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Sample records for berit eika md

  1. Berit in Psalm 74

    Directory of Open Access Journals (Sweden)

    D.J. Human

    1995-09-01

    Full Text Available This article is an attempt to understand the concept berit in Psalm 74:20. Several possibilities regarding its significance and content were discussed by various biblical scholars. The vague reference to berit makes a convincing solution in this regard very difficult. A combination of allusions and motives in the Psalm which coincide with aspects of the Yahweh-David berit, strengthens the assumption that [foreign fornt omitted] (v 20 alludes to the loyalty and faithfulness of Yahweh which he promised in the berit with his servant David.

  2. Muscular Dystrophy (MD)

    Science.gov (United States)

    ... Awards Enhancing Diversity Find People About NINDS NINDS Muscular Dystrophy Information Page Clinical Trials Finding the Optimum Regimen ... en Español Additional resources from MedlinePlus What is Muscular Dystrophy? The muscular dystrophies (MD) are a group of ...

  3. Collide and Squeeze MD

    CERN Document Server

    Gorzawski, Arkadiusz; Papotti, Giulia; Salvachua Ferrando, Belen Maria; Wenninger, Jorg; Pieloni, Tatiana; CERN. Geneva. ATS Department

    2015-01-01

    Colliding the beams during the squeeze to profit from Landau damping due to head--on beam-beam and b* leveling are two operational modes that may have to be used in a not so distant future at the LHC. This MD aimed at improving the process control during the squeeze with much improved handling of reference for the orbit feedback system and at evaluating instruments and techniques to maintain the beam in collisions with active feedback on a good observable.

  4. Arnold Aberman, MD.

    Science.gov (United States)

    Aberman, A

    1995-10-01

    When the United States embarked on its effort to provide universal health insurance, the Canadian Medicare System was cited as a possible model for American health care. Often touted as an example of low-cost, high quality medicine, the Canadian system has mirrored the problems of health care across its southern border. With rocketing health care expenditures and financing having largely been decentralized to the individual provinces, local officials have struggled to cut costs and services. A central focus of these efforts has been a move to decrease the numbers of physicians, most notably a 10% decrease in medical school class size in 1993. While some Western provinces have experimented with the privatization of health care, the Canadian system still remains the epitome of government operated fee-for-service medicine. Given the likelihood of dramatic change in the American Medicare system, Canadian academic centers offer a unique perspective on the impact of capitation, evolving relationships with government payors, and the flip side of market oriented reforms. At the helm of one of Canada's largest schools is Arnold Aberman, MD, dean of the University of Toronto Faculty of Medicine. Born in Montreal, Quebec, Aberman received his MD from McGill University, but then did his residency both in Canada and the US, followed by a pulmonary fellowship at Albert Einstein College of Medicine and the Cardiovascular Research Institute of the University of California, San Francisco. Interviewed at his office in Toronto, Aberman reflected on the trials and tribulations confronting medicine on both sides of the 48th parallel.

  5. ADT fast losses MD

    CERN Document Server

    Priebe, A; Dehning, B; Redaelli, S; Salvachua Ferrando, BM; Sapinski, M; Solfaroli Camillocci, M; Valuch, D

    2013-01-01

    The fast beam losses in the order of 1 ms are expected to be a potential major luminosity limitation for higher beam energies after the LHC long shutdown (LS1). Therefore a Quench Test is planned in the winter 2013 to estimate the quench limit in this timescale and revise the current models. This experiment was devoted to determination the LHC Transverse Damper (ADT) as a system for fast losses induction. A non-standard operation of the ADT was used to develop the beam oscillation instead of suppressing them. The sign flip method had allowed us to create the fast losses within several LHC turns at 450 GeV during the previous test (26th March 2012). Thus, the ADT could be potentially used for the studies of the UFO ("Unidentied Falling Object") impact on the cold magnets. Verification of the system capability and investigations of the disturbed beam properties were the main objectives of this MD. During the experiment, the pilot bunches of proton beam were excited independently in the horizontal and vertical ...

  6. MD5算法研究%MD5 Algorithm

    Institute of Scientific and Technical Information of China (English)

    张裔智; 赵毅; 汤小斌

    2008-01-01

    随着网络技术的迅速发展,信息加密技术已成为保障网络安全的一种重要手段,加密算法已经成为人们的一个研究热点.本文对MD5算法进行了深入研究,介绍MD5算法的产生背景、应用及其算法流程,并提出了MD5算法的一个改进方案.

  7. 78 FR 14547 - Praxedes E. Alverez Santiago, M.D., Daniel Perez Brisebois, M.D., Jorge Grillasca Palou, M.D...

    Science.gov (United States)

    2013-03-06

    ... Praxedes E. Alverez Santiago, M.D., Daniel Perez Brisebois, M.D., Jorge Grillasca Palou, M.D., Rafael..., M.D., Daniel P rez Brisebois, M.D., Jorge Grillasca Palou, M.D., Rafael Garc a Nieves, M.D., Francis... and Dr. Daniel Perez, met with Humana representatives to discuss the 20 percent COB. During...

  8. MD 751: Train Instability Threshold

    CERN Document Server

    Carver, Lee Robert; Metral, Elias; Salvant, Benoit; Levens, Tom; Nisbet, David; Zobov, M; CERN. Geneva. ATS Department

    2016-01-01

    The purpose of this MD is to measure the octupole current thresholds for stability for a single bunch, and then make an immediate comparison (with the same operational settings) for a train of 72 bunches separated by 25ns. From theory, the expected thresholds should be similar. Any discrepancy between the two cases will be of great interest as it could indicate the presence of additional mechanisms that contribute to the instability threshold, for example electron cloud.

  9. Eesti Vabariigi põhiseadus : kommenteeritud väljaanne / toimetuskolleegium: Eerik-Juhan Truuväli, Berit Aaviksoo, Oliver Kask, Lasse Lehis, Lauri Madise, Ülle Madise, Kalle Merusk, Lauri Mälksoo, Raul Narits, Vallo Olle, Peep Pruks

    Index Scriptorium Estoniae

    2008-01-01

    Kommentaaride autorid ja sisu: Sissejuhatus / Raul Narits, Lauri Madise, Heinrich Schneider. Preambul / Raul Narits, Heinrich Schneider. I ptk. / Kalle Merusk, Taavi Annus, Madis Ernits, Heiki Lindpere, Lauri Madise. II ptk. / Oliver Kask, Madis Ernits, Taavi Annus, Peeter Roosma, Rait Maruste, Eerik Kergandberg, Ivo Pilving, Uno Lõhmus, Merilin Kiviorg, Einar Vene, Ülle Madise. III ptk. / Oliver Kask. IV ptk. / Lauri Madise, Aaro Mõttus, Jüri Põld, Tiina Runthal. V ptk. / Eerik-Juhan Truuväli, Ülle Madise, Jüri Põld, Urmas Reinsalu. VI ptk. / Kalle Merusk, Jüri Põld. VII ptk. / Eerik-Juhan Truuväli, Jüri Liventaal, Jüri Põld. VIII ptk. / Lasse Lehis. IX ptk. / Kristi Land, Heiki Lindpere, Lauri Madise, Heiki Pisuke. X ptk. / Oliver Kask, Enn Markvart, Jüri Põld. XI ptk. / Ülle Madise, Janek Laidvee, Heinrich Schneider. XII ptk. / Berit Aaviksoo, Mihkel Allik, Enn Markvart, Raul Narits, Aare Reenumägi, Peeter Roosma. XIII ptk. / Raul Narits, Uno Lõhmus, Madis Ernits, Jüri Põld. XIV ptk. / Vallo Olle, Arno Almann, Jüri Liventaal, Ülle Madise. XV ptk. / Eerik-Juhan Truuväli, Aaro Mõttus. Eesti Vabariigi põhiseaduse rakendamise seadus / Oliver Kask, Raul Narits, Peeter Roosma. Eesti Vabariigi põhiseaduse täiendamise seadus / Berit Aaviksoo, Julia Laffranque, Ülle Madise, Jüri Põld. Eesti Vabariigi põhiseadus 1990-2008 : bibliograafia (seisuga september 2008) / koost. Maia Ruttu

  10. Cavity Voltage Phase Modulation MD

    CERN Document Server

    Mastoridis, Themistoklis; Molendijk, John; Timko, Helga; CERN. Geneva. ATS Department

    2016-01-01

    The LHC RF/LLRF system is currently configured for extremely stable RF voltage to minimize transient beam loading effects. The present scheme cannot be extended beyond nominal beam current since the demanded power would exceed the peak klystron power and lead to saturation. A new scheme has therefore been proposed: for beam currents above nominal (and possibly earlier), the cavity phase modulation by the beam will not be corrected (transient beam loading), but the strong RF feedback and One-Turn Delay feedback will still be active for loop and beam stability in physics. To achieve this, the voltage set point will be adapted for each bunch. The goal of this MD was to test a new algorithm that would adjust the voltage set point to achieve the cavity phase modulation that would minimize klystron forward power.

  11. Cavity Voltage Phase Modulation MD

    CERN Document Server

    Mastoridis, T; Butterworth, A; Molendijk, J; Tuckmantel, J

    2012-01-01

    The LHC RF/LLRF system is currently setup for extremely stable RF voltage to minimize transient beam loading eects. The present scheme cannot be extended beyond nominal beam current since the demanded power would push the klystrons to saturation. For beam currents above nominal (and possibly earlier), the cavity phase modulation by the beam will be not be corrected (transient beam loading), but the strong RF feedback and One-Turn Delay feedback will still be active for loop and beam stability in physics. To achieve this, the voltage set point will be adapted for each bunch. The goal of this MD was to test an iterative algorithm that would adjust the voltage set point to achieve the optimal phase modulation for klystron forward power considerations.

  12. Fast Collision Attack on MD5

    NARCIS (Netherlands)

    Stevens, M.M.J.

    2006-01-01

    In this paper, we present an improved attack algorithm to find two-block collisions of the hash function MD5. The attack uses the same differential path of MD5 and the set of sufficient conditions that was presented by Wang et al. We present a new technique which allows us to deterministically fulfi

  13. Harvesting graphics power for MD simulations

    NARCIS (Netherlands)

    J.A. van Meel; A. Arnold; D. Frenkel; S.F. Portegies Zwart; R.G. Belleman

    2008-01-01

    We discuss an implementation of molecular dynamics (MD) simulations on a graphic processing unit (GPU) in the NVIDIA CUDA language. We tested our code on a modern GPU, the NVIDIA GeForce 8800 GTX. Results for two MD algorithms suitable for short-ranged and long-ranged interactions, and a congruentia

  14. Advances in Delta-md measurements

    OpenAIRE

    Ronga, Frederic Jean

    2003-01-01

    We report the current status of Delta-md measurements at B-factories. The most recent world average is Delta-md = 0.502+-0.007 1/ps (1.4% accuracy). An estimate of the errors for 500 1/fb data is also given.

  15. Obituary of Philip H. Cooper, MD.

    Science.gov (United States)

    Patterson, James W; Wick, Mark R; Mills, Stacey E

    2015-08-01

    Dermatopathology lost a giant in the field with the death of Philip H. Cooper, MD, on Friday, January 30, 2015. The following obituary represents a celebration of his life and his contributions to our field.

  16. Multi-Dimensional Games (MD-Games)

    OpenAIRE

    Ruiz Estrada, M.A.

    2009-01-01

    This paper introduces the concept of Multi-Dimensional games (MD-games) based on the application of an alternative mathematical and graphical modeling approach to study the game theory from a multi-dimensional perspective. In fact, the MD-Games request the application of the mega-space coordinate system to visualize a large number of games, players, strategies and pay-offs functions into the same graphical space.

  17. MD5算法的分析和改进%Analysis and Improvement of .MD5 Algorithm

    Institute of Scientific and Technical Information of China (English)

    么丽颖

    2011-01-01

    首先研究了MD5算法,并总结了MD5算法的特点及性能,在研究MD5算法的基础之上,提出了MD5改进加密算法.最后,对MD5算法与MD5改进算法对应于相关数据、性能进行了比较.%At first , MD5 algorithm is researched, and the characteristic and capability of the MD5 are summaried in the paper. The improved MD5 algorithm is put forward based on the research of the MDS. At last, the contrast between MD5 algorithm and the improved MD5 algorithm in related datum and capability are put forward.

  18. New Message Differences for Collision Attacks on MD4 and MD5

    Science.gov (United States)

    Sasaki, Yu; Wang, Lei; Kunihiro, Noboru; Ohta, Kazuo

    In 2005, collision resistance of several hash functions was broken by Wang et al. The strategy of determining message differences is the most important part of collision attacks against hash functions. So far, many researchers have tried to analyze Wang et al.'s method and proposed improved collision attacks. Although several researches proposed improved attacks, all improved results so far were based on the same message differences proposed by Wang et al. In this paper, we propose new message differences for collision attacks on MD4 and MD5. Our message differences of MD4 can generate a collision with complexity of less than two MD4 computations, which is faster than the original Wang et al.'s attack, and moreover, than the all previous attacks. This is the first result that improves the complexity of collision attack by using different message differences from Wang et al.'s. Regarding MD5, so far, no other message difference from Wang et al.'s is known. Therefore, study for constructing method of other message differences on MD5 should be interesting. Our message differences of MD5 generates a collision with complexity of 242 MD5 computations, which is slower than the latest best attack. However, since our attack needs only 1 bit difference, it has some advantages in terms of message freedom of collision messages.

  19. Fast Collision Attack on MD5

    OpenAIRE

    Stevens, Marc

    2006-01-01

    In this paper, we present an improved attack algorithm to find two-block collisions of the hash function MD5. The attack uses the same differential path of MD5 and the set of sufficient conditions that was presented by Wang et al. We present a new technique which allows us to deterministically fulfill restrictions to properly rotate the differentials in the first round. We will present a new algorithm to find the first block and we will use an algorithm of Klima to find the second block. To o...

  20. Filmifestival ootab dokfilme uudistama / Berit Toodo

    Index Scriptorium Estoniae

    Toodo, Berit

    2008-01-01

    Pärnu 22. dokumentaal- ja antropoloogiafilmide festivali kulgemisest, probleemidest filmide näitamise paikade ja tehnikaga, näidatavate filmide tutvustusi - ameeriklase Robert Harding Pittmani "Tamm nr. 419", Doris Tromballa ja Florian Guthknechti "Elu tulvavees", hollandlase Jos de Putteri "Enne üleujutust"

  1. 78 FR 2707 - Maryland Disaster # MD-00026

    Science.gov (United States)

    2013-01-14

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Maryland Disaster MD-00026 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY... Deadline Date: 10/02/2013. ADDRESSES: Submit completed loan applications to: U.S. Small...

  2. Direct NOE simulation from long MD trajectories

    Science.gov (United States)

    Chalmers, G.; Glushka, J. N.; Foley, B. L.; Woods, R. J.; Prestegard, J. H.

    2016-04-01

    A software package, MD2NOE, is presented which calculates Nuclear Overhauser Effect (NOE) build-up curves directly from molecular dynamics (MD) trajectories. It differs from traditional approaches in that it calculates correlation functions directly from the trajectory instead of extracting inverse sixth power distance terms as an intermediate step in calculating NOEs. This is particularly important for molecules that sample conformational states on a timescale similar to molecular reorientation. The package is tested on sucrose and results are shown to differ in small but significant ways from those calculated using an inverse sixth power assumption. Results are also compared to experiment and found to be in reasonable agreement despite an expected underestimation of water viscosity by the water model selected.

  3. MD on UFOs at MKIs and MKQs

    CERN Document Server

    Baer, T; Bartmann, W; Bracco, C; Carlier, E; Dehning, B; Garrel, N; Goddard, B; Jackson, S; Jimenez, M; Kain, V; Mertens, V; Misiowiec, M; Nordt, A; Papotti, G; Uythoven, J; Wenninger, J; Zerlauth, M; Zamantzas, C; Zimmermann, F

    2012-01-01

    UFOs ("Unidentified Falling Objects") are expected to be one of the major known performance limitation of the LHC. In this MD, the production mechanism and the dynamics of UFOs at the injection kicker magnets (MKIs) and the tune kicker magnets (MKQs) were studied. This was done by pulsing the MKIs and MKQs on a gap in the partly filled machine. During the MD, in total 58 UFO-type beam loss patterns were observed directly after pulsing the MKIs. None were observed after pulsing the MKQs, which provides important input for possible mitigation strategies. The temporal and spatial distribution of the UFO events could be determined by using a dedicated BLM Study Buffer, the implications for the UFO dynamics are discussed.

  4. MD5的Keygenme分析

    Institute of Scientific and Technical Information of China (English)

    Firebig

    2006-01-01

    闲来无事,抓出个不知何时下的Keygenme练练手,分析后可知.这个Keygenme有2张数据表,由注册名经MD5运算后进行查表,得出2个DWORD数据.然后再由注册码经过一个可逆循环得出2个DWORD数据.最后对比是否正确。(MD5的具体介绍黑防6期有说明)

  5. Integrative Medicine Program- MD Anderson Cancer Center

    OpenAIRE

    Lee, Richard T.

    2012-01-01

    The Integrative Medicine Program at MD Anderson Cancer Center was first established in 1998.  Our mission is to empower patients with cancer and their families to become active partners in their own physical, psycho-spiritual, and social health through personalized education and evidenced-based clinical care to optimize health, quality of life, and clinical outcomes across the cancer continuum.  The program consists of three main components: clinical care, research, and education.  The Integr...

  6. Classical MD calculations with parallel computers

    Energy Technology Data Exchange (ETDEWEB)

    Matsumoto, Mitsuhiro [Nagoya Univ. (Japan)

    1998-03-01

    We have developed parallel computation codes for a classical molecular dynamics (MD) method. In order to use them on work station clusters as well as parallel super computers, we use MPI (message passing interface) library for distributed-memory type computers. Two algorithms are compared: (1) particle parallelism technique: easy to install, effective for rather small number of processors. (2) region parallelism technique: take some time to install, effective even for many nodes. (J.P.N.)

  7. ProtoMD: A prototyping toolkit for multiscale molecular dynamics

    Science.gov (United States)

    Somogyi, Endre; Mansour, Andrew Abi; Ortoleva, Peter J.

    2016-05-01

    ProtoMD is a toolkit that facilitates the development of algorithms for multiscale molecular dynamics (MD) simulations. It is designed for multiscale methods which capture the dynamic transfer of information across multiple spatial scales, such as the atomic to the mesoscopic scale, via coevolving microscopic and coarse-grained (CG) variables. ProtoMD can be also be used to calibrate parameters needed in traditional CG-MD methods. The toolkit integrates 'GROMACS wrapper' to initiate MD simulations, and 'MDAnalysis' to analyze and manipulate trajectory files. It facilitates experimentation with a spectrum of coarse-grained variables, prototyping rare events (such as chemical reactions), or simulating nanocharacterization experiments such as terahertz spectroscopy, AFM, nanopore, and time-of-flight mass spectroscopy. ProtoMD is written in python and is freely available under the GNU General Public License from github.com/CTCNano/proto_md.

  8. Integrative Medicine Program- MD Anderson Cancer Center

    Directory of Open Access Journals (Sweden)

    Richard T Lee

    2012-06-01

    Full Text Available The Integrative Medicine Program at MD Anderson Cancer Center was first established in 1998.  Our mission is to empower patients with cancer and their families to become active partners in their own physical, psycho-spiritual, and social health through personalized education and evidenced-based clinical care to optimize health, quality of life, and clinical outcomes across the cancer continuum.  The program consists of three main components: clinical care, research, and education.  The Integrative Medicine Center provides clinical services to patients through individual and group programs.  The clinical philosophy of the center is to work collaboratively with the oncology teams to build comprehensive and integrative care plans that are personalized, evidence-based, and safe with the goal of improving clinical outcomes.  The individual services comprise of integrative oncology consultation, acupuncture, meditation, music therapy, nutrition, and oncology massage.  The center also provides a variety of group programs including meditation, yoga, tai chi, cooking classes and others.  Over the past 13 years, over 70,000 patients and families have participated in services and programs offered by the center.  The research portfolio focuses on three main areas: mind-body interventions, acupuncture, and meditation.  This lecture will focus on providing an overview of the Integrative Medicine Program at MD Anderson with a focus on the clinical services provided.  Participants will learn about the integrative clinical model and how this is applied to the care of cancer patients at MD Anderson Cancer Center.  Current and future research topics will be discussed as well as patient cases.

  9. MD Test of a Ballistic Optics

    CERN Document Server

    Garcia-Tabares Valdivieso, Ana; Salvachua Ferrando, Belen Maria; Skowronski, Piotr Krzysztof; Solfaroli Camillocci, Matteo; Tomas Garcia, Rogelio; Wenninger, Jorg; Coello De Portugal - Martinez Vazquez, Jaime Maria; CERN. Geneva. ATS Department

    2016-01-01

    The ballistic optics is designed to improve the understanding of optical errors and BPM systematic effects in the critical triplet region. The particularity of that optics is that the triplet is switched off, effectively transforming the triplets on both sides of IR1 and IR5 into drift spaces. Advantage can be taken from that fact to localize better errors in the Q4-Q5-triplet region. During this MD this new optics was tested for the first time at injection with beam 2.

  10. 76 FR 1993 - Airworthiness Directives; The Boeing Company Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD...

    Science.gov (United States)

    2011-01-12

    ... (75 FR 34661). That NPRM proposed to require installing fuel level float and pressure switch in-line... 12866, (2) Is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034... Maintenance Manual (AMM) defueling procedure MD80 AMM 12-13-00. The correct reference is Boeing MD80 AMM...

  11. ProtoMD: A prototyping toolkit for multiscale molecular dynamics

    Science.gov (United States)

    Somogyi, Endre; Mansour, Andrew Abi; Ortoleva, Peter J.

    2016-05-01

    ProtoMD is a toolkit that facilitates the development of algorithms for multiscale molecular dynamics (MD) simulations. It is designed for multiscale methods which capture the dynamic transfer of information across multiple spatial scales, such as the atomic to the mesoscopic scale, via coevolving microscopic and coarse-grained (CG) variables. ProtoMD can be also be used to calibrate parameters needed in traditional CG-MD methods. The toolkit integrates 'GROMACS wrapper' to initiate MD simulations, and 'MDAnalysis' to analyze and manipulate trajectory files. It facilitates experimentation with a spectrum of coarse-grained variables, prototyping rare events (such as chemical reactions), or simulating nanocharacterization experiments such as terahertz spectroscopy, AFM, nanopore, and time-of-flight mass spectroscopy. ProtoMD is written in python and is freely available under the GNU General Public License from

  12. MD5算法在Web开发中的应用%Application of MD5 in Web Exploitation

    Institute of Scientific and Technical Information of China (English)

    刘啸

    2014-01-01

    介绍了MD5加密技术在Web上的一些应用,给出了MD5加密实现密码在internet上安全传输的完整解决办法,给出了客户端(JavaScript)和服务器端(JavaBeans) MD5算法的实现.

  13. 33 CFR 110.72 - Blackhole Creek, Md.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Blackhole Creek, Md. 110.72... ANCHORAGE REGULATIONS Special Anchorage Areas § 110.72 Blackhole Creek, Md. The waters on the west side of Blackhole Creek, a tributary of Magothy River, southwest of a line bearing 310°30′ from the most...

  14. 76 FR 51887 - Safety Zone; Patuxent River, Patuxent River, MD

    Science.gov (United States)

    2011-08-19

    ...) entitled ``Safety Zone; Patuxent River, Patuxent River, MD'' in the Federal Register (76 FR 36447). We... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Patuxent River, Patuxent River, MD AGENCY... safety zone during the ``NAS Patuxent River Air Expo '11,'' which consists of aerial...

  15. BI MD studies on August 25th 2011

    CERN Document Server

    Belohrad, D; Boccardi, A; Calvo, E; Dehning, B; Favier, M; Emery, J; Guerrero, A; Lefevre, T; Gras, JJ; Jeff, A; Soby, L; Rabiller, A; Roncarolo, F; Sapinski, M; Steinhagen, R; Mateo, CM

    2011-01-01

    This note contains the preliminary results of the LHC MD that took place on 25-Aug-2011 (from 5 a.m. to 1 p.m.), dedicated to study Beam Loss Monitors (BLM), Wire Scanners (WS), Synchrotron Radiation (BSRT), Beam Position Monitors (BPM), and Beam Gas Ionization (BGI) monitors. The MD aimed at performing different studies on the individual monitors.

  16. MD5密码极速爆破

    Institute of Scientific and Technical Information of China (English)

    飘零雪

    2009-01-01

    MD5加密技术对我们来说并不陌生,通过MD5值可以校验下载软件的安全性,而且在很多系统中,用户的密码是以MD5值的方式保存的,用户登录时系统是把用户输入的密码计算成MD5值,然后再去和系统中保存的MD5值进行比较,以验证该用户的合法性。MD5值虽看似很安全,但也并非无懈可击,使用“超速md5破解工具”即可简单快捷地尝试解密MD5。

  17. Single-block collision attack on MD5

    NARCIS (Netherlands)

    Stevens, M.M.J.

    2012-01-01

    In 2010, Tao Xie and Dengguo Feng \\cite{cryptoeprint:2010:643} constructed the first single-block collision for MD5 consisting of two 64-byte messages that have the same MD5 hash. Details of their attack, developed using what they call an evolutionary approach, has not been disclosed ``for security

  18. Chosen-Prefix Collisions for MD5 and Applications

    NARCIS (Netherlands)

    Stevens, M.M.J.; Lenstra, A.K.; Weger, B. de

    2012-01-01

    We present a novel, automated way to find differential paths for MD5. Its main application is in the construction of \\emph{chosen-prefix collisions}. We have shown how, at an approximate expected cost of $2^{39}$ calls to the MD5 compression function, for any two chosen message prefixes $P$ and $P'$

  19. Leroy D Vandam, MD: an anesthesia journey.

    Science.gov (United States)

    Ortega, Rafael A

    2005-08-01

    Leroy D Vandam, MD was a remarkable man--an intricate amalgamation of an artist, scientist, and physician. He was a bastion of medical historical knowledge. Dr Vandam became a most influential anesthesiologist, some say, a giant. He was an example of someone who, with resolve, overcame adversity. His artwork is displayed in countless places, and several of his paintings form part of the Wood Library Museum Heritage Series. Dr Vandam was first a surgeon, but he abandoned surgery and pursued a career in anesthesiology under the leadership of Robert Dripps. He completed his residency training at the University of Pennsylvania and joined its staff in 1949. When he arrived at Brigham and Women's Hospital in the 1950s as director of anesthesia, he embarked on one of the most illustrious careers in American anesthesiology. Dr Vandam published more than 250 original articles, chapters, abstracts, and other reports on a wide variety of subjects including history, art, and pharmacology. His classic article on the complications of neuroaxial blocks is a seminal work in anesthesiology. This article describes how an anesthesiologist who shared an interest with Dr Vandam in the history of anesthesiology came to produce a movie based on his career, the evolution of anesthesia equipment, and the transformation of our specialty.

  20. DFT-MD simulations of shocked Xenon

    Science.gov (United States)

    Magyar, Rudolph J.; Mattsson, Thomas R.

    2009-03-01

    Xenon is not only a technologically important element used in laser technologies, jet propulsion and dental anesthesia, but it is also arguably the simplest material in which to study the metal-insulator transition at high pressure. Because of its closed shell electronic configuration, Xenon is often assumed to be chemically inert, interacting almost entirely through the van der Waals interaction, and at liquid density, is typically modeled well using Leonard-Jones potentials. However, such modeling has a limited range of validity as Xenon is known to form compounds at normal conditions and likely exhibits considerably more chemistry at higher densities when hybridization of occupied orbitals becomes significant. In this talk, we present DFT-MD simulations of shocked liquid Xenon with the goal of developing an improved equation of state. The relative importance of the van der Waals interaction compared to other Coulomb interactions is considered, and estimates of the relative accuracy of various density functionals are quantified. Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000.

  1. MD-PhD training: looking back and looking forward.

    Science.gov (United States)

    Bonham, Ann C

    2014-01-01

    MD-PhD programs provide rigorous, integrated training for physician-scientists, enabling them to frame scientific questions in unique ways and to apply clinical insight to fundamental science. Few would question the influential contributions of MD-PhD physician-scientists in advancing medical science. In this issue of Academic Medicine, Jeffe et al affirm high levels of excellence in educational outcomes from MD-PhD training programs at U.S. MD-granting medical schools, especially programs that receive funding from the NIH Medical Scientist Training Program (MSTP). The author of this commentary observes that, in the face of current economic pressures, comprehensive, longitudinal national outcomes data from MSTP- and non-MSTP-funded MD-PhD programs will help verify the value provided by MD-PhD physician-scientists. She proposes that MD-PhD programs should better prepare the next generation of physician-scientists for future research environments, which will provide new technologies, venues, and modalities. These research environments will be more closely integrated within health care delivery systems, extend into diverse communities and regions, and employ complex technologies. MD-PhD physician-scientists also will train and gain expertise in broadening areas of research, such as health policy, health economics, clinical epidemiology, and medical informatics. Program leaders are ideally situated to foster innovative learning environments and methodologies. By sharing their innovations, they can help ensure production of a diverse MD-PhD physician-scientist workforce, prepared to engage in myriad research opportunities to meet patient and population needs in a new environment.

  2. MD 239 on Collide and Squeeze (part 2)

    CERN Document Server

    Gorzawski, Arkadiusz; Salvachua Ferrando, Belen Maria; Wenninger, Jorg; CERN. Geneva. ATS Department

    2016-01-01

    Colliding the beams during the squeeze to profit from Landau damping due to head--on beam-beam and beta--star leveling are two operational modes that may have to be used in a not so distant future at the LHC. This MD aimed at improving the orbit control during the squeeze with much improved handling of orbit feedback references and at evaluating instruments and techniques to maintain the beam in collisions with active feedback on luminosity or beam position. This MD also integrated for the first time synchronized collimator measurements. Comparison of the settings with the previous MD allowed a validation of the long term stability of collide and squeeze.

  3. Single-block collision attack on MD5

    OpenAIRE

    Stevens, Marc

    2012-01-01

    In 2010, Tao Xie and Dengguo Feng \\cite{cryptoeprint:2010:643} constructed the first single-block collision for MD5 consisting of two 64-byte messages that have the same MD5 hash. Details of their attack, developed using what they call an evolutionary approach, has not been disclosed ``for security reasons''. Instead they have posted a challenge to the cryptology community to find a new different single-block collision attack for MD5. This paper answers that challenge by presenting a single-b...

  4. MD5加密算法的研究

    Institute of Scientific and Technical Information of China (English)

    许琪

    2014-01-01

    MD5加密算法做为散列函数的一个重要算法,在文件校验、数字签名等诸多领域有着广泛的应用.虽然MD5加密算法是单向算法,但其仍无法抵御差分攻击和查字典攻击.文章在分析了差分攻击原理的基础上,阐述了MD5加密算法采用差分攻击产生碰撞的方法.

  5. Charge separation reaction in clusters of polar molecules. MD simulations

    International Nuclear Information System (INIS)

    Rate constant of intermolecular electron transfer (ET) in a photoexcited donor-acceptor model system solvated by a cluster of polar molecules has been expressed in terms of the statistical distribution of the electrostatic potential energy difference between the reacting sites. This distribution has been calculated for a particular case of acetonitrile clusters at ∼ 120 K by MD computer simulation. The MD values of the cluster reorganization energy and the ET rate constant have been compared with the corresponding MD results for the donor-acceptor pair solvated in bulk acetonitrile and with theoretical predictions based on the continuum model. (author)

  6. MD5Hash加密算法在SQL Server2005中的应用%Application of MD5 Hash Encryption Algorithm in SQL Server 2005

    Institute of Scientific and Technical Information of China (English)

    李红日

    2011-01-01

    在对MD5算法进行简要描述的同时,对MD5算法的原理作深入分析.介绍在C创建MD5 Hash算法的函数,在SQL Server中应用MD5哈希算法,并且经过测试可以准确实现MD5 Hash加密算法.

  7. Cryptanalysis of the Hash Function MD5%关于Hash函数MD5的解析

    Institute of Scientific and Technical Information of China (English)

    毛明; 陈少晖; 袁征; 贾永兴

    2009-01-01

    This paper is about the cryptanalysis of the Hash function MDS, on the basis of the paper concerning the breaking the MD5 which was written by Wang et al.In this paper,the eighth step of MD5 algorithm was taken for exam-ple and the properties of the F function and the effective control of the differential path were introduced.The MD5 algo-rithm was cryptanalyzed from both the manual calculation and the testing program and some part of the paper written by Wang was amended.Finally, the conditions and key points of meeting the differential characteristics were discussed.In general, this paper plays an important role in eryptanalyzing and breaking the MD5 algorithm.%在王小云写的关于分析MD5算法文章的基础上,对MD5算法的破译进行进一步的解析.以MD5算法第八步为例,介绍了F函数的性质和差分路径的有效控制.从手工推算和程序实现两方面时MD5算法进行了解析和测试,对王的文章进行了部分修正,进一步说明了满足差分特征的条件和关键点.这对MD5和其他Hash函数的分析破译有着重要的作用.

  8. Find an Orthopaedic Foot and Ankle MD/DO

    Science.gov (United States)

    ... page. Home Contact Us FootCareMD Currently selected About Us Overview of Foot & Ankle Glossary of Foot & Ankle Terms Adult Foot Health ... Map American Orthopaedic Foot & Ankle Society ® Orthopaedic Foot ... US) Copyright © 2016 All Rights Reserved

  9. Autentikasi Pesan Menggunakan Algoritma Message Digest 5 (MD5)

    OpenAIRE

    Simamora, Ali Makmur

    2015-01-01

    When receive or send a message on the network internet, there are some issue which very important namely problem wholeness and authentication. This script discusses about authentication of message with Message Digest algorithm 5. The writter designed an application to ensure the integrity of the message by algorithm MD5. MD5 is a tool to declare the validity of (authentic) sent messages as well as message. To express validity of message in the text or file will used encryption method, so the ...

  10. Waiting time distribution in M/D/1 queueing systems

    DEFF Research Database (Denmark)

    Iversen, Villy Bæk; Staalhagen, Lars

    1999-01-01

    The well-known formula for the waiting time distribution of M/D/1 queueing systems is numerically unsuitable when the load is close to 1.0 and/or the results for a large waiting time are required. An algorithm for any load and waiting time is presented, based on the state probabilities of M/D/1....... The principles are also applicable for other queueing systems...

  11. Research of the Hash Algorithm Based on MD5%MD5散列算法的研究

    Institute of Scientific and Technical Information of China (English)

    姜学军; 曹烨

    2014-01-01

    借鉴了M.M.J.Stevens的碰撞思路,重新编写了MD5碰撞算法中的核心循环,主要提供一对MD5碰撞产生的过程以及碰撞的完成.通过实验统计分析,利用改进的MD5碰撞算法找到一对碰撞信息所用平均时间不多于60s,且该算法较之传统的MD5碰撞算法具有更好的可读性和可移植性.

  12. 基于MD5和Session的PHP安全防范%PHP security based on Session and MD5

    Institute of Scientific and Technical Information of China (English)

    何秉荣

    2014-01-01

    根据Session工作原理和MD5算法的特性,分析了PHP中Session欺骗与攻击手段,并较有针对性地在防范Session攻击的技术中结合MD5函数,从而提出了一个较为有效、实用的防范措施.

  13. Cummins MD & HD Accessory Hybridization CRADA -Annual Report FY15

    Energy Technology Data Exchange (ETDEWEB)

    Deter, Dean D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-10-01

    There are many areas of MD and HD vehicles that can be improved by new technologies and optimized control strategies. Component optimization and idle reduction need to be addressed, this is best done by a two part approach that includes selecting the best component technology, and/or architecture, and optimized controls that are vehicle focused. While this is a common focus in the light duty industry it has been gaining momentum in the MD and HD market as the market gets more competitive and the regulations become more stringent. When looking into systems optimization and idle reduction technologies, affected vehicle systems must first be considered, and if possible included in the new architecture to get the most benefit out of these new capabilities. Typically, when looking into idle reduction or component optimization for MD/HD, the vehicle s accessories become a prime candidate for electrification or hybridization. While this has already been studied on light duty vehicles (especially on hybrids and electric vehicles) it has not made any head way or market penetration in most MD and HD applications. If hybrids and electric MD and HD vehicles begin to break into the market this would be a necessary step into the ability to make those vehicles successful by allowing for independent, optimized operation separate from the engine.

  14. 基于C#的MD5加密算法的应用%Application of the MD5 algorithm based on C#

    Institute of Scientific and Technical Information of China (English)

    林宗朝

    2011-01-01

    介绍了WEB SYSTEM中的密钥安全性能。主要讨论了WEB SYSTEM中MD5加密算法,包含客户password安全性分析、MD5加密算法概述、基于C#的MD5加密应用介绍,以及IT SYSTEM中MD5算法的应用与IMPROVEMENT等问题。%The key safety properties of the WEB system is described,and the.MD5 encryption algorithm is discussed mainly including the user password security analysis,MD5 encryption algorithm summary,MD5 encryption applications based on the C# and the improvement of MD5 algorithm.

  15. CoMD Implementation Suite in Emerging Programming Models

    Energy Technology Data Exchange (ETDEWEB)

    2014-09-23

    CoMD-Em is a software implementation suite of the CoMD [4] proxy app using different emerging programming models. It is intended to analyze the features and capabilities of novel programming models that could help ensure code and performance portability and scalability across heterogeneous platforms while improving programmer productivity. Another goal is to provide the authors and venders with some meaningful feedback regarding the capabilities and limitations of their models. The actual application is a classical molecular dynamics (MD) simulation using either the Lennard-Jones method (LJ) or the embedded atom method (EAM) for primary particle interaction. The code can be extended to support alternate interaction models. The code is expected ro run on a wide class of heterogeneous hardware configurations like shard/distributed/hybrid memory, GPU's and any other platform supported by the underlying programming model.

  16. BI MD Studies on June 29th 2011

    CERN Document Server

    Belohrad, D; Bravin, E; Calvo, E; Dehning, B; Emery, J; Favier, M; Gras, JJ; Guerrero, A; Jeff, A; Lefevre, T; Rabiller, A; Roncarolo, F; Sapinski, M; Soby, L; Steinhagen, R

    2011-01-01

    This note contains the preliminary results of the LHC MD that took place on 29-June-2011 (from 10 p.m. to 07 a.m.), dedicated to study Beam Current Monitors (BCT), Wire Scaners (WS), Synchrotron Radiation (BSRT), Beam Position (BPM), Wall Current (WCM) and Beam Gas Ionization (BGI) monitors. The MD aimed at performing different studies on the individual monitors. At the same time, it was possible to perform calibration studies with the Abort Gap (AGM) and Longitudinal Density (LDM) monitors that share the extracted light with the BSRT. Additionally some observations about the beam stability and emittance dependence on the chromaticity were performed.

  17. Analysis of the message digest algorithm MD5%报文摘要算法MD5分析

    Institute of Scientific and Technical Information of China (English)

    燕辉; 叶震; 董泽浩; 高柯俊

    2002-01-01

    随着计算机网络的发展,社会对网络安全的要求也越来越紧迫。文章回顾了网络安全的目标、几种网络攻击方法和网络安全技术,重点分析了普遍用在数据签名中的MD5报文摘要算法。首先描述了MD5报文摘要算法,并对其进行了详细分析,找出了它的缺陷,最后推荐了一种为克服此缺陷而对MD5算法进行的改进方法。

  18. Hardware Implementation of HMAC-MD5 Algorithm%HMAC-MD5算法的硬件实现

    Institute of Scientific and Technical Information of China (English)

    吴旭凡; 胡晨; 田渊; 丁黄胜

    2003-01-01

    信息安全体系中的消息验证是一个非常重要的方面.采用以散列函数为基础的消息验证编码是其中的一种重要方法.现提出了硬件实现一种以MD5算法为基础的消息验证编码(HMAC-MD5)的电路结构.该电路结构通过对MD5核心运算模块的复用,缩小了电路规模,达到了较高的处理速度.用VerilogHDL描述电路结构,并且在FPGA上验证了该结构的正确性.

  19. Research and Improvement of MD5 Algorithm%MD5算法的研究与改进

    Institute of Scientific and Technical Information of China (English)

    毛熠; 陈娜

    2012-01-01

    MD5 algorithm has important applications in the field of data encryption such as digital signature, identity authentication and so on, but it can not resist differential attack and dictionary attack. This paper does certain special transform on some related variables during message preprocessing course of MD5 to improve probability of data high overflow, and increase the avalanche effect and difficulty of differential cryptanalysis, so that collision problem of MD5 algorithm is solved. Through doing collision detection, coincidence detection of encrypted values before and after improvement for improved algorithm, the improved MD5 is proved safe and practical.%MD5算法在数字签名、身份认证等数据加密领域有重要的应用,但其无法抵御差分攻击和查字典攻击.为此,通过对算法消息处理过程中涉及的一些变量进行特殊变换,提高运算中数据高位溢出的几率,增强其雪崩效应,增加差分分析的难度,由此解决MD5算法的碰撞问题.对改进的算法进行碰撞检测、加密值重合检测以及改进前后加密值的重合检测,结果证明其具有较高的安全性和实用价值.

  20. Research of MD5 shadow table method based on MD5 algorithm%一种融入MD5的影子表算法研究

    Institute of Scientific and Technical Information of China (English)

    袁满; 康峰峰; 黄刚

    2013-01-01

    As for the rapid extraction of source data, the rapid identification of changing data and the rapid incremental extraction of data, underlying the analysis of the working principle of the traditional shadow table, this paper proposed a kind of improved linear algorithm which merged MD5 algorithm into the ST. It scanned compared tables for the linear and eliminates unnecessary inverse operation. During scanning these tables, it employed MD5 algorithm to calculate the whole record ' fingerprint ' , it reduced the frequency and duration of string matching, and it could quickly recognize the changed records. The algorithm was verified practically, and the result shows that the proposed algorithm can improve the efficiency of data extraction in database. Incremental extraction method based on shadow table is a general incremental capturing method, and it can be implemented in any database. These applications can easily be transplanted in all kinds of platforms, so it is suitable to solve the heterogeneous database replication issues.%为了快速提取源头数据、快速识别变化记录以及实现数据的快速增量提取,在剖析传统影子表法的工作原理上,提出基于MD5算法的影子表法的改进型线性算法,对对比表进行线性扫描,排除了不必要的回扫操作;同时通过MD5算法计算整条记录的“指纹”,降低了字符串比对次数和时间,能够迅速识别出发生变化的记录.对所提出算法进行了应用测试,结果表明通过融入MD5算法后的影子表法提高了数据提取效率.基于影子表的增量提取方法是一种通用的增量捕获方法,能在任何数据库上实现;应用程序可以方便地在多种平台间移植,因此很适合解决异构数据库复制问题.

  1. 76 FR 36447 - Safety Zone; Patuxent River, Patuxent River, MD

    Science.gov (United States)

    2011-06-22

    ..., 2008, issue of the Federal Register (73 FR 3316). Public meeting We do not now plan to hold a public... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Patuxent River, Patuxent River, MD AGENCY... a temporary safety zone during the ``NAS Patuxent River Air Expo '11'', which consists of...

  2. 77 FR 12476 - Drawbridge Operation Regulation; Curtis Creek, Baltimore, MD

    Science.gov (United States)

    2012-03-01

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Curtis Creek, Baltimore..., across Curtis Creek, mile 1.0, at Baltimore, MD. This deviation allows the bridge to operate on...

  3. 75 FR 54069 - Drawbridge Operation Regulations; Curtis Creek, Baltimore, MD

    Science.gov (United States)

    2010-09-03

    ... (75 FR 30747-30750). The rulemaking concerned eliminating the need for a bridge tender by allowing the... SECURITY Coast Guard 33 CFR Part 117 RIN 1625--AA09 Drawbridge Operation Regulations; Curtis Creek... Avenue Bridge, at mile 0.9, across Curtis Creek at Baltimore, MD. The requested change would have...

  4. 76 FR 9225 - Drawbridge Operation Regulation; Curtis Creek, Baltimore, MD

    Science.gov (United States)

    2011-02-17

    ... Regulations; Curtis Creek, Baltimore, MD'' in the Federal Register (74 FR 50707). The temporary deviation... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Curtis Creek, Baltimore... changing the drawbridge operation regulations of the Pennington Avenue Bridge, across Curtis Creek, mile...

  5. 75 FR 1705 - Drawbridge Operation Regulations; Curtis Creek, Baltimore, MD

    Science.gov (United States)

    2010-01-13

    ... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulations; Curtis Creek... operation of the I695 Bridge across Curtis Creek, mile 0.9, at Baltimore, MD. The deviation is necessary to... section of Curtis Creek and the bridge will not be able to open in the event of an emergency. Coast...

  6. 75 FR 50707 - Drawbridge Operation Regulation; Curtis Creek, Baltimore, MD

    Science.gov (United States)

    2010-08-17

    ... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Curtis Creek, Baltimore... operation of the Pennington Avenue Bridge, across Curtis Creek, mile 0.9, at Baltimore, MD. This deviation... vessels bound for the Coast Guard Yard at Curtis Bay, as well as a significant amount of commercial...

  7. 78 FR 3496 - Maryland Disaster Number MD-00025

    Science.gov (United States)

    2013-01-16

    ... ADMINISTRATION Maryland Disaster Number MD-00025 AGENCY: U.S. Small Business Administration. ACTION: Amendment 3... completed loan applications to: U.S. Small Business Administration, Processing and Disbursement Center... Disaster Assistance, U.S. Small Business Administration, 409 3rd Street SW., Suite 6050, Washington,...

  8. 77 FR 74908 - Maryland Disaster Number MD-00025

    Science.gov (United States)

    2012-12-18

    ... ADMINISTRATION Maryland Disaster Number MD-00025 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1... completed loan applications to: U.S. Small Business Administration, Processing and Disbursement Center... Disaster Assistance, U.S. Small Business Administration, 409 3rd Street SW., Suite 6050, Washington,...

  9. 77 FR 73967 - Drawbridge Operation Regulation; Bear Creek, Dundalk, MD

    Science.gov (United States)

    2012-12-12

    ... Regulation; Bear Creek, Dundalk, MD'' in the Federal Register (77 FR 5201). The rulemaking concerned would... proposed rulemaking the bridge owner displayed on the Wise Avenue Bridge signage that stated a 48-hour advance notice was required to open the draw bridge. This signage portrayed improper...

  10. Improved Collision Attack on Hash Function MD5

    Institute of Scientific and Technical Information of China (English)

    Jie Liang; Xue-Jia Lai

    2007-01-01

    In this paper, we present a fast attack algorithm to find two-block collision of hash function MD5.The algorithm is based on the two-block collision differential path of MD5 that was presented by Wang et al.In the Conference EUROCRYPT 2005.We found that the derived conditions for the desired collision differential path were not sufficient to guarantee the path to hold and that some conditions could be modified to enlarge the collision set.By using technique of small range searching and omitting the computing steps to check the characteristics in the attack algorithm, we can speed up the attack of MD5 efficiently.Compared with the Advanced Message Modification technique presented by Wang et al.,the small range searching technique can correct 4 more conditions for the first iteration differential and 3 more conditions for the second iteration differential, thus improving the probability and the complexity to find collisions.The whole attack on the MD5 can be accomplished within 5 hours using a PC with Pentium4 1.70GHz CPU.

  11. 基于MD5的迭代散列算法%Iterative Hashing Algorithm Based on MD5

    Institute of Scientific and Technical Information of China (English)

    张青

    2011-01-01

    The paper analyzes the user name and password storage methods and their risks on the internet. On this basis, it analyzes MD5 message digest encryption weaknesses and deciphering means. In response to these decoding methods, it proposes an iterative algorithm based on MD5. This algorithm is immune to the second birthday attack, meanwhile improve the complicates of the the first birthday attack. It is also useful for rainbow table attack. The algorithm can enhance password security features, thereby enhancing the network information transmission and storage security.%分析网络中用户名、密码的存储方式及其存在的风险.在此基础上分析MD5散列算法的弱点及其破译手段.针对这些破泽方法提出基于MD5的迭代散列算法.该算法可以避免第二类生日攻击,并有效提高第一类生日攻击的复杂度,对于破解效率最高的彩虹表也具有免疫性,能够加强密码的安全性能,从而提高网络中信息传递和存储的安全性.

  12. A Fast Attack Algorithm on the MD5 Hash Function

    Institute of Scientific and Technical Information of China (English)

    WANG Zhang-yi; ZHANG Huan-guo; QIN Zhong-ping; MENG Qing-shu

    2006-01-01

    The sufficient conditions for keeping desired differential path of MD5 was discussed. By analyzing the expanding of subtraction difference, differential characters of Boolean functions, and the differential characters of shift rotation, the sufficient conditions for keeping desired differential path could be obtained. From the differential characters of shift rotation, the lacked sufficient conditions were found. Then an algorithm that reduces the number of trials for finding collisions were presented. By restricting search space, search operation can be reduced tc 234 for the first block and 230 for the second block. The whole attack on the MD5 can be accomplished within 2C hours using a PC with 1.6 G CPU.

  13. MD210 Note: Creation of Hollow Bunches in the PSB

    CERN Document Server

    Oeftiger, Adrian; Findlay, Alan James; Hancock, Steven; Rumolo, Giovanni; CERN. Geneva. ATS Department

    2016-01-01

    MD210 aims for the creation of longitudinally hollow bunches in the CERN PS Booster. The first three sessions have been carried out using the radial loop feedback system in order to drive the beam on a dipolar parametric resonance (instead of the phase loop). It has been found that the damping by the phase loop inhibits the excitation of the resonance to a major extent. The hollow distributions generated under these circumstances fail to reach a satisfying bunching factor. Nonetheless, proving the principally successful application of this technique to the PS Booster promises good results once the phase loop system supports trim functions. The approach, actions and detailed results of the first three MD sessions are presented in this paper.

  14. MD 382: Beam Transfer Function and diffusion mechanisms

    CERN Document Server

    Tambasco, Claudia; Buffat, Xavier; Crouch, Matthew; Pieloni, Tatiana; Boccardi, Andrea; Fuchsberger, Kajetan; Gasior, Marek; Kotzian, Gerd; Lefevre, Thibaut; Pojer, Mirko; Salvachua Ferrando, Belen Maria; Solfaroli Camillocci, Matteo; Giachino, Rossano; CERN. Geneva. ATS Department

    2016-01-01

    The Beam Transfer Function (BTF) measurements have been previously tested in the LHC during MD block 1 and 2. Different machine configurations (i.e. energy, beam intensity, emittance etc...) have been tested to determine a safe set-up (excitation amplitude) of the system to be completely transparent to the beam (no emittance blow-up neither losses). The aim of this experiment in MD block 3 was to characterize the Stability Diagram (SD) in the presence of diffusion mechanisms induced by excited resonances due to beam-beam long range and Landau octupole interplay. During the experiment, BTF measurements have been acquired at flat top for different settings of Landau octupole current, different chromaticity values and transverse feedback gains. In this note the description of the experiment is presented together with some preliminary results.

  15. Analytical applications of MD-FIA-optical detection systems

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    A brief introduction of recent research works in our laboratory concerning microdialysis(MD) based on optical detection combined with FIA is made in this mini-review. A biosensor system has been designed and realized the real time in vivo monitoring of some important clinic substances such as calcium, uric acid. The system has also been used to study the in vitro binding of drug-protein.

  16. A Secure Hash Function MD-192 With Modified Message Expansion

    OpenAIRE

    Harshvardhan Tiwari; Dr. Krishna Asawa

    2010-01-01

    Cryptographic hash functions play a central role in cryptography. Hash functions were introduced in cryptology to provide message integrity and authentication. MD5, SHA1 and RIPEMD are among the most commonly used message digest algorithm. Recently proposed attacks on well known and widely used hash functions motivate a design of new stronger hash function. In this paper a new approach is presented that produces 192 bit message digest and uses a modified message expansion mechanism which gene...

  17. MD 346: Summary of single bunch instability threshold measurements

    CERN Document Server

    Carver, Lee Robert; Metral, Elias; Salvant, Benoit; Levens, Tom; Buffat, Xavier; Pieloni, Tatiana; Tambasco, Claudia; Trad, Georges; CERN. Geneva. ATS Department

    2016-01-01

    The purpose of this MD is to measure the octupole current threshold to reach single-bunch stability in the LHC at flat top. Two bunches with dierent emittances are injected in the LHC in both B1 and B2 and the current in the Landau octupoles was progressively decreased until an instability developed. The measurements provide insight into the LHC impedance model by comparing them with the stabilizing octupole current predicted from DELPHI.

  18. Application of MD Simulations to Predict Membrane Properties of MOFs

    OpenAIRE

    Elda Adatoz; Seda Keskin

    2015-01-01

    Research Article Application of MD Simulations to Predict Membrane Properties of MOFs Elda Adatoz and Seda Keskin Chemical and Biological Engineering, Koc University, Rumelifeneri Yolu, Sariyer, 34450 Istanbul, Turkey Correspondence should be addressed to Seda Keskin; Received 22 May 2015; Accepted 13 July 2015 Academic Editor: Yanlin Song Copyright © 2015 E. Adatoz and S. Keskin. This is an open access article distributed under the Creative Commons A...

  19. MD 349: Impedance Localization with AC-dipole

    CERN Document Server

    Biancacci, Nicolo; Metral, Elias; Salvant, Benoit; Papotti, Giulia; Persson, Tobias Hakan Bjorn; Tomas Garcia, Rogelio; CERN. Geneva. ATS Department

    2016-01-01

    The purpose of this MD is to measure the distribution of the transverse impedance of the LHC by observing the phase advance variation with intensity between the machine BPMs. Four injected bunches with different intensities are excited with an AC dipole and the turn by turn data is acquired from the BPM system. Through post-processing analysis the phase variation along the machine is depicted and, from this information, first conclusions of the impedance distribution can be drawn.

  20. MD 754: Instability Threshold for Train with 25ns Spacing

    CERN Document Server

    Carver, Lee Robert; Biancacci, Nicolo; Iadarola, Giovanni; Levens, Tom; Metral, Elias; Salvant, Benoit; Wang, Na; CERN. Geneva. ATS Department

    2016-01-01

    Measurements made since the beginning of run II at 6.5 TeV have shown that there is a large discrepancy in the instability thresholds between single bunches and trains of 72 bunches with 25ns spacing, whereas the same result is expect for pure impedance-induced instabilities. One possible explanation is that the presence of electron cloud is affecting the beam stability. This MD will attempt to determine if electron cloud is the dominant mechanism affecting beam stability.

  1. Implementation of MD5 Fast Decryption Algorithm Based on Graphic Processing Unit%基于GPU的MD5高速解密算法的实现

    Institute of Scientific and Technical Information of China (English)

    乐德广; 常晋义; 刘祥南; 郭东辉

    2010-01-01

    MD5快速碰撞算法由于不支持逆向过程而无法在MD5密码攻击中得到实际应用.针对上述问题,通过分析基于图形处理单元(GPU)的MD5密码并行攻击算法原理,设计基于GPU的MD5高速解密算法,在此基础上实现一个MD5高速密码攻击系统.测试结果证明,该算法能有效加快MD5密码破解速度.

  2. 77 FR 7182 - Scott W. Houghton, M.D.; Decision and Order

    Science.gov (United States)

    2012-02-10

    ... practitioner who lacks .'' Roy Chi Lung, 74 FR 20346, 20347 (2009); Scott Sandarg, D.M.D., 74 FR 17528, 174529 (2009); John B. Freitas, D.O., 74 FR 17524, 17525 (2009); Roger A. Rodriguez, M.D., 70 FR 33206, 33207 (2005); Stephen J. Graham, M.D., 69 FR 11661 (2004); Dominick A. Ricci, M.D., 58 FR 51104...

  3. The Application Research of MD5 Encryption Algorithm in DCT Digital Watermarking

    Science.gov (United States)

    Xijin, Wang; Linxiu, Fan

    This article did the preliminary study of the application of algorithm for MD5 in the digital watermark. It proposed that copyright information will be encrypted using an algorithm MD5, and made rules for the second value image watermarks, through DCT algorithm that embeds an image by the carrier. The extraction algorithms can pick up the watermark and restore MD5 code.

  4. 76 FR 71369 - Robert G. Crummie, M.D.; Decision and Order

    Science.gov (United States)

    2011-11-17

    ... intend administrative agencies to perform meaningless tasks. See Layfe Robert Anthony, M.D., 67 FR 35582... authority under the laws of the state in which he does business. See Scott Sandarg, D.M.D., 74 FR 17528 (DEA 2009); David W. Wang, M.D., 72 FR 54297 (DEA 2007); Sheran Arden Yeates, M.D., 71 FR 39130 (DEA...

  5. 76 FR 45867 - Michael S. Moore, M.D.; Suspension of Registration

    Science.gov (United States)

    2011-08-01

    ....S.A. 823 and 824. \\8\\ Indeed, in Alan H. Olefsky, 57 FR 928 (1992), DEA revoked a practitioner's... purposes of the CSA. Edson W. Redard, M.D., 65 FR 30616, 30618 (2000); Stanley Alan Azen, M.D., 61 FR 57893... (1997)); Redard, 65 FR at 30618; Stanley Alan Azen, M.D., 61 FR 57893, 57895 (1996). Agency...

  6. Application of MD5 Algorithm in Database System%MD5算法在数据库系统中的应用

    Institute of Scientific and Technical Information of China (English)

    罗金涛

    2013-01-01

    数据加密是保护数据安全的重要手段,MD5是目前信息安全领域中使用比较广泛的加密算法,对MD5算法的原理进行了分析,并将MD5算法应用在数据库的登录验证过程中.

  7. The Class of 1989 and post-MD training

    Science.gov (United States)

    Ryten, E; Thurber, A D; Buske, L

    1998-01-01

    BACKGROUND: "The Class of 1989" is a longitudinal study of 1722 people who were awarded an MD degree by a Canadian university in 1989. This paper reports on the details of their post-MD training up to spring 1996. METHODS: Several medical professional and educational associations in Canada and the United States provided year-by-year information on field and location of post-MD training, certification achieved, whether in practice and location of practice through to spring 1996. Information from all sources was linked to a list of 1989 medical school graduates. RESULTS: Of the 1722 graduates 57 (3.3%) never entered post-MD training in Canada; 147 (8.5%) did 1 or more years of training in the United States. A total of 222 graduates (12.9%) took a break of at least 1 year from training, and 301 (17.5%) changed their choice of field or specialty after starting training. Substantial numbers took 1 or more years longer to complete training than would be expected based on the prescribed length of the training program chosen. The field or specialty choices of the cohort produced a generalist:specialist ratio of 58:42. The final numbers in several fields depended heavily on trainees changing their initial career choice. INTERPRETATION: The data point out widely differing and often very long lead times from start to completion of training. Since 1993, changes to licensure requirements have reduced opportunities for recent graduating cohorts to delay final career choices, take a break in training, prolong training or change initial career choices. Rigidities in the post-1993 training environment point to the emergence of a number of serious problems, such as dissatisfaction and high anxiety levels among residents, licensing authorities being faced with people who have not completed a training program to certification, and insufficient provision of positions for post-MD training because of underestimates of the time needed to complete training programs. The insights gained

  8. MD5算法在用户口令认证中的应用%The Application of MD5 Algorithm in The User Password Authentication

    Institute of Scientific and Technical Information of China (English)

    刘洪民; 印帮辉

    2014-01-01

    MD5算法是目前比较安全且易用的加密算法,其在密码领域有着举足轻重的地位.本文通过介绍MD5算法的特点及加密原理,分析了MD5算法在用户口令认证中的安全隐患,给出了用户口令认证应用中如何提高MD5算法安全性的措施和方法.

  9. Application of MD5 Encryption Algorithm Based on C# Technology%基于C#技术的MD5加密算法的应用

    Institute of Scientific and Technical Information of China (English)

    王倩丽

    2010-01-01

    在对Message-Digest Algorithm 5进行简要描述的同时,对MD5算法的原理作深入分析.运用MD5算法,采用目前流行的C#语言进行了具体研究,设计了MD5加密演示系统,经过测试该系统可以准确实现数据的MD5加密.

  10. SECURITY ANALYSIS ON MD5 AND ITS APPLICATION%MD5安全性分析及其应用

    Institute of Scientific and Technical Information of China (English)

    谭剑鸣; 徐建华; 汪崇华

    2002-01-01

    本文详细论述了MD5报文分解函数对文件签名的工作原理,剖析了MD5的安全性,针对具体的应用提出了使用MD5与RSA结合来解决数字签名的完整方案.文章的最后对MD5在PGP数字签名中的具体应用进行了分析讨论.

  11. Design and Implementation of MD5 with Salt%一种带随机数MD5算法的设计与实现

    Institute of Scientific and Technical Information of China (English)

    张丽香

    2013-01-01

    随着网络的迅速普及,信息加密技术的发展对保障网络安全有着重大的作用与意义.MD5是HASH算法,常用来对重要数据的进行存储,本文对MD5算法进行了简要描述,介绍了MD5的破解方式,并对带随机数MD5算法进行了描述,采用PHP对算法的使用进行实现.

  12. Nano-scratch study of molecular deposition (MD) films on silicon wafer using nanoindentation~1

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Experiment of the molecular deposition (MD) films with and without alkyl terminal de-posited on the silicon wafer were conducted by using nanoindentation. It was found that MD filmsand alkyl terminated MD films exhibit higher critical load (scratch resistance or adhesive strength)and lower coefficient of friction compared with the silicon substrate. Critical load (scratch resis-tance) increases with the number of layers, and coefficients of friction of those MD film with alkylterminal are still best for the same layer of MD film.

  13. 改进MD5码增强网站密码安全性

    Institute of Scientific and Technical Information of China (English)

    张越; 陈跃; 刘林飞

    2009-01-01

    目的探讨改进MD5码,增强网络安全性.方法采用对用户密码进行加长、加强的二次加密,并对MD5码的算法进行修改,再使用MD5二次加密或多次加密.结果通过改进MD5码,用户密码安全性明显增强.结论改进MD5码,可以提高网站安全性.

  14. A Secure Hash Function MD-192 With Modified Message Expansion

    CERN Document Server

    Tiwari, Harshvardhan

    2010-01-01

    Cryptographic hash functions play a central role in cryptography. Hash functions were introduced in cryptology to provide message integrity and authentication. MD5, SHA1 and RIPEMD are among the most commonly used message digest algorithm. Recently proposed attacks on well known and widely used hash functions motivate a design of new stronger hash function. In this paper a new approach is presented that produces 192 bit message digest and uses a modified message expansion mechanism which generates more bit difference in each working variable to make the algorithm more secure. This hash function is collision resistant and assures a good compression and preimage resistance.

  15. A Secure Hash Function MD-192 With Modified Message Expansion

    Directory of Open Access Journals (Sweden)

    Harshvardhan Tiwari

    2010-02-01

    Full Text Available Cryptographic hash functions play a central role in cryptography. Hash functions were introduced in cryptology to provide message integrity and authentication. MD5, SHA1 and RIPEMD are among the most commonly used message digest algorithm. Recently proposed attacks on well known and widely used hash functions motivate a design of new stronger hash function. In this paper a new approach is presented that produces 192 bit message digest and uses a modified message expansion mechanism which generates more bit difference in each working variable to make the algorithm more secure. This hash function is collision resistant and assures a good compression and preimage resistance.

  16. StandsSIM-MD: a Management Driven forest SIMulator

    Directory of Open Access Journals (Sweden)

    Susana Barreiro

    2016-07-01

    Full Text Available Aim of the study: The existing stand level forest simulators available in Portugal were not developed with the aim of including up-to-date model versions and were limited in terms of accounting for forest management. The simulators’ platform, sIMfLOR was recently created to implement different growth models with a common philosophy. The objective was developing one easily-updatable, user-friendly, forest management and climate change sensitive simulator capable of projecting growth for the main tree species in Portugal. Area of the study: Portugal. Material and methods: The new simulator was programmed in a modular form consisting of several modules. The growth module integrates different forest growth and yield models (empirical and process-based for the main wood production tree species in Portugal (eucalypt, umbrella and maritime pines; whereas the management module drives the growth projections along the planning horizon according to a range of forest management approaches and climate (at present only available for eucalypt. Main results: The main result is the StandsSIM-MD Management Driven simulator that overcomes the limitations of the existing stand level simulators. It is a step forward when compared to the models currently available in the sIMfLOR platform covering more tree species, stand structures and stand compositions. It is focused on end-users and it is based on similar concepts regarding the generation of required inputs and generated outputs. Research highlights: -          Forest Management Driven simulations approach -          Multiple Prescriptions-Per-Stand functionality -          StandsSIM-MD can be used to support landowners decisions on stand forest management -          StandsSIM-MD simulations at regional level can be combined with optimization routines Keywords: Forest simulator, Forest Management Approaches; StandsSIM-MD; forest management.

  17. 散列算法MD5和SHA-1的比较%Comparison between MD5 and SHA-1

    Institute of Scientific and Technical Information of China (English)

    王泽; 曹莉莎

    2016-01-01

    MD5 and SHA-1 are the two known Hash Algorithm which are widely applied in information security, they are both developed from MD4.This paper introduces their algorithm logic in detail, compares them though simulation experiment ,soft-ware testing, etc. Finally, it draw a conclusion:The SHA-1 algorithm is more secure than the MD5 algorithm, but in the same hardware, SHA-1 is slower than MD5.%MD5和SHA-1是两个已知的广泛应用于信息安全的散列算法,均由MD4发展而来。详细介绍了它们的算法逻辑,并通过模拟实验、软件测试等方式对其在各个方面进行比较,最终得出结论:SHA-1算法比MD5算法的安全性更高,但在同一硬件上,SHA-1比MD5运行的要慢。

  18. Reverse Crack of MD5 Encryption and Its Safety Improvement%MD5加密逆向破解及安全性改进

    Institute of Scientific and Technical Information of China (English)

    王雄; 朱志祥; 许辉辉

    2014-01-01

    针对消息摘要算法第五版(Message-Digest Algorithm 5,MD5)不可逆的特性,通过组建Oracle明文数据库、调用MD5函数,建立明文与MD5码之间的一一对应关系,实现了对MD5加密的逆向破解.从应对碰撞攻击和反向查询两方面,总结多种改进措施,提高了MD5加密算法在实际应用中的安全性.

  19. MD5加密算法的研究及应用%Research and application of MD5 encryption algorithm

    Institute of Scientific and Technical Information of China (English)

    魏晓玲

    2010-01-01

    针对当前网站建设和系统开发中用户信息等重要数据的安全问题,提出了一种MD5加密算法,可以对用户密码进行加密.MD5加密算法是一种比较常用的单向加密算法,通过对该算法的深入研究,介绍了MD5算法的特性、算法原理及其算法流程,并给出MD5算法在一个具体系统中的实际应用,得出MD5算法是一种非常安全和易用的加密算法.

  20. [Professor Frantisek Por MD and Professor Robert Klopstock MD, students at Budapest and Prague Faculties of Medicine].

    Science.gov (United States)

    Mydlík, M; Derzsiová, K

    2010-11-01

    Professor Frantisek Por MD and Professor Robert Klopstock MD were contemporaries, both born in 1899, one in Zvolen, the other in Dombovar, at the time of Austro-Hungarian Monarchy. Prof. Por attended the Faculty of Medicine in Budapest from 1918 to 1920, and Prof. Klopstock studied at the same place between 1917 and 1919. From 1920 until graduation on 6th February 1926, Prof. Por continued his studies at the German Faculty of Medicine, Charles University in Prague. Prof. Klopstock had to interrupt his studies in Budapest due to pulmonary tuberculosis; he received treatment at Tatranske Matliare where he befriended Franz Kafka. Later, upon Kafka's encouragement, he changed institutions and continued his studies at the German Faculty of Medicine, Charles University in Prague, where he graduated the first great go. It is very likely that, during their studies in Budapest and Prague, both professors met repeatedly, even though their life paths later separated. Following his graduation, Prof. Por practiced as an internist in Prague, later in Slovakia, and from 1945 in Kosice. In 1961, he was awarded the title of university professor of internal medicine at the Faculty of Medicine, Pavol Jozef Safarik University in Kosice, where he practiced until his death in 1980. Prof. Klopstock continued his studies in Kiel and Berlin. After his graduation in 1933, he practiced in Berlin as a surgeon and in 1938 left for USA. In 1962, he was awarded the title of university professor of pulmonary surgery in NewYork, where he died in 1972.

  1. 基于简化MD5的TFIDF算法%TFIDF Algorithm Based on a Simplified MD5

    Institute of Scientific and Technical Information of China (English)

    刘雅正; 陈受凯; 唐向阳

    2012-01-01

    随着信息技术不断的发展,海量数据的处理效率成为不可逃避的问题.传统的网页分类算法在分类效果上已经相对成熟,所以在这样的背景下从传统网页分类算法中特征值权重算法的效率和代价出发,分析并提出了基于简化MD5的特征值权重算法.有效减少了特征值提取时的比对和最后一次排序的效率,从而提高了整个网页分类的效率.%With the rapid development of information technology, the process efficiency of massive data has become inescapable problem and Web page classification algorithm has matured yet, so from the efficiency and cost of eigenvalue weights algorithm in traditional web page classification algorithm is started. Eigenvalue weights algorithm based on a simplified MD5, and effective in reducing the efficiency of eigenvalue extraction time and the last sort of eigenvalue are analyzed and proposed. Improving the efficiency of the whole Web page classification is presented.

  2. The improvement of cryptography MD5 algorithm%密码学中信息摘要算法MD5的改进

    Institute of Scientific and Technical Information of China (English)

    林平

    2011-01-01

    MD5算法的基础上,针对MD5算法密文是一个32位16进制字符来表示值的特征,提出MD5改进算法,首先采用替换加密算法Md5Replace加密MD5算法密文,隐藏MD5算法密文的特征;再选定替换加密密文中某一位置插入由随机函数算法Md5Random产生定长的字符串得到最后的密文,改变了替换加密密文位数,隐藏了替换加密算法替换规律.在不改变算法效率的前提下,提高算法安全强度.

  3. MD5碰撞攻击的差分路径构建%Constructing Differential Path in MD5 Collision Attack

    Institute of Scientific and Technical Information of China (English)

    刘凡保; 谢涛

    2009-01-01

    著名的杂凑算法MD5是MD4的增强版本,由Ronald L.Rivest在1991年设计.MD5广泛应用于口令变换、数据完整性、数字证书等领域.近年最具影响的MD5安全性的分析结果是王小云首次发现的MD5碰撞.之后,MD5碰撞攻击的改进主要集中在提高碰撞对搜索的性能.基于新的不同于王小云的明文差分构成的MD5碰撞,介绍差分路径的构建方法,并给出一条差分路径以及碰撞对数据.

  4. 报文摘要算法MD5的分析与改进

    Institute of Scientific and Technical Information of China (English)

    汪勋亮; 赵春霞; 郭剑辉

    2014-01-01

    MD5算法在数据加密方面有着广泛的应用,但是它无法抵御查字典攻击和差分等攻击。为此本文介绍了报文算法MD5和Base64算法,以及在两种算法的基础上提出了MD5的改进算法,以应对以上被攻击的缺陷。%MD5 encryption algorithm in the data has a wide range of applications,but it can not resist dictionary attacks and differential attacks.This paper introduces the MD5 message digest algorithm and Base64 algorithm,and two algorithms based on the proposed the improved MD5 algorithm,the effect is to deal with the above attack.

  5. WEB登录系统中MD5加密算法的PHP实现%PHP Implementation of MD5 Encryption Algorithm in WEB Login System

    Institute of Scientific and Technical Information of China (English)

    王雄; 李旭辉; 许琳华

    2011-01-01

    MD5是web应用程序中常用的加密算法,很多网站的登录模块都采用了MD5加密,用户登录密码通过使用它加密存储到数据库当中,在一定程度上使入侵者不易获得用户登录权限.本文分析比较了中MD5不同的改进算法,并给出了最后的结论.

  6. The MD5 Technical Analysis and Improvement Measures%MD5技术解析及改进措施

    Institute of Scientific and Technical Information of China (English)

    窦立莉

    2010-01-01

    随着网络的迅速普及,信息加密技术的发展对保障网络安全有着重大的作用与意义.本文对MD5 这种单向加密算法进行了简要描述,对MD5 算法的原理进行了深入分析,并提出了MD5 码的多种改进措施.

  7. Fred Loe, MD, and the history of trachoma.

    Science.gov (United States)

    Feibel, Robert M

    2011-04-01

    Trachoma has been one of the most blinding diseases in the history of ophthalmology. From its initial description in antiquity until the late 1930s, no specific treatment or effective cure had been known, and the only expedient had been to destroy the diseased tissue containing the infectious agent, rendering the disease inactive. Virtually all medical, mechanical, and surgical treatments were unsatisfactory, with cure rates of approximately 20%. Therapy for trachoma had barely advanced from the measures used by the ancient Egyptian, Greek, and Roman physicians. All prior therapies became obsolete in 1938 when Fred Loe, MD, working on an American Indian reservation, introduced sulfanilamide as a treatment of trachoma, achieving a 90% cure rate. One of the most unusual aspects of Loe's career was that he had no formal training in ophthalmology and was completely self-taught as an ophthalmologist. PMID:21482877

  8. A workshop on leadership for MD/PhD students

    Directory of Open Access Journals (Sweden)

    Mark D. Cannon

    2011-08-01

    Full Text Available Success in academic medicine requires scientific and clinical aptitude and the ability to lead a team effectively. Although combined MD/PhD training programs invest considerably in the former, they often do not provide structured educational opportunities in leadership, especially as applied to investigative medicine. To fill a critical knowledge gap in physician-scientist training, the Vanderbilt Medical Scientist Training Program (MSTP developed a biennial two-day workshop in investigative leadership. MSTP students worked in partnership with content experts to develop a case-based curriculum and deliver the material. In its initial three offerings in 2006, 2008, and 2010, the workshop was judged by MSTP student attendees to be highly effective. The Vanderbilt MSTP Leadership Workshop offers a blueprint for collaborative student-faculty interactions in curriculum design and a new educational modality for physician-scientist training.

  9. Luminosity Anti-leveling with Crossing Angle (MD 1669)

    CERN Document Server

    Gorzawski, Arkadiusz; Ponce, Laurette; Salvachua Ferrando, Belen Maria; Wenninger, Jorg; CERN. Geneva. ATS Department

    2016-01-01

    A significant fraction of the LHC luminosity ($\\sim$30\\% in 2016) is lost due to the presence (and necessity) of the crossing angles at the IPs. At the LHC the crossing angle is typically set to a value that provides sufficient separation of the beams at the start of fills for the peak bunch intensities. As the bunch intensity decays during a fill, it is possible to reduce the crossing angle and recover some luminosity. A smooth crossing angle reduction procedure must be developed to take advantage of this option during stable beam operation. During this MD a smooth procedure for luminosity leveling with crossing angle was tested. It was demonstrated that the orbit was well controlled, beam losses were low and the offset leveled experiments ALICE and LHCb were not affected by crossing angle leveling in ATLAS and CMS.

  10. QM/MM-MD simulations of conjugated polyelectrolytes

    DEFF Research Database (Denmark)

    Sjöqvist, Jonas; Linares, Mathieu; Mikkelsen, Kurt Valentin;

    2014-01-01

    A methodological development is reported for the study of luminescence properties of conjugated polyelectrolytes, encompassing systems in which dihedral rotational barriers are easily overcome at room temperature. The components of the model include (i) a molecular mechanics (MM) force field...... description of the solvent in its electronic ground state as well as the chromophore in its electronic ground and excited states, (ii) a conformational sampling by means of classical molecular dynamics (MD) in the respective electronic states, and (iii) spectral response calculations by means of the quantum....... In fluorescence spectroscopy, the experimental spectrum shows a vibrational progression that is not addressed by theory, but the theoretical band position is in excellent agreement with experiment, with a highly accurate description of the Stokes shift as a result....

  11. RADIATION PRESSURE DETECTION AND DENSITY ESTIMATE FOR 2011 MD

    Energy Technology Data Exchange (ETDEWEB)

    Micheli, Marco; Tholen, David J.; Elliott, Garrett T., E-mail: micheli@ifa.hawaii.edu, E-mail: tholen@ifa.hawaii.edu, E-mail: gte@ifa.hawaii.edu [Institute for Astronomy, University of Hawaii, 2680 Woodlawn Drive, Honolulu, HI 96822 (United States)

    2014-06-10

    We present our astrometric observations of the small near-Earth object 2011 MD (H ∼ 28.0), obtained after its very close fly-by to Earth in 2011 June. Our set of observations extends the observational arc to 73 days, and, together with the published astrometry obtained around the Earth fly-by, allows a direct detection of the effect of radiation pressure on the object, with a confidence of 5σ. The detection can be used to put constraints on the density of the object, pointing to either an unexpectedly low value of ρ=(640±330)kg m{sup −3} (68% confidence interval) if we assume a typical probability distribution for the unknown albedo, or to an unusually high reflectivity of its surface. This result may have important implications both in terms of impact hazard from small objects and in light of a possible retrieval of this target.

  12. Plasticity and Failure in Nanocrystalline BCC Metals via MD Simulation

    Energy Technology Data Exchange (ETDEWEB)

    Rudd, R E

    2010-02-12

    Advances in the ability to generate extremely high pressures in dynamic experiments such as at the National Ignition Facility has motivated the need for special materials optimized for those conditions as well as ways to probe the response of these materials as they are deformed. We need to develop a much deeper understanding of the behavior of materials subjected to high pressure, especially the effect of rate at the extremely high rates encountered in those experiments. Here we use large-scale molecular dynamics (MD) simulations of the high-rate deformation of nanocrystalline tantalum at pressures less than 100 GPa to investigate the processes associated with plastic deformation for strains up to 100%. We focus on 3D polycrystalline systems with typical grain sizes of 10-20 nm. We also study a rapidly quenched liquid (amorphous solid) tantalum. We apply a constant volume (isochoric), constant temperature (isothermal) shear deformation over a range of strain rates, and compute the resulting stress-strain curves to large strains for both uniaxial and biaxial compression. We study the rate dependence and identify plastic deformation mechanisms. The identification of the mechanisms is facilitated through a novel technique that computes the local grain orientation, returning it as a quaternion for each atom. This analysis technique is robust and fast, and has been used to compute the orientations on the fly during our parallel MD simulations on supercomputers. We find both dislocation and twinning processes are important, and they interact in the weak strain hardening in these extremely fine-grained microstructures. We also present some results on void growth in nanocrystalline BCC metals under tension.

  13. MD-2 determinants of nickel and cobalt-mediated activation of human TLR4.

    Directory of Open Access Journals (Sweden)

    Alja Oblak

    Full Text Available Recent findings unexpectedly revealed that human TLR4 can be directly activated by nickel ions. This activation is due to the coordination of nickel by a cluster of histidine residues on the ectodomain of human TLR4, which is absent in most other species. We aimed to elucidate the role of MD-2 in the molecular mechanism of TLR4/MD-2 activation by nickel, as nickel binding site on TLR4 is remote from MD-2, which directly binds the endotoxin as the main pathological activator of TLR4. We identified MD-2 and TLR4 mutants which abolished TLR4/MD-2 receptor activation by endotoxin but could nevertheless be significantly activated by nickel, which acts in synergy with LPS. Human TLR4/MD-2 was also activated by cobalt ions, while copper and cadmium were toxic in the tested concentration range. Activation of TLR4 by cobalt required MD-2 and was abolished by human TLR4 mutations of histidine residues at positions 456 and 458. We demonstrated that activation of TLR4 by nickel and cobalt ions can trigger both the MyD88-dependent and the -independent pathway. Based on our results we propose that predominantly hydrophobic interactions between MD-2 and TLR4 contribute to the stabilization of the TLR4/MD-2/metal ion complex in a conformation that enables activation.

  14. Iterative redundant encryption based on MD5 algorithm%基于MD5的迭代冗余加密算法

    Institute of Scientific and Technical Information of China (English)

    王津涛; 覃尚毅; 王冬梅

    2007-01-01

    MD5报文摘要算法是一种非常流行的加密方案,是对任意长度的消息提取数字指纹或消息摘要的算法,但是,在计算上难以提供两个具有相同数字指纹的不同消息,并难以由给定的数字指纹推算出相应的消息.基于MD5的迭代冗余加密算法对MD5算法进行了扩展,利用了MD5算法的强大安全性,实现了文件加密、解密和数据完整性保护的功能.

  15. MD5算法的过程分析及其C#实现%Process Analysis of MD5 Algorithm and Its C# realization

    Institute of Scientific and Technical Information of China (English)

    杜昌钰

    2008-01-01

    文章对MD5即"Message-Digest Algorithm 5(报文流行的C#对8D5算法进行了具体的实现,给出了一个具体的C#加密实例.虽然MD5因王小云教授在2004国际密码学会议(Crypto'2004)上发表的论文受到了前所未有的冲击,但MD5在一些非关键领域应用还是相当广泛.最后还提出了一些针对MD5现状的解决对策和建议.

  16. ASP网站用户帐号的MD5加密技术%The Encryption Techniques of MD5 about User Accounts in ASP Web

    Institute of Scientific and Technical Information of China (English)

    田文艳

    2007-01-01

    本文介绍了Asp中的MD5(Message-Digest Algorithm 5)加密技术,分析了它的工作原理及使用过程,并通过具体的使用实例,说明了MD5加密技术在网站开发中的具体实现方法.

  17. Design of MD5 High-Speed Models on FPGA%基于FPGA的MD5高速处理模型设计

    Institute of Scientific and Technical Information of China (English)

    韩津生; 林家骏; 叶建武; 周文锦

    2012-01-01

    In order to improve the performance of MD5 on FPGA, the design concept based on dataflow was proposed. At the design phase, it can assess effectively the specific FPGA, the expected system performance and the specific complex algorithms. Three models of MD5 round were put forward and one of the models was chosen to do experiment. The experimental results indicate that the designed MD5 algorithm could increase efficiently the throughput up to 66. 56 Gbit/s.%为提高MD5的处理速度,提出了基于数据流的设计思想.该思想在设计阶段可以对特定的FPGA、预期的系统性能、复杂的专用算法等进行有效评估.基于该思想,提出了3种不同的MD5节点模型.通过分析,对其中1种模型进行实验,实验验证了基于数据流的设计思想能有效提高MD5的吞吐量,达到66.56 Gbit/s.

  18. 一种使MD5算法产生更强雪崩效应的方法%Generating stronger avalanche effect in MD5 algorithm

    Institute of Scientific and Technical Information of China (English)

    张鑫彦; 闫德勤

    2010-01-01

    通过研究不同的差分分析对MD5算法的攻击后发现,差分分析攻击之所以可以成功,是因为在MD5算法中改变了明文中一些特定位,而这些特定位的改变在许多轮中最多只影响链接变量的几个位,并且这些小的差分能在随后的多轮操作中得到纠正,从而产生了碰撞.这就说明原MD5算法的雪崩效应不能阻止差分分析的攻击,而为了提高MD5算法的安全性,必须提高其雪崩效应的敏感性.分析结果表明,用动态明文变化函数对MD5算法进行修改,能使其产生更敏感的雪崩效应,以此来有效防止差分分析攻击,提高MD5算法的安全性.

  19. A super-high throughput implementation of MD5 algorithm on FPGA%超高吞吐量MD5算法的FPGA实现

    Institute of Scientific and Technical Information of China (English)

    王臣; 袁焱

    2011-01-01

    In this paper, a novel architecture is proposed to increase the performance of MD5 computing in FPGA , which can achieve a super-high throughput. The scheme is based on full-pipeline for MD5 implementation. Moreover, FIFO cache structure is used for data storage and cooperative computing. The results of simulation and implementation show that the scheme can achieve the theoretical upper bound on throughput. And based on the same platform of FPGA, it outperforms the published scheme with best performance in terms of 77% higher throughput.%为了提高MD5算法在FPGA中实现的运算效率,使之达到超高的数据吞吐量,提出了一种新的全流水线架构,用于实现MD5算法.架构中使用了FIFO缓存存储数据,以配合流水线的运算.实验验证其达到了单个MD5运算单元运算吞吐量的理论上限,在相同芯片平台上,超过已发表的MD5运算模块最高吞吐量的77%.

  20. 33 CFR 110.71 - Jacobs Nose Cove, Elk River, Md.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Jacobs Nose Cove, Elk River, Md... ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.71 Jacobs Nose Cove, Elk River, Md. The water area of Jacobs Nose Cove, on the west side of the mouth of Elk River, Maryland, comprising the...

  1. 75 FR 21528 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

    Science.gov (United States)

    2010-04-26

    ... Policies and Procedures (44 FR 11034, February 26, 1979), and 3. Will not have a significant economic... have the same design as those installed on Model MD-90-30 airplanes. Therefore, Model MD-90-30..., hangar lighting, flashlight, or ] droplight and may require removal or opening of access panels or...

  2. 75 FR 49979 - Tony T. Bui, M.D.; Revocation of Registration

    Science.gov (United States)

    2010-08-16

    ....'' Robert A. Leslie, M.D., 68 FR 15227, 15230 (2003). I ``may rely on any one or a combination of factors... produced a letter from Vella V. Chancellor, M.D., the Chair of the Physician's Recovery Committee of the Dallas County Medical Society. RX 11. Dr. Chancellor wrote that Respondent ``has been actively seeing...

  3. 77 FR 67673 - Fernando Valle, M.D.; Decision and Order

    Science.gov (United States)

    2012-11-13

    ... DEA registration. Serenity Caf , 77 FR 35027, 35028 (2012); David W. Wang, 72 FR 54297, 54298 (2007); Sheran Arden Yeates, 71 FR 39130, 39131 (2006); Dominick A. Ricci, M.D., 58 FR 51104 (1993); Bobby Watts, M.D., 53 FR 11919 (1988). Notwithstanding the foregoing, the Respondent contends that the...

  4. 76 FR 50950 - Drawbridge Operation Regulation; Isle of Wight (Sinepuxent) Bay, Ocean City, MD

    Science.gov (United States)

    2011-08-17

    ... (Sinepuxent) Bay, Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking. SUMMARY: The... of Wight (Sinepuxent) Bay, mile 0.5, at Ocean City, MD. The proposed change will alter the dates the... will then become highlighted in blue. In the ``Document Type'' drop down menu select ``Proposed...

  5. H5MD: a structured, efficient, and portable file format for molecular data

    CERN Document Server

    de Buyl, Pierre; Höfling, Felix

    2013-01-01

    We propose a new open file format named "H5MD" for storing molecular simulation data such as trajectories of particle positions and velocities as well as thermodynamic observables that are tracked during the course of the simulation. H5MD files are HDF5 (Hierarchical Data Format) files with a specific hierarchy and naming scheme. Thus, H5MD inherits many benefits of HDF5, e.g., structured layout of multi-dimensional data sets, data compression, fast and parallel I/O, and portability across many programming languages and hardware platforms. H5MD files are self-contained, and foster the reproducibility of scientific data and the interchange of data between researchers using different simulation programs and analysis software. In addition, the H5MD specification can serve for other kinds of data (e.g. experimental data) and is extensible to supplemental data without breaking the compliance of the file to the specification.

  6. H5MD: A structured, efficient, and portable file format for molecular data

    Science.gov (United States)

    de Buyl, Pierre; Colberg, Peter H.; Höfling, Felix

    2014-06-01

    We propose a new file format named "H5MD" for storing molecular simulation data, such as trajectories of particle positions and velocities, along with thermodynamic observables that are monitored during the course of the simulation. H5MD files are HDF5 (Hierarchical Data Format) files with a specific hierarchy and naming scheme. Thus, H5MD inherits many benefits of HDF5, e.g., structured layout of multi-dimensional datasets, data compression, fast and parallel I/O, and portability across many programming languages and hardware platforms. H5MD files are self-contained, and foster the reproducibility of scientific data and the interchange of data between researchers using different simulation programs and analysis software. In addition, the H5MD specification can serve for other kinds of data (e.g. experimental data) and is extensible to supplemental data, or may be part of an enclosing file structure.

  7. PHP中的MD5加密机制探究

    Institute of Scientific and Technical Information of China (English)

    党长青

    2014-01-01

    MD5广泛用于加密和解密技术上。现阶段,存在两种加密方式,双向加密和单向加密。MD5是在Web应用程序中最常用的密码加密算法。由于MD5是不可逆的,因而经过MD5计算得到后的密文,不能通过逆向算法得到原文。在PHP应用程序中使用MD5加密文本密码的初衷,就是为了防止数据库中保存的密码不幸泄露后被直接获得。

  8. John Call Dalton, Jr., MD: America's first neurophysiologist.

    Science.gov (United States)

    Fine, E J; Manteghi, T; Sobel, S H; Lohr, L A

    2000-09-26

    Before the discoveries of John Call Dalton, Jr., MD (1824-1889), innervation of laryngeal muscles, long-term effects of cerebellar lesions, and consequences of raised intracranial pressure were poorly understood. Dalton discovered that the posterior cricoarytenoid muscles adducted the vocal cords during inspiration. He confirmed Flourens' observations that acute ablation of the cerebellum of pigeons caused loss of coordination. Dalton observed that properly cared for pigeons gradually recovered "coordinating power." Dalton observed that prolonged raised intracranial pressure caused tachycardia and then fatal bradycardia in dogs. Before Dalton published his photographic atlas of the human brain, neuroanatomy atlases were sketched by Europeans and imported into the United States. Dalton's atlas of the human brain contained precise photographs of vertical and horizontal sections that equal modern works. Before Dalton introduced live demonstrations of animals, physiology was taught by recitation of texts only. Dalton was the first American-born professor to teach physiology employing demonstrations of live animals operated on under ether anesthesia. He wrote an essay advocating experimentation on animals as the proper method of acquiring knowledge of function and that humane animal experimentation would ultimately improve the health of man and animals. His eloquent advocacy for humane experimental physiology quelled attacks by contemporaneous antivivisectionists. Dalton was America's first experimental neurophysiologist. PMID:10994009

  9. Studies of the TLR4-associated protein MD-2 using yeast-display and mutational analyses.

    Science.gov (United States)

    Mattis, Daiva M; Chervin, Adam S; Ranoa, Diana R; Kelley, Stacy L; Tapping, Richard I; Kranz, David M

    2015-12-01

    Bacterial lipopolysaccharide (LPS) activates the innate immune system by forming a complex with myeloid differentiation factor 2 (MD-2) and Toll-like receptor 4 (TLR4), which is present on antigen presenting cells. MD-2 plays an essential role in this activation of the innate immune system as a member of the ternary complex, TLR4:MD-2:LPS. With the goal of further understanding the molecular details of the interaction of MD-2 with LPS and TLR4, and possibly toward engineering dominant negative regulators of the MD-2 protein, here we subjected MD-2 to a mutational analysis using yeast display. The approach included generation of site-directed alanine mutants, and ligand-driven selections of MD-2 mutant libraries. Our findings showed that: (1) proline mutations in the F119-K132 loop that binds LPS were strongly selected for enhanced yeast surface stability, (2) there was a preference for positive-charged side chains (R/K) at residue 120 for LPS binding, and negative-charged side chains (D/E) for TLR4 binding, (3) aromatic residues were strongly preferred at F119 and F121 for LPS binding, and (4) an MD-2 mutant (T84N/D101A/S118A/S120D/K122P) exhibited increased binding to TLR4 but decreased binding to LPS. These studies revealed the impact of specific residues and regions of MD-2 on the binding of LPS and TLR4, and they provide a framework for further directed evolution of the MD-2 protein. PMID:26320630

  10. Md1 and Rp105 regulate innate immunity and viral resistance in zebrafish.

    Science.gov (United States)

    Candel, Sergio; Sepulcre, María P; Espín-Palazón, Raquel; Tyrkalska, Sylwia D; de Oliveira, Sofía; Meseguer, José; Mulero, Victoriano

    2015-06-01

    TLR4 was the first TLR family member identified in mammals and is responsible for the activation of the immune response by bacterial LPS. Later, MD1 and RP105 were shown to form complexes that directly interact with the MD2-TLR4 complex, acting as physiological negative regulators of LPS signaling. Despite the general conservation of various TLR families from fish to mammals, several differences can be appreciated, such as the high tolerance of fish to LPS, the absence of the crucial accessory molecules Md2 and Cd14 for Tlr4 signaling in fish, the absence of Tlr4 in some fish species, and the confirmation that LPS does not signal through Tlr4 in zebrafish. The present study has identified the Rp105 and Md1 homologs in zebrafish, confirming (i) Rp105 and Tlr4 evolved from a common ancestor before the divergence between fish and tetrapods and (ii) the presence of Md1 in teleost fish and the lack of Md2, suggesting that the divergence of these accessory molecules occurred in the tetrapod lineage. Biochemical and functional studies indicate that Md1 binds both Rp105 and Tlr4 in zebrafish. Genetic inhibition of zebrafish Md1 and Rp105 reveals that Md1 or Rp105 deficiency impairs the expression of genes encoding pro-inflammatory and antiviral molecules, leading to increased susceptibility to viral infection. These results shed light on the evolutionary history of Md1 and Rp105 and uncover a previously unappreciated function of these molecules in the regulation of innate immunity.

  11. The Design of MD5 Algorithm against Exhaustion Code-breaking and Its Realization%MD5算法防穷举(冲撞)破译的设计及其实现

    Institute of Scientific and Technical Information of China (English)

    廖思周

    2006-01-01

    在对MD5算法做简单介绍的基础上,针对攻击者拥有巨大密码字典、原文/密文对照数据库,设计了MD5变换算法,是对现有的MD5算法的延伸,大大提高了现成MD5密文的安全性.

  12. MD5算法及在用户口令加密应用中的改进%The Improved MD5 Algorithm in the Encryption of User Passwords

    Institute of Scientific and Technical Information of China (English)

    高洪波; 马素萍

    2010-01-01

    MD5是一种非常优秀的加密算法,曾被大量公司和个人广泛使用.但随着科学技术的发展,MD5牢不可破的神话逐渐破灭.基于此,在分析MD5加密算法及其弱点的前提下,探讨了MD5的改进算法.

  13. 基于MD5的可逆无冗余加密算法%The Reversible Non-Redundant Encryption Algorithm Based on MD5 Algorithm

    Institute of Scientific and Technical Information of China (English)

    陈钧; 刘爱华

    2012-01-01

    If MD5 algorithm is directly used to encrypt sensitive data in database, the data is unable to be deerypted by this algorithm itself, even legitimate users query or update some data for the purpose of restoring data. The database becomes more redundant because secret keys need to be saved for reversible encryption algorithms. This paper proposes a reversible non-redundant encryption algorithm based on MD5 algorithm, which can be ~ to used encrypt and decrypt sensitive data in the database regardless of saving secret keys.%直接采用MD5算法对数据库中的敏感数据加密时,合法用户进行查询、更新等操作需要还原数据,MD5算法无法解密数据.可逆的加密算法都需要保存密钥,数据库增加了数据的冗余.本文提出一种基于MD5算法的可逆无冗余算法,实现对数据库中敏感数据进行加密、解密,而且不需要保存密钥.

  14. Electroporation of archaeal lipid membranes using MD simulations.

    Science.gov (United States)

    Polak, Andraž; Tarek, Mounir; Tomšič, Matija; Valant, Janez; Ulrih, Nataša Poklar; Jamnik, Andrej; Kramar, Peter; Miklavčič, Damijan

    2014-12-01

    Molecular dynamics (MD) simulations were used to investigate the electroporation of archaeal lipid bilayers when subjected to high transmembrane voltages induced by a charge imbalance, mimicking therefore millisecond electric pulse experiments. The structural characteristics of the bilayer, a 9:91 mol% 2,3-di-O-sesterterpanyl-sn-glicerol-1-phospho-myo-inositol (AI) and 2,3-di-O-sesterterpanyl-sn-glicerol-1-phospho-1'(2'-O-α-D-glucosyl)-myo-inositol (AGI) were compared to small angle X-ray scattering data. A rather good agreement of the electron density profiles at temperatures of 298 and 343 K was found assessing therefore the validity of the protocols and force fields used in simulations. Compared to dipalmitoyl-phosphatidylcholine (DPPC), the electroporation threshold for the bilayer was found to increase from ~2 V to 4.3 V at 323 K, and to 5.2 V at 298 K. Comparing the electroporation thresholds of the archaeal lipids to those of simple diphytanoyl-phosphatidylcholine (DPhPC) bilayers (2.5 V at 323 K) allowed one to trace back the stability of the membranes to the structure of their lipid head groups. Addition of DPPC in amounts of 50 mol% to the archaeal lipid bilayers decreases their stability and lowers the electroporation thresholds to 3.8 V and 4.1 V at respectively 323 and 298 K. The present study therefore shows how membrane compositions can be selected to cover a wide range of responses to electric stimuli. This provides new routes for the design of liposomes that can be efficiently used as drug delivery carriers, as the selection of their composition allows one to tune in their electroporation threshold for subsequent release of their load.

  15. Characterization of an Autophagy-related Gene MdATG8i from apple

    Directory of Open Access Journals (Sweden)

    Ping eWang

    2016-05-01

    Full Text Available Nutrient deficiencies restrict apple (Malus sp. tree growth and productivity in Northwest China. The process of autophagy, a conserved degradation pathway in eukaryotic cells, has important roles in nutrient-recycling and helps improve plant performance during periods of nutrient-starvation. Little is known about the functioning of autophagy-related genes (ATGs in apple. In this study, one of the ATG8 gene family members MdATG8i was isolated from M. domestica. MdATG8i has conserved putative tubulin binding sites and ATG7 interaction domains. A 1865-bp promoter region cloned from apple genome DNA was predicated to have cis-regulatory elements responsive to light, environmental stresses and hormones. MdATG8i transcriptions were induced in response to leaf senescence, nitrogen depletion, and oxidative stress. At cellular level, MdATG8i protein was expressed in the nucleus and cytoplasm of onion epidermal cells. Yeast two-hybrid tests showed that MdATG8i could interact with MdATG7a and MdATG7b. In Arabidopsis, its heterologous expression was associated with enhanced vegetative growth, leaf senescence, and tolerance to nitrogen- and carbon-starvation. MdATG8i-overexpressing ‘Orin’ apple callus lines also displayed improved tolerance to nutrient-limited conditions. Our results demonstrate that MdATG8i protein could function in autophagy in a conserved way, as a positive regulator in the response to nutrient-starvation.

  16. Classification of 5-Dimensional MD-Algebras Having Non-Commutative Derived Ideals

    CERN Document Server

    Vu, Le Anh; Nghia, Tran Thi Hieu

    2011-01-01

    The paper presents a subclass of the class of MD5-algebras and MD5-groups, i.e. five dimensional solvable Lie algebras and Lie groups such that their orbits in the co-adjoint representation (K-orbits) are orbits of zero or maximal dimension. The main result of the paper is the classification up to an isomorphism of all MD5-algebras with the non-commutative derived ideal. With this result, we have the complete classification of 5-dimensional solvable Lie algebras.

  17. MD5算法应用失败的思考

    Institute of Scientific and Technical Information of China (English)

    TC-XB

    2007-01-01

    MD5算法作为一种高强度的加密算法,被广泛的应用于软件的注册算法中。但是需要指明的是.尽管MD5本身非常强大.但是如果应用不当,那么对软件的保护效果是很难令人满意的。下面我就先说一种最常见的MD5应用失败的形式。

  18. MD5优化算法及安全性分析%Analysis of MD5 Optimization Algorithm and Safety

    Institute of Scientific and Technical Information of China (English)

    张双斌

    2009-01-01

    针对目前MD5基本算法加密结果容易被破解的问题,在研究分析MD5、SHA-1及其系列算法加密原理的基础上,提出一种增加消息摘要长度的优化算法,使得破解时碰撞的概率减少很多倍,增强了系统加密的安全性.安全分析结果表明,MD5优化算法在保留了原算法加密速度的前提下,具有较原算法更好的抗攻击能力.

  19. A High Throughput FPGA Implementation of MD5 Algorithm%一种高吞吐量MD5算法的FPGA实现

    Institute of Scientific and Technical Information of China (English)

    刘凯; 车明; 秦存秀

    2008-01-01

    MD5数字摘要算法在网络安全的诸多方面都得到广泛的应用.由于其串行计算的特点,对MD5算法的加速并不像其它具有并行操作算法那样容易实现.提出了采用4级流水线的结构来提高MD5运算的吞吐量,可以提升至吉比特级.在设计中,参考了分布式存储模型的结构来实现低延迟、低资源消耗及更好的可扩展性.

  20. HMAC-MD5的 FPGA 优化与实现%FPGA Optimization and Implementation of HMAC-MD5 Algorithm

    Institute of Scientific and Technical Information of China (English)

    蔡啸; 李树国

    2015-01-01

    Data integrity and authenticity are very important in field of information security.HMAC-MD5 algorithm is one of the algorithms that achieve this target.The performance of its software implementation is very low and its FPGA hardware implementation is much higher.For the sake of higher throughput,this paper propose a two-to-one structure.As the result,it costs only 33 cycles to process 5 12 bits data.At the same time,the design support three kinds of mode:HMAC-MD5 computation with Key,HMAC-MD5 computation without key,MD5 computation. The design contains many optimization strategies such as pre-computation, microinstruction controller, the resources reuse etc.After synthesizing by Quartus II 13.0 on Stratix III devices,the clock frequency reaches 100 MHz,the throughput reaches 1.55 Gb/s and 1 120 ALUTs logic resources have been used.%在信息安全领域,数据完整性和真实性是十分重要的.HMAC-MD5算法是实现数据完整性和真实性验证的一种算法.HMAC-MD5的软件实现性能较低,而它的 FPGA 硬件实现性能较高.为了提高 FPGA 实现的性能,提出了一种二合一的结构,处理512 bit 数据周期数降低至33拍,提高了吞吐率,同时能够支持 HMAC-MD5带密钥输入和不带密钥输入、单 MD5运算的模式选择.本设计在 Stratix III 器件上使用 QuartusII 13.0进行综合,在使用了预计算、微指令控制器、资源复用等优化策略之后,最终综合出时钟频率为100 MHz,吞吐率达到1.55 Gb/s,逻辑资源使用为1120 ALUTs.

  1. Authentication in Networking Environment Based on LECC and MD5 Algorithm%基于LECC和MD5算法的网络身份认证

    Institute of Scientific and Technical Information of China (English)

    王小冬; 周海燕

    2015-01-01

    MD5算法常用于对远程用户进行身份认证,但其抵挡不了查字典或差分攻击.本文对用户身份进行MD5加密后,再采用LECC对密文进行纠错编码,提高算法抵御防攻击的能力.理论和实践证明,本算法具有较高的安全性和实用价值.

  2. Application of MD5 Algorithm in Office Automation System%MD5算法在办公自动化系统中的应用

    Institute of Scientific and Technical Information of China (English)

    张智发

    2008-01-01

    该文对办公自动化系统面临的风险进行了分析,介绍了MD5算法的特点和原理,把MD5算法应用于办公自动化系统中,解决了密码保护、信息完整性验证和数字签名等安全问题, 并给出了具体实现方法.

  3. 一种基于MD5算法的B/S通信加密系统%A MD5-based B/S communication encryption system

    Institute of Scientific and Technical Information of China (English)

    申甲

    2010-01-01

    随着网络的全面应用,以Web方式对数据进行操作的安全问题日益突出.本文针对目前广泛应用的MD5(Message Digest 5)加密算法,深入分析了MD5算法加密原理及实现过程,并利用该算法设计实现一种基于B/S(Browser/Server)方式的通信加密系统,达到了信息保密的要求.

  4. Milestone report on MD potential development for uranium silicide

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Jianguo [Idaho National Lab. (INL), Idaho Falls, ID (United States). Fuel Modeling and Simulation Dept.; Zhang, Yongfeng [Idaho National Lab. (INL), Idaho Falls, ID (United States). Fuel Modeling and Simulation Dept.; Hales, Jason Dean [Idaho National Lab. (INL), Idaho Falls, ID (United States). Fuel Modeling and Simulation Dept.

    2016-03-01

    This report summarizes the progress on the interatomic potential development of triuranium-disilicide (U3Si2) for molecular dynamics (MD) simulations. The development is based on the Tersoff type potentials for single element U and Si. The Si potential is taken from the literature and a Tersoff type U potential is developed in this project. With the primary focus on the U3Si2 phase, some other U-Si systems such as U3Si are also included as a test of the transferability of the potentials for binary U-Si phases. Based on the potentials for unary U and Si, two sets of parameters for the binary U-Si system are developed using the Tersoff mixing rules and the cross-term fitting, respectively. The cross-term potential is found to give better results on the enthalpy of formation, lattice constants and elastic constants than those produced by the Tersoff mixing potential, with the reference data taken from either experiments or density functional theory (DFT) calculations. In particular, the results on the formation enthalpy and lattice constants for the U3Si2 phase and lattice constants for the high temperature U3Si (h-U3Si) phase generated by the cross-term potential agree well with experimental data. Reasonable agreements are also reached on the elastic constants of U3Si2, on the formation enthalpy for the low temperature U3Si (m-U3Si) and h-U3Si phases, and on the lattice constants of m-U3Si phase. All these phases are predicted to be mechanically stable. The unary U potential is tested for three metallic U phases (α, β, γ). The potential is found capable to predict the cohesive energies well against experimental data for all three phases. It matches reasonably with previous experiments on the lattice constants and elastic constants of αU.

  5. Collision Attack on the Full Extended MD4 and Pseudo-Preimage Attack on RIPEMD

    Institute of Scientific and Technical Information of China (English)

    Gao-Li Wang

    2013-01-01

    The cryptographic hash functions Extended MD4 and RIPEMD are double-branch hash functions,which consist of two parallel branches.Extended MD4 was proposed by Rivest in 1990,and RIPEMD was devised in the framework of the RIPE project (RACE Integrity Primitives Evaluation,1988~1992).On the basis of differential analysis and meet-in-the-middle attack principle,this paper proposes a collision attack on the full Extended MD4 and a pseudo-preimage attack on the full RIPEMD respectively.The collision attack on Extended MD4 holds with a complexity of 237,and a collision instance is presented.The pseudo-preimage attack on RIPEMD holds with a complexity of 2125,4,which optimizes the complexity order for brute-force attack.The results in this study will also be beneficial to the analysis of other double-branch hash functions such as RIPEMD-160.

  6. 好压的MD5校验功能

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    为了防止人为篡改文件.一般网上供网民下载的文件都公布了其MD5校验值,下载到本机后通过比较MD5校验值是否发生变化来判断文件是否被篡改。先选中文件,再点击好压软件“工具”菜单里的“MD5校验工具”就可查看到该文件的相关校验,可以对任意文件进行版本、文件时间、MD5值、SHAl值和CRC32值进行校验。

  7. MD5加密验证拿下

    Institute of Scientific and Technical Information of China (English)

    Crack

    2005-01-01

    在软件的加密保护中,MD5是一个经常会被用到的加密算法,但是由于MD5算法为不可逆算法所以所有的软件都只能使用MD5算法作为一个加密的中间步骤,比如对用户名做一个MD5变换,结果再进行一个可逆的加密变换,变换结果为注册码;

  8. 感受MD5暴力破解的魅力

    Institute of Scientific and Technical Information of China (English)

    冰河洗剑

    2005-01-01

    MD5密码一直是最头疼的,许多论坛和网站的密码都是MD5加密过的。当然得到了MD5加密过的密码后.有的高手可以通过Cookie欺骗或Session欺骗等方式.进入后台管理页面,但是对许多朋友来说,暴力破解MD5密码.将其还原为明文密码.再登录后台虽然有些笨.但却是比较简单有效的一种方法。

  9. 简单编写MD5破解器

    Institute of Scientific and Technical Information of China (English)

    人鱼姬

    2007-01-01

    目前国内的网络安全现状不容乐观.脚本注入还大有市场。许多脚本小子喜欢用注入工具到处乱注.拿到了管理员密码的MD5密文就开始破解,但并不是所有人都知道MD5破解是如何实现的。下面我们就用Delphi来编写一款简单的MD5破解器.同时让大家更清晰地了解MD5破解是基于什么原理实现的。

  10. 在线破解MD5网站一览

    Institute of Scientific and Technical Information of China (English)

    Tashanenjoy

    2006-01-01

    MD5加密因其不可逆性而导致了一些爆破猜测MD5工具的出现.如著名的MD5Crack.其原理是先进行MD5加密再对比提供的字符串。虽然速度也较快.但毕竟还是要“跑”一下具。有时一个密码跑30分钟也不一定能跑出来.很不划算。有没有其他的办法呢?

  11. 75 FR 12563 - Patuxent Research Refuge, Anne Arundel and Prince George's Counties, MD

    Science.gov (United States)

    2010-03-16

    ... Scarlet Tanager Loop, Laurel, MD 20708. FOR FURTHER INFORMATION CONTACT: Brad Knudsen, Refuge Manager... team leader or project leader (see ADDRESSES). You may also send comments anytime during the...

  12. EMC/FDTD/MD simulation of carrier transport and electrodynamics in two-dimensional electron systems

    OpenAIRE

    Sule, N; Willis, K. J.; Hagness, S. C.; Knezevic, I.

    2014-01-01

    We present the implementation and application of a multiphysics simulation technique to carrier dynamics under electromagnetic excitation in supported two-dimensional electronic systems. The technique combines ensemble Monte Carlo (EMC) for carrier transport with finite-difference time-domain (FDTD) for electrodynamics and molecular dynamics (MD) for short-range Coulomb interactions among particles. We demonstrate the use of this EMC/FDTD/MD technique by calculating the room-temperature dc an...

  13. 下载软件的MD5你检验了吗?

    Institute of Scientific and Technical Information of China (English)

    胥忠亮

    2009-01-01

    大家经常在网上下东西.可是下载下来的软件很有可能带有木马。通常软件发布者在发布软件的时候会附上软件的MD5.来防止软件被他人篡改。那程序的MD5值是什么呢?

  14. 软件保护中MD5算法的另类应用

    Institute of Scientific and Technical Information of China (English)

    TC—XB

    2006-01-01

    作为一种主流的加密算法,MD5算法广泛的应用于软件保护领域。在软件的注册保护中,MD5经常被用来对输入的注册信息进行加密。一般来说较为简单常见的用法是“MD5(注册名)=注册码”或是“MD5(注册名:机器码)=注册码”。这样的加密方法有一定的保护效果,但是随着破解技术的进步,对于这种保护方式,破解者只要能判断出使用了MD5算法,就可以很方便的做出注册机。不过不能因此否认MD5算法的优越性,所以对于MD5在软件的保护中应用,就要另辟蹊径了。下文中我们以一个Crackme为例,来看看如何更有效的使用MD5算法,并产生更好的保护效果。

  15. Summary of LHC MD 369: DOROS vs WBTN in IR Stripline BPMs

    CERN Document Server

    Draskovic, Drasko; Calvo Giraldo, Eva; Olexa, Jakub; Gasior, Marek; CERN. Geneva. ATS Department

    2015-01-01

    The aim of this MD is to quantify the impact of the stripline beam position monitor (BPM) directivity with two acquisition chain electronics systems, WBTN (Wide Band Time Normalizer) and DOROS (Diode ORbit and Oscillation System). This impact depends on the relative position and intensity of the two beams at the location of the monitor. This note explains all the procedures of the LHC MD 369, which took place on 20/07/2015 and presents the obtained results.

  16. Parallel Cascade Selection Molecular Dynamics (PaCS-MD) to generate conformational transition pathway.

    Science.gov (United States)

    Harada, Ryuhei; Kitao, Akio

    2013-07-21

    Parallel Cascade Selection Molecular Dynamics (PaCS-MD) is proposed as a molecular simulation method to generate conformational transition pathway under the condition that a set of "reactant" and "product" structures is known a priori. In PaCS-MD, the cycle of short multiple independent molecular dynamics simulations and selection of the structures close to the product structure for the next cycle are repeated until the simulated structures move sufficiently close to the product. Folding of 10-residue mini-protein chignolin from the extended to native structures and open-close conformational transition of T4 lysozyme were investigated by PaCS-MD. In both cases, tens of cycles of 100-ps MD were sufficient to reach the product structures, indicating the efficient generation of conformational transition pathway in PaCS-MD with a series of conventional MD without additional external biases. Using the snapshots along the pathway as the initial coordinates, free energy landscapes were calculated by the combination with multiple independent umbrella samplings to statistically elucidate the conformational transition pathways.

  17. 不要宰牛刀,MD5值校对更方便

    Institute of Scientific and Technical Information of China (English)

    新玲的窗户

    2009-01-01

    在一些比较正规的网站或论坛下载软件时,在软件下载链接旁边一般都会提供该软件原始的MD5值。用MD5值工具计算出下载软件的MD5值,和原始MD5值进行校对,就可判断出下载的软件是否被修改过。但是,使用专门的工具对下载的软件进行MD5值校对比较麻烦,二来也有“杀鸡用牛刀”之嫌。其实,仅仅利用一个动态链接库文件,就可以完成MD5值的校对工作。

  18. 防止密码MD5值被破解妙招

    Institute of Scientific and Technical Information of China (English)

    晏伟

    2006-01-01

    现在的站点当中有很多密码都是经过MD5加密的,有很多人认为经过MD5加密后的密码就是安全的,即使密码MD5值被暴露也无所谓,殊不知有很多站点都能够对MD5值进行穷举解密,这些站点能够在瞬间还原1O位以下字母+数字+字符组合的密码。有些站点甚至声称数据库中有235亿条记录,这是件很可怕的事情,如果你的密码不够强大,只是由简单数字或几个字母组成,MD5值也相当于是明文!下面我就教大家一招防止MD5值被破解的妙招。

  19. Novel matrine derivative MD-1 attenuates hepatic fibrosis by inhibiting EGFR activation of hepatic stellate cells.

    Science.gov (United States)

    Feng, Yi; Ying, Hai-Yan; Qu, Ying; Cai, Xiao-Bo; Xu, Ming-Yi; Lu, Lun-Gen

    2016-09-01

    Matrine (MT), the effective component of Sophora flavescens Ait, has been shown to have anti-inflammation, immune-suppressive, anti-tumor, and anti-hepatic fibrosis activities. However, the pharmacological effects of MT still need to be strengthened due to its relatively low efficacy and short half-life. In the present study, we report a more effective thio derivative of MT, MD-1, and its inhibitory effects on the activation of hepatic stellate cells (HSCs) in both cell culture and animal models. Cytological experiments showed that MD-1 can inhibit the proliferation of HSC-T6 cells with a half-maximal inhibitory concentration (IC50) of 62 μmol/L. In addition, MD-1 more strongly inhibits the migration of HSC-T6 cells compared to MT and can more effectively induce G0/G1 arrest and apoptosis. Investigating the biological mechanisms underlying anti-hepatic fibrosis in the presence of MD-1, we found that MD-1 can bind the epidermal growth factor receptor (EGFR) on the surface of HSC-T6 cells, which can further inhibit the phosphorylation of EGFR and its downstream protein kinase B (Akt), resulting in decreased expression of cyclin D1 and eventual inhibition of the activation of HSC-T6 cells. Furthermore, in rats with dimethylnitrosamine (DMN)-induced hepatic fibrosis, MD-1 slowed the development and progression of hepatic fibrosis, protecting hepatic parenchymal cells and improving hepatic functions. Therefore, MD-1 is a potential drug for anti-hepatic fibrosis.

  20. Evaluation of hydroacid complex in the forward osmosis–membrane distillation (FO–MD) system for desalination

    KAUST Repository

    Wang, Peng

    2015-11-01

    The incorporation of membrane distillation (MD) into forward osmosis (FO) provides process sustainability to regenerate the draw solution and to produce clean water simultaneously. However, the reverse salt flux is the major hurdle in the FO-MD system because it not only reduces the effective osmotic driving force across the membrane but also increases the replenishment cost and scaling issue. For the first time, a hydroacid complex with abundant hydrophilic groups and ionic species is evaluated as the draw solutes in the hybrid FO-MD system consisting of multi-bore PVDF MD membranes for seawater/brackish desalination. In order to evaluate the practicality of the hydroacid complex in the FO-MD system, FO and MD experiments were conducted at elevated temperatures and concentrations. The hydroacid complex has displayed desired properties such as high solubility, low viscosity, excellent thermal stability and minimal reverse salt flux suitable for FO and MD operations. FO-MD desalination process was demonstrated with a highest seawater desalination flux of 6/32 LMH (FO/MD). This study may open up the prospective of employing the hydroacid complex as the draw solute in FO-MD hybrid systems for seawater /brackish desalination. © 2015 Elsevier B.V.

  1. PuReMD-GPU: A reactive molecular dynamics simulation package for GPUs

    Energy Technology Data Exchange (ETDEWEB)

    Kylasa, S.B., E-mail: skylasa@purdue.edu [Department of Elec. and Comp. Eng., Purdue University, West Lafayette, IN 47907 (United States); Aktulga, H.M., E-mail: hmaktulga@lbl.gov [Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, MS 50F-1650, Berkeley, CA 94720 (United States); Grama, A.Y., E-mail: ayg@cs.purdue.edu [Department of Computer Science, Purdue University, West Lafayette, IN 47907 (United States)

    2014-09-01

    We present an efficient and highly accurate GP-GPU implementation of our community code, PuReMD, for reactive molecular dynamics simulations using the ReaxFF force field. PuReMD and its incorporation into LAMMPS (Reax/C) is used by a large number of research groups worldwide for simulating diverse systems ranging from biomembranes to explosives (RDX) at atomistic level of detail. The sub-femtosecond time-steps associated with ReaxFF strongly motivate significant improvements to per-timestep simulation time through effective use of GPUs. This paper presents, in detail, the design and implementation of PuReMD-GPU, which enables ReaxFF simulations on GPUs, as well as various performance optimization techniques we developed to obtain high performance on state-of-the-art hardware. Comprehensive experiments on model systems (bulk water and amorphous silica) are presented to quantify the performance improvements achieved by PuReMD-GPU and to verify its accuracy. In particular, our experiments show up to 16× improvement in runtime compared to our highly optimized CPU-only single-core ReaxFF implementation. PuReMD-GPU is a unique production code, and is currently available on request from the authors.

  2. A Study of the Adsorption of Molecular Deposition Filming Flooding Agent MD-1 on Quartz Sand

    Institute of Scientific and Technical Information of China (English)

    GaoManglai; LiuYong; MengXiuxia; WangJianshe

    2004-01-01

    Molecular deposition filming flooding (MDFF) is a novel oil recovery technique based on the thermopositive monolayer electrostatic adsorption of the MDFF agent on different interfaces within reservoir systems. In this paper, the adsorption property of the MDFF agent, MD-I, on quartz sand has been studied through adsorption experiments at different pH and temperatures. Experimental data are also analyzed kinetically and thermodynamically. The results show that the adsorption of MD-I on quartz sand takes place mainly because of electrostatic interactions, which corresponds to adsorption that increases with pH. Kinetic analyses show that at a higher pH the activation energy for adsorption gets lower and, therefore, the adsorption becomes quicker for MD-1 on quartz sand. Thermodynamic analyses show that pH plays an important role in the adsorption of MD-1 on quartz sand. At a higher pH, more negative surface charges result in the increase of electrostatic interactions between MD-1 and quartz sand. Therefore, the saturated adsorption amount increases and more adsorption heat will be released.

  3. Chosen-Prefix Collisions for MD5 and Colliding X.509 Certificates for Different Identities

    Science.gov (United States)

    Stevens, Marc; Lenstra, Arjen; de Weger, Benne

    We present a novel, automated way to find differential paths for MD5. As an application we have shown how, at an approximate expected cost of 250 calls to the MD5 compression function, for any two chosen message prefixes P and P', suffixes S and S' can be constructed such that the concatenated values P||S and P'||S' collide under MD5. Although the practical attack potential of this construction of chosen-prefix collisions is limited, it is of greater concern than random collisions for MD5. To illustrate the practicality of our method, we constructed two MD5 based X.509 certificates with identical signatures but different public keys and different Distinguished Name fields, whereas our previous construction of colliding X.509 certificates required identical name fields. We speculate on other possibilities for abusing chosen-prefix collisions. More details than can be included here can be found on www.win.tue.nl/hashclash/ChosenPrefixCollisions/.

  4. Implementation of MD5 Fast Crack Based on GPU Cluster%基于GPU集群实现MD5的快速破解

    Institute of Scientific and Technical Information of China (English)

    杨胜斌

    2013-01-01

    从单个GPU异构并行系统来看,其性能还是比较有限,文章阐述了基于GPU集群的CUDA架构实现过程,详细分析基于GPU集群进行MD5快速破解的编译过程,并对破解程序进行测试研究,对其运行结果进行测试和分析,探讨搭建GPU高性能计算集群及其进行MD5算法的快速破解的过程.

  5. MD5和DES算法在市政网络平台中的应用%Municipal network platform based on md5 funtion and DES algrithm

    Institute of Scientific and Technical Information of China (English)

    邓中亮; 曹其可; 葛悦涛

    2011-01-01

    鉴于市政管理数据中包含大量敏感信息,为解决目前移动终端访问市政平台所存在的安全问题,采用MD5和DES算法,设计一移动通信中间件,对现有的网络进行改进以实现平台的安全机制.MD5算法用采实现身份认证过程,DES算法结合非对称加密和数字签名技术来保证信息的安全传输.该中间件可以以动态库的形式集成在客户端设备与市政管委的Web服务器上,因此可以不需要对现有资源进行较大的改动,以较小的代价达到安全性目标,大大降低部署的难度.%As the database of municipal administration contains large amounts of sensitive information, we designed this mobile middleware to optimized the exsiting platform and protected the sensitive data be attacted. This middleware is based on MD5 and DES algorithm. MD5 algorithm is used to implement the authentication process. DES algorithm combined with asymmetric encryption and digital signature to ensure the safety of information transmission. The middleware can be integrated in the client device and the Web server of the municipal in the form of dynamic libraries. You can achieve the security goals without need to carry out major changes to the existing resources, greatly reduced the difficulty of deployment.

  6. 基于CUDA架构的MD5并行分析算法研究%Research of MD5 Parallel Algorithm Based on CUDA

    Institute of Scientific and Technical Information of China (English)

    张伟; 陈田国; 陶志荣

    2009-01-01

    在介绍了CUDA(统一计算设备架构)架构的基础上,给出了一种CUDA架构上进行MD5摘要分析的并行算法.算法有效利用了GPU的并行性和CUDA架构的优势实现了较快的运算速度,测试结果显示优于CPU的算法.

  7. MD5算法与Web口令的安全传输%MD5 Algorithm and Security Transfer of Web Password

    Institute of Scientific and Technical Information of China (English)

    丁振国; 刘斌

    2004-01-01

    在研究了现存的采用单向散列算法对口令加密传输机制的缺点的基础上,提出了一种用MD5算法加密口令的改进方案,不仅实现简单,而且有效地提高了Web认证系统中口令传输的安全性.

  8. 基于MD5与Base64的混合加密算法%MD5-Base64 based hybrid encryption algorithm

    Institute of Scientific and Technical Information of China (English)

    罗江华

    2012-01-01

    介绍了一种基于MD5和Base64的混合加密算法,首先将明文MD5加密得到32位16进制密文,再将32位密文拆分成16个2位16进制数组,并转换成对应的二进制数,最后将16个二进制数组连接成一个128位的2进制数,采用Base64加密原理进行加密.该算法可以避免查询MD5散列值字典获取用户明文密码,更加有效地保证了用户的密码安全,最后给出了算法的PHP实现.%A MD5-Base64 baaed hybrid encryption algorithm was introduced, which encrypted plain text to 32-bit hexadecimal cipher text by MDS encryption, then split this 32-bit hexadecimal into 16 parts, and transformed them into binary Cor each part to join them together as a 128-bit binary, finally, encrypted the 128-bit binary array by using Base64 algorithm. This algorithm can avoid getting user's clear text password by querying MDS hash database, and protect user's password more effectively. This algorithm was described by PHP script language at the fourth section.

  9. Web开发中MD5摘要计算的应用——Struts技术实现

    Institute of Scientific and Technical Information of China (English)

    鲁屹华

    2008-01-01

    M05的全称是Message-Digest Algorithm 5(信息-摘要算法),在90年代初由MIT Laboratory for Computer Science和RSA Data Security Inc的Ronald L.Rivest开发出来,经MD2、MD3和MD4发展而来.本文首先介绍了MD5算法的概念.然后阐述了Java语言的java.security包对MD5算法的支持,并基于Sun公司Java 2平台企业版(J2EE)MVC框架Struts技术,针对B/S模式毕业设计选题系统中的学生基本信息注册模块所采用的MD5摘要计算作了详细介绍.

  10. 改造MD5让破解程序见鬼去

    Institute of Scientific and Technical Information of China (English)

    安美洪

    2005-01-01

    也许提到MD5时大家都很熟,但你真的了解它吗?虽然一般人是不用这样去寻根问底的,要用的时候直接去下载别人已编好的程序用就得了,但象我这样的好事者总想抓住点什么另类的东西——你有没有想过自己修改MD5,让网上漫天飞的MD5破解工具变得一无是处?要是有兴趣就往下看吧!

  11. 在飞速网用MD5值搜索PE系统

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    如果你要测试某PE系统.可是很多专门下载网站的资源链接都已经失效,幸好对于操作系统这类资源.很多网站都提供下载资源的MD5值。现在只要记下失效链接网站提供的资源MD5值,然后在地址栏输入http://www.raylile.com/zh—cn/files/6FA887054AB3EE91A5F542227FDC7493(“files/”后面的内容即为要搜索文件的MD5值).回车后即可跳转到该资源的下载链接中。

  12. 基于FPGA的MD5算法设计与实现%Design and Implementation of MD5 Algorithm Based on FPGA

    Institute of Scientific and Technical Information of China (English)

    王波涛; 韩国栋; 张效军

    2010-01-01

    MD5算法在网络安全的诸多方面都得到广泛的应用,在一些特殊场合要求计算具有高处理速度,低资源占用率的特点.文中首先介绍了MD5算法的发展历程和算法原理,然后描述了该算法在FPGA上实现的整体架构,分析了其各模块的功能,最后给出了基于Altera公司的Stratix Ⅱ GX系列FPGA的实现结果.通过实验结果可以看出基于FPGA的MD5算法实现具有较高的处理速度和较少的资源占用,并可对设计进行适当修改来实现其它的摘要算法,具有一定的实用价值.

  13. The topology of foliations formed by the generic K-orbits of a subclass of the indecomposable MD5-groups

    Institute of Scientific and Technical Information of China (English)

    VU; Le; Anh; HOA; Duong; Quang

    2009-01-01

    The paper is a continuation of the authors’ works in 2007. We consider the MD5-foliations associated to connected and simply connected MD5-groups such that their Lie algebras have 4-dimensional commutative derived ideals. In this study, we give a topological classification of all considered MD5-foliations. A description of these foliations by certain fibrations or suitable actions of R2 and the Connes’ C*-algebras of the foliations which come from fibrations are also given.

  14. The topology of foliations formed by the generic K-orbits of a subclass of the indecomposable MD5-groups

    Institute of Scientific and Technical Information of China (English)

    VU Le Anh; HOA Duong Quang

    2009-01-01

    The paper is a continuation of the authors' works in 2007. We consider the MD5-foliations associated to connected and simply connected MD5-groups such that their Lie algebras have 4-dimensional commutative derived ideals. In this study, we give a topological classification of all considered MD5-foliations. A description of these foliations by certain fibrations or suitable actions of R2 and the Connes' C*-algebras of the foliations which come from fibrations are also given.

  15. PoopMD, a Mobile Health Application, Accurately Identifies Infant Acholic Stools

    OpenAIRE

    Amy Franciscovich; Dhananjay Vaidya; Joe Doyle; Josh Bolinger; Montserrat Capdevila; Marcus Rice; Leslie Hancock; Tanya Mahr; Mogul, Douglas B.

    2015-01-01

    Biliary atresia (BA) is the leading cause of pediatric end-stage liver disease in the United States. Education of parents in the perinatal period with stool cards depicting acholic and normal stools has been associated with improved time-to-diagnosis and survival in BA. PoopMD is a mobile application that utilizes a smartphone's camera and color recognition software to analyze an infant's stool and determine if additional follow-up is indicated. PoopMD was developed using custom HTML5/CSS3 an...

  16. Usefulness of multidetector-row CT (MD-CT) for assessment of coronary artery stenosis

    International Nuclear Information System (INIS)

    Coronary arteries stenosis were evaluated in 49 cases by volume rendering (VR) and partial maximum intensity projection (partial MIP) using multidetector-row CT (MD-CT). Left main trunk (LMT) and left anterior descending artery (LAD) were less affected by cardiac pulsation artifact and presented good images. Right coronary artery (RCA) was affected by cardiac pulsation artifact and image quality was inferior as compared to left coronary artery (LCA). It is suggested that MD-CT is useful for assessment of coronary artery stenosis, especially LCA. (author)

  17. LHC Transvers Profile Monitors studies (MD on May 6th, 2011)

    CERN Document Server

    Bravin, E; Dehning, B; Emery, J; Lefevre, T; Gras, JJ; Jeff, A; Rabiller, A; Roncarolo, F; Sapinski, M; Kain, V; Pojer, M; Bartosik, H; Salvant, B

    2011-01-01

    This note contains the preliminary results of the LHC MD that took place on 6-May-2011 (from 2 to 10 a.m.), dedicated to study Wire Scanners (WS), Synchrotron Radiation Monitors (BSRT) and Beam Gas Ionization Monitors (BGI). The MD aimed at performing different studies on the individual monitors as well as at cross calibrating them with beams composed of bunches with different transverse emittances in stable conditions. At the same time, it was possible to perform calibration studies with the Abort Gap Monitor (AGM) and Longitudinal Density Monitor (LDM) that share the extracted light with the BSRT.

  18. MD5解密器速度加强版V2.2

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    MD5密码的破解软件很多.今天介绍的这款MD5解密器速度加强版是原作者在此软件V2.0的基础上去除了影响速度的功能.并对加密算法进行了修改的结果.速度比同类解密器快了非常多。

  19. Computation of shear viscosity of colloidal suspensions by SRD-MD

    Energy Technology Data Exchange (ETDEWEB)

    Laganapan, A. M. K.; Videcoq, A., E-mail: arnaud.videcoq@unilim.fr; Bienia, M. [SPCTS, UMR 7315, ENSCI, CNRS, Centre Européen de la Céramique, 12 rue Atlantis, 87068 Limoges Cedex (France); Ala-Nissila, T. [COMP CoE at the Department of Applied Physics, Aalto University School of Science, P.O. Box 11000, FIN-00076 Aalto, Espoo (Finland); Department of Physics, Brown University, Providence, Rhode Island 02912-1843 (United States); Bochicchio, D.; Ferrando, R. [Dipartimento di Fisica and CNR-IMEM, via Dodecaneso 33, Genova I-16146 (Italy)

    2015-04-14

    The behaviour of sheared colloidal suspensions with full hydrodynamic interactions (HIs) is numerically studied. To this end, we use the hybrid stochastic rotation dynamics-molecular dynamics (SRD-MD) method. The shear viscosity of colloidal suspensions is computed for different volume fractions, both for dilute and concentrated cases. We verify that HIs help in the collisions and the streaming of colloidal particles, thereby increasing the overall shear viscosity of the suspension. Our results show a good agreement with known experimental, theoretical, and numerical studies. This work demonstrates the ability of SRD-MD to successfully simulate transport coefficients that require correct modelling of HIs.

  20. MD5算法及在用户口令加密应用中的改进

    Institute of Scientific and Technical Information of China (English)

    高洪波; 马素萍

    2010-01-01

    MD5是一种非常优秀的加密算法,曾被大量公司和个人广泛使用。但随着科学技术的发展,MD5牢不可破的神话逐渐破灭。基于此,在分析MD5加密算法及其弱点的前提下,探讨了MD5的改进算法。

  1. 76 FR 60889 - Stephen L. Reitman, M.D.; Decision and Order

    Science.gov (United States)

    2011-09-30

    ... Friedel 57. Dr. William Friedel is a graduate of Brown University. He attended Albert Einstein College of Medicine, interned at Downstate in Brooklyn, New York, and returned to Albert Einstein for his residency in... substances properly if entrusted with a DEA registration.''' Id. (quoting Leonardo v. Lopez, M.D., 54...

  2. 76 FR 80230 - Amendment of Class D and E Airspace; Baltimore, MD

    Science.gov (United States)

    2011-12-23

    ... FR 72837). This action further corrects the geographic coordinates to be in concert with the FAAs..., 2011, 76 FR 72837, FR Doc. 2011-30489, are corrected as follows: AEA MD D Baltimore, Martin State... the geographic coordinates in the airspace description of a final rule published in the...

  3. An endophytic taxol-producing fungus from Taxus media, Cladosporium cladosporioides MD2.

    Science.gov (United States)

    Zhang, Peng; Zhou, Peng-Peng; Yu, Long-Jiang

    2009-09-01

    Fermentation processes using taxol-producing fungi other than Taxus spp. may be an alternative way to produce taxol, which is an important antitumor agent used widely in the clinic setting. In this study, a taxol-producing endophytic fungus strain MD2 was isolated from the inner bark of Taxus media. Strain MD2 produced taxol when grown in potato dextrose liquid medium. The fungal taxol-which was analyzed by ultraviolet, high-performance liquid chromatography and mass spectrometry-was shown to be identical to authentic taxol and 10-deacetylbaccatin III. Further analysis with nuclear magnetic resonance (NMR) spectroscopy to show the chemical structure of the fungal taxol indicated that the fungal taxol produced an NMR spectrum identical to that of authentic taxol. Strain MD2 was identified as Cladosporium cladosporioides according to morphology of the fungal culture, characteristics of the spores, and analysis of 18S rDNA sequence. In addition, 10-deacetylbaccatin III-10-O-acetyl transferase gene of C. cladosporioides MD2 was cloned for the first time and was shown to share 99% identity with that of T. x media and 97% identity with that of T. wallichiana var. mairei.

  4. 77 FR 57126 - Henri Wetselaar, M.D.; Decision and Order

    Science.gov (United States)

    2012-09-17

    ... Enforcement Administration Henri Wetselaar, M.D.; Decision and Order On September 27, 2011, I, the... * * * so you're making some pretty big steps already.'' Id. The TFO expressed his appreciation, and... he took a whole one at night to help him sleep, a whole one in the morning, and that he...

  5. Novel plasmid conferring kanamycin and tetracycline resistance in turkey-derived Campylobacter jejuni strain 11601MD

    Science.gov (United States)

    In Campylobacter spp., resistance to the antibiotics kanamycin and tetracycline is frequently associated with plasmid-borne genes. However, relatively few plasmids of Campylobacter jejuni have been fully characterized to date. A novel plasmid (p11601MD; 44,095 bp.) harboring tet(O) was identified in...

  6. Large-scale MD simulations investigating H plasma interactions with Tungsten surfaces

    Science.gov (United States)

    Cusentino, Mary Alice; Wirth, Brian

    2015-11-01

    Tungsten is a prime candidate material for the divertor in future fusion reactors such as ITER. However, the tungsten divertor will need to be able to withstand high fluxes, on the order of 1024m-2s-1, of low energy hydrogen. It is crucial to understand both the tungsten surface response as well as the hydrogen retention and recycling for the divertor region. Molecular dynamics (MD) is a useful tool to study these effects. One issue with MD is that implantation fluxes tend to be very high, on the order of 1027 m-2s-1, due to time and computational limitations. By performing large scale MD on supercomputers, it is possible to reach more realistic fluxes of 1025 m-2s-1. Results will be presented from MD simulations from a 50 nm x 50 nm x 25 nm tungsten box at 1200 K and 2000 K. Hydrogen is implanted every 10 ps based on the 60 eV depth distribution calculated by SRIM, which amounts to a flux of 4 x 1025 m-2s-1. A modified version of the Juslin bond order W-H potential is used to describe the W-H interactions. Preliminary results show an initially high retention of hydrogen that accumulates in a sub-surface region. These simulations provide insight into the early stages of surface deformation as well as hydrogen retention for the tungsten divertor.

  7. Draft Genome Sequence of Lactobacillus jensenii Strain MD IIE-70(2)

    OpenAIRE

    Karlyshev, Andrey V.; Nadarajah, Sindhujan; Abramov, Vyacheslav M.

    2013-01-01

    A draft genome sequence of Lactobacillus jensenii strain MD IIE-70(2) was determined using Ion PGM technology. The reads were mapped to a reference strain and assembled using a combination of tools. The genetic features revealed in this study will assist in understanding the probiotic properties of Lactobacillus bacteria.

  8. Draft Genome Sequence of Lactobacillus jensenii Strain MD IIE-70(2).

    OpenAIRE

    Karlyshev, Andrey V.; Nadarajah, Sindhujan; Abramov, Vyacheslav M.

    2013-01-01

    A draft genome sequence of Lactobacillus jensenii strain MD IIE-70(2) was determined using Ion PGM technology. The reads were mapped to a reference strain and assembled using a combination of tools. The genetic features revealed in this study will assist in understanding the probiotic properties of Lactobacillus bacteria.

  9. 78 FR 76169 - Patuxent Research Refuge, Prince George's and Anne Arundel Counties, MD; Final Comprehensive...

    Science.gov (United States)

    2013-12-16

    .... Geological Survey (USGS) Patuxent Wildlife Research Center, a leading international research institute for... Fish and Wildlife Service Patuxent Research Refuge, Prince George's and Anne Arundel Counties, MD... significant impact (FONSI) for Patuxent Research Refuge (Patuxent RR, refuge), located in Prince George's...

  10. 75 FR 49992 - Peter W.S. Grigg, M.D.; Revocation of Registration

    Science.gov (United States)

    2010-08-16

    ... * * * considered in the disjunctive.'' Robert A. Leslie, M.D., 68 FR 15227, 15230 (2003). I ``may rely on any one...). However, under Agency precedent, neither of these findings is dispositive. See Edmund Chein, 72 FR 6580, 6590 n.22 (2007); Mortimer B. Levin, 55 FR 8209, 8210 (1990). Moreover, the evidence with respect...

  11. 77 FR 45675 - Margy Temponeras, M.D.; Decision and Order

    Science.gov (United States)

    2012-08-01

    ... that Mrs. Leadingham similarly stated that ``she was there to dispense the medication and put the... medication to patients.'' (Id.) The location was described as having the doctor's office on the left of the... encompasses the factors listed in Section 824(a).'' ALJ at 19 n.24 (citing Kuen H. Chen, M.D., 58 FR...

  12. 77 FR 23599 - Special Local Regulations for Marine Events; Potomac River, Charles County, MD

    Science.gov (United States)

    2012-04-20

    ... regulations to the Small Business and Agriculture Regulatory Enforcement Ombudsman and the Regional Small...; Potomac River, Charles County, MD'' in the Federal Register (77 FR 27). We received one comment on the... substantial number of small entities. The term ``small entities'' comprises small businesses,...

  13. Short Chosen-Prefix Collisions for MD5 and the Creation of a Rogue CA Certificate

    NARCIS (Netherlands)

    Stevens, M.M.J.; Sotirov, A.; Appelbaum, J.; Lenstra, A.K.; Molnar, D.; Osvik, D.A.; Weger, B. de

    2009-01-01

    We present a refined chosen-prefix collision construction for MD5 that allowed creation of a rogue Certification Authority (CA) certificate, based on a collision with a regular end-user website certificate provided by a commercial CA. Compared to the previous construction from Eurocrypt 2007, this p

  14. Heat Flow Data Cruise MD72 RV Marion Dufresne over the Mascarene Ridge

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Data were gathered by the R/V Marion Dufresne in May and June of 1992 over the Mascarene Ridge in the Indian Ocean on cruise MD72/MASCAFLUX. Heat flow measurements...

  15. 76 FR 31235 - Safety Zone; Ocean City Air Show, Atlantic Ocean, Ocean City, MD

    Science.gov (United States)

    2011-05-31

    ... Ocean City, Maryland. (b) Definition: For purposes of enforcement of this section, Captain of the Port... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Ocean City Air Show, Atlantic Ocean, Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Temporary Final rule. SUMMARY: The Coast Guard...

  16. PHYSICAL PROPERTIES OF NEAR-EARTH ASTEROID 2011 MD

    Energy Technology Data Exchange (ETDEWEB)

    Mommert, M.; Trilling, D. E. [Department of Physics and Astronomy, Northern Arizona University, P.O. Box 6010, Flagstaff, AZ 86011 (United States); Farnocchia, D.; Chesley, S. R.; Chodas, P. W. [Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109 (United States); Hora, J. L.; Smith, H. A.; Fazio, G. G. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, MS 65, Cambridge, MA 02138-1516 (United States); Mueller, M. [SRON Netherlands Institute for Space Research, Postbus 800, 9700-AV Groningen (Netherlands); Harris, A. W. [DLR Institute of Planetary Research, Rutherfordstrasse 2, D-12489 Berlin (Germany)

    2014-07-01

    We report on observations of near-Earth asteroid 2011 MD with the Spitzer Space Telescope. We have spent 19.9 hr of observing time with channel 2 (4.5 μm) of the Infrared Array Camera and detected the target within the 2σ positional uncertainty ellipse. Using an asteroid thermophysical model and a model of nongravitational forces acting upon the object, we constrain the physical properties of 2011 MD, based on the measured flux density and available astrometry data. We estimate 2011 MD to be (6{sub −2}{sup +4}) m in diameter with a geometric albedo of 0.3{sub −0.2}{sup +0.4} (uncertainties are 1σ). We find the asteroid's most probable bulk density to be (1.1{sub −0.5}{sup +0.7}) g cm{sup –3}, which implies a total mass of (50-350) t and a macroporosity of ≥65%, assuming a material bulk density typical of non-primitive meteorite materials. A high degree of macroporosity suggests that 2011 MD is a rubble-pile asteroid, the rotation of which is more likely to be retrograde than prograde.

  17. 76 FR 16823 - Robert L. Dougherty, M.D.; Denial of Application

    Science.gov (United States)

    2011-03-25

    ... previously held a DEA Certificate of Registration as a practitioner. Robert L. Dougherty, Jr., M.D., 60 FR... prescribing of controlled substances to three patients. Id. (citing 60 FR 55047). More specifically, the Show... treatment record of Patient 1 could have ultimately jeopardized that patient's welfare.'' 60 FR at 55051....

  18. 78 FR 62666 - Kenneth Harold Bull, M.D.; Decision and Order

    Science.gov (United States)

    2013-10-22

    ... to 100 patients for opiate addiction with Suboxone and Subutex under the Drug Addiction Treatment Act... factors are . . . considered in the disjunctive.'' Robert A. Leslie, M.D., 68 FR 15227, 15230 (2003). It... Krishna-Iyer, 74 FR 459, 462 (2009). Accordingly, as the Tenth Circuit has recognized, findings under...

  19. 78 FR 19012 - Pawan Kumar Jain, M.D.; Decision And Order

    Science.gov (United States)

    2013-03-28

    ...., 65 FR 5,661 (DEA 2000); Jesus R. Juarez, M.D., 62 FR 14,945 (DEA 1997). Accordingly, both the plain... to practice medicine or handle controlled substances in the State of New Mexico'' and Respondent's... alleged that the New Mexico State Medical Board took action against the Respondent on June 28, 2012. ....

  20. 76 FR 60873 - Jeffery M. Freesemann, M.D.; Decision and Order

    Science.gov (United States)

    2011-09-30

    ... will not engage in future misconduct. Cf. Ronald Lynch, M.D., 75 FR 78745, 78749 (2010). Order Pursuant..., and psilocybin mushrooms (psilocybin or mushrooms). Gov't Exs. 4, 8; Tr. 99. More specifically, the...; \\26\\ and 0.8 grams of psilocybin mushrooms.\\27\\ Gov't Ex. 4. While most of the drugs that were...

  1. Electrochemical endotoxin sensors based on TLR4/MD-2 complexes immobilized on gold electrodes.

    Science.gov (United States)

    Yeo, Tae Yun; Choi, Ji Suk; Lee, Byung Kook; Kim, Beob Soo; Yoon, Hwa In; Lee, Hyeong Yun; Cho, Yong Woo

    2011-10-15

    Even low concentrations of endotoxins can be life-threatening. As such, continuous effort has been directed toward the development of sensitive and specific endotoxin detection systems. In this paper, we report the design and fabrication of a new electrochemical endotoxin sensor based on a human recombinant toll-like receptor 4 (rhTLR4) and myeloid differentiation-2 (MD-2) complex. The rhTLR4/MD-2 complex, which specifically binds to endotoxin, was immobilized on gold electrodes through a self-assembled monolayer (SAM) technique involving the use of dithiobis(succinimidyl undecanoate) (DSU). The surface topography of the electrodes at each fabrication stage was characterized with a nanosurface profiler and atomic force microscope (AFM). The electrochemical signals generated from interactions between the rhTLR4/MD-2 complex and the endotoxin were characterized by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). A linear relationship between the peak current and endotoxin concentration was obtained in the range of 0.0005 to 5 EU/mL with a correlation coefficient (R(2)) of 0.978. The estimated limit of detection (LOD) was fairly low, 0.0002 EU/mL. The rhTLR4/MD-2 based sensors exhibited no current responses to dipalmitoylphosphatidylcholine (DPPC) bearing two lipid chains, which is structurally similar to endotoxin, indicating the high specificity of the sensors to endotoxin. PMID:21816600

  2. 75 FR 18778 - Safety Zone; Ocean City Air Show 2010, Atlantic Ocean, Ocean City, MD

    Science.gov (United States)

    2010-04-13

    ... public dockets in the January 17, 2008, issue of the Federal Register (73 FR 3316). Public Meeting We do... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Ocean City Air Show 2010, Atlantic Ocean, Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking. SUMMARY: The Coast...

  3. 33 CFR 334.140 - Chesapeake Bay; U.S. Army Proving Ground Reservation, Aberdeen, Md.

    Science.gov (United States)

    2010-07-01

    ....140 Chesapeake Bay; U.S. Army Proving Ground Reservation, Aberdeen, Md. (a) Restricted area defined. The following indicates the limits of the waters of or adjacent to the Aberdeen Proving Ground, Maryland, and inside of which boundaries will lie the restricted area known as the Aberdeen Proving...

  4. 78 FR 60238 - Proposed Modification and Establishment of Restricted Areas; Aberdeen Proving Ground, MD

    Science.gov (United States)

    2013-10-01

    ...; Aberdeen Proving Ground, MD AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed..., within the existing restricted areas R-4001A and R- 4001B, at the U.S. Army's Aberdeen Proving Ground in... nonparticipating aircraft from a hazard to navigation in the Aberdeen Proving Ground airspace. DATES: Comments......

  5. 77 FR 3118 - Security Zone; Choptank River and Cambridge Channel, Cambridge, MD

    Science.gov (United States)

    2012-01-23

    ... 3118-3121] [FR Doc No: 2012-1172] DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 165 [Docket No. USCG-2011-1164] RIN 1625-AA87 Security Zone; Choptank River and Cambridge Channel, Cambridge, MD..., U.S. Coast Guard, Captain of the Port Baltimore. [FR Doc. 2012-1172 Filed 1-20-12; 8:45 am]...

  6. Identification of key residues that confer Rhodobacter sphaeroides LPS activity at horse TLR4/MD-2.

    Directory of Open Access Journals (Sweden)

    Katherine L Irvine

    Full Text Available The molecular determinants underpinning how hexaacylated lipid A and tetraacylated precursor lipid IVa activate Toll-like receptor 4 (TLR4 are well understood, but how activation is induced by other lipid A species is less clear. Species specificity studies have clarified how TLR4/MD-2 recognises different lipid A structures, for example tetraacylated lipid IVa requires direct electrostatic interactions for agonism. In this study, we examine how pentaacylated lipopolysaccharide from Rhodobacter sphaeroides (RSLPS antagonises human TLR4/MD-2 and activates the horse receptor complex using a computational approach and cross-species mutagenesis. At a functional level, we show that RSLPS is a partial agonist at horse TLR4/MD-2 with greater efficacy than lipid IVa. These data suggest the importance of the additional acyl chain in RSLPS signalling. Based on docking analysis, we propose a model for positioning of the RSLPS lipid A moiety (RSLA within the MD-2 cavity at the TLR4 dimer interface, which allows activity at the horse receptor complex. As for lipid IVa, RSLPS agonism requires species-specific contacts with MD-2 and TLR4, but the R2 chain of RSLA protrudes from the MD-2 pocket to contact the TLR4 dimer in the vicinity of proline 442. Our model explains why RSLPS is only partially dependent on horse TLR4 residue R385, unlike lipid IVa. Mutagenesis of proline 442 into a serine residue, as found in human TLR4, uncovers the importance of this site in RSLPS signalling; horse TLR4 R385G/P442S double mutation completely abolishes RSLPS activity without its counterpart, human TLR4 G384R/S441P, being able to restore it. Our data highlight the importance of subtle changes in ligand positioning, and suggest that TLR4 and MD-2 residues that may not participate directly in ligand binding can determine the signalling outcome of a given ligand. This indicates a cooperative binding mechanism within the receptor complex, which is becoming increasingly

  7. 基于C#技术的MD5加密算法设计与实现%Design and Implementation of MD5 Algorithm Based on C# Technology

    Institute of Scientific and Technical Information of China (English)

    王倩丽

    2010-01-01

    本文对Message-Digest Algorithm 5(信息-摘要算法)进行了简要描述,并对MD5算法的原理进行了深入分析.同时采用目前流行的C#语言对MD5算法进行了具体的应用,实现了MD5加密演示系统.虽然MD5算法因王小云教授在2004国际密码学会议上发表的论文引起了很大的反响,但MD5算法仍然在数字签名、电子商务、信息加密等领域中有着非常广泛的应用.

  8. Characterizing a point mutation within the UL5 gene that reduces in vivo replication and MD incidence

    Science.gov (United States)

    Marek’s disease virus (MDV) is an oncogenic alphaherpesvirus of chickens and the causative agent for Marek’s disease (MD). Vaccination is the primary method to control MD. Despite the success of vaccination, more virulent field strains are evolving, requiring the development of new vaccines. Attenua...

  9. 77 FR 9228 - AP Gas & Electric (MD), LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

    Science.gov (United States)

    2012-02-16

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission AP Gas & Electric (MD), LLC; Supplemental Notice That Initial Market-Based... above-referenced proceeding of AP Gas & Electric (MD), LLC's application for market-based rate...

  10. 33 CFR 165.556 - Regulated Navigation Area; Chesapeake and Delaware Canal, Chesapeake City Anchorage Basin, MD.

    Science.gov (United States)

    2010-07-01

    ... areas, found in 33 CFR 165.13, apply to the regulated navigation area described in paragraph (a) of this...; Chesapeake and Delaware Canal, Chesapeake City Anchorage Basin, MD. 165.556 Section 165.556 Navigation and..., Chesapeake City Anchorage Basin, MD. (a) Location. The following area is a regulated navigation area:...

  11. 33 CFR 334.170 - Chesapeake Bay, in the vicinity of Chesapeake Beach, Md.; firing range, Naval Research Laboratory.

    Science.gov (United States)

    2010-07-01

    ... of Chesapeake Beach, Md.; firing range, Naval Research Laboratory. 334.170 Section 334.170 Navigation... RESTRICTED AREA REGULATIONS § 334.170 Chesapeake Bay, in the vicinity of Chesapeake Beach, Md.; firing range... on the west by the shore of Chesapeake Bay. (2) Area B. The sector of a circle bounded by radii of...

  12. DMPD: Innate recognition of lipopolysaccharide by Toll-like receptor 4-MD-2. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 15051069 Innate recognition of lipopolysaccharide by Toll-like receptor 4-MD-2. Miy...ake K. Trends Microbiol. 2004 Apr;12(4):186-92. (.png) (.svg) (.html) (.csml) Show Innate recognition of lipopol...ysaccharide by Toll-like receptor 4-MD-2. PubmedID 15051069 Title Innate recognition of lipopolysacchari

  13. The Convergence of Business and Medicine: A Study of MD/MBA Programs in the United States

    Science.gov (United States)

    Keogh, Timothy J.; Martin, William Marty

    2011-01-01

    The purpose of this paper is to identify the convergence of business and medical education and describe the curricula of MD/MBA (Medical Doctor/Master of Business Administration) programs in the US. The focus of this study is to provide a guide to dual MD/MBA programs for physicians, aspiring physicians, policy makers and healthcare organizations.…

  14. Research of incremental extraction based on MD5 and HASH algorithm%融入MD5的HASH线性获取增量算法研究

    Institute of Scientific and Technical Information of China (English)

    郭亮; 杨金民

    2014-01-01

    To achieve rapid incremental extraction of database, an algorithm which is blended MD5 in HASH linear scan-ning to obtain increment is put forward based on analyzing the traditional incremental extraction. Each record in database can be seen as a character string and it can be generated into hash table as duplicate record, which is explored in hash table through traditional record to obtain increment and decrease frequency of comparison. Meanwhile, the fingerprint of each record can be generated with using MD5 algorithm, which reduces the length of character string in every HASH algorithm and comparison and improves efficiency. This algorithm is applicably tested in ORACLE database and the result shows that it is improved on calculative efficiency at a large extent compared with traditional algorithm.%为了实现数据库中的快速增量提取,在剖析传统的增量提取方法上,提出了一种融入MD5的HASH线性扫描来获取增量的算法。数据库中的每条记录都可视为一个字符串,利用HASH算法生成备份记录的散列表,通过原始记录去散列表中探测来达到线性扫描就能获取增量的目的,减少了比对次数;同时利用MD5算法生成每条记录的“指纹”,降低了每次HASH运算和比对的字符串长度,提高了效率。对所提出算法在ORACLE数据库上进行了应用测试,结果表明该算法效率较传统方法有很大提高。

  15. MD5 Encryption Algorithm and its Application in NETPRO Protocol%MD5加密算法及其在NETPRO协议中的应用

    Institute of Scientific and Technical Information of China (English)

    王大志; 马良

    2005-01-01

    短信网关系统中,内容提供商与网关之间通信采用客户机/服务器(C/S)模式,网关通过NETPRO协议与内容提供商通信.网络安全问题变得非常突出,对于用户密码等敏感信息,应该有一种能有效防止被轻易截获的方法来保护.MD5加密算法就是这种设想的强有力的工具.

  16. MdMYB1 Regulates Anthocyanin and Malate Accumulation by Directly Facilitating Their Transport into Vacuoles in Apples.

    Science.gov (United States)

    Hu, Da-Gang; Sun, Cui-Hui; Ma, Qi-Jun; You, Chun-Xiang; Cheng, Lailiang; Hao, Yu-Jin

    2016-03-01

    Tonoplast transporters, including proton pumps and secondary transporters, are essential for plant cell function and for quality formation of fleshy fruits and ornamentals. Vacuolar transport of anthocyanins, malate, and other metabolites is directly or indirectly dependent on the H(+)-pumping activities of vacuolar H(+)-ATPase (VHA) and/or vacuolar H(+)-pyrophosphatase, but how these proton pumps are regulated in modulating vacuolar transport is largely unknown. Here, we report a transcription factor, MdMYB1, in apples that binds to the promoters of two genes encoding the B subunits of VHA, MdVHA-B1 and MdVHA-B2, to transcriptionally activate its expression, thereby enhancing VHA activity. A series of transgenic analyses in apples demonstrates that MdMYB1/10 controls cell pH and anthocyanin accumulation partially by regulating MdVHA-B1 and MdVHA-B2. Furthermore, several other direct target genes of MdMYB10 are identified, including MdVHA-E2, MdVHP1, MdMATE-LIKE1, and MdtDT, which are involved in H(+)-pumping or in the transport of anthocyanins and malates into vacuoles. Finally, we show that the mechanism by which MYB controls malate and anthocyanin accumulation in apples also operates in Arabidopsis (Arabidopsis thaliana). These findings provide novel insights into how MYB transcription factors directly modulate the vacuolar transport system in addition to anthocyanin biosynthesis, consequently controlling organ coloration and cell pH in plants. PMID:26637549

  17. MD5算法在档案管理系统中的应用%Application of MD5 Algorithm in File Management System

    Institute of Scientific and Technical Information of China (English)

    徐宝清; 赵乾宗

    2015-01-01

    along with the country to the information development and the culture education the increasing attention, the file man⁃agement system is becoming more and more popular. At the same time, with the increase of the amount of archives and the amount of users, the file management system is developing towards more automatic and humane direction.. In order to make the system more accord with the safety standards, the system will use MD5 encryption algorithm for user identity authentication.%随着国家对信息化发展和文化教育的日益重视,档案管理系统正变得越来越普及。与此同时,伴随着档案量和用户量的不断增加,档案管理系统也向着更加自动化和人性化的方向发展。为了使系统更加符合安全标准,系统将采用MD5加密算法对用户身份进行有效认证。

  18. Moving Beyond Active-Site Detection: MixMD Applied to Allosteric Systems.

    Science.gov (United States)

    Ghanakota, Phani; Carlson, Heather A

    2016-08-25

    Mixed-solvent molecular dynamics (MixMD) is a hotspot-mapping technique that relies on molecular dynamics simulations of proteins in binary solvent mixtures. Previous work on MixMD has established the technique's effectiveness in capturing binding sites of small organic compounds. In this work, we show that MixMD can identify both competitive and allosteric sites on proteins. The MixMD approach embraces full protein flexibility and allows competition between solvent probes and water. Sites preferentially mapped by probe molecules are more likely to be binding hotspots. There are two important requirements for the identification of ligand-binding hotspots: (1) hotspots must be mapped at very high signal-to-noise ratio and (2) the hotspots must be mapped by multiple probe types. We have developed our mapping protocol around acetonitrile, isopropanol, and pyrimidine as probe solvents because they allowed us to capture hydrophilic, hydrophobic, hydrogen-bonding, and aromatic interactions. Charged probes were needed for mapping one target, and we introduce them in this work. In order to demonstrate the robust nature and wide applicability of the technique, a combined total of 5 μs of MixMD was applied across several protein targets known to exhibit allosteric modulation. Most notably, all the protein crystal structures used to initiate our simulations had no allosteric ligands bound, so there was no preorganization of the sites to predispose the simulations to find the allosteric hotspots. The protein test cases were ABL Kinase, Androgen Receptor, CHK1 Kinase, Glucokinase, PDK1 Kinase, Farnesyl Pyrophosphate Synthase, and Protein-Tyrosine Phosphatase 1B. The success of the technique is demonstrated by the fact that the top-four sites solely map the competitive and allosteric sites. Lower-ranked sites consistently map other biologically relevant sites, multimerization interfaces, or crystal-packing interfaces. Lastly, we highlight the importance of including protein

  19. PoopMD, a Mobile Health Application, Accurately Identifies Infant Acholic Stools.

    Directory of Open Access Journals (Sweden)

    Amy Franciscovich

    Full Text Available Biliary atresia (BA is the leading cause of pediatric end-stage liver disease in the United States. Education of parents in the perinatal period with stool cards depicting acholic and normal stools has been associated with improved time-to-diagnosis and survival in BA. PoopMD is a mobile application that utilizes a smartphone's camera and color recognition software to analyze an infant's stool and determine if additional follow-up is indicated. PoopMD was developed using custom HTML5/CSS3 and wrapped to work on iOS and Android platforms. In order to define the gold standard regarding stool color, seven pediatricians were asked to review 45 photographs of infant stool and rate them as acholic, normal, or indeterminate. Samples for which 6+ pediatricians demonstrated agreement defined the gold standard, and only these samples were included in the analysis. Accuracy of PoopMD was assessed using an iPhone 5s with incandescent lighting. Variability in analysis of stool photographs as acholic versus normal with intermediate rating weighted as 50% agreement (kappa was compared between three laypeople and one expert user. Variability in output was also assessed between an iPhone 5s and a Samsung Galaxy S4, as well as between incandescent lighting and compact fluorescent lighting. Six-plus pediatricians agreed on 27 normal and 7 acholic photographs; no photographs were defined as indeterminate. The sensitivity was 7/7 (100%. The specificity was 24/27 (89% with 3/27 labeled as indeterminate; no photos of normal stool were labeled as acholic. The Laplace-smoothed positive likelihood ratio was 6.44 (95% CI 2.52 to 16.48 and the negative likelihood ratio was 0.13 (95% CI 0.02 to 0.83. kappauser was 0.68, kappaphone was 0.88, and kappalight was 0.81. Therefore, in this pilot study, PoopMD accurately differentiates acholic from normal color with substantial agreement across users, and almost perfect agreement across two popular smartphones and ambient light

  20. PoopMD, a Mobile Health Application, Accurately Identifies Infant Acholic Stools.

    Science.gov (United States)

    Franciscovich, Amy; Vaidya, Dhananjay; Doyle, Joe; Bolinger, Josh; Capdevila, Montserrat; Rice, Marcus; Hancock, Leslie; Mahr, Tanya; Mogul, Douglas B

    2015-01-01

    Biliary atresia (BA) is the leading cause of pediatric end-stage liver disease in the United States. Education of parents in the perinatal period with stool cards depicting acholic and normal stools has been associated with improved time-to-diagnosis and survival in BA. PoopMD is a mobile application that utilizes a smartphone's camera and color recognition software to analyze an infant's stool and determine if additional follow-up is indicated. PoopMD was developed using custom HTML5/CSS3 and wrapped to work on iOS and Android platforms. In order to define the gold standard regarding stool color, seven pediatricians were asked to review 45 photographs of infant stool and rate them as acholic, normal, or indeterminate. Samples for which 6+ pediatricians demonstrated agreement defined the gold standard, and only these samples were included in the analysis. Accuracy of PoopMD was assessed using an iPhone 5s with incandescent lighting. Variability in analysis of stool photographs as acholic versus normal with intermediate rating weighted as 50% agreement (kappa) was compared between three laypeople and one expert user. Variability in output was also assessed between an iPhone 5s and a Samsung Galaxy S4, as well as between incandescent lighting and compact fluorescent lighting. Six-plus pediatricians agreed on 27 normal and 7 acholic photographs; no photographs were defined as indeterminate. The sensitivity was 7/7 (100%). The specificity was 24/27 (89%) with 3/27 labeled as indeterminate; no photos of normal stool were labeled as acholic. The Laplace-smoothed positive likelihood ratio was 6.44 (95% CI 2.52 to 16.48) and the negative likelihood ratio was 0.13 (95% CI 0.02 to 0.83). kappauser was 0.68, kappaphone was 0.88, and kappalight was 0.81. Therefore, in this pilot study, PoopMD accurately differentiates acholic from normal color with substantial agreement across users, and almost perfect agreement across two popular smartphones and ambient light settings. PoopMD

  1. Java安全包的MD5防穷举变换算法的研究与实现%Research and Implementation of MD5 Anti-exhaustive Algrithm based on Java Security Package

    Institute of Scientific and Technical Information of China (English)

    傅旭光

    2009-01-01

    分析了MD5加密算法和碰撞的原理,对目前常规MD5算法加密结果容易被破解的问题,利用JDK的java.security包中的MD5算法给出了JavaBeans形式的变换算法,以期进一步减小破解时碰撞的概率,增强系统加密的安全性.

  2. Vacuum Structure of Twisted Scalar Field Theories on $M^{D-1} \\otimes S^{1}$

    CERN Document Server

    Hatanaka, H; Ohnishi, K; Sakamoto, M

    2001-01-01

    We study scalar field theories on M^{D-1} \\otimes S^1, which allow to impose twisted boundary conditions for the S^1 direction, in detail and report several interesting properties overlooked so far. One of characteristic features is the appearance of critical radii of the circle S^1. A phase transition can occur at the classical level or can be caused by quantum effects. Radiative corrections can restore broken symmetries or can break symmetries for small radius. A surprising feature is that the translational invariance for the S^1 direction can spontaneously be broken. A particular class of coordinate-dependent vacuum configurations is clarified and the O(N) \\phi^4 model on M^{D-1}\\otimes S^1 is extensively studied, as an illustrative example.

  3. Role of Calcium Ion in Apoptosis of MD Cancer Cells Induced by Arsenic Trioxide

    Institute of Scientific and Technical Information of China (English)

    ZHANG Jiuli; WANG Jintao; XU Shiwen

    2008-01-01

    In order to observe the role of calcium ion in apoptosis of MD cancer cells induced by arsenic trioxide, inhibition percentage was detected by MTT assay;morphology changes were examined by fluorescence microscope;apoptosis was examined by DNA Ladder;[Ca2+]i was investigated by spectrofluorimeter in vitro on MDCC-MSB1 cells. The results showed that As2O3 inhibited the proliferation of MDCC-MSB1 cells in concentration dependent manner (P<0.05 or P<0.01);typical apoptosis character was observed by fluorescence microscope;DNA Ladder was observed;the [Ca2+]i was elevated significantly after the treatment of As203 (P<0.05 or P<0.01) and showed a dose-dependent manner. It is concluded that the calcium may play an important role in apoptosis of MD cancer cells induced by arsenic trioxide.

  4. A Compact Starburst Core in the Dusty Lyman Break Galaxy Westphal-MD11

    CERN Document Server

    Baker, A J; Lehnert, M D; Lutz, D; Tacconi, L J; Baker, Andrew J.; Tacconi, Linda J.; Genzel, Reinhard; Lutz, Dieter

    2004-01-01

    Using the IRAM Plateau de Bure Interferometer, we have searched for CO(3-2) emission from the dusty Lyman break galaxy Westphal-MD11 at z = 2.98. Our sensitive upper limit is surprisingly low relative to the system's 850 um flux density and implies a far-IR/CO luminosity ratio as elevated as those seen in local ultraluminous mergers. We conclude that the observed dust emission must originate in a compact structure radiating near its blackbody limit and that a relatively modest molecular gas reservoir must be fuelling an intense nuclear starburst (and/or deeply buried active nucleus) that may have been triggered by a major merger. In this regard, Westphal-MD11 contrasts strikingly with the lensed Lyman break galaxy MS1512-cB58, which is being observed apparently midway through an extended episode of more quiescent disk star formation.

  5. Molecular dynamics (MD) calculation of the real zeta potential of neutral surfaces

    CERN Document Server

    Liu, Hongyi

    2013-01-01

    Molecular dynamics (MD) simulations of the zeta potential are so poor that it has become common to term their predictions "apparent". Here we demonstrate how MD methods can predict zeta potentials accurate enough they can be termed "real". The critical new aspects of our method are: (1) integrating the net average charge in surface-parallel layers from the midpoint of the fluid layer (where the electrostatic potential is zero) to and then into two solid caps, (2) determining the position of slipping plane with separate Couette flow models, and (3) calculating the charge distribution and electrostatic potential under static conditions. The solids are charge neutral surfaces composed of atoms with zero charge or charge balanced monovalent or divalent ions. The zeta potentials calculated are within a few millivolts of measured values, and the measured values fall within the simulation error bars. The zeta potentials calculated with the Helmholtz and Smoluchowski equation following current practice are 10's of mi...

  6. A virtual observatory for photoionized nebulae: the Mexican Million Models database (3MdB)

    CERN Document Server

    Morisset, Christophe; Flores-Fajardo, Nahiely

    2014-01-01

    Photoionization models obtained with numerical codes are widely used to study the physics of the interstellar medium (Planetary Nebulae, H II regions, etc). Grid of models are performed to understand what are the effects of the different parameters used to describe the regions on the observables (mainly emission line intensities). Most of the time, only a small part of the computed results of such grids are published, and they are sometimes hard to obtain in a user-friendly format. We present here the Mexican Million Models dataBase (3MdB), an effort of resolving both of these issues in the form of a database of photoionization models, easily accessible throught the MySQL protocol, and containing a lot of usefull outputs from the models, such as the intensities of 178 emission lines, the ionic fractions of all the ions, etc. Some examples of the use of the 3MdB are also presented.

  7. An assessment of communication skills of the MD/MS students of institute of medicine in Nepal

    Directory of Open Access Journals (Sweden)

    Jagdish Prasad Agrawal

    2013-09-01

    Full Text Available Introduction The main objective of this study was to assess the level of interpersonal communication skills of MD/MS resident doctors and to provide recommendations for the future. Methods Descriptive, cross sectional, qualitative and quantitative research design was used. 7- point Likert scale (0 to 6 MAAS-Global scoring instrument was used. The subjects of the research were the MD/MS residents from various departments of Maharajgunj Medical Campus (MMC of Institute of Medicine, Maharajgunj, Kathmandu. Out of 162 MD/MS residents, only 30 (18.5% MD/MS residents were selected for the sample size for the study from 1st, 2nd and 3rd year. One MD/MS resident was required four video recording to conduct four interviews with patients coming to the outpatient department. Results There was high degree of positive correlation between Information sharing and Management (r=0.746 whereas weak negative correlation on clarification and diagnosis (r=-0.011. Inter-rater correlation was established before hand and was satisfactory (p < 0.05. Conclusions This base line study of MD/MS residents shows that over all MD/MS residents are deficient in almost all the components of interpersonal communication skills. A communication skills training course in postgraduate medical education could improve the existing communication skills of the doctors in Nepal.

  8. Comparison of the SIMARD MD to Clinical Impression in Assessing Fitness to Drive in Patients with Cognitive Impairment

    Science.gov (United States)

    Wernham, Madelaine; Jarrett, Pamela G.; Stewart, Connie; MacDonald, Elizabeth; MacNeil, Donna; Hobbs, Cynthia

    2014-01-01

    Background The assessment of fitness to drive in patients with cognitive impairment is complex. The SIMARD MD was developed to assist with assessing fitness to drive. This study compares the clinical decision made by a geriatrician regarding driving with the SIMARD MD score. Methods Patients with a diagnosis of mild dementia or mild cognitive impairment, who had a SIMARD MD test, were included in the sample. A retrospective chart review was completed to gather diagnosis, driving status, and cognitive and functional information. Results Sixty-three patients were identified and 57 met the inclusion criteria. The mean age was 77.1 years (SD 8.9). The most common diagnosis was Alzheimer’s disease in 22 (38.6%) patients. The mean MMSE score was 24.9 (SD 3.34) and the mean MoCA was 19.9 (SD 3.58). The mean SIMARD MD score was 37.2 (SD 19.54). Twenty-four patients had a SIMARD MD score ≤ 30, twenty-eight between 31–70, and five scored > 70. The SIMARD MD scores did not differ significantly compared to the clinical decision (ANOVA p value = 0.14). Conclusions There was no association between the SIMARD MD scores and the geriatricians’ clinical decision regarding fitness to drive in persons with mild dementia or mild cognitive impairment. PMID:24883164

  9. Hybrid Pressure Retarded Osmosis−Membrane Distillation (PRO−MD) Process for Osmotic Power and Clean Water Generation

    KAUST Repository

    Han, Gang

    2015-05-20

    A novel pressure retarded osmosis−membrane distillation (PRO−MD) hybrid process has been experimentally conceived for sustainable production of renewable osmotic power and clean water from various waters. The proposed PRO−MD system may possess unique advantages of high water recovery rate, huge osmotic power generation, well controlled membrane fouling, and minimal environmental impacts. Experimental results show that the PRO−MD hybrid process is promising that not only can harvest osmotic energy from freshwater but also from wastewater. When employing a 2 M NaCl MD concentrate as the draw solution, ultrahigh power densities of 31.0 W/m2 and 9.3 W/m2 have been demonstrated by the PRO subsystem using deionized water and real wastewater brine as the feeds, respectively. Simultaneously, high purity potable water with a flux of 32.5−63.1 L/(m2.h) can be produced by the MD subsystem at 40−60 °C without any detrimental effects of fouling. The energy consumption in the MD subsystem might be further reduced by applying a heat exchanger in the hybrid system and using low-grade heat or solar energy to heat up the feed solution. The newly developed PRO−MD hybrid process would provide insightful guidelines for the exploration of alternative green technologies for renewable osmotic energy and clean water production.

  10. Human microbiome science: vision for the future, Bethesda, MD, July 24 to 26, 2013

    OpenAIRE

    Ravel, Jacques; Mazmanian, Sarkis K.

    2014-01-01

    A conference entitled ‘Human microbiome science: Vision for the future’ was organized in Bethesda, MD from July 24 to 26, 2013. The event brought together experts in the field of human microbiome research and aimed at providing a comprehensive overview of the state of microbiome research, but more importantly to identify and discuss gaps, challenges and opportunities in this nascent field. This report summarizes the presentations but also describes what is needed for human microbiome research...

  11. The path ahead for MD/PhD programs in Canada Commentary on Jones et al.

    Science.gov (United States)

    Rosenblum, Norman D

    2016-01-01

    The paper by Jones and colleagues, published in this edition of Clinical Investigative Medicine, contributes to our understanding of Canadian MD/PhD Programs. While there has been little published on this subject by the Canadian programs, themselves, this paper is the most recent in a series by leaders of the Clinical Investigator Trainee Association of Canada (CITAC). The authors are to be commended for their efforts and productivity. PMID:27619401

  12. Molecular Dynamics/Order Parameter eXtrapolation (MD/OPX) for Bionanosystem Simulations

    OpenAIRE

    Miao, Yinglong; Ortoleva, Peter J.

    2009-01-01

    A multiscale approach, Molecular Dynamics/Order Parameter eXtrapolation (MD/OPX), to the all-atom simulation of large bionanosystems is presented. The approach starts with the introduction of a set of order parameters (OPs) automatically generated with orthogonal polynomials to characterize the nanoscale features of bionanosystems. The OPs are shown to evolve slowly via Newton’s equations and the all-atom multiscale analysis (AMA) developed earlier1 demonstrates the existence of their stochas...

  13. A unified architecture of MD5 and RIPEMD-160 hash algorithms

    OpenAIRE

    Ng, CW; Ng, TS; Yip, KW

    2004-01-01

    Hash algorithms are important components in many cryptographic applications and security protocol suites. In this paper, a unified architecture for MD5 and RIPEMD-160 hash algorithms is developed. These two algorithms are different in speed and security level. Therefore, a unified hardware design allows applications to switch from one algorithm to another based on different requirements. The architecture has been implemented using Altera's EPF10K50SBC356-1, providing a throughput over 200Mbit...

  14. An Efficient Hybrid DSMC/MD Algorithm for Accurate Modeling of Micro Gas Flows

    KAUST Repository

    Liang, Tengfei

    2013-01-01

    Aiming at simulating micro gas flows with accurate boundary conditions, an efficient hybrid algorithmis developed by combining themolecular dynamics (MD) method with the direct simulationMonte Carlo (DSMC)method. The efficiency comes from the fact that theMD method is applied only within the gas-wall interaction layer, characterized by the cut-off distance of the gas-solid interaction potential, to resolve accurately the gas-wall interaction process, while the DSMC method is employed in the remaining portion of the flow field to efficiently simulate rarefied gas transport outside the gas-wall interaction layer. A unique feature about the present scheme is that the coupling between the two methods is realized by matching the molecular velocity distribution function at the DSMC/MD interface, hence there is no need for one-toone mapping between a MD gas molecule and a DSMC simulation particle. Further improvement in efficiency is achieved by taking advantage of gas rarefaction inside the gas-wall interaction layer and by employing the "smart-wall model" proposed by Barisik et al. The developed hybrid algorithm is validated on two classical benchmarks namely 1-D Fourier thermal problem and Couette shear flow problem. Both the accuracy and efficiency of the hybrid algorithm are discussed. As an application, the hybrid algorithm is employed to simulate thermal transpiration coefficient in the free-molecule regime for a system with atomically smooth surface. Result is utilized to validate the coefficients calculated from the pure DSMC simulation with Maxwell and Cercignani-Lampis gas-wall interaction models. ©c 2014 Global-Science Press.

  15. MD/MBA Students: An Analysis of Medical Student Career Choice

    OpenAIRE

    Sherrill, Windsor Westbrook

    2009-01-01

    Background: An increasing number of medical schools are offering dual degree MD/MBA programs. Career choices and factors influencing students to enter these programs provide an indicator of the roles in which dual degree students will serve in health care as well as the future of dual degree programs. Purpose: Using career choice theory as a conceptual framework, career goals and factors influencing decisions to enter dual degree programs were assessed among dual degree medical students. Me...

  16. ExTASY: Scalable and Flexible Coupling of MD Simulations and Advanced Sampling Techniques

    OpenAIRE

    Balasubramanian, Vivekanandan; Bethune, Iain; Shkurti, Ardita; Breitmoser, Elena; Hruska, Eugen; Clementi, Cecilia; Laughton, Charles; Jha, Shantenu

    2016-01-01

    For many macromolecular systems the accurate sampling of the relevant regions on the potential energy surface cannot be obtained by a single, long Molecular Dynamics (MD) trajectory. New approaches are required to promote more efficient sampling. We present the design and implementation of the Extensible Toolkit for Advanced Sampling and analYsis (ExTASY) for building and executing advanced sampling workflows on HPC systems. ExTASY provides Python based "templated scripts" that interface to a...

  17. Measurement of the Mass Difference m(D_s^+) - m(D^+) at CDF II

    CERN Document Server

    Acosta, D; Ahn, M H; Akimoto, T; Albrow, M G; Alcorn, B; Alexander, C; Allen, D; Allspach, D H; Amaral, P; Ambrose, D; Amendolia, S R; Amidei, D; Amundson, J F; Anastassov, A; Anderson, J; Anikeev, K; Annovi, A; Antos, J; Aoki, M; Apollinari, G; Arguin, J F; Arisawa, T; Artikov, A; Asakawa, T; Ashmanskas, W; Attal, A; Avanzini, C; Azfar, F; Azzi-Bacchetta, P; Babik, M; Bacchetta, N; Bachacou, H; Badgett, W F; Bailey, S; Bakken, J; Barbaro-Galtieri, A; Bardi, A; Bari, M; Barker, G; Barnes, V E; Barnett, B A; Baroiant, S; Barone, M; Barsotti, E; Basti, A; Bauer, G; Beckner, D; Bedeschi, F; Behari, S; Belforte, S; Bell, W H; Bellendir, G; Bellettini, Giorgio; Bellinger, J; Benjamin, D; Beretvas, A; Berg, B; Bhatti, A A; Binkley, M; Bisello, D; Bishai, M; Blair, R E; Blocker, C; Bloom, K; Blumenfeld, B; Bocci, A; Bodek, A; Bogdan, M; Bölla, G; Bolshov, A; Booth, P S L; Bortoletto, Daniela; Boudreau, J; Bourov, S; Bowden, M; Box, D; Bromberg, C; Brown, W; Brozovic, M; Brubaker, E; Buckley-Geer, L; Budagov, Yu A; Budd, H S; Burkett, K; Busetto, G; Bussey, P; Byon-Wagner, A; Byrum, K L; Cabrera, S; Calafiura, P; Campanelli, M; Campbell, M; Canal, P; Canepa, A; Carithers, W C; Carlsmith, D; Carosi, R; Carrell, K; Carter, H; Caskey, W; Castro, A; Cauz, D; Cerri, A; Cerri, C; Cerrito, L; Chandler, J T; Chapman, J; Chappa, S; Chen, C; Chen, Y C; Cheng, M T; Chertok, M; Chiarelli, G; Chirikov-Zorin, I E; Chlachidze, G; Chlebana, F; Cho, I; Cho, K; Chokheli, D; Chu, M L; Chung, J Y; Chung, W H; Chung, Y S; Ciobanu, C I; Ciocci, M A; Cisko, S; Clark, A G; Coca, M; Coiley, K; Colijn, A P; Colombo, R M; Connolly, A; Convery, M; Conway, J; Cooper, G; Cordelli, M; Cortiana, G; Cranshaw, J; Cudzewicz, R; Culbertson, R; Currat, C; Cyr, D; Dagenhart, D; Dal Monte, L; Da Ronco, S; D'Auria, S; Davila, R; Dawson, J; Dawson, T; De Barbaro, P; De Baun, C; De Cecco, S; Dell'Agnello, S; Dell'Orso, Mauro; De Maat, R; Demar, P; Demers, S; Demortier, L; Deninno, M; De Pedis, D; Derwent, P F; Derylo, G; Devlin, T; Dionisi, C; Dittmann, J R; Doksus, P; Dominguez, A; Donati, S; Donno, F; D'Onofrio, M; Dorigo, T; Downing, R; Drake, G; Drennan, C; Drollinger, V; Dunietz, Isard; Dyer, A; Ebina, K; Eddy, N; Ely, R; Engels, E; Erbacher, R D; Erdmann, M; Errede, D; Errede, S; Eusebi, R; Fang, H C; Farrington, S; Feild, R G; Feindt, M; Fernández, J P; Ferretti, C; Field, R D; Fiori, I; Fischler, M; Flanagan, G; Flaugher, B; Flores-Castillo, L R; Foland, A D; Forrester, S; Foster, G W; Franklin, M; Frisch, H; Fromm, J; Fujii, Y; Furic, I; Galeotti, S; Galet, G; Gallas, A; Gallinaro, M; Ganel, O; García, C; García-Sciveres, M; Garfinkel, A F; Garwacki, M; Garzoglio, G; Gay, C; Gerberich, H; Gerdes, D W; Gerchtein, E; Gerstenslager, J; Giacchetti, L; Giagu, S; Giannetti, P; Gibson, A; Gillespie, G; Gingu, C; Ginsburg, C; Giolo, K; Giordani, M; Glagolev, V; Glenzinski, D A; Glossen, R; Gold, M; Goldschmidt, N; Goldstein, D B; Goldstein, J; Gómez, G; Goncharov, M; González, H; Gordon, S; Gorelov, I; Goshaw, A T; Gotra, Yu; Goulianos, K; Grado, J; Gregori, M; Gresele, A; Griffin, T; Grim, G; Grimm, C; Gromoll, S; Grosso-Pilcher, C; Gu, C; Guarino, V; Günther, M; Guimarães da Costa, J; Haber, C; Hahn, A; Hahn, K; Hahn, S R; Halkiadakis, E; Hall, C; Handler, R; Haney, M; Hao, W; Happacher, F; Hara, K; Hare, M; Harr, R F; Harrington, J; Harris, R M; Hartmann, F; Hatakeyama, K; Hauser, J; Hawke, T; Hays, C; Heider, E; Heinemann, B; Heinrich, J; Heiss, A; Hennecke, M; Herber, R; Herndon, M; Herren, M; Hicks, D; Hill, C; Hirschbuehl, D; Höcker, A; Hoff, J; Hoffman, K D; Hoftiezer, J H; Holloway, A; Holloway, L E; Holm, S; Holmgren, D; Hou, S; Houlden, M A; Howell, J; Hrycyk, M; Hubbard, P; Hughes, R E; Huffman, B T; Humbert, J; Huston, J; Ikado, K; Incandela, J R; Introzzi, G; Iori, M; Ishizawa, I; Issever, C; Ivanov, A; Iwata, Y; Iyutin, B; James, E; Jang, D; Jarrell, J; Jeans, D; Jensen, H; Jetton, R; Johnson, M; Jones, M; Jones, T; Jun, S Y; Junk, T R; Kallenbach, Jeff; Kamon, T; Kang, J; Karagoz-Unel, M; Karchin, P E; Kartal, S; Kasha, H; Kasten, M; Kato, Y; Kemp, Y; Kennedy, R D; Kephart, K; Kephart, R D; Khazins, D; Khotilovich, V; Kilminster, B; Kim, B J; Kim, D H; Kim, H S; Kim, J; Kim, M J; Kim, M S; Kim, S B; Kim, S H; Kim, T H; Kim, Y K; King, B T; Kirby, M; Kirk, M; Kirsch, L; Klein, R; Klimenko, S; Knapp, M; Knoblauch, D; Knuteson, B; Kobayashi, H; Koehn, P; Kondo, K; Kong, D J; Konigsberg, J; Kononenko, W; Kordas, K; Korn, A J; Korytov, A; Kotelnikov, K A; Kotwal, A; Kovalev, A; Kowalkowski, J B; Kraus, J; Kravchenko, I V; Kreymer, A; Kroll, J; Kruse, M; Krutelyov, V; Kuhlmann, S E; Kumar, A; Kuznetsova, N; Laasanen, A T; Lai, S; Lami, S; Lammel, S; Lamore, D; Lancaster, J; Lancaster, M; Lander, R; Lanfranco, G; Lannon, K; Lath, A; Latino, G; Lauhakangas, R; Lazzizzera, I; Le, Y; LeCompte, T J; Lee, J; Lee, K; Lee, S W; Lei, C M; Leininger, M; Leonardi, G L; Leonardo, N; Leone, S; Levshina, T; Lewis, F; Lewis, J D; Li, K; Lin, C S; Lindgren, M; Liss, T M; Litvintsev, D O; Liu, T; Liu, Y; Lobban, O; Lockyer, N S; Loginov, A; Loken, J; Loreti, M; Loskot, J; Loverre, P F; Lucchesi, D; Lukens, P; Lutz, P; Lyons, L; Lys, J; MacNerland, J; MacQueen, D; Madorsky, A; Madrak, R; Maeshima, K; Maksimovic, P; Malferrari, L; Mammini, P; Manca, G; Mandrichenko, I V; Manea, C; Marginean, R; Marrafino, J; Martin, A; Martin, M; Martin, V; Martínez, M; Maruyama, T; Matsunaga, H; Mayer, J; Mayers, G M; Mazzanti, P; McFarland, K S; McGivern, D; McIntyre, P M; McNamara, P; McNulty, R; Menzemer, S; Menzione, A; Merkel, P; Mesropian, C; Messina, A; Meyer, A; Miao, T; Michael, N; Miller, J S; Miller, L; Miller, R; Miquel, R; Miscetti, S; Mitselmakher, G; Miyamoto, A; Miyazaki, Y; Mizicko, D; Moccia, S; Moggi, A; Moggi, N; Montero, S; Moore, R; Moore, T; Morris, L; Morsani, F; Moulik, T; Mukherjee, A; Mulhearn, M; Müller, T; Mumford, R; Munar, A; Murat, P; Murgia, S; Nachtman, J; Nagaslaev, V; Nahn, S; Nakamura, I; Nakano, I; Napier, A; Napora, R; Necula, V; Nelson, C; Nelson, T; Neu, C; Neubauer, M S; Neuberger, D; Newby, W; Newcomer, F M; Newman-Holmes, C; Niell, F; Nielsen, J; Nicollerat, A S; Nigmanov, T; Niu, H; Nodulman, L; Noe, W; Österberg, K; Ogawa, T; Oh, S; Oh, Y D; Ohl, K; Ohsugi, T; Oishi, R; Okusawa, T; Oldeman, R G C; Orava, Risto; Orejudos, W; Orr, S; Pagani, G; Pagliarone, C; Palmonari, F; Ramos, I; Panacek, S; Pantano, D; Paoletti, R; Papadimitriou, V; Pasetes, R; Pashapour, S; Passuello, D; Paterno, M; Patrick, J; Pauletta, G; Paulini, M; Pauly, T; Paus, C; Pavlicek, V; Pavlon, S; Pellett, D; Penzo, Aldo L; Perington, B; Petragnani, G; Petravick, D; Phillips, T J; Photos, F; Piacentino, G; Picciolo, C; Piccoli, L; Piedra, J; Pitts, K T; Plunkett, R; Pompos, A; Pondrom, L; Pope, G; Poukhov, O; Prakoshyn, F; Pratt, T; Profeti, A; Pronko, A G; Proudfoot, J; Punzi, G; Rademacker, J; Rafaelli, F; Rakitine, A; Rappoccio, S; Ratnikov, F; Rauch, J; Ray, H; Rechenmacher, R; Reia, S; Reichold, A; Rekovic, V; Renton, P B; Rescigno, M; Rimondi, F; Rinnert, K; Ristori, L; Riveline, M; Rivetta, C; Robertson, W J; Robson, A; Rodrigo, T; Rolli, S; Román, M; Rosenberg, S I; Rosenson, L; Roser, R; Rossin, R; Rott, C; Ruiz, A; Russ, J; Ryan, D; Saarikko, H; Sabik, S; Sadler, L; Safonov, A; Saint-Denis, R; Sakumoto, W K; Saltzberg, D; Sánchez, C; Sanders, H; Sanders, R; Sandrew, M; Sansoni, A; Santi, L; Sarkar, S; Sarraj, H; Sarraj, J; Sato, H; Savard, P; Schemitz, P; Schlabach, P; Schmidt, E E; Schmidt, J; Schmidt, M P; Schmitt, M; Schmitt, R; Schmitz, M; Schofield, G L; Schuh, K; Schultz, K; Scodellaro, L; Scott, L; Scribano, A; Scuri, F; Sedov, A; Segler, S; Seidel, S; Seiya, Y; Semenov, A; Semeria, F; Sexton-Kennedy, L; Sfiligoi, I; Shallenberger, J; Shapiro, M D; Shaw, T; Shears, T G; Shenai, A; Shepard, P F; Shimojima, M; Shochet, M J; Shon, Y; Shoun, M; Sidoti, A; Siegrist, J L; Sieh, C; Siket, M; Sill, A; Silva, R; Simaitis, V; Sinervo, P; Sirotenko, V I; Sissakian, A N; Skiba, A; Slaughter, A J; Sliwa, K; Smith, J; Snider, F D; Snihur, R; Somalwar, S V; Spalding, J; Spezziga, M; Spiegel, L; Spinella, F; Spiropulu, M; Stadie, H; Stanek, R; Stanfield, N; Stelzer, B; Stelzer-Chilton, O; Strologas, J; Stuart, D; Stuermer, W; Sukhanov, A; Sumorok, K; Sun, H; Suzuki, T; Syu, J; Szymulanski, A; Taffard, A C; Takach, S F; Takano, H; Takashima, R; Takeuchi, Y; Takikawa, K; Tamburello, P; Tanaka, M; Tanaka, R; Tang, D; Tanimoto, N; Tannenbaum, B; Tapprogge, Stefan; Taylor, R D; Teafoe, G; Tecchio, M; Teng, P K; Terashi, K; Terentieva, T; Tesarek, R J; Tether, S; Thom, J; Thomas, A; Thompson, A S; Thomson, E; Thurman-Keup, R M; Timm, S; Tipton, P; Tkaczyk, S M; Toback, D; Tollefson, K; Tonelli, D; Tonnesmann, M; Torretta, D; Trimby, C; Trischuk, W; Trumbo, J; Tseng, J; Tsuchiya, R; Tsuno, S; Tsybychev, D; Turini, N; Turner, M; Ukegawa, F; Unverhau, T; Uozumi, S; Usynin, D; Vacavant, L; Vaiciulis, T; Van Berg, R; Varganov, A V; Vataga, E; Vejcik, S; Velev, G V; Veramendi, G; Vickey, T; Vidal, R; Vila, I; Vilar, R; Vittone, M; Voirin, J; Vollmer, B; Vollrath, I; Volobuev, I P; Von der Mey, M; Votava, M; Wagner, R G; Wagner, R L; Wagner, W; Wallace, N; Walter, T; Walters, A; Wan, Z; Wandersee, A; Wang, M J; Wang, S M; Ward, B; Waschke, S; Waters, D; Watts, T; Weber, M; Weems, L; Wenzel, H; Wester, W; Whitehouse, B; Wickenberg, W; Wicklund, A B; Wicklund, E; Wigmans, R; Wike, C; Wilkes, T; Williams, H H; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolter, M; Wong, M; Worcester, M; Worland, R; Worm, S; Wright, T; Wu, J; Wu, X; Würthwein, F; Wyatt, A; Yagil, A; Yamamoto, K; Yamashita, T; Yang, U K; Yao, W; Yarema, R J; Yeh, G P; Yi, K; Yocum, D R; Yoh, J K; Yoon, P; Yorita, K; Yoshida, T; Yu, I; Yu, S; Yu, Z; Yun, J C; Zalokar, M; Zanello, L; Zanetti, A; Zaw, I; Zetti, F; Zhou, J; Zimmerman, T; Zsenei, A; Zucchelli, S

    2003-01-01

    We present a measurement of the mass difference m(D+_s) - m(D+), where both the D+_s and D+ are reconstructed in the phi pi+ decay channel. This measurement uses 11.6 pb-1 of data collected by CDF II using the new displaced-track trigger. The mass difference is found to be: 99.41 +- 0.38 (stat) +- 0.21 (syst) MeV/c^2.

  18. The path ahead for MD/PhD programs in Canada Commentary on Jones et al.

    Science.gov (United States)

    Rosenblum, Norman D

    2016-09-11

    The paper by Jones and colleagues, published in this edition of Clinical Investigative Medicine, contributes to our understanding of Canadian MD/PhD Programs. While there has been little published on this subject by the Canadian programs, themselves, this paper is the most recent in a series by leaders of the Clinical Investigator Trainee Association of Canada (CITAC). The authors are to be commended for their efforts and productivity.

  19. mdRNA-Seq analysis of marine microbial communities from the northern Red Sea

    Science.gov (United States)

    Hou, Shengwei; Pfreundt, Ulrike; Miller, Dan; Berman-Frank, Ilana; Hess, Wolfgang R.

    2016-01-01

    Metatranscriptomic differential RNA-Seq (mdRNA-Seq) identifies the suite of active transcriptional start sites at single-nucleotide resolution through enrichment of primary transcript 5′ ends. Here we analyzed the microbial community at 45 m depth at Station A in the northern Gulf of Aqaba, Red Sea, during 500 m deep mixing in February 2012 using mdRNA-Seq and a parallel classical RNA-Seq approach. We identified promoters active in situ for five different pico-planktonic genera (the SAR11 clade of Alphaproteobacteria, Synechococcus of Cyanobacteria, Euryarchaeota, Thaumarchaeota, and Micromonas as an example for picoeukaryotic algae), showing the applicability of this approach to highly diverse microbial communities. 16S rDNA quantification revealed that 24% of the analyzed community were group II marine Euryarchaeota in which we identified a highly abundant non-coding RNA, Tan1, and detected very high expression of genes encoding intrinsically disordered proteins, as well as enzymes for the synthesis of specific B vitamins, extracellular peptidases, carbohydrate-active enzymes, and transport systems. These results highlight previously unknown functions of Euryarchaeota with community-wide relevance. The complementation of metatranscriptomic studies with mdRNA-Seq provides substantial additional information regarding transcriptional start sites, promoter activities, and the identification of non-coding RNAs. PMID:27759035

  20. Structural and Dynamic Analysis on IDPs by Modified AWSEM-MD

    Science.gov (United States)

    Wu, Hao; Papoian, Garegin; Papoian Theoretical Biophysics Group Team

    Unlike globular proteins, intrinsically disordered proteins (IDPs) lack both secondary and tertiary structures and can play key roles in various biological processes, including transcriptional regulation, molecular recognition and cellular signaling. These functions can be potentially elucidated by structural heterogeneity of IDPs. Because of their flexibility and disordered nature, it has been difficult to investigate IDPs both computationally and experimentally. In particular, it is desirable to develop coarse-grained, yet accurate models of IDPs, such that simulations exploring sufficient conformational ensembles could be carried out within feasible times. To achieve this goal, we modified the associative memory, water mediated, structure and energy model (AWSEM-MD), which is typically used for folding of globular proteins or binding studies. We tested modified AWSEM-MD on several well-studied IDPs and found the transient secondary structure propensity is consistent with NMR experimental results. The rugged free energy landscapes obtained also show structural heterogeneity of these IDPs. Our proposed extension of AWSEM-MD may allow simulating a wider range of IDPs with high accuracy and computational efficiency.

  1. Agrobacterium tumefaciens-mediated transformation of a taxol-producing endophytic fungus, Cladosporium cladosporioides MD2.

    Science.gov (United States)

    Zhang, Peng; Liu, Ting-Ting; Zhou, Peng-Peng; Li, Shu-Tao; Yu, Long-Jiang

    2011-04-01

    In this study, an Agrobacteriurn tumefaciens-mediated transformation (ATMT) protocol was successfully developed for the genetic transformation of a taxol-producing fungus, Cladosporium cladosporioides MD2, and the co-cultivation conditions affecting the transformation efficiency were optimized. The optimal transformation conditions were that 1 ml of C. cladosporioides MD2 spore suspension (10(8) spores/ml) was mixed with an equal volume of A. tumefaciens cultures, which contained 400 μl of A. tumefaciens LBA4404 (OD(660) ≈ 0.6) and 600 μl LB medium that were used to make up difference in volume, and the mix cultures were supplemented with 300 μM acetosyringone (AS) and co-cultivated at 26°C and 50 rpm for 48 h. Stable transformants were obtained through analysis of the mitotic stability of inserted T-DNA and the presence of hygromycin resistance gene (hpt II). This study laid a fine groundwork for development of transgenic C. cladosporioides MD2 strains.

  2. Theoretical investigation of loratadine reactivity in order to understand its degradation properties: DFT and MD study.

    Science.gov (United States)

    Armaković, Stevan; Armaković, Sanja J; Abramović, Biljana F

    2016-10-01

    Antihistamines are frequently used pharmaceuticals that treat the symptoms of allergic reactions. Loratadine (LOR) is an active component of the second generation of selective antihistaminic pharmaceutical usually known as Claritin. Frequent usage of this type of pharmaceuticals imposes the need for understanding their fundamental reactive properties. In this study we have theoretically investigated reactive properties of LOR using both density functional theory (DFT) calculations and molecular dynamics (MD) simulations. DFT study is used for collecting information related to the molecule stability, structure, frontier molecular orbitals, quantum molecular descriptors, charge distribution, molecular electrostatic potential surfaces, charge polarization, and local reactivity properties according to average local ionization energy surfaces. Based on these results, N24 atom of pyridine ring and oxygen atom O1 were identified with nucleophilic nature. In order to collect the information necessary for the proposition of degradation compounds we also calculated bond dissociation energies (BDE) for hydrogen abstraction and single acyclic bonds as well. According to BDE, the oxidation is likely to occur in the piperidine and cycloheptane rings. MD simulations were used in order to understand the interactions with water through radial distribution functions (RDF). Based on RDFs the most important interactions with solvent are determined for carbon atom C5, chlorine atom Cl15, and oxygen atom O1. Collected results based on DFT calculations and MD simulations provided information important for suggestion of possible degradation compounds. Covalent and noncovalent interactions between LOR and (•)OH have also been investigated. PMID:27640160

  3. Cryptanalysis of Two MD5-Based Authentication Protocols: APOP and NMAC

    Science.gov (United States)

    Wang, Lei; Ohta, Kazuo; Sasaki, Yu; Sakiyama, Kazuo; Kunihiro, Noboru

    Many hash-based authentication protocols have been proposed, and proven secure assuming that underlying hash functions are secure. On the other hand, if a hash function compromises, the security of authentication protocols based on this hash function becomes unclear. Therefore, it is significantly important to verify the security of hash-based protocols when a hash function is broken. In this paper, we will re-evaluate the security of two MD5-based authentication protocols based on a fact that MD5 cannot satisfy a required fundamental property named collision resistance. The target protocols are APOP (Authenticated Post Office Protocol) and NMAC (Nested Message Authentication Code), since they or their variants are widely used in real world. For security evaluation of APOP, we will propose a modified password recovery attack procedure, which is twice as fast as previous attacks. Moreover, our attack is more realistic, as the probability of being detected is lower than that of previous attacks. For security evaluation of MD5-based NMAC, we will propose a new key-recovery attack procedure, which has a complexity lower than that of previous attack. The complexity of our attack is 276, while that of previous attack is 2100.**Moreover, our attack has another interesting point. NMAC has two keys: the inner key and the outer key. Our attack can recover the outer key partially without the knowledge of the inner key.

  4. Solvation structure and dynamics of Na+ in liquid ammonia studied by ONIOM-XS MD simulations

    Science.gov (United States)

    Sripradite, Jarukorn; Tongraar, Anan; Kerdcharoen, Teerakiat

    2015-12-01

    The molecular dynamics (MD) technique based on the ONIOM-XS method, known as the ONIOM-XS MD, has been applied to investigate the solvation structure and dynamics of Na+ in liquid ammonia. Regarding the ONIOM-XS MD results, it is observed that Na+ is able to order the surrounding ammonia molecules to form its specific first and second solvation shells with the average coordination numbers of 5.1 and 11.2, respectively. The first solvation shell of Na+ is rather well-defined, forming a preferred 5-fold coordinated complex with a distorted square pyramidal geometry. In this respect, the most preferential Na+(NH3)5 species could convert back and forth to the lower probability Na+(NH3)6 and Na+(NH3)4 configurations. The second solvation shell of Na+ is detectable, in which a number of ammonia molecules, ranging from 7 to 14, are involved in this layer and they are arranged according to recognizable influence of the ion.

  5. Going beyond clustering in MD trajectory analysis: an application to villin headpiece folding.

    Directory of Open Access Journals (Sweden)

    Aruna Rajan

    Full Text Available Recent advances in computing technology have enabled microsecond long all-atom molecular dynamics (MD simulations of biological systems. Methods that can distill the salient features of such large trajectories are now urgently needed. Conventional clustering methods used to analyze MD trajectories suffer from various setbacks, namely (i they are not data driven, (ii they are unstable to noise and changes in cut-off parameters such as cluster radius and cluster number, and (iii they do not reduce the dimensionality of the trajectories, and hence are unsuitable for finding collective coordinates. We advocate the application of principal component analysis (PCA and a non-metric multidimensional scaling (nMDS method to reduce MD trajectories and overcome the drawbacks of clustering. To illustrate the superiority of nMDS over other methods in reducing data and reproducing salient features, we analyze three complete villin headpiece folding trajectories. Our analysis suggests that the folding process of the villin headpiece is structurally heterogeneous.

  6. 试论MD5算法的安全分析及破解

    Institute of Scientific and Technical Information of China (English)

    马珂

    2014-01-01

    本文介绍了MD5加密算法原理及利用MD5加密算法保护网络上传输的用户登录信息以及破译算法,并介绍了差分的引入原则,分析了MD5算法迭代中差分路径的方法,利用非线性函数的性质和差分的扩展来引导中间差分的继承、产生和消除。

  7. Web开发中MD5摘要计算的应用——Struts技术实现

    Institute of Scientific and Technical Information of China (English)

    鲁屹华

    2008-01-01

    首先介绍了MD5算法的概念,然后阐述了Java语言的java.security包对MD5算法的支持,并基于Sun公司Java2平台企业版(J2EE)MVC框架Struts技术,针对B/S模式毕业设计选题系统中的学生基本信息注册模块所采用的MD5摘要计算作了详细介绍.

  8. MD5防碰撞和穷举变换算法的研究与实现

    Institute of Scientific and Technical Information of China (English)

    刘红军

    2008-01-01

    分析MD5加密算法和碰撞的原理,对目前常规MD5算法加密结果容易被破解的问题,在java. security包提供的MD5算法基础上给出了多种变换算法,以进一步减小破解时的碰撞概率,增强系统加密的安全性.

  9. 关于MD5算法的分析及其性能优化

    Institute of Scientific and Technical Information of China (English)

    崔永辉; 徐鹏; 阳征鹏

    2015-01-01

    本文主要介绍了MD5算法的实现原理和对源数据信息的加密流程,然后从算法实现的角度,依据当前CPU计算机制,对MD5算法的计算时间的消耗进行分析,并提出了相应的性能优化建议,从而提升MD5算法的计算速度。

  10. The topology of foliations formed by the generic K-orbits of a subclass of the indecomposable MD5-groups

    Science.gov (United States)

    Vu, Le Anh; Hoa, Duong Quang

    2009-03-01

    The present paper is a continuation of [13], [14] of the authors. Specifically, the paper considers the MD5-foliations associated to connected and simply connected MD5-groups such that their Lie algebras have 4-dimensional commutative derived ideal. In the paper, we give the topological classification of all considered MD5-foliations. A description of these foliations by certain fibrations or suitable actions of $\\mathbb{R}^{2}$ and the Connes' C*-algebras of the foliations which come from fibrations are also given in the paper.

  11. The Algorithm Design for Preventing URL Modified Based on MD5%基于MD5的URL防篡改算法设计

    Institute of Scientific and Technical Information of China (English)

    刘国卿

    2011-01-01

    针对常用的URL篡改攻击,提出了一种基于MD5加密的URL防篡改算法。该算法将一段哈希代码作为校验码附加到目标URL后,在页面逻辑运行完成前采用过滤器实现校验码的比对,从而完成URL是否被篡改的判断;最后,基于.NET平台实现了新链接生成模块和校验模块,并讨论了模块的部署。%For preventing URL modified, this paper proposed a algorithm design, which could be used to cheek out the modification of URL efficiently. The algorithm adds a hashed MAC to order URL,it makes it posible to learn whether the URL he modified. Furthermore,

  12. A Greedy Algorithm to solve md-MST Problem Based on Edgeexchange%一种基于边交换的贪心算法求解md-MST问题

    Institute of Scientific and Technical Information of China (English)

    赵磊; 刘辉; 魏书堤; 陈坚祯; 林睦纲

    2015-01-01

    通过对最小度限制最小生成树(md-MST)问题性质进行分析,提出了一种基于边交换的贪心算法.算法先用贪心算法生成一棵生成树ST,然后对生成树ST经过边交换调整,得到满足问题约束条件的可行解,再对生成树ST进行进一步边交换优化,得到md-MST问题的最优解或接近最优解的近似解.实验证明,算法能在短时间内求出大规模顶点随机图的md-MST,是一种非常实用的求解md-MST问题的精确算法.

  13. MD5报文摘要算法与文件系统完整性保护%MD5 Message Digest Algorithm and Protection of File System Integrity

    Institute of Scientific and Technical Information of China (English)

    李杰; 张学旺

    2003-01-01

    MD5报文摘要算法是一种应用广泛的提取数字指纹的算法.文件系统完成性保护利用MD5算法产生文件或对象的数字指纹以识别它们的微小变化而实施保护.本文详细剖析了MD5算法的工作原理,以及基于MD5算法的文件系统完整性检查程序的原理、设计和实现.

  14. The application of MD5 algorithm in telephone speech system software protection%MD5算法在电话语音系统软件保护中的应用

    Institute of Scientific and Technical Information of China (English)

    段青玲; 杨仁刚; 李辉

    2007-01-01

    本文首先对软件保护技术进行了简要的概述,在剖析MD5算法工作原理的基础上,提出了基于MD5加密算法的软件硬加密保护方案.该方案根据机器的CPU序列号和语音卡号使用MD5加密算法自动生成软件序列号,并对MD5加密算法的输入输出数据进行变化处理.结果显示,该方法实现了"一机一码",并已应用于某"电话语音系统"中.

  15. 基于MD5加密的Tornado码复制算法改进%An improved algorithm based on MD5 encryption Tornado code

    Institute of Scientific and Technical Information of China (English)

    骆正平; 陈中育; 林郁峰; 吴星同

    2015-01-01

    Tornado code based replication algorithm had the advantages of faster encoding and decoding, and could also recover the original data when some data were missing, but when the algorithm was applied to a dis-tributed storage system, the presence of data would be susceptible to theft, tampering risk. For this reason, several optimization strategies were proposed to improve the replication algorithm based on Tornado code:1 ) an encryption mechanism into replication algorithm was introduced in case of even some data were stolen there would be no worry about information leak. 2)the raw data using the MD5 algorithm to generate digital finger-prints produced a digital fingerprint when retrieving data from a distributed storage system with local digital fin-gerprint comparison, it would be easy to determine whether the data had been tampered with.%基于Tornado码的复制算法具有编解码速度比较快、部分数据丢失时亦能被恢复的优点,但将该算法应用于分布式存储系统时,存在数据易被窃取、篡改的风险。为此,对基于Tornado码的复制算法提出了改进:1)引入加密机制,使数据即使被窃取时也不用担心泄密;2)对原始数据使用MD5算法产生数字指纹,当从分布式存储系统取回数据时,计算数字指纹并与本地的数字指纹对比,就可以判断数据是否被篡改。

  16. An improved algorithm based on MD5 encryption Tornado code%基于MD5加密的Tornado码复制算法改进

    Institute of Scientific and Technical Information of China (English)

    骆正平; 陈中育; 林郁峰; 吴星同

    2015-01-01

    基于Tornado码的复制算法具有编解码速度比较快、部分数据丢失时亦能被恢复的优点,但将该算法应用于分布式存储系统时,存在数据易被窃取、篡改的风险。为此,对基于Tornado码的复制算法提出了改进:1)引入加密机制,使数据即使被窃取时也不用担心泄密;2)对原始数据使用MD5算法产生数字指纹,当从分布式存储系统取回数据时,计算数字指纹并与本地的数字指纹对比,就可以判断数据是否被篡改。%Tornado code based replication algorithm had the advantages of faster encoding and decoding, and could also recover the original data when some data were missing, but when the algorithm was applied to a dis-tributed storage system, the presence of data would be susceptible to theft, tampering risk. For this reason, several optimization strategies were proposed to improve the replication algorithm based on Tornado code:1 ) an encryption mechanism into replication algorithm was introduced in case of even some data were stolen there would be no worry about information leak. 2)the raw data using the MD5 algorithm to generate digital finger-prints produced a digital fingerprint when retrieving data from a distributed storage system with local digital fin-gerprint comparison, it would be easy to determine whether the data had been tampered with.

  17. MD3600塔吊在索塔施工中的几个关键问题%Several Key Issues on MD3600 Tower Cranes Used for Construction of Bridge Pylons

    Institute of Scientific and Technical Information of China (English)

    沈斌; 谢发祥

    2007-01-01

    MD3600塔吊是南京长江第三大桥和苏通大桥索塔施工的关键设备,结合2座大桥工程实例介绍MD3600塔吊在索塔施工中的布置、基础、附墙、抗风安全的主要内容.

  18. A Method that Preventing URL Attack Based on MD5 Encryption Algorithm%一种采用MD5加密算法防止URL攻击的方法

    Institute of Scientific and Technical Information of China (English)

    张杰; 李华伟; 周立军

    2011-01-01

    在简要分析当前URL攻击手段的基础上,提出一种使用MD5加密算法有效防止URL攻击的方法,按照URL合法性检测流程,设计基于Java MVC轻量级框架Struts的测试方案,比较MD5和DES算法在URL参数加密过程中的性能.

  19. MD5加密算法改进及其特征码在杀毒软件中的应用%An improved MD5 encryption algorithm and application in anti-virus software

    Institute of Scientific and Technical Information of China (English)

    贾晓强

    2015-01-01

    文章分析了MD5算法发展、危机、碰撞分析并加入"盐值"对算法做了改进,然后给出了其C++的具体实现算法;分析MD5特征码的特点构建了特征库配置文件,用VC实现了基于特征码的杀毒软件,此软件能根据文件特征码(MD5值)成功删除可疑文件。%The paper analyzed the development, crisis and the collision of the MD5 algorithm,by adding the"salt value", the algorithm has been improved. And then gived the concrete implementation of the algorithm with c++language;Analysis of the characteristics of the MD5 signature feature ,database configuration file is constructed, using VC implementation anti-virus software based on signature feature, the software can according to the file signature (MD5 value) successfully delete suspicious files.

  20. Application of MD5 Encryption Algorithm in Registration and Login Verification Module%MD5加密算法在注册及登录验证模块中的应用

    Institute of Scientific and Technical Information of China (English)

    周小红; 周建伙

    2015-01-01

    With the development of Internet technology,information security is becoming more and more popular.This pa-per introduces the basic principle of the MD5 encryption algorithm.The application of MD5 encryption algorithm in the regis-tration and login verification module in the.NET environment through Visual C# is introduced in detail.The security of MD5 al-gorithm is analyzed.Final y,put forward and realize the improvement method.%随着互联网技术的发展,信息安全越来越受到人们的关注。介绍了MD5加密算法的基本原理,详细介绍如何在。 NET环境下通过Visual C#实现MD5加密算法在注册及登录验证模块中的应用。分析MD5算法的安全性,最后提出并实现自己的改进方法。

  1. 78 FR 28229 - Prospective Grant of Exclusive License: Device and System for Expression Microdissection (xMD)

    Science.gov (United States)

    2013-05-14

    ... for Expression Microdissection (xMD) AGENCY: National Institutes of Health, HHS. ACTION: Notice... inspection and, to the extent permitted by law, will not be released under the Freedom of Information Act,...

  2. 浅谈六种加密算法之三——MD5算法

    Institute of Scientific and Technical Information of China (English)

    周庆

    2005-01-01

    MD5的全称是“nessage-digest algorithm 5”(信息-摘要算法),它是90年代初由MIT计算机科学实验室和RSA Data Security Inc联合开发,并经过MD2、MD3和MD4逐渐演变而来的。其主要作用是让大容量信息在用数字签名软件签署私人“密匙”前被“压缩”成一种保密的格式(就是把一个任意长度的字符串转变成一定长度的大整数),

  3. 基于MD5算法安全性研究发展及分析

    Institute of Scientific and Technical Information of China (English)

    赵光亮; 韦雅文

    2015-01-01

    针对当前手机应用开发中用户信息等重要数据的安全问题,提出了一种MD5加密算法对用户信息进去加密。MD5是一种安全性很高的单向加密Hash函数,通过对该算法的深入研究,介绍了关于MD5的算法原理及其特性和破解原理进行阐述,得出MD5算法目前是一种常用并且安全的加密算法。

  4. Seismicity patterns before MD >= 4.1 earthquakes in the Friuli-Venezia Giulia (northeastern Italy) and western Slovenia areas

    OpenAIRE

    Gentili, Stefania; Bressan, Gianni

    2007-01-01

    International audience The spatial-temporal pattern of seismicity, preceding 5 moderate-sized earthquakes with MD ≥ 4.1, that occurred in the Friuli-Venezia Giulia region (northeastern Italy) and in western Slovenia, is investigated with the Region-Time-Length (RTL) and the PI algorithms. These algorithms were originally formulated to reveal the variation of seismicity patterns before large earthquakes. The RTL algorithm detects seismic quiescences before the 1996 Claut earthquake (MD 4.3)...

  5. An assessment of communication skills of the MD/MS students of institute of medicine in Nepal

    OpenAIRE

    Jagdish Prasad Agrawal; Mandira Shahi

    2013-01-01

    Introduction The main objective of this study was to assess the level of interpersonal communication skills of MD/MS resident doctors and to provide recommendations for the future. Methods Descriptive, cross sectional, qualitative and quantitative research design was used. 7- point Likert scale (0 to 6) MAAS-Global scoring instrument was used. The subjects of the research were the MD/MS residents from various departments of Maharajgunj Medical Campus (MMC) of Institute of Medicine, Maharajgu...

  6. Safety and efficacy of a backpassaged rMd5-delta-Meq vaccine virus in chickens

    Science.gov (United States)

    Marek’s disease virus EcoR1-Q fragment of the viral genome encodes meq (MDV EcoQ) gene. Meq is an unique oncogene, present only in serotype 1 MDV and is consistently expressed in all latent or tumor cells. The meq gene was deleted from the very virulent rMd5 genome and was designated as rMd5-delta-M...

  7. Message Digest Algorithm 5 Apply in PHP+MYSQL%MD5算法在PHP+MYSQL中的应用

    Institute of Scientific and Technical Information of China (English)

    苟玮; 姚旺生; 郭福亮

    2007-01-01

    在以web形式提供服务的系统中,用户从浏览器登录服务器数据库时,信息的安全性至关重要.主要讨论MD5算法在PHP+MYSQL中的应用,分析MD5算法的不足并提出了解决方法.

  8. 在J2ME中使用MD5加密算法研究

    Institute of Scientific and Technical Information of China (English)

    王刚

    2005-01-01

    由于消息摘要具有唯一性和不可逆性的特点,所以不失为一种简单的常用的加密手段。对MD5(Message-Digest Algorithm5)算法做了描述,并实现了在J2ME中使用MD5加密传输数据。

  9. House M.D.: the monitoring of life, crime and disease in the age of its technical visuality

    OpenAIRE

    Ivana Bentes

    2011-01-01

    When the body, the subjectivity and disease are converted into medical information, statistics and ballistics, MRI, contrasts, maps and images, they appear as new actors and dramatic elements in contemporary fiction, especially in series as House M.D. and CSI. In this article, we analyze some House M.D. episodes, highlighting how these body visualization technologies, genetic mapping, diagnostics, monitoring procedures, equipment for production of evidences of every kind (medical and criminal...

  10. Kinetics of CH4 and CO2 hydrate dissociation and gas bubble evolution via MD simulation.

    Science.gov (United States)

    Uddin, M; Coombe, D

    2014-03-20

    Molecular dynamics simulations of gas hydrate dissociation comparing the behavior of CH4 and CO2 hydrates are presented. These simulations were based on a structurally correct theoretical gas hydrate crystal, coexisting with water. The MD system was first initialized and stabilized via a thorough energy minimization, constant volume-temperature ensemble and constant volume-energy ensemble simulations before proceeding to constant pressure-temperature simulations for targeted dissociation pressure and temperature responses. Gas bubble evolution mechanisms are demonstrated as well as key investigative properties such as system volume, density, energy, mean square displacements of the guest molecules, radial distribution functions, H2O order parameter, and statistics of hydrogen bonds. These simulations have established the essential similarities between CH4 and CO2 hydrate dissociation. The limiting behaviors at lower temperature (no dissociation) and higher temperature (complete melting and formation of a gas bubble) have been illustrated for both hydrates. Due to the shift in the known hydrate stability curves between guest molecules caused by the choice of water model as noted by other authors, the intermediate behavior (e.g., 260 K) showed distinct differences however. Also, because of the more hydrogen-bonding capability of CO2 in water, as reflected in its molecular parameters, higher solubility of dissociated CO2 in water was observed with a consequence of a smaller size of gas bubble formation. Additionally, a novel method for analyzing hydrate dissociation based on H-bond breakage has been proposed and used to quantify the dissociation behaviors of both CH4 and CO2 hydrates. Activation energies Ea values from our MD studies were obtained and evaluated against several other published laboratory and MD values. Intrinsic rate constants were estimated and upscaled. A kinetic reaction model consistent with macroscale fitted kinetic models has been proposed to

  11. The scope and variety of combined baccalaureate-MD programs in the United States.

    Science.gov (United States)

    Eaglen, Robert H; Arnold, Louise; Girotti, Jorge A; Cosgrove, Ellen M; Green, Marianne M; Kollisch, Donald O; McBeth, Dani L; Penn, Mark A; Tracy, Sarah W

    2012-11-01

    The landscape of combined baccalaureate-MD programs has changed substantially in the last two decades but has not been documented in detail. The authors review the current state of these programs and discuss opportunities for future study of their evolving role and potential impact.In 2011, using a definition of baccalaureate-MD program built on prior research, the authors reviewed Association of American Medical Colleges sources and medical school Web sites to identify and characterize 81 active programs. In addition, they surveyed the 57 medical schools offering those programs; 31 schools with 39 programs responded. The resulting database inventories the number and distribution of programs; institutional affiliations; missions or goals; length; size; admissions criteria; curricula; and retention requirements.Since the inception of combined programs in 1961, their number and curricular length have increased. Pressures that spurred earlier programs remain evident in the goals of today's programs: attract talented high school or early college students, especially from diverse backgrounds; prepare physicians to meet societal needs; and offer an enriched premedical environment. Baccalaureate educational activities achieve program goals through special courses, medical experiences, community service, and learning communities tailored to students' needs. Admission and retention criteria are comparable to those of traditional medical schools.Combined baccalaureate-MD programs have evolved along several paths during the last half century and have enriched the baccalaureate experiences of medical students. Shifting expectations for the selection and education of future physicians warrant focused research on these programs to document their effectiveness in addressing those expectations. PMID:23018320

  12. A workshop on leadership for senior MD-PhD students.

    Science.gov (United States)

    Meador, Catherine B; Parang, Bobak; Musser, Melissa A; Haliyur, Rachana; Owens, David A; Dermody, Terence S

    2016-01-01

    Leadership skills are essential for a successful career as a physician-scientist, yet many MD-PhD training programs do not offer formal training in leadership. The Vanderbilt Medical Scientist Training Program (MSTP) previously established a 2-day leadership workshop that has been held biennially since 2006 for students in the first and second years of the graduate school portion of combined MD and PhD training (G1/G2 students). Workshop attendees have consistently rated this workshop as a highly effective experience. However, opportunities for structured training in leadership competencies during the subsequent 3-5 years of MD-PhD training are limited. Given the success of the G1/G2 leadership workshop and the need for continuity in this model of leadership training, we developed a half-day workshop for MSTP students in the clinical years of medical school (M3/M4 students) to foster continued training in leadership. Our workshop curriculum, based in part on original cases drafted by Vanderbilt MSTP students, provides concrete strategies to manage conflict and navigate leadership transitions in the physician-scientist career path. The curriculum emphasizes both short-term competencies, such as effective participation as a member of a clinical team, and long-term competencies, such as leadership of a research team, division, or department. Our inaugural senior leadership workshop, held in August, 2015, was judged by student participants to be well organized and highly relevant to leadership concepts and skills. It will be offered biennially in our training curriculum for M3 and M4 MSTP students. PMID:27499363

  13. Understanding the mechanism of LCST phase separation of mixed ionic liquids in water by MD simulations.

    Science.gov (United States)

    Zhao, Yuling; Wang, Huiyong; Pei, Yuanchao; Liu, Zhiping; Wang, Jianji

    2016-08-17

    Recently, it has been found experimentally that two different amino acid ionic liquids (ILs) can be mixed to show unique lowest critical solution temperature (LCST) phase separation in water. However, little is known about the mechanism of phase separation in these IL/water mixtures at the molecular level. In this work, five kinds of amino acid ILs were chosen to study the mechanism of LCST-type phase separation by molecular dynamics (MD) simulations. Toward this end, a series of all-atom MD simulations were carried out on the ternary mixtures consisting of two different ILs and water at different temperatures. The various interaction energies and radial distribution functions (RDFs) were calculated and analyzed for these mixed systems. It was found that for amino acid ILs, the -NH2 or -COOH group of one anion could have a hydrogen bonding interaction with the -COO(-) group of another anion. With the increase of temperature, this kind of hydrogen bonding interaction between anions was strengthened and then the anion-H2O electrostatic interaction was weakened, which led to the LCST-type phase separation of the mixed ILs in water. In addition, a series of MD simulations for [P6668]1[Lys]n[Asp]1-n/H2O systems were also performed to study the effect of the mixing ratio of ILs on phase separation. It was also noted that the experimental critical composition corresponding to the lowest critical solution temperature was well predicted from the total electrostatic interaction energies as a function of mole fraction of [P6668][Lys] in these systems. The conclusions drawn from this study may provide new insight into the LCST-type phase behavior of ILs in water, and motivate further studies on practical applications. PMID:27498928

  14. Dynamics of biopolymers on nanomaterials studied by quasielastic neutron scattering and MD simulations

    Science.gov (United States)

    Dhindsa, Gurpreet K.

    Neutron scattering has been proved to be a powerful tool to study the dynamics of biological systems under various conditions. This thesis intends to utilize neutron scattering techniques, combining with MD simulations, to develop fundamental understanding of several biologically interesting systems. Our systems include a drug delivery system containing Nanodiamonds with nucleic acid (RNA), and two specific model proteins, beta-Casein and Inorganic Pyrophosphatase (IPPase). RNA and nanodiamond (ND) both are suitable for drug-delivery applications in nano-biotechnology. The architecturally flexible RNA with catalytic functionality forms nanocomposites that can treat life-threatening diseases. The non-toxic ND has excellent mechanical and optical properties and functionalizable high surface area, and thus actively considered for biomedical applications. In this thesis, we utilized two tools, quasielastic neutron scattering (QENS) and Molecular Dynamics Simulations to probe the effect of ND on RNA dynamics. Our work provides fundamental understanding of how hydrated RNA motions are affected in the RNA-ND nanocomposites. From the experimental and Molecular Dynamics Simulation (MD), we found that hydrated RNA motion is faster on ND surface than a freestanding one. MD Simulation results showed that the failure of Stokes Einstein relation results the presence of dynamic heterogeneities in the biomacromolecules. Radial pair distribution function from MD Simulation confirmed that the hydrophilic nature of ND attracts more water than RNA results the de-confinement of RNA on ND. Therefore, RNA exhibits faster motion in the presence of ND than freestanding RNA. In the second project, we studied the dynamics of a natively disordered protein beta-Casein which lacks secondary structures. In this study, the temperature and hydration effects on the dynamics of beta-Casein are explored by Quasielastic Neutron Scattering (QENS). We investigated the mean square displacement (MSD) of

  15. Direct MD simulation of liquid-solid phase equilibria for two-component plasmas

    OpenAIRE

    Schneider, A. S.; Hughto, J.; Horowitz, C. J.; Berry, D. K.

    2011-01-01

    We determine the liquid-solid phase diagram for carbon-oxygen and oxygen-selenium plasma mixtures using two-phase MD simulations. We identified liquid, solid, and interface regions using a bond angle metric. To study finite size effects, we perform 27648 and 55296 ion simulations. To help monitor non-equilibrium effects, we calculate diffusion constants $D_i$. For the carbon-oxygen system we find that $D_O$ for oxygen ions in the solid is much smaller than $D_C$ for carbon ions and that both ...

  16. Synergistic Applications of MD and NMR for the Study of Biological Systems

    Directory of Open Access Journals (Sweden)

    Olivier Fisette

    2012-01-01

    same time, theoretical and computational approaches gain in reliability and their field of application widens. In this short paper, we discuss recent advances in the areas of solution nuclear magnetic resonance (NMR spectroscopy and molecular dynamics (MD simulations that were made possible by the combination of both methods, that is, through their synergistic use. We present the main NMR observables and parameters that can be computed from simulations, and how they are used in a variety of complementary applications, including dynamics studies, model-free analysis, force field validation, and structural studies.

  17. Rekonstrukcija i izrada 3D modela dvo-osne konvencionalne tokarilice Hobbymat MD65

    OpenAIRE

    Hršak, Božidar; Pavlic, Tomislav; Radić, Antonio

    2014-01-01

    Prikazan je postupak rekonstrukcije konvencionalne tokarilice Hobbymat MD65 u CNC (Computer Numerical Control) stroj s dvije simultane osi ugradnjom koračnih motora tipa NEMA 23 i upravljanih PC programskim sustavom Mach3-Lathe. 3D model je izrađen u programskom alatu Solid Edge ST4 – Ordered Technology, a fotorealistički prikaz modela u programskom modulu ERA (ExplodeRenderAnimate). Na temelju dokumentacije o montaži i održavanju i mjernih skica izrađena je kompletna 2D tehnička dokumentacij...

  18. A Conversation with David Bates, MD, MSc, Chairman of the American Medical Informatics Association

    OpenAIRE

    Raymond, Brian

    2008-01-01

    A world-renowned physician-researcher, David Bates, MD, MSc, is Chief of the Division of General Medicine at the Brigham and Women's Hospital in Boston, MA, and a Professor at Harvard Medical School and the Harvard School of Public Health, where he is codirector of the Program in Clinical Effectiveness. He is the Medical Director of Clinical and Quality Analysis, Information Systems at Partners HealthCare System, Inc. He is also the former Chair of the National Alliance for Primary Care Infor...

  19. A workshop on leadership for senior MD-PhD students

    OpenAIRE

    Meador, Catherine B.; Parang, Bobak; Musser, Melissa A.; Haliyur, Rachana; Owens, David A.; Terence S Dermody

    2016-01-01

    Leadership skills are essential for a successful career as a physician-scientist, yet many MD–PhD training programs do not offer formal training in leadership. The Vanderbilt Medical Scientist Training Program (MSTP) previously established a 2-day leadership workshop that has been held biennially since 2006 for students in the first and second years of the graduate school portion of combined MD and PhD training (G1/G2 students). Workshop attendees have consistently rated this workshop as a hi...

  20. SN 2009md: Another faint supernova from a low mass progenitor

    OpenAIRE

    Fraser, M; Ergon, M.; Eldridge, J. J.; Valenti, S.; Pastorello, A.; Sollerman, J; Smartt, S. J.; Agnoletto, I.; Arcavi, I.; Benetti, S.; Botticella, M. -T.; Bufano, F.; Campillay, A.; Crockett, R. M.; Gal-Yam, A.

    2010-01-01

    We present adaptive optics imaging of the core collapse supernova (SN) 2009md, which we use together with archival \\emph{Hubble Space Telescope} data to identify a coincident progenitor candidate. We find the progenitor to have an absolute magnitude of $V = -4.63^{+0.3}_{-0.4}$ mag and a colour of $V-I = 2.29^{+0.25}_{-0.39}$ mag, corresponding to a progenitor luminosity of log $L$/L$_{\\odot}$ $\\sim4.54\\pm0.19$ dex. Using the stellar evolution code STARS, we find this to be consistent with a ...

  1. Neutron emission as a function of fragment energy in the spontaneous fission of 260Md

    International Nuclear Information System (INIS)

    The authors have made the first measurement of the number of neutrons emitted in the spontaneous fission of a nuclide in which very high fragment energies dominate the fission process. In bombardments of 254Es, they produced 28-d 260Md, which was neutron-counted in a 1-m-diam spherical tank containing a Gd-doped scintillator solution. The average number of neutrons emitted per fission is only 2.58 ± 0.11, substantially less than for other actinides. A direct correlation of neutron multiplicity with fragment excitation energy is clearly demonstrated

  2. A Study of the Adsorption of Molecular Deposition Filming Flooding Agent MD-1 on Quartz Sand%MD-1膜驱剂在石英砂上的吸附

    Institute of Scientific and Technical Information of China (English)

    高芒来; 刘勇; 孟秀霞; 王建设

    2004-01-01

    Molecular deposition filming flooding (MDFF) is a novel oil recovery technique based on the thermopositive monolayer electrostatic adsorption of the MDFF agent on different interfaces within reservoir systems. In this paper, the adsorption property of the MDFF agent, MD-1, on quartz sand has been studied through adsorption experiments at different pH and temperatures. Experimental data are also analyzed kinetically and thermodynamically. The results show that the adsorption of MD-1 on quartz sand takes place mainly because of electrostatic interactions, which corresponds to adsorption that increases with pH. Kinetic analyses show that at a higher pH the activation energy for adsorption gets lower and, therefore, the adsorption becomes quicker for MD-1 on quartz sand. Thermodynamic analyses show that pH plays an important role in the adsorption of MD-1 on quartz sand. At a higher pH, more negative surface charges result in the increase of electrostatic interactions between MD-1 and quartz sand. Therefore, the saturated adsorption amount increases and more adsorption heat will be released.%分子沉积(MD)膜驱油技术是依靠MD膜驱剂分子在油藏体系的各种界面上通过静电作用形成单层MD膜释放热量,从而提高原油采收率的新型技术.利用静态吸附法研究了不同pH值下MD-1膜驱剂在石英砂上的静电吸附特性,并进行吸附动力学和热力学分析.实验结果表明,MD-1膜驱剂在石英砂上的吸附主要由静电作用引起的,其吸附量随着pH值的增加而增大.动力学计算表明,pH值越高,石英砂表面所带负电越多,对MD-1膜驱剂吸附的活化能越低,吸附MD-1膜驱剂的速度越快;热力学计算表明,MD-1膜驱剂在石英砂上的吸附受pH值影响较大.pH值越高,石英砂表面所带负电越多,石英砂与MD-1膜驱剂间的静电引力越大,MD-1膜驱剂在石英砂上的理论饱和吸附量越大,吸附放热越多.

  3. Numerical analysis of MD events and preliminary thermal calculation for KTX vacuum vessel

    Energy Technology Data Exchange (ETDEWEB)

    Shi, Shanshuang, E-mail: shiss@ipp.ac.cn [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China); Song, Yuntao; Yang, Qingxi; Xu, Hao; Wang, Zhongwei [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China); Liu, Wandong; Li, Hong; Wan, Shude; Ding, Weixing [School of Physical Sciences, University of Science and Technology of China, Hefei 230031 (China); Luo, Zhiren; Zheng, Jinxing [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China)

    2013-12-15

    Highlights: • To verify design strength, EM and mechanical analysis was implemented. • During MD events, the radial force due to large eddy current is predominant. • We confirmed the VV structure is still strong enough even in the most severe condition. • Preliminary thermal calculation suggested suitable discharge parameters. -- Abstract: KTX is a new reversed field pinch (RFP) magnetic confinement device which is under design in ASIPP and USTC. Major disruption (MD) events may occur in future operating process, which is simulated with the finite element (FE) method. The results present that the peaks of eddy currents on vessel and conductor shell are respectively 11.791 kA and 68.637 kA with maximum stress 67.1 MPa due to high transient electromagnetic (EM) force. It is confirmed that the structure is still strong enough to bear the electromagnetic loads even if the worst case. Besides, as KTX vacuum vessel will take the method of natural cooling for heat dissipation during plasma discharge (0.5–1.0 MA), a preliminary thermal calculation was implemented in normal condition to decide suitable time parameters such as duration and interval. It is suggested that the discharge interval should be no less than 5 min for the complete 1 MA plasma with 100 ms duration, which can guarantee the temperature of vacuum vessel below 200 °C.

  4. Numerical analysis of MD events and preliminary thermal calculation for KTX vacuum vessel

    International Nuclear Information System (INIS)

    Highlights: • To verify design strength, EM and mechanical analysis was implemented. • During MD events, the radial force due to large eddy current is predominant. • We confirmed the VV structure is still strong enough even in the most severe condition. • Preliminary thermal calculation suggested suitable discharge parameters. -- Abstract: KTX is a new reversed field pinch (RFP) magnetic confinement device which is under design in ASIPP and USTC. Major disruption (MD) events may occur in future operating process, which is simulated with the finite element (FE) method. The results present that the peaks of eddy currents on vessel and conductor shell are respectively 11.791 kA and 68.637 kA with maximum stress 67.1 MPa due to high transient electromagnetic (EM) force. It is confirmed that the structure is still strong enough to bear the electromagnetic loads even if the worst case. Besides, as KTX vacuum vessel will take the method of natural cooling for heat dissipation during plasma discharge (0.5–1.0 MA), a preliminary thermal calculation was implemented in normal condition to decide suitable time parameters such as duration and interval. It is suggested that the discharge interval should be no less than 5 min for the complete 1 MA plasma with 100 ms duration, which can guarantee the temperature of vacuum vessel below 200 °C

  5. Portuguese validation of the Symptom Inventory of the M.D. Anderson Cancer Center

    Directory of Open Access Journals (Sweden)

    Adriane Cristina Bernat Kolankiewicz

    2014-12-01

    Full Text Available Objective To analyze the reliability and validity of the psychometric properties of the Brazilian version of the instrument for symptom assessment, titled MD Anderson Symptom Inventory - core. Method A cross-sectional study with 268 cancer patients in outpatient treatment, in the municipality of Ijuí, state of Rio Grande do Sul, Brazil. Results The Cronbach’s alpha for the MDASI general, symptoms and interferences was respectively (0.857, (0.784 and (0.794. The factor analysis showed adequacy of the data (0.792. In total, were identified four factors of the principal components related to the symptoms. Factor I: sleep problems, distress (upset, difficulties in remembering things and sadness. Factor II: dizziness, nausea, lack of appetite and vomiting. Factor III: drowsiness, dry mouth, numbness and tingling. Factor IV: pain, fatigue and shortness of breath. A single factor was revealed in the component of interferences with life (0.780, with prevalence of activity in general (59.7%, work (54.9% and walking (49.3%. Conclusion The Brazilian version of the MD Anderson Symptom Inventory - core showed adequate psychometric properties in the studied population.

  6. The embedded atom model and large-scale MD simulation of tin under shock loading

    International Nuclear Information System (INIS)

    The goal of the work was to develop an interatomic potential, that can be used in large-scale classical MD simulations to predict tin properties near the melting curve, the melting curve itself, and the kinetics of melting and solidification when shock and ramp loading. According to phase diagram, shocked tin melts from bcc phase, and since the main objective was to investigate melting, the EAM was parameterized for bcc phase. The EAM was optimized using isothermal compression data (experimental at T=300 K and ab-initio at T=0 K for bcc, fcc, bct structures), experimental and QMD data on the Hugoniot and on the melting at elevated pressures. The Hugoniostat calculations centred at β-tin at ambient conditions showed that the calculated Hugoniot is in good agreement with experimental and QMD data above p-bct transition pressure. Calculations of overcooled liquid in pressure range corresponding to bcc phase showed crystallization into bcc phase. Since the principal Hugoniot of tin originates from the β-tin that is not described by this EAM the special initial state of bcc samples was constructed to perform large-scale MD simulations of shock loading.

  7. Numerical simulations of magnetic materials with MD-GRAPE: curvature induced anisotropy

    International Nuclear Information System (INIS)

    The time development of an array of magnetic dipoles representing the internal magnetization of a thin film is calculated using a hardware accelerator, MD-GRAPE, for the determination of the magnetic vector potential. The results for single-layer arrays of dipoles are compared with the analogous results obtained from an FFT method and found to be in reasonable agreement. Three-dimensional MD-GRAPE simulations with sinusoidal deformations illustrate the utility of the hardware accelerator in cases that cannot be solved easily with FFT methods. The deformations give the internal field an asymmetry with components parallel to the wave crest, leading to significant changes in the critical external fields required for switching. These changes occur even for small wave amplitudes, comparable to or less than the layer thickness. Layer curvature affects the astroid pattern of critical field strengths by shifting the threshold to lower absolute values of the hard axis field when the curvature is in the easy axis direction, and lower absolute values of the easy axis field when the curvature is in the hard axis direction. This effect of curvature differs from orange peel coupling between two layers because here there is only one layer, and because orange peel coupling shifts the whole astroid pattern as a result of an effective field bias, whereas here the pattern shape is changed without any centroid shift

  8. SN 2009md: Another faint supernova from a low mass progenitor

    CERN Document Server

    Fraser, M; Eldridge, J J; Valenti, S; Pastorello, A; Sollerman, J; Smartt, S J; Agnoletto, I; Arcavi, I; Benetti, S; Botticella, M -T; Bufano, F; Campillay, A; Crockett, R M; Gal-Yam, A; Kankare, E; Leloudas, G; Maguire, K; Mattila, S; Maund, J R; Salgado, F; Stephens, A; Taubenberger, S; Turatto, M

    2010-01-01

    We present adaptive optics imaging of the core collapse supernova (SN) 2009md, which we use together with archival HST data to identify a coincident progenitor candidate. We find the progenitor to have an absolute magnitude of $V = -4.63^{+0.3}_{-0.4}$ mag and a colour of $V-I = 2.29^{+0.25}_{-0.39}$ mag, corresponding to a progenitor luminosity of log $L$/\\lsun $\\sim4.3\\pm0.2$ dex. Using the stellar evolution code STARS, we find this to be consistent with a red supergiant progenitor with $M = 7_{-1}^{+5}$ \\msun. The photometric and spectroscopic evolution of SN 2009md is similar to that of the class of sub-luminous Type IIP SNe. We estimate the mass of $^{56}$Ni ejected in the explosion to be $(5.4\\pm1.3) \\times 10^{-3}$ \\msun\\ from the luminosity on the radioactive tail, which is in agreement with the low $^{56}$Ni masses estimated for other sub-luminous Type IIP SNe. Simple modeling of the SN is presented, where we include a constraint on the radius from progenitor observations. Using this modeling we find...

  9. Probing the Residual Structure in Avian Prion Hexarepeats by CD, NMR and MD Techniques

    Directory of Open Access Journals (Sweden)

    Carla Isernia

    2013-09-01

    Full Text Available Many proteins perform essential biological functions by means of regions that lacking specific organized structure exist as an ensemble of interconverting transient conformers. The characterization of such regions, including the description of their structural propensities, number of conformations and relative populations can provide useful insights. Prion diseases result from the conversion of a normal glycoprotein into a misfolded pathogenic isoform. The structures of mammal and chicken prion proteins show a similar fold with a globular domain and a flexible N-terminal portion that contains different repeated regions: octarepeats (PHGGGWGQ in mammals and hexarepeats (PHNPGY in chickens. The higher number of prolines in the hexarepeat region suggests that this region may retain a significant amount of residual secondary structure. Here, we report the CD, NMR and MD characterization of a peptide (2-HexaPY composed of two hexarepeats. We combine experimental NMR data and MD to investigate at atomic level its ensemble-averaged structural properties, demonstrating how each residue of both repeats has a different quantified PPII propensity that shows a periodicity along the sequence. This feature explains the absence of cooperativity to stabilize a PPII conformation. Nonetheless, such residual structure can play a role in nucleating local structural transitions as well as modulating intra-molecular or inter-molecular interactions.

  10. An MD-PhD program in Brazil: students’ concepts of science and of common sense

    Directory of Open Access Journals (Sweden)

    R.V. Oliveira

    2011-11-01

    Full Text Available In 1995, a pioneering MD-PhD program was initiated in Brazil for the training of medical scientists in experimental sciences at the Federal University of Rio de Janeiro. The program’s aim was achieved with respect to publication of theses in the form of papers with international visibility and also in terms of fostering the scientific careers of the graduates. The expansion of this type of program is one of the strategies for improving the preparation of biomedical researchers in Brazil. A noteworthy absence of interest in carrying out clinical research limits the ability of young Brazilian physicians to solve biomedical problems. To understand the students’ views of science, we used qualitative and quantitative triangulation methods, as well as participant observation to evaluate the students’ concepts of science and common sense. Subjective aspects were clearly less evident in their concepts of science. There was a strong concern about "methodology", "truth" and "usefulness". "Intuition", "creativity" and "curiosity" were the least mentioned thematic categories. Students recognized the value of intuition when it appeared as an explicit option but they did not refer to it spontaneously. Common sense was associated with "consensus", "opinion" and ideas that "require scientific validation". Such observations indicate that MD-PhD students share with their senior academic colleagues the same reluctance to consider common sense as a valid adjunct for the solution of scientific problems. Overcoming this difficulty may be an important step toward stimulating the interest of physicians in pursuing experimental research.

  11. Structure of Bolaamphiphile Sophorolipid Micelles Characterized with SAXS, SANS, and MD Simulations.

    Science.gov (United States)

    Manet, Sabine; Cuvier, Anne-Sophie; Valotteau, Claire; Fadda, Giulia C; Perez, Javier; Karakas, Esra; Abel, Stéphane; Baccile, Niki

    2015-10-15

    The micellar structure of sophorolipids, a glycolipid bolaamphiphile, is analyzed using a combination of small-angle X-ray scattering (SAXS), small-angle neutron scattering (SANS), and molecular dynamics (MD) simulations. Numerical modeling of SAXS curves shows that micellar morphology in the noncharged system (pHzero, while it measures about 12 Å at its cross-section, thus forming a "coffee bean"-like shape. The use of a contrast-matching SANS experiment shows that the hydrophobic component of sophorolipids is actually distributed in a narrow spheroidal region in the micellar core. These data seem to indicate a complex distribution of sophorolipids within the micelle, divided into at least three domains: a pure hydrophobic core, a hydrophilic shell, and a region of less defined composition in the axial direction of the ellipsoid. To account for these results, we make the hypothesis that sophorolipid molecules acquire various configurations within the micelle including bent and linear, crossing the micellar core. These results are confirmed by MD simulations which do show the presence of multiple sophorolipid configurations when passing from spherical to ellipsoidal aggregates. Finally, we also used Rb(+) and Sr(2+) counterions in combination with anomalous SAXS experiments to probe the distribution of the COO(-) group of sophorolipids upon small pH increase (5 < pH < 7), where repulsive intermicellar interactions become important. The poor ASAXS signal shows that the COO(-) groups are rather diffused in the broad hydrophilic shell rather than at the outer micellar/water interface. PMID:26430903

  12. The knock-down of the expression of MdMLO19 reduces susceptibility to powdery mildew (Podosphaera leucotricha) in apple (Malus domestica).

    Science.gov (United States)

    Pessina, Stefano; Angeli, Dario; Martens, Stefan; Visser, Richard G F; Bai, Yuling; Salamini, Francesco; Velasco, Riccardo; Schouten, Henk J; Malnoy, Mickael

    2016-10-01

    Varieties resistant to powdery mildew (PM; caused by Podosphaera leucotricha) are a major component of sustainable apple production. Resistance can be achieved by knocking-out susceptibility S-genes to be singled out among members of the MLO (Mildew Locus O) gene family. Candidates are MLO S-genes of phylogenetic clade V up-regulated upon PM inoculation, such as MdMLO11 and 19 (clade V) and MdMLO18 (clade VII). We report the knock-down through RNA interference of MdMLO11 and 19, as well as the complementation of resistance with MdMLO18 in the Arabidopsis thaliana triple mlo mutant Atmlo2/6/12. The knock-down of MdMLO19 reduced PM disease severity by 75%, whereas the knock-down of MdMLO11, alone or in combination with MdMLO19, did not result in any reduction or additional reduction of susceptibility compared with MdMLO19 alone. The test in A. thaliana excluded a role for MdMLO18 in PM susceptibility. Cell wall appositions (papillae) were present in both PM-resistant and PM-susceptible plants, but were larger in resistant lines. No obvious negative phenotype was observed in plants with mlo genes knocked down. Apparently, MdMLO19 plays the pivotal role in apple PM susceptibility and its knock-down induces a very significant level of resistance.

  13. ERR lasi eetrisse kõmulised reklaamid "Tallinn aitab!" / Berit-Helena Lamp

    Index Scriptorium Estoniae

    Lamp, Berit-Helena

    2011-01-01

    Eesti Rahvusringhääling edastas nii teles kui raadios pealinna abiprogrammi "Tallinn aitab!" reklaami, mille trükiversiooni on nimetatud Keskerakonna valimiskampaaniaks. ERRi ajakirjandusnõuniku Tarmu Tammerki komentaar

  14. Pro Patria advised Rüütel to stay home / Berit Teeäär

    Index Scriptorium Estoniae

    Teeäär, Berit

    2005-01-01

    Isamaaliidu juhtpoliitiku, Europa Parlamendi saadiku Tunne Kelami arvates annab president Arnold Rüütli otsus mitte sõita 9. maiks Moskvasse Eestile hea võimaluse selgitada oma ajalugu tervele maailmale

  15. Režissöör Jaini film on omasuguste seas ainus / Berit Toodo

    Index Scriptorium Estoniae

    Toodo, Berit

    2008-01-01

    Pärnu 22. dokumentaal- ja antropoloogiafilmide festivalil esilinastus india režissööri Rajele Jaini dokumentaalfilm "Silmalau üheksa liikumist". Filmis tegi oma viimase esinemise ka kuulus koreograaf Pina Bausch

  16. 基于JAVA技术的MD5加密算法的设计与实现%Design and Implementation of MD5 Algorithm Based on JAVA Technology

    Institute of Scientific and Technical Information of China (English)

    张浩华; 齐维毅; 赵子夫; 李瑶; 潘庆超

    2009-01-01

    详细描述了在数字签名、电子商务、信息加密领域中广泛应用的MD5加密算法,并针对其高效、跨平台使用,提出利用JSP与JavaBean相结合的技术方法实现MD5加密算法.该方法采用Java语言实现MD5算法,并利用JavaBean组件进行封装,通过JSP技术进行相应页面的动态展现,既简化JSP网页结构体现了Java体系的技术优势,又保证了应用系统的安全性、跨平台性和提高系统的执行效率.

  17. 一种基于MD5的近似图像检测算法研究%Research of similar images detection algorithm based on MD5

    Institute of Scientific and Technical Information of China (English)

    叶志伟; 夏彬; 王大震; 张彦超

    2010-01-01

    在WWW图像搜索引擎中,如何快速而准确地检测出近似或重复图像已经成为亟待解决的问题,提出一种基于MD5的近似图像检测算法.该算法选取图像分块灰度均值为特征,经过拉普拉斯特征值降维,矢量量化后,图像特征被转换为MD5值,然后根据生成的MD5值进行近似或重复图像检测.实验结果表明该算法是有效的.

  18. 基于NetMagic平台的MD5算法硬件加速模型%Hardware acceleration model of MD5 algorithm based on NetMagic platform

    Institute of Scientific and Technical Information of China (English)

    孟祥扬; 林琦

    2015-01-01

    针对MD5软件实现方法存在占用资源大、安全性差等缺点,提出了基于NetMagic平台的MD5硬件加速模型设计方案,并基于ModelSim和NetMagic平台对提出的非流水线与流水线硬件加速模型进行验证、分析.相比非流水线硬件加速模型,流水线硬件加速模型能提高MD5运算效率5倍,可用于网络处理器等硬件加密引擎,有效提高网络处理器等硬件设备的安全性和处理效率.

  19. Encrypt the User Password with the MD5 Algorithm in JAVA WEB System%JAVA WEB系统用MD5算法加密用户口令

    Institute of Scientific and Technical Information of China (English)

    李茂春; 王和顺

    2010-01-01

    在网络传输中,我们要确保一些敏感的数据在传输的过程中不会被篡改、截取,这就需要用加密算法对传输的信息进行加密.MD5是一种单向加密算法,其加密后的数据难以解密,所以广泛应用在各大型网站以及管理系统中用来保护用户口令安全.文章介绍了MD5加密算法的工作原理,并以实际应用为例介绍了JAVA WEB应用中的MD5加密算法.

  20. 基于MD5算法的身份鉴别技术的研究与实现%Study and Realization of Authentication Technique Based on MD5 Algorithm

    Institute of Scientific and Technical Information of China (English)

    张建伟; 李鑫; 张梅峰

    2003-01-01

    MD5报文摘要算法是一种应用广泛的身份认证算法,该文首先对数据加密技术进行了简要的概述.在剖析MD5算法工作原理的基础上,结合DES加密算法,采用加入时间戳、绑定IP地址的基于MD5文摘算法的一次一密方法,给出一个对访问用户口令加密的安全实现,并成功地应用于某高校"艺术类远程招生与考试管理系统".

  1. The Design of Identity Authentication Scheme of Network Examination Based on MD5 and RSA Algorithm%基于MD5和 RSA 算法的网络考试身份认证方案设计

    Institute of Scientific and Technical Information of China (English)

    许永达

    2013-01-01

      Establishing a good identity authentication system is one of the key steps to realize the network examination security ,and tradi-tional identity authentication methods like “username + password” have a big security risk .So an identity authentication scheme based on MD5 and RSA Algorithm is proposed ,which uses the MD5 algorithm to improve the“username + password” authentication method ,and then uses the digital signature based on MD5 and RSA algorithm to further verify the user’s identity .This scheme can effectively confirm us-er identity ,and greatly enhance the safety performance of the examination system .%  建立完善的身份认证系统是实现网络考试安全的关键步骤之一,而“用户名+密码”等传统身份认证方式存在较大的安全隐患。文章提出了一种基于MD5和RSA算法的身份认证方案,先利用MD5算法来改进“用户名+密码”认证方法,再借助MD5和RSA算法实现的数字签名来进一步验证用户的身份。该方案可以高效确认用户身份,极大地增强了考试系统的安全性能。

  2. MD5算法及其在电视节目技术质量控制中的应用%The Application of MD5 Algorithm in TV Program Technique Quality Control System

    Institute of Scientific and Technical Information of China (English)

    刘元春

    2010-01-01

    MD5算法是一种广泛应用的典型Hash加密算法,在详细剖析MD5算法的基础上,对其基于文件电视节目技术质量控制系统中的应用,如何解决普遍存在的文件完整性检测、密码保护、越权访问、文件重复性校验、责任追溯等安全问题进行了探索.

  3. 八棱海棠MdPPO2B基因的表达及功能分析%Expression and Functional Analysis ofMdPPO2BfromMalus robusta

    Institute of Scientific and Technical Information of China (English)

    沈雪芳; 韩晴; 高建杰; 彭日荷; 王波; 高志红; 姚泉洪; 章镇

    2015-01-01

    多酚氧化酶(PPO)是一种含多个铜离子的氧化还原酶,可催化酚类物质氧化为醌类物质。我们从八棱海棠中克隆到一个PPO的同源基因MdPPO2B,构建该基因酵母分泌表达载体并转化到毕赤酵母GS115中。SDS-PAGE电泳结果显示,表达蛋白MdPPO2B的分子量约为66.4 kDa。以邻苯二酚作为底物,该酶的最适pH和温度分别为6.5和40℃。除Cu2+、Na+、Mg2+和Li+外,4 mmol·L-1的Fe3+、Zn2+、Mn2+对酶活力表现出较强的抑制作用。在最适条件下,当苯酚浓度达600μmol·L-1时,反应4 h, MdPPO2B表达菌株可降解80%的苯酚。表明该基因在工业污水处理中具有广阔的应用潜力。%Polyphenol oxidase (PPO) is one of oxidoreductase enzymes, which catalyzes the phenols to diqui-nones. A putative PPO gene (MdPPO2B) wascloned fromMalus robusta and exogenously expressed inPichia pastoris GS115. SDS-PAGE showed thatMdPPO2B has a molecular mass of approximately 66.4 kDa. With catechol as substrate, it was showed that the optimum pH and temperature forMdPPO2B was 6.5 and 40℃, respectively. Except for Cu2+, Na+, Mg2+ and Li+, Fe3+, Zn2+ and Mn2+ inhibited the enzyme activity at a concen-tration of 4 mmol·L-1. TheMdPPO2B degraded 80% phenol after incubated for 4 h under the optimum condi-tion. In short, our original research onMdPPO2B may provide reference for the application of microorganism in industrial wastewater.

  4. 一种基于MD5硬件Key的票据号产生方法%A method of Produced Notes Number With MD5 Algorithm and IKey

    Institute of Scientific and Technical Information of China (English)

    谢琦; 杨文娜

    2009-01-01

    文章讨论了一种基于加密处理器的商业票据产生方法,介绍了采用多个母密钥片断产生MD5密钥的算法,以及密钥在加密处理器中的存储和管理方式,并给出了基于MD5算法产生票据号的实现方法和试验结果.

  5. 基于MD5算法口令鉴别系统的JAVA实现

    Institute of Scientific and Technical Information of China (English)

    刘剑鸣

    2004-01-01

    @@ MD5算法是当前美国作为非机要部门使用的数据鉴别标准.用于将任意长度的明文压缩成 128B的报文,算法可确保不同的明文不会产生相同的报文.截止到目前,世界上还未有由MD5的报文破译出明文的报道.本文介绍一种基于MD5算法口令加密和鉴别系统的JAVA实现.

  6. Steric effects on intramolecular reactivity in cyclic dipeptides: Conformational analysis validated by a combined MD/DFT approach

    Science.gov (United States)

    Lewandowska, A.; Carmichael, I.; Hörner, G.; Hug, G. L.; Marciniak, B.

    2011-08-01

    The present Molecular Dynamics (MD) simulation study addresses the geometric requirements of close-contact formation in short peptides. This process, that is probed herein by intramolecular H-atom transfer, initiated by triplet-excited ketones, demands close contact between the H-donating and H-accepting moieties. Thus, any deduction about the compound's reactivity based just on MD simulations, requires independent verification of the computed conformational preferences. In this study, a procedure was developed using diketopiperazine-linked benzophenone/tyrosine dyads. Specifically, it involves a comparison of the dyads' experimental 3J(H α-H β(a/b)) spin-spin coupling constants with the theoretical values obtained by weighting DFT-computed spin-spin coupling constants with the MD-computed probability distributions for the dyads' configurations.

  7. Screening of UV-B-induced genes from apple peels by SSH: possible involvement of MdCOP1-mediated signaling cascade genes in anthocyanin accumulation.

    Science.gov (United States)

    Peng, Ting; Saito, Takanori; Honda, Chikako; Ban, Yusuke; Kondo, Satoru; Liu, Ji-Hong; Hatsuyama, Yoshimichi; Moriguchi, Takaya

    2013-07-01

    Suppression subtractive hybridization (SSH) was employed to identify candidate genes involved in red coloration in apple peel with the ultraviolet (UV)-B-treated 'Mutsu'. After reverse Northern blotting verification, nearly 80 clones were successfully sequenced. Large portions of the expressed sequence tags (ESTs) are well characterized anthocyanin biosynthesis-related genes, such as chalcone synthase (11A5), flavonol synthase (12F3), anthocyanidin synthase (11H5) and UDP-glycosyl transferase (14A12) whose presence proved the success of SSH. Eight ESTs were selected for quantitative real-time polymerase chain reaction analysis and their expressions were all elevated in 'Induction', further confirming the reliability of the SSH library. One EST, 11F4 (CONSTITUTIVE PHOTOMORPHOGENIC 1: COP1) with putative function in light signal relay was further analyzed in 'Mutsu' and 'Tsugaru', along with MdHY5 (ELONGATED HYPOCOTYL 5: the downstream target of COP1), MdMYB22 (a possible flavonol-specific activator under the regulation of HY5, belonging to the SG7/PRODUCTION OF FLAVONOL GLYCOSIDES family) and MdMYBA. Results showed that MdCOP1, MdHY5, MdMYB22 and MdMYBA were all UV-B inducible genes and anthocyanin accumulation occurred after their increased expressions. Moreover, their expressions and anthocyanin content were enhanced under UV-B plus 17°C treatment. The presence of G box, a known consensus binding site of HY5, in the MdMYBA promoter region implicated that it could be regulated by MdHY5, which was verified by the result of the yeast one-hybrid analysis. Our data suggested that UV-B irradiation would induce the utmost upstream light signaling factor, MdCOP1, which activates MdHY5 signaling by binding to the promoter regions of MdMYBs, and finally leads to the red coloration of apple peels. PMID:23171407

  8. Diffusion of hydrocarbon in zeolite and effect due to pore topology: Neutron scattering and MD simulation studies

    Energy Technology Data Exchange (ETDEWEB)

    Mitra, S.; Sharma, V.K.; Chaplot, S.L.; Mukhopadhyay, R., E-mail: mukhop@barc.gov.in

    2014-02-17

    Highlights: • Dynamical landscape of propylene adsorbed in two different zeolites is obtained. • MD simulation indicated three different time scales for the translational motion. • Neutron scattering data correspond to one of the three different time scales. • Faster rotational motion observed in a wider energy window neutron spectrometer. • Propylene found to be in preferred orientation in ZSM5 but not in Na–Y zeolite. - Abstract: Here we report detailed dynamical landscape of propylene adsorbed in ZSM5 and Na–Y zeolites as studied by neutron scattering and molecular dynamics (MD) simulation. Separation of propylene molecule from propane in the petrochemical industry is an important issue because it is one of the most demanding energetic separation processes due to their very close relative volatilities and molecular sizes. Aim here is to investigate the correlation of the host topology towards the dynamics of guest molecules. ZSM5 zeolite is typified by a network of intersecting channels while Na–Y has a network of spherical supercages interconnected by windows. Both neutron scattering and MD simulation studies indicated that translational diffusion of propylene is more restricted in ZSM5 compared to Na–Y zeolite. Fully atomistic MD simulation studies showed that the translation involves three different time scales and rotational motion of the propylene is much faster than translation. The observed dynamics in QENS spectrometer (ΔE ∼ 200 μeV) corresponds to one of the three translational components indicated in the MD simulation. The faster rotational motion is observed in a wider energy window spectrometer (ΔE ∼ 3 meV). MD simulation results also show some interesting features like, non-isotropic rotation in ZSM5 while it has been isotropic in Na–Y zeolite. It is also found that propylene molecules prefer to orient along channels of ZSM5 zeolite.

  9. Whispered speech emotion recognition based on MD-CM-SFLA neural network%基于MD-CM-SFLA神经网络的耳语音情感识别

    Institute of Scientific and Technical Information of China (English)

    张潇丹; 包永强; 奚吉; 赵力; 邹采荣

    2012-01-01

    A molecular dynamics simulation and cloud model theory based shuffled frog leaping algorithm (MD-CM-SFLA) is proposed. In this algorithm, an individual frog is equivalent to a molecular and only the attractive force between the worst individual and the global best individual is considered. A new intermolecular force instead of the classic two-body Lennard-Jones force is adopted, and the Velocity-Verlet algorithm and a normal cloud generator are substitued for the update strategy of the shuffled frog leaping algorithm (SFLA). The population diversity and the search efficiency are effectively balanced. Then, a MD-CM-SFLA neural network is proposed through combining the MD-CM-SFLA with back propagation (BP) neural network, and it is applied to the whispered speech emotion recognition. The experimental results of whispered speech emotion recognition indicate that compared with BP neural network, the MD-CM-SFLA neural network has obvious advantages. Under the same test conditions, the average recognition rate of the MD-CM-SFLA neural network is 5.2% higher than that of BP neural network. Therefore, utilizing MD-CM-SFLA algorithm to optimize the parameters of BP neural network can obtain fast convergence velocity and good learning ability, thus providing a new idea for whispered speech emotion recognition.%提出了一种基于分子动力学模拟与云模型理论的改进混合蛙跳算法(MD-CM-SFLA).该算法将青蛙个体等效成分子,仅考虑最差个体和全局最优个体之间的吸引力,采用一种新的分子间作用力来代替两体间经典的Lennard-Jones作用力,并利用Velocity-Verlet算法和正态云发生器代替混合蛙跳算法的更新策略,有效平衡了种群的多样性和搜索的高效性.然后,将MD-CM-SFLA算法与BP神经网络相结合,设计出一种MD-CM-SFLA神经网络,并将其应用于耳语音情感识别中.耳语音情感识别结果表明,MD-CM-SFLA神经网络相对于BP神经网络具有明显的优势,在相

  10. 25 ns studies in the LHC – MD held on 14/10/2011

    CERN Document Server

    Arduini, G; Biancacci, N; Buffat, X; Dominguez, O; Iadarola, G; Métral, E; Rumolo, G; Salvant, B; Zannini, C; Roncarolo, F; Esteban Muller, JF; Höfle, W; Shaposhnikova, E; Valuch, D; Cettour-Cave, S; Kain, V; Redaelli, S; Barnes, M; Bartmann, W; Bracco, C; Goddard, B; Claudet, S; Tavian, L; Baglin, V; Bregliozzi, G; Kersevan, R; Lanza, G

    2012-01-01

    The machine development session (12 hours) was devoted to the injection of several trains of 72 bunches with nominal bunch population and 25 ns bunch spacing with the aim of injecting up to 1000 bunches/beam. This was the third of a series MD periods (in total 72 hours were requested at the beginning of the year) dedicated to electron cloud and scrubbing studies with 25 ns beams. The first one (8 hours on 26/08/2011) was lost due to a cryogenics problem. The second (12 hours) took place on 6/10/2011 and was mostly dedicated to the setting-up of the injection and of the transverse damper.

  11. Prediction of drug-packaging interactions via molecular dynamics (MD) simulations.

    Science.gov (United States)

    Feenstra, Peter; Brunsteiner, Michael; Khinast, Johannes

    2012-07-15

    The interaction between packaging materials and drug products is an important issue for the pharmaceutical industry, since during manufacturing, processing and storage a drug product is continuously exposed to various packaging materials. The experimental investigation of a great variety of different packaging material-drug product combinations in terms of efficacy and safety can be a costly and time-consuming task. In our work we used molecular dynamics (MD) simulations in order to evaluate the applicability of such methods to pre-screening of the packaging material-solute compatibility. The solvation free energy and the free energy of adsorption of diverse solute/solvent/solid systems were estimated. The results of our simulations agree with experimental values previously published in the literature, which indicates that the methods in question can be used to semi-quantitatively reproduce the solid-liquid interactions of the investigated systems.

  12. pMD-Membrane: A Method for Ligand Binding Site Identification in Membrane-Bound Proteins.

    Directory of Open Access Journals (Sweden)

    Priyanka Prakash

    2015-10-01

    Full Text Available Probe-based or mixed solvent molecular dynamics simulation is a useful approach for the identification and characterization of druggable sites in drug targets. However, thus far the method has been applied only to soluble proteins. A major reason for this is the potential effect of the probe molecules on membrane structure. We have developed a technique to overcome this limitation that entails modification of force field parameters to reduce a few pairwise non-bonded interactions between selected atoms of the probe molecules and bilayer lipids. We used the resulting technique, termed pMD-membrane, to identify allosteric ligand binding sites on the G12D and G13D oncogenic mutants of the K-Ras protein bound to a negatively charged lipid bilayer. In addition, we show that differences in probe occupancy can be used to quantify changes in the accessibility of druggable sites due to conformational changes induced by membrane binding or mutation.

  13. An novel architecture for information hiding using HMAC-MD5

    Directory of Open Access Journals (Sweden)

    Agilandeeswari Loganathan

    2013-03-01

    Full Text Available Communication in digital form has become the part of day today’s lifestyle, in certain moment communication is made secret to avoid others from knowing the information. By providing security to the sensitive data it is ensured that the user’s data is protected from viewing and accessing by others. In the current discussion about data security, Steganographic algorithm using two mediums has been discussed that involves image based encryption and converting to word file. The stage involving image based encryption uses HMAC-MD5 algorithm along with LSB steganography. LSB technique scatters the secret data which have to be protected over the entire image. Convert the embedded image in word file, so that the secret message is made unavailable to others who try to obtain the file. This method provides greater payload capacity along with higher image fidelity and thus make the proposed system is more robust against attacks. 

  14. Mary Edwards Walker, M.D.: a feminist physician a century ahead of her time.

    Science.gov (United States)

    Spiegel, A D; Suskind, P B

    1996-06-01

    In her teens, Mary Edwards Walker already wore the "bloomer" outfit began to campaign for reforming the "unhygienic" clothing of women. Assertively, she attended medical school and earned her M.D. degree. Due to prejudice, her practice did not flourish and she moved to Washington to offer her medical services to the Union as the Civil War began. Rebuffed by the male medical bureaucrats, she volunteered her services anyway. Eventually, she was awarded the Congressional Medal of Honor, the only women to ever gain such distinction. After the war, Walker became a journalist, an author of two sensational books, a political lobbyist, a suffrage campaigner, a professional and public lecturer, an ardent dress reformer, a peace activist, a Utopianist and a women's right advocate. Light-years ahead of her times, Dr. Walker was an intelligent, independent, irrepressible and indefatigable proponent for a host of worthy causes. PMID:8726211

  15. A study of QM/Langevin-MD simulation for oxygen-evolving center of photosystem II

    Energy Technology Data Exchange (ETDEWEB)

    Uchida, Waka; Kimura, Yoshiro; Wakabayashi, Masamitsu [Department of Biomolecular Engineering, Tokyo Institute of Technology, Nagatsuta, Midori-ku, Yokohama 226-8503 (Japan); Hatakeyama, Makoto; Ogata, Koji; Nakamura, Shinichiro [RIKEN Research Cluster for Innovation, Nakamura Laboratory, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan); Yokojima, Satoshi [Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan and RIKEN Research Cluster for Innovation, Nakamura Laboratory, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan)

    2013-12-10

    We have performed three QM/Langevin-MD simulations for oxygen-evolving complex (OEC) and surrounding residues, which are different configurations of the oxidation numbers on Mn atoms in the Mn{sub 4}O{sub 5}Ca cluster. By analyzing these trajectories, we have observed sensitivity of the change to the configuration of Mn oxidation state on O atoms of carboxyl on three amino acids, Glu354, Ala344, and Glu333. The distances from Mn to O atoms in residues contacting with the Mn{sub 4}O{sub 5}Ca cluster were analyzed for the three trajectories. We found the good correlation of the distances among the simulations. However, the distances with Glu354, Ala344, and Glu333 have not shown the correlation. These residues can be sensitive index of the changes of Mn oxidation numbers.

  16. AstroMD. A multi-dimensional data analysis tool for astrophysical simulations

    CERN Document Server

    Becciani, U; Gheller, C; Calori, L; Buonomo, F; Imboden, S

    2000-01-01

    Over the past few years, the role of visualization for scientific purpose has grown up enormously. Astronomy makes an extended use of visualization techniques to analyze data, and scientific visualization has became a fundamental part of modern researches in Astronomy. With the evolution of high performance computers, numerical simulations have assumed a great role in the scientific investigation, allowing the user to run simulation with higher and higher resolution. Data produced in these simulations are often multi-dimensional arrays with several physical quantities. These data are very hard to manage and to analyze efficiently. Consequently the data analysis and visualization tools must follow the new requirements of the research. AstroMD is a tool for data analysis and visualization of astrophysical data and can manage different physical quantities and multi-dimensional data sets. The tool uses virtual reality techniques by which the user has the impression of travelling through a computer-based multi-dim...

  17. MD simulation on the interactions between CH2 groups and the (001) surface of tungsten

    Institute of Scientific and Technical Information of China (English)

    Xianfu Feng; Shuping Tian; Xinkui He; Fujun Gou; Shuiquan Deng; Yong Zhao

    2014-01-01

    This work studies the angle dependence of the interactions between impinging CH2 particles of 150 eV with the tungsten surface. The simulations show that the carbon atoms are much more easily bonded to the tungsten atoms than hydrogen atoms, though a few of the latter can also penetrate into the tungsten material. When the inci-dence angle is greater than 75?, the incident CH2 particles are reflected without break-ups. Below this angle, a W–C layer of about 0.5 nm is formed with another C, H-rich layer depositing on top of it. The molecular dynamics (MD) approach has proved to be a powerful tool to solve the structural problems at atomic length scale of various materials. Some of its possible applications to the railway track materials have also been discussed.

  18. Mapping a candidate gene (MdMYB10) for red flesh and foliage colour in apple

    Science.gov (United States)

    Chagné, David; Carlisle, Charmaine M; Blond, Céline; Volz, Richard K; Whitworth, Claire J; Oraguzie, Nnadozie C; Crowhurst, Ross N; Allan, Andrew C; Espley, Richard V; Hellens, Roger P; Gardiner, Susan E

    2007-01-01

    Background Integrating plant genomics and classical breeding is a challenge for both plant breeders and molecular biologists. Marker-assisted selection (MAS) is a tool that can be used to accelerate the development of novel apple varieties such as cultivars that have fruit with anthocyanin through to the core. In addition, determining the inheritance of novel alleles, such as the one responsible for red flesh, adds to our understanding of allelic variation. Our goal was to map candidate anthocyanin biosynthetic and regulatory genes in a population segregating for the red flesh phenotypes. Results We have identified the Rni locus, a major genetic determinant of the red foliage and red colour in the core of apple fruit. In a population segregating for the red flesh and foliage phenotype we have determined the inheritance of the Rni locus and DNA polymorphisms of candidate anthocyanin biosynthetic and regulatory genes. Simple Sequence Repeats (SSRs) and Single Nucleotide Polymorphisms (SNPs) in the candidate genes were also located on an apple genetic map. We have shown that the MdMYB10 gene co-segregates with the Rni locus and is on Linkage Group (LG) 09 of the apple genome. Conclusion We have performed candidate gene mapping in a fruit tree crop and have provided genetic evidence that red colouration in the fruit core as well as red foliage are both controlled by a single locus named Rni. We have shown that the transcription factor MdMYB10 may be the gene underlying Rni as there were no recombinants between the marker for this gene and the red phenotype in a population of 516 individuals. Associating markers derived from candidate genes with a desirable phenotypic trait has demonstrated the application of genomic tools in a breeding programme of a horticultural crop species. PMID:17608951

  19. Mapping a candidate gene (MdMYB10 for red flesh and foliage colour in apple

    Directory of Open Access Journals (Sweden)

    Allan Andrew C

    2007-07-01

    Full Text Available Abstract Background Integrating plant genomics and classical breeding is a challenge for both plant breeders and molecular biologists. Marker-assisted selection (MAS is a tool that can be used to accelerate the development of novel apple varieties such as cultivars that have fruit with anthocyanin through to the core. In addition, determining the inheritance of novel alleles, such as the one responsible for red flesh, adds to our understanding of allelic variation. Our goal was to map candidate anthocyanin biosynthetic and regulatory genes in a population segregating for the red flesh phenotypes. Results We have identified the Rni locus, a major genetic determinant of the red foliage and red colour in the core of apple fruit. In a population segregating for the red flesh and foliage phenotype we have determined the inheritance of the Rni locus and DNA polymorphisms of candidate anthocyanin biosynthetic and regulatory genes. Simple Sequence Repeats (SSRs and Single Nucleotide Polymorphisms (SNPs in the candidate genes were also located on an apple genetic map. We have shown that the MdMYB10 gene co-segregates with the Rni locus and is on Linkage Group (LG 09 of the apple genome. Conclusion We have performed candidate gene mapping in a fruit tree crop and have provided genetic evidence that red colouration in the fruit core as well as red foliage are both controlled by a single locus named Rni. We have shown that the transcription factor MdMYB10 may be the gene underlying Rni as there were no recombinants between the marker for this gene and the red phenotype in a population of 516 individuals. Associating markers derived from candidate genes with a desirable phenotypic trait has demonstrated the application of genomic tools in a breeding programme of a horticultural crop species.

  20. Summary of LHC MD 398: Verification of the dependence of the BCTF measurements on beam position and bunch length

    CERN Document Server

    Krupa, Michal; Gasior, Marek; Lefevre, Thibaut; Soby, Lars; CERN. Geneva. ATS Department

    2015-01-01

    The main aim of the MD was to study the dependency of bunch-by-bunch intensity measurements to beam position and bunch length variations. Large beam position offsets in IR4 and varying bunch length were introduced to compare the performance of the presently installed Fast Beam Current Transformers with the new Integrating Current Transformer and the new Wall Current Transformer. This note explains all the procedures of the LHC MD 398, which took place on 20/07/2015, and presents the obtained results.

  1. 如何使用C + + Builder多线程技术实现MD5校验

    Institute of Scientific and Technical Information of China (English)

    陈家雄

    2007-01-01

    @@ A MD5全称是Message-Digest Algorithm 5(信息-摘要算法5),广泛用于字符串的加密和文件的校验上.比如在电信、金融等一些安全等级要求极高的系统中,大多是将用户密码转换成MD5密文后再存储在数据库系统中.

  2. MD Calculation of Ground-State Energy of the Nucleotide Doublets, Their Eigenmode Frequencies and Geometry Optimization

    CERN Document Server

    Kretov, D A

    2004-01-01

    Based on the computer molecular dynamics (MD) modeling methods we have calculated the ground-state energy and eigenvalue frequencies of the adenine-thymine and guanine-cytosine nucleotide doublets and performed their geometry optimization. We have found the eigenmodes in the infrared and radio-frequency ranges. The possibility of application of the simulation results in detection of bio-structures through the spectral analysis is considered. In the quantum chemistry MD calculations we employed the \\textit{Gaussian98} code and MOLDEN package.

  3. New SIO Masers in Star Forming Regions W:51 IRS:2 and SAGITTARIUS-B2 MD:5

    Science.gov (United States)

    Hasegawa, T.; Morita, K.; Okumura, S.; Kaifu, N.; Suzuki, H.; Ohishi, M.; Hayashi, M.; Ukita, N.

    The maser emission of the 43 GHz SiO J = 1-0 transitions in two regions of active star formation, W51 IRS2 and Sgr B2 MD5, have been detected using the 45 m telescope at Nobeyama. The SiO masers coincide in position with strong H2O masers in each region within a positional uncertainty of 5arcsec. If the masers radiate isotropically, the power radiated from W51 IRS2 and Sgr B2 MD5 in the masing 43 GHz SiO lines are comparable to that from the maser in Orion-KL.

  4. 关于MD5摘要算法认识的几个误区

    Institute of Scientific and Technical Information of China (English)

    杨清虎

    2012-01-01

    本文简单分析了人们对MD5摘要算法在碰撞随时可能发生、更换算法结构会使算法更可靠、散列值越长越安全等7个方面存在的误区,以期对MD5算法的认识和实际应用有一定的助益。

  5. Design and Implementation of a Non-pipelined MD5 Hardware Architecture Using a New Functional Description

    Science.gov (United States)

    Algredo-Badillo, Ignacio; Feregrino-Uribe, Claudia; Cumplido, René; Morales-Sandoval, Miguel

    MD5 is a cryptographic algorithm used for authentication. When implemented in hardware, the performance is affected by the data dependency of the iterative compression function. In this paper, a new functional description is proposed with the aim of achieving higher throughput by mean of reducing the critical path and latency. This description can be used in similar structures of other hash algorithms, such as SHA-1, SHA-2 and RIPEMD-160, which have comparable data dependence. The proposed MD5 hardware architecture achieves a high throughput/area ratio, results of implementation in an FPGA are presented and discussed, as well as comparisons against related works.

  6. MD5算法及其在文件系统完整性保护中的应用

    Institute of Scientific and Technical Information of China (English)

    张学旺; 唐贤伦

    2003-01-01

    MD5算法是一种应用广泛的提取数字指纹的算法.文件系统完整性保护利用MD5算法产生文件或对象的数字指纹以识别它们的微小变化而实施保护.文中详细剖析了MD5算法的工作原理,以及基于MD5算法的文件系统完整性检查程序的原理、设计和实现.

  7. The Geometry of K-Orbits of a Subclass of MD5-Groups and Foliations Formed by their Generic K-Orbits

    CERN Document Server

    Vu, L A; Vu, Le Anh; Thanh, Duong Minh

    2006-01-01

    The present paper is a continuation of Le Anh Vu's ones [13], [14], [15]. Specifically, the paper is concerned with the subclass of connected and simply connected MD5-groups such that their MD5-algebras $\\mathcal{G}$ have the derived ideal ${\\mathcal{G}}^{1} : = [ \\mathcal{G},\\mathcal{G} ]\\equiv$ ${\\bf{R}}^{3}$. We shall describe the geometry of K-orbits of these MD5-groups. The foliations formed by K-orbits of maximal dimension of these MD5-groups and their measurability are also presented in the paper.

  8. 高性能MD5算法IP核的设计空间探索与分析%Design Space Exploration and Analysis of High Performance MD5 IP Core

    Institute of Scientific and Technical Information of China (English)

    原昊; 吴东; 谢向辉

    2009-01-01

    This paper uses a high-level hardware description language called Bluespec SystemVerilog as the basic tool, takes a design space exploration of the hardware implementation of the MD5 algorithm, implements four different architec-tures, tests and analyzes the performance and area occupation of the four architectures, and gets the complete parameters of the design space for MD5 IP Cores.%本文以Bluespec SystemVerilog高层硬件描述语言为工具,对MD5核心算法进行了设计空间探索,实现了全展开组合逻辑、全展开流水线、循环迭代、流水化的循环迭代四种结构,测试和分析了各种结构的性能和面积指标,完整掌握了MD5 IP核的设计空间的各项参数.

  9. A Comparison of the American Society of Cataract and Refractive Surgery post-myopic LASIK/PRK Intraocular Lens (IOL calculator and the Ocular MD IOL calculator

    Directory of Open Access Journals (Sweden)

    Hsu M

    2011-09-01

    Full Text Available David L DeMill1, Majid Moshirfar1, Marcus C Neuffer1, Maylon Hsu1, Shameema Sikder21John A Moran Eye Center, University of Utah, Salt Lake City, UT, USA; 2Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USABackground: To compare the average values of the American Society of Cataract and Refractive Surgery (ASCRS and Ocular MD intraocular lens (IOL calculators to assess their accuracy in predicting IOL power in patients with prior laser-in-situ keratomileusis (LASIK or photorefractive keratectomy.Methods: In this retrospective study, data from 21 eyes with previous LASIK or photorefractive keratectomy for myopia and subsequent cataract surgery was used in an IOL calculator comparison. The predicted IOL powers of the Ocular MD SRK/T, Ocular MD Haigis, and ASCRS averages were compared. The Ocular MD average (composed of an average of Ocular MD SRK/T and Ocular MD Haigis and the all calculator average (composed of an average of Ocular MD SRK/T, Ocular MD Haigis, and ASCRS were also compared. Primary outcome measures were mean arithmetic and absolute IOL prediction error, variance in mean arithmetic IOL prediction error, and the percentage of eyes within ±0.50 and ±1.00 D.Results: The Ocular MD SRK/T and Ocular MD Haigis averages produced mean arithmetic IOL prediction errors of 0.57 and –0.61 diopters (D, respectively, which were significantly larger than errors from the ASCRS, Ocular MD, and all calculator averages (0.11, –0.02, and 0.02 D, respectively, all P < 0.05. There was no statistically significant difference between the methods in absolute IOL prediction error, variance, or the percentage of eyes with outcomes within ±0.50 and ±1.00 D.Conclusion: The ASCRS average was more accurate in predicting IOL power than the Ocular MD SRK/T and Ocular MD Haigis averages alone. Our methods using combinations of these averages which, when compared with the individual averages, showed a trend of decreased mean arithmetic IOL

  10. Duplicate Data Delete Technology Based on MD5 and Bloom Filter%基于MD5和布鲁姆过滤器的重复数据删除算法

    Institute of Scientific and Technical Information of China (English)

    车玉婧; 胡波; 费向东

    2011-01-01

    针对目前重复数据处理技术的低效性和不可靠性,本文提出了一种基于MD5算法和布鲁姆过滤器的重复数据删除算法。新算法采用两级布鲁姆过滤器并有效结合MDS算法的方式,在发挥布鲁姆过滤器空间效率的同时汲取了MD5算法的可靠性,使得文件级别和数据块级别的重复数据删除策略交替工作。测试分析表明,新算法性能稳定并且实现了高效且可靠的重复数据删除功能。%Aimed at the inefficiency and unreliability of the data de-duplication teclmology, a solution to this problem which based on MD5 algorithm and Bloom Filter technology is put forward in this paper.The new algorithm is the effective combination of MD5 algorithm and Bloom Filter structure.Profiting from less space occupancy of Bloom Filter and reliability of MD5 algorithm,the new algorithm can work under the alternate mode of file-level data de-duplication tactic and data-block-level data de-duplication tactic.Testing and analysis indicate that the new algorithm has achieved an efficient and secure data de-duplication function.

  11. A TLR4/MD2 fusion protein inhibits LPS-induced pro-inflammatory signaling in hepatic stellate cells

    International Nuclear Information System (INIS)

    Activated hepatic stellate cells (HSCs) play a key role in hepatic fibrogenesis. In injured liver they are the main extracellular matrix protein producing cell type and further perpetuate hepatic injury by secretion of pro-inflammatory mediators. Since LPS-mediated signaling through toll-like receptor 4 (TLR4) has been identified as key fibrogenic signal in HSCs we aimed to test TLR4 as potential target of therapy via ligand-binding soluble receptors. Incubation of human HSCs with a fusion protein between the extracellular domain of TLR4 and MD2 which binds LPS inhibited LPS-induced NFκB and JNK activation. TLR4/MD2 abolished LPS-induced secretion of IL-6, IL-8, MCP1, and RANTES in HSCs. In addition, TLR4/MD2 fused to human IgG-Fc neutralized LPS activity. Since TLR4 mutant mice are resistant to liver fibrosis, the TLR4/MD2 soluble receptor might represent a new therapeutic molecule for liver fibrogenesis in vivo

  12. Down-regulation of promoter methylation level of CD4 gene after MDV infection in MD-susceptible chicken line

    Science.gov (United States)

    Marek’s disease virus (MDV) is an oncovirus that induces lymphoid tumors in susceptible chickens, and may affect the epigenetic stability of the CD4 gene. The purpose of this study was to find how the effect of MDV infection on DNA methylation status of the CD4 gene differed between MD-resistant (L6...

  13. QM/MD studies of the dynamics of the MTSL spin label in Aurora-A kinase protein activation loop

    CERN Document Server

    Concilio, Maria Grazia; Bayliss, Richard; Burgess, Selena

    2015-01-01

    Molecular dynamics(MD)simulations using a graphics processing unit (GPU) has been employed in order to determine the conformational space of the methane-thiosulfonate spin label (MTSL) attached to the activation loop of the Aurora-A kinase protein and compared with quantum mechanical (QM) methods rooted on density functional theory (DFT). MD provided a wealth of information about interactions between the MTSL and the residues of the protein and on the different motional contributions to the overall dynamics of the MTSL. Data obtained from MD were seen to be in good agreement with those obtained from QM but the dynamics of the system revealed more interactions than those observed from QM methods. A strong correlation between the tumbling of the protein and the transitions of the X4 and X5 dihedral angles of the MTSL, was observed with a consequent effect also the distribution of the nitroxide(NO)group in the space. Theoretical EPR spectra calculated from opportunely selected MD frames showing interactions betw...

  14. Glucose Sensor MdHXK1 Phosphorylates and Stabilizes MdbHLH3 to Promote Anthocyanin Biosynthesis in Apple.

    Science.gov (United States)

    Hu, Da-Gang; Sun, Cui-Hui; Zhang, Quan-Yan; An, Jian-Ping; You, Chun-Xiang; Hao, Yu-Jin

    2016-08-01

    Glucose induces anthocyanin accumulation in many plant species; however, the molecular mechanism involved in this process remains largely unknown. Here, we found that apple hexokinase MdHXK1, a glucose sensor, was involved in sensing exogenous glucose and regulating anthocyanin biosynthesis. In vitro and in vivo assays suggested that MdHXK1 interacted directly with and phosphorylated an anthocyanin-associated bHLH transcription factor (TF) MdbHLH3 at its Ser361 site in response to glucose. Furthermore, both the hexokinase_2 domain and signal peptide are crucial for the MdHXK1-mediated phosphorylation of MdbHLH3. Moreover, phosphorylation modification stabilized MdbHLH3 protein and enhanced its transcription of the anthocyanin biosynthesis genes, thereby increasing anthocyanin biosynthesis. Finally, a series of transgenic analyses in apple calli and fruits demonstrated that MdHXK1 controlled glucose-induced anthocyanin accumulation at least partially, if not completely, via regulating MdbHLH3. Overall, our findings provide new insights into the mechanism of the glucose sensor HXK1 modulation of anthocyanin accumulation, which occur by directly regulating the anthocyanin-related bHLH TFs in response to a glucose signal in plants. PMID:27560976

  15. 75 FR 68970 - Amendment of Using Agency for Restricted Areas R-4002, R-4005, R-4006 and R-4007; MD

    Science.gov (United States)

    2010-11-10

    ... 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034... follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp... Restricted Areas R-4002, R-4005, R- 4006 and R-4007; MD AGENCY: Federal Aviation Administration (FAA),...

  16. 75 FR 65250 - Proposed Amendment of Class E Airspace and Revocation of Class E Airspace; Easton, MD

    Science.gov (United States)

    2010-10-22

    ...; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February... follows: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp... at Easton, MD. The Easton Non-Directional Beacon (NDB) has been decommissioned and new...

  17. 33 CFR 334.150 - Severn River at Annapolis, Md.; experimental test area, U.S. Navy Marine Engineering Laboratory.

    Science.gov (United States)

    2010-07-01

    ... Marine Engineering Laboratory. (a) The restricted area. The waters of Severn River shoreward of a line... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Severn River at Annapolis, Md.; experimental test area, U.S. Navy Marine Engineering Laboratory. 334.150 Section 334.150 Navigation...

  18. Impact of MD5 Authentication on Routing Traffic for the Case of: EIGRP, RIPv2 and OSPF

    Directory of Open Access Journals (Sweden)

    K. A. Al-Saud

    2008-01-01

    Full Text Available Problem Statement: With the free flow of routing data and the high availability of computer resources, possible threats to the networks can result in loss of privacy and in malicious use of information or resources that can eventually lead to large monetary losses. Approach: MD5 Authentication: Due to the major role that routing protocols play in computer network infrastructures, special cares has been given to routing protocols with built-in security constraints using authentication techniques, MD5 will be presented for this work. Results: The study evaluates the impact of the MD5 authentication on routing traffic for the case of EIGRP, RIPv2 and OSPF routing protocols in case of secured and non-secured routing traffic and measures the delay time, jitter and overhead. Conclusions: This study shows that the average delay time and jitter in the secured MD5 case can become significantly larger when compared to the unsecured case even in steady state conditions. Also, the EIGRP protocol shows the minimum overhead even when the system is extremely overloaded.

  19. MD Simulations of tRNA and Aminoacyl-tRNA Synthetases: Dynamics, Folding, Binding, and Allostery

    Directory of Open Access Journals (Sweden)

    Rongzhong Li

    2015-07-01

    Full Text Available While tRNA and aminoacyl-tRNA synthetases are classes of biomolecules that have been extensively studied for decades, the finer details of how they carry out their fundamental biological functions in protein synthesis remain a challenge. Recent molecular dynamics (MD simulations are verifying experimental observations and providing new insight that cannot be addressed from experiments alone. Throughout the review, we briefly discuss important historical events to provide a context for how far the field has progressed over the past few decades. We then review the background of tRNA molecules, aminoacyl-tRNA synthetases, and current state of the art MD simulation techniques for those who may be unfamiliar with any of those fields. Recent MD simulations of tRNA dynamics and folding and of aminoacyl-tRNA synthetase dynamics and mechanistic characterizations are discussed. We highlight the recent successes and discuss how important questions can be addressed using current MD simulations techniques. We also outline several natural next steps for computational studies of AARS:tRNA complexes.

  20. Multidetector CT (MD-CT) in the diagnosis of uncertain open globe injuries

    Energy Technology Data Exchange (ETDEWEB)

    Hoffstetter, P.; Schreyer, A.G.; Jung, E.M.; Heiss, P.; Zorger, N. [Inst. fuer Roentgendiagnostik, Universitaetsklinikum Regensburg (Germany); Schreyer, C.I.; Framme, C. [Klink und Poliklinik fuer Augenheilkunde, Universitaetsklinikum Regensburg (Germany)

    2010-02-15

    Purpose: To evaluate the significance of multislice CT for the diagnosis of uncertain penetrating globe injuries. Materials and Methods: Based on a retrospective chart review between 2002 and 2007, we identified 59 patients presenting with severe ocular trauma with uncertain rupture of the globe due to massive subconjunctival and/or anterior chamber hemorrhage. The IOP (intraocular pressure) was within normal range in all patients. High resolution multidetector CT (MD-CT) scans (16 slice scans) with axial and coronar reconstructions were performed in all patients. The affected eye was examined for signs of penetrating injury such as abnormal eye shape, scleral irregularities, lens dislocation or intravitreal hemorrhages. Four experienced radiologists read the CT scans independently. Beside the diagnosis, the relevant morphological criteria and the optimal plane orientation (axial or coronar) were specified. The sensitivity, specificity, and negative and positive predictive value were calculated. Additionally the interobserver variability was determined by applying the Cohen's kappa test. Surgical sclera inspections were performed in all cases as a standard of reference. The evaluations of the CT examination were compared with the surgery reports. Results: 59 patients were evaluated (42 men, 17 women). The mean age was 29 years (range 7-91). In 17 patients a rupture of the globe was diagnosed during surgery. 12 of these 17 penetrating injuries (70.6%) were classified correctly by MDCT, 5 of the 17 (29.4%) were not detectable. 42 patients did not have an open globe injury. 41 of these patients were diagnosed correctly negative by MDCT, and one patient was classified false positive. This results in a sensitivity of 70% with a specificity of 98%. There was high inter-rater agreement with kappa values between 0.89-0.96. Most discrepancies were caused by wrong negative findings. The most frequent morphologic criteria for open globe injury were the deformation (n

  1. [Albert Schweitzer's MD thesis on Criticism of the medical pathographies on Jesus].

    Science.gov (United States)

    Seidel, Michael

    2009-01-01

    The prominent philosopher, theologian, physician, musicologist and organ soloist Albert Schweitzer (14. 1. 1875-4. 9. 1965) submitted his MD thesis Kritik der von medizinischer Seite veröffentlichten Pathographien uber Jesus (Criticism of the medical pathographies on Jesus) in 1913. Very soon he published this work under the title Die psychiatrische Beurteilung Jesu. Darstellung und Kritik (The psychiatric evaluation of Jesus. Description and criticism) in order to reach a broader audience. Schweitzer's explicit motive for selecting this topic was to influence the theological debate by means of a M. D. thesis on psychiatric pathographies on Jesus. He was confronted with a lot of reproaches. These reproaches contended that his theological opinions had been supporting tendencies to describe Jesus as a mentally ill person or a religious fanatic. In addition, some authors of pathographies on Jesus (De Loosten, Binet-Sanglé, Hirsch, Rasmussen) characterized Jesus as mentally ill, suffering from paranoia. Schweitzer intended to reject the reproaches considering himself and the postulates of the authors of the pathographies. Schweitzer combined in a transdisciplinary way theological, psychiatric and psychopathological arguments. He did this in a very convincing way. Although Schweitzer did not deal with a central or explicit psychiatric question, he implicitly postulated transdisciplinary approaches for proper retrospective pathographies on historic persons. At the age of thirty, Schweitzer decided to finish his academic career and to begin studies in medicine as a preparation for work as a physician in Africa. This decision provoked much lack of understanding in his personal environment. Therefore it may be possible that a very personal motive contributed to the selection of the topic of the MD thesis. Among psychiatric authorities, Albert Schweitzer's interest in the criticisms of psychiatric pathographies and his transdisciplinary approach to this topic encountered

  2. Atomic level insights into realistic molecular models of dendrimer-drug complexes through MD simulations

    Science.gov (United States)

    Jain, Vaibhav; Maiti, Prabal K.; Bharatam, Prasad V.

    2016-09-01

    Computational studies performed on dendrimer-drug complexes usually consider 1:1 stoichiometry, which is far from reality, since in experiments more number of drug molecules get encapsulated inside a dendrimer. In the present study, molecular dynamic (MD) simulations were implemented to characterize the more realistic molecular models of dendrimer-drug complexes (1:n stoichiometry) in order to understand the effect of high drug loading on the structural properties and also to unveil the atomistic level details. For this purpose, possible inclusion complexes of model drug Nateglinide (Ntg) (antidiabetic, belongs to Biopharmaceutics Classification System class II) with amine- and acetyl-terminated G4 poly(amidoamine) (G4 PAMAM(NH2) and G4 PAMAM(Ac)) dendrimers at neutral and low pH conditions are explored in this work. MD simulation analysis on dendrimer-drug complexes revealed that the drug encapsulation efficiency of G4 PAMAM(NH2) and G4 PAMAM(Ac) dendrimers at neutral pH was 6 and 5, respectively, while at low pH it was 12 and 13, respectively. Center-of-mass distance analysis showed that most of the drug molecules are located in the interior hydrophobic pockets of G4 PAMAM(NH2) at both the pH; while in the case of G4 PAMAM(Ac), most of them are distributed near to the surface at neutral pH and in the interior hydrophobic pockets at low pH. Structural properties such as radius of gyration, shape, radial density distribution, and solvent accessible surface area of dendrimer-drug complexes were also assessed and compared with that of the drug unloaded dendrimers. Further, binding energy calculations using molecular mechanics Poisson-Boltzmann surface area approach revealed that the location of drug molecules in the dendrimer is not the decisive factor for the higher and lower binding affinity of the complex, but the charged state of dendrimer and drug, intermolecular interactions, pH-induced conformational changes, and surface groups of dendrimer do play an

  3. MD-1 deficiency attenuates dextran sodium sulfate (DSS)-induced colitis through modulating the function of colonic lamina propria dendritic cells.

    Science.gov (United States)

    Pan, Huaqin; Zhang, Guqin; Zhang, Lin; Wang, Wei; Shang, Jian; Wang, Xiaobing; Zhao, Qiu; Li, Jin

    2016-07-01

    Available evidence suggests that both dysregulated innate and adaptive immune pathways contribute to the aberrant intestinal inflammatory response in patients with inflammatory bowel disease (IBD). Myeloid Differentiation 1 (MD-1), also known as Lymphocyte Antigen 86 (Ly86), a secreted protein interacting with radioprotective 105 (RP105), plays an important role in Toll-like receptor 4 (TLR4) signaling pathway. Previous studies showed that MD-1 may be involved in the (patho) physiological regulation of the innate immune system and inflammation. In this study, we reported for the first time that MD-1 mRNA expression was up-regulated in both human IBD patients and DSS-treated WT mice. We showed that MD-1(-/-) mice were less susceptible to the development of colitis than WT controls as demonstrated by significantly reduced weight loss, disease activity index, colon histological scores, cellular infiltration and expression of inflammatory mediators. In addition, mucosal barrier function seemed to be intact in response to the loss of MD-1. Finally, lamina propria dendritic cells (LPDCs) from the colon of MD-1(-/-) mice after DSS exposure not only decreased in number but also significantly down-regulated the expression of surface maturation co-stimulatory molecules MHC-II, CD40 and CD86 compared with those from WT mice. Taken together, our results reveal that MD-1 deficiency is of critical importance in down-regulating induction and progression of DSS colitis, thereby suggesting that MD-1 might be a target for future interventional therapies of IBD.

  4. Is psychopathology part of the phenotypic spectrum of myoclonus-dystonia?: a study of a large Dutch M-D family

    NARCIS (Netherlands)

    E.M.J. Foncke; D. Cath; K. Zwinderman; J. Smit; B. Schmand; M. Tijssen

    2009-01-01

    AB Background: Myoclonus-dystonia (M-D) is a movement disorder frequently caused by mutations in the epsilon-sarcoglycan gene (SGCE, DYT11). In several M-D families, psychiatric symptoms accompanying the motor symptoms have been reported, but a shared genetic etiology remains unclear. Objective: To

  5. Distribution of Drug Molecules in Lipid Membranes: Neutron Diffraction and MD Simulations.

    Science.gov (United States)

    Boggara, Mohan; Mihailescu, Ella; Krishnamoorti, Ramanan

    2009-03-01

    Non-steroidal anti-inflammatory drugs (NSAIDs) e.g. Aspirin and Ibuprofen, with chronic usage cause gastro intestinal (GI) toxicity. It has been shown experimentally that NSAIDs pre-associated with phospholipids reduce the GI toxicity and also increase the therapeutic activity of these drugs compared to the unmodified ones. In this study, using neutron diffraction, the DOPC lipid bilayer structure (with and without drug) as well as the distribution of a model NSAID (Ibuprofen) as a function of its position along the membrane normal was obtained at sub-nanometer resolution. It was found that the bilayer thickness reduces as the drug is added. Further, the results are successfully compared with atomistic Molecular Dynamics simulations. Based on this successful comparison and motivated by atomic details from MD, quasi-molecular modeling of the lipid membrane is being carried out and will be presented. The above study is expected to provide an effective methodology to design drug delivery nanoparticles based on a variety of soft condensed matter such as lipids or polymers.

  6. REVIEW OF MD (ANATOMY EXAM PAPERS: IS THE PRESENT SYSTEM OF POSTGRADUATE EVALUATION ADEQUATE?

    Directory of Open Access Journals (Sweden)

    Pooja Jain

    2014-06-01

    Full Text Available An ideal education system is in-separable from the evaluation system. There has always been a need for an evaluation system which can determine whether predetermined educational objectives have been achieved. As an exercise last 10 years annual MD question papers (anatomy of university of Delhi were given to the residents and the Post graduate students of anatomy department, Lady Hardinge Medical College, New Delhi. The analysis of question papers reflected that the emphasis on different parts of the syllabi was not uniform. All the questions were of long and short essay type. Multiple choice questions that are based on recall and problem solving attitude of the students were not at all included. There is need to revise the pattern in which question are being asked that will develop cognitive skills and problem solving attitude among the students. An ideal question paper should give equal weight-age to different content areas/topics and it should include all analytical, objective, long and short answer type questions with an uniform marking scheme for all students. When it comes to medical education, evaluation becomes very important because here lays the responsibility of bringing out the best doctor amongst the best.

  7. Non-structured treatment interruptions (NTIs) among injection drug users in Baltimore, MD

    Science.gov (United States)

    Kavasery, Ravi; Galai, Noya; Astemborski, Jacquie; Lucas, Gregory M; Celentano, David D; Kirk, Gregory D; Mehta, Shruti H.

    2009-01-01

    Background We characterized patterns of highly active antiretroviral therapy (HAART) use and predictors of non-structured treatment interruptions (NTIs) among injection drug users (IDUs) in Baltimore, MD. Methods 335 IDUs who initiated HAART from 1996-2006 were studied. NTIs were defined as any subsequent six-month interval where HAART was not reported. Predictors of the first NTI and subsequent restart of HAART were examined using Cox regression. Results 260 (78%) reported ≥1 NTI. Of 215 with ≥1 follow-up visit after the NTI, 44 (20%) never restarted HAART, 62 (29%) restarted and remained on HAART and 109 (51%) reported multiple NTIs. NTIs were less likely among those who initiated HAART in later calendar years and hada recent outpatient visit and more likely among women, persons with detectable HIV RNA at the prior visit and those who reported injecting daily. Among those with NTIs, interuptions occurred earlier in persons who were younger, did not have a prior AIDS diagnosis and were actively injecting; NTIs lasted longer in persons who had higher HIV RNA levels, were incarcerated and drinking alcohol. A recent outpatient visit and not actively injecting were associated with restarting HAART. Conclusions NTIs were common in this population and occurred most frequently in the setting of active drug use and disruption of health care. Effective linkages between primary care for HIV and substance abuse treatment may improve HAART outcomes in this population. PMID:19214124

  8. QM/MD studies on graphene growth from small islands on the Ni(111) surface

    Science.gov (United States)

    Jiao, Menggai; Song, Wei; Qian, Hu-Jun; Wang, Ying; Wu, Zhijian; Irle, Stephan; Morokuma, Keiji

    2016-01-01

    the nuclei to expand the size of the growing carbon network. The growth of graphene precursors is accompanied by the corresponding changes in the bonding of nickel atoms with the precipitation of subsurface carbon atoms. This is because the carbon-carbon interaction is stronger than the nickel-carbon interaction. In the case of high carbon nucleation densities, the dominant ripening mechanism depends on different growth stages. In the initial stage, the coalescence of carbon islands takes place via the Smoluchowski ripening mechanism. In the later stage the Smoluchowski ripening process is damped owing to the higher diffusion barrier of larger clusters and the restriction of movement by self-assembled nickel step edges. The cross-linking mechanism eventually takes over by the coalescence of extended polyyne chains between graphene islands. In either case, the Ostwald ripening process is not found in our molecular dynamics simulations due to the stability of carbon-carbon bonds within the islands. These investigations should be instructive to the control of graphene growth in experiments. Electronic supplementary information (ESI) available: There are two movies showing the simulation process and they are provided in separate files. Movie S1 is the evolution of QM/MD simulations of the growth of graphene from one C13 on the Ni(111) surface for trajectory D@C13. Movie S2 is the evolution of QM/MD simulations of the growth of graphene from two C13 species on the Ni(111) surface for trajectory C@2C13. Fig. S1 shows the optimized geometries of C13-G and C13-H on the Ni(111) surface. Fig. S2 is the final structures of trajectories A-J@C13 following 400 ps QM/MD simulation for the Ni(111) + C13 system. Fig. S3 is the final structures of trajectories A-J@2C13 following 350 ps QM/MD simulation for the Ni(111) + 2C13 system. Fig. S4 shows average polygonal carbon ring populations formed during graphene growth from the Ni(111) + C13 and Ni(111) + 2C13 systems. Fig. S5 shows the

  9. QM/MM MD simulations of La(III)-phosphopeptide complexes.

    Science.gov (United States)

    Messner, Christoph B; Bonn, Günther K; Hofer, Thomas S

    2015-01-01

    Several bioanalytical enrichment techniques are based on the interactions of phosphopeptides with Ln(III) ions. In order to gain an improved understanding of these complexes and the respective ion-peptide interactions, hybrid quantum mechanics/molecular mechanics (QM/MM) molecular dynamics (MD) simulations of La(III) coordinating to the phosphopeptide VPQLEIVPNSpAEER were conducted. Simulations of di- as well as monoanionic phosphate groups were carried out. The La(III) ion and its first hydration layer, including the sidechain of the phosphoserine residue were treated quantum mechanically at RI-MP2/triple zeta level, whereas the remaining part of the system was treated with classical potentials. The simulation of the dianionic phosphopeptide revealed a 9-fold coordinated La(III) ion, with the phosphopeptide binding bi- as well as monodentate. The mean residence times (τ) of the first shell water molecules were 82 ps and 37 ps for the bi- and monodentate complexes, respectively, which is much higher compared to free La(III) in aqueous solution (τ=17 ps). The simulation of the monoanionic La(III)-phosphopeptide complex revealed a bidentate coordination throughout the 80 ps sampling period. An intramolecular hydrogen bond between the hydrogen of the phosphate group and the backbone was observed and a τ value of 14 ps was obtained, which is much lower as for the dianionic complex.

  10. Implementace a testování hashovacího algoritmu MD5

    OpenAIRE

    Legéň, Michal

    2008-01-01

    Hashovací funkce jsou jedním ze základních stavebních prvků moderní kryptografie. Jejich úkolem je pro vstupní zprávy vytvářet unikátní bitové posloupnosti, nazývané digitální otisky. Tím zabezpečují nezbytnou integritu zpráv, protože data přenášena přes různá přenosová média mohou být během přenosu pozměněna. Zároveň z důvodu jednosměrnosti poskytují možnost rychlého a účinného šifrování hesel. Cílem této bakalářské práce je analyzovat jednu z nejznámějších hashovacích funkcí MD5, implemento...

  11. MD-simulations of Beta-Amyloid Protein Insertion Efficiency and Kinetics into Neuronal Membrane Mimics

    Science.gov (United States)

    Qiu, Liming; Buie, Creighton; Vaughn, Mark; Cheng, Kwan

    2011-03-01

    Early interaction events of beta-amyloid (A β) peptides with the neuronal membranes play a key role in the pathogenesis of Alzheimer's disease. We have used all-atom MD simulations to study the protein insertion efficiency and kinetics of monomeric A β40 and A β42 into phosphatidylcholine lipid bilayers (PC) with and without 40 mole% cholesterol (CHOL) that mimic the cholesterol-enriched and depleted lipid nanodomains of the neuronal plasma membranes. Independent replicates of 200-ns simulations of each protein pre-inserted in the upper lipid layer were generated. In PC bilayers, only 25% of A β40 and 50% of A β42 in the replicates showed complete insertion into the lower lipid layer, whereas the percentages increased to 50% and 100%, respectively, in PC/CHOL bilayers, providing evidence that cholesterol improves the protein insertion efficiency into the bilayers. The rate of protein insertion was proportional to the hydrophobic, transmembrane helix length of the inserted peptide and depended on the cholesterol content. We propose that the lysine snorkeling and C-terminus anchoring of A β to the PC headgroups at the upper and lower lipid/water interfaces represent the dual-transmembrane stabilization mechanisms of A β in the neuronal membrane domains.

  12. Presentation of the 2007 Richard S. Hodes, M.D. Honor Lecture Award

    International Nuclear Information System (INIS)

    Perma-Fix Environmental Services, Inc. Chief Operating Officer Larry McNamara is the 2007 recipient of the distinguished Richard S. Hodes, M.D. Honor Lecture Award from the Southeast Compact Commission for Low-Level Radioactive Waste Management. This award recognizes Mr. McNamara's innovation in the commercialization of mixed waste treatment processes for the nuclear industry, and the significant role that these innovations have played solving low-level radioactive waste (LLRW) management problems in the United States with specific emphasis on low-level mixed wastes. Low-level mixed wastes (LLMW) have historically been the most difficult wastes to treat because of the specialized equipment, permits and experience needed to deal with a large variety of hazardous constituents. Prior to innovations in the mixed waste treatment industry championed by Mr. McNamara, wastes were stored at generator sites around the country in regulated storage areas, at great cost, and in many cases for decades. In this paper, Mr. McNamara shares lessons he has learned over the past seven years in developing and implementing innovative waste management solutions that have helped solve one of the nation's biggest challenges. He also describes the future challenges facing the industry. (authors)

  13. The Study of Detecting Replicate Documents Using MD5 Hash Function

    Directory of Open Access Journals (Sweden)

    Pushpendra Singh Tomar

    2011-12-01

    Full Text Available A great deal of the Web is replicate or near- replicate content. Documents may be served in different formats: HTML, PDF, and Text for different audiences. Documents may get mirrored to avoid delays or to provide fault tolerance. Algorithms for detecting replicate documents are critical in applications where data is obtained from multiple sources. The removal of replicate documents is necessary, not only to reduce runtime, but also to improve search accuracy. Today, search engine crawlers are retrieving billions of unique URL’s, of which hundreds of millions are replicates of some form. Thus, quickly identifying replicate detection expedites indexing and searching. One vendor’s analysis of 1.2 billion URL’s resulted in 400 million exact replicates found with a MD5 hash. Reducing the collection sizes by tens of percentage point’s results in great savings in indexing time and a reduction in the amount of hardware required to support the system. Last and probably more significant, users benefit by eliminating replicate results. By efficiently presenting only unique documents, user satisfaction is likely to increase.

  14. The Study of Detecting Replicate Documents Using MD5 Hash Functio

    Directory of Open Access Journals (Sweden)

    Mr. Pushpendra Singh Tomar

    2011-09-01

    Full Text Available A great deal of the Web is replicate or near- replicate content. Documents may be served in different formats: HTML, PDF, and Text for different audiences. Documents may get mirrored to avoid delays or to provide fault tolerance. Algorithms for detecting replicate documents are critical in applications where data is obtained from multiple sources. The removal of replicate documents is necessary, not only to reduce runtime, but also to improve search accuracy. Today, search engine crawlers are retrieving billions of unique URL’s, of which hundreds of millions are replicates of some form. Thus, quickly identifying replicate detection expedites indexing and searching. One vendor’s analysis of 1.2 billion URL’s resulted in 400 million exact replicates found with a MD5 hash. Reducing the collection sizes by tens of percentage point’s results in great savings in indexing time and a reduction in the amount of hardware required to support the system. Last and probably more significant, users benefit by eliminating replicate results. By efficiently presenting only unique documents, user satisfaction is likely to increase.

  15. Modeling and imaging land-cover influences on air temperature in and near Baltimore, MD

    Science.gov (United States)

    Heisler, Gordon M.; Ellis, Alexis; Nowak, David J.; Yesilonis, Ian

    2016-04-01

    Over the course of 1681 hours between May 5 and September 30, 2006, air temperatures measured at the 1.5-m height at seven sites in and near the city of Baltimore, MD were used to empirically model Δ widehat{T} R-p , the difference in air temperature between a site in downtown Baltimore and the six other sites. Variables in the prediction equation included difference between the downtown reference and each of the other sites in upwind tree cover and impervious cover as obtained from 10-m resolution geographic information system (GIS) data. Other predictor variables included an index of atmospheric stability, topographic indices, wind speed, vapor pressure deficit, and antecedent precipitation. The model was used to map predicted hourly Δ widehat{T} R-p across the Baltimore region based on hourly weather data from the airport. Despite the numerous sources of variability in the regression modeling, the method produced reasonable map patterns of Δ widehat{T} R-p that, except for some areas evidently affected by sea breeze from the Chesapeake, closely matched results of mesoscale modeling. Potential applications include predictions of the effect of changing tree cover on air temperature in the area.

  16. Leo Eitinger MD: tribute to a Holocaust survivor, humane physician and friend of mankind.

    Science.gov (United States)

    Chelouche, Tessa

    2014-04-01

    Born in Czechoslovakia, psychiatrist Leo Eitinger (1912-1996) became internationally recognized for research on his fellow concentration camp inmates. He graduated as an MD in 1937, but being Jewish was prohibited from practicing as a doctor. When the Nazis occupied the area he was forced to flee to Norway, where in 1940 he was again deprived of his right to practice medicine. In 1942 he was arrested and deported to Auschwitz. There, as a physician inmate, he was able to help and in many cases save his fellow prisoners, not only with his medical skills but by falsifying prisoners' documents and hiding them from their Nazi captors. One of his patients was Elie Wiesel. Eitinger survived the camps but was forced to join a "death march." After the war he resumed medical practice in Norway, specializing in psychiatry. With his personal experience and knowledge of the suffering of camp survivors, he dedicated his life to studying the psychological effects of traumatic stress in different groups. Eitinger's academic contributions were crucial in the development of this area of research--namely, the effects of excessive stress, laying the foundations for the definition of post-traumatic stress disorder and the post-concentration camp syndrome, thus facilitating recognition of the medical and psychological post-war conditions of the survivors and their resultant disability pensions. PMID:24834755

  17. MD/MBA Students: An Analysis of Medical Student Career Choice

    Directory of Open Access Journals (Sweden)

    Windsor Westbrook Sherrill, Ph.D., MBA

    2004-01-01

    Full Text Available Background: An increasing number of medical schools are offering dual degree MD/MBA programs. Career choices and factors influencing students to enter these programs provide an indicator of the roles in which dual degree students will serve in health care as well as the future of dual degree programs. Purpose: Using career choice theory as a conceptual framework, career goals and factors influencing decisions to enter dual degree programs were assessed among dual degree medical students. Methods: Students enrolled at dual degree programs at six medical schools were surveyed and interviewed. A control group of traditional medical students was also surveyed. Results: Factors influencing students to seek both medical and business training are varied but are often related to a desire for leadership opportunities, concerns about change in medicine and job security and personal career goals. Most students expect to combine clinical and administrative roles. Conclusions: Students entering these programs do so for a variety of reasons and plan diverse careers. These findings can provide guidance for program development and recruitment for dual degree medical education programs

  18. MD/MBA Students: An Analysis of Medical Student Career Choice

    Directory of Open Access Journals (Sweden)

    Windsor Westbrook Sherrill, Ph.D., MBA

    2004-01-01

    Full Text Available Background: An increasing number of medical schools are offering dual degree MD/MBA programs. Career choices and factors influencing students to enter these programs provide an indicator of the roles in which dual degree students will serve in health care as well as the future of dual degree programs. Purpose: Using career choice theory as a conceptual framework, career goals and factors influencing decisions to enter dual degree programs were assessed among dual degree medical students. Methods: Students enrolled at dual degree programs at six medical schools were surveyed and interviewed. A control group of traditional medical students was also surveyed. Results: Factors influencing students to seek both medical and business training are varied but are often related to a desire for leadership opportunities, concerns about change in medicine and job security and personal career goals. Most students expect to combine clinical and administrative roles. Conclusions: Students entering these programs do so for a variety of reasons and plan diverse careers. These findings can provide guidance for program development and recruitment for dual degree medical education program

  19. Simplified MD-LSD demapping algorithm for BICM-ID systems with multi-dimensional mappings%多维映射BICM-ID系统的简化MD-LSD解映射算法

    Institute of Scientific and Technical Information of China (English)

    宫丰奎; 葛建华; 王勇

    2008-01-01

    将二维映射下的软输入软输出解映射MAX-LOG-MAP算法扩展到多维映射比特交织编码调制及迭代译码(BICM-ID)系统,并首次结合多天线系统下的列表球形译码,提出一种简化MD-LSD(multi-dimensional list sphere decoding)算法.新算法大幅降低了多维解映射的计算复杂度.仿真结果表明,列表长度满足一定范围时,采用简化MD-LSD算法解映射算法的性能损失可以忽略.

  20. Research on Security Application of MD5 Algorithm in Web System%MD5算法在Web系统中的安全性应用研究

    Institute of Scientific and Technical Information of China (English)

    杨玉军; 杨夷梅

    2009-01-01

    安全问题是基于Web系统普遍存在的问题,也是一个很难解决的问题,该文对目前的Web系统面临的安全问题进行了分析,介绍了MD5算法,把MD5算法应用于Web系统中,解决了目前Web系统普通存在的密码保护、信息完整性和越权访问等安全问题,并给出了具体实现方法,最终达到构建更安全的Web系统的目的.

  1. MD5 Algorithm in Data Security and Safety of the Application%MD5算法在数据安全中的应用及安全性分析

    Institute of Scientific and Technical Information of China (English)

    孙维国; 李浩然

    2010-01-01

    随着互联网技术的发展,数据的安全性、可用性和完整性保护已经变得越来越重要.MD5算法是在计算机安全领域广泛使用的一种散列函数,可以为任意长度的报文产生一段等长的信息摘要,并且具有单向加密的特性.本文分析了MD5算法的工作原理及其在数据安全中的应用,对其安全性进行了分析,并提出了一些改进的方案.

  2. 基于 MD5 数据库加密算法在综合业务平台中的应用研究%MD5 Encryption Algorithm Based on the Database Business in the Composite Application Platform

    Institute of Scientific and Technical Information of China (English)

    刘晓楠; 严承华

    2008-01-01

    对基于 MD5 和 Blowfish 加密算法的数据库进行了研究,首先对数据库加密系统结构进行了分析,然后利用MD5 加密算法对用户密码字段进行加密,利用 Blowfish 加密算法对存储在数据库巾的敏感数据进行加密,通过在综合业务平台中的应用表现,能够使加/解密过程不影响数据库运行性能,州时提高了数据库的安全性能.

  3. 基于MD5算法和Logistic映射的图像加密方法研究%Image Encryption Algorithm Based on MD5 Algorithm and Logistic Map

    Institute of Scientific and Technical Information of China (English)

    李进; 徐红

    2011-01-01

    文章提出一种基于MD5算法和Logistic映射新的图像加密方法,首先通过Logistic映射和MD5算法生成像素位置置乱表,由位置置乱表对图像进行位置置乱;然后利用Logistic映射生成二维混沌矩阵,通过混沌矩阵对图像进行灰度置乱.实验结果表明,该方法能有效地实现图像加密,并对密钥有较强的敏感性,抵御攻击的能力强.

  4. 迹相异Pn矩阵集的构造与MD[Pn]值的确定%On construction of Pn matrix-gather with different-trace and establishment of MD[Pn

    Institute of Scientific and Technical Information of China (English)

    郑玉歌; 郝勤道; 郑玉敏

    2000-01-01

    研究了Pn矩阵类中迹相异Pn矩阵集的构造与MD[Pn]值的确定,给出了下列最新研究结果:(1)各类Pn矩阵对角线元素的分布规律;(2)迹相异Pn矩阵全集的构造理论;(3)迹相异Pn矩阵数目的计算公式.

  5. The application and implementatio of MD5 encryption algorithm in the anthentication of the user management system based on LDAP%MD5算法在统一用户管理系统中身份认证的应用

    Institute of Scientific and Technical Information of China (English)

    郑之华

    2012-01-01

    This paper describes the MD5 encryption algorithm and its working principle, puts forward the application and implementatio of MD5 encryption algorithm in the anthentication of the user management system based on LDAP, and suggestions for improvement ideas.%介绍了MD5加密算法及其工作原理,提出了MD5在基于LDAP的统一用户管理系统中身份认证的应用和实现,并提出了改进思想。

  6. A Preliminary Analysis of the Theoretical and Application Value of the MD--EW Framework Based Classroom%浅析MD-EW架构课堂的理论及应用价值

    Institute of Scientific and Technical Information of China (English)

    秦帅

    2011-01-01

    Students and teachers always use interactive electronie whiteboard and smart mobile devices at the same time. So people think about some new teaching methods both include interactive electronic whiteboard and smart mobile devices MD-EW (Mobile Device Electronic Whiteboard)framework is increasingly feasible for us to build a new type of classroom, which has a central device- electronic whiteboard and some other interactive tools-smart mobile devices. This classroom will be an expansion of the traditional classroom,and it shows some ideas of mobile learning. Through analysis we can see that it is a good try of conjunctive use of electronic whiteboard and mobile devices.%电子白板和移动设备的使用时常发生交汇,引发了人们对新型教学应用技巧的思考。以电子白板为教学服务核心,使用移动设备作为学生端交互工具的新型课堂架构(MD-EW架构)应运而生。MD-EW架构的课堂实现了从传统课堂到微型移动课堂的扩展,体现了泛在学习和移动学习的理念,是电子白板与智能移动设备联合应用的一次有益尝试。

  7. MD5算法在J2EE平台下用户管理系统中的应用%Application of MD5 algorithm based on J2EE in user management system

    Institute of Scientific and Technical Information of China (English)

    王金柱; 李元诚

    2008-01-01

    MD5是目前在加密领域应用最为广泛的哈希函数.通过研究基于J2EE平台和B/S模式的用户管理系统的基本原理和实现方法,详细说明了基于MVC架构的系统模型,具体阐述了基于MD5进行口令密码校验的原理以及基于Java语言的算法实现.在设计口令密码校验过程中,描述了如何基于Servlet技术生成目前十分流行的图形认证码的方法.最后探讨了应用MD5算法加强Web应用中安全机制的方法和策略.

  8. Investigation of spreading characteristics of nano-droplet on solid substrate using MD simulations

    Science.gov (United States)

    Sedighi, Nahid

    Surface wettability and spreading of liquid droplets on solid surfaces are of significant fundamental and practical importance in various fields of science and technology, ranging from classical coating and spray systems to the modern micro and nanofluidic devices, and biotechnology. Due to the complexity of solid/liquid/vapor interfaces, there are still difficulties in accurately predicting the behavior of liquid droplets on solid surfaces. Droplet spreading on a surface represents a multi-scale phenomenon with scales ranging from continuum to molecular. In this thesis, molecular dynamics (MD) simulations have been employed to investigate wetting and spreading characteristics of a nanodroplet on solid surfaces. The work focuses on the development of correlations and scaling laws to examine the effect of droplet size on the spreading characters. The dynamic spreading of an initially spherical liquid droplet in contact with a solid surface and surrounded by ambient gas has been studied under forced and spontaneous spreading. An efficient algorithm has been developed to track the liquid-phase interface and the dynamic contact angle. The algorithm was demonstrated to reproduce the entire wetting regime by varying the solid-liquid interaction energy parameters. Extensive simulations have been performed to investigate the effects of surface and liquid droplet characteristics on the wetting phenomena and contact angle. In the first set of the simulations, liquid droplet, solid surface and ambient gas were modeled using argon atoms. The next set of simulations was performed using more realistic potential functions to simulate water SVS-B molecules for liquid, silicon crystal for solid surface, and nitrogen molecules for the ambient gas. Results for the argon droplet indicate a highly complex relationship between the contact angle and surface and liquid parameters. The spreading behavior was analyzed in terms of the temporal evolution of the dynamic contact angle and

  9. A QM/MM-MD study on protein electronic properties: Circular dichroism spectra of oxytocin and insulin

    Energy Technology Data Exchange (ETDEWEB)

    Kitagawa, Yuya [Graduate School of System Informatics, Kobe University, Kobe 657-8501 (Japan); CREST, Japan Science and Technology Agency (JST), 4-1-8 Honcho Kawaguchi, Saitama 332-0012 (Japan); Akinaga, Yoshinobu [RIKEN Advanced Institute for Computational Science, Kobe 650-0047 (Japan); Kawashima, Yukio [Department of Chemistry, Graduate School of Sciences, Kyushu University, Fukuoka 812-8581 (Japan); Institute of Advanced Research, Kyushu University, Fukuoka 812-8581 (Japan); Jung, Jaewoon [RIKEN Advanced Institute for Computational Science, Kobe 650-0047 (Japan); Ten-no, Seiichiro, E-mail: tenno@cs.kobe-u.ac.jp [Graduate School of System Informatics, Kobe University, Kobe 657-8501 (Japan); CREST, Japan Science and Technology Agency (JST), 4-1-8 Honcho Kawaguchi, Saitama 332-0012 (Japan)

    2012-06-05

    A QM/MM (quantum-mechanical/molecular-mechanical) molecular-dynamics approach based on the generalized hybrid-orbital (GHO) method, in conjunction with the second-order perturbation (MP2) theory and the second-order approximate coupled-cluster (CC2) model, is employed to calculate electronic property accounting for a protein environment. Circular dichroism (CD) spectra originating from chiral disulfide bridges of oxytocin and insulin at room temperature are computed. It is shown that the sampling of thermal fluctuation of molecular geometries facilitated by the GHO-MD method plays an important role in the obtained spectra. It is demonstrated that, while the protein environments in an oxytocin molecule have significant electrostatic influence on its chiral center, it is compensated by solvent induced charges. This gives a reasonable explanation to experimental observations. GHO-MD simulations starting from different experimental structures of insulin indicate that existence of the disulfide bridges with negative dihedral angles is crucial.

  10. A QM/MM-MD study on protein electronic properties: Circular dichroism spectra of oxytocin and insulin

    Science.gov (United States)

    Kitagawa, Yuya; Akinaga, Yoshinobu; Kawashima, Yukio; Jung, Jaewoon; Ten-no, Seiichiro

    2012-06-01

    A QM/MM (quantum-mechanical/molecular-mechanical) molecular-dynamics approach based on the generalized hybrid-orbital (GHO) method, in conjunction with the second-order perturbation (MP2) theory and the second-order approximate coupled-cluster (CC2) model, is employed to calculate electronic property accounting for a protein environment. Circular dichroism (CD) spectra originating from chiral disulfide bridges of oxytocin and insulin at room temperature are computed. It is shown that the sampling of thermal fluctuation of molecular geometries facilitated by the GHO-MD method plays an important role in the obtained spectra. It is demonstrated that, while the protein environments in an oxytocin molecule have significant electrostatic influence on its chiral center, it is compensated by solvent induced charges. This gives a reasonable explanation to experimental observations. GHO-MD simulations starting from different experimental structures of insulin indicate that existence of the disulfide bridges with negative dihedral angles is crucial.

  11. MD456: Monitoring of abort gap population with diamond particle detectors at the BGI in IP 4

    CERN Document Server

    Stein, Oliver

    2016-01-01

    In this MD, diamond based particle detectors (dBLM) were used for measuring showers of the beam interactions with the in the BGI induced neon gas. This setup was proposed in a feasibility study for using dBLMs at the BGI to measure the abort gap population by detecting the beam gas interactions. During the MD neon gas was induced in the BGI vacuum chamber to increase the interaction rate. Two nominal bunches were injected and accelerated up to 6.5 TeV. The measurements lasted for 140 minutes. The bunches could be clearly identified. But the resulting count rate of the beam gas interactions was a factor 70 lower than predicted by the feasibility study. In addition, a problem with the timing information lead to a widening of the histogram peaks.

  12. PUPIL: A Software Integration System for Multi-Scale QM/MM-MD Simulations and Its Application to Biomolecular Systems.

    Science.gov (United States)

    Torras, Juan; Roberts, Benjamin P; Seabra, Gustavo M; Trickey, Samuel B

    2015-01-01

    PUPIL (Program for User Package Interfacing and Linking) implements a distinctive multi-scale approach to hybrid quantum mechanical/molecular mechanical molecular dynamics (QM/MM-MD) simulations. Originally developed to interface different external programs for multi-scale simulation with applications in the materials sciences, PUPIL is finding increasing use in the study of complex biological systems. Advanced MD techniques from the external packages can be applied readily to a hybrid QM/MM treatment in which the forces and energy for the QM region can be computed by any of the QM methods available in any of the other external packages. Here, we give a survey of PUPIL design philosophy, main features, and key implementation decisions, with an orientation to biomolecular simulation. We discuss recently implemented features which enable highly realistic simulations of complex biological systems which have more than one active site that must be treated concurrently. Examples are given.

  13. Structure and dynamics of La(III) in aqueous solution An ab initio QM/MM MD approach

    Science.gov (United States)

    Hofer, Thomas S.; Scharnagl, Harald; Randolf, Bernhard R.; Rode, Bernd M.

    2006-08-01

    Ab initio QM/MM MD simulations have allowed to clarify some of the ambiguities arising from various studies on the hydrated La(III) ion. Both nine- and ten-coordinated hydrates co-exist and interchange in a dissociative process on the nano- or even subnanosecond scale, and thus much faster than any other trivalent main group or transition metal ions. The weak ion-ligand bond (53 N/m) supplies a reasonable explanation for it. The simulation results for La(III) are also compared to those for the isoelectronic ions Cs(I) and Ba(II) obtained by the same ab initio MD procedure, leading to conclusions on the influence of central ion charge on structural and dynamic properties of hydrate complexes.

  14. House M.D.: the monitoring of life, crime and disease in the age of its technical visuality

    Directory of Open Access Journals (Sweden)

    Ivana Bentes

    2011-12-01

    Full Text Available When the body, the subjectivity and disease are converted into medical information, statistics and ballistics, MRI, contrasts, maps and images, they appear as new actors and dramatic elements in contemporary fiction, especially in series as House M.D. and CSI. In this article, we analyze some House M.D. episodes, highlighting how these body visualization technologies, genetic mapping, diagnostics, monitoring procedures, equipment for production of evidences of every kind (medical and criminal are co-actors in these dramas. Technological devices and information surpass the experts’ domain and turn into a new form of entertainment, becoming vital games that mobilize specialists and amateurs. In these games we see a gradual status change from the patient or the victim, turned into participant, inter-actor, and co-director of his disease, his suffering or his crime.

  15. Comparing medical knowledge of osteopathic medical trainees in DO and MD programs: a random effect meta-analysis.

    Science.gov (United States)

    Shen, L; Cavalieri, T; Clearfield, M; Smoley, J

    1997-06-01

    The authors used random effect meta-analysis to synthesize eight mean score differences of the Part III/Level 3 examinations of the national Board of Osteopathic Medical Examiners (NBOME) between osteopathic medical trainees in DO residency programs and osteopathic medical trainees in MD programs. The analysis involved 6001 trainees and all Part III or Level 3 examinations since 1992. The average mean score difference was not significantly different from zero; however, the estimates of true effect sizes of each examination varied substantially. The findings indicate that, overall, medical knowledge of osteopathic trainees in MD and DO residency programs is compatible at the time they took the examinations. However, a large variation of effect size suggests the need for further investigation of the factors other than difference between osteopathic and allopathic training programs.

  16. Detection of the bovine viral diarrhoea / mucosal disease (BVD/MD virus in tissues from aborted ruminant foetuses using immunohistochemistry

    Directory of Open Access Journals (Sweden)

    S.M. Njiro

    2009-05-01

    Full Text Available Various tissues from aborted ruminant foetuses were collected, fixed in formalin and embedded in paraffin wax. Sections were made and exposed to a primary monoclonal antibody against the bovine viral diarrhoea / mucosal disease (BVD/MD virus, and subsequently to a goat anti-mouse secondary antibody conjugated to horse radish peroxidase (HRP. Diaminobenzidine (DAB was the substrate and it released a brown pigment in the tissues on reacting with the HRP in an immunohistochemistry (IHC procedure. Of 27 aborted foetuses, an immunoperoxidase staining reaction was observed in 1 ovine and 5 bovine foetuses. The IHC procedure located BVD/MD viral antigen in a wide variety of foetal tissues including cerebral cortical neurons, the pseudostratified columnar epithelial cells lining the bronchi, alveolar lining cells and alveolar macrophages, hepatocytes, renal tubular lining cells and the Purkinje fibres in the myocardium.

  17. MD5报文摘要算法与IPv6认证%MESSAGE DIGEST 5 AND THE AUTHENTICATION IN IPv6

    Institute of Scientific and Technical Information of China (English)

    王贵竹; 李津生; 洪佩琳

    2001-01-01

    Message digest 5 is a widely used algorithm, which can extract finger-print from message. The keyed MD5 is the default authentication algorithm in IPv6. In this paper, IPv6 header format and authentication header format are studied and the principle of MD5 is carefully analyzed. The authentication mechanism using MD5 in IPv6 is also studied in this paper.%MD5报文摘要算法是一种应用广泛的提取数字指纹的算法.在IPv6中定义带密钥的MD5算法为其默认的认证算法.本文分析了IPv6的基本头标和认证头标的格式,详细剖析了MD5算法的工作原理,以及在IPv6中引入MD5作为其默认认证算法的方法.

  18. Ionization dynamics of the water trimer: A direct ab initio MD study

    Energy Technology Data Exchange (ETDEWEB)

    Tachikawa, Hiroto, E-mail: hiroto@eng.hokudai.ac.jp [Division of Materials Chemistry, Graduate School of Engineering, Hokkaido University, Kita-ku, Sapporo 060-8628 (Japan); Takada, Tomoya [Department of Material Chemistry, Asahikawa National College of Technology, Syunkodai, Asahikawa 071-8142 (Japan)

    2013-03-29

    Highlights: ► We calculated ionization dynamics of water trimer. ► Direct ab initio molecular dynamics (MD) method is applied. ► Proton transfer dynamics were discussed. ► The proton transfer process calculated are well reproduced in recent experiments. - Abstract: Ionization dynamics of the cyclic water trimer (H{sub 2}O){sub 3} have been investigated by means of direct ab initio molecular dynamics (AIMD) method. Two reaction channels, complex formation and OH dissociation, were found following the ionization of (H{sub 2}O){sub 3}. In both channels, first, a proton was rapidly transferred from H{sub 2}O{sup +} to H{sub 2}O (time scale is ∼15 fs after the ionization). In complex channel, an ion–radical contact pair (H{sub 3}O{sup +}–OH) solvated by the third water molecule was formed as a long-lived H{sub 3}O{sup +}(OH)H{sub 2}O complex. In OH dissociation channel, the second proton transfer further takes place from H{sub 3}O{sup +}(OH) to H{sub 2}O (time scale is 50–100 fs) and the OH radical is separated from the H{sub 3}O{sup +}. At the same time, the OH dissociation takes place when the excess energy is efficiently transferred into the kinetic energy of OH radical. The OH dissociation channel is significantly minor, and almost all product channels were the complex formation. The reaction mechanism was discussed on the basis of theoretical results.

  19. Hygrosopicity measurements of aerosol particles in the San Joaquin Valley, CA, Baltimore, MD, and Golden, CO

    Science.gov (United States)

    Orozco, Daniel; Beyersdorf, A. J.; Ziemba, L. D.; Berkoff, T.; Zhang, Q.; Delgado, R.; Hennigan, C. J.; Thornhill, K. L.; Young, D. E.; Parworth, C.; Kim, H.; Hoff, R. M.

    2016-06-01

    Aerosol hygroscopicity was investigated using a novel dryer-humidifier system, coupled to a TSI-3563 nephelometer, to obtain the light scattering coefficient (σscat) as a function of relative humidity (RH) in hydration and dehydration modes. The measurements were performed in Porterville, CA (10 January to 6 February 2013), Baltimore, MD (3-30 July 2013), and Golden, CO (12 July to 10 August 2014). Observations in Porterville and Golden were part of the NASA-sponsored Deriving Information on Surface Conditions from Column and Vertically Resolved Observations Relevant to Air Quality project. The measured σscat under varying RH in the three sites was combined with ground aerosol extinction, PM2.5 mass concentrations, and particle composition measurements and compared with airborne observations performed during campaigns. The enhancement factor, f(RH), defined as the ratio of σscat(RH) at a certain RH divided by σscat at a dry value, was used to evaluate the aerosol hygroscopicity. Particles in Porterville showed low average f(RH = 80%) (1.42) which was attributed to the high carbonaceous loading in the region where residential biomass burning and traffic emissions contribute heavily to air pollution. In Baltimore, the high average f(RH = 80%) (2.06) was attributed to the large contribution of SO42- in the region. The lowest water uptake was observed in Golden, with an average f(RH = 80%) = 1.24 where organic carbon dominated the particle loading. Different empirical fits were evaluated using the f(RH) data. The widely used Kasten (gamma) model was found least satisfactory, as it overestimates f(RH) for RH < 75%. A better empirical fit with two power law curve fitting parameters c and k was found to replicate f(RH) accurately from the three sites. The relationship between the organic carbon mass and the species that are affected by RH and f(RH) was also studied and categorized.

  20. The University of Texas M.D. Anderson Cancer Center Proton Therapy Facility

    Science.gov (United States)

    Smith, Alfred; Newhauser, Wayne; Latinkic, Mitchell; Hay, Amy; McMaken, Bruce; Styles, John; Cox, James

    2003-08-01

    The University of Texas M.D. Anderson Cancer Center (MDACC), in partnership with Sanders Morris Harris Inc., a Texas-based investment banking firm, and The Styles Company, a developer and manager of hospitals and healthcare facilities, is building a proton therapy facility near the MDACC main complex at the Texas Medical Center in Houston, Texas USA. The MDACC Proton Therapy Center will be a freestanding, investor-owned radiation oncology center offering state-of-the-art proton beam therapy. The facility will have four treatment rooms: three rooms will have rotating, isocentric gantries and the fourth treatment room will have capabilities for both large and small field (e.g. ocular melanoma) treatments using horizontal beam lines. There will be an additional horizontal beam room dedicated to physics research and development, radiation biology research, and outside users who wish to conduct experiments using proton beams. The first two gantries will each be initially equipped with a passive scattering nozzle while the third gantry will have a magnetically swept pencil beam scanning nozzle. The latter will include enhancements to the treatment control system that will allow for the delivery of proton intensity modulation treatments. The proton accelerator will be a 250 MeV zero-gradient synchrotron with a slow extraction system. The facility is expected to open for patient treatments in the autumn of 2005. It is anticipated that 675 patients will be treated during the first full year of operation, while full capacity, reached in the fifth year of operation, will be approximately 3,400 patients per year. Treatments will be given up to 2-shifts per day and 6 days per week.

  1. QM/MD simulation of SWNT nucleation on transition-metal carbide nanoparticles.

    Science.gov (United States)

    Page, Alister J; Yamane, Honami; Ohta, Yasuhito; Irle, Stephan; Morokuma, Keiji

    2010-11-10

    The mechanism and kinetics of single-walled carbon nanotube (SWNT) nucleation from Fe- and Ni-carbide nanoparticle precursors have been investigated using quantum chemical molecular dynamics (QM/MD) methods. The dependence of the nucleation mechanism and its kinetics on environmental factors, including temperature and metal-carbide carbon concentration, has also been elucidated. It was observed that SWNT nucleation occurred via three distinct stages, viz. the precipitation of the carbon from the metal-carbide, the formation of a "surface/subsurface" carbide intermediate species, and finally the formation of a nascent sp(2)-hybidrized carbon structure supported by the metal catalyst. The SWNT cap nucleation mechanism itself was unaffected by carbon concentration and/or temperature. However, the kinetics of SWNT nucleation exhibited distinct dependences on these same factors. In particular, SWNT nucleation from Ni(x)C(y) nanoparticles proceeded more favorably compared to nucleation from Fe(x)C(y) nanoparticles. Although SWNT nucleation from Fe(x)C(y) and Ni(x)C(y) nanoparticle precursors occurred via an identical route, the ultimate outcomes of these processes also differed substantially. Explicitly, the Ni(x)-supported sp(2)-hybridized carbon structures tended to encapsulate the catalyst particle itself, whereas the Fe(x)-supported structures tended to form isolated SWNT cap structures on the catalyst surface. These differences in SWNT nucleation kinetics were attributed directly to the relative strengths of the metal-carbon interaction, which also dictates the precipitation of carbon from the nanoparticle bulk and the longevity of the resultant surface/subsurface carbide species. The stability of the surface/subsurface carbide was also influenced by the phase of the nanoparticle itself. The observations agree well with experimentally available data for SWNT growth on iron and nickel catalyst particles.

  2. Should MD-PhD programs encourage graduate training in disciplines beyond conventional biomedical or clinical sciences?

    Science.gov (United States)

    O'Mara, Ryan J; Hsu, Stephen I; Wilson, Daniel R

    2015-02-01

    The goal of MD-PhD training programs is to produce physician-scientists with unique capacities to lead the future biomedical research workforce. The current dearth of physician-scientists with expertise outside conventional biomedical or clinical sciences raises the question of whether MD-PhD training programs should allow or even encourage scholars to pursue doctoral studies in disciplines that are deemed nontraditional, yet are intrinsically germane to major influences on health. This question is especially relevant because the central value and ultimate goal of the academic medicine community is to help attain the highest level of health and health equity for all people. Advances in medical science and practice, along with improvements in health care access and delivery, are steps toward health equity, but alone they will not come close to eliminating health inequalities. Addressing the complex health issues in our communities and society as a whole requires a biomedical research workforce with knowledge, practice, and research skills well beyond conventional biomedical or clinical sciences. To make real progress in advancing health equity, educational pathways must prepare physician-scientists to treat both micro and macro determinants of health. The authors argue that MD-PhD programs should allow and encourage their scholars to cross boundaries into less traditional disciplines such as epidemiology, statistics, anthropology, sociology, ethics, public policy, management, economics, education, social work, informatics, communications, and marketing. To fulfill current and coming health care needs, nontraditional MD-PhD students should be welcomed and supported as valuable members of our biomedical research workforce. PMID:25354071

  3. Payer Perspectives on PCSK9 Inhibitors: A Conversation with Stephen Gorshow, MD, and James T. Kenney, RPh, MBA.

    Science.gov (United States)

    Mehr, Stanton R

    2016-02-01

    The new proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors can have significant budget effects, depending on the breadth of the US Food and Drug Administration (FDA)'s approved labeling. American Health & Drug Benefits asked Stephen Gorshow, MD, Regional Medical Director, UnitedHealthcare, and James T. Kenney, RPh, MBA, Manager, Specialty and Pharmacy Contracts, Harvard Pilgrim Health Care, to participate in a teleconference to better understand how payers are approaching the management of these agents. PMID:27066194

  4. Payer Perspectives on PCSK9 Inhibitors: A Conversation with Stephen Gorshow, MD, and James T. Kenney, RPh, MBA

    OpenAIRE

    Mehr, Stanton R.

    2016-01-01

    The new proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors can have significant budget effects, depending on the breadth of the US Food and Drug Administration (FDA)'s approved labeling. American Health & Drug Benefits asked Stephen Gorshow, MD, Regional Medical Director, UnitedHealthcare, and James T. Kenney, RPh, MBA, Manager, Specialty and Pharmacy Contracts, Harvard Pilgrim Health Care, to participate in a teleconference to better understand how payers are approaching the ma...

  5. Fission of 255,256Es, 255-257Fm, and 258Md at moderate excitation energies

    NARCIS (Netherlands)

    Britt, H.C.; Hoffman, D.C.; Plicht, J. van der; Wilhelmy, J.; Cheifetz, E.; Dupzyk, R.J.; Lougheed, R.W.

    1984-01-01

    The fission of 255,256Es, 255-257Fm, and 258Md has been studied in the excitation energy range from threshold to 25 MeV. A target of 254Es was used in the direct reaction studies; (d,pf), (t,pf), (3He,df), (3He,pf), and in the compound induced fission reactions formed with p, d, t, and α particle pr

  6. MD 755: Instability threshold and tune shift study with reduced retraction between primary and secondary collimators in IR7

    CERN Document Server

    Carver, Lee Robert; Mereghetti, Alessio; Bruce, Roderik; Metral, Elias; Salvant, Benoit; Nisbet, David; Redaelli, Stefano; Salvachua Ferrando, Belen Maria; CERN. Geneva. ATS Department

    2016-01-01

    The purpose of this MD is to quantify in terms of stabilising octupole current threshold the impedance change when reducing the retraction between the primary and secondary collimators in IR7. This will be performed by first measuring the octupole current threshold required for stability with the tighter secondary collimator settings at 6.5 (w.r.t. to the nominal settings at 8 ), and then measuring the tune shift that occurs when the collimators are moved to the new settings.

  7. Should MD-PhD programs encourage graduate training in disciplines beyond conventional biomedical or clinical sciences?

    Science.gov (United States)

    O'Mara, Ryan J; Hsu, Stephen I; Wilson, Daniel R

    2015-02-01

    The goal of MD-PhD training programs is to produce physician-scientists with unique capacities to lead the future biomedical research workforce. The current dearth of physician-scientists with expertise outside conventional biomedical or clinical sciences raises the question of whether MD-PhD training programs should allow or even encourage scholars to pursue doctoral studies in disciplines that are deemed nontraditional, yet are intrinsically germane to major influences on health. This question is especially relevant because the central value and ultimate goal of the academic medicine community is to help attain the highest level of health and health equity for all people. Advances in medical science and practice, along with improvements in health care access and delivery, are steps toward health equity, but alone they will not come close to eliminating health inequalities. Addressing the complex health issues in our communities and society as a whole requires a biomedical research workforce with knowledge, practice, and research skills well beyond conventional biomedical or clinical sciences. To make real progress in advancing health equity, educational pathways must prepare physician-scientists to treat both micro and macro determinants of health. The authors argue that MD-PhD programs should allow and encourage their scholars to cross boundaries into less traditional disciplines such as epidemiology, statistics, anthropology, sociology, ethics, public policy, management, economics, education, social work, informatics, communications, and marketing. To fulfill current and coming health care needs, nontraditional MD-PhD students should be welcomed and supported as valuable members of our biomedical research workforce.

  8. Payer Perspectives on PCSK9 Inhibitors: A Conversation with Stephen Gorshow, MD, and James T. Kenney, RPh, MBA.

    Science.gov (United States)

    Mehr, Stanton R

    2016-02-01

    The new proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors can have significant budget effects, depending on the breadth of the US Food and Drug Administration (FDA)'s approved labeling. American Health & Drug Benefits asked Stephen Gorshow, MD, Regional Medical Director, UnitedHealthcare, and James T. Kenney, RPh, MBA, Manager, Specialty and Pharmacy Contracts, Harvard Pilgrim Health Care, to participate in a teleconference to better understand how payers are approaching the management of these agents.

  9. Detection of the bovine viral diarrhoea / mucosal disease (BVD/MD) virus in tissues from aborted ruminant foetuses using immunohistochemistry

    OpenAIRE

    S. M. Njiro; C.M. Nkosi

    2009-01-01

    Various tissues from aborted ruminant foetuses were collected, fixed in formalin and embedded in paraffin wax. Sections were made and exposed to a primary monoclonal antibody against the bovine viral diarrhoea / mucosal disease (BVD/MD) virus, and subsequently to a goat anti-mouse secondary antibody conjugated to horse radish peroxidase (HRP). Diaminobenzidine (DAB) was the substrate and it released a brown pigment in the tissues on reacting with the HRP in an immunohistochemistry (IHC) proce...

  10. Medical expert systems developed in j.MD, a Java based expert system shell: application in clinical laboratories.

    Science.gov (United States)

    Van Hoof, Viviane; Wormek, Arno; Schleutermann, Sylvia; Schumacher, Theo; Lothaire, Olivier; Trendelenburg, Christian

    2004-01-01

    Growing complexity of diagnostic tests, combined with increased workload, stringent laboratory accreditation demands, continuous shortening of turn-around-time and budget restrictions have forced laboratories to automate most of their iterative tasks. Introduction of artificial intelligence by means of expert systems has gained an important place in this automation process. Different parts of clinical laboratory activity can benefit from their implementation and the present project deals with one aspect, namely the clinical interpretation of diagnostic tests. This paper describes how j.MD, a new Java based expert system shell, was used to reprogram the expert system for interpretation of amylase isoenzyme patterns that has been in use for many years in our laboratory, and that was originally programmed in Pro.MD, a Prolog based expert system shell. One of the most important advantages of the j.MD system is its bidirectional link with the laboratory information system. This project shows how expert systems for the interpretation of complex diagnostic tests that demand specific expertise can become an integrated part of the automated clinical chemistry lab.

  11. 基于MD5加密算法的系统安全登录研究

    Institute of Scientific and Technical Information of China (English)

    孙杨

    2013-01-01

      现在许多业务系统都是基于网络环境的,虽然满足了系统应用方便,共享性好的要求,但同时在系统安全上也带来了一些问题。如何消除安全隐患,增强登录模块的安全性,这是摆在系统建设者面前的一道课题。MD5即Me ssage-Digest Algorithm 5(信息-算法5),用于确保信息传输完整一致,是计算机广泛使用的杂凑算法之一(又译算法、哈希算法),主流编程语言普遍已有MD5实现。系统可以借助MD5算法来强化安全措施,避免权限外用户浏览信息,从而提高业务系统的保密性。

  12. Magnetic records of Core MD77-181 in the Bay of Bengal and their paleoenvironmental implications

    Institute of Scientific and Technical Information of China (English)

    LI Haiyan; ZHANG Shihong; FANG Nianqiao; WANG Hongqiang

    2006-01-01

    High-resolution environmental magnetic measurements were carried out on Core MD77-181 in the Bay of Bengal, including magnetic susceptibility, anhysteretic remanent magnetization, isothermal remanent magnetization of all samples, and temperature-dependence of magnetic susceptibilities and magnetic hysteresis parameters of representative samples. The results suggest that (1) the magnetic mineral assemblage of the upper 9.82 m sediments (corresponding to the last 160 ka) is dominated by pseudo-single domain magnetite, with more abundant coarse grains in glacial periods than in interglacial periods; (2) the uppermost 6.50 m of sediments (corresponding to the last 70 ka) shows significant temporal variations in grain sizes of magnetic minerals, possibly reflecting the teleconnection between variations of the Indian summer monsoon and rapid cold events of the North Atlantic (Heinrich events); (3) the sediments below 9.82 m are dominated by paramagnetic minerals (probably including pyrites), suggesting reductive diagenesis. The magnetic records of Core MD77-181 are comparable to those of Core MD77-180 in the Bay of Bengal, and ODP Hole 722B in the Arabian Sea. This study suggests that the paleoceanographic event at ~160 ka significantly changed the redox state of the northern Indian Ocean, from a reductive environment before the event to an oxic or suboxic environment after the event.

  13. Studi Pengamanan Login Pada Sistem Informasi Akademik Menggunakan Otentifikasi One Time Password Berbasisis SMS dengan Hash MD5

    Directory of Open Access Journals (Sweden)

    Kartika Imam Santoso

    2016-01-01

    Full Text Available Pengamanan login untuk mengakses Sistem Informasi Akademik berbasis WEB, berupa pengamanan menggunakan OTP(One Time Password yang di bangkitkan dengan Hash MD5 yang menghasilkan sebuah kode lewat SMS untuk otentikasi.Aplikasi OTP menggunakan masukan untuk hash MD5 dari tabel mahasiswa yang diambil adalah field NIM, No telp, danwaktu akses. Hasil dari fungsi hash tersebut menghasilkan 32 digit bilangan hexadesimal, kemudian mengganti denganangka bila ditemukan huruf di dalamnya. Selanjutnya diambil enam digit dari bilangan tersebut. Enam angka tersebut yangdikirimkan sebagai OTP dengan layanan aplikasi Gammu berupa SMS dan juga disimpan dalam tabel. OTP yang dikirimkankepada pengguna akan dicocokkan dengan yang tersimpan dalam tabel untuk mengecek validitasnya. Apabila cocok antaraOTP yang dikirimkan dengan yang tersimpan dalam tabel, maka pengguna baru bisa mengakses Sistem Informasi Akademik(SIAKAD. OTP yang dihasilkan adalah untuk otentifikasi pengamanan akun pengguna SIAKAD setelah Login denganmemasukkan username dan password. Waktu aktif untuk pengamanan login dengan OTP berbasis SMS selama tiga menit,pembatasan tersebut adalah untuk mempersempit waktu hacker untuk menyadap dan menyusup. Selain itu juga sesuai denganuji coba yang telah dilakukan dengan beberapa layanan operator selular di IndonesiaKata kunci : Sistem Informasi Akademik; Login, Hash MD5; One Time Password; SMS; Gammu

  14. Preferential solvation and dynamics of Li{sup +} in aqueous ammonia solution: An ONIOM-XS MD simulation study

    Energy Technology Data Exchange (ETDEWEB)

    Kabbalee, Pilailuk [School of Chemistry, Institute of Science, Suranaree University of Technology and NANOTEC-SUT Center of Excellence on Advanced Functional Nanomaterials, Nakhon Ratchasima 30000 (Thailand); Tongraar, Anan, E-mail: anan_tongraar@yahoo.com [School of Chemistry, Institute of Science, Suranaree University of Technology and NANOTEC-SUT Center of Excellence on Advanced Functional Nanomaterials, Nakhon Ratchasima 30000 (Thailand); Kerdcharoen, Teerakiat [Department of Physics and NANOTEC Center of Excellence, Faculty of Science, Mahidol University, Bangkok 10400 (Thailand)

    2015-01-13

    Highlights: • An ONIOM-XS MD simulation of Li{sup +} in aqueous ammonia solution been performed. • Li{sup +} forms a favorable Li{sup +}[(H{sub 2}O){sub 3}NH{sub 3}][(H{sub 2}O){sub 11}(NH{sub 3}){sub 3}] complex. • The first solvation shell of Li{sup +} is somewhat flexible. • The “structure-making” ability of Li{sup +} is not too strong. • The second solvation shell of Li{sup +} is less structured. - Abstract: A more sophisticated quantum mechanics/molecular mechanics (QM/MM) molecular dynamics (MD) technique based on the ONIOM-XS method, called the ONIOM-XS MD, has been applied for studying the characteristics of Li{sup +} in an aqueous ammonia solution. As compared to the conventional QM/MM MD study, which predicts a clear water preference with the arrangement of the Li{sup +}[(H{sub 2}O){sub 4}][(H{sub 2}O){sub 4}] type, the ONIOM-XS MD simulation clearly reveals that this ion can order both water and ammonia molecules to form the preferred Li{sup +}[(H{sub 2}O){sub 3}NH{sub 3}][(H{sub 2}O){sub 11}(NH{sub 3}){sub 3}] complex. Of particular interest, it is observed that the “structure-making” ability of Li{sup +} is not too strong and that the first solvation shell of Li{sup +} is somewhat flexible, in which other different 4-fold coordinated species, such as Li{sup +}(H{sub 2}O){sub 4} and Li{sup +}(H{sub 2}O){sub 2}(NH{sub 3}){sub 2}, can frequently be formed. In addition, it is found that the second solvation shell of Li{sup +} is less structured, implying a small influence of Li{sup +} in ordering the solvent molecules in this shell.

  15. The Deadliest Catch: Reeling In Big Phish With a Deep MD5 Net

    Directory of Open Access Journals (Sweden)

    Brad Wardman

    2010-09-01

    Full Text Available Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0in; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin;} Because phishing continues to grow in prevalence resulting from new exploits and attack vectors, the traditional response using takedowns and blacklists does not seem to impede phishers.  A handful of law enforcement projects — such as the FBI's Digital PhishNet or the Internet Crime and Complaint Center (ic3.gov — have shown an ability to collect phishing data, but these collections have not resulted in a significant decline in criminal phishing activity.In this paper, a new system is demonstrated for prioritizing investigative resources. One way of correlating two phishing websites is by proving they were created by the same kit.  These kits contain the content files needed to create the counterfeit website as well as the email addresses and aliases of the web site creators.  This research provides a new method for correlating phishing evidence through the collection of phishing kits and a Deep MD5 Matching clustering algorithm. The correlation provides law enforcement with a means of prioritizing the allocation of limited investigative resources by identifying frequently repeating offenders.

  16. 电话中可以做的抛硬币游戏--MD5函数的说明及应用

    Institute of Scientific and Technical Information of China (English)

    史可富

    2005-01-01

    @@ 2004年我国密码学家、山东大学王小云教授成功破译被广泛应用于密码学的MD5之后,在世界范围内引起了很大轰动,MD5是一个什么样的函数?它在密码学中有什么作用?本文将对MD5给出一个简单的说明,并给出一个在现实生活中有趣应用来说明MD5的应用.

  17. Retroviral sequence located in border region of short unique region and short terminal repeat of Md5 strain of Marek's disease virus type 1.

    Science.gov (United States)

    Endoh, D; Ito, M; Cho, K O; Kon, Y; Morimura, T; Hayashi, M; Kuwabara, M

    1998-02-01

    A 246-base pair (bp) retroviral sequence, which was homologous to a long terminal repeat of avian erythroblastosis virus (AEV), was detected and cloned from Md5 strain (Md5) of Marek's disease virus type 1 (MDV1) by representational difference analysis (RDA). The retroviral sequence was thought to be located in the border region of short unique region (U(s) and short terminal repeat (TRs), but did not exist in the border region of U(s) and the inverted short repeat (IRs) of the Md5 genome. A cloned fragment of the US/TRs border region of the Md5 genome showed a construction of U-E'-R-U'-E-TRs with the regions designated as follows: E, expanded TRs reported by Jones et al. [Proc. Natl. Acad. Sci. U.S.A. 90, 3855, 1993]; E', a partial copy of the expanded TRs; R, the retroviral sequence detected in Md5 genome; U, TRs-end sequence of U(s); U', a partial copy of TRs-end sequence of U(s). The sequence unit indicated as E'-R-U' was thought to be heterogeneously repeated in the Md5 genome. Since this retroviral sequence reportedly did not exist in the original stock of Md5, the retroviral sequence is thought to be inserted in the Md5 genome without experimental co-infection of avian cells with retrovirus and MDV1. These results suggest that RDA could be useful for the detection of retroviral sequences in the herpesvirus genome.

  18. Muscular Dystrophy Surveillance Tracking and Research Network (MD STARnet): Case Definition in Surveillance for Childhood-Onset Duchenne/Becker Muscular Dystrophy

    OpenAIRE

    Mathews, Katherine D.; Cunniff, Chris; Kantamneni, Jiji R.; Ciafaloni, Emma; Miller, Timothy; Matthews, Dennis; Cwik, Valerie; Druschel, Charlotte; Miller, Lisa; Meaney, F. John; Sladky, John; Romitti, Paul A.

    2010-01-01

    The Muscular Dystrophy Surveillance Tracking and Research Network (MD STARnet) is a multisite collaboration to determine the prevalence of childhood-onset Duchenne/Becker muscular dystrophy and to characterize health care and health outcomes in this population. MD STARnet uses medical record abstraction to identify patients with Duchenne/Becker muscular dystrophy born January 1, 1982 or later who resided in one of the participating sites. Critical diagnostic elements of each abstracted record...

  19. MD5算法在高校媒体资产管理系统中的应用研究%Study of MD5 Algorithm in the System of Colleges and Universities'Media Asset Management

    Institute of Scientific and Technical Information of China (English)

    贾鹏程; 宋燕燕; 李绍彬; 王莉莉

    2009-01-01

    主要研究利用MD5算法的加密及文件校验功能,实现高校媒资系统中系统安全性管理、文件重复性校验、文件审查、明确责任等方面的应用,以达到优化高校媒体资产管理系统,提高其安全性及可用性.

  20. 一种基于MD5值的数字图像加密新算法%A NEW ENCRYPTION ALGORITHM FOR DIGITAL IMAGES BASED ON MD5 VALUE

    Institute of Scientific and Technical Information of China (English)

    葛锦环; 李际军

    2010-01-01

    数字图像在远距离传输时必须保证其完整性和安全性.采用数字图像本身的MD5值作为位加密周期序列,设计了一种简单、高效而且实用的图像加密算法.该算法针对数字图像的应用特点,既实现了图像完整性的验证功能又解决了图像安全性的问题.

  1. SOFTWARE IMPLEMENTATION OF DYNAMIC PASSWORD TECHNOLOGY BASED ON MD5 ALGORITHM%基于MD5算法的动态口令技术的软件实现

    Institute of Scientific and Technical Information of China (English)

    叶晰; 叶依如

    2009-01-01

    描述动态口令技术的基本原理,研究一种基于MD5加密算法的动态口令技术的软件实现方法,并通过实例演示了该方法的实际效果.对于开发各类电子商务网站的动态口令技术可以提供一定的帮助.

  2. Immunological Changes of Chicks Immunized with Marek‘s Disease Vaccines and Challenged with Virulent MD Virus

    Institute of Scientific and Technical Information of China (English)

    LiuZhonggui; GaoRong; 等

    1995-01-01

    The experiment was conducted to inoculate one-day old chicks with Marek's disecae(MD) trivalent and herpesvirus of turkey(HVT) vaccines separately,and then to challenge them with virulent MD virus(vMDV) at the age of 15 days,and 5,25,45,and 75 days after the challenge with vMDV,comparing with the cotrol-challenged chicks without immunization,to detect the immunoprotetive efficacy and dynamic changes of the inductive activity of interleukin-2(IL-2),expression of IL-2 receptor and proliferative function of T cells in thymus and spleen;the number of ANAET,APT,cells and IgG,IgM,IgA antibody-producing cells in Bursa Fabricius,spleen,thymus,cecal tonsil and Harder gland;as the amount of T cells and IgG,IgA in peripheral blood as well as the content of IgG,IgM and IgA in the tear,trachea washings,bile and intestinal fluids of the experimental chicks.The experimental results firstly demonstrate that the immunoregulation of IL-2,and IL-2 receptor,the cellualr and humoral immune resposes were significantly enhanced in the central and peripheral immune organs;the local mucosal immune funcsignificantly enhanced in the central and peripheral immune organs;the local mucosal immune function were markedly amplified in the respiratory and digestive tracts of the immunized-challenged,chicks,which were closely correlated with the immunoprotection against MD;the immune response and immunoprotective effect of the trivalent vaccine-immunized chicks wrer much better than those of HVT vaccine-immunized chicks.

  3. 基于MD5和DES算法的RFID标签签发和验证机制

    Institute of Scientific and Technical Information of China (English)

    胡冶; 李翔

    2015-01-01

    RFID标签的签发和验证是RFID应用系统的关键环节和重要节点,是RFID应用系统安全的基础和保障。通过引入MD5签名算法和DES加密算法,有效提高了RFID标签的防伪、防篡改、防复制的能力,增强了RFID标签的安全性。

  4. Investigation of laser shock induced ductile damage at ultra-high strain rate by using large scale MD simulations

    Science.gov (United States)

    Cuq-Lelandais, Jean-Paul; Boustie, Michel; Soulard, Laurent; Berthe, Laurent; Bontaz-Carion, Joelle; de Resseguier, Thibaut

    2012-03-01

    Laser driven shocks allow an investigation of materials behavior at very high strain rate (107s-1) and present a great interest for research applications. Microscopic simulations of ultra-short laser driven shock on micrometric Tantalum single-crystals have been performed by using the CEADAM Classical Molecular Dynamics code. This method, complementary to continuum models, provides an analysis the microscopic processes related to damage (ductile pore nucleation and growth) which occurs during spallation. These results are compared to spallation experimental data (VISAR signals, micro-tomography) obtained with the LULI100TW femtosecond laser in order to validate the MD behavior. Moreover, in the framework of a multi-scale approach, we show the possibility to use MD simulation to fit macroscopic damage models. This method is illustrated with an application to the parameters determination of Kanel damage model parameters. This also shows the high strain rates involved during damage process, around 109s-1, can approach the inter-atomic theoretical cohesion stress threshold.

  5. Multiscale MD Simulations of Folding Dynamics and Mobility of Beta-Amyloid Peptide on Lipid Bilayer Surfaces

    Science.gov (United States)

    van Tilburg, Scott; Cheng, Kelvin

    2013-03-01

    Early interaction events of beta-amyloid peptides with the neuronal membranes play a key role in the pathogenesis of Alzheimer's disease. We have used multiscale Molecular Dynamics (MD) simulations to study the protein folding dynamics and lateral mobility of beta-amyloid protein on the cholesterol-enriched and -depleted lipid nano-domains. Several independent simulation replicates of all-atom and coarse-grained MD simulations of beta-amyloid on different lipid bilayer nano-domains have been generated. Using Define Secondary Structure of Proteins (DSSP) algorithm and mean-square-distance (MSD) analysis, the protein conformation and the lateral diffusion coefficients of protein, as well as the lipid and water, were calculated as a function of simulation time up to 200 nanoseconds for atomistic and 2 microseconds for coarse-grained simulations per replicate in different bilayer systems. Subtle differences in the conformation and mobility of the protein were observed in lipid bilayers with and without cholesterol. The structural dynamics information obtained from this work will provide useful insights into understanding the role of protein/lipid interactions in the membrane-associated aggregation of protein on neuronal membranes. HHMI-Trinity University and NIH RC1-GM090897-02

  6. A combination of docking, QM/MM methods, and MD simulation for binding affinity estimation of metalloprotein ligands.

    Science.gov (United States)

    Khandelwal, Akash; Lukacova, Viera; Comez, Dogan; Kroll, Daniel M; Raha, Soumyendu; Balaz, Stefan

    2005-08-25

    To alleviate the problems in the receptor-based design of metalloprotein ligands due to inadequacies in the force-field description of coordination bonds, a four-tier approach was devised. Representative ligand-metalloprotein interaction energies are obtained by subsequent application of (1) docking with metal-binding-guided selection of modes, (2) optimization of the ligand-metalloprotein complex geometry by combined quantum mechanics and molecular mechanics (QM/MM) methods, (3) conformational sampling of the complex with constrained metal bonds by force-field-based molecular dynamics (MD), and (4) a single point QM/MM energy calculation for the time-averaged structures. The QM/MM interaction energies are, in a linear combination with the desolvation-characterizing changes in the solvent-accessible surface areas, correlated with experimental data. The approach was applied to structural correlation of published binding free energies of a diverse set of 28 hydroxamate inhibitors to zinc-dependent matrix metalloproteinase 9 (MMP-9). Inclusion of steps 3 and 4 significantly improved both correlation and prediction. The two descriptors explained 90% of variance in inhibition constants of all 28 inhibitors, ranging from 0.08 to 349 nM, with the average unassigned error of 0.318 log units. The structural and energetic information obtained from the time-averaged MD simulation results helped understand the differences in binding modes of related compounds.

  7. "Structure-making" ability of Na+ in dilute aqueous solution: an ONIOM-XS MD simulation study.

    Science.gov (United States)

    Sripa, Pattrawan; Tongraar, Anan; Kerdcharoen, Teerakiat

    2013-02-28

    An ONIOM-XS MD simulation has been performed to characterize the "structure-making" ability of Na(+) in dilute aqueous solution. The region of most interest, i.e., a sphere that includes Na(+) and its surrounding water molecules, was treated at the HF level of accuracy using LANL2DZ and DZP basis sets for the ion and waters, respectively, whereas the rest of the system was described by classical pair potentials. Detailed analyzes of the ONIOM-XS MD trajectories clearly show that Na(+) is able to order the structure of waters in its surroundings, forming two prevalent Na(+)(H(2)O)(5) and Na(+)(H(2)O)(6) species. Interestingly, it is observed that these 5-fold and 6-fold coordinated complexes can convert back and forth with some degrees of flexibility, leading to frequent rearrangements of the Na(+) hydrates as well as numerous attempts of inner-shell water molecules to interchange with waters in the outer region. Such a phenomenon clearly demonstrates the weak "structure-making" ability of Na(+) in aqueous solution.

  8. Microscopic dynamical description of proton-induced fission with the Constrained Molecular Dynamics (CoMD) Model

    CERN Document Server

    Vonta, N; Veselsky, M; Bonasera, A

    2015-01-01

    The microscopic description of nuclear fission still remains a topic of intense basic research. Un- derstanding nuclear fission, apart from a theoretical point of view, is of practical importance for energy production and the transmutation of nuclear waste. In nuclear astrophysics, fission sets the upper limit to the nucleosynthesis of heavy elements via the r-process. In this work we initiated a systematic study of intermediate energy proton-induced fission using the Constrained Molecu- lar Dynamics (CoMD) code. The CoMD code implements an effective interaction with a nuclear matter compressibility of K=200 (soft EOS) with several forms of the density dependence of the nucleon-nucleon symmetry potential. Moreover, a constraint is imposed in the phase-space occu- pation for each nucleon restoring the Pauli principle at each time step of the collision. A proper choice of the surface parameter of the effective interaction has been made to describe fission. In this work, we present results of fission calculation...

  9. Roles of Ⅴ/Ⅲ ratio and mixture degree in GaN growth: CFD and MD simulation study

    Institute of Scientific and Technical Information of China (English)

    Zhou An; Xiu Xiang-Qian; Zhang Rong; Xie Zi-Li; Hua Xue-Mei; Liu Bin; Han Ping

    2013-01-01

    To understand the mechanism of Gallium nitride (GaN) film growth is of great importance for their potential applications.In this paper,we investigate the growth behavior of the GaN film by combining computational fluid dynamics (CFD) and molecular dynamics (MD) simulations.Both of the simulations show that Ⅴ/Ⅲ mixture degree can have important impacts on the deposition behavior,and it is found that the more uniform the mixture is,the better the growth is.Besides,by using MD simulations,we illustrate the whole process of the GaN growth.Furthermore,we also find that the Ⅴ/Ⅲ ratio can affect the final roughness of the GaN film.When the Ⅴ/Ⅲ ratio is high,the surface of final GaN film is smooth.The present study provides insights into GaN growth from the macroscopic and microscopic views,which may provide some suggestions on better experimental GaN preparation.

  10. R2E-related MD: slow controlled losses for RadMon/BLM cross-checks

    CERN Document Server

    Calviani, M; Spiezia, G; Sapinski, M; Priebe, A; Nordt, A; Pojer, M; CERN. Geneva. ATS Department

    2011-01-01

    The purpose of the dedicated R2E MD has been to evaluate the R factor (i.e. the ratio between the thermal neutron fluence and the high energy hadron fluence (>20MeV) for various tunnel locations, to measure the HEH radiation level gradient along the MBC dipole and on the MQ, to check the ratio the BLM measured dose and RadMon SEU counts and to study the dose gradient between the standard BLM beam axis location and at the level of the equipment location. Within the R2E Mitigation Project, these accurate measurement and cross-check of the mentioned parameters are of great importance for the evaluation and interpretation of the R2E-related radiation levels, as well as for the evaluation of the failure cross-section of specific equipment (i.e. QPS ISO150). In addition, a short part of the MD has been devoted to the comparison of BLM signals generated by loss directed inwards and outwards with respect to the LHC ring.

  11. A comparative evaluation of the protective efficacy of rMd5deltaMeq and CVI988/ Rispens against a vv+ strain of Marek's disease virus infection in a series of recombinant congenic strains of White Leghorn chickens.

    Science.gov (United States)

    Chang, Shuang; Ding, Zhuang; Dunn, John R; Lee, Lucy F; Heidari, Mohammad; Song, Jiuzhou; Ernst, Catherine W; Zhang, Huanmin

    2011-09-01

    Marek's disease (MD) is a lymphoproliferative disease of domestic chickens caused by a highly infectious, oncogenic alpha-herpesvirus known as Marek's disease virus (MDV). MD is presently controlled by vaccination. Current MD vaccines include attenuated serotype 1 strains (e.g., CVI988/Rispens), avirulent serotype 2 (SB-1), and serotype 3 (HVT) MDV strains. In addition, recombinant MDV strains have been developed as potential new and more efficient vaccines to sustain the success of MD control in poultry. One of the candidate recombinant MDV strains, named rMd5deltaMeq, was derived from Md5, a very virulent strain of MDV lacking the MDV oncogene Meq. Our earlier reports suggest that rMd5deltaMeq provided protection equally well or better than commonly used MD vaccines in experimental and commercial lines of chickens challenged with very virulent plus (vv+) strains of MDV. In this study, maternal antibody-positive (trial 1) and negative (trial 2) chickens from a series of relatively MD resistant lines were either vaccinated with the rMd5deltaMeq or CVI988/Rispens followed by infection of a vv+ strain of MDV, 648A, passage 10. This report presents experimental evidence that the rMd5deltaMeq protected significantly better than the CVI988/Rispens (P < 0.01) in the relatively resistant experimental lines of chickens challenged with the vv+ strain of MDV. Together with early reports, the rMd5deltaMeq appeared to provide better protection, comparing with the most efficacious commercially available vaccine, CVI988/Rispens, for control of MD in lines of chickens regardless of their genetic background.

  12. Flavonoids from Radix Tetrastigmae inhibit TLR4/MD-2 mediated JNK and NF-κB pathway with anti-inflammatory properties.

    Science.gov (United States)

    Liu, Dandan; Cao, Gang; Han, Likai; Ye, Yilu; SiMa, Yuhan; Ge, Weihong

    2016-08-01

    Radix Tetrastigmae (RT) has immunomodulatory activity, particularly on inflammation and the flavonoids from RT (RTFs) are one of the main components. In this study, we detected the anti-inflammation potential of RTFs in LPS-induced RAW264.7 cells and tried to uncover the underlying mechanism. Results demonstrated that RTFs (10-160μg/ml) treatment significantly decreased LPS-induced production of pro-inflammatory mediators, including NO, IL-1β, TNF-α, IL-6, IL-12p40, sTNF-R1 and increased anti-inflammatory cytokine IL-10 expression in macrophages in a dose-dependent manner. Molecular research showed the up-regulated expression of TLR4, MD-2, MyD88 and TLR4/MD-2 complex induced by LPS were attenuated after RTFs treatment. Furthermore, phosphorylation and activity of JNK and NF-κB, two important downstream signaling molecules of TLR4/MD-2 pathway, were also changed along with TLR4/MD-2 complex. But no significant phosphorylation was observed on p38 and ERK. In conclusion, RTFs contribute to the regulation of LPS-induced inflammatory response in RAW264.7 cells through TLR4/MD-2 mediated NF-κB and JNK pathway. It may be a potential choice for the treatment of inflammation diseases. PMID:27235587

  13. Exploring Beta-Amyloid Protein Transmembrane Insertion Behavior and Residue-Specific Lipid Interactions in Lipid Bilayers Using Multiscale MD Simulations

    Science.gov (United States)

    Qiu, Liming; Vaughn, Mark; Cheng, Kelvin

    2013-03-01

    Beta-amyloid (Abeta) interactions with neurons are linked to Alzheimer's. Using a multiscale MD simulation strategy that combines the high efficiency of phase space sampling of coarse-grained MD (CGD) and the high spatial resolution of Atomistic MD (AMD) simulations, we studied the Abeta insertion dynamics in cholesterol-enriched and -depleted lipid bilayers that mimic the neuronal membranes domains. Forward (AMD-CGD) and reverse (CGD-AMD) mappings were used. At the atomistic level, cholesterol promoted insertion of Abeta with high (folded) or low (unfolded) helical contents of the lipid insertion domain (Lys28-Ala42), and the insertions were stabilized by the Lys28 snorkeling and Ala42-anchoring to the polar lipid groups of the bilayer up to 200ns. After the forward mapping, the folded inserted state switched to a new extended inserted state with the Lys28 descended to the middle of the bilayer while the unfolded inserted state migrated to the membrane surface up to 4000ns. The two new states remained stable for 200ns at the atomistic scale after the reverse mapping. Our results suggested that different Abeta membrane-orientation states separated by free energy barriers can be explored by the multiscale MD more effectively than by Atomistic MD simulations alone. NIH RC1-GM090897-02

  14. 基于MD5算法的动态双因子安全认证技术在企业ERP系统中的应用%Dynamic state based on MD5 algorithm in enterprise ERP system

    Institute of Scientific and Technical Information of China (English)

    岳建斌

    2010-01-01

    针对现有企业ERP系统采用用户单一静态口令安全机制所存在的安全漏洞问题,提出了一个基于MD5算法以及短信息动态口令+用户静态口令的双因子安全认证方法,并讨论了实现.该方法无须改变现有系统架构,可有效验证用户身份的合法性.弥补了传统单因子认证方法的很多弊端.

  15. Design and Research of Web Pages Detection Algorithms Based on MD5%基于MD5的网页去重算法的设计与研究

    Institute of Scientific and Technical Information of China (English)

    闫俊伢

    2013-01-01

    随着互联网的发展及网络信息的指数状增长,网络上出现了大量的重复网页,降低了检索的查全率和查准率,影响了检索效率.因此,网页去重的准确度直接影响着搜索引擎的质量.本文通过对结构化文本的描述,提出了一种基于MD5的改进的网页去重算法,并从算法内容、算法特征、算法设计进行了阐述,实验表明该方法对提高查全率和查准率具有很好的效果.

  16. Analysis and Realization of Data Coverage Scheme based on md5 Algorithm%基于md5算法的数据覆盖方法分析与实现

    Institute of Scientific and Technical Information of China (English)

    张孟资; 谢宝陵

    2011-01-01

    分析比较了数据覆盖技术在敏感数据保护方面的应用,阐述了数据覆盖技术的发展现状.结合现代磁盘编码技术的发展,提出了用md5算法来产生覆盖序列的一种数据覆盖方案.针对Windows FAT32文件结构介绍了一个数据覆盖系统设计的主要技术,并实现了数据恢复与擦除系统,验证了该数据覆盖方案的可行性.

  17. Research on Numerical Simulation of Ship-ice Collision Based on MD Nastran%基于MD Nastran的船-冰碰撞数值仿真研究

    Institute of Scientific and Technical Information of China (English)

    张爱锋; 宋艳平; 苏琳芳

    2015-01-01

    船舶与海冰的碰撞过程十分复杂,涉及多种非线性问题。文章运用 MD Nastran对船舶艏部与冰的碰撞进行数值仿真计算,来模拟这一过程。得到了碰撞结束后,船首和海冰的损伤变形情况,船体结构的应力应变情况,以及在船—冰相互作用过程中的能量变化,应力应变变化。研究结果描述了船舶与冰碰撞的详细过程,揭示了冰载荷作用下船体结构的响应规律,可为船舶抗冰载荷设计提供参考。%With the opening of the arctic passages, the navigation safety of ships in the region has be-come a significant concern. The interaction of ship-ice is a complex process, which involves a variety of nonlinear problems. This paper describes a numerical analysis to simulate the process between bow and ice collision using MD Nastran and provides the results such as deformation of bow and sea ice, stress and strain of hull structure and components of energy during ship-ice collisions. The research results from the simulations show the detailed process of ship-ice collision, indicate the response of hull structure and provide a significant reference for the design of ship structure under ice loads.

  18. Suppression of Amplitude dependent closest tune approach and first tests of the ADT as an AC-dipole (MD 1412)

    CERN Document Server

    Persson, Tobias Hakan Bjorn; Maclean, Ewen Hamish; Olexa, Jakub; Tomas Garcia, Rogelio; Valuch, Daniel; Wierichs, David Alexander; Carlier, Felix Simon; CERN. Geneva. ATS Department

    2016-01-01

    The amplitude detuning has been observed to decrease significantly as the horizontal and vertical tunes are approaching each other. The measured tune split (Qₓ −Qᵧ) versus amplitude was several times bigger than what can be explained with linear coupling during the non-linear MD in 2012 [1]. This effect is potentially harmful since it might cause a loss of Landau damping, hence giving rise to instabilities. In this MD we validated the findings in the MD from 2012 and demonstrated the possibility to mitigate this effect through having opposite polarity of the focusing and defocusing octupoles (MOD and MOF). The amplitude dependent dependent closest tune approach was also measured with the AC-dipole and gave unexpected results. A first test of using the ADT as an AC-dipole was also performed.

  19. Research And Implement of Message-Digest Algorithm 5%MD5报文摘要算法的研究与实现

    Institute of Scientific and Technical Information of China (English)

    袁薇

    2009-01-01

    在信息加密中,采用报文摘要的方法不但可以节省加密时问,还可以节省报文传输和存储的开销.在目前提出多种报文摘要中,应用最广的就是MD5.本文针对MD5报文摘要算法进行了深入研究,分析了算法的安全性,通过程序开发对算法进行了实现,总结了MD5加密算法的应用.

  20. Bordetella pertussis Lipid A Recognition by Toll-like Receptor 4 and MD-2 Is Dependent on Distinct Charged and Uncharged Interfaces.

    Science.gov (United States)

    Maeshima, Nina; Evans-Atkinson, Tara; Hajjar, Adeline M; Fernandez, Rachel C

    2015-05-22

    Lipid A in LPS activates innate immunity through the Toll-like receptor 4 (TLR4)-MD-2 complex on host cells. Variation in lipid A has significant consequences for TLR4 activation and thus may be a means by which Gram-negative bacteria modulate host immunity. However, although even minor changes in lipid A structure have been shown to affect downstream immune responses, the mechanism by which the TLR4-MD-2 receptor complex recognizes these changes is not well understood. We previously showed that strain BP338 of the human pathogen Bordetella pertussis, the causative agent of whooping cough, modifies its lipid A by the addition of glucosamine moieties that promote TLR4 activation in human, but not mouse, macrophages. Using site-directed mutagenesis and an NFκB reporter assay screen, we have identified several charged amino acid residues in TLR4 and MD-2 that are important for these species-specific responses; some of these are novel for responses to penta-acyl B. pertussis LPS, and their mutation does not affect the response to hexa-acylated Escherichia coli LPS or tetra-acylated lipid IVA. We additionally show evidence that suggests that recognition of penta-acylated B. pertussis lipid A is dependent on uncharged amino acids in TLR4 and MD-2 and that this is true for both human and mouse TLR4-MD-2 receptors. Taken together, we have demonstrated that the TLR4-MD-2 receptor complex recognizes variation in lipid A molecules using multiple sites for receptor-ligand interaction and propose that host-specific immunity to a particular Gram-negative bacterium is, at least in part, mediated by very subtle tuning of one of the earliest interactions at the host-pathogen interface.

  1. Effects of Fatty Acids on Low-Sulfur Diesel Lubricity:Experimental Investigation, DFT Calculation and MD Simulation

    Institute of Scientific and Technical Information of China (English)

    Luo Hui; Fan Weiyu; Li Yang; Zhao Pinhui; Nan Guozhi

    2013-01-01

    The continuous reduction in sulfur content of fuels would lead to diesel fuel with poor lubricity which could re-sult in engine pump failure. In the present work, fatty acids were adopted as lubricity additives to low-sulfur diesel fuel. It was attempted to correlate the molecular structures of fatty acids, such as carbon chain length, degree of saturation and hy-droxylation, to their lubricity enhancement, which was evaluated by the High-Frequency Reciprocating Rig (HFRR) meth-od. The efifciency order was supported by the density functional theory (DFT) calculations and the molecular dynamics (MD) simulations. The lubricity enhancing properties of fatty acids are mainly determined by the cohesive energy of adsorbed iflms formed on iron surface. The greater the cohesive energy, the more efifciently the fatty acid would enhance the lubricity of low-sulfur diesel fuel.

  2. Lignée de Canola MON88302 TruFlexMC Roundup ReadyMD

    OpenAIRE

    Canada, Publié par la Direction des aliments de Santé

    2014-01-01

    Santé Canada a avisé Monsanto Canada Inc. qu’il ne s’oppose pas à la vente d’aliments dérivés du canola MON88302 (canola TruFlexMC Roundup ReadyMD). Le Ministère a réalisé une évaluation approfondie de cette lignée de canola conformément à ses Lignes directrices sur l’évaluation de l’innocuité des aliments nouveaux. Ces lignes directrices sont fondées sur des principes admis internationalement pour l’établissement de l’innocuité des aliments à caractères nouveaux. L...

  3. Book review of "The Ethics of Coercion in Mass Casualty Medicine" by Griffin Trotter MD, PhD

    Directory of Open Access Journals (Sweden)

    Singh Sonal

    2007-10-01

    Full Text Available Abstract Public health ethics is neither taught widely in medical schools or schools of public health in the US or around the world. It is not surprising that health care professionals are particularly challenged when faced with ethical questions which extend beyond safeguarding the interests of their individual patients to matters that affect overall public good. The perceived threat of terror after September 11 2007, the anthrax attacks and the Katrina debacle are recent circumstances which may result in coercion. These have piqued the interest of medical professionals and the general public on public health ethics. The Ethics of Coercion in Mass Casualty Medicine written by Griffin Trotter MD, PhD attempts to fill a timely void in this area by examining the ethics of coercion in times of public health disasters.

  4. A Modification of Gamma Surveymeter Dosemeter 3007A for Monitoring Use Ethernet by PLC T100MD Series

    International Nuclear Information System (INIS)

    It has been modified a gamma surveymeter Dosemeter 3007A. The Surveymeter represents analogous surveymeter, so that an interface for data acquisition is required. Acquisition system from surveymeter is added to the voltage amplifier module from 0 - 200 mV to 0 - 5 V. This voltage value will represent of doses 0 - 5 mR/hour. Hereinafter the analogous signal 0 - 5 V as signal of input to peripheral of PLC T100MD series. Data in the form of processed analogous signal presented at local display of PLC. For long distance monitoring, data have been sent to a computer from PLC by ethernet. After this modification, the surveymeter can be used to monitor from long distance. By using Internet Service Provider, monitoring can be done at any time and any where as long as network internet is available. (author)

  5. Bacterial diversity in sediments of core MD05-2902 from the Xisha Trough, the South China Sea

    Institute of Scientific and Technical Information of China (English)

    LI Tao; WANG Peng

    2014-01-01

    A sediment core MD05-2902 was collected from the deep-sea basin of the Xisha Trough. The vertical dis-tribution and diversity of bacteria in the core was investigated through ten sub-sampling with an interval of 1 m using bacterial 16S rRNA gene as a phylogenetic bio-marker. Eighteen phylogenetic groups were identified from 16S rRNA gene clone libraries. The dominant bacterial groups were JS1, Planctomycetes and Chloroflexi, which accounted for 30.6%, 16.6%, and 15.6%of bacterial clones in the libraries, respectively. In order to reveal the relationship between biotic and abiotic data, a nonmetric multidimensional scaling analysis was performed. The result revealed that theδ15N,δ13C, total organic carbon and total organic ni-trogen possibly influenced the bacterial community structure. This study expanded our knowledge of the biogeochemical cycling in the Xisha Trough sediment.

  6. Monomerization alters the dynamics of the lid region in Campylobacter jejuni CstII: an MD simulation study.

    Science.gov (United States)

    Prabhakar, Pradeep Kumar; Srivastava, Alka; Rao, K Krishnamurthy; Balaji, Petety V

    2016-04-01

    CstII, a bifunctional (α2,3/8) sialyltransferase from Campylobacter jejuni, is a homotetramer. It has been reported that mutation of the interface residues Phe121 (F121D) or Tyr125 (Y125Q) leads to monomerization and partial loss of enzyme activity, without any change in the secondary or tertiary structures. MD simulations of both tetramer and monomer, with and without bound donor substrate, were performed for the two mutants and WT to understand the reasons for partial loss of activity due to monomerization since the active site is located within each monomer. RMSF values were found to correlate with the crystallographic B-factor values indicating that the simulations are able to capture the flexibility of the molecule effectively. There were no gross changes in either the secondary or tertiary structure of the proteins during MD simulations. However, interface is destabilized by the mutations, and more importantly the flexibility of the lid region (Gly152-Lys190) is affected. The lid region accesses three major conformations named as open, intermediate, and closed conformations. In both Y121Q and F121D mutants, the closed conformation is accessed predominantly. In this conformation, the catalytic base His188 is also displaced. Normal mode analysis also revealed differences in the lid movement in tetramer and monomer. This provides a possible explanation for the partial loss of enzyme activity in both interface mutants. The lid region controls the traffic of substrates and products in and out of the active site, and the dynamics of this region is regulated by tetramerization. Thus, this study provides valuable insights into the role of loop dynamics in enzyme activity of CstII. PMID:26208676

  7. A standard case of subtitling. : A comparative analysis of the subtitling of Scrubs and House M.D. with a focus on medical terminology.

    OpenAIRE

    Lindell, Klara

    2010-01-01

    Toury’s first law of translation states that translation of all kinds entails standardisation and, moreover, that the more peripheral the status of a text is, the more standardised its translation will be. As such, the purpose of this essay was to investigate to what extent this holds true in the Swedish translations of the two US television hospital shows Scrubs and House M.D. Though they are both hospital shows, House M.D. – considering its unprecedented genre hybridity and unusual plot str...

  8. The Information Content of Note Disclosures and MD&A Information in the Financial Report – A Study of Market Reactions in Denmark

    DEFF Research Database (Denmark)

    Thinggaard, Frank; Sønderby Jeppesen, Carsten; Madsen, Kasper

    2015-01-01

    The preparation of disclosures in the financial report constitutes a significant cost to most companies, but do the disclosures have information content to investors? This paper examines stock market reactions to the release of note disclosures and MD&A (management discussion and analysis......) information. The study is based on data from the Danish capital market in 2006-2009 because here it is largely possible to isolate the release of such information from other information in the financial report. The primary results suggest that for some companies, note disclosures and information in the MD...

  9. Synergy between Colistin and the Signal Peptidase Inhibitor MD3 Is Dependent on the Mechanism of Colistin Resistance in Acinetobacter baumannii.

    Science.gov (United States)

    Martínez-Guitián, Marta; Vázquez-Ucha, Juan C; Odingo, Joshua; Parish, Tanya; Poza, Margarita; Waite, Richard D; Bou, German; Wareham, David W; Beceiro, Alejandro

    2016-07-01

    Synergy between colistin and the signal peptidase inhibitor MD3 was tested against isogenic mutants and clinical pairs of Acinetobacter baumannii isolates. Checkerboard assays and growth curves showed synergy against both colistin-susceptible strains (fractional inhibitory concentration index [FICindex] = 0.13 to 0.24) and colistin-resistant strains with mutations in pmrB and phosphoethanolamine modification of lipid A (FICindex = 0.14 to 0.25) but not against colistin-resistant Δlpx strains with loss of lipopolysaccharide (FICindex = 0.75 to 1). A colistin/MD3 combination would need to be targeted to strains with specific colistin resistance mechanisms. PMID:27139471

  10. (Konstitutsiooniline) renvoi: kas põhiseaduslik nõue või kaera Trooja hobusele? / Berit Aaviksoo

    Index Scriptorium Estoniae

    Aaviksoo, Berit, 1978-

    2015-01-01

    Võrdsuspõhiõiguse ning pöörddiskrimineerimise kaotamise nõude mõjust Eesti õiguskorras. Artikkel põhineb 3. oktoobril 2014 Tartus 33. Eesti õigusteadlaste päevadel „Kümme aastat õiguslõimet“ peetud ettekandel

  11. Miks ohverdada veel üks põlvkond? / Christopher õBeazley ; interv. Berit Teeäär

    Index Scriptorium Estoniae

    õBeazley, Christopher

    2008-01-01

    Euroopa Parlamendi Balti-Euroopa tugirühma esimees Christopher Beazley vastab küsimustele, mis puudutavad tema huvi Balti riikide ja Läänemere regiooni vastu, Läänemere piirkonnas paiknevate Euroopa Liidu vanade ja uute liikmesriikide kontseptuaalsete erinevuste tõttu tekkida võivaid lahkhelisid, Euroopa Liidu ja Venemaa suhete seisu ja arenguperspektiive, liidu ühise välispoliitika kujunemise võimalikkust, Kaliningradi oblasti demilitariseerimist ning selle enklaavi muutmist Euroopa Liidu ja Venemaa vahelise vabakaubanduse pilootprojektiks, Läänemere ökoloogilise olukorra parandamist

  12. Identification of the gene MdSOD3 and its role in resisting heavy metal stress in housefly (Musca domestica)%家蝇MdSOD3基因的鉴定及其在抵抗重金属胁迫中的作用

    Institute of Scientific and Technical Information of China (English)

    唐婷; 高一夫; 刘艳娟; 葛旭东; 李响; 柳峰松

    2012-01-01

    超氧化物歧化酶(SOD)是一种重要的抗氧化酶,在昆虫抗氧化保护过程中起着重要作用.本研究通过RTPCR技术鉴定了家蝇Musca domestica MdSOD3基因(GenBank登录号为JQ408979),cDNA序列817 bp,开放阅读框534 bp,推导的多肽序列含有177个氨基酸.同源性分析及NJ法系统分析表明MdSOD3与其他物种的Cu/ZnSOD关系较近.荧光定量PCR检测该基因在家蝇幼虫脂肪体、肠、表皮和血细胞中不存在差异表达;在受到不同浓度重金属Cd2+刺激时,MdSOD3基因呈诱导性表达,5 mmol/L时表达量最高.通过RNAi策略技术成功敲低MdSOD3表达水平.将RNA干扰60h的幼虫置于5 mmol/L Cd2+处理24h后死亡率明显升高,并且出现中毒表象.NBT活性染色检测到体外重组表达的MdSOD3具有明显的酶活性.结果提示MdSOD3基因可能在家蝇抗逆防御过程中起着重要作用.%As a member of the antioxidant enzymes, superoxide dismutase ( SOD) plays a key role in insect antioxidant protection system. In this study, the full-length cDNA of a SOD gene MdSOD3 (GenBank accession no. JQ408979) from the housefly, Musca domestica, was cloned and characterized by RT-PCR, which is 817 bp in length, the open reading frame is 534 bp encoding 177 amino acid residues. The homologous alignment and phylogenetic tree indicate that the MdSODi from housefly belongs to Cu/ZnSOD family. The temporal expression profiling revealed that MdSODi was present in the fat body, gut, hemocytes and cuticle. The expression of MdSODi was enhanced by Cd stress. The highest expression level was found in treatment at 5 mmol/L Cd2+ within a 24 h period. Quantitative PCR (qPCR) showed that mRNA level of MdSODi gene was reduced compared to the control by RNAi. High mortality was observed in the larvae treated with dsRNA of MdSODi for 60 h at 5 mmol/L Cd stress for 24 h. The RNAi of MdSODi gene resulted in the larval abdominal apex to become black. The results suggest that MdSODi may play an

  13. MD300测深系统在河道地形测绘中的应用%Application of MD300 sounding system to the topographic mapping of river channels

    Institute of Scientific and Technical Information of China (English)

    肖华; 唐从胜; 田次平

    2001-01-01

    In recent years,the global positioning system(GPS) technique is rapidly developing,since it is characterized by continuity,real-time,all-weather operation with high accuracy,this technique has found extensive application in survey,positioning,navigation.MD300 sounding system is a new topograpbic survey system especially for water areas supported by GPS.In combination with the development and application of the sounding system carried out by the Jingjiang Investigation Bureau of Hydrology and Water Resources of Changjiang Water Resources Commission,the structural function and system configuration and the implementation methods of the system are presented.From the viewpoint of its practical effect of application,this sounding system has characteristics of accurate positioning,accurate water depth acquisition and high automation procedure,compared with conventional metheds.The system is an ideal river channel mapping system.%近年来,全球定位系统(GPS)技术迅猛发展,由于它具有连续、实时、高精度、全天候的特点,使其在诸如测量、定位、导航中得到广泛应用。MD300测深系统是在GPS支持下的一种全新的水域地形测量系统。结合长江委荆江水文水资源局对该系统的开发、应用,介绍了其结构功能、系统配置及实现方法,从实际运用效果看,与常规测量方法相比,该系统具有定位精确、水深采集准确、自动化程度高等特点,是理想的河道测绘系统。

  14. 75 FR 2831 - Airworthiness Directives; McDonnell Douglas Corporation Model DC-10-10, DC-10-10F, and MD-10-10F...

    Science.gov (United States)

    2010-01-19

    ... Corporation Model DC- 10-10, DC-10-10F, and MD-10-10F Airplanes AGENCY: Federal Aviation Administration (FAA..., Aerospace Engineer, Airframe Branch, ANM-120L, FAA, Los Angeles Aircraft Certification Office, 3960... United States Code specifies the FAA's authority to issue rules on aviation safety. Subtitle I,...

  15. Muscavirus (MdHV) disease dynamics in house fly populations – how is this virus transmitted and has it potential as a biological control agent?

    Science.gov (United States)

    The newly classified family Hytrosaviridae comprises several double-stranded DNA viruses that have been isolated from various dipteran species. These viruses cause characteristic salivary gland hypertrophy and suppress gonad development in their hosts. One member, Muscavirus or MdHV, exclusively in...

  16. Preliminary comparison of the Essie and PubMed search engines for answering clinical questions using MD on Tap, a PDA-based program for accessing biomedical literature.

    Science.gov (United States)

    Sutton, Victoria R; Hauser, Susan E

    2005-01-01

    MD on Tap, a PDA application that searches and retrieves biomedical literature, is specifically designed for use by mobile healthcare professionals. With the goal of improving the usability of the application, a preliminary comparison was made of two search engines (PubMed and Essie) to determine which provided most efficient path to the desired clinically-relevant information.

  17. Inhibition of LPS binding to MD-2 co-receptor for suppressing TLR4-mediated expression of inflammatory cytokine by 1-dehydro-10-gingerdione from dietary ginger

    Energy Technology Data Exchange (ETDEWEB)

    Park, Sun Hong; Kyeong, Min Sik; Hwang, Yuri [College of Pharmacy, Chungbuk National University, Cheongju 361-763 (Korea, Republic of); Ryu, Shi Yong [Korea Research Institute of Chemical Technology, Daejeon 305-600 (Korea, Republic of); Han, Sang-Bae [College of Pharmacy, Chungbuk National University, Cheongju 361-763 (Korea, Republic of); Kim, Youngsoo, E-mail: youngsoo@chungbuk.ac.kr [College of Pharmacy, Chungbuk National University, Cheongju 361-763 (Korea, Republic of)

    2012-03-23

    Highlights: Black-Right-Pointing-Pointer 1-Dehydro-10-gingerdione (1D10G) from ginger inhibits LPS binding to MD-2. Black-Right-Pointing-Pointer 1D10G suppresses MyD88- or TRIF-dependent signaling in LPS-activated macrophages. Black-Right-Pointing-Pointer 1D10G down-regulates the expression of NF-{kappa}B-, AP1- or IRF3-target genes. Black-Right-Pointing-Pointer MD-2 is a molecular target in the anti-inflammatory action of 1D10G. -- Abstract: Myeloid differentiation protein 2 (MD-2) is a co-receptor of toll-like receptor 4 (TLR4) for innate immunity. Here, we delineated a new mechanism of 1-dehydro-10-gingerdione (1D10G), one of pungent isolates from ginger (Zingiber officinale), in the suppression of lipopolysaccharide (LPS)-induced gene expression of inflammatory cytokines. 1D10G inhibited LPS binding to MD-2 with higher affinity than gingerol and shogaol from dietary ginger. Moreover, 1D10G down-regulated TLR4-mediated expression of nuclear factor-{kappa}B (NF-{kappa}B) or activating protein 1 (AP1)-target genes such as tumor necrosis factor {alpha} (TNF-{alpha}) and interleukin-1{beta}, as well as those of interferon (IFN) regulatory factor 3 (IRF3)-target IFN-{beta} gene and IFN-{gamma} inducible protein 10 (IP-10) in LPS-activated macrophages. Taken together, MD-2 is a molecular target in the anti-inflammatory action of 1D10G.

  18. Research on the multi-message modification techniques on MD5%MD5碰撞攻击的多重消息修改技术的研究

    Institute of Scientific and Technical Information of China (English)

    陈士伟; 金晨辉

    2009-01-01

    通过对王小云等提出的消息修改技术以及Yu Sasaki等提出改进的消息修改技术进行研究,指出他们提出的多重消息修改技术并不总能使一个链接变量同时满足多个充分条件,并给出了确保一个链接变量同时满足多个充分条件的方法.此外还指出了在Liang Jie和Lai Xuejia的新的充分条件集中Yu Sasaki等的改进的多重消息修改技术对其中2个条件不能再实施,并提出了对其中一个新的消息修改技术,给出了对另外3个充分条件的新的多重消息修改技术,并通过实验对上述结果进行了验证且产生了新的MD5碰撞对.

  19. The structure and IR signatures of the arginine-glutamate salt bridge. Insights from the classical MD simulations.

    Science.gov (United States)

    Vener, M V; Odinokov, A V; Wehmeyer, C; Sebastiani, D

    2015-06-01

    Salt bridges and ionic interactions play an important role in protein stability, protein-protein interactions, and protein folding. Here, we provide the classical MD simulations of the structure and IR signatures of the arginine (Arg)-glutamate (Glu) salt bridge. The Arg-Glu model is based on the infinite polyalanine antiparallel two-stranded β-sheet structure. The 1 μs NPT simulations show that it preferably exists as a salt bridge (a contact ion pair). Bidentate (the end-on and side-on structures) and monodentate (the backside structure) configurations are localized [Donald et al., Proteins 79, 898-915 (2011)]. These structures are stabilized by the short (+)N-H⋯O(-) bonds. Their relative stability depends on a force field used in the MD simulations. The side-on structure is the most stable in terms of the OPLS-AA force field. If AMBER ff99SB-ILDN is used, the backside structure is the most stable. Compared with experimental data, simulations using the OPLS all-atom (OPLS-AA) force field describe the stability of the salt bridge structures quite realistically. It decreases in the following order: side-on > end-on > backside. The most stable side-on structure lives several nanoseconds. The less stable backside structure exists a few tenth of a nanosecond. Several short-living species (solvent shared, completely separately solvated ionic groups ion pairs, etc.) are also localized. Their lifetime is a few tens of picoseconds or less. Conformational flexibility of amino acids forming the salt bridge is investigated. The spectral signature of the Arg-Glu salt bridge is the IR-intensive band around 2200 cm(-1). It is caused by the asymmetric stretching vibrations of the (+)N-H⋯O(-) fragment. Result of the present paper suggests that infrared spectroscopy in the 2000-2800 frequency region may be a rapid and quantitative method for the study of salt bridges in peptides and ionic interactions between proteins. This region is usually not considered in spectroscopic

  20. The structure and IR signatures of the arginine-glutamate salt bridge. Insights from the classical MD simulations

    Energy Technology Data Exchange (ETDEWEB)

    Vener, M. V., E-mail: mikhail.vener@gmail.com [Mendeleev University of Chemical Technology, Moscow (Russian Federation); Odinokov, A. V. [Photochemistry Center of the Russian Academy of Sciences, Moscow (Russian Federation); Wehmeyer, C. [Free University, Berlin (Germany); Sebastiani, D. [Martin-Luther-Universität Halle-Wittenberg, Halle (Germany)

    2015-06-07

    Salt bridges and ionic interactions play an important role in protein stability, protein-protein interactions, and protein folding. Here, we provide the classical MD simulations of the structure and IR signatures of the arginine (Arg)–glutamate (Glu) salt bridge. The Arg-Glu model is based on the infinite polyalanine antiparallel two-stranded β-sheet structure. The 1 μs NPT simulations show that it preferably exists as a salt bridge (a contact ion pair). Bidentate (the end-on and side-on structures) and monodentate (the backside structure) configurations are localized [Donald et al., Proteins 79, 898–915 (2011)]. These structures are stabilized by the short {sup +}N–H⋯O{sup −} bonds. Their relative stability depends on a force field used in the MD simulations. The side-on structure is the most stable in terms of the OPLS-AA force field. If AMBER ff99SB-ILDN is used, the backside structure is the most stable. Compared with experimental data, simulations using the OPLS all-atom (OPLS-AA) force field describe the stability of the salt bridge structures quite realistically. It decreases in the following order: side-on > end-on > backside. The most stable side-on structure lives several nanoseconds. The less stable backside structure exists a few tenth of a nanosecond. Several short-living species (solvent shared, completely separately solvated ionic groups ion pairs, etc.) are also localized. Their lifetime is a few tens of picoseconds or less. Conformational flexibility of amino acids forming the salt bridge is investigated. The spectral signature of the Arg-Glu salt bridge is the IR-intensive band around 2200 cm{sup −1}. It is caused by the asymmetric stretching vibrations of the {sup +}N–H⋯O{sup −} fragment. Result of the present paper suggests that infrared spectroscopy in the 2000–2800 frequency region may be a rapid and quantitative method for the study of salt bridges in peptides and ionic interactions between proteins. This region is

  1. Verðmat fyrirtækja: Aðferðir og framkvæmd

    OpenAIRE

    Helga Lind Sigurbergsdóttir 1988

    2012-01-01

    Ritgerðin fjallar um verðmat fyrirtækja, aðferðir og framkvæmd. Í byrjun er útskýrt hver sé tilgangurinn með verðmati og hvers vegna fyrirtæki hafa áhuga á að framkvæma það. Helstu verðmatsaðferðir fyrirtækja verða svo kynntar til sögunnar og hverjir eru helstu árhrifaþættirnir við gerð verðmats. Farið yfir hvernig verðmat á sér stað hjá fyrirtækjum sem ekki eru skráð á skipulagðan verðbréfamarkað. Megináhersla ritgerðarinnar er þó á verðmat fyrirtækja sem eru skráð á skipulagðan verðbréfamar...

  2. Chronological constraints on Cordilleran Ice Sheet glaciomarine sedimentation from core MD02-2496 off Vancouver Island (western Canada)

    Science.gov (United States)

    Cosma, T. N.; Hendy, I. L.; Chang, A. S.

    2008-05-01

    Chronology based on 46 radiocarbon dates has been generated for MD02-2496, western Vancouver Island, Canada. Subsequent correlation between glaciomarine sedimentary sequences within the core and the terrestrial stratigraphy of the Cordilleran Ice Sheet for the last 50 ka provide new insight into Cordilleran Ice Sheet processes. Glaciomarine sedimentation associated with the most recent advance (Fraser Glaciation) of the Cordilleran Ice Sheet began at 30.5 cal kyr BP (˜25 14C kyr BP). Extremely high sedimentation rates indicate the ice sheet became proximal to the site at ˜19.5 cal kyr BP (16 14C kyr BP). Deposition of ice rafted detritus (IRD) began at ˜17 cal kyr BP (14 14C kyr BP), and abruptly terminated at ˜16.2 cal kyr BP (13.5 14C kyr BP) indicating rapid regional ice sheet retreat. A minor IRD event followed at ˜14.7 cal kyr BP (12.5 14C kyr BP). Glaciomarine sediment deposition abruptly ended at 10.2 cal kyr BP (˜8.8 14C kyr BP) with the resumption of biogenic sedimentation. The Olympia Interstade is represented by an interval of hemipelagic sedimentation between ˜43 and 31.5 ka. Prior to ˜45 ka sediment deposition is controlled by glaciomarine processes with evidence for a significant IRD event at ˜47 cal kyr BP (>41±1.06 14C kyr BP).

  3. Theoretical investigation on the inclusion of TCDD with {beta}-cyclodextrin by performing QM calculations and MD simulations

    Energy Technology Data Exchange (ETDEWEB)

    Pan, Wenxiao [Key Lab of Colloid and Interface Chemistry, Ministry of Education, Institute of Theoretical Chemistry, Shandong University, Jinan 250100 (China); Zhang, Dongju, E-mail: zhangdj@sdu.edu.cn [Key Lab of Colloid and Interface Chemistry, Ministry of Education, Institute of Theoretical Chemistry, Shandong University, Jinan 250100 (China); Zhan, Jinhua [Key Lab of Colloid and Interface Chemistry, Ministry of Education, Institute of Theoretical Chemistry, Shandong University, Jinan 250100 (China)

    2011-09-15

    Highlights: {yields} We study the inclusion mechanism of TCDD with {beta}-CD by theoretical methods. {yields} Clearly, the formation of inclusion complex is an energetically driven process. {yields} The inclusion complex can be detected by IR and Raman techniques. {yields} The results imply that {beta}-CD may be used as a host molecule to enrich TCDD molecules. - Abstract: The rapid enrichment and detection of trace polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) are currently challenging issues in the field of environmental science. In this paper, by performing quantum chemistry (QM) calculations and molecular dynamics (MD) simulations, we studied the inclusion complexation of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a representative PCDD molecule, with {beta}-cyclodextrin ({beta}-CD), one of the widely used compounds in supramolecular chemistry. The calculated results reveal that the stable inclusion complex can be formed in both the gas phase and solvent, which proposes that {beta}-CD may serve as a potential substrate enriching TCDD. The calculated vibrational spectra indicate that the infrared (IR) and Raman spectroscopy may be suitable for the detection of {beta}-CD-modified TCDD. The present theoretical results may be informative to environmental scientists who are devoting themselves to developing effective methods for detection and treatment of POPs.

  4. LDRD Final Report (08-ERD-037): Important Modes to Drive Protein MD Simulations to the Next Conformational Level

    Energy Technology Data Exchange (ETDEWEB)

    Sadigh, B

    2011-04-07

    Every action in biology is performed by dynamic proteins that convert between multiple states in order to engage their functions. Often binding to various ligands is essential for the rates of desired transitions to be enhanced. The goal of computational biology is to study these transitions and discover the different states to fully understand the protein's normal and diseased function, design drugs to target/bias specific states, and understand all of the interactions in between. We have developed a new methodology that is capable of calculating the absolute free energy of proteins while taking into account all the interactions with the solvent molecules. The efficiency of the new scheme is an order of magnitude greater than any existing technique. This method is now implemented in the massively parallel popular MD program package NAMD. This now makes it possible to calculate the relative stability of different conformational states of biological macromolecules as well as their binding free energies to various ligands.

  5. Monovalent Ions and Water Dipoles in Contact with Dipolar Zwitterionic Lipid Headgroups-Theory and MD Simulations

    Directory of Open Access Journals (Sweden)

    Aljaž Velikonja

    2013-01-01

    Full Text Available The lipid bilayer is a basic building block of biological membranes and can be pictured as a barrier separating two compartments filled with electrolyte solution. Artificial planar lipid bilayers are therefore commonly used as model systems to study the physical and electrical properties of the cell membranes in contact with electrolyte solution. Among them the glycerol-based polar phospholipids which have dipolar, but electrically neutral head groups, are most frequently used in formation of artificial lipid bilayers. In this work the electrical properties of the lipid layer composed of zwitterionic lipids with non-zero dipole moments are studied theoretically. In the model, the zwitterionic lipid bilayer is assumed to be in contact with aqueous solution of monovalent salt ions. The orientational ordering of water, resulting in spatial variation of permittivity, is explicitly taken into account. It is shown that due to saturation effect in orientational ordering of water dipoles the relative permittivity in the zwitterionic headgroup region is decreased, while the corresponding electric potential becomes strongly negative. Some of the predictions of the presented mean-field theoretical consideration are critically evaluated using the results of molecular dynamics (MD simulation.

  6. Atomistic MD simulations reveal the protective role of cholesterol in dimeric beta-amyloid induced disruptions in neuronal membrane mimics

    Science.gov (United States)

    Qiu, Liming; Buie, Creighton; Cheng, Sara; Chou, George; Vaughn, Mark; Cheng, K.

    2011-10-01

    Interactions of oligomeric beta-amyloid peptides with neuronal membranes have been linked to the pathogenesis of Alzheimer's disease (AD). The molecular details of the interactions of different lipid components, particularly cholesterol (CHOL), of the membranes with the peptides are not clear. Using an atomistic MD simulations approach, the water permeability barrier, structural geometry and order parameters of binary phosphatidylcholine (PC) and PC/CHOL lipid bilayers were examined from various 200 ns-simulation replicates. Our results suggest that the longer length dimer (2 x 42 residues) perturbs the membrane more than the shorter one (2 x 40 residues). In addition, we discovered a significant protective role of cholesterol in protein-induced disruptions of the membranes. The use of a new Monte-Carlo method in characterizing the structures of the conformal annular lipids in close proximity with the proteins will be introduced. We propose that the neurotoxicity of beta-amyloid peptide may be associated with the nanodomain or raft-like structures of the neuronal membranes in-vivo in the development of AD.

  7. Degradation of the Adhesive Properties of MD-944 Diode Tape by Simulated Low Earth Orbit Environmental Factors

    Science.gov (United States)

    Albyn, K.; Finckenor, M.

    2006-01-01

    The International Space Station (ISS) solar arrays utilize MD-944 diode tape with silicone pressure-sensitive adhesive to protect the underlying diodes and also provide a high-emittance surface. On-orbit, the silicone adhesive will be exposed and ultimately convert to a glass-like silicate due to atomic oxygen (AO). The current operational plan is to retract ISS solar array P6 and leave it stored under load for a long duration (6 mo or more). The exposed silicone adhesive must not cause the solar array to stick to itself or cause the solar array to fail during redeployment. The Environmental Effects Branch at Marshall Space Flight Center, under direction from the ISS Program Office Environments Team, performed simulated space environment exposures with 5-eV AO, near ultraviolet radiation and ionizing radiation. The exposed diode tape samples were put under preload and then the resulting blocking force was measured using a tensile test machine. Test results indicate that high-energy AO, ultraviolet radiation, and electron ionizing radiation exposure all reduce the blocking force for a silicone-to-silicone bond. AO exposure produces the most significant reduction in blocking force

  8. Theoretical investigation on the inclusion of TCDD with β-cyclodextrin by performing QM calculations and MD simulations

    International Nuclear Information System (INIS)

    Highlights: → We study the inclusion mechanism of TCDD with β-CD by theoretical methods. → Clearly, the formation of inclusion complex is an energetically driven process. → The inclusion complex can be detected by IR and Raman techniques. → The results imply that β-CD may be used as a host molecule to enrich TCDD molecules. - Abstract: The rapid enrichment and detection of trace polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) are currently challenging issues in the field of environmental science. In this paper, by performing quantum chemistry (QM) calculations and molecular dynamics (MD) simulations, we studied the inclusion complexation of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a representative PCDD molecule, with β-cyclodextrin (β-CD), one of the widely used compounds in supramolecular chemistry. The calculated results reveal that the stable inclusion complex can be formed in both the gas phase and solvent, which proposes that β-CD may serve as a potential substrate enriching TCDD. The calculated vibrational spectra indicate that the infrared (IR) and Raman spectroscopy may be suitable for the detection of β-CD-modified TCDD. The present theoretical results may be informative to environmental scientists who are devoting themselves to developing effective methods for detection and treatment of POPs.

  9. Understanding self-assembly of charged-neutral block copolymer (BCP) and surfactant complexes using molecular dynamics (MD) simulation

    Science.gov (United States)

    Goswami, Monojoy; Sumpter, Bobby; Kilbey, Michael

    Here we report the formation of phase separated BCP-surfactant complexes resulting from the electrostatic self-assembly of charge-neutral block copolymers with oppositely charged surfactants. Complexation behaviors of oppositely charged polyelectrolytes has gained considerable attention in the field of soft condensed matter physics due to their potential application as functional nanomaterials for batteries, wastewater treatment and drug delivery systems. Numerous experiments have examined the self-assembled structures resulting from complexation of charge-neutral BCP and surfactants, however, there is a lack of comprehensive understanding at the fundamental level. To help bridge this gap, we use, MD simulations to study self-assembly and dynamics of the BCP-surfactant complex at the molecular level. Our results show an overcharging effect in BCPs with hydrophobic neutral blocks and a formation of core-shell colloidal structure. Hydrophilic neutral blocks, on the other hand, show stable, hairy colloidal structures with neutral blocks forming a loosely-bound, fuzzy outer layer. Our results qualitatively agree with previous SANS and SAXS experiments. This work was supported by the U.S. Department of Energy (DOE), Office of Basic Energy Sciences, Materials Science and Engineering Division.

  10. Carbon nanoscroll from C4H/C4F-type graphene superlattice: MD and MM simulation insights.

    Science.gov (United States)

    Liu, Zilong; Xue, Qingzhong; Tao, Yehan; Li, Xiaofang; Wu, Tiantian; Jin, Yakang; Zhang, Zhongyang

    2015-02-01

    Morphology manipulation opens up a new avenue for controlling and tailoring the functional properties of graphene, enabling the exploration of graphene-based nanomaterials. Through mixing single-side-hydrogenated graphene (C4H) with fluorinated graphene (C4F) on one single sheet, the C4H/C4F-type graphene superlattices can self-scroll at room temperature. We demonstrate using molecular dynamic (MD) simulations that different proportions, sizes, directions of hydrogenation and fluorination, and geometry of graphene have a great influence on the self-scrolling of superlattices into a variety of well-defined carbon nanoscrolls (CNSs), thus providing a controllable approach to tune their structures. Based on molecular mechanics (MM) simulations, the CNSs bear more than eight times the radial pressure than that of their multiwalled carbon nanotube (MWNT) counterparts, and an excellent radial elasticity of CNSs is also shown. Compared with conventional CNSs, these novel CNSs are endowed with more ample and flexible heterogeneous structures due to the on-demand hydrogenation and fluorination. Besides, this work provides a feasible route to achieve the necessary electronic and optical changes to be applied in graphene device applications.

  11. SURVEY, Baltomore City, MD

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The field survey data for this coastal study includes a field report that exhibits photos and transect information collected in the field survey phase of the study....

  12. SURVEY, Caroline COUNTY, MD

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The field survey data for this coastal study includes a field report that exhibits photos and transect information collected in the field survey phase of the study....

  13. SURVEY, Somerset COUNTY, MD

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The field survey data for this coastal study includes a field report that exhibits photos and transect information collected in the field survey phase of the study....

  14. SURVEY, CHARLES COUNTY, MD

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The field survey data for this coastal study includes a field report that exhibits photos and transect information collected in the field survey phase of the study....

  15. SURVEY, Cecil County, MD

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The field survey data for this coastal study includes a field report that exhibits photos and transect information collected in the field survey phase of the study....

  16. SURVEY, Dorchester County, MD

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The field survey data for this coastal study includes a field report that exhibits photos and transect information collected in the field survey phase of the study....

  17. SURVEY, CALVERT COUNTY, MD

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The field survey data for this coastal study includes a field report that exhibits photos and transect information collected in the field survey phase of the study....

  18. SURVEY, Baltomore County, MD

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The field survey data for this coastal study includes a field report that exhibits photos and transect information collected in the field survey phase of the study....

  19. SURVEY, KENT COUNTY, MD

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The field survey data for this coastal study includes a field report that exhibits photos and transect information collected in the field survey phase of the study....

  20. ORTHOIMAGERY, Cecil County, MD

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Digital orthographic imagery datasets contain georeferenced images of the Earth's surface, collected by a sensor in which object displacement has been removed for...

  1. BASEMAP, CAROLINE COUNTY, MD

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — FEMA Framework Basemap datasets comprise six of the seven FGDC themes of geospatial data that are used by most GIS applications (Note: the seventh framework theme,...

  2. FLOODPLAIN, Caroline County, MD

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The Floodplain Mapping/Redelineation study deliverables depict and quantify the flood risks for the study area. The primary risk classifications used are the...

  3. FLOODPLAIN, Charles County, MD

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The Floodplain Mapping/Redelineation study deliverables depict and quantify the flood risks for the study area. The primary risk classifications used are the...

  4. Detection of the bovine viral diarrhoea/mucosal disease (BVD/MD) virus in tissues from aborted ruminant foetuses using immunohistochemistry.

    Science.gov (United States)

    Njiro, S M; Nkosi, C M

    2009-12-01

    Various tissues from aborted ruminant foetuses were collected, fixed in formalin and embedded in paraffin wax. Sections were made and exposed to a primary monoclonal antibody against the bovine viral diarrhoea/mucosal disease (BVD/MD) virus, and subsequently to a goat anti-mouse secondary antibody conjugated to horse radish peroxidase (HRP). Diaminobenzidine (DAB) was the substrate and it released a brown pigment in the tissues on reacting with the HRP in an immunohistochemistry (IHC) procedure. Of 27 aborted foetuses, an immunoperoxidase staining reaction was observed in 1 ovine and 5 bovine foetuses. The IHC procedure located BVD/MD viral antigen in a wide variety of foetal tissues including cerebral cortical neurons, the pseudostratified columnar epithelial cells lining the bronchi, alveolar lining cells and alveolar macrophages, hepatocytes, renal tubular lining cells and the Purkinje fibres in the myocardium. PMID:20458863

  5. Reaction mechanism of Ru(II) piano-stool complexes: umbrella sampling QM/MM MD study.

    Science.gov (United States)

    Futera, Zdeněk; Burda, Jaroslav V

    2014-07-15

    Biologically relevant interactions of piano-stool ruthenium(II) complexes with ds-DNA are studied in this article by hybrid quantum mechanics-molecular mechanics (QM/MM) computational technique. The whole reaction mechanism is divided into three phases: (i) hydration of the [Ru(II) (η(6) -benzene)(en)Cl](+) complex, (ii) monoadduct formation between the resulting aqua-Ru(II) complex and N7 position of one of the guanines in the ds-DNA oligomer, and (iii) formation of the intrastrand Ru(II) bridge (cross-link) between two adjacent guanines. Free energy profiles of all the reactions are explored by QM/MM MD umbrella sampling approach where the Ru(II) complex and two guanines represent a quantum core, which is described by density functional theory methods. The combined QM/MM scheme is realized by our own software, which was developed to couple several quantum chemical programs (in this study Gaussian 09) and Amber 11 package. Calculated free energy barriers of the both ruthenium hydration and Ru(II)-N7(G) DNA binding process are in good agreement with experimentally measured rate constants. Then, this method was used to study the possibility of cross-link formation. One feasible pathway leading to Ru(II) guanine-guanine cross-link with synchronous releasing of the benzene ligand is predicted. The cross-linking is an exergonic process with the energy barrier lower than for the monoadduct reaction of Ru(II) complex with ds-DNA. PMID:24865949

  6. Reaction mechanism of Ru(II) piano-stool complexes: umbrella sampling QM/MM MD study.

    Science.gov (United States)

    Futera, Zdeněk; Burda, Jaroslav V

    2014-07-15

    Biologically relevant interactions of piano-stool ruthenium(II) complexes with ds-DNA are studied in this article by hybrid quantum mechanics-molecular mechanics (QM/MM) computational technique. The whole reaction mechanism is divided into three phases: (i) hydration of the [Ru(II) (η(6) -benzene)(en)Cl](+) complex, (ii) monoadduct formation between the resulting aqua-Ru(II) complex and N7 position of one of the guanines in the ds-DNA oligomer, and (iii) formation of the intrastrand Ru(II) bridge (cross-link) between two adjacent guanines. Free energy profiles of all the reactions are explored by QM/MM MD umbrella sampling approach where the Ru(II) complex and two guanines represent a quantum core, which is described by density functional theory methods. The combined QM/MM scheme is realized by our own software, which was developed to couple several quantum chemical programs (in this study Gaussian 09) and Amber 11 package. Calculated free energy barriers of the both ruthenium hydration and Ru(II)-N7(G) DNA binding process are in good agreement with experimentally measured rate constants. Then, this method was used to study the possibility of cross-link formation. One feasible pathway leading to Ru(II) guanine-guanine cross-link with synchronous releasing of the benzene ligand is predicted. The cross-linking is an exergonic process with the energy barrier lower than for the monoadduct reaction of Ru(II) complex with ds-DNA.

  7. Evidence of dynamic crossover phenomena in water and other glass-forming liquids: experiments, MD simulations and theory

    Energy Technology Data Exchange (ETDEWEB)

    Chen, S H; Zhang, Y; Lagi, M [Department of Nuclear Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Chong, S H [Institute for Molecular Science, Okazaki 444-8585 (Japan); Baglioni, P [Department of Chemistry and CSGI, University of Florence, Sesto Fiorentino, I-50019 Florence (Italy); Mallamace, F, E-mail: sowhsin@mit.ed [Dipartimento di Fisica, Universita di Messina and IRCCS Neurolesi ' Bonino-Pulejo' , I-98166 Messina (Italy)

    2009-12-16

    In a recent quasi-elastic neutron scattering experiment on water confined in a Portland cement paste, we find that this 3D confined water shows a dynamic crossover phenomenon at T{sub L} = 227 +- 5 K. The DSC heat-flow scan upon cooling and an independent measurement of specific heat at constant pressure of confined water in silica gel show a prominent peak at the same temperature. We show in this paper that this type of behavior is common to many other glassy liquids, which also show the crossover temperature in coincidence with the temperature of a small specific heat peak. We also demonstrate with MD simulations that the dynamic crossover phenomenon in confined water is an intrinsic property of bulk water, and is not due to the confinement effect. Recently, an extended version of the mode coupling theory (MCT) including the hopping effect was developed. This theory shows that, instead of a structural arrest transition at T{sub C} predicted by the idealized MCT, a fragile-to-strong dynamic crossover phenomenon takes place instead at T{sub C}, confirming both the experimental and the numerical results. The coherent and incoherent alpha relaxation times can be scaled with the calculated viscosity, showing the same crossover phenomenon. We thus demonstrated with experiments, simulations and theory that a genuine change of dynamical behavior of both water and many glassy liquids happens at the crossover temperature T{sub L}, which is 10-30% higher than the calorimetric glass transition temperature T{sub g}.

  8. Coupling between protonation and conformation in cytochrome c oxidase: Insights from constant-pH MD simulations.

    Science.gov (United States)

    Oliveira, A Sofia F; Campos, Sara R R; Baptista, António M; Soares, Cláudio M

    2016-06-01

    Cytochrome c oxidases (CcOs) are the terminal enzymes of the respiratory chain in mitochondria and most bacteria. These enzymes reduce dioxygen (O(2)) to water and, simultaneously, generate a transmembrane electrochemical proton gradient. Despite their importance in the aerobic metabolism and the large amount of structural and biochemical data available for the A1-type CcO family, there is still no consensually accepted description of the molecular mechanisms operating in this protein. A substantial number of questions about the CcO's working mechanism remain to be answered, including how the protonation behavior of some key residues is modulated during a reduction cycle and how is the conformation of the protein affected by protonation. The main objective of this work was to study the protonation-conformation coupling in CcOs and identify the molecular factors that control the protonation state of some key residues. In order to directly capture the interplay between protonation and conformational effects, we have performed constant-pH MD simulations of an A1-type CcO inserted into a lipid bilayer in two redox states (oxidized and reduced) at physiological pH. From the simulations, we were able to identify several groups with unusual titration behavior that are highly dependent on the protein redox state, including the A-propionate from heme a and the D-propionate from heme a3, two key groups possibly involved in proton pumping. The protonation state of these two groups is heavily influenced by subtle conformational changes in the protein (notably of R481(I) and R482(I)) and by small changes in the hydrogen bond network.

  9. A Contribution to Secure the Routing Protocol "Greedy Perimeter Stateless Routing" Using a Symmetric Signature-Based AES and MD5 Hash

    CERN Document Server

    Erritali, Mohammed; Ouahidi, Bouabid El; 10.5121/ijdps.2011.2509

    2011-01-01

    This work presents a contribution to secure the routing protocol GPSR (Greedy Perimeter Stateless Routing) for vehicular ad hoc networks, we examine the possible attacks against GPSR and security solutions proposed by different research teams working on ad hoc network security. Then, we propose a solution to secure GPSR packet by adding a digital signature based on symmetric cryptography generated using the AES algorithm and the MD5 hash function more suited to a mobile environment.

  10. Comparative analysis of termoscale effects, isomerization and stability of TM-nanoclusters (Pd,Ni,Fe and Si in dependence on interatomic potentials. MD-simulations

    Directory of Open Access Journals (Sweden)

    Galashev А.Е.

    2011-05-01

    Full Text Available Basing on the MD-simulated data the comparison of physicochemical properties of TM-nanoclusters (Pd,Ni,Fe, and Si-nanoparticles has been carried on in the purpose to understand the specificity of structure changes in depending on nature of interatomic bonds and initial structures (fcc, bcc, icosahedral – Ih. MDsimulation of thermic evolution including melting of TM- and Si- clusters was carried on up to 2000K.

  11. Selection of a recombinant Marek's disease virus in vivo through expression of the Marek's EcoRI-Q (Meq)-encoded oncoprotein: characterization of an rMd5-based mutant expressing the Meq of strain RB-1B.

    Science.gov (United States)

    Kumar, Pankaj; Dong, Huimin; Lenihan, Dawn; Gaddamanugu, Syamsundar; Katneni, Upendra; Shaikh, Shireen; Tavlarides-Hontz, Phaedra; Reddy, Sanjay M; Peters, Wachen; Parcells, Mark S

    2012-06-01

    Marek's disease (MD) is a highly contagious viral disease of chickens (Gallus gallus domesticus) caused by MD virus (MDV), characterized by paralysis, neurologic signs, and the rapid onset of T-cell lymphomas. MDV-induced T-cell transformation requires a basic leucine zipper protein called Marek's EcoRI-Q-encoded protein (Meq). We have identified mutations in the coding sequence of Meq that correlated with virus pathotype (virulent, very virulent, and very virulent plus). The aim of this study was to determine whether recombinant viruses could be isolated based on Meq expression through in vivo selection. Chicken embryo fibroblasts (CEFs) were cotransfected with an rMd5 strain-based Meq deletion virus (rMd5deltaMeq) and meq loci from strains representing different pathotypes of MDV. Transfected CEFs were inoculated into chickens in two independent studies. We were able to isolate a single recombinant virus, rMDV-1137, in a contact-exposed chicken. rMDV-1137 had recombined two copies of the meq gene of RB-1B and was found to have pathogenicity similar to both RB-1B and rMd5 parental strains. We found the RB-1B- and rMd5-induced lymphomas showed differences in composition and that rMDV-1137-induced lymphomas were intermediate in their composition. We were able to establish cell lines from both RB-1B- (MDCC-UD35, -UD37) and rMDV-1137 (MDCC-UD36, -UD38)-induced, but not rMd5-induced, lymphomas. To date, no rMd5- or parent Md5-transformed T-cell lines have been reported. Our results suggest that 1) a recombinant MDV can be selected on the basis of oncogenicity; 2) changes in Meq sequence seem to affect tumor composition and the ability to establish cell lines; and 3) in addition to meq, other genomic loci affect MDV pathogenicity and oncogenicity.

  12. A conceptual demonstration of freeze desalination-membrane distillation (FD-MD) hybrid desalination process utilizing liquefied natural gas (LNG) cold energy.

    Science.gov (United States)

    Wang, Peng; Chung, Tai-Shung

    2012-09-01

    The severe global water scarcity and record-high fossil oil price have greatly stimulated the research interests on new desalination technologies which can be driven by renewable energy or waste energy. In this study, a hybrid desalination process comprising freeze desalination and membrane distillation (FD-MD) processes was developed and explored in an attempt to utilize the waste cold energy released from re-gasification of liquefied natural gas (LNG). The concept of this technology was demonstrated using indirect-contact freeze desalination (ICFD) and direct-contact membrane distillation (DCMD) configurations. By optimizing the ICFD operation parameters, namely, the usage of nucleate seeds, operation duration and feed concentration, high quality drinkable water with a low salinity ∼0.144 g/L was produced in the ICFD process. At the same time, using the optimized hollow fiber module length and packing density in the DCMD process, ultra pure water with a low salinity of 0.062 g/L was attained at a condition of high energy efficiency (EE). Overall, by combining FD and MD processes and adopting the optimized operation parameters, the hybrid FD-MD system has been successfully demonstrated. A high total water recovery of 71.5% was achieved, and the water quality obtained met the standard for drinkable water. In addition, with results from specific energy calculation, it was proven that the hybrid process is an energy-saving process and utilization of LNG cold energy could greatly reduce the total energy consumption.

  13. Perspective: PhD scientists completing medical school in two years: looking at the Miami PhD-to-MD program alumni twenty years later.

    Science.gov (United States)

    Koniaris, Leonidas G; Cheung, Michael C; Garrison, Gwen; Awad, William M; Zimmers, Teresa A

    2010-04-01

    Producing and retaining physician-scientists remains a major challenge in advancing innovation, knowledge, and patient care across all medical disciplines. Various programs during medical school, including MD-PhD programs, have been instituted to address the need for continued production of physician-scientists. From 1971 through 1989, 508 students with a prior PhD in the sciences, mathematics, or engineering graduated in two years from an accelerated MD program at the University of Miami School of Medicine. The program, designed to address potential clinical physician shortages rather than physician-scientist shortages, quickly attracted many top-notch scientists to medicine. Many program graduates went to top-tier residencies, pursued research careers in academic medicine, and became academic leaders in their respective fields. A retrospective examination of graduates conducted in 2008-2009 demonstrated that approximately 59% took positions in academic university medical departments, 3% worked for governmental agencies, 5% entered industry as researchers or executives, and 33% opted for private practice. Graduates' positions included 85 full professors, 11 university directors or division heads, 14 academic chairs, 2 medical school deans, and 1 astronaut. Overall, 30% of graduates had obtained National Institutes of Health funding after completing the program. These results suggest that accelerated medical training for accomplished scientists can produce a large number of successful physician-scientists and other leaders in medicine. Furthermore, these results suggest that shortening the medical portion of combined MD-PhD programs might also be considered. PMID:20354390

  14. Prediction and analysis of the structure of hydrated Mn2+, V2+, Ti3 and Cr3 ions by means of the MD simulation methods

    International Nuclear Information System (INIS)

    Classical Molecular dynamics (MD) and hybrid Quantum/Molecular Mechanics-Molecular Dynamics (QM/MM-MD) simulations have been performed to investigate structural properties of Mn(II), V(II), Cr(III) and Ti(III) cations in aqueous solution. The first hydration sphere in QM/MM-MD simulations is treated quantum mechanically, while the rest of the system is described by classical analytical two- and three-body potentials. The results obtained for the first hydration shell from this method are in agreement with experimental data, showing 100 % of 6 fold coordination around the ion in all cases. The results prove that non/additive contributions are mandatory for an accurate description of ion hydration. Within the QM/MM method, the inclusion of a perturbation field describing the remaining system was shown to be an accurate tool for evaluating the first shell structure, and thus to be a good alternative for systems, where the construction of a three-body correction function is difficult or too time-consuming. (author)

  15. Advanced meet-in-the-middle preimage attacks: First results on full tiger, and improved results on MD4 and SHA-2

    DEFF Research Database (Denmark)

    Guo, Jian; Ling, San; Wang, Huaxiong;

    2010-01-01

    in time 2188.8 for finding preimages, and 2188.2 for second-preimages. Both have memory requirement of order 28, which is much less than in any other recent preimage attacks on reduced Tiger. Using pre-computation techniques, the time complexity for finding a new preimage or second-preimage for MD4 can...... now be as low as 278.4 and 2 69.4 MD4 computations, respectively. The second-preimage attack works for all messages longer than 2 blocks. To obtain these results, we extend the meet-in-the-middle framework recently developed by Aoki and Sasaki in a series of papers. In addition to various algorithm......We revisit narrow-pipe designs that are in practical use, and their security against preimage attacks. Our results are the best known preimage attacks on Tiger, MD4, and reduced SHA-2, with the result on Tiger being the first cryptanalytic shortcut attack on the full hash function. Our attacks runs...

  16. Accurate positions of SiO masers in active star-forming regions - Orion-KL, W51-IRS2, and Sagittarius-B2 MD5

    Science.gov (United States)

    Morita, Koh-Ichiro; Hasegawa, Tetsuo; Ukita, Nobuharu; Okumura, Sachiko K.; Ishiguro, Masato

    1992-08-01

    Accurate positional measurements of SiO J = 1-0 masers in active star-forming regions, Orion-KL, W51-IRS2, and Sgr-B2 MD5, were made with the Nobeyama Millimeter Array. Absolute positional accuracies of 0.12-0.6 arcsec were achieved. The SiO maser in W51-IRS2 is located within 0.4 arcsec (0.5 x 10 exp 17 cm at the distance of W51-IRS2) of the strongest H2O masers. In Sgr-B2 MD5, the SiO maser coincides with the strongest H2O masers, most of the strong OH masers, and the peak of radio continuum emission from the ultracompact H II region within 0.7 arcsec (0.8 x 10 exp 17 cm at the distance of Sgr-B2). Peaks of the emission from hot NH3 were found to exist within about 1 arcsec of the SiO masers in both regions. The precise positional coincidence confirms our former conclusion that the SiO masers in W51-IRS2 and Sgr-B2 MD5 are actually associated with the ongoing activity of star formation, as is the case of Orion-KL.

  17. Detection of haplotype mutations of the MD-2 gene promoter associated with Der p2-induced allergy using a nanostructured biosensor

    Directory of Open Access Journals (Sweden)

    Chin YT

    2014-03-01

    Full Text Available Yu-Ting Chin,1 En-Chih Liao,2 Chia-Che Wu,1 Gou-Jen Wang,1,3,4 Jaw-Ji Tsai2 1Department of Mechanical Engineering, National Chung-Hsing University, 2Department of Medical Education and Research, Taichung Veterans General Hospital, 3Graduate Institute of Biomedical Engineering, 4PhD Program in Tissue Engineering and Regenerative Medicine, National Chung-Hsing University, Taichung, Taiwan Abstract: Group 2 allergens (Der p2 have been reported to be a major cause of the human immune response to dust mite allergens. In this study, we have demonstrated for the first time the effective differentiation between haplotype mutation and normal genes in the MD-2 gene promoter using a nanostructured biosensor. A 70-mer gene fragment containing the haplotype of two single nucleotide polymorphisms in the MD-2 gene promoter region was used as a probe to detect haplotype mutations associated with Der p2-induced allergy. Discrimination was achieved using electrochemical impedance spectroscopy. The discrimination experiments employed 30 haplotype mutation samples and 30 normal target samples. The haplotype mutation samples and normal target samples could be clearly discriminated, even using samples produced by a five-cycle polymerase chain reaction process. The time and cost of sample preparation for the polymerase chain reaction process in the clinical setting can thus be reduced. Keywords: haplotype mutation detection, nanostructured biosensor, MD-2 gene promoter, electrochemical impedance spectroscopy

  18. MD5(0,δb,δc,δc)-消息对Pollard's rho搜索算法设计%Design of Pollard's RHO Searching Algorithm for (0,δb,δc,δc)-Messages of MD5

    Institute of Scientific and Technical Information of China (English)

    王珏; 周林; 徐良华

    2011-01-01

    MD5选择前缀碰撞攻击可应用于伪造CA证书等实际攻击中,构造MD5选择前缀碰撞对是攻击MD5的一个重要研究课题.构造MD5选择前缀碰撞消息对时,需要利用高性能计算设备搜索(0,δb,δc,δc,)一消息对,文章用概率方法描述了生日攻击的原理,阐述了利用生日攻击思想搜索(0,δb,δc,δc,)-消息对的Pollard's rho算法和并行Pollard's rho算法,分析了算法的复杂度,最后给出了一组实验数据.

  19. Cloning and Expression Analysis of GlutathioneS-Transferase GeneMdGSTF3 from Apple (Malus domestica)%苹果谷胱甘肽S-转移酶基因MdGSTF3的克隆及其表达分析

    Institute of Scientific and Technical Information of China (English)

    樊连梅; 刘更森; 李思琪; 原永兵

    2015-01-01

    A full-length glutathioneS-transferase gene namedMdGSTF3 was cloned with RT-PCR and RACE-PCR fromMalus domestica cv. ‘Fuji’ peel. The GenBank accession number was KP234026.MdGSTF3was 868 bp in length including 49 bp of 5' untranslated region, 151 bp of 3' untranslated region and 26 bp polyA. It had a coding sequence (CDS) of 642 bp, encoding 213 amino acid residues. This predicted polypeptide includ-ed 19 kinds of amino acids except for cysteine, with the molecular mass of 23.993 kDa, isoelectric point of 6.17. Real-time lfuorescent quantitative PCR analysis showed that the expression level ofMdGSTF3 in stems, leaves, lfowers of striped-red ‘Fuji’ was higher than that of the mutant blushed-red ‘Fuji’, but the expression level of MdGSTF3 in peel and pulp of blushed-red ‘Fuji’ was higher than that of striped-red ‘Fuji’. The most relative expression quantity ofMdGSTF3 from peel and pulp of blushed-red ‘Fuji’ were 46.6% and 22.1% higher than that of striped-red ‘Fuji’ respectively. The results indicated that the expression level ofMdGSTF3was closely related with anthocyanin accumulation and distribution of apple peel.%以‘富士’苹果果皮为试材,利用RT-PCR和RACE-PCR克隆得到1个全长为868 bp的苹果谷胱甘肽S-转移酶基因MdGSTF3全长cDNA序列, GenBank的登录号为KP234026,该基因5'非翻译区49 bp,3'非翻译区151 bp,含有26 bp的PolyA尾,编码区为642 bp,编码213个氨基酸,编码的蛋白质含有19种氨基酸,不含有半胱氨酸Cys,相对分子质量为23.993 kDa,等电点为6.17。氨基酸多重序列比对分析结果表明MdGST与梅的PmGST蛋白(XP_008235026)遗传相似性为83%。实时荧光定量PCR结果表明, MdGSTF3在条红‘富士’的茎、叶和花中表达量高于其突变体片红‘富士’;而在果皮和果肉中,片红‘富士’该基因的表达量高于条红‘富士’;在表达量达到最大值时,片红‘富士’比条红‘富士’分别高出46.6%和22

  20. Local Structure in Terms of Nearest-Neighbor Approach in 1-Butyl-3-methylimidazolium-Based Ionic Liquids: MD Simulations.

    Science.gov (United States)

    Marekha, Bogdan A; Koverga, Volodymyr A; Chesneau, Erwan; Kalugin, Oleg N; Takamuku, Toshiyuki; Jedlovszky, Pál; Idrissi, Abdenacer

    2016-06-01

    Description of the local microscopic structure in ionic liquids (ILs) is a prerequisite to obtain a comprehensive understanding of the influence of the nature of ions on the properties of ILs. The local structure is mainly determined by the spatial arrangement of the nearest neighboring ions. Therefore, the main interaction patterns in ILs, such as cation-anion H-bond-like motifs, cation-cation alkyl tail aggregation, and ring stacking, were considered within the framework of the nearest-neighbor approach with respect to each particular interaction site. We employed classical molecular dynamics (MD) simulations to study in detail the spatial, radial, and orientational relative distribution of ions in a set of imidazolium-based ILs, in which the 1-butyl-3-methylimidazolium (C4mim(+)) cation is coupled with the acetate (OAc(-)), chloride (Cl(-)), tetrafluoroborate (BF4(-)), hexafluorophosphate (PF6(-)), trifluoromethanesulfonate (TfO(-)), or bis(trifluoromethanesulfonyl)amide (TFSA(-)) anion. It was established that several structural properties are strongly anion-specific, while some can be treated as universally applicable to ILs, regardless of the nature of the anion. Namely, strongly basic anions, such as OAc(-) and Cl(-), prefer to be located in the imidazolium ring plane next to the C-H(2/4-5) sites. By contrast, the other four bulky and weakly coordinating anions tend to occupy positions above/below the plane. Similarly, the H-bond-like interactions involving the H(2) site are found to be particularly enhanced in comparison with the ones at H(4-5) in the case of asymmetric and/or more basic anions (C4mimOAc, C4mimCl, C4mimTfO, and C4mimTFSA), in accordance with recent spectroscopic and theoretical findings. Other IL-specific details related to the multiple H-bond-like binding and cation stacking issues are also discussed in this paper. The secondary H-bonding of anions with the alkyl hydrogen atoms of cations as well as the cation-cation alkyl chain

  1. MD study of the finite temperature effects on the phase ordering, stacking fault energy, and edge dislocation core structure in elemental Pu and Pu–Ga alloys

    Energy Technology Data Exchange (ETDEWEB)

    Karavaev, A.V., E-mail: a.v.karavayev@vniitf.ru; Dremov, V.V.

    2015-02-15

    The Modified Embedded Atom Model (MEAM) of elemental plutonium and plutonium–gallium alloys has been tested for its ability to reproduce the correct ordering of the hcp and fcc phases that is crucial from the point of view of molecular dynamics simulation of elastic–plastic phenomena in the material. Stacking fault energy obtained with the MEAM is in agreement with experimental data. Results of the edge dislocation modeling at the ambient conditions evidence for rather wide dislocation core, namely, 5–6 Burgers vectors. The results of the MD simulation have been compared with those obtained early with recently developed Multi State-MEAM potential.

  2. [Juan Marin Rojas M.D., First Professor of History of Medicine at Universidad de Chile and his "Essay about the origin of syphilis"].

    Science.gov (United States)

    Laval, Enrique

    2014-06-01

    Dr. Juan Marín Rojas, M.D., was the first Professor of History of Medicine at Universidad de Chile, navy doctor, diplomat, writer and literary critic. Member of the International Society of History of Medicine, and Correspondent Member for Chile of the "Office de Documentation de Médecine et Pharmacie Militaire", Liege, Belgium, from which his "Essay about the origin of syphilis" is transcribed with interesting historical facts and little known arguments that affirm the non-american origin of syphilis, but "aspire to leave a doubt, given not a contrary conviction".

  3. Influence of the beam-size or MD-effect on particle losses at B-factories PEP-II and KEKB

    CERN Document Server

    Kotkin, G L

    2004-01-01

    For the $e^+ e^- \\to e^+ e^- \\gamma$ process at colliding beams, macroscopically large impact parameters give an essential contribution to the standard cross section. These impact parameters may be much larger than the transverse sizes of the colliding bunches. It means that the standard calculations have to be essentially modify. In the present paper such a beam-size or MD-effect is calculated for bremsstrahlung at B-factories PEP-II and KEKB using the list of nominal parameters from Review of Particle Physics (2002). We find out that this effect reduces beam losses due to bremsstrahlung by about 20%.

  4. Cloning and Bioinformatic Analysis of Metallothionein-like Protein Gene ( MdFjMT2 ) from Apple ( Malus domestica)%苹果金属硫蛋白基因MdFjMT2克隆及生物信息学分析

    Institute of Scientific and Technical Information of China (English)

    樊连梅; 刘更森; 刘成连; 原永兵

    2011-01-01

    An apple EST local database of apple fruit (Malus domestica cv Red Fuji) was constructed by differential screening and a large number of sequencing against the suppression subtractive hybridization cDNA library from M. Domestica cultivar Red Fuji coloring type sports and its wild type. A metallothionein (MT) gene, named MdFjMT2 ( Accession No. HQ730757) was cloned by RT-PCR and splicing of 42 cDNA sequences that were obtained by Blastn searching against the EST local database. The full length cDNA encoding metallothionein gene Md-FJMT2 was 684bp. Including 97bp of 5' untranslated region and 347bp of 3' untranslated region. It had a coding sequence (CDS) of 240 bp. Encoding 79 ami no acid residues. The protein molecular weight was 7.7938 kD and the theoretical pI was 4. 75. Gene MdFjMT2 contained the conserved domains of all known MT. With 14 Cys (C) residues, ranking in the feature of CC,CXC,and CXXC,and locating at protein N terminus and C terminus. The phylo-genetic tree analysis revealed that the amino acids sequence of MdFjMT2 shared higher similarity with Pyrus Pyrifo-lia M. Domestica, and M. Xiaojinensis, but lower similarity with Prunus dulcis, Salix matsudana, and Actinidia delicio-sa. Bioinformatio analysis showed that MdFjMT2 was mainly located in chloroplasts. It had no signal peptide and belonged to the hydrophilic non-transmembrane protein. MdFjMT2 had no functional domains and random coil was the major components of its secondary structure. These results provided information for further structure and functional study of MdFjMT2. The results would be useful to study the functions of gene,and clarify molecular mechanisms of apple coloring.%以红富士苹果(Malus domestica CV Red Fuji)浓红型芽变和其条红母株为试材,构建抑制性差减杂交(Suppression Subtractive Hybridization,SSH)文库,差异筛选SSH-cDNA文库,经过大量测序构建成红富士苹果EST序列本地数据库,对本地数据库进行Blastn检淡,得到42条金属硫蛋白基因Md

  5. Spectroscopy and single-particle structure of the odd- Z heavy elements {sup 255}Lr, {sup 251}Md and {sup 247}Es

    Energy Technology Data Exchange (ETDEWEB)

    Chatillon, A.; Theisen, C.; Bouchez, E.; Clement, E.; Dayras, R.; Goergen, A.; Korten, W.; Le Coz, Y.; Simenel, C.; Bender, M. [CEA Saclay, DSM/DAPNIA/SPhN, Gif-sur-Yvette Cedex (France); Greenlees, P.T.; Eeckhaudt, S.; Grahn, T.; Jones, P.; Julin, R.; Juutinen, S.; Kettunen, H.; Leino, M.; Perkowski, J.; Rahkila, P.; Saren, J.; Scholey, C.; Uusitalo, J. [University of Jyvaeskylae, Department of Physics, P.O. Box 35 (Finland); Auger, G.; Bouriquet, B.; Casandjian, J.M.; Cee, R.; France, G. de; Toureil, R. de; Rejmund, M.; Saint-Laurent, M.G.; Stodel, C.; Villari, A. [GANIL, Boulevard Henri Becquerel, B.P. 55027, Caen Cedex 5 (France); Bastin, J.E.; Herzberg, R.D.; Ikin, P.J.C.; Jones, G.D.; Pritchard, A. [University of Liverpool, Oliver Lodge Laboratory, Department of Physics, Liverpool (United Kingdom); Grevy, S. [LPC, CAEN Cedex (France); Hauschild, K.; Korichi, A.; Lopez-Martens, A.; Siem, S. [CSNSM, Orsay (France); Lukyanov, S.M.; Penionzhkevich, Yu.E.; Sobolev, Yu.G. [Joint Institute for Nuclear Research, Dubna (Russian Federation); Bonche, P. [CEA Saclay, DSM/SPhT, Gif-sur-Yvette Cedex (France)

    2006-11-15

    The odd-Z isotope {sup 255}Lr, its daughter {sup 251}Md and grand-daughter {sup 247}Es were studied in two experiments performed at GANIL and the University of Jyvaeskylae. The {sup 255}Lr nuclei were produced using the cold fusion-evaporation reaction {sup 209}Bi({sup 48}Ca, 2n){sup 255}Lr at a bombarding energy of 217MeV. The single-particle structure and decay properties were investigated using {alpha}, {gamma} and electron spectroscopy. The ground-state spin and parity could be assigned for {sup 255}Lr (1/2{sup -}) and {sup 251}Md (7/2{sup -}). States corresponding to the 7/2{sup +}[633], 7/2{sup -}[514] and 1/2{sup -}[521] Nilsson orbitals were observed. Results are compared to experimental data obtained in neighbouring isotopes and to Hartree-Fock-Bogoliubov calculations using the Skyrme interaction SLy4 and a density-dependent pairing interaction. The position of the 1/2{sup -}[521] orbital from the spherical 2f{sub 5/2} shell is discussed. (orig.)

  6. Steinberg ``AUDIOMAPS" Music Appreciation-Via-Understanding: Special-Relativity + Expectations "Quantum-Theory": a Quantum-ACOUSTO/MUSICO-Dynamics (QA/MD)

    Science.gov (United States)

    Steinberg, R.; Siegel, E.

    2010-03-01

    ``AUDIOMAPS'' music enjoyment/appreciation-via-understanding methodology, versus art, music-dynamics evolves, telling a story in (3+1)-dimensions: trails, frames, timbres, + dynamics amplitude vs. music-score time-series (formal-inverse power- spectrum) surprisingly closely parallels (3+1)-dimensional Einstein(1905) special-relativity ``+'' (with its enjoyment- expectations) a manifestation of quantum-theory expectation- values, together a music quantum-ACOUSTO/MUSICO-dynamics (QA/MD). Analysis via Derrida deconstruction enabled Siegel- Baez ``Category-Semantics'' ``FUZZYICS''=``CATEGORYICS (``SON of 'TRIZ") classic Aristotle ``Square-of-Opposition" (SoO) DEduction-logic, irrespective of Boon-Klimontovich versus Voss- Clark[PRL(77)] music power-spectrum analysis sampling- time/duration controversy: part versus whole, shows that ``AUDIOMAPS" QA/MD reigns supreme as THE music appreciation-via- analysis tool for the listener in musicology!!! Connection to Deutsch-Hartmann-Levitin[This is Your Brain on Music,(2006)] brain/mind-barrier brain/mind-music connection is both subtle and compelling and immediate!!!

  7. Steinberg ``AUDIOMAPS'' Music Appreciation-Via-Understanding: Special-Relativity + Expectations ``Quantum-Theory'': a Quantum-ACOUSTO/MUSICO-Dynamics (QA/MD)

    Science.gov (United States)

    Fender, Lee; Steinberg, Russell; Siegel, Edward Carl-Ludwig

    2011-03-01

    Steinberg wildly popular "AUDIOMAPS" music enjoyment/appreciation-via-understanding methodology, versus art, music-dynamics evolves, telling a story in (3+1)-dimensions: trails, frames, timbres, + dynamics amplitude vs. music-score time-series (formal-inverse power-spectrum) surprisingly closely parallels (3+1)-dimensional Einstein(1905) special-relativity "+" (with its enjoyment-expectations) a manifestation of quantum-theory expectation-values, together a music quantum-ACOUSTO/MUSICO-dynamics(QA/MD). Analysis via Derrida deconstruction enabled Siegel-Baez "Category-Semantics" "FUZZYICS"="CATEGORYICS ('TRIZ") Aristotle SoO DEduction , irrespective of Boon-Klimontovich vs. Voss-Clark[PRL(77)] music power-spectrum analysis sampling-time/duration controversy: part versus whole, shows QA/MD reigns supreme as THE music appreciation-via-analysis tool for the listener in musicology!!! Connection to Deutsch-Hartmann-Levitin[This is Your Brain on Music, (06)] brain/mind-barrier brain/mind-music connection is subtle/compelling/immediate!!!

  8. Emodin ameliorated lipopolysaccharide-induced fulminant hepatic failure by blockade of TLR4/MD2 complex expression in D-galactosamine-sensitized mice.

    Science.gov (United States)

    Yin, Xinru; Gong, Xia; Jiang, Rong; Kuang, Ge; Wang, Bin; Zhang, Li; Xu, Ge; Wan, Jingyuan

    2014-11-01

    Emodin has been reported to possess anti-inflammatory and anti-oxidant activities. The aim of this study was to explore the effect and mechanism of emodin on lipopolysaccharide (LPS)-induced fulminant hepatic failure (FHF) in D-galactosamine (D-GalN)-sensitized mice. Our results showed that pretreatment with emodin inhibited the elevation of plasma aminotransferases, alleviated the hepatic histopathological abnormalities and improved the survival rate of LPS/D-GalN-primed mice. Moreover, emodin markedly attenuated the increased serum and hepatic tumor necrosis factor-α (TNF-α) production, and activated hepatic p38 mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-κB) signal pathways in LPS/D-GalN-challenged mice. Furthermore, using an in vitro experiment, we found that emodin dose-dependently suppressed TNF-α production, dampened AP-1 and NF-κB activation, and blocked toll-like receptor (TLR) 4/myeloid differentiation factor (MD) 2 complex expression in LPS-elicited RAW264.7 mouse macrophage cells. Taken together, these data suggested that emodin could effectively prevent LPS-induced FHF, which might be mediated by inhibition of TNF-α production, deactivation of MAPKs and NF-κB, and blockade of TLR4/MD2 complex expression.

  9. Determining an age for the Inararo Tuff eruption of Mt. Pinatubo, based on correlation with a distal ash layer in core MD97-2142, South China Sea

    Science.gov (United States)

    Ku, Y.-P.; Chen, C.-H.; Newhall, C.G.; Song, S.-R.; Yang, T.F.; Iizuka, Y.; McGeehin, J.

    2008-01-01

    The largest known eruption of Mt. Pinatubo in the late Quaternary was the Inararo Tuff Formation (ITF) eruption, roughly estimated as five times larger than the 1991 eruption. The precise age of the ITF eruption has been uncertain. Here, a correlative of the ITF eruption, Layer D, is identified in marine sediments, and an age obtained. Tephras were identified in core MD97-2142 of Leg II of the IMAGES III cruise in northern offshore of Palawan, southeastern South China Sea (12??41.33???N, 119??27.90???E). On the basis of the geochemical and isotopic fingerprints, Layer D can be correlated with the ITF eruption of the modern Pinatubo-eruption sequence. By means of the MD97-2142 SPECMAP chronology, Layer D was dated at around 81??2 ka. This estimated age of the ITF eruption and tephra Layer D coincides with an anomalously high SO4-2 spike occurring within the 5 millennia from 79 to 84 ka in the GISP2 ice core record. ?? 2007.

  10. A Molecular Dynamics (MD and Quantum Mechanics/Molecular Mechanics (QM/MM Study on Ornithine Cyclodeaminase (OCD: A Tale of Two Iminiums

    Directory of Open Access Journals (Sweden)

    James W. Gauld

    2012-10-01

    Full Text Available Ornithine cyclodeaminase (OCD is an NAD+-dependent deaminase that is found in bacterial species such as Pseudomonas putida. Importantly, it catalyzes the direct conversion of the amino acid L-ornithine to L-proline. Using molecular dynamics (MD and a hybrid quantum mechanics/molecular mechanics (QM/MM method in the ONIOM formalism, the catalytic mechanism of OCD has been examined. The rate limiting step is calculated to be the initial step in the overall mechanism: hydride transfer from the L-ornithine’s Cα–H group to the NAD+ cofactor with concomitant formation of a Cα=NH2+ Schiff base with a barrier of 90.6 kJ mol−1. Importantly, no water is observed within the active site during the MD simulations suitably positioned to hydrolyze the Cα=NH2+ intermediate to form the corresponding carbonyl. Instead, the reaction proceeds via a non-hydrolytic mechanism involving direct nucleophilic attack of the δ-amine at the Cα-position. This is then followed by cleavage and loss of the α-NH2 group to give the Δ1-pyrroline-2-carboxylate that is subsequently reduced to L-proline.

  11. Comparison of the sequence of the secretory glycoprotein A (gA) gene in Md5 and BC-1 strains of Marek's disease virus type 1.

    Science.gov (United States)

    Ihara, T; Kato, A; Ueda, S; Ishihama, A; Hirai, K

    1989-11-01

    DNA fragments containing the secretory glycoprotein A (gA) gene of Marek's disease virus type 1 (MDV1) were cloned from the DNA libraries of very virulent Md5 and virulent BC-1 strains and sequenced. Two open reading frames (ORF1 and ORF2) were identified for both strains. The ORF1 has the potential to code for a protein of 501 amino acids with a molecular weight of 56 kD that contains strong hydrophobic regions in both the amino and carboxyl termini, and nine potential N-linked glycosylation sites, while the ORF2 is capable of coding for a 24-kD protein. These results indicate that the ORF1 codes for the unprocessed form of gA. Between the Md5 and BC-1 strains, only two sequence mismatches exist in the DNA fragment. More differences appear to exist in the gA sequence of the MDV1 GA strain (12), which lacks a strong hydrophobic anchor sequence. Similarities between the predicted amino acid sequences of the MDV1 gA and the proteins of the other herpesviruses such as herpes simplex type I gC, pseudorabies virus gIII, and varicella zoster virus gpV were noted.

  12. A and MdMYB1 allele-specific markers controlling apple (Malus x domestica Borkh.) skin color and suitability for marker-assisted selection.

    Science.gov (United States)

    Zhang, X J; Wang, L X; Chen, X X; Liu, Y L; Meng, R; Wang, Y J; Zhao, Z Y

    2014-01-01

    Pre-selection for fruit skin color at the seedling stage would be highly advantageous, with marker-assisted selection offering a potential method for apple pre-selection. A and MdMYB1 alleles are allele-specific DNA markers that are potentially associated with apple skin color, and co-segregate with the Rf and Rni loci, respectively. Here, we assessed the potential application of these 2 alleles for marker-assisted breeding across 30 diverse cultivars and 2 apple seedling progenies. The red skin color phenotype was usually associated with the MdMYB1-1 allele and A(1) allele, respectively, while the 2 molecular markers provided approximately 91% predictability in the 'Fuji' x 'Cripps Pink' and 'Fuji' x 'Gala' progenies. The results obtained from the 30 cultivars and 2 progenies were consistent for the 2 molecular markers. Hence, the results supported that Rf and Rni could be located in a gene cluster, or even correspond to alleles of the same gene. Our results are consistent with the hypothesis that red/yellow dimorphism is controlled by a monogenic system, with the presence of the red anthocyanin pigmentation being dominant. In addition, our results supported that the practical utilization of the 2 function markers to efficiently and accurately select red-skinned apple cultivars in apple scion breeding programs.

  13. Interaction analysis of HIV-1 antibody 2G12 and Man9GlcNAc2 ligand: Theoretical calculations by fragment molecular orbital and MD methods

    Science.gov (United States)

    Koyama, Yuka; Ueno-Noto, Kaori; Takano, Keiko

    2013-07-01

    In HIV-1 infection, human antibody 2G12 is capable of recognizing the high-mannose glycans on the HIV-1 surface glycoprotein, gp120. To investigate the ligand binding mechanisms of antibody 2G12 with glycans aiming for the contribution to the medications, we carried out classical molecular dynamics (MD) simulations and ab initio fragment molecular orbital (FMO) calculations on the antibody 2G12 complex with its high-mannose ligand. We found that Mannose D1 of the ligand had the largest binding affinity with the antibody, which was well consistent with experimental reports. Furthermore, significant roles of Mannose 4 and 4‧ in the ligand binding were theoretically indicated.

  14. Chronic thromboembolic pulmonary hypertension (CTEPH). Potential role of multidetector-row CT (MD-CT) and MR imaging in the diagnosis and differential diagnosis of the disease

    Energy Technology Data Exchange (ETDEWEB)

    Wirth, G.; Brueggemann, K.; Bostel, T.; Dueber, C.; Kreitner, K.F. [Universitaetsmedizin Mainz (Germany). Dept. of Radiology; Mayer, E. [Kerckhoff Hospital, Bad Nauheim (Germany). Dept. of Thoracic Surgery

    2014-08-15

    Chronic thromboembolic pulmonary hypertension (CTEPH) can be defined as pulmonary hypertension (resting mean pulmonary arterial pressure of 25 mm Hg or more determined at right heart catheterization) with persistent pulmonary perfusion defects. It is a rare, but underdiagnosed disease with estimated incidences ranging from 0.5% to 3.8% of patients after an acute pulmonary embolism (PE), and in up to 10% of those with a history of recurrent PE. CTEPH is the only form of pulmonary hypertension that can be surgically treated leading to normalization of pulmonary hemodynamics and exercise capacity in the vast majority of patients. The challenges for imaging in patients with suspected CTEPH are fourfold: the imaging modality should have a high diagnostic accuracy with regard to the presence of CTEPH and allow for differential diagnosis. It should enable detection of patients suitable for PEA with great certainty, and allow for quantification of PH by measuring pulmonary hemodynamics (mPAP and PVR), and finally, it can be used for therapy monitoring. This overview tries to elucidate the potential role of ECG-gated multidetector CT pulmonary angiography (MD-CTPA) and MR imaging, and summarizes the most important results that have been achieved so far. Generally speaking, ECG-gated MD-CTPA is superior to MR in the assessment of parenchymal and vascular pathologies of the lung, and allows for the assessment of cardiac structures. The implementation of iodine maps as a surrogate for lung perfusion enables functional assessment of lung perfusion by CT. MR imaging is the reference standard for the assessment of right heart function and lung perfusion, the latter delineating typical wedge-shaped perfusion defects in patients with CTEPH. New developments show that with MR techniques, an estimation of hemodynamic parameters like mean pulmonary arterial pressure and pulmonary vascular resistance will be possible. CT and MR imaging should be considered as complementary

  15. Reduced Worries of Hypoglycaemia, High Satisfaction, and Increased Perceived Ease of Use after Experiencing Four Nights of MD-Logic Artificial Pancreas at Home (DREAM4

    Directory of Open Access Journals (Sweden)

    Claudia Ziegler

    2015-01-01

    Full Text Available Aims. This study assesses the impact of using an AP-system at home on fear of hypoglycaemia. In addition, satisfaction and acceptance of the new technology are evaluated. Methods. In a multicentre, multinational study of 75 patients using the MD-Logic AP during four consecutive nights in home setting 59 of them (aged 10–54 years, 54% male, HbA1c 7.89 ± 0.69% [62.72 ± 7.51 mmol/mol], diabetes duration 11.6 ± 8.4 yrs answered standardized questionnaires (HFS, adapted TAM, and AP satisfaction before and after using the AP. Results. After experiencing the AP in home setting worries of hypoglycaemia were significantly reduced (before 1.04 ± 0.53 versus after 0.90 ± 0.63; P=0.017. Perceived ease of use as a measure of acceptance with the AP significantly increased after personal experience (before 4.64 ± 0.94 versus after 5.06 ± 1.09; P=0.002. The overall satisfaction mean score after using the AP was 3.02 ± 0.54 (range 0–4, demonstrating a high level of satisfaction with this technology. Conclusions. The four-night home-based experience of using MD Logic AP was associated with reduced worries of hypoglycaemia, high level of satisfaction, and increased perceived ease of use of the new technology in children, adolescents, and adults.

  16. Dosimetry for small fields in stereotactic radiosurgery using gafchromic MD-V2-55 film, TLD-100 and alanine dosimeters.

    Directory of Open Access Journals (Sweden)

    Guerda Massillon-J L

    Full Text Available This work investigated the suitability of passive dosimeters for reference dosimetry in small fields with acceptable accuracy. Absorbed dose to water rate was determined in nine small radiation fields with diameters between 4 and 35 mm in a Leksell Gamma Knife (LGK and a modified linear accelerator (linac for stereotactic radiosurgery treatments. Measurements were made using Gafchromic film (MD-V2-55, alanine and thermoluminescent (TLD-100 dosimeters and compared with conventional dosimetry systems. Detectors were calibrated in terms of absorbed dose to water in (60Co gamma-ray and 6 MV x-ray reference (10×10 cm(2 fields using an ionization chamber calibrated at a standards laboratory. Absorbed dose to water rate computed with MD-V2-55 was higher than that obtained with the others dosimeters, possibly due to a smaller volume averaging effect. Ratio between the dose-rates determined with each dosimeter and those obtained with the film was evaluated for both treatment modalities. For the LGK, the ratio decreased as the dosimeter size increased and remained constant for collimator diameters larger than 8 mm. The same behaviour was observed for the linac and the ratio increased with field size, independent of the dosimeter used. These behaviours could be explained as an averaging volume effect due to dose gradient and lack of electronic equilibrium. Evaluation of the output factors for the LGK collimators indicated that, even when agreement was observed between Monte Carlo simulation and measurements with different dosimeters, this does not warrant that the absorbed dose to water rate in the field was properly known and thus, investigation of the reference dosimetry should be an important issue. These results indicated that alanine dosimeter provides a high degree of accuracy but cannot be used in fields smaller than 20 mm diameter. Gafchromic film can be considered as a suitable methodology for reference dosimetry. TLD dosimeters are not

  17. Ectopic expression of MdSPDS1 in sweet orange (Citrus sinensis Osbeck reduces canker susceptibility: involvement of H2O2 production and transcriptional alteration

    Directory of Open Access Journals (Sweden)

    Wang Yin

    2011-03-01

    Full Text Available Abstract Background Enormous work has shown that polyamines are involved in a variety of physiological processes, but information is scarce on the potential of modifying disease response through genetic transformation of a polyamine biosynthetic gene. Results In the present work, an apple spermidine synthase gene (MdSPDS1 was introduced into sweet orange (Citrus sinensis Osbeck 'Anliucheng' via Agrobacterium-mediated transformation of embryogenic calluses. Two transgenic lines (TG4 and TG9 varied in the transgene expression and cellular endogenous polyamine contents. Pinprick inoculation demonstrated that the transgenic lines were less susceptible to Xanthomonas axonopodis pv. citri (Xac, the causal agent of citrus canker, than the wild type plants (WT. In addition, our data showed that upon Xac attack TG9 had significantly higher free spermine (Spm and polyamine oxidase (PAO activity when compared with the WT, concurrent with an apparent hypersensitive response and the accumulation of more H2O2. Pretreatment of TG9 leaves with guazatine acetate, an inhibitor of PAO, repressed PAO activity and reduced H2O2 accumulation, leading to more conspicuous disease symptoms than the controls when both were challenged with Xac. Moreover, mRNA levels of most of the defense-related genes involved in synthesis of pathogenesis-related protein and jasmonic acid were upregulated in TG9 than in the WT regardless of Xac infection. Conclusion Our results demonstrated that overexpression of the MdSPDS1 gene prominently lowered the sensitivity of the transgenic plants to canker. This may be, at least partially, correlated with the generation of more H2O2 due to increased production of polyamines and enhanced PAO-mediated catabolism, triggering hypersensitive response or activation of defense-related genes.

  18. Chronic thromboembolic pulmonary hypertension (CTEPH). Potential role of multidetector-row CT (MD-CT) and MR imaging in the diagnosis and differential diagnosis of the disease

    International Nuclear Information System (INIS)

    Chronic thromboembolic pulmonary hypertension (CTEPH) can be defined as pulmonary hypertension (resting mean pulmonary arterial pressure of 25 mm Hg or more determined at right heart catheterization) with persistent pulmonary perfusion defects. It is a rare, but underdiagnosed disease with estimated incidences ranging from 0.5% to 3.8% of patients after an acute pulmonary embolism (PE), and in up to 10% of those with a history of recurrent PE. CTEPH is the only form of pulmonary hypertension that can be surgically treated leading to normalization of pulmonary hemodynamics and exercise capacity in the vast majority of patients. The challenges for imaging in patients with suspected CTEPH are fourfold: the imaging modality should have a high diagnostic accuracy with regard to the presence of CTEPH and allow for differential diagnosis. It should enable detection of patients suitable for PEA with great certainty, and allow for quantification of PH by measuring pulmonary hemodynamics (mPAP and PVR), and finally, it can be used for therapy monitoring. This overview tries to elucidate the potential role of ECG-gated multidetector CT pulmonary angiography (MD-CTPA) and MR imaging, and summarizes the most important results that have been achieved so far. Generally speaking, ECG-gated MD-CTPA is superior to MR in the assessment of parenchymal and vascular pathologies of the lung, and allows for the assessment of cardiac structures. The implementation of iodine maps as a surrogate for lung perfusion enables functional assessment of lung perfusion by CT. MR imaging is the reference standard for the assessment of right heart function and lung perfusion, the latter delineating typical wedge-shaped perfusion defects in patients with CTEPH. New developments show that with MR techniques, an estimation of hemodynamic parameters like mean pulmonary arterial pressure and pulmonary vascular resistance will be possible. CT and MR imaging should be considered as complementary

  19. Adubação N-P-K e o desenvolvimento, produtividade e qualidade dos frutos do abacaxi 'gold' (MD-2

    Directory of Open Access Journals (Sweden)

    André Guarçoni M

    2011-08-01

    Full Text Available O abacaxi Gold (MD-2 tem atraído interesse no Brasil, visando à exportação. No entanto, há poucas informações científicas no País sobre o manejo nutricional dessa cultivar. O presente trabalho teve por objetivo determinar o efeito da adubação com N, P e K no estado nutricional da planta, no desenvolvimento, na produtividade e na qualidade dos frutos do abacaxi MD-2. Foram avaliados os efeitos de cinco doses de N, cinco de P2O5 e cinco de K 2O sobre as características de crescimento da folha D e do fruto, bem como sobre os teores de N, P e K das folhas D e as características de qualidade do fruto. Concluiu-se que as maiores produtividade e massa de fruto foram obtidas com a aplicação de 650,6 kg ha-1 de N e 735,9 kg ha-1 de K2O, correspondendo a 12,7 e 14,4 g/planta de N e K2O, respectivamente. Nesse caso, a indução floral deve ser recomendada quando a folha D apresentar comprimento > 75,5 cm. Os valores das características de qualidade do fruto diminuíram com a aplicação de N e aumentaram com a adição de P e K, sendo que as doses máximas de 205,8 kg ha-1 de P2O5 e 703,4 kg ha-1 de K2O corresponderam a 4,01 e 13,7 g/planta de N e K2O, respectivamente.

  20. Online rapid sampling microdialysis (rsMD) using enzyme-based electroanalysis for dynamic detection of ischaemia during free flap reconstructive surgery.

    Science.gov (United States)

    Rogers, M L; Brennan, P A; Leong, C L; Gowers, S A N; Aldridge, T; Mellor, T K; Boutelle, M G

    2013-04-01

    We describe an enzyme-based electroanalysis system for real-time analysis of a clinical microdialysis sampling stream during surgery. Free flap tissue transfer is used widely in reconstructive surgery after resection of tumours or in other situations such as following major trauma. However, there is a risk of flap failure, due to thrombosis in the flap pedicle, leading to tissue ischaemia. Conventional clinical assessment is particularly difficult in such 'buried' flaps where access to the tissue is limited. Rapid sampling microdialysis (rsMD) is an enzyme-based electrochemical detection method, which is particularly suited to monitoring metabolism. This online flow injection system analyses a dialysate flow stream from an implanted microdialysis probe every 30 s for levels of glucose and lactate. Here, we report its first use in the monitoring of free flap reconstructive surgery, from flap detachment to re-vascularisation and overnight in the intensive care unit. The on-set of ischaemia by both arterial clamping and failure of venous drainage was seen as an increase in lactate and decrease in glucose levels. Glucose levels returned to normal within 10 min of successful arterial anastomosis, whilst lactate took longer to clear. The use of the lactate/glucose ratio provides a clear predictor of ischaemia on-set and subsequent recovery, as it is insensitive to changes in blood flow such as those caused by topical vasodilators, like papaverine. The use of storage tubing to preserve the time course of dialysate, when technical difficulties arise, until offline analysis can occur, is also shown. The potential use of rsMD in free flap surgery and tissue monitoring is highly promising.