WorldWideScience

Sample records for berkelium 249

  1. Characterization of berkelium(III) dipicolinate and borate compounds in solution and the solid state.

    Science.gov (United States)

    Silver, Mark A; Cary, Samantha K; Johnson, Jason A; Baumbach, Ryan E; Arico, Alexandra A; Luckey, Morgan; Urban, Matthew; Wang, Jamie C; Polinski, Matthew J; Chemey, Alexander; Liu, Guokui; Chen, Kuan-Wen; Van Cleve, Shelley M; Marsh, Matthew L; Eaton, Teresa M; van de Burgt, Lambertus J; Gray, Ashley L; Hobart, David E; Hanson, Kenneth; Maron, Laurent; Gendron, Frédéric; Autschbach, Jochen; Speldrich, Manfred; Kögerler, Paul; Yang, Ping; Braley, Jenifer; Albrecht-Schmitt, Thomas E

    2016-08-26

    Berkelium is positioned at a crucial location in the actinide series between the inherently stable half-filled 5f(7) configuration of curium and the abrupt transition in chemical behavior created by the onset of a metastable divalent state that starts at californium. However, the mere 320-day half-life of berkelium's only available isotope, (249)Bk, has hindered in-depth studies of the element's coordination chemistry. Herein, we report the synthesis and detailed solid-state and solution-phase characterization of a berkelium coordination complex, Bk(III)tris(dipicolinate), as well as a chemically distinct Bk(III) borate material for comparison. We demonstrate that berkelium's complexation is analogous to that of californium. However, from a range of spectroscopic techniques and quantum mechanical calculations, it is clear that spin-orbit coupling contributes significantly to berkelium's multiconfigurational ground state. PMID:27563098

  2. New berkelium isotope: 242Bk

    International Nuclear Information System (INIS)

    A new isotope of berkelium, 242Bk, was produced with a cross section of approx. 10 μb in reactions of boron on uranium and nitrogen on thorium. It decays by electron capture with a half-life of 7 +- 1.3 minutes. The branching ratio for this isotope for alpha decay is less than 1% and that for spontaneous fission is less than 0.03%. 2 figures, 2 tables

  3. NTC 249 Course Tutorial/ Indigohelp

    OpenAIRE

    raju

    2015-01-01

    For more classes visit www.indigohelp.com   NTC 249 Week 1 DQ 1   NTC 249 Week 1 DQ 2   NTC 249 Week 1 DQ 3   NTC 249 Week 1 Summary   NTC 249 Week 2 DQ 1   NTC 249 Week 2 DQ 2   NTC 249 Week 2 DQ 3   NTC 249 Week 2 Summary   NTC 249 Week 2 Team Assignment Network Design for Acme Manufacturing Network Draft   NTC 249 Week 2 Individual Assignment OSI Model Paper...

  4. 32 CFR 249.6 - Responsibilities.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Responsibilities. 249.6 Section 249.6 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS PRESENTATION OF DoD-RELATED SCIENTIFIC AND TECHNICAL PAPERS AT MEETINGS § 249.6 Responsibilities. (a) The...

  5. 46 CFR 169.249 - Pressure vessels.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Pressure vessels. 169.249 Section 169.249 Shipping COAST... and Certification Inspections § 169.249 Pressure vessels. Pressure vessels must meet the requirements of part 54 of this chapter. The inspection procedures for pressure vessels are contained in...

  6. 46 CFR 249.4 - Eligibility.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Eligibility. 249.4 Section 249.4 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION REGULATIONS AFFECTING SUBSIDIZED VESSELS AND OPERATORS APPROVAL OF UNDERWRITERS FOR MARINE HULL INSURANCE § 249.4 Eligibility. In General. All required marine hull insurance...

  7. 46 CFR 249.12 - Waivers.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Waivers. 249.12 Section 249.12 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION REGULATIONS AFFECTING SUBSIDIZED VESSELS AND OPERATORS APPROVAL OF UNDERWRITERS FOR MARINE HULL INSURANCE § 249.12 Waivers. The provision of this part may be waived in...

  8. 46 CFR 249.11 - Confidentiality.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Confidentiality. 249.11 Section 249.11 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION REGULATIONS AFFECTING SUBSIDIZED VESSELS AND OPERATORS APPROVAL OF UNDERWRITERS FOR MARINE HULL INSURANCE § 249.11 Confidentiality. (a) If the data submitted under this...

  9. 14 CFR 249.4 - Photographic copies.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Photographic copies. 249.4 Section 249.4 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS PRESERVATION OF AIR CARRIER RECORDS General Instructions § 249.4 Photographic copies. (a)...

  10. 7 CFR 249.4 - State Plan.

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SENIOR FARMERS' MARKET NUTRITION PROGRAM (SFMNP) State Agency Eligibility § 249..., and/or nutrition education, as required in § 249.3(d). (2) A description of the State...

  11. 48 CFR 5452.249 - Allocation.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Allocation. 5452.249... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Texts of Provisions and Clauses 5452.249 Allocation. The Defense... contemplated and the contract amount is expected to exceed the small purchase limitation. Allocation (DFSC...

  12. 46 CFR 249.6 - Application procedures.

    Science.gov (United States)

    2010-10-01

    ... OPERATORS APPROVAL OF UNDERWRITERS FOR MARINE HULL INSURANCE § 249.6 Application procedures. (a) MARAD may grant specific approval for underwriters described in § 249.5(c) to participate in the writing of marine hull insurance on MARAD program vessels, only in advance of any actual placement. (b) Only...

  13. 27 CFR 44.249 - Lottery features.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Lottery features. 44.249... Requirements § 44.249 Lottery features. No certificate, coupon, or other device purporting to be or to represent a ticket, chance, share, or an interest in, or dependent on, the event of a lottery shall...

  14. 7 CFR 249.9 - Nutrition education.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Nutrition education. 249.9 Section 249.9 Agriculture... Nutrition education. (a) Goal. Nutrition education shall emphasize the relationship of proper nutrition to... agency shall integrate nutrition education into SFMNP operations and may satisfy nutrition...

  15. 7 CFR 249.7 - Nondiscrimination.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Nondiscrimination. 249.7 Section 249.7 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SENIOR FARMERS' MARKET NUTRITION PROGRAM (SFMNP) Participant Eligibility §...

  16. 7 CFR 249.26 - SFMNP information.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false SFMNP information. 249.26 Section 249.26 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SENIOR FARMERS' MARKET NUTRITION PROGRAM (SFMNP) Miscellaneous Provisions §...

  17. 7 CFR 249.13 - Program income.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Program income. 249.13 Section 249.13 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SENIOR FARMERS' MARKET NUTRITION PROGRAM (SFMNP) State Agency Provisions §...

  18. 7 CFR 249.19 - Investigations.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Investigations. 249.19 Section 249.19 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SENIOR FARMERS' MARKET NUTRITION PROGRAM (SFMNP) Monitoring and Review of...

  19. 7 CFR 249.18 - Audits.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Audits. 249.18 Section 249.18 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SENIOR FARMERS' MARKET NUTRITION PROGRAM (SFMNP) Monitoring and Review of...

  20. 7 CFR 249.15 - Closeout procedures.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Closeout procedures. 249.15 Section 249.15 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SENIOR FARMERS' MARKET NUTRITION PROGRAM (SFMNP) State Agency Provisions §...

  1. Dicty_cDB: SLB249 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SL (Link to library) SLB249 (Link to dictyBase) - - - Contig-U16455-1 SLB249Z (Link... to Original site) - - SLB249Z 727 - - - - Show SLB249 Library SL (Link to library) Clone ID SLB249 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/SL/SLB2-C/SLB249Q.Seq.d/ Representative seq. ID SLB24...9Z (Link to Original site) Representative DNA sequence >SLB249 (SLB249Q) /CSM/SL/SLB2-C/SLB249Q.Seq.d/ XXXXX...NA Score E Sequences producing significant alignments: (bits) Value SLB249 (SLB249Q) /CSM/SL/SLB2-C/SLB249Q.

  2. Dicty_cDB: CHR249 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available CH (Link to library) CHR249 (Link to dictyBase) - - - Contig-U16497-1 - (Link to Original site) - - CHR...249Z 694 - - - - Show CHR249 Library CH (Link to library) Clone ID CHR249 (Link to dicty...iol.tsukuba.ac.jp/CSM/CH/CHR2-C/CHR249Q.Seq.d/ Representative seq. ID - (Link to ...Original site) Representative DNA sequence >CHR249 (CHR249Q) /CSM/CH/CHR2-C/CHR249Q.Seq.d/ XXXXXXXXXXAAATGGT...xxixknqemfnsvvqiiihfmnkiq Frame C: ---w*yfphtn*qmfrlydl*ssfw*l*firxrlprw**myyqcl*ik**cpwcmyklns *mrcyqh**mypill**shr

  3. Dicty_cDB: SSA249 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available utative transporter protein SSA662 (ssa662) mRNA, complete cds. 40 9e-04 2 AC1155...SS (Link to library) SSA249 (Link to dictyBase) - - - Contig-U07966-1 - (Link to Original site) SSA...249F 236 - - - - - - Show SSA249 Library SS (Link to library) Clone ID SSA249 (Link to dicty...iol.tsukuba.ac.jp/CSM/SS/SSA2-C/SSA249Q.Seq.d/ Representative seq. ID - (Link to ...Original site) Representative DNA sequence >SSA249 (SSA249Q) /CSM/SS/SSA2-C/SSA249Q.Seq.d/ ACTTATCGTCACAATTC

  4. Dicty_cDB: VSI249 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available VS (Link to library) VSI249 (Link to dictyBase) - - - Contig-U16236-1 VSI249P (Link to Original site) VSI...249P (Link to Original site) Representative DNA sequence >VSI249 (VSI249Q) /CSM/VS/VSI2-C/VSI2...249F 178 VSI249Z 145 VSI249P 323 - - Show VSI249 Library VS (Link to library) Clone ID VSI...249 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Contig-U16236-1 Original site... URL http://dictycdb.biol.tsukuba.ac.jp/CSM/VS/VSI2-C/VSI249Q.Seq.d/ Representative seq. ID VSI

  5. Oxidation-reduction properties of americium, curium, berkelium, californium, einsteinium and fermium, and thermodynamic consequences for the 5f series

    International Nuclear Information System (INIS)

    The amalgamation of 5f elements from Am to Fm has been studied by using 241Am, 244Cm, 249Bk, 249Cf, 252Cf, 253Es, 254Es, 252Fm and 255Fm with two electrochemical methods, radiocoulometry and radiopolarography, perfectly adapted to investigate extremely diluted solutions when the concentration of electroactive species is as low as 10-16M. The theory of radiocoulometry has been developed in the general cases of reversible and irreversible electrode process. It has been used to interpret the experimental data on the kinetic curves of amalgamation, and to estimate the standard rate constant of the electrode process in complexing medium (citric). On the other hand the radiopolarographic method has been applied to study the mechanism of reduction at the dropping mercury electrode of cations M3+ in aqueous medium to the metal M with formation of amalgam. The results are exploited into two directions: 1- Acquisition of some data concerning the oxidation-reduction properties of elements from Am to Fm. Therefore the standard electrode E0 [M(III-0)] potentials for Bk, Cf and Es, and the standard electrode E0 [M(II-0)] potential for Fm are estimated and the relative stability of each oxidation state (from II to VII) of 5f elements is discussed; 2- Acquisition of unknown thermodynamic data on transcalifornium elements. Correlations between 4f and 5f elements are precised and some divergences appear for the second half of 4f and 5f series (i.e. for 65<=Z<=71 and 97<=Z<=103)

  6. 7 CFR 249.2 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... CHILD NUTRITION PROGRAMS SENIOR FARMERS' MARKET NUTRITION PROGRAM (SFMNP) General § 249.2 Definitions..., Infants and Children authorized by Section 17 of the Child Nutrition Act of 1966 (42 U.S.C. 1786). WIC...) of the Child Nutrition Act of 1966 (42 U.S.C. 1786(m)), to provide resources to women, infants,...

  7. 7 CFR 249.12 - SFMNP costs.

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SENIOR FARMERS' MARKET NUTRITION PROGRAM (SFMNP) State Agency Provisions § 249...-up; (2) The costs associated with the provision of nutrition education that meets the requirements...

  8. 7 CFR 249.25 - Other provisions.

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SENIOR FARMERS' MARKET NUTRITION PROGRAM (SFMNP) Miscellaneous Provisions § 249... (7 U.S.C. 2011, et seq.) and to any other Federal or State food or nutrition assistance program....

  9. 46 CFR 249.2 - Policy.

    Science.gov (United States)

    2010-10-01

    ... UNDERWRITERS FOR MARINE HULL INSURANCE § 249.2 Policy. (a) It is the policy of the Maritime Administration (MARAD) that companies subject to requirements for the placement of marine hull insurance shall be... vessels with ODS or Title XI obligation guarantees to allow the American marine insurance market...

  10. 46 CFR 249.1 - Purpose.

    Science.gov (United States)

    2010-10-01

    ... UNDERWRITERS FOR MARINE HULL INSURANCE § 249.1 Purpose. This part prescribes certain regulations governing the placement of marine hull insurance on vessels built or operated with subsidy or covered by vessel obligation guarantees issued pursuant to Title XI of the Merchant Marine Act, 1936, as amended (Act). (46 U.S.C....

  11. 46 CFR 249.7 - Approval.

    Science.gov (United States)

    2010-10-01

    ... UNDERWRITERS FOR MARINE HULL INSURANCE § 249.7 Approval. (a) Approval of the applicant will be based upon an.... hull insurance market, if U.S. insurers are denied similar access to the hull insurance market in the... to MARAD's attention any discriminatory laws or practices relating to the placement of marine...

  12. 46 CFR 249.5 - Eligibility criteria.

    Science.gov (United States)

    2010-10-01

    ... OPERATORS APPROVAL OF UNDERWRITERS FOR MARINE HULL INSURANCE § 249.5 Eligibility criteria. (a) U.S...'s Insurance Reports, and the amount of insurance does not exceed the limitation on risk prescribed... paragraphs (b) (1) and (2) of this section, may also be eligible to participate in the writing of marine...

  13. 7 CFR 249.3 - Administration.

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SENIOR FARMERS' MARKET NUTRITION PROGRAM (SFMNP) General § 249.3 Administration... availability of OMB Circulars referenced in this section, see 5 CFR 1310.3). The State agency shall...

  14. 32 CFR 249.1 - Purpose.

    Science.gov (United States)

    2010-07-01

    ... scientific and technical papers; and provides criteria for identifying fundamental research activities... OF DoD-RELATED SCIENTIFIC AND TECHNICAL PAPERS AT MEETINGS § 249.1 Purpose. This part amplifies... provides guidance for consideration of national security concerns in the dissemination of scientific...

  15. 32 CFR 249.4 - Policy.

    Science.gov (United States)

    2010-07-01

    ... and public presentation of unclassified contracted fundamental research results. The mechanism for control of information generated by DoD-funded contracted fundamental research in science, technology, and... OF DoD-RELATED SCIENTIFIC AND TECHNICAL PAPERS AT MEETINGS § 249.4 Policy. It is DoD policy to:...

  16. 32 CFR 249.3 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... PRESENTATION OF DoD-RELATED SCIENTIFIC AND TECHNICAL PAPERS AT MEETINGS § 249.3 Definitions. Contracted fundamental research. Includes grants and contracts that are (a) funded by budget Category 6.1 (“Research... Development”) and performed on-campus at a university. The research shall not be considered fundamental...

  17. Mars at Ls 249o: Tharsis

    Science.gov (United States)

    2005-01-01

    5 July 2005 This picture is a composite of Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) daily global images acquired at Ls 249o during a previous Mars year. This month, Mars looks similar, as Ls 249o occurs in mid-July 2005. The picture shows the Tharsis face of Mars. Over the course of the month, additional faces of Mars as it appears at this time of year are being posted for MOC Picture of the Day. Ls, solar longitude, is a measure of the time of year on Mars. Mars travels 360o around the Sun in 1 Mars year. The year begins at Ls 0o, the start of northern spring and southern autumn. Season: Northern Autumn/Southern Spring

  18. 7 CFR 58.249 - Instant nonfat dry milk.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Instant nonfat dry milk. 58.249 Section 58.249... Products Bearing Usda Official Identification § 58.249 Instant nonfat dry milk. (a) Only instant nonfat dry milk manufactured and packaged in accordance with the requirements of this part and with the...

  19. 46 CFR 249.3 - Amounts of insurance.

    Science.gov (United States)

    2010-10-01

    ... OPERATORS APPROVAL OF UNDERWRITERS FOR MARINE HULL INSURANCE § 249.3 Amounts of insurance. MARAD will inform... 46 Shipping 8 2010-10-01 2010-10-01 false Amounts of insurance. 249.3 Section 249.3 Shipping... initial placement and at least annually thereafter, of the minimum amount of insurance required to...

  20. 46 CFR 249.8 - Limitation on risk.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Limitation on risk. 249.8 Section 249.8 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION REGULATIONS AFFECTING SUBSIDIZED VESSELS AND OPERATORS APPROVAL OF UNDERWRITERS FOR MARINE HULL INSURANCE § 249.8 Limitation on risk. (a)...

  1. 46 CFR 249.10 - Non-discrimination policy.

    Science.gov (United States)

    2010-10-01

    ... OPERATORS APPROVAL OF UNDERWRITERS FOR MARINE HULL INSURANCE § 249.10 Non-discrimination policy. To... described in §§ 249.6(b)(3) and 249.7(a), MARAD seeks the assistance of the American marine insurance...) concerning the existence of any discriminatory laws or practices in the marine hull insurance market...

  2. 25 CFR 249.4 - Identification of fishing equipment.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Identification of fishing equipment. 249.4 Section 249.4... FISHING General Provisions § 249.4 Identification of fishing equipment. All fishing gear or other equipment used in the exercise of any off-reservation treaty fishing right shall be marked in such manner...

  3. 42 CFR 24.9 - Removal from the Service.

    Science.gov (United States)

    2010-10-01

    ... in making such answer; and (4) A written decision on the proposal. (c) The decision may be made by an... 42 Public Health 1 2010-10-01 2010-10-01 false Removal from the Service. 24.9 Section 24.9 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR...

  4. 14 CFR 125.249 - Maintenance manual requirements.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Maintenance manual requirements. 125.249 Section 125.249 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... CAPACITY OF 6,000 POUNDS OR MORE; AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Maintenance §...

  5. 7 CFR 249.5 - Selection of new State agencies.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Selection of new State agencies. 249.5 Section 249.5 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SENIOR FARMERS' MARKET NUTRITION PROGRAM (SFMNP) State Agency...

  6. 7 CFR 249.27 - OMB Control Number.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false OMB Control Number. 249.27 Section 249.27 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SENIOR FARMERS' MARKET NUTRITION PROGRAM (SFMNP) Miscellaneous Provisions §...

  7. 7 CFR 249.20 - Claims and penalties.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Claims and penalties. 249.20 Section 249.20 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SENIOR FARMERS' MARKET NUTRITION PROGRAM (SFMNP) Miscellaneous...

  8. 7 CFR 249.21 - Procurement and property management.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Procurement and property management. 249.21 Section 249.21 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SENIOR FARMERS' MARKET NUTRITION PROGRAM...

  9. 7 CFR 249.23 - Records and reports.

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SENIOR FARMERS' MARKET NUTRITION PROGRAM (SFMNP) Miscellaneous Provisions § 249..., delivery receipts, equipment purchases and inventory, nutrition education, fair hearings, and civil...

  10. 75 FR 69870 - Delegation of Authority Under 18 U.S.C. 249

    Science.gov (United States)

    2010-11-16

    ... Part 0 Delegation of Authority Under 18 U.S.C. 249 AGENCY: Department of Justice. ACTION: Final rule... 18 U.S.C. 249, relating to hate crimes, to the Assistant Attorney General for the Civil Rights....S.C. 249. The Shepard-Byrd Act expressly provides that no prosecution under section 249 may...

  11. 7 CFR 249.1 - General purpose and scope.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SENIOR FARMERS' MARKET NUTRITION PROGRAM (SFMNP) General § 249.1 General... carry out the Senior Farmers' Market Nutrition Program (SFMNP). The purposes of the SFMNP are to:...

  12. 46 CFR 249.9 - American market participation.

    Science.gov (United States)

    2010-10-01

    ... OPERATORS APPROVAL OF UNDERWRITERS FOR MARINE HULL INSURANCE § 249.9 American market participation. (a... to the American marine insurance market the opportunity to compete for the placement of marine hull... less than 50 percent of the placement is made with the American marine insurance market, the owners,...

  13. Mars at Ls 249o: Acidalia/Mare Erythraeum

    Science.gov (United States)

    2005-01-01

    12 July 2005 This picture is a composite of Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) daily global images acquired at Ls 249o during a previous Mars year. This month, Mars looks similar, as Ls 249o occurs in mid-July 2005. The picture shows the Acidalia/Mare Erythraeum face of Mars. Over the course of the month, additional faces of Mars as it appears at this time of year are being posted for MOC Picture of the Day. Ls, solar longitude, is a measure of the time of year on Mars. Mars travels 360o around the Sun in 1 Mars year. The year begins at Ls 0o, the start of northern spring and southern autumn. Season: Northern Autumn/Southern Spring

  14. Mars at Ls 249o: Elysium/Mare Cimmerium

    Science.gov (United States)

    2005-01-01

    26 July 2005 This picture is a composite of Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) daily global images acquired at Ls 249o during a previous Mars year. This month, Mars looks similar, as Ls 249o occurred in mid-July 2005. The picture shows the Elysium/Mare Cimmerium face of Mars. Over the course of the month, additional faces of Mars as it appears at this time of year are being posted for MOC Picture of the Day. Ls, solar longitude, is a measure of the time of year on Mars. Mars travels 360o around the Sun in 1 Mars year. The year begins at Ls 0o, the start of northern spring and southern autumn. Season: Northern Autumn/Southern Spring

  15. 48 CFR 52.249-4 - Termination for Convenience of the Government (Services) (Short Form).

    Science.gov (United States)

    2010-10-01

    ... Convenience of the Government (Services) (Short Form). 52.249-4 Section 52.249-4 Federal Acquisition... termination: Termination for Convenience of the Government (Services) (Short Form) (APR 1984) The Contracting... CONTRACT CLAUSES Text of Provisions and Clauses 52.249-4 Termination for Convenience of the...

  16. 5 CFR 532.249 - Minimum rates for hard-to-fill positions.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Minimum rates for hard-to-fill positions. 532.249 Section 532.249 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PREVAILING RATE SYSTEMS Prevailing Rate Determinations § 532.249 Minimum rates for...

  17. 7 CFR 249.22 - Nonprocurement debarment/suspension, drug-free workplace, and lobbying restrictions.

    Science.gov (United States)

    2010-01-01

    ... Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SENIOR FARMERS' MARKET NUTRITION PROGRAM (SFMNP) Miscellaneous Provisions § 249.22 Nonprocurement...

  18. Actinide production in 136Xe bombardments of 249Cf

    International Nuclear Information System (INIS)

    The production cross sections for the actinide products from 136Xe bombardments of 249Cf at energies 1.02, 1.09, and 1.16 times the Coulomb barrier were determined. Fractions of the individual actinide elements were chemically separated from recoil catcher foils. The production cross sections of the actinide products were determined by measuring the radiations emitted from the nuclides within the chemical fractions. The chemical separation techniques used in this work are described in detail, and a description of the data analysis procedure is included. The actinide production cross section distributions from these 136Xe + 249Cf bombardments are compared with the production cross section distributions from other heavy ion bombardments of actinide targets, with emphasis on the comparison with the 136Xe + 248Cm reaction. A technique for modeling the final actinide cross section distributions has been developed and is presented. In this model, the initial (before deexcitation) cross section distribution with respect to the separation energy of a dinuclear complex and with respect to the Z of the target-like fragment is given by an empirical procedure. It is then assumed that the N/Z equilibration in the dinuclear complex occurs by the transfer of neutrons between the two participants in the dinuclear complex. The neutrons and the excitation energy are statistically distributed between the two fragments using a simple Fermi gas level density formalism. The resulting target-like fragment initial cross section distribution with respect to Z, N, and excitation energy is then allowed to deexcite by emission of neutrons in competition with fission. The result is a final cross section distribution with respect to Z and N for the actinide products. 68 refs., 33 figs., 6 tabs

  19. Fusion and quasifission dynamics in the reactions $^{48}$Ca+$^{249}$Bk and $^{50}$Ti+$^{249}$Bk using TDHF

    CERN Document Server

    Umar, A S; Simenel, C

    2016-01-01

    Background: Synthesis of superheavy elements (SHE) with fusion-evaporation reactions is strongly hindered by the quasifission (QF) mechanism which prevents the formation of an equilibrated compound nucleus and which depends on the structure of the reactants. New SHE have been recently produced with doubly-magic $^{48}$Ca beams. However, SHE synthesis experiments with single-magic $^{50}$Ti beams have so far been unsuccessful. Purpose: In connection with experimental searches for $Z=117,119$ superheavy elements, we perform a theoretical study of fusion and quasifission mechanisms in $^{48}$Ca,$^{50}$Ti+$^{249}$Bk reactions in order to investigate possible differences in reaction mechanisms induced by these two projectiles. Methods: The collision dynamics and the outcome of the reactions are studied using unrestricted time-dependent Hartree-Fock (TDHF) calculations as well as the density-constrained TDHF method to extract the nucleus-nucleus potentials and the excitation energy in each fragment. Results: Nucleu...

  20. 17 CFR 249.331 - Form N-CSR, certified shareholder report.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Form N-CSR, certified shareholder report. 249.331 Section 249.331 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... shareholder report. This form shall be used by registered management investment companies to file...

  1. 7 CFR 249.14 - Distribution of funds to State agencies.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Distribution of funds to State agencies. 249.14 Section 249.14 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SENIOR FARMERS' MARKET NUTRITION...

  2. 14 CFR 249.8 - Premature loss or destruction of records.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Premature loss or destruction of records. 249.8 Section 249.8 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION... Premature loss or destruction of records. If records are destroyed or lost before the expiration of...

  3. 48 CFR 52.249-1 - Termination for Convenience of the Government (Fixed-Price) (Short Form).

    Science.gov (United States)

    2010-10-01

    ... Convenience of the Government (Fixed-Price) (Short Form). 52.249-1 Section 52.249-1 Federal Acquisition... Convenience of the Government (Fixed-Price) (Short Form) (APR 1984) The Contracting Officer, by written notice... CONTRACT CLAUSES Text of Provisions and Clauses 52.249-1 Termination for Convenience of the...

  4. 17 CFR 249.332 - Form N-Q, quarterly schedule of portfolio holdings of registered management investment company.

    Science.gov (United States)

    2010-04-01

    ... of portfolio holdings of registered management investment company. 249.332 Section 249.332 Commodity... Securities Exchange Act of 1934 § 249.332 Form N-Q, quarterly schedule of portfolio holdings of registered management investment company. This form shall be used by registered management investment companies,...

  5. 17 CFR 249.322 - Form 12b-25-Notification of late filing.

    Science.gov (United States)

    2010-04-01

    ... CFR Sections Affected, which appears in the Finding Aids section of the printed volume and on GPO...-annual, annual, or transition report on Form N-SAR (§§ 249.330; 274.101) or Form N-CSR (§§ 249.331; 274... to electronic difficulties should comply with either Rule 201 or Rule 202 of Regulation S-T (§...

  6. 249 TP53 mutation has high prevalence and is correlated with larger and poorly differentiated HCC in Brazilian patients

    Directory of Open Access Journals (Sweden)

    Paranaguá-Vezozzo Denise C

    2009-06-01

    Full Text Available Abstract Background Ser-249 TP53 mutation (249Ser is a molecular evidence for aflatoxin-related carcinogenesis in Hepatocellular Carcinoma (HCC and it is frequent in some African and Asian regions, but it is unusual in Western countries. HBV has been claimed to add a synergic effect on genesis of this particular mutation with aflatoxin. The aim of this study was to investigate the frequency of 249Ser mutation in HCC from patients in Brazil. Methods We studied 74 HCC formalin fixed paraffin blocks samples of patients whom underwent surgical resection in Brazil. 249Ser mutation was analyzed by RFLP and DNA sequencing. HBV DNA presence was determined by Real-Time PCR. Results 249Ser mutation was found in 21/74 (28% samples while HBV DNA was detected in 13/74 (16%. 249Ser mutation was detected in 21/74 samples by RFLP assay, of which 14 were confirmed by 249Ser mutant-specific PCR, and 12 by nucleic acid sequencing. All HCC cases with p53-249ser mutation displayed also wild-type p53 sequences. Poorly differentiated HCC was more likely to have 249Ser mutation (OR = 2.415, 95% CI = 1.001 – 5.824, p = 0.05. The mean size of 249Ser HCC tumor was 9.4 cm versus 5.5 cm on wild type HCC (p = 0.012. HBV DNA detection was not related to 249Ser mutation. Conclusion Our results indicate that 249Ser mutation is a HCC important factor of carcinogenesis in Brazil and it is associated to large and poorly differentiated tumors.

  7. Fusion and quasifission dynamics in the reactions 48Ca+249Bk and 50Ti+249Bk using a time-dependent Hartree-Fock approach

    Science.gov (United States)

    Umar, A. S.; Oberacker, V. E.; Simenel, C.

    2016-08-01

    Background: Synthesis of superheavy elements (SHEs) with fusion-evaporation reactions is strongly hindered by the quasifission (QF) mechanism which prevents the formation of an equilibrated compound nucleus and which depends on the structure of the reactants. New SHEs have been recently produced with doubly-magic 48Ca beams. However, SHE synthesis experiments with single-magic 50Ti beams have so far been unsuccessful. Purpose: In connection with experimental searches for Z =117 ,119 superheavy elements, we perform a theoretical study of fusion and quasifission mechanisms in 48Ca,50Ti+249Bk reactions in order to investigate possible differences in reaction mechanisms induced by these two projectiles. Methods: The collision dynamics and the outcome of the reactions are studied using unrestricted time-dependent Hartree-Fock (TDHF) calculations as well as the density-constrained TDHF method to extract the nucleus-nucleus potentials and the excitation energy in each fragment. Results: Nucleus-nucleus potentials, nuclear contact times, masses and charges of the fragments, as well as their kinetic and excitation energies strongly depend on the orientation of the prolate 249Bk nucleus. Long contact times associated with fusion are observed in collisions of both projectiles with the side of the 249Bk nucleus, but not on collisions with its tip. The energy and impact parameter dependencies of the fragment properties, as well as their mass-angle and mass-total kinetic energy correlations are investigated. Conclusions: Entrance channel reaction dynamics are similar with both 48Ca and 50Ti projectiles. Both are expected to lead to the formation of a compound nucleus by fusion if they have enough energy to get in contact with the side of the 249Bk target.

  8. 7 CFR 249.10 - Coupon, market, and CSA program management.

    Science.gov (United States)

    2010-01-01

    ... Section 249.10 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SENIOR FARMERS' MARKET NUTRITION PROGRAM.../or CSA program that is disqualified from participating in the WIC Farmers' Market Nutrition...

  9. 17 CFR 249.218 - Form 18, for foreign governments and political subdivisions thereof.

    Science.gov (United States)

    2010-04-01

    ... Federal Register citations affecting Form 18, see the List of CFR Sections Affected, which appears in the... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Form 18, for foreign... for Registration of Securities on National Securities Exchanges and Similar Matters § 249.218 Form...

  10. 7 CFR 249.8 - Level of benefits and eligible foods.

    Science.gov (United States)

    2010-01-01

    ... 249.8 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SENIOR FARMERS' MARKET NUTRITION PROGRAM (SFMNP..., as long as that level is consistent for all Senior CSA program participants and does not exceed...

  11. Antibiotic Allergic Analysis on 249 Griess Test Negatives%249株革兰阴性杆菌抗生素敏感性分析

    Institute of Scientific and Technical Information of China (English)

    张月明; 刘新焕; 卢立新; 路向东; 步金慧

    2003-01-01

    @@ 随着新的抗生素不断使用,细菌对抗生素的敏感性也发生变化.为了解临床革兰阴性杆菌对抗生素的敏感性,将2000年1月~2001年7月分离的249株革兰阴性杆菌进行抗生素敏感性分析,现报告如下.

  12. Numerical simulation and experimental validation of arc welding of DMR-249A steel

    Directory of Open Access Journals (Sweden)

    Rishi Pamnani

    2016-08-01

    Full Text Available The thermo-mechanical attributes of DMR-249A steel weld joints manufactured by shielded metal arc welding (SMAW and activated gas tungsten arc welding (A-GTAW processes were studied using Finite Element Model (FEM simulation. The thermal gradients and residual stresses were analyzed with SYSWELD software using double ellipsoidal heat source distribution model. The numerically estimated temperature distribution was validated with online temperature measurements using thermocouples. The predicted residual stresses profile across the weld joints was compared with the values experimentally measured using non-destructive techniques. The measured and predicted thermal cycles and residual stress profile was observed to be comparable. The residual stress developed in double sided A-GTAW joint were marginally higher in comparison to five pass SMAW joint due to phase transformation associated with high heat input per weld pass for A-GTAW process. The present investigations suggest the applicability of numerical modeling as an effective approach for predicting the thermo-mechanical properties influenced by welding techniques for DMR-249A steel weld joints. The tensile, impact and micro-hardness tests were carried to compare the welds. Considering benefits of high productivity and savings of labor and cost associated with A-GTAW compared to SMAW process, the minor variation in residual stress build up of A-GTAW joint can be neglected to develop A-GTAW as qualified alternative welding technique for DMR-249A steel.

  13. In vitro and in vivo cytotoxic effects of PRIMA-1 on hepatocellular carcinoma cells expressing mutant p53ser249.

    Science.gov (United States)

    Shi, Hong; Lambert, Jeremy M R; Hautefeuille, Agnes; Bykov, Vladimir J N; Wiman, Klas G; Hainaut, Pierre; Caron de Fromentel, Claude

    2008-07-01

    Hepatocellular carcinoma (HCC) is highly lethal due to limited curative options. In high-incidence regions, such as parts of Africa and Southeastern Asia, >50% of cases carry an AGG to AGT mutation at codon 249 of the TP53 gene, considered as a 'signature' of mutagenesis by aflatoxins. The protein product, p53ser249, may represent a therapeutic target for HCC. The small molecule p53 reactivation and induction of massive apoptosis (PRIMA)-1 has been shown to induce apoptosis in tumour cells by reactivating the transactivation capacity of some p53 mutants. In this study, we have investigated the cytotoxic effects of PRIMA-1 on HCC cells expressing p53ser249. In p53-null Hep3B cells, over-expression of p53ser249 or p53gln248 by stable transfection increased the cytotoxicity of PRIMA-1 at 50 muM. Furthermore, PRIMA-1 treatment delayed the growth of p53ser249-expressing Hep3B cells xenografted in severe combined immunodeficiency mice. However, PRIMA-1 did not restore wild-type DNA binding and transactivation activities to p53ser249 or to p53gln248 in Hep3B cells. Moreover, in PLC/PRF/5, a HCC cell line constitutively expressing p53ser249, small interfering RNA (siRNA) silencing of the mutant increased the cytotoxic effect of PRIMA-1. These apparently contradictory effects can be reconciled by proposing that p53ser249 exerts a gain-of-function effect, which favours the survival of HCC cells. Thus, both inhibition of this effect by PRIMA-1 and removal of the mutant by siRNA can lead to the decrease of survival capacity of HCC cells. PMID:18048389

  14. Host competence and helicase activity differences exhibited by West Nile viral variants expressing NS3-249 amino acid polymorphisms.

    Directory of Open Access Journals (Sweden)

    Stanley A Langevin

    Full Text Available A single helicase amino acid substitution, NS3-T249P, has been shown to increase viremia magnitude/mortality in American crows (AMCRs following West Nile virus (WNV infection. Lineage/intra-lineage geographic variants exhibit consistent amino acid polymorphisms at this locus; however, the majority of WNV isolates associated with recent outbreaks reported worldwide have a proline at the NS3-249 residue. In order to evaluate the impact of NS3-249 variants on avian and mammalian virulence, multiple amino acid substitutions were engineered into a WNV infectious cDNA (NY99; NS3-249P and the resulting viruses inoculated into AMCRs, house sparrows (HOSPs and mice. Differential viremia profiles were observed between mutant viruses in the two bird species; however, the NS3-249P virus produced the highest mean peak viral loads in both avian models. In contrast, this avian modulating virulence determinant had no effect on LD50 or the neurovirulence phenotype in the murine model. Recombinant helicase proteins demonstrated variable helicase and ATPase activities; however, differences did not correlate with avian or murine viremia phenotypes. These in vitro and in vivo data indicate that avian-specific phenotypes are modulated by critical viral-host protein interactions involving the NS3-249 residue that directly influence transmission efficiency and therefore the magnitude of WNV epizootics in nature.

  15. Dipole Analysis of 249 High-Z SCP Union Supernovae According to the Expansion Center Model

    CERN Document Server

    Lorenzi, Luciano

    2011-01-01

    The topic of the paper is a preliminary analysis of 1743 data calculated for 249 High-z SCP Union supernovae, according to the expansion center model. The analysis of the ECM data set in Hubble units begins with 13 listed normal points corresponding to 13 z-bin samples at as many Hubble depths. Here the novel finding is a resulting clear drop in the average scattering of the SNe Ia absolute magnitudes M with the ECM Hubble depth D, after using the average trend computed in paper IX and here reconfirmed. Other correlations of the M scattering with the position in the sky are proposed as pointers for future investigations. Consequently, 13 ECM dipole tests on the 13 z-bin samples were carried out both with unweighed and weighed fittings. A further check was made through another ECM dipole test on the same 13 z bins, with Hubble depths D obtained by assuming M= according to paper IX and X. In conclusion the analysis of 249 SCP SNe confirms once again the expansion center model at any Hubble depth, including a s...

  16. p53 ser249突变对小鼠EF细胞周期和凋亡的影响%Effect of p53 249 Arg to Ser mutation on cell cycle and apoptosis in mouse EF cells

    Institute of Scientific and Technical Information of China (English)

    吴智群; 李庆霞; 李臻; 于翠娟; 罗亚宁

    2009-01-01

    Objective To explore the effect of p53 249 Arg to Ser mutation on function of p53 in mouse EF cells.Methods Arg to Ser mutation was introduced into the p53 249 code by knock-in method.The ES cells with p53 249 Arg to Ser mutation were selected according to the homologues-recombination with RCR and Southern blot.The positive ES cells without a selection marker were injected into blastocysts recovered from Hprt-/-mice,which were derived from Hprt-deficient ES cells.The injected blastocysts then were implanted into pseudopregnant females.At embryonic day 14,MEFs were recovered from the embryos and cultured under the selection of HAT (0.016 mg of hypoxanthine/ml,0.01 mM aminopterin,0.0048 mg of thymidine/ml) and the cell cycle,apoptosis,and the relative protein expression were analyzed by flow cytometry and Western blot.Results 1) The EF cells with 249 Arg to Ser mutation were more resistant to the UV induced cell cycle arrest compared to the wild type EF cell (P<0.05).2) The EF cells with 249 Arg to Ser mutation were more resistant to the UV induced apoptosis compared to the wild type ES cell (P<0.05).3) The mutation did not affect the expression of p53 after UV but decrease the expression of BAX and p21 after UV.Conclusion Thep53 249 Arg to Ser mutation can disable the function of p53 but do not change the expression of p53 in EF cells.%目的 研究p53 249编码子突变对小鼠EF细胞p53功能和信号传导的影响.方法 利用基因打靶技术在小鼠ES细胞p53基因249编码子中引入点突变.使编码子249由Arg变成Ser,根据同源重组规律采用PCR或Southern方法筛选带有p53 249突变的阳性ES细胞,并通过测序确定该ES细胞的p53 249编码子已经由Arg变成Ser,然后将含突变而不含筛选标记的ES细胞微注射到从Hprt-/-小鼠收集的囊胚中,将注射过的囊胚植入假孕的雌性小鼠子宫,到第14天取小鼠胚胎EF细胞,用含HAT的培养液[DMEM含10%FCS,glutamine,antibiotics,50 mM mecaptoethanol

  17. 17 CFR 249.318 - Form 18-K, annual report for foreign governments and political subdivisions thereof.

    Science.gov (United States)

    2010-04-01

    .... Editorial Note: For Federal Register citations affecting Form 18-K, see the List of CFR Sections Affected... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Form 18-K, annual report for... of 1934 § 249.318 Form 18-K, annual report for foreign governments and political subdivisions...

  18. 17 CFR 249.1001 - Form SIP, for application for registration as a securities information processor or to amend such...

    Science.gov (United States)

    2010-04-01

    ... Note: For Federal Register citations affecting Form SIP, see the List of CFR Sections Affected, which... registration as a securities information processor or to amend such an application or registration. 249.1001..., SECURITIES EXCHANGE ACT OF 1934 Form for Registration of, and Reporting by Securities Information...

  19. 75 FR 19880 - Safety Zone; BW PIONEER at Walker Ridge 249, Outer Continental Shelf FPSO, Gulf of Mexico

    Science.gov (United States)

    2010-04-16

    ... natural gas, and thereby protects the safety of life, property, and the environment. DATES: This rule is... of natural gas and increase the safety of life, property, and the environment in the Gulf of Mexico... SECURITY Coast Guard 33 CFR Part 147 RIN 1625-AA00 Safety Zone; BW PIONEER at Walker Ridge 249,...

  20. Results from the First {sup 249}Cf + {sup 48}Ca Experiment

    Science.gov (United States)

    Oganessian, Y. T.; Utyonkov, V. K.; Lobanov, Y. V.; Abdullin, F. S.; Polyakov, A. N.; Shirokovsky, I. V.; Tsyganov, Y. S.; Mezentsev, A. N.; Iliev, S.; Subbotin, V. G.; Sukhov, A. M.; Ivanov, O. V.; Voinov, A. A.; Subotic, K.; Zagrebaev, V. I.; Itkis, M. G.; Moody, K. J.; Wild, J. F.; Stoyer, M. A.; Stoyer, N. J.; Laue, C. A.; Shaughnessy, D. A.; Patin, J. B.; Lougheed, R. W.

    2003-02-03

    The present paper reports the results of an attempt aimed at the synthesis of element 118 in the reaction {sup 249}Cf({sup 48}Ca,3n){sup 294}118. The experiment was performed employing the Dubna Gas-filled Recoil Separator and the U400 heavy-ion cyclotron at FLNR, JINR, Dubna. In the course of a 2300-hour irradiation of an enriched {sup 249}Cf target (0.23 mg/cm{sup 2}) with a beam of 245-MeV {sup 48}Ca ions, we accumulated a total beam dose of 2.5 x 10{sup 19} ions. We detected two events that may be attributed to the formation and decay of nuclei with Z=118. For one event, we observed a decay chain of two correlated {alpha}-decays with corresponding energies and correlation times of E{sub {alpha}1} = 11.65 {+-} 0.06 MeV, t{sub {alpha}1} = 2.55 ms and E{sub {alpha}2} = 10.71 {+-} 0.17 MeV, t{sub {alpha}2} = 42.1 ms and, finally, a spontaneous fission with the sum of the kinetic energies of the fission fragments E{sub tot} = 207 MeV (TKE {approx} 230 MeV) and t{sub SF} = 0.52 s. In the second event chain, the recoil nucleus decayed into two fission fragments with E{sub tot} = 223 MeV (TKE {approx} 245 MeV) 3.16 ms later, without intervening {alpha} decays. The probabilities that these events were caused by the chance correlations of unrelated signals are negligible. Both events were observed at an excitation energy of the compound nucleus {sup 297}118 of E* = 30.0 {+-} 2.4 MeV, close to the expected maximum of the 3n-evaporation channel. The relationship between the decay energy Q{sub {alpha}} and decay period T{sub {alpha}} shows that sequential {alpha}-transitions in the first event correspond to the decay chain with Z = 118{_}116{_}114. Decay characteristics of the newly observed nuclides are compared with radioactive decay properties of the even-even isotopes with Z = 116, 114 and 112 previously produced in the reactions {sup 244}Pu, {sup 248}Cm + {sup 48}Ca and calculations made in various nuclear models.

  1. Essentials and guidelines for clinical medical physics residency training programs: executive summary of AAPM Report Number 249.

    Science.gov (United States)

    Prisciandaro, Joann I; Willis, Charles E; Burmeister, Jay W; Clarke, Geoffrey D; Das, Rupak K; Esthappan, Jacqueline; Gerbi, Bruce J; Harkness, Beth A; Patton, James A; Peck, Donald J; Pizzutiello, Robert J; Sandison, George A; White, Sharon L; Wichman, Brian D; Ibbott, Geoffrey S; Both, Stefan

    2014-01-01

    There is a clear need for established standards for medical physics residency training. The complexity of techniques in imaging, nuclear medicine, and radiation oncology continues to increase with each passing year. It is therefore imperative that training requirements and competencies are routinely reviewed and updated to reflect the changing environment in hospitals and clinics across the country. In 2010, the AAPM Work Group on Periodic Review of Medical Physics Residency Training was formed and charged with updating AAPM Report Number 90. This work group includes AAPM members with extensive experience in clinical, professional, and educational aspects of medical physics. The resulting report, AAPM Report Number 249, concentrates on the clinical and professional knowledge needed to function independently as a practicing medical physicist in the areas of radiation oncology, imaging, and nuclear medicine, and constitutes a revision to AAPM Report Number 90. This manuscript presents an executive summary of AAPM Report Number 249. PMID:24892354

  2. Energy levels of 249Bk populated in the α decay of 99253Es and β- decay of 96249Cm

    International Nuclear Information System (INIS)

    The level structure of 249Bk has been investigated by measuring the γ-ray spectra of an extremely pure 253Es sample obtained by milking this nuclide from 253Cf source material produced in the High Flux Isotope Reactor at Oak Ridge National Laboratory. Additional information on the 249Bk levels was obtained from the β--decay study of 249Cm, produced by neutron irradiation of 248Cm. Using the results of the present study together with the data from previous 248Cm(α,t) and 248Cm(3He,d) reactions, the following single-particle states have been identified in 249Bk: 7/2+[633], 0.0 keV; 3/2-[521], 8.78 keV; 1/2+[400], 377.55 keV; 5/2+[642], 389.17 keV; 1/2-[530], 569.20 keV; 1/2-[521], 643.0 keV; 5/2-[523], 672.9 keV; and 9/2+[624], 1075.1 keV. Four vibrational bands were identified at 767.9, 932.2, 1150.7, and 1223.0 keV with tentative assignments of {7/2+ [633] x1-}9/2-, {7/2+ [633] x 0-}7/2-, {7/2+ [633] x 1-}5/2-, and {7/2+ [633] x 0+}7/2+, respectively. A band at 899.9 keV was observed in γ-γ coincidence measurements and given a tentative spin assignment of 3/2. It is possibly associated with a 2- phonon coupled to the ground state, with configuration {7/2+ [633] x 2-}3/2-. Three levels at 624.3, 703.5, and 769.1 keV were assigned spins of 5/2, 7/2, and 9/2, respectively. These could be the members of the 3/2+ [651] band, expected in this energy region

  3. 浙江省249例聋校学生听力状况及病因学调查%An Etiological Study on Hearing Loss of 249 Deaf Students in Zhejiang Province

    Institute of Scientific and Technical Information of China (English)

    管锐瑞; 王晓艾; 王一鸣; 王永华

    2014-01-01

    目的:探讨浙江省聋校学生听力损失的病因、听力状况以及语言交流能力。明确该地区不同致聋因素,为因地制宜的开展耳聋的预防、干预等措施奠定基础,从而为将来开展从分子水平上进行耳聋的基因诊断和遗传咨询提供临床依据。方法采用调查问卷,听力测试等方法对浙江省249名聋校学生进行听力状况及病因学调查,并对其中佩戴助听器且有语言能力的56人进行言语测试。结果聋儿均为感应神经性聋,极重度聋占79.12%(197/249),重度聋占17.27%(43/249),中重度聋占3.21%(8/249),中度聋占0.40%(1/249)。先天性聋儿中,家族遗传性聋占7.23%(18/249),后天性聋儿中,药物性聋占36.54%(91/249),其中庆大霉素所占比例最高(31.87%)。佩戴助听器且有语言能力的56例聋儿,单音节词的平均正确率为62.1%,双音节词平均正确率为58.7%。结论聋校学生听力损失以极度聋、重度聋为多数,使用耳毒性药物是导致耳聋的主要原因;对聋儿进行早期诊断、早期佩戴助昕器、早期进行听力语言训练是使聋儿能够正常交流,融入主流社会的关键。%Objective To study the etiology, the hearing status and languagecommunication skills of the deaf students in Zhejiang province and to get the different factors of the deafness in the area in order to lay the foundation for getting more information about gene diagnosis and genetic counseling from the molecular level. Methods A total number of the 249 deaf students in Zhejiang province were examined with audiometer、investigated through questionnaire and other ways. Among them, 56 people of wearing hearing AIDS also had speech audiometry. Results The defect of the students is generally sensorineural, most of them are nonsyndromic deafness. The degrees of deafness could be ascertained with 197 (79.12%) students of profound deafness, 43 (17.27%) students

  4. Synthesis of the isotopes of elements 118 and 116 in the 249Cf and 245Cm+48Ca fusion reactions

    Energy Technology Data Exchange (ETDEWEB)

    Oganessian, Y T; Utyonkov, V K; Lobanov, Y V; Abdullin, F S; Polyakov, A N; Sagaidak, R N; Shirokovsky, I V; Tsyganov, Y S; Voinov, A A; Gulbekian, G G; Bogomolov, S L; Gikal, B N; Mezentsev, A N; Iliev, S; Subbotin, V G; Sukhov, A M; Subotic, K; Zagrebaev, V I; Vostokin, G K; Itkis, M G; Moody, K J; . Patin, J B; Shaughnessy, D A; Stoyer, M A; Stoyer, N J; Wilk, P A; Kenneally, J M; Landrum, J H; Wild, J F; Lougheed, R W

    2006-01-31

    The decay properties of {sup 290}116 and {sup 291}116, and the dependence of their production cross sections on the excitation energies of the compound nucleus, {sup 293}116, have been measured in the {sup 245}Cm({sup 48}Ca,xn){sup 293-x}116 reaction. These isotopes of element 116 are the decay daughters of element 118 isotopes, which are produced via the {sup 249}Cf+{sup 48}Ca reaction. They performed the element 118 experiment at two projectile energies, corresponding to {sup 297}118 compound nucleus excitation energies of E* = 29.2 {+-} 2.5 and 34.4 {+-} 2.3 MeV. During an irradiation with a total beam dose of 4.1 x 10{sup 19} {sup 48}Ca projectiles, three similar decay chains consisting of two or three consecutive {alpha} decays and terminated by a spontaneous fission (SF) with high total kinetic energy of about 230 MeV were observed. The three decay chains originated from the even-even isotope {sup 294}118 (E{sub {alpha}} = 11.65 {+-} 0.06 MeV, T{sub {alpha}} = 0.89{sub -0.31}{sup +1.07} ms) produced in the 3n-evaporation channel of the {sup 249}Cf+{sup 48}Ca reaction with a maximum cross section of 0.5{sub -0.3}{sup +1.6} pb.

  5. Detection of human papilloma virus in 249 cases of patients with genital warts%249例生殖器疣患者人乳头瘤病毒检测分析

    Institute of Scientific and Technical Information of China (English)

    李蕾; 邹先彪

    2016-01-01

    Objective To investigate the distribution of human papilloma virus (HPV) genotypes from outpatients with genital wart in Beijing.Method Flow cytometry HPV genotyping technique were used to detect and identify HPV genotypes from individual lesions. Result Among 249 cases of genital warts, 232 (93.17%) were DNA HPV positive. The positive rate of HPV single type was 63.86%, the positive rate of multiple type of HPV was 36.14%. The infection rate of low-risk HPV was 55.4%, in which HPV6 and HPV11 were the most popular genotypes. HPV16, HPV58, HPV18 were the most prevalent high-risk genotypes.Conclusion The peak of HPV infection concentrates in sexually active population younger than 40 years old. HPV6, HPV11 and HPV16 are the predominant genotypes for genital wart in Beijing.%目的:调查生殖器疣患者人乳头瘤病毒(human papilloma virus,HPV)感染特点,为HPV感染的预防和诊治提供理论依据。方法采用流式荧光HPV基因分型技术检测249例生殖器疣患者皮损组织中HPV的型别。结果249例生殖器疣患者中,232例(93.17%)HPV DNA阳性。单一型感染率为63.86%,复合型感染率为36.14%。低危型HPV阳性率为55.4%,其中以HPV6、HPV11最多;高危型中以HPV16最多,其次为HPV58、HPV18型。结论本地区生殖器HPV感染集中于40岁以下性活跃期的人群。以单一型感染为主,最常见HPV6、HPV11和HPV16型感染。

  6. Factors influencing resuscitation and growth of heat injured Listeria monocytogenes 13-249 in sous vide cooked beef.

    Science.gov (United States)

    Hansen, T B; Knøchel, S

    2001-01-22

    The growth of Listeria monocytogenes 13-249 in vacuum-packed, minced beef was investigated as a function of degree of heat injury (including no injury i.e. uncooked beef), growth phase (logarithmic and late stationary phase), pH (5.6 and 6.2), and storage temperature (3, 10 and 20 degrees C) during a storage period of 30 days. Late logarithmic and late stationary phase cultures of L. monocytogenes 13-249 showed similar growth in refrigerated, vacuum-packed, raw minced beef with a high pH (6.2). In normal pH (5.6) beef there was no growth at 3 degrees C while growth at 10 and 20 degrees C was only observed for logarithmic phase cultures. Heat injured late stationary phase cultures with 95-99.9% injured cells in the surviving population (as measured by differential plating on enriched vs. selective media after sous vide cooking) did not grow or repair sublethal injuries in sous vide cooked beef at 3 degrees C while repair and growth took place at 10 as well as at 20 degrees C. In logarithmic phase cultures heat injury occurred very rapidly and > or = 99.9% heat injury was observed in all trials in spite of much lower pasteurization values and fewer log10 reductions compared with late stationary phase cultures. Regardless of growth phase, all cultures where a high degree of heat injury (> or = 99.9%) was observed, did not subsequently grow in the beef product at 3 or 10 degrees C within 30 days. Growth of heat injured cultures preexposed to heat shock (46 degrees C, 30 min) or slowly rising temperatures (0.3 degrees C min(-1)) before heat injury was also investigated. Heat shocked or heat adapted cultures generally responded in the same manner as non-stressed cultures (no growth at 3 degrees C) except that a longer lag phase was observed in beef processed at slowly rising temperatures and in normal pH beef at 10 degrees C. Although processing at slowly rising temperatures may slightly increase the survival of L. monocytogenes 13-249 in cooked beef, there seem to be no

  7. Factors influencing resuscitation and growth of heat injured Listeria monocytogenes 13-249 in sous vide cooked beef.

    Science.gov (United States)

    Hansen, T B; Knøchel, S

    2001-01-22

    The growth of Listeria monocytogenes 13-249 in vacuum-packed, minced beef was investigated as a function of degree of heat injury (including no injury i.e. uncooked beef), growth phase (logarithmic and late stationary phase), pH (5.6 and 6.2), and storage temperature (3, 10 and 20 degrees C) during a storage period of 30 days. Late logarithmic and late stationary phase cultures of L. monocytogenes 13-249 showed similar growth in refrigerated, vacuum-packed, raw minced beef with a high pH (6.2). In normal pH (5.6) beef there was no growth at 3 degrees C while growth at 10 and 20 degrees C was only observed for logarithmic phase cultures. Heat injured late stationary phase cultures with 95-99.9% injured cells in the surviving population (as measured by differential plating on enriched vs. selective media after sous vide cooking) did not grow or repair sublethal injuries in sous vide cooked beef at 3 degrees C while repair and growth took place at 10 as well as at 20 degrees C. In logarithmic phase cultures heat injury occurred very rapidly and > or = 99.9% heat injury was observed in all trials in spite of much lower pasteurization values and fewer log10 reductions compared with late stationary phase cultures. Regardless of growth phase, all cultures where a high degree of heat injury (> or = 99.9%) was observed, did not subsequently grow in the beef product at 3 or 10 degrees C within 30 days. Growth of heat injured cultures preexposed to heat shock (46 degrees C, 30 min) or slowly rising temperatures (0.3 degrees C min(-1)) before heat injury was also investigated. Heat shocked or heat adapted cultures generally responded in the same manner as non-stressed cultures (no growth at 3 degrees C) except that a longer lag phase was observed in beef processed at slowly rising temperatures and in normal pH beef at 10 degrees C. Although processing at slowly rising temperatures may slightly increase the survival of L. monocytogenes 13-249 in cooked beef, there seem to be no

  8. Analysis on Influence Factor and Prediction of Plexiglas GS 249 Fatigue Limit%GS249有机玻璃疲劳极限的影响因素分析及预测

    Institute of Scientific and Technical Information of China (English)

    辛艳粉; 王泓; 陈新文; 乙晓伟

    2012-01-01

    在不同应力比条件下,对不同应力集中系数的GS249有机玻璃疲劳试样进行疲劳试验.使用升降法获得材料的疲劳极限.分析获得了加载参数及形状参数对有机玻璃疲劳极限影响的相关规律.建立了基于应力比和应力集中系数的预测有机玻璃疲劳极限的方法模型.结果表明:随着应力比的增加,疲劳极限呈下降趋势;疲劳极限随着应力集中系数的增加而线性降低.随着应力集中系数的降低,疲劳极限受应力比的影响越大.%The fatigue tests of Plexiglas GS 249 with different stress concentration factors were conducted in different stress R-ratio conditions, and obtained the material fatigue limits using the up-down method. The method model to predict the fatigue limits of Plexiglas are established based on the stress /f-ratio and stress concentration factors. The related laws of the loading parameters and shape parameters affecting the fatigue limits of Plexiglas were obtained in the analysis. The results show that, the fatigue limits have a downward trend with the increase of stress R-ratio, the fatigue limits linearly reduce as the stress concentration factors increase, and the fatigue limits are impacted greater by the stress /?-ratio with the reduction of stress concentration factors.

  9. Analysis of high risk factors and head MRI in 249 children with spastic cerebral palsy%249例痉挛性脑瘫患儿高危因素与 MRI分析

    Institute of Scientific and Technical Information of China (English)

    廖小艳; 田新姿

    2014-01-01

    Objective:To sum up the common high risk factors of children with spastic cerebral palsy and different types of magnetic results. Methods:The clinical data of 249 children with spastic cerebral palsy were analyzed retrospectively. Results: The high risk factors of 80% children patients were multifactors. The common factors included:(1) prenatal:intrauterine distress, threat-ened abortion, cord around neck, medical history, and meconium contamination;(2) intrapartum:anoxia, premature birth, low body weight, premature rupture of placenta, and delayed delivery;and (3) postpartum:jaundice, intracranial hemorrhage, and pneumonia of newborn. The abnormal rate of head MRI result was 90. 7%, in which periventricular leukomalacia was the common type (50. 4%) . Conclusions: The common high risk factors of children with spastic cerebral palsy are anoxia, premature birth, low body weight, pathologic jaundice. The head MRI has a high probability to found the abnormal. Common risk factors for different types of magnetic results are different.%目的::总结痉挛型脑瘫患儿常见的高危因素及头颅MRI改变。方法:对249例痉挛型脑瘫患儿资料进行回顾性分析。结果:80%的患儿高危因素为多因素。最常见的有:①产前为胎儿宫内窘迫、先兆流产、脐带绕颈、用药史、胎粪污染;②产时依次为缺氧、早产、低体重、胎盘早破、产程延长;③产后为黄疸、颅内出血、新生儿肺炎。头颅MRI检查异常率为90.7%,其中脑室周围白质异常占50.4%。结论:痉挛型脑瘫患儿常见的高危因素为缺氧、早产、低体重、病理性黄疸,头颅MRI改变检出率高,且依致病因素不同而表现各异。

  10. 莫高窟第249窟窟顶壁画图像学研究%A Research on the Top Murals of Cave No. 249 in the Mogao Grottoes Based on Iconology

    Institute of Scientific and Technical Information of China (English)

    岳锋

    2012-01-01

    Although the scholars at home and abroad have studied the main images on the top murals of Cave No. 249 in the Mogao Grottoes from different perspectives, they couldn't reach an agreement. At present, no conclusion can be made on these images in academic circle. However, by integrating the predecessor' s research achievement and studying the combination principles of these images at a macro level, an illustration of iconology may take its initial shape based on the theory of iconology proposed by Erwin Panofsky. To sum up, the "combination" of the images from the different cultural origins converged into a whole and demonstrated a shared signifieanee concealed in the images. Namely, it is a cosmic illusion of a fusion of the exotic Buddhism thought and local Taoism thought.%围绕莫高窟第249窟窟顶壁画的主要图像,中外学者采用了不同的研究方法,从不同的视角进行了深入研究,形成了不同的结论。目前,学术界对这些图像尚不能形成统一的定论,但是基于欧文·帕诺夫斯基的图像学研究三个阶段的基本理论,综合前人的研究成果,从宏观上把握这些图像的组合原则,可以初步形成一个图像学的解释:不同文化渊源图像的“混用”汇聚成一个整体,共同表达了一个隐藏在图像背后的意义,即一个融合了外来佛教思想和本土道教思想的古代敦煌人心中的宇宙幻象。

  11. Expression of the benign HEXA mutations, Arg247Trp and Arg249Trp, associated with beta-hexosaminidase A pseudodeficiency

    Energy Technology Data Exchange (ETDEWEB)

    Cao, Z.; Petroulakis, E.; Salo, T. [Univ. of Manitoba (Canada)] [and others

    1994-09-01

    {beta}-Hexosaminidase (Hex A) is a heterodimer of {alpha} and {beta} subunits encoded by the HEXA and HEXB genes, respectively. Mutations in the HEXA gene typically cause Tay-Sachs disease or less severe forms of G{sub M2} gangliosidosis. However, two benign mutations (Arg247Trp and Arg249Trp) in the {alpha}-subunit of Hex A account for Hex A deficiency in {approximately}36% of non-Jewish enzyme-defined Tay-Sachs disease carriers. These mutations do not result in any apparent clinical phenotype in individuals who are genetic compounds with a second disease-causing mutation. We expressed the {alpha}-subunit harboring each of the benign mutations separately to study activity toward the synthetic substrate, 4-MUGS, for comparison to activity from enzymes containing mutations associated with other forms of G{sub M2} gangliosidosis. The C739T (Arg247Trp;benign), C745T (Arg 249Trp; benign), G805A (Gly269Ser; adult-onset), G749A (Gly250Asp; juvenile), and C508T (Arg170Trp; infantile) mutations were introduced into the {alpha}-subunit cDNA. These were transfected alone, or with the {beta}-subunit cDNA, to generate Hex S ({alpha}{alpha}) or Hex A ({alpha}{beta}), respectively. The activities were monitored using 4-MUGS, and the levels of {alpha}-subunit protein were assessed by Western blotting. Repeated experiments show that the benign mutations produce approximately 35% of normal Hex S and 40% of normal Hex A activity. This level is much higher than that of Hex A harbouring the Gly169Ser adult-onset mutation (12%). A sequential decrease in expressed Hex A activity is observed as mutations associated with more severe phenotypes are expressed. The benign mutations also result in lower levels of mature {alpha}-subunit protein compared to normal, and slightly reduced levels of {alpha}-subunit precursor protein. The Hex A deficiency resulting from benign mutations is not as great as that associated with disease-causing mutations.

  12. Effects of the TP53 p.R249S mutant on proliferation and clonogenic properties in human hepatocellular carcinoma cell lines: interaction with hepatitis B virus X protein.

    Science.gov (United States)

    Gouas, Doriane A; Shi, Hong; Hautefeuille, Agnès H; Ortiz-Cuaran, Sandra L; Legros, Pénélope C; Szymanska, Katarzyna J; Galy, Olivier; Egevad, Lars A; Abedi-Ardekani, Behnoush; Wiman, Klas G; Hantz, Olivier; Caron de Fromentel, Claude; Chemin, Isabelle A; Hainaut, Pierre L

    2010-08-01

    Aflatoxin B(1) (AFB(1)) is a risk factor for hepatocellular carcinoma (HCC) in many low-resource countries. Although its metabolites bind at several positions in TP53, a mutation at codon 249 (AGG to AGT, arginine to serine, p.R249S) accounts for 90% of TP53 mutations in AFB(1)-related HCC. This specificity suggests that p.R249S confers a selective advantage during hepatocarcinogenesis. Using HCC cell lines, we show that p.R249S has lost the capacity to bind to p53 response elements and to transactivate p53 target genes. In p53-null Hep3B cells, stable transfection of p.R249S or of another mutant, p.R248Q, did not induce significant changes in cell proliferation and survival after cytotoxic stress. In contrast, in a cell line that constitutively expresses both p.R249S and the hepatitis B virus antigen HBx (PLC/PRF/5), silencing of either p.R249S or HBx by RNA interference slowed down proliferation, with no additive effects when both factors were silenced. Furthermore, the two proteins appear to form a complex. In human HCC samples, mutation at codon 249 did not correlate with p.R249S protein accumulation or HBx truncation status. We suggest that p.R249S may contribute to hepatocarcinogenesis through interaction with HBx, conferring a subtle growth advantage at early steps of the transformation process, but that this interaction is not required for progression to advanced HCC. PMID:20538734

  13. X-ray nova MAXI J1828-249. Evolution of the broadband spectrum during its 2013-2014 outburst

    CERN Document Server

    Grebenev, S A; Burenin, R A; Krivonos, R A; Mescheryakov, A V

    2016-01-01

    Based on data from the SWIFT, INTEGRAL, MAXI/ISS orbital observatories, and the ground-based RTT-150 telescope, we have investigated the broadband (from the optical to the hard X-ray bands) spectrum of the X-ray nova MAXI J1828-249 and its evolution during the outburst of the source in 2013-2014. The optical and infrared emissions from the nova are shown to be largely determined by the extension of the power-law component responsible for the hard X-ray emission. The contribution from the outer cold regions of the accretion disk, even if the X-ray heating of its surface is taken into account, turns out to be moderate during the source's "high" state (when a soft blackbody emission component is observed in the X-ray spectrum) and is virtually absent during its "low" ("hard") state. This result suggests that much of the optical and infrared emissions from such systems originates in the same region of main energy release where their hard X-ray emission is formed. This can be the Compton or synchro-Compton radiati...

  14. Analysis of 249 Cases With Nutritional and Iron Deficiency Anemia%婴、幼儿营养性缺铁性贫血249例相关因素分析

    Institute of Scientific and Technical Information of China (English)

    郑建梅; 杨道科

    2009-01-01

    目的 探讨不同月龄婴、幼儿的营养性缺铁性贫血(nutritional iron deficiency anemia)发生情况及其相关因素.方法 选择2004年1月1日至2006年12月31日在郑州市妇幼保健院儿童保健门诊接受规范4∶2∶1保健的1 254例1~6个月(A组,n=540)、6~12个月(B组,n=360)、12~18个月(C组,n=354)儿童为研究对象(本研究遵循的程序符合郑州市妇幼保健院人体试验委员会所制定的伦理学标准,得到该委员会批准,分组征得受试对象监护人的知情同意,并与其签署临床研究知情同意书).对其母乳喂养、辅食添加等情况进行问卷调查(自行设计),并采用世界卫生组织(WHO)推荐的氰化高铁法测定血红蛋白(hemoglobin,Hb)含量,同时回顾性追踪母亲孕期保健资料,对采集资料进行汇总、统计学处理和分析. 结果 营养性缺铁性贫血总检出率为19.86%(249/1 254), 其中A,B,C组儿童营养性缺铁性贫血检出率分别为26.11%(141/540),19.17%(69/360),11.02%(39/354),随年龄增加,营养性缺铁性贫血发生率下降.单因素分析显示,A组婴儿中,纯母乳喂养儿(n=414)和非纯母乳喂养儿(n=126)缺铁性贫血检出率分别为22.46%(93/414)和38.10%(48/126),两者比较,差异有显著意义(P<0.05).A组纯母乳喂养儿中,及时和过晚添加辅食儿(n=309 vs. n=105)的营养性缺铁性贫血检出率分别为16.50%(51/309),40.00%(42/105),两者比较,差异有显著意义(P<0.01).母亲孕期保健资料回顾性分析结果显示,249例营养性缺铁性贫血婴、幼儿中,孕妇孕晚期缺铁性贫血为78例(31.5%).结论 婴、幼儿饮食结构不合理和母亲孕晚期缺铁性贫血,是导致婴、幼儿营养性缺铁性贫血的重要影响因素.加强围生期保健, 提倡婴儿期母乳喂养的同时注意适时(4~6个月龄时)添加辅食,是减少婴儿期营养性缺铁性贫血的有效措施.

  15. Book review: Garden plots: the politics and poetics of gardens. By Shelley Saguaro. Aldershot, Hants and Burlington, VT: Ashgate Publishing Limited. 2006. xiii + 249 pp. #50.00 hardback. ISBN: 9780754637530

    OpenAIRE

    2008-01-01

    Book review: Garden plots: the politics and poetics of gardens. By Shelley Saguaro. Aldershot, Hants and Burlington, VT: Ashgate Publishing Limited. 2006. xiii + 249 pp. #50.00 hardback. ISBN: 9780754637530 Kingston University - (Preston, Rebecca)

  16. Evidence for association of D1S249 locus on human chromosome 1 with the susceptibility to essential hypertension in Han Chinese

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Essential hypertension (EH) is thought to result from theinteraction of environmental and genetic factors. The molecular genetics of EH has witnessed considerable progress during the past few years. However, the number of genes involved, their chromosomal location and the magnitude of their effect on EH susceptibility are unknown. We conducted the present study to screen susceptibility genes to essential hypertension using a genome-wide scanning method in a group of Han people from Fangshan district located in the southwest of Beijing. A case-control study and affected sibpair were performed. Genotyping was carried out using a fluorescence-based semiautomated technique on automated DNA sequencer (ABI 377, PE). The basis for the genome-screen was the ABI prism linkage mapping sets of 400 microsatellite markers (version 2, PE, Co.). PCR for amplification of markers was carried out as multiplex reactions with Ampli Taq gold (PE, Co.) following protocols developed in our laboratory. Data were exported as a text file from genotyper for subsequent two-point affected sibpair linkage analysis. The data from case-control association study showed a linkage disequilibrium between EH and marker D1S249 locus (X2 = 14.6, P = 0.002). There are 12 alleles in the D1S249 locus. The frequency of A9 allele in hypertension was higher than in normotensives, (13.6% v.s. 2.7%, X2 = 6.30, p = 0.01, OR = 4.57, 95%CI = 1.24-25.4). The data from two-point affected sibpair linkage analysis demonstrated a linkage between EH and A9 allele, P<0.05. It suggested that microsatellite marker D1S249 locus might be associated with the genetic susceptibility to essential hypertension in Han Chinese.

  17. Calculations of the cross sections for synthesis of new {293-296}118 isotopes in {249-252}Cf(48Ca,xn) reactions

    CERN Document Server

    Cap, T; Kowal, M; Wilczynski, J

    2013-01-01

    A project of using a target consisting of the mixture of (249-252)Cf isotopes to be bombarded with the 48Ca beam, aimed to synthesize new isotopes of the heaviest known element Z = 118, is under way at the FLNR in Dubna. In the present work excitation functions for all the reactions: 249Cf(48Ca,xn)(297-x)118, 250Cf(48Ca,xn)(298-x)118, 251Cf(48Ca,xn)(299-x)118 and 252Cf(48Ca,xn)(300-x)118 have been calculated in the framework of the fusion-by-diffusion model, assuming fission barriers, ground-state masses and shell effects of the superheavy nuclei predicted by Kowal et al. Energy dependence of the effective cross sections for the synthesis of selected new isotopes: (293)118, (294)118, (295)118 and (296)118 is predicted for the particular isotopic composition of the Cf target prepared for the Dubna experiment.

  18. Observation of high-j quasiparticle states in Cm249 by in-beam γ-ray spectroscopy using heavy-ion transfer reactions

    Science.gov (United States)

    Ishii, T.; Makii, H.; Asai, M.; Tsukada, K.; Toyoshima, A.; Matsuda, M.; Makishima, A.; Shigematsu, S.; Kaneko, J.; Shizuma, T.; Toume, H.; Hossain, I.; Kohno, T.; Ogawa, M.

    2008-11-01

    We have measured de-excitation γ rays in Cm249 populated by one-neutron stripping reactions with a Cm248 target and 162-MeV O16, 162-MeV O18, and 120-MeV C13 beams. γ rays in Cm249 were identified by measuring kinetic energies of outgoing particles using Si ΔE-E detectors. It was demonstrated that high-j orbitals were selectively populated in the (O16, O15) reaction having a large negative Q value. We have observed eight quasiparticle states above the deformed shell gap of N=152. The 1/2+[620], 1/2-[750], and 7/2+[613] bands were extended up to 19/2+, 19/2-, and 13/2+ states, respectively. We have established the 9/29/2+[615] state at 526 keV, the 9/29/2+[604] state with a short life of T1/2≪2 ps at 1030 keV, and the 11/211/2-[725] state with T1/2=19(1) ns at 375 keV. Furthermore, the 17/21/2+[880] state, having a large component of the k17/2 spherical single-particle state, has been identified at 1505 keV. We discuss the properties of those quasiparticle states in the framework of a deformed shell model.

  19. Observation of high-j quasiparticle states in 249Cm by in-beam γ-ray spectroscopy using heavy-ion transfer reactions

    International Nuclear Information System (INIS)

    We have measured de-excitation γ rays in 249Cm populated by one-neutron stripping reactions with a 248Cm target and 162-MeV 16O, 162-MeV 18O, and 120-MeV 13C beams. γ rays in 249Cm were identified by measuring kinetic energies of outgoing particles using Si ΔE-E detectors. It was demonstrated that high-j orbitals were selectively populated in the (16O, 15O) reaction having a large negative Q value. We have observed eight quasiparticle states above the deformed shell gap of N=152. The 1/2+[620], 1/2-[750], and 7/2+[613] bands were extended up to 19/2+, 19/2-, and 13/2+ states, respectively. We have established the 9/2 9/2+[615] state at 526 keV, the 9/2 9/2+[604] state with a short life of T1/2-[725] state with T1/2=19(1) ns at 375 keV. Furthermore, the 17/2 1/2+[880] state, having a large component of the k17/2 spherical single-particle state, has been identified at 1505 keV. We discuss the properties of those quasiparticle states in the framework of a deformed shell model

  20. A Novel Substitution of The Heme-binding Residue Histidine-245 by Histidine-249 in Heme Oxygenase HugZ%血红素氧合酶HugZ组氨酸-249对组氨酸-245侧链缺失补偿的结构基础

    Institute of Scientific and Technical Information of China (English)

    沈溪辉; 胡永林; 王大成

    2012-01-01

    The heme oxygenase HugZ from Helicobacter pylori plays essential roles in the colonization of the bacteria in human hosts and is required for the utilization of heme as the sole iron source. Residue His245, which is highly conserved, coordinates the heme iron through its sidechain imidazole group. Surprisingly, this residue was not required for the enzymatic activities of HugZ. To investigate the roles played by His245 in heme binding and enzymatic mechanisms of HugZ, we have solved the crystal structure of HugZ mutant H245A at 2.55 (A) resolution and found that a nearby histidine residue, His249, coordinates the heme iron. This substitution is made possible by the fact that both residues 245 and 249 are located in a flexible loop region ranged from Gly239 to the C-terminus. Similar structural features have not been observed in other heme oxygenases so far. We have also performed spectroscopic studies on the heme-binding properties of HugZ and relevant mutants and our results suggest that the flexible C-terminal loop region of HugZ and the presence of multiple histidine residues in this region may play important roles in heme recruiting and in the catalytic mechanisms of HugZ.%血红素氧合酶HugZ是幽门螺旋杆菌(Helicobacter pylori)利用宿主血红素作为铁源的关键蛋白.HugZ的His245残基侧链咪唑基与血红素中心铁配位结合,是酶活中心的重要组成部分.用定点突变的方法构建HugZ突变体H245A、H249A和H245A/H249A基因,并将突变体蛋白表达纯化.通过X射线晶体学途径解析了突变体H245A与血红素复合物的2.55(A)分辨率晶体结构.结构解析表明,HugZ的His249残基侧链咪唑基团与血红素的铁原子结合,从而补偿了His245侧链缺失.这种结构特征在已知血红素氧合酶中未曾发现.Va1238ψ平面的可翻转和Gly239的柔性是His249能与血红素配位结合的关键原因,二者的共同作用改变了C端肽链的走向,使Va1238与His249之间的柔性

  1. Modified model of neutron resonances widths distributions. Results of reduced neutron widths approximation for mass region 35 ≤ A ≤ 249

    International Nuclear Information System (INIS)

    The distributions of the reduced neutron widths of s-, p- and d-resonances of nuclei of any type from nuclear mass region 35 ≤ A ≤ 249 were approximated with maximal precision by the model which presents experimental data set as a superposition of a maximum of four independent neutron amplitudes. Under the assumption that each of these amplitudes has the Gauss distribution with the unique maximum there were determined the most probable values of contribution of each amplitude in summary width distribution, their most probable mean values and dispersions. Comparison of the obtained χ2 values with value χ2 at description of the experimental data by one distribution of neutron amplitudes with best fitted parameters shows that all widths from more than 157 analyzed data sets can have different types of wave functions

  2. Comment on “Human impacts on headwater fluvial systems in the northern and central Andes” (Carol P. Harden, Geomorphology 79, 249 263)

    Science.gov (United States)

    Buytaert, Wouter; De Bièvre, Bert; Celleri, Rolando; Cisneros, Felipe; Wyseure, Guido; Deckers, Seppe

    2008-04-01

    The high altitude grasslands of the tropical Andes, known as páramo, are a very fragile and unique ecosystem. Despite increasing human activities, many of its geomorphological and hydrological processes are still very poorly understood. We therefore welcome the paper of Harden [Harden, C.P., 2006. Human impacts on headwater fluvial systems in the northern and central Andes. Geomorphology 79, 249-263.] about "Human impacts on headwater fluvial systems in the northern and central Andes" as a valuable contribution to a better understanding of this complex ecosystem. However, in view of the available literature, we would like to complement the interpretation of the presented results and discuss some of the claims made in the paper.

  3. Crystal structure of apatite type Ca2.49Nd7.51(SiO4)6O1.75.

    Science.gov (United States)

    Le, Thu Hoai; Brooks, Neil R; Binnemans, Koen; Blanpain, Bart; Guo, Muxing; Van Meervelt, Luc

    2016-02-01

    The title compound, Ca2+x Nd8-x (SiO4)6O2-0.5x (x = 0.49), was synthesized at 1873 K and rapidly quenched to room temperature. Its structure has been determined using single-crystal X-ray diffraction and compared with results reported using neutron and X-ray powder diffraction from samples prepared by slow cooling. The single-crystal structure from room temperature data was found to belong to the space group P63/m and has the composition Ca2.49Nd7.51(SiO4)6O1.75 [dicalcium octa-neodymium hexa-kis-(ortho-silicate) dioxide], being isotypic with natural apatite and the previously reported Ca2Nd8(SiO4)6O2 and Ca2.2Nd7.8(SiO4)6O1.9. The solubility limit of calcium in the equilibrium state at 1873 K was found to occur at a composition of Ca2+x Nd8-x (SiO4)6O2-0.5x , where x = 0.49. PMID:26958389

  4. Crystal structure of apatite type Ca2.49Nd7.51(SiO46O1.75

    Directory of Open Access Journals (Sweden)

    Thu Hoai Le

    2016-02-01

    Full Text Available The title compound, Ca2+xNd8–x(SiO46O2–0.5x (x = 0.49, was synthesized at 1873 K and rapidly quenched to room temperature. Its structure has been determined using single-crystal X-ray diffraction and compared with results reported using neutron and X-ray powder diffraction from samples prepared by slow cooling. The single-crystal structure from room temperature data was found to belong to the space group P63/m and has the composition Ca2.49Nd7.51(SiO46O1.75 [dicalcium octaneodymium hexakis(orthosilicate dioxide], being isotypic with natural apatite and the previously reported Ca2Nd8(SiO46O2 and Ca2.2Nd7.8(SiO46O1.9. The solubility limit of calcium in the equilibrium state at 1873 K was found to occur at a composition of Ca2+xNd8–x(SiO46O2–0.5x, where x = 0.49.

  5. Recoil-range studies of heavy products of multinucleon transfer from /sup 18/O to /sup 245/Cm and /sup 249/Cf

    Energy Technology Data Exchange (ETDEWEB)

    McFarland, R.M.

    1982-09-01

    Recoil range distributions were measured for alpha and spontaneous fission activities made in the bombardment of /sup 245/Cm and /sup 249/Cf with /sup 18/O from 6.20 MeV/nucleon down to the interaction barrier. The shape of the distributions indicates tht transfers of up to four protons take place via a combination of quasi-elastic (QET) and deep inelastic (DIT) mechanisms, rather than complete fusion-de-excitation (CF) or massive transfer (MT). Angular distributions constructed from recoil range distributions, assuming QET/DIT, indicate that the QET component contributes more significantly to the heavy product residue cross section than the DIT, even though primary cross sections are expected to be higher for DIT than for QET. This may be explained qualitatively as a result of the high excitation energies associated with DIT; the very negative Q/sub gg/ of projectile stripping for these systems combined with the lower expected optimal Q/sub rxn/ of QET compared to DIT can give QET products comparatively low excitation.

  6. Platone interprete di se stesso. «Menone» 98a alla luce di «Fedro» 249b-c

    Directory of Open Access Journals (Sweden)

    Lavinia Maggi

    2016-01-01

    Full Text Available La definizione di ἐπιστήμη come ὀρθὴ δόξα legata αἰτίας λογισμῷ, che compare in Menone 98a, presenta notevoli difficoltà interpretative non solo per quanto riguarda l’identificazione dell’αἰτία, ma anche per la possibilità o meno di scorgere sullo sfondo di tale enunciazione la teoria delle Idee (nella versione dei cosiddetti “dialoghi della maturità”. La questione può essere affrontata sia considerando il controverso passo all’interno del contesto più ampio del dialogo (dove compare per la prima volta la teoria dell’ἀνάμνησις, che alla teoria delle Idee è strettamente legata, ma anche in relazione a passi di altri dialoghi platonici, in particolare Fedro 249b-c: qui, dove l’epistemologia platonica si sviluppa secondo la teoria delle Idee, la volontà di Platone di alludere direttamente a Menone 98a sembra offrire una chiave interpretativa anche per quella precedente formulazione. La necessità di leggere ogni dialogo secondo le sue specificità (periodo di composizione, argomento principale, tipologia dei personaggi coinvolti non esclude infatti che, almeno in alcuni casi, Platone stabilisca dei collegamenti che consentano una continuità di lettura nel percorso di sviluppo del suo pensiero.

  7. Characterization of CCR5△32、 CCR2b-64I、 CX3CR1-249I280M and SDF1-3'A Allelic Polymorphisms in the Chinese Uygur Population

    Institute of Scientific and Technical Information of China (English)

    LIU Mingxu(刘明旭); WANG Fusheng(王福生); JIN Lei(金磊); HONG Weiguo(洪卫国); LEI Zhouyun(雷周云); ZHANG Bing(张冰); HOU Jing(候静); ZHANG Zhanping(张战平); TANG Chunjun(唐纯军)

    2002-01-01

    Objectives: Allelic polymorphisms of CCR5△32 、CCR2b-64I,CX3CR1-249I280M and SDF1-3'A associatedwith HIV-1 infection and disease progression wereinvestigated in indigenous Uygur populations from theXinjiang Uygur Autonomous Region of China.Methods: The study population comprised 316 healthyUygur subjects with an age range of 1-80 years old, fromwhom whole peripheral blood samples were collected andnone were HIV-1 seropositive. Genomic DNA samples werepurified using a Qiagen Blood Kit. Genotyping of theaforementioned four alleles was performed using PCR orPCR/RFLP assay, and further confirmed by direct DNAsequencing.Results: The allelic frequencies in Chinese Uygurpopulation were as follows: 3.48% for CCR5△32; 19.45% forCCR2b-64I; 13.8% for CX3CR1-249I280M haplotype, and20.41% for SDF1-3'A. Mutant allele distributions amongUygur populations were in accordance with theHardy-Weinberg equilibrium. No statistical difference wasfound between the frequency of the three HIV coreceptors andtheir respective ligand genes.Conclusion: The frequency of SDF1-3'A andCX3CR1-249I280M haplotypes in these Uygur populationswas similar to that of Caucasian people, while the frequency ofthe CCR2b-64I haplotype more closely matched the HanChinese. The frequency of CCR5△32 in Uygur populationswas between Caucasian and Han frequencies, the more closelymatching the frequency in Medi-Asia people. No geneticlinkage between any two of the three HIV coreceptor geneswas found, but obvious genetic linkages existed betweenCX3CR1-249I and CX3CR1-280M,with even higher linkagedegrees than Caucasian people.

  8. Convergent Evolution of Fern-Specific Mitochondrial Group II Intron atp1i361g2 and Its Ancient Source Paralogue rps3i249g2 and Independent Losses of Intron and RNA Editing among Pteridaceae

    Science.gov (United States)

    Zumkeller, Simon Maria; Knoop, Volker; Knie, Nils

    2016-01-01

    Mitochondrial intron patterns are highly divergent between the major land plant clades. An intron in the atp1 gene, atp1i361g2, is an example for a group II intron specific to monilophytes (ferns). Here, we report that atp1i361g2 is lost independently at least 4 times in the fern family Pteridaceae. Such plant organelle intron losses have previously been found to be accompanied by loss of RNA editing sites in the flanking exon regions as a consequence of genomic recombination of mature cDNA. Instead, we now observe that RNA editing events in both directions of pyrimidine exchange (C-to-U and U-to-C) are retained in atp1 exons after loss of the intron in Pteris argyraea/biaurita and in Actiniopteris and Onychium. We find that atp1i361g2 has significant similarity with intron rps3i249g2 present in lycophytes and gymnosperms, which we now also find highly conserved in ferns. We conclude that atp1i361g2 may have originated from the more ancestral rps3i249g2 paralogue by a reverse splicing copy event early in the evolution of monilophytes. Secondary structure elements of the two introns, most characteristically their domains III, show strikingly convergent evolution in the monilophytes. Moreover, the intron paralogue rps3i249g2 reveals relaxed evolution in taxa where the atp1i361g2 paralogue is lost. Our findings may reflect convergent evolution of the two related mitochondrial introns exerted by co-evolution with an intron-binding protein simultaneously acting on the two paralogues. PMID:27492234

  9. Identification of a novel BRCA1 nucleotide 4803delCC/c.4684delCC mutation and a nucleotide 249T>A/c.130T>A (p.Cys44Ser) mutation in two Greenlandic Inuit families

    DEFF Research Database (Denmark)

    Hansen, Thomas van Overeem; Jønson, Lars; Albrechtsen, Anders;

    2010-01-01

    identified in this population. Here, we describe the identification of a novel disease-causing BRCA1 nucleotide 4803delCC/c.4684delCC mutation in a Greenlandic Inuit with ovarian cancer. The mutation introduces a frameshift and a premature stop at codon 1572. We have also identified a BRCA1 nucleotide 249T...

  10. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015

    DEFF Research Database (Denmark)

    Moesgaard Iburg, Kim

    2016-01-01

    to 2015, gains largely attributable to decreases in mortality rates due to HIV/AIDS (42·1%, 39·1–44·6), malaria (43·1%, 34·7–51·8), neonatal preterm birth complications (29·8%, 24·8–34·9), and maternal disorders (29·1%, 19·3–37·1). Progress was slower for several causes, such as lower respiratory......Summary Background Improving survival and extending the longevity of life for all populations requires timely, robust evidence on local mortality levels and trends. The Global Burden of Disease 2015 Study (GBD 2015) provides a comprehensive assessment of all-cause and cause-specific mortality...... for 249 causes in 195 countries and territories from 1980 to 2015. These results informed an in-depth investigation of observed and expected mortality patterns based on sociodemographic measures. Methods We estimated all-cause mortality by age, sex, geography, and year using an improved analytical...

  11. An experimental investigation of M-subshell fluorescence yields and of the L1-L3 radiative transition in neptunium and curium from the radioactive decays of 241Am and 249Cf

    International Nuclear Information System (INIS)

    The construction and performance of a wall-less multiwire proportional counter (MWPC) is described. The absolute emission rate of M x rays from a 241Am source was measured with the MWPC and with a single-wire proportional counter and a value of (6.35 +- 0.60) x 10-2 M x rays per decay, or (0.470 +- 0.045) M x rays per L/sub α/ x ray is obtained. High resolution Ge(Li) and Si(Li) x-ray spectrometers and the multiwire proportional counter (MWPC) were used for measuring coincidences, respectively, between various L x rays and the M x rays of neptunium (Z = 93) from a 241Am source. In addition, M x rays of curium from a 249Cf source were measured with a Si(Li) detector in coincidence with various K and L x rays detected with a Ge(Li) spectrometer. 81 refs., 24 figs., 23 tabs

  12. Solution of the Skyrme-Hartree-Fock-Bogolyubov equations in the Cartesian deformed harmonic-oscillator basis. (VII) HFODD (v2.49s): a new version of the program

    CERN Document Server

    Schunck, N; McDonnell, J; Satula, W; Sheikh, J A; Staszczak, A; Stoitsov, M; Toivanen, P

    2011-01-01

    We describe the new version (v2.49s) of the code HFODD which solves the nuclear Skyrme Hartree-Fock (HF) or Skyrme Hartree-Fock-Bogolyubov (HFB) problem by using the Cartesian deformed harmonic-oscillator basis. In the new version, we have implemented the following physics features: (i) the isospin mixing and projection, (ii) the finite temperature formalism for the HFB and HF+BCS methods, (iii) the Lipkin translational energy correction method, (iv) the calculation of the shell correction. A number of specific numerical methods have also been implemented in order to deal with large-scale multi-constraint calculations and hardware limitations: (i) the two-basis method for the HFB method, (ii) the Augmented Lagrangian Method (ALM) for multi-constraint calculations, (iii) the linear constraint method based on the approximation of the RPA matrix for multi-constraint calculations, (iv) an interface with the axial and parity-conserving Skyrme-HFB code HFBTHO, (v) the mixing of the HF or HFB matrix elements instead...

  13. Solution of the Skyrme-Hartree-Fock-Bogolyubov equations in the Cartesian deformed harmonic-oscillator basis. (VII) HFODD (v2.49t): A new version of the program

    International Nuclear Information System (INIS)

    We describe the new version (v2.49t) of the code HFODD which solves the nuclear Skyrme Hartree-Fock (HF) or Skyrme Hartree-Fock-Bogolyubov (HFB) problem by using the Cartesian deformed harmonic-oscillator basis. In the new version, we have implemented the following physics features: (i) the isospin mixing and projection, (ii) the finite temperature formalism for the HFB and HF+BCS methods, (iii) the Lipkin translational energy correction method, (iv) the calculation of the shell correction. A number of specific numerical methods have also been implemented in order to deal with large-scale multi-constraint calculations and hardware limitations: (i) the two-basis method for the HFB method, (ii) the Augmented Lagrangian Method (ALM) for multi-constraint calculations, (iii) the linear constraint method based on the approximation of the RPA matrix for multi-constraint calculations, (iv) an interface with the axial and parity-conserving Skyrme-HFB code HFBTHO, (v) the mixing of the HF or HFB matrix elements instead of the HF fields. Special care has been paid to using the code on massively parallel leadership class computers. For this purpose, the following features are now available with this version: (i) the Message Passing Interface (MPI) framework, (ii) scalable input data routines, (iii) multi-threading via OpenMP pragmas, (iv) parallel diagonalization of the HFB matrix in the simplex breaking case using the ScaLAPACK library. Finally, several little significant errors of the previous published version were corrected.

  14. 32 CFR 249.5 - Procedures.

    Science.gov (United States)

    2010-07-01

    ... data that falls outside the exemptions for export to Canada in United States export regulations may not... meeting organization include, but are not limited to, proprietary data, export-controlled data, Privacy...) Unclassified export-controlled DoD technical data may be presented only in sessions where recipients...

  15. 7 CFR 249.6 - Participant eligibility.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SENIOR FARMERS' MARKET NUTRITION PROGRAM (SFMNP) Participant Eligibility... congregate nutrition services are provided, as categorically eligible to receive SFMNP benefits....

  16. 47 CFR 24.249 - Payment issues.

    Science.gov (United States)

    2010-10-01

    ... issues. (a) Timing. On the day that a PCS entity files its prior coordination notice (PCN) in accordance with § 101.103(d) of this chapter, it must file a copy of the PCN with the clearinghouse....

  17. 49 CFR 173.249 - Bromine.

    Science.gov (United States)

    2010-10-01

    ... tank code T22 (see § 172.102 of this subchapter) or specification IM 101 portable tanks conforming with... from nickel-clad or lead-lined steel plate. Nickel cladding or lead lining must be on the inside of...

  18. Solution of the Skyrme-Hartree-Fock-Bogolyubov equations in the Cartesian deformed harmonic-oscillator basis.. (VII) HFODD (v2.49t): A new version of the program

    Science.gov (United States)

    Schunck, N.; Dobaczewski, J.; McDonnell, J.; Satuła, W.; Sheikh, J. A.; Staszczak, A.; Stoitsov, M.; Toivanen, P.

    2012-01-01

    We describe the new version (v2.49t) of the code HFODD which solves the nuclear Skyrme-Hartree-Fock (HF) or Skyrme-Hartree-Fock-Bogolyubov (HFB) problem by using the Cartesian deformed harmonic-oscillator basis. In the new version, we have implemented the following physics features: (i) the isospin mixing and projection, (ii) the finite-temperature formalism for the HFB and HF + BCS methods, (iii) the Lipkin translational energy correction method, (iv) the calculation of the shell correction. A number of specific numerical methods have also been implemented in order to deal with large-scale multi-constraint calculations and hardware limitations: (i) the two-basis method for the HFB method, (ii) the Augmented Lagrangian Method (ALM) for multi-constraint calculations, (iii) the linear constraint method based on the approximation of the RPA matrix for multi-constraint calculations, (iv) an interface with the axial and parity-conserving Skyrme-HFB code HFBTHO, (v) the mixing of the HF or HFB matrix elements instead of the HF fields. Special care has been paid to using the code on massively parallel leadership class computers. For this purpose, the following features are now available with this version: (i) the Message Passing Interface (MPI) framework, (ii) scalable input data routines, (iii) multi-threading via OpenMP pragmas, (iv) parallel diagonalization of the HFB matrix in the simplex-breaking case using the ScaLAPACK library. Finally, several little significant errors of the previous published version were corrected. New version program summaryProgram title:HFODD (v2.49t) Catalogue identifier: ADFL_v3_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADFL_v3_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: GNU General Public Licence v3 No. of lines in distributed program, including test data, etc.: 190 614 No. of bytes in distributed program, including test data, etc.: 985 898 Distribution

  19. Identification of a novel BRCA1 nucleotide 4803delCC/c.4684delCC mutation and a nucleotide 249T>A/c.130T>A (p.Cys44Ser) mutation in two Greenlandic Inuit families: implications for genetic screening of Greenlandic Inuit families with high risk for breast and/or ovarian cancer

    DEFF Research Database (Denmark)

    Hansen, Thomas V O; Jønson, Lars; Albrechtsen, Anders;

    2010-01-01

    >A/c.130T>A (p.Cys44Ser) mutation in another Greenlandic individual with ovarian cancer. This patient share a 1-2 Mb genomic fragment, containing the BRCA1 gene, with four Danish families harbouring the same mutation, suggesting that the 249T>A/c.130T>A (p.Cys44Ser) mutation originates from a Danish......Germ-line mutations in the tumour suppressor proteins BRCA1 and BRCA2 predispose to breast and ovarian cancer. We have recently identified a Greenlandic Inuit BRCA1 nucleotide 234T>G/c.115T>G (p.Cys39Gly) founder mutation, which at that time was the only disease-causing BRCA1/BRCA2 mutation...... identified in this population. Here, we describe the identification of a novel disease-causing BRCA1 nucleotide 4803delCC/c.4684delCC mutation in a Greenlandic Inuit with ovarian cancer. The mutation introduces a frameshift and a premature stop at codon 1572. We have also identified a BRCA1 nucleotide 249T...

  20. 25 CFR 700.249 - Action on appeals.

    Science.gov (United States)

    2010-04-01

    ... (excepting Saturdays, Sundays, and public legal holidays) after receipt of the appeal. (c) Extensions of time... provisions of § 700.245 or was extended for fewer than ten (10) working days, the time for processing of the... request of more than ten (10) working days. The time for processing of an appeal may be extended only...

  1. 7 CFR 2.49 - Administrator, Rural Housing Service.

    Science.gov (United States)

    2010-01-01

    ... joint regulations issued pursuant thereto by the Attorney General and the Comptroller General (4 CFR... Executive Order 12580, 3 CFR, 1987 Comp., p. 193, under the following provisions of the Comprehensive... section 1-601 of Executive Order 12088, 3 CFR, 1978 Comp., p. 243, to enter into an inter-agency...

  2. Dicty_cDB: AHB249 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available haliana DNA chromoso... 130 4e-40 AK227321_1( AK227321 |pid:none) Arabidopsis thaliana mRNA for hypo... 130 ...4e-40 AK221976_1( AK221976 |pid:none) Arabidopsis thaliana mRNA for hypo... 130 4e-40 AK230210_1( AK230210 |...pid:none) Arabidopsis thaliana mRNA for hypo... 130 7e-40 AK101151_1( AK101151 |p

  3. 7 CFR 249.24 - Data safeguarding procedures.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SENIOR FARMERS' MARKET NUTRITION PROGRAM (SFMNP) Miscellaneous Provisions... authority) that administer food, nutrition, or other assistance programs that serve persons...

  4. Dicty_cDB: SHJ249 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available |AX251183.1 Sequence 151 from Patent WO0168912. 50 2e-05 3 BD452704 |BD452704.1 Diagnosis of Diseases... |BD460593.1 Diagnosis of Diseases Associated with Cell Cycle. 36 0.011 4 dna upd

  5. 40 CFR 180.249 - Alachlor; tolerances for residues.

    Science.gov (United States)

    2010-07-01

    ..., dry 0.1 Beans, succulent lima 0.1 Cattle, fat 0.02 Cattle, meat byproducts 0.02 Cattle, meat 0.02 Corn... 0.02 Horse, meat 0.02 Milk 0.02 Peanut 0.5 Poultry, fat 0.02 Poultry, meat byproducts 0.02...

  6. 7 CFR 249.17 - Management evaluations and reviews.

    Science.gov (United States)

    2010-01-01

    ....17 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SENIOR FARMERS' MARKET NUTRITION PROGRAM (SFMNP... SFMNP and the WIC Farmers' Market Nutrition Program are in operation, these reviews may be...

  7. 7 CFR 249.11 - Financial management system.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SENIOR FARMERS' MARKET NUTRITION PROGRAM (SFMNP) State Agency Provisions... its cash draws against its Letter of Credit in accordance with 31 CFR part 205....

  8. 48 CFR 249.501-70 - Special termination costs.

    Science.gov (United States)

    2010-10-01

    ... of $100 million; and (3) Adequate funds are available to cover the contingent reserve liability for... associated with contingent special termination costs is expected to fluctuate extensively over the period...

  9. Dicty_cDB: SFF249 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 67E10.y2 949 - Juvenile leaf and shoot cDNA from Steve Moose Zea mays cDNA, mRNA sequence. 42 5e-13 4 CA2696... mRNA sequence. 42 1e-12 4 BI478599 |BI478599.1 949067E10.x1 949 - Juvenile leaf and shoot cDNA from Steve M

  10. Use of trioctylphosphine oxide for transplutonium element extraction and purification

    International Nuclear Information System (INIS)

    Investigated was extraction of tri-valent curium, berkelium, californium, einsteinium as well as cerium and europium with trioctylphosphin oxide from lactic acid solutions, containing DTPA and aluminium nitrate depending on the aluminium nitrate and TOPO concentrations and nitric acid solutions of variable concentration as well. Under optimum conditions of extraction chromatography of berkelium studied was the distribution of cobalt, nickel, chromium, iron, aluminium, titanium, zirconium and niobium ions, and the coefficients of berkelium purification from cations investigated were determined. The effect of weight quantities of cation impurities on extraction chromatographic yield of berkelium has been investigated. Examples of practice application of the extraction chromatography with the use of TOPO are given

  11. Extraction studies of selected actinide ions from aqueous solutions with 4-benzoyl-2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-thione and tri-n-octylphosphine oxide

    Energy Technology Data Exchange (ETDEWEB)

    Hannink, N.J.; Hoffman, D.C. [Lawrence Berkeley Lab., CA (United States)]|[California Univ., Berkeley, CA (United States). Dept. of Chemistry; Smith, B.F. [Los Alamos National Lab., NM (United States)

    1991-11-01

    The first measurements of distribution coefficients (K{sub d}) for Cm(III), Bk(III), Cf(III), Es(III), and Fm(III) between aqueous perchlorate solutions and solutions of 4-benzoyl-2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-thione (BMPPT) and the synergist tri-n-octylphosphine oxide (TOPO) in toluene are reported. Curium-243, berkelium-250, californium-249, einsteinium-254, and fermium-253 were used in these studies. The K{sub d} for {sup 241}Am was also measured and is in agreement with previously published results. Our new results show that the K{sub d}`s decrease gradually with increasing atomic number for the actinides with a dip at Cf. In general, the K{sub d}`s for these actinides are about a factor of 5 to 10 greater than the K{sub d}`s for the homologous lanthanides at a pH of 2.9, a BMPPT concentration of 0.2 M, and a TOPO concentration of 0.04 M. The larger K{sub d}`s for the actinides are consistent with greater covalent bonding between the actinide metal ion and the sulfur bonding site in the ligand.

  12. Extraction studies of selected actinide ions from aqueous solutions with 4-benzoyl-2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-thione and tri-n-octylphosphine oxide

    Energy Technology Data Exchange (ETDEWEB)

    Hannink, N.J.; Hoffman, D.C. (Lawrence Berkeley Lab., CA (United States) California Univ., Berkeley, CA (United States). Dept. of Chemistry); Smith, B.F. (Los Alamos National Lab., NM (United States))

    1991-11-01

    The first measurements of distribution coefficients (K{sub d}) for Cm(III), Bk(III), Cf(III), Es(III), and Fm(III) between aqueous perchlorate solutions and solutions of 4-benzoyl-2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-thione (BMPPT) and the synergist tri-n-octylphosphine oxide (TOPO) in toluene are reported. Curium-243, berkelium-250, californium-249, einsteinium-254, and fermium-253 were used in these studies. The K{sub d} for {sup 241}Am was also measured and is in agreement with previously published results. Our new results show that the K{sub d}'s decrease gradually with increasing atomic number for the actinides with a dip at Cf. In general, the K{sub d}'s for these actinides are about a factor of 5 to 10 greater than the K{sub d}'s for the homologous lanthanides at a pH of 2.9, a BMPPT concentration of 0.2 M, and a TOPO concentration of 0.04 M. The larger K{sub d}'s for the actinides are consistent with greater covalent bonding between the actinide metal ion and the sulfur bonding site in the ligand.

  13. Extraction studies of selected actinide ions from aqueous solutions with 4-benzoyl-2,4-Dihydro-5-methyl-2-phenyl-3H-pyrazol-3-thione and Tri-n-octylphosphine oxide

    Energy Technology Data Exchange (ETDEWEB)

    Hannink, N.J.; Hoffman, D.C. [Lawrence Berkeley Lab., CA (United States); Smith, B.F. [Los Alamos National Lab., NM (United States)

    1992-07-01

    The first measurements of distribution coefficients (k{sub d}) for Cm(III), Bk(III), Cf(III), Es(III), and Fm(III) between aqueous perchlorate solutions and solutions of 4-benzoyl-2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-thione (BMPPT) and the synergist tri-n-octylphosphine oxide (TOPO) in toluene are reported. Curium-243, berkelium-250, californium-249, einsteinium-254, and fermium-253 were used in these studies. The K{sub d} for {sup 241}Am was also measured and is in agreement with previously published results. Our new results show that the K{sub d}`s decrease gradually with increasing atomic number for the actinides with a dip at Cf. In general, the K{sub d}`s for these actinides are about about a factor of 10 greater than the K{sub d}`s for the homologous lanthanides at a pH of 2.9, a BMPPT concentration of 0.2 M, and a TOPO concentration of 0.04 M. The larger K{sub d}`s for the actinides are consistent with greater covalent bonding between the actinide metal ion and the sulfur bonding site in the ligand. 9 refs., 2 figs., 1 tab.

  14. Association analyses of 249,796 individuals reveal eighteen new loci associated with body mass index

    Science.gov (United States)

    Speliotes, Elizabeth K.; Willer, Cristen J.; Berndt, Sonja I.; Monda, Keri L.; Thorleifsson, Gudmar; Jackson, Anne U.; Allen, Hana Lango; Lindgren, Cecilia M.; Luan, Jian’an; Mägi, Reedik; Randall, Joshua C.; Vedantam, Sailaja; Winkler, Thomas W.; Qi, Lu; Workalemahu, Tsegaselassie; Heid, Iris M.; Steinthorsdottir, Valgerdur; Stringham, Heather M.; Weedon, Michael N.; Wheeler, Eleanor; Wood, Andrew R.; Ferreira, Teresa; Weyant, Robert J.; Segré, Ayellet V.; Estrada, Karol; Liang, Liming; Nemesh, James; Park, Ju-Hyun; Gustafsson, Stefan; Kilpeläinen, Tuomas O.; Yang, Jian; Bouatia-Naji, Nabila; Esko, Tõnu; Feitosa, Mary F.; Kutalik, Zoltán; Mangino, Massimo; Raychaudhuri, Soumya; Scherag, Andre; Smith, Albert Vernon; Welch, Ryan; Zhao, Jing Hua; Aben, Katja K.; Absher, Devin M.; Amin, Najaf; Dixon, Anna L.; Fisher, Eva; Glazer, Nicole L.; Goddard, Michael E.; Heard-Costa, Nancy L.; Hoesel, Volker; Hottenga, Jouke-Jan; Johansson, Åsa; Johnson, Toby; Ketkar, Shamika; Lamina, Claudia; Li, Shengxu; Moffatt, Miriam F.; Myers, Richard H.; Narisu, Narisu; Perry, John R.B.; Peters, Marjolein J.; Preuss, Michael; Ripatti, Samuli; Rivadeneira, Fernando; Sandholt, Camilla; Scott, Laura J.; Timpson, Nicholas J.; Tyrer, Jonathan P.; van Wingerden, Sophie; Watanabe, Richard M.; White, Charles C.; Wiklund, Fredrik; Barlassina, Christina; Chasman, Daniel I.; Cooper, Matthew N.; Jansson, John-Olov; Lawrence, Robert W.; Pellikka, Niina; Prokopenko, Inga; Shi, Jianxin; Thiering, Elisabeth; Alavere, Helene; Alibrandi, Maria T. S.; Almgren, Peter; Arnold, Alice M.; Aspelund, Thor; Atwood, Larry D.; Balkau, Beverley; Balmforth, Anthony J.; Bennett, Amanda J.; Ben-Shlomo, Yoav; Bergman, Richard N.; Bergmann, Sven; Biebermann, Heike; Blakemore, Alexandra I.F.; Boes, Tanja; Bonnycastle, Lori L.; Bornstein, Stefan R.; Brown, Morris J.; Buchanan, Thomas A.; Busonero, Fabio; Campbell, Harry; Cappuccio, Francesco P.; Cavalcanti-Proença, Christine; Chen, Yii-Der Ida; Chen, Chih-Mei; Chines, Peter S.; Clarke, Robert; Coin, Lachlan; Connell, John; Day, Ian N.M.; den Heijer, Martin; Duan, Jubao; Ebrahim, Shah; Elliott, Paul; Elosua, Roberto; Eiriksdottir, Gudny; Erdos, Michael R.; Eriksson, Johan G.; Facheris, Maurizio F.; Felix, Stephan B.; Fischer-Posovszky, Pamela; Folsom, Aaron R.; Friedrich, Nele; Freimer, Nelson B.; Fu, Mao; Gaget, Stefan; Gejman, Pablo V.; Geus, Eco J.C.; Gieger, Christian; Gjesing, Anette P.; Goel, Anuj; Goyette, Philippe; Grallert, Harald; Gräßler, Jürgen; Greenawalt, Danielle M.; Groves, Christopher J.; Gudnason, Vilmundur; Guiducci, Candace; Hartikainen, Anna-Liisa; Hassanali, Neelam; Hall, Alistair S.; Havulinna, Aki S.; Hayward, Caroline; Heath, Andrew C.; Hengstenberg, Christian; Hicks, Andrew A.; Hinney, Anke; Hofman, Albert; Homuth, Georg; Hui, Jennie; Igl, Wilmar; Iribarren, Carlos; Isomaa, Bo; Jacobs, Kevin B.; Jarick, Ivonne; Jewell, Elizabeth; John, Ulrich; Jørgensen, Torben; Jousilahti, Pekka; Jula, Antti; Kaakinen, Marika; Kajantie, Eero; Kaplan, Lee M.; Kathiresan, Sekar; Kettunen, Johannes; Kinnunen, Leena; Knowles, Joshua W.; Kolcic, Ivana; König, Inke R.; Koskinen, Seppo; Kovacs, Peter; Kuusisto, Johanna; Kraft, Peter; Kvaløy, Kirsti; Laitinen, Jaana; Lantieri, Olivier; Lanzani, Chiara; Launer, Lenore J.; Lecoeur, Cecile; Lehtimäki, Terho; Lettre, Guillaume; Liu, Jianjun; Lokki, Marja-Liisa; Lorentzon, Mattias; Luben, Robert N.; Ludwig, Barbara; Manunta, Paolo; Marek, Diana; Marre, Michel; Martin, Nicholas G.; McArdle, Wendy L.; McCarthy, Anne; McKnight, Barbara; Meitinger, Thomas; Melander, Olle; Meyre, David; Midthjell, Kristian; Montgomery, Grant W.; Morken, Mario A.; Morris, Andrew P.; Mulic, Rosanda; Ngwa, Julius S.; Nelis, Mari; Neville, Matt J.; Nyholt, Dale R.; O’Donnell, Christopher J.; O’Rahilly, Stephen; Ong, Ken K.; Oostra, Ben; Paré, Guillaume; Parker, Alex N.; Perola, Markus; Pichler, Irene; Pietiläinen, Kirsi H.; Platou, Carl G.P.; Polasek, Ozren; Pouta, Anneli; Rafelt, Suzanne; Raitakari, Olli; Rayner, Nigel W.; Ridderstråle, Martin; Rief, Winfried; Ruokonen, Aimo; Robertson, Neil R.; Rzehak, Peter; Salomaa, Veikko; Sanders, Alan R.; Sandhu, Manjinder S.; Sanna, Serena; Saramies, Jouko; Savolainen, Markku J.; Scherag, Susann; Schipf, Sabine; Schreiber, Stefan; Schunkert, Heribert; Silander, Kaisa; Sinisalo, Juha; Siscovick, David S.; Smit, Jan H.; Soranzo, Nicole; Sovio, Ulla; Stephens, Jonathan; Surakka, Ida; Swift, Amy J.; Tammesoo, Mari-Liis; Tardif, Jean-Claude; Teder-Laving, Maris; Teslovich, Tanya M.; Thompson, John R.; Thomson, Brian; Tönjes, Anke; Tuomi, Tiinamaija; van Meurs, Joyce B.J.; van Ommen, Gert-Jan; Vatin, Vincent; Viikari, Jorma; Visvikis-Siest, Sophie; Vitart, Veronique; Vogel, Carla I. G.; Voight, Benjamin F.; Waite, Lindsay L.; Wallaschofski, Henri; Walters, G. Bragi; Widen, Elisabeth; Wiegand, Susanna; Wild, Sarah H.; Willemsen, Gonneke; Witte, Daniel R.; Witteman, Jacqueline C.; Xu, Jianfeng; Zhang, Qunyuan; Zgaga, Lina; Ziegler, Andreas; Zitting, Paavo; Beilby, John P.; Farooqi, I. Sadaf; Hebebrand, Johannes; Huikuri, Heikki V.; James, Alan L.; Kähönen, Mika; Levinson, Douglas F.; Macciardi, Fabio; Nieminen, Markku S.; Ohlsson, Claes; Palmer, Lyle J.; Ridker, Paul M.; Stumvoll, Michael; Beckmann, Jacques S.; Boeing, Heiner; Boerwinkle, Eric; Boomsma, Dorret I.; Caulfield, Mark J.; Chanock, Stephen J.; Collins, Francis S.; Cupples, L. Adrienne; Smith, George Davey; Erdmann, Jeanette; Froguel, Philippe; Grönberg, Henrik; Gyllensten, Ulf; Hall, Per; Hansen, Torben; Harris, Tamara B.; Hattersley, Andrew T.; Hayes, Richard B.; Heinrich, Joachim; Hu, Frank B.; Hveem, Kristian; Illig, Thomas; Jarvelin, Marjo-Riitta; Kaprio, Jaakko; Karpe, Fredrik; Khaw, Kay-Tee; Kiemeney, Lambertus A.; Krude, Heiko; Laakso, Markku; Lawlor, Debbie A.; Metspalu, Andres; Munroe, Patricia B.; Ouwehand, Willem H.; Pedersen, Oluf; Penninx, Brenda W.; Peters, Annette; Pramstaller, Peter P.; Quertermous, Thomas; Reinehr, Thomas; Rissanen, Aila; Rudan, Igor; Samani, Nilesh J.; Schwarz, Peter E.H.; Shuldiner, Alan R.; Spector, Timothy D.; Tuomilehto, Jaakko; Uda, Manuela; Uitterlinden, André; Valle, Timo T.; Wabitsch, Martin; Waeber, Gérard; Wareham, Nicholas J.; Watkins, Hugh; Wilson, James F.; Wright, Alan F.; Zillikens, M. Carola; Chatterjee, Nilanjan; McCarroll, Steven A.; Purcell, Shaun; Schadt, Eric E.; Visscher, Peter M.; Assimes, Themistocles L.; Borecki, Ingrid B.; Deloukas, Panos; Fox, Caroline S.; Groop, Leif C.; Haritunians, Talin; Hunter, David J.; Kaplan, Robert C.; Mohlke, Karen L.; O’Connell, Jeffrey R.; Peltonen, Leena; Schlessinger, David; Strachan, David P.; van Duijn, Cornelia M.; Wichmann, H.-Erich; Frayling, Timothy M.; Thorsteinsdottir, Unnur; Abecasis, Gonçalo R.; Barroso, Inês; Boehnke, Michael; Stefansson, Kari; North, Kari E.; McCarthy, Mark I.; Hirschhorn, Joel N.; Ingelsson, Erik; Loos, Ruth J.F.

    2010-01-01

    Obesity is globally prevalent and highly heritable, but the underlying genetic factors remain largely elusive. To identify genetic loci for obesity-susceptibility, we examined associations between body mass index (BMI) and ~2.8 million SNPs in up to 123,865 individuals, with targeted follow-up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity-susceptibility loci and identified 18 new loci associated with BMI (P<5×10−8), one of which includes a copy number variant near GPRC5B. Some loci (MC4R, POMC, SH2B1, BDNF) map near key hypothalamic regulators of energy balance, and one is near GIPR, an incretin receptor. Furthermore, genes in other newly-associated loci may provide novel insights into human body weight regulation. PMID:20935630

  15. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

    Science.gov (United States)

    Speliotes, Elizabeth K; Willer, Cristen J; Berndt, Sonja I; Monda, Keri L; Thorleifsson, Gudmar; Jackson, Anne U; Lango Allen, Hana; Lindgren, Cecilia M; Luan, Jian'an; Mägi, Reedik; Randall, Joshua C; Vedantam, Sailaja; Winkler, Thomas W; Qi, Lu; Workalemahu, Tsegaselassie; Heid, Iris M; Steinthorsdottir, Valgerdur; Stringham, Heather M; Weedon, Michael N; Wheeler, Eleanor; Wood, Andrew R; Ferreira, Teresa; Weyant, Robert J; Segrè, Ayellet V; Estrada, Karol; Liang, Liming; Nemesh, James; Park, Ju-Hyun; Gustafsson, Stefan; Kilpeläinen, Tuomas O; Yang, Jian; Bouatia-Naji, Nabila; Esko, Tõnu; Feitosa, Mary F; Kutalik, Zoltán; Mangino, Massimo; Raychaudhuri, Soumya; Scherag, Andre; Smith, Albert Vernon; Welch, Ryan; Zhao, Jing Hua; Aben, Katja K; Absher, Devin M; Amin, Najaf; Dixon, Anna L; Fisher, Eva; Glazer, Nicole L; Goddard, Michael E; Heard-Costa, Nancy L; Hoesel, Volker; Hottenga, Jouke-Jan; Johansson, Asa; Johnson, Toby; Ketkar, Shamika; Lamina, Claudia; Li, Shengxu; Moffatt, Miriam F; Myers, Richard H; Narisu, Narisu; Perry, John R B; Peters, Marjolein J; Preuss, Michael; Ripatti, Samuli; Rivadeneira, Fernando; Sandholt, Camilla; Scott, Laura J; Timpson, Nicholas J; Tyrer, Jonathan P; van Wingerden, Sophie; Watanabe, Richard M; White, Charles C; Wiklund, Fredrik; Barlassina, Christina; Chasman, Daniel I; Cooper, Matthew N; Jansson, John-Olov; Lawrence, Robert W; Pellikka, Niina; Prokopenko, Inga; Shi, Jianxin; Thiering, Elisabeth; Alavere, Helene; Alibrandi, Maria T S; Almgren, Peter; Arnold, Alice M; Aspelund, Thor; Atwood, Larry D; Balkau, Beverley; Balmforth, Anthony J; Bennett, Amanda J; Ben-Shlomo, Yoav; Bergman, Richard N; Bergmann, Sven; Biebermann, Heike; Blakemore, Alexandra I F; Boes, Tanja; Bonnycastle, Lori L; Bornstein, Stefan R; Brown, Morris J; Buchanan, Thomas A; Busonero, Fabio; Campbell, Harry; Cappuccio, Francesco P; Cavalcanti-Proença, Christine; Chen, Yii-Der Ida; Chen, Chih-Mei; Chines, Peter S; Clarke, Robert; Coin, Lachlan; Connell, John; Day, Ian N M; den Heijer, Martin; Duan, Jubao; Ebrahim, Shah; Elliott, Paul; Elosua, Roberto; Eiriksdottir, Gudny; Erdos, Michael R; Eriksson, Johan G; Facheris, Maurizio F; Felix, Stephan B; Fischer-Posovszky, Pamela; Folsom, Aaron R; Friedrich, Nele; Freimer, Nelson B; Fu, Mao; Gaget, Stefan; Gejman, Pablo V; Geus, Eco J C; Gieger, Christian; Gjesing, Anette P; Goel, Anuj; Goyette, Philippe; Grallert, Harald; Grässler, Jürgen; Greenawalt, Danielle M; Groves, Christopher J; Gudnason, Vilmundur; Guiducci, Candace; Hartikainen, Anna-Liisa; Hassanali, Neelam; Hall, Alistair S; Havulinna, Aki S; Hayward, Caroline; Heath, Andrew C; Hengstenberg, Christian; Hicks, Andrew A; Hinney, Anke; Hofman, Albert; Homuth, Georg; Hui, Jennie; Igl, Wilmar; Iribarren, Carlos; Isomaa, Bo; Jacobs, Kevin B; Jarick, Ivonne; Jewell, Elizabeth; John, Ulrich; Jørgensen, Torben; Jousilahti, Pekka; Jula, Antti; Kaakinen, Marika; Kajantie, Eero; Kaplan, Lee M; Kathiresan, Sekar; Kettunen, Johannes; Kinnunen, Leena; Knowles, Joshua W; Kolcic, Ivana; König, Inke R; Koskinen, Seppo; Kovacs, Peter; Kuusisto, Johanna; Kraft, Peter; Kvaløy, Kirsti; Laitinen, Jaana; Lantieri, Olivier; Lanzani, Chiara; Launer, Lenore J; Lecoeur, Cecile; Lehtimäki, Terho; Lettre, Guillaume; Liu, Jianjun; Lokki, Marja-Liisa; Lorentzon, Mattias; Luben, Robert N; Ludwig, Barbara; Manunta, Paolo; Marek, Diana; Marre, Michel; Martin, Nicholas G; McArdle, Wendy L; McCarthy, Anne; McKnight, Barbara; Meitinger, Thomas; Melander, Olle; Meyre, David; Midthjell, Kristian; Montgomery, Grant W; Morken, Mario A; Morris, Andrew P; Mulic, Rosanda; Ngwa, Julius S; Nelis, Mari; Neville, Matt J; Nyholt, Dale R; O'Donnell, Christopher J; O'Rahilly, Stephen; Ong, Ken K; Oostra, Ben; Paré, Guillaume; Parker, Alex N; Perola, Markus; Pichler, Irene; Pietiläinen, Kirsi H; Platou, Carl G P; Polasek, Ozren; Pouta, Anneli; Rafelt, Suzanne; Raitakari, Olli; Rayner, Nigel W; Ridderstråle, Martin; Rief, Winfried; Ruokonen, Aimo; Robertson, Neil R; Rzehak, Peter; Salomaa, Veikko; Sanders, Alan R; Sandhu, Manjinder S; Sanna, Serena; Saramies, Jouko; Savolainen, Markku J; Scherag, Susann; Schipf, Sabine; Schreiber, Stefan; Schunkert, Heribert; Silander, Kaisa; Sinisalo, Juha; Siscovick, David S; Smit, Jan H; Soranzo, Nicole; Sovio, Ulla; Stephens, Jonathan; Surakka, Ida; Swift, Amy J; Tammesoo, Mari-Liis; Tardif, Jean-Claude; Teder-Laving, Maris; Teslovich, Tanya M; Thompson, John R; Thomson, Brian; Tönjes, Anke; Tuomi, Tiinamaija; van Meurs, Joyce B J; van Ommen, Gert-Jan; Vatin, Vincent; Viikari, Jorma; Visvikis-Siest, Sophie

    2010-11-01

    Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ∼ 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10⁻⁸), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.

  16. Preserved urethral plate urethroplasty for failed hypospadias repair: report of 249 cases

    Institute of Scientific and Technical Information of China (English)

    ZHANG Wei-ping; TIAN Jun; LI Ming-lei; SONG Hong-cheng; BAI Ji-wu; HUANG Cheng-ru; SUN Ning

    2008-01-01

    @@ Hypospadias is one of the most common abnormalities of the external male genitalia but is very difficult to repair. Hypospadias reoperation is also a common practice for pediatric urologists, though repair of hypospadias at reoperation is much more difficult.

  17. Foreign Investment in the U.S.: Costs and Benefits. Headline Series 249.

    Science.gov (United States)

    Zupnick, Elliot

    The document discusses the implications and positive and negative aspects of foreign direct investment in the United States. The objective is to determine whether a restrictive U.S. policy as it relates to foreign direct investment in the United States is desirable. It is presented in five chapters. Chapter I defines foreign direct investment…

  18. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

    DEFF Research Database (Denmark)

    Speliotes, Elizabeth K; Willer, Cristen J; Berndt, Sonja I;

    2010-01-01

    Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ~ 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SN...

  19. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

    NARCIS (Netherlands)

    Speliotes, Elizabeth K.; Willer, Cristen J.; Berndt, Sonja I.; Monda, Keri L.; Thorleifsson, Gudmar; Jackson, Anne U.; Allen, Hana Lango; Lindgren, Cecilia M.; Luan, Jian'an; Maegi, Reedik; Randall, Joshua C.; Vedantam, Sailaja; Winkler, Thomas W.; Qi, Lu; Workalemahu, Tsegaselassie; Heid, Iris M.; Steinthorsdottir, Valgerdur; Stringham, Heather M.; Weedon, Michael N.; Wheeler, Eleanor; Wood, Andrew R.; Ferreira, Teresa; Weyant, Robert J.; Segre, Ayellet V.; Estrada, Karol; Liang, Liming; Nemesh, James; Park, Ju-Hyun; Gustafsson, Stefan; Kilpelaenen, Tuomas O.; Yang, Jian; Bouatia-Naji, Nabila; Esko, Tonu; Feitosa, Mary F.; Kutalik, Zoltan; Mangino, Massimo; Raychaudhuri, Soumya; Scherag, Andre; Smith, Albert Vernon; Welch, Ryan; Zhao, Jing Hua; Aben, Katja K.; Absher, Devin M.; Amin, Najaf; Dixon, Anna L.; Fisher, Eva; Glazer, Nicole L.; Goddard, Michael E.; Heard-Costa, Nancy L.; Hoesel, Volker; Hottenga, Jouke-Jan; Johansson, Asa; Johnson, Toby; Ketkar, Shamika; Lamina, Claudia; Li, Shengxu; Moffatt, Miriam F.; Myers, Richard H.; Narisu, Narisu; Perry, John R. B.; Peters, Marjolein J.; Preuss, Michael; Ripatti, Samuli; Rivadeneira, Fernando; Sandholt, Camilla; Scott, Laura J.; Timpson, Nicholas J.; Tyrer, Jonathan P.; van Wingerden, Sophie; Watanabe, Richard M.; White, Charles C.; Wiklund, Fredrik; Barlassina, Christina; Chasman, Daniel I.; Cooper, Matthew N.; Jansson, John-Olov; Lawrence, Robert W.; Pellikka, Niina; Prokopenko, Inga; Shi, Jianxin; Thiering, Elisabeth; Alavere, Helene; Alibrandi, Maria T. S.; Almgren, Peter; Arnold, Alice M.; Aspelund, Thor; Atwood, Larry D.; Balkau, Beverley; Balmforth, Anthony J.; Bennett, Amanda J.; Ben-Shlomo, Yoav; Bergman, Richard N.; Bergmann, Sven; Biebermann, Heike; Blakemore, Alexandra I. F.; Boes, Tanja; Bonnycastle, Lori L.; Bornstein, Stefan R.; Brown, Morris J.; Buchanan, Thomas A.; Busonero, Fabio; Campbell, Harry; Cappuccio, Francesco P.; Cavalcanti-Proenca, Christine; Chen, Yii-Der Ida; Chen, Chih-Mei; Chines, Peter S.; Clarke, Robert; Coin, Lachlan; Connell, John; Day, Ian N. M.; den Heijer, Martin; Duan, Jubao; Ebrahim, Shah; Elliott, Paul; Elosua, Roberto; Eiriksdottir, Gudny; Erdos, Michael R.; Eriksson, Johan G.; Facheris, Maurizio F.; Felix, Stephan B.; Fischer-Posovszky, Pamela; Folsom, Aaron R.; Friedrich, Nele; Freimer, Nelson B.; Fu, Mao; Gaget, Stefan; Gejman, Pablo V.; Geus, Eco J. C.; Gieger, Christian; Gjesing, Anette P.; Goel, Anuj; Goyette, Philippe; Grallert, Harald; Graessler, Juergen; Greenawalt, Danielle M.; Groves, Christopher J.; Gudnason, Vilmundur; Guiducci, Candace; Hartikainen, Anna-Liisa; Hassanali, Neelam; Hall, Alistair S.; Havulinna, Aki S.; Hayward, Caroline; Heath, Andrew C.; Hengstenberg, Christian; Hicks, Andrew A.; Hinney, Anke; Hofman, Albert; Homuth, Georg; Hui, Jennie; Igl, Wilmar; Iribarren, Carlos; Isomaa, Bo; Jacobs, Kevin B.; Jarick, Ivonne; Jewell, Elizabeth; John, Ulrich; Jorgensen, Torben; Jousilahti, Pekka; Jula, Antti; Kaakinen, Marika; Kajantie, Eero; Kaplan, Lee M.; Kathiresan, Sekar; Kettunen, Johannes; Kinnunen, Leena; Knowles, Joshua W.; Kolcic, Ivana; Koenig, Inke R.; Koskinen, Seppo; Kovacs, Peter; Kuusisto, Johanna; Kraft, Peter; Kvaloy, Kirsti; Laitinen, Jaana; Lantieri, Olivier; Lanzani, Chiara; Launer, Lenore J.; Lecoeur, Cecile; Lehtimaeki, Terho; Lettre, Guillaume; Liu, Jianjun; Lokki, Marja-Liisa; Lorentzon, Mattias; Luben, Robert N.; Ludwig, Barbara; Manunta, Paolo; Marek, Diana; Marre, Michel; Martin, Nicholas G.; McArdle, Wendy L.; McCarthy, Anne; McKnight, Barbara; Meitinger, Thomas; Melander, Olle; Meyre, David; Midthjell, Kristian; Montgomery, Grant W.; Morken, Mario A.; Morris, Andrew P.; Mulic, Rosanda; Ngwa, Julius S.; Nelis, Mari; Neville, Matt J.; Nyholt, Dale R.; O'Donnell, Christopher J.; O'Rahilly, Stephen; Ong, Ken K.; Oostra, Ben; Pare, Guillaume; Parker, Alex N.; Perola, Markus; Pichler, Irene; Pietilaeinen, Kirsi H.; Platou, Carl G. P.; Polasek, Ozren; Pouta, Anneli; Rafelt, Suzanne; Raitakari, Olli; Rayner, Nigel W.; Ridderstrale, Martin; Rief, Winfried; Ruokonen, Aimo; Robertson, Neil R.; Rzehak, Peter; Salomaa, Veikko; Sanders, Alan R.; Sandhu, Manjinder S.; Sanna, Serena; Saramies, Jouko; Savolainen, Markku J.; Scherag, Susann; Schipf, Sabine; Schreiber, Stefan; Schunkert, Heribert; Silander, Kaisa; Sinisalo, Juha; Siscovick, David S.; Smit, Jan H.; Soranzo, Nicole; Sovio, Ulla; Stephens, Jonathan; Surakka, Ida; Swift, Amy J.; Tammesoo, Mari-Liis; Tardif, Jean-Claude; Teder-Laving, Maris; Teslovich, Tanya M.; Thompson, John R.; Thomson, Brian; Toenjes, Anke; Tuomi, Tiinamaija; van Meurs, Joyce B. J.; van Ommen, Gert-Jan; Vatin, Vincent; Viikari, Jorma; Visvikis-Siest, Sophie; Vitart, Veronique; Vogel, Carla I. G.; Voight, Benjamin F.; Waite, Lindsay L.; Wallaschofski, Henri; Walters, G. Bragi; Widen, Elisabeth; Wiegand, Susanna; Wild, Sarah H.; Willemsen, Gonneke; Witte, Daniel R.; Witteman, Jacqueline C.; Xu, Jianfeng; Zhang, Qunyuan; Zgaga, Lina; Ziegler, Andreas; Zitting, Paavo; Beilby, John P.; Farooqi, I. Sadaf; Hebebrand, Johannes; Huikuri, Heikki V.; James, Alan L.; Kaehoenen, Mika; Levinson, Douglas F.; Macciardi, Fabio; Nieminen, Markku S.; Ohlsson, Claes; Palmer, Lyle J.; Ridker, Paul M.; Stumvoll, Michael; Beckmann, Jacques S.; Boeing, Heiner; Boerwinkle, Eric; Boomsma, Dorret I.; Caulfield, Mark J.; Chanock, Stephen J.; Collins, Francis S.; Cupples, L. Adrienne; Smith, George Davey; Erdmann, Jeanette; Froguel, Philippe; Greonberg, Henrik; Gyllensten, Ulf; Hall, Per; Hansen, Torben; Harris, Tamara B.; Hattersley, Andrew T.; Hayes, Richard B.; Heinrich, Joachim; Hu, Frank B.; Hveem, Kristian; Illig, Thomas; Jarvelin, Marjo-Riitta; Kaprio, Jaakko; Karpe, Fredrik; Khaw, Kay-Tee; Kiemeney, Lambertus A.; Krude, Heiko; Laakso, Markku; Lawlor, Debbie A.; Metspalu, Andres; Munroe, Patricia B.; Ouwehand, Willem H.; Pedersen, Oluf; Penninx, Brenda W.; Peters, Annette; Pramstaller, Peter P.; Quertermous, Thomas; Reinehr, Thomas; Rissanen, Aila; Rudan, Igor; Samani, Nilesh J.; Schwarz, Peter E. H.; Shuldiner, Alan R.; Spector, Timothy D.; Tuomilehto, Jaakko; Uda, Manuela; Uitterlinden, Andre; Valle, Timo T.; Wabitsch, Martin; Waeber, Gerard; Wareham, Nicholas J.; Watkins, Hugh; Wilson, James F.; Wright, Alan F.; Zillikens, M. Carola; Chatterjee, Nilanjan; McCarroll, Steven A.; Purcell, Shaun; Schadt, Eric E.; Visscher, Peter M.; Assimes, Themistocles L.; Borecki, Ingrid B.; Deloukas, Panos; Fox, Caroline S.; Groop, Leif C.; Haritunians, Talin; Hunter, David J.; Kaplan, Robert C.; Mohlke, Karen L.; O'Connell, Jeffrey R.; Peltonen, Leena; Schlessinger, David; Strachan, David P.; van Duijn, Cornelia M.; Wichmann, H-Erich; Frayling, Timothy M.; Thorsteinsdottir, Unnur; Abecasis, Goncalo R.; Barroso, Ines; Boehnke, Michael; Stefansson, Kari; North, Kari E.; McCarthy, Mark I.; Hirschhorn, Joel N.; Ingelsson, Erik; Loos, Ruth J. F.

    2010-01-01

    Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and similar to 2.8 million SNPs in up to 123,865 individuals with targeted follow up of

  20. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

    NARCIS (Netherlands)

    E.K. Speliotes (Elizabeth); C.J. Willer (Cristen); S.I. Berndt (Sonja); K.L. Monda (Keri); G. Thorleifsson (Gudmar); A.U. Jackson (Anne); H.L. Allen; C.M. Lindgren (Cecilia); J. Luan; R. Mägi (Reedik); J.C. Randall (Joshua); S. Vedantam (Sailaja); T.W. Winkler (Thomas); L. Qi (Lu); T. Workalemahu (Tsegaselassie); I.M. Heid (Iris); V. Steinthorsdottir (Valgerdur); H.M. Stringham (Heather); E. Wheeler (Eleanor); A.R. Wood (Andrew); T. Ferreira (Teresa); R.J. Weyant (Robert); A.V. Segrè (Ayellet); K. Eestrada (Karol); L. Liang (Liming); J. Nemesh (James); J.H. Park; S. Gustafsson (Stefan); T.O. Kilpeläinen (Tuomas); J. Yang (Joanna); N. Bouatia-Naji (Nabila); T. Eesko (Tõnu); M.F. Feitosa (Mary Furlan); Z. Kutalik (Zoltán); M. Mangino (Massimo); S. Raychaudhuri (Soumya); A. Scherag (Andre); A.V. Smith (Albert Vernon); R.P. Welch (Ryan); J.H. Zhao; K.K.H. Aben (Katja); D. Absher (Devin); N. Amin (Najaf); A.L. Dixon (Anna); E. Fisher (Eeva); N.L. Glazer (Nicole); M.E. Goddard (Michael); N.L. Heard-Costa (Nancy); V. Hoesel (Volker); J.J. Hottenga (Jouke Jan); A. Johansson (Åsa); T. Johnson (Toby); S. Ketkar (Shamika); C. Lamina (Claudia); S. Li (Shengxu); M.F. Moffatt (Miriam); R.H. Myers (Richard); N. Narisu (Narisu); J.R.B. Perry (John); M.J. Peters (Marjolein); M. Preuss (Michael); S. Ripatti (Samuli); F. Rivadeneira Ramirez (Fernando); C. Sandholt (Camilla); L.J. Scott (Laura); N. Timpson (Nicholas); J.P. Tyrer (Jonathan); S. van Wingerden (Sophie); C.C. White (Charles); F. Wiklund (Fredrik); C. Barlassina (Christina); D.I. Chasman (Daniel); M.N. Cooper (Matthew); J.O. Jansson; R.W. Lawrence (Robert); N. Pellikka (Niina); I. Prokopenko (Inga); J. Shi (Jianxin); E. Thiering (Eelisabeth); H. Alavere (Helene); M.T.S. Alibrandi (Maria); P. Almgren (Peter); A.M. Arnold (Alice); T. Aspelund (Thor); L.D. Atwood (Larry); B. Balkau (Beverley); A.J. Balmforth (Anthony); A.J. Bennett (Amanda); Y. Ben-Shlomo; R.N. Bergman (Richard); S.M. Bergmann (Sven); H. Biebermann (Heike); A.I.F. Blakemore (Alexandra); T. Boes (Tanja); L.L. Bonnycastle (Lori); S.R. Bornstein (Stefan); M.J. Brown (Morris); T.A. Buchanan (Thomas); F. Busonero; H. Campbell (Harry); F.P. Cappuccio (Francesco); C. Cavalcanti-Proença (Christine); Y.D.I. Chen (Yii-Der Ida); C.-M. Chen (Chih-Mei); P.S. Chines (Peter); R. Clarke; L. Coin (Lachlan); J. Connell (John); I.N.M. Day (Ian); M. den Heijer (Martin); J. Duan (Jubao); S. Eebrahim (Shah); P. Eelliott (Paul); R. Eelosua (Roberto); G. Eeiriksdottir (Gudny); M.R. Eerdos (Micheal); J.G. Eeriksson (Johan); M.F. Facheris (Maurizio); S.B. Felix (Stephan); P. Fischer-Posovszky (Pamela); A.R. Folsom (Aaron); N. Friedrich (Nele); N.B. Freimer (Nelson); M. Fu (Mao); S. Gaget (Stefan); P.V. Gejman (Pablo); E.J. Geus (Eeco); C. Gieger (Christian); A.P. Gjesing (Anette); A. Goel (Anuj); P. Goyette (Philippe); H. Grallert (Harald); J. Gräßler (Jürgen); D. Greenawalt (Danielle); C.J. Groves (Christopher); V. Gudnason (Vilmundur); C. Guiducci (Candace); A.L. Hartikainen; N. Hassanali (Neelam); A.S. Hall (Alistair); A.S. Havulinna (Aki); C. Hayward (Caroline); A.C. Heath (Andrew); C. Hengstenberg (Christian); A.A. Hicks (Andrew); A. Hinney (Anke); A. Hofman (Albert); G. Homuth (Georg); J. Hui (Jennie); W. Igl (Wilmar); C. Iribarren (Carlos); B. Isomaa (Bo); K.B. Jacobs (Kevin); I. Jarick (Ivonne); E. Jewell (Eelizabeth); U. John (Ulrich); T. Jørgensen (Torben); P. Jousilahti (Pekka); A. Jula (Antti); M. Kaakinen (Marika); E. Kajantie (Eero); R.C. Kaplan (Robert); S. Kathiresan (Sekar); J. Kettunen (Johannes); L. Kinnunen (Leena); J.W. Knowles (Joshua); I. Kolcic (Ivana); I.R. König (Inke); S. Koskinen (Seppo); P. Kovacs (Peter); J. Kusisto (Johanna); P. Kraft (Peter); K. Kvaløy (Kirsti); J. Laitinen (Jaana); O. Lantieri (Olivier); C. Lanzani (Chiara); L.J. Launer (Lenore); C. Lecoeur (Cécile); T. Lehtimäki (Terho); G. Lettre (Guillaume); J. Liu (Jianjun); M.L. Lokki; M. Lorentzon (Mattias); R.N. Luben (Robert); B. Ludwig (Barbara); P. Manunta (Paolo); D. Marek (Diana); M. Marre (Michel); N.G. Martin (Nicholas); W.L. McArdle (Wendy); M.I. McCarthy (Mark); B. McKnight (Barbara); T. Meitinger (Thomas); O. Melander (Olle); D. Meyre (David); K. Midthjell (Kristian); G.W. Montgomery (Grant); M.A. Morken (Mario); A.D. Morris (Andrew); R. Mulic (Rosanda); J.S. Ngwa; M. Nelis (Mari); M.J. Neville (Matthew); D.R. Nyholt (Dale); C.J. O'Ddonnell (Christopher); S. O'Rahilly (Stephen); K. Ong (Ken); B.A. Oostra (Ben); G. Paré (Guillaume); A.N. Parker (Alex); M. Perola (Markus); I. Pichler (Irene); K.H. Pietilainen (Kirsi Hannele); C.P. Platou (Carl); O. Polasek (Ozren); A. Pouta (Anneli); S. Rafelt (Suzanne); O. Raitakari (Olli); N.W. Rayner (Nigel William); M. Ridderstråle (Martin); W. Rief (Winfried); A. Ruokonen (Aimo); N.R. Robertson (Neil); P. Rzehak (Peter); V. Salomaa (Veikko); A.R. Sanders (Alan); M.S. Sandhu (Manjinder); S. Sanna (Serena); J. Saramies (Jouko); M.J. Savolainen (Markku); S. Schipf (Sabine); S. Schreiber (Stefan); H. Schunkert (Heribert); K. Silander (Kaisa); J. Sinisalo (Juha); D.S. Siscovick (David); J.H. Smit (Jan); N. Soranzo (Nicole); U. Sovio (Ulla); J. Stephens (Jonathan); I. Surakka (Ida); A.J. Swift (Amy); M.L. Tammesoo; J.-C. Tardif (Jean-Claude); M. Teder-Laving (Maris); T.M. Teslovich (Tanya); J.R. Thompson (John); B. Thomson (Brian); A. Tönjes (Anke); T. Tuomi (Tiinamaija); J.B.J. van Meurs (Joyce); G.J. van OMen; V. Vatin (Vincent); J. Viikari (Jorma); S. Visvikis-Siest (Sophie); V. Vitart (Veronique); C.I. Vogel (Carla); B.F. Voight (Benjamin); L. Waite (Lindsay); H. Wallaschofski (Henri); G.B. Walters (Bragi); E. Widen (Elisabeth); S. Wiegand (Susanna); S.H. Wild (Sarah); G.A.H.M. Willemsen (Gonneke); D.R. Witte (Deniel); J.C.M. Witteman (Jacqueline); J. Xu (Jianfeng); Q. Zhang (Qunyuan); L. Zgaga (Lina); A. Ziegler (Andreas); P. Zitting (Paavo); J.P. Beilby (John); I.S. FarOqi (Ssadaf); J. Hebebrand (Johannes); H.V. Huikuri (Heikki); A. James (Alan); M. Kähönen (Mika); D.F. Levinson (Douglas); F. MacCiardi (Fabio); M.S. Nieminen (Markku); C. Ohlsson (Claes); C. Palmer (Cameron); P.M. Ridker (Paul); M. Stumvoll (Michael); J.S. Beckmann (Jacques); H. Boeing (Heiner); E.A. Boerwinkle (Eric); D.I. Boomsma (Dorret); M. Caulfield (Mark); S.J. Chanock (Stephen); F.S. Collins (Francis); L.A. Cupples (Adrienne); J. Eerdmann (Jeanette); P. Frogue (Philippe); H. Grönberg (Henrik); U. Gyllensten (Ulf); T. Hansen (Torben); T.B. Harris (Tamara); A.T. Hattersley (Andrew); R.B. Hayes (Richard); J. Heinrich (Joachim); F.B. Hu (Frank); K. Hveem (Kristian); T. Illig (Thomas); M.R. Järvelin; J. Kaprio (Jaakko); F. Karpe (Fredrik); K-T. Khaw (Kay-Tee); L.A.L.M. Kiemeney (Bart); H. Krude; M. Laakso (Markku); D.A. Lawlor (Debbie); A. Metspalu (Andres); P. Munroe (Patricia); W.H. Ouwehand (Willem); O. Pedersen (Oluf); B.W.J.H. Penninx (Brenda); P.P. Pramstaller (Peter Paul); T. Quertermous (Thomas); T. Reinehr (Thomas); A. Rissanen (Aila); I. Rudan (Igor); N.J. Samani (Nilesh); P.E.H. Schwarz (Peter); A.R. Shuldiner (Alan); T.D. Spector (Timothy); J. Tuomilehto (Jaakko); M. Uda (Manuela); A.G. Uitterlinden (André); T.T. Valle (Timo); M. Wabitsch (Martin); G. Waeber (Gérard); N.J. Wareham (Nick); H. Watkins (Hugh); J.F. Wilson (James); A.F. Wright (Alan); M.C. Zillikens (Carola); N. ChatterjE (Nilanjan); S.A. McCarroll (Steve); S. Purcell (Shaun); E.E. Schadt (Eric); P.M. Visscher (Peter); T.L. Assimes (Themistocles); I.B. Borecki (Ingrid); P. Deloukas (Panagiotis); C.S. Fox (Caroline); L. Groop (Leif); T. Haritunians (Talin); D.J. Hunter (David); K.L. Mohlke (Karen); J.R. O'ConneL (Jeffrey); L. Peltonen (Leena Johanna); D. SchleSinger (David); D.P. Strachan (David); R.M. Watanabe (Richard); C.M. van Duijn (Cock); H.E. Wichmann (Heinz Erich); T.M. Frayling (Timothy); U. Thorsteinsdottir (Unnur); G.R. Abecasis (Gonçalo); M. Boehnke (Michael); K. StefanSon (Kari); K.E. North (Kari); M.I. McArthy (Mark); J.N. Hirschhorn (Joel); E. IngelSon (Erik); R.J.F. Loos (Ruth); M.N. Weedon (Michael)

    2010-01-01

    textabstractObesity is globaLy prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined aSociations betwEn body maS index and ĝ̂1/42.8 miLion SNPs in up to 123,865 individuals with targeted foLow up of

  1. Actinide production in the reaction of heavy ions with curium-248

    International Nuclear Information System (INIS)

    Chemical experiments were performed to examine the usefulness of heavy ion transfer reactions in producing new, neutron-rich actinide nuclides. A general quasi-elastic to deep-inelastic mechanism is proposed, and the utility of this method as opposed to other methods (e.g. complete fusion) is discussed. The relative merits of various techniques of actinide target synthesis are discussed. A description is given of a target system designed to remove the large amounts of heat generated by the passage of a heavy ion beam through matter, thereby maximizing the beam intensity which can be safely used in an experiment. Also described is a general separation scheme for the actinide elements from protactinium (Z=91) to mendelevium (Z=101), and fast specific procedures for plutonium, americium and berkelium. The cross sections for the production of several nuclides from the bombardment of 248Cm with 18O, 86Kr and 136Xe projectiles at several energies near and below the Coulomb barrier were determined. The results are compared with yields from 48Ca and 238U bombardments of 248Cm. Simple extrapolation of the product yields into unknown regions of charge and mass indicates that the use of heavy ion transfer reactions to produce new, neutron-rich above-target species is limited. The substantial production of neutron-rich below-target species, however, indicates that with very heavy ions like 136Xe and 238U the new species 248Am, 249Am and 247Pu should be produced with large cross sections from a 248Cm target. A preliminary, unsuccessful attempt to isolate 247Pu is outlined. The failure is probably due to the half life of the decay, which is calculated to be less than 3 minutes. The absolute gamma ray intensities from 251Bk decay, necessary for calculating the 251Bk cross section, are also determined

  2. 249株流感嗜血杆菌的分离与耐药性分析%Analysis on Isolation and Antibiotic Resistance of 249 Strains of Haemophilus influenzae

    Institute of Scientific and Technical Information of China (English)

    曹敏晖; 曹友德; 李浩; 蔡瑞云

    2011-01-01

    目的 了解流感嗜血杆菌(Hi)的检出状况与耐药情况,指导临床合理用药.方法 统计分析2007-2010年我院Hi的分离与耐药情况.结果 在1052份痰及咽拭子标本中分离出Hi 210株,在242份胆汁标本中分离出Hi 16株,在203份胸腹水标本中分离出Hi 12株,在163份眼、耳拭子标本中分离出Hi 11株.体外药敏结果显示Hi对复方磺胺甲恶哇耐药性最高为63.5%,氨苄西林次之为46.2%,而对阿莫西林/棒酸、利福平、头孢呋辛、头孢噻肟、亚氨培南敏感,耐药率≤2.0%.结论 Hi在呼吸道标本中的检出率最高,眼、耳拭子标本中次之,在胆汁、胸腹水中亦有检出.建议眼、耳拭子及胆汁、胸腹水标本作细菌培养时也应同时接种哥伦比亚血平板(COS)、淋球菌选择性平板(VCA)及嗜血杆菌选择性平板(HAE),Hi感染的治疗应首选复方阿莫西林、头孢二代或三代类抗生素.%Objective To investigate the isolation rate and antibiotic resistance rate of Haemophilus influenzae, and to guide the rational use of antibiotic therapy in clinical practice. Methods The data about the isolation rate and antibiotic resistance rate of Haemophilus influenzae from 2007 to 2010 were analyzed with SPSS11.0 statistical software. Results Totally 210 strains of Haemophilus influenzae were isolated from 1,052 specimens of sputum and pharyngeal secretion, 16 strains isolated from 242 bile specimens, 12 strains isolated from 203 hydrothoraxs specimens, and 11 strains isolated from 163 specimens of eye or ear secretion. In vitro drug- sensitivity test showed that the resistance rate of Haemophilus influenzae to trimethoprime sulfanomicles was the highest (63.5%), followed by ampicillin (46.2%). But the resistance rates to amoxicillin/clavalanic acid, rifampicine, cefuroxime, cefotaxime and imipenem were very low (≤2.0%). Conclusions Heamophilus influenzae could be isolated from the secretions of respiratory track, eye, ear, bile, and hydrothoraxs. It is necessary that using COS, VCA f- lat, and HAE while performing bacterial culture of the secretions of eye, ear, bile, and hydrothoraxs. The therapy of Heamophilus influenzae infection should choose the antibiotics, such as amoxicillin/ clavalanic acid, cefuroxime and cefotaxime.

  3. SU-E-T-249: Neutron Model Upgrade for Radiotherapy Patients Monitoring Using a New Online Detector

    Energy Technology Data Exchange (ETDEWEB)

    Irazola, L; Sanchez Doblado, F. [Departamento de Fisiologia Medica y Biofisica, Universidad de Sevilla (Spain); Servicio de Radiofisica, Hospital Universitario Virgen Macarena, Sevilla (Spain); Lorenzoli, M; Pola, A. [Politecnico di Milano, Departimento di Ingegneria Nuclear, Milano (Italy); Terron, J.A. [Servicio de Radiofisica, Hospital Universitario Virgen Macarena, Sevilla (Spain); Bedogni, R. [Laboratori Nazionali di Frascati, Istituto Nazionale di Fisica Nucleare (INFN) (Italy); Sanchez Nieto, B. [Instituto de Fisica, Pontificia Universidad Catolica de Chile, Santiago (Chile); Romero-Exposito, M. [Departamento de Fisica, Universitat Autonoma de Barcelona (Spain)

    2014-06-01

    Purpose: The purpose of this work is to improve the existing methodology to estimate neutron equivalent dose in organs during radiotherapy treatments, based on a Static Random Access Memory neutron detector (SRAMnd) [1]. This is possible thanks to the introduction of a new digital detector with improved characteristics, which is able to measure online the neutron fluence rate in the presence of an intense photon background [2]. Its reduced size, allows the direct estimation of doses in specific points inside an anthropomorphic phantom (NORMA) without using passive detectors as TLD or CR-39. This versatility will allow not only to improve the existing models (generic abdomen and H and N [1]) but to generate more specific ones for any technique. Methods: The new Thermal Neutron Rate Detector (TNRD), based on a diode device sensitized to thermal neutrons, have been inserted in 16 points of the phantom. These points are distributed to infer doses to specific organs. Simultaneous measurements of these devices and a reference one, located in front of the gantry, have been performed for the mentioned generic treatments, in order to improve the existing model. Results: These new devices have shown more precise since they agree better with Monte Carlo simulations. The comparison of the thermal neutron fluence, measured with TNRD, and the existing models, converted from events to fluence, shows an average improvement of (3.90±3.37) % for H and N and (12.61±9.43) % for abdomen, normalized to the maximum value. Conclusion: This work indicates the potential of these new devices for more precise neutron equivalent dose estimation in organs, as a consequence of radiotherapy treatments. The simplicity of the process makes possible to establish more specific models that will provide a better dose estimation. References[1] Phys Med Biol 2012; 57:6167–6191.[2] A new active thermal neutron detector. Radiat. Prot. Dosim. (in press)

  4. 17 CFR 249b.101 - Form TA-W, notice of withdrawal from registration as transfer agent.

    Science.gov (United States)

    2010-04-01

    ...))) Editorial Note: For Federal Register citations affecting Form TA-W, see the List of CFR Sections Affected... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Form TA-W, notice of... TA-W, notice of withdrawal from registration as transfer agent. This form shall be used...

  5. Metabolic products of microorganisms. 249. Tetracenomycins B3 and D3, key intermediates of the elloramycin and tetracenomycin C biosynthesis.

    Science.gov (United States)

    Rohr, J; Eick, S; Zeeck, A; Reuschenbach, P; Zähner, H; Fiedler, H P

    1988-08-01

    Tetracenomycins B3 and D3, besides tetracenomycin D (D1), were produced by a blocked mutant of the elloramycin producer Streptomyces olivaceus TU 2353. The compounds were isolated as red powders, and their structures were elucidated by comparing their physicochemical data with those of the known tetracenomycins A2, B1, B2, D and E. Tetracenomycin B3 (2), the main compound, and tetracenomycin D (3) were antibiotically inactive against Gram-positive and Gram-negative bacteria, whereas tetracenomycin D3 (1) showed a moderate activity against Bacillus subtilis and Arthrobacter aurescens. Tetracenomycin B3 (2) is the key intermediate where the biosynthesis of the elloramycins branches off from the line leading to tetracenomycin C (5) as the final product of the tetracenomycin biosynthesis branch.

  6. Are taxonomists required to bend to the will of bioinformatics? A response to Johnson (Skaphion 2:49)

    Science.gov (United States)

    Author names on the end of a species epithet are essential to stable taxonomy. These names are absolutely required in the case of homonymy, but they are also useful for obtaining original descriptions, locating type depositories, and determining the quality of a species concept. In this paper I ar...

  7. Characterization of the in vitro expressed autoimmune rippling muscle disease immunogenic domain of human titin encoded by TTN exons 248-249

    International Nuclear Information System (INIS)

    Highlights: → Affinity purification of the autoimmune rippling muscle disease immunogenic domain of titin. → Partial sequence analysis confirms that the peptides is in the I band region of titin. → This region of the human titin shows high degree of homology to mouse titin N2-A. -- Abstract: Autoimmune rippling muscle disease (ARMD) is an autoimmune neuromuscular disease associated with myasthenia gravis (MG). Past studies in our laboratory recognized a very high molecular weight skeletal muscle protein antigen identified by ARMD patient antisera as the titin isoform. These past studies used antisera from ARMD and MG patients as probes to screen a human skeletal muscle cDNA library and several pBluescript clones revealed supporting expression of immunoreactive peptides. This study characterizes the products of subcloning the titin immunoreactive domain into pGEX-3X and the subsequent fusion protein. Sequence analysis of the fusion gene indicates the cloned titin domain (GenBank ID: (EU428784)) is in frame and is derived from a sequence of N2-A spanning the exons 248-250 an area that encodes the fibronectin III domain. PCR and EcoR1 restriction mapping studies have demonstrated that the inserted cDNA is of a size that is predicted by bioinformatics analysis of the subclone. Expression of the fusion protein result in the isolation of a polypeptide of 52 kDa consistent with the predicted inferred amino acid sequence. Immunoblot experiments of the fusion protein, using rippling muscle/myasthenia gravis antisera, demonstrate that only the titin domain is immunoreactive.

  8. Characterization of the in vitro expressed autoimmune rippling muscle disease immunogenic domain of human titin encoded by TTN exons 248-249

    Energy Technology Data Exchange (ETDEWEB)

    Zelinka, L. [Biomedical Sciences Program, Kent State University, Kent, OH (United States); McCann, S.; Budde, J.; Sethi, S.; Guidos, M.; Giles, R. [Center for Applied Chemical Biology, Department of Biological Sciences, Youngstown State University, One University Plaza, Youngstown, OH 44555 (United States); Walker, G.R., E-mail: grwalker@ysu.edu [Center for Applied Chemical Biology, Department of Biological Sciences, Youngstown State University, One University Plaza, Youngstown, OH 44555 (United States); Biomedical Sciences Program, Kent State University, Kent, OH (United States)

    2011-08-05

    Highlights: {yields} Affinity purification of the autoimmune rippling muscle disease immunogenic domain of titin. {yields} Partial sequence analysis confirms that the peptides is in the I band region of titin. {yields} This region of the human titin shows high degree of homology to mouse titin N2-A. -- Abstract: Autoimmune rippling muscle disease (ARMD) is an autoimmune neuromuscular disease associated with myasthenia gravis (MG). Past studies in our laboratory recognized a very high molecular weight skeletal muscle protein antigen identified by ARMD patient antisera as the titin isoform. These past studies used antisera from ARMD and MG patients as probes to screen a human skeletal muscle cDNA library and several pBluescript clones revealed supporting expression of immunoreactive peptides. This study characterizes the products of subcloning the titin immunoreactive domain into pGEX-3X and the subsequent fusion protein. Sequence analysis of the fusion gene indicates the cloned titin domain (GenBank ID: (EU428784)) is in frame and is derived from a sequence of N2-A spanning the exons 248-250 an area that encodes the fibronectin III domain. PCR and EcoR1 restriction mapping studies have demonstrated that the inserted cDNA is of a size that is predicted by bioinformatics analysis of the subclone. Expression of the fusion protein result in the isolation of a polypeptide of 52 kDa consistent with the predicted inferred amino acid sequence. Immunoblot experiments of the fusion protein, using rippling muscle/myasthenia gravis antisera, demonstrate that only the titin domain is immunoreactive.

  9. Book Review: Philosophy and geometry: theoretical and historical issues. Lorenzo Magnani, Kluwer Academic Publishers, Dordrecht, 2001, pp. xix + 249, US 88. ISBN 0-792-36933-5

    Science.gov (United States)

    Torretti, Roberto

    The best philosophers have been fascinated with geometry ever since the inception of both traditions in 5th century Greece. They have perceived the apparent certainty of geometrical propositions as an intimation that an equally secure knowledge can be had on a subject of the greatest practical concern, viz., the principles of morals. They also have sought to find-as is their wont-reasons for that certainty. This search has given rise to the theoretical and historical issues magisterially reviewed in this book by Lorenzo Magnani. He focuses his attention especially on Kant (Chapters 2 and 3), Poincaré (Chapter 5) and Husserl (Chapter 7.2), and on their original and importantly different ways of explaining the true nature and source of geometrical truth. Despite their diversity, all three can be said to share a trait that is rarely emphasized and which Magnani brings out in full force in his study of Kant. Chapter 2 is called "Geometry: the Model of Knowledge", and his detailed and very able presentation of Kant's philosophy of geometry in this chapter and the next stresses the paradigmatic role of geometrical knowledge in Kant's conception of science. This role is even clearer in the case of Poincaré, whose conventionalism was rooted in his view of geometry but was eventually extended to all the foundations of physics. An enterprising scholar might even try to make a similar point with regard to Husserl, whose views on the establishment of objectivity and science appear to fit geometry better than any other branch of knowledge.

  10. 17 CFR 249.820 - Form 19b-4(e) for the listing and trading of new derivative securities products by self...

    Science.gov (United States)

    2010-04-01

    ... self-regulatory organization's listing and trading of a new derivative securities product that is not deemed a proposed rule change, pursuant to Rule 19b-4(e) under the Act (17 CFR 240.19b-4(e)). Editorial Note: For Federal Register citations affecting Form 19b-4(e), see the List of CFR Sections...

  11. 33 CFR 207.249 - Ouachita and Black Rivers, Ark. and La., Mile 0.0 to Mile 338.0 (Camden, Ark.) above the mouth of...

    Science.gov (United States)

    2010-07-01

    ... other lockages, then separate lockages shall be made. Dangerous cargoes are described in 46 CFR part 146... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Ouachita and Black Rivers, Ark. and La., Mile 0.0 to Mile 338.0 (Camden, Ark.) above the mouth of the Black River; the Red River,...

  12. SU-E-J-249: Characterization of Gynecological Tumor Heterogeneity Using Texture Analysis in the Context of An 18F-FDG PET Adaptive Protocol

    Energy Technology Data Exchange (ETDEWEB)

    Nawrocki, J [Duke University Medical Physics Graduate Program, Durham, NC (United States); Chino, J; Craciunescu, O [Duke University Medical Center Department of Radiation Oncology, Durham, NC (United States); Das, S [University of North Carolina School of Medicine, Chapel Hill, NC (United States)

    2015-06-15

    Purpose: We propose a method to examine gynecological tumor heterogeneity using texture analysis in the context of an adaptive PET protocol in order to establish if texture metrics from baseline PET-CT predict tumor response better than SUV metrics alone as well as determine texture features correlating with tumor response during radiation therapy. Methods: This IRB approved protocol included 29 women with node positive gynecological cancers visible on FDG-PET treated with EBRT to the PET positive nodes. A baseline and intra-treatment PET-CT was obtained. Tumor outcome was determined based on RECIST on posttreatment PET-CT. Primary GTVs were segmented using 40% threshold and a semi-automatic gradient-based contouring tool, PET Edge (MIM Software Inc., Cleveland, OH). SUV histogram features, Metabolic Volume (MV), and Total Lesion Glycolysis (TLG) were calculated. Four 3D texture matrices describing local and regional relationships between voxel intensities in the GTV were generated: co-occurrence, run length, size zone, and neighborhood difference. From these, 39 texture features were calculated. Prognostic power of baseline features derived from gradientbased and threshold GTVs were determined using the Wilcoxon rank-sum test. Receiver Operating Characteristics and logistic regression was performed using JMP (SAS Institute Inc., Cary, NC) to find probabilities of predicting response. Changes in features during treatment were determined using the Wilcoxon signed-rank test. Results: Of the 29 patients, there were 16 complete responders, 7 partial responders, and 6 non-responders. Comparing CR/PR vs. NR for gradient-based GTVs, 7 texture values, TLG, and SUV kurtosis had a p < 0.05. Threshold GTVs yielded 4 texture features and TLG with p < 0.05. From baseline to intra-treatment, 14 texture features, SUVmean, SUVmax, MV, and TLG changed with p < 0.05. Conclusion: Texture analysis of PET imaged gynecological tumors is an effective method for early prognosis and should be used complimentary to SUV metrics, especially when using gradient based segmentation.

  13. Evidence for association of D1S249 locus on human chromosome 1 with the susceptibility to essential hypertension in Han Chinese

    Institute of Scientific and Technical Information of China (English)

    ZHENG; Yong; (

    2001-01-01

    [1]Jeunemaitre, X., Soubrier, F., Kotelevtsev, Y. V. et al., Molecular basis of hypertension: role of angiotensinogen, Cell, 1993, 71: 169.[2]Hingorani, A. D., Sharma, P., Jia, H. et al., Blood pressure and M235T polymorphism of the angiotensinogen gene, Hypertension, 1996, 28: 907.[3]Liu, Y., Zhou, W. Y., Qiu, C. C. et al., Association analysis of polymorphisms of ACE gene and AGT gene with essential hypertension in Chinese Han's population, Chin. Med. Sci. J., 1998, 13(2): 71.[4]Davies, E., Bonnar, D. A., Lathrop, G. M. et al., Human angiotensin II type I receptor locus, CA repeat polymorphism and genetic mapping, Hum. Mol. Genet., 1994, 3: 838.[5]Kainulainen, K., Perola, M., Terwilliger, J. et al., Evidence for involvement of the type I angiotensin II receptor locus in essential hypertension, Hypertension, 1999, 33: 844.[6]Wang, W. Y. S., Zee, R. Y. L., Morris, B. J. et al., Association of angiotensin II type I receptor gene polymorphism with essential hypertension, Clin. Genet., 1997, 51: 31.[7]Mastana, S., Nunn, J., Angiotensin-converting enzyme deletion polymorphism is associated with hypertension in a sikh population, Human Hered., 1997, 47: 250.[8]Poirier, O., Georges, J. L., Ricard, S. et al., New polymorphisms of the angiotensin II type I receptor gene and their associations with myocardial infarction and blood pressure: the ECTIM study, J. of Hypertension, 1998, 16: 1443.[9]Liu, Y., Qiu, C. C., Zhou, W. Y. et al., Gene polymorphisms of the renin-angiotensin system in essential hypertension, Chinese Medical Journal, 1999, 112(2): 115.[10] Todd, J. A., Genetic analysis of type I diabetes using whole genome approaches, Proc. Natl. Acad. Sci. USA, 1995, 92: 8560.[11] Hanis, C. L., Boerwinkle, E., Chakraborty, R. et al., A genome-wide search for human non-insulin-dependent (type II) diabetes genes reveals a major susceptibility locus on chromosome 2, Nature Genetics, 1996, 13: 161.[12] Hager, J., Dina, C., Franke, S. et al., A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10, Nature Genetics, 1998, 20: 304.[13] Schuster, H., Wienker, T. F., Bahring, S. et al., Severe autosomal dominant hypertension and brachydactyly in a unique Turkish Kindred maps to human chromosome 12, Nature Genetics, 1996, 13: 98.[14] Baima, J., Nicolaou, M., Schwartz, F. et al., Evidence for linkage between essential hypertension and a putative locus on human chromosome 17, Hypertension, 1999, 34: 4.[15] Wright, F. A., O'connor, D. T., Roberts, E. et al., Genome scan for blood pressure loci in mice, Hypertension, 1999, 34: 625.[16] Cox, N. J., Baker, L., Spielman, R. S., Insulin-gene sharing in sib pairs with insulin dependent diabetes mellitus: no evidence for linkage, Am. J. Hum. Genet., 1988, 42: 167.[17] Bonnardeaux, A., Davies, E., Jeunemaitre, X. et al., Angiotensin II type I receptor gene polymorphisms in human essential hypertension, Hypertension, 1994, 24: 63.

  14. Sylvie Schweitzer, Femmes de pouvoir. Une histoire de l’égalité professionnelle en Europe (XIXe - XXIe siècle, Paris, Payot, 2010, 249 p.

    Directory of Open Access Journals (Sweden)

    Isabelle Ernot

    2010-07-01

    Full Text Available Avec cet ouvrage, Sylvie Schweitzer poursuit son investigation autour de l’histoire du travail des femmes. L’étude se focalise particulièrement sur la voie du savoir, à travers la question des diplômées et de leur accession progressive à des professions valorisantes et de pouvoir, dans le cadre d’un temps long de cent cinquante années, courant du milieu du XIXe au début du XXIe siècle. Si la France constitue le cadre de référence essentiel, cet essai d’histoire comparée regarde aussi vers l’e...

  15. Discovery of Isotopes of the Transuranium Elements with 93 <= Z <= 98

    CERN Document Server

    Fry, C

    2012-01-01

    One hundred and five isotopes of the transuranium elements neptunium, plutonium, americium, curium, berkelium and californium have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  16. 249例细胞学、HPV-DNA分型检测在宫颈癌初筛中的意义分析%Analysis on significances of cytology and HPV-DNA genotyping in primary screening of 249 cases with cervical cancer

    Institute of Scientific and Technical Information of China (English)

    林莉; 林清平; 陈小苑; 徐朝斌

    2013-01-01

    Objective:To analyze and understand the significances of cytology and HPV-DNA genotyping in primary screening of cervical cancer by conducting cytology test,HPV-DNA genotyping,and biopsy among patients from the hospital from August 10th,2010 to October 1 st,2011.Methods:Cytological screening:all the patients were detected by liquid-based Thin Prep cytology test (TCT) ; the diagnostic criterion of TCT was TBS classification; HPV-DNA genotyping:cervical canal samples of all the patients were collected by sampling kit of dot blot,supervising technicians conducted dot blot and analyzed the results,21 kinds of cancer type HPV DNA currently known were detected,including 13 high risk HPV types and 8 low risk and common HPV subtype.All the women underwent electronic colposcopy (SLC-2000,Shenzhen),the operation was conducted by specialized obstetricians and gynecologists,and suspicious lesions underwent colposcopic localization and biopsy.Results:The total sensitivity of joint detection of cytological test and HPV-DNA genotyping was 91.82%,which was significantly higher than those of simple cytological test and simple HPV-DNA genotyping,especially for cervical intraepithelial neoplasia Ⅱ or above lesions,the sensitivity was as high as 100.00%,so joint detection of cytological test and HPV-DNA genotyping was the most reliable method for screening of cervical cancer,which could reduce the missed diagnostic rate to a minimal level.Conclusion:Cytological test is the most reliable method for primary screening of cervical cancer currently,HPV-DNA genotyping only can assist cytological test for primary screening,but it cant replace cytological test completely.HPV-DNA genotyping is a best method for treatment of ASCUS,which can isolate high risk population of ASCUS effectively.Compared with simple cytological test,the sensitivity of joint detection of cytological test and HPV-DNA genotyping increases,but the screening cost increases greatly,it is recommended to use the method in economically developed areas.%目的:通过对在2010年8月10日~2011年10月1日期间厦门市第二医院有做细胞学、HPV-DNA分型和活检的患者分析了解细胞学、HPV-DNA分型检测在宫颈癌初筛中意义.方法:细胞学筛查:所有进入研究的患者均采用泰普生物科学(中国)有限公司的薄层液基细胞学技术(TCT)产品进行检测.细胞学诊断标准采用TBS分类法.HPV-DNA分型检测:所有进入研究的患者用凯普公司点杂交的采样工具包从宫颈管采集标本,并由主管技师进行点杂交检测操作并做出分析,检测目前已知的21种致癌型HPV DNA(即13种高危HPV及8种低危和中国人常见亚型HPV).所有进入研究的妇女使用深圳金科威公司的SLC-2000型电子阴道镜,并由专门的妇产科医师进行检查操作,对可疑病灶进行镜下定位活检.结果:细胞学与HPV-DNA分型检测联合筛查总敏感度是91.82%,均高于2种方法单独检测时的敏感度,尤其是CIN2及以上的病变敏感度高达100.00%,因此细胞学与HPV-DNA分型检测联合筛查,是最稳妥的宫颈癌筛查方案,可以把漏诊率降到最低.结论:细胞学目前还是最可靠的宫颈癌初筛方法,HPV-DNA分型检测只能辅助细胞学进行初筛,还不能完全取代它.对于细胞学ASCUS的处理,HPV-DNA分型检测是最好的一个办法,可以有效地分离出ASCUS中高危人群.细胞学与HPV-DNA分型检测联合筛查与单独做细胞学相比敏感性有所提高,但是筛查成本大大增加,建议在经济较发达的地区使用这一种方法.

  17. Protein (Viridiplantae): 359495301 [PGDBj - Ortholog DB

    Lifescience Database Archive (English)

    Full Text Available D: LOW QUALITY PROTEIN: valencene synthase Vitis vinifera MELPKLLHSYFPSQFSKXSVLLPFQKINMSGQVLASPLGQFPELENRPVV...24:4279 3398:4279 71240:1195 91827:1195 71275:2879 91834:249 403667:249 3602:249 3603:249 29760:249 PREDICTE

  18. Protein (Viridiplantae): 359495295 [PGDBj - Ortholog DB

    Lifescience Database Archive (English)

    Full Text Available D: LOW QUALITY PROTEIN: valencene synthase Vitis vinifera MSTQVSASSLAQIPKPKNRPVANYHPNIWGDQFISYIPEDKVTRACKEEQ...24:4279 3398:4279 71240:1195 91827:1195 71275:2879 91834:249 403667:249 3602:249 3603:249 29760:249 PREDICTE

  19. Neutron multiplicities for the transplutonium nuclides

    International Nuclear Information System (INIS)

    This paper continues, with respect to the transplutonium nuclides, earlier efforts to collate and evaluate data from the scientific literature on the prompt neutron multiplicity distribution from fission and its first moment = ΣnuPnu. The isotopes considered here for which P/sub nu/ and or data (or both) were found in the literature are of americium (Am), curium (Cm), berkelium (Bk), californium (Cf), einsteinium (Es), fermium (Fm), and nobelium (No)

  20. Assessment of dietary exposure to annatto (E160b), nitrites (E249-250), sulphites (E220-228) and tartaric acid (E334) in the French population: the second French total diet study.

    Science.gov (United States)

    Bemrah, N; Vin, K; Sirot, V; Aguilar, F; Ladrat, A-C; Ducasse, C; Gey, J-L; Rétho, C; Nougadere, A; Leblanc, J-C

    2012-01-01

    The results of the assessment of the dietary exposure to annatto, nitrites, tartaric acid and sulphites within the framework of the second French total diet study (TDS) are reported. These 4 additives were selected from the Bemrah et al. study [Bemrah N, Leblanc JC, Volatier JL. 2008. Assessment of dietary exposure in the French population to 13 selected food colours, preservatives, antioxidants, stabilizers, emulsifiers and sweeteners. Food Addit Contam B. 1(1):2-14] on 13 food additives which identified a possible health risk for annatto, sulphites and nitrites and a lack of data for tartaric acid. Among the composite samples selected for the whole TDS, 524 were analysed for additives (a sample was analysed for a given additive when it was identified as a major contributor for this additive only): 130 for tartaric acid, 135 for nitrites, 59 for annatto and 200 for sulphites. Estimated concentrations (minimum lower bound to maximum upper bound) vary nationally from 0 to 9 mg/kg for annatto, 0 to 420 mg/kg for tartaric acid, 0 to 108 mg/kg for sulphites and 0 to 3.4 mg/kg for nitrites. Based on the analytical results, the dietary exposure was calculated for adults and children, separately, using lower bound and upper bound assumptions. The European ADIs for these 4 additives were not exceeded except for the dietary exposure for sulphites among 2.9% of the adult population, where the major contributors were alcoholic drinks and especially wine under both hypotheses (lower and upper bound).

  1. Vlasov B. Natural properties of Karst lakes in Belarus / B. Vlasov // Lakes and artificial water reservoirs – functioning, revitalization and protection. – Cosnowiec, 2005. – Р. 249–255.

    OpenAIRE

    Vlasov, Boris

    2005-01-01

    Abstract: Karst lakes of Belarus belong to the azonal type and are distributed in Polesje region in the area of superficial deposition of chalk rocks. Specific features of these type lakes include: small water surface, tunneled form of a hollow, low water exchange rate and increased level of water mineralization; the lakes refer to mesotrophic or eutrophic types.

  2. RESGPSPNTS_JD249.SHP: Navigation and Bathymetry Points of Ship Position During Continuous Resistivity Profile Data Collection in the Potomac River/Chesapeake Bay on Sept. 6, 2006 on USGS Cruise 06018

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — In order to test hypotheses about groundwater flow under and into Chesapeake Bay, geophysical surveys were conducted by U.S. Geological Survey (USGS) scientists on...

  3. Nuclear Liability Act of 8 March 1968 (No. 45) as amended by an Act of 10 May 1974 (No. 249) and by an Act of 22 December 1982 (No. 1275)

    International Nuclear Information System (INIS)

    The amendments to this Act fall into two categories. The first category of amendments enabled Sweden to ratify two 1982 Protocols amending the Paris Convention and the Brussels Supplementary Convention respectively. The other amendments raise the nuclear operator's liability from 50 million to 500 million Swedish crowns per incident and introduce a State liability over and above compensation available under the Brussels Convention, thus raising the aggregate amount of compensation to 3,000 million Swedish crowns. (NEA)

  4. Multibeam collection for TN249: Multibeam data collected aboard Thomas G. Thompson from 2010-05-10 to 2010-06-14, departing from Dutch Harbor, AK and returning to Dutch Harbor, AK

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  5. RESGPSLNS_JD249.SHP: Ship Trackline along which Continuous Resistivity Profile Data was Collected in the Potomac River/Chesapeake Bay on Sept., 6, 2006 on USGS Cruise 06018

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — In order to test hypotheses about groundwater flow under and into Chesapeake Bay, geophysical surveys were conducted by U.S. Geological Survey (USGS) scientists on...

  6. CTD data of the Hawaii Ocean Time-series (HOT) program in the North Pacific 100 miles north of Oahu, Hawaii for cruises HOT249-258 during 2013 (NODC Accession 0125647)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The HOT program makes repeated observations of the physics, biology and chemistry at a site approximately 100 km north of Oahu, Hawaii. The program began in 1988....

  7. 17 CFR 41.11 - Method for determining market capitalization and dollar value of average daily trading volume...

    Science.gov (United States)

    2010-04-01

    ... Form F-6 (17 CFR 239.36). (d) Definitions. For purposes of this section: (1) SEC means the Securities...-QSB, or Form 20-F (17 CFR 249.310, 249.308a, 249.310b, 249.308b, or 249.220f) filed with the... outstanding shares subsequently reported by the issuer on a Form 8-K (17 CFR 249.308). (8) Preceding 6...

  8. Avaliação nutricional da casca de soja integral ou moída, ensilada ou não, para suínos em fase de crescimento - DOI: 10.4025/actascianimsci.v29i1.249 Nutritional evaluation of whole or grinder soybean hull, ensilaged or not, for growing pigs - DOI: 10.4025/actascianimsci.v29i1.249

    OpenAIRE

    Cleber Rogério Ribeiro; Diovani Paiano; Ivan Moreira; Arlei Rodrigues Bonet Quadros; Nikychiella Silvestrim; Antônio Cláudio Furlan

    2007-01-01

    Foi conduzido um experimento com 11 suínos híbridos, machos castrados, com peso vivo de 41,42 ± 0,99 kg. Os animais foram alojados individualmente em gaiolas de metabolismo e distribuídos em um delineamento experimental inteiramente casualizado, com parcelas subdivididas, com quatro tratamentos em esquema fatorial 2 x 2 (moagem x ensilagem). Os alimentos avaliados foram: a casca de soja (CS) integral (CSI), CS moída (CSM), silagem de CSI (SCSI) e silagem de CSM (SCSM), que substituíram, com b...

  9. Composition containing transuranic elements for use in the homeopathic treatment of aids

    Energy Technology Data Exchange (ETDEWEB)

    Lustig, D.

    1996-04-18

    A homeopathic remedy consisting of a composition containing one or more transuranic elements, particularly plutonium, for preventing and treating acquired immunodeficiency syndrome (AIDS) in humans, as well as seropositivity for human immunodeficiency virus (HIV). Said composition is characterized in that it uses any chemical or isotopic form of one or more transuranic elements (neptunium, plutonium, americium, curium, berkelium, californium or einsteinium), particularly plutonium, said form being diluted and dynamized according to conventional homeopathic methods, particularly the so-called Hahnemann and Korsakov methods, and provided preferably but not exclusively in the form of lactose and/or saccharose globules or granules impregnated with the active principle of said composition. (author).

  10. TOWARD AN IMPROVED UNDERSTANDING OF STRUCTURE AND MAGNETISM IN NEPTUNIUM AND PLUTONIUM PHOSPHONATES AND SULFONATES

    Energy Technology Data Exchange (ETDEWEB)

    Albrecht-Schmitt, Thomas

    2012-03-01

    This grant supported the exploratory synthesis of new actinide materials with all of the actinides from thorium to californium with the exceptions of protactinium and berkelium. We developed detailed structure-property relationships that allowed for the identification of novel materials with selective ion-exchange, selective oxidation, and long-range magnetic ordering. We found novel bonding motifs and identified periodic trends across the actinide series. We identified structural building units that would lead to desired structural features and novel topologies. We also characterized many different spectroscopic trends across the actinide series. The grant support the preparation of approximately 1200 new compounds all of which were structurally characterized.

  11. Detection of rare earth elements in Powder River Basin sub-bituminous coal ash using laser-induced breakdown spectroscopy (LIBS)

    Energy Technology Data Exchange (ETDEWEB)

    Tran, Phuoc [National Energy Technology Lab. (NETL), Pittsburgh, PA, (United State; Mcintyre, Dustin [National Energy Technology Lab. (NETL), Pittsburgh, PA, (United State

    2015-10-01

    We reported our preliminary results on the use of laser-induced breakdown spectroscopy to analyze the rare earth elements contained in ash samples from Powder River Basin sub-bituminous coal (PRB-coal). We have identified many elements in the lanthanide series (cerium, europium, holmium, lanthanum, lutetium, praseodymium, promethium, samarium, terbium, ytterbium) and some elements in the actinide series (actinium, thorium, uranium, plutonium, berkelium, californium) in the ash samples. In addition, various metals were also seen to present in the ash samples

  12. Composition containing transuranic elements for use in the homeopathic treatment of aids

    International Nuclear Information System (INIS)

    A homeopathic remedy consisting of a composition containing one or more transuranic elements, particularly plutonium, for preventing and treating acquired immunodeficiency syndrome (AIDS) in humans, as well as seropositivity for human immunodeficiency virus (HIV). Said composition is characterized in that it uses any chemical or isotopic form of one or more transuranic elements (neptunium, plutonium, americium, curium, berkelium, californium or einsteinium), particularly plutonium, said form being diluted and dynamized according to conventional homeopathic methods, particularly the so-called Hahnemann and Korsakov methods, and provided preferably but not exclusively in the form of lactose and/or saccharose globules or granules impregnated with the active principle of said composition. (author)

  13. PROCEEDINGS OF THE SYMPOSIUM COMMEMORATING THE 25th ANNIVERSARY OF ELEMENTS 97 and 98 HELD ON JAN. 20, 1975

    Energy Technology Data Exchange (ETDEWEB)

    Seaborg, Glenn T.; Street Jr., Kenneth; Thompson, Stanley G.; Ghiorso, Albert

    1976-07-01

    This volume includes the talks given on January 20, 1975, at a symposium in Berkeley on the occasion of the celebration of the 25th anniversary of the discovery of berkelium and californium. Talks were given at this symposium by the four people involved in the discovery of these elements and by a number of people who have made significant contributions in the intervening years to the investigation of their nuclear and chemical properties. The papers are being published here, without editing, in the form in which they were submitted by the authors in the months following the anniversary symposium, and they reflect rather faithfully the remarks made on that occasion.

  14. Roman for unge - og deres voksne - fra Nick Hornby

    DEFF Research Database (Denmark)

    Haarder, Jon Helt

    2007-01-01

    Nick Hornby: SLAM. Oversat fra engelsk. af Jan Hansen. 280 sider, 249 kr. Lindhardt og Ringhof. Fire stjerner Udgivelsesdato: 071207......Nick Hornby: SLAM. Oversat fra engelsk. af Jan Hansen. 280 sider, 249 kr. Lindhardt og Ringhof. Fire stjerner Udgivelsesdato: 071207...

  15. Gclust Server: 172174 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 172174 TET_249.m00042 Cluster Sequences - 21 hypothetical protein chr_0_8254705_249...; no annotation 1 1.00e-99 0.0 11.11 0.0 0.0 0.0 0.0 Show 172174 Cluster ID 172174 Sequence ID TET_249.m0004

  16. Dietary exposure to benzoates (E210-E213), parabens (E214-E219), nitrites (E249-E250), nitrates (E251-E252), BHA (E320), BHT (E321) and aspartame (E951) in children less than 3 years old in France.

    Science.gov (United States)

    Mancini, F R; Paul, D; Gauvreau, J; Volatier, J L; Vin, K; Hulin, M

    2015-01-01

    This study aimed to estimate the exposure to seven additives (benzoates, parabens, nitrites, nitrates, BHA, BHT and aspartame) in children aged less than 3 years old in France. A conservative approach, combining individual consumption data with maximum permitted levels, was carried out for all the additives. More refined estimates using occurrence data obtained from products' labels (collected by the French Observatory of Food Quality) were conducted for those additives that exceeded the acceptable daily intake (ADI). Information on additives' occurrence was obtained from the food labels. When the ADI was still exceeded, the exposure estimate was further refined using measured concentration data, if available. When using the maximum permitted level (MPL), the ADI was exceeded for benzoates (1.94 mg kg(-1) bw day(-1)), nitrites (0.09 mg kg(-1) bw day(-1)) and BHA (0.39 mg kg(-1) bw day(-1)) in 25%, 54% and 20% of the entire study population respectively. The main food contributors identified with this approach were current foods as these additives are not authorised in specific infant food: vegetable soups and broths for both benzoates and BHA, delicatessen and meat for nitrites. The exposure estimate was significantly reduced when using occurrence data, but in the upper-bound scenario the ADI was still exceeded significantly by the age group 13-36 months for benzoates (2%) and BHA (1%), and by the age group 7-12 months (16%) and 13-36 months (58%) for nitrites. Measured concentration data were available exclusively for nitrites and the results obtained using these data showed that the nitrites' intake was below the ADI for all the population considered in this study. These results suggest that refinement of exposure, based on the assessment of food levels, is needed to estimate the exposure of children to BHA and benzoates for which the risk of exceeding the ADI cannot be excluded when using occurrence data. PMID:25686474

  17. Dietary exposure to benzoates (E210-E213), parabens (E214-E219), nitrites (E249-E250), nitrates (E251-E252), BHA (E320), BHT (E321) and aspartame (E951) in children less than 3 years old in France.

    Science.gov (United States)

    Mancini, F R; Paul, D; Gauvreau, J; Volatier, J L; Vin, K; Hulin, M

    2015-01-01

    This study aimed to estimate the exposure to seven additives (benzoates, parabens, nitrites, nitrates, BHA, BHT and aspartame) in children aged less than 3 years old in France. A conservative approach, combining individual consumption data with maximum permitted levels, was carried out for all the additives. More refined estimates using occurrence data obtained from products' labels (collected by the French Observatory of Food Quality) were conducted for those additives that exceeded the acceptable daily intake (ADI). Information on additives' occurrence was obtained from the food labels. When the ADI was still exceeded, the exposure estimate was further refined using measured concentration data, if available. When using the maximum permitted level (MPL), the ADI was exceeded for benzoates (1.94 mg kg(-1) bw day(-1)), nitrites (0.09 mg kg(-1) bw day(-1)) and BHA (0.39 mg kg(-1) bw day(-1)) in 25%, 54% and 20% of the entire study population respectively. The main food contributors identified with this approach were current foods as these additives are not authorised in specific infant food: vegetable soups and broths for both benzoates and BHA, delicatessen and meat for nitrites. The exposure estimate was significantly reduced when using occurrence data, but in the upper-bound scenario the ADI was still exceeded significantly by the age group 13-36 months for benzoates (2%) and BHA (1%), and by the age group 7-12 months (16%) and 13-36 months (58%) for nitrites. Measured concentration data were available exclusively for nitrites and the results obtained using these data showed that the nitrites' intake was below the ADI for all the population considered in this study. These results suggest that refinement of exposure, based on the assessment of food levels, is needed to estimate the exposure of children to BHA and benzoates for which the risk of exceeding the ADI cannot be excluded when using occurrence data.

  18. Struggling to Improve Our Understanding of Nursing Student Information Needs. A review of: Gannon‐Leary, Pat, Graham Walton, Raffik Cader, Julie Derbyshire, and Ann Smith. “Use of Evidence by Nursing Students: An Interdisciplinary Study.” Library & Information Science Research 28.2 (Mar. 2006: 249‐64.

    Directory of Open Access Journals (Sweden)

    Michael Corkett

    2007-06-01

    Full Text Available Objective – To identify the sources used by student nurses when undertaking a health needs analysis of particular client groups, and to determine students’ ease in accessing source materials.Design – Case series, incorporating citation analysis and focus groups.Setting – Honours Nursing Studies program (Adult Branch, Northumbria University, Newcastle upon Tyne, United Kingdom.Subjects – Citation analysis: 40 students undertaking health needs analysis assignment. Focus groups: 2 groups of 8 students.Methods – Subjects for the citation analysis were not randomly selected. Citation analysis was performed and references tabulated using a previously piloted proforma. Distribution of references between sources was measured using quantitative analysis. Focus groups consisted of self selecting volunteers from the student cohort undertaking the assignment. Issues of potential bias/coercion relating to research team members being group participant tutors were addressed. Results were analysed through the categorisation of key themes.Main results – The mean number of sources cited per assignment was 16. More than half( 56% of the sources were published after 1999. Twenty‐nine percent of citations were published between 1996 and 1999, and 12% between 1990 and 1995. Only small percentages were published in the 1980s (2% and 1970s (1%. Journals (37% formed the largest body of references, followed by books at 27%. UK government publications accounted for 14% of total references; Web based resources totalled 12%. Students acknowledged the importance of supporting assignments with references. Government publications were recognised as high quality pieces of evidence. Difficulty was experienced extrapolating evidence from different care settings and moving outside of usual parameters. Students indicated that statistical data was hard to find. Those without home Internet facilities had greater difficulty in accessing information than students with such facilities. Support from information professionals was received, but quality was variable.Conclusion – Doubts exist as to whether opportunities for student learning to inform educators are being fully exploited. Upon completion of assignments students are arguably in a better position to debate subjects more deeply and so advance understanding. Potential for peer group development may be lost. Collaboration between nursing academics and information professionals offers potential for nursing students and health professionals to advance their exploitation and evaluation of information resources.

  19. Dicty_cDB: [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available VF (Link to library) VFC249 (Link to dictyBase) - - - Contig-U16272-1 VFC249P (Link... to Original site) VFC249F 500 VFC249Z 585 VFC249P 1085 - - Show VFC249 Library VF (Link to library) Clone ID VFC249 (Link to dict...yBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Contig-U16272-1 Original site URL http://dict...te 2004.12.25 Homology vs DNA Score E Sequences producing significant alignments: (bits) Value N L08391 |L08391.1 Dict...0.00 mNt: 0.00 m3a: 0.00 m3b: 0.00 m_ : 1.00 88.0 %: cytoplasmic 8.0 %: mitochondrial 4.0 %: nuclear >> predict

  20. An atomic beam source for actinide elements: concept and realization

    International Nuclear Information System (INIS)

    For ultratrace analysis of actinide elements and studies of their atomic properties with resonance ionization mass spectroscopy (RIMS), efficient and stable sources of actinide atomic beams are required. The thermodynamics and kinetics of the evaporation of actinide elements and oxides from a variety of metals were considered, including diffusion, desorption, and associative desorption. On this basis various sandwich-type filaments were studied. The most promising system was found to consist of tantalum as the backing material, an electrolytically deposited actinide hydroxide as the source of the element, and a titanium covering layer for its reduction to the metal. Such sandwich sources were experimentally proven to be well suited for the production of atomic beams of plutonium, curium, berkelium and californium at relatively low operating temperatures and with high and reproducible yields. (orig.)

  1. Nuclear fission and the transuranium elements

    Energy Technology Data Exchange (ETDEWEB)

    Seaborg, G.T.

    1989-02-01

    Many of the transuranium elements are produced and isolated in large quantities through the use of neutrons furnished by nuclear fission reactions: plutonium (atomic number 94) in ton quantities; neptunium (93), americium (95), and curium (96) in kilogram quantities; berkelium (97) in 100 milligram quantities; californium (98) in gram quantities; and einsteinium (99) in milligram quantities. Transuranium isotopes have found many practical applications---as nuclear fuel for the large-scale generation of electricity, as compact, long-lived power sources for use in space exploration, as means for diagnosis and treatment in the medical area, and as tools in numerous industrial processes. Of particular interest is the unusual chemistry and impact of these heaviest elements on the periodic table. This account will feature these aspects. 9 refs., 5 figs.

  2. Production of transuranium elements

    International Nuclear Information System (INIS)

    The Radiochemical Engineering Development Center (REDC) has the programmatic responsibility for the Department of Energy's Transuranium Element Program. Principle elements from the program are einsteinium, berkelium, and fermium. Targets containing curium oxide mixed with aluminum powder are fabricated by the REDC and irradiated in the Oak Ridge National Laboratory (ORNL) High Flux Isotope Reactor. Following an irradiation period of 6-12 months, targets are returned to the REDC for chemical processing. Processing operations consists of aluminum dejacketing in a caustic-nitrate solution, filtration, acid dissolution, solvent extraction, anion exchange, and finally a cation exchange to recover the actinides. The processing operations take place in heavily shielded hot cell facilities and all operations are carried out remotely. The chemistry for the separations has been well established over the 26-yr. operating life of the facility

  3. 17 CFR 229.1101 - (Item 1101) Definitions.

    Science.gov (United States)

    2010-04-01

    ... type of assets comprising the pool and the programs under which the loans were originated; (3... additional assets to the pool that backs such securities in connection with future issuances of asset-backed... either Item 6.05 of Form 8-K (17 CFR 249.308) or in a Form 10-D (17 CFR 249.312) pursuant to Item...

  4. 75 FR 65442 - Disclosure for Asset-Backed Securities Required by Section 943 of the Dodd-Frank Wall Street...

    Science.gov (United States)

    2010-10-25

    ... Register of October 13, 2010, in FR Doc. 2010-25361, the reference ``249.1300'' is corrected to read ``249... Securities Required by Section 943 of the Dodd-Frank Wall Street Reform and Consumer Protection Act AGENCY...-Backed Securities Required by Section 943 of the Dodd-Frank Wall Street Reform and Consumer...

  5. 17 CFR 240.19b-4 - Filings with respect to proposed rule changes by self-regulatory organizations.

    Science.gov (United States)

    2010-04-01

    ... organizations. Preliminary Note: A self-regulatory organization also must refer to Form 19b-4 (17 CFR 249.819... paragraph (e), a self-regulatory organization shall submit Form 19b-4(e) (17 CFR 249.820) to the Commission... proposed rule changes by a self-regulatory organization submitted on Form 19b-4 (17 CFR...

  6. Review of: Islam, Migration and Integration: The Age of Securitization

    DEFF Research Database (Denmark)

    Vinding, Niels Valdemar

    2010-01-01

    Islam, Migration and Integration: The Age of Securitization. By Ayhan Kaya. (Migration, Minorities and Citizenship). Houndmills, Basingstoke: Palgrave Macmillan, 2009. Pp. xiv+249. Hbk 978-0-230-51679-3. £55.......Islam, Migration and Integration: The Age of Securitization. By Ayhan Kaya. (Migration, Minorities and Citizenship). Houndmills, Basingstoke: Palgrave Macmillan, 2009. Pp. xiv+249. Hbk 978-0-230-51679-3. £55....

  7. Significance of mangrove swamps for aquaculture

    Digital Repository Service at National Institute of Oceanography (India)

    Wafar, S.; Untawale, A.G.

    stream_size 9 stream_content_type text/plain stream_name I.O_21_Century_Linkage_Networking_1998_249.pdf.txt stream_source_info I.O_21_Century_Linkage_Networking_1998_249.pdf.txt Content-Encoding ISO-8859-1 Content-Type text...

  8. Nuclear Chemistry Institute, Mainz University. Annual Report 1995

    International Nuclear Information System (INIS)

    The annual report of the Institut fuer Kernchemie addresses inter alia three main research activities. The first belongs to the area of basic research, covering studies in the fields of nuclear fission, chemistry of the super-heavy elements and of heavy-ion reactions extending from the Coulomb barrier to relativistic energies, and nuclear astrophysics in connection with the ''r process''. By means of laser technology, high-precision data could be measured of the ionization energies of berkelium and californium. Studies of atomic clusters in the vacuum of an ionization trap revealed interesting aspects. The second major activity was devoted to the analysis of environmental media, applying inter alia neutron activation analysis and resonance ionization mass spectroscopy (RIMS). The third activity resulted in the development of novel processes, or the enhancement of existing processes or methods, for applications in basic research work and in environmental analytics. Another item of interest is the summarizing report on the operation of the TRIGA research reactor. (orig./SR)

  9. Characterization of a Viking Blade Fabricated by Traditional Forging Techniques

    Science.gov (United States)

    Vo, H.; Frazer, D.; Bailey, N.; Traylor, R.; Austin, J.; Pringle, J.; Bickel, J.; Connick, R.; Connick, W.; Hosemann, P.

    2016-09-01

    A team of students from the University of California, Berkeley, participated in a blade-smithing competition hosted by the Minerals, Metals, and Materials Society at the TMS 2015 144th annual meeting and exhibition. Motivated by ancient forging methods, the UC Berkeley team chose to fabricate our blade from historical smithing techniques utilizing naturally-occurring deposits of iron ore. This approach resulted in receiving the "Best Example of a Traditional Blade Process/Ore Smelting Technique" award for our blade named "Berkelium." First, iron-enriched sand was collected from local beaches. Magnetite (Fe3O4) was then extracted from the sand and smelted into individual high- and low-carbon steel ingots. Layers of high- and low-carbon steels were forge-welded together, predominantly by hand, to form a composite material. Optical microscopy, energy dispersive spectroscopy, and Vickers hardness mechanical testing were conducted at different stages throughout the blade-making process to evaluate the microstructure and hardness evolution during formation. It was found that the pre-heat-treated blade microstructure was composed of ferrite and pearlite, and contained many nonmetallic inclusions. A final heat treatment was performed, which caused the average hardness of the blade edge to increase by more than a factor of two, indicating a martensitic transformation.

  10. Paul Scherrer Institute Scientific Report 1999. Volume I: Particles and Matter

    International Nuclear Information System (INIS)

    Although originally planned for fundamental research in nuclear physics, the particle beams of pions, muons, protons and neutrons are now used in a large variety of disciplines in both natural science and medicine. The beams at PSI have the world's highest intensities and therefore allow certain experiments to be performed, which would not be possible elsewhere. The highlight of research this year was the first-ever determination of the chemical properties of the superheavy element 107 Bohrium. This was undertaken, by an international team led by H. Gaeggeler of PSI's Laboratory for Radiochemistry. Bohrium was produced by bombarding a Berkelium target with Neon ions from the Injector I cyclotron and six atoms were detected after having passed through an online gas chromatography device. At the Laboratory for Particle Physics the focus has shifted from nuclear physics to elementary particle physics with about a fifty-fifty split between investigations of rare processes or particle decays using the high intensity muon, pion and recently also polarized neutron beams of PSI, and research at the highest energy frontier at CERN (Geneva) and DESY (Hamburg). Important space instrumentation has been contributed by the Laboratory for Astrophysics to the European Space Agency and NASA satellite programmes. The Laboratory for Micro and Nanotechnology continued to focus on research into molecular nanotechnology and SiGeC nanostructures, the latter with the aim of producing silicon based optoelectronics. Progress in 1999 in these topical areas is described in this report. A list of scientific publications in 1999 is also provided

  11. Disease: H00156 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available osity. Clin Exp Nephrol 11:174-9 (2007) PMID:15630634 Smelt AH, de Beer F Apolipoprotein E and familial dysbetalipoproteinemia: clini...cal, biochemical, and genetic aspects. Semin Vasc Med 4:249-57 (2004) ...

  12. Gclust Server: 76570 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 76570 HSA_8923040 Cluster Sequences Related Sequences(249) 580 NP_060102.1 collaborates/cooper...tion NP_060102.1 collaborates/cooperates with ARF (alternate reading frame) protein ; no annotation Number o

  13. Data of evolutionary structure change: 1CFVH-1QLRB [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1CFVH-1QLRB 1CFV 1QLR H B QVQLQESGGGLVNLGGSMTLSCVASGFTFNTYYMSWVRQ...------------------------------------------------VSS------------ EVQLQQWGAGLLKPSETLSLTCAVYGGSFSD...Y CA 249 1QLR B... 1QLRB CARPPHDTSGHY EEE 1 1QLR B 1QLR

  14. 76 FR 51998 - Announcement of Funding Awards for the Service Coordinators in Multifamily Housing Fiscal Year 2009

    Science.gov (United States)

    2011-08-19

    ... Recipient: Catholic Charities of St. Paul and Minneapolis Property Name: Mary Hall SRO Occupancy Program... City: Richmond Assisted Units: 249 Amount: $194,416 Recipient: Elm Manor Homes, Inc. Property Name:...

  15. Disease: H00905 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available Bockenhauer D, Kleta R Aminoacidurias: Clinical and molecular aspects. Kidney In...mmalian intestinal and renal epithelia. Physiol Rev 88:249-86 (2008) PMID:18200002 (description) Camargo SM,

  16. 76 FR 1492 - Notice of Actions Taken at December 16, 2010, Meeting

    Science.gov (United States)

    2011-01-10

    ...: Hughesville-Wolf Township Joint Municipal Authority. Project Facility: Wastewater Treatment Plant, Wolf Township, Lycoming County, Pa. Withdrawal of treated wastewater effluent of up to 0.249 mgd. 6....

  17. EST Table: BB985913 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available ar to putative lysosomal glucocerebrosidase [Tribolium castaneum] 10/08/28 30 %/249 aa FBpp0129766|DereGG112...EDICTED: similar to putative lysosomal glucocerebrosidase [Tribolium castaneum] BB985877 MSV3 ...

  18. Temperature, salinity, oxygen, nutrients and productivity profile data from THOMAS G. THOMPSON Cruise 001, 19651014 to 19651207 in the Caribbean Sea and the northeastern tropical Pacific Ocean (NODC Accession 7100507)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This accession contains a copy of University of Washington Department of Oceanography Technical Report No. 249, Physical, chemical, and productivity data from a...

  19. 1983 walrus harvest, health, and welfare study at Gambell, Alaska: Progress report

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The total documented harvest during the period of observation in 1983 was 642 walruses. This included 249 adult males (38.8%), 203 adult females (31.6%), and 190...

  20. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... count__/__total__ Find out why Close Pediatric Palliative Care: A Personal Story NINRnews Subscribe Subscribed Unsubscribe 249 ... and her family. The story demonstrates how palliative care can positively influence a patient's and family's experience ...

  1. Gene : CBRC-MDOM-11-0012 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available ica protamine 1 (PRM1), mRNA /cds=p(73,249) /gb=NM_001032967 /gi=74136486 /ug=Mdm.246 /len=400 0.004 29% MEGKGKKKRKKERKKERKKERKKERK...KERKKERKKERKKERKKERKKERKKERKKERKKERKKERKKERERERKKERKKVRKRERKKERKREREKERKKERKKERK...RERKREREKERKREREKERKKEREKERKKERKKERKKERKKERKKERKKERKKERKKERKKERKKERKKERKKERKKEKKEKRRREMKSQRGEVLKVVQRRRARI ...

  2. Gene : CBRC-MDOM-08-0074 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available ca protamine 1 (PRM1), mRNA /cds=p(73,249) /gb=NM_001032967 /gi=74136486 /ug=Mdm.246 /len=400 2e-04 25% MIFRINSKIESKNFLRKERKKERK...KERRKKERRKKKKERKKERRKKKERRRRKKEEREREREREREPVEKEREKKERKRESLRERKNERKKERKKERKKDRQKERKKERK...KERKKERKKERKKERKKERKKERKKEREKEREREREKERKREREKERKKERKKERKKERKKERKKERKKERKKESERKGEKGRETHEEREKQRKKKKKGSKKKK ...

  3. Gene : CBRC-MDOM-04-0419 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available ca protamine 1 (PRM1), mRNA /cds=p(73,249) /gb=NM_001032967 /gi=74136486 /ug=Mdm.246 /len=400 0.002 24% MRFEPRSSGSRASALSTINVLRKKERK...KERKKERKKERKKERKKERKKERKKERKKERKKERKKERKEERKKERKKERKKERKKERKEERKKGRKKERKKERK...KGRKEGRKEERKEERKKGRKEERKKGRKEERKKERKKERKKERKKERKKERKKERKKERKKERKKERKKERKKERKKERVRSGRDLRT ...

  4. Gene : CBRC-MDOM-01-0367 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available ca protamine 1 (PRM1), mRNA /cds=p(73,249) /gb=NM_001032967 /gi=74136486 /ug=Mdm.246 /len=400 0.002 40% MEGKGEERKRERKKERKREREKERKKERK...KERKKERKKERKKERKKERKKERKKERKKERKREREKERKREREKERKKERKKERKKERERKKERKRERQERKKERKKERK...KERKKERKKERKKERKKERKKERKKERKKGRKEGRKEGRKEGRKEERKKERKKERKKERKKERKKERKKERKKERKEGRKEGR

  5. Gene : CBRC-MDOM-03-0097 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available mestica protamine 1 (PRM1), mRNA /cds=p(73,249) /gb=NM_001032967 /gi=74136486 /ug=Mdm.246 /len=400 3e-04 31% MCRKKEKKKERKKERKKERKKERK...KERERKRERERKKERERERERKKERKKERKKERKKERKKERKKERERERERRRERKREREKEKERKREREKERK...REREKERKREREKERKREREKERKREREKERKKERKKERKKERKKERKKERKKERKKERKKERKGGRKEGRKEGRKEGRKEGRKEGERKGGRRRNRKGRGVEEGRER ...

  6. Gene : CBRC-MDOM-02-0481 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available his domestica protamine 1 (PRM1), mRNA /cds=p(73,249) /gb=NM_001032967 /gi=74136486 /ug=Mdm.246 /len=400 0.17 37% MERVEEREEKRREEKRRE...EKRREEKRREEKRREEKRREEKRREEKRREEKRREEKRREEKRREEKRREEKRRGREEDREEKRREEKRREEKRRE...EKREDKRRQERREEKRREEKRREEKRREEKRREEKRREEKREKKREEKRREKKKEKRREEKRREEKRREEKRREEKRREEKRREEKRREEKRRGREEDREEKRREEKRRE...EKRREKTREDKREEKRREEKRREEKRREEKRREEKRRERRKEKRREEKKRKRREEKRREEKRREEKRREEKRREEKRREEKRREEKRREKRSNAQLRVAKT ...

  7. Fire exposed facades: Numerical modelling of the LEPIR2 testing facility

    OpenAIRE

    Dréan Virginie; Schillinger Renaud; Auguin Gildas

    2016-01-01

    LEPIR2 testing facility is aimed to evaluate the fire behaviour of construction solutions implemented on facade according with the experimental evaluation required by the French Technical Specification 249 (IT249) of the safety regulation. It aims to limit the risks of fire spreading by facades to upper levels. This facility involves a wood crib fire in the lower compartment of a full scale two levels high structure. Flames are coming outside from the compartment through windows openings and ...

  8. Die Wirksamkeit der stereotaktischen Radiochirurgie und der fraktionierten stereotaktischen Radiotherapie bei Vestibularisschwannomen (Akustikusneurinomen)

    OpenAIRE

    Müllner, Stefanie Barbara

    2015-01-01

    Background: Vestibular schwannoma are benigne, slow growing tumors susceptible to various treatment regimes. Methods: From 1998 to 2008 249 patients had treatment for vestibular schwannoma using a linear accelerator. We investigated change in tumor volume as well as change in tumor specific clinical symptomsfor example like facial nerve dysfunction, tinnitus, vertigo or hearing loss. Results: Of these 249 patients 190 patients (46,3% male, 53% female, median age 59y) underwent stereot...

  9. Recension: Efectos personales del divorcio respecto de los hijos – Review: Personal Effects of Divorce in Relation to Children

    OpenAIRE

    Teresa Dupla Marin

    2013-01-01

    Recension: Carmen López‐Rendo Rodríguez, Efectos personales del divorcio respecto de los hijos, De Roma al Codigo civil español, RIDROM (online) 9, 2012, Pág. 249–270Review: Carmen López‐Rendo Rodríguez, Personal Effects of Divorce in Relation to Children, from Classical Rome to the Spanish Civil Code, RIDROM (online) 9, 2012, pp. 249–270

  10. Recension: Efectos personales del divorcio respecto de los hijos – Review: Personal Effects of Divorce in Relation to Children

    Directory of Open Access Journals (Sweden)

    Teresa Dupla Marin

    2013-05-01

    Full Text Available Recension: Carmen López‐Rendo Rodríguez, Efectos personales del divorcio respecto de los hijos, De Roma al Codigo civil español, RIDROM (online 9, 2012, Pág. 249–270Review: Carmen López‐Rendo Rodríguez, Personal Effects of Divorce in Relation to Children, from Classical Rome to the Spanish Civil Code, RIDROM (online 9, 2012, pp. 249–270

  11. 17 CFR 240.3a55-1 - Method for determining market capitalization and dollar value of average daily trading volume...

    Science.gov (United States)

    2010-04-01

    ... market capitalization and dollar value of average daily trading volume; application of the definition of... Securities Act of 1933 (15 U.S.C. 77a et seq.) on Form F-6 (17 CFR 239.36). (d) Definitions. For purposes of... recent Form 10-K, Form 10-Q, Form 10-KSB, Form 10-QSB, or Form 20-F (17 CFR 249.310, 249.308a,...

  12. 17 CFR 270.30a-3 - Controls and procedures.

    Science.gov (United States)

    2010-04-01

    ... and procedures, within the 90-day period prior to the filing date of each report on Form N-CSR (§§ 249... to be disclosed by the investment company on Form N-CSR (§§ 249.331 and 274.128 of this chapter) and... disclosed by an investment company in the reports that it files or submits on Form N-CSR and Form N-Q...

  13. 17 CFR 240.10b-18 - Purchases of certain equity securities by the issuer and others.

    Science.gov (United States)

    2010-04-01

    ... report their repurchasing activity as required by Item 8 of Form N-CSR (17 CFR 249.331; 17 CFR 274.128... report their repurchasing activity as required by Item 703 of Regulations S-K and S-B (17 CFR 229.703 and 228.703) and Item 15(e) of Form 20-F (17 CFR 249.220f) (regarding foreign private issuers), and...

  14. Minor Actinide Burning in Thermal Reactors. A Report by the Working Party on Scientific Issues of Reactor Systems

    International Nuclear Information System (INIS)

    The actinides (or actinoids) are those elements in the periodic table from actinium upwards. Uranium (U) and plutonium (Pu) are two of the principal elements in nuclear fuel that could be classed as major actinides. The minor actinides are normally taken to be the triad of neptunium (Np), americium (Am) and curium (Cm). The combined masses of the remaining actinides (i.e. actinium, thorium, protactinium, berkelium, californium, einsteinium and fermium) are small enough to be regarded as very minor trace contaminants in nuclear fuel. Those elements above uranium in the periodic table are known collectively as the transuranics (TRUs). The operation of a nuclear reactor produces large quantities of irradiated fuel (sometimes referred to as spent fuel), which is either stored prior to eventual deep geological disposal or reprocessed to enable actinide recycling. A modern light water reactor (LWR) of 1 GWe capacity will typically discharge about 20-25 tonnes of irradiated fuel per year of operation. About 93-94% of the mass of uranium oxide irradiated fuel is comprised of uranium (mostly 238U), with about 4-5% fission products and ∼1% plutonium. About 0.1-0.2% of the mass is comprised of neptunium, americium and curium. These latter elements accumulate in nuclear fuel because of neutron captures, and they contribute significantly to decay heat loading and neutron output, as well as to the overall radio-toxic hazard of spent fuel. Although the total minor actinide mass is relatively small - approximately 20-25 kg per year from a 1 GWe LWR - it has a disproportionate impact on spent fuel disposal, and thus the longstanding interest in transmuting these actinides either by fission (to fission products) or neutron capture in order to reduce their impact on the back end of the fuel cycle. The combined masses of the trace actinides actinium, thorium, protactinium, berkelium and californium in irradiated LWR fuel are only about 2 parts per billion, which is far too low for

  15. Pseudomonas cepacia adherence to respiratory epithelial cells is enhanced by Pseudomonas aeruginosa

    International Nuclear Information System (INIS)

    Pseudomonas aeruginosa and Pseudomonas cepacia are both opportunistic pathogens of patients with cystic fibrosis. The binding characteristics of these two species were compared to determine if they use similar mechanisms to adhere to respiratory epithelial cells. P. cepacia 249 was shown to be piliated, but there was no detectable homology between P. aeruginosa pilin gene probes and P. cepacia genomic DNA. P. cepacia and P. aeruginosa did not appear to compete for epithelial receptors. In the presence of purified P. aeruginosa pili, the adherence of 35S-labeled strain 249 to respiratory epithelial monolayers was unaffected, while that of P. aeruginosa PAO1 was decreased by 55%. The binding of P. cepacia 249 and 715j was increased by 2.4-fold and 1.5-fold, respectively, in the presence of an equal inoculum of PAO1. Interbacterial agglutination contributed to the increased adherence of P. cepacia, as the binding of 249 was increased twofold in the presence of irradiated PAO1. PAO1 exoproducts had a marked effect in enhancing the ability of the P. cepacia strains to adhere to the epithelial monolayers. A PAO1 supernatant increased the binding of 249 by eightfold and that of 715j by fourfold. Thus, there appears to be a synergistic relationship between P. aeruginosa and P. cepacia in which PAO1 exoproducts modify the epithelial cell surface, exposing receptors and facilitating increased P. cepacia attachment

  16. Paul Scherrer Institute Scientific Report 1999. Volume I: Particles and Matter

    Energy Technology Data Exchange (ETDEWEB)

    Gobrecht, J.; Gaeggeler, H.; Herlach, D.; Junker, K.; Kettle, P.-R.; Kubik, P.; Zehnder, A. [eds.

    2000-07-01

    lthough originally planned for fundamental research in nuclear physics, the particle beams of pions, muons, protons and neutrons are now used in a large variety of disciplines in both natural science and medicine. The beams at PSI have the world's highest intensities and therefore allow certain experiments to be performed, which would not be possible elsewhere. The highlight of research this year was the first-ever determination of the chemical properties of the superheavy element {sup 107} Bohrium. This was undertaken, by an international team led by H. Gaeggeler of PSI's Laboratory for Radiochemistry. Bohrium was produced by bombarding a Berkelium target with Neon ions from the Injector I cyclotron and six atoms were detected after having passed through an online gas chromatography device. At the Laboratory for Particle Physics the focus has shifted from nuclear physics to elementary particle physics with about a fifty-fifty split between investigations of rare processes or particle decays using the high intensity muon, pion and recently also polarized neutron beams of PSI, and research at the highest energy frontier at CERN (Geneva) and DESY (Hamburg). Important space instrumentation has been contributed by the Laboratory for Astrophysics to the European Space Agency and NASA satellite programmes. The Laboratory for Micro and Nanotechnology continued to focus on research into molecular nanotechnology and SiGeC nanostructures, the latter with the aim of producing silicon based optoelectronics. Progress in 1999 in these topical areas is described in this report. A list of scientific publications in 1999 is also provided.

  17. Transuranium Processing Plant semiannual report of production, status, and plans for period ending December 31, 1975

    Energy Technology Data Exchange (ETDEWEB)

    King, L.J.; Bigelow, J.E.; Collins, E.D.

    1976-10-01

    Between July 1, 1975, and December 31, 1975, maintenance was conducted at TRU for a period of three months, 295 g of curium oxide (enough for approximately 26 HFIR targets) were prepared, 100 mg of high-purity /sup 248/Cm, were separated from /sup 252/Cf that had been purified during earlier periods, 11 HFIR targets were fabricated, and 28 product shipments were made. No changes were made in the chemical processing flowsheets normally used at TRU during this report period. However, three equipment racks were replaced (with two new racks) during this time. In Cubicle 6, the equipment replaced was that used to decontaminate the transplutonium elements from rare earth fission products and to separate curium from the heavier elements by means of the LiCl-based anion-exchange process. In Cubicle 5, the equipment used to separate the transcurium elements by high-pressure ion exchange and to purify berkelium by batch solvent extraction was replaced. Two neutron sources were fabricated, bringing the total fabricated to 79. One source that had been used in a completed project was returned to the TRU inventory and is available for reissue. Three sources, for which no further use was foreseen, were processed to isolate and recover the ingrown /sup 248/Cm and the residual /sup 252/Cf. Eight pellets, each containing 100 ..mu..g of high-purity /sup 248/Cm were prepared for irradiation in HFIR to study the production of /sup 250/Cm. The values currently being used for transuranium element decay data and for cross-section data in planning irradiation-processing cycles, calculating production forecasts, and assaying products are tabulated.

  18. Differential expression of carotenoid biosynthetic pathway genes in two contrasting tomato genotypes for lycopene content

    Indian Academy of Sciences (India)

    Shilpa Pandurangaiah; Kundapura V Ravishankar; Kodthalu S Shivashankar; Avverahally T Sadashiva; Kavitha Pillakenchappa; Sunil Kumar Narayanan

    2016-06-01

    Tomato (Solanum lycopersicum L.) is one of the model plants to study the carotenoid biosynthesis. In the present study, the fruit carotenoid content were quantified at different developmental stages for two contrasting genotypes viz. IIHR-249-1and IIHR-2866 by UPLC. Lycopene content was high in IIHR-249-1(19.45 mg/100g fresh weight) compared to IIHR-2866 ((1.88 mg/100g fresh weight) at the ripe stage. qPCR was performed for genes that are involved in the carotenoid biosynthetic pathway to study the difference in lycopene content in fruits of both the genotypes. The expression of Phytoene Synthase (PSY) increased by 36 fold and Phytoene desaturase (PDS) increased by 14fold from immature green stage to ripe stage in IIHR-249-1. The expression of Chloroplast lycopene β cyclase (LCY-B) and Chromoplast lycopene β cyclase (CYC-B) decreased gradually from the initial stage to the ripe stage in IIHR-249-1. IIHR 249-1 showed 3 and 1.8 fold decrease in gene expression for Chloroplast lycopene β cyclase ((LCY-B) and Chromoplast lycopene β cyclase (CYC-B) .The F2 hybrids derived from IIHR-249-1 and IIHR-2866 were analyzed at the ripe stage for lycopene content. The gene expression of Chloroplast lycopene β cyclase (LCY-B) and Chromoplast lycopene β cyclase (CYC-B) in high and low lycopene lines from F2 progenies also showed the decrease in transcript levels of both the genes in high lycopene F2 lines. We wish to suggest that the differential expression of Lycopene β -cyclases can be used in marker assisted breeding.

  19. 轻机枪为士兵减负

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

    战士打仗想得胜,除了勇敢和坚强外,武器还要轻巧好用。这不,一款新型轻机枪在美国诞生,它名叫“LSAT”轻机枪。它可真是轻啊,自重仅为4.27千克(相当于1桶食用油的重量),比有名的轻机枪M249还轻。M249重8千克。

  20. 新款PSP GO PSP-N1000正式发布

    Institute of Scientific and Technical Information of China (English)

    魏晓燕

    2009-01-01

    如图1所示,索尼终于在E3前发布了最新款的PSP掌上游戏机-全新的PSP GO掌上游戏机,型号为PSP—N1000。全新的PSP GO掌上游戏机在北美售价249.99美元,在欧洲售价249.99欧元,日本售价26800日元。如图2所示。

  1. PSP Go

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    索尼官方正式公布的消息,PSP新机型“PSP GO”(PSP-N1000),将于2009年10月1日在欧美和亚洲部分地区发售预定价格为249美元、249欧元,至于日版则将会延后一个月在日本发售也就是2009年的11月1日,预定发售价格为26800日元。

  2. Prompt neutron multiplicities for the transplutonium nuclides

    International Nuclear Information System (INIS)

    The direct determination of the average prompt neutron emission values is reviewed, and a method of comparing different sites of neutron emission multiplicity distribution values is described. Measured and recommended values are tabulated for these nuclides: 241Am, 242Am, 242Cm, 243Cm, 244Cm, 246Cm, 247Cm, 248Cm, 250Cm, 245Cm, 249Bk, 246Cf, 249Cf, 250Cf, 252Cf, 254Cf, 251Cf, 253Es, 254Es, 244Fm, 246Fm, 255Fm, 252No, 254Fm, 256Fm, 257Fm. 59 refs., 24 tabs

  3. The Influence of Body Weight on the Prevalence and Severity of Hidradenitis Suppurativa

    DEFF Research Database (Denmark)

    Kromann, Charles B; Ibler, Kristina S; Kristiansen, Viggo B;

    2014-01-01

    The prevalence of hidradenitis suppurativa (HS) has been estimated to be 1% of the population. Obesity is considered a co-morbidity, but the prevalence of HS in obese population is not known. A retrospective questionnaire was distributed to 383 patients over 2 years after bariatric surgery. Data...... on pre- and post-surgery HS symptoms and disease severity were studied. Disease severity was assessed by number of involved sites. General skin problems rated numerically on an anchored 1-10 scale. Valid responses were obtained from 249/383 (65%). A point prevalence of 18.1% (45/249) HS was found...

  4. The relationship between difficulties in psychological adjustment in young adulthood and exposure to bullying behaviour in childhood and adolescence

    OpenAIRE

    Kristina Sesar; Marijana Barišić; Maja Pandža; Arta Dodaj

    2012-01-01

    Objective. This study investigates the relationship between involvement in bullying in childhood and adolescence and psychological difficulties in young adulthood. Materials and method. A total of 249college students completed the Retrospective Bullying Questionnaireand Trauma Symptom Checklist. Results. The results showed significantdifferences in psychological adjustment among respondents whowere exposed to bullying compared to respondents who were not exposedto bullying. Those exposed to b...

  5. Human impact during the Bronze Age on the vegetation at Lago Lucone (northern Italy)

    NARCIS (Netherlands)

    Valsecchi, V.; Tinner, W.; Finsinger, W.; Ammann, B.

    2006-01-01

    Lake-sediment records were used to reconstruct human impact on the landscape around Lago Lucone (45°33′N, 10°29′E, 249 m a.s.l.), a former lake in the western amphitheatre system of the Lago di Garda. Presence of prehistoric human populations is attested by pile-dwelling settlements from the Early-M

  6. 17 CFR 232.104 - Unofficial PDF copies included in an electronic submission.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Unofficial PDF copies included... Filing Requirements § 232.104 Unofficial PDF copies included in an electronic submission. (a) An... (§ 249.101 of this chapter) or a Form D (§ 239.500 of this chapter), may include one unofficial PDF...

  7. Substance Use and Sexual Behaviors among Japanese Tourists, Students, and Temporary Workers in Honolulu, Hawaii

    Science.gov (United States)

    Nemoto, Tooru; Iwamoto, Mariko; Morris, Anne; Yokota, Fumihiko; Wada, Kiyoshi

    2007-01-01

    A total of 249 Japanese nationals--tourists (n = 107), students (n = 98), and temporary workers (n = 44)--were recruited at the targeted community venues in Honolulu, Hawaii, and completed a structured survey questionnaire. Reported lifetime sexually transmitted diseases, or STDs infection (10% male and 20% female participants), and HIV infection…

  8. Attitudes toward Physical Education and Class Preferences of Turkish Adolescents in Terms of School Gender Composition

    Science.gov (United States)

    Koca, Canan; Asci, F. Hulya; Demirhan, Giyasettin

    2005-01-01

    The purpose of this study was to examine attitudes toward physical education (PE and PE class preferences of high school Turkish students in terms of school gender composition; 213 girls and 249 boys from coeducational public schools, and 196 girls and 210 boys from single-sex vocational schools participated in the study. The Attitudes Toward…

  9. 75 FR 57385 - Internal Control Over Financial Reporting in Exchange Act Periodic Reports of Non-Accelerated Filers

    Science.gov (United States)

    2010-09-21

    ... COMMISSION 17 CFR Parts 210, 229, and 249 Internal Control Over Financial Reporting in Exchange Act Periodic... effectiveness of the company's internal control over financial reporting. See Release No. 33-8238 (June 5, 2003... audit report an assessment of the issuer's internal control over financial reporting. \\13\\ An...

  10. Psychometric Properties of the "Reminiscence Functions Scale" for the Portuguese Population: A Preliminary Report

    Science.gov (United States)

    Goncalves, Daniela C.; Guedes, Joana Martins; Fonseca, Antonio M.; Martin, Inacio

    2010-01-01

    The aim of the present study was to assess the psychometric properties of a version in Portuguese of the "Reminiscence Functions Scale." Total sample was composed of 628 participants aged between 18 and 92 years, divided into three groups according to their age (18-24 years, "n" = 249; 26-54 years, "n" = 174; 55 and older, "n" = 205). Results…

  11. A Novel Domain Cassette Identifies Plasmodium falciparum PfEMP1 Proteins Binding ICAM-1 and Is a Target of Cross-Reactive, Adhesion-Inhibitory Antibodies

    DEFF Research Database (Denmark)

    Bengtsson, Anja; Jørgensen, Louise; Rask, Thomas Salhøj;

    2013-01-01

    -exposed children. Our study challenges earlier conclusions that group A PfEMP1 proteins are not central to ICAM-1-specific IE adhesion and support the feasibility of developing a vaccine preventing cerebral malaria by inhibiting cerebral IE sequestration. The Journal of Immunology, 2013, 190: 240-249....

  12. 78 FR 10137 - Takes of Marine Mammals Incidental to Specified Activities; Marine Geophysical Survey on the Mid...

    Science.gov (United States)

    2013-02-13

    ... behavioral patterns, including, but not limited to, migration, breathing, nursing, breeding, feeding, or... Observatory would conduct all planned seismic activities with on-board assistance by the scientists who have... depths (approximately 1,600 m (5,249 ft)) in the Gulf of Mexico in 2007 and 2008. Results of the Gulf...

  13. 77 FR 19242 - Takes of Marine Mammals Incidental to Specified Activities; Low-Energy Marine Geophysical Survey...

    Science.gov (United States)

    2012-03-30

    ... causing disruption of behavioral patterns, including, but not limited to, migration, breathing, nursing... scientists who have proposed the study. The Principal Investigators for this survey are Drs. J. Lynch... depths (approximately 1,600 m (5,249 ft)) in the Gulf of Mexico. However, Tolstoy et al. (2004) did...

  14. 76 FR 57959 - Takes of Marine Mammals Incidental to Specified Activities; Marine Geophysical Survey in the...

    Science.gov (United States)

    2011-09-19

    ... of behavioral patterns, including, but not limited to, migration, breathing, nursing, breeding... instruments on the seafloor. These instruments will remain on the seafloor for 12 months and the scientists... (164 ft)) and deep-water depths (approximately 1,600 m (5,249 ft)) in the Gulf of Mexico in 2007...

  15. AcEST: DK945439 [AcEST

    Lifescience Database Archive (English)

    Full Text Available whole genome... 137 3e-31 tr|Q6ZZK5|Q6ZZK5_ACTTI Short chain dehydrogenase OS=Actinoplanes... 134 3e-30 tr|A...ASVVGFLASDGGEWVNGQVVRVNGGY 249 >tr|Q6ZZK5|Q6ZZK5_ACTTI Short chain dehydrogenase OS=Actinoplanes teichomycet

  16. The Needs Assessment of Implementing NTIS into the VTAE System. Final Report.

    Science.gov (United States)

    Rust, Leland

    A study investigated the competencies required to use the National Technical Information Service (NTIS) and the perceived need for its use for curriculum and instructional improvement in the Wisconsin Vocational, Technical, and Adult Education (VTAE) system. A representative sample (N=249) of VTAE instructors and staff was selected for the survey…

  17. Applications of holography. Citations from the NTIS data base

    Science.gov (United States)

    Carrigan, B.

    1980-05-01

    The bibliography covers studies on the applications of holography in such areas as photograping high-speed particles, nondestructive testing of material defects, strain analysis, microscopy, interferometry, vibration measurement, and medical diagnosis. This updated bibliography contains 249 abstracts, none of which are new entries to the previous edition.

  18. Hot wire anemometry. Citations from the NTIS data base

    Science.gov (United States)

    Habercom, G. E., Jr.

    1980-08-01

    Citations include principles; calibrating; circuit diagrams; flow measurement; hypersonic, supersonic, transonic, and subsonic characteristics; boundary layer studies; turbulence; jet, pipe, and tunnel flow; mathematical models; wind tunnel model tests, airport structure simulation; mass transfer and flow stability; probe modifications; flow about geometric forms; flow patterns; and related topics. This updated bibliography contains 249 citations, 28 of which are new entries to the previous edition.

  19. Production and investigation of thin films of metal actinides (Pu, Am, Cm, Bk, Cf)

    Science.gov (United States)

    Radchenko, V. M.; Ryabinin, M. A.; Stupin, V. A.

    2010-03-01

    Under limited availability of transplutonium metals some special techniques and methods of their production have been developed that combine the process of metal reduction from a chemical compound and preparation of a sample for examination. In this situation the evaporation and condensation of metal onto a substrate becomes the only possible technology. Thin film samples of metallic 244Cm, 248Cm and 249Bk were produced by thermal reduction of oxides with thorium followed by deposition of the metals in the form of thin layers on tantalum substrates. For the production of 249Cf metal in the form of a thin layer the method of thermal reduction of oxide with lanthanum was used. 238Pu and 239Pu samples in the form of films were prepared by direct high temperature evaporation and condensation of the metal onto a substrate. For the production of 241Am films a gram sample of plutonium-241 metal was used containing about 18 % of americium at the time of production. Thermal decomposition of Pt5Am intermetallics in vacuum was used to produce americium metal with about 80% yield. Resistivity of the metallic 249Cf film samples was found to decrease exponentially with increasing temperature. The 249Cf metal demonstrated a tendency to form preferably a DHCP structure with the sample mass increasing. An effect of high specific activity on the crystal structure of 238Pu nuclide thin layers was studied either.

  20. Production and investigation of thin films of metal actinides (Pu, Am, Cm, Bk, Cf)

    International Nuclear Information System (INIS)

    Under limited availability of transplutonium metals some special techniques and methods of their production have been developed that combine the process of metal reduction from a chemical compound and preparation of a sample for examination. In this situation the evaporation and condensation of metal onto a substrate becomes the only possible technology. Thin film samples of metallic 244Cm, 248Cm and 249Bk were produced by thermal reduction of oxides with thorium followed by deposition of the metals in the form of thin layers on tantalum substrates. For the production of 249Cf metal in the form of a thin layer the method of thermal reduction of oxide with lanthanum was used. 238Pu and 239Pu samples in the form of films were prepared by direct high temperature evaporation and condensation of the metal onto a substrate. For the production of 241Am films a gram sample of plutonium-241 metal was used containing about 18 % of americium at the time of production. Thermal decomposition of Pt5Am intermetallics in vacuum was used to produce americium metal with about 80% yield. Resistivity of the metallic 249Cf film samples was found to decrease exponentially with increasing temperature. The 249Cf metal demonstrated a tendency to form preferably a DHCP structure with the sample mass increasing. An effect of high specific activity on the crystal structure of 238Pu nuclide thin layers was studied either.

  1. Is Motor Performance in 5.5-Year-Old Children Associated with the Presence of Generalized Joint Hypermobility?

    NARCIS (Netherlands)

    Boer, R.M. de; Vlimmeren, L.A. van; Scheper, M.C.; Sanden, M.W. van der; Engelbert, R.H.

    2015-01-01

    OBJECTIVE: To determine the prevalence of generalized joint hypermobility (GJH) in Dutch children aged 5.5 years, and to examine the association between GJH and motor performance and development over time. STUDY DESIGN: A prospective cohort of 249 children was recruited. GJH was assessed with the Be

  2. Self-Efficacy, Gender and Trait Anxiety as Moderators of Test Anxiety

    Science.gov (United States)

    Onyeizugbo, Euckay U.

    2010-01-01

    Introduction: Test anxiety inhibits students from performing according to their full potential in academic setting. Objectives: This study investigated self-efficacy, gender and trait anxiety as moderators of test anxiety. Method: Two hundred and forty nine (249) psychology majors drawn from a university in Eastern Nigeria participated in the…

  3. ABA and Diverse Cultural and Linguistic Environments: A Welsh Perspective

    Science.gov (United States)

    Jones, E. W.; Hoerger, M.; Hughes, J. C.; Williams, B. M.; Jones, B.; Moseley, Y.; Hughes, D. R.; Prys, D.

    2011-01-01

    Gwynedd Local Education Authority (LEA) in North West Wales, UK, is funding a small-scale autism-specific specialist education service using ABA methodology. The program is available through the medium of Welsh, English or bilingually, depending on the individual needs of the child (Jones and Hoerger in Eur J Behav Anal 10:249-253, "2009").…

  4. Final Report of the Evaluation of the 1969-1970 Benjamin Franklin Cluster Program: Programs and Patterns for Disadvantaged High School Students. ESEA Title I.

    Science.gov (United States)

    Hoffman, Louis J.

    The Cluster Program at Benjamin Franklin High School, funded under Title I of the 1965 Elementary Secondary Education Act, is designed to be a school within a school in which 249 ninth grade students attend classes in two separate clusters. Each cluster is formulated such that all students receive instruction from five teachers in classes whose…

  5. Data of evolutionary structure change: 1ALCA-1VEDA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1ALCA-1VEDA 1ALC 1VED A A KQFTKCELSQNL--YDIDGYGRIALPELICTMFHTSGYD...CA 233 THR CA 295 GLU CA 388 TYR CA 428 1VED... A 1VEDA ASP CA 290 1VED A 1VED... CA 249 GLU CA 193 GLN CA 219 TRP CA 312 1VED

  6. 76 FR 63573 - Roundtable on Issues Relating to Conflict Minerals

    Science.gov (United States)

    2011-10-13

    ... COMMISSION 17 CFR Parts 229 and 249 Roundtable on Issues Relating to Conflict Minerals AGENCY: Securities and... conflict minerals originating in the Democratic Republic of the Congo and adjoining countries. Roundtable... reporting regulations regarding the use of conflict minerals from the Democratic Republic of the Congo...

  7. 76 FR 6110 - Conflict Minerals

    Science.gov (United States)

    2011-02-03

    ... FR 80948 (December 23, 2010)]. The original comment period for Release No. 34-63547 is scheduled to... COMMISSION 17 CFR Parts 229 and 249 RIN 3235-AK84 Conflict Minerals AGENCY: Securities and Exchange... 1934 (the ``Exchange Act'') and would require any such issuer for which conflict minerals are...

  8. Book Review

    Directory of Open Access Journals (Sweden)

    Dedy Darnaedi

    2012-12-01

    Full Text Available B.S. Parris, R. Kiew, R.C.K. Chung, L.G. Saw  & E. Soepadmo (eds. 2010. Flora of Peninsular Malaysia, Series I. Ferns and Lycophytes. Vol  1.  Malayan Forest Records No. 48. Forest Research Institute Malaysia, Ministry of Natural Resources and Environment, Malaysia, 249 pp. Price: RM80/USD60. 

  9. Gas scrubbers used in pollution control. 1976-February, 1980 (citations from the American Petroleum Institute). Report for 1976-February 1980

    Energy Technology Data Exchange (ETDEWEB)

    Cavagnaro, D.M.

    1980-05-01

    The citations from a worldwide literature survey relate to particle and gas scrubbers. The reports discuss design, performance, gas flow characteristics, and chemistry of the pollutants. Pollution control of SO/sub 2/, NOx, CO, Co/sub 2/, hydrocarbons, and particles is considered. (This updated bibliography contains 249 abstracts, 47 of which are new entries to the previous edition.)

  10. Using Fun in the Statistics Classroom: An Exploratory Study of College Instructors' Hesitations and Motivations

    Science.gov (United States)

    Lesser, Lawrence M.; Wall, Amitra A.; Carver, Robert H.; Pearl, Dennis K.; Martin, Nadia; Kuiper, Shonda; Posner, Michael A.; Erickson, Patricia; Liao, Shu-Min; Albert, Jim; Weber, John J., III

    2013-01-01

    This study examines statistics instructors' use of fun as well as their motivations, hesitations, and awareness of resources. In 2011, a survey was administered to attendees at a national statistics education conference, and follow-up qualitative interviews were conducted with 16 of those ("N" = 249) surveyed to provide further…

  11. 77 FR 50114 - Food and Drug Administration Modernization Act of 1997: Modifications to the List of Recognized...

    Science.gov (United States)

    2012-08-20

    .... Radiology 12-102 ANSI/IESNA RP-27.2-00 CFR citation and product Recommended Practice for codes, devices.... Radiology 12-249 Photobiological safety of IEC 62471 First lamps and lamp systems. edition 2006-07. I... the Federal Register of February 25, 1998 (63 FR 9561), FDA announced the availability of a...

  12. 12 CFR 335.311 - Forms for annual, quarterly, current, and other reports of issuers.

    Science.gov (United States)

    2010-01-01

    ... Results of Operations can be found at 17 CFR 229.300. Industry Guide 3, Statistical Disclosure by Bank..., and other reports are codified in subpart D of 17 CFR part 249. All forms shall be filed with the FDIC... for Financial Statements can generally be found in Regulation S-X (17 CFR part 210). Banks may...

  13. AcEST: BP914857 [AcEST

    Lifescience Database Archive (English)

    Full Text Available UMAN Helicase SRCAP OS=Homo sapiens GN=SRCAP PE... 48 2e-05 sp|Q9NDJ2|DOM_DROME Helicase domino OS=Drosophil...MLAE 199 + +K Q LE +KKALD HLDF+VGQTE+YS +L++ Sbjct: 213 VQFKQQSRLEEKRKKALDLHLDFIVGQTEKYSDLLSQ 249 >sp|Q9NDJ2|DOM_DROME Helicase domin

  14. AcEST: BP919933 [AcEST

    Lifescience Database Archive (English)

    Full Text Available case SRCAP OS=Homo sapiens GN=SRCAP PE... 66 1e-10 sp|Q9NDJ2|DOM_DROME Helicase domino OS=Drosophila melanog...QFWSNVEKVVQFKQQSRLEEKRKKALDLHLDFIVGQTEKYSDLLSQ 249 >sp|Q9NDJ2|DOM_DROME Helicase domino OS=Drosophila melano

  15. AcEST: BP920718 [AcEST

    Lifescience Database Archive (English)

    Full Text Available RS2|SRCAP_HUMAN Helicase SRCAP OS=Homo sapiens GN=SRCAP PE... 76 8e-14 sp|Q9NDJ2|DOM_DROME Helicase domino O... HLDF+VGQTE+YS +L++ Sbjct: 191 LRRIASTMAKDVRQFWSNVEKVVQFKQQSRLEEKRKKALDLHLDFIVGQTEKYSDLLSQ 249 >sp|Q9NDJ2|DOM_DROME Helicase domino

  16. AcEST: BP912286 [AcEST

    Lifescience Database Archive (English)

    Full Text Available OS=Homo sapiens GN=SRCAP PE... 72 3e-12 sp|Q9NDJ2|DOM_DROME Helicase domino OS=Drosophila melanogaster G... ...VGQTE+YS +L++ Sbjct: 194 IASTMAKDVRQFWSNVEKVVQFKQQSRLEEKRKKALDLHLDFIVGQTEKYSDLLSQ 249 >sp|Q9NDJ2|DOM_DROME Helicase domino

  17. AcEST: BP920558 [AcEST

    Lifescience Database Archive (English)

    Full Text Available ue sp|Q6ZRS2|SRCAP_HUMAN Helicase SRCAP OS=Homo sapiens GN=SRCAP PE... 81 3e-15 sp|Q9NDJ2|DOM_DROME Helicase domino...FKQQSRLEEKRKKALDLHLDFIVGQTEKYSD 245 Query: 347 MLAE 336 +L++ Sbjct: 246 LLSQ 249 >sp|Q9NDJ2|DOM_DROME Helicase domino

  18. AcEST: BP915811 [AcEST

    Lifescience Database Archive (English)

    Full Text Available N=SRCAP PE... 48 3e-05 sp|Q9NDJ2|DOM_DROME Helicase domino OS=Drosophila melanogaster G... 44 3e-04 sp|P4996... 213 VQFKQQSRLEEKRKKALDLHLDFIVGQTEKYSDLLSQ 249 >sp|Q9NDJ2|DOM_DROME Helicase domino OS=Drosophila melanogast

  19. AcEST: BP920230 [AcEST

    Lifescience Database Archive (English)

    Full Text Available .. 76 5e-14 sp|Q9NDJ2|DOM_DROME Helicase domino OS=Drosophila melanogaster G... 70 3e-12 sp|Q9NEL2|SSL1_CAEE...IVGQTEKYSDLLSQ 249 >sp|Q9NDJ2|DOM_DROME Helicase domino OS=Drosophila melanogaster GN=dom PE=1 SV=2 Length =

  20. Cyberbullying Behaviors among Female College Students: Witnessing, Perpetration, and Victimization

    Science.gov (United States)

    Selkie, Ellen M.; Kota, Rajitha; Moreno, Megan

    2016-01-01

    Problem: Cyberbullying is common among adolescents, and emerging studies also describe this phenomenon in college students. Less is known about specific cyberbullying behaviors and roles in cyberbullying incidents experienced by college females. Methods: 249 female students from 4 colleges completed online surveys assessing involvement in 11…

  1. Use of asthma medication during pregnancy and risk of specific congenital anomalies

    DEFF Research Database (Denmark)

    Garne, Ester; Hansen, Anne Vinkel; Morris, Joan;

    2015-01-01

    . In addition, exploratory analyses were done for each nonsignal anomaly. The data set included 76,249 registrations of congenital anomalies from 13 EUROmediCAT registries. RESULTS: Cleft palate (OR, 1.63; 95% CI, 1.05-2.52) and gastroschisis (OR, 1.89; 95% CI, 1.12-3.20) had significantly increased odds...

  2. HEMATOPOIETIC SYSTEM

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    12.1 Leukocyte and leukocyte function2003360 Expression of vascular endothelial growth factor and its receptors KDR and Fltl in acute myeloid leukemia. WANG Yi(王一), et al. Instit Hematol, CAMS & PUMC, Tianjin 300020. Chin J Hematol 2003;24(5):249-252Objective: To evaluate the expression of vascular endothelial growth factor (VEGF) and its receptors KDR

  3. Music during Lectures: Will Students Learn Better?

    Science.gov (United States)

    Dosseville, Fabrice; Laborde, Sylvain; Scelles, Nicolas

    2012-01-01

    We investigated the influence of music during learning on the academic performance of undergraduate students, and more particularly the influence of affects induced by music. Altogether 249 students were involved in the study, divided into a control group and an experimental group. Both groups attended the same videotaped lecture, with the…

  4. Bk and Cf chromatographic separation and ²⁴⁹Bk/²⁴⁸Cm and ²⁴⁹Cf/²⁴⁸Cm elemental ratios determination by inductively coupled plasma quadrupole mass spectrometry.

    Science.gov (United States)

    Gourgiotis, A; Isnard, H; Nonell, A; Aubert, M; Stadelmann, G; Dupont, E; AlMahamid, I; Tiang, G; Rao, L; Lukens, W; Cassette, P; Panebianco, S; Letourneau, A; Chartier, F

    2013-03-15

    The French Atomic Energy Commission has carried out several experiments for the study of minor-actinide transmutation processes in high intensity thermal neutron flux. In this context a Cm sample enriched in (248)Cm (∼97%) was irradiated in a thermal neutron flux at the High Flux Reactor (HFR) of the Laue-Langevin Institute (ILL). The precise and accurate determination of Cf isotope ratios and of (249)Bk/(248)Cm and (249)Cf/(248)Cm elemental ratios in the (248)Cm irradiated sample is crucial for the calculation of actinide neutron capture cross-sections. This work describes an analytical procedure for the separation and the isotope ratio measurement of Bk and Cf in the irradiated sample. The Bk and Cf separation is based on a lanthanides separation protocol previously developed by the laboratory. Well-defined retention times for Bk and Cf were obtained by coupling the Ionic Chromatography (IC) with an ICP-QMS. All conditions of element separation by IC and the different steps of the analytical protocol in order to obtain the isotopic and elemental ratios are presented. Relative uncertainties of Cf isotopic ratios range from 0.3% to 0.5% and the uncertainty of the (249)Bk/(248)Cm and (249)Cf/(248)Cm elemental ratios are respectively 6.1% and 3.2%. This level of uncertainty for both isotopic and elemental ratios is in perfect agreement with the requirement for transmutation studies. PMID:23598093

  5. Dicty_cDB: Contig-U04058-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 09 |pid:none) Gossypium thurberi ubiquitin-conju... 130 2e-29 CP000585_249( CP000585 |pid:none) Ostreococcus...83533.... 130 2e-29 (Q9SLE4) RecName: Full=Ubiquitin carrier protein E2 29; ... 130 2e-29 AY082009_1( AY0820

  6. Characterisation of antioxidant and antiproliferative acidic polysaccharides from Chinese wolfberry fruits

    NARCIS (Netherlands)

    He, N.W.; Yang, X.B.; Jiao, Y.D.; Tian, L.; Zhao, Y.

    2012-01-01

    Wolfberry fruit polysaccharides (WFPs) were isolated by hot-water extraction and ethanol precipitation. With HPLC analysis, WFPs were for the first time identified as acidic polysaccharides with galacturonic acid being the main component monosaccharide (24.9%), followed by galactose (21.3%), arabino

  7. 78 FR 28636 - Notice of Determinations Regarding Eligibility To Apply for Worker Adjustment Assistance

    Science.gov (United States)

    2013-05-15

    ... UnitedHealth Group, Optum, Inc., Bloomington, MN. Optum Shared Services, Business Operations, Genesis 10. 82,249S UnitedHealth Group, Optum, Inc., Golden Valley, MN. Optum Shared Services, Business... following must be satisfied: (A) Imports of articles or services like or directly competitive with...

  8. The Developmental Trajectories of Executive Function of Children and Adolescents with Attention Deficit Hyperactivity Disorder

    Science.gov (United States)

    Qian, Ying; Shuai, Lan; Chan, Raymond C. K.; Qian, Qiu-Jin; Wang, Yufeng

    2013-01-01

    This study examined the developmental trajectories of executive function (EF) of children and adolescents with Attention Deficit Hyperactivity Disorder (ADHD) in Han Chinese. Five hundred and fifteen children and adolescents with ADHD and 249 healthy controls took part in this study. All of them were administered four EF tests capturing…

  9. The work of Powers and Brownyard revisited: Part 2

    NARCIS (Netherlands)

    Brouwers, H.J.H.

    2005-01-01

    Powers and Brownyard [T.C. Powers, T.L. Brownyard, Studies of the physical properties of hardened Portland cement paste, Bull. 22, Res. Lab. of Portland Cement Association, Skokie, IL, U.S., 1948 reprinted from J. Am. Concr. Inst. (Proc.), 43, 1947, pp. 101–132, pp. 249–336, pp. 469–505, pp. 549–602

  10. The work of Powers and Brownyard revisited: Part 1

    NARCIS (Netherlands)

    Brouwers, H.J.H.

    2004-01-01

    Powers and Brownyard [Studies of the physical properties of hardened Portland cement paste. Bull. 22, Res. Lab. of Portland Cement Association, Skokie, IL, U.S. J. Am. Concr. Inst. (Proc.), 43 (1947) 101–132, 249–336, 469–505, 549–602, 669–712, 845–880, 933–992 (reprint)] were the first to systemati

  11. Results of a Multisite Survey of U.S. Psychiatry Residents on Education in Professionalism and Ethics

    Science.gov (United States)

    Jain, Shaili; Dunn, Laura B.; Warner, Christopher H.; Roberts, Laura Weiss

    2011-01-01

    Objective: The authors assess the perspectives of psychiatry residents about the goals of receiving education in professionalism and ethics, how topics should be taught, and on what ethical principles the curriculum should be based. Method: A written survey was sent to psychiatry residents (N = 249) at seven U.S. residency programs in Spring 2005.…

  12. 78 FR 70544 - Notice of Public Hearing and Business Meeting

    Science.gov (United States)

    2013-11-26

    .... Schmitt at 609-883- 9500 ext. 224. Addresses for Written Comment. Written comment on items scheduled for... Commission Secretary directly at 609-883- 9500 ext. 203 or through the Telecommunications Relay Services (TRS... Commission's offices by appointment by contacting Carol Adamovic, 609-883-9500, ext. 249. For other...

  13. 78 FR 54244 - Notice of Public Hearing and Business Meeting

    Science.gov (United States)

    2013-09-03

    ... phoning Ms. Schmitt at 609-883- 9500 ext. 224. Addresses for Written Comment. Written comment on items..., conference session or hearings should contact the Commission Secretary directly at 609-883- 9500 ext. 203 or... Adamovic, 609-883-9500, ext. 249. For other questions concerning hearing items, please contact...

  14. Osteoporosis or Low Bone Mass at the Femur Neck or Lumbar Spine in Older Adults: United States, 2005-2008

    Science.gov (United States)

    ... HW, Dunn WL, Calvo MS, et al. Updated data on proximal femur bone mineral levels of U.S. adults. Osteoporos Int 8:468–89. 1998. Kelly TJ. Bone mineral density reference databases for American men and women. J Bone Miner Res 5 (Suppl1):S249. 1990. Centers for Disease ...

  15. The Family Backpack Project: Responding to Dual-Language Texts through Family Journals

    Science.gov (United States)

    Rowe, Deborah; Fain, Jeanne Gilliam

    2013-01-01

    The Family Backpack Project provided 249 low-income, prekindergarten children and their families with opportunities to read and listen to audio recordings of 3 sets of books in their homes. Families received English or dual-language texts (English plus Spanish, Arabic, Kurdish, or Somali) matched to their home languages. Children and their…

  16. El modelo de la diversidad. La Bioética y los Derechos Humanos como herramientas para alcanzar la plena dignidad en la diversidad funcional [book review

    OpenAIRE

    Morente Parra, Vanesa

    2007-01-01

    Este artículo reseña: Palacios, Agustina; Romañach, Javier. El modelo de la diversidad. La Bioética y los Derechos Humanos como herramientas para alcanzar la plena dignidad en la diversidad funcional. Madrid: Diversitás Ediciones, 2006. 249 p.

  17. Magnetic measurements of the transuranium elements. Progress report, January 1, 1984-December 31, 1984

    International Nuclear Information System (INIS)

    Measurements of the magnetic properties of dhcp californium-249 metal indicated the presence of three regions of differing magnetic character. Additional measurements are also reported. Magnetic moments and valence states of terbium in TbF3, BaTbO3, and TbO18 are discussed. Progress on high-field operation of the micro-magnetic susceptometer is reported

  18. Gclust Server: 62015 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 62015 DPTM_GSPATP00018828001 Cluster Sequences Related Sequences(1) 249 no annotati...on 2 1.00e-45 0.0 11.11 0.0 0.0 0.0 0.0 Show 62015 Cluster ID 62015 Sequence ID DPTM_GSPATP00018828001 Link

  19. SAE Scope and Student Achievement in Agribusiness and Natural Resources Education.

    Science.gov (United States)

    Arrington, Larry R.; Cheek, Jimmy G.

    1990-01-01

    Study determined relationship between scope of supervised agricultural experience (SAE) as measured by total income and Productive Man Work Units (PMWU) and level of achievement of students enrolled in vocational agriculture classes in Florida. Responses from 98 Applied Principles and 249 Fundamentals students found low SAE participation and…

  20. 77 FR 73589 - Positive Train Control Systems (RRR)

    Science.gov (United States)

    2012-12-11

    ... of processor-based train control systems. See 70 FR 11,052 (Mar. 7, 2005) (codified at 49 CFR part... passenger trains operating at greater than 59 miles per hour under Sec. 236.0(c)(2). See 75 FR 2598 at 2607...); Louisville Jeffersonville Bridge Co. v. United States, 249 U.S. 543 (1919); see also 66 FR 4104, 4148 (Jan...

  1. Determinants of Linear Judgment: A Meta-Analysis of Lens Model Studies

    Science.gov (United States)

    Karelaia, Natalia; Hogarth, Robin M.

    2008-01-01

    The mathematical representation of E. Brunswik's (1952) lens model has been used extensively to study human judgment and provides a unique opportunity to conduct a meta-analysis of studies that covers roughly 5 decades. Specifically, the authors analyzed statistics of the "lens model equation" (L. R. Tucker, 1964) associated with 249 different…

  2. Sociolinguistic Variation and Change in British Sign Language Number Signs: Evidence of Leveling?

    Science.gov (United States)

    Stamp, Rose; Schembri, Adam; Fenlon, Jordan; Rentelis, Ramas

    2015-01-01

    This article presents findings from the first major study to investigate lexical variation and change in British Sign Language (BSL) number signs. As part of the BSL Corpus Project, number sign variants were elicited from 249 deaf signers from eight sites throughout the UK. Age, school location, and language background were found to be significant…

  3. Hepatocellular carcinoma and liver cirrhosis TP53 mutation analysis reflects a moderate dietary exposure to aflatoxins in Espírito Santo State, Brazil.

    Science.gov (United States)

    de Carvalho, Fernanda Magri; de Almeida Pereira, Thiago; Gonçalves, Patrícia Lofego; Jarske, Robson Dettmann; Pereira, Fausto Edmundo Lima; Louro, Iuri Drumond

    2013-08-01

    The close relationship between aflatoxins and 249ser TP53 gene mutation (AGG to AGT, Arg to Ser) in hepatocellular carcinoma (HCC) makes this mutation an indirect indicator of dietary contamination with this toxin. We have examined the prevalence of codon 249 TP53 mutation in 41 HCC and 74 liver cirrhosis (without HCC) cases diagnosed at the HUCAM University Hospital in Vitoria, Espírito Santo State, Brazil. DNA was extracted from paraffin sections and from plasma. The mutation was detected by DNA amplification, followed by restriction endonuclease digestion and confirmed by direct sequencing. DNA restriction showed 249ser mutation in 16 HCC and 13 liver cirrhosis, but sequencing confirmed mutations in only 6 HCC and 1 liver cirrhosis. In addition, sequencing revealed 4 patients with mutations at codon 250 (250ser and 250leu) in HCC cases. The prevalence of TP53 mutation was 10/41 (24.3%) in HCC and 1/74 (1.4%) in liver cirrhosis. No relationship between the presence of mutations and the etiology of HCC was observed. TP53 exon 7 mutations, which are related to aflatoxins exposure, were found at 14.6% (249ser), 7.3% (250leu) and 2.4% (250ser) in 41 cases of HCC and 1.4% in 74 liver cirrhosis (without HCC) cases, suggesting a moderate dietary exposure to aflatoxins in the Espírito Santo State, Brazil.

  4. Comparative evaluation of efficacy and safety of carboxymethylcellulose either alone or in combination with non-steroidal anti-inflammatory drug in the treatment of dry eye in a tertiary care teaching hospital

    Directory of Open Access Journals (Sweden)

    Saubhagya Sindhu

    2015-04-01

    Conclusion: Both groups showed significant improvement in Schirmer's test and TBUT test value and OSDI score at the end of the study. Intergroup comparison showed a significant difference with reference to OSDI score. Patients receiving NSAID reported more adverse effects. [Int J Basic Clin Pharmacol 2015; 4(2.000: 245-249

  5. Hemoglobin, Growth, and Attention of Infants in Southern Ethiopia

    Science.gov (United States)

    Aubuchon-Endsley, Nicki L.; Grant, Stephanie L.; Berhanu, Getenesh; Thomas, David G.; Schrader, Sarah E.; Eldridge, Devon; Kennedy, Tay; Hambidge, Michael

    2011-01-01

    Male and female infants from rural Ethiopia were tested to investigate relations among hemoglobin (Hb), anthropometry, and attention. A longitudinal design was used to examine differences in attention performance from 6 (M = 24.9 weeks, n = 89) to 9 months of age (M = 40.6 weeks, n = 85), differences hypothesized to be related to changes in iron…

  6. 78 FR 6132 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; Petition...

    Science.gov (United States)

    2013-01-29

    ...: Section 221 (a) of Title II, Chapter 2 of the Trade Act of 1974, as amended by the Trade and Globalization... each State to accept petitions for certification of eligibility to apply for adjustment assistance..., and 249 of the Trade Act of 1974, as amended by the Trade and Globalization Adjustment Assistance...

  7. Effects of attractiveness and status in dating desire in homosexual and heterosexual men and women

    NARCIS (Netherlands)

    Ha, P.T.; Berg, J.E.M. van den; Engels, R.C.M.E.; Lichtwarck-Aschoff, A.

    2012-01-01

    The present study examined partner preferences of homosexual and heterosexual men and woman, focusing on attractiveness and status. Homosexual (N = 591 men; M age = 28.87 years, SD = 10.21; N = 249 women; M age = 33.36 years, SD = 13.12) and heterosexual participants (N = 346 men; M age = 39.74 year

  8. Occupational Employment in Nuclear-Related Activities, 1981.

    Science.gov (United States)

    Baker, Joe G.; Olsen, Kathryn

    Employment in nuclear- and nuclear energy-related activities in 1981 was examined and compared to that in previous years. Survey instruments were returned by 784 establishments. Total 1981 nuclear-related employment was estimated to be 249,500--a growth of 22,600 (10%) workers over the 1977 total. Government-owned, contractor-operated (GOCO)…

  9. Myths and Misconceptions in Popular Psychology: Comparing Psychology Students and the General Public

    Science.gov (United States)

    Furnham, Adrian; Hughes, David J.

    2014-01-01

    This study examined the prevalence of psychological myths and misconceptions among psychology students and within the general population. In total, 829 participants completed a 249-item questionnaire designed to measure a broad range of psychological myths. Results revealed that psychological myths and misconceptions are numerous and widely held.…

  10. Investigation of Problem Solving Ability of Students in School of Physical Education and Sports (Kafkas University Sample)

    Science.gov (United States)

    Ozmutlu, Ilker

    2014-01-01

    The aim of this research is to examine the problem solving abilities of School of Physical Education and Sports students. To achieve this aim, in the academic year 2013-2014, a research group did a study of 433 students of the School of Physical Education and Sports, Kafkas University. This sample consisted of 184 female and 249 male students.…

  11. West Nile Virus Temperature Sensitivity and Avian Virulence Are Modulated by NS1-2B Polymorphisms.

    Science.gov (United States)

    Dietrich, Elizabeth A; Langevin, Stanley A; Huang, Claire Y-H; Maharaj, Payal D; Delorey, Mark J; Bowen, Richard A; Kinney, Richard M; Brault, Aaron C

    2016-08-01

    West Nile virus (WNV) replicates in a wide variety of avian species, which serve as reservoir and amplification hosts. WNV strains isolated in North America, such as the prototype strain NY99, elicit a highly pathogenic response in certain avian species, notably American crows (AMCRs; Corvus brachyrhynchos). In contrast, a closely related strain, KN3829, isolated in Kenya, exhibits a low viremic response with limited mortality in AMCRs. Previous work has associated the difference in pathogenicity primarily with a single amino acid mutation at position 249 in the helicase domain of the NS3 protein. The NY99 strain encodes a proline residue at this position, while KN3829 encodes a threonine. Introduction of an NS3-T249P mutation in the KN3829 genetic background significantly increased virulence and mortality; however, peak viremia and mortality were lower than those of NY99. In order to elucidate the viral genetic basis for phenotype variations exclusive of the NS3-249 polymorphism, chimeric NY99/KN3829 viruses were created. We show herein that differences in the NS1-2B region contribute to avian pathogenicity in a manner that is independent of and additive with the NS3-249 mutation. Additionally, NS1-2B residues were found to alter temperature sensitivity when grown in avian cells. PMID:27548738

  12. "I Like to Plan Events": A Document Analysis of Essays Written by Applicants to a Public Relations Program

    Science.gov (United States)

    Taylor, Ronald E.

    2016-01-01

    A document analysis of 249 essays written during a 5-year period by applicants to a public relations program at a major state university in the southeast suggests that there are enduring reasons why students choose to major in public relations. Public relations is described as a major that allows for and encourages creative expression and that…

  13. Attention-Deficit, Fear and Aggression in Iranian Preschool Students with Regard to Gender Differences

    Science.gov (United States)

    Sheikhzade, Mostafa; Assemi, Arezoo

    2013-01-01

    The cause of most adult psychopathologies or behavioural disorders can be traced back to childhood. In this study, we examine the attention-deficit, fear and aggression in Iran's preschool students in Oshnaviye city. In this analytical-descriptive study, 50 students were selected through stratified sampling method from 249 students. Data were…

  14. 50 CFR 660.50 - Pacific Coast treaty Indian fisheries.

    Science.gov (United States)

    2010-10-01

    ... issued pursuant to 25 CFR part 249, subpart A, is prima facie evidence that the holder is a member of the... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Pacific Coast treaty Indian fisheries. 660.50 Section 660.50 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC...

  15. 50 CFR 300.95 - Treaty Indian fisheries.

    Science.gov (United States)

    2010-10-01

    ... or engaged in any activity related to fishing the treaty Indian identification required by 25 CFR 249... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Treaty Indian fisheries. 300.95 Section 300.95 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL...

  16. AcEST: DK951813 [AcEST

    Lifescience Database Archive (English)

    Full Text Available dase OS=Pinus pinaster GN... 332 7e-90 tr|B8XF08|B8XF08_ONCHC Ascorbate peroxidase OS=Oncidium Gower Ra... 3...CHC Ascorbate peroxidase OS=Oncidium Gower Ramsey PE=2 SV=1 Length = 249 Score = 332 bits (850), Expect = 1e

  17. VIMOS-VLT and Spitzer observations of a radio galaxy at z=2.5

    NARCIS (Netherlands)

    Villar-Martin, M; Sanchez, SF; De Breuck, C; Peletier, R; Vernet, J; Rettura, A; Seymour, N; Humphrey, A; Stern, D; Alighieri, SD; Fosbury, R

    2006-01-01

    We present: (i) a kinematic and morphological study of the giant Ly alpha nebula associated with the radio galaxy MRC 2104-242 (z = 2.49) based on integral field spectroscopic Visible Multiobject Spectrograph (VIMOS) data from the Very Large Telescope (VLT), and (ii) a photometric study of the host

  18. Ultraviolet photodissociation of the van der Waals dimer (CH3I)(2) revisited. II. Pathways giving rise to neutral molecular iodine

    NARCIS (Netherlands)

    Vidma, K.V.; Baklanov, A.V.; Zhang, Y.W.; Parker, D.H.

    2006-01-01

    The formation of neutral I-2 by the photodissociation of the methyl iodide dimer, (CH3I)(2), excited within the A band at 249.5 nm is evaluated using velocity map imaging. In previous work [J. Chem. Phys. 122, 204301 (2005)], we showed that the formation of I-2(+) from photodissociation of the methy

  19. Financial Information Source, Knowledge, and Practices of College Students from Diverse Backgrounds

    Science.gov (United States)

    Mimura, Yoko; Koonce, Joan; Plunkett, Scott W.; Pleskus, Lindsey

    2015-01-01

    Using cross-sectional data, we examined the financial information sources, financial knowledge, and financial practices of young adults, many of whom are first generation college students, ethnic minorities, and immigrants or children of immigrants. Participants (n = 1,249) were undergraduate students at a large regional comprehensive university.…

  20. ISOLATION OF TOXOPLASMA GONDII FROM ANIMALS IN DURANGO, MEXICO

    Science.gov (United States)

    Little is known concerning the epidemiology of Toxoplasma gondii infection in people and animals in rural Mexico. Serum samples and tissues from 150 dogs, 150 cats, 65 opossums (Didelphis virginianus), 249 rats (Rattus spp.), 127 mice (Mus musculus), and 69 squirrels (Spermophilus variegatus) from t...

  1. Practice (Rather than Graded) Quizzes, with Answers, May Increase Introductory Psychology Exam Performance

    Science.gov (United States)

    Wickline, Virginia B.; Spektor, Valeriya G.

    2011-01-01

    The authors investigated whether practice (or graded) quizzes, with or without provision of correct answers, would be more beneficial for introductory psychology exam performance. In six sections (N = 249) of an introductory psychology class, taught by the same professor, different approaches to quizzes were applied across sections to measure…

  2. 78 FR 4766 - Adoption of Updated EDGAR Filer Manual

    Science.gov (United States)

    2013-01-23

    ... COMMISSION 17 CFR Parts 232, 239, 249, 269, 274 Adoption of Updated EDGAR Filer Manual AGENCY: Securities and...) Filer Manual and related rules to reflect updates to the EDGAR system. The revisions are being made...: Effective Date: January 23, 2013. The incorporation by reference of the EDGAR Filer Manual is approved...

  3. Pesticide residues in fruit and vegetables from Africa - a Nordic Project

    DEFF Research Database (Denmark)

    Petersen, Annette

    . Most of the samples came from South Africa (249), followed by Egypt (129), Morocco (92) and Kenya (88). In total 45 different commodities were analyzed, oranges (162) being the largest group, followed by beans with pods (80) and table grapes (71). In the analytical scope 220 to 345 pesticides and...

  4. An integrated catalog of reference genes in the human gut microbiome

    NARCIS (Netherlands)

    Li, J.; Jia, H.; Cai, X.; Zhong, H.; Feng, Q.; Sunagawa, S.; Arumugam, M.; Kultima, J.R.; Prifti, E.; Nielsen, T.; Juncker, A.S.; Manichanh, C.; Chen, B.; Zhang, W.; Levenez, F.; Xu, X.; Xiao, L.; Liang, S.; Zhang, D.; Zhang, Z.; Chen, W.; Zhao, H.; Al-Aama, J.Y.; Edris, S.; Yang, H.; Hansen, H.; Nielsen, H.B.; Brunak, S.; Kristiansen, K.; Guarner, F.; Pedersen, O.; Doré, J.; Ehrlich, S.D.; Bork, P.; Wang, J.; Vos, de W.M.; Tims, S.; Zoetendal, E.G.; Kleerebezem, M.

    2014-01-01

    Many analyses of the human gut microbiome depend on a catalog of reference genes. Existing catalogs for the human gut microbiome are based on samples from single cohorts or on reference genomes or protein sequences, which limits coverage of global microbiome diversity. Here we combined 249 newly seq

  5. 48 CFR 2152.370 - Use of the matrix.

    Science.gov (United States)

    2010-10-01

    ... Subcontractor Sales to the Government M FAR 52.203-7 FAR 3.502-3 Anti-Kickback Procedures M FAR 52.203-12 FAR 3... 47.405 Preference for U.S.-Flag Air Carriers M FAR 52.249-2 FAR 49.502(b)(1)(i) Termination...

  6. 48 CFR 2152.070 - Applicable clauses.

    Science.gov (United States)

    2010-10-01

    ...-3Gratuities 52.203-5Covenant against Contingent Fees 52.203-6Restrictions on Subcontractor Sales to the...-63Preference for U.S.-Flag Air Carriers 52.249-2Termination for Convenience of the Government (Fixed Price)...

  7. Balti kirjakultuuri mitmekeelsest loomust / Liina Lukas

    Index Scriptorium Estoniae

    Lukas, Liina, 1970-

    2008-01-01

    Poleemika senise rahvuslik-keelelise lähenemisega eesti varasemale kirjandusloole. 17. saj. Eestimaal viljeldud uusladina luulest Euroopa kirjandusnähtuste taustal (ka Reiner Brockmanni eestikeelsest juhuluuleharrastusest) ning 19. saj. lõpuni püsinud mitmekeelsusest siinses kultuuris. Ka ettepanek kasutada seoses Eestimaa mitmekeelse kultuuriga "balti kirjakultuuri" mõistet. Sisaldab bibliograafiat. Autorist lk. 249

  8. Dicty_cDB: Contig-U14695-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available om... 44 4.8 1 ( DL005648 ) NUCLEIC ACID PROBES AND NUCLEIC ACID ANALOG PROBES. 4...180 ) Rattus norvegicus clone CH230-249D12, WORKING DRA... 40 5.0 5 ( DL005646 ) NUCLEIC ACID PROBES AND NUCLEIC

  9. 75 FR 64641 - Facilitating Shareholder Director Nominations

    Science.gov (United States)

    2010-10-20

    ... COMMISSION 17 CFR Parts 200, 232, 240, and 249 RIN 3235-AK27 Facilitating Shareholder Director Nominations... rules that the Commission adopted to facilitate the effective exercise of shareholders' traditional state law rights to nominate and elect directors to company boards of directors. We are publishing...

  10. "Euroopa viimased metslased" : eestlased saksa koloniaaldiskursis 1770-1870 / Ulrike Plath

    Index Scriptorium Estoniae

    Plath, Ulrike

    2008-01-01

    Eesti ja läti pärisorjade võrdlemisest metslastega, eestlaste "eksoteerimisest", põhjuseks keelesugulus saamide ja samojeedidega. Pikemalt Johann Georg Kohli teosest "Die Völker Europas" (1868). Baltisaksa koloniaaldiskursi kujunemisest 19. sajandil. Sisaldab bibliograafiat. Autorist lk. 249

  11. Measuring Attitude Functions.

    Science.gov (United States)

    Anderson, Deborah S.; Kristiansen, Connie M.

    1990-01-01

    Discusses the Attitude Functions Inventory (AFI), which assesses the extent to which a person's attitude fulfills each of four psychological functions. Reports findings of a study, involving 249 undergraduates, that tested the construct validity of the AFI. Suggests that the AFI provides conceptually meaningful measures of the functions of…

  12. AcEST: BP919402 [AcEST

    Lifescience Database Archive (English)

    Full Text Available M930|MATK_PAUTO Maturase K OS=Paulownia tomentosa GN=matK P... 30 3.9 sp|Q6EIJ9|MATK_FRECA Maturase K OS=Fre... K PC Sbjct: 249 FYGKVERLVNVFGKVKDFQENLWLVKEPC 277 >sp|Q8M930|MATK_PAUTO Maturase K OS=Paulo

  13. AcEST: DK957828 [AcEST

    Lifescience Database Archive (English)

    Full Text Available Definition tr|B8XF08|B8XF08_ONCHC Ascorbate peroxidase OS=Oncidium Gower Ramsey Align length 169 Score (bit...oxidase OS=Oncidium Gower Ramsey PE=2 SV=1 Length = 249 Score = 300 bits (767), Expect = 3e-80 Identities =

  14. 8 CFR 1240.49 - Ancillary matters, applications.

    Science.gov (United States)

    2010-01-01

    ... 249 of the Act. The application shall be subject to the requirements of 8 CFR parts 1240, 1245, and... the Act shall be made to the director in accordance with 8 CFR part 1216. In conjunction with any..., in accordance with the provisions of section 213A of the Act and 8 CFR part 213a. In...

  15. 76 FR 6009 - Shareholder Approval of Executive Compensation and Golden Parachute Compensation

    Science.gov (United States)

    2011-02-02

    ... Item 20 of Schedule 14A; TARP Adopting Release, supra note 18, at 75 FR 2790. b. Comments on the... Executive Compensation and Golden Parachute Compensation; Final Rule #0;#0;Federal Register / Vol. 76, No... 17 CFR Parts 229, 240 and 249 RIN 3235-AK68 Shareholder Approval of Executive Compensation and...

  16. 75 FR 64752 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2010-10-20

    .... Extension: Form N-CSR, SEC File No. 270-512, OMB Control No. 3235-0570. Notice is hereby given that... extension of the previously approved collection of information discussed below. Form N-CSR (17 CFR 249.331... N-CSR is to be used for reports under Section 30(b)(2) of the Investment Company Act and Section...

  17. Domain Modeling: NP_001020371.3 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_001020371.3 chr16 Eukaryotic proteases d1bmla_ chr16/NP_001020371.3/NP_001020371.3..._apo_16-263.pdb d1buib_ chr16/NP_001020371.3/NP_001020371.3_holo_16-263.pdb blast 28L,29S,249V,250A 34I,35

  18. Complete Genome Sequence of Corynebacterium camporealensis DSM 44610, Isolated from the Milk of a Manchega Sheep with Subclinical Mastitis.

    Science.gov (United States)

    Rückert, Christian; Albersmeier, Andreas; Winkler, Anika; Tauch, Andreas

    2015-01-01

    Corynebacterium camporealensis has been isolated in pure culture from milk samples of dairy sheep affected by subclinical mastitis. The complete genome sequence of the type strain DSM 44610, recovered from milk of a Manchega sheep, comprises 2,451,810 bp with a mean G+C content of 59.41% and 2,249 protein-coding genes. PMID:26021938

  19. EST Table: FY020340 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available 7 11/11/04 79 %/249 aa gnl|Amel|GB19218-PA 11/11/04 75 %/246 aa gi|189241909|ref|XP_970822.2| PREDICTED: similar to Darkener of apricot CG33553-PG [Tribolium castaneum] FS779323 bmov ...

  20. Data of evolutionary structure change: 1OZHA-1UPCD [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1OZHA-1UPCD 1OZH 1UPC A D VRQWAHGADLVVSQLEAQGVRQVFGIPGAKIDKVFDSLL...>LYS CA 249 VAL CA 284 1UPC D... 1UPCD LLGSSEGIDTPNPP HHH ... ILE CA 324 ASP CA 254 1UPC D 1UPCD GVVADGWQKAAD

  1. 17 CFR 239.13 - Form S-3, for registration under the Securities Act of 1933 of securities of certain issuers...

    Science.gov (United States)

    2010-04-01

    ... stock, as of a date within 60 days prior to the date of filing. See the definition of affiliate in... are quoted on the automated quotation system of a national securities association. In addition, Form S... statements were included in the registrant's latest filing on Form 20-F (17 CFR 249.220f). In complying...

  2. 50 CFR 300.64 - Fishing by U.S. treaty Indian tribes.

    Science.gov (United States)

    2010-10-01

    ... pursuant to 25 CFR part 249, subpart A, and must comply with the treaty Indian vessel and gear... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Fishing by U.S. treaty Indian tribes. 300.64 Section 300.64 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES...

  3. Birth weight and systolic blood pressure in adolescence and adulthood

    DEFF Research Database (Denmark)

    Gamborg, Michael; Byberg, Liisa; Rasmussen, Finn;

    2007-01-01

    The authors investigated the shape, sex- and age-dependency, and possible confounding of the association between birth weight and systolic blood pressure (SBP) in 197,954 adults from 20 Nordic cohorts (birth years 1910-1987), one of which included 166,249 Swedish male conscripts. Random...

  4. Intuitive visualizations of pitch and loudness in speech

    NARCIS (Netherlands)

    Schaefer, R.S.; Beijer, L.J.; Seuskens, W.L.J.B.; Rietveld, A.C.M.; Sadakata, M.

    2016-01-01

    Visualizing acoustic features of speech has proven helpful in speech therapy; however, it is as yet unclear how to create intuitive and fitting visualizations. To better understand the mappings from speech sound aspects to visual space, a large web-based experiment (n = 249) was performed to evaluat

  5. Cellular telephone use and cancer risk

    DEFF Research Database (Denmark)

    2006-01-01

    expected in the Danish population. RESULTS: A total of 14,249 cancers were observed (SIR = 0.95; 95% confidence interval [CI] = 0.93 to 0.97) for men and women combined. Cellular telephone use was not associated with increased risk for brain tumors (SIR = 0.97), acoustic neuromas (SIR = 0.73), salivary...

  6. Beyond Program Objectives.

    Science.gov (United States)

    Baessler, Matthew; Best, William; Sexton, Martha

    2016-06-01

    Graduate students in eight diverse health care professional programs participated together in a pilot course entitled, "An Interprofessional Approach to Patient Care." Through postcourse discussions with the clinical nurse leader students, faculty discovered that beyond meeting program objectives, the nursing learners gained numerous unexpected insights about interprofessional collaborative practice. J Contin Educ Nurs. 2016;47(6):248-249. PMID:27232220

  7. Beiträge zur Kenntnis der Pupillacea VII. Über zwei Wenig Bekannte Valloniidae

    NARCIS (Netherlands)

    Gittenberger, E.

    1977-01-01

    Spermodea spermatia (Da Silva e Castro) (Fig. 2) Helix spermatia J. da Silva e Castro, 1887: 249 (Locus typicus: "au bois de Bussaco", Bugaco, 40°22'N 8°21'W, etwa 15 km nnö. von Coimbra, Beira Litoral, Portugal — ? Syntypus: MHNG-Bgt2)). — A. Locard, 1899: 61. Helix (Acanthinula) spermatia — C. A.

  8. Multiple product channels in the collision-free UV photodissociation of 2-nitropropane

    Science.gov (United States)

    Radhakrishnan, G.; Parr, T.; Wittig, C.

    1984-10-01

    The one-photon, collision-free, UV (222, 249, and 308 nm) photodissociation of 2-nitropropane leads to several chemically distinct sets of products. We report the detection of OH, HONO and NO 2 and discuss mechanisms as well as implications concerning condensed phase reactions.

  9. QTL Information Table: 502 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qSBR-3 Resistance or Tolerance Sheath blight resistance Sheath blight response RFLP C)Interval DHL ZYQ8 Ji...ngxi 17 G249 G164 pha Kunihiro, Y., Qian, Q., Sato, H., Teng, S., Zeng, D.L., Fujimot

  10. Complete Genome Sequence of Corynebacterium camporealensis DSM 44610, Isolated from the Milk of a Manchega Sheep with Subclinical Mastitis

    OpenAIRE

    Rückert, Christian; Albersmeier, Andreas; Winkler, Anika; Tauch, Andreas

    2015-01-01

    Corynebacterium camporealensis has been isolated in pure culture from milk samples of dairy sheep affected by subclinical mastitis. The complete genome sequence of the type strain DSM 44610, recovered from milk of a Manchega sheep, comprises 2,451,810 bp with a mean G+C content of 59.41% and 2,249 protein-coding genes.

  11. Movements and site fidelity of harbour seals (Phoca vitulina) in Kattegat, Denmark, with implications for the epidemiology of the phocine distemper virus

    DEFF Research Database (Denmark)

    Dietz, R.; Teilmann, J.; Andersen, S.M.;

    2013-01-01

    Kattegat with a maximum distance of 249 km from the tagging haul-out site. Overall, females travelled over a wider area compared with males [90% kernel home range (KHR) females, 5189 km2; males, 3293 km2). KHR calculated for yearlings (6414 km2) is larger than for subadults (2534 km2), which again...

  12. Intergenerational Relationships in Cross-Cultural Comparison: How Social Networks Frame Intergenerational Relations between Mothers and Grandmothers in Japan, Korea, China, Indonesia, Israel, Germany, and Turkey

    Science.gov (United States)

    Nauck, Bernhard; Suckow, Jana

    2006-01-01

    The article explores the relevance of intergenerational relationships within the overall network of young mothers and grandmothers in seven societies: Japan, Korea, China, Indonesia, Turkey, Israel, and Germany. The empirical base is 2,945 named network members in 249 pairs of interviews of grandmothers and their daughters from a cross-cultural…

  13. Significance of size in occurrence, distribution, morphological characteristics, abundance, and resource evaluation of polymetallic nodules

    Digital Repository Service at National Institute of Oceanography (India)

    Valsangkar, A.B.; Rebello, J.M.S.

    About 13,000 different sized nodules from 249 locations covering 75,000 km2 relinquished Pioneer area in the Central Indian Basin (CIB) have been studied by assorting them in groups of 1 cm size intervals. The study shows systematic...

  14. Clinical and cytogenetic features of a population-based consecutive series of 285 pediatric T-cell acute lymphoblastic leukemias: rare T-cell receptor gene rearrangements are associated with poor outcome

    DEFF Research Database (Denmark)

    Karrman, Kristina; Forestier, Erik; Heyman, Mats;

    2009-01-01

    Clinical characteristics and cytogenetic aberrations were ascertained and reviewed in a population-based consecutive series of 285 pediatric T-cell acute lymphoblastic leukemias (T-ALLs) diagnosed between 1992 and 2006 in the Nordic countries. Informative karyotypic results were obtained in 249 (...

  15. Evaluation of pulsatility index and diameter of the jugular vein and superficial body temperature as physiological indices of temperament in weaned beef calves: relationship with serum cortisol concentrations, rectal temp..

    Science.gov (United States)

    The relationship between temperament, pulsatility index and diameter of the jugular vein, and body temperature was assessed in Angus crossbred calves (262±24.9 days old). Temperament scores were used to classify calves as calm (n=31), intermediate (n=32), or temperamental (n=28). Blood samples were ...

  16. "Sa oled mul teine" : teisesusest eesti kultuuri eneseanalüüsis / Aare Pilv

    Index Scriptorium Estoniae

    Pilv, Aare, 1976-

    2008-01-01

    Kolmest eesti kultuuri eneseanalüüsi kontseptsioonist: "katkestus" (Hasso Krull), "eksistentsialistlik absurdiprojekt" (Jaan Undusk), "enesekolonisatsioon" (Tiit Hennoste). Poleemikat T. Hennoste enesekolonisatsiooni teooriaga (olulisim tekst selle kohta on 2006. a. avaldatud artikkel "Noor-Eesti kui lõpetamata enesekoloniseerimisprojekt"). Sisaldab bibliograafiat. Autorist lk. 249

  17. Sex Differences in the Expression of Depression in Adolescents.

    Science.gov (United States)

    Baron, Pierre; Joly, Elisabeth

    1988-01-01

    Examination of 249 Quebec adolescents on the Beck Depression Inventory (BDI) revealed in 67.8 percent of the cases that depressed males show a symptomatology characterized by irritability, work inhibition, social withdrawal and sleep disturbance. Depressed females present symptoms characterized by body image distortion, weight loss, loss of…

  18. Gclust Server: 91921 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 91921 Bsu_BSU36510=nrgA Cluster Sequences Related Sequences(249) 404 ammonium trans...porter 1 1.00e-60 0.0 0.0 0.0 0.0 3.23 0.0 Show 91921 Cluster ID 91921 Sequence ID Bsu_BSU36510=nrgA Link to

  19. Gclust Server: 192198 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 192198 DME_CG30182_28573654 Cluster Sequences - 249 CG30182: CG30182-PA 1 1.00e-99 ...0.0 0.0 0.0 0.0 0.0 12.5 Show 192198 Cluster ID 192198 Sequence ID DME_CG30182_28573654 Link to cluster sequ

  20. 42 CFR 136a.12 - Persons to whom health services will be provided.

    Science.gov (United States)

    2010-10-01

    ...) In emergencies under section 322(b) of the Public Health Service Act, 42 U.S.C. 249(b), and 42 CFR 32.111 of the regulations; (2) To Public Health Service and other Federal beneficiaries under Economy Act... 42 Public Health 1 2010-10-01 2010-10-01 false Persons to whom health services will be...

  1. Metabolic and hormonal responses of growing modern meat type chickens to fasting

    Science.gov (United States)

    The present study compared the effects of fasting on circulating concentrations of glucose, insulin and glucagon in male and female modern meat-type chickens (Ross 708) at three ages (19 d, 33 d and 47 d). Plasma concentrations of glucose were reduced by fasting with reductions of 24.9% (19-d-old),...

  2. Kala töötlemine : [andmeid aastatest 1995-2004] / Maarja Purik

    Index Scriptorium Estoniae

    Purik, Maarja

    2005-01-01

    Ilmunud ka: Agriculture and the development of rural life : overview 2004/2005. - Tallinn, 2005, lk. 49-52. Kalatöötlemise osatähtsus toiduainetööstuses moodustas 2004. a. 11,9% ja ekspordis 24,9%. Tabelid. Diagrammid

  3. "My Family and Friends": Six- to Twelve-Year-Old Children's Perceptions of Social Support.

    Science.gov (United States)

    Reid, Molly; And Others

    1989-01-01

    Investigated perceptions of social support of 249 children of 6-12 years. Data indicated that subjective impressions about social support can be measured with reliability and validity and that children understand and care about the quality and differentiation of support. (RJC)

  4. AcEST: DK955830 [AcEST

    Lifescience Database Archive (English)

    Full Text Available 7 7e-28 sp|Q8IZJ3|CPMD8_HUMAN C3 and PZP-like alpha-2-macroglobulin doma... 32 3.5 sp|Q80SU3|ZAR1_MOUSE Zygo...E+ Sbjct: 231 NPTTVVLEDKISALEGAES 249 >sp|Q8IZJ3|CPMD8_HUMAN C3 and PZP-like alph

  5. 17 CFR 240.12g-4 - Certifications of termination of registration under section 12(g).

    Science.gov (United States)

    2010-04-01

    ... Commission on Form 15 (17 CFR 249.323) that the class of securities is held of record by: (1) Less than 300... on the last day of each of the issuer's most recent three fiscal years. (b) The issuer's duty to file... suspension resulted from the issuer's merger into, or consolidation with, another issuer or issuers,...

  6. Corporate Governance Country Assessment : Chile

    OpenAIRE

    World Bank

    2003-01-01

    Chile's equity market is fairly large and successful. The market capitalization of the 249 listed firms represented 89 percent of GDP at year-end, 2001. Corporate ownership is concentrated and pyramid structures are common. Business groups/conglomerates are the predominant corporate form. Institutional investors, especially pension funds, are active equity investors. The Securities Market ...

  7. Coping with Workplace Stress: A Multiple-Group Comparison of Female Managers and Clerical Workers.

    Science.gov (United States)

    Long, Bonita C.

    1998-01-01

    A causal model of workplace stress was refined and cross-validated. Multivariate analysis and multiple-group structural equation modeling were used to investigate the effects of social roles on patterns of coping with workplace stress and job satisfaction. Differences found between managers (n=249) and clerical workers (n=214) suggest power and…

  8. Generation of a Saturated Genetic Recombination Map for Avocado (Persea americana)

    Science.gov (United States)

    Two large mapping populations of avocado consisting of 1582 trees were genotyped with 5050 SNP markers from transcribed genes using an Illumina Infinium SNP chip. A Florida mapping population consisted of 527 progeny from 'Tonnage' x 'Simmonds' and 249 from 'Simmonds' x 'Tonnage'. A California map...

  9. Schizopora phellinoides in the Netherlands

    NARCIS (Netherlands)

    Laan, van der H.F.

    1976-01-01

    Poria phellinoides Pilát in Bull. Soc. mycol. Fr. 51: 383. 1935 — Poria pseudoobducens Pilát in Sb. nár. Mus. Praze 9B (2) (Bot. I): 107 1953 — Xylodon versiporus (Pers.) Bond. var. microporus Komarova in Bot. Mater. Inst. spor. Rast 12: 249. 1959. — Schizopora phellinoides (Pilát) Domanski in Acta

  10. 77 FR 45373 - Certain Semiconductor Chips and Products Containing Same; Termination of the Investigation With a...

    Science.gov (United States)

    2012-07-31

    ... semiconductor chips and products containing the same. 76 FR 384 (Jan. 4, 2011). The complaint alleged the... ID in its entirety. 77 FR 27,249 (May 9, 2012). The notice of review asked the parties to brief... COMMISSION Certain Semiconductor Chips and Products Containing Same; Termination of the Investigation With...

  11. 75 FR 64120 - Technical Amendments to Forms N-CSR and N-SAR in Connection With the Comprehensive Iran Sanctions...

    Science.gov (United States)

    2010-10-19

    ... COMMISSION 17 CFR Parts 249 and 274 Technical Amendments to Forms N-CSR and N-SAR in Connection With the... adopting technical amendments to Forms N-CSR and N-SAR under the Securities Exchange Act of 1934 and the... Securities and Exchange Commission (``Commission'') is adopting technical amendments to Form N-CSR \\1\\...

  12. Gclust Server: 92012 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 92012 NGR_4263 Cluster Sequences Related Sequences(249) 181 gw1.16.122.1; no annota...tion 1 1.00e-99 0.0 11.11 0.0 0.0 0.0 0.0 Show 92012 Cluster ID 92012 Sequence ID NGR_4263 Link to cluster s

  13. AcEST: DK946532 [AcEST

    Lifescience Database Archive (English)

    Full Text Available FV Structural polyprotein OS=Barmah forest virus... 29 6.3 >sp|Q12594|DMAW_CLAFS ...+ + + C++ PPS S L HF Sbjct: 218 HCAVSTTHQTPDWFPLLCVQSPPSTSPFLGHF 249 >sp|P89946|POLS_BFV Structural polyprotein OS=Barmah forest

  14. Sobre la historia de la traducción en España

    Directory of Open Access Journals (Sweden)

    Manuel Bruña Cuevas

    2011-01-01

    Full Text Available A propósito de la obra de Francisco Lafarga y Luis Pegenaute (eds., Diccionario histórico de la traducción en España (Madrid, Gredos, 2009; 1232 páginas. ISBN: 978-84-249-3626-6.

  15. Task Value Profiles across Subjects and Aspirations to Physical and IT-Related Sciences in the United States and Finland

    Science.gov (United States)

    Chow, Angela; Eccles, Jacquelynne S.; Salmela-Aro, Katariina

    2012-01-01

    Two independent studies were conducted to extend previous research by examining the associations between task value priority patterns across school subjects and aspirations toward the physical and information technology- (IT-) related sciences. Study 1 measured task values of a sample of 10th graders in the United States (N = 249) across (a)…

  16. 肿瘤标志对煤矿工人尘肺并发肺癌的鉴别诊断价值%Differential diagnosis of pneumoconiosis complicated with lung cancer by detection of tumor markers in coal miner

    Institute of Scientific and Technical Information of China (English)

    万传远

    2011-01-01

    OBJECTIVE: To investigate the diagnostic value of serum tumor markers for pneumoconiosis complicated with lung cancer. METHODS: The serum tumor markers Cy-fra21-l, NSE, CEA and CA125 were measured with electrochemistry iluminescence in 98 cases of pneumoconiosis complicated with lung cancer, 151 cases of pneumoconiosis and 252 healthy coal miners. RESULTS: All the 4 tumor markers in lung cancer patients were significantly higher than that in pneumoconiosis and healthy controls (P< 0.001). The levels of CEA and CA125 in adenocarcinoma, Cyfra21-1 in squamous carcinoma, NSE in small cell lung cancer were higher than other pathological types of lung cancer statistically CP<0. 001). The accuracy of single marker to discriminate complicated with lung cancer and pneumoconiosis was 81. 1% (202/249), 71. L%(177/249), 71. 5%(178/249), 74. 7% (186/249), respectively. Combined detection was 87. 6% (218/249). CONCLUSION: The combined detection of Cyfra21-1, NSE, CEA, and CA125 is useful for differential diagnosis of pneumoconiosis complicated with lung cancer, and helpful to judge pathological types of lung cancer.%目的:探讨肿瘤标志在煤矿工人尘肺并发肺癌中的诊断价值.方法:应用电化学发光技术,检测98例尘肺并发肺癌患者、151例尘肺患者和252位健康煤矿工人血清细胞角蛋白21-1(Cyfra21-1)、神经元特异性烯醇化酶(NSE)、癌胚抗原(CEA)以及糖类抗原125(CA125)水平.结果:尘肺并发肺癌患者血清Cyfra21-1、NSE、CEA和CA125表达水平均显著高于患尘肺或健康煤矿工人,P<0.001.其中腺癌的CEA及CAt25水平、鳞癌的Cyfra21-1表达水平以及小细胞癌的NSE表达水平比其他2种类型均高,且差异有统计学意义,P<0.001.以上单项肿瘤标志鉴别诊断尘肺和尘肺并发肺癌的准确性分别达到81.1%(202/249)、71.1% (177/249)、71.5% (178/249)和74.7% (186/249),联合检测准确性达87.6%(218/249).结论:Cyfra21-1、NSE、CEA 和CA125联合检测

  17. Epidemiology of Complex Congenital Heart Disease in Defective Stillbirth Fetus%复杂性先天性心脏病在非活产缺陷儿中的发生状况

    Institute of Scientific and Technical Information of China (English)

    欧艳秋; 刘小清; 麦劲壮; 韩凤珍; 陈寄梅; 潘微; 庄建

    2012-01-01

    Objective:To investigate the prevalence and diagnosis of complex congenital heart disease( CCHD )in defective stillbirth fetus. Methods : We retrospectively studied 14342 fetuses and new born babies in our hospital from 2005 to 2010,that including 249 cases of defective stillbirth. All diagnosis was confirmed by fetal echocardiography. The defective rate and the component ratio of CCHD in stillbirth fetuses were analyzed. Results:The total detective rate of CHD in all birth was 10. 95‰( 157/14342 ),the detective rate in defective stillbirth was 1. 74%( 249/14342 )and CCHD in defective stillbirth was 17. 27%( 43/249 ). The CCHD occurrence as complete atrioventricular septal defect in 52‰( 13/249 ) cases,double outlet of right ventricle in 36‰ cases( 9/249 ), single ventricle in 32‰ cases( 8/ 249 ) and great artery conversion in 24‰ cases( 6/249 ). 95. 35% parents of CCHD fetuses chose to terminate the pregnancy. The detective rate for CCHD was higher in female fetuses than that in male( 30. 38% vs. 14. 55% ,P = 0. 0086 ). The average diagnosis time for CCHD fetuses was( 26. 9±4. 9 )weeks of gestation,and 67. 44% of diagnosis was made between 20 ~ 30 weeks of gestation. Conclusion:There was a high detective rate for CCHD in defective stillbirth. Fetal echocardiography was an effective and helpful method for CCHD diagnosis in fetuses.%目的:了解复杂性先天性心脏病(CCHD)在非活产缺陷儿中的检出和诊断情况.方法:通过病历回顾的方法选取我院2005-01-01 至2010-12-31胎儿及新生儿14 342例,非活产缺陷儿249例.主要诊断手段为胎儿超声心动图.分析CCHD在非活产缺陷儿中的检出率及构成比例.结果:14 342例胎儿及新生儿的先天性心脏病总检出率为10.95‰(157例),非活产缺陷儿的249例(1.74%),CCHD 43例占非活产缺陷儿的17.27%.43例中CCHD的亚型比例分布依次是完全性房室间隔缺损52‰(13例);右心室双出口36‰(9例)、单心室32‰(8

  18. Identification of a disulfide bridge important for transport function of SNAT4 neutral amino acid transporter.

    Directory of Open Access Journals (Sweden)

    Rugmani Padmanabhan Iyer

    Full Text Available SNAT4 is a member of system N/A amino acid transport family that primarily expresses in liver and muscles and mediates the transport of L-alanine. However, little is known about the structure and function of the SNAT family of transporters. In this study, we showed a dose-dependent inhibition in transporter activity of SNAT4 with the treatment of reducing agents, dithiothreitol (DTT and Tris(2-carboxyethylphosphine (TCEP, indicating the possible involvement of disulfide bridge(s. Mutation of residue Cys-232, and the two highly conserved residues Cys-249 and Cys-321, compromised the transport function of SNAT4. However, this reduction was not caused by the decrease of SNAT4 on the cell surface since the cysteine-null mutant generated by replacing all five cysteines with alanine was equally capable of being expressed on the cell surface as wild-type SNAT4. Interestingly, by retaining two cysteine residues, 249 and 321, a significant level of L-alanine uptake was restored, indicating the possible formation of disulfide bond between these two conserved residues. Biotinylation crosslinking of free thiol groups with MTSEA-biotin provided direct evidence for the existence of a disulfide bridge between Cys-249 and Cys-321. Moreover, in the presence of DTT or TCEP, transport activity of the mutant retaining Cys-249 and Cys-321 was reduced in a dose-dependent manner and this reduction is gradually recovered with increased concentration of H2O2. Disruption of the disulfide bridge also decreased the transport of L-arginine, but to a lesser degree than that of L-alanine. Together, these results suggest that cysteine residues 249 and 321 form a disulfide bridge, which plays an important role in substrate transport but has no effect on trafficking of SNAT4 to the cell surface.

  19. Proton Single-Particle States In The Heaviest Actinide Nuclei

    International Nuclear Information System (INIS)

    The level structure of 249Bk has been investigated by measuring the γ-ray spectra following the α decay of a chemically and isotopically pure 253Es sample. Alpha-gamma coincidence measurement was performed using a Si detector for α particles and a 25% Ge detector for γ rays. A gamma-gamma coincidence measurement was performed with the Gammasphere spectrometer. The Es sample was obtained by extracting the 253Es which grew in a 253Cf source material produced in the High Flux Isotope Reactor (HFIR) at Oak Ridge National Laboratory. Additional information on the 249Bk levels was obtained from the study of γ rays produced in the β- decay of 249Cm. The 249Cm sample was produced by neutron irradiation of 248Cm. Using the results of the present study and the results of previous 248Cm(α,t) and 248Cm(3He,d) reaction spectra, the following single-particle states have been identified in 249Bk: 7/2+[633], 0.0 keV; 3/2-[521], 8.78 keV; 1/2+[400], 377.55 keV: 5/2+[642], 389.17 keV; 1/2-[530], 569.19 keV; 1/2-[521], 643.0 keV; 5/2-[523], 672.8 keV; 9/2+[624], 1075.1 keV. Four vibrational bands were identified at 767.9, 932.2, 1150.7 and 1223.0 keV with tentative assignments of {7/2+[633]x1-}9/2-, {7/2+[633]x0-}7/2-, {7/2+[633]x1-}5/2- and {7/2+[633]x0+}7/2+, respectively

  20. Single amino acid mutation alters thermostability of the alkaline protease from Bacillus pumilus: thermodynamics and temperature dependence.

    Science.gov (United States)

    Huang, Rong; Yang, Qingjun; Feng, Hong

    2015-02-01

    Dehairing alkaline protease (DHAP) from Bacillus pumilus BA06 has been demonstrated to have high catalytic efficiency and good thermostability, with potential application in leather processing. In order to get insights into its catalytic mechanism, two mutants with single amino acid substitution according to the homology modeling and multiple sequence alignment were characterized in thermodynamics of thermal denaturation and temperature dependence of substrate hydrolysis. The results showed that both mutants of V149I and R249E have a systematic increase in catalytic efficiency (kcat/Km) in a wide range of temperatures, mainly due to an increase of k1 (substrate diffusion) and k2 (acylation) for V149I and of k2 and k3 (deacylation) for R249E. In comparison with the wild-type DHAP, the thermostability is increased for V149I and decreased for R249E. Thermodynamic analysis indicated that the free energy (ΔGa°) of activation for thermal denaturation may govern the thermostability. The value of ΔGa° is increased for V149I and decreased for R249E. Based on these data and the structural modeling, it is suggested that substitution of Val149 with Ile may disturb the local flexibility in the substrate-binding pocket, leading to enhancement of binding affinity for the substrate. In contrast, substitution of Arg249 with Glu leads to interruption of interaction with the C-terminal of enzyme, thus resulting in less thermostability. This study indicates that amino acid residues in the active center or in the substrate-binding pocket may disturb the catalytic process and can be selected as the target for protein engineering in the bacterial alkaline proteases. PMID:25534779

  1. Clinic application of serum low-density lipoprotein cholesterol level in predicting expansion hematoma in elderly male patients with acute hypertensive intracerebral hemorrhage%血清LDL-C水平对老年男性高血压性脑出血血肿扩大的预测作用

    Institute of Scientific and Technical Information of China (English)

    周红霞; 刘首峰; 李玉旺; 王欣; 徐小林

    2015-01-01

    Objective To investigate whether serum level of low-density lipoprotein cholesterol can predict the expan⁃sion of hemorrhage growth in elderly male patients with acute hypertensive intracerebral hemorrhage. Methods Patients (n=108) who visited our hospital with from June 2012 until May 2014 spontaneous hypertensive intracerebral hemorrhage with⁃in 6 hours of onset which is confirmed by initial computed tomography (CT) were sent to repeated CT within 24 hours of on⁃set. All selected patients were divided into the LDL-C≥2.49 mmol/L group and LDL-C<2.49 mmol/L group. Clinical data of these 2 groups were compared and the relationships of hematoma growth and its risk factors were analyzed. Results Baseline blood pressure, the level of blood glucose, PT, APTT, FIB, PLT and hemorrhage volume did not differ significantly between the LDL-C≥2.49 mmol/L group and LDL-C<2.49 mmol/L group. The ratio of hemorrhage growth in LDL-C<2.49 mmol/L group was significantly higher than that in LDL-C≥2.49 mmol/L group (34.21%vs 11.43%). Multiple logistic regres⁃sion analysis showed that LDL-C<2.49 mmol/L was the only risk factor contribute to hemorrhage growth. Conclusion Pa⁃tients with LDL-C<2.49 mmol/L in acute intracerebral hemorrhage are of high risk of hemorrhage growth so early attention and appropriate procedure are needed to prevent or slow its growth.%目的:探讨血清低密度脂蛋白胆固醇(LDL-C)水平对老年男性高血压性脑出血急性期血肿扩大有无预测作用。方法收集我院2012年6月—2014年5月发病6 h以内的老年男性高血压性脑出血患者108例,按发病时LDL-C水平分为LDL-C<2.49 mmol/L组和LDL-C≥2.49 mmol/L组,对2组患者入院时的收缩压(SBP)、舒张压(DBP)、血糖水平、凝血酶原时间(PT)、部分活化凝血酶时间(APTT)、纤维蛋白原(FIB)、血小板计数、血肿体积进行对比分析,并于发病24 h复查头CT了解2组血肿扩大情况并进

  2. Evaluation of anticonvulsant actions of dibromophenyl enaminones using in vitro and in vivo seizure models.

    Directory of Open Access Journals (Sweden)

    Mohamed G Qaddoumi

    Full Text Available Epilepsy and other seizure disorders are not adequately managed with currently available drugs. We recently synthesized a series of dibromophenyl enaminones and demonstrated that AK6 and E249 were equipotent to previous analogs but more efficacious in suppressing neuronal excitation. Here we examined the actions of these lead compounds on in vitro and in vivo seizure models. In vitro seizures were induced in the hippocampal slice chemically (zero Mg2+ buffer and picrotoxin and electrically using patterned high frequency stimulation (HFS of afferents. In vivo seizures were induced in rats using the 6 Hz and the maximal electroshock models. AK6 (10 µM and E249 (10 µM depressed the amplitude of population spikes recorded in area CA1 of the hippocampus by -50.5±4.3% and -40.1±3.1% respectively, with partial recovery after washout. In the zero Mg2+ model, AK6 (10 µM depressed multiple population spiking (mPS by -59.3±6.9% and spontaneous bursts (SBs by -65.9±7.2% and in the picrotoxin-model by -43.3±7.2% and -50.0±8.3%, respectively. Likewise, E249 (10 µM depressed the zero-Mg2+-induced mPS by -48.8±9.5% and SBs by -55.8±15.5%, and in the picrotoxin model by -37.1±5.5% and -56.5±11.4%, respectively. They both suppressed post-HFS induced afterdischarges and SBs. AK6 and E249 dose-dependently protected rats in maximal electroshock and 6 Hz models of in vivo seizures after 30 min pretreatment. Their level of protection in both models was similar to that obtained with phenytoin Finally, while AK6 had no effect on locomotion in rats, phenytoin significantly decreased locomotion. AK6 and E249, suppressed in vitro and in vivo seizures to a similar extent. Their in vivo activities are comparable with but not superior to phenytoin. The most efficacious, AK6 produced no locomotor suppression while phenytoin did. Thus, AK6 and E249 may be excellent candidates for further investigation as potential agents for the treatment of epilepsy syndromes

  3. NUCLEAR SPECTROSCOPIC STUDIES OF SOME VERY HEAVY ODD-MASS NUCLIDES

    Energy Technology Data Exchange (ETDEWEB)

    Ahmad, Irshad

    1966-09-20

    The nuclear radiations of nuclides: U{sup 233}, Pu{sup 239}, Bk{sup 243}, Bk{sup 244}, Bk{sup 245}, Bk{sup 246}, Bk{sup 249}, Cf{sup 249}, and Fm{sup 255} were investigated with high-resolution spectrometers. The {alpha}-particle spectra of all nuclides except Bk{sup 249} were measured with 6 mm diameter surface-barrier detectors. Bk{sup 249} {alpha}-particles were analyzed with a double-focusing magnetic spectrograph. The {gamma}-singles were examined with the recently developed Ge(Li) and Si(Li) detectors coupled with very-low noise 'internal FET' preamplifiers. Weak alpha groups were observed in coincidence with {gamma}-rays, detected with a NaI(Tl) scintillation spectrometer. To improve the over-all coincidence efficiency a new coincidence apparatus was designed and built. This instrument consisted of a cooled 4.5 cm diameter semiconductor detector for {alpha}-particle detection and a 3 cm diameter by 2.7 cm long Ge(Li) detector for {gamma}-ray analysis. The Ge(Li) detector could also be replaced with a NaI(Tl) detector. Cf{sup 249} conversion electrons were measured with a cooled Si(Li) detector coupled with an internal FET preamplifier. On the basis of the present work and previous information, energy-level diagrams of the daughter nuclei have been constructed. The levels have been grouped into rotational bands built on Nilsson single-particle states. Because of identification of several rotational members of the bands, definite Nilsson quantum number assignments have been made in most cases. The alpha intensity calculations of Poggenburg were found quite helpful in making these assignments. A strong Coriolis effect was observed in the Am{sup 245} levels populated by the alpha groups of Bk{sup 249}. Calculations were made with Nilsson wave-functions, and these were found to agree with the experimental results. The Coriolis interaction was found important in almost all cases; the effect was very noticeable in the level spacings between the rotational

  4. Disperse Red 1 (textile dye) induces cytotoxic and genotoxic effects in mouse germ cells.

    Science.gov (United States)

    Fernandes, Fábio Henrique; Bustos-Obregon, Eduardo; Salvadori, Daisy Maria Fávero

    2015-06-01

    Disperse Red 1 (DR1), which is widely used in the textile industry, is an azo dye that contributes to the toxicity and pollution of wastewater. To assess the toxic effects of DR1 on reproduction, sexually mature male mice (Mus musculus, strain CF-1) were orally (gavage) treated with single doses of the compound at 20, 100 and 500 mg/kg body weight. Testicular features and sperm parameters were evaluated 8.3, 16.6 and 24.9 days after treatments. In addition to testicular toxicity caused by the dye, the data clearly showed an increased frequency of sperm with abnormal morphology and decreased fertility. An increased amount of DNA damage was also detected in testis cells 16.6 and 24.9 days after treatments with 100 and 500 mg/kg. This study demonstrated the toxic and genotoxic effects of DR1, indicating the harmful activity of this dye on reproductive health.

  5. 血清低密度脂蛋白与急性出血性卒中患者病情的相关性分析%Analysis of relation between serum low density lipoprotein cholesterol and the pathogenetic condition of pa-tients with acute hemorrhagic stroke

    Institute of Scientific and Technical Information of China (English)

    邬莹

    2015-01-01

    Objective To investigate the relation between serum low density lipoprotein cholesterol(LDL‐C)and the patho‐genetic condition of patients with acute hemorrhagic stroke. Methods The clinical data of 100 cases of patients with acute hem‐orrhagic stroke in our hospital from January 2010 to January 2013 were analyzed retrospectively. All the patients were divided into 43 cases of LDL‐C0.05).The incidence of hematoma enlargement of LDL‐C<2.49 mmol/L group was significantly increased, compared with LDL‐C≥2.49 mmol/L group, the difference was statistically significant(P<0.05), and the level of LDL‐C in patients with hematoma enlargement was significantly lower than that of patients without hematoma enlargement, the difference was statistically signifi‐cant(P<0.05). Conclusion The pathogenetic condition of patients with acute hemorrhagic stroke is related with the serum LDL‐C level, patients with LDL‐C<2.49 mmol/L are prone to occur hematoma enlargement. It should pay much attention to the detection of serum LDL‐C on admission, w hich is helpful to predict the pathogenetic condition.%目的探讨血清低密度脂蛋白(LDL‐C)和急性出血性卒中患者病情的关系。方法100例急性出血性卒中患者按照入院时LDL‐C水平分成LDL‐C<2.49 mmol/L组43例与LDL‐C≥2.49 mmol/L组57例,分析急性出血性卒中患者病情程度与LDL‐C水平的相关性。结果2组患者在凝血酶原时间、收缩压、舒张压、血肿大小、纤维蛋白原、部分活化凝血酶时间、血小板数量以及血糖等生化指标水平比较差异无统计学意义(P>0.05);LDL‐C<2.49 mmol/L组血肿扩大发生率显著上升,与LDL‐C≥2.49 mmol/L组相比,差异有统计学意义(P<0.05),且血肿扩大患者的LDL‐C水平显著低于无血肿扩大患者,差异有统计学意义(P<0.05)。结论急性出血性卒中患者病情与血清LDL‐C水平有关,LDL‐C<2.49 mmol

  6. Spectrophotometric determination of tranexamic acid using vanillin

    Institute of Scientific and Technical Information of China (English)

    EM.A.Rind; M.G.H.Laghari; A.H.Memon; U.R.Mughal; F. Almani; N.Me-mon; M.Y.Khuhawar; M.L.Maheshwari

    2009-01-01

    A new spectrophotometric method has been examined for the determination of the tranexamic acid (TA)by derivatization with vanillin(VAN).The molar absorptivity of TA was calculated 25 160 L·mol-1·cm-1at λ max 354 nm and obeyed the Beer's law within 0.5-2.5 μg·mL-1.The color reaction was highly stable and didnot show any change in absorbance up to 24 h.The method was applied for the analysis of TA from capsules,injections and tooth pastes.The amounts of TA found in capsules,injections and tooth pastes of various pharmaceutical companies were observed with 249.0-250.9 mg/capsule,249.3-250.7 mg/injection and 0.048%-0.049%in tooth pastes with relative standard deviation(RSD)0.2%-5.0%(n=3).

  7. Recent progress in 8igenomic research of liver cancer

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Along the course of occurrence and development of liver cancer,the corresponding somatic cells accumulate some important genetic variations.These variations may be divided into two categories.For the genetic changes closely related to etiology of liver cancer,the well-known cases include insertion and integration of the hepatitis B virus(HBV) DNA after infection,and mutations at site 249 of the tumor suppressor gene p53 induced by exposure to aflatoxin B1.The secondary genetic changes include amplification and deletion of certain chromosome regions,mutations in p53 at the sites other than 249,as well as the mutational activation of the Wnt/β-catenin signal pathway.The tumor cells with these genetic variations may gradually become the dominant clones under evolutionary selection.Besides,identification of genetic susceptible against risk of liver malignancy is also an important aspect of research in this field.

  8. Recent progress in 8igenomic research of liver cancer

    Institute of Scientific and Technical Information of China (English)

    HAN ZeGuang

    2009-01-01

    Along the course of occurrence and development of liver cancer, the corresponding somatic cells ac-cumulate some important genetic variations. These variations may be divided into two categories. For the genetic changes closely related to etiology of liver cancer, the well-known cases include insertion and integration of the hepatitis B virus (HBV) DNA after infection, and mutations at site 249 of the tumor suppressor gene p53 induced by exposure to aflatoxin B1. The secondary genetic changes include amplification and deletion of certain chromosome regions, mutations in p53 at the sites other than 249, as well as the mutational activation of the Wnt/β-catenin signal pathway. The tumor cells with these genetic variations may gradually become the dominant clones under evolutionary selection. Besides, identification of genetic susceptible against risk of liver malignancy is also an important aspect of re-search in this field.

  9. An integrated catalog of reference genes in the human gut microbiome

    DEFF Research Database (Denmark)

    Li, Junhua; Jia, Huijue; Cai, Xianghang;

    2014-01-01

    Many analyses of the human gut microbiome depend on a catalog of reference genes. Existing catalogs for the human gut microbiome are based on samples from single cohorts or on reference genomes or protein sequences, which limits coverage of global microbiome diversity. Here we combined 249 newly ...... signatures. This expanded catalog should facilitate quantitative characterization of metagenomic, metatranscriptomic and metaproteomic data from the gut microbiome to understand its variation across populations in human health and disease.......Many analyses of the human gut microbiome depend on a catalog of reference genes. Existing catalogs for the human gut microbiome are based on samples from single cohorts or on reference genomes or protein sequences, which limits coverage of global microbiome diversity. Here we combined 249 newly...

  10. Determination of boron by ICP-AES in normal and malignant cells incubated 'in vitro' with fructose 10BPA

    International Nuclear Information System (INIS)

    This paper describes the development and optimization of methodology for total boron concentration in cell cultures coming from fixation and accumulation of this element by normal and malignant cells. On account of sample mass and low volume resulting from dilution, generally about 1 mL, a procedure for automatic injection of micro volumes was designed, developed and optimized. Iron interference was carefully studied. Linear calibration curves were obtained for 50 to 2500 ng B/mL range. Determination limits were 10 and 20 ng B/mL for B 249.772 nm and 249.677 nm, respectively. Repeatability, expressed as relative standard deviation was better than 5% for a 100 ng B/mL. Recovery of analyte added to real samples ranged between 95 and 103%. The method was applied to studies on F-98 cells (rat glioma) and normal glia in BNCT project frame. (author)

  11. Fire behaviour of EPS ETICS on concrete or masonry facades

    OpenAIRE

    Afipeb; Sipev; Snmi

    2016-01-01

    In France, fire safety of facades for establishments open to the public has been governed by the Technical Instruction n∘249 since 1982; its current version was made regulatory on May 24th, 2010. Considering this revision, the Ministry of Interior requested industrials firms to revalidate the fire behaviour of their external insulation systems through testing. AFIPEB, SIPEV and SNMI decided therefore to launch a test campaign. After a preliminary analysis of Single Burning Item (SBI) data rel...

  12. The relationship between the rate of melatonin excretion and sleep consolidation for locomotive engineers in natural sleep settings

    OpenAIRE

    Roach, Gregory D.; Reid, Kathryn J.; Ferguson, Sally; Dawson, Drew

    2006-01-01

    Background: The aim of the study was to examine the role that melatonin production plays in the regulation of sleep consolidation in a population of shiftworkers working and sleeping in their natural environments.Methods: 253 locomotive engineers (249 male, 4 female, mean age = 39.7 years) participated in the study for a 2-week period whilst working their normal roster patterns. Participants recorded details for all sleep periods in a sleep diary and collected urine samples during each day's ...

  13. Polygenic risk for externalizing disorders: Gene-by-development and gene-by-environment effects in adolescents and young adults

    OpenAIRE

    Salvatore, Jessica E.; Aliev, Fazil; Bucholz, Kathleen; Agrawal, Arpana; Hesselbrock, Victor; Hesselbrock, Michie; Bauer, Lance; Kuperman, Samuel; Marc A Schuckit; Kramer, John; Edenberg, Howard J.; Foroud, Tatiana M.; Dick, Danielle M

    2014-01-01

    In this project, we aimed to bring large-scale gene identification findings into a developmental psychopathology framework. Using a family-based sample, we tested whether polygenic scores for externalizing disorders—based on single nucleotide polymorphism weights derived from genome-wide association study results in adults (n = 1,249)—predicted externalizing disorders, subclinical externalizing behavior, and impulsivity-related traits adolescents (n = 248) and young adults (n = 207), and whet...

  14. Preschool and Educational Technology: Evaluating a Tablet-Based Math Curriculum in Mexico City

    OpenAIRE

    Garduno, Ana Eugenia

    2016-01-01

    This study examines the effect of an intervention called Native Numbers on the development of number sense and quantitative skills in low-SES preschool children (ages 5 to 6) in Mexico City, using a randomized control trial (RCT). Native Numbers (NN) is a math curriculum built as an application for iPads that includes activities on number concepts, relations, ordering and counting. The study was conducted in 2014, with eight participating schools and an analytic sample of 249 students. The in...

  15. Drug: D05258 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available gonadotropin receptor agonist [HSA:3973] [KO:K04248]; follicle stimulating hormone receptor agonist [HSA:249...O URINARY SYSTEM AND SEX HORMONES G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM G03G GONADOTROPINS AND OTHER OVULATION STIMU...973] [KO:K04248] Serum gonadotrophin [ATC:03GA03] D05258 Serum gonadotrophin (JP16) Follicle stimulating hormone follicle stimu

  16. Non-Spherical Gravitational Collapse of Strange Quark Matter

    Institute of Scientific and Technical Information of China (English)

    Zade S S; Patil K D; Mulkalwar P N

    2008-01-01

    We study the non-spherical gravitational collapse of the strange quark null fluid.The interesting feature which emerges is that the non-spherical collapse of charged strange quark matter leads to a naked singularity whereas the gravitational collapse of neutral quark matter proceeds to form a black hole.We extend the earlier work of Harko and Cheng[Phys.Lett.A 266 (2000) 249]to the non-spherical case.

  17. Real-time operating mode with DSSSD detector to search for short correlation ER-alpha chains

    CERN Document Server

    Tsyganov, Yury

    2015-01-01

    Real-time PC based algorithm is developed for DSSSD detector. Complete fusion nuclear reaction natYb+48Ca->217Th is used to test this algorithm at 48Ca beam. Example of successful application of a former algorithm for resistive strip PIPS detector in 249Bk+48Ca nuclear reaction is presented too. Case of alpha-alpha correlations is also under brief consideration.

  18. 2006年欧洲萨托利防务展轻武器撷英(下)

    Institute of Scientific and Technical Information of China (English)

    王正和(编译)

    2006-01-01

    IWI公司的伽利尔狙击步枪(配用新型枪托);美国AAI公司的LSAT计划轻机枪概念模型;比利时FN米尼米7.62mm轻机枪;美国M240 E6钛通用机枪;美国新型M249班用机枪。

  19. The chemical characteristics of soil which determine phosphorus partitioning in highly calcareous soils

    OpenAIRE

    ANA TOPALOVIC; LIDIJA B. PFENDT; NATALIJA PEROVIC; DRAGANA DJORDJEVIC; SNEZANA TRIFUNOVIC; PETAR A. PFENDT

    2006-01-01

    Phosphorus fractions from three highly calcareous soils (average, 24.9 ± 4.8 %CO32-) from sampling sites with aMediterranean climate were isolated by sequential extraction. In order to provide a more reliable basis for the definition of the obtained P-fractions, principal component analysis was applied and from the chemical characteristics of the 14 investigated soils, those characteristics which define the content and association features of the P-fractions were assessed. The soils are chara...

  20. Gas scrubbers used in pollution control. Volume 4. 1977-March, 1980 (citations from the Engineering Index Data Base). Report for 1977-Mar 80

    Energy Technology Data Exchange (ETDEWEB)

    Cavagnaro, D.M.

    1980-03-01

    The citations from a worldwide literature survey relate to particle and gas scrubbers. The reports discuss design, performance, gas flow characteristics, and chemistry of the pollutants. Pollution control of SO2, NOx, CO, CO2, hydrocarbons, and particles is considered. (This updated bibliography contains 249 abstracts, 84 of which are new entries to the previous edition.) Volume 2, 1974-1975, NTIS/PS-77/0192, and Volume 3, 1976, NTIS/PS-78/0255.

  1. Design of an electronically tunable millimeter wave Gyrotron Backward Wave Oscillator

    Energy Technology Data Exchange (ETDEWEB)

    Caplan, M.

    1987-01-01

    A non-linear self-consistent computer simulation code is used to analyze the saturated output of the Gyrotron Backward Wave Oscillator (Gyro BWO) which can be used as a tunable driver for a 250 GHz FEL amplifier. Simulations show that the Gyrotron BWO using a Pierce/Wiggler gun configuration can produce at least 10 kW of microwave power over the range 249 GHz to 265 GHz by varying beam voltage alone.

  2. Quality improvement practices used by teaching versus non-teaching trauma centres: analysis of a multinational survey of adult trauma centres in the United States, Canada, Australia, and New Zealand

    OpenAIRE

    Chaubey, Vikas P; Roberts, Derek J.; Ferri, Mauricio B; Bobrovitz, Niklas H; Stelfox, Henry T

    2014-01-01

    Background Although studies have suggested that a relationship exists between hospital teaching status and quality improvement activities, it is unknown whether this relationship exists for trauma centres. Methods We surveyed 249 adult trauma centres in the United States, Canada, Australia, and New Zealand (76% response rate) regarding their quality improvement programs. Trauma centres were stratified into two groups (teaching [academic-based or –affiliated] versus non-teaching) and their qua...

  3. GEOCHRONOMETRY & ISOTOPE GEOLOGY

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    <正>20080453 Gu Zhaoyan(Institute of Geology and Geophysics,Chinese Academy of Sciences,Beijing 100029);Guo Zhengtang 10 Be Concentration Relation to Chemical Compositions of Chinese Loess and Red Clay as a Potential Dating Method(Quaternary Sciences,ISSN1001-7410,CN11-2708/P,26(2),2006,p.244-249,3 illus.,1 table,21 refs.)

  4. Coset spaces and Einstein manifolds with l-conformal Galilei symmetry

    CERN Document Server

    Chernyavsky, Dmitry

    2016-01-01

    The group theoretic construction is applied to construct a novel dynamical realization of the $l$--conformal Galilei group in terms of geodesic equations on the coset space. A peculiar feature of the geodesics is that all their integrals of motion, including the accelerations, are functionally independent. The analysis in the recent work [Phys. Lett. B 754 (2016) 249] is extended to construct the Einstein metrics with the $l$--conformal Galilei isometry group.

  5. Contribución al catálogo de los hongos de Madeira (Portugal).

    OpenAIRE

    Calonge, F.D.; Menezes de Sequeira, M.

    2003-01-01

    [EN] As a result ofa two months stay in Madeira, Portugal, 747 samples offungi were col1ected, being 249 the identified taxa. A catalogue ofthem is presented here. The main object ofthis study is to search the fungi growing in Laurus forests (Iaurisylva), which takes a 30%, approximately, ofthe island territory, while the rest ofthe island is occupied by trees introduced from America and Europe. Thus, most fungi species are those common in both continents. Among the more interested ones...

  6. Survey of pesticide poisoning in Sri Lanka

    OpenAIRE

    J. Jeyaratnam; Seneviratne, R. S. de Alwis; Copplestone, J. F.

    1982-01-01

    This study included a sample survey of the clinical records of patients admitted to the different hospitals in Sri Lanka, and showed that approximately 13 000 patients are admitted to hospital annually for pesticide poisoning and that each year 1000 of them die. Suicidal attempts account for 73% of the total, and occupational and accidental poisoning accounts for 24.9%. It is recommended that urgent action be taken to minimize the extent of the problem.

  7. 12 CFR 563d.802 - Description of business.

    Science.gov (United States)

    2010-01-01

    ... return on equity and assets, item 7(d)(5), should include a line item for “dividend payout ratio...-business portion of: (1) Registration statements filed on Form 10 (item 1) (17 CFR 249.210), (2) Proxy and... Schedule 14A and item 1 of Schedule 14C) (17 CFR 240.14a-101 and 240.14c-101), and (3) Annual reports...

  8. EXAMINATION OF THE RELATIONSHIP BETWEEN SELF-COMPASSION AND AWARENESS IN INTERPERSONAL RELATION OF POLICE CADETS

    OpenAIRE

    Ruhi YİĞİT

    2012-01-01

    Abstract Main objective of this study is to reveal relationship between levels of awareness of police cadets in terms of interpersonal relations and their self-compassion .Research data has been obtained by using self-insight scale and scale of awareness in interpersonal relations. Research has been made in accordance with general scanning model. Research group consists of police cadets studying in police vocational high school located in Ereğli town of Konya.249 police cadets chosen by ...

  9. EST Table: FS938859 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FS938859 E_FL_fwgP_53D14_F_0 10/09/28 92 %/249 aa ref|NP_001037309.1| vitellogenin ...rt=VH; Flags: Precursor dbj|BAA02444.1| vitellogenin precursor [Bombyx mori] dbj|BAA06397.1| vitellogenin [B...2654|ref|XP_970210.1| PREDICTED: similar to vitellogenin [Tribolium castaneum] FS939370 fwgP ...

  10. QTL Information Table: 198 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available G249 RG418 pha Luo, L.J., Li, Z.K., Mei, H.W., Shu, Q.Y., Tabien, R., Zhong, D.B., Ying, C.S., Stansel, J.W....eeding Depression and Heterosis in Rice. II. Grain Yield Components. Genetics 158, 1755-1771. http://www.genetics.org/cgi/content/abstract/158/4/1755 ...

  11. Clinician, Society and Suicide Mountain: Reading Rogerian Doctrine of Unconditional Positive Regard (UPR)

    OpenAIRE

    Chinedum Amadi

    2013-01-01

    Carl Rogers has become a legendary personage in the mental health field. Rogers (1957) “has been cited in the literature over a thousandtimes, in professional writings originating in 36 countries” (Goldfried, 2007, p. 249). Clinicians in the behavioral health field (psychiatry, socialwork, counseling and psychology) are exposed to his teachings about human behavior. Of all the ideas propagated by Rogers, the conceptof unconditional positive regard (UPR) has been elevated to the level of a doc...

  12. 酮康唑乳膏治疗浅部真菌病疗效分析%Efficacy Analysis of Ketoconazole Treat Superficial Mycoses

    Institute of Scientific and Technical Information of China (English)

    钱青; 袁玲玲; 李月花; 翟萍

    2011-01-01

    目的:探讨酮康唑乳膏治疗皮肤浅部真菌病的临床疗效.方法:249例皮肤浅部真菌病患者采用酮康唑乳膏治疗,早晚各1次,连用2~4周,观察临床症状和体征.结果:249例皮肤浅部真菌病患者中,体股癣有效率94.7%;手足癣有效率94.3%;花斑癣有效率97.7%;皮肤念珠菌病有效率95.4%,没有发现不良反应.结论:酮康唑乳膏治疗皮肤浅部真菌病有较高的疗效.%Objective:To discuss clinical efficacy of Ketoconazole cream in the treatment of superficial mycoses.Methods:249 cases of superficial mycoses using ketoconazole cream in the treatment,twice a day, last 2 to 4 weeks,observing clinical symptoms and signs.Results:249 cases of skin in patients with superficial mycoses,efficiency of tinea corporis and cruris is 94.7%;tinea manuum and pedis is 94.3%;pityriasis versicolor isL97.7%;skin candidiasis is 95.4%,no adverse reactions.Conclusion:Ketoconazole cream in the treatment of superficial mycoses have a higher efficacy.

  13. The Relationship between Endorsing Gambling as an Escape and the Display of Gambling Problems

    OpenAIRE

    Weatherly, Jeffrey N.

    2012-01-01

    Previous research has reported a strong relationship between endorsing gambling as an escape and problem/pathological gambling as measured by the South Oaks Gambling Screen (SOGS). The present study recruited 249 university students to complete the Gambling Functional Assessment-Revised (GFA-R), which measures the function of the respondent’s gambling, as well as the SOGS and the Problem Gambling Severity Index (PGSI), which was designed to identify gambling problems in the general population...

  14. Acculturation to the global consumer culture: A generational cohort comparison

    OpenAIRE

    Carpenter, Jason; Moore, Marguerite; Doherty, Anne Marie; Alexander, Nicholas

    2012-01-01

    While on a global scale consumers are becoming more homogeneous, as a result of the increasingly globalized marketplace, researchers suggest that consumers within individual countries are becoming more culturally heterogeneous. Consequently, M. Cleveland and J. Laroche (2007. Acculturation to the global consumer culture: Scale development and research paradigm. Journal of Business Research, 60, 249–259) advocate segmenting consumers acrossmarkets on the basis of acculturation to the global co...

  15. Assessing Social Anxiety in African American Youth using the Social Phobia and Anxiety Inventory for Children

    OpenAIRE

    Pina, Armando A.; LITTLE, MICHELLE; Wynne, Henry; Beidel, Deborah C.

    2014-01-01

    Examined measurement invariance and cut-off scores of the Social Phobia and Anxiety Inventory for Children (SPAI-C) using data corresponding to a convenience sample of 501 African American and Caucasian youth (Mage = 11.62 years, 249 girls; 49% with social anxiety disorder) using exploratory structural equation modeling and a weighted least squares mean variance estimator. For the cut-off scores, Receiver Operator Characteristic analyses were used along with Youden’s index to evaluate the bal...

  16. 3-(2H-Tetrazol-5-ylpyridinium trifluoroacetate

    Directory of Open Access Journals (Sweden)

    Li Zhang

    2009-10-01

    Full Text Available In the cation of the title compound, C6H6N5+·CF3COO−, the pyridine and tetrazole rings are nearly coplanar, making a dihedral angle of 2.49 (19°. In the crystal, the cations and anions are connected by intermolecular N—H...O and N—H...(F,O hydrogen bonds, forming centrosymmetric [2 + 2] aggregates, which stack along the a axis.

  17. The impact of board internationalization on earnings management

    OpenAIRE

    Hooghiemstra, Reginald; Hermes, Cornelis; Oxelheim, L.; Randoy, Trond

    2015-01-01

    Prior literature shows that choices regarding board composition are associated with earnings management. We add to this literature by examining the effects of the presence of a foreign board member on earnings management. Using a sample of 3,249 firm-year observations representing 586 non-financial listed Nordic firms during 2001-2008, we find that the presence of a non-Nordic, foreign director is associated with significantly higher levels of earnings management. Moreover, we provide prelimi...

  18. Production of Bioactive Peptides from Soybean Meal by Solid State Fermentation with Lactic Acid Bacteria and Protease

    OpenAIRE

    Naifu Wang; Guowei Le; Yonghui Shi; Yuan Zeng

    2014-01-01

    In this study, soybean meal was first solid state fermented with different strains of Lactic Acid Bacteria (LAB). Among the strains used, Lactobacillus plantarum Lp6 was selected for further studies because of its highest Degree of Hydrolysis (DH) of protein (2.49±0.08%) in soybean meal after 72 h fermentation. Soybean meal fermented with L. plantarum Lp6 can also improve its DPPH radical scavenging and Angiotensin Converting Enzyme (ACE) inhibitory activities. The addition of protease into s...

  19. 75 FR 50784 - Proposed Collection; Comment Request

    Science.gov (United States)

    2010-08-17

    ... N-CSR; SEC File No. 270-512; OMB Control No. 3235-0570. Notice is hereby given that, pursuant to the... extension and approval. Form N-CSR (17 CFR 249.331 and 274.128) is a combined reporting form used by... 1934 (15 U.S.C. 78a et seq.) (``Exchange Act''). Form N-CSR is to be used for reports under Section...

  20. 78 FR 43250 - Proposed Collection; Comment Request

    Science.gov (United States)

    2013-07-19

    ... N-CSR. SEC File No. 270-512, OMB Control No. 3235-0570 Notice is hereby given that, pursuant to the... extension and approval. Form N-CSR (17 CFR 249.331 and 274.128) is a combined reporting form used by... Exchange Act of 1934 (15 U.S.C. 78a et seq.) (``Exchange Act''). Specifically, Form N-CSR is to be used...

  1. Retinopathy of prematurity: review of a four-year period.

    OpenAIRE

    Cats, B P; Tan, K E

    1985-01-01

    For a four-year period the development of retinopathy of prematurity (ROP) was determined among neonates considered at risk of acquiring this condition. Fifty-six out of 249 premature infants developed some degree of ROP. Comparison of these infants with a group of 56 controls, admitted to hospital in the same period and matched for sex, birth weight, and gestational age, showed significant differences for sepsis, blood transfusions, and the period of oxygen monitoring in relation to the peri...

  2. Humidity and Cage and Bedding Temperatures in Unoccupied Static Mouse Caging after Steam Sterilization

    OpenAIRE

    Ward, Gina M; Cole, Kelly; Faerber, Jennifer; Hankenson, F Claire

    2009-01-01

    Contemporary rodent caging and equipment often are sterilized by steam autoclaves prior to use in facilities. This work assessed the microenvironment of unoccupied static mouse cages after steam sterilization to determine when internal temperatures had cooled to levels appropriate for rodent housing. Polycarbonate static cages containing food and corncob bedding were stacked (10 rows × 7 columns) in duplicate (front and back; n = 140 cages) on a storage truck and autoclaved to 249 °F (121 °C)...

  3. The Effect of Video Game “Warm-up” on Performance of Laparoscopic Surgery Tasks

    OpenAIRE

    Rosser, James C.; Gentile, Douglas A.; Hanigan, Kevin; Danner, Omar K.

    2012-01-01

    Background: Performing laparoscopic procedures requires special training and has been documented as a significant source of surgical errors. “Warming up” before performing a task has been shown to enhance performance. This study investigates whether surgeons benefit from “warming up” using select video games immediately before performing laparoscopic partial tasks and clinical tasks. Methods: This study included 303 surgeons (249 men and 54 women). Participants were split into a control (n=18...

  4. Self-Regulation and Dimensions of Parenting Styles Predict Psychological Procrastination of Undergraduate Students

    OpenAIRE

    Habibeh Mortazanajad; Faride mostafafi; Shahram Vahedi

    2009-01-01

    "n Objective: "n "nPrevious research has linked self regulation and parenting styles separately to academic procrastination. This article investigates the impact of the dimensions of parenting styles, behavioral self regulation and short term self regulation on procrastination of students. "nMethod: A sample of 249 adolescents (174 females and 75 male) aged 19 - 21 years completed measures of Parent as Social Context Questionnaire- Adolescent Report, Self-regulation Questionnaire (SRQ), ...

  5. Prophylactic Efficacy of Amifostine, DRDE-07, and their Analogues against Percutaneously Administered Nitrogen Mustards and Sulphur Mustard

    OpenAIRE

    Manoj Sharma; Vijayaraghavan, R.; Uma Pathak; K. Ganesan

    2009-01-01

    Nitrogen mustards (HN-1, HN-2 and HN-3) and sulphur mustard are alkylating and blister-inducing chemical warfare agents. This study was aimed at investigating the prophylactic efficacy of amifostine, DRDE-07, and their analogues and some recommended antidotes against dermally-applied nitrogen mustards and sulphur mustard in preventing their systemic toxicity in mice. The antidotes were administered as single oral dose, 30 min prior to the mustard agent application. For DRDE-07, 0.2 LD50 (249 ...

  6. Optic Nerve Avulsion after Blunt Trauma

    Directory of Open Access Journals (Sweden)

    Hacı Halil Karabulut

    2014-05-01

    Full Text Available Optic nerve avulsion is an uncommon presentation of ocular trauma with a poor prognosis. It can be seen as complete or partial form due to the form of trauma. We assessed the complete optic nerve avulsion in a 16-year-old female patient complaining of loss of vision in her left eye after a traffic accident. (Turk J Ophthalmol 2014; 44: 249-51

  7. Influences on Human Resource Management Practices in Multinational Corporations

    OpenAIRE

    Phillip M Rosenzweig; Nitin Nohria

    1994-01-01

    A study of human resource management practices in 249 U.S. affiliates of foreign-based multinational corporations (MNCs) shows that in general affiliate HRM practices closely follow local practices, with differences among specific practices. The degree of similarity of local practices is significantly influenced by the method of founding, dependence on local inputs, the presence of expatriates, and the extent of communication with the parent. In addition, sharp differences are revealed among ...

  8. An analysis of 939 patients in an 18-month follow up

    OpenAIRE

    Herbstleb, Joachim

    2010-01-01

    The treatment of acute myocardial infarction has changed in recent years on account of reperfusion therapy and optimized medical secondary prevention. However, the question remains unclarified as to which factors of influence determine the prognosis for postmyocardial infarction patients undergoing contemporary therapy. In a prospective register we examined 939 revascularized postmyocardial infarction patients (men 75.1 %, women 24.9 %, median age 62.53 +/- 10.16 or 66.39 +/- 10.65 years)...

  9. Annual Scheduling of Atlantic Fleet Surface Combatants

    OpenAIRE

    Gerald G. Brown; Goodman, Clark E., Jr.; Wood, R. Kevin

    1990-01-01

    Operations Research, 38, pp. 249-259. Employment scheduling is the process whereby U. S. Navy ships, submarines, aircraft and other units are assigned to major operations, exercises, maintenance periods, inspections and other events; the employment schedule directly influencesfleet combat readiness. Currently, this process is largely manual requiring several full-time scheduling officers and additional personnel at various levels of management. We introduce an optimization model t...

  10. A comprehensive alanine-scanning mutagenesis study reveals roles for salt bridges in the structure and activity of Pseudomonas aeruginosa elastase.

    Science.gov (United States)

    Bian, Fei; Yue, Shousong; Peng, Zhenying; Zhang, Xiaowei; Chen, Gao; Yu, Jinhui; Xuan, Ning; Bi, Yuping

    2015-01-01

    The relationship between salt bridges and stability/enzymatic activity is unclear. We studied this relationship by systematic alanine-scanning mutation analysis using the typical M4 family metalloprotease Pseudomonas aeruginosa elastase (PAE, also known as pseudolysin) as a model. Structural analysis revealed seven salt bridges in the PAE structure. We constructed ten mutants for six salt bridges. Among these mutants, six (Asp189Ala, Arg179Ala, Asp201Ala, Arg205Ala, Arg245Ala and Glu249Ala) were active and four (Asp168Ala, Arg198Ala, Arg253Ala, and Arg279Ala) were inactive. Five mutants were purified, and their catalytic efficiencies (kcat/Km), half-lives (t1/2) and thermal unfolding curves were compared with those of PAE. Mutants Asp189Ala and Arg179Ala both showed decreased thermal stabilities and increased activities, suggesting that the salt bridge Asp189-Arg179 stabilizes the protein at the expense of catalytic efficiency. In contrast, mutants Asp201Ala and Arg205Ala both showed slightly increased thermal stability and slightly decreased activity, suggesting that the salt bridge Asp201-Arg205 destabilizes the protein. Mutant Glu249Ala is related to a C-terminal salt bridge network and showed both decreased thermal stability and decreased activity. Furthermore, Glu249Ala showed a thermal unfolding curve with three discernable states [the native state (N), the partially unfolded state (I) and the unfolded state (U)]. In comparison, there were only two discernable states (N and U) in the thermal unfolding curve of PAE. These results suggest that Glu249 is important for catalytic efficiency, stability and unfolding cooperativity. This study represents a systematic mutational analyses of salt bridges in the model metalloprotease PAE and provides important insights into the structure-function relationship of enzymes. PMID:25815820

  11. Risk Factors for Treatment Failure in Smokers: Relationship to Alcohol Use and to Lifetime History of an Alcohol Use Disorder

    OpenAIRE

    Leeman, Robert F.; McKee, Sherry A.; Toll, Benjamin A.; Krishnan-Sarin, Suchitra; Cooney, Judith L.; Makuch, Robert W.; O’Malley, Stephanie

    2008-01-01

    Little is known about the impact of alcohol involvement on smoking cessation relapse or possible mechanisms for these associations. We addressed these issues using data from a randomized clinical trial of 2 types of framed messages (gain vs. loss) in conjunction with open label sustained-release (SR) bupropion (Toll et al., 2007) (N = 249). Participants were categorized according to whether or not they were diagnosed with a lifetime alcohol use disorder (AUD; i.e., current or past alcohol abu...

  12. Predictors of job satisfaction and burnout among tuberculosis management nurses and physicians

    OpenAIRE

    Seo, Hae-Suk; Kim, Hyunjoong; Hwang, Se-Min; Hong, Soo Hyun; Lee, In-Young

    2016-01-01

    OBJECTIVES: This study examined job satisfaction, empowerment, job stress, and burnout among tuberculosis management nurses and physicians in public healthcare institutions. METHODS: This was a cross-sectional study analyzing survey data collected from 249 nurses and 57 physicians in 105 public health centers, three public tuberculosis hospitals, and one tertiary hospital. The survey questionnaire comprised general characteristics, work-related characteristics, and four index scales (job sati...

  13. A limited set of starch related genes explain several interrelated traits in potato

    OpenAIRE

    Werij, J.S.; Furrer-Verhorst, M.; Eck, van, Pascal; Visser, R. G. F.; Bachem, C.W.B.

    2012-01-01

    To understand the molecular basis of potato starch related traits and the underlying starch biosynthesis and degradation, a Quantitative Trait Locus (QTL) analysis in combination with a candidate gene approach was performed. The diploid mapping population C × E, consisting of 249 individuals, was assayed over two consecutive years, for chipping colour, cold induced sweetening, starch content, starch granule size, starch gelling temperature, starch enthalpy, amylose content and degree of starc...

  14. Prevalence of obesity and abdominal obesity in the Lausanne population.

    OpenAIRE

    Paccaud Fred; Mooser Vincent; Bochud Murielle; Marques-Vidal Pedro; Waeber Gérard; Vollenweider Peter

    2008-01-01

    Abstract Background Obesity can be defined using body mass index (BMI) or waist (abdominal obesity). Little information exists regarding its prevalence and determinants in Switzerland. Hence, we assessed the levels of obesity as defined by BMI or waist circumference in a Swiss population-based sample. Methods Cross-sectional, population-based non-stratified random sample of 3,249 women and 2,937 men aged 35–75 years living in Lausanne, Switzerland. Overall participation rate was 41%. Results ...

  15. Defining Quantum Control Flow

    OpenAIRE

    Ying, Mingsheng; Yu, Nengkun; Feng, Yuan

    2012-01-01

    A remarkable difference between quantum and classical programs is that the control flow of the former can be either classical or quantum. One of the key issues in the theory of quantum programming languages is defining and understanding quantum control flow. A functional language with quantum control flow was defined by Altenkirch and Grattage [\\textit{Proc. LICS'05}, pp. 249-258]. This paper extends their work, and we introduce a general quantum control structure by defining three new quantu...

  16. Identification of a DNA transformation gene required for com101A+ expression and supertransformer phenotype in Haemophilus influenzae.

    OpenAIRE

    Zulty, J J; Barcak, G J

    1995-01-01

    DNA sequencing, RNA mapping, and protein expression experiments revealed the presence of a gene, tfoX+, encoding a 24.9-kDa polypeptide, that is transcribed divergently from a common promoter region with the Haemophilus influenzae rec-1+ gene. H. influenzae strains mutant for tfoX failed to bind transforming DNA and were transformation deficient. Primer extension experiments utilizing in vivo total RNA from precompetent and competent H. influenzae cells demonstrated that transcription of tfoX...

  17. Detection of Neisseria gonorrhoeae antigen by a solid-phase enzyme immunoassay.

    OpenAIRE

    Aardoom, H A; hoop, D', B.B.; Iserief, C O; Michel, M F; Stolz, E

    1982-01-01

    The Gonozyme test (Abbott Laboratories) is a new enzyme immunoassay for detecting Neisseria gonorrhoeae antigens in specimens from the urethra in men and the endocervix in women. To evaluate the usefulness of the assay 249 patients were investigated. The results obtained with the immunoassay were compared with those of culture and microscopy of Gram-stained smears. The sensitivity and specificity of the test were high in men with urethritis and acceptable in different groups of women. As the ...

  18. Nucleon structure from 2+1-flavor dynamical DWF ensembles

    CERN Document Server

    Abramczyk, Michael; Lytle, Andrew; Ohta, Shigemi

    2016-01-01

    Nucleon isovector vector- and axialvector-current form factors, the renormalized isovector transversity and scalar charge, and the bare quark momentum and helicity moments of isovector structure functions are reported with improved statistics from two recent RBC+UKQCD 2+1-flavor dynamical domain-wall fermions ensembles: Iwasaki\\(\\times\\)DSDR gauge \\(32^3\\times64\\) at inverse lattice spacing of 1.38 GeV and pion mass of 249 and 172 MeV.

  19. Narcolepsy and pregnancy

    DEFF Research Database (Denmark)

    Maurovich-Horvat, Eszter; Kemlink, David; Högl, Birgit;

    2013-01-01

    In a retrospective cohort study undertaken in 12 European countries, 249 female narcoleptic patients with cataplexy (n = 216) and without cataplexy (n = 33) completed a self-administrated questionnaire regarding pregnancy and childbirth. The cohort was divided further into patients whose symptoms...... of narcolepsy started before or during pregnancy (308 pregnancies) and those in whom the first symptoms of narcolepsy appeared after delivery (106 pregnancies). Patients with narcolepsy during pregnancy were older during their first pregnancy (P ...

  20. Comparaci??n del valor de pertinencia de las normas contables en EE.UU. versus las normas internacionales de informaci??n financiera: el caso de las American Depositary Receipts

    OpenAIRE

    Lozada Rivera, Aida Raquel

    2015-01-01

    249 p. La presente tesis doctoral analiza la utilidad para los inversionistas de la divulgaci??n de la cifra de resultado cuando las empresas comunican su informaci??n financiera utilizando las Normas Internacionales de Informaci??n Financiera (NIIF) y las normas contables estadounidenses, conocidas como Principios de Contabilidad Generalmente Aceptados o ???U.S. Generally Accepted Accounting Principles??? (U.S. GAAP). Para ello se utiliz?? como muestra de empresas las conocidas como ?...

  1. Drug: D05014 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D05014 Drug Mettreleptin (genetical recombination) (JAN); Metreleptin (USAN/INN); Metreleptin... [metabolic homeostasis regulator] Therapeutic category: 2499 leptin [CPD:C18188] analogue N-methionylleptin (human) leptin...ans 24 Hormones 249 Miscellaneous 2499 Others D05014 Mettreleptin (genetical recombination) (JAN); Metreleptin...s Class I cytokine receptors (hematopoietin family receptors) leptin receptor [HSA:3953] [KO:K05062] Metreleptin D05014 Metreleptin (USAN/INN) CAS: 186018-45-1 PubChem: 47206741 ...

  2. Variations in cone beam CT numbers as a function of patient size: in vivo demonstration in bladder cancer patients

    International Nuclear Information System (INIS)

    Full text: We determined Hounsfield numbers, using cone beam CT (CBCT), in the bladder of 27 muscle invasive bladder cancer patients treated with online adaptive radiotherapy using a Varian linear accelerator. The CBCT number of urine was found to increase by 130 from the thinnest to the largest patient (249 mm to 346 mm average diameter) demonstrating the effect of patient size on Hounsfield number in CBCT in vivo.

  3. An empirical investigation on factors influencing on brand loyalty

    OpenAIRE

    Naser Azad; Masoud Hassanabadi

    2013-01-01

    Building a competitive brand is a key success specially in banking industry. This paper presents a study to investigate important factors influencing brand loyalty among special customers in one of biggest Iranian banks in Iran. The study designs a questionnaire and distributes it among 249 regular customers who are special customers in various banks in city of Tehran, Iran. The study uses structural equation modeling to find important factors and they are ranked using TOPSIS method. In our s...

  4. EVALUATION OF USE AND EFFECT OF NATUROLOGY THERAPEUTIC TECHNIQUES FOR THE TREATMENT OF PAIN

    OpenAIRE

    de Oliveira, Marina Augusta; Dias, Wagner Jose; Freitas, Bruna Rei

    2015-01-01

    This paper aimed to survey academic articles that evaluate techniques used by Naturology for pain treatment, and discuss data that would demonstrate or not the efficiency of these techniques. From research in the MEDLINE, SCIELO, LILACS, BIREME & DEDALUS databases, this study analyzed a total of 249 articles related to the following techniques: acupuncture, aromatherapy, auriculotherapy, phytotherapy, massage, complementary and alternative medicine, meditation, qigong, reiki, shiatsu, tai chi...

  5. Identifying Concerns of Parents of Young Children

    OpenAIRE

    Mackenzie, Sandra; Evers, Susan

    1986-01-01

    A survey was conducted to ascertain parenting concerns and willingness to participate in parenting groups as a means of addressing concerns. Questionnaires were sent to 121 families with a child aged three years or under. Mothers and fathers were asked to complete separate questionnaires. Analysis of the 85 sets of questionnaires returned indicates that more mothers (51.8%) than fathers (24.9%) had at least five parental concerns. The top five concerns of mothers were “discipline”, “childhood...

  6. The members of the Agency

    International Nuclear Information System (INIS)

    The document lists the 127 Member States of the Agency as of 1 January 1998. The new Members since the last issue of of the list (INFCIRC/2/49) are Malta and the Republic of Moldova. In an attachment are given the dates on which the present 127 states become Members, the state (Burkina Faso) whose application for membership of the Agency has been approved by the General Conference but which has not deposited an instrument of acceptance of the Statute

  7. Phenolic Content and Antioxidant Activity of Hibiscus cannabinus L. Seed Extracts after Sequential Solvent Extraction

    OpenAIRE

    Shahid Iqbal; Maznah Ismail; Noordin Mohd Yusri; Kim Wei Chan

    2012-01-01

    A sequential solvent extraction scheme was employed for the extraction of antioxidant compounds from kenaf (Hibiscus cannabinus L.) seeds. Yield of extracts varied widely among the solvents and was the highest for hexane extract (16.6% based on dry weight basis), while water extract exhibited the highest total phenolic content (18.78 mg GAE/g extract), total flavonoid content (2.49 mg RE/g extract), and antioxidant activities (p < 0.05). DPPH and hydroxyl radical scavenging, β...

  8. Multiresidue analytical procedures for pesticides residues in vegetable products; Metodi mutiresiduo per l`analisi di residui di antiparassitari in prodotti vegetali

    Energy Technology Data Exchange (ETDEWEB)

    Gruppo di lavoro per i residui di antiparassitari della Commissione permanente di coordinamento interregionale per i problemi relativi al controllo ufficiale dei prodotti alimentari

    1997-09-01

    Multiresidue methods for pesticide residues in vegetable products, most frequently used by laboratories of the Italian national health service, by the regional and provincial agencies for environmental protection and by the National health institute. The analytical behaviour is presented for 249 pesticides through the different steps of extraction and cleanup, along with data for the gas chromatography (GC), gas chromatography coupled to mass spectrometry (GC/MS) and high performance liquid chromatography coupled to spectrophotometric detector (HPL/UV).

  9. Effects of a Brief Meditation Training on Negative Affect, Trait Anxiety and Concentrated Attention

    OpenAIRE

    Carolina Baptista Menezes; Lisiane Bizarro

    2015-01-01

    AbstractMeditation has been associated with positive psychological outcomes, but few studies have investigated brief interventions. This randomized controlled pilot study assessed the effects of five days of focused meditation on positive and negative affect, state and trait anxiety, as well as concentrated attention in a nonclinical sample distributed in two groups (experimental = 14, 51.8% female, Mage= 23.9; control = 19, 62% female, Mage= 24.9). The instruments used were the Positive Affe...

  10. Antibiotic-coated medical devices: with an emphasis on inflatable penile prosthesis

    Institute of Scientific and Technical Information of China (English)

    R.Abouassaly; D.K.Montague; K.W.Angermeier

    2004-01-01

    One of the most serious complications associated with the use of the inflatable penile prosthesis is infection.This can lead to significant morbidity for the patient, as well as significant health care costs. A number of methods have been used in attempts at minimizing the infection risk, including applying an antibiotic coating to the medical devise. This review aims to evaluate the effectiveness of these products in preventing clinically significant infections.(Asian J Androl 2004 Sep; 6: 249-257)

  11. Preliminary organizational culture scale focused on artifacts

    OpenAIRE

    Bonavia, Tomas

    2006-01-01

    In this preliminary study, an organizational culture scale was developed to assess cultural artifacts according to Schein´s typology (1985). It includes a set of cultural artifacts to measure the extent to which an organization is more or less traditional. A total of 249 managers from a range of different companies responded to the items. Preliminary analysis yielded a one-dimensional scale with 14 items with high internal consistency and homogeneity.

  12. Stimulant ADHD medication and risk for substance abuse

    OpenAIRE

    Chang, Z.(Texas A&M University, College Station, TX, 77843, USA); Lichtenstein, P.; Halldner, L; D'Onofrio, B; Serlachius, E.; Fazel, S.; Långström, N.; Larsson, H

    2013-01-01

    Background: There are persistent concerns of long-term effects of stimulant ADHD medication on the development of substance abuse. Methods: Using Swedish national registers, we studied all individuals born between 1960 and 1998 and diagnosed with ADHD (26,249 men and 12,504 women). We investigated the association between stimulant ADHD medication in 2006 and substance abuse during 2009. Substance abuse was indexed by substance-related death, crime, or hospital visits. Results: ADHD medication...

  13. Drug: D04539 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D04539 Drug Insulin detemir (genetical recombination) (JAN); Insulin detemir (USAN/... 24 Hormones 249 Miscellaneous 2492 Pancreatic hormones D04539 Insulin detemir (genetical recombination) (JA...AE Insulins and analogues for injection, long-acting A10AE05 Insulin detemir D04539 Insulin detemir (genetica...ators Insulins Insulin detemir D04539 Insulin detemir (genetical recombination) (...temir [ATC:A10AE05] D04539 Insulin detemir (genetical recombination) (JAN); Insul

  14. Drug: D06404 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D06404 Drug Liraglutide (genetical recombination) (JAN); Liraglutide (USAN/INN); Vi...249 Miscellaneous 2499 Others D06404 Liraglutide (genetical recombination) (JAN); Liraglutide (USAN/INN) Ana...od glucose lowering drugs, excl. insulins A10BX07 Liraglutide D06404 Liraglutide (genetical recombination) (...ts Liraglutide D06404 Liraglutide (genetical recombination) (JAN); Liraglutide (U...ily Glucagon glucagon-like peptide 1 receptor [HSA:2740] [KO:K04581] Liraglutide [ATC:A10BX07] D06404 Liraglutide (genetica

  15. Exploring the role of information and communication technology on employees' work and family domains / Johannes Willem de Wet

    OpenAIRE

    De Wet, Johannes Willem

    2015-01-01

    Technology has become part of society’s everyday functions, changing rapidly and providing widespread mobility. In South Africa alone, the amount of internet users grew from 8,5 million to 24,9 million in only three years (2011-2014). Currently 90% of these users access this facility from their mobile devices. This statistic illustrates the trend that South Africans are moving towards a continually connected lifestyle, a situation in which information and communication technolo...

  16. p16 as a diagnostic marker of cervical neoplasia: a tissue microarray study of 796 archival specimens

    OpenAIRE

    Hamilton-Dutoit Stephen; Lidang Marianne; Lesnikova Iana; Koch Jørn

    2009-01-01

    Abstract Background To evaluate the usefulness of this biomarker in the diagnosis of cases of cervical neoplasia we studied the immunohistochemical expression of p16INK4a in a large series of archival cervical biopsies arranged into tissue microarray format. Methods TMAs were constructed with tissue cores from archival formalin fixed, paraffin-embedded donor tissues from 796 patients, and included cases of cervical intraepithelial neoplasia (CIN)1 (n = 249), CIN2 (n = 233), CIN3 (n = 181), an...

  17. 17 CFR 270.30a-2 - Certification of Form N-CSR and Form N-Q.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Certification of Form N-CSR... Form N-CSR and Form N-Q. (a) Each report filed on Form N-CSR (§§ 249.331 and 274.128 of this chapter... must include certifications in the form specified in Item 12(a)(2) of Form N-CSR or Item 3 of Form...

  18. Identification of the contamination source of plutonium in environmental samples with isotopic ratios determined by inductively coupled plasma mass spectrometry and alpha-spectrometry

    International Nuclear Information System (INIS)

    Concentrations of 239+249Pu in environmental samples were determined by ICP-MS and α spectrometry, showing consistent results, which suggests an applicability of ICP-MS to 239Pu and 240Pu measurement. The activity ratios of 238Pu/239+240Pu and 240Pu/239Pu were significantly different in samples from the general environment and near Sellafield reprocessing plants, indicating the usefulness of these ratios for identification of the Pu contamination source. (author)

  19. 携帯型装置を用いて測定した日常生活下での血圧日内変動

    OpenAIRE

    上園, 慶子; 川崎, 晃一; 佐々木, 悠; 宇都宮, 弘子; 上野, 道雄

    1993-01-01

    To know the characteristics of 24-hour variations of blood pressure(BP) and pulse rate (PR), ambulatory BP was monitored automatically every 30 minutes for 24-26 hours with non-invasive device, ABPM-630 (Nippon Colin Co.) in healthy volunteers (18-years of age). Four hundred and forty eight subjects (249 men and 199 women) joined in this study. Oscillometric method was superior in the numbers of detected measurements, whereas Korotkoff method had more failed measurements. After attachment of...

  20. Retroviral expression of the hepatitis B virus x gene promotes liver cell susceptibility to carcinogen-induced site specific mutagenesis.

    Science.gov (United States)

    Sohn, S; Jaitovitch-Groisman, I; Benlimame, N; Galipeau, J; Batist, G; Alaoui-Jamali, M A

    2000-06-30

    Mutational inactivation of the tumor suppressor gene p53 is common in hepatocellular carcinomas (HCC). AGG to AGT transversion in codon 249 of exon 7 of the p53 gene occurs in over 50% of HCC from endemic regions, where both chronic infection with the hepatitis B virus (HBV) and exposure to carcinogens such as aflatoxin B1 (AFB1) prevail. In this study, we report the effect of the HBV x protein (HBx) on carcinogen-induced cytotoxicity and AGG to AGT mutation in codon 249 of the p53 gene in the human liver cell line CCL13. Expression of HBx, as revealed by its transactivation function, results in enhanced cell susceptibility to cytotoxicity induced by the AFB1 active metabolite, AFB1-8,9-epoxide, and benzo(a)pyrene diol-epoxide. Under similar conditions, expression of HBx promotes apoptosis in a subset of cell population. Exposure to AFB1-8, 9-epoxide alone induces a low frequency of AGG to AGT mutation in codon 249 of the p53 gene, as determined by an allele-specific polymerase chain reaction (AS-PCR) assay. However, expression of HBx enhances the frequency of AFB1-epoxide-induced AGG to AGT mutation compared to control cells. In summary, this study demonstrates that expression of HBx enhances liver cell susceptibility to carcinogen-induced mutagenesis, possibly through alteration of the balance between DNA repair and apoptosis, two cellular defense mechanisms against genotoxic stress. PMID:10856831

  1. Effect of vanadium and titanium modification on the microstructure and mechanical properties of a microalloyed HSLA steel

    Energy Technology Data Exchange (ETDEWEB)

    Show, B.K., E-mail: bijay_show@rediffmail.com [Defence Metallurgical Research Laboratory, Kanchanbagh P.O., Hyderabad 500058, Andhra Pradesh (India); Veerababu, R., E-mail: veeru_met@yahoo.com [Defence Metallurgical Research Laboratory, Kanchanbagh P.O., Hyderabad 500058, Andhra Pradesh (India); Balamuralikrishnan, R., E-mail: bmk_pgh@yahoo.com [Defence Metallurgical Research Laboratory, Kanchanbagh P.O., Hyderabad 500058, Andhra Pradesh (India); Malakondaiah, G., E-mail: director@dmrl.drdo.in [Defence Metallurgical Research Laboratory, Kanchanbagh P.O., Hyderabad 500058, Andhra Pradesh (India)

    2010-03-15

    DMR-249A is a low carbon microalloyed high-strength low-alloy (HSLA) steel. While DMR-249A plates of thickness less than 18 mm meet the specified room temperature yield strength (390 MPa) and Charpy impact toughness (78J at -60 deg. C) in the as-rolled condition, thicker plates require water quenching and tempering. Elimination of the quenching and tempering treatment can result in significant cost and energy savings besides offering increased productivity. Therefore, in the present work, modifications to the base DMR-249A steel composition have been investigated with the objective of producing thicker gage plates (24 mm) capable of meeting the specified properties in the normalized condition. Plates from three modified compositions i.e., containing 0.015 wt.% titanium and 0.06, 0.09 and 0.12 wt.% vanadium respectively and one composition with 0.10 wt.% vanadium, and without any titanium were investigated over a range of normalizing temperatures (875-1000 deg. C). In all cases, only the steel without titanium met the specified properties in the normalized condition. Microstructural investigations using scanning and transmission electron microscopy, as well as support evidence from calculations performed using ThermoCalc software, suggest that this is due to the presence of nanoscale vanadium rich carbonitride particles distributed throughout the matrix. These particles were absent in the titanium-containing steel at a similar vanadium level.

  2. Investigation on Internet addiction disorder in adolescents in Anhui, People’s Republic of China

    Science.gov (United States)

    Chen, Yan; Kang, Yaowen; Gong, Weizhi; He, Lianping; Jin, Yuelong; Zhu, Xiaoyue; Yao, Yingshui

    2016-01-01

    Background and aim The purpose of this study was to describe the characteristics and prevalence of Internet addiction (IA) in adolescents so as to provide a scientific basis for the communities, schools, and families. Methods We conducted a survey by randomized cluster sampling on 5,249 students, grades ranging from 7 to 12, in Anhui province, People’s Republic of China. The questionnaire consisted of general information and IA test. Chi-square test was used to compare the status of IA disorder (IAD). Results In our results, the overall detection rate of IAD and non-IAD in students was 8.7% (459/5,249) and 76.2% (4,000/5,249), respectively. The detection rate of IAD in males (12.3%) was higher than females (4.9%). The detection rate of IAD was statistically different between students from rural (8.2%) and urban (9.3%) areas, among students from different grades, between students from only-child families (9.5%) and non-only-child families (8.1%), and among students from different family types. Conclusion Prevalence of IA is high among Chinese adolescents. IAD has more effect on male students, single-child families, single-parent families, and higher grade students. We should take more care of male students, only-child students, and students living with their fathers, and related education should be strengthen for susceptible subjects of IDA.

  3. Prevalence of selected sexually and blood-borne infections in Injecting drug abuser inmates of bandar abbas and roodan correction facilities, Iran, 2002

    Directory of Open Access Journals (Sweden)

    Parivash Davoodian

    2009-10-01

    Full Text Available Human Immunodeficiency Virus (HIV and other blood borne viral infections like hepatitis B virus (HBV and hepatitis C virus (HCV are major health issues especially in young and growing population of developing countries. All around the globe correctional facilities are known as potential source of spreading such disease. During summer 2002, HIV, HCV antibodies, hepatitis B surface (HBs antigen and rapid plasma reagin (RPR test were checked in venous blood samples of 252 injecting drug abuser prisoners from correctional facilities in southern Iran. Overall HIV, HCV and HBV infection rate was 15.1% (38/249, 64.8% (163/249, and 4.7% (12/249, respectively. HCV infection rate of HIV positive cases was 94% (35/38. All RPR results were negative. Duration of previous drug abuse and imprisonment were correlated with HIV and HCV infection (p value = 0.0003 and 0.015 & p value =0.02 and 0.02. Considering the higher prevalence of HIV and HCV infection in correctional facilities compared to general population of Iran, warrants immediate multidisciplinary approaches targeted at controlling further spread of these infections primarily among prisoners and secondarily preventing them to act as carrier to general population.

  4. 毛细管电泳和聚丙烯酰胺电泳法检测肺癌组织p53基因突变效果分析%Detection of p53 gene point mutation in lung cancer tissue by capillary electrophoresis and polyacrylamide gel electrophoresis

    Institute of Scientific and Technical Information of China (English)

    辛晓婷; 王荣; 高岚; 贾正平; 刘圆圆; 刘勇

    2008-01-01

    目的 筛选检测肺癌组织p53基因突变的优良方法,为临床早期诊断肺癌提供依据.方法 分别运用毛细管电泳(CE)与聚丙烯酰胺电泳(PAGE)一限制性片段长度多态性(RFLP)两种方法对38例肺癌及癌旁正常组织p53基因第249位密码子点突变进行检测.结果 RFLP-CE可检测到p53基因第249位密码子的野生型26 bp片段,用时<20 min;RFLP-CE和RFLP-PAGE均能检测到基因突变,对29例非小细胞肺癌组织p53基因第249位密码子检测的突变率分别为31.03%(9/29)、20.69%(6/29),P<0.05.结论 RFLP-CE可为大规模进行肺癌的早期诊断提供简便可靠的方法.

  5. Short communication. Further evidence of lineage 2 West Nile Virus in Culex pipiens of North-Eastern Italy

    Directory of Open Access Journals (Sweden)

    Gioia Capelli

    2013-09-01

    Full Text Available West Nile Virus lineage 1 (WNV lin1 emerged in North-Eastern Italy in 2008 and, since then, it has been detected in animals, humans and mosquitoes. Three years later, in the same area, a lineage 2 (lin2 strain of WNV was found in birds and vectors. On August the 21st, during the 2012 WNV entomological surveillance plan, a WNV lin2 strain was detected by RT-PCR in a pool of Culex pipiens mosquitoes captured in Veneto region. According to the alignment of the partial sequences of the NS5 and NS3 genes, no differences between this Italian lineage 2 strain and the Nea Santa-Greece-2010 WNV isolate (Gr-10 were observed. Similarly to the Gr-10 strain, the putative NS3 aminoacid sequences of the Italian strain showed proline in position 249 instead of histidine (H249P. Although proline in position 249 has been suggested to increase the virulence of WNV strains, neither human nor veterinary cases associated to this strain have been reported in the region. A prompt mosquito disinfestation was organized to avoid the spread of this potential threatening virus. The simultaneous circulation of both WNV lineage 1 and 2 confirms North-Eastern Italy as a high risk area for WNV emergence and highlights the need for a continuous surveillance.

  6. Effect of vanadium and titanium modification on the microstructure and mechanical properties of a microalloyed HSLA steel

    International Nuclear Information System (INIS)

    DMR-249A is a low carbon microalloyed high-strength low-alloy (HSLA) steel. While DMR-249A plates of thickness less than 18 mm meet the specified room temperature yield strength (390 MPa) and Charpy impact toughness (78J at -60 deg. C) in the as-rolled condition, thicker plates require water quenching and tempering. Elimination of the quenching and tempering treatment can result in significant cost and energy savings besides offering increased productivity. Therefore, in the present work, modifications to the base DMR-249A steel composition have been investigated with the objective of producing thicker gage plates (24 mm) capable of meeting the specified properties in the normalized condition. Plates from three modified compositions i.e., containing 0.015 wt.% titanium and 0.06, 0.09 and 0.12 wt.% vanadium respectively and one composition with 0.10 wt.% vanadium, and without any titanium were investigated over a range of normalizing temperatures (875-1000 deg. C). In all cases, only the steel without titanium met the specified properties in the normalized condition. Microstructural investigations using scanning and transmission electron microscopy, as well as support evidence from calculations performed using ThermoCalc software, suggest that this is due to the presence of nanoscale vanadium rich carbonitride particles distributed throughout the matrix. These particles were absent in the titanium-containing steel at a similar vanadium level.

  7. Investigation on Internet addiction disorder in adolescents in Anhui, People’s Republic of China

    Science.gov (United States)

    Chen, Yan; Kang, Yaowen; Gong, Weizhi; He, Lianping; Jin, Yuelong; Zhu, Xiaoyue; Yao, Yingshui

    2016-01-01

    Background and aim The purpose of this study was to describe the characteristics and prevalence of Internet addiction (IA) in adolescents so as to provide a scientific basis for the communities, schools, and families. Methods We conducted a survey by randomized cluster sampling on 5,249 students, grades ranging from 7 to 12, in Anhui province, People’s Republic of China. The questionnaire consisted of general information and IA test. Chi-square test was used to compare the status of IA disorder (IAD). Results In our results, the overall detection rate of IAD and non-IAD in students was 8.7% (459/5,249) and 76.2% (4,000/5,249), respectively. The detection rate of IAD in males (12.3%) was higher than females (4.9%). The detection rate of IAD was statistically different between students from rural (8.2%) and urban (9.3%) areas, among students from different grades, between students from only-child families (9.5%) and non-only-child families (8.1%), and among students from different family types. Conclusion Prevalence of IA is high among Chinese adolescents. IAD has more effect on male students, single-child families, single-parent families, and higher grade students. We should take more care of male students, only-child students, and students living with their fathers, and related education should be strengthen for susceptible subjects of IDA. PMID:27621633

  8. Synthesis of a new element with Z=117

    Science.gov (United States)

    Hamilton, Joseph

    2010-10-01

    The synthesis of new elements with neutron number (N) approaching 184 provide important tests of nuclear structure models used to predict closed spherical shells in the heaviest elements. Earlier, elements with Z=113-116, and 118 were synthesized in reactions of ^48Ca with actinide targets at JINR. The synthesis of previously unknown Z=117 can provide additional crucial tests of the shell structure near the predicted Island of Stability with N=184. Here we report the synthesis of ^293,294117 (N=176,177) in the ^48Ca + ^249Bk 4n and 3n reactions. The ^249Bk was produced at ORNL in the High Flux Isotope Reactor and chemically separated at the Radiochemical Engineering Development Center at ORNL. Six arc-shaped targets of 0.31 mg/cm^2 of ^249Bk were made at the Research Institute of Atomic Reactors (Dimitrovgrad). The experiments were performed employing the Dubna Gas-Filled Recoil Separator and the heavy-ion cyclotron U-400 at JINR, Russia. Separated evaporation residues were registered by a time-of-fight system and implanted in a 4 cm x 12 cm Si-detector array with 12 vertical position-sensitive strips surrounded by eight 4 cm x 4 cm side detectors. Irradiation at 252 MeV for 70 days starting July 27, with a total beam dose of 2.4 x 10^19 yielded five position-correlated (heavy elements and their place in the Periodic Table.

  9. Especially for High School Teachers

    Science.gov (United States)

    Howell, J. Emory

    2000-01-01

    Ideas and Resources in This Issue This issue contains a broad spectrum of topics of potential interest to high school teachers, including chemical safety, history, demonstrations, laboratory activities, electrochemistry, small group learning, and instructional software. In his report on articles published recently in The Science Teacher, Steve Long includes annotated references from that journal, and also from JCE, that provide timely and practical information (pp 21-22). The chemical significance of several anniversaries that will occur in the year 2000 are discussed in an article by Paul Schatz (pp 11-14). Scientists and inventors mentioned include Dumas, Wöhler, Goodyear, Joliot-Curie, Krebs, Pauli, Kjeldahl, and Haworth. Several discoveries are also discussed, including development of the voltaic pile, the use of chlorine to purify water, and the discovery of element 97, berkelium. This is the fourth consecutive year that Schatz has written an anniversaries article (1-3). Although most readers probably do not plan to be teaching in the years 2097-3000, these articles can make a nice addition to your file of readily available historical information for use now in meeting NSES Content Standard G (4). In contrast to the short historical summaries, an in-depth account of the work of Herman Boerhaave is provided by Trinity School (NY) teacher Damon Diemente. You cannot recall having heard of Boerhaave? Diemente explains in detail how Boerhaave's scientific observations, imperfect though they were, contributed significantly to the understanding of temperature and heat by scientists who followed him. Chemical demonstrations attract the interest of most of us, and Kathy Thorsen discusses several that appeared in Chem 13 News during the past year (pp 18-20). Included are demonstrations relating to LeChâtelier's principle, electronegativity, and the synthesis and reactions of carbon monoxide. Ideas for investigating the hydrophobic nature of Magic Sand are given in JCE

  10. 2010 Neutron Review: ORNL Neutron Sciences Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    Bardoel, Agatha A [ORNL; Counce, Deborah M [ORNL; Ekkebus, Allen E [ORNL; Horak, Charlie M [ORNL; Nagler, Stephen E [ORNL; Kszos, Lynn A [ORNL

    2011-06-01

    During 2010, the Neutron Sciences Directorate focused on producing world-class science, while supporting the needs of the scientific community. As the instrument, sample environment, and data analysis tools at High Flux Isotope Reactor (HFIR ) and Spallation Neutron Source (SNS) have grown over the last year, so has promising neutron scattering research. This was an exciting year in science, technology, and operations. Some topics discussed are: (1) HFIR and SNS Experiments Take Gordon Battelle Awards for Scientific Discovery - Battelle Memorial Institute presented the inaugural Gordon Battelle Prizes for scientific discovery and technology impact in 2010. Battelle awards the prizes to recognize the most significant advancements at national laboratories that it manages or co-manages. (2) Discovery of Element 117 - As part of an international team of scientists from Russia and the United States, HFIR staff played a pivotal role in the discovery by generating the berkelium used to produce the new element. A total of six atoms of ''ununseptium'' were detected in a two-year campaign employing HFIR and the Radiochemical Engineering Development Center at Oak Ridge National Laboratory (ORNL) and the heavy-ion accelerator capabilities at the Joint Institute for Nuclear Research in Dubna, Russia. The discovery of the new element expands the understanding of the properties of nuclei at extreme numbers of protons and neutrons. The production of a new element and observation of 11 new heaviest isotopes demonstrate the increased stability of super-heavy elements with increasing neutron numbers and provide the strongest evidence to date for the existence of an island of enhanced stability for super-heavy elements. (3) Studies of Iron-Based High-Temperature Superconductors - ORNL applied its distinctive capabilities in neutron scattering, chemistry, physics, and computation to detailed studies of the magnetic excitations of iron-based superconductors (iron

  11. Relation of Smoking with Fibrinogenic Bβ-chain Gene Polymorphisms and its Clinical Index in Han Male Retirees of Tangsham%唐山市汉族退休男性吸烟与纤维蛋白原临床指标及其Bβ链基因多态性的相关性

    Institute of Scientific and Technical Information of China (English)

    王淑娟; 许亚茹; 元小冬; 李静; 杨娜

    2012-01-01

    目的 研究唐山市汉族退休男性吸烟与纤维蛋白原(Fg)Bβ链位点基因多态性和血浆Fg水平及其聚合功能的关系.方法 选取唐山市开滦集团汉族退休男性职工890人作为调查对象,均抽取清晨空腹静脉血测定白细胞介素(IL)、血浆Fg水平和纤维蛋白单体聚合反应速率(FMPV)、最大光密度Amax)、FMPV/Amax 等反映Fg聚合功能的指标,应用聚合酶链反应-限制性内切酶片段长度多态性技术检测FgBβ链-854G/A、-455G/A、-249C/T、-148CT、448G/A和Bcl-1G/A6个位点的基因多态性.结果 男性吸烟和不吸烟人群均表现为FgBβ-854位点变异基因型者的血浆Fg系列指标高于野生基因型人群,差异有统计学意义(P<0.05).FgBβ-249 位点变异基因型人群中男性吸烟者的血浆Fg水平、FMPV 及FMPV/Amax均明显高于不吸烟人群,差异有统计学意义(P<.05).结论 FgBβ-854基因多态性位点是影响血浆Fg水平和分子活性功能表达的重要基因位点.吸烟可能与Fg Bβ-249基因型相互作用而使血浆Fg水平升高,并可能影响Bβ-854基因型表达而使血浆Fg分子活性功能增强.%Objective To study the conelation of smoking in Han male retiree of Tangshan with Bβ-854G/A, -455G/A, -249C/T, -148C/T, 448G/A, Bcl-IG/A gene polymorphisms of fibrinogen(Fg), plasma Fg concentration and molecular reactivity. Methods 890 Han male retirees from Tangshan Kailuan Corporation were enrolled. All subjects were phlebotomized in the early morning to measure serum interleukin(IL), Fg concentration, fibrin monomer polymerized velocity(FMPV), absorbance maximum (Amax) and FMPV/Amax, furthermore, to detect six loci of the gene polymorphisms. The characters of the gene polymorphisms and functional expression of Fg based on smoking status were analyzed. Results In both the groups, the serial indexes of Fg with mutated genotype of Bβ-854 were all higher than those with wild genotypes ( P<0.05 ); Fg concentration, FMPV

  12. Mechanistic and computational studies of the reductive half-reaction of tyrosine to phenylalanine active site variants of D-arginine dehydrogenase.

    Science.gov (United States)

    Gannavaram, Swathi; Sirin, Sarah; Sherman, Woody; Gadda, Giovanni

    2014-10-21

    The flavin-mediated enzymatic oxidation of a CN bond in amino acids can occur through hydride transfer, carbanion, or polar nucleophilic mechanisms. Previous results with D-arginine dehydrogenase from Pseudomonas aeruginosa (PaDADH) using multiple deuterium kinetic isotope effects (KIEs) and computational studies established preferred binding of the substrate protonated on the α-amino group, with cleavages of the NH and CH bonds occurring in asynchronous fashion, consistent with the three possible mechanisms. The hydroxyl groups of Y53 and Y249 are ≤4 Å from the imino and carboxylate groups of the reaction product iminoarginine, suggesting participation in binding and catalysis. In this study, we have investigated the reductive half-reactions of the Y53F and Y249F variants of PaDADH using substrate and solvent deuterium KIEs, solvent viscosity and pH effects, and quantum mechanical/molecular mechanical computational approaches to gain insights into the catalytic roles of the tyrosines and evaluate whether their mutations affect the transition state for substrate oxidation. Both Y53F and Y249F enzymes oxidized D-arginine with steady-state kinetic parameters similar to those of the wild-type enzyme. Rate constants for flavin reduction (k(red)) with D-leucine, a slow substrate amenable to rapid kinetics, were 3-fold smaller than the wild-type value with similar pKa values for an unprotonated group of ∼10.0. Similar pKa values were observed for (app)Kd in the variant and wild-type enzymes. However, cleavage of the substrate NH and CH bonds in the enzyme variants occurred in synchronous fashion, as suggested by multiple deuterium KIEs on k(red). These data can be reconciled with a hydride transfer mechanism, but not with carbanion and polar nucleophilic mechanisms. PMID:25243743

  13. Comparison of the Efficacy of Everolimus-Eluting Stents Versus Drug-Eluting Balloons in Patients With In-Stent Restenosis (from the RIBS IV and V Randomized Clinical Trials).

    Science.gov (United States)

    Alfonso, Fernando; Pérez-Vizcayno, María José; García Del Blanco, Bruno; García-Touchard, Arturo; Masotti, Mónica; López-Minguez, José R; Iñiguez, Andrés; Zueco, Javier; Velazquez, Maite; Cequier, Angel; Lázaro-García, Rosa; Martí, Vicens; Moris, César; Urbano-Carrillo, Cristobal; Bastante, Teresa; Rivero, Fernando; Cárdenas, Alberto; Gonzalo, Nieves; Jiménez-Quevedo, Pilar; Fernández, Cristina

    2016-02-15

    Treatment of patients with in-stent restenosis (ISR) remains a challenge. This study sought to compare the efficacy of everolimus-eluting stents (EESs) and drug-eluting balloons (DEBs) with paclitaxel in patients with ISR. A pooled analysis of the Restenosis Intra-Stent of Drug-Eluting Stents: Drug-Eluting Balloon vs Everolimus-Eluting Stent (RIBS IV) and Restenosis Intra-Stent of Bare-Metal Stents: Drug-Eluting Balloon vs Everolimus-Eluting Stent (RIBS V) randomized trials was performed using patient-level data. In both trials, EESs were compared with DEBs in patients with ISR (RIBS V included 189 patients with bare-metal ISR; RIBS IV included 309 patients with drug-eluting ISR). Inclusion and exclusion criteria were identical in both trials. A total of 249 patients were allocated to EES and 249 to DEB. Clinical follow-up at 1 year was obtained in all (100%) patients and late angiography (median 249 days) in 91% of eligible patients. Compared with patients treated with DEBs, patients treated with EESs obtained better short-term results (postprocedural minimal lumen diameter 2.28 ± 0.5 vs 2.12 ± 0.4 mm, p stent type and treatment effects. At 1-year clinical follow-up, the composite of cardiac death, myocardial infarction, and target vessel revascularization was significantly reduced in the EES arm (8.8% vs 14.5%, p = 0.03; hazard ratio 0.59, 95% CI 0.31 to 0.94) mainly driven by a lower need for target vessel revascularization (6% vs 12.4%, p = 0.01, hazard ratio 0.46, 95% CI 0.25 to 0.86). This pooled analysis of the RIBS IV and RIBS V randomized trials demonstrates the superiority of EES over DEB in the treatment of patients with ISR.

  14. G-actin guides p53 nuclear transport: potential contribution of monomeric actin in altered localization of mutant p53

    Science.gov (United States)

    Saha, Taniya; Guha, Deblina; Manna, Argha; Panda, Abir Kumar; Bhat, Jyotsna; Chatterjee, Subhrangsu; Sa, Gaurisankar

    2016-01-01

    p53 preserves genomic integrity by restricting anomaly at the gene level. Till date, limited information is available for cytosol to nuclear shuttling of p53; except microtubule-based trafficking route, which utilizes minus-end directed motor dynein. The present study suggests that monomeric actin (G-actin) guides p53 traffic towards the nucleus. Histidine-tag pull-down assay using purified p53(1–393)-His and G-actin confirms direct physical association between p53 and monomeric G-actin. Co-immunoprecipitation data supports the same. Confocal imaging explores intense perinuclear colocalization between p53 and G-actin. To address atomistic details of the complex, constraint-based docked model of p53:G-actin complex was generated based on crystal structures. MD simulation reveals that p53 DNA-binding domain arrests very well the G-actin protein. Docking benchmark studies have been carried out for a known crystal structure, 1YCS (complex between p53DBD and BP2), which validates the docking protocol we adopted. Co-immunoprecipitation study using “hot-spot” p53 mutants suggested reduced G-actin association with cancer-associated p53 conformational mutants (R175H and R249S). Considering these findings, we hypothesized that point mutation in p53 structure, which diminishes p53:G-actin complexation results in mutant p53 altered subcellular localization. Our model suggests p53Arg249 form polar-contact with Arg357 of G-actin, which upon mutation, destabilizes p53:G-actin interaction and results in cytoplasmic retention of p53R249S. PMID:27601274

  15. G-actin guides p53 nuclear transport: potential contribution of monomeric actin in altered localization of mutant p53.

    Science.gov (United States)

    Saha, Taniya; Guha, Deblina; Manna, Argha; Panda, Abir Kumar; Bhat, Jyotsna; Chatterjee, Subhrangsu; Sa, Gaurisankar

    2016-01-01

    p53 preserves genomic integrity by restricting anomaly at the gene level. Till date, limited information is available for cytosol to nuclear shuttling of p53; except microtubule-based trafficking route, which utilizes minus-end directed motor dynein. The present study suggests that monomeric actin (G-actin) guides p53 traffic towards the nucleus. Histidine-tag pull-down assay using purified p53(1-393)-His and G-actin confirms direct physical association between p53 and monomeric G-actin. Co-immunoprecipitation data supports the same. Confocal imaging explores intense perinuclear colocalization between p53 and G-actin. To address atomistic details of the complex, constraint-based docked model of p53:G-actin complex was generated based on crystal structures. MD simulation reveals that p53 DNA-binding domain arrests very well the G-actin protein. Docking benchmark studies have been carried out for a known crystal structure, 1YCS (complex between p53DBD and BP2), which validates the docking protocol we adopted. Co-immunoprecipitation study using "hot-spot" p53 mutants suggested reduced G-actin association with cancer-associated p53 conformational mutants (R175H and R249S). Considering these findings, we hypothesized that point mutation in p53 structure, which diminishes p53:G-actin complexation results in mutant p53 altered subcellular localization. Our model suggests p53Arg249 form polar-contact with Arg357 of G-actin, which upon mutation, destabilizes p53:G-actin interaction and results in cytoplasmic retention of p53R249S. PMID:27601274

  16. The chrondoprotective actions of a natural product are associated with the activation of IGF-1 production by human chondrocytes despite the presence of IL-1β

    Directory of Open Access Journals (Sweden)

    Bobrowski Paul

    2006-04-01

    Full Text Available Abstract Background Cartilage loss is a hallmark of arthritis and follows activation of catabolic processes concomitant with a disruption of anabolic pathways like insulin-like growth factor 1 (IGF-1. We hypothesized that two natural products of South American origin, would limit cartilage degradation by respectively suppressing catabolism and activating local IGF-1 anabolic pathways. One extract, derived from cat's claw (Uncaria guianensis, vincaria®, is a well-described inhibitor of NF-κB. The other extract, derived from the vegetable Lepidium meyenii (RNI 249, possessed an uncertain mechanism of action but with defined ethnomedical applications for fertility and vitality. Methods Human cartilage samples were procured from surgical specimens with consent, and were evaluated either as explants or as primary chondrocytes prepared after enzymatic digestion of cartilage matrix. Assessments included IGF-1 gene expression, IGF-1 production (ELISA, cartilage matrix degradation and nitric oxide (NO production, under basal conditions and in the presence of IL-1β. Results RNI 249 enhanced basal IGF-1 mRNA levels in human chondrocytes by 2.7 fold, an effect that was further enhanced to 3.8 fold by co-administration with vincaria. Enhanced basal IGF-1 production by RNI 249 alone and together with vincaria, was confirmed in both explants and in primary chondrocytes (P Conclusion The identification of agents that activate the autocrine production of IGF-1 in cartilage, even in the face of suppressive pro-inflammatory, catabolic cytokines like IL-1β, represents a novel therapeutic approach to cartilage biology. Chondroprotection associated with prevention of the catabolic events and the potential for sustained anabolic activity with this natural product suggests that it holds significant promise in the treatment of debilitating joint diseases.

  17. Postoperative Nomogram for Predicting Cancer-Specific Mortality in Medullary Thyroid Cancer

    Science.gov (United States)

    Ho, Allen S.; Wang, Lu; Palmer, Frank L.; Yu, Changhong; Toset, Arnbjorn; Patel, Snehal; Kattan, Michael W.; Tuttle, R. Michael; Ganly, Ian

    2016-01-01

    Background Medullary thyroid cancer (MTC) is a rare thyroid cancer accounting for 5 % of all thyroid malignancies. The purpose of our study was to design a predictive nomogram for cancer-specific mortality (CSM) utilizing clinical, pathological, and biochemical variables in patients with MTC. Methods MTC patients managed entirely at Memorial Sloan-Kettering Cancer Center between 1986 and 2010 were identified. Patient, tumor, and treatment characteristics were recorded, and variables predictive of CSM were identified by univariable analyses. A multivariable competing risk model was then built to predict the 10-year cancer specific mortality of MTC. All predictors of interest were added in the starting full model before selection, including age, gender, pre- and postoperative serum calcitonin, pre- and postoperative CEA, RET mutation status, perivascular invasion, margin status, pathologic T status, pathologic N status, and M status. Stepdown method was used in model selection to choose predictive variables. Results Of 249 MTC patients, 22.5 % (56/249) died from MTC, whereas 6.4 % (16/249) died secondary to other causes. Mean follow-up period was 87 ± 67 months. The seven variables with the highest predictive accuracy for cancer specific mortality included age, gender, postoperative calcitonin, perivascular invasion, pathologic T status, pathologic N status, and M status. These variables were used to create the final nomogram. Discrimination from the final nomogram was measured at 0.77 with appropriate calibration. Conclusions We describe the first nomogram that estimates cause-specific mortality in individual patients with MTC. This predictive nomogram will facilitate patient counseling in terms of prognosis and subsequent clinical follow up. PMID:25366585

  18. Investigation on Internet addiction disorder in adolescents in Anhui, People’s Republic of China

    Directory of Open Access Journals (Sweden)

    Chen Y

    2016-08-01

    Full Text Available Yan Chen,1 Yaowen Kang,2 Weizhi Gong,3 Lianping He,1 Yuelong Jin,1 Xiaoyue Zhu,1 Yingshui Yao1 1School of Public Health, Wannan Medical College, Wuhu, Anhui, People’s Republic of China; 2Fushun Administrative College, Fushun, Liaoning, People’s Republic of China; 3Guangdong Polytechnic of Industry and Commerce, Guangzhou, People’s Republic of China Background and aim: The purpose of this study was to describe the characteristics and prevalence of Internet addiction (IA in adolescents so as to provide a scientific basis for the communities, schools, and families.Methods: We conducted a survey by randomized cluster sampling on 5,249 students, grades ranging from 7 to 12, in Anhui province, People’s Republic of China. The questionnaire consisted of general information and IA test. Chi-square test was used to compare the status of IA disorder (IAD.Results: In our results, the overall detection rate of IAD and non-IAD in students was 8.7% (459/5,249 and 76.2% (4,000/5,249, respectively. The detection rate of IAD in males (12.3% was higher than females (4.9%. The detection rate of IAD was statistically different between students from rural (8.2% and urban (9.3% areas, among students from different grades, between students from only-child families (9.5% and non-only-child families (8.1%, and among students from different family types.Conclusion: Prevalence of IA is high among Chinese adolescents. IAD has more effect on male students, single-child families, single-parent families, and higher grade students. We should take more care of male students, only-child students, and students living with their fathers, and related education should be strengthen for susceptible subjects of IDA. Keywords: adolescents, addictive behavior, Internet, health surveys 

  19. Mechanistic and computational studies of the reductive half-reaction of tyrosine to phenylalanine active site variants of D-arginine dehydrogenase.

    Science.gov (United States)

    Gannavaram, Swathi; Sirin, Sarah; Sherman, Woody; Gadda, Giovanni

    2014-10-21

    The flavin-mediated enzymatic oxidation of a CN bond in amino acids can occur through hydride transfer, carbanion, or polar nucleophilic mechanisms. Previous results with D-arginine dehydrogenase from Pseudomonas aeruginosa (PaDADH) using multiple deuterium kinetic isotope effects (KIEs) and computational studies established preferred binding of the substrate protonated on the α-amino group, with cleavages of the NH and CH bonds occurring in asynchronous fashion, consistent with the three possible mechanisms. The hydroxyl groups of Y53 and Y249 are ≤4 Å from the imino and carboxylate groups of the reaction product iminoarginine, suggesting participation in binding and catalysis. In this study, we have investigated the reductive half-reactions of the Y53F and Y249F variants of PaDADH using substrate and solvent deuterium KIEs, solvent viscosity and pH effects, and quantum mechanical/molecular mechanical computational approaches to gain insights into the catalytic roles of the tyrosines and evaluate whether their mutations affect the transition state for substrate oxidation. Both Y53F and Y249F enzymes oxidized D-arginine with steady-state kinetic parameters similar to those of the wild-type enzyme. Rate constants for flavin reduction (k(red)) with D-leucine, a slow substrate amenable to rapid kinetics, were 3-fold smaller than the wild-type value with similar pKa values for an unprotonated group of ∼10.0. Similar pKa values were observed for (app)Kd in the variant and wild-type enzymes. However, cleavage of the substrate NH and CH bonds in the enzyme variants occurred in synchronous fashion, as suggested by multiple deuterium KIEs on k(red). These data can be reconciled with a hydride transfer mechanism, but not with carbanion and polar nucleophilic mechanisms.

  20. Deuteron Photodissociation in Ultraperipheral Relativistic Heavy-Ion on Deuteron Collisions

    OpenAIRE

    Klein, Spencer; Vogt, Ramona

    2003-01-01

    In ultraperipheral relativistic deuteron on heavy-ion collisions, a photon emitted from the heavy nucleus may dissociate the deuterium ion. We find deuterium breakup cross sections of 1.38 barns for deuterium-gold collisions at a center of mass energy of 200 GeV per nucleon, as studied at the Relativistic Heavy Ion Collider, and 2.49 barns for deuterium-lead collisions at a center of mass energy of 6.2 TeV, as proposed for the Large Hadron Collider. This cross section includes an energy-indep...

  1. Er det noen forskjell i muskelaktiveringen ved bilaterale kontra unilaterale amerikanske kettlebell svinger i rectus abdominis, external oblique, erector spinae og multifidus?

    OpenAIRE

    Slåttland, Roy-André Vang; Vraalsen, Øyvind Fougli

    2013-01-01

    Formålet med denne studien var å undersøke muskelaktiveringen i kettlebell-sving ved unilateral og bilateral trening, i og med at dette ikke er gjort tidligere. Etter 2-5 tilvenningsøkter (til teknikken ble godkjent av sertifisert kettlebell-instruktør) ble 15 friske og styrketrente menn (alder 24,9 år ± 6,1, høyde 179,5 cm ± 6,8, og vekt 79,5 kg ± 7,95) testet i 10 repetisjoner unilateralt og bilateralt i randomisert rekkefølge. EMG- aktiviteten fra rectus abdominis, external oblique og erec...

  2. Atom-at-a-time radiochemical separations of the heaviest elements: Lawrencium chemistry

    International Nuclear Information System (INIS)

    The isotope 260Lr produced in reactions of 18O with 249Bk was used to perform chemical experiments on lawrencium to learn more about its chemical properties. These experiments involved extractions with thenoyl trifluoroacetate (TTA), ammonium alpha-hydroxyisobutyrate (HIB) elution from a cation exchange resin column, and reverse-phase chromatography using hydrogen di(2-ethylhexyl)orthophosphoric acid (HDEHP) to investigate the chemical properties of Lr. The results from the HIB elutions also give information about the ionic radius of Lr(III) which was found to elute very close to Er. An attempt to reduce Lr(III) was also made

  3. Core-shell ITO/ZnO/CdS/CdTe nanowire solar cells

    Science.gov (United States)

    Williams, B. L.; Taylor, A. A.; Mendis, B. G.; Phillips, L.; Bowen, L.; Major, J. D.; Durose, K.

    2014-02-01

    Radial p-n junction nanowire (NW) solar cells with high densities of CdTe NWs coated with indium tin oxide (ITO)/ZnO/CdS triple shells were grown with excellent heterointerfaces. The optical reflectance of the devices was lower than for equivalent planar films by a factor of 100. The best efficiency for the NW solar cells was η = 2.49%, with current transport being dominated by recombination, and the conversion efficiencies being limited by a back contact barrier (ϕB = 0.52 eV) and low shunt resistances (RSH < 500 Ω.cm2).

  4. Improving The Performance of Customer Loyalty of Online Ticketing in Indonesia's Showbiz Industry

    Science.gov (United States)

    Dachyar, M.; Athory, E. S.

    2015-06-01

    Currently the entertainment industry is adopting online ticketing for supporting business from main products to profitability improvement. E-loyalty needs to be examined because are deals with less loyal customer characteristic. The sample are 249 customers whom have purchased for tickets online at least once. Data was gathered by questionnaires and analyzed by Path Analysis and Importance - Performance Analysis. The findings of the research indicate that satisfaction has the strongest relationship to e-loyalty. This study provides four improvement alternatives as a form of new business development strategy for showbiz industry in Indonesia.

  5. The Music Effect

    DEFF Research Database (Denmark)

    Ridder, Hanne Mette Ochsner

    2006-01-01

    into music physiology. We have already seen them working together in 2001 in Berger’s book Music Therapy, Sensory Integration and the Autistic Child published by Jessica Kingsley, and this time their collaboration results in a book that is about the attributes of scientific reality (physics) as embedded......http://www.njmt.no/bookreview_2006071.html "The music effect is not about a particular composer, musical style, geographic location, language, or performance group. It is, at once, about all of these" (p. 249). This book is written by two people with very different educational backgrounds. Dr...

  6. The estimation of per capita loadings of domestic wastewater in Tehran

    OpenAIRE

    MESDAGHINIA, Alireza; Nasseri, Simin; Mahvi, Amir Hossein; Tashauoei, Hamid Reza; Mahdi HADI

    2015-01-01

    The amount of wastewater characteristics loading is one of the main parameters in the design of wastewater collection and treatment systems. The generation per capita per day (GPCD) of wastewater characteristics was estimated by analyzing the monthly data of nine wastewater treatment plants in Tehran, capital city of Iran. GPCD values were calculated from measured collected wastewater flow, the population and concentration data. The results indicated the values of 32.96 ± 1.91, 49.25 ± 2.49, ...

  7. Reinventing Significance: Reflections on Recent Whiteness Studies in Zimbabwe

    Directory of Open Access Journals (Sweden)

    Rory Pilossof

    2014-01-01

    Full Text Available Review Article: Josephine Lucy Fisher (2010, Pioneers, Settlers, Aliens, Exiles: The Decolonisation of White Identity in Zimbabwe, Canberra: Australian National University Press, ISBN 978-1-921-66614-8 (pbk., xiii + 276 pp. David McDermott Hughes (2010, Whiteness in Zimbabwe: Race, Landscape, and the Problem of Belonging, New York: Palgrave Macmillan, ISBN 978-0-230-62143-5 (pbk., 204 pp. Kate Victoria Law (2012, Writing White Women: Whiteness, Gender, Politics and Power in Rhodesia, c.1950s–1980s, Ph.D. thesis, University of Sheffield, 249 pp.

  8. Síntesis y estudios de caracterización preliminares de nuevos materiales Sonogel modificados con Nanocarbon

    OpenAIRE

    García Romero, Magdalena

    2015-01-01

    Los materiales sol-gel comenzaron a tomar protagonismo a mediados del s.XVIII con los estudios de Ebelman y Graham. Posteriormente, estos han sido ampliados por numerosos grupos de investigación, entre los cuales se encuentra el grupo de Instrumentación y Ciencias Ambientales (FQM- 249) del Departamento de Química Analítica de la Universidad de Cádiz, donde se han realizado diversos estudios sobre el Sonogel y el Sonogel-Carbono. La química del sol-gel proporciona un medio para...

  9. Morphological Behavior of Lipid Bilayers Induced by Melittin near the Phase Transition Temperature

    OpenAIRE

    Toraya, Shuichi; Nagao, Takashi; Norisada, Kazushi; Tuzi, Satoru; Saitô, Hazime; Izumi, Shunsuke; Naito, Akira

    2005-01-01

    Morphological changes of DMPC, DLPC, and DPPC bilayers containing melittin (lecithin/melittin molar ratio of 10:1) around the gel-to-liquid crystalline phase transition temperatures (Tc) were examined by a variety of biophysical methods. First, giant vesicles with the diameters of ∼20 μm were observed by optical microscopy for melittin-DMPC bilayers at 27.9°C. When the temperature was lowered to 24.9°C (Tc = 23°C for the neat DMPC bilayers), the surface of vesicles became blurred and dynamic ...

  10. TOPSwitch-GX series devices and their applications%TOPSwitch-GX开关电源器件

    Institute of Scientific and Technical Information of China (English)

    武林

    2001-01-01

    TOPSwitch-GX是美国Power Integrations公司的产品,TOP242-249是TOPSwitch-GX系列产品中可扩展功率、设计灵活、Ecosmart型集成离线式新型开关电源器件.本文阐述了TOPSwitch-GX的分类及性能特点和工作原理,并通过实例介绍了该器件在通用输入电源和微处理器远程开/关控制电路中的应用.

  11. TOPSwitch—GX开关电源器件

    Institute of Scientific and Technical Information of China (English)

    武林

    2001-01-01

    TOPSwitch-GX是美国Power Integrations公司的产品,TOP242-249是TOPSwitch-GX系列产品中可扩展功率、设计灵活、Ecosmart型集成离线式新型开关电源器件。本文阐述了TOPSwitch-GX的分类及性能特点和工作原理,并通过实例介绍了该器件在通用输入电源和微处理器远程开/关控制电路中的应用。

  12. p16 as a diagnostic marker of cervical neoplasia: a tissue microarray study of 796 archival specimens

    DEFF Research Database (Denmark)

    Lesnikova, Iana; Lidang, Marianne; Hamilton-Dutoit, Stephen;

    2009-01-01

    BACKGROUND: To evaluate the usefulness of this biomarker in the diagnosis of cases of cervical neoplasia we studied the immunohistochemical expression of p16INK4a in a large series of archival cervical biopsies arranged into tissue microarray format. METHODS: TMAs were constructed with tissue cores...... from archival formalin fixed, paraffin-embedded donor tissues from 796 patients, and included cases of cervical intraepithelial neoplasia (CIN)1 (n = 249), CIN2 (n = 233), CIN3 (n = 181), and invasive cervical carcinoma (n = 133). p16INK4a expression was scored using two different protocols: 1...

  13. Chorionic plate arterial function is altered in maternal obesity

    OpenAIRE

    Hayward, C.E.; Higgins, L.; Cowley, E.J.; Greenwood, S. l.; Mills, T.A.; Sibley, C. P.; Wareing, M.

    2013-01-01

    Objectives To characterise Chorionic Plate Artery (CPA) function in maternal obesity, and investigate whether leptin exposure reproduces the obese CPA phenotype in normal-BMI women. Study design CPA responses to the thromboxane-A2 mimetic U46619 (pre/post leptin incubation), to the nitric oxide donor sodium nitroprusside (SNP) and the occurrence of tone oscillations (pre/post leptin incubation) were assessed in 46 term placentas from women of normal (18.5–24.9) or obese (>30) Body Mass Index ...

  14. Search for an interstellar Si2C molecule: A theoretical prediction

    Indian Academy of Sciences (India)

    Suresh Chandra

    2004-09-01

    We suggest that Si2C molecule may be identified in astronomical objects through its transitions 414 → 505, 515 → 606, 212 → 303, 313 → 404, and 111 → 202 at 15.9, 5.1, 33.6, 24.9, and 42.3 GHz in absorption even against the cosmic 2.7 K background, in a region having low temperature. The absorption phenomenon is found rather large in the first two transitions. Dependence of results on the set of molecular parameters is discussed.

  15. Influence of elevated temperature and pCO2 on the marine periphytic diatom Navicula distans and its associated organisms in culture

    Digital Repository Service at National Institute of Oceanography (India)

    Baragi, L.V.; Khandeparker, L.; Anil, A.C.

    , U., D. A. Wolf-Gladrow & V. Smetacek, 1993. Carbon dioxide limitation of marine phytoplankton growth rates. Nature 361: 249–251. Riebesell, U., V. Fabry, L. Hansson & G. J-P, 2010. Guides to best practices for ocean acidification research... herbivores (Hawkins et al., 1992; Sommer, 1999); (b) a source of settlement cues for invertebrate larvae (Patil & Anil 2005a). Diatoms showed positive, negative or no response to elevated pCO2 (Johnson et al., 2013; Torstensson et al., 2012; Boelen et al...

  16. Colon,rectum and anus

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    2008303 MicroRNA expression profiling in hydrox-ycamptothecin-resistant human colon cancer cell line by microarray.TONG Jinlu(童锦禄), et al. Dept Gastroenterol, Renji Hosp, Med Sch, Shanghai Jiaotong Univ, Shanghai Instit Dig Dis, Shanghai 200001. Chin J Dig 2008;28(4):246-249.Objective To explore the role of a novel regulatory molecule-microRNA in the hydroxycamptothecin-resistant human colon cancer cell line SW1116/HCPTin order to provide a new reversal target for multidrug resistance.

  17. 激光科研应用

    Institute of Scientific and Technical Information of China (English)

    1998-01-01

    TN249 98053043强激光在高Z等离子体中吸收的波长关系=Wave—lenght dependence of absorption of laser lightin high—Z laser produced plasma[刊,中]/刘慎业,郑志坚,唐道源,腾浩,陈涵德,陈玉婷,苏春晓,张海英(西南核物理与化学研究所。四川,成都(610003))∥光学学报。—1998,18(3)。—318—323

  18. Efeito do potássio na fase de rustificação de mudas clonais de eucalipto

    OpenAIRE

    Flavio Siqueira D'Avila; Haroldo Nogueira de Paiva; Helio Garcia Leite; Nairam Félix de Barros; Fernando Palha Leite

    2011-01-01

    A aplicação de K está muitas vezes relacionada ao processo de rustificação, que tem por objetivo adaptar a muda às condições de plantio no campo. Neste sentido, este experimento foi conduzido visando avaliar o efeito do K na qualidade de mudas de três clones híbridos de Eucalyptus (E. grandis x E. urophylla). O experimento foi instalado no viveiro de mudas da empresa CENIBRA. As doses de potássio utilizadas foram: 0, 249, 747, 1494 e 2988 mg L-1. Aos 87 e 88 dias, foram avaliadas a altura da ...

  19. 78 FR 30800 - Reopening of Comment Periods for Certain Proposed Rulemaking Releases and Policy Statements...

    Science.gov (United States)

    2013-05-23

    ... COMMISSION 17 CFR Parts 240, 242, and 249 [Release No. 34-69491; File Nos. S7-27-10, S7-32-10, S7-34-10, S7-35- 10, S7-43-10, S7-03-11, S7-06-11, S7-08-11, S7-25-11, S7-40-11, S7-05- 12, S7-08-12] RIN 3235... Agreement Recordkeeping, Release No. 33-9338 (July 18, 2012); 77 FR 48208 (Aug. 13, 2012)......

  20. Report of the independent review commissioned by the Royal College of Radiologists into brachial plexus neuropathy following radiotherapy for breast carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Bates, Thelma; Evans, R.G.B.

    1995-12-31

    Brachial plexus neuropathy (BPN) is a rare but serious side effect of radiotherapy for operable breast carcinoma. It was identified in 48 of a sample of 126 patients (38%) who agreed to cooperate out of 249 members of RAGE, who were treated during the 14 year period 1980 to 1993 at 15 cancer centres. A conservative estimate of the total number of patients with operable breast cancer receiving radiotherapy at these centres during this time is 65,000. The incidence of BPN due to radiotherapy (BPN/RT) appears to be falling. From the first 7 years we found 41 cases and from the second 7 years only 7 cases. (author).

  1. AcEST: BP918005 [AcEST

    Lifescience Database Archive (English)

    Full Text Available . 31 2.8 sp|Q5R7P1|AGR2_PONAB Anterior gradient protein 2 homolog OS=Pong... 30 4...peroxidase OS=Xanthomonas axonopod... 30 6.1 sp|O95994|AGR2_HUMAN Anterior gradient protein 2 homolog OS=Hom...L PS+K T H Sbjct: 206 FSNKSANMDHWQQRFPTHVKDVATVCRQLAEKRMLDPSIKGTFH 249 >sp|Q5R7P1|AGR2_PONAB Anterior gradie...STSGKK 8 G+R ++A WQ+NQP+QL + T +R+Q + + GKK Sbjct: 502 GARIRLAPQKEWQANQPEQLAKVLATLERIQADFNAAQSGGKK 544 >sp|O95994|AGR2_HUMAN Anterior

  2. Acoustics of old Asian bells

    Science.gov (United States)

    Rossing, Thomas D.

    2001-05-01

    The art of casting bronze bells developed to a high level of sophistication in China during the Shang dynasty (1766-1123 BC). Many chimes of two-tone bells remain from the Western and Eastern Zhou dynasties (1122-249 BC). With the spread of Buddhism from the third century, large round temple bells developed in China and later in Korea, Japan, and other Asian countries. Vibrational modes of some of these bells have been studied by means of holographic interferometry and experimental modal testing. Their musical as well as acoustical properties are discussed.

  3. CHINA S NEW RECORD OF FOREIGN TRADE & ECONOMIC COOPERATION IN 2000

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The annual imp. & exp. value registered an increase of 31.5% over the previous year, amounting to USD 474.3 billion: USD 249.2 billion of exp. (increased by 27.8%) and USD 225.1 billion of imp. (up 35.8%). The imp.& exp.value of mechanic & electronic products reached USD 208.2 billion, an increase of 34.7%: USD 102.9 billion in imp. (increased by 32.6%) and USD 105.3 billion in exp. (increased by 36.9% up to 42.3% of total

  4. Design of an interactive game-based application for improving the resolution of common Computer Network issues

    Directory of Open Access Journals (Sweden)

    Mario Ciau Uitzil

    2012-11-01

    Full Text Available The need to find new ways to help students in the learning process makes us more involved with technology which evolves every day. This background leads us to find new methods and forms of teaching that help students accelerate their learning skills in a different way from the traditional, as in the case of learning through play, a concept that has been used in many games which have had great impact recently, becoming an innovative tool for learning. This paper shows the design of an interactive game-based application developed with Blender 2.49b tool to be implemented in the area of computer networks.

  5. Replacement of soybean meal by cottonseed meal 38% in multiple supplements for grazing beef heifers Substituição do farelo de soja por farelo de algodão 38% em suplementos múltiplos para novilhas de corte em pastejo

    OpenAIRE

    Barros, L. V.; Paulino, M. F.; S.C. Valadares Filho; Detmann, E.; F.G. Silva; E.E.L. Valente; Lopes, S. A.; MARTINS, L. S.

    2011-01-01

    The objective of this work was to evaluate the effect of using multiple supplements with different levels of cottonseed meal 38% on intake, total apparent digestibility of dietary components, efficiency of microbial synthesis and productive performance of beef heifers in Brachiaria decumbens pasture during the rainy season. It was used 25 Nellore heifers and 10 crossbred heifers with predominance of Zebu breed at 16 months of age and with 249.8 ± 0.6 kg of body weight. It was used a complete ...

  6. Somatotype, Body Composition and Proportionality in Polish Top Greco-Roman Wrestlers

    OpenAIRE

    Sterkowicz-Przybycień, Katarzyna L.; Sterkowicz, Stanisław; Żarów, Ryszard T.

    2011-01-01

    The objective of the paper was to determine body composition and somatotype of male Greco-Roman wrestlers grouped by different weight categories and level of competition. Twenty three contestants (aged 24.9±5.5 years, training experience 13.7±5.8 years) were examined during their competitive period. They were divided into heavier (n=12) and lighter weight categories (n=11).Twelve of them took part in Olympic Qualification Tournaments, whereas six others participated in the Olympic Games in At...

  7. Haunted Metre: Wordsworth’s Subliminal Lyric

    Directory of Open Access Journals (Sweden)

    Adrian HARDING

    2007-10-01

    Full Text Available Given Wordsworth’s condemnation, in the 1800 Preface to the Lyrical Ballads, of the “frantic novels, sickly and stupid German tragedies, and deluges of idle and extravagant stories in verse,” exciting the reading public’s “degrading thirst after outrageous stimulation” (LB 249, it has been customary to approach his relations to the Gothic in terms of readerships, grounded on or eventually grounding a sociology of reception. In this paper I am assuming the transference of the Gothic charge mo...

  8. Haunted Metre: Wordsworth’s Subliminal Lyric

    OpenAIRE

    Adrian HARDING

    2007-01-01

    Given Wordsworth’s condemnation, in the 1800 Preface to the Lyrical Ballads, of the “frantic novels, sickly and stupid German tragedies, and deluges of idle and extravagant stories in verse,” exciting the reading public’s “degrading thirst after outrageous stimulation” (LB 249), it has been customary to approach his relations to the Gothic in terms of readerships, grounded on or eventually grounding a sociology of reception. In this paper I am assuming the transference of the Gothic charge mo...

  9. Draft Genome Sequence of Methanoculleus sediminis S3FaT, a Hydrogenotrophic Methanogen Isolated from a Submarine Mud Volcano in Taiwan.

    Science.gov (United States)

    Chen, Sheng-Chung; Chen, Mei-Fei; Weng, Chieh-Yin; Lai, Mei-Chin; Wu, Sue-Yao

    2016-01-01

    Here, we announce the genome sequence of ITALIC! Methanoculleus sediminisS3Fa(T)(DSM 29354(T)), a strict anaerobic methanoarchaeon, which was isolated from sediments near the submarine mud volcano MV4 located offshore in southwestern Taiwan. The 2.49-Mb genome consists of 2,459 predicted genes, 3 rRNAs, 48 tRNAs, and 1 ncRNA. The sequence of this novel strain may provide more information for species delineation and the roles that this strain plays in the unique marine mud volcano habitat. PMID:27103730

  10. Domain Modeling: NP_009174.1 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_009174.1 chr6 Bacteriorhodopsin-like d1h2sa_ chr6/NP_009174.1/NP_009174.1_holo_10-249.pdb swppa 32R,35L,...36G,39P,67L,70L,71L,80M,101Y,114R,115Y,116W,121K,122G,124V,125L,143V,149W,152I,153F,156L,184K,191L,203L,...206V,207L,210V,221A,222F,229G,230L,239L,240R,243R BOG,RET 0 ...

  11. The association of gender, ethnicity, age, and education with Rorschach scores.

    Science.gov (United States)

    Meyer, Gregory J; Giromini, Luciano; Viglione, Donald J; Reese, Jennifer B; Mihura, Joni L

    2015-02-01

    We examined the association of gender, ethnicity, age, and education with 60 Rorschach scores using three clinical and nonclinical samples of adults and youths (ns = 640, 249, and 241). As anticipated for our data sets, there were no reliable associations for gender, ethnicity, or adult age. However, in adults years of education was associated with variables indicative of complexity, the articulation of subtlety and nuance, cognitive synthesis, and coping resources. In the clinical sample of youths, increasing age was primarily associated with more conventional perception and less illogical thought processes. Limitations are discussed in conjunction with further research that could address them, along with implications for applied practice. PMID:25059682

  12. Association of common ATM variants with familial breast cancer in a South American population

    Directory of Open Access Journals (Sweden)

    Peralta Octavio

    2008-04-01

    Full Text Available Abstract Background The ATM gene has been frequently involved in hereditary breast cancer as a low-penetrance susceptibility gene but evidence regarding the role of ATM as a breast cancer susceptibility gene has been contradictory. Methods In this study, a full mutation analysis of the ATM gene was carried out in patients from 137 Chilean breast cancer families, of which 126 were BRCA1/2 negatives and 11 BRCA1/2 positives. We further perform a case-control study between the subgroup of 126 cases BRCA1/2 negatives and 200 controls for the 5557G>A missense variant and the IVS38-8T>C and the IVS24-9delT polymorphisms. Results In the full mutation analysis we detected two missense variants and eight intronic polymorphisms. Carriers of the variant IVS24-9delT, or IVS38-8T>C, or 5557G>A showed an increase in breast cancer risk. The higher significance was observed in the carriers of IVS38-8T>C (OR = 3.09 [95%CI 1.11–8.59], p = 0.024. The IVS24-9 T/(-T, IVS38-8 T/C, 5557 G/A composite genotype confered a 3.19 fold increase in breast cancer risk (OR = 3.19 [95%CI 1.16–8.89], p = 0.021. The haplotype estimation suggested a strong linkage disequilibrium between the three markers (D' = 1. We detected only three haplotypes in the cases and control samples, some of these may be founder haplotypes in the Chilean population. Conclusion The IVS24-9 T/(-T, IVS38-8 T/C, 5557 G/A composite genotype alone or in combination with certain genetic background and/or environmental factors, could modify the cancer risk by increasing genetic inestability or by altering the effect of the normal DNA damage response.

  13. Crystal structure of 3-ethynyl-benzoic acid.

    Science.gov (United States)

    Venturini, Chiara; Ratel-Ramond, Nicolas; Gourdon, Andre

    2015-10-01

    In the title compound, C9H6O2, the carb-oxy-lic acid group is almost in the plane of the benzene ring, making a dihedral angle of 2.49 (18)°. In the crystal, mol-ecules are linked by pairs of O-H⋯O hydrogen bonds, forming classical acid-acid inversion dimers, with an R 2 (2)(8) ring motif. The dimers are linked by pairs of C-H⋯O hydrogen bonds forming chains, enclosing R 2 (2)(16) ring motifs, propagating along the c-axis direction. PMID:26594457

  14. Role of general practitioner in the management of acute myocardial infarction

    Directory of Open Access Journals (Sweden)

    Beeleonie Beeleonie

    2005-12-01

    Full Text Available Acute myocardial infarction (AMI has been the leading cause of death in Western countries, as well as in Indonesia. Delay in diagnosis and incorrect early management often result in failure of thrombolytic reperfusion. General practitioner (GP as the primary care, needs to be equipped with the ability to diagnose and moreover to manage AMI. A case of fail thrombolytic management in a 47 years old man after seven hours of angina typical chest pain, after previously managed by GP, is being reported. (Med J Indones 2005; 14:249-52Keywords: acute myocardial infarction, reperfusion, general practitioner

  15. Pulsed Excimer (KrF) Laser Melting of Amorphous and Crystalline Silicon Layers

    OpenAIRE

    Walthuis, A.; Stritzker, B.; White, C. W.; J. Narayan; Aziz, Michael

    1985-01-01

    We have investigated depth of melting as a function of pulse energy density in amorphous and crystalline silicon layers. The melting threshold for KrF laser pulses (lambda=0.249 µm, tau=24×10−9 s) in amorphous (7660-Å-thick) and crystalline silicon layers were determined to be 0.16±0.02 and 0.75±0.05 J cm−2, respectively. The formation of fine- and large-polycrystalline regions was clearly identified in the amorphous silicon layers for energy densities below that needed for complete annealing...

  16. Statistical analysis of thermospheric gravity waves from Fabry-Perot Interferometer measurements of atomic oxygen

    OpenAIRE

    E. A. K. Ford; A. L. Aruliah; Griffin, E. M.; I. McWhirter

    2008-01-01

    Data from the Fabry-Perot Interferometers at KEOPS (Sweden), Sodankyla (Finland), and Svalbard (Norway), have been analysed for gravity wave activity on all the clear nights from 2000 to 2006. A total of 249 nights were available from KEOPS, 133 from Sodankyla and 185 from the Svalbard FPI. A Lomb-Scargle analysis was performed on each of these nights to identify the periods of any wave activity during the night. Comparisons between many nights of data allow the general characteristics of the...

  17. Statistical analysis of thermospheric gravity waves from Fabry-Perot Interferometer measurements of atomic oxygen

    OpenAIRE

    E. A. K. Ford; A. L. Aruliah; Griffin, E. M.; I. McWhirter

    2008-01-01

    Data from the Fabry-Perot Interferometers at KEOPS (Sweden), Sodankylä (Finland), and Svalbard (Norway), have been analysed for gravity wave activity on all the clear nights from 2000 to 2006. A total of 249 nights were available from KEOPS, 133 from Sodankylä and 185 from the Svalbard FPI. A Lomb-Scargle analysis was performed on each of these nights to identify the periods of any wave activity during the night. Comparisons between many nights of data allow the general char...

  18. Drug: D00420 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D00420 Drug Mitotane (JAN/USP/INN); Lysodren (TN) C14H10Cl4 317.9537 320.0412 D0042...gents affecting individual organs 24 Hormones 249 Miscellaneous 2499 Others D00420 Mitotan...astic agents L01XX23 Mitotane D00420 Mitotane (JAN/USP/INN) USP drug classificati...on [BR:br08302] Hormonal Agents, Suppressant (Adrenal) Mitotane D00420 Mitotane (JAN/USP/INN) Target-based c...lassification of drugs [BR:br08310] Enzymes Oxidoreductases CYP17 [HSA:1586] [KO:K00512] Mitotane [ATC:L01XX23] D00420 Mitotan

  19. New Active Organic Substance in Oyster Shell Capable of Scavenging Oxygen Free Radicals with High Efficiency

    Institute of Scientific and Technical Information of China (English)

    MA Jian-hua

    2008-01-01

    A light purple organic active substance capable of scavenging hydroxyl radical·OH with a high efficiency was extracted from Oyster shell at an extraction rate of 2.49%.It was found for the first time that this active substance may scavenge ·OH with the efficiency far higher than that of vitamin C.This active substance may scavenge also superoxide radical(O2-·)although the scavenging efficiency is far lower than that of vitamin C.Infrared spectrometry and routine chemical analysis primarily reveal that this active substance belongs to glycoprotein.

  20. HIVAP calculations for the synthesis of new isotopes of Z=116 and Z=118 through 250Cm(48Ca, xn) and 250-252Cf(48Ca, xn) reactions

    International Nuclear Information System (INIS)

    The production and study of superheavy elements is an important area of research in contemporary experimental nuclear physics. The heaviest element produced so far is Z=118 (one isotope with A=294) in the 48Ca + 249Cf reaction with a production cross-section of 0.5 pico barns. Here we propose 250Cm(48Ca, xn) and 250-252Cf(48Ca, xn) reactions for the synthesis of heavier isotopes of Z=116 and 118 with comparable theoretical production cross-sections. 250Cm, 250Cf, 251Cf and 252Cf are feasible targets with half lives of 8300, 13.1, 898 and 2.6 years respectively