of electronics associated with the system, its characterization and application are presented here

  16. Stokes image reconstruction for two-color microgrid polarization imaging systems.

    Science.gov (United States)

    Lemaster, Daniel A

    2011-07-18

    The Air Force Research Laboratory has developed a new microgrid polarization imaging system capable of simultaneously reconstructing linear Stokes parameter images in two colors on a single focal plane array. In this paper, an effective method for extracting Stokes images is presented for this type of camera system. It is also shown that correlations between the color bands can be exploited to significantly increase overall spatial resolution. Test data is used to show the advantages of this approach over bilinear interpolation. The bounds (in terms of available reconstruction bandwidth) on image resolution are also provided.

  17. On the Computational Complexity of the Languages of General Symbolic Dynamical Systems and Beta-Shifts

    DEFF Research Database (Denmark)

    Simonsen, Jakob Grue

    2009-01-01

    We consider the computational complexity of languages of symbolic dynamical systems. In particular, we study complexity hierarchies and membership of the non-uniform class P/poly. We prove: 1.For every time-constructible, non-decreasing function t(n)=@w(n), there is a symbolic dynamical system...... with language decidable in deterministic time O(n^2t(n)), but not in deterministic time o(t(n)). 2.For every space-constructible, non-decreasing function s(n)=@w(n), there is a symbolic dynamical system with language decidable in deterministic space O(s(n)), but not in deterministic space o(s(n)). 3.There...... are symbolic dynamical systems having hard and complete languages under @?"m^l^o^g^s- and @?"m^p-reduction for every complexity class above LOGSPACE in the backbone hierarchy (hence, P-complete, NP-complete, coNP-complete, PSPACE-complete, and EXPTIME-complete sets). 4.There are decidable languages of symbolic...

  18. BIOACCUMULATION AND AQUATIC SYSTEM SIMULATOR (BASS) USER'S MANUAL BETA TEST VERSION 2.1

    Science.gov (United States)

    BASS (Bioaccumulation and Aquatic System Simulator) is a Fortran 95 simulation program that predicts the population and bioaccumulation dynamics of age-structured fish assemblages that are exposed to hydrophobic organic pollutants and class B and borderline metals that complex wi...

  19. Effect of beta-adrenergic blockade on elevated arterial compliance and low systemic vascular resistance in cirrhosis

    DEFF Research Database (Denmark)

    Møller, Søren; Bendtsen, Flemming; Henriksen, Jens Henrik

    2001-01-01

    with beta-blockers, but the effect of this treatment on arterial compliance has not been investigated. The aim of the present study was therefore to assess the effects of propranolol on the arterial compliance of patients with cirrhosis. METHODS: Twenty patients with cirrhosis underwent a haemodynamic......) of 17.8 mmHg, and responded to beta-blocker treatment with a significant reduction in the HVPG (-16%; P beta-adrenergic blockade (1.27 versus 1.29 ml/mmHg, +2%, ns), whereas...... with beta-blockers increases small vessel (arteriolar) vascular tone towards the normal level, but does not affect the elevated compliance of the larger arteries in patients with cirrhosis....

  20. Development of computed tomography system and image reconstruction algorithm

    International Nuclear Information System (INIS)

    Khairiah Yazid; Mohd Ashhar Khalid; Azaman Ahmad; Khairul Anuar Mohd Salleh; Ab Razak Hamzah

    2006-01-01

    Computed tomography is one of the most advanced and powerful nondestructive inspection techniques, which is currently used in many different industries. In several CT systems, detection has been by combination of an X-ray image intensifier and charge -coupled device (CCD) camera or by using line array detector. The recent development of X-ray flat panel detector has made fast CT imaging feasible and practical. Therefore this paper explained the arrangement of a new detection system which is using the existing high resolution (127 μm pixel size) flat panel detector in MINT and the image reconstruction technique developed. The aim of the project is to develop a prototype flat panel detector based CT imaging system for NDE. The prototype consisted of an X-ray tube, a flat panel detector system, a rotation table and a computer system to control the sample motion and image acquisition. Hence this project is divided to two major tasks, firstly to develop image reconstruction algorithm and secondly to integrate X-ray imaging components into one CT system. The image reconstruction algorithm using filtered back-projection method is developed and compared to other techniques. The MATLAB program is the tools used for the simulations and computations for this project. (Author)

  1. RANZAR Body Systems Framework of diagnostic imaging examination descriptors

    International Nuclear Information System (INIS)

    Pitman, Alexander D.; Penlington, Lisa; Doromal, Darren; Vukolova, Natalia; Slater, Gregory

    2014-01-01

    A unified and logical system of descriptors for diagnostic imaging examinations and procedures is a desirable resource for radiology in Australia and New Zealand and is needed to support core activities of RANZCR. Existing descriptor systems available in Australia and New Zealand (including the Medicare DIST and the ACC Schedule) have significant limitations and are inappropriate for broader clinical application. An anatomically based grid was constructed, with anatomical structures arranged in rows and diagnostic imaging modalities arranged in columns (including nuclear medicine and positron emission tomography). The grid was segregated into five body systems. The cells at the intersection of an anatomical structure row and an imaging modality column were populated with short, formulaic descriptors of the applicable diagnostic imaging examinations. Clinically illogical or physically impossible combinations were ‘greyed out’. Where the same examination applied to different anatomical structures, the descriptor was kept identical for the purposes of streamlining. The resulting Body Systems Framework of diagnostic imaging examination descriptors lists all the reasonably common diagnostic imaging examinations currently performed in Australia and New Zealand using a unified grid structure allowing navigation by both referrers and radiologists. The Framework has been placed on the RANZCR website and is available for access free of charge by registered users. The Body Systems Framework of diagnostic imaging examination descriptors is a system of descriptors based on relationships between anatomical structures and imaging modalities. The Framework is now available as a resource and reference point for the radiology profession and to support core College activities.

  2. Magnetic resonance imaging in multiple system atrophy

    Energy Technology Data Exchange (ETDEWEB)

    Aotsuka, Akiyo; Shinotoh, Hitoshi; Hirayama, Keizo [Chiba Univ. (Japan). School of Medicine; Ikehira, Hiroo; Hashimoto, Takahiro

    1992-08-01

    We studied 18 patients with multiple system atrophy (MSA) by high field strength MRI: 6 striatonigral degeneration (SND), 4 Shy-Drager syndrome (SDS), and 8 olivo-ponto-cerebellar atrophy (OPCA). We also studied 30 Parkinson's disease (PD) and 10 age-matched controls. The diagnosis of SND, SDS, and OPCA were based on criteria after Hirayama et al (1985). Bradykinesia, rigidity, and tremor were assessed with the summed scores of the signs used as the extrapyramidal scores. The mean extrapyramidal scores were not significantly different in patients with SND, SDS, OPCA, and PD. MRI studies were performed on 1.5 tesla MRI unit, using a T[sub 2]-weighted spin echo pulse sequence (TR2500 ms/TE40 ms). The width of the pars compacta signal in all subjects was measured by the method of Duguid et al (1986). Intensity profiles were made on a straight line perpendicular to the pars compacta through the center of the red nucleus on an image of the midbrain. We measured the width of the valley at half-height between the peaks of an index of the width of the pars compacta signal. The mean widths of the pars compacta signal were: 2.8[+-]0.4 mm (SND), 2.8[+-]0.7 mm (SDS), 3.6[+-]0.6 mm (OPCA), 2.7[+-]0.3 mm (PD), and 4.3[+-]0.6 mm (control). The mean widths of the pars compacta signal in PD, SND, and SDS were significantly narrower than that in the control group (p<0.05), while the OPCA group was not significantly narrower. The results may indicate that the time course of nigral involvement is milder in OPCA than in SND and SDS. The extrapyramidal signs in OPCA may be attributed mainly to the degeneration of the putamen rather than to that of the substantia nigra. Abnormal hypointensity in the posterolateral putamen was found in only one SND patient and in two OPCA patients, even though this finding has been frequently observed in MSA. Since no PD patients exhibited this finding, it may of some value in differentiating MSA from PD. (author).

  3. [The Role of Imaging in Central Nervous System Infections].

    Science.gov (United States)

    Yokota, Hajime; Tazoe, Jun; Yamada, Kei

    2015-07-01

    Many infections invade the central nervous system. Magnetic resonance imaging (MRI) is the main tool that is used to evaluate infectious lesions of the central nervous system. The useful sequences on MRI are dependent on the locations, such as intra-axial, extra-axial, and spinal cord. For intra-axial lesions, besides the fundamental sequences, including T1-weighted images, T2-weighted images, and fluid-attenuated inversion recovery (FLAIR) images, advanced sequences, such as diffusion-weighted imaging, diffusion tensor imaging, susceptibility-weighted imaging, and MR spectroscopy, can be applied. They are occasionally used as determinants for quick and correct diagnosis. For extra-axial lesions, understanding the differences among 2D-conventional T1-weighted images, 2D-fat-saturated T1-weighted images, 3D-Spin echo sequences, and 3D-Gradient echo sequence after the administration of gadolinium is required to avoid wrong interpretations. FLAIR plus gadolinium is a useful tool for revealing abnormal enhancement on the brain surface. For the spinal cord, the sequences are limited. Evaluating the distribution and time course of the spinal cord are essential for correct diagnoses. We summarize the role of imaging in central nervous system infections and show the pitfalls, key points, and latest information in them on clinical practices.

  4. A photoacoustic tomography system for imaging of biological tissues

    International Nuclear Information System (INIS)

    Su Yixiong; Zhang Fan; Xu Kexin; Yao Jianquan; Wang, Ruikang K

    2005-01-01

    Non-invasive laser-induced photoacoustic tomography (PAT) is a promising imaging modality in the biomedical optical imaging field. This technology, based on the intrinsic optical properties of tissue and ultrasonic detection, overcomes the resolution disadvantage of pure-optical imaging caused by strong light scattering and the contrast and speckle disadvantages of pure ultrasonic imaging. Here, we report a PAT experimental system constructed in our laboratory. In our system, a Q-switched Nd : YAG pulse laser operated at 532 nm with a 8 ns pulse width is used to generate a photoacoustic signal. By using this system, the two-dimensional distribution of optical absorption in the tissue-mimicking phantom is reconstructed and has an excellent agreement with the original ones. The spatial resolution of the imaging system approaches 100 μm through about 4 cm of highly scattering medium

  5. ORIS: the Oak Ridge Imaging System program listings

    International Nuclear Information System (INIS)

    Bell, P.R.; Dougherty, J.M.

    1978-04-01

    The Oak Ridge Imaging System (ORIS) is a general purpose access, storage, processing and display system for nuclear medicine imaging with rectilinear scanner and gamma camera. This volume contains listings of the PDP-8/E version of ORIS Version 2. The system is designed to run under the Digital Equipment Corporation's OS/8 monitor in 16K or more words of core. System and image file mass storage is on RK8E disk; longer-time image file storage is provided on DECtape. Another version of this program exists for use with the RF08 disk, and a more limited version is for DECtape only. This latter version is intended for non-medical imaging

  6. Improvement of a Vocal Fold Imaging System

    Energy Technology Data Exchange (ETDEWEB)

    Krauter, K. G. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-02-01

    Medical professionals can better serve their patients through continual update of their imaging tools. A wide range of pathologies and disease may afflict human vocal cords or, as they’re also known, vocal folds. These diseases can affect human speech hampering the ability of the patient to communicate. Vocal folds must be opened for breathing and the closed to produce speech. Currently methodologies to image markers of potential pathologies are difficult to use and often fail to detect early signs of disease. These current methodologies rely on a strobe light and slower frame rate camera in an attempt to obtain images as the vocal folds travel over the full extent of their motion.

  7. Potassium analysis by beta counting using a Geiger-Mueller system

    International Nuclear Information System (INIS)

    Espana, E.; Beneitez, P.; Calderon, T.

    1993-01-01

    A technique for quantitative analysis of different soils, ceramics, feldspars and natural halide samples is presented, based on the measurement of β-activities using a Geiger-Mueller system. The system was calibrated with KCl, KC 8 H 5 O 4 , KNO 3 and K 2 SO 4 standards and a potassium content of 1% yields a net β-count rate (background subtracted) of about 55 cph. Precision values of less than ±0.4% K can be achieved in counting times of about 4 hours. The results agree with those obtained by means of other more common analytical methods such as flame photometry, atomic absorption and γ-spectrometry. In comparison with these methods, this approach is direct, precise and non-destructive, because the samples do not require prior treatment. (author) 16 refs.; 2 figs.; 6 tabs

  8. Critical Analysis on Characterization, Systemic Effect, and Therapeutic Potential of Beta-Sitosterol: A Plant-Derived Orphan Phytosterol

    Directory of Open Access Journals (Sweden)

    Muhammad Shahdaat Bin Sayeed

    2016-11-01

    Full Text Available Beta-sitosterol (BS is a phytosterol, widely distributed throughout the plant kingdom and known to be involved in the stabilization of cell membranes. To compile the sources, physical and chemical properties, spectral and chromatographic analytical methods, synthesis, systemic effects, pharmacokinetics, therapeutic potentials, toxicity, drug delivery and finally, to suggest future research with BS, classical as well as on-line literature were studied. Classical literature includes classical books on ethnomedicine and phytochemistry, and the electronic search included Pubmed, SciFinder, Scopus, the Web of Science, Google Scholar, and others. BS could be obtained from different plants, but the total biosynthetic pathway, as well as its exact physiological and structural function in plants, have not been fully understood. Different pharmacological effects have been studied, but most of the mechanisms of action have not been studied in detail. Clinical trials with BS have shown beneficial effects in different diseases, but long-term study results are not available. These have contributed to its current status as an “orphan phytosterol”. Therefore, extensive research regarding its effect at cellular and molecular level in humans as well as addressing the claims made by commercial manufacturers such as the cholesterol lowering ability, immunological activity etc. are highly recommended.

  9. THE SEEDS DIRECT IMAGING SURVEY FOR PLANETS AND SCATTERED DUST EMISSION IN DEBRIS DISK SYSTEMS

    Energy Technology Data Exchange (ETDEWEB)

    Janson, Markus; Brandt, Timothy D. [Department of Astrophysical Sciences, Princeton University, NJ 08544 (United States); Moro-Martin, Amaya [Department of Astrophysics, CAB (INTA-CSIC), Instituto Nacional de Tecnica Aerospacial, Torrejonde Ardoz, E-28850 Madrid (Spain); Usuda, Tomonori; Kudo, Tomoyuki; Egner, Sebastian [Subaru Telescope, 650 North Aohoku Place, Hilo, HI 96720 (United States); Thalmann, Christian [Astronomical Institute ' ' Anton Pannekoek' ' , University of Amsterdam, Science Park 904, 1098-XH Amsterdam (Netherlands); Carson, Joseph C. [Department of Physics and Astronomy, College of Charleston, 58 Coming Street, Charleston, SC 29424 (United States); Goto, Miwa [Universitaets-Sternwarte Muenchen, Ludwig-Maximilians-Universitaet, Scheinerstr. 1, D-81679 Munich (Germany); Currie, Thayne [Department of Astronomy and Astrophysics, University of Toronto, 50 St. George Street, M5S 3H4 Toronto, ON (Canada); McElwain, M. W. [Exoplanets and Stellar Astrophysics Laboratory, Code 667, Goddard Space Flight Center, Greenbelt, MD 2071 (United States); Itoh, Yoichi [Nishi-Harima Astronomical Observatory, Center for Astronomy, University of Hyogo, 407-2 Nishigaichi, Sayo, Hyogo 679-5313 (Japan); Fukagawa, Misato [Department of Earth and Space Science, Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043 (Japan); Crepp, Justin [Department of Physics, University of Notre Dame, 225 Nieuwland Science Hall, Notre Dame, IN 46556 (United States); Kuzuhara, Masayuki; Hashimoto, Jun; Kusakabe, Nobuhiko [National Astronomical Observatory of Japan, 2-21-1 Osawa, Mitaka, Tokyo 181-8588 (Japan); Abe, Lyu [Laboratoire Lagrange, UMR7239, University of Nice-Sophia Antipolis, CNRS, Observatoire de la Cote d' Azur, F-06300 Nice (France); Brandner, Wolfgang; Feldt, Markus, E-mail: janson@astro.princeton.edu [Max Planck Institute for Astronomy, Koenigstuhl 17, D-69117 Heidelberg (Germany); and others

    2013-08-10

    Debris disks around young main-sequence stars often have gaps and cavities which for a long time have been interpreted as possibly being caused by planets. In recent years, several giant planet discoveries have been made in systems hosting disks of precisely this nature, further implying that interactions with planets could be a common cause of such disk structures. As part of the SEEDS high-contrast imaging survey, we are surveying a population of debris-disk-hosting stars with gaps and cavities implied by their spectral energy distributions, in order to attempt to spatially resolve the disk as well as to detect any planets that may be responsible for the disk structure. Here, we report on intermediate results from this survey. Five debris disks have been spatially resolved, and a number of faint point sources have been discovered, most of which have been tested for common proper motion, which in each case has excluded physical companionship with the target stars. From the detection limits of the 50 targets that have been observed, we find that {beta} Pic b-like planets ({approx}10 M{sub jup} planets around G-A-type stars) near the gap edges are less frequent than 15%-30%, implying that if giant planets are the dominant cause of these wide (27 AU on average) gaps, they are generally less massive than {beta} Pic b.

  10. Hyperspectral imaging system for disease scanning on banana plants

    Science.gov (United States)

    Ochoa, Daniel; Cevallos, Juan; Vargas, German; Criollo, Ronald; Romero, Dennis; Castro, Rodrigo; Bayona, Oswaldo

    2016-05-01

    Black Sigatoka (BS) is a banana plant disease caused by the fungus Mycosphaerella fijiensis. BS symptoms can be observed at late infection stages. By that time, BS has probably spread to other plants. In this paper, we present our current work on building an hyper-spectral (HS) imaging system aimed at in-vivo detection of BS pre-symptomatic responses in banana leaves. The proposed imaging system comprises a motorized stage, a high-sensitivity VIS-NIR camera and an optical spectrograph. To capture images of the banana leaf, the stage's speed and camera's frame rate must be computed to reduce motion blur and to obtain the same resolution along both spatial dimensions of the resulting HS cube. Our continuous leaf scanning approach allows imaging leaves of arbitrary length with minimum frame loss. Once the images are captured, a denoising step is performed to improve HS image quality and spectral profile extraction.

  11. Diagnostic information management system for the evaluation of medical images

    Energy Technology Data Exchange (ETDEWEB)

    Higa, Toshiaki; Torizuka, Kanji; Minato, Kotaro; Komori, Masaru; Hirakawa, Akina

    1985-04-01

    A practical, small and low-cost diagnostic information management system has been developed for a comparative study of various medical imaging procedures, including ordinary radiography, X-ray computed tomography, emission computed tomography, and so forth. The purpose of the system is to effectively manage the original image data files and diagnostic descriptions during the various imaging procedures. A diagnostic description of each imaging procedure for each patient is made on a hand-sort punched-card with line-drawings and ordinary medical terminology and then coded and computerized using Index for Roentgen Diagnoses (American College of Radiology). A database management software (DB Master) on a personal computer (Apple II) is used for searching for patients' records on hand-sort punched-cards and finally original medical images. Discussed are realistic use of medical images and an effective form of diagnostic descriptions.

  12. Diagnostic information management system for the evaluation of medical images

    International Nuclear Information System (INIS)

    Higa, Toshiaki; Torizuka, Kanji; Minato, Kotaro; Komori, Masaru; Hirakawa, Akina.

    1985-01-01

    A practical, small and low-cost diagnostic information management system has been developed for a comparative study of various medical imaging procedures, including ordinary radiography, X-ray computed tomography, emission computed tomography, and so forth. The purpose of the system is to effectively manage the original image data files and diagnostic descriptions during the various imaging procedures. A diagnostic description of each imaging procedure for each patient is made on a hand-sort punched-card with line-drawings and ordinary medical terminology and then coded and computerized using Index for Roentgen Diagnoses (American College of Radiology). A database management software (DB Master) on a personal computer (Apple II) is used for searching for patients' records on hand-sort punched-cards and finally original medical images. Discussed are realistic use of medical images and an effective form of diagnostic descriptions. (author)

  13. Advanced digital image archival system using MPEG technologies

    Science.gov (United States)

    Chang, Wo

    2009-08-01

    Digital information and records are vital to the human race regardless of the nationalities and eras in which they were produced. Digital image contents are produced at a rapid pace from cultural heritages via digitalization, scientific and experimental data via high speed imaging sensors, national defense satellite images from governments, medical and healthcare imaging records from hospitals, personal collection of photos from digital cameras. With these mass amounts of precious and irreplaceable data and knowledge, what standards technologies can be applied to preserve and yet provide an interoperable framework for accessing the data across varieties of systems and devices? This paper presents an advanced digital image archival system by applying the international standard of MPEG technologies to preserve digital image content.

  14. Results from a 64-pixel PIN-diode detector system for low-energy beta-electrons

    Energy Technology Data Exchange (ETDEWEB)

    Wuestling, Sascha, E-mail: sascha.wuestling@kit.ed [Forschungszentrum Karlsruhe, Institut fuer Prozessdatenverarbeitung und Elektronik, Postfach 3640, 76021 Karlsruhe (Germany); Fraenkle, F.; Habermehl, F.; Renschler, P. [Universitaet Karlsruhe - TH, Institut fuer Experimentelle Kernphysik, Postfach 6980, 76128 Karlsruhe (Germany); Steidl, M [Forschungszentrum Karlsruhe, Institut fuer Kernphysik, Postfach 3640, 76021 Karlsruhe (Germany)

    2010-12-11

    The KATRIN neutrino mass experiment is based on a precise energy measurement ({Delta}E/E=5x10{sup -5}) of electrons emerging from tritium beta decay (E{sub max}=18.6 keV). This is done by a large electrostatic retarding spectrometer (MAC-E Filter), which is followed by an electron detector. Key requirements for this detector are a large sensitive area ({approx}80 cm{sup 2}), a certain energy resolution ({Delta}E=600 eV - 18.6 keV) but also a certain spatial resolution ({approx}3 mm), which leads to a multi-pixel design. As a tentative design on the way to the final detector, but also for operational service on the so-called pre-spectrometer experiment, a detector system with a reduced size (16 cm{sup 2}) and a reduced pixel number (64), making use of a monolithic segmented silicon PIN diode, was designed and built. While the design and very first measurements have been presented in Wuestling et al. , this publication shows the operational performance of the detector system. The robust concept of the electronics allowed adaptation to mechanically different experimental setups. The spacial resolution of the detector system proved to be essential in examining Penning trap induced background and other effects in the pre-spectrometer experiment. The detector performance test runs include energy resolution and calibration, background rates, correlation between pixels (crosstalk), spatially resolved rate analysis, and a dead-layer measurement . The detector allows for background searches with a sensitivity as low as 1.3x10{sup -3} cps/cm{sup 2} in the energy range of 20 keV. This allows the pre-spectrometer to be characterized with e-gun illumination with a signal to background ratio of better than 10{sup 5} and the search for ultra low Penning discharge emissions.

  15. Results from a 64-pixel PIN-diode detector system for low-energy beta-electrons

    Science.gov (United States)

    Wuestling, Sascha; Fraenkle, F.; Habermehl, F.; Renschler, P.; Steidl, M.

    2010-12-01

    The KATRIN neutrino mass experiment is based on a precise energy measurement (Δ E/ E=5×10 -5) of electrons emerging from tritium beta decay ( Emax=18.6 keV). This is done by a large electrostatic retarding spectrometer (MAC-E Filter), which is followed by an electron detector. Key requirements for this detector are a large sensitive area (˜80 cm 2), a certain energy resolution (Δ E=600 eV @ 18.6 keV) but also a certain spatial resolution (˜3 mm), which leads to a multi-pixel design. As a tentative design on the way to the final detector, but also for operational service on the so-called pre-spectrometer experiment, a detector system with a reduced size (16 cm 2) and a reduced pixel number (64), making use of a monolithic segmented silicon PIN diode, was designed and built. While the design and very first measurements have been presented in Wuestling et al. [6], this publication shows the operational performance of the detector system. The robust concept of the electronics allowed adaptation to mechanically different experimental setups. The spacial resolution of the detector system proved to be essential in examining Penning trap induced background and other effects in the pre-spectrometer experiment. The detector performance test runs include energy resolution and calibration, background rates, correlation between pixels (crosstalk), spatially resolved rate analysis, and a dead-layer measurement [7]. The detector allows for background searches with a sensitivity as low as 1.3×10 -3 cps/cm 2 in the energy range of 20 keV. This allows the pre-spectrometer to be characterized with e-gun illumination with a signal to background ratio of better than 10 5 and the search for ultra low Penning discharge emissions.

  16. An FPGA-based heterogeneous image fusion system design method

    Science.gov (United States)

    Song, Le; Lin, Yu-chi; Chen, Yan-hua; Zhao, Mei-rong

    2011-08-01

    Taking the advantages of FPGA's low cost and compact structure, an FPGA-based heterogeneous image fusion platform is established in this study. Altera's Cyclone IV series FPGA is adopted as the core processor of the platform, and the visible light CCD camera and infrared thermal imager are used as the image-capturing device in order to obtain dualchannel heterogeneous video images. Tailor-made image fusion algorithms such as gray-scale weighted averaging, maximum selection and minimum selection methods are analyzed and compared. VHDL language and the synchronous design method are utilized to perform a reliable RTL-level description. Altera's Quartus II 9.0 software is applied to simulate and implement the algorithm modules. The contrast experiments of various fusion algorithms show that, preferably image quality of the heterogeneous image fusion can be obtained on top of the proposed system. The applied range of the different fusion algorithms is also discussed.

  17. [{sup 18}F]Flutemetamol amyloid-beta PET imaging compared with [{sup 11}C]PIB across the spectrum of Alzheimer's disease

    Energy Technology Data Exchange (ETDEWEB)

    Hatashita, Shizuo; Yamasaki, Hidetomo [Shonan-Atsugi Hospital, Neurology, PET Center, Atsugi (Japan); Suzuki, Yutaka; Wakebe, Daichi; Hayakawa, Hideki [Shonan-Atsugi Hospital, Radiology, PET Center, Atsugi (Japan); Tanaka, Kumiko [Shonan-Atsugi Hospital, Pharmacology, PET Center, Atsugi (Japan)

    2014-02-15

    The aim was to identify the amyloid beta (Aβ) deposition by positron emission tomography (PET) imaging with the {sup 18}F-labeled Pittsburgh compound B (PIB) derivative [{sup 18}F]flutemetamol (FMM) across a spectrum of Alzheimer's disease (AD) and to compare Aβ deposition between [{sup 18}F]FMM and [{sup 11}C]PIB PET imaging. The study included 36 patients with AD, 68 subjects with mild cognitive impairment (MCI), 41 older healthy controls (HC) (aged ≥56), 11 young HC (aged ≤45), and 10 transitional HC (aged 46-55). All 166 subjects underwent 30-min static [{sup 18}F]FMM PET 85 min after injection, 60-min dynamic [{sup 11}C]PIB PET, and cognitive testing. [{sup 18}F]FMM scans were assessed visually, and standardized uptake value ratios (SUVR) were defined quantitatively in regions of interest identified on coregistered MRI (cerebellar cortex as a reference region). The PIB distribution volume ratios (DVR) were determined in the same regions. Of 36 AD patients, 35 had positive scans, while 36 of 41 older HC subjects had negative scans. [{sup 18}F]FMM scans had a sensitivity of 97.2 % and specificity of 85.3 % in distinguishing AD patients from older HC subjects, and a specificity of 100 % for young and transitional HC subjects. The [{sup 11}C]PIB scan had the same results. Interreader agreement was excellent (kappa score = 0.81). The cortical FMM SUVR in AD patients was significantly greater than in older HC subjects (1.76 ± 0.23 vs 1.30 ± 0.26, p < 0.01). Of the MCI patients, 68 had a bimodal distribution of SUVR, and 29 of them (42.6 %) had positive scans. Cortical FMM SUVR values were strongly correlated with PIB DVR (r = 0.94, n = 145, p < 0.001). [{sup 18}F]FMM PET imaging detects Aβ deposition in patients along the continuum from normal cognitive status to dementia of AD and discriminates AD patients from HC subjects, similar to [{sup 11}C]PIB PET. (orig.)

  18. Oxidation state variation under {beta}-irradiation in an iron-bearing soda lime glass system

    Energy Technology Data Exchange (ETDEWEB)

    Rossano, S; Boizot, B [Lab. des Solides Irradies, UMR 7642 CEA-CNRS-Ecole Polytechnique, Palaiseau (France); Jean-Soro, L; Hullebusch, E van; Gouzin, L; Combes, R [Lab. Geomateriaux et Environnement, EA 4119, Univ. Paris-Est Marne la Vallee (France); Farges, F [Museum National d' Histoire Naturelle de Paris, UMR CNRS 7202, Paris (France); Labanowski, J [Lab. de Chimie et Microbiologie de l' Eau, UMR CNRS 6008, Univ. de Poitiers (France); Linares, J [GEMAC, UMR 8635, Univ. de Versailles Saint-Quentin-en-Yvelines (France); Swarbrick, J C [European Synchrotron Radiation Facility (ESRF), 38043 Grenoble, Cedex 9 (France); Harfouche, M, E-mail: stephanie.rossano@univ-paris-est.f [Paul Scherrer Institut, Swiss Light Source, 5232 Villigen (Switzerland)

    2009-11-15

    The effect of ionizing radiation on glasses in the system SiO{sub 2}-CaO-Na{sub 2}O-Fe{sub 2}O{sub 3} is investigated as a function of iron concentration or / and irradiation dose by a pre-edge analysis at the iron K-edge. While reduction phenomenon is clearly observed for large irradiation doses (5 C), the effect of irradiation for intermediate doses is more challenging to interpret. Comparison between X-ray absorption measurements, colorimetry results and Electron Paramagnetic Resonance measurements suggest that iron environment may be modified without the ions being reduced.

  19. Development of CCD Imaging System Using Thermoelectric Cooling Method

    Directory of Open Access Journals (Sweden)

    Youngsik Park

    2000-06-01

    Full Text Available We developed low light CCD imaging system using thermoelectric cooling method collaboration with a company to design a commercial model. It consists of Kodak KAF-0401E (768x512 pixels CCD chip,thermoelectric module manufactured by Thermotek. This TEC system can reach an operative temperature of -25deg. We employed an Uniblitz VS25S shutter and it has capability a minimum exposure time 80ms. The system components are an interface card using a Korea Astronomy Observatory (hereafter KAO ISA bus controller, image acquisition with AD9816 chip, that is 12bit video processor. The performance test with this imaging system showed good operation within the initial specification of our design. It shows a dark current less than 0.4e-/pixel/sec at a temperature of -10deg, a linearity 99.9+/-0.1%, gain 4.24e-adu, and system noise is 25.3e- (rms. For low temperature CCD operation, we designed a TEC, which uses a one-stage peltier module and forced air heat exchanger. This TEC imaging system enables accurate photometry (+/-0.01mag even though the CCD is not at 'conventional' cryogenic temperatures (140K. The system can be a useful instrument for any other imaging applications. Finally, with this system, we obtained several images of astronomical objects for system performance tests.

  20. Ignition of deuterium based fuel cycles in a high beta system

    International Nuclear Information System (INIS)

    Hirano, K.

    1987-01-01

    A steady state self-consistent plasma modeling applied to a system having close to unity, such as FRC or like, is found to be quite effective in solving the problems independently of any anomalous process and proves the existence of ignited state of deuterium based fuel cycles. The temperature ranges that the plasma falls into ignited state are obtained as a function of relative feeding rates of tritium and 3 He to deuterium's. We find pure DD cycle will not ignite so that 3 He or/and tritium must be added as catalyzer to achieve ignition. Standing on the points to construct a cleaner system yielding smaller amount of 14 MeV neutrons and to burn the fuel in steady state for long periods of time, we have confirmed superiority of the complex composed of the master reactor of 3 He-Cat.D cycle (catalyzed DD cycle reinjecting only fusion produced 3 He) and the satellite reactor of 3 He enriched D 3 He cycle. In case storage of tritium for 3 He by β - decay is turned out not to be allowed environmentally, we may utilize conventional catalyzed DD cycle although 14 MeV neutron yields will be increased by 35 % over the complex. It is demonstrated that advanced fuel cycle reactors can be very simple in constructions and compact in size such that the field strength and the plasma volume of the order of JT-60's may be enough for 1000 MW power plant. (author)

  1. Design and implementation of typical target image database system

    International Nuclear Information System (INIS)

    Qin Kai; Zhao Yingjun

    2010-01-01

    It is necessary to provide essential background data and thematic data timely in image processing and application. In fact, application is an integrating and analyzing procedure with different kinds of data. In this paper, the authors describe an image database system which classifies, stores, manages and analyzes database of different types, such as image database, vector database, spatial database, spatial target characteristics database, its design and structure. (authors)

  2. An image analysis system for near-infrared (NIR) fluorescence lymph imaging

    Science.gov (United States)

    Zhang, Jingdan; Zhou, Shaohua Kevin; Xiang, Xiaoyan; Rasmussen, John C.; Sevick-Muraca, Eva M.

    2011-03-01

    Quantitative analysis of lymphatic function is crucial for understanding the lymphatic system and diagnosing the associated diseases. Recently, a near-infrared (NIR) fluorescence imaging system is developed for real-time imaging lymphatic propulsion by intradermal injection of microdose of a NIR fluorophore distal to the lymphatics of interest. However, the previous analysis software3, 4 is underdeveloped, requiring extensive time and effort to analyze a NIR image sequence. In this paper, we develop a number of image processing techniques to automate the data analysis workflow, including an object tracking algorithm to stabilize the subject and remove the motion artifacts, an image representation named flow map to characterize lymphatic flow more reliably, and an automatic algorithm to compute lymph velocity and frequency of propulsion. By integrating all these techniques to a system, the analysis workflow significantly reduces the amount of required user interaction and improves the reliability of the measurement.

  3. Image registration for a UV-Visible dual-band imaging system

    Science.gov (United States)

    Chen, Tao; Yuan, Shuang; Li, Jianping; Xing, Sheng; Zhang, Honglong; Dong, Yuming; Chen, Liangpei; Liu, Peng; Jiao, Guohua

    2018-06-01

    The detection of corona discharge is an effective way for early fault diagnosis of power equipment. UV-Visible dual-band imaging can detect and locate corona discharge spot at all-weather condition. In this study, we introduce an image registration protocol for this dual-band imaging system. The protocol consists of UV image denoising and affine transformation model establishment. We report the algorithm details of UV image preprocessing, affine transformation model establishment and relevant experiments for verification of their feasibility. The denoising algorithm was based on a correlation operation between raw UV images, a continuous mask and the transformation model was established by using corner feature and a statistical method. Finally, an image fusion test was carried out to verify the accuracy of affine transformation model. It has proved the average position displacement error between corona discharge and equipment fault at different distances in a 2.5m-20 m range are 1.34 mm and 1.92 mm in the horizontal and vertical directions, respectively, which are precise enough for most industrial applications. The resultant protocol is not only expected to improve the efficiency and accuracy of such imaging system for locating corona discharge spot, but also supposed to provide a more generalized reference for the calibration of various dual-band imaging systems in practice.

  4. Practical evaluation of clinical image quality (4). Determination of image quality in digital radiography system

    International Nuclear Information System (INIS)

    Katayama, Reiji

    2016-01-01

    Recently, for medical imaging, digital radiography systems are widely used in clinical practices. However, a study in the past reported that a patient radiation exposure level by digital radiography is in fact not lower than that by analog radiography system. High level of attention needs to be paid for over-exposure when using the conventional analog radiography with a screen and a film, as it results in high density of the film. However, for digital radiography systems, since the automatic adjusting function of image density is equipped with them, no attention for radiation dose need to be paid. Thus technologists tend to be careless and results in higher chance for over-exposure. Current digital radiography systems are high-performance in the image properties and capable of patient dose reduction. Especially, the image quality of the flat panel detector system is recognized, higher than that of the computed radiography system by imaging plates, in both objective and subjective evaluations. Therefore, we technologists are responsible for optimizing the balance between the image quality of the digital radiogram and the radiation dose required for each case. Moreover, it is also required for us as medical technologists to make effective use of such evaluation result of medical images for patients. (author)

  5. Imputing Variants in HLA-DR Beta Genes Reveals That HLA-DRB1 Is Solely Associated with Rheumatoid Arthritis and Systemic Lupus Erythematosus.

    Directory of Open Access Journals (Sweden)

    Kwangwoo Kim

    Full Text Available The genetic association of HLA-DRB1 with rheumatoid arthritis (RA and systemic lupus erythematosus (SLE is well documented, but association with other HLA-DR beta genes (HLA-DRB3, HLA-DRB4 and HLA-DRB5 has not been thoroughly studied, despite their similar functions and chromosomal positions. We examined variants in all functional HLA-DR beta genes in RA and SLE patients and controls, down to the amino-acid level, to better understand disease association with the HLA-DR locus. To this end, we improved an existing HLA reference panel to impute variants in all protein-coding HLA-DR beta genes. Using the reference panel, HLA variants were inferred from high-density SNP data of 9,271 RA-control subjects and 5,342 SLE-control subjects. Disease association tests were performed by logistic regression and log-likelihood ratio tests. After imputation using the newly constructed HLA reference panel and statistical analysis, we observed that HLA-DRB1 variants better accounted for the association between MHC and susceptibility to RA and SLE than did the other three HLA-DRB variants. Moreover, there were no secondary effects in HLA-DRB3, HLA-DRB4, or HLA-DRB5 in RA or SLE. Of all the HLA-DR beta chain paralogs, those encoded by HLA-DRB1 solely or dominantly influence susceptibility to RA and SLE.

  6. A luminescence imaging system based on a CCD camera

    DEFF Research Database (Denmark)

    Duller, G.A.T.; Bøtter-Jensen, L.; Markey, B.G.

    1997-01-01

    Stimulated luminescence arising from naturally occurring minerals is likely to be spatially heterogeneous. Standard luminescence detection systems are unable to resolve this variability. Several research groups have attempted to use imaging photon detectors, or image intensifiers linked...... to photographic systems, in order to obtain spatially resolved data. However, the former option is extremely expensive and it is difficult to obtain quantitative data from the latter. This paper describes the use of a CCD camera for imaging both thermoluminescence and optically stimulated luminescence. The system...

  7. OBJECT-SPACE MULTI-IMAGE MATCHING OF MOBILE-MAPPING-SYSTEM IMAGE SEQUENCES

    Directory of Open Access Journals (Sweden)

    Y. C. Chen

    2012-07-01

    Full Text Available This paper proposes an object-space multi-image matching procedure of terrestrial MMS (Mobile Mapping System image sequences to determine the coordinates of an object point automatically and reliably. This image matching procedure can be applied to find conjugate points of MMS image sequences efficiently. Conventional area-based image matching methods are not reliable to deliver accurate matching results for this application due to image scale variations, viewing angle variations, and object occlusions. In order to deal with these three matching problems, an object space multi-image matching is proposed. A modified NCC (Normalized Cross Correlation coefficient is proposed to measure the similarity of image patches. A modified multi-window matching procedure will also be introduced to solve the problem of object occlusion. A coarse-to-fine procedure with a combination of object-space multi-image matching and multi-window matching is adopted. The proposed procedure has been implemented for the purpose of matching terrestrial MMS image sequences. The ratio of correct matches of this experiment was about 80 %. By providing an approximate conjugate point in an overlapping image manually, most of the incorrect matches could be fixed properly and the ratio of correct matches was improved up to 98 %.

  8. A novel track imaging system as a range counter

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Z. [National Institute of Radiological Sciences (Japan); Matsufuji, N. [National Institute of Radiological Sciences (Japan); Tokyo Institute of Technology (Japan); Kanayama, S. [Chiba University (Japan); Ishida, A. [National Institute of Radiological Sciences (Japan); Tokyo Institute of Technology (Japan); Kohno, T. [Tokyo Institute of Technology (Japan); Koba, Y.; Sekiguchi, M.; Kitagawa, A.; Murakami, T. [National Institute of Radiological Sciences (Japan)

    2016-05-01

    An image-intensified, camera-based track imaging system has been developed to measure the tracks of ions in a scintillator block. To study the performance of the detector unit in the system, two types of scintillators, a dosimetrically tissue-equivalent plastic scintillator EJ-240 and a CsI(Tl) scintillator, were separately irradiated with carbon ion ({sup 12}C) beams of therapeutic energy from HIMAC at NIRS. The images of individual ion tracks in the scintillators were acquired by the newly developed track imaging system. The ranges reconstructed from the images are reported here. The range resolution of the measurements is 1.8 mm for 290 MeV/u carbon ions, which is considered a significant improvement on the energy resolution of the conventional ΔE/E method. The detector is compact and easy to handle, and it can fit inside treatment rooms for in-situ studies, as well as satisfy clinical quality assurance purposes.

  9. System for objective assessment of image differences in digital cinema

    Science.gov (United States)

    Fliegel, Karel; Krasula, Lukáš; Páta, Petr; Myslík, Jiří; Pecák, Josef; Jícha, Marek

    2014-09-01

    There is high demand for quick digitization and subsequent image restoration of archived film records. Digitization is very urgent in many cases because various invaluable pieces of cultural heritage are stored on aging media. Only selected records can be reconstructed perfectly using painstaking manual or semi-automatic procedures. This paper aims to answer the question what are the quality requirements on the restoration process in order to obtain acceptably close visual perception of the digitally restored film in comparison to the original analog film copy. This knowledge is very important to preserve the original artistic intention of the movie producers. Subjective experiment with artificially distorted images has been conducted in order to answer the question what is the visual impact of common image distortions in digital cinema. Typical color and contrast distortions were introduced and test images were presented to viewers using digital projector. Based on the outcome of this subjective evaluation a system for objective assessment of image distortions has been developed and its performance tested. The system utilizes calibrated digital single-lens reflex camera and subsequent analysis of suitable features of images captured from the projection screen. The evaluation of captured image data has been optimized in order to obtain predicted differences between the reference and distorted images while achieving high correlation with the results of subjective assessment. The system can be used to objectively determine the difference between analog film and digital cinema images on the projection screen.

  10. Computer simulation of radiographic images sharpness in several system of image record

    International Nuclear Information System (INIS)

    Silva, Marcia Aparecida; Schiable, Homero; Frere, Annie France; Marques, Paulo M.A.; Oliveira, Henrique J.Q. de; Alves, Fatima F.R.; Medeiros, Regina B.

    1996-01-01

    A method to predict the influence of the record system on radiographic images sharpness by computer simulation is studied. The method intend to previously show the image to be obtained for each type of film or screen-film combination used during the exposure

  11. Pattern recognition and expert image analysis systems in biomedical image processing (Invited Paper)

    Science.gov (United States)

    Oosterlinck, A.; Suetens, P.; Wu, Q.; Baird, M.; F. M., C.

    1987-09-01

    This paper gives an overview of pattern recoanition techniques (P.R.) used in biomedical image processing and problems related to the different P.R. solutions. Also the use of knowledge based systems to overcome P.R. difficulties, is described. This is illustrated by a common example ofabiomedical image processing application.

  12. Breast imaging with the SoftVue imaging system: first results

    Science.gov (United States)

    Duric, Neb; Littrup, Peter; Schmidt, Steven; Li, Cuiping; Roy, Olivier; Bey-Knight, Lisa; Janer, Roman; Kunz, Dave; Chen, Xiaoyang; Goll, Jeffrey; Wallen, Andrea; Zafar, Fouzaan; Allada, Veerendra; West, Erik; Jovanovic, Ivana; Li, Kuo; Greenway, William

    2013-03-01

    For women with dense breast tissue, who are at much higher risk for developing breast cancer, the performance of mammography is at its worst. Consequently, many early cancers go undetected when they are the most treatable. Improved cancer detection for women with dense breasts would decrease the proportion of breast cancers diagnosed at later stages, which would significantly lower the mortality rate. The emergence of whole breast ultrasound provides good performance for women with dense breast tissue, and may eliminate the current trade-off between the cost effectiveness of mammography and the imaging performance of more expensive systems such as magnetic resonance imaging. We report on the performance of SoftVue, a whole breast ultrasound imaging system, based on the principles of ultrasound tomography. SoftVue was developed by Delphinus Medical Technologies and builds on an early prototype developed at the Karmanos Cancer Institute. We present results from preliminary testing of the SoftVue system, performed both in the lab and in the clinic. These tests aimed to validate the expected improvements in image performance. Initial qualitative analyses showed major improvements in image quality, thereby validating the new imaging system design. Specifically, SoftVue's imaging performance was consistent across all breast density categories and had much better resolution and contrast. The implications of these results for clinical breast imaging are discussed and future work is described.

  13. Developments of optical fast-gated imaging systems

    International Nuclear Information System (INIS)

    Koehler, H.A.; Kotecki, D.

    1984-08-01

    Several fast-gated imaging systems to measure ultra-fast single-transient data have been developed for time-resolved imaging of pulsed radiation sources. These systems were designed to achieve image recording times of 1 to 3 ms and dynamic ranges of >200:1 to produce large two-dimensional images (greater than or equal to 10 4 spatial points) of 1 to 2 ns exposure and small two-dimensional images (less than or equal to 200 spatial points) of less than or equal to 0.5 ns exposure. Both MCP intensified solid-state two-dimensional framing cameras and streak camera/solid-state camera systems were used; the framing camera system provides snap shots with high spatial resolution whereas the streak camera system provides for limited spatial points each with high temporal resolution. Applications of these systems include electron-beam, x-ray, gamma-ray, and neutron diagnostics. This report reviews the characteristics of the major components of fast-gated imaging systems developed at Lawrence Livermore National Laboratory. System performances are described in view of major experiments, and the diagnostic requirements of new experiments in atomic physics (x-ray lasers) and nuclear physics (fusion) are indicated

  14. Evaluating Picture Quality of Image Plates in Digital CR Systems

    Energy Technology Data Exchange (ETDEWEB)

    Kwak, Byung Joon [Dept. of Radiological Tecnology, Choonhae College of Health Science, Ulsan (Korea, Republic of); Ji Tae Jeong [Dept. of Radiological Science, Kaya University, Kimhae (Korea, Republic of)

    2011-12-15

    Lab effectively supplemented the effects of outside radiation on image plates in the process of image acquisition of CR (computed radiography) systems and conducted for effective utilization in the case of clinical application. For this, Lab classified the storage places and time periods of image plates and compared and analyzed the differences between small dark spots. Lab also assessed the concentration distribution within the boundaries of images. Lab compared and measured the number of dark spots in a light room and a dark room depending on the storage places of image plates and found that dark spots slightly increased in an image plate when stored in a light room on the first and second days. Dark spots increased in proportion to the length of time stored. In the case of the image plate stored in a dark room, the number of dark spots remarkably decreased. With regard to picture quality as related to the location of image plates, the damage to picture quality could be reduced by locating regions of interest in the center. With regard to differences in sharpness following changes in the thickness of subjects, fewer scatter rays occurred and sharpness improved by reducing the thickness of subjects as much as possible. To get medical images of excellent quality, image plates should be managed effectively and it is desirable to keep images plates in dark iron plate boxes and not to expose them to outside radiation for a long time.

  15. Evaluating Picture Quality of Image Plates in Digital CR Systems

    International Nuclear Information System (INIS)

    Kwak, Byung Joon; Ji Tae Jeong

    2011-01-01

    Lab effectively supplemented the effects of outside radiation on image plates in the process of image acquisition of CR (computed radiography) systems and conducted for effective utilization in the case of clinical application. For this, Lab classified the storage places and time periods of image plates and compared and analyzed the differences between small dark spots. Lab also assessed the concentration distribution within the boundaries of images. Lab compared and measured the number of dark spots in a light room and a dark room depending on the storage places of image plates and found that dark spots slightly increased in an image plate when stored in a light room on the first and second days. Dark spots increased in proportion to the length of time stored. In the case of the image plate stored in a dark room, the number of dark spots remarkably decreased. With regard to picture quality as related to the location of image plates, the damage to picture quality could be reduced by locating regions of interest in the center. With regard to differences in sharpness following changes in the thickness of subjects, fewer scatter rays occurred and sharpness improved by reducing the thickness of subjects as much as possible. To get medical images of excellent quality, image plates should be managed effectively and it is desirable to keep images plates in dark iron plate boxes and not to expose them to outside radiation for a long time.

  16. Parameter Optimization of Multi-Element Synthetic Aperture Imaging Systems

    Directory of Open Access Journals (Sweden)

    Vera Behar

    2007-03-01

    Full Text Available In conventional ultrasound imaging systems with phased arrays, the further improvement of lateral resolution requires enlarging of the number of array elements that in turn increases both, the complexity and the cost, of imaging systems. Multi-element synthetic aperture focusing (MSAF systems are a very good alternative to conventional systems with phased arrays. The benefit of the synthetic aperture is in reduction of the system complexity, cost and acquisition time. In a MSAF system considered in the paper, a group of elements transmit and receive signals simultaneously, and the transmit beam is defocused to emulate a single element response. The echo received at each element of a receive sub-aperture is recorded in the computer memory. The process of transmission/reception is repeated for all positions of a transmit sub-aperture. All the data recordings associated with each corresponding pair "transmit-receive sub-aperture" are then focused synthetically producing a low-resolution image. The final high-resolution image is formed by summing of the all low-resolution images associated with transmit/receive sub-apertures. A problem of parameter optimization of a MSAF system is considered in this paper. The quality of imaging (lateral resolution and contrast is expressed in terms of the beam characteristics - beam width and side lobe level. The comparison between the MSAF system described in the paper and an equivalent conventional phased array system shows that the MSAF system acquires images of equivalent quality much faster using only a small part of the power per image.

  17. Image processing. A system for the automatic sorting of chromosomes

    International Nuclear Information System (INIS)

    Najai, Amor

    1977-01-01

    The present paper deals with two aspects of the system: - an automata (specialized hardware) dedicated to image processing. Images are digitized, divided into sub-units and computations are carried out on their main parameters. - A software for the automatic recognition and sorting of chromosomes is implemented on a Multi-20 minicomputer, connected to the automata. (author) [fr

  18. Design and applications of Computed Industrial Tomographic Imaging System (CITIS)

    Energy Technology Data Exchange (ETDEWEB)

    Ramakrishna, G S; Kumar, Umesh; Datta, S S [Bhabha Atomic Research Centre, Bombay (India). Isotope Div.

    1994-12-31

    This paper highlights the design and development of a prototype Computed Tomographic (CT) imaging system and its software for image reconstruction, simulation and display. It also describes results obtained with several test specimens including Dhruva reactor uranium fuel assembly and possibility of using neutrons as well as high energy x-rays in computed tomography. 5 refs., 4 figs.

  19. Integrating two spectral imaging systems in an automated mineralogy application

    CSIR Research Space (South Africa)

    Harris, D

    2009-11-01

    Full Text Available is treated in batches, with trays of mono-layered material presented to various imaging systems. The identification of target grains is achieved by means of spectral imaging in two wavelength bands (Visible, and Long Wave Infrared). Target grains...

  20. Robust algebraic image enhancement for intelligent control systems

    Science.gov (United States)

    Lerner, Bao-Ting; Morrelli, Michael

    1993-01-01

    Robust vision capability for intelligent control systems has been an elusive goal in image processing. The computationally intensive techniques a necessary for conventional image processing make real-time applications, such as object tracking and collision avoidance difficult. In order to endow an intelligent control system with the needed vision robustness, an adequate image enhancement subsystem capable of compensating for the wide variety of real-world degradations, must exist between the image capturing and the object recognition subsystems. This enhancement stage must be adaptive and must operate with consistency in the presence of both statistical and shape-based noise. To deal with this problem, we have developed an innovative algebraic approach which provides a sound mathematical framework for image representation and manipulation. Our image model provides a natural platform from which to pursue dynamic scene analysis, and its incorporation into a vision system would serve as the front-end to an intelligent control system. We have developed a unique polynomial representation of gray level imagery and applied this representation to develop polynomial operators on complex gray level scenes. This approach is highly advantageous since polynomials can be manipulated very easily, and are readily understood, thus providing a very convenient environment for image processing. Our model presents a highly structured and compact algebraic representation of grey-level images which can be viewed as fuzzy sets.

  1. Nuclear magnetic resonance imaging of the central nervous system

    International Nuclear Information System (INIS)

    Knaap, M.S. van der; Valk, J.

    1989-01-01

    In this article a review is given of the use of magnetic resonance imaging for the central nervous system. An example of the screening of the population for multiple scelerosis is given. A good preliminary examination and the supply of relevant information to the person which performs the imaging is necessary. (R.B.). 9 figs.; 4 tabs

  2. Laboratory Characterization of an Imaging Reflectometer System

    International Nuclear Information System (INIS)

    Munsat, T.; Mazzucato, E.; Park, H.; Domier, C.W.; Luhmann, N.C. Jr.; Donne, A.J.H.; Pol, M. van de

    2003-01-01

    While microwave reflectometry has proven to be a sensitive tool for measuring electron density fluctuations in many circumstances, it has also been shown to have limited viability for core measurements and/or conditions of strong turbulence. To this end, a new instrument based on 2-D imaging reflectometry has been developed to measure density fluctuations over an extended plasma region in the TEXTOR tokamak. Laboratory characterization of this instrument has been performed using corrugated reflecting targets as an approximation to plasma reflections including 2-D turbulent fluctuations of various magnitude and poloidal wavenumber. Within this approximation, the imaging reflectometer can recover the spectral and spatial characteristics of the reflection layer lost to or otherwise inaccessible to conventional techniques

  3. BETA (Bitter Electromagnet Testing Apparatus)

    Science.gov (United States)

    Bates, Evan M.; Birmingham, William J.; Rivera, William F.; Romero-Talamas, Carlos A.

    2017-10-01

    The Bitter Electromagnet Testing Apparatus (BETA) is a 1-Tesla (T) prototype of the 10-T Adjustable Long Pulse High-Field Apparatus (ALPHA). These water-cooled resistive magnets use high DC currents to produce strong uniform magnetic fields. Presented here is the successful completion of the BETA project and experimental results validating analytical magnet designing methods developed at the Dusty Plasma Laboratory (DPL). BETA's final design specifications will be highlighted which include electromagnetic, thermal and stress analyses. The magnet core design will be explained which include: Bitter Arcs, helix starters, and clamping annuli. The final version of the magnet's vessel and cooling system are also presented, as well as the electrical system of BETA, which is composed of a unique solid-state breaker circuit. Experimental results presented will show the operation of BETA at 1 T. The results are compared to both analytical design methods and finite element analysis calculations. We also explore the steady state maximums and theoretical limits of BETA's design. The completion of BETA validates the design and manufacturing techniques that will be used in the succeeding magnet, ALPHA.

  4. An imaging system for a gamma camera

    International Nuclear Information System (INIS)

    Miller, D.W.; Gerber, M.S.

    1980-01-01

    A detailed description is given of a novel gamma camera which is designed to produce superior images than conventional cameras used in nuclear medicine. The detector consists of a solid state detector (e.g. germanium) which is formed to have a plurality of discrete components to enable 2-dimensional position identification. Details of the electronic processing circuits are given and the problems and limitations introduced by noise are discussed in full. (U.K.)

  5. Spectrally Adaptable Compressive Sensing Imaging System

    Science.gov (United States)

    2014-05-01

    capture the hyperspectral scene. Several simulations and experimental measurements demonstrate the benefits of the new discretization model. 11...apertures are used sequentially to capture the hyperspectral scene. Several simulations and experimental measurements demonstrate the benefits of the new...with our DMD-SSI setup. Figure 5.22(a) shows the imaging target used in this experiment, which is a red chili pepper with a green stem. Figure 5.22(b

  6. Nuclear imaging of the skeletal system

    International Nuclear Information System (INIS)

    Yong Whee Bahk

    1992-01-01

    Bone scintigraphy is one of the most valuable nuclear imaging procedure, especially remarkable for its high sensitivity in disclosing bone metastasis of cancer long before radiographic demonstration. Bone scintigraphy is also useful in the diagnosis of covert fracture, occult trauma, bone contusion, early acute osteomyelitis, acute pyogenic arthritis and avascular bone necrosis. Measurements of bone clearance of radiopharmaceuticals, absorptiometry and quantitative bone scintigraphy are applied to the study of metabolic bone disorders such as osteoporosis and osteomalacia

  7. Nuclear imaging of the skeletal system

    Energy Technology Data Exchange (ETDEWEB)

    Bahk, Yong Whee

    1993-12-31

    Bone scintigraphy is one of the most valuable nuclear imaging procedure, especially remarkable for its high sensitivity in disclosing bone metastasis of cancer long before radiographic demonstration. Bone scintigraphy is also useful in the diagnosis of covert fracture, occult trauma, bone contusion, early acute osteomyelitis, acute pyogenic arthritis and avascular bone necrosis. Measurements of bone clearance of radiopharmaceuticals, absorptiometry and quantitative bone scintigraphy are applied to the study of metabolic bone disorders such as osteoporosis and osteomalacia

  8. Fast imaging system on Tore Supra

    International Nuclear Information System (INIS)

    Geraud, A.; Salasca, S.; Verger, J. M.; Alarcon, T.; Agarici, G.; Bremond, S.; Chenevois, J. P.; Geynet, M.; Migozzi, J. B.; Reux, C.

    2009-01-01

    A new endoscope aiming at transferring the image of a poloidal section of the Tore Supra plasma to a fast camera able to record frames at a speed up to 4800 frames per second at full resolution, or much faster for a limited number of pixel, has been installed on Tore Supra. First movies showing the light emission associated to fast phenomena such as plasma start up, disruptions or gas and pellet injections have been produced.

  9. Establishing Information Security Systems via Optical Imaging

    Science.gov (United States)

    2015-08-11

    SLM, spatial light modulator; BSC, non - polarizing beam splitter cube; CCD, charge-coupled device. In computational ghost imaging, a series of...Laser Object Computer Fig. 5. A schematic setup for the proposed method using holography: BSC, Beam splitter cube; CCD, Charge-coupled device. The...interference between reference and object beams . (a) (e) (d) (c) (b) Distribution Code A: Approved for public release, distribution is unlimited

  10. An adaptive optics imaging system designed for clinical use

    Science.gov (United States)

    Zhang, Jie; Yang, Qiang; Saito, Kenichi; Nozato, Koji; Williams, David R.; Rossi, Ethan A.

    2015-01-01

    Here we demonstrate a new imaging system that addresses several major problems limiting the clinical utility of conventional adaptive optics scanning light ophthalmoscopy (AOSLO), including its small field of view (FOV), reliance on patient fixation for targeting imaging, and substantial post-processing time. We previously showed an efficient image based eye tracking method for real-time optical stabilization and image registration in AOSLO. However, in patients with poor fixation, eye motion causes the FOV to drift substantially, causing this approach to fail. We solve that problem here by tracking eye motion at multiple spatial scales simultaneously by optically and electronically integrating a wide FOV SLO (WFSLO) with an AOSLO. This multi-scale approach, implemented with fast tip/tilt mirrors, has a large stabilization range of ± 5.6°. Our method consists of three stages implemented in parallel: 1) coarse optical stabilization driven by a WFSLO image, 2) fine optical stabilization driven by an AOSLO image, and 3) sub-pixel digital registration of the AOSLO image. We evaluated system performance in normal eyes and diseased eyes with poor fixation. Residual image motion with incremental compensation after each stage was: 1) ~2–3 arc minutes, (arcmin) 2) ~0.5–0.8 arcmin and, 3) ~0.05–0.07 arcmin, for normal eyes. Performance in eyes with poor fixation was: 1) ~3–5 arcmin, 2) ~0.7–1.1 arcmin and 3) ~0.07–0.14 arcmin. We demonstrate that this system is capable of reducing image motion by a factor of ~400, on average. This new optical design provides additional benefits for clinical imaging, including a steering subsystem for AOSLO that can be guided by the WFSLO to target specific regions of interest such as retinal pathology and real-time averaging of registered images to eliminate image post-processing. PMID:26114033

  11. System for digitalization of medical images based on DICOM standard

    Directory of Open Access Journals (Sweden)

    Čabarkapa Slobodan

    2009-01-01

    Full Text Available According to DICOM standard, which defines both medical image information and user information, a new system for digitalizing medical images is involved as a part of the main system for archiving and retrieving medical databases. The basic characteristics of this system are described in this paper. Furthermore, the analysis of some important DICOM header's tags which are used in this system, are presented, too. Having chosen the appropriate tags in order to preserve important information, the efficient system has been created. .

  12. ATR/OTR-SY Tank Camera Purge System and in Tank Color Video Imaging System

    International Nuclear Information System (INIS)

    Werry, S.M.

    1995-01-01

    This procedure will document the satisfactory operation of the 101-SY tank Camera Purge System (CPS) and 101-SY in tank Color Camera Video Imaging System (CCVIS). Included in the CPRS is the nitrogen purging system safety interlock which shuts down all the color video imaging system electronics within the 101-SY tank vapor space during loss of nitrogen purge pressure

  13. SPECTRAL FILTRATION OF IMAGES BY MEANS OF DISPERSIVE SYSTEMS

    Directory of Open Access Journals (Sweden)

    I. M. Gulis

    2016-01-01

    Full Text Available Instruments for spectral filtration of images are an important element of the systems used in remote sensing, medical diagnostics, in-process measurements. The aim of this study is analysis of the functional features and characteristics of the proposed two image monochromator versions which are based on dispersive spectral filtering. The first is based on the use of a dispersive monochromator, where collimating and camera lenses form a telescopic system, the dispersive element of which is within the intermediate image plane. The second version is based on an imaging double monochromator with dispersion subtraction by back propagation. For the telescopic system version, the spectral and spatial resolutions are estimated, the latter being limited by aberrations and diffraction from the entrance slit. The device has been numerically simulated and prototyped. It is shown that for the spectral bandwidth 10 nm (visible spectral range, the aberration-limited spot size is from 10–20 μm at the image center to about 30 μm at the image periphery for the image size 23–27 mm. The monochromator with dispersion subtraction enables one to vary the spectral resolution (up to 1 nm and higher by changing the intermediate slit width. But the distinctive feature is a significant change in the selected central wavelength over the image field. The considered designs of dispersive image monochromators look very promising due to the particular advantages over the systems based on tunable filters as regards the spectral resolution, fast tuning, and the spectral contrast. The monochromator based on a telescopic system has a simple design and a rather large image field but it also has a limited light throughput due to small aperture size. The monochromator with dispersion subtraction has higher light throughput, can provide high spectral resolution when recording a full data cube in a series of measuring acts for different dispersive element positions. 

  14. Agency Secure Image And Storage Tracking System (ASIST)

    Data.gov (United States)

    US Agency for International Development — Agency Secure Image and Storage Tracking System (Missions): is a Documentum-based user interface developed and maintained by the USAID OCIO (formerly IRM) to improve...

  15. A Total Information Management System For All Medical Images

    Science.gov (United States)

    Ouimette, Donald; Nudelman, Sol; Ramsby, Gale; Spackman, Thomas

    1985-09-01

    A PACS has been designed for the University of Connecticut Health Center to serve all departments acquiring images for diagnosis, surgery and therapy. It incorporates a multiple community communications architecture to provide complete information management for medical images, medical data and departmental administrative matter. The system is modular and expandable. It permits an initial installation for radiology and subsequent expansion to include other departments at the Health Center, beginning with internal medicine, surgery, ophthalmology and dentistry. The design permits sufficient expansion to offer the potential for accepting the additional burden of a hospital information system. Primary parameters that led to this system design were based on the anticipation that departments in time could achieve generating 60 to 90% of their images suited to insertion in a PACS, that a high network throughput for large block image transfers would be essen-tial and that total system reliability was fundamental to success.

  16. Data simulation for the Associated Particle Imaging system

    International Nuclear Information System (INIS)

    Tunnell, L.N.

    1994-01-01

    A data simulation procedure for the Associated Particle Imaging (API) system has been developed by postprocessing output from the Monte Carlo Neutron Photon (MCNP) code. This paper compares the simulated results to our experimental data

  17. Miniaturized Airborne Imaging Central Server System, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — The innovation is a miniaturized airborne imaging central server system (MAICSS). MAICSS is designed as a high-performance-computer-based electronic backend that...

  18. Miniaturized Airborne Imaging Central Server System, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — The innovation is a miniaturized airborne imaging central server system (MAICSS). MAICSS is designed as a high-performance computer-based electronic backend that...

  19. Robustness of an artificially tailored fisheye imaging system with a curvilinear image surface

    Science.gov (United States)

    Lee, Gil Ju; Nam, Won Il; Song, Young Min

    2017-11-01

    Curved image sensors inspired by animal and insect eyes have provided a new development direction in next-generation digital cameras. It is known that natural fish eyes afford an extremely wide field of view (FOV) imaging due to the geometrical properties of the spherical lens and hemispherical retina. However, its inherent drawbacks, such as the low off-axis illumination and the fabrication difficulty of a 'dome-like' hemispherical imager, limit the development of bio-inspired wide FOV cameras. Here, a new type of fisheye imaging system is introduced that has simple lens configurations with a curvilinear image surface, while maintaining high off-axis illumination and a wide FOV. Moreover, through comparisons with commercial conventional fisheye designs, it is determined that the volume and required number of optical elements of the proposed design is practical while capturing the fundamental optical performances. Detailed design guidelines for tailoring the proposed optic system are also discussed.

  20. Suppression of fixed pattern noise for infrared image system

    Science.gov (United States)

    Park, Changhan; Han, Jungsoo; Bae, Kyung-Hoon

    2008-04-01

    In this paper, we propose suppression of fixed pattern noise (FPN) and compensation of soft defect for improvement of object tracking in cooled staring infrared focal plane array (IRFPA) imaging system. FPN appears an observable image which applies to non-uniformity compensation (NUC) by temperature. Soft defect appears glittering black and white point by characteristics of non-uniformity for IR detector by time. This problem is very important because it happen serious problem for object tracking as well as degradation for image quality. Signal processing architecture in cooled staring IRFPA imaging system consists of three tables: low, normal, high temperature for reference gain and offset values. Proposed method operates two offset tables for each table. This is method which operates six term of temperature on the whole. Proposed method of soft defect compensation consists of three stages: (1) separates sub-image for an image, (2) decides a motion distribution of object between each sub-image, (3) analyzes for statistical characteristic from each stationary fixed pixel. Based on experimental results, the proposed method shows an improved image which suppresses FPN by change of temperature distribution from an observational image in real-time.