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Sample records for benigna mal diagnosticada

  1. Grand Mal Seizure

    Science.gov (United States)

    ... grand mal seizures include: A family history of seizure disorders Any injury to the brain from trauma, a ... the risk of birth defects. If you have epilepsy and plan to become pregnant, work with your ...

  2. Gupta, Dr Chhitar Mal

    Indian Academy of Sciences (India)

    Gupta, Dr Chhitar Mal Ph.D. (Agra), FNA, FNASc, FAMS, FTWAS Council Service: 1998-2000. Date of birth: 1 September 1944. Specialization: Membrane Biology, Bio-organic Chemistry and Molecular Biophysics Address: Distinguished Professor and Infosys Chair, Institute of Bioinformatics & Applied Biotechnology, Room ...

  3. Mal de terre

    CERN Document Server

    Reeves, Hubert

    2003-01-01

    Notre planète va mal: réchauffement climatique, épuisement des ressources naturelles, pollutions des sols et de l'eau provoquées par les industries civiles et guerrières, disparité des richesses, malnutrition des hommes, taux d'extinction effarant des espèces vivantes, etc.

  4. Memoria del mal

    Directory of Open Access Journals (Sweden)

    Semprún, Jorge

    2011-06-01

    Full Text Available In May 2003 the twelfth edition of the «Aranguren Conferences» was held. Jorge Semprún gave three keynote speeches titled «Kant and the Maquis’ rucksack», «The radical evil and the Buchenwald latrines» and «Literature and memory of the evil: from Sartre to Paul Ricoeur», all of them grouped under the generic denomination Memory of Evil. The thread running through the three speeches was Semprún’s experience as a political deportee at Buchenwald concentration camp, so close to the Weimar camp of Schiller and Goethe. There, he could experience the radical evil, but also the brotherhood through the antifascist resistance groups who coordinated the various clandestine political groups at the camp. This experience helped him review some of the philosophical readings he had done as a philosphy student at the Sorbonne, as well as those readings he took an interest in following the end of the war. In this way, Semprún went over various authors (Immanuel Kant, André Malraux, Edmund Husserl, Jacques Maritain, Martin Heidegger, Karl Marx, Hannah Arendt, Jean Paul Sartre, Paul Ricoeur or Primo Levi arguing their relationship with the issue of Evil.

    En mayo de 2003 se celebró la duodécima edición de las «Conferencias Aranguren». Jorge Semprún dictó tres conferencias magistrales tituladas «Kant y la mochila del maquis», «El mal radical y las letrinas de Buchenwald» y «Literatura y memoria del mal: de Sartre a Paul Ricoeur», agrupadas todas ellas bajo el título genérico de Memoria del mal. El hilo conductor de las tres intervenciones fue la experiencia de Semprún como deportado político en el campo de concentración de Buchenwald, tan cercano al Weimar de Schiller y Goethe. Allí pudo experimentar el mal radical, pero también la fraternidad, a través de los grupos de resistencia antifascista que coordinaban en el campo los distintos grupos políticos clandestinos. Esta experiencia le sirvió para repasar las lecturas

  5. Lipomatosis simétrica benigna de la lengua en la enfermedad de Madelung Benign symmetric lipomatosis of the tongue in Madelung’s disease

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    A. López Ceres

    2006-04-01

    Full Text Available La enfermedad de Madelung, o lipomatosis simétrica benigna es una enfermedad rara caracterizada por acúmulos grasos no encapsulados localizados de forma simétrica alrededor de cuello y hombros. Esta enfermedad, afecta predominantemente a hombres en edades comprendidas entre los 30 y 60 años, con una relación hombre:mujer de 15:1. Existe una gran relación con el abuso del alcohol. Las personas no alcohólicas y las mujeres también pueden verse afectadas, aunque de forma más rara. Presentamos el caso de una mujer diagnosticada de Enfermedad de Madelung refiriendo engrosamiento progresivo de la lengua. Presentaba dificultad para tragar, disartria y disnea con el decúbito.Madelung´s disease, or benign symmetric lipomatosis, is an uncommon disease characterized by non-encapsulated accumulations of fat in a symmetric manner around the neck and shoulders. This uncommon disease predominantly affects men between the ages of 30 and 60 and it has a 15:1 ratio. There is a strong correlation with alcohol abuse. Nonalcoholics and women can also be affected although this is rare. We report the case of a woman diagnosed with Madelung’s disease, who described a gradual swelling of the tongue. She had difficulty swallowing, dysarthria and dyspnea while sleeping.

  6. El Gobierno del mal menor

    DEFF Research Database (Denmark)

    Agustin, Oscar Garcia

    2012-01-01

    El Gobierno no aspira a ser bueno ni malo. Se conforma con ser el Gobierno del mal menor, cuyas medidas drásticas y poco populares están destinadas a salvar a los ciudadanos del desastre que no ha llegado todavía pero podría llegar....

  7. Cultura Primária de Explant de Hiperplasia Prostática Benigna

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    Patrícia Borba Martiny

    2014-01-01

    Full Text Available A Hiperplasia Prostática Benigna (HPB é um crescimento patológico e não maligno da próstata causada principalmente pela proliferação exacerbada das células epiteliais e, principalmente, estromais. Essa neoplasia benigna acomete a maioria dos homens de idade avançada, sendo a condição crônica mais prevalente entre a população masculina. Como mostrado em estudos, o desenvolvimento prostático é intimamente dependente da interação entre as variantes celulares estromais e epiteliais presentes nesta glândula. Entretanto, a cocultura de ambos os tipos celulares é de difícil estabelecimento, uma vez que os dois tipos celulares têm diferentes características de adesão à placa de cultivo celular.

  8. Apoyo social percibido y recibido en mujeres diagnosticadas con cáncer de seno

    OpenAIRE

    Rengifo Hincapié, Marcela

    2017-01-01

    Debido a que el cáncer de seno, constituye en la actualidad una enfermedad crónica y en ese sentido, existe cada vez un mayor número de casos de mujeres viviendo con esta patología, surge la necesidad inherente de crear estrategias que contribuyan en brindar una mejor calidad de vida a esta población. Es así como la presente investigación tuvo como objetivo general comprender las valoraciones que realizan mujeres diagnosticadas con cáncer de seno frente al apoyo social percibido y recibido. L...

  9. Relaksasi Progresif terhadap Intensitas Nyeri Post Operasi BPH (Benigna Prostat Hyperplasia

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    Aprina Aprina

    2017-08-01

    Full Text Available Pain is one of the most common complaints in patients after experiencing a surgery. Surgery is a biphasic event against the human body that implies pain management. In post-surgery patients feel severe pain and 75% of patients have unpleasant experiences due to inadequate pain management.Based on the results of activity reports in Dr. Hi. Abdul Moeloek Public Hospital in Lampung Province in July-December 2016 obtained data operation BPH as many as 51 inhabitants. The objective of this research was to find out the effect of progressive relaxation to an intensity of pain for BPH (Benigna Prostate Hyperplasia post-surgery patient. This was a quasi-experiment research by using one group pretest and posttest design. 20 respondent samples were taken by using accidental sampling. Data were collected by using observation sheet and analyzed by using univariate and bivariate analyses with Wilcoxon sign test. The results showed that the mean value of pain before the progressive relaxation therapy equal to 5.20 with standard deviation 0.834. While the mean value of pain scale after it was 3.60 with standard deviation 0.681. Analysis with Wilcoxon sign test derived p-value 0.000 (ρ-value 0.000 < α 0.05, and the conclusion there was a significant effect the mean value of pain in the post-surgery patient’s BPH (Benigna Prostate Hyperplasia after progressive relaxation therapy. The researcher expects that the progressive relaxation therapy can be used by more operational methods.

  10. Endovascular treatment of a basilar artery dissecting aneurysm Fasciculações benignas responsivas à gabapentina

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    Cassiano Mateus Forcelini

    2007-12-01

    Full Text Available Fasciculations are symptoms present in a broad spectrum of conditions, ranging from normal manifestations to motor neuron diseases. They also represent the main picture of benign fasciculation syndrome. We report a case of such syndrome: a 48-years-old woman complaining about fasciculations for three decades who remained with the symptoms even after the compensation of a disclosed hyperthyroidism. The introduction of gabapentin rendered control of her fasciculations. The available data in the literature about the therapeutic approaches for fasciculations are revised, as long as the rare reports of evolution from patients with "benign" fasciculations to cases of amyotrophic lateral sclerosis, underlining the importance of following the patients with fasciculations.Fasciculações são sintomas presentes em um amplo espectro de condições, desde manifestações normais até doenças do neurônio motor. Elas representam também o principal aspecto da síndrome de fasciculações benignas. Relatamos um caso desta síndrome: uma paciente de 48 anos com queixas de fasciculações por três décadas que, mesmo após a compensação de um quadro de hipertireoidismo, permaneceu com os sintomas. A introdução de gabapentina levou a controle das fasciculações. Os dados disponíveis na literatura sobre as abordagens terapêuticas para fasciculações são revisados, assim como os raros relatos de evolução de pacientes com fasciculações "benignas" para casos de esclerose lateral amiotrófica, salientando a importância do seguimento dos pacientes com fasciculações.

  11. El mal de ojo en Toledo

    OpenAIRE

    Salvador Hernández, Pedro Pablo

    2017-01-01

    La presente tesis doctoral estudia el fenómeno del Mal de Ojo en la provincia de Toledo desde una perspectiva antropológica. El trabajo se estructura en tres partes. Por un lado, se analiza el marco general de la antropología médica, la medicina popular, el curanderismo y los síndromes culturales. Por otro lado, se aborda el fenómeno del Mal de Ojo, analizando los síntomas, la etiología, el tratamiento y la prevención de esta enfermedad cultural. La tercera parte recoge cuatro estudios de cas...

  12. Riesgo familiar total en familias con mujeres diagnosticadas con neoplasia de mama

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    Nancy Cecilia Charrys-Bravo

    2017-07-01

    Full Text Available Objetivo: Determinar el riesgo familiar total de las familias con mujeres diagnosticadas con cáncer de mama, que asisten a un centro de salud oncológico en la ciudad de Barranquilla. Materiales y Métodos: El estudio fue de tipo descriptivo, transversal con abordaje cuantitativo. Se utilizó el instrumento Riesgo Familiar Total RFT 5-33. El universo estuvo conformado por familias con mujeres diagnosticadas con cáncer en mama. La muestra fue de 41 familias que integraron a 154 miembros; se abordó el estudio de manera censal, y no por medio de una muestra, porque el acceso a la información de la totalidad de las familia fue viable. Resultados: Los resultados mostraron que las familias, en su mayoría, son de tipo 2. El 68 % de las pacientes categorizan sus familias como amenazadas, el 5 % como familias de alto riesgo y un 27 % de las familias con un bajo riesgo. Conclusiones: Los hallazgos encontrados en esta investigación son importantes para las familias, lo cual permitirá establecer acciones y actividades que logren orientar e implementar procesos de atención específicos con el propósito de cuidar a las familias para que se mantengan sanos en un nivel de bajo riesgo; además, desarrollar controles y seguimiento a aquellas familias que se encuentran en un riesgo alto de amenazas, mediante acciones de promoción y prevención de la enfermedad de una manera amplia. Por lo anterior, se deben emprender programas más agresivos de prevención y promoción, especialmente con las familias que asisten en busca de apoyo médico para este padecimiento; de esta forma, se podrán diagnosticar los casos de forma temprana y proceder al respectivo tratamiento.

  13. Afrontamiento al cáncer de mama en pacientes diagnosticadas.

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    Mónica Moreno Martín

    2017-03-01

    Full Text Available Introducción: El cáncer de mama representa la primera causa de muerte por cáncer en el sexo femenino y aceptar la idea de un cáncer es un asunto difícil de asimilar, por lo que el afrontamiento a esta enfermedad constituye un factor determinante en el transcurso de la misma. Objetivo: Describir el afrontamiento a la enfermedad de pacientes con cáncer de mama en el Servicio de Oncología del Hospital 10 de Octubre de la Habana.  Métodos: Se realizó un estudio observacional, descriptivo y de tipo transversal entre julio y noviembre del 2014. Se empleó el estudio de casos en profundidad. El universo estuvo constituido por 38 pacientes diagnosticadas de cáncer de mama que asistieron a la consulta de oncología. Bajo un diseño muestral no probabilístico de sujetos tipos, se seleccionaron 14 mujeres diagnosticadas de carcinoma de mama. Resultados: Las pacientes utilizaron estilos de afrontamientos centrados en la emoción y en el problema mostrando un ligero predominio en este último. Los recursos personales para el afrontamiento se caracterizaron por creencias positivas de control, creencias de optimismo y de religiosidad, acompañada también de creencias negativas de control externo y de identidad, así como la percepción salud y energía. Conclusiones: Hubo un ligero predominio al uso de estilos de afrontamiento centrados en el problema con estrategias de búsqueda de apoyo social y planificación. Las pacientes con estilos de afrontamiento centrados en las emociones utilizaron estrategias de distanciamiento y autocontrol.

  14. Analysis of refrigerant mal-distribution

    DEFF Research Database (Denmark)

    Kærn, Martin Ryhl; Elmegaard, Brian

    2009-01-01

    to be two straight tubes. The refrigerant maldistribution is then induced to the evaporator by varying the vapor quality at the inlet to each tube and the air-flow across each tube. Finally it is shown that mal-distribution can be compensated by an intelligent distributor, that ensures equal superheat...

  15. EFECTO DE Tropaeolum tuberosum FRENTE A LA HIPERPLASIA PROSTÁTICA BENIGNA INDUCIDA EN RATAS HOLTZMAN

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    Gioliana Aire-Artezano

    2013-01-01

    Full Text Available Objetivo: Evaluar el efecto de Tropaeolum tuberosum(mashua frente a la Hiperplasia Prostática Benigna (HPB y compararlo con finasterida. Métodos: Estudio experimental completo. Se emplearon 30 ratas Holtzman macho de 12 semanas de edad, aleatorizadas y divididas en seis gru- pos: grupo blanco; grupo testosterona; grupo finasterida (0.33mg/kg/rata; y tres grupos dosis, dosis 1 (300mg/kg/rata, dosis 2 (500mg/kg/rata y dosis 3 (800mg/kg/rata tratados con Tropaeolum tuberosum. Se realizó una medición basal del volumen prostático mediante una ecografía transabdominal. La inducción de HPB se realizó con enantato de testosterona (0,083mg/Kg/rata en los grupos dosis, finasterida y testosterona, el día uno y siete. Paralelamente, se administró liofilizado de Tropaeolum tuberosum y finasterida durante 21 días. Para el diagnóstico, se realiza- ron estudios por imágenes, anatomopatológicos e histopatológicos. Resultados: El estudio por imágenes, en relación al incremento del volumen prostático,no arrojó diferencia significativa entre dosis 2 y finasterida; mientras que en relación con la ecogenicidad, dosis 3 presentó similitud cualitativa al finasterida. En el estudio anatomopatológico, no hubo diferencia significativa entre el grupo dosis 3 y el grupo finasterida. Histo- patológicamente, dosis 3 se asemejó cuantitativamente al finasterida. Conclusiones: Se evidenció disminución de la HPB histológicamente y en el estudio por imágenes; sin embargo, ninguna de las dosis mostró efecto superior al finasterida.

  16. Biologia da nidificação de Megachile (Moureapis benigna Mitchell

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    Frederico Teixeira

    2011-11-01

    Abstract. This paper describes the biology, ecology and nest architecture of Megachile (Moureapis benigna Mitchell in trap nests (NA. The NA were installed in five forest fragments of 2.1 to 920ha, and two disturbed areas (pasture and plantation. We used bamboo canes (NB and black cardboard tubes placed on wooden boards (NC to attract nesting females. Bees occupied 17 NA (12 NB - 9 to 21mm in diameter - and 5 NC - 8 to 10mm in four forest fragments forming 26 nests (one to six nests per NB. No nest was founded in disturbed areas. There was no difference between NB and NC related to the size of formed nests (t= 0.31, p= 0.763, df= 25. The number of cells ranged from 1 to 13 per nest, being larger in NB than in NC (t= 2.26, p= 0.033, df= 25. The construction activity occurred during the rainy season (October to March, with no correlation to climate parameters. Emergence (1 to 12 per nest was correlated with humidity (t= 3.013, p= 0.006. Time to adult emergence varied from 1 to 141 days. The sex ratio was 1.8:1 male/female, differing from 1:1 (Χ2= 9.39, p<0.002. The parasites were Coelioxys otomita Cresson and two other species of Coelioxys. The species demonstrates plasticity in nesting substrate, and preference for cavities with diameters larger than 9mm. There is a possible dependence of the species to forest environments, since the higher occurrence of nesting was in forest areas in advanced stages of regeneration.

  17. Familiares de pessoas diagnosticadas com transtornos alimentares: participação em atendimento grupal

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    Laura Vilela e Souza

    Full Text Available O discurso biomédico com foco no diagnóstico frequentemente tem sido utilizado como recurso exclusivo para informar a assistência aos familiares de pessoas diagnosticadas com anorexia nervosa e bulimia nervosa. Este estudo buscou compreender como essas famílias constroem justificativas para participação em um grupo de apoio no contexto de tratamento dos transtornos alimentares. Uma sessão desse grupo, que abordava a temática de nosso interesse, foi analisada com apoio do discurso construcionista social. A análise empreendida destacou os sentidos coproduzidos sobre a ausência de alguns familiares no grupo, a diminuição de frequência de participação dos pais, a função desse grupo no tratamento, a periodicidade ideal de participação da família e a possibilidade de familiares e coordenadores do grupo coconstruírem o espaço conversacional.

  18. Kewenangan Baitul Mal Aceh dalam Pendistribusian Zakat

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    Surya Darma

    2017-08-01

    ABSTRACT: Aceh is a province in Indonesia that is granted a special authority to govern and manage its own government affairs. One of them is zakat as one of the original source of income. Baitul Mal institution is established by qanun (local law to manage the zakat fund. In regard with its management procedure as the original revenue of the area, which is managed by Baitul Mal, is regulated in qanun and governor regulation. Its expenditure or distribution is in accordance with the guidance of the Islamic Sharia, that is, it may only be the part specified in the Qur'an, not for others. One of the forms of its distributions’ forms is the provision of vocational capital to productive zakat recipients through Productive Zakat Management Units. It is done in the form of interest-free loans. It is slightly different, as the zakat must be divided in full without needing to be returned. Although its interest-free loan is legal, it requires further explanation to avoid negative views. The finding shows that in 2013, 2014 and 2015, Baitul Mal Aceh, gains its funds more than expected. It requires careful handling in order to avoid  any problems in the future.

  19. Reabilitação vestibular da vertigem postural paroxística benigna de canal posterior em idosos

    OpenAIRE

    Ana Paula do Rego André

    2003-01-01

    A Reabilitação Vestibular (RV) é um programa de tratamento realizado por exercícios, associado a um conjunto de medidas relacionadas à mudança de hábitos e esclarecimentos sobre os sintomas associados à alteração do equilíbrio. É um método de terapia fisiológico, inócuo e coerente, que pretende trabalhar o paciente vertiginoso aliviando os sintomas e aumentando seu limiar de sensibilidade para a vertigem. A Vertigem Postural Paroxística Benigna (VPPB) é a mais comum das vestibulopatias perifé...

  20. 34. Estenoses traqueais benignas: experiência de um serviço de pneumologia

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    Marina Bonnet

    2003-11-01

    Full Text Available Estudo retrospectivo de oito anos e meio (1995/ Junho 2003 da experiência do Serviço de Pneumologia do Hospital Garcia de Orta em casos de estenose traqueal benigna.Foram estudados 36 doentes, entre os quais três lactentes, na sua maioria do sexo feminino (58%, cuja a média etária é de 51,8 anos, excluindo os lactentes cujas as idades variam entre um e seis meses. Os tipos de estenoses são variados: simples, diafragmas, complexas e casos de traqueobroncomalacia.A etiologia é múltipla salientando-se no entanto a maioria de casos como resultante de complicação da entubação oro/nasotraqueal; são também descritos casos de estenoses idiopáticas, congénitas, pós traqueotomia e pós cirurgia.As atitudes terapêuticas face às estenoses e às suas complicações variaram entre a simples vigilância e a utilização de técnicas mais complexas, nomeadamente, electrocoagulação de alta frequência, laserterapia, crioterapia, dilatação, colocação de próteses e cirurgia. : Retrospective study from eight and half years of experience of the Pulmonology Service of the Hospital Garcia de Orta, in cases of benign tracheal stenosis.Thirty six patients were studied, three of them were infants, the majority were female (58%, being the mean age of 51,8 years, excluded the infants whose ages were between one and six months. The types of stenosis were various: simple, diaphragms, complexes and caused by tracheobronchomalatia.The causes were multiple but we enhance the fact that the majority were a complication of oro/nasotracheal entubation; also are described cases of idiopathic, congenital and post tracheotomy and surgery.The stenosis and complications therapeutics ranged from surveillance and the use of various bronchology techniques and surgery. Palavras-chave: estenose, traqueia, broncologia, Key-words: stenosis, trachea, bronchology

  1. Morbilidad y mortalidad por afecciones benignas del sistema biliar: Nuestra experiencia

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    Jorge Reyes Cardero

    1997-04-01

    Full Text Available Se realizó un estudio descriptivo y prospectivo sobre morbilidad y mortalidad por enfermedades benignas del sistema biliar en 4 266 pacientes operados en el Hospital Provincial Clinicoquirúrgico Docente "Saturnino Lora" de Santiago de Cuba, en el que se precisó la incidencia de diferentes variables. Las enfermedades más frecuentes fueron las colecistitis y colecistosis, en pacientes del sexo femenino, y un número importante de operados superaba los 60 años. Las complicaciones más comúnmente halladas en el período preoperatorio fueron: la litiasis coledociana y la pancreatitis aguda; en el peroperatorio: sobre la vesícula, la vía biliar y el hígado y en el posoperatorio inmediato las inespecíficas, que prevalecieron sobre las específicas. La mortalidad se consideró dentro de límites aceptables, y como causa fundamental de muerte en los ancianos se destaca el síndrome de disfunción múltiple de órganosA descriptive and prospective study on morbidity and mortality of bening diseases of the biliary tract was performed on 4 266 patients operated on at "Saturnino Lora" Provincial Teaching hospital, Santiago de Cuba with the aim of assessing the incidence of different variables. The most frequent diseases were found to be cholecystitis and cholecystosis in female patients, and a great number of surgically treated patients were over 60 years of age. The most frequently complications found within the preoperative period were: cholelithiasis and acute pancreatitis; during the perioperative period the most common were the complications of the gall bladder, the bile duct, and the liver, and during the immediate portoperative period the most frequent complications were found to be nonspecific which prevailed over the specific ones. Mortality rate was considered to be within acceptable limits, and the syndrome of multiple organ failure was found to be the principal cause of death among aged patients

  2. Mal, daño y justicia

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    Carlos THIEBAUT

    2009-11-01

    Full Text Available RESUMEN: Algunas experiencias del siglo XX -Auschwitz, el Gulag, Hiroshima- han vuelto a herir la conciencia ilustrada y replanteado el problema del mal en nuestra cultura. Más que una indagación metafísica sobre la naturaleza del mal, el artículo aboga por un análisis de cómo llegamos a elaborar su experiencia, un proceso que aquí prefiere concebirse como una indagación en torno al daño. Se analizan las estructuras conceptuales, modales y temporales de esa experiencia y, en la segunda parte, se propone la idea de que la elaboración pública del daño es una clave para comprender la dimensión normativa del espacio público.ABSTRACT: Some experiences of the Twentieth Century have, yet again, wounded the Enlightment program and have rephrased the problem of evil in our culture. The article avoids a metaphysical inquiry into the essence of evil and proposes an analysis of how we come to work and elabórate its experience, a process that is here understood as the experience of harm. Its conceptual, modal and temporal structures are analysed and, in its second part, the idea that the public labouring of harm is a clue to understanding the normative dimensión of the public sphere is proposed.

  3. Alteraciones cromosómicas diagnosticadas en sangre periférica

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    Irenia Blanco Pérez

    2013-12-01

    Full Text Available Introducción: el estudio citogenético en linfocitos de sangre periférica es un medio diagnóstico muy solicitado por diferentes especialidades médicas, es utilizado ampliamente para diagnosticar diferentes cromosomopatías de origen genético. Objetivo: describir las principales alteraciones cromosómicas diagnosticadas en sangre periférica en la Provincia de Pinar del Río a partir de enero del año 2007 hasta diciembre del 2011. Material y método: se efectuó un estudio descriptivo de tipo retrospectivo en 831 pacientes que fueron remitidos al Centro Provincial de Genética Médica. La muestra la conformaron 117 pacientes que resultaron positivos al mostrar en su cariotipo hallazgos de cromosomopatías. Se analizaron: el motivo de indicación, la cantidad de diagnósticos realizados, los tipos de anomalías detectadas. Resultados: en el período estudiado se detectaron 68 casos positivos, el orden de frecuencia de las anomalías cromosómicas fue: las aberraciones estructurales (60.6 %, aberraciones numéricas (34.1 % y mosaicos (5.1 %. Las principales alteraciones correspondieron a trisomías, translocaciones y polimorfismos cromosómicos, sobre todo del cromosoma 9. Conclusiones: los resultados de este estudio se comportan de manera similar con los reportados en la bibliografía revisada y confirma la alta prevalencia de alteraciones cromosómicas en la población de Pinar del Río, donde cabe destacar, la importancia del estudio citogenético en sangre periférica a las personas con antecedentes de abortos espontáneos, infertilidad, dismórfias, reordenamientos cromosómicos balanceados, entre otros, con el fin de establecer un diagnóstico certero, oportuno y proporcionar un buen asesoramiento genético.

  4. El estigma en mujeres diagnosticadas con VPH, displasia y cáncer cervicouterino en Hermosillo, Sonora

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    María del Carmen Arellano Gálvez

    2013-01-01

    Full Text Available Nuestro objetivo es indagar sobre las vivencias y percepciones de un grupo de mujeres de una ciudad al norte de México que han sido diagnosticadas con el virus del papiloma humano, displasias y cáncer cervicouterino. Realizamos treinta y cuatro entrevistas cualitativas; se identificó que las mujeres viven la experiencia de diagnóstico como un estigma, pues alude a su sexualidad, fidelidad y creencias religiosas, por lo que ponen en marcha estrategias protectoras para evitar ser estigmatizadas.

  5. Tratamiento farmacológico en la hiperplasia prostática benigna Pharmacological treatment of the benign prostatic hyperplasia

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    Yohani Pérez Guerra

    2011-03-01

    Full Text Available La hiperplasia prostática benigna, enfermedad común en hombres a partir de los 50 años de edad, consiste en el crecimiento benigno e incontrolado de la glándula prostática y produce diversos síntomas del tracto bajo urinario. Su agente causal multifactorial involucra fundamentalmente el incremento de la conversión de testosterona en dihidrotestosterona por acción de la 5 a-reductasa prostática, lo cual desencadena eventos que propician el incremento en el tamaño de la próstata (componente estático y el aumento del tono del músculo liso de vejiga y próstata (componente dinámico regulado por los adrenoreceptores (ADR-a1. El tratamiento farmacológico de la hiperplasia prostática benigna incluye los inhibidores de la 5a-reductasa, antagonistas de ADR-a1, su terapia combinada y la fitoterapia. El objetivo del presente trabajo fue presentar los aspectos más relevantes de la farmacología de los fármacos utilizados en el tratamiento de la hiperplasia prostática benigna y brindar elementos de su eficacia, seguridad y tolerabilidad. Para ello, se realizó una reseña de los diferentes fármacos utilizados en el tratamiento de esta afección, los que fueron clasificados de acuerdo con su mecanismo de acción. Se incluyeron productos de origen natural como los extractos lipídicos del Serenoa repens y Pygeum africanum, así como el D-004, extracto lipídico de los frutos de la Roystonea regia, que ejerce efectos beneficiosos sobre los principales factores causales de la hiperplasia prostática benigna, ya que es un inhibidor de la 5 a-reductasa prostática, un antagonista de los ADR-a1, un inhibidor de la 5-lipooxigenasa y tiene acción antioxidante, lo que evidencia un mecanismo multifactorial. Los resultados hasta el presente indican que el D-004 es seguro y bien tolerado.Benign prostatic hyperplasia is a common disease in over 50 years-old men consisting in uncontrolled and benign growth of prostatic gland that leads to lower urinary

  6. Savoir gérer le mal

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    Michel Maffesoli

    2015-09-01

    Full Text Available Le sens commun, conservatoire immémorial de la sagesse humaine « sait », de savoir incorporé, que le mal, l’ombre, la mort, la douleur sont des caractéristiques essentielles de l’existence en son entièreté. Dès lors les créatures quelles qu’elles soient, sont des manifestations de la vie et, dès lors, méritent une attitude « compassionnelle », fraternelle, parce qu’ensemble elles constituent le flux vital. C’est ainsi que l’on peut comprendre l’utilité sociale de ces divers « mondes intermédiaires » que sont les croyances, religieuses ou philosophiques, au « double », au « daimon », aux esprits et autres figures tutélaires ou effrayantes. Elles aident à vivre, au jour le jour, la souffrance en la communalisant.

  7. Enfermidades diagnosticadas em bezerros na região sul do Rio Grande do Sul

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    Nathalia D. Assis-Brasil

    2013-04-01

    Full Text Available O objetivo deste estudo foi relatar a frequência das enfermidades que ocorrem em bovinos até um ano de idade na área de influência do Laboratório Regional de Diagnóstico (LRD da Faculdade de Veterinária da Universidade Federal de Pelotas (UFPel estabelecendo os principais fatores epidemiológicos associados à ocorrência dessas enfermidades. Foram revisados os protocolos de necropsias realizadas e de materiais de bovinos até um ano de idade, encaminhados ao LRD/UFPel entre 2000 e 2011. Em 35,6% dos casos, os bezerros eram de raças leiteiras e em 33,98% eram animais de raças de corte, 18,3% dos bezerros não tinham raça definida e em 12,1% dos casos não constava a raça no protocolo de necropsia. Os sistemas mais afetados foram o sistema nervoso central (22,7%, o digestivo (18,6% e o respiratório (16,8%. Os diagnósticos foram divididos por faixa etária sendo que 88 bezerros tinham 1-90 dias de idade; 42 casos corresponderam a animais de 4-6 meses; 32 casos corresponderam a bezerros com 7-9 meses e 44 eram bezerros com 10-12 meses de idade. As enfermidades mais frequentemente diagnosticadas nos bezerros de 1-90 dias foram pneumonias, malformações e encefalites/meningoencefalites com 19,3%, 15,9% e 11,3% dos casos, respectivamente. Nos bezerros com 4-6 meses de idade, as pneumonias ocorreram em 16,5% dos casos e o carbúnculo sintomático e as enterites representaram 7,1% dos diagnósticos cada. Nos bezerros de 7-9 meses, as enfermidades mais frequentes foram pneumonias e tétano com 9,3% dos casos e babesiose e parasitoses gastrintestinais com 6,2% cada. Nos bezerros de 10-12 meses a infecção por BoHV-5 representou 13,6% dos casos e as pneumonias, a raiva e as parasitoses foram observadas em 9,% dos casos cada. Com base nos resultados deste trabalho pode-se concluir que as doenças infecciosas relacionadas ao sistema respiratório foram importantes causas de mortalidade em bezerros de todas as faixas etárias na área de influ

  8. O cemitério como espaço devocional: um estudo sobre a devoção a Irmã Benigna (The cemetery as devotional space: a study about the devotion to sister Benigna

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    Ilza Mara Lima

    2013-03-01

    Full Text Available Este artigo pretende analisar os cemitérios como espaço de múltiplas devoções, dentre elas as devoções marginais: as diversas formas com as quais as pessoas cultuam seus mortos, através de seus túmulos. As devoções que são manifestadas perante esses túmulos dentro dos cemitérios demonstram esta prática de fé, que se denomina de devoção marginal. Pessoas comuns que após a morte, ganham a veneração de fieis que lhe pedem a interseção junto ao sagrado, são cultuadas como milagreiras.  Após o pedido realizado, o devoto passa há ornamentar o tumulo do Milagreiro, com Flores, Velas, Ex votos em forma de agradecimento. O túmulo então se torna objeto de veneração e peregrinação. O artigo examina como esta devoção no cemitério do Bonfim, em Belo Horizonte, mais especificamente no túmulo da milagreira Irmã Benigna, auxilia os devotos nos momentos de suas angústias e aflições. Analisa-se como essa devoção se perpetua à margem da crença oficial. Palavras-chave: Morte. Enterramento. Túmulo. Devoção. Irmã Benigna.   Abstract This article analyzes the cemeteries as a place of many devotions, devotions among them marginal. the various ways in which people worship their dead through their graves. The devotions that are manifested before these graves within the cemeteries demonstrate the practice of faith is called the marginal devotion. Ordinary people who are worshiped as a miracle worker. The article examines how this devotion in the cemetery of Bonfim in Belo Horizonte City, more specifically in the miraculous Num Benigna’s Tomb helps the devotees by the time their distress happene. It looks at how devotion is perpetuated the margin of the official belief. Keywords: Death. Burial. Grave. Devotion. Nun Benigna’s. 

  9. Arendt, Eichmann y la banalidad del mal

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    López, Marina

    2010-04-01

    Full Text Available In this text I describe the characteristics that Hannah Arendt attributes to the SS agents through the figure of Eichmann, during the German Nazi regime of the 20th century. According to this characterization, I intend to show, on the one hand, that there is not a break in Arendt’s thought on evil, i.e. from The Origins of Totalitarianism to Eichmann in Jerusalem: a report on the banality of evil, but a continuous line of thought. And, on the other hand, I try to follow the clues that Arendt gives concerning the “banality” that defines the behavior of individuals such as Eichmann. Both premises will permit me to point out what, in my understanding, the banalization of humanity implies, not only in the context of the Jewish Holocaust, but in each of the societies in which the elimination of spontaneity is a reality.

    En el texto se describen las características que Hannah Arendt, a través de la figura de Eichmann, atribuye a los agentes SS durante el régimen nazi alemán de mediados del siglo XX. Con la caracterización se persigue mostrar, en principio, que no hay una ruptura en el pensamiento de Hannah Arendt respecto a su manera de considerar el mal, desde Los orígenes del Totalitarismo hasta Eichmann en Jerusalén, un estudio sobre la banalidad del mal, sino una continuidad y, por otra parte, seguir las pistas que Arendt propone en torno a la “banalidad” que define el comportamiento de individuos como Eichmann. Ambas premisas nos permitirán poner de relieve lo que, a nuestro parecer, implica la banalización de la humanidad no sólo en el contexto del Holocausto judío, sino en cada una de las sociedades en las que la eliminación de la espontaneidad es una realidad.

  10. Intestinal mal-rotation in adults. CT findings

    International Nuclear Information System (INIS)

    Vazquez Munoz, Enrique; Ramiro Ramiro, Esther; Perez Villacastin, Benjamin; Learra Martinez, Maria C.; Franco Lopez, Maria A.

    2004-01-01

    We review 7 adult cases of intestinal mal-rotation who were studied with CT. All patients had a small bowel located in the right hemi abdomen, abnormal location of superior mesenteric vein relative to superior mesenteric artery. Superior mesenteric vein was located anteriorly and to the left of superior mesenteric artery. In patients who suffered intestinal volvulus a 'whirlpool' sign was observed, due to the helicoidal torsion of the intestine and mesentery surrounding superior mesenteric artery. In 3 cases CT demonstrated absence or poor development of the pancreas uncinate process. In 2 patients CT revealed polysplenia. CT played a major role in 3 patients with volvulus as a complication of intestinal mal-rotation. CT also demonstrated unsuspected mal-rotation in one asymptomatic patient. In 3 cases with classic symptoms CT confirmed the intestinal mal-rotation diagnosed by barium studies. (author)

  11. PENGARUH KEBUDAYAAN KONTEMPORER DALAM PERANCANGAN ARSITEKTUR MAL

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    Freddy H. Istanto

    2000-01-01

    Full Text Available Market is traditionally known as the place where the seller and the buyers meet. In its development, it grows to be big shopping centers and even malls. Along with it, the concept of market has also changed within this building. It is not only the place where the transaction between the sellers and the buyers happen but also it expands to be the one where each person has turned to be the "player" in the nowadays "cultural-theatre". Being the designers, the architect is challenged to respond the changing pattern in the society by making use of the building. Abstract in Bahasa Indonesia : Pasar dikenal sebagai tempat dimana penjual dan pembeli bertemu. Dalam perkembangan lebih lanjut muncul pusat-pusat pertokoan yang sangat besar sampai hadirnya shopping-mall. Di dalam bangunan inilah konsep pasar secara tradisional telah berkembang, tidak saja tempat transaksi antara penjual dan pembeli, tetapi telah melebar menjadi tempat dimana setiap individu telah menjadi "pemain" di dalam sebuah teater kebudayaan masa kini. Arsitek sebagai perancang bangunan harus menyikapi perubahan-perubahan perilaku yang terjadi di masyarakat dalam menggunakan bangunannya. Kata kunci: kebudayaan kontemporer, arsitek, arsitektur mal, kebudayaan milenium tiga.

  12. Genomic characterization and linkage mapping of the apple allergen genes Mal d 2 (thaumatin-like protein) and Mal d 4 (profilin)

    NARCIS (Netherlands)

    Gao, Z.S.; Weg, van de W.E.; Schaart, J.G.; Arkel, van G.; Breiteneder, H.; Hoffmann-Sommergruber, K.; Gilissen, L.J.W.J.

    2005-01-01

    Four classes of apple allergens (Mal d 1, ¿2, ¿3 and ¿4) have been reported. By using PCR cloning and sequencing approaches, we obtained genomic sequences of Mal d 2 (thaumatin-like protein) and Mal d 4 (profilin) from the cvs Prima and Fiesta, the two parents of a European reference mapping

  13. AKSESIBILITAS HOTEL HORISON BEKASI DENGAN MAL METROPOLITAN

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    Nadia Nursintia

    2016-03-01

    Full Text Available Abstract - Development of accommodation services is growing very fast, the construction of hotels ranging from low to star property confirms that the business is very profitable and promising. Growing hotel development as the presence and development of tourism in a region. Concept of mix used and are now growing in demand by developers. In addition to shorten the land, its facilities are increasingly in demand, because the concept of developing the land into two business buildings comprising the hotel and mall, can provide ease of access for service users to carry out all the activities that support their activities. Accessibility is a very important thing to be considered for the service users to choose the hotel accommodation that will be flown them. Distance, transportation, facilities, road conditions, and ease of location had been the benchmark and consideration to get a suitable hotel for their activities.   Keyword : Accessibility, Hotel   Abstrak - Perkembangan jasa akomodasi saat ini berkembang sangat cepat, dibangunnya hotel mulai dari hotel rendah hingga bintang menegaskan bahwa bisnis properti ini sangat menguntungkan dan menjanjikan. Pembangunan hotel berkembang seiring hadirnya dan berkembangnya pariwisata di suatu daerah. Konsep mix used pun kini semakin berkembang dan diminati oleh para pengembang. Selain karena mempersingkat lahan, fasilitas nya pun semakin diminati, karena konsep mengembangkan satu lahan menjadi dua bangunan usaha yang terdiri dari hotel dan mal, dapat memberikan kemudahan akses untuk para pengguna jasa untuk melakukan segala aktifitas yang mendukung kegiatannya. Aksesbilitas merupakan hal yang sangat penting yang menjadi pertimbangan bagi para pengguna jasa akomodasi untuk memilih hotel yang akan mereka singgahi. Jarak, transportasi, fasilitas, kondisi jalan, dan kemudahan lokasi lah yang menjadi tolak ukur dan pertimbangan untuk mendapatkan hotel yang cocok bagi kegiatan mereka.   Kata Kunci

  14. Malária grave importada: relato de caso Severe imported malaria: case report

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    Alessandra Alves

    2007-06-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A malária ainda representa um problema de saúde global. A forma grave da doença é causada principalmente por P. falciparum e pode cursar com complicações cerebrais, renais, pulmonares, hematológicas, circulatórias e hepáticas. O objetivo deste estudo foi relatar um caso de paciente portador de malária grave importada. RELATO DO CASO: Paciente do sexo masculino, 30 anos, pardo, filipino, marinheiro, proveniente de embarcação vinda da Nigéria, com história de dor abdominal no hipocôndrio direito, icterícia, febre e rebaixamento do nível de consciência. Os exames laboratoriais de admissão mostraram hiperbilirrubinemia de 50 mg/dL, acidose metabólica grave, trombocitopenia, creatinina de 5,6 mg/dL, leucocitose com desvio até metamielócitos. O escore APACHE II foi de 37, com risco de óbito de 88%. Durante a internação foi diagnosticada malária por P. falciparum pelo teste de gota espessa. Mesmo com tratamento antimalárico adequado, o paciente evoluiu com insuficiência renal aguda necessitando de hemodiálise e síndrome de angústia respiratória aguda (SARA, necessitando de ventilação mecânica (VM, choque refratário tratado com aminas vasoativas, além de quadro hematológico, configurando um caso grave de disfunção de múltiplos de órgãos. Ainda apresentou pneumonia associada à VM e sepse relacionada ao uso de cateteres. Após a alta hospitalar, o paciente não apresentou seqüelas cerebral, pulmonar ou renal. CONCLUSÕES: Dos critérios definidores de malária grave descritos na literatura, o paciente preenchia: insuficiência renal aguda, síndrome da angústia respiratória aguda (SARA, acidose metabólica, alteração do nível de consciência, hemoglobinúria macroscópica, hiperparasitemia e hiperbilirrubinemia, que se relaciona a uma mortalidade maior que 10%, na dependência do tratamento precoce e dos recursos disponíveis. A malária grave exige diagnóstico e tratamento

  15. Las Nuevas Tecnologías en el Tratamiento de la Hipertrofia Benigna de la Próstata

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    Pablo Gómez Martinez

    1993-08-01

    Full Text Available

    Hace unas cuantas semanas apareció en la prensa de la capital una página dedicada a “un nuevo tratamiento de la hipertrofia benigna de la próstata, sin necesidad de operación”, noticia que, naturalmente, despertó un gran interés entre los afectados por esta enfermedad, con la esperanza de librarse de las intervenciones quirúrgica…, clásicas: la prostatectomía a cielo abierto, o la prostatectomía transuretral.

    El despliegue publicitario fue aprovechado por un pequeño grupo de urólogos (olvidándose un poco de la ética profesional para anunciar la adquisición del aparato y ofrecer los servicios al público de esta nueva tecnología, que el cronista anunció como la panacea para curar la enfermedad, sin recurrir a la cirugía y que han continuado promoviendo a través de la televisión.

    Como era de esperarse, los enfermos comenzaron a consultar a sus médicos sobre la bondad y eficacia del nuevo tratamiento.

    Es un hecho que la mayoría de los profesionales no está muy al corriente del método para poder dar un consejo acertado e imparcial. Hemos considerado importante transmitir la información, de manera’ sucinta, sobre la.’, bases del método, su efecto sobre los tejidos, sus indicaciones y contraindicaciones y los resultados obtenidos.

    El tratamiento se basa en la aplicación del calor a través del recto o de la uretra, generado por medio de micro-ondas, y no es otra cosa que una modalidad de termoterapia...

  16. Mal de meleda with congenital cataract: A novel case report

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    Anisha Sethi

    2015-01-01

    Full Text Available Mal de meleda (MdM, a rare autosomal recessive genodermatosis is characterized by erythema and hyperkeratosis of the palms and soles with a sharp demarcation and that progress with age (progrediens and extend to the dorsal aspects of the hands and feet (transgrediens. It has been associated with various conditions albeit rarely with congenial cataract. Ocular lens and the skin have the same embryological origins. We hereby present this novel case report of Mal de meleda in association with congenital posterior subcapsular cataract which to the best of our knowledge has not been reported from India before.

  17. Evolution of mal ABC transporter operons in the Thermococcales and Thermotogales

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    Gogarten J Peter

    2008-01-01

    Full Text Available Abstract Background The mal genes that encode maltose transporters have undergone extensive lateral transfer among ancestors of the archaea Thermococcus litoralis and Pyrococcus furiosus. Bacterial hyperthermophiles of the order Thermotogales live among these archaea and so may have shared in these transfers. The genome sequence of Thermotoga maritima bears evidence of extensive acquisition of archaeal genes, so its ancestors clearly had the capacity to do so. We examined deep phylogenetic relationships among the mal genes of these hyperthermophiles and their close relatives to look for evidence of shared ancestry. Results We demonstrate that the two maltose ATP binding cassette (ABC transporter operons now found in Tc. litoralis and P. furiosus (termed mal and mdx genes, respectively are not closely related to one another. The Tc. litoralis and P. furiosus mal genes are most closely related to bacterial mal genes while their respective mdx genes are archaeal. The genes of the two mal operons in Tt. maritima are not related to genes in either of these archaeal operons. They are highly similar to one another and belong to a phylogenetic lineage that includes mal genes from the enteric bacteria. A unique domain of the enteric MalF membrane spanning proteins found also in these Thermotogales MalF homologs supports their relatively close relationship with these enteric proteins. Analyses of genome sequence data from other Thermotogales species, Fervidobacterium nodosum, Thermosipho melanesiensis, Thermotoga petrophila, Thermotoga lettingae, and Thermotoga neapolitana, revealed a third apparent mal operon, absent from the published genome sequence of Tt. maritima strain MSB8. This third operon, mal3, is more closely related to the Thermococcales' bacteria-derived mal genes than are mal1 and mal2. F. nodosum, Ts. melanesiensis, and Tt. lettingae have only one of the mal1-mal2 paralogs. The mal2 operon from an unknown species of Thermotoga appears to

  18. Inserción de prótesis metálicas autoexpandibles totalmente recubiertas en patología biliar benigna

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    Mariana Omodeo

    Full Text Available RESUMEN Introducción: las enfermedades biliares benignas se han tratado, tradicionalmente, mediante la colocación de prótesis plásticas. Sin embargo, en la actualidad, las prótesis metálicas autoexpandibles totalmente recubiertas están ganando aceptación para el tratamiento de dichas patologías. Objetivo: evaluar la eficacia y las complicaciones de la inserción endoscópica temporal de prótesis metálicas totalmente recubiertas para el tratamiento de patologías biliares benignas. Materiales y métodos: estudio retrospectivo y observacional realizado a partir de una base de datos prospectiva en un centro de tercer nivel entre marzo de 2012 y mayo de 2016. Se incluyeron pacientes a los que se les colocó una prótesis metálica totalmente recubierta por patología benigna de la vía biliar. Se documentaron las indicaciones, las tasas de resolución, las de éxito técnico y los eventos adversos. Resultados: se incluyeron 31 pacientes a los que se insertaron 34 prótesis. Las indicaciones fueron las siguientes: 8 (25% estenosis biliares poscolecistectomía, 11 (31% coledocolitiasis de gran tamaño o múltiple, 3 (8,3% fístulas biliares, 2 (6% estenosis postrasplante hepático, 3 (8,3% estenosis papilares, 2 (6% perforaciones y 2 (6% sangrados. La tasa de éxito global de resolución de la patológica fue del 88%: 87,5% (7/8 en estenosis poscolecistectomía, 73% (8/11 en litiasis gigante, y 100% en el resto de las indicaciones. Se retiraron mediante endoscopia 33 de las 34 tras un promedio de 133 días (rango 10-180 días. No se registraron complicaciones. Conclusión: las prótesis metálicas autoexpandibles totalmente recubiertas son una alternativa efectiva y segura en la resolución de patologías biliares benignas.

  19. Detección y tipificación de virus del papiloma humano en biopsias de carcinoma ductal infiltrante y lesiones benignas de mama en mujeres venezolanas

    OpenAIRE

    Solorzano, Marisé; Bastidas, Marco; Quintero, Militza; Rojas, Lisbeth; Stea, Domingo; Villasmil, Saúl; Acosta, Víctor; Marín, Carmen; Ramírez, Ana; Blanco, Natasha; Cruz, Jhon; Puig, Juan

    2016-01-01

    Objetivo: Realizar la detección y tipificación del virus del papiloma humano (VPH) en muestras de biopsias de tejido mamario con carcinoma ductal infiltrante. Métodos: Estudio descriptivo de corte transversal de 57 biopsias de carcinoma ductal infiltrante, y 41 biopsias de lesiones benignas de mama de pacientes venezolanas, estas fueron evaluadas utilizando la técnica PCR-RFLP en busca de la presencia del genoma del virus de papiloma humano. El riesgo OR fue evaluado mediante análisis estadís...

  20. A zase ta malá povodí...

    Czech Academy of Sciences Publication Activity Database

    Tesař, Miroslav

    2017-01-01

    Roč. 67, č. 8 (2017), s. 33-38 ISSN 1211-0760. [Hydrologie malého povodí 2017. Praha, 18.04.2017-20.04.2017] Institutional support: RVO:67985874 Keywords : small basin * experimental hydrology * water balance * conference * watershed * hydrology * watershed Subject RIV: DA - Hydrology ; Limnology OBOR OECD: Hydrology

  1. Quedas em idosos com Vertigem Posicional Paroxística Benigna Elderly falls associated with benign paroxysmal positional vertigo

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    Fernando Freitas Ganança

    2010-02-01

    Full Text Available Vertigem Posicional Paroxística Benigna (VPPB pode causar quedas, principalmente em pacientes idosos. OBJETIVO: Verificar se o número de quedas em idosos com VPPB diminui após a realização de manobras de reposicionamento de partículas (MRP. MATERIAL E MÉTODO: Estudo retrospectivo em que foram incluídos idosos com VPPB que tenham apresentado queda no último ano. Todos os pacientes submeteram-se à MRP de acordo com o canal semicircular (CSC acometido. Após a abolição da vertigem e do nistagmo de posicionamento, os pacientes foram acompanhados ao longo de 12 meses e investigados em relação ao número de quedas neste período. Para comparar o número de quedas antes e após as MRP utilizou-se avaliação estatística por meio do teste de Wilcoxon. RESULTADOS: Foram incluídos 121 pacientes. Cento e um pacientes apresentaram acometimento do CSC posterior, 16 do lateral e quatro do anterior. Verificou-se redução do número de quedas após as MRP, com diferença estatisticamente significante na amostra geral (pBenign Paroxysmal Positional Vertigo (BPPV can cause falls, especially in the elderly. AIM: to study whether or not elderly patients with BPPV have a reduction on their falls after the particle repositioning maneuver (PRM. MATERIALS AND METHODS: retrospective study including elderly with BPPV who had fall(s during the last year. All patients were submitted to the PRM according to the affected semicircular canal (SCC. After the abolition of positioning vertigo and nystagmus, the patients were submitted to a 12 month follow-up and were investigated about the number of fall(s. Wilcoxon's test was performed to compare the number of fall(s before and after 12 months of the PRM. RESULTS: One hundred and twenty one patients were included in the study. One hundred and one patients presented involvement of the posterior SCC, 16 of the lateral and four of the anterior. We noticed a reduction on the number of falls, with statistically

  2. Epilepsia occipital benigna da infância de início precoce (tipo Panayiotopoulos: aspectos clínicos e eletrencefalográficos evolutivos em 14 crianças Early-onset benign childhood occipital epilepsy (Panayiotopoulos type: clinical and electroencephalographic features in 14 children

    Directory of Open Access Journals (Sweden)

    Lineu Correa Fonseca

    2005-06-01

    Full Text Available Foram estudadas as características evolutivas clínico-eletrencefalográficas de 14 crianças com epilepsia occipital benigna da infância de início precoce (tipo Panayiotopoulos. O tempo médio de segmento foi 50,5 meses. A idade média na primeira crise foi 3,7 anos. O número total de crises foi até 3 crises em 11 casos, numerosas em 3; o período médio entre a primeira e a última crise foi 14,5 meses. Em 4 casos as crises tiveram duração prolongada, constituindo estado de mal parcial. Atividade epileptiforme (AE occipital foi observada em todos os casos no primeiro EEG e, foi também, extra-occipital, em 3 casos. Houve bloqueio da AE occipital, pela abertura dos olhos, em 4 casos; em 3 casos foram observadas, também, pontas evocadas. O EEG normalizou-se em 9 casos, em um período médio de 29 meses.We studied clinical and electroencephalographic features of 14 children, age range of 2 -8 years, with no neurological or neuroradiological evidence of brain damage and with occipital epileptiform activity in the EEG. Seizures were numerous in 3 cases. Age at onset was between 1-7 years. In 4 cases the seizures last for more than 20 min. Spikes were observed in 6 cases and spike and slow-wave complex in 8. Discharges blocking by eyes opening were confirmed in 4 cases. Somatosensory evoked spikes by foot stimulation were observed in 2 cases. Autonomic and versive seizures are the main clinical manifestations of Panayiotopoulos syndrome. Discharges blocking by eyes opening are a less frequent feature.

  3. Ansiedad, depresión y percepción de control en mujeres diagnosticadas con VIH/Sida

    Directory of Open Access Journals (Sweden)

    Marcela Arrivillaga Quintero

    2006-01-01

    Full Text Available En la actualidad mundial se observa un aumento significativo de casos de infección por VIH en mujeres. Las nuevas medicaciones antirretrovirales han logrado avances en cuanto a la cantidad de vida mas no a su calidad ya que variables psicológicas afectan la evoluci ón de la infección. Esta investigación describe la ansiedad, depresión y percepción de control como variables psicológicas que intervienen en el proceso de infección. Dentro de los hallazgos más importantes se encuentra que un considerable número de participantes (23,4% presentó altos niveles de ansiedad. Algunos (10,63% presentaron altos niveles de depresión y en un menor número (6,38% se encontró bajos niveles de Percepci ón de Control. Los resultados de esta última variable están relacionados con conclusiones de otras investigaciones donde se plantea su importancia en factores como: generación de conductas de autocuidado, sensación de autoeficacia, entre otros. Finalmente, se confirmó que la percepción de control es un predictor de salud mental y física. Esta investigación fue de carácter no experimental, de tipo descriptivo-correlacional con diseño transversal y en ella participaron 48 mujeres diagnosticadas con VIH/Sida de la ciudad de Cali, Colombia

  4. Síndrome de Brown bilateral associada com hipermobilidade articular benigna: relato de caso Bilateral Brown's syndrome associated with benign joint hypermobility: a case report

    Directory of Open Access Journals (Sweden)

    David Kirsch

    2007-03-01

    Full Text Available A síndrome de Brown é caracterizada por grande limitação de elevação em adução, elevação ligeiramente diminuída ou normal na abdução, anisotropia em "Y" ou "V", intorção do olho em supraversão e ducção forçada positiva. Sua causa se deve à inelastibilidade do músculo oblíquo superior ou por sua contenção em sua própria bainha. A hipermobilidade articular benigna é doença hereditária do tecido conectivo caracterizada por aumento da mobilidade em diversas articulações. Sua prevalência é muito variável em relação à idade, sexo e etnia, variando de 2 a 35% em homens e de 5 a 57% e mulheres. Neste relato os autores descrevem um caso de síndrome de Brown associada com hipermobilidade articular benigna e atentam para a associação pouco referida na literatura. J.C.S, masculino, 6 anos de idade, pardo, estudante, foi encaminhado à Universidade de Santo Amaro com queixa de exotropia há dois anos que aumentava na supraversão. Paciente com o diagnóstico de síndrome de Brown bilateral teve o diagnóstico de hipermobilidade articular benigna pelo Reumatologista. O paciente com hipermobilidade articular benigna pode desenvolver sintomas articulares como artralgia devido a uma inflamação articular. Acreditamos na possibilidade de que síndrome de Brown possa ter ocorrido devido a processo inflamatório na tróclea que teve início devido a hipermobilidade articular benigna.Brown's syndrome is characterized by a limitation of elevation in adduction, slight or normal limitation of elevation in abduction, divergence in straight upgaze (V-pattern, intorsion in upgaze and positive forced duction. It is caused by a tight or inelastic superior oblique tendon. Benign joint hypermobility is a hereditary disease of the connective tissue characterized by an increase of mobility in diverse joints. Its prevalence is very changeable regarding age range, sex and ethnicity, varying from 2 to 35% in men and 5 to 57% in women. In

  5. Evidence for tension-based regulation of Drosophila MAL and SRF during invasive cell migration.

    Science.gov (United States)

    Somogyi, Kálmán; Rørth, Pernille

    2004-07-01

    Cells migrating through a tissue exert force via their cytoskeleton and are themselves subject to tension, but the effects of physical forces on cell behavior in vivo are poorly understood. Border cell migration during Drosophila oogenesis is a useful model for invasive cell movement. We report that this migration requires the activity of the transcriptional factor serum response factor (SRF) and its cofactor MAL-D and present evidence that nuclear accumulation of MAL-D is induced by cell stretching. Border cells that cannot migrate lack nuclear MAL-D but can accumulate it if they are pulled by other migrating cells. Like mammalian MAL, MAL-D also responds to activated Diaphanous, which affects actin dynamics. MAL-D/SRF activity is required to build a robust actin cytoskeleton in the migrating cells; mutant cells break apart when initiating migration. Thus, tension-induced MAL-D activity may provide a feedback mechanism for enhancing cytoskeletal strength during invasive migration.

  6. Modelling of innovative SANEX process mal-operations

    International Nuclear Information System (INIS)

    McLachlan, F.; Taylor, R.; Whittaker, D.; Woodhead, D.; Geist, A.

    2016-01-01

    The innovative (i-) SANEX process for the separation of minor actinides from PUREX highly active raffinate is expected to employ a solvent phase comprising 0.2 M TODGA with 5 v/v% 1-octanol in an inert diluent. An initial extract / scrub section would be used to extract trivalent actinides and lanthanides from the feed whilst leaving other fission products in the aqueous phase, before the loaded solvent is contacted with a low acidity aqueous phase containing a sulphonated bis-triazinyl pyridine ligand (BTP) to effect a selective strip of the actinides, so yielding separate actinide (An) and lanthanide (Ln) product streams. This process has been demonstrated in lab scale trials at Juelich (FZJ). The SACSESS (Safety of Actinide Separation processes) project is focused on the evaluation and improvement of the safety of such future systems. A key element of this is the development of an understanding of the response of a process to upsets (mal-operations). It is only practical to study a small subset of possible mal-operations experimentally and consideration of the majority of mal-operations entails the use of a validated dynamic model of the process. Distribution algorithms for HNO_3, Am, Cm and the lanthanides have been developed and incorporated into a dynamic flowsheet model that has, so far, been configured to correspond to the extract-scrub section of the i-SANEX flowsheet trial undertaken at FZJ in 2013. Comparison is made between the steady state model results and experimental results. Results from modelling of low acidity and high temperature mal-operations are presented. (authors)

  7. O conceito de mal radical The concept of radical evil

    Directory of Open Access Journals (Sweden)

    Adriano Correia

    2005-01-01

    Full Text Available A noção de mal radical aparece em Kant no contexto da discussão da religião nos limites da simples razão e busca dar conta da complexa relação entre o respeito pela lei moral e o amor-próprio na definição do móbil para a ação. Na busca por identificar o fundamento da propensão para o mal no homem, Kant se vê diante da dificuldade de ter de articular natureza e liberdade, e ainda que a noção de mal radical possa conservar algumas ambigüidades, permite conceber uma noção de responsabilidade compatível com uma inata propensão para o mal. Neste texto busco explicitar alguns passos fundamentais na construção do conceito por Kant.The concept of radical evil appears in Kant's theory when he discusses the religion in the limits of the mere reason and aims explain the complex relationship between respect for the moral law and the self-love, for establish the motive of the action. By aiming identify the basis of human inclination to evil, Kant is faced with the trouble of have to put nature and freedom in connection. Despite of the concept of radical evil retain some ambiguity, it allows conceive a notion of responsibility suitable to an inherent inclination to evil. In this paper is my purpose to explain some basic moments of Kantian formulation of that notion.

  8. Maltose-binding protein effectively stabilizes the partially closed conformation of the ATP-binding cassette transporter MalFGK2

    KAUST Repository

    Weng, Jingwei; Gu, Shuo; Gao, Xin; Huang, Xuhui; Wang, Wenning

    2017-01-01

    Maltose transporter MalFGK2 is a type-I importer in the ATP-binding cassette (ABC) transporter superfamily. Upon the binding of its periplasmic binding protein, MalE, the ATPase activity of MalFGK2 can be greatly enhanced. Crystal structures of the MalFGK2-MalE-maltose complex in a so-called

  9. Maltose-binding protein effectively stabilizes the partially closed conformation of the ATP-binding cassette transporter MalFGK2

    KAUST Repository

    Weng, Jingwei

    2017-02-23

    Maltose transporter MalFGK2 is a type-I importer in the ATP-binding cassette (ABC) transporter superfamily. Upon the binding of its periplasmic binding protein, MalE, the ATPase activity of MalFGK2 can be greatly enhanced. Crystal structures of the MalFGK2-MalE-maltose complex in a so-called

  10. Mucin 1 (MUC1 is a novel partner for MAL2 in breast carcinoma cells

    Directory of Open Access Journals (Sweden)

    McGuckin Michael A

    2009-01-01

    Full Text Available Abstract Background The MAL2 gene, encoding a four-transmembrane protein of the MAL family, is amplified and overexpressed in breast and other cancers, yet the significance of this is unknown. MAL-like proteins have trafficking functions, but their molecular roles are largely obscure, partly due to a lack of known binding partners. Methods Yeast two-hybrid screening of a breast carcinoma cDNA expression library was performed using a full-length MAL2 bait, and subsequent deletion mapping experiments were performed. MAL2 interactions were confirmed by co-immunoprecipitation analyses and confocal microscopy was employed to compare protein sub-cellular distributions. Sucrose density gradient centrifugation of membranes extracted in cold Triton X-100 was employed to compare protein distributions between Triton X-100-soluble and -insoluble fractions. Results The tumor-associated protein mucin 1 (MUC1 was identified as a potential MAL2 partner, with MAL2/MUC1 interactions being confirmed in myc-tagged MAL2-expressing MCF-10A cells using co-immunoprecipitation assays. Deletion mapping experiments demonstrated a requirement for the first MAL2 transmembrane domain for MUC1 binding, whereas the MAL2 N-terminal domain was required to bind D52-like proteins. Confocal microscopy identified cytoplasmic co-localisation of MUC1 and MAL2 in breast cell lines, and centrifugation of cell lysates to equilibrium in sucrose density gradients demonstrated that MAL2 and MUC1 proteins were co-distributed between Triton X-100-soluble and -insoluble fractions. However co-immunoprecipitation analyses detected MAL2/MUC1 interactions in Triton X-100-soluble fractions only. Myc-MAL2 expression in MCF-10A cells was associated with both increased MUC1 detection within Triton X-100-soluble and -insoluble fractions, and increased MUC1 detection at the cell surface. Conclusion These results identify MUC1 as a novel MAL2 partner, and suggest a role for MAL2 in regulating MUC1

  11. Sequential Action of MalE and Maltose Allows Coupling ATP Hydrolysis to Translocation in the MalFGK2 Transporter.

    Science.gov (United States)

    Bao, Huan; Dalal, Kush; Cytrynbaum, Eric; Duong, Franck

    2015-10-16

    ATP-binding cassette (ABC) transporters have evolved an ATP-dependent alternating-access mechanism to transport substrates across membranes. Despite important progress, especially in their structural analysis, it is still unknown how the substrate stimulates ATP hydrolysis, the hallmark of ABC transporters. In this study, we measure the ATP turnover cycle of MalFGK2 in steady and pre-steady state conditions. We show that (i) the basal ATPase activity of MalFGK2 is very low because the cleavage of ATP is rate-limiting, (ii) the binding of open-state MalE to the transporter induces ATP cleavage but leaves release of Pi limiting, and (iii) the additional presence of maltose stimulates release of Pi, and therefore increases the overall ATP turnover cycle. We conclude that open-state MalE stabilizes MalFGK2 in the outward-facing conformation until maltose triggers return to the inward-facing state for substrate and Pi release. This concerted action explains why ATPase activity of MalFGK2 depends on maltose, and why MalE is essential for transport. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  12. Historia de la voluntad y banalidad del mal

    Directory of Open Access Journals (Sweden)

    Prior Olmos, Ángel

    2010-04-01

    Full Text Available This article discusses the connections existing in The Life of the Mind between the theory of the banality of evil and the history of the will. It interprets Eichmann in Jerusalem as a work about bureaucratic evil, but above all as research concerning both moral and juridical responsibility. From the history of the will it highlights three different aspects that can be connected with the problem of responsibility: the ontology of contingency, the idea of individuality linked to the will and the capacity of transcendence and resistance that we see in the Duns Scotus’ theory, where liberty equals indifference. Finally, it suggests a link between the banality of evil and the ontology of good as these are present in “Some questions of moral philosophy” (1965-1966, the fight against Gnosticism and the defense of a relationship between morality and evil’s intelligibility.

    El artículo plantea las conexiones entre la tesis de la banalidad del mal y la historia de la voluntad presente en La vida del espíritu. Interpreta Eichmann en Jerusalén como una obra sobre el mal burocrático, pero sobre todo como estudio acerca de la responsabilidad, tanto jurídica como moral. De la historia de la voluntad resalta tres aspectos que pueden ser puestos en conexión con el problema de la responsabilidad: la ontología de la contingencia, la idea de individualidad vinculada a la voluntad y la capacidad de trascendencia y resistencia subyacentes en la teoría de Duns Escoto de la libertad como indiferencia. Por último, sugiere una vinculación entre la banalidad del mal y la ontología del bien desarrolladas en “Algunas cuestiones de filosofía moral”, de 1965-1966, la lucha contra el gnosticismo y la defensa de una relación entre moralidad e inteligibilidad del mal.

  13. El problema del mal y la violencia en Colombia

    Directory of Open Access Journals (Sweden)

    Victor Eligio Espinosa Galán

    2015-09-01

    Full Text Available La historia de la humanidad está marcada por conflictos de distinta naturaleza: religiosos, ideológicos, raciales, etc., expresados en guerras, ataques terroristas, masacres, entre muchas otras situaciones de crueldad que muestran maldad y sevicia ejercida sobre seres humanos. Ante estos acontecimientos que nos enfrentan a la pregunta: ¿qué es aquello que nos hace humanos?, parece, en un contexto como el colombiano, que se asiste a formas oficiales de una agencia de maldad como posibilidad de un ethos cultural que hace plausibles las acciones más perversas en una desoladora minimización de responsabilidad moral, necesaria para construcción de una sociedad justa y en paz. Este escrito es un esfuerzo por pensar el problema del mal en el contexto de la violencia en Colombia y dar cuenta de algunos aspectos de la reflexión filosófica sobre el mal, el sufrimiento y el sentido de la vida; se toma como contexto el conflicto armado en Colombia y las narraciones de sus protagonistas.

  14. Glucose and maltose metabolism in MIG1-disrupted and MAL-constitutive strains of Saccharomyces cerevisiae

    DEFF Research Database (Denmark)

    Klein, Christopher; Olsson, Lisbeth; Rønnow, B

    1997-01-01

    in a mixed glucose-maltose medium revealed that the MAL-constitutive strains were more alleviated than the single MIG1-disrupted transformant. While all transformants exhibited higher maximum specific growth rates (0.24-0.25 h(-1)) in glucose-maltose mixtures than the wild type strain (0.20 h(-1)), the MAL-constitutive...

  15. Characterization of different crystal forms of the alpha-glucosidase MalA from Sulfolobus solfataricus

    DEFF Research Database (Denmark)

    Ernst, Heidi Asschenfeldt; Willemoës, Martin; Lo Leggio, Leila

    2005-01-01

    MalA is an alpha-glucosidase from the hyperthermophilic archaeon Sulfolobus solfataricus. It belongs to glycoside hydrolase family 31, which includes several medically interesting alpha-glucosidases. MalA and its selenomethionine derivative have been overproduced in Escherichia coli...

  16. Effect of postharvest storage on the expression of the apple allergen Mal d 1

    NARCIS (Netherlands)

    Sancho, Ana I.; Foxall, Robert; Browne, Tom; dey, Rickmer; Zuidmeer, Laurian; Marzban, Gorji; Waldron, Keith W.; van Ree, Ronald; Hoffmann-Sommergruber, Karin; Laimer, Margit; Mills, E. N. Clare

    2006-01-01

    Consumption of fresh apples can cause allergy in susceptible individuals. A competitive enzyme-linked immunosorbent assay (ELISA) has been developed to determine Mal d 1 levels in apple pulp using a monoclonal antibody (BIP-1). The ELISA was able to rank ten cultivars according to their Mal d 1

  17. Epigenetic silencing of MAL, a putative tumor suppressor gene, can contribute to human epithelium cell carcinoma

    Directory of Open Access Journals (Sweden)

    Zhang Jun

    2010-11-01

    Full Text Available Abstract Background To identify new and useful candidate biomarkers in head and neck squamous cell carcinoma (HNSCC, we performed a genome-wide survey and found that Myelin and lymphocyte-associated protein (MAL was a gene that was markedly down-regulated in HNSCC. Hence, we investigated the mechanism of MAL silencing and the effects of MAL on the proliferation, invasion, and apoptotic potential in HNSCC. Results MAL was significantly down-regulated in 91.7% of HNSCC specimens at the mRNA level as compared with adjacent normal tissues (P = 0.0004. Moreover, the relative transcript levels of the MAL gene were remarkably decreased by five-fold in nine HNSCC cell lines as compared with normal head and neck epithelium cells. MAL gene expression was restored in 44%, 67%, and 89% in HNSCC cell lines treated with TSA, 5-Aza-dC, and TSA plus 5-Aza-dC, respectively. Furthermore, bisulfate-treated DNA sequencing demonstrated that the two CpG islands (that is, M1 and M2 located in MAL promoter region were completely methylated in the HNSCC cell lines (CpG methylated ratio was more than 90%, and only one CpG island (that is, M1 was partially methylated in HNSCC tissues (CpG methylated ratio between 20% and 90%. A significant reduction in cell proliferation and a change in the cell cycle profile were also observed in MAL transfectants. Matrigel assay demonstrated that the invasiveness of HNSCC cells significantly decreased. A significant increase in the population of apoptotic cells was observed in MAL transfected cells. The exogenous expression of the MAL gene suppressed malignant phenotypes, while the cell death induced by MAL gene transfer was a result of apoptosis as demonstrated by the induction of cleavage of the poly (that is, ADP-ribose polymerase. Additionally, tumor growth was suppressed in cells expressing MAL as compared with cells not expressing MAL. Conclusion Our data suggest that the epigenetic inactivation of MAL, as a candidate tumor

  18. Fernandez osteotomy of radio distal with mal united fracture

    International Nuclear Information System (INIS)

    Garcia Herrera, Alvaro; Bocanegra, Sergio; Suarez, Fabio

    2003-01-01

    We review prospectively our experience in the military hospital in Bogota, Colombia, with the opening-wedge osteotomy for the treatment of a mal united fracture of the distal end of the radius in fifty-six consecutive patients from 1990 to 2002. The indications for operation were pain predominantly in the radio-ulnar joint and functional limitation with grip strength loss. Preoperative radiographs revealed an average ulnar inclination of 14 degrees, an average ulnar variance of four millimeters, and increased dorsal tilt (colles deformity) that averaged 28 degrees. All patients had limited function. The average grip strength was a force of fifteen kilograms compared with a force of thirty-one kilograms in the contralateral hand. Postoperatively, all of the patients had substantial improvement in function, relief of pain and grip strength increased. The functional results were rated as very good in eleven patients, good in thirty-six, fair in nine

  19. [Clonage of the "malA" region of "Escherichia coli" K12: nucleotide sequence of the regulatory region and the promoters, identification and purification of the MalT-activator protein (author's transl)].

    Science.gov (United States)

    Raibaud, O; Débarbouillé, M; Cossart, P

    1982-01-01

    A 5,800-bp (base pair) HindIII-EcoRI DNA fragment containing malT, the positive regulator gene of the maltose regulon, and most of malP, the structural gene for maltodextrin phosphorylase, was cloned into pBR322. A sequence of 802 bp was established in a DNA segment containing the promotor for malPQ and the promoter for malT. A total of 611 bp separates the initiation codons for these two genes, which are transcribed in opposite directions. The malT product was identified as a 94,000 dalton polypeptide.

  20. Estados de mal epiléptico na sindrome Delennox-Gastaut: aspectos terapeuticos

    Directory of Open Access Journals (Sweden)

    José Geraldo Speciali

    1977-09-01

    Full Text Available Foram descritas as condutas terapêuticas utilizadas nos estados de mal epiléptico, convulsivos e não convulsivos, observados em 14 pacientes com síndrome de Lennox-Gastaut. Verificou-se relação temporal entre aparecimento de estado de mal epiléptico e início de tratamento com clonazepam e difenilhidantoina; a retirada dessas medicações foi seguida pelo desaparecimento dos estados de mal. Indicou-se a possibilidade de tratamento dos estados de mal epiléptico modificando-se o esquema terapêutico administrado por via oral, reservando-se o tratamento parenteral para os estados com comprometimento progressivo da consciência e/ou dos distúrbios neurovegetativos.

  1. "Kevad uhkelt sammub mal kui jumalanna..." : [luuletused] / Ljubov Dergatshova ; tlk. Arvo Valton

    Index Scriptorium Estoniae

    Dergatshova, Ljubov

    2006-01-01

    Sisu: "Kevad uhkelt sammub mal kui jumalanna..." ; "Maga, pojake, maga mu päike..." ; "Mis kaunis õhtu! Lumi tahke..." ; "Raskel tunnil sirutab kes käe...". Luuletused paralleelselt ersa ja eesti keeles

  2. Diagnóstico tardio de malária em área endêmica de dengue na extra-Amazônia Brasileira: experiência recente de uma unidade sentinela no estado do Rio de Janeiro Delayed diagnosis of malaria in a dengue endemic area in the Brazilian extra-Amazon: recent experience of a malaria surveillance unit in state of Rio de Janeiro

    Directory of Open Access Journals (Sweden)

    Anielle de Pina Costa

    2010-10-01

    Full Text Available INTRODUÇÃO: A letalidade da malária na região extra-amazônica é cerca de 80 vezes maior do que na Amazônia, que concentra 99,8% dos casos do país. Em áreas de transmissão de dengue, como o Rio de Janeiro, o atraso no diagnóstico e tratamento da malária dos pacientes com febre, provenientes de áreas endêmicas de malária, pode ser, entre outros fatores, devido à confusão entre o diagnóstico das duas doenças pelos generalistas da rede de assistência médica. Neste trabalho, apresentamos as consequências do atraso diagnóstico em três pacientes com malária por Plasmodium falciparum; P. malariae e P. vivax, que, após o périplo habitual para tratamento de dengue, procuraram a nossa instituição onde foram corretamente diagnosticados e submetidos aos tratamentos adequados. MÉTODOS: Descrição de três casos de malária diagnosticada tardiamente e encaminhados ao IPEC/ FIOCRUZ, entre os anos de 2007 e 2008. RESULTADOS: uma brasileira proveniente de Moçambique, primo-infectada por P. falciparum, com malária diagnosticada após 6 dias do início da febre, morreu com malária cerebral e choque. Outro paciente com malária por P. malariae teve um curso grave e prolongado, mas ficou curado após o tratamento específico. A terceira paciente diagnosticada tardiamente apresentou malária por P. vivax adquirida na região de Mata Atlântica no Estado do Rio. CONCLUSÕES: Os profissionais de saúde do Rio devem ser treinados para aperfeiçoar a vigilância e o tratamento oportuno da malária e evitar desfechos mórbidos e fatais. Sugere-se que uma investigação de focos de malária autóctone em áreas de mata no estado seja realizada.INTRODUCTION: The mortality of malaria in the extra-Amazon region is about 80 times higher than in the Amazon region, where malaria is concentrated (99.8% of cases. In areas of dengue transmission, delay in the diagnosis and treatment of malaria in patients with fever who reside in areas of malaria

  3. BAYT AL-MAL AND ITS ROLE IN ECONOMIC DEVELOPMENT: A CONTEMPORARY STUDY

    Directory of Open Access Journals (Sweden)

    Md. Habibur RAHMAN

    2015-08-01

    Full Text Available Bayt al-Mal, known as the public treasury of Islamic state, was established by the Prophet-may peace be upon Him- and then it was further extended and expanded by Abu Bakr and Umar, who succeeded the Prophet as the Caliph of the Islamic state. It is the state treasury that keeps the sole authority to mobilize the funds of the state. This paper aims to study the potential role and contribution of Bayt al-Mal to economic development in the contemporary context. It will be a qualitative paper and the analytical and descriptive method will be applied. Historically Bayt al-Mal played a great role in the distribution and redistribution of funds. It performed the function that is similar to the function of the ministry of finance at present. It also carried out the jobs of central bank in terms of monitoring, issuing currencies, controlling credits and so forth. Through discussing its sources and expenditures the paper posits that the role of Bayt al-Mal can be revived and accelerated by, for example, providing small-medium funds, managing Zakah and awqaf, channeling the funds, issuing various financial instruments and so forth. Bayt al-Mal could have a significant role in the eradication of poverty from the state. The paper concludes that with the rapid growth of Islamic finance, the Bayt al-Mal can be utilized in parallel in order to have a robust economic development.

  4. Sobre a psicogênese do "mal de engasgo"

    Directory of Open Access Journals (Sweden)

    Durval Marcondes

    1947-06-01

    Full Text Available O A. ressalta o aspecto psicológico da etiologia do cardiospasmo ou mal de engasgo, assunto até agora não abordado nos meios científicos brasileiros. Sem pretender afastar outros elementos causais que tenham sido, porventura, verificados e que poderão, talvez, agir concomitantemente, o A. é de opinião que o mal de engasgo é um disturbio funcional condicionado psìquicamente, cujas conseqüências se tornam irreversíveis depois de certo tempo. As conclusões apresentadas baseiam-se no material fornecido por pacientes em tratamento psicanalítico que apresentam fenômenos disfágicos, e por vários casos das clínicas de orientação infantil entre cujos problemas se incluem, além da dificuldade de engulir, a anorexia e a bulimia. Com respeito às atividades emocionais típicas que formam o substrato psicológico do mal de engasgo, o ponto fundamental está em que êste representa um compromisso, expresso ao nível oral, entre tendências passivo-receptivas e ativo-expulsivas. A essa situação psíquica correspondem condições de ambiente, atuais ou pretéritas, que, de modo contraditório, favorecem uma atitude de dependência infantil, ao mesmo tempo que acarretam repetidas frustrações. Trata-se, em geral, de mães dominadoras que, enquanto superprotegem a criança, agem para com ela com demasiado rigor. A superproteção centraliza-se sobretudo no que se refere aos alimentos, que se investem, assim, de grande significado emocional. O A. apresenta o resumo de uma observação clínica que apoia seu ponto de vista. Também a anorexia e a bulimia, em seu substrato psicodinâmico, estão relacionadas com o problema do apego e da emancipação e giram em torno da pessoa da mãe e da função alimentar. A solução do conflito faz-se, porém, num dos casos, pela rejeição do alimento e, noutro, pela avidez. O mal de engasgo constitui o meio têrmo entre os dois extremos. Existem, igualmente, nas neuroses gástricas e em sua conseq

  5. Sobre el mal radical. Ensayo de la heterodoxia kantiana

    Directory of Open Access Journals (Sweden)

    Gómez Caffarena, José

    2004-06-01

    Full Text Available The kantian theory of a «radical evil inhabiting human nature» contrasts with a general anthropological optimistic tenor perceptible in kantian philosophy. It meant a significant turning point in the often too superficial optimistic trends of the Enlightenment. Hut its literal sense (appealing to an act of pre-individual freedom has an obvious difficulty. The present paper proposes an heterodox interpretation, which would avoid the difficulty, although so losing part of the tempting enigmatic reach of the kantian proposal.

    La teoría del «mal radical en la naturaleza humana», expuesta por Kant en La religión dentro de los límites de la mera razón, hace contraste con el optimismo antropológico que empapa el Criticismo. Constituyó, sin duda, una importante denuncia frente a la banalidad de muchos optimismos ilustrados. Pero su letra (acto de libertad pre-individual tiene una obvia dificultad. El artículo propone una reinterpretación que la evitaría, aunque desdramatizando un tanto el tentador alcance enigmático de la propuesta kantiana.

  6. Estudo histoquímico de proteínas fibrilares da matriz extracelular em neoplasias mamárias benignas e malignas na espécie canina

    Directory of Open Access Journals (Sweden)

    Ana Maria Cristina Rabello Pinto da Fonseca Martins

    2002-01-01

    Full Text Available A finalidade do presente trabalho foi estudar algumas das proteínas fibrilares da matriz extracelular de 54 neoplasias mamárias benignas e malignas na espécie canina, utilizando métodos histoquímicos: Picrosirius associado à polarização para fibras colágenas , método de Gordon - Sweats para fibras reticulares e método de Weigert com e sem oxidação para fibras elásticas. Evidenciou-se na matriz uma grande variabilidade na quantidade, distribuição e características dos componentes matriciais presentes nos diferentes tipos de neoplasias. Detectou-se, assim, colágeno I, III e elementos do sistema elástico, distribuídos diferentemente nas neoplasias benignas e malignas. O método Picrosirius simples e associado à polarização permitiu a visualização do colágeno sob a forma de fibras espessas distribuídas irregularmente no estroma dos carcinomas e de modo mais ordenado e regular nas neoplasias benignas e, fibras mais finas, em menor quantidade, irregularmente e aleatoriamente dispostas nos carcinomas e regularmente nas neoplasias benigna. Sob luz polarizada os feixes de fibras colágenas , apresentaram diferentes comprimentos, avermelhados ou amarelados e fortemente birrefringentes, sugerindo serem colágeno tipo I e, entremeando as fibras, algumas mais finas ,pálidas, esverdeadas e fracamente birrefringentes, presumivelmente colágeno tipo III. Em áreas condrometaplásicas, tanto nos carcinomas como nas neoplasias benignas notou-se que os feixes colágenos apresentavam-se com fibras finas, paralelas, limitando regiões estreitas onde os condrócitos se aninhavam, e, rodeando esta área, feixes de fibras espessas, anastomosadas, dispostas irregularmente nos carcinomas e ordenadamente e paralelas nas neoplasias benignas. Sob luz polarizada, essa população entre condrócitos era formada por fibras pálidas e amareladas, sugerindo padrão tipo II e na faixa circundante, feixes fortemente birrefringentes, sugerindo o padr

  7. Assessment of allelic diversity in intron-containing Mal d 1 genes and their association to apple allergenicity

    Directory of Open Access Journals (Sweden)

    Bolhaar Suzanne THP

    2008-11-01

    Full Text Available Abstract Background Mal d 1 is a major apple allergen causing food allergic symptoms of the oral allergy syndrome (OAS in birch-pollen sensitised patients. The Mal d 1 gene family is known to have at least 7 intron-containing and 11 intronless members that have been mapped in clusters on three linkage groups. In this study, the allelic diversity of the seven intron-containing Mal d 1 genes was assessed among a set of apple cultivars by sequencing or indirectly through pedigree genotyping. Protein variant constitutions were subsequently compared with Skin Prick Test (SPT responses to study the association of deduced protein variants with allergenicity in a set of 14 cultivars. Results From the seven intron-containing Mal d 1 genes investigated, Mal d 1.01 and Mal d 1.02 were highly conserved, as nine out of ten cultivars coded for the same protein variant, while only one cultivar coded for a second variant. Mal d 1.04, Mal d 1.05 and Mal d 1.06 A, B and C were more variable, coding for three to six different protein variants. Comparison of Mal d 1 allelic composition between the high-allergenic cultivar Golden Delicious and the low-allergenic cultivars Santana and Priscilla, which are linked in pedigree, showed an association between the protein variants coded by the Mal d 1.04 and -1.06A genes (both located on linkage group 16 with allergenicity. This association was confirmed in 10 other cultivars. In addition, Mal d 1.06A allele dosage effects associated with the degree of allergenicity based on prick to prick testing. Conversely, no associations were observed for the protein variants coded by the Mal d 1.01 (on linkage group 13, -1.02, -1.06B, -1.06C genes (all on linkage group 16, nor by the Mal d 1.05 gene (on linkage group 6. Conclusion Protein variant compositions of Mal d 1.04 and -1.06A and, in case of Mal d 1.06A, allele doses are associated with the differences in allergenicity among fourteen apple cultivars. This information

  8. A brief history of typical absence seizures - Petit mal revisited.

    Science.gov (United States)

    Brigo, Francesco; Trinka, Eugen; Lattanzi, Simona; Bragazzi, Nicola Luigi; Nardone, Raffaele; Martini, Mariano

    2018-03-01

    In this article, we have traced back the history of typical absence seizures, from their initial clinical description to the more recent nosological position. The first description of absence seizures was made by Poupart in 1705 and Tissot in 1770. In 1824, Calmeil introduced the term "absences", and in 1838, Esquirol for the first time used the term petit mal. Reynolds instead used the term "epilepsia mitior" (milder epilepsy) and provided a comprehensive description of absence seizures (1861). In 1854, Delasiauve ranked absences as the seizure type with lower severity and introduced the concept of idiopathic epilepsy. Otto Binswanger (1899) discussed the role of cortex in the pathophysiology of "abortive seizures", whereas William Gowers (1901) emphasized the importance of a detailed clinical history to identify nonmotor seizures or very mild motor phenomena which otherwise may go unnoticed or considered not epileptic. At the beginning of the 20th Century, the term pyknolepsy was introduced, but initially was not universally considered as a type of epilepsy; it was definitely recognized as an epileptic entity only in 1945, based on electroencephalogram (EEG) recordings. Hans Berger, the inventor of the EEG, made also the first EEG recording of an atypical absence (his results were published only in 1933), whereas the characteristic EEG pattern was reported by neurophysiologists of the Harvard Medical School in 1935. The discovery of EEG made it also possible to differentiate absence seizures from so called "psychomotor" seizures occurring in temporal lobe epilepsy. Penfield and Jasper (1938) considered absences as expression of "centrencephalic epilepsy". Typical absences seizures are now classified by the International League Against Epilepsy among generalized nonmotor (absence) seizures. Copyright © 2018 Elsevier Inc. All rights reserved.

  9. Metabolic and functional connectivity changes in mal de debarquement syndrome.

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    Yoon-Hee Cha

    Full Text Available Individuals with mal de debarquement syndrome (MdDS experience a chronic illusion of self-motion triggered by prolonged exposure to passive motion, such as from sea or air travel. The experience is one of rocking dizziness similar to when the individual was originally on the motion trigger such as a boat or airplane. MdDS represents a prolonged version of a normal phenomenon familiar to most individuals but which persists for months or years in others. It represents a natural example of the neuroplasticity of motion adaptation. However, the localization of where that motion adaptation occurs is unknown. Our goal was to localize metabolic and functional connectivity changes associated with persistent MdDS.Twenty subjects with MdDS lasting a median duration of 17.5 months were compared to 20 normal controls with (18F FDG PET and resting state fMRI. Resting state metabolism and functional connectivity were calculated using age, grey matter volume, and mood and anxiety scores as nuisance covariates.MdDS subjects showed increased metabolism in the left entorhinal cortex and amygdala (z>3.3. Areas of relative hypometabolism included the left superior medial gyrus, left middle frontal gyrus, right amygdala, right insula, and clusters in the left superior, middle, and inferior temporal gyri. MdDS subjects showed increased connectivity between the entorhinal cortex/amygdala cluster and posterior visual and vestibular processing areas including middle temporal gyrus, motion sensitive area MT/V5, superior parietal lobule, and primary visual cortex, while showing decreased connectivity to multiple prefrontal areas.These data show an association between resting state metabolic activity and functional connectivity between the entorhinal cortex and amygdala in a human disorder of abnormal motion perception. We propose a model for how these biological substrates can allow a limited period of motion exposure to lead to chronic perceptions of self-motion.

  10. Contribución al conocimiento de los malófagos (Phthiraptera, Amblycera, Ischnocera de aves peruanas. Parte 1

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    Luis A. Gomez-Puerta

    2015-12-01

    Full Text Available En el presente trabajo se reporta nueve especies de malófagos colectados de aves peruanas. Dos malófagos Amblycera: Heteromenopon laticapitis y Menacanthus pici, así como siete malófagos Ischnocera: Alcedoffula theresae, Brueelia brunneinucha, Chelopistes meleagridis, Columbicola columbae, Paragoniocotes aratingae, Penenirmus jungens y Saemundssonia (Saemundssonia lari, fueron determinados mediante el diagnóstico morfológico. Se realiza una breve descripción de cada malófago, así como la discusión de sus hospederos y distribución.

  11. Incidencia en España de la asbestosis y otras enfermedades pulmonares benignas debidas al amianto durante el período 1962-2010

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    Montserrat García Gómez

    2012-01-01

    Full Text Available Fundamentos: En España carecemos de una descripción completa de las enfermedades profesionales causadas por el amianto. El objetivo del presente trabajo esconocer la incidencia durante el período 1962-2010 de las asbestosis y otras enfermedades pulmonares benignas por amianto reconocidas como profesionales y su distribución por sectores, ocupación, sexo y ámbito geográfico. Métodos: El número de casos se obtuvo de las Memorias del INP (años 1962 a 1975, de la Estadística del Ministerio de Trabajo y las Memorias del Servicio de Higiene y Seguridad en el Trabajo (1976 a 1981 y de los Anuarios de Estadísticas Laborales a partir de 1982. Se obtuvieron tasas de incidencia específicas por actividad económica y ocupación. Se estudió la tendencia temporal del número de enfermedades a estudio, así como su distribución geográfica por Comunidad Autónoma y provincia. Resultados: Desde 1963 hasta 2010 se reconocieron 815 asbestosis y 46 afecciones fibrosantes de pleura y pericardio. La incidencia media anual de asbestosis fue 0,20 por 100.000 personas asalariadas (0,31 en el año 1990 y 0,40 en 2010. De 1990 a 2001 el sector del fibrocemento acumuló 189 casos de asbestosis, el naval 173, la construcción 49 y la metalurgia 35. Por ocupación, los operadores de maquinas fijas presentaron 114 casos, los moldeadores, soldadores, chapistas y montadores de estructuras metálicas 88 casos y los pintores, fontaneros e instaladores de tuberías 59. Las Comunidades Autónomas con más casos fueron la Valenciana (106, Galicia (86, Andalucía (82, Cataluña (75, Madrid (58 y País Vasco (41. Conclusiones: Las tasas de incidencia y la tendencia de asbestosis profesionales en España pueden estar evidenciando el infrareconocimiento del origen profesional de estas enfermedades en nuestro país. Los sectores más afectados fueron el del fibrocemento y el naval y la incidencia más alta se dió en la Comunidad Valenciana.

  12. Manobras de reposicionamento no tratamento da vertigem paroxística posicional benigna Treatment of benign paroxysmal positional vertigo with repositioning manevers

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    Roberto A. Maia

    2001-09-01

    Full Text Available Introdução: Vertigem paroxística posicional benigna (VPPB é uma das mais freqüentes patologias do sistema vestibular. Caracteriza-se clinicamente pela presença de episódios recorrentes de tonturas rotatórias, tipicamente desencadeados por determinados movimentos cefálicos, realizados pelo paciente. A confirmação diagnóstica é obtida exclusivamente pela manobra de Dix-Hallpike. Nessa manobra, observa-se sistematicamente o desencadeamento de nistagmo. Forma de estudo: Prospectivo clínico não randomizado. Material e método: No total, sete pacientes com diagnóstico clínico de VPPB são submetidos a tratamento pela manobra de reposicionamento de Epley. Resultado: Desses sete pacientes avaliados, cinco apresentaram ótima recuperação; dois, com resultado bom; e um, com mau resultado; para este último caso, outras formas de tratamento são apresentadas. Conclusão: O exame otoneurológico, realizado em todos os pacientes, demonstrou ser de interessante valor prognóstico quanto ao resultado do tratamento proposto. A manobra de reposicionamento de Epley demonstrou ser um método de tratamento da VPPB simples, e eficaz na grande maioria dos pacientes aqui relatados.Introduction: Benign Paroxysmal Positional Vertigo (BPPV is among the most common vestibular disorders. It is characterized by recurrent episodes of vertigo induced by changes in head position. The condition is readly diagnosed by performing the Dix-Hallpike maneuver. Nystagmus is always present by this way. Study design: Prospective results clinical not randomized. Material and method: A total of seven patients diagnosed with BPPV received the repositioning maneuver of Epley. Five out of seven patients had excellent recovery, two patients had good results and one had a bad result. For this last one different treatments are discussed. Conclusion: We performed otoneurological examination in all patients; this test seems to be an intersting prognosis method for seeking the

  13. Interaction of PLP with GFP-MAL2 in the human oligodendroglial cell line HOG.

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    Raquel Bello-Morales

    Full Text Available The velocity of the nerve impulse conduction of vertebrates relies on the myelin sheath, an electrically insulating layer that surrounds axons in both the central and peripheral nervous systems, enabling saltatory conduction of the action potential. Oligodendrocytes are the myelin-producing glial cells in the central nervous system. A deeper understanding of the molecular basis of myelination and, specifically, of the transport of myelin proteins, will contribute to the search of the aetiology of many dysmyelinating and demyelinating diseases, including multiple sclerosis. Recent investigations suggest that proteolipid protein (PLP, the major myelin protein, could reach myelin sheath by an indirect transport pathway, that is, a transcytotic route via the plasma membrane of the cell body. If PLP transport relies on a transcytotic process, it is reasonable to consider that this myelin protein could be associated with MAL2, a raft protein essential for transcytosis. In this study, carried out with the human oligodendrocytic cell line HOG, we show that PLP colocalized with green fluorescent protein (GFP-MAL2 after internalization from the plasma membrane. In addition, both immunoprecipitation and immunofluorescence assays, indicated the existence of an interaction between GFP-MAL2 and PLP. Finally, ultrastructural studies demonstrated colocalization of GFP-MAL2 and PLP in vesicles and tubulovesicular structures. Taken together, these results prove for the first time the interaction of PLP and MAL2 in oligodendrocytic cells, supporting the transcytotic model of PLP transport previously suggested.

  14. Maltase protein of Ogataea (Hansenula) polymorpha is a counterpart to resurrected ancestor protein ancMALS of yeast maltases and isomaltases

    DEFF Research Database (Denmark)

    Viigand, Katrin; Visnapuu, Triinu; Mardo, Karin

    2016-01-01

    and mutation of the genes. We studied substrate specificity of the maltase protein MAL1 from an earlier diverged yeast, Ogataea polymorpha (Op), in the light of this hypothesis. MAL1 has extended substrate specificity and its properties are strikingly similar to those of resurrected ancMALS. Moreover, amino......, indicating the power of the method to predict substrate binding. Deletion of either the maltase (MAL1) or α-glucoside permease (MAL2) gene in Op abolished the growth of yeast on MAL1 substrates, confirming the requirement of both proteins for usage of these sugars....

  15. Estudio retrospectivo de masas cutáneas neoplásicas en caninos diagnosticadas histopatológicamente en la Universidad de La Salle (1999-2003

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    Carlos Eduardo Aparicio Ortiz

    2008-12-01

    Full Text Available El propósito del trabajo fue realizar un análisis retrospectivo de las neoplasias cutáneas en caninos diagnosticadas en la Universidad de La Salle, en Bogotá, en el período 1999-2003. El presente estudio se llevó a cabo con la información obtenida de los registros del área diagnóstica e histopatológica de la Universidad de La Salle. La información fue discriminada y analizada teniendo en cuenta las siguientes variables: diagnóstico, raza, sexo, edad, malignidad y localización del tumor. Los 192 casos de pacientes abordados en el estudio fueron agrupados de acuerdo con las neoplasias con el fin de determinar las características y el comportamiento de dichas patologías. La edad promedio de los pacientes fue de 6,5 años, la raza más afectada el Bóxer con el 19,1% (32 perros, seguido del Labrador con un 13% (26 perros y el Caniche con un 10,5% (22 perros; los pacientes machos fueron los más afectados con un 58% (107 perros. Se reveló la gran incidencia del tumor de células de mast (26,2% en el 2003 y 20% en el 2002 y el histiocitoma (12,3% en el 2003 y 10% en el año 2002. Entre otras neoplasias que se observaron de forma recurrente en el estudio se destacan el lipoma, tricoepitelioma, carcinoma de células escamosas y papilomatosis.

  16. Social, societal, and economic burden of mal de debarquement syndrome.

    Science.gov (United States)

    Macke, Allison; LePorte, Andrew; Clark, Brian C

    2012-07-01

    Mal de debarquement syndrome (MdDS) is a disorder of phantom perception of self-motion of unknown cause. The purpose of this work was to describe the quality of life (QOL) of patients with MdDS and to estimate the economic costs associated with this disorder. A modified version of a QOL survey used for another neurological disease (multiple sclerosis; MSQOL-54) was used to assess the impact of MdDS on QOL in 101 patients. The estimated economic costs were based on self-reported direct and indirect costs of individuals living in the United States using Medicare reimbursement payment rates for 2011 in 79 patients. Patients with MdDS reported a poor overall QOL as indicated by a mean composite QOL score of 59.26 ± 1.89 (out of 100). The subcategories having the lowest QOL rating were role limitations due to physical problems (18.32 ± 3.20), energy (34.24 ± 1.47), and emotional problems (36.30 ± 4.00). The overall physical health composite score including balance was 49.40 ± 1.69, and the overall mental health composite score was 52.40 ± 1.83. The cost to obtain a diagnosis was $2,997 ± 337, which included requiring an average of 19 physician visits per patient. The direct cost of MdDS medical care was $826 ± 140 per patient per year, which mainly included diagnostic imaging and physician visits. The indirect costs (i.e., lost wages) were $9,781 ± 2,347 per patient per year. Among 65 patients who were gainfully employed when they acquired MdDS, the indirect costs were $11,888 ± 2,786 per patient per year. Thus, the total annual cost of the disorder ranged from $11,493 ± 2,341 to $13,561 ± 2,778 per patient per year depending on employment status prior to developing MdDS. MdDS negatively and dramatically impacts QOL, and also imposes a substantial economic burden on MdDS patients. These findings underscore the need for further basic and clinical research on MdDS.

  17. Minilaparoscopic-assisted transvaginal approach in benign liver lesions Abordaje transvaginal asistido por minilaparoscopia en lesiones benignas del hígado

    Directory of Open Access Journals (Sweden)

    R. Castro-Pérez

    2010-06-01

    benignas del hígado tratadas quirúrgicamente mediante el abordaje transvaginal asistido por minilaparoscopia. Pacientes y métodos: mujeres de 44 y 45 años de edad, respectivamente. La paciente 1 presentaba un pequeño tumor de 1,2 cm de Ø, en el lóbulo izquierdo del hígado. En su preoperatorio no se logró precisar su etiología y se decidió extirparlo quirúrgicamente. La paciente 2 presentaba un quiste simple del hígado muy sintomático de 8 cm de Ø situado en el subsegmento VI, se negó a realizarse el tratamiento esclerosante por vía percutánea, por lo que se recomendó el tratamiento quirúrgico. Se les ofreció a ambas realizar la intervención mediante cirugía laparoscópica o el abordaje transvaginal, aceptando este último. El neumoperitoneo se realizó con presión de 15 mmHg. Se colocaron 2 minipuertos en abdomen, uno en región umbilical de 5 mm Ø y el otro de 3 mm Ø en el sitio más próximo a la lesión. Con visión directa se colocó 1 trocar en la pared posterior del fondo del saco vaginal de 11 mm Ø para el paso de un endoscopio rígido. En la paciente 1 se utilizó este mismo orificio para, adyacente al trocar, introducir un disector largo. En la paciente 2 se introdujo un segundo trocar de 5 mm Ø para el paso de instrumentos de trabajo. Ambos especímenes fueron extraídos a través de la vagina en bolsas extractoras. Se registró el tiempo quirúrgico, necesidad de analgésicos y complicaciones postoperatorias. Resultados: los tiempos quirúrgicos fueron de 51 y 73 minutos, respectivamente. La paciente operada del quiste hepático requirió administración de analgésico postoperatorio. El alta hospitalaria fue dada antes de las 24 horas de la intervención. No se han presentado complicaciones postoperatorias relacionadas con el proceder después de un seguimiento mínimo de 6 meses. Conclusiones: con el empleo de instrumentos rígidos, fue posible realizar el tratamiento quirúrgico de dos lesiones benignas del hígado, de poca

  18. Estado de mal epiléptico en pediatría

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    Jorge Malagón Valdez

    2013-09-01

    Full Text Available El estado de mal epiléptico es una emergencia médica en la cual se presentan crisis epilépticas por 30 minutos o más de actividad continua, o bien dos o más crisis consecutivas sin recuperación completa de la conciencia entre las mismas. Actualmente se considera que una crisis epiléptica convulsiva o no, que dure más de 5 minuto se deberá considerar un estado de mal epiléptico. Se han utilizado diversos fármacos para el tratamiento de esta patología y sus secuelas. Hay un consenso generalizado en que se debe realizar un manejo agresivo para disminuir su morbi-mortalidad, sin olvidarse que la causa del estado de mal es importante para su manejo, control y sus secuelas.

  19. La seducción del mal en Estrella Distante de Roberto Bolaño

    OpenAIRE

    Montes, Cristian

    2013-01-01

    En el presente artículo se trabajará en torno a la novela Estrella distante de Roberto Bolaño. La intención del análisis será demostrar cómo se expresa y opera la seducción del mal al interior de la representación y proponer cuáles son las formas en que el mal encarna en una figura representativa de la dictadura militar chilena.

  20. Esporotricosis diagnosticada por el laboratorio

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    Nelly Ordóñez

    1989-06-01

    Full Text Available De 1976 a 1989 se han diagnosticado 40 casos de esporotricosis en el laboratorio de Micología del Instituto Nacional de Salud. La enfermedad se presentó en pacientes entre 4 y 52 años y tuvo predilección por el sexo masculino: 35 de 40 (87,5%; las formas clínicas más frecuentes fueron la cutánea fija, 18 de 40 (45%, y la linfocutánea, 17 de 40 (42,5%, con localización mayor en miembros superiores, 18 de 40 (45%. El diagnóstico se estableció por el aislamiento del Sporothrix schenckii en 35 de 38 pacientes (92%; los otros dos pacientes se diagnosticaron empleando otras técnicas: inmunofluorescencia directa, intradermorreacción y aglutinación en tubo.

  1. Rising Mal-Employment and the Great Recession: The Growing Disconnection between Recent College Graduates and the College Labor Market

    Science.gov (United States)

    Fogg, Neeta P.; Harrington, Paul E.

    2011-01-01

    This article looks at the phenomenon of mal-employment among college graduates in the United States, beginning with an overview of labor-market trends and the effects of the Great Recession on the job-market experiences of young people, including recent college graduates. It then defines "mal-employment" and examines its incidence over…

  2. Maturity and storage influence on the apple (Malus domestica) allergen Mal d 3, a nonspecific lipid transfer protein

    NARCIS (Netherlands)

    Sancho, Ana I.; Foxall, Robert; Rigby, Neil M.; Browne, Thomas; Zuidmeer, Laurian; van Ree, Ronald; Waldron, Keith W.; Mills, E. N. Clare

    2006-01-01

    Consumption of apples can provoke severe allergic reactions, in susceptible individuals, due to the presence of the allergen Mal d 3, a nonspecific lipid transfer protein, found largely in the fruit skin. Levels of Mal d 3 were determined in peel as a function of apple cultivar, position of the

  3. Le mal de Pott: à propos de 82 cas

    Directory of Open Access Journals (Sweden)

    Badr Fedoul

    2011-03-01

    Full Text Available Nous rapportant dans cette étude, les résultats de l’expérience du service de neurochirurgie du CHU Hassan II de Fès dans la prise en charge du mal de pott dans la région de Fès. Il s’agit d’une étude rétrospective de quatre-vingt-deux cas; étalée sur une période de cinq ans (janvier 2002 au décembre 2006. L’objectif de ce travail était d’illustrer les différents aspects épidémiologiques, diagnostiques et thérapeutiques de la localisation vertébrale de la tuberculose dans notre pratique. L'âge moyen de nos patients était de 43,1 ans, avec une légère prédominance féminine (53,82%. La durée d'évolution de la maladie était longue (dix mois en moyenne; ceci est expliquée par la symptomatologie initiale insidieuse faite de rachialgies (98,78% et une admission des patients au stade de complications neurologiques (41,46%. La radiographie standard était réalisée chez tous nos patients, et complétée par la TDM dans 86.58% des cas ce qui a permis de déceler la prédominance de l'atteinte dorsale et lombaire. L'IRM est l'examen de choix, elle était demandée chez tous les malades déficitaires (37,8%.Tous nos patients ont bénéficié d'un traitement antibacillaire associé à une immobilisation du foyer pottique. Une décompression par voie antérieure était réalisée chez 29 patients (35,36 %; alors que la laminectomie n'était pratiquée que chez 5 patients (6.09 %, tandis que l'évacuation de l'abcès de psoas était réalisée chez 25 patients (30,48 %. Le diagnostic de certitude histologique était posé dans 51 cas (62,19%. Les meilleurs résultats étaient obtenus chez les malades opérés par voie antérieure, 26 cas (89,65% de récupération totale et 3 cas (10,34% partielle. L'évolution vers la consolidation et la fusion vertébrale était la règle chez tous nos malades et ceci au bout de 4 à 18 mois après le traitement.

  4. Pengaruh Unsur Alam terhadap Minat Berkunjung Kembali di Mal

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    Riza Septriani Dewi

    2016-12-01

    Full Text Available Pusat perbelanjaan yang berkonsep alam dianggap lebih diminati pengunjung. Penelitian ini mengkaji tentang pengaruh unsur-unsur alam terhadap minat konsumen untuk berkunjung kembali. Variabel yang akan dikaji terdiri dari variabel bebas, yaitu air (diam-bergerak dan vegetasi (tanaman rendah-tanaman tinggi, dan variabel terikat, yaitu persepsi alam dan sikap berkunjung kembali. Penelitian ini menggunakan metode eksperimen stimulus-respon melalui pendekatan kuantitatif dengan prinsip between-subject factorial design. Simulasi gambar digital dari interior pusat perbelanjaan pada 4 kondisi sebagai kombinasi variabel tersebut di atas digunakan sebagai stimulus percobaan, di mana 4 kelompok responden, masing-masing 20 orang, akan menilai stimulus eksperimen dalam kondisi berbeda, atas dasar persepsi alam dan sikap berkunjung kembali. Data eksperimen dihitung dan dianalisa dengan statistik one-way ANOVA. Efek kombinasi variabel air bergerak dan tanaman tinggi ternyata tidak memberikan pengaruh yang signifikan terhadap persepsi alam responden. Efek kombinasi variabel air diam dengan tanaman tinggi tidak memberikan pengaruh yang signifikan terhadap minat responden untuk berkunjung kembali. Namun, efek kombinasi variabel air mengalir dengan tanaman rendah cenderung lebih mengundang persepsi alam yang baik dan minat berkunjung kembali. Hasil eksperimen ini diharapkan dapat menjadi rekomendasi bagi perkembangan ilmu desain dan sebagai salah satu referensi bagi desainer dan pengembang.Kata Kunci: mal; minat berkunjung; persepsi alam; perilaku konsumen.Effects of Natural Elements on Interest to Revisit a MallShopping malls with a natural concept are more attractive to visitors. This study examined the influence of natural interior design elements on client interest to revisit a mall. The assessed elements consisted of independent variables, namely water (still-standing/flowing and vegetation (ground plants/potted plants, and dependent variables, namely nature

  5. Tratamento conservador das estenoses benignas do esôfago através de dilatações. Análise de 500 casos

    Directory of Open Access Journals (Sweden)

    ANDREOLLO N.A.

    2001-01-01

    Full Text Available As estenoses benignas do esôfago (EBE são complicações muito freqüentes, resultado de várias etiologias, a saber: refluxo gastro-esofágico, ingestão de agentes corrosivos, pós-cirurgias do esôfago, pós-radioterapia no tórax, pós-escleroterapia endoscópica de varizes do esôfago, ingestão de medicamentos, uso prolongado de cateter nasogástrico, compressão extrínseca e membranas esofágicas congênitas. As dilatações esofágicas são recomendadas no tratamento dessa complicação, empregando dilatadores de vários tipos e diâmetros, facilitando ao doente a ingestão alimentar. OBJETIVOS: Avaliação dos resultados e vantagens do tratamento conservador das EBE através de dilatações esofágicas realizadas ambulatorialmente com auxílio da endoscopia digestiva flexível. MÉTODOS: No período de 1981 a 1999 foram tratados, conservadoramente e seguidos no Gastrocentro -- UNICAMP, 500 doentes com EBE, através de um Programa de Dilatações Esofágicas instituído para cada caso. A maioria era do sexo masculino (59,2% e a faixa etária mais acometida encontra-se entre 31 anos e 60 anos, compreendendo 52,8% dos pacientes em estudo. As estenoses mais prevalentes foram as estenoses pépticas (30,4%, cáusticas (23,6%, de anastomoses (23,2%, por megaesôfago (8,0% e por uso prolongado de cateter nasogástrico (6,4%, perfazendo um total de 91,6% das EBE. Quanto ao número de procedimentos, 94,2% dos casos foram submetidos a no máximo 25 dilatações do esôfago. Em 95,6% deles foram utilizados dilatadores com diâmetro entre 10,5 mm e 16,0 mm. A duração do tratamento foi até 24 meses em 76,2% dos casos. Perfurações esofágicas ocorreram em seis doentes (1,2%, sem mortalidade. RESULTADOS: Foram considerados bons em 76,2%, regulares em 18,2% e maus em 5,6% dos doentes. O sucesso do tratamento variou conforme a etiologia da estenose, ocorrendo bons resultados em 81,0% das estenoses pépticas, em 66,1% das estenoses cáusticas e em

  6. Valoración clínica, psicológica y de laboratorio a niños con hiperfenilalaninemia benigna al nacimiento

    Directory of Open Access Journals (Sweden)

    Enna Gutiérrez García

    2002-12-01

    Full Text Available Las hiperfenilalaninemias, alteraciones en el metabolismo de la fenilalanina, poseen heterogeneidad genética, clínica y bioquímica, con fenilalanina en plasma, mayor de 120 µmol/L (2 mg/dL. La benigna tiene valores entre 240 y 600 µmol/L (4 a 10 mg/dL con mayor actividad enzimática y no requiere tratamiento dietético. Se realizó una valoración clínica y de laboratorio a 32 niños con esta alteración al nacimiento entre 1989 y 1999, para conocer variaciones en las concentraciones séricas en el tiempo, presentación de algún síntoma o signo clínico de la enfermedad y el coeficiente de inteligencia de estos. Los 32 niños estudiados presentaron disminución de niveles del aminoácido, con respecto al nacimiento, entre 90 y 287 µmol/L (1, 5 mg/dL a 5, 52 mg/dL. La mayoría no mostró síntomas o signos clínicos de fenilcetonuria. El coeficiente de inteligencia promedio fue de 100,6 puntos. Se recomienda el estudio a todos los niños con esta alteración en Cuba y realizar estudios de mutaciones para demostrar la heterogeneidad alélica que explicara la expresividad variable en el fenotipo bioquímico y clínico en estos niños.Hyperphenylalaninemias, which are disorders in the metabolism of phenylalanine, show genetic, clinical and biochemical heterogeneity, with phenylalanine in plasma over 120 µmol/L (2 mg/dL. Benign hyperphenylalaninemia has values from 240 to 600 µmol/L (4 a 10 mg/dL with higher enzymatic activity and does not require diet therapy. A clinical and lab assessment of 32 children with this disorder at birth was made from 1989 to 1999 to find out the variations in time of serum concentrations, occurrence of some clinical symptom or sign of the disease and their intelligence quotient. The 32 studied children presented with reduction of aminoacid levels of 90 to 287 µmol/L (1, 5 mg/dL a 5, 52 mg/dL with respect to birth levels. The majority did not show clinical symptoms or signs of phenylketonuria. Average

  7. Malformações do sistema nervoso central e malformações associadas diagnosticadas pela ultrassonografia obstétrica

    Directory of Open Access Journals (Sweden)

    Marcela Leonardo Barros

    2012-12-01

    Full Text Available OBJETIVO: Identificar a prevalência de malformações congênitas do sistema nervoso central (SNC e malformações associadas diagnosticadas pela ultrassonografia obstétrica. MATERIAIS E MÉTODOS: Estudo observacional, transversal, descritivo, em instituição de referência para gestações de alto risco. RESULTADOS: Malformações congênitas do SNC estiveram presentes sem outras malformações associadas em 65,78%, com a distribuição: hidrocefalia (37,5%, mielomeningocele (15%, encefalocele (12,5%, agenesia de corpo caloso (12,5%, anencefalia (12,5%, holoprosencefalia (7,5%, Dandy-Walker (7,5%, Arnold-Chiari (5,0%, hidranencefalia (5,0%, meningocele (5,0%, cisto aracnoideo (2,5%. Malformações congênitas de outros sistemas estiveram associadas às do SNC: craniofacial (73,9%, ortopédica (65,2%, cardiovascular (34,8%, geniturinária (30,4%, gastrintestinal (30,4%, respiratória (8,7%, sindrômica (8,7, oftalmológica (4,3%. A sensibilidade ultrassonográfica no estudo de malformações fetais do SNC foi 79,4%. A taxa de falso-negativos foi 20,5%. Dentre as limitações quantificáveis destaca-se o oligodrâmnio, presente em 25% dos falso-negativos. CONCLUSÃO: A ultrassonografia obstétrica possui boa sensibilidade no rastreio de malformações fetais do SNC, em especial com o aperfeiçoamento constante e domínio na utilização de métodos especializados, como o Doppler e a ultrassonografia volumétrica (3D/4D, contribuindo para firmar-se como modalidade de escolha nesta rotina. Complementar ao método, a ressonância magnética pode vir a fornecer subsídios para uma ainda melhor assistência perinatal.

  8. MAL Is a Regulator of the Recruitment of Myelin Protein PLP to Membrane Microdomains

    NARCIS (Netherlands)

    Bijlard, Marjolein; de Jonge, Jenny C.; Klunder, Bert; Nomden, Anita; Hoekstra, Dick; Baron, Wia

    2016-01-01

    In oligodendrocytes (OLGs), an indirect, transcytotic pathway is mediating transport of de novo synthesized PLP, a major myelin specific protein, from the apical-like plasma membrane to the specialized basolateral-like myelin membrane to prevent its premature compaction. MAL is a well-known

  9. Synthesis, crystal structure and magnetic properties of [Cu(mal)(abpt ...

    African Journals Online (AJOL)

    Complex 1 consist of a neutral mononuclear [Cu(mal)(abpt)(H2O)] unit and water molecule of crystallization in a distorted square pyramidal coordination sphere, while complex 2 is viewed as being made up of [Cu(sq)(abpt)2] units with the squarato ligand bridging the two copper(II) cations. Variable temperature magnetic ...

  10. Preparation of MAl O : Eu2+, Sm3+ (M = Ca, Sr, Ba) Phosphors by ...

    African Journals Online (AJOL)

    NJD

    2007-10-15

    Oct 15, 2007 ... clearly show that most peaks are assigned to those of the MAl2O4 structure. Moreover, their structures change with change of M. Samples A and B exhibit monoclinic crystal systems and sample. C a hexagonal structure. The doping Eu2+ and co-doping Sm3+ have very little influence on the structure of the ...

  11. Mal de Meleda: A Report of Two Cases In One Family

    Directory of Open Access Journals (Sweden)

    M.Kantor

    2006-08-01

    Full Text Available Mal de Meleda is a rare autosomal recessive skin disorder, characterized by transgressive palmoplantar keratoderma, lichenoid skin lesions, perioral erythema, brachydactyly and nail abnormalities. We are reporting two cases of a clinically typical disease in a family. No consanguineous relationship between the parents was known and cases could not be detected in three generations of the patient's family.

  12. Preparation of MAl 2 O 4 : Eu 2+ , Sm 3+ (M = Ca, Sr, Ba) Phosphors ...

    African Journals Online (AJOL)

    A series of MAl2O4: Eu2+, Sm3+ (M = Ca, Sr, Ba) phosphors was prepared by the combustion method, and the influence of these alkaline earth metals on the structure and luminescent performances for these phosphors was investigated. A relationship was established between their composition, crystallization capacity and ...

  13. High temperature increases the masculinization rate of the all-female (XX) rainbow trout "Mal" population.

    Science.gov (United States)

    Valdivia, Karina; Jouanno, Elodie; Volff, Jean-Nicolas; Galiana-Arnoux, Delphine; Guyomard, René; Helary, Louise; Mourot, Brigitte; Fostier, Alexis; Quillet, Edwige; Guiguen, Yann

    2014-01-01

    Salmonids are generally considered to have a robust genetic sex determination system with a simple male heterogamety (XX/XY). However, spontaneous masculinization of XX females has been found in a rainbow trout population of gynogenetic doubled haploid individuals. The analysis of this masculinization phenotype transmission supported the hypothesis of the involvement of a recessive mutation (termed mal). As temperature effect on sex differentiation has been reported in some salmonid species, in this study we investigated in detail the potential implication of temperature on masculinization in this XX mal-carrying population. Seven families issued from XX mal-carrying parents were exposed from the time of hatching to different rearing water temperatures ((8, 12 and 18°C), and the resulting sex-ratios were confirmed by histological analysis of both gonads. Our results demonstrate that masculinization rates are strongly increased (up to nearly two fold) at the highest temperature treatment (18°C). Interestingly, we also found clear differences between temperatures on the masculinization of the left versus the right gonads with the right gonad consistently more often masculinized than the left one at lower temperatures (8 and 12°C). However, the masculinization rate is also strongly dependent on the genetic background of the XX mal-carrying families. Thus, masculinization in XX mal-carrying rainbow trout is potentially triggered by an interaction between the temperature treatment and a complex genetic background potentially involving some part of the genetic sex differentiation regulatory cascade along with some minor sex-influencing loci. These results indicate that despite its rather strict genetic sex determinism system, rainbow trout sex differentiation can be modulated by temperature, as described in many other fish species.

  14. Estudo exploratório da utilização de saw palmetto no tratamento da hiperplasia benigna da próstata por urologistas de Porto Alegre

    Directory of Open Access Journals (Sweden)

    Gabriela Ferreira

    Full Text Available O objetivo deste trabalho foi avaliar a utilização de fitoterápicos a base de saw palmetto na terapia sintomática da hiperplasia benigna da próstata (HBP por médicos urologistas da cidade de Porto Alegre. Consistiu em um estudo transversal, exploratório, por meio de entrevista semi-estruturada aplicada a urologistas de Porto Alegre. A amostra foi obtida utilizando catálogo do plano de saúde UNIMED- Porto Alegre. A randomização foi realizada através de sistemática aleatória, sendo sorteados trinta e cinco médicos, dos quais 21 foram selecionados para realização da pesquisa através de questionário. Todos os urologistas entrevistados avaliam e tratam pacientes com hiperplasia benigna da próstata. O saw palmetto não foi citado como terapia medicamentosa de 1ª ou 2ª escolhas no tratamento da HBP. O grupo farmacológico mais freqüentemente utilizado para o tratamento da HBP foi ∝-bloqueadores. Mais da metade dos médicos entrevistados relata ter conhecimento sobre a utilização do saw palmetto, principalmente através de artigos científicos. Os resultados indicam que o saw palmetto não é prescrito pelos urologistas em Porto Alegre, todavia a maior parte destes profissionais tem conhecimento sobre sua utilização.

  15. Dermatomiosite recém-diagnosticada em idosos como preditiva de malignidade Newly diagnosed dermatomyositis in the elderly as predictor of malignancy

    Directory of Open Access Journals (Sweden)

    Fernando Henrique Carlos de Souza

    2012-10-01

    Full Text Available OBJETIVO: Os sintomas da dermatomiosite (DM podem ser um indício da existência de um câncer oculto. Melhorar a detecção precoce é essencial, porém não há estudos avaliando em curto prazo os fatores preditivos para a doença. MÉTODO: Estudo retrospectivo, monocêntrico, incluindo pacientes com DM definida (pelo menos quatro dos cinco critérios de Bohan e Peter, 1975, no período entre 1991 e 2011. A presença de malignidade foi limitada a um período de até 12 meses após o diagnóstico da doença. RESULTADOS: Houve 12 casos de neoplasias em 139 pacientes (pele, trato gastrintestinal, próstata, tireoide, mama, pulmão e trato geniturinário. Os pacientes com neoplasia tiveram maior média de idade que os controles (56,8 ± 15,7 vs. 40,3 ± 13,1 anos, respectivamente, P = 0,004; odds ratio 1,09; intervalo de confiança de 95%: 1,04-1,14. Não foram observadas diferenças estatísticas em relação a gênero, etnia, frequência de sintomas constitucionais, envolvimento de órgãos e sistemas e/ou alterações laboratoriais. CONCLUSÃO: Na DM recém-diagnosticada, a idade tardia ao diagnóstico foi um fator preditivo de malignidade.OBJECTIVE: Dermatomyositis (DM symptoms may be a clue to the existence of a hidden cancer. Enhancing early detection is essential, but there are no studies evaluating short-term predictive factors in this disease. METHODS: This is a singlecenter retrospective study, including patients diagnosed with DM meeting at least four of the five Bohan and Peter's criteria (1975, from 1991 to 2011. This study assessed malignancies occurring in up to 12 months after the diagnosis of DM. RESULTS: Neoplasm was found in 12 out of 139 patients (skin, gastrointestinal tract, prostate, thyroid, breast, lungs, and genitourinary tract. Patients with neoplasm had a higher mean age than controls (56.8 ± 15.7 vs. 40.3 ± 13.1 years, respectively, P = 0.004, odds ratio 1.09; 95% confidence interval: 1.04-1.14. No statistical

  16. Disparities in undiagnosed diabetes among United States-Mexico border populations Disparidades en la prevalencia de diabetes no diagnosticada en las poblaciones residentes en la frontera México-Estados Unidos

    Directory of Open Access Journals (Sweden)

    Pamela Stoddard

    2010-09-01

    Full Text Available OBJECTIVE: To compare the prevalence of undiagnosed diabetes among populations with diabetes living on the United States (U.S.-Mexico border, examine explanations for differences between groups, and investigate differences in metabolic outcomes by diagnosis status. METHODS: Data come from the U.S.-Mexico Border Diabetes Prevention and Control Project survey (2001-2002, which used a stratified, multistage design. The sample included 603 adults (18 years or older with diabetes. Undiagnosed diabetes was defined as a fasting plasma glucose (FPG value of > 126 mg/dL and no report of diagnosis. Logistic regression was used to compare the odds of being undiagnosed among border populations with diabetes. Metabolic outcomes included FPG, glycosylated hemoglobin, and mean arterial blood pressure. RESULTS: One in four adults with diabetes (25.9% living on the U.S.-Mexico border was undiagnosed. Mexicans (43.8% and Mexican immigrants (39.0% with diabetes were significantly more likely to be undiagnosed than were U.S.-born Hispanics (15.0%; P OBJETIVO: Comparar la prevalencia de diabetes no diagnosticada en la población con diabetes residente en la zona fronteriza entre México y los Estados Unidos; intentar explicar las diferencias entre grupos, e investigar las diferencias de los resultados metabólicos según la situación diagnóstica. MÉTODOS: Los datos proceden de la encuesta del Proyecto de Prevención y Control de la Diabetes en la Frontera México-Estados Unidos (2001-2002, que utilizó un diseño estratificado polietápico. La muestra incluyó a 603 adultos (> 18 años con diabetes. Se definió como diabetes no diagnosticada una glucemia plasmática en ayunas > 126 mg/dl sin diagnóstico previo. Se utilizó un modelo de regresión logística para comparar la probabilidad de que la diabetes no fuera diagnosticada en las poblaciones fronterizas. Los resultados metabólicos incluyeron la glucemia plasmática en ayunas, la hemoglobina glicosilada (Hb

  17. [Eugen Helimski, Urlike Kahrs. Nordselkupisches Wörterbuch von F. G. Mal'cev (1903)] / Ago Künnap

    Index Scriptorium Estoniae

    Künnap, Ago, 1941-

    2003-01-01

    Raamatust: Helimski, Eugen, Kahrs, Urlike. Nordselkupisches Wörterbuch von F. G. Mal'cev (1903). Hamburg, 2001. (Hamburger Sibirische und Finnisch-Ugrische Materialen / Habent Sua Fata Manuscripts; 1)

  18. La Seducción del mal en estrella distante de Roberto Bolaño

    OpenAIRE

    Montes, Cristian

    2013-01-01

    En el presente artículo se trabajará en torno a la novela Estrella distante de Roberto Bolaño. La intención del análisis será demostrar cómo se expresa y opera la seducción del mal al interior de la representación y proponer cuáles son las formas en que el mal encarna en una figura representativa de la dictadura militar chilena. This article is based on the Roberto Bolaño novel Estrella Distante. The analysis aims to demonstrate the ways that the seduction of evil is expressed and operates...

  19. Une localisation exceptionnelle de la tuberculose vertébrale Mal de Pott sous-occipital

    Science.gov (United States)

    Yahyaoui, Sana; Majdoub, Senda; Zaghouani, Houneida; Fradj, Hosni Ben; Bakir, Dejla; Bouajina, Elyes; Kraiem, Chakib

    2013-01-01

    Le mal de Pott est la forme la plus commune de la tuberculose osseuse touchant essentiellement le rachis dorso-lombaire. La localisation sous-occipitale reste exceptionnelle. Le diagnostic de cette entité est le plus souvent tardif ce qui expose à des complications graves. Les radiographies standard ne sont parlantes qu’à un stade tardif de la maladie, d'où l'intérêt de l'imagerie moderne notamment la tomodensitométrie (TDM) et l'imagerie par résonance magnétique (IRM) qui permettent un diagnostic précoce. Nous rapportons un nouveau cas de tuberculose sous-occipitale. Le diagnostic était posé sur l'imagerie en coupe et confirmé histologiquement à la biopsie transorale. Sont rappelés les aspects en imagerie de cette localisation particulière du mal de Pott. PMID:23819005

  20. Rotational Mal-Alignment after Reamed Intramedullary Nailing for tibial shaft fracture.

    Science.gov (United States)

    Khan, Sher Baz; Mohib, Yasir; Rashid, Rizwan Haroon; Rashid, Haroonur

    2016-10-01

    Intra-medullary (IM) nailing is standard of care for unstable tibial shaft fractures. Malrotation is very common but it is under-recognised, inpart because of variation in normal anatomy and partly due to difficulty in accurately assessing rotation. This study was planned to evaluate the frequency of rotational mal-alignment after reamed tibia IMnailing. This cross-sectional study was conducted at Aga khan University Hospital, Karachi, and comprised patients with tibia shaft fractures managed with IMnailing from January to December 2014. All the patients were assessed intra-operatively for rotational alignment using the knee and ankle fluoroscopic images. There were 81 patients with a mean age of 38±16.9 years. There were 64(79%) male patients. Overall the incidence of malrotation was in 20(24.7%) cases. Rotational mal-alignment is one of the preventable complications after IMnailing which can be assesed intra-operatively under fluoroscope.

  1. SmartMal: a service-oriented behavioral malware detection framework for mobile devices.

    Science.gov (United States)

    Wang, Chao; Wu, Zhizhong; Li, Xi; Zhou, Xuehai; Wang, Aili; Hung, Patrick C K

    2014-01-01

    This paper presents SmartMal--a novel service-oriented behavioral malware detection framework for vehicular and mobile devices. The highlight of SmartMal is to introduce service-oriented architecture (SOA) concepts and behavior analysis into the malware detection paradigms. The proposed framework relies on client-server architecture, the client continuously extracts various features and transfers them to the server, and the server's main task is to detect anomalies using state-of-art detection algorithms. Multiple distributed servers simultaneously analyze the feature vector using various detectors and information fusion is used to concatenate the results of detectors. We also propose a cycle-based statistical approach for mobile device anomaly detection. We accomplish this by analyzing the users' regular usage patterns. Empirical results suggest that the proposed framework and novel anomaly detection algorithm are highly effective in detecting malware on Android devices.

  2. ANALISA PERBEDAAN MOTIVASI DAN PERSEPSI BERBELANJA DI MAL ANTARA ORANG TUA (IBU DAN PARA REMAJA PUTRINYA

    Directory of Open Access Journals (Sweden)

    Sasung Luckytawati

    2008-10-01

    The conceptual framework consists of the following constructs: consumption motivation social and con umption motivation objective as independent variables, and Mall Perception that consist ambience, design, layout, variety, excitement, involvement, desire to stay and desire to return as dependent variable. Moreover, five hypotheses were developed and tested. instrument test of validity and reliability used to test the measures, while independent t-test and multiple regressions were used in hypotheses testing. Data were collected from 100 dyadic pairs of mothers and daughters who had recently visited Mal at Jakarta. The resuIts indicate that mothers and daughters are motivated to consume by different factors, and tha they differ significantly in terms of their perceptions of critical mal environmental variables. Keywords: Consumption motivation social, Consumer behaviour, Mall Perception, and Design factors.

  3. Delayed surgical treatment for neglected or mal-reduced talar fractures.

    Science.gov (United States)

    Huang, Peng-Ju; Cheng, Yuh-Min

    2005-10-01

    From 1993 to 2002, we treated nine patients for neglected or mal-reduced talar fractures. Average patient age was 39 (20-64) years and average follow-up 53 months. The time interval between injury and index operation ranged from 4 weeks to 4 years. Surgical procedures included open reduction with or without bone grafting in six cases, open reduction combined with ankle fusion in one case, talar neck osteotomy in one case, and talar neck osteotomy combined with subtalar fusion in one case. All cases had solid bone union. One patient developed avascular necrosis of the talus needing subsequent ankle arthrodesis. In six patients, adjacent hindfoot arthrosis occurred. The overall AOFAS ankle-hindfoot score was in average 77.4. We conclude that in neglected and mal-reduced talar fractures, surgical treatment can lead to a favourable outcome if the hindfoot joints are not arthritic.

  4. Ablative fractional laser enhances MAL-induced PpIX accumulation

    DEFF Research Database (Denmark)

    Haak, C S; Christiansen, K; Erlendsson, Andrés M

    2016-01-01

    BACKGROUND AND OBJECTIVES: Pretreatment of skin with ablative fractional laser enhances accumulation of topical provided photosensitizer, but essential information is lacking on the interaction between laser channel densities and pharmacokinetics. Hence our objectives were to investigate how...... (range 46-133min) induced fluorescence levels similar to curettage and 180min incubation. Furthermore, MAL 80 and 160mg/g induced similar fluorescence intensities in skin exposed to laser densities of 1, 2 and 5% (p>0.0537, 30-180min). CONCLUSION: MAL-induced protoporphyrin accumulation is augmented...... protoporphyrin accumulation was affected by laser densities, incubation time and drug concentration. METHODS: We conducted the study on the back of healthy male volunteers (n=11). Test areas were pretreated with 2940nm ablative fractional Er:YAG laser, 11.2mJ per laser channel using densities of 1, 2, 5, 10...

  5. Structure of the conserved hypothetical protein MAL13P1.257 from Plasmodium falciparum

    International Nuclear Information System (INIS)

    Holmes, Margaret A.; Buckner, Frederick S.; Van Voorhis, Wesley C.; Mehlin, Christopher; Boni, Erica; Earnest, Thomas N.; DeTitta, George; Luft, Joseph; Lauricella, Angela; Anderson, Lori; Kalyuzhniy, Oleksandr; Zucker, Frank; Schoenfeld, Lori W.; Hol, Wim G. J.; Merritt, Ethan A.

    2006-01-01

    The crystal structure of a conserved hypothetical protein, MAL13P1.257 from P. falciparum, has been determined at 2.17 Å resolution. The structure represents a new protein fold and is the first structural representative for Pfam sequence family PF05907. The structure of a conserved hypothetical protein, PlasmoDB sequence MAL13P1.257 from Plasmodium falciparum, Pfam sequence family PF05907, has been determined as part of the structural genomics effort of the Structural Genomics of Pathogenic Protozoa consortium. The structure was determined by multiple-wavelength anomalous dispersion at 2.17 Å resolution. The structure is almost entirely β-sheet; it consists of 15 β-strands and one short 3 10 -helix and represents a new protein fold. The packing of the two monomers in the asymmetric unit indicates that the biological unit may be a dimer.

  6. Torsional vibration analysis in turbo-generator shaft due to mal-synchronization fault

    Science.gov (United States)

    Bangunde, Abhishek; Kumar, Tarun; Kumar, Rajeev; Jain, S. C.

    2018-03-01

    A rotor of turbo-generator shafting is many times subjected to torsional vibrations during its lifespan. The reasons behind these vibrations are three-Phase fault, two-phase fault, line to ground fault, faulty-mal synchronization etc. Sometimes these vibrations can cause complete failure of turbo-generator shafting system. To calculate moment variation during these faults on the shafting system vibration analysis is done using Finite Elements Methods to calculate mass and stiffness matrix. The electrical disturbance caused during Mal-synchronization is put on generator section, and corresponding second order equations are solved by using “Duhamel Integral”. From the moment variation plots at four sections critically loaded sections are identified.

  7. Magnetic moment of short lived {beta}-emitter {sup 24m}Al

    Energy Technology Data Exchange (ETDEWEB)

    Nishimura, D., E-mail: daiki@vg.phys.sci.osaka-u.ac.jp; Komurasaki, J.; Matsuta, K.; Mihara, M.; Matsumiya, R. [Osaka University, Department of Physics (Japan); Momota, S. [Kochi University of Technology (Japan); Ohtsubo, T. [Niigata University, Department of Physics (Japan); Izumikawa, T. [Niigata University, RI Center (Japan); Hirano, H. [Niigata University, Department of Physics (Japan); Kitagawa, A.; Kanazawa, M.; Torikoshi, M.; Sato, S. [National Institute of Radiological Sciences (Japan); Fukuda, M.; Ishikawa, D. [Osaka University, Department of Physics (Japan); Minamisono, T. [Fukui University of Technology (Japan); Watanabe, R.; Kubo, T. [Niigata University, Department of Physics (Japan); Nojiri, Y. [Kochi University of Technology (Japan); Alonso, J. R. [Lawrence Berkeley Laboratory (United States)

    2007-11-15

    The magnetic moment of short lived {beta}-emitter {sup 24m}Al (426 keV, I{sup {pi}} = 1{sup +}, T{sub 1/2} = 131 ms) has been measured by means of {beta}-NMR technique, for the first time. From the {beta}-NMR spectrum, the magnetic moment was determined as |{mu}({sup 24m}Al)|=(2.99{+-}0.09){mu}{sub N}. Combined with the known magnetic moment of the mirror partner {sup 24m}Na, the expectation value of < S{sub z} > is obtained to be (0.08 {+-} 0.12). These values are reproduced well by the shell model calculation.

  8. Theoretical Characteristics of Metalloporphyrins (OEP) M (CH 3 ) (M=Al, Ga, In and Tl)

    OpenAIRE

    Lepetit , M.B.; Kabbaj , O.K.; Zrineh , A.

    2017-01-01

    International audience; A theoretical study of metalloporphyrins molecules (OEP) M (CH 3) (M=Al, Ga, In and Tl) are brought to a few experimental data and to give background for future development of these complexes. The Quantum Chemistry Program (ORCA) program package based on Density Functional Theory (DFT) and Time-dependent Density Functional Theory (TDDFT) for transitions at the B3LYP level with ANO 2ζ+P base was used for calculations and determination of structural properties, electroni...

  9. The (Mal)Practice of Dowry in Contemporary India. A Challenge to Marriage and Family Ministry

    OpenAIRE

    Jainus Xavier, Nixen Raj; Jainus Xavier, Nixen Raj; Knieps-Port le Roi, Thomas

    2012-01-01

    The author explores the (mal)practice of dowry in contemporary India and the challenge it presents to marriage and family ministry. He explains how originally harmless and well-intended dowry customs changed under the influence of historical circumstances that turned them into a business-like family strategy aimed at rising families’ social status, wealth and power. This evolution had dramatic consequences for Indian marriage and family life and especially for women. Dowry-related violence an...

  10. Hybrid (laparoscopy + stent) treatment of celiac trunk compression syndrome (Dunbar syndrome, median arcuate ligament syndrome (MALS)).

    Science.gov (United States)

    Michalik, Maciej; Dowgiałło-Wnukiewicz, Natalia; Lech, Paweł; Majda, Kaja; Gutowski, Piotr

    2016-01-01

    Celiac trunk (CT) compression syndrome caused by the median arcuate ligament (MAL) is a rarely diagnosed disease because of its nonspecific symptoms, which cause a delay in the correct diagnosis. Intestinal ischemia occurs, which causes symptoms of abdominal angina. One method of treatment for this disease is surgical release of the CT - the intersection of the MAL. Laparoscopy is the first step of the hybrid technique combined with percutaneous angioplasty and stenting of the CT. To demonstrate the usefulness and advantages of the laparoscopic approach in the treatment of Dunbar syndrome. Between 2013 and 2016 in the General and Minimally Invasive Surgery Department of the Medical Sciences Faculty of the University of Warmia and Mazury in Olsztyn, 6 laparoscopic procedures were performed because of median arcuate ligament syndrome. During the laparoscopy the MAL was cut with a harmonic scalpel. One month after laparoscopy 5 patients had Doppler percutaneous angioplasty of the CT with stent implantation in the Vascular Surgery Department in Pomeranian Medical University in Szczecin. In one case, there was a conversion of laparoscopic surgery to open due to unmanageable intraoperative bleeding. In one case, postoperative ultrasound examination of the abdominal cavity demonstrated the presence of a large hematoma in the retroperitoneal space. All patients reported relief of symptoms in the first days after the operation. The hybrid method, combining laparoscopy and angioplasty, seems to be a long-term solution, which increases the comfort of the patient, brings the opportunity for normal functioning and minimizes the risk of restenosis.

  11. MAL2 and tumor protein D52 (TPD52 are frequently overexpressed in ovarian carcinoma, but differentially associated with histological subtype and patient outcome

    Directory of Open Access Journals (Sweden)

    Fanayan Susan

    2010-09-01

    Full Text Available Abstract Background The four-transmembrane MAL2 protein is frequently overexpressed in breast carcinoma, and MAL2 overexpression is associated with gain of the corresponding locus at chromosome 8q24.12. Independent expression microarray studies predict MAL2 overexpression in ovarian carcinoma, but these had remained unconfirmed. MAL2 binds tumor protein D52 (TPD52, which is frequently overexpressed in ovarian carcinoma, but the clinical significance of MAL2 and TPD52 overexpression was unknown. Methods Immunohistochemical analyses of MAL2 and TPD52 expression were performed using tissue microarray sections including benign, borderline and malignant epithelial ovarian tumours. Inmmunohistochemical staining intensity and distribution was assessed both visually and digitally. Results MAL2 and TPD52 were significantly overexpressed in high-grade serous carcinomas compared with serous borderline tumours. MAL2 expression was highest in serous carcinomas relative to other histological subtypes, whereas TPD52 expression was highest in clear cell carcinomas. MAL2 expression was not related to patient survival, however high-level TPD52 staining was significantly associated with improved overall survival in patients with stage III serous ovarian carcinoma (log-rank test, p Conclusions MAL2 is frequently overexpressed in ovarian carcinoma, and TPD52 overexpression is a favourable independent prognostic marker of potential value in the management of ovarian carcinoma patients.

  12. Maltase protein of Ogataea (Hansenula) polymorpha is a counterpart to the resurrected ancestor protein ancMALS of yeast maltases and isomaltases

    Science.gov (United States)

    Viigand, Katrin; Visnapuu, Triinu; Mardo, Karin; Aasamets, Anneli

    2016-01-01

    Abstract Saccharomyces cerevisiae maltases use maltose, maltulose, turanose and maltotriose as substrates, isomaltases use isomaltose, α‐methylglucoside and palatinose and both use sucrose. These enzymes are hypothesized to have evolved from a promiscuous α‐glucosidase ancMALS through duplication and mutation of the genes. We studied substrate specificity of the maltase protein MAL1 from an earlier diverged yeast, Ogataea polymorpha (Op), in the light of this hypothesis. MAL1 has extended substrate specificity and its properties are strikingly similar to those of resurrected ancMALS. Moreover, amino acids considered to determine selective substrate binding are highly conserved between Op MAL1 and ancMALS. Op MAL1 represents an α‐glucosidase in which both maltase and isomaltase activities are well optimized in a single enzyme. Substitution of Thr200 (corresponds to Val216 in S. cerevisiae isomaltase IMA1) with Val in MAL1 drastically reduced the hydrolysis of maltose‐like substrates (α‐1,4‐glucosides), confirming the requirement of Thr at the respective position for this function. Differential scanning fluorimetry (DSF) of the catalytically inactive mutant Asp199Ala of MAL1 in the presence of its substrates and selected monosaccharides suggested that the substrate‐binding pocket of MAL1 has three subsites (–1, +1 and +2) and that binding is strongest at the –1 subsite. The DSF assay results were in good accordance with affinity (K m) and inhibition (K i) data of the enzyme for tested substrates, indicating the power of the method to predict substrate binding. Deletion of either the maltase (MAL1) or α‐glucoside permease (MAL2) gene in Op abolished the growth of yeast on MAL1 substrates, confirming the requirement of both proteins for usage of these sugars. © 2016 The Authors. Yeast published by John Wiley & Sons, Ltd. PMID:26919272

  13. Relationship between diet and benign prostatic hyperplasia Relación entre la dieta y el desarrollo de Hiperplasia Prostática Benigna: ¿Qué nos dice la evidencia científica actual?

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    Jon Kepa Balparda Arias

    2010-02-01

    Full Text Available

    Benign prostatic hyperplasia is very common in the general population, both from the histological and the clinical points of view. The role of different factors in its development has been defined by means of epidemiological studies. One such factor is the composition of the diet, as the regular consumption of certain foods may either protect against benign prostatic hyperplasia or increase the risk of its development. Among foods which may play a protective role are lycopene, phytoestrogens and vegetables. On the other hand, the risk of developing the disease may be increased by a diet rich in fat and calories. In this article the main clinical trials concerning this relationship are reviewed, as a way of informing physicians on the dietetic patterns that may influence the frequency or the symptoms of this disease.

    La hiperplasia prostática benigna es muy común en la población general, tanto desde el punto de vista histológico como del clínico. El papel en ella de diversos factores se ha definido por medio de estudios epidemiológicos. Entre ellos está el consumo regular de algunos alimentos que podría actuar como un factor protector o de riesgo para el posterior desarrollo de la enfermedad. Entre los compuestos demostrados como benéficos para la salud prostática están los licopenos, los fitoestrógenos y las verduras. Por otro lado, entre los que podrían aumentar el riesgo de sufrir la hiperplasia prostática benigna se incluyen las dietas hipercal

  14. Trabalhador portuário: perfil de doenças ocupacionais diagnosticadas em serviço de saúde ocupacional Trabajador portuario: perfil de enfermedades ocupacionales diagnosticadas en un servicio de salud ocupacional Dock worker: profile of occupational diseases diagnosed in an occupational health service

    Directory of Open Access Journals (Sweden)

    Marlise Capa Verde de Almeida

    2012-01-01

    Full Text Available OBJETIVO: Identificar as doenças diagnosticadas em trabalhadores portuários avulsos, atendidos em um ambulatório de medicina do trabalho portuário. MÉTODOS: Estudo quantitativo descritivo com análise retrospectiva, que apresentou como fonte de dados as fichas de atendimento médico dos trabalhadores portuários avulsos entre 2000 e 2009. A coleta de dados desenvolveu-se mediante aplicação de um formulário predeterminado e procedeu-se à análise quantitativa descritiva em 953 fichas médicas dos trabalhadores. RESULTADOS: totalizou-se 953 fichas médicas (94,7%, das quais 90,47% pertenciam a trabalhadores do sexo masculino, 52% na faixa etária acima de 50 anos e 51,7% com mais de 19 anos de atuação. Identificaram-se 527 diagnósticos, sendo os principais relacionados ao trabalho: hipertensão (8,3%, lombalgia (6,2%, outras doenças pulmonares (1,7% e episódios depressivos (1,2%. CONCLUSÃO: constatou-se o acometimento do trabalhador por patologias ocupacionais de ordem mental, circulatória, respiratória e osteomuscular, evidenciando morbidades que o afetam e interferem em sua qualidade de vida e na produtividade das atividades laborais.OBJETIVO: Identificar las enfermedades diagnosticadas en trabajadores portuarios independientes, atendidos en un consultorio externo de medicina del trabajo portuario. MÉTODOS: Estudio cuantitativo descriptivo con análisis retrospectivo, que presentó como fuente de datos las fichas de atención médica de los trabajadores portuarios independientes entre 2000 y 2009. La recolección de los datos se desarrolló mediante la aplicación de un formulario estructurado y se procedió a realizar el análisis cuantitativo descritivo de 953 fichas médicas de los trabajadores. RESULTADOS: De un total de 953 fichas médicas (94,7%, el 90,47% pertenecían a trabajadores del sexo masculino, el 52% se encontraba en el grupo etáreo arriba de los 50 años y el 51,7% con más de 19 años de actuación. Se

  15. Performances of air source heat pump system for a kind of mal-defrost phenomenon appearing in moderate climate conditions

    International Nuclear Information System (INIS)

    Wang, W.; Feng, Y.C.; Zhu, J.H.; Li, L.T.; Guo, Q.C.; Lu, W.P.

    2013-01-01

    Highlights: ► Mal-defrost performances of ASHP in moderate environment are investigated. ► The system COP decreases to 2.3 under environment temperature of 7.9 °C. ► The decrease of the ASHP heating capacity can get to 43.4%. ► The origins of this special mal-defrost phenomenon were discussed. ► Suggestions were proposed to modify the current defrosting control strategies. - Abstract: To quantify the performance drop of the air source heat pump (ASHP) system under a special kind of mal-defrost phenomenon appearing in moderate climate conditions, a field test was conducted for 8 days at the initial stage of a heating season in Beijing, China. The mal-defrost was found with the more than 60% frosted area of the outdoor heat exchanger after the system running 5 days. During this frosting period, the system COP was significantly degraded, only 2.3 under an environment temperature of 7.9 °C. Comparing the test data before and after frosting, it was found that the mal-defrost decreased the COP up to 40.4% and the heating capacity to 43.4%. Such low energy efficiency continued quite a long time until the defrost control was started up manually by the authors. After defrosting, the COP reclaimed to the normal level of 5.0. The origins of this special mal-defrost phenomenon were discussed. And some suggestions were proposed to modify the current defrosting control strategy, which were helpful to avoid the mal-defrost problem in the current ASHP system and therefore improve the system performances

  16. Pequeno mal epiléptico em crianças. Considerações sobre o efeito do tridione em 4 casos

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    Antonio B. Lefévre

    1949-03-01

    Full Text Available The author administered Tridione in four patients under five years of age with "petit mal" seizures. In all cases there was complete disappearance of the seizures eventhough small doses were used. In one case the EEG, taken after the Tridione treatment, did not show the previous "petit mal" pattern. In no case there were signs of intolerance. In conclusion the author thoroughly agree that Tridione is the drug of choice in "petit mal" seizures.

  17. DMPD: The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 17449723 The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling. Sh...Show The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling. PubmedID 17449723 Title The Tro...ll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling. Authors Sheedy F

  18. Luminescence properties of Eu2+-doped MAl2-xSixO4-xNx (M = Ca, Sr, Ba) conversion phosphor for white LED applications

    NARCIS (Netherlands)

    Li, Y.Q.; With, de G.; Hintzen, H.T.J.M.

    2006-01-01

    Undoped and Eu-doped MAl2-xSixO4-2Nx (M = Ca, Sr, Ba) were synthesized by a solid-state reaction method at 1300 - 1400 ¿C under nitrogen-hydrogen atmosphere. The solubility of (SiN)+, in MAl2O4 was determined. Nitrogen can be incorporated into MAl2O4 by replacement of (AlO)+ by (SiN)+, whose amount

  19. Malária grave em gestantes Severe malaria in pregnant women

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    Flavia Barbosa Fernandes

    2010-12-01

    Full Text Available OBJETIVO: analisar a evolução clínica de três pacientes grávidas com malária grave internadas em unidade de terapia intensiva de um hospital localizado em Porto Velho (RO. MÉTODOS: foi realizado estudo descritivo em três gestantes, portadoras de malária por Plasmodium falciparum, internadas em unidade de terapia intensiva em Porto Velho, no período de 2005 a 2006. As variáveis categóricas utilizadas foram os critérios de classificação da Organização Mundial de Saúde para classificação de malária grave e os índices Acute Physiology and Chronic Health disease Classification System II (APACHE II e Sepsis Related Organ Failure Assessment (SOFA preditores de morbidade e gravidade das doenças em unidade de terapia intensiva. RESULTADOS: a malária adquirida pelas gestantes, caracterizada pela infecção por Plasmodium falciparum na forma grave da doença, resultou em óbito para as três pacientes e seus conceptos. CONCLUSÕES: embora a casuística seja pequena, a importância deste estudo reflete a repercussão da malária grave em gestantes, bem como a necessidade de um acompanhamento pré-natal mais criterioso e atento à identificação precoce do início das complicações da malária em gestantes.PURPOSE: to analyze the clinical course of three pregnant patients with severe malaria admitted to the intensive care unit of a hospital in Porto Velho (RO, Brazil. METHODS: a descriptive study was conducted on three pregnant women infected with Plasmodium falciparum malaria, admitted to the intensive care unit of a hospital in Porto Velho from 2005 to 2006. Categorical variables used were the classification criteria of the World Health Organization which ranks severe malaria and the Acute Physiology and Chronic Health Disease Classification System II (APACHE II and Sepsis Related Organ Failure Assessment (SOFA predictors of morbidity and severity of intensive care unit diseases. RESULTS: the malaria acquired by the pregnant

  20. Hybrid (laparoscopy + stent treatment of celiac trunk compression syndrome (Dunbar syndrome, median arcuate ligament syndrome (MALS

    Directory of Open Access Journals (Sweden)

    Maciej Michalik

    2016-12-01

    Full Text Available Introduction : Celiac trunk (CT compression syndrome caused by the median arcuate ligament (MAL is a rarely diagnosed disease because of its nonspecific symptoms, which cause a delay in the correct diagnosis. Intestinal ischemia occurs, which causes symptoms of abdominal angina. One method of treatment for this disease is surgical release of the CT – the intersection of the MAL. Laparoscopy is the first step of the hybrid technique combined with percutaneous angioplasty and stenting of the CT. Aim: To demonstrate the usefulness and advantages of the laparoscopic approach in the treatment of Dunbar syndrome. Material and methods : Between 2013 and 2016 in the General and Minimally Invasive Surgery Department of the Medical Sciences Faculty of the University of Warmia and Mazury in Olsztyn, 6 laparoscopic procedures were performed because of median arcuate ligament syndrome. During the laparoscopy the MAL was cut with a harmonic scalpel. One month after laparoscopy 5 patients had Doppler percutaneous angioplasty of the CT with stent implantation in the Vascular Surgery Department in Pomeranian Medical University in Szczecin. Results : In one case, there was a conversion of laparoscopic surgery to open due to unmanageable intraoperative bleeding. In one case, postoperative ultrasound examination of the abdominal cavity demonstrated the presence of a large hematoma in the retroperitoneal space. All patients reported relief of symptoms in the first days after the operation. Conclusions : The hybrid method, combining laparoscopy and angioplasty, seems to be a long-term solution, which increases the comfort of the patient, brings the opportunity for normal functioning and minimizes the risk of restenosis.

  1. PERTANGGUNGAN JAWAB PIDANA PEJABAT ATAS TINDAKAN MAL-ADMINISTRASI DALAM PENERBITAN IZIN DI BIDANG LINGKUNGAN

    Directory of Open Access Journals (Sweden)

    Ahmad Basuki

    2011-09-01

    Full Text Available The democratic strengthen is very influencing to the demand of good governance in managing the government. One of the positive demand is it has been adopted the principle of accountability of the constitution of protection and management of environment for official functionary on the act of mal administration in establishing permit of environment field, Based on the principle community who become sacrifice of pollution of environment can appeal the legal permit and the responsibility of criminal case towards the official functionary of disadvantages they have got.

  2. Kärnproblem : opinionsbildning i kärnavfallsdiskursen i Malå

    OpenAIRE

    Sjölander, Annika

    2004-01-01

    At the centre of this study lies one of the critical questions faced by (late-)modern society, namely that of taking care of the long-lived radioactive waste from nuclear power production. The problems of nuclear waste management are pictured as embracing a complex web of essential issues for society today, in terms of both its capacities and its shortcomings – so called core issues. The principal aim of the thesis is to examine the nuclear waste discourse in Malå, Västerbotten, from a critic...

  3. No hay mal que por bien no venga: el optimismo según Rousseau

    OpenAIRE

    Baranzelli, Dante A.

    2004-01-01

    El deísmo rousseauniano desestima la existencia del caos o del Mal general. Por el contrario, ve en el sistema del mundo un orden perfecto que obedece a la divina Providencia, identificada con la legalidad universal de la naturaleza. Mas con ello su intención no es despreciar el sufrimiento de los individuos. De hecho Rousseau reconoce y admite la presencia, e incluso la abundancia, de diversos males que afectan al hombre. ¿Acaso él mismo no es un claro ejemplo de ello?

  4. Escaping History: Benjamin Fondane's 'Mal des fantômes' and Interiority

    OpenAIRE

    Dickow, A

    2017-01-01

    AbstractThis article undertakes a detailed comparison of the work of Emmanuel Levinas and the poet-philosopher Benjamin Fondane. Fondane’s most iconic poem, quoted at the entrance to the Hall of Names in Jerusalem’s Holocaust museum, resembles a poetic illustration of Levinas’s key themes, such as the ‘face’ and the concept of ‘ethical speech.’ Likewise, Fondane’s long poem ‘Le Mal des fantômes’ illustrates Levinas and Fondane’s shared conception of the subject’s interiority and day-to-day ex...

  5. Exposure to Glycolytic Carbon Sources Reveals a Novel Layer of Regulation for the MalT Regulon

    Directory of Open Access Journals (Sweden)

    Sylvia A. Reimann

    2011-01-01

    Full Text Available Bacteria adapt to changing environments by means of tightly coordinated regulatory circuits. The use of synthetic lethality, a genetic phenomenon in which the combination of two nonlethal mutations causes cell death, facilitates identification and study of such circuitry. In this study, we show that the E. coli ompR malTcon double mutant exhibits a synthetic lethal phenotype that is environmentally conditional. MalTcon, the constitutively active form of the maltose system regulator MalT, causes elevated expression of the outer membrane porin LamB, which leads to death in the absence of the osmoregulator OmpR. However, the presence and metabolism of glycolytic carbon sources, such as sorbitol, promotes viability and unveils a novel layer of regulation within the complex circuitry that controls maltose transport and metabolism.

  6. Access to health care and undiagnosed diabetes along the United States-Mexico border Acceso a la atención de salud y diabetes no diagnosticada a lo largo de la frontera México-Estados Unidos

    Directory of Open Access Journals (Sweden)

    Xuanping Zhang

    2010-09-01

    Full Text Available OBJETIVE: To examine the relationship between access to health care and undiagnosed diabetes among the high-risk, vulnerable population in the border region between the United States of America and Mexico. METHODS: Using survey and fasting plasma glucose data from Phase I of the U.S.-Mexico Border Diabetes Prevention and Control Project (February 2001 to October 2002, this epidemiological study identified 178 adults 18-64 years old with undiagnosed diabetes, 326 with diagnosed diabetes, and 2 966 without diabetes. Access to health care among that sample (n = 3 470, was assessed by type of health insurance coverage (including "none", number of health care visits over the past year, routine pattern of health care utilization, and country of residence. RESULTS: People with diabetes who had no insurance and no place to go for routine health care were more likely to be undiagnosed than those with insurance and a place for routine health care (odds ratio [OR] 2.6, 95% confidence interval [CI] 1.0-6.6, and OR 4.5, 95% CI 1.4-14.1, respectively. When stratified by country, the survey data showed that on the U.S. side of the border there were more people with undiagnosed diabetes if they were 1 uninsured versus the insured (28.9%, 95% CI 11.5%-46.3%, versus 9.1%, 95% CI 1.5%-16.7%, respectively and if they 2 had made no visits or 1-3 visits to a health care facility in the past year versus had made > 4 visits (40.8%, 95% CI 19.6%-62.0%, and 23.4%, 95% CI 9.9%-36.9%, respectively, versus 2.4%, 95% CI -0.9%-5.7% (all, P OBJETIVO: Examinar la relación entre el acceso a la atención de salud y la diabetes no diagnosticada en la población de alto riesgo y vulnerable de la zona fronteriza entre México y los Estados Unidos. MÉTODOS: Mediante el uso de los datos de la encuesta y de la glucosa plasmática en ayunas de la fase I del Proyecto de Prevención y Control de la Diabetes en la Frontera México-Estados Unidos (de febrero del 2001 a octubre del 2002

  7. De culpable a perseguido: Baudelaire y el proceso de Las Flores del Mal

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    Juan Zapata

    2018-01-01

    Full Text Available ¿Cómo el poeta de Las Flores del Mal pasó de ser un escritor proscrito, y en consecuencia sospechoso, al autor perseguido e incomprendido que ha inmortalizado la historia literaria? ¿Cómo Baudelaire pudo desviar a su favor una circunstancia que, a primera  vista, era desafortunada? Baudelaire supo utilizar el escándalo que provocó la publicación de Las Flores del Mal para promover su figura pública. Un análisis de las posturas discursivas desplegadas por Baudelaire antes, durante y después del proceso nos permitirá comprender mejor la inversión que el poeta hace de su condenación, al transformar la sanción penal y moral, así como la exclusión a la que esta conduce, en un signo de su grandeza y de su gloria póstuma.

  8. A review of the prevalence and factors responsible for mal-nutrition in Pakistan

    Directory of Open Access Journals (Sweden)

    Hafsa Hina

    2015-01-01

    Full Text Available Problems occupying special attention identified by the World Health Organization also include Childhood malnutrition (Beagle hole et al., 1993. Development goals are also program by the United Nations to halve the problem of under nutrition (Alderman et al., 2005. Despite of the involvement of international organizations still under nutrition has a main contribution to the high mortality rate of the children in the most part of the world (Caulfield et al., 2004. Poverty plays a main part in the high prevalence of childhood under nutrition. The child is said to be under-weight when its weight is lower than the weight of the reference rage for that age. The weight for height deficiency is known as wasting, while height for age deficiency as stunting. Wasting may be due to acute food shortage while prolonged food deprivation can cause stunting (Cosminsky et al., 1993; de Onis et al., 2000; Fernandez et al., 2002; and Zere & McIntyre, 2003. The factors responsible for the predisposition of children to mal nutrition vary and ranges from political instability to the economical status of the area (de Onis et al., 2000. Therefore protocols developed for the preventive measures of mal-nutrition should be multifaceted. 

  9. Olhar de dirigentes sindicais sobre qualidade de vida no trabalho e mal-estar no trabalho

    Directory of Open Access Journals (Sweden)

    Remigio Todeschini

    2013-06-01

    Full Text Available O objeto do artigo consistiu em conhecer as percepções de dirigentes sindicais metalúrgicos e químicos sobre o tema Qualidade de Vida no Trabalho (QVT e as fontes de mal-estar no trabalho nessas categorias profissionais. A natureza metodológica aplicada foi quantitativa e qualitativa com utilização do software Alceste. Participaram da pesquisa 81 dirigentes sindicais brasileiros (56 dirigentes químicos e 25 metalúrgicos, 85% do gênero masculino e 15% do gênero feminino oriundos das regiões sudeste, sul e nordeste do país, com aplicação do questionário via e-mail. Os resultados encontrados forneceram bases empíricas para a formulação de recomendações em Ergonomia da Atividade visando prevenir as fontes de mal-estar no trabalho. Foram reforçadas as bases teóricas da Abordagem de Ergonomia da Atividade Aplicada à Qualidade de Vida no Trabalho (EAA_QVT e o desenho de subsídios para a formulação de políticas públicas neste campo.

  10. The use of plasma rich in growth factors (PRGF-Endoret) in the treatment of a severe mal perforant ulcer in the foot of a person with diabetes.

    Science.gov (United States)

    Orcajo, Beatriz; Muruzabal, Francisco; Isasmendi, María Concepción; Gutierrez, Nerea; Sánchez, Mikel; Orive, Gorka; Anitua, Eduardo

    2011-08-01

    A 71 year old person with diabetes with a severe mal perforant ulcer in the right foot was treated twice with autologous plasma-rich in growth factors (PRGF) obtained from her own blood. After PRGF treatment the severe mal perforant ulcer completely healed in 10 weeks. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  11. Association of Mal/TIRAP S180L variant polymorphism with decreased infection risk in patients with advanced HIV-1 infection.

    NARCIS (Netherlands)

    Papadopoulos, A.I.; Ferwerda, B.; Antoniadou, A.; Sakka, V.; Galani, L.; Kavatha, D.; Panagopoulos, P.; Poulakou, G.; Protopapas, K.; Meer, J.W.M. van der; Netea, M.G.; Giamarellos-Bourboulis, E.J.

    2012-01-01

    OBJECTIVES: MyD88 adaptor-like (Mal/TIRAP) is an adaptor protein bridging activation of Toll-like receptors 2 and 4 after stimulation by exogenous and endogenous ligands. We investigated the association between the presence of the S180L SNP of Mal and the risk of severe infection in individuals with

  12. Role of Helicobacter pylori in stomach cancer after partial gastrectomy for benign ulcer disease Papel del Helicobacter pylori en el cáncer gástrico tras gastrectomía parcial por úlcera benigna

    Directory of Open Access Journals (Sweden)

    A. Seoane

    2005-11-01

    Full Text Available Objective: to determine the prevalence of Helicobacter pylori infection in patients having undergone gastrectomy for non-neoplastic disease who later developed gastric stump cancer. Material and methods: retrospective study of all patients with partial gastrectomy for non-malignant peptic disease who were submitted to an endoscopic exploration between 1995 and 2001. A comparison was made of major clinical and histological characteristics, and the presence of Helicobacter pylori among patients with and without gastric cancer in the stomach remnant. Results: a total of 73 patients were studied in this period. Fifteen patients (20.5% had remnant-stump gastric cancer. All but one were adenocarcinomas (71% intestinal and 29% diffuse, respectively. The average time between diagnosis of gastric cancer and previous gastrectomy was 32 (14-48 years. There was a higher detection rate of Helicobacter pylori in patients with cancer in the gastric remnant (100 vs. 81.5%, respectively, p Objetivo: determinar la prevalencia de la infección por Helicobacter pylori en pacientes gastrectomizados por enfermedad no neoplásica, y que han desarrollado posteriormente cáncer gástrico. Material y métodos: estudio retrospectivo con reclutamiento de todos los pacientes con gastrectomía parcial por enfermedad péptica benigna que han sido sometidos a una exploración endoscópica entre 1995-2001. Se ha realizado una comparación de las principales características clínicas e histológicas y de la presencia de Helicobacter pylori en los pacientes con y sin cáncer del remanente gástrico. Resultados: se han estudiado un total de 73 pacientes en este periodo. Se han encontrado 15 pacientes (20,5% con cáncer en el remanente gástrico, 14 adenocarcinomas (71% tipo intestinal y 29% tipo difuso y un linfoma. El tiempo transcurrido entre el diagnóstico de cáncer gástrico y la gastrectomía previa ha sido de 32 (14-48 años. Se ha detectado un alto porcentaje de infecci

  13. Estenoses benignas de esôfago: abordagem endoscópica com velas de Savary-Gilliard Benign strictures of the esophagus: endoscopic approach with Savary-Gilliard bougies

    Directory of Open Access Journals (Sweden)

    Paula Novais

    2008-12-01

    Full Text Available RACIONAL: As estenoses benignas de esôfago são complicações decorrentes de diversas causas. Possuem tratamentos similares, na maioria dos casos necessitando de dilatação endoscópica, no entanto a resposta terapêutica, tempo ideal de tratamento, assim como intervalo entre as sessões podem ser variáveis. OBJETIVO: Analisar, do ponto de vista endoscópico, as estenoses benignas de esôfago em 14 anos de experiência no Hospital Universitário Clementino Fraga Filho da Universidade Federal do Rio de Janeiro, RJ, avaliando etiologia, a extensão da estenose, o número de dilatações necessário para atingir resposta terapêutica satisfatória, assim como a relação entre a extensão da estenose e a resposta terapêutica. MÉTODO: Foram analisadas 2.568 dilatações endoscópicas com uso de velas de Savary-Gilliard em 236 pacientes, durante um período de 14 anos e 10 meses, até junho de 2007. RESULTADOS: A estenose péptica foi a causa mais freqüentemente encontrada, seguida pela estenose cáustica. As estenoses longas e cáusticas necessitaram de maior número de sessões para ausência de disfagia. Estenoses pépticas e curtas responderam melhor a número menor de sessões de dilatação. CONCLUSÃO: A estenose péptica foi a causa mais comum e respondeu bem à terapia endoscópica, em concordância com a literatura. As estenoses cáusticas foram as mais refratárias, principalmente as longas. Quanto maior foi a extensão da estenose, também maior foi o número de sessões necessárias. Estenoses curtas apresentaram boa evolução na maioria dos casos. O número de dilatações necessárias dependeu diretamente da causa e da extensão da estenose.BACKGROUND: Benign esophageal strictures are complications that result from different causes. They are usually similarly approached, most of the cases needing endoscopic dilation. However the response to therapy, optimal timing for treatment and interval between sessions can vary. AIM: The

  14. MAL2 and tumor protein D52 (TPD52) are frequently overexpressed in ovarian carcinoma, but differentially associated with histological subtype and patient outcome

    International Nuclear Information System (INIS)

    Byrne, Jennifer A; Sutherland, Robert L; Fazio, Anna de; O'Brien, Philippa M; Maleki, Sanaz; Hardy, Jayne R; Gloss, Brian S; Murali, Rajmohan; Scurry, James P; Fanayan, Susan; Emmanuel, Catherine; Hacker, Neville F

    2010-01-01

    The four-transmembrane MAL2 protein is frequently overexpressed in breast carcinoma, and MAL2 overexpression is associated with gain of the corresponding locus at chromosome 8q24.12. Independent expression microarray studies predict MAL2 overexpression in ovarian carcinoma, but these had remained unconfirmed. MAL2 binds tumor protein D52 (TPD52), which is frequently overexpressed in ovarian carcinoma, but the clinical significance of MAL2 and TPD52 overexpression was unknown. Immunohistochemical analyses of MAL2 and TPD52 expression were performed using tissue microarray sections including benign, borderline and malignant epithelial ovarian tumours. Inmmunohistochemical staining intensity and distribution was assessed both visually and digitally. MAL2 and TPD52 were significantly overexpressed in high-grade serous carcinomas compared with serous borderline tumours. MAL2 expression was highest in serous carcinomas relative to other histological subtypes, whereas TPD52 expression was highest in clear cell carcinomas. MAL2 expression was not related to patient survival, however high-level TPD52 staining was significantly associated with improved overall survival in patients with stage III serous ovarian carcinoma (log-rank test, p < 0.001; n = 124) and was an independent predictor of survival in the overall carcinoma cohort (hazard ratio (HR), 0.498; 95% confidence interval (CI), 0.34-0.728; p < 0.001; n = 221), and in serous carcinomas (HR, 0.440; 95% CI, 0.294-0.658; p < 0.001; n = 182). MAL2 is frequently overexpressed in ovarian carcinoma, and TPD52 overexpression is a favourable independent prognostic marker of potential value in the management of ovarian carcinoma patients

  15. Pathogenicity of Phytophthora austrocedrae on Austrocedrus chilensis and its relation with mal del ciprés in Patagonia

    Science.gov (United States)

    A. G. Greslebin; E. M. Hansen

    2010-01-01

    Field observations, isolations and pathogenicity tests were performed on Austrocedrus chilensis (Cupressaceae) trees to determine the pathogenicity of Phytophthora austrocedrae and its role in the aetiology of the cypress disease mal del ciprés (MDC) in Argentina. It was found that P. austrocedrae...

  16. La Justificación de la Presencia del Mal en el Mundo desde la Estética Agustiniana

    Directory of Open Access Journals (Sweden)

    David Ezequiel Téllez Maqueo

    2016-07-01

    Full Text Available La posibilidad de establecer una conciliación entre Dios como principio absoluto de bondad, y el mal presente en la realidad en sus más diversas manifestaciones (miseria, guerras, enfermedad, ignorancia, etc., ha sido una preocupación constante en la historia del pensamiento occidental. Si Dios existe, ¿cómo puede suceder que exista mal en el mundo? Para dar una respuesta racional satisfactoria se han planteado diversas respuestas. Pero Agustin de Hipona representa la primera teodicea dominante de la historia occidental, por lo que el conocimiento de su postura ante este problema es digno de interés. Para ello, el objetivo de estas líneas es triple: 1 establecer en qué consiste la solución estética de san Agustin al problema del mal, II señalar algunas de las críticas más conocidas que ha recibido en el siglo XX, y III afirmar que la solución agustiniana puede seguir siendo base de una teodicea capaz de hacer compatible la existencia de Dios y el mal en el mundo, tras la valoración de las distintas posturas críticas que ha recibido.

  17. Characterization of recombinant Mal d 4 and its application for component-resolved diagnosis of apple allergy

    NARCIS (Netherlands)

    Ma, Y.; Zuidmeer, L.; Bohle, B.; Bolhaar, S. T. H.; Gadermaier, G.; Gonzalez-Mancebo, E.; Fernandez-Rivas, M.; Knulst, A. C.; Himly, M.; Asero, R.; Ebner, C.; van Ree, R.; Ferreira, F.; Breiteneder, H.; Hoffmann-Sommergruber, K.

    2006-01-01

    BACKGROUND: Profilins are ubiquitous panallergens that have been extensively characterized; yet, their clinical relevance is still unclear. OBJECTIVE: The aim of the present study was to produce recombinant apple profilin (rMal d 4) and to evaluate its allergenic activity and its potency for

  18. A Novel Bifunctional Amino Acid Racemase With Multiple Substrate Specificity, MalY From Lactobacillus sakei LT-13: Genome-Based Identification and Enzymological Characterization

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    Shiro Kato

    2018-03-01

    Full Text Available The Lactobacillus sakei strain LK-145 isolated from Moto, a starter of sake, produces potentially large amounts of three D-amino acids, D-Ala, D-Glu, and D-Asp, in a medium containing amylase-digested rice as a carbon source. The comparison of metabolic pathways deduced from the complete genome sequence of strain LK-145 to the type culture strain of Lactobacillus sakei strain LT-13 showed that the L- and D-amino acid metabolic pathways are similar between the two strains. However, a marked difference was observed in the putative cysteine/methionine metabolic pathways of strain LK-145 and LT-13. The cystathionine β-lyase homolog gene malY was annotated only in the genome of strain LT-13. Cystathionine β-lyase is an important enzyme in the cysteine/methionine metabolic pathway that catalyzes the conversion of L-cystathionine into L-homocysteine. In addition to malY, most genome-sequenced strains of L. sakei including LT-13 lacked the homologous genes encoding other putative enzymes in this pathway. Accordingly, the cysteine/methionine metabolic pathway likely does not function well in almost all strains of L. sakei. We succeeded in cloning and expressing the malY gene from strain LT-13 (Ls-malY in the cells of Escherichia coli BL21 (DE3 and characterized the enzymological properties of Ls-MalY. Spectral analysis of purified Ls-MalY showed that Ls-MalY contained a pyridoxal 5′-phosphate (PLP as a cofactor, and this observation agreed well with the prediction based on its primary structure. Ls-MalY showed amino acid racemase activity and cystathionine β-lyase activity. Ls-MalY showed amino acid racemase activities in various amino acids, such as Ala, Arg, Asn, Glu, Gln, His, Leu, Lys, Met, Ser, Thr, Trp, and Val. Mutational analysis revealed that the -amino group of Lys233 in the primary structure of Ls-MalY likely bound to PLP, and Lys233 was an essential residue for Ls-MalY to catalyze both the amino acid racemase and β-lyase reactions. In

  19. DIREITO DE EXCEÇÃO: OS RISCOS DE UM MAL NECESSÁRIO

    Directory of Open Access Journals (Sweden)

    Mariana Belchior Ribeiro Freire

    2010-08-01

    Full Text Available O presente trabalho tem como escopo analisar o estado de exceção no seu liame entre a manutenção do status quo ante e o salto para a revolução. Sob a óptica dos pensamentos de renomados filósofos (Jean Bodin, Thomas Hobbes, Rosseau, Hans Kelsen e Carl Schmitt, procuramos analisar os benefícios e os riscos da instituição do estado de exceção, tendo em vista que se pode considerar este um mal necessário. O estado de exceção é um avanço nas democracias contemporâneas, como observaremos a sua previsão importa uma segurança à sociedade de que é possível mudar preservando alguns direitos constitucionais.

  20. Uruguay mining inventory results of the Mal Abrigo aerial photography chemical prospect ion

    International Nuclear Information System (INIS)

    Zeegers, H.; Artignan, D.; Vairon, P.

    1982-01-01

    This report presents the results of the chemical prospecting strategic multielemental carried out, of the mining Inventory framework from the Uruguay aerial photography Mal Abrigo (sector M 25, area 82). The covered surface is of 660 km with a total of 753 samples, corresponding to an approximate sampling density of 1.14 samples for krri2; in parallel pH measures and radioactivity were made. The samples were analyzed in the laboratories of the BRGM (Orleans), for 22 elements for Spectrometry of Emission Captures. The geochemical answer in connection with the litology was good. Sixteen anomalies, little contrasted has been retained in what concerns to the elements Pb, Zn, Cu, Ace, Ag, and W; eight of those which are constituted for regrouping points. The main purpose has been to search ultramafic rocs in Cerro Chato -Durazno province.

  1. SmartMal: A Service-Oriented Behavioral Malware Detection Framework for Mobile Devices

    Directory of Open Access Journals (Sweden)

    Chao Wang

    2014-01-01

    Full Text Available This paper presents SmartMal—a novel service-oriented behavioral malware detection framework for vehicular and mobile devices. The highlight of SmartMal is to introduce service-oriented architecture (SOA concepts and behavior analysis into the malware detection paradigms. The proposed framework relies on client-server architecture, the client continuously extracts various features and transfers them to the server, and the server’s main task is to detect anomalies using state-of-art detection algorithms. Multiple distributed servers simultaneously analyze the feature vector using various detectors and information fusion is used to concatenate the results of detectors. We also propose a cycle-based statistical approach for mobile device anomaly detection. We accomplish this by analyzing the users’ regular usage patterns. Empirical results suggest that the proposed framework and novel anomaly detection algorithm are highly effective in detecting malware on Android devices.

  2. Mal de Debarquement Syndrome: A Rare Entity—A Case Report and Review of the Literature

    Directory of Open Access Journals (Sweden)

    Veronica Nwagwu

    2015-01-01

    Full Text Available Mal de Debarquement Syndrome (MDS is a rare, understudied, underdiagnosed, and self-limiting condition. Etiology and incidence are unknown. It is characterized by abnormal sensation of motion/balance reported after travel by air, land, and sea; being reexposed to motion/activity relieves it. Symptoms may last from minutes to years. Workup though required reveals no findings; it is a diagnosis of exclusion. While no efficacious treatment exists, amitriptyline and benzodiazepines as well as supportive therapy have proved to be useful. We have described a 40-year-old Caucasian female who presented for the evaluation of persistent rocking and swaying sensation after a ship cruise which lasted for one week. Patient was treated with benzodiazepines after extensive workup and is now stable. A high index of suspicion is required to make a diagnosis.

  3. malERA: An updated research agenda for malaria elimination and eradication.

    Science.gov (United States)

    Rabinovich, Regina N; Drakeley, Chris; Djimde, Abdoulaye A; Hall, B Fenton; Hay, Simon I; Hemingway, Janet; Kaslow, David C; Noor, Abdisalan; Okumu, Fredros; Steketee, Richard; Tanner, Marcel; Wells, Timothy N C; Whittaker, Maxine A; Winzeler, Elizabeth A; Wirth, Dyann F; Whitfield, Kate; Alonso, Pedro L

    2017-11-01

    Achieving a malaria-free world presents exciting scientific challenges as well as overwhelming health, equity, and economic benefits. WHO and countries are setting ambitious goals for reducing the burden and eliminating malaria through the "Global Technical Strategy" and 21 countries are aiming to eliminate malaria by 2020. The commitment to achieve these targets should be celebrated. However, the need for innovation to achieve these goals, sustain elimination, and free the world of malaria is greater than ever. Over 180 experts across multiple disciplines are engaged in the Malaria Eradication Research Agenda (malERA) Refresh process to address problems that need to be solved. The result is a research and development agenda to accelerate malaria elimination and, in the longer term, transform the malaria community's ability to eradicate it globally.

  4. malERA: An updated research agenda for malaria elimination and eradication.

    Directory of Open Access Journals (Sweden)

    Regina N Rabinovich

    2017-11-01

    Full Text Available Achieving a malaria-free world presents exciting scientific challenges as well as overwhelming health, equity, and economic benefits. WHO and countries are setting ambitious goals for reducing the burden and eliminating malaria through the "Global Technical Strategy" and 21 countries are aiming to eliminate malaria by 2020. The commitment to achieve these targets should be celebrated. However, the need for innovation to achieve these goals, sustain elimination, and free the world of malaria is greater than ever. Over 180 experts across multiple disciplines are engaged in the Malaria Eradication Research Agenda (malERA Refresh process to address problems that need to be solved. The result is a research and development agenda to accelerate malaria elimination and, in the longer term, transform the malaria community's ability to eradicate it globally.

  5. ACCUMULATION OF POLYHYDROXYALKANOIC ACIDS BY AZOTOBACTER CHROOCOCCUM MAL-201 FROM ORGANIC WASTE

    Directory of Open Access Journals (Sweden)

    Soma Pal Saha

    2013-08-01

    Full Text Available Azotobacter chroococcum MAL-201 (MTCC 3853, a free-living nitrogen-fixing bacterium accumulated intracellular poly(3-hydroxybutyric acid [P(3HB] accounting 69% of cell dry weight (CDW when grown in nitrogrn-free Stockdale medium containing 2% (w/v glucose. It also produced copolymer of poly(3-hydroxybutyrate co-3-hydroxyvalerate [P(3HB-co-3HV] using glucose as primary carbon source and valerate cas cosubstrate. To make the polymer production cost effective four types of waste material of different origin were tested for growth and polymer production. Stockdale medium supplemented with 1% (w/v waste materials failed to yield good growth and polymer accumulation. Two–step cultivation was adopted for better growth and enhanced polymer accumulation. The candy factory waste was most suitable for synthesis of P(3HB accounting 17.8 and 40.58% using single and two-step cultivation conditions respectively. Wastes of domestic and poultry origin produced P(3HB-co-3HV with 3HV content 28.8 and 21.5 mol% respectively in two-step cultivation. Increase concentration of these wastes resulted in further upliftment of 3HV content of polymer with reduced growth and polymer accumulation. However, at optimum incubation the strain MAL-201 cells accumulated P(3HB 48.5% of CDW (at 40h from candy factory waste and P(3HB-co-3HV 24.75 % of CDW with 3HV 34.65 mol % from domestic waste. Intrinsic viscosity, molecular weight and thermal degradation of the polymers accumulated in the cells grown in glucose, glucose with valerate and glucose with waste were compared.

  6. MAL Overexpression Leads to Disturbed Expression of Genes That Influence Cytoskeletal Organization and Differentiation of Schwann Cells

    Directory of Open Access Journals (Sweden)

    Daniela Schmid

    2014-09-01

    Full Text Available In the developing peripheral nervous system, a coordinated reciprocal signaling between Schwann cells and axons is crucial for accurate myelination. The myelin and lymphocyte protein MAL is a component of lipid rafts that is important for targeting proteins and lipids to distinct domains. MAL overexpression impedes peripheral myelinogenesis, which is evident by a delayed onset of myelination and reduced expression of the myelin protein zero (Mpz/P0 and the low-affinity neurotrophin receptor p75NTR . This study shows that MAL overexpression leads to a significant reduction of Mpz and p75NTR expression in primary mouse Schwann cell cultures, which was already evident before differentiation, implicating an effect of MAL in early Schwann cell development. Their transcription was robustly reduced, despite normal expression of essential transcription factors and receptors. Further, the cAMP response element-binding protein (CREB and phosphoinositide 3-kinase signaling pathways important for Schwann cell differentiation were correctly induced, highlighting that other so far unknown rate limiting factors do exist. We identified novel genes expressed by Schwann cells in a MAL-dependent manner in vivo and in vitro. A number of those, including S100a4, RhoU and Krt23, are implicated in cytoskeletal organization and plasma membrane dynamics. We showed that S100a4 is predominantly expressed by nonmyelinating Schwann cells, whereas RhoU was localized within myelin membranes, and Krt23 was detected in nonmyelinating as well as in myelinating Schwann cells. Their differential expression during early peripheral nerve development further underlines their possible role in influencing Schwann cell differentiation and myelination.

  7. El mal de ojo y su relación con el marasmo y kwashiorkor: El caso de las madres de Turbo, Antioquia, Colombia Mal de ojo and its relationship with marasm and kwashiorkor: the Turbo mother’s case

    Directory of Open Access Journals (Sweden)

    Gildardo Uribe Gil

    2007-03-01

    Full Text Available Objetivo: Describir las percepciones y prácticas socio-culturales de las madres frente al proceso de desnutrición aguda grave de los niños: marasmo y kwashiorkor. Metodología: Etnografía descriptiva. Se realizaron 20 entrevistas semiestructuradas, 2 entrevistas grupales y observación en los hogares y en el hospital. El análisis se realizó manualmente. Resultados: Las madres perciben la desnutrición aguda grave como una consecuencia del mal de ojo, el cual afecta a los niños menores de 7 años. El mal de ojo se clasifica como "ojo secador" y "ojo de la calle". Para las madres, el ojo secador enmagrece totalmente a los niños, lo cual podríamos asimilar al marasmo. No es claro si el ojo de la calle conlleva al kwashiorkor, pero es claro que el kwashirkor es causado por el mal de ojo. Los médicos tradicionales, como los rezanderos, ocupan un lugar importante en el tratamiento de las enfermedades de filiación cultural. Conclusiones: En el modelo biomédico no existen ni el mal de ojo ni la desnutrición como enfermedad. La desnutrición se conceptúa como estado y finalmente se objetiviza en cifras estadísticas, lo cual dificulta la atención integral de los niños. El estudio devela un mundo desconocido por el sistema biomédico, y un mundo de prácticas culturales frente al proceso de desnutrición, que adecuadamente valoradas permitirían mejorar la atención integral y evitar la muerte infantil por desnutrición aguda grave o por el mal de ojo.Objective: To describe perceptions and socio- cultural practices by the mothers facing severe malnutrition in children: Marasm and Kwashiorkor. Methodology: Descriptive ethnography. Twenty semi-structured interviews and two tribal ones were carried. Homes and hospitalized children were observed. Analysis was manually performed. Results: Mother perceives severe malnutrition like "mal de ojo" consequence afflicting children under seven. Mal de ojo is classified as "drying-eye" or as "street

  8. Ação do radium sôbre o vírus da Coriomeningite linfocitária benigna Radium effect upon the lymphocytic choriomeningitis virus

    Directory of Open Access Journals (Sweden)

    J. Guilherme Lacorte

    1968-01-01

    Full Text Available O presente trabalho faz parte de uma seqüência iniciada em 1953 com a verificação do efeito dos raios X sôbre o vírus da gripe em que observamos que os mesmos, em doses fracas, tem aumentado o seu poder patogênico para camundongos. Posteriormente, verificamos a ação do radium sôbre o vírus da gripe e da poliomielite. Neste último caso, o vírus irradiado mostrou-se ativo durante maior número de dias. Nas pesquisas aqui referidas, submetemos o vírus da coriomeningite linfocitária benigna a ação do radium, usando quatro agulhas de 1 mg desse elemento em dispositivo que idealizamos para êste fim. Depois de irradiada, foi a suspensão de vírus diluida a 10*-1, 10*-2 e 10*-3 para as inoculações em camundongos, juntamente com as diluições testemunhas. Observamos que o vírus resistiu pelo menos 264 dias, à temperatura de 4ºC. Quanto às alterações do poder patogênico provocadas pelo radium verificamos que o mesmo não se altera após 24 horas de irradiação. Diminue após 8 dias para aumentar, de modo seguro, após 20 e 33 dias. Iguala-se ao testemunha depois de 78 dias.In the present paper the authors refered the experiments made with the lymphocytic chriomeningitis virus. We strain, after exposition to 4 tubes of 1 mg of radium. The virus suspension was put into the Carrel flask in a layer of 0,1 cm. The titrations of the irradiated virus suspension were made after 24 hours, 8, 20, 33, 78, 85, 120, 264, 292, 387 and 535 days. the virus was still active after 264 days, not after 292 days. The virus irradiated during 24 hours presented the same pathogenicity form mice than the control but after 8 days it was lesser and after 20 and 33 days it was enchanced (Graphic 10. After 78 days the pathogenic power was the same for the irradiated virus and the control.

  9. Influencia del tratamiento quirúrgico de la próstata sobre la función renal en pacientes con insuficiencia renal crónica secundaria a hiperplasia prostática benigna

    Directory of Open Access Journals (Sweden)

    Roxana Aguirre Castañeda

    2002-07-01

    Full Text Available Objetivo: Evaluar la influencia del tratamiento quirúrgico sobre la función renal en pacientes con Insuficiencia Renal Crónica (IRC causada por Hiperplasia Prostática Benigna (HPB. Material y métodos: Es un estudio descriptivo, retrospectivo y analítico de series de casos; cuya variable resultado principal fue el delta de creatinina (creatinina post cirugía - creatinina pre-cirugía, los deltas de creatinina negativos se categorizaron como mejoría de la función renal y los deltas de creatinina positivos como deterioro de la función renal. Resultados: De 40 casos, 24 cumplían con los criterios de inclusión. La edad promedio fue de 67.2 ± 6.8 años. El síntoma más frecuente fue el chorro urinario delgado presentándose en 20 (83.3% pacientes. Trece(54.17% pacientes tuvieron una próstata mediana, quienes con los pacientes de próstata grande refirieron con mayor frecuencia el síntoma de polaquiuria (p=0.03. El tratamiento quirúrgico de pacientes con IRC por HPB produjo una mejoría de la función renal en el 83% de los casos. Solo 4(16.67% pacientes tuvieron delta de creatinina positivo con disminución de la función renal post-cirugía. Se encontró una correlación directa entre la edad y el delta de creatinina (r=0.55 (p=0.004 traduciendo una asociación del deterioro de la función renal post-cirugía con la edad. Conclusiones: El tratamiento quirúrgico de pacientes con IRC por HPB produjo una mejoría de la función renal en la mayoría de los pacientes evaluados en este estudio. No se identificó factores de riesgo relacionados con un deterioro o mejoría de la función renal post-cirugía. (Rev Med Hered 2002; 13: 99-104.

  10. A intervenção fonoaudiológica no pós-operatório da hipertrofia benigna do músculo masseter The miofunctional oral intervention in the surgery treatment for the masseter muscle hipertrophy

    Directory of Open Access Journals (Sweden)

    Laura Davison Mangilli

    2006-04-01

    Full Text Available OBJETIVO: descrever a abordagem fonoaudiológica no pós-operatório de pacientes que realizaram correção cirúrgica da hipertrofia do músculo masseter. METODOLOGIA: foram coletados dados referentes à avaliação e ao tratamento fonoaudiológico de 4 prontuários de sujeitos de ambos os gêneros, com faixa etária entre 16 e 24 anos, com hipertrofia benigna do músculo masseter, tratados cirurgicamente. RESULTADOS: as principais queixas pós-cirúrgicas estiveram relacionadas à limitação da abertura da boca, à dor na região da cirurgia, à rigidez muscular e a estalo em região da ATM. A terapia fonoaudiológica baseou-se em orientação quanto à retirada de hábitos deletérios; termoterapia na região do músculo masseter; manipulação da musculatura envolvida extra e intrabucais; alongamento da musculatura facial e cervical; alavanca de abertura forçada de boca e exercícios de órgãos fonoarticulatórios. CONCLUSÕES: a terapia fonoaudiológica apresenta-se como uma possibilidade de complementação ao tratamento cirúrgico, na adequação da amplitude dos movimentos mandibulares, assim como na eliminação dos sintomas presentes no pós-cirúrgico e na conscientização dos hábitos deletérios, que são apontados pela literatura como possíveis fatores desencadeantes.AIM: the aim of this study was to describe miofunctional oral intervention in patients with Masseter muscle hipertrophy treated by surgery. METHODS: the sample consisted of 4 patients, male and female, with ages between 16 and 24 years, with Masseter muscle hipertrophy treated by surgery. RESULTS: the main complains on the postoperative were related to trismus, muscle rigidity, and clicking in the temporomandibular joint. The myofunctional oral therapy was based on orientation in the abnormal habits (bruxism, clenching elimination, hyperthermia induced in the masseter muscle, oral muscles massage, facial and cervical muscles stretching, miofunctional exercises and

  11. Aspectos clínicos e funcionais do equilíbrio corporal em idosos com vertigem posicional paroxística benigna Clinical and functional aspects of body balance in elderly subjects with benign paroxysmal positional vertigo

    Directory of Open Access Journals (Sweden)

    Daniela Patricia Vaz

    2013-04-01

    Full Text Available Vertigem Posicional Paroxística Benigna (VPPB pode alterar o equilíbrio corporal em pacientes idosos. OBJETIVO: Observar os efeitos da manobra de Epley em idosos com VPPB, avaliando os aspectos clínicos e funcionais do equilíbrio corporal. Forma de estudo: clínico e prospectivo. MÉTODO: Após o diagnóstico da doença (teste de DixHallpike, os testes Time Up and Go (TUGT, Clinical test of Sensory Interaction and Balance (CTSIB e o teste de membros inferiores (MMI foram realizados antes e após a manobra de reposicionamento de Epley modificada. RESULTADOS: O gênero feminino foi o mais prevalente e a média etária foi de 70,10 anos (DP = 7,00. Todos os pacientes apresentaram ductolitíase de canal posterior. Os seguintes sintomas melhoraram após a manobra: a instabilidade postural (p = 0,006, náusea e vômito (p = 0,021 e zumbido (p = 0,003. Em relação ao TUGT e o escore do teste de MMII, observou-se diminuição significante do tempo pós-manobra de Epley (p Benign paroxysmal positional vertigo (BPPV may compromise the balance of elderly subjects. OBJECTIVE: To observe the effects of the Epley maneuver in elderly subjects with BPPV and assess clinical and functional aspects of body balance. METHOD: This is a prospective clinical study. Patients diagnosed with BPPV (Dix-Hallpike test were submitted to the Timed Up & Go (TUG test, the Clinical Test of Sensory Interaction and Balance (CTSIB, and lower limb testing before and after they were repositioned using the modified Epley maneuver. RESULTS: Most subjects were females, and the group's mean age was 70.10 years (SD = 7.00. All patients had canalithiasis of the posterior canal. The following symptoms improved after the maneuver: postural instability (p = 0.006, nausea and vomiting (p = 0.021, and tinnitus (p = 0.003. Subjects improved their times significantly in the TUG and lower limb tests after the Epley maneuver (p < 0.001. Patients performed better on the CTSIB after the Epley

  12. Le problème du mal dans le Guide des Perplexes et son arrière-plan talmudique

    Directory of Open Access Journals (Sweden)

    Costa, José

    2010-12-01

    Full Text Available At first sight, the question of evil is regarded in the Guide for the Perplexed in a paradoxical manner. Thus, in Guide I, 2, Maimonides examines the notions of good and evil as subjective evaluations possessing neither the rigour not the exactness of the notions of true and false. However, the question of evil occupies an essential place in the Guide, as various modern authors have shown. This question is important to Maimonides because he is, in this respect, the heir of the rabbinic tradition and his conception of evil is largely based on an interaction with the Talmudic and Midrašic texts. Therefore, we would like to review thirty-nine rabbinic ‘quotes’ which appear in chapters 8 to 24 in the third part of the Guide and deal with the origin of evil, the meaning of suffering and the evil inclination. Maimonides reappropriates the midrašim that are susceptible of being in agreement with his rationalist positions and also quotes some rabbinic traditions that are too close to mu ͑tazilism, undoubtedly aware of the more profound resemblance that exists between the rabbinic and mu ͑tazilite doctrines of evil and retribution.A primera vista, el problema del mal es abordado en la Guía de Perplejos de manera paradójica. Para Maimónides, las nociones de bien y mal son subjetivas y no resultan ni rigorosas ni exactas, a la inversa de las nociones de verdad y falsedad (Guía I, 2. Sin embargo, el problema del mal es muy importante en la Guía, como lo demostraran varios autores. Maimónides es el heredero de la tradición rabínica y existe en la Guía una interacción entre la filosofia de Maimónides y los textos talmúdicos y midrásicos. Es particularmente el caso de las treinta y nueve citas rabínicas de la Guía II, 8-24, que tratan del origen del mal, del significado del sufrimiento y de la inclinación al mal. Maimónides cita los midrašim que concuerdan con sus posiciones racionalistas y evoca también algunas tradiciones rab

  13. Epilepsia"Petit Mal" aspectos clínicos, eletrencefalográficos e evolutivos

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    Paulo Pinto Pupo

    1961-01-01

    Full Text Available In the past few years somewhat new yet often differing points of view have been affirmed refering to Petit Mal epilepsy, with regard to its clinical, eletrencephalographic and evolutive aspects. The classical concept of PM epilepsy as established by Lennox and Gibbs, with its well defined clinical and EEGraphic characteristics is continually being modified with new research work on clinical and EEGraphic aspects. Numerous clinical cases have been published whose evolution clashes with that classically described and likewise numerous are those cases where the EEG shows signs of focal electric activity besides spike and wave dis-rythmia. Cases have been known where surgical exerese on the focus causes temporary desappearance of the spike and wave disrythmia. The present concept now holding sway is that PM epilepsy is a kind of reaction of infantile encephalon to diverse harmful causes. From this it will be seen we are very far from the concept that PM epilepsy is a pure form of idiopathic epilepsy. For these reasons we decided to re-examine those cases observed between 1950 and 1960. With this in mind we chose 141 PM epilepsy cases, from among over 23000 epileptics, all examined under a standard criterion by a small group of senior assistants. All cases suspected of Psm epilepsy were excluded. The analysis of this group of patients was compared to that of another group with GM as well as PM seizures (104 patients; in 52 of these cases, studies were made concerning the evolutive, clinical and EEGra-phic aspects. METHOD: Clinical criterion was used for selection of the cases. The results of the analysis from the clinical and EEGraphic point of view were exhibited in demonstrative graphs. From the clinical point of view we strove to find out positive hereditary elements, organic cerebral injury factor (intellectual deficit, mood and behaviour disturbances, neurologic or somatic signs, as well as other development anomalies, the presence of febrile

  14. Hypothesis: The Vestibular and Cerebellar Basis of the Mal de Debarquement Syndrome

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    Bernard Cohen

    2018-02-01

    Full Text Available The Mal de Debarquement syndrome (MdDS generally follows sea voyages, but it can occur after turbulent flights or spontaneously. The primary features are objective or perceived continuous rocking, swaying, and/or bobbing at 0.2 Hz after sea voyages or 0.3 Hz after flights. The oscillations can continue for months or years and are immensely disturbing. Associated symptoms appear to be secondary to the incessant sensation of movement. We previously suggested that the illness can be attributed to maladaptation of the velocity storage integrator in the vestibular system, but the actual neural mechanisms driving the MdDS are unknown. Here, based on experiments in subhuman primates, we propose a series of postulates through which the MdDS is generated: (1 The MdDS is produced in the velocity storage integrator by activation of vestibular-only (VO neurons on either side of the brainstem that are oscillating back and forth at 0.2 or 0.3 Hz. (2 The groups of VO neurons are driven by signals that originate in Purkinje cells in the cerebellar nodulus. (3 Prolonged exposure to roll, either on the sea or in the air, conditions the roll-related neurons in the nodulus. (4 The prolonged exposure causes a shift of the pitch orientation vector from its original position aligned with gravity to a position tilted in roll. (5 Successful treatment involves exposure to a full-field optokinetic stimulus rotating around the spatial vertical countering the direction of the vestibular imbalance. This is done while rolling the head at the frequency of the perceived rocking, swaying, or bobbing. We also note experiments that could be used to verify these postulates, as well as considering potential flaws in the logic. Important unanswered questions: (1 Why does the MdDS predominantly affect women? (2 What aspect of roll causes the prolongation of the tilted orientation vector, and why is it so prolonged in some individuals? (3 What produces the increase in symptoms of

  15. Migrações internas e malária urbana - Bahia, Brasil Internal migration and urban malaria - Bahia, Brazil

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    Sebastião Loureiro de Souza

    1986-10-01

    Full Text Available Estuda-se as características sócio-econômicas dos indivíduos acometidos pela malária, em 1983, na área urbana de Camaçari - Bahia, Brasil, com destaque para os subgrupos migrantes e não migrantes. As condições de vida precárias de ambos os subgrupos são apontadas como os determinantes do surto de malária desencadeado no local.It is proposed to study the socio-economic characteristics of individuals who were infected with malaria in the urban area of Camaçari, Bahia, Brazil, in 1983. Special emphasis being given to the subgroups of migrants and nonmigrants. The precarious living conditions of both subgroups are identified as determinative of the malaria outbreak which occurred there.

  16. Analytical Characterization of the Hydrolysis of Barley Malt Macromolecules During Enzymatic Degradation Over Time Using AF4/MALS/RI.

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    Rübsam, Heinrich; Becker, Thomas; Gastl, Martina

    2017-06-01

    The changes on the molecular weight distribution (MWD) and particle size distribution (PSD) during hydrolysis of barley malt in isothermal mashing procedures were determined using asymmetrical flow field flow fractionation coupled to multiangle laser light scattering and refractive index (AF4/MALS/RI). Mash/trials were focused on amylolytic starch degradation. Therefore, temperatures (65, 70, and 75 °C) were selected according to α- and β-amylases range of activity. Samples were produced by triplicate, tracking amylolytic processes over time periods from 10 to 90 min in each mash/trial. AF4/MALS/RI analysis demonstrated significant differences on the values of the MWD and PSD according to the temperature/time profile used. At mashing times over 30 min at a temperature of 65 °C, when α- and β-amylase are both active, the decrease over time of the MWD and PSD was significantly higher (P < 0.005) than at 70 °C when mainly α-amylase is active. At 75 °C, also the activity of α-amylase decreased and the MWD and PSD were significantly lower (P < 0.005) than at 70 or 65 °C at any time of the procedure. The MWD and PSD of beer components influence beer palate fullness, thus AF4/ MALS/RI would be a powerful tool for breweries to adapt their technological processes to obtain beers with particular sensorial attributes. © 2017 Institute of Food Technologists®.

  17. La naturaleza del mal en el pensamiento de Hannah Arendt | The nature of evil in Hannah Arendt’s thinking

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    María Cristina Hermida del Llano

    2016-12-01

    Full Text Available RESUMEN. La cuestión del mal ocupa un lugar central en el pensamiento de Hannah Arendt al constituir un concepto transversal que recorre todos sus trenes de pensamiento. Se somete a análisis la “naturaleza del mal” a través del estudio de su obra y de su propia experiencia vital, especialmente al cubrir el juicio de Eichmann en Jerusalén, donde ella afirmaría que éste representaba “la banalidad del mal”. Se trata de averiguar si en su particular concepción del mal influyó Voltaire, por qué surge el mal, por qué se manifiesta de forma permanente en la historia y si puede ser destruido   ABSTRACT. The topic of evil has a central place in Hannah Arendt’s thinking as it lies at the core of all her trains of thought. We analyze the “nature of evil” in Hannah Arendt’s philosophy through the study of her work and of her life experience, especially when she covered the trial of Eichmann in Jerusalem where she pointed out that Eichmann represented “the banality of evil”. Our goal in this contribution is to understand whether the philosophy of Voltaire could have influenced Arendt’s conception of evil, why it arises, why it persists throughout history, and whether it can be destroyed

  18. Recombinant Mal d 1 facilitates sublingual challenge tests of birch pollen-allergic patients with apple allergy.

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    Kinaciyan, T; Nagl, B; Faustmann, S; Kopp, S; Wolkersdorfer, M; Bohle, B

    2016-02-01

    It is still unclear whether allergen-specific immunotherapy (AIT) with birch pollen improves birch pollen-related food allergy. One reason for this may be the lack of standardized tests to assess clinical reactions to birch pollen-related foods, for example apple. We tested the applicability of recombinant (r) Mal d 1, the Bet v 1-homolog in apple, for oral challenge tests. Increasing concentrations of rMal d 1 in 0.9% NaCl were sublingually administered to 72 birch pollen-allergic patients with apple allergy. The dose of 1.6 μg induced oral allergy syndromes in 26.4%, 3.2 μg in 15.3%, 6.3 μg in 27.8%, 12.5 μg in 8.3%, 25 μg in 11.1%, and 50 μg in 4.2% of the patients. No severe reactions occurred. None of the patients reacted to 0.9% NaCl alone. Sublingual administration of 50 μg of rMal d 1 induced no reactions in three nonallergic individuals. Our approach allows straight forward, dose-defined sublingual challenge tests in a high number of birch pollen-allergic patients that inter alia can be applied to evaluate the therapeutic efficacy of birch pollen AIT on birch pollen-related food allergy. © 2015 The Authors. Allergy Published by John Wiley & Sons Ltd.

  19. Albertet, “En amor trob tantz de mals seignoratges” (BdT 16.13

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    Francesca Sanguineti

    2008-12-01

    Full Text Available The article provides a commentary and a new critical edition of Albertet’s poem “En amor trob tantz de mals seignoratges”, in which the troubadour praises some of the most courtly ladies of his time. The poem can be linked to the genre of the collective eulogy, where the enumerated ladies are praised essentially for political reasons, since the commendation is clearly addressed to the men hidden behind them: famous specimena of this genre are the ‘tournoiements des dames’ by Huon d’Oisy and Richard de Semilli and Raimbaut de Vaqueiras’ “Carros” (BdT 392.32. Albertet’s song starts with a misogynic tone, since the poet declares that celebrating or loving ladies is worthless, given their immoral behaviour, and with a polemic against the strict rules of courtly love. This misogyny, as is further discovered, is a rhetorical device to praise women as well as a tool to renew the genre of the love song from a thematic point of view.

  20. (Mal)nutrition and the new epidemiological trend in a context of development and inequalities.

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    Souza, Nathália Paula de; Lira, Pedro Israel Cabral de; Fontbonne, Annick; Pinto, Fernanda Cristina de Lima; Cesse, Eduarda Ângela Pessoa

    2017-07-01

    The current context of intense social, economic and political transformations has contributed to changes in the health profile of the population and generated discussions about the impact of these changes on the reorganization of society. At the present moment, the increase in non-communicable illnesses and diseases raises major concerns about the paradox of malnutrition and obesity. Based on an in-depth reading and interpretation of texts, documents and databases, this article discusses issues related to nutrition, considering the dimensions of shortages and excesses, the evolution of nutrition over time, and the connection with the new epidemiological trend. We begin with a conceptual characterization, the historical background and the anthropological connections with the guiding theme of the article. We then describe the prevalence, distribution and secular trend of malnutrition and obesity, as well as the temporal relationship with the new epidemiological trend in Brazil within a context of development and inequalities. Finally, we reflect on the issue of (mal)nutrition in post-modernity, the new interests at stake in the health-disease process, as well as international experiences and strategies of partnerships designed to overcome these problems. We conclude by discussing some current advances and challenges in relation to the complexity and speed of contemporary changes.

  1. Decodificando la esencia del mal, o del terror a la muerte del hijo

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    Maximiliano Korstanje

    2011-01-01

    Full Text Available Durante muchos años filósofos y teólogos se han cuestionado sobre la cuestión de la caída. Es innumerable la bibliografía sobre el tema como así también las propias dudas sobre la omnipresencia y sabiduría de un Dios que implícitamente o no permite la presencia del pecado por medio de su propia creación. El mito fundador de querubín Lucifer no sólo simboliza la relación entre el hombre y la traición sino también el amor filial entre el padre y su creación las cuales concilian la negación cultural de la muerte de la progenie o generaciones más jóvenes. Utilizando la teoría antropológica de los dones de M. Mauss, el presente trabajo teórico intentará explicar el origen mítico del mal dentro de la tradición judeo-cristiana como una de las elaboraciones más temidas, la muerte del hijo.

  2. Quema de libros y antitotalitarismo. Manuel Rivas Los libros arden mal y Ray Bradbury Fahrenheit 451

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    Mechthild Albert

    2015-07-01

    Full Text Available El presente artículo se propone comparar dos novelas cuyo común denominador es el compromiso antitotalitario con motivo de la quema de libros considerada como el culmen de la barbarie anticultural, a saber Los libros arden mal (2006 de Manuel Rivas y Fahrenheit 451 (1953 de Ray Bradbury. Partiendo de las reflexiones de Fernando Rodríguez de la Flor en torno al biblioclasmo (2004, el paralelo se centra en los siguientes aspectos: la descripción zoo- y antropomorfizada de los libros en llamas; el biblioclasmo como expresión del totalitarismo, denotando asimismo una relación ambivalente y dialéctica entre cultura y barbarie; los movimientos subversivos dedicados a mantener el culto al libro y la tradición filosófico-literaria; la intertextualidad y el papel destacado de la Biblia en cuanto Libro de los libros. En conclusión se podrá constatar que, a pesar de numerosos puntos en común, en particular su compromiso antitotalitario, ambos autores se distinguen en concreto por su orientación política y el enfoque de su crítica cultural

  3. El mal en las palabras: El hombre tempestad Evil in Words: El hombre tempestad

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    Ángela Uribe Botero

    2009-06-01

    Full Text Available En este trabajo se muestra cómo es posible que el mal pueda estar contenido en cierta forma de hablar. En términos de J. L. Austin, y de la mano de Hannah Arendt, a la luz de un ejemplo tomado de la historia colombiana, se ilustra la fuerza ilocucionaria de ciertas expresiones. El ejemplo está contenido en uno de los discursos más célebres del expresidente colombiano Laureano Gómez Castro. El texto concluye mostrando cómo, con los enunciados que Gómez emite, antes que cumplir las promesas que hace en su discurso o describir una serie de cosas, miente y en tanto hace esto, cambia el mundo en la forma de actuar sobre él con maldad.This text shows how evil can be contained in certain way of speaking. In terms of J. L. Austin, and considering Hannah Arendt, with the help of an example taken from recent Colombian history, it illustrates the ilocucionary force of certain expressions. The example is found in one of the most important speeches of former president Laureano Gómez Castro. The text concludes by showing how, Gómez, rather than maintaining promises that he makes in his speech or describing a series of things, lies, and in so doing, changes the world through his way of evilly acting above it.

  4. Santa Clara de Nanay: the MAL-ED cohort in Peru.

    Science.gov (United States)

    Yori, Pablo Peñataro; Lee, Gwenyth; Olórtegui, Maribel Paredes; Chávez, César Banda; Flores, Julian Torres; Vasquez, Angel Orbe; Burga, Rosa; Pinedo, Silvia Rengifo; Asayag, César Ramal; Black, Robert E; Caulfield, Laura E; Kosek, Margaret

    2014-11-01

    The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) cohort study communities in Peru are located in Loreto province, in a rural area 15 km from the city of Iquitos. This riverine population of approximately 5000 individuals is fairly representative of Loreto. The province lags behind the rest of the country in access to water and sanitation, per capita income, and key health indicators including infant mortality (43.0 vs 16.0 per 1000 nationwide) and under-5 mortality (60.6 vs 21.0 per 1000). Total fertility rates are higher than elsewhere in the country (4.3 vs 2.6). Nationwide, the prevalence of human immunodeficiency virus is estimated at 0.45%, the prevalence of tuberculosis is 117 per 100 000, and the incidence of malaria is 258 per 100 000. Stunting in this community is high, whereas acute undernutrition is relatively uncommon. The population suffers from high rates of diarrheal disease. Prevalent enteric pathogens include Ascaris, Giardia, enterotoxigenic Escherichia coli, Shigella, and Campylobacter. © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  5. Efeito da manobra de Epley na qualidade de vida dos pacientes com vertigem posicional paroxística benigna Effect of Epley's maneuver on the quality of life of paroxismal positional benign vertigo patients

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    Alcione Botelho Pereira

    2010-12-01

    Full Text Available A vertigem produz impactos significativos na qualidade de vida (QV. É necessário mensurar os efeitos das terapêuticas antivertiginosas na QV. OBJETIVO: Investigar o efeito da manobra de reposicionamento na qualidade de vida de pacientes com vertigem posicional paroxística benigna (VPPB. MATERIAL E MÉTODOS: Estudo retrospectivo, através da revisão dos prontuários de 21 pacientes com VPPB atendidos no serviço de Reabilitação Vestibular (RV de uma clínica escola de Belo Horizonte atendidos em 2007-2008. Foram analisados os escores físicos, funcionais e emocionais, pré e pós-terapia de RV com realização de manobras de reposicionamento de Epley, por meio do questionário Dizziness Handicap Inventory (DHI, específico para avaliação da interferência da tontura na QV. RESULTADOS: O intervalo mediano entre as avaliações foi de 21 dias. O número médio de manobras foi 2,3±1,1. A aplicação do DHI mostrou um significante impacto da VPPB na QV dos pacientes em todas as dimensões da vida diária, com os seguintes escores médios pré e pós-terapia: físico (17,5/3,7, funcional (17,3/3,9, emocional (13,2/3,2 e total (48,1/10,9, respectivamente (pQuality of life (QoL is significantly impaired by vertigo. The effect of specific treatments on QoL deserves investigation. AIM: To assess the effect of repositioning maneuvers on the QoL of benign paroxysmal positioning vertigo (BPPV patients. MATERIALS AND METHODS: A retrospective study design consiting of reviews of charts of BPPV patients in a vestibular rehabilitation unit at a teaching institution in Belo Horizonte, MG, Brazil, from 2007 to 2008. Pre- and post-therapy (Epley's repositioning maneuver scores on the physical, functional and emotional dimensions of the Dizziness Handicap Inventory (DHI were analyzed. RESULTS: Twenty-one patients were included, eighteen (86% were females; the average age was 53.2 years. Ten patients presented bilateral BPPV; in eleven it was unilateral

  6. Variáveis reprodutivas e risco para doenças benignas de mama: estudo caso-controle Reproductive variables and risk of benign breast diseases: a case-control study

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    Ellen E. Hardy

    1990-10-01

    Full Text Available Foram estudadas 257 mulheres com diagnóstico de doença benigna de mama (DBM, atestado por anatomopatológico ou citologia, e um controle para cada uma delas. Foram apresentados resultados das possíveis relações entre variáveis reprodutivas e o risco para DBM. Os casos e controles foram comparados levando em conta a idade na menarca e na menopausa, o número de gravidezes, de meses em que amamentaram e de ciclos menstruais ovulatórios, e os antecedentes familiares de câncer de mama. Mostraram influência significativa, em relação às DBM, a nuliparidade, aumentando o risco enquanto a idade de 30 ou mais anos no primeiro parto o reduziu; o número de ciclos ovulatórios, que foi significativamente maior para os casos, e a média de meses de uso de pílula, menor entre as mulheres com DBM. O uso de contraceptivos orais apresentou um efeito protetor apenas quando a duração total do uso foi maior que dois anos. Os resultados não se revelaram novos ou diferentes se comparados com outros estudos, mas confirmam a relativa concordância entre os fatores de risco para DBM e para câncer de mama, ainda que as relações entre esses fatores e as DBM não sejam tão claras como o são para o câncer, e existam também algumas discrepâncias.The purpose of the study was the identification of risk factors for benign breast diseases (BBD; 257 women with BBD diagnosed through pathological anatomy or citology and a matched control for each were studied. Subjects were selected at The State University of Campinas Hospital and at a private clinic. To enter the study cases had to have a first diagnosis of BBD between October 1979 and August 1984. The following BBD were considered: dysplasia, fibroadenoma, cystic disease, papilloma and ductal ectasia. Reproductive variables were studied as risk factors, including menstrual ovulatory cycles. The date on which the BBD was diagnosed was defined as the index date. For controls, data were considered up to when

  7. Simulação no contexto de problemas mal estruturados

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    Antônio Sérgio de Souza

    1994-12-01

    Full Text Available Simulação é atualmente reconhecida como uma poderosa ferramenta no projeto, análise e operação de sistemas produtivos. Apesar dos avanços recentes em linguagens de simulação, interfaces gráficas e geradores de aplicações, simulação ainda é uma técnica cara e pouco eficiente. Discute-se no texto algumas causas deste fato no contexto de problemas mal estruturados, como é o caso de planejamento e controle da produção. Discute-se a necessidade de realização da modelagem conceitual, não apenas como um passo estanque no processo de simulação, mas de forma progressiva e dinâmica, durante todo o ciclo de vida do projeto, servindo como uma interface entre os contextos real e de simulação.Simulation is now recognized as powerful tool in project, analyses and operation of produtive systems. Although the recent advances in simulation languages, graphical interfaces and in generating applications, simulation is still an expensive and not so efficient technique. In this text we dicuss some reasons for this in the context of not well strutured problems, asit is the case of production planning and control. It is also dicussed the necessity of developing the conceptual modeling of the real system, not only as a separated step in the simulation process, but in a progressive and dynamic way, during the project's life cycle as an interface between the real system and simulation.

  8. Effect of play therapy on behavioral problems of mal-adjusted pre-school children

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    Mehdi Khanbani

    2011-01-01

    Full Text Available Objective: The present research was conducted to study the effect of play therapy on reducing behavioral problems of mal-adjusted children (children with oppositional defiant disorder. Method: By using multistage cluster sampling, regions 6, 7, and 8 in Tehran were selected, and among kindergartens of these areas, 3 kindergartens under the support of welfare organization were randomly selected. From pre-school children of these 3 kindergartens, 40 children that could have behavioral disorder according to their teachers and parents complaints, were carefully tested, and among them, by the results obtained from child symptom inventory questionnaire (CSI-4, teacher's form, and a researcher-made self-control checklist, 16 children who showed severe symptoms of oppositional defiant disorder were selected, and they were randomly divided into control and experimental group. This research is quasi-experimental, and is done by the use of pre-test, post-test, and control group. Results: values of calculated F for oppositional defiant disorder in control and experimental group is meaningful after fixing the effect of pre-test (F(1,12=74/94, P<0/001 so there is a meaningful difference between means of disobedience disorder post-test scores in experimental and control group by having the fixed effect of pre-test effect. Comparison of adjusted means of 2 groups shows that the mean of attention-deficit hyperactivity disorder (ADHD in experimental group (M=14/09 is lower than control group (M=36/66. Therefore, applying play therapy in experimental group in comparison with control group, who did not receive these instructions, caused reduction in attention-deficit hyperactivity disorder (ADHD in pre-school children. Conclusion: Results of this research show that the children's disobedience is reduced by benefiting from play therapy.

  9. Comparison of measles complications in well nourished and mal-nourished children

    International Nuclear Information System (INIS)

    Qaisar, I.; Ahmad, A.; Ahmad, A.

    2009-01-01

    Measles is the most common and the most infectious of the viral infections of childhood. It can cause severe pneumonia, diarrhoea, encephalitis, and death. A significant proportion of deaths due to measles in young children worldwide are attributable to low weight for age. To compare the measles complications in well-nourished and mal-nourished children, this cross-sectional study was conducted at Paediatric out-patient department and paediatric unit 1 Bahawal Victoria Hospital Bahawalpur. Total 120 patients were included in the study. All patients presented with signs and symptoms suggestive of measles according to WHO criteria. These patients were divided into well nourished and malnourished according to the modified Gomez classification. Both groups were evaluated for measles complications like pneumonia, diarrhoea, encephalitis, corneal ulceration, thrombocytopenia, otitis media and myocarditis by detailed history and complete physical examination, and statistically analysed. In the studied patients, 75 were males and 45 were females. Mean age was 23 months. Fifty-nine (49.2%) patients were well-nourished and 61 (50.8%) were undernourished. Fifty-two (43.3%) patients were having pneumonia. Fifty-three (44.2%) patients were having diarrhoea. Twenty-six (21.7%) patients were having encephalitis. Corneal ulceration was found in 9 (7.5%) patients. Thrombocytopenia and otitis media was present in 1 patient in each group. Fourteen patients expired. Measles is a global epidemic problem having many serious complications, including pneumonia, diarrhoea, encephalitis, corneal ulcerations etc. Moreover these complications are more frequent in under nourished children. Efforts should be made to improve the nutritional status of the children and to eradicate this disease by effective vaccination. (author)

  10. Early childhood growth and cognitive outcomes: Findings from the MAL-ED study.

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    Scharf, Rebecca J; Rogawski, Elizabeth T; Murray-Kolb, Laura E; Maphula, Angelina; Svensen, Erling; Tofail, Fahmida; Rasheed, Muneera; Abreu, Claudia; Vasquez, Angel Orbe; Shrestha, Rita; Pendergast, Laura; Mduma, Estomih; Koshy, Beena; Conaway, Mark R; Platts-Mills, James A; Guerrant, Richard L; DeBoer, Mark D

    2018-02-02

    Although many studies around the world hope to measure or improve developmental progress in children to promote community flourishing and productivity, growth is sometimes used as a surrogate because cognitive skills are more difficult to measure. Our objective was to assess how childhood measures of anthropometry correlate with measures of child development in low-income settings with high prevalence of poor nutrition and enteric disease, to inform studies considering growth outcomes in the absence of direct child developmental skill assessment. Children from the MAL-ED study were followed from birth to 24 months of age in field sites in 8 low- and middle-income countries across 3 continents. Monthly weight, length, and head circumference measurements were performed. At 24 months, the Bayley Scales of Infant and Toddler Development was administered. We correlated cognitive measures at 24 months with anthropometric measurements from birth to 2 years comparing 3 constructs: absolute attained monthly measures, summative difference in measures from the mean growth curve, and rate of change in measures. Growth faltering at multiple time periods is related to Bayley cognitive outcomes at 24 months. Birthweight, overall growth by 18-24 months, and rate of growth in the 6- to 18-month period were most associated with 24-month developmental scores. In this study, head circumference measurements, compared with length, was more closely linked to cognitive scores at 24 months. Notably, all studies between growth and cognitive outcomes exhibited low r 2 values (0.001-0.049). Anthropometric measures, particularly head circumference, were related to cognitive development, although explaining a low percent of variance. When feasible, direct measures of child development may be more useful. © 2018 John Wiley & Sons Ltd.

  11. MalHaploFreq: A computer programme for estimating malaria haplotype frequencies from blood samples

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    Smith Thomas A

    2008-07-01

    Full Text Available Abstract Background Molecular markers, particularly those associated with drug resistance, are important surveillance tools that can inform policy choice. People infected with falciparum malaria often contain several genetically-distinct clones of the parasite; genotyping the patients' blood reveals whether or not the marker is present (i.e. its prevalence, but does not reveal its frequency. For example a person with four malaria clones may contain both mutant and wildtype forms of a marker but it is not possible to distinguish the relative frequencies of the mutant and wildtypes i.e. 1:3, 2:2 or 3:1. Methods An appropriate method for obtaining frequencies from prevalence data is by Maximum Likelihood analysis. A computer programme has been developed that allows the frequency of markers, and haplotypes defined by up to three codons, to be estimated from blood phenotype data. Results The programme has been fully documented [see Additional File 1] and provided with a user-friendly interface suitable for large scale analyses. It returns accurate frequencies and 95% confidence intervals from simulated dataset sets and has been extensively tested on field data sets. Additional File 1 User manual for MalHaploFreq. Click here for file Conclusion The programme is included [see Additional File 2] and/or may be freely downloaded from 1. It can then be used to extract molecular marker and haplotype frequencies from their prevalence in human blood samples. This should enhance the use of frequency data to inform antimalarial drug policy choice. Additional File 2 executable programme compiled for use on DOS or windows Click here for file

  12. Comprometimento pulmonar na malária (revisão Pulmonary involvement in malaria

    Directory of Open Access Journals (Sweden)

    Marcos Boulos

    1993-02-01

    Full Text Available Com uma incidência de 3 a 10% dos casos e letalidade próxima a 70%, o comprometimento pulmonar constitui uma das manifestações mais graves da malária por Plasmodium falciparum. Embora sua patogênese não esteja perfeitamente esclarecida, reconhece-se que a hiperativação do sistema imune por antígenos liberados pelo Plasmodium falciparum desempenhe um importante papel no desencadeamento e agravamento das lesões. A estrutura alvo parece ser o endotélio capilar, responsável pelo fluxo de líquidos para o espaço intersticial. Essas células são ativadas por ação de citocinas, produzidas por linfócitos e macrófagos durante a resposta imune, e passam a expressar em sua membrana celular receptores e moléculas de aderência que facilitam a sequestração de eritrócitos parasitados e também a aderência de células capazes de produzir mediadores inflamatórios. A reação inflamatória e a lesão endotelial que se seguem, juntamente com as alterações hemodinâmicas induzidas pelo bloqueio capilar devido ao acúmulo local de eritrócitos e células inflamatórias causam alterações de permeabilidade vascular e, consequentemente, acúmulo de líquido nos espaços intersticiais e alvéolos. Nos casos mais graves, as manifestações clínicas assemelham-se às do quadro da Síndrome do desconforto respiratório do adulto. Comprometimento pulmonar grave pode se instalar rapidamente em qualquer estágio da evolução clínica da malária, mesmo após a cura parasitológica, desconhecendo-se os fatores desencadeantes. Hiperparasitismo, insuficiência renal e gravidez constituem fatores predisponentes. O prognóstico dependerá da rapidez com que o diagnóstico for estabelecido e o correto tratamento instituído. Além do tratamento instituído contra o parasita, especial atenção deverá ser dispensada à monitorização hemodinâmica, se possível através de cateter de Swan-Ganz, à manutenção de adequada oxigenação e balanço h

  13. Isolation of Mal d 1 and Api g 1 - specific recombinant antibodies from mouse IgG Fab fragment libraries - Mal d 1-specific antibody exhibits cross-reactivity against Bet v 1.

    Science.gov (United States)

    Haka, Jaana; Niemi, Merja H; Iljin, Kristiina; Reddy, Vanga Siva; Takkinen, Kristiina; Laukkanen, Marja-Leena

    2015-05-27

    Around 3-5% of the population suffer from IgE-mediated food allergies in Western countries and the number of food-allergenic people is increasing. Individuals with certain pollen allergies may also suffer from a sensitisation to proteins in the food products. As an example a person sensitised to the major birch pollen allergen, Bet v 1, is often sensitised to its homologues, such as the major allergens of apple, Mal d 1, and celery, Api g 1, as well. Development of tools for the reliable, sensitive and quick detection of allergens present in various food products is essential for allergic persons to prevent the consumption of substances causing mild and even life-threatening immune responses. The use of monoclonal antibodies would ensure the specific detection of the harmful food content for a sensitised person. Mouse IgG antibody libraries were constructed from immunised mice and specific recombinant antibodies for Mal d 1 and Api g 1 were isolated from the libraries by phage display. More detailed characterisation of the resulting antibodies was carried out using ELISA, SPR experiments and immunoprecipitation assays. The allergen-specific Fab fragments exhibited high affinity towards the target recombinant allergens. Furthermore, the Fab fragments also recognised native allergens from natural sources. Interestingly, isolated Mal d 1-specific antibody bound also to Bet v 1, the main allergen eliciting the cross-reactivity syndrome between the birch pollen and apple. Despite the similarities in Api g 1 and Bet v 1 tertiary structures, the isolated Api g 1-specific antibodies showed no cross-reactivity to Bet v 1. Here, high-affinity allergen-specific recombinant antibodies were isolated with interesting binding properties. With further development, these antibodies can be utilised as tools for the specific and reliable detection of allergens from different consumable products. This study gives new preliminary insights to elucidate the mechanism behind the pollen

  14. Brucella TIR-like protein TcpB/Btp1 specifically targets the host adaptor protein MAL/TIRAP to promote infection.

    Science.gov (United States)

    Li, Wenna; Ke, Yuehua; Wang, Yufei; Yang, Mingjuan; Gao, Junguang; Zhan, Shaoxia; Xinying, Du; Huang, Liuyu; Li, Wenfeng; Chen, Zeliang; Li, Juan

    2016-08-26

    Brucella spp. are known to avoid host immune recognition and weaken the immune response to infection. Brucella like accomplish this by employing two clever strategies, called the stealth strategy and hijacking strategy. The TIR domain-containing protein (TcpB/Btp1) of Brucella melitensis is thought to be involved in inhibiting host NF-κB activation by binding to adaptors downstream of Toll-like receptors. However, of the five TIR domain-containing adaptors conserved in mammals, whether MyD88 or MAL, even other three adaptors, are specifically targeted by TcpB has not been identified. Here, we confirmed the effect of TcpB on B.melitensis virulence in mice and found that TcpB selectively targets MAL. By using siRNA against MAL, we found that TcpB from B.melitensis is involved in intracellular survival and that MAL affects intracellular replication of B.melitensis. Our results confirm that TcpB specifically targets MAL/TIRAP to disrupt downstream signaling pathways and promote intra-host survival of Brucella spp. Copyright © 2016 Elsevier Inc. All rights reserved.

  15. Situação da malária na tríplice fronteira entre Brasil, Colômbia e Peru

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    Paulo César Peiter

    2013-12-01

    Full Text Available O objetivo deste artigo é analisar a situação da vigilância da malária na tríplice fronteira entre Brasil, Colômbia e Peru. É um estudo qualitativo com aplicação de questionários em cidades da fronteira realizado em 2011. Os resultados foram analisados pela metodologia DOFA e apontaram diferenças significativas entre os sistemas de vigilância da malária na fronteira. Observou-se como debilidades a desarticulação entre atores responsáveis, a insuficiência de pessoal treinado, a alta rotatividade das equipes e a falta de médicos especialistas em malária nos hospitais locais. Verificou-se ainda o desconhecimento sobre a malária e suas formas de prevenção na população entrevistada. As fortalezas são a inserção de novos atores institucionais, a melhora da qualificação profissional, a distribuição de mosquiteiros impregnados e possibilidades de complementaridade entre os sistemas de vigilância a serem aproveitadas pela cooperação entre as equipes de saúde da fronteira, pois o controle da malária só pode ter sucesso tomando-se esta região em seu conjunto.

  16. A formação humana e a incapacidade de pensar: considerações sobre o problema do mal em Hannah Arendt

    Directory of Open Access Journals (Sweden)

    Marcos Alexandre Alves

    2017-08-01

    Full Text Available Este artigo pretende apresentar o tema da formação humana conectado à incapacidade de pensar, tecendo considerações sobre o problema do mal no pensamento de Hannah Arendt. A autora é conhecida como pensadora da política que concentrou atenção especial ao problema do mal que assolou o mundo na primeira metade do século XX. A partir da análise de Origens do Totalitarismo, de 1951, e de Eichmann em Jerusalém: um relato sobre a banalidade do mal, de 1963, pretende-se refletir acerca dos mecanismos que produzem o adormecimento da capacidade de pensar frente à necessidade da formação humana. A partir dessa análise, se perceberá que o problema do mal assume um viés radical, uma possibilidade de destruição completa do humano. Na análise do caso Eichmann, Arendt percebeu que o réu agia banalmente, manifestando sua incapacidade de pensar, o que tornou possível a normalização da insensibilidade frente o diferente. Portanto, a banalidade do mal implica na incapacidade de pensar, uma ameaça sempre constante à formação humana

  17. Malária pulmonar: aspectos na tomografia computadorizada de alta resolução - relato de caso

    Directory of Open Access Journals (Sweden)

    Rodrigues Rosana

    2004-01-01

    Full Text Available Neste trabalho é relatado o caso de paciente do sexo masculino, de 38 anos de idade, que desenvolveu quadro de malária com comprometimento pulmonar. A tomografia computadorizada de alta resolução evidenciou espessamento de septos interlobulares e de bainhas peribroncovasculares, com áreas esparsas de atenuação em vidro fosco e de consolidações, além de derrame pleural bilateral, aspectos compatíveis com edema pulmonar. O paciente recebeu tratamento específico, evoluindo bem e tendo alta 11 dias após a internação.

  18. Treatment of the Mal de Debarquement Syndrome: A 1-Year Follow-up

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    Mingjia Dai

    2017-05-01

    Full Text Available The mal de debarquement syndrome (MdDS is a movement disorder, occurring predominantly in women, is most often induced by passive transport on water or in the air (classic MdDS, or can occur spontaneously. MdDS likely originates in the vestibular system and is unfamiliar to many physicians. The first successful treatment was devised by Dai et al. (1, and over 330 MdDS patients have now been treated. Here, we report the outcomes of 141 patients (122 females and 19 males treated 1 year or more ago. We examine the patient’s rocking frequency, body drifting, and nystagmus. The patients are then treated according to these findings for 4–5 days. During treatment, patients’ heads were rolled while watching a rotating full-field visual surround (1. Their symptom severity after the initial treatment and at the follow-up was assessed using a subjective 10-point scale. Objective measures, taken before and at the end of the week of treatment, included static posturography. Significant improvement was a reduction in symptom severity by more than 50%. Objective measures were not possible during the follow-up because of the wide geographic distribution of the patients. The treatment group consisted of 120 classic and 21 spontaneous MdDS patients. The initial rate of significant improvement after a week of treatment was 78% in classic and 48% in spontaneous patients. One year later, significant improvement was maintained in 52% of classic and 48% of spontaneous subjects. There was complete remission of symptoms in 27% (32 of classic and 19% (4 of spontaneous patients. Although about half of them did not achieve a 50% improvement, most reported fewer and milder symptoms than before. The success of the treatment was generally inversely correlated with the duration of the MdDS symptoms and with the patients’ ages. Prolonged travel by air or car on the way home most likely contributed to the symptomatic reversion from the initial successful treatment

  19. Efeitos benéficos e maléficos da malva sylvestris

    Directory of Open Access Journals (Sweden)

    Ana Carolina Locatelli Ecker

    2016-04-01

    Full Text Available Objetivo. Revisar os efeitos benéficos e maléficos da Malva sylvestris para a saúde humana. Materiais e métodos. Foi realizada uma busca na base de dados BIREME, em setembro de 2014, por meio das pala­vras chaves malva AND sylvestris. Foram incluídos os artigos na língua inglesa e portuguesa sem limite de tempo. Foram excluídos os estudos repetidos e aqueles que não abordavam o tema. Resultados. Atra­vés da busca realizada, foram encontrados 56 artigos, destes, foram excluídos dois repetidos, um por encontrar-se no idioma chinês e, 41 por estarem fora do tema (benefícios para animais e solo, proprie­dades químicas da erva, pesquisa em campo de determinadas regiões do mundo abrangendo índices de utilização de muitas espécies de plantas para fins medicinais. Assim, foram, incluídos 12 artigos. Com grande importância terapêutica, a erva tem sido utilizada na área da saúde em geral para inflamações internas e externas, fins quimio-preventivos e antissépticos. Também alivia secreções como catarros, congestionamento das vias respiratórias e age como calmante no sistema neurológico. Segundo pes­quisas, o chá de malva apresenta resultados mais vantajosos do que tratamentos medicamentosos e é uma das mais utilizadas como auto-medicação. Conclusão. A Malva sylvestris é utilizada para muitos fins benéficos para o ser humano desde tempos remotos, mas sua comprovação científica tem ocorrido atualmente, evidenciando a veracidade de suas vantagens na saúde e no tratamento de patologias.

  20. EJERCICIO Y LA DETECCION DEL MAL AGUDO DE MONTAÑA GRAVE

    Science.gov (United States)

    Garófoli, Adrián; Montoya, Paola; Elías, Carlos; Benzo, Roberto

    2012-01-01

    El Mal Agudo de Montaña (MAM) es un conjunto de síntomas inespecíficos padecidos por sujetos que ascienden rápidamente desde baja a alta altura sin adecuada aclimatación. Usualmente es autolimitado, pero las formas graves (edema pulmonar y cerebral) pueden causar la muerte. La hipoxemia exagerada en reposo está relacionada con el desarrollo de MAM pero su valor predictivo es limitado. Dado que el ejercicio en altura se acompaña de mayor hipoxemia y síntomas, postulamos el valor predictivo de un simple test de ejercicio para pronosticar MAM grave. Se estudió el valor predictivo de la saturación de oxígeno en reposo y ejercicio submáximo a 2 700m y 4 300m en 63 sujetos que ascendían al cerro Aconcagua (6 962m). Se consideró desaturación de oxígeno con ejercicio a una disminución >=5% respecto al reposo. Se utilizó la escala de Lake-Louise para establecer la presencia de MAM grave. 6 sujetos presentaron MAM grave (9.5%) y requirieron evacuación. La saturación de oxígeno en reposo a 2 700m no fue significativa para clasificar sujetos que luego desarrollaron MAM grave. Por el contrario, la asociación de desaturación durante el ejercicio a 2 700m más la saturación inapropiada en reposo a 4 300m fue significativa para clasificar a los sujetos que desarrollaron MAM grave con un valor predictivo positivo de 80% y un valor predictivo negativo del 97%. Nuestros resultados son relevantes para el montañismo y sugieren la adición de un simple test de ejercicio en la predicción del MAM grave. PMID:20228017

  1. Securitización en el desierto: Una respuesta al terrorismo en Malí y en Níger, 2009 - 2013.

    OpenAIRE

    Guerrero Escobar, Laura Catalina

    2014-01-01

    Este es un estudio sobre las dinámicas de seguridad en Malí durante el periodo de 2009 a 2013. La investigación busca explicar de qué manera se ha dado un proceso de securitización de los grupos insurgentes frente a la amenaza generada por la proliferación de grupos armados no estatales en el territorio comprendido entre Malí y Níger. Se toma a Níger con el ánimo de ver la existencia de un subcomplejo regional de seguridad entre este país y Malí. De esta manera se afirma que el aumento de las...

  2. Manobras para o tratamento da vertigem posicional paroxística benigna: revisão sistemática da literatura Maneuvers for the treatment of benign positional paroxysmal vertigo: a systematic review

    Directory of Open Access Journals (Sweden)

    Lázaro Juliano Teixeira

    2006-02-01

    Full Text Available A Vertigem Posicional Paroxística Benigna (VPPB é uma das mais freqüentes patologias do sistema vestibular e é caracterizada por episódios de vertigens recorrentes desencadeados por movimentos da cabeça ou mudanças posturais. Há várias opções para o seu tratamento, porém as efetividades terapêuticas das mesmas permanecem controversas. OBJETIVO: Avaliar a efetividade terapêutica das manobras específicas disponíveis para o tratamento da VPPB. METODOLOGIA: Realizou-se uma busca eletrônica nas principais bases de dados, selecionando-se estudos clínicos randomizados envolvendo adultos com diagnóstico de VPPB confirmado com o teste de Dix-Hallpike e tratamento com manobras específicas (Epley ou Semont, por exemplo. Considerou-se como desfecho clínico a negativação do teste de Dix-Hallpike e a melhora das queixas subjetivas. Agruparam-se em metanálise os estudos com Escala de Jadad igual ou superior a três. RESULTADOS: Cinco estudos clínicos preencheram os critérios de inclusão, ou seja, ensaios randomizados de fase I comparando a manobra de Epley com placebos e controles. A metanálise mostra evidência dos efeitos benéficos da manobra de Epley para o tratamento do canal semicircular posterior (magnitude do efeito de 0,11 [IC 95% 0.05, 0.26] de melhora objetiva (Dix-Halpike após uma semana, 0.24 [IC 95% 0.13, 0.45] após um mês e 0.16 [IC 95% 0.08, 0.33] de melhora referida pelos pacientes após a primeira semana. CONCLUSÃO: Evidencia-se boa eficácia clínica da manobra de Epley para o tratamento da VPPB do canal semicircular posterior. Contrariamente, trabalhos com a manobra de Semont e as propostas de manejo dos demais canais semicirculares não obtiveram qualidade metodológica satisfatória, não sendo possível demonstrar a efetividade dos mesmos.Benign Paroxysmal Positional Vertigo (BPPV is one of the most frequent diseases of the vestibular system and it is characterized by episodes of recurrent vertigo

  3. malERA: An updated research agenda for basic science and enabling technologies in malaria elimination and eradication

    Science.gov (United States)

    2017-01-01

    Basic science holds enormous power for revealing the biological mechanisms of disease and, in turn, paving the way toward new, effective interventions. Recognizing this power, the 2011 Research Agenda for Malaria Eradication included key priorities in fundamental research that, if attained, could help accelerate progress toward disease elimination and eradication. The Malaria Eradication Research Agenda (malERA) Consultative Panel on Basic Science and Enabling Technologies reviewed the progress, continuing challenges, and major opportunities for future research. The recommendations come from a literature of published and unpublished materials and the deliberations of the malERA Refresh Consultative Panel. These areas span multiple aspects of the Plasmodium life cycle in both the human host and the Anopheles vector and include critical, unanswered questions about parasite transmission, human infection in the liver, asexual-stage biology, and malaria persistence. We believe an integrated approach encompassing human immunology, parasitology, and entomology, and harnessing new and emerging biomedical technologies offers the best path toward addressing these questions and, ultimately, lowering the worldwide burden of malaria. PMID:29190277

  4. Fingerpainting am Touchscreen. Fünf Mal- und Zeichen-Apps für Android-Tablets

    Directory of Open Access Journals (Sweden)

    Christoph Kaindel

    2015-06-01

    Full Text Available Malen auf dem Touchscreen eines Smartphones oder Tablets ist eine natürliche und intuitive Tätigkeit; anders als bei der Nutzung eines Grafiktabletts am PC gibt es so gut wie keine Umstellungsphase. Christoph Kaindel hat für uns fünf Mal- und Zeichen-Apps unter die Lupe genommen. Bereits für Kinder ist in den diversen Appstores eine große Zahl an einfachen Mal-Apps zu finden, mit meist nur wenigen Einstellungsmöglichkeiten und oft fragwürdiger Qualität. Am anderen Ende des Spektrums liegt der professionelle Einsatz von Tablets im Grafikbereich, für den spezialisierte und entsprechend teure Geräte notwendig sind. Ich werde einige Apps aus dem Mittelfeld vorstellen, die sich für einfache wie anspruchsvolle Vorhaben und Projekte eignen, auch auf schwächeren Tablets laufen und preisgünstig oder gratis sind. Alle Apps bieten die Möglichkeit, unterwegs zu malen, zu skizzieren, Fotos zu verfremden und die entstandenen Bilder am PC weiter bearbeiten zu können. Für PCs gibt es einige empfehlenswerte kostenlose Malprogramme, die ich bereits in einem anderen Artikel (http://medienimpulse.at/articles/view/616 vorgestellt habe.

  5. Presencia de Anopheles (Nyssorhynchus benarrochi en áreas de selva con transmisión malárica

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    Roberto Fernández L

    2004-10-01

    Full Text Available Objetivos: Demostrar la presencia de An. (Nys. benarrochi en áreas de transmisión malárica, donde es frecuentemente identificado como An. evansae. Materiales y métodos: Se colectaron mosquitos en San José (Pucallpa, Muniches y Andoas (Alto Amazonas, localidades con transmisión de malaria. Con estos mosquitos se efectuaron crías biológicas en laboratorio con la finalidad de obtener material de estudio como son exuvias de larvas, pupas, adultos hembras y machos. Se efectuaron montajes de exuvias de larvas y pupas asociados con sus respectivos adultos, disecciones de las genitalias de machos y biometría de los adultos machos y hembras. Resultados: Además de las verificaciones efectuadas en el campo, basadas en el estudio de inmaduros y adultos, las crías biológicas efectuadas confirmaron la presencia de An. benarrochi en las localidades mencionadas. Asimismo, confirmaron también la existencia de gran variabilidad de los caracteres morfológicos externos, que pueden inducir al error en las identificaciones. Conclusiones: En las áreas maláricas estudiadas, la especie identificada como An. (Nys. evansae corresponde a An. (Nys. benarrochi, demostrado con nuestros estudios. Dada la variabilidad de caracteres que dificultan la identificación de las especies afines, es necesario realizar estudios completos con la finalidad de conocer la fauna local de anofelinos.

  6. A banalidade do mal e as possibilidades da educação moral: contribuições arendtianas

    Directory of Open Access Journals (Sweden)

    Marcelo Andrade

    2010-01-01

    Full Text Available Más que una época de crisis, enfrentamos hoy una crisis de época en la cual la educación desempeña un papel fundamental. En este sentido, el presente trabajo es una relectura de la obra de Hannah Arendt, filósofa que pensó y vivió en tiempos sombríos, con el fin de aclarar algunos conceptos que son fundamentales para que hoy pueda repensarse la educación moral o la educación en valores. A través de un estudio centrado en las obras Eichmann en Jerusalén: un estudio sobre la banalidad del mal y La vida del espíritu, este trabajo busca comprender cómo y por qué Hannah Arendt acuñó el concepto banalidad del mal y en qué sentido este se relaciona con el vacío del pensamiento y con una propuesta de educación en valores.

  7. Abuso de drogas e transtornos alimentares entre mulheres: sintomas de um mal-estar de gênero?

    Directory of Open Access Journals (Sweden)

    Regina Helena Simões-Barbosa

    Full Text Available Resumo: O artigo discute o abuso de drogas e os transtornos alimentares sob as perspectivas críticas de gênero e do cuidado em saúde. Postula-se que o sofrimento subjetivo pode se expressar no corpo por meio das doenças psicossomáticas. Nessa perspectiva, a insaciável fome consumista das drogas ou de bens supérfluos, bem como o adoecimento pela fome voluntária em busca de um ideal de esbeltez, como na anorexia e bulimia, podem ser sintomas que denunciam o sofrimento feminino. Uma revisão nos campos da saúde coletiva e das teorias feministas destaca a magnitude dos fenômenos da medicalização e mercantilização da saúde presentes na psiquiatrização do mal-estar feminino. Na transição de gênero das sociedades capitalistas, as cobranças sociais pelo desempenho dos velhos e novos papéis femininos acentuam sentimentos de inadequação, traduzidos no mal-estar de gênero que circunda o abuso de drogas e os transtornos alimentares, analisados como patologias de protesto. Propõe-se o resgate do ideário do Programa de Assistência Integral à Saúde da Mulher, orientado pela integralidade, para enfrentar tais desafios.

  8. First successful reduction of clinical allergenicity of food by genetic modification: Mal d 1-silenced apples cause fewer allergy symptoms than the wild-type cultivar

    DEFF Research Database (Denmark)

    Dubois, A. E. J.; Pagliarani, G.; Brouwer, R. M.

    2015-01-01

    BACKGROUND: Genetic modification of allergenic foods such as apple has the potential to reduce their clinical allergenicity, but this has never been studied by oral challenges in allergic individuals. METHODS: We performed oral food challenges in 21 apple-allergic individuals with Elstar apples...... which had undergone gene silencing of the major allergen of apple, Mal d 1, by RNA interference. Downregulation of Mal d 1 gene expression in the apples was verified by qRT-PCR. Clinical responses to the genetically modified apples were compared to those seen with the wild-type Elstar using a visual...

  9. Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88.

    Science.gov (United States)

    Dunne, Aisling; Ejdeback, Mikael; Ludidi, Phumzile L; O'Neill, Luke A J; Gay, Nicholas J

    2003-10-17

    The Toll/interleukin 1 receptor (TIR) domain is a region found in the cytoplasmic tails of members of the Toll-like receptor/interleukin-1 receptor superfamily. The domain is essential for signaling and is also found in the adaptor proteins Mal (MyD88 adaptor-like) and MyD88, which function to couple activation of the receptor to downstream signaling components. Experimental structures of two Toll/interleukin 1 receptor domains reveal a alpha-beta-fold similar to that of the bacterial chemotaxis protein CheY, and other evidence suggests that the adaptors can make heterotypic interactions with both the receptors and themselves. Here we show that the purified TIR domains of Mal and MyD88 can form stable heterodimers and also that Mal homodimers and oligomers are dissociated in the presence of ATP. To identify structural features that may contribute to the formation of signaling complexes, we produced models of the TIR domains from human Toll-like receptor 4 (TLR4), Mal, and MyD88. We found that although the overall fold is conserved the electrostatic surface potentials are quite distinct. Docking studies of the models suggest that Mal and MyD88 bind to different regions in TLRs 2 and 4, a finding consistent with a cooperative role of the two adaptors in signaling. Mal and MyD88 are predicted to interact at a third non-overlapping site, suggesting that the receptor and adaptors may form heterotetrameric complexes. The theoretical model of the interactions is supported by experimental data from glutathione S-transferase pull-downs and co-immunoprecipitations. Neither theoretical nor experimental data suggest a direct role for the conserved proline in the BB-loop in the association of TLR4, Mal, and MyD88. Finally we show a sequence relationship between the Drosophila protein Tube and Mal that may indicate a functional equivalence of these two adaptors in the Drosophila and vertebrate Toll pathways.

  10. Alterações do desenvolvimento de crianças prematuras nascidas de mães com malária no periodo gestacional

    OpenAIRE

    Simões, Maria da Conceição Ribeiro

    2012-01-01

    Objetivo : O estudo buscou avaliar as alterações no desenvolvimento de crianças prematuras nascidas de mães com malária no periodo gestacional, em Porto Velho, Rondônia. O objetivo principal é descrever as alterações encontradas nessas crianças aplicando um teste preditivo para alterações no desenvolvimento e compará-las à um grupo controle de crianças prematuras nascidas de mães que não apresentaram malária no periodo gestacional. Métodos : Por ser um estudo do tipo transvers...

  11. Mal tiempo, tiempo maligno, tiempo de subversión ritual. La temposensitividad agrofestiva invernal

    Directory of Open Access Journals (Sweden)

    Del Campo Tejedor, Alberto

    2006-06-01

    ícolas y expresivo (rituales y fiestas; y, finalmente, un tiempo bipolar, que se experimenta desde antiguo en dos estaciones —invierno y verano—, base de una temposensitividad agrofestiva igualmente dicotómica, que es analizada a raíz de la siguiente hipótesis: durante los meses de buen tiempo, especialmente mayo y junio, los rituales de nuestro entorno funcionan con un sentido propiciatorio y de exaltación positiva, escenificando miméticamente la unión entre tierra, vegetación, animal y hombre a través de prototipos o arquetipos que recrean simbólicamente el orden natural de las cosas. Por el contrario, las fiestas y rituales invernales —desde Todos los Santos hasta el Carnaval, y muy especialmente los días en torno a la Navidad— tienen en común su carácter grotesco y de inversión del orden, que expresa en clave simbólica, con una lógica jocoseria y ambigua, el lado oscuro de la existencia, conjurando ritualmente los miedos al mal tiempo, al tiempo aciago y nefasto, al tiempo del frío, la noche, el hambre y la muerte.

  12. Mal de Asclepio o Síndrome Judicial Médico

    Directory of Open Access Journals (Sweden)

    Hernán Urbina Joiro

    2015-12-01

    Full Text Available

    Se asocian crecientemente, de manera criminal, abogados, pacientes y médicos perversos contra médicos honestos, alineando el factor que peor puede degradar la medicina de hoy y potenciar sus otros males. Siendo dios de la medicina, el nacimiento y la muerte de Asclepio estuvieron marcados por la vileza, la que hoy amenaza de muerte a la profesión médica. Pero no hay que olvidar que finalmente Asclepio pudo ser resguardado de la perversidad.

    No se trata de la situación de quien denuncia legítimamente una transgresión cometida por un médico. El Mal de Asclepio o Síndrome Judicial Médico describe la actuación calculada por auténticos «enfermos» —en el sentido sociopático—, con manifiesta intención de ocasionar daño a médicos inocentes, comúnmente a través de prácticas delictivas, ocasionando además males permanentes en la salud física y mental de quienes se habían esforzado, irónicamente, para sanar a los demás, en esta era de degradación de la profesión médica, en este momento extraño donde el bastón de Asclepio, dios de la medicina, fue cambiado por el caduceo de Mercurio, dios del comercio y también de los ladrones (1.

    Asclepio fue un hijo no nacido, rescatado por un prodigio desde el vientre de su madre muerta y a punto de ser consumida por la pira funeraria. Coronis —o Corónide—, la madre, lo concibió tras un asalto del dios Apolo en la rivera de un río y, sin saber de su estado, cumplió con un pacto matrimonial arreglado por su padre, lo que incitó a Apolo a dar muerte a su joven esposo e impulsó a Artemisa, hermana de Apolo, a asesinar a flechazos a la propia Coronis. Fue el mismo Apolo quien, en el último momento, resolvió extraer del cadáver de Coronis al niño que puso por nombre Asclepio y que en adelante lucharía contra la muerte, incluso resucitando difuntos, hasta que la propia muerte —Hades— convenció de mala fe a Zeus, lo indujo al error —que más tarde

  13. O problema do mal: a interpretação de São Boaventura = The problem of evil: the interpretation of Saint Bonaventure

    Directory of Open Access Journals (Sweden)

    Vasconcellos, Manoel

    2012-01-01

    Full Text Available Tomando, especialmente, o Breviloquium como guia, podemos entender o modo como São Boaventura analisa o problema do mal e sua relação com o pecado. O homem foi criado bom, para viver num mundo bom. Com o pecado, rompeu com o projeto divino, instaurando o mal no mundo. Deus, o princípio primeiro e perfeitíssimo, contudo, não deixa de levar à perfeição sua obra, razão pela qual vem ao encontro do homem para vencer o pecado e o mal. Numa reflexão em que Filosofia e Teologia se entrecruzam, Boaventura, ao discorrer sobre a origem, transmissão e superação do mal, deixa transparecer o papel singular e afirmativo do homem, pois, apesar do pecado, não perdeu sua atração natural às virtudes, sendo capaz de agir bem

  14. Development of hypo-allergenic apples: silencing of the major allergen Mal d 1 gene in "Elstar" apple and the effect of grafting

    DEFF Research Database (Denmark)

    Krath, Britta; Eriksen, Folmer Damsted; Pedersen, Bjarne H.

    2009-01-01

    Many people who are allergic to birch pollen are also allergic to apple fruit, due to cross-allergenicity. Since apples are the most extensively consumed fruit in Europe, it is highly relevant to develop a hypo-allergenic apple. Apples with significantly reduced levels of the allergen, Mal d 1, may...

  15. CADM1, MAL and miR124-2 methylation analysis in cervical scrapes to detect cervical and endometrial cancer

    NARCIS (Netherlands)

    De Strooper, Lise M. A.; van Zummeren, Marjolein; Steenbergen, Renske D. M.; Bleeker, Maaike C. G.; Hesselink, Albertus T.; Schuurs-Wisman, G. Bea A.; Snijders, Peter J. F.; Heideman, Danielle A. M.; Meijer, Chris J. L. M.

    2014-01-01

    Aims Gene promoter hypermethylation is recognised as an essential early step in carcinogenesis, indicating important application areas for DNA methylation analysis in early cancer detection. The current study was set out to assess the performance of CADM1, MAL and miR124-2 methylation analysis in

  16. Molecular characterization of multivalent bioconjugates by size-exclusion chromatography (SEC) with multi-angle laser light scattering (MALS)

    Science.gov (United States)

    Pollock, Jacob F.; Ashton, Randolph S.; Rode, Nikhil A.; Schaffer, David V.; Healy, Kevin E.

    2013-01-01

    The degree of substitution and valency of bioconjugate reaction products are often poorly judged or require multiple time- and product- consuming chemical characterization methods. These aspects become critical when analyzing and optimizing the potency of costly polyvalent bioactive conjugates. In this study, size-exclusion chromatography with multi-angle laser light scattering was paired with refractive index detection and ultraviolet spectroscopy (SEC-MALS-RI-UV) to characterize the reaction efficiency, degree of substitution, and valency of the products of conjugation of either peptides or proteins to a biopolymer scaffold, i.e., hyaluronic acid (HyA). Molecular characterization was more complete compared to estimates from a protein quantification assay, and exploitation of this method led to more accurate deduction of the molecular structures of polymer bioconjugates. Information obtained using this technique can improve macromolecular engineering design principles and better understand multivalent macromolecular interactions in biological systems. PMID:22794081

  17. La seducción del mal: crimen, arte, dictadura y poesía en "Estrella distante"

    OpenAIRE

    Díaz de la Cruz, Elena

    2017-01-01

    Trabajo de fin de Grado. Grado en Filología Hispánica. Curso académico 2016-2017 [ES]En la presente investigación se trabajará en torno al mal y su seducción a través del arte contemporáneo, la dictadura, el crimen, y todo ello envuelto en la poesía como forma de llevar a cabo la finalidad más antipoética que nos pudiéramos imaginar. El espacio “entre”, lo indefinido y el abismo va a ser el terreno donde la poesía cobra vida pero, además, crea un aura de diferentes posibilidades en torno a...

  18. Intrinsic magnetic properties of Sm2Fe17-xMxNy/Cy (M=Al, Ga or Si)

    International Nuclear Information System (INIS)

    Kubis, M.; Eckert, D.; Gebel, B.; Mueller, K.-H.; Schultz, L.

    2000-01-01

    Curie temperature T c , saturation polarization J s and anisotropy field H a of Sm 2 Fe 17-x M x N y /C y with M=Al, Ga or Si (x≤3, y∼3) were determined by thermomagnetic measurements and a numerical fitting procedure of demagnetization curves. An increasing amount of the substitutional element M leads to an increase of T c of the Sm 2 Fe 17-x M x parent compounds and generally to a decrease of T c , J s and H a for the interstitial nitrides and carbides. However, for small M contents, x≤1, an increased H a was observed compared to the substitution-free interstitial compounds. Gas-carburized and melt-carburized Sm 2 Fe 15 Ga 2 C y samples showed large differences in J s and H a but identical T c values

  19. Regresso às origens: pistas para a construção do bem e do mal

    Directory of Open Access Journals (Sweden)

    Miguel Ângelo Rodrigues Fernandes

    2011-01-01

    Full Text Available Nowadays, divisions still impose themselves. One of those divisions has become particularly relevant in contemporary culture. On one side, the Axis of Good. On the other, the Axis of Evil. In between both ends, conflicts for power. That dualism and those conflicts, building blocks of the process of constructing cultural identities, being contemporary, find part of their history in discourses of old, of which Christianity is a part. / Atualmente, as divisões continuam a impor-se. Uma dessas divisões tornou-se particularmente pregnante na cultura contemporânea. De um lado, o Eixo do Bem. Do outro, o Eixo do Mal. Mediando os dois polos, conflitos de poder. Esse dualismo e esses conflitos, constituintes do processo de construção de identidades culturais, ainda que contemporâneos, encontram parte da sua história em discursos antigos, que o Cristianismo integra.

  20. Viveret Patrick, 2005, Pourquoi ça ne va pas plus mal?, Fayard, 264 p.

    Directory of Open Access Journals (Sweden)

    Fabien Thurette

    2008-05-01

    Full Text Available Patrick Viveret est philosophe de formation et Conseiller-maître à la Cour des comptes. Il a, en outre, été chargé d’une mission, confiée par l'éphémère Secrétaire d'État à l'économie solidaire Guy Hascoët, puis prolongée par le Président Chirac sur une « autre approche de la richesse », dont le rapport final a été publié sous le titre Reconsidérer la richesse (2004.Dans son essai Pourquoi ça ne va pas plus mal ? publié en 2005, Patrick Viveret nous livre une analyse philosophique sur le « m...

  1. Critérios histopatológicos para diagnóstico de melanoma maligno cutâneo: análise comparativa de sua freqüência em lesões benignas e melanomas de pequena espessura (< 2 mm Histopathological criteria for cutaneous malignant melanoma: comparative analysis between benign and thin malignant lesions (< 2 mm

    Directory of Open Access Journals (Sweden)

    Luiz Alberto Veronese

    2007-10-01

    Full Text Available INTRODUÇÃO: A histopatologia convencional continua sendo o padrão-ouro no diagnóstico dos melanomas cutâneos, apesar do progresso da imuno-histoquímica e da biologia molecular. Os critérios microscópicos existentes para esse diagnóstico são numerosos, porém nenhum deles é específico para se afirmar que uma determinada lesão é maligna quando ele está presente, ou é benigna na sua ausência. Alguns critérios têm uma relevância maior para o diagnóstico em relação a outros. OBJETIVO: Este estudo propõe uma análise daqueles critérios considerados mais importantes, comparando sua presença em lesões melanocíticas benignas e melanomas. MATERIAL E MÉTODOS: Foram estudadas 33 lesões melanocíticas benignas (nevo de Spitz: 13; nevo de Reed: 6; nevo displásico: 6; nevo congênito: 3; nevo adquirido: 3; nevo combinado: 1; nevo recorrente: 1, bem como 101 casos de melanomas extensivo/superficiais: 25 intra-epidérmicos e 76 invasivos de pequena espessura (INTRODUCTION: Conventional histopathology has been considered as the gold standard in the diagnosis of cutaneous malignant melanoma, despite the progress of molecular biology and immunohistochemistry. There are many microscopic criteria for diagnosis of melanoma, however there is not a single one that can be useful to define malignancy. AIM: Our purpose is to analyse the criteria considered more important to the diagnosis of melanoma, comparing their presence in benign melanocytic lesions and melanomas. MATERIAL AND METHODS: We studied 33 benign melanocytic lesions (Spitz nevi, 13; Reed nevi, 6; dysplastic nevi, 6; congenital nevi, 3; acquired nevi, 3; combined nevus, 1; recurrent nevus, 1 and 101 extensive/superficial melanomas (25 in situ and 76 invasive up to 2 mm thickness. RESULTS: Some criteria showed high frequency in benign lesions, showing low-specificity, while others had low-positivity in the benign and high-frequency in malignant lesions, consequently high

  2. The method of producing climate change datasets impacts the resulting policy guidance and chance of mal-adaptation

    Directory of Open Access Journals (Sweden)

    Marie Ekström

    2016-12-01

    Full Text Available Impact, adaptation and vulnerability (IAV research underpin strategies for adaptation to climate change and help to conceptualise what life may look like in decades to come. Research draws on information from global climate models (GCMs though typically post-processed into a secondary product with finer resolution through methods of downscaling. Through worked examples set in an Australian context we assess the influence of GCM sub-setting, geographic area sub-setting and downscaling method on the regional change signal. Examples demonstrate that choices impact on the final results differently depending on factors such as application needs, range of uncertainty of the projected variable, amplitude of natural variability, and size of study region. For heat extremes, the choice of emissions scenario is of prime importance, but for a given scenario the method of preparing data can affect the magnitude of the projection by a factor of two or more, strongly affecting the indicated adaptation decision. For catchment level runoff projections, the choice of emission scenario is less dominant. Rather the method of selecting and producing application-ready datasets is crucial as demonstrated by results with opposing sign of change, raising the real possibility of mal-adaptive decisions. This work illustrates the potential pitfalls of GCM sub-sampling or the use of a single downscaled product when conducting IAV research. Using the broad range of change from all available model sources, whilst making the application more complex, avoids the larger problem of over-confidence in climate projections and lessens the chance of mal-adaptation.

  3. Light fractionation increases the efficacy of ALA-PDT but not of MAL-PDT: What is the role of (vascular) endothelial cells?

    Science.gov (United States)

    de Bruijn, H. S.; de Vijlder, H. C.; de Haas, E. R. M.; van der Ploeg-van den Heuvel, A.; Kruijt, B.; Poel-Dirks, D.; Sterenborg, H. J. C. M.; ten Hagen, T. L. M.; Robinson, D. J.

    2009-06-01

    Photodynamic therapy (PDT) using protoporpyrin IX (PpIX) precursors like 5-aminolevulinic acid (ALA) or methyl-aminolevulinate (MAL) has shown to be effective in the treatment of various skin diseases. Using ALA we have shown in numerous studies a significantly improved efficacy by applying light fractionation with a long dark interval. In contrast, in the hairless mouse model, the PDT efficacy using MAL is unaffected by adopting this approach. More acute edema is found after ALA-PDT suggesting a difference in response of endothelial cells to PDT. To investigate the role of endothelial cells, cryo-sections of hairless mouse skin after 4 hours of topical MAL or ALA application were stained with a fluorescent endothelial cell marker (CD31). Co-localization of this marker with the PpIX fluorescence was performed using the spectral imaging function of the confocal microscope. We have also used intra-vital confocal microscopy to image the PpIX fluorescence distribution in correlation with the vasculature of live mouse skin. Our results show PpIX fluorescence at depth in cryo-sections of mouse skin after 4 hours of topical application. Co-localization has shown to be difficult due to the changes in tissue organization caused by the staining procedure. As expected we found high PpIX fluorescence levels in the epidermis after both MAL and ALA application using intra-vital microscopy. After ALA application more PpIX fluorescence was found deep in the dermal layer of the skin than after MAL. Furthermore we detected localized fluorescence in unidentified structures that could not be correlated to blood vessels or nerves.

  4. First successful reduction of clinical allergenicity of food by genetic modification: Mal d 1-silenced apples cause fewer allergy symptoms than the wild-type cultivar.

    Science.gov (United States)

    Dubois, A E J; Pagliarani, G; Brouwer, R M; Kollen, B J; Dragsted, L O; Eriksen, F D; Callesen, O; Gilissen, L J W J; Krens, F A; Visser, R G F; Smulders, M J M; Vlieg-Boerstra, B J; Flokstra-de Blok, B J; van de Weg, W E

    2015-11-01

    Genetic modification of allergenic foods such as apple has the potential to reduce their clinical allergenicity, but this has never been studied by oral challenges in allergic individuals. We performed oral food challenges in 21 apple-allergic individuals with Elstar apples which had undergone gene silencing of the major allergen of apple, Mal d 1, by RNA interference. Downregulation of Mal d 1 gene expression in the apples was verified by qRT-PCR. Clinical responses to the genetically modified apples were compared to those seen with the wild-type Elstar using a visual analogue scale (VAS). Gene silencing produced two genetically modified apple lines expressing Mal d 1.02 and other Mal d 1 gene mRNA levels which were extensively downregulated, that is only 0.1-16.4% (e-DR1) and 0.2-9.9% (e-DR2) of those of the wild-type Elstar, respectively. Challenges with these downregulated apple lines produced significantly less intense maximal symptoms to the first dose (Vmax1) than with Elstar (Vmax1 Elstar 3.0 mm vs 0.0 mm for e-DR1, P = 0.017 and 0.0 mm for e-DR2, P = 0.043), as well as significantly less intense mean symptoms per dose (meanV/d) than with Elstar (meanV/d Elstar 2.2 mm vs 0.2 mm for e-DR1, P = 0.017 and 0.0 mm for e-DR2, P = 0.043). Only one subject (5%) remained symptom-free when challenged with the Elstar apple, whereas 43% did so with e-DR1 and 63% with e-DR2. These data show that mRNA silencing of Mal d 1 results in a marked reduction of Mal d 1 gene expression in the fruit and reduction of symptoms when these apples are ingested by allergic subjects. Approximately half of the subjects developed no symptoms whatsoever, and virtually all subjects wished to consume the apple again in the future. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  5. O puru-puru da Amazônia (Pinta, Carate, Mal del Pinto etc

    Directory of Open Access Journals (Sweden)

    F. Nery Guimarães

    1948-03-01

    Full Text Available 1 "Purú-purú" é uma palavra indígena que quer dizer "pintado" ou "manchado", peculiar à Amazonia Brasileira. Com êsse nome é designada uma dermatose referida entre os selvicolas desde 1774, por Ribeiro Sampaio. Certas tribus, com alta incidência da moléstia passaram a ser cahamadas também "Purú-purús", o mesmo acontecendo com o rio onde habitavam - Rio Purús. 2 A doença existe na bacia do Rio Solimões e seus principais afluentes: Javari, Juruá, Purús, Içá, Japurá, e Negro. Por esses rios, o fóco da dermatose se continua nos países limitrofes com o Brasil: Guianas, Venezuela, Colombia, Perú (Equador e Bolivia. 3 Desde 1890 essa dermatose foi relacionada à pinta (carate ou mal del pinto por P. S. de Magalhães, idéa essa depois defendida por Juliano Moreira, Carlos Chagas, Roquete Pinto, Wappeus, O. da Fonseca Filho, Da Matta, Brumpt e outros, baseados na semelhança clínica e na terapêutica. Recentemente (1945, essa provavel identidade das duas dermatoses, recebeu fundamento sorológico de Biocca (que verificou a positividade das reações de Kline e Kahn em doentes de purú-purú, e, pelo presente trabalho, recebe base clínico-epidemio-anatomo-patológica. 4 Sob o ponto de vista clínico, as lesões cutaneas discromicas da moléstia, são de 3 órdens: a lesões papulo-eritemato-escamosas, isoladas ou não, arredondadas, pruriginosas e de bordos nitidos; b lesões maculo-escamosas, maiores mais pálidas, ás vezes já mostrando alterações pigmentares na parte central; c máculas discromod´rmicas, lisas ou ligeiramente escamosas, com maior ou menor alteração pigmentar, as quais assumem diferentes aspéctos, consequentes à hipo - ou hiperpigmentação, variaveis também com a côr do paciente. As colorações predominantes nas manchas, são o branco, o preto e o vermelho, com tonalidades eminentemente variaveis. Embora raramente, nessas extensas dermodiscromias, observa-se superposição de lesões papulo

  6. Buddha and tiger; Mal Buddha, mal Tiger

    Energy Technology Data Exchange (ETDEWEB)

    Schott, Christina

    2010-02-15

    Thailand is foremost in renewable energy in South East Asia, and the country is planning to extend its capacities in this field. At the same time, the country dreams of atomic energy and also pushes doubtful megascale projects in its neighbouring countries. (orig.)

  7. Contribuição ao estudo do mal de cadeiras na Ilha de Marajó

    Directory of Open Access Journals (Sweden)

    Geth Jansen

    1941-01-01

    Full Text Available Como resultado de inspeções feitas à ilha de Marajó o autor assinala: 1º O mal de cadeiras continua existindo na ilha de Marajó sob a forma enzoótica, ao contrário do que pensavam os criadores, julgando-o extinto. As doenças designadas por estes como "barriga inchada" e "mormo seco", responsaveis pela grande mortalidade dos equinos, foram identificadas pelo autor como tal de cadeiras. 2º O autor considera indispensável para a pesquisa do trypanosoma o processo de inoculação em animais de laboratório, tendo utilizado para esse fim camondongos e ratos brancos. 3º Os surtos epizoóticos anuais coincidem com a época das chuvas, ocasião em que surgem os insetos hematófagos, o que faz pensar no papel desses últimos como transmissores. 4º Os cavalos podem atravessar o ano com trypanosomas no sangue e em estado de saude aparente, constituindo assim depositários do mal de cadeiras. 5º O extermínio da capivara, em consequência do seu aproveitamento econômico não modificou o carater endêmico da doença na ilha de Marajó. 6º O autor observou que os trypanosomas no tubo digestivo de Stomoxys e Tabanideos, ao cabo de 8 horas, apresentavam com movimentos diminuidos e em formas arrendondadas, não conseguindo inoculações positivas com esse material. 7º A saliva de um morcego do gênero Desmodus, que se infectou no laboratório, alimentando-se em animal doente, colhida de modo a evitar lesões da mucosa e consequente contaminação pelos trypanosomas do sangue circulante, mostrou-se incapaz de infectar, por inoculação, animais sensiveis. Este mesmo morcego não transmitiu a doença a um cão, o qual sugou durante 80 dias. Recentemente (1941 empregando um exemplar do gênero Desmodus, também infectado experimentalmente por alimentação em animal de laboratório, conseguimos transmitir o Trypanosoma equinum a uma cobaia normal. Este assunto será ventilado posteriormente.

  8. SUPERVISION IMPLEMENTATION IN MANAGEMENT QUALITY: AN ATTEMPT TO IMPROVE THE QUALITY OF LEARNING AT MADRASAH ALIYAH DARUL A’MAL METRO

    Directory of Open Access Journals (Sweden)

    Subandi Subandi

    2016-03-01

    Full Text Available The primary purpose of this qualitative study is to identify and analyze supervision by implementing management quality to improve the quality of learning at Madrasah Aliyah Darul A’mal Metro, Lampung. The quality of management implementation is elaborated in the steps of assurance of learning quality. Two instruments, which consist of observation and questionnaire, were used in this study of which each instrument was analyzed based the deductive framework. The results of this study from each instrument revealed four steps of assurance of learning quality, among others (1 by socializing academic supervision program and its advantages to all stake holders, and (2 by implementing stages of assurance through academic supervision by the principals of Madrasah Aliyah Darul A’mal and supervisor, (3 performing supervision that is equipped with valid instrument to measure learning success, (4 performing the follow-up program by clinical and group discussion to provide appropriate model of performance.

  9. Crystallization, data collection and data processing of maltose-binding protein (MalE) from the phytopathogen Xanthomonas axonopodis pv. citri

    International Nuclear Information System (INIS)

    Souza, C. S.; Ferreira, L. C. S.; Thomas, L.; Barbosa, J. A. R. G.; Balan, A.

    2009-01-01

    The Xanthomonas axonopodis pv. citri maltose-binding protein MalE has been crystallized at 293 K using the hanging-drop vapour-diffusion method. Maltose-binding protein is the periplasmic component of the ABC transporter responsible for the uptake of maltose/maltodextrins. The Xanthomonas axonopodis pv. citri maltose-binding protein MalE has been crystallized at 293 K using the hanging-drop vapour-diffusion method. The crystal belonged to the primitive hexagonal space group P6 1 22, with unit-cell parameters a = 123.59, b = 123.59, c = 304.20 Å, and contained two molecules in the asymetric unit. It diffracted to 2.24 Å resolution

  10. Avaliação de genótipos tetraploides de bananeira cultivados em área infestada pelo agente causal do mal-do-Panamá

    Directory of Open Access Journals (Sweden)

    Sebastião de Oliveira e Silva

    2011-03-01

    Full Text Available O mal-do-Panamá é uma doença que causa grandes prejuízos à bananicultura no Brasil, uma vez que as principais cultivares em uso são suscetíveis ao Fusarium. Este trabalho teve como objetivos avaliar características agronômicas e resistência ao mal-do-Panamá de híbridos tetraploides de bananeira. O experimento foi conduzido no campo experimental da Embrapa Mandioca e Fruticultura Tropical, em delineamento casualizado, com 14 tratamentos e 10 repetições, nos anos de 2000 e 2001. Foram avaliados 14 tetraploides (FHIA-03, PV03-44, PC42-01, PV42-53, PV42-68, PV42-81, PV42-85, PV42-129, PV42-142, PV42-143, SH3640, ST12-31, ST42-08 e YB42-21 e a cultivar Maçã, usada como testemunha. Avaliaram-se as características altura da planta (m e diâmetro do pseudocaule (cm a 30 cm do solo, peso da massa do cacho (kg, penca (kg e fruto (g, número de pencas por cacho, de frutos por penca e de dias do florescimento à colheita, e a incidência do mal-do-Panamá. As médias dos genótipos foram agrupadas pelo teste de Scott e Knott, a 5% de probabilidade. Observa-se uma ampla variação genética nos caracteres avaliados. Os genótipos FHIA 03, ST12-31, SH3640, PV42-142, PV42-53 e PV42-68apresentam boas características agronômicas e resistência ao mal-do-Panamá.

  11. Lower expression of CADM1 and higher expression of MAL in Merkel cell carcinomas are associated with Merkel cell polyomavirus infection and better prognosis.

    Science.gov (United States)

    Iwasaki, Takeshi; Matsushita, Michiko; Nonaka, Daisuke; Nagata, Keiko; Kato, Masako; Kuwamoto, Satoshi; Murakami, Ichiro; Hayashi, Kazuhiko

    2016-02-01

    Merkel cell carcinoma (MCC) is a clinically aggressive neuroendocrine skin cancer; 80% of the cases are associated with the Merkel cell polyomavirus (MCPyV). We previously reported that MCPyV-negative MCCs have more irregular nuclei with abundant cytoplasm and significantly unfavorable outcomes than do MCPyV-positive MCCs. These results suggest that some cell adhesion or structural stabilization molecules are differently expressed depending on MCPyV infection status. Thus, we investigated the association of prognosis or MCPyV infection status in MCCs with cell adhesion molecule 1 (CADM1)/differentially expressed in adenocarcinoma of the lung protein 1 (DAL-1)/membrane protein, palmitoylated 3 (MPP3) tripartite complex and mal T-cell differentiation protein (MAL) expression, which play important roles in cell adhesion and oncogenesis and are related to cancer outcomes in various malignancies, to elucidate the role of these molecules. We analyzed the pathological and molecular characteristics of 26 MCPyV-positive and 15 MCPyV-negative MCCs. Univariate Cox regression analysis showed that advanced age (hazard ratio [HR], 8.249; P = .007) and high CADM1 expression (HR, 5.214; P = .012) were significantly unfavorable overall survival parameters, whereas MCPyV infection (HR, 0.043, P Merkel cells expressed DAL-1 and MAL but not CADM1. This study revealed that MCPyV-negative MCCs significantly expressed higher CADM1 and lower MAL than MCPyV-positive MCCs; these expression levels were markedly related to unfavorable outcomes. These data will give us important insights to develop novel molecular target therapies for MCCs. Copyright © 2015 Elsevier Inc. All rights reserved.

  12. Efeito de ação educativa participativa no conhecimento de professores do ensino básico sobre malária

    Directory of Open Access Journals (Sweden)

    Martha Cecilia Suárez-Mutis

    2011-10-01

    Full Text Available OBJETIVO: Descrever uma estratégia educativa participativa de construção de conhecimentos relacionados à malária entre professores em um município altamente endêmico. MÉTODOS: Foi feito um estudo observacional. Um curso de 40 horas foi realizado sob enfoque multidisciplinar e problematizador para 46 professores, prioritariamente da área rural, no município de Barcelos, AM, em 2008. O processo educativo participativo incluiu oficinas e aulas práticas. Para investigar os conhecimentos, aplicou-se um questionário previamente validado, antes e após o curso, avaliado por abordagens quantitativa e qualitativa usando a análise temática para respostas abertas. RESULTADOS: Previamente ao curso, os professores tinham pouca informação sobre os mecanismos de transmissão, meios de prevenção e a associação da malária aos seus vetores, bem como conceitos restritos sobre saúde. Após o curso, não somente aumentou o conhecimento dos professores sobre a malária como também emergiram reflexões sobre o papel do professor na sociedade. CONCLUSÕES: O efeito da ação educativa na construção de um saber contextualizado sobre malária e saúde indica o potencial da estratégia desenvolvida. Processos de educação permanente são necessários à sustentabilidade dos novos saberes e práticas, orientados pela promoção da saúde.

  13. Geography, population, demography, socioeconomic, anthropometry, and environmental status in the MAL-ED cohort and case-control study Sites in Fortaleza, Ceará, Brazil.

    Science.gov (United States)

    Lima, Aldo A M; Oriá, Reinaldo B; Soares, Alberto M; Filho, José Q; de Sousa, Francisco; Abreu, Cláudia B; Bindá, Alexandre; Lima, Ila; Quetz, Josiane; Moraes, Milena; Maciel, Bruna; Costa, Hilda; Leite, Alvaro M; Lima, Noélia L; Mota, Francisco S; Di Moura, Alessandra; Scharf, Rebecca; Barrett, Leah; Guerrant, Richard L

    2014-11-01

    The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) cohort in the study's Fortaleza, Brazil, catchment area has a population of approximately 82 300 inhabitants. Most of the households (87%) have access to clean water, 98% have electricity, and 69% have access to improved toilet/sanitation. Most childbirths occur at the hospital, and the under-5 mortality rate is 20 per 1000 live births. The MAL-ED case-control study population, identified through the Institute for the Promotion of Nutrition and Human Development (IPREDE), serves 600 000 inhabitants from areas totaling about 42% of the city of Fortaleza. IPREDE receives referrals from throughout the state of Ceará for infant nutrition, and provides services including teaching activities and the training of graduate students and health professionals, while supporting research projects on child nutrition and health. In this article, we describe the geographic, demographic, socioeconomic, anthropometric, and environmental status of the MAL-ED cohort and case-control study populations in Fortaleza, Brazil. © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  14. Transglycosylation properties of maltodextrin glucosidase (MalZ) from Escherichia coli and its application for synthesis of a nigerose-containing oligosaccharide

    Energy Technology Data Exchange (ETDEWEB)

    Song, Kyung-Mo [Center for Agricultural Biomaterials and Department of Food Science and Biotechnology, Seoul National University, Seoul 151-921 (Korea, Republic of); Shim, Jae-Hoon [Department of Biology, University of Incheon, Incheon 406-772 (Korea, Republic of); Park, Jong-Tae; Kim, Sung-Hee [Center for Agricultural Biomaterials and Department of Food Science and Biotechnology, Seoul National University, Seoul 151-921 (Korea, Republic of); Kim, Young-Wan [Department of Food and Biotechnology, Korea University, Jochiwon 339-700 (Korea, Republic of); Boos, Winfried [Department of Biology, University of Konstanz, Konstanz 78457 (Germany); Park, Kwan-Hwa, E-mail: parkkh@incheon.ac.kr [Department of Biology, University of Incheon, Incheon 406-772 (Korea, Republic of)

    2010-06-18

    The transglycosylation reaction of maltodextrin glucosidase (MalZ) cloned and purified from Escherichia coli K12 was characterized and applied to the synthesis of branched oligosaccharides. Purified MalZ preferentially catalyzed the hydrolysis of maltodextrin, {gamma}-cyclodextrin (CD), and cycloamylose (CA). In addition, when the enzyme was incubated with 5% maltotriose (G3), a series of transfer products were produced. The resulting major transfer products, annotated as T1, T2, and T3, were purified and their structures were determined by TLC, MALDI-TOF/MS, {sup 13}C NMR, and enzymatic analysis. T1 was identified as a novel compound, maltosyl {alpha}-1,3-maltose, whereas T2 and T3 were determined to be isopanose and maltosyl-{alpha}-1,6-maltose, respectively. These results indicated that MalZ transferred sugar moiety mainly to C-3 or C-6-OH of glucose of the acceptor molecule. To obtain highly concentrated transfer products, the enzyme was reacted with 10% liquefied cornstarch, and then glucose and maltose were removed by immobilized yeast. The T1 content of the resulting reaction mixture reached 9.0%. The mixture of T1 containing a nigerose moiety can have an immunopotentiating effect on the human body and may be a potential functional sugar stuff.

  15. Gross Mal distribution Identification and Effect of Inlet Distributor on the Phase Holdup in a Trickle Bed Reactor Using Gamma-Ray Densitometry (GRD)

    International Nuclear Information System (INIS)

    Mohd Fitri Abdul Rahman; Alexander, V.; Al-Dahhan, M.

    2016-01-01

    Local liquid and gas mal distribution and their holdups in a packed column are difficult to identify due to multiphase properties and other design factors. Good liquid and gas flow distribution important to determine to get high performance of Trickle Bed Reactor (TBR). Gross mal distribution indicates some faulty or bad flow distribution of liquid and gas. In this work, gross mal distribution of phases has been identified using Gamma Ray Densitometry (GRD) technique with three types of inlet distributors (single inlet towards the wall, single inlet at the center, and proper shower) by measuring line average diameter profile of phases (Liquid, Gas, and Solids) holdups. Gamma-ray densitometry is a non-invasive technique which can be implemented at the laboratory, pilot plant, and industrial scales reactors. Experiments were performed on 0.14 m diameter reactor made of Plexiglas filled with 0.003 m glass bead which acts as the solid. The superficial velocities for both gas and liquid were in the range 0.03 m/s to 0.27 m/s and 0.004 m/s to 0.014 m/s respectively. Proper shower distributor showed early liquid spreading than compared with other distributors. The effect of superficial gas velocity on liquid spread was seen to be non-significant, and liquid distribution is found to be almost uniform at the center region of the catalyst bed. (author)

  16. A democracia no Brasil não é um mal-entendido = Democracy in Brazil is not a misunderstanding

    Directory of Open Access Journals (Sweden)

    Coelho, Maria Francisca Pinheiro

    2014-01-01

    Full Text Available A ideia deste trabalho surgiu da famosa frase de Sérgio Buarque de Holanda, em Raízes do Brasil: “A democracia no Brasil foi sempre um lamentável mal-entendido. ” Para o autor, inspirado nos tipos ideais weberianos e sob um olhar comparativo, o Brasil com seu homem cordial – aquele que age mais pelo coração do que pela razão – e com o predomínio do espaço privado sobre o público não se apresentava como um solo receptivo aos valores de igualdade da democracia. O texto pretende sugerir que a institucionalização das regras do jogo democrático relativiza o peso da cultura, sem, contudo, alterar seus traços no ritmo compatível com as mudanças das normas. O Brasil, com todos os problemas decorrentes de uma sociedade desigual e hierárquica, situa-se atualmente entre as democracias mais consolidadas da América Latina, que mais interagem e que apresentam disposição para o diálogo

  17. Surto de malária por Haemoproteus columbae em pombos An outbreak of malaria by Haemoproteus columbae in pigeons

    Directory of Open Access Journals (Sweden)

    J.S. Resende

    2001-06-01

    Full Text Available Relata-se um surto de malária por Haemoproteus columbae em pombos-correio (Columba livia, caracterizado por um quadro agudo com mortalidade de 3% ao dia em aves de aspecto saudável ou crônico com prostração e fraqueza. O exame clínico das aves doentes evidenciou sinusite e conjuntivite e à necropsia traqueíte hemorrágica, aerossaculite, esplenomegalia, nefromegalia e hepatomegalia com hemorragias. O díptero hematófago da família Hippoboscidae Pseudolynchia canariensis foi encontrado inserido entre as penas dos indivíduos. Esfregaços de sangue periférico e cardíaco e impressões de baço e fígado corados por Giemsa permitiram a visualização de inclusões intraeritrocitárias características de Haemoproteus columbae

  18. Instrumentação anterior da coluna em espondilite tuberculosa mal de pott: Relato de caso

    Directory of Open Access Journals (Sweden)

    Farage Luciano

    2002-01-01

    Full Text Available Relatamos caso de tratamento cirúrgico com instrumentação anterior em espondilite tuberculosa (mal de Pott, em mulher de 71 anos, que se encontrava em tratamento para tuberculose na forma pulmonar e evoluiu com dor lombar, dificuldade progressiva para deambular, cifose e disfunção vesical. A ressonância magnética revelou lesão nos corpos vertebrais de T12 e L1 com abcesso paravertebral. A paciente foi tratada cirurgicamente por acesso tóraco-abdominal lateral. Os corpos vertebrais foram ressecados, foi instalado uma gaiola vertical (mesh cage e a coluna foi estabilizada com placa lateral (Z plate e parafusos fixados em T11 e L2. Essa técnica permite boa artrodese dos corpos vertebrais remanescentes e boa estabilidade da coluna, sem comprometer a eficácia dos tuberculostáticos. A paciente foi avaliada um ano após a operação e não apresentava déficit motor, dor residual e a cifose foi desfeita.

  19. Malária no Brasil: panorama epidemiológico na última década

    Directory of Open Access Journals (Sweden)

    Barata Rita de Cássia B.

    1995-01-01

    Full Text Available Este artigo apresenta, de maneira resumida, as principais alterações que marcaram a ocorrência de malária, no Brasil, nesta última década. Chama-se a atenção para o processo de focalização da doença, com a concentração da transmissão em áreas, relativamente restritas, da região amazônica. A mudança na situação epidemiológica acarreta a revisãoconceitual, levando ao abandono da concepção de "doença de massa" e à elaboração da teoria focal. Do mesmo modo, as ações de controle sofrem os impactos das transformações ocorridas e as tentativas de erradicação são abandonadas e substituídas por medidas de controle diversificadas e adaptadas a cada localidade. As novas propostas, oriundas da Conferência Ministerial de Amsterdam, são apresentadas e comentadas.

  20. Uptake of health care services and health status of HIV-infected women diagnosed through antenatal HIV screening in Barbados, 1996-2004 Utilización de los servicios de atención sanitaria y estado de salud de las mujeres seropositivas al VIH diagnosticadas mediante el tamizaje prenatal para el VIH en Barbados, 1996-2004

    Directory of Open Access Journals (Sweden)

    Alok Kumar

    2007-12-01

    Full Text Available OBJECTIVES: To study utilization of HIV-related health care services and to describe the health status of HIV-infected women diagnosed through antenatal voluntary counseling and testing (VCT for HIV infection in Barbados. METHODS: This is a descriptive study. The study population includes all HIV-infected women in Barbados diagnosed as HIV-infected through VCT for HIV infection during 1996-2004. RESULTS: The median duration of HIV infection from time of diagnosis to the time of this report for the 163 women diagnosed during the study period was 72 months (low range, 9 months; high range, 117 months. Of the 163 women, 102 (62.6% had attended the centralized HIV/AIDS clinic for follow-up (care, treatment, and monitoring, whereas 61 (37.4% had never attended the clinic. The median time lag between diagnosis of HIV infection and first presentation to the HIV/AIDS clinic was 36 months (low range, 1 month; high range, 114 months. Of the HIV-infected women who attended the HIV/AIDS clinic, more than one-fourth had severe immunodeficiency at the time of their first follow-up visit. Of the 53 women undergoing highly active anti-retroviral therapy (HAART at the time of the study, 23 (43.4% began the therapy within three months of their first follow-up visit. CONCLUSIONS: Early HIV diagnosis through antenatal VCT is not enough to ensure that women with HIV will get adequate and timely HIV-related health care. These women suffer significant premature mortality, largely related to inadequate follow-up.OBJETIVOS: Estudiar la utilización de los servicios de atención sanitaria relacionados con el VIH y describir el estado de salud de las mujeres infectadas con este virus, diagnosticadas mediante el asesoramiento y la prueba de detección del VIH de carácter voluntario (APDV durante el período prenatal en Barbados. MÉTODOS: Este es un estudio descriptivo. La población de estudio abarcó a todas las mujeres infectadas por el VIH, diagnosticadas en Barbados

  1. Structural distortions in Sr3-xAxMO4F (A=Ca, Ba; M=Al, Ga, In) anti-Perovskites and corresponding changes in photoluminescence

    International Nuclear Information System (INIS)

    Sullivan, Eirin; Avdeev, Maxim; Vogt, Thomas

    2012-01-01

    The ordered oxyfluoride family Sr 3 − x A x MO 4 F (A=Ca, Ba and M=Al, Ga) has formed the basis of several new inorganic phosphors, and shows great potential for use in phosphor-conversion LED lamp devices. This study examines the correlation between subtle structural changes and photoluminescent behaviour in some of these materials. In order to ascertain whether cation charge compensation has any influence on structure and subsequent photoluminescent behaviour, a comparison was carried out between phases with the nominal compositions Sr 2.975 Ce 0.025 AlO 4 F and Sr 2.95 Ce 0.025 Na 0.025 AlO 4 F using structural characterisation based upon high-resolution neutron powder diffraction (NPD) data. Additionally, NPD data has been used to elucidate the role of different M cations in these materials, using Sr 2.25 Ba 0.6 Eu 0.1 M 0.95 In 0.05 O 4−α F 1−δ (M=Al, Ga) to determine the effect M cation size has on structure and photoluminescent properties. - Graphical abstract: The structure of Sr3-xAxMO4F (A=Ca, Ba and M=Al, Ga) and excitation and emission spectra for Sr 2.25 Ba 0.6 Eu 0.1 Ga 0.95 In 0.05 O 4−α F 1−δ . Highlights: ► Correlation between structural changes and photoluminescence in Sr 3−x A x MO 4 F (A=Ca, Ba, M=Al, Ga). ► Comparison of Sr 2.975 Ce 0.025 AlO 4 F and Sr 2.95 Ce 0.025 Na 0.025 AlO 4 F using high-resolution NPD. ► Study of the effect of cation charge-compensation on structure and photoluminescent behaviour. ► Examination of high-resolution NPD data for Sr 2.25 Ba 0.6 Eu 0.1 M 0.95 In 0.05 O 4−α F 1−δ (M=Al, Ga). ► Determination of the effect M cation size has on structure and photoluminescent properties.

  2. An ecosystem approach to malaria control in an urban setting Uma abordagem ecossistêmica ao controle da malária em contexto urbano

    Directory of Open Access Journals (Sweden)

    Gabriel Carrasquilla

    2001-01-01

    Full Text Available We conducted a research project aimed at strengthening local government and the community for a sustainable malaria control strategy. The project began with a baseline diagnosis of malaria prevalence, a KAP survey, entomology, and health services delivery, after which an epidemiological study was performed to identify risk factors associated with malaria, thereafter used to plan intervention measures. A program evaluation was conducted five years later. By using an ecosystem approach to reanalyze data, this paper discusses how malaria arises from a complex interaction of cultural, economic, ecological, social, and individual factors. Intervention measures require an intersectorial and transdisciplinary approach that does not exist at the moment. Health sector leadership is limited, and there is no true community participation. Implications for research, including the use of qualitative and quantitative methods, study design, and complexity of data analysis are discussed. Finally, implications for malaria control are discussed, stressing the differences between the ecosystem and integrated disease control approaches.Os autores implementaram um projeto de pesquisa voltado ao fortalecimento do governo local e da comunidade com vistas à estratégia sustentável de controle da malária. O projeto iniciou com diagnóstico prévio, incluindo prevalência da malária, entomologia, KAP (conhecimentos, atitudes e práticas e oferta de serviços de saúde; a seguir, realizou-se inquérito epidemiológico para identificar fatores de risco associados à malária e a escolha de medidas de intervenção adequadas. O programa foi avaliado após cinco anos. Ao adotar a abordagem ecossistêmica para re-analisar os dados, o artigo discute como a malária surge a partir da interação complexa entre fatores culturais, econômicos, ecológicos, sociais e individuais. Medidas de intervenção exigem abordagem intersetorial e transdisciplinar ainda não existente. A

  3. Sequential motor task (Luria's Fist-Edge-Palm Test in children with benign focal epilepsy of childhood with centrotemporal spikes Tarefa motora sequencial (Teste de Lúria punho-lado-palma em crianças com epilepsia focal benigna da infância com descarga centrotemporal

    Directory of Open Access Journals (Sweden)

    Carmen Silvia Molleis Galego Miziara

    2013-06-01

    Full Text Available This study evaluated the sequential motor manual actions in children with benign focal epilepsy of childhood with centrotemporal spikes (BECTS and compares the results with matched control group, through the application of Luria's fist-edge-palm test. The children with BECTS underwent interictal single photon emission computed tomography (SPECT and School Performance Test (SPT. Significant difference occurred between the study and control groups for manual motor action through three equal and three different movements. Children with lower school performance had higher error rate in the imitation of hand gestures. Another factor significantly associated with the failure was the abnormality in SPECT. Children with BECTS showed abnormalities in the test that evaluated manual motor programming/planning. This study may suggest that the functional changes related to epileptiform activity in rolandic region interfere with the executive function in children with BECTS.Esse estudo avaliou ações motoras manuais sequenciais em crianças com epilepsia focal benigna da infância com descarga centrotemporal (EBICT e comparou os resultados com o grupo controle pareado, através do teste de Lúria (punho-lado-palma. As crianças com EBICT realizaram single photon emission computed tomography (SPECT interictal e Teste de Desempenho Escolar (TDE. Foram encontradas diferenças significativas entre os dois grupos nas atividades motoras de três movimentos iguais e três movimentos diferentes. As crianças com piores resultados no TDE e com SPECT alterado apresentaram mais erros no teste de imitação manual. Crianças com epilepsia fracassaram nos testes de avaliação motora que envolvem programação/planejamento. Esse estudo sugere que mudanças funcionais relacionadas à atividade epileptiforme na região rolândica interfere com as funções executivas de crianças com EBICT.

  4. Comparison of histological and molecular diagnosis of Helicobacter pylori in benign lesions and gastric adenocarcinoma Comparação dos diagnósticos histológico e molecular do Helicobacter pylori em lesões benignas e adenocarcinomas gástricos

    Directory of Open Access Journals (Sweden)

    Ana Cristina Gobbo César

    2005-03-01

    comparar os resultados do diagnóstico histológico usado de rotina na detecção do H. pylori com o diagnóstico molecular. Foram utilizadas amostras de 80 lesões gástricas (gastrite crônica, gastrite atrófica, úlcera gástrica e metaplasia intestinal, 18 amostras de adenocarcinoma gástrico e 10 amostras de mucosa gástrica normal H. pylori negativas (controle. Todas as amostras foram avaliadas histologicamente (coloração com hematoxilina-eosina e Giemsa e pela PCR com a amplificação dos genes antígeno espécie-específico (H3H4 e urease A (H5H6 do H. pylori e pelo gene humano CYP1A1, como controle da qualidade do DNA. Nas amostras de lesão benigna e adenocarcinoma gástrico, a infecção foi detectada em 43% (42/98 e 71% (70/98, respectivamente, para os diagnósticos histológico e molecular (p = 0,0001. O teste de PCR detectou o H. pylori em 27,5% (22/80 das lesões gástricas benignas e em 50% (9/18 dos adenocarcinomas gástricos, com diagnóstico histológico negativo para essa bactéria. Cerca de 2,5% das amostras, exclusivamente de lesões benignas, com diagnóstico histológico positivo apresentaram resultado molecular negativo, para ambos os primers. Diferenças estatisticamente significantes foram encontradas entre os métodos histológico e molecular, em metaplasia intestinal (p = 0,0461 e adenocarcinoma gástrico (p = 0,0011, devido à subdetecção do H. pylori pelo método histológico, e provavelmente pela baixa densidade da bactéria conseqüente à atrofia severa da mucosa gástrica, nesses dois tipos de lesões. Nossos achados demonstram que o método de PCR é mais eficaz para diagnosticar a infecção por H. pylori, principalmente, em metaplasia intestinal e adenocarcinoma gástrico.

  5. «Gente de mal vivir»: families and incorrigible sons in new Spain, 1721-1729

    Directory of Open Access Journals (Sweden)

    Cáceres Menéndez, Beatriz

    2006-08-01

    Full Text Available Forced transportation to the Philippine and Mariana Islands, a form of social exile and the equivalent of deportation, was used in New Spain to punish criminals and people judged to be undesirable. Those who were sent across the Pacific were always male and usually American-born Spaniards. Both the viceregal government and parents thought forced transportation to be an appropriate way to rid Mexico not only of criminals but also of men «of evil living» - people whose lives were dedicated to gambling, public drunkenness, idleness, and immorality. Parents, brothers, and even wives therefore used forced transportation to eliminate unwanted family members whose behavior threatened to tarnish family honor.

    En la Nueva España el traslado forzoso de individuos a las Islas Filipinas y Marianas fue una forma de exilio equivalente a la deportación para castigar a los criminales y a la gente considerada indeseable. Los condenados fueron siempre hombres y usualmente españoles nacidos en América. Tanto el gobierno virreinal como los padres de familia pensaron en el traslado forzoso como un medio apropiado para limpiar el Reino no sólo de criminales sino también de «gente de mal vivir», es decir, aquellos dedicados al juego, la embriaguez pública, la ociosidad y la inmoralidad. Padres, hermanos y aún esposas utilizaron el traslado obligado como un medio para eliminar a los familiares cuyos comportamientos amenazaban manchar el honor de la familia.

  6. Cloning and Molecular Characterization of an Alpha-Glucosidase (MalH) from the Halophilic Archaeon Haloquadratum walsbyi.

    Science.gov (United States)

    Cuebas-Irizarry, Mara F; Irizarry-Caro, Ricardo A; López-Morales, Carol; Badillo-Rivera, Keyla M; Rodríguez-Minguela, Carlos M; Montalvo-Rodríguez, Rafael

    2017-11-21

    We report the heterologous expression and molecular characterization of the first extremely halophilic alpha-glucosidase (EC 3.2.1.20) from the archaeon Haloquadratum walsbyi . A 2349 bp region ( Hqrw_2071 ) from the Hqr. walsbyi C23 annotated genome was PCR-amplified and the resulting amplicon ligated into plasmid pET28b(+), expressed in E. coli Rosetta cells, and the resulting protein purified by Ni-NTA affinity chromatography. The recombinant protein showed an estimated molecular mass of 87 kDa, consistent with the expected value of the annotated protein, and an optimal activity for the hydrolysis of α-PNPG was detected at 40 °C, and at pH 6.0. Enzyme activity values were the highest in the presence of 3 M NaCl or 3-4 M KCl. However, specific activity values were two-fold higher in the presence of 3-4 M KCl when compared to NaCl suggesting a cytoplasmic localization. Phylogenetic analyses, with respect to other alpha-glucosidases from members of the class Halobacteria, showed that the Hqr. walsbyi MalH was most similar (up to 41%) to alpha-glucosidases and alpha-xylosidases of Halorubrum . Moreover, computational analyses for the detection of functional domains, active and catalytic sites, as well as 3D structural predictions revealed a close relationship with an E. coli YicI-like alpha-xylosidase of the GH31 family. However, the purified enzyme did not show alpha-xylosidase activity. This narrower substrate range indicates a discrepancy with annotations from different databases and the possibility of specific substrate adaptations of halophilic glucosidases due to high salinity. To our knowledge, this is the first report on the characterization of an alpha-glucosidase from the halophilic Archaea, which could serve as a new model to gain insights into carbon metabolism in this understudied microbial group.

  7. Cloning and Molecular Characterization of an Alpha-Glucosidase (MalH from the Halophilic Archaeon Haloquadratum walsbyi

    Directory of Open Access Journals (Sweden)

    Mara F. Cuebas-Irizarry

    2017-11-01

    Full Text Available We report the heterologous expression and molecular characterization of the first extremely halophilic alpha-glucosidase (EC 3.2.1.20 from the archaeon Haloquadratum walsbyi. A 2349 bp region (Hqrw_2071 from the Hqr. walsbyi C23 annotated genome was PCR-amplified and the resulting amplicon ligated into plasmid pET28b(+, expressed in E. coli Rosetta cells, and the resulting protein purified by Ni-NTA affinity chromatography. The recombinant protein showed an estimated molecular mass of 87 kDa, consistent with the expected value of the annotated protein, and an optimal activity for the hydrolysis of α-PNPG was detected at 40 °C, and at pH 6.0. Enzyme activity values were the highest in the presence of 3 M NaCl or 3–4 M KCl. However, specific activity values were two-fold higher in the presence of 3–4 M KCl when compared to NaCl suggesting a cytoplasmic localization. Phylogenetic analyses, with respect to other alpha-glucosidases from members of the class Halobacteria, showed that the Hqr. walsbyi MalH was most similar (up to 41% to alpha-glucosidases and alpha-xylosidases of Halorubrum. Moreover, computational analyses for the detection of functional domains, active and catalytic sites, as well as 3D structural predictions revealed a close relationship with an E. coli YicI-like alpha-xylosidase of the GH31 family. However, the purified enzyme did not show alpha-xylosidase activity. This narrower substrate range indicates a discrepancy with annotations from different databases and the possibility of specific substrate adaptations of halophilic glucosidases due to high salinity. To our knowledge, this is the first report on the characterization of an alpha-glucosidase from the halophilic Archaea, which could serve as a new model to gain insights into carbon metabolism in this understudied microbial group.

  8. La inclusión social por la vía del cuerpo en mujeres diagnosticadas con anorexia bulimia en la ciudad de Medellín, Colombia = Social inclusion through the body in women with anorexia-bulimia in Medellín, Colombia

    Directory of Open Access Journals (Sweden)

    Marín Cortés, Andrés Felipe

    2010-12-01

    Full Text Available Este informe presenta los hallazgos de la investigación "Narrativas identitarias sobre la vivencia corporal en mujeres diagnosticadas con trastorno de la alimentación" efectuada en Medellín.Objetivo: reconocer cómo el significado atribuido a la vivencia corporal devela la construcción de la identidad en mujeres con trastornos de la alimentación.Metodología: enfoque cualitativo, con diseño de casos múltiples analizados mediante los procedimientos del método fenomenológico-hermenéutico. Se hicieron entrevistas en profundidad y grupos focales. El estudio se ajustó a los principios éticos para la investigación en que participan seres humanos, incluyendo el consentimiento informado de cada una de las participantes.Resultados: 1 la evaluación que estas mujeres hacen de sí mismas está cruzada por la mirada de los otros; 2 existen contextos sociales de aparición que estimulan la anorexia-bulimia; 3 se hallaron tres formas de configuración de la anorexia-bulimia: estético-erótica, estéticoatlética y estético-afectiva; 4 la recuperación no consiste solamente en comer, sino también en permitir que el cuerpo se historice, es decir, que muestre en él las marcas del paso del tiempo.

  9. Efficacy and safety of 4 months of sublingual immunotherapy with recombinant Mal d 1 and Bet v 1 in patients with birch pollen-related apple allergy.

    Science.gov (United States)

    Kinaciyan, Tamar; Nagl, Birgit; Faustmann, Sandra; Frommlet, Florian; Kopp, Stephan; Wolkersdorfer, Martin; Wöhrl, Stefan; Bastl, Katharina; Huber, Hans; Berger, Uwe; Bohle, Barbara

    2018-03-01

    Birch pollen-related apple allergy is among the most prevalent food allergies in adolescent/adult subjects and mainly results from sensitization to the major birch pollen allergen Bet v 1 and subsequent cross-reaction with the apple protein Mal d 1. However, specific immunotherapy with birch pollen has inconsistent effects on apple allergy. We sought to compare the safety and efficacy of sublingual immunotherapy (SLIT) with 2 formulations containing either rMal d 1 or rBet v 1 on birch pollen-related apple allergy. Sixty participants with birch pollen-related apple allergy were randomized to daily sublingual application of placebo (n = 20) or 25 μg of rMal d 1 (n = 20) or rBet v 1 (n = 20) for 16 weeks. Adverse events were regularly recorded. Sublingual challenges with standardized doses of rMal d 1, skin prick tests with recombinant allergens, and measurements of allergen-specific IgE and IgG 4 antibodies were performed before and after treatment. Both formulations caused comparable, mainly local adverse events. No systemic reactions occurred. Compared with the placebo and rBet v 1-treated groups, SLIT with rMal d 1 reduced rMal d 1-induced oral symptoms (P = .001 and P = .038) accompanied by longitudinally reduced rMal d 1-specific cutaneous reactions (P = .022) and enhanced IgG 4 /IgE ratios (P = .012). SLIT with rBet v 1 neither improved the clinical reactivity to rMal d 1 nor enhanced rMal d 1-specific IgG 4 /IgE ratios. Participants receiving placebo showed no allergen-specific changes. Sublingual treatment with a recombinant food allergen was safe and clinically effective, as determined by using standardized challenges. We present a promising approach for the effective treatment of birch pollen-related apple allergy. Copyright © 2017 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

  10. MosquitoMap and the Mal-area calculator: new web tools to relate mosquito species distribution with vector borne disease.

    Science.gov (United States)

    Foley, Desmond H; Wilkerson, Richard C; Birney, Ian; Harrison, Stanley; Christensen, Jamie; Rueda, Leopoldo M

    2010-02-18

    Mosquitoes are important vectors of diseases but, in spite of various mosquito faunistic surveys globally, there is a need for a spatial online database of mosquito collection data and distribution summaries. Such a resource could provide entomologists with the results of previous mosquito surveys, and vector disease control workers, preventative medicine practitioners, and health planners with information relating mosquito distribution to vector-borne disease risk. A web application called MosquitoMap was constructed comprising mosquito collection point data stored in an ArcGIS 9.3 Server/SQL geodatabase that includes administrative area and vector species x country lookup tables. In addition to the layer containing mosquito collection points, other map layers were made available including environmental, and vector and pathogen/disease distribution layers. An application within MosquitoMap called the Mal-area calculator (MAC) was constructed to quantify the area of overlap, for any area of interest, of vector, human, and disease distribution models. Data standards for mosquito records were developed for MosquitoMap. MosquitoMap is a public domain web resource that maps and compares georeferenced mosquito collection points to other spatial information, in a geographical information system setting. The MAC quantifies the Mal-area, i.e. the area where it is theoretically possible for vector-borne disease transmission to occur, thus providing a useful decision tool where other disease information is limited. The Mal-area approach emphasizes the independent but cumulative contribution to disease risk of the vector species predicted present. MosquitoMap adds value to, and makes accessible, the results of past collecting efforts, as well as providing a template for other arthropod spatial databases.

  11. A computational fluid dynamics and effectiveness-NTU based co-simulation approach for flow mal-distribution analysis in microchannel heat exchanger headers

    International Nuclear Information System (INIS)

    Huang, Long; Lee, Moon Soo; Saleh, Khaled; Aute, Vikrant; Radermacher, Reinhard

    2014-01-01

    Refrigerant flow mal-distribution is a practical challenge in most microchannel heat exchangers (MCHXs) applications. Geometry design, uneven heat transfer and pressure drop in the different microchannel tubes are three main reasons leading to the flow mal-distribution. To efficiently and accurately account for these three effects, a new MCHX co-simulation approach is proposed in this paper. The proposed approach combines a detailed header simulation based on computational fluid dynamics (CFD) and a robust effectiveness-based finite volume tube-side heat transfer and refrigerant flow modeling tool. The co-simulation concept is demonstrated on a ten-tube MCHX case study. Gravity effect and uneven airflow effect were numerically analyzed using both water and condensing R134a as the working fluids. The approach was validated against experimental data for an automotive R134a condenser. The inlet header was cut open after the experimental data had been collected. The detailed header geometry was reproduced using the proposed CFD header model. Good prediction accuracy was achieved compared to the experimental data. The presented co-simulation approach is capable of predicting detailed refrigerant flow behavior while accurately predicts the overall heat exchanger performance. - Highlights: •MCHX header flow distribution is analyzed by a co-simulation approach. •The proposed method is capable of simulating both single-phase and two-phase flow. •An actual header geometry is reproduced in the CFD header model. •The modeling work is experimentally validated with good accuracy. •Gravity effect and air side mal-distribution are accounted for

  12. Sobre los saberes culturales y el fenómeno "sentirse bien-sentirse mal" On cultural knowledge and the phenomenon "feel good-fell bad"

    Directory of Open Access Journals (Sweden)

    Virtudes Rodero Sánchez

    2010-09-01

    Full Text Available El objetivo del presente estudio es identificar los saberes culturales inmersos en el fenómeno "sentirse-bien, sentirse mal", en diferentes situaciones de cuidado. Se elaboró un estudio cualitativo con un enfoque fenomenológico interpretativo, mediante el análisis de 18 narrativas a partir de entrevistas en profundidad realizadas por alumnas del Máster en Ciencias de la Enfermería en diferentes contextos de cuidados. Las categorías identificadas fueron: (1 Cronicidad y concepto de sentirse bien-sentirse mal. En la cronicidad este concepto está íntimamente relacionado con la recuperación de las actividades de la vida diaria y es componente importante en la percepción individual del concepto "calidad de vida". (2 Momentos agudos de enfermedad y concepto de sentirse bien-sentirse mal. En el análisis de los relatos del paciente aparecieron aspectos esenciales del fenómeno "sentirse bien-sentirse mal" para aumentar la comprensión de aspectos universales de algunos de sus componentes. Destacar que el fenómeno está íntimamente relacionado con la recuperación de las actividades de la vida diaria, y es un mediador importante en la percepción individual del concepto "calidad de vida". El interés de cara al cuidado es distinguir sus componentes universales, contextualizarlos en la práctica, dentro de las singularidades que presenta cada persona, de modo que nos permita su potenciación. El resultado es un cambio en la experiencia sentida.The object of the present study is to identify cultural knowledges immersed in the feeling-well, feeling-bad phenomenon in different care settings. A qualitative study was undertaken using a phenomenological interpretation approach through a meta-analysis of 18 narratives of profound interviews undertaken by Nursing Science Master Degree Students in different care situations. The categories established were: (1 Chronicity and the concept of feeling well-feeling bad. In this category, this concept is

  13. Sobre los saberes culturales y el fenómeno "sentirse bien-sentirse mal" On cultural knowledge and the phenomenon "feel good-fell bad"

    OpenAIRE

    Virtudes Rodero Sánchez; Carme Vives Relats; Sagrario Acebedo Urdiales; Carme Ferré Grau

    2010-01-01

    El objetivo del presente estudio es identificar los saberes culturales inmersos en el fenómeno "sentirse-bien, sentirse mal", en diferentes situaciones de cuidado. Se elaboró un estudio cualitativo con un enfoque fenomenológico interpretativo, mediante el análisis de 18 narrativas a partir de entrevistas en profundidad realizadas por alumnas del Máster en Ciencias de la Enfermería en diferentes contextos de cuidados. Las categorías identificadas fueron: (1) Cronicidad y concepto de sentirse b...

  14. Estudo de dose adequada da droga RO42-1611 (Arteflene) no tratamento da malária por Plasmodium falciparum

    OpenAIRE

    SILVA, Rita do Socorro Uchôa

    1997-01-01

    A resistência crescente do P. falciparum aos antimaláricos habitualmente empregados, torna urgente a avaliação de novas drogas. O Ro 42-1611 é um antimalárico derivado da planta chinesa Arlabotrys uncinatus. Usado apenas na África em três trabalhos no tratamento da malária por P. falciparum, tem sua ação desconhecida em sul-americanos com esta doença. Apesar do efeito antimalárico ter sido comprovado, ainda não se encontrou a dose adequada para o tratamento supressivo do P. falciparum. Avalia...

  15. Mal de Montaña, migraña y depresión: Coexistencia casual o causal? Posible rol de la hipoxia ambiental.

    Directory of Open Access Journals (Sweden)

    Alberto Arregui

    1995-10-01

    Full Text Available Objetivo: Estudiar la posible asociación entre mal de montaña crónico, migraña y depresión. Material y métodos: Estudio epidemiológico realizado en setiembre de 1990en 379 hombres adultos con residencia permanente en la ciudad de Cerro de Pasco (4300 m.s.n.m.; se hicieron 15 preguntas asociadas a depresión y 9 preguntas asociadas al mal de montaña crónico (MMC con las que se calcularon puntajes de depresión y del mal de montaña crónico. Los puntajes por encima de dos desviaciones estándar de la media fueron considerados como altos. Resultados: La frecuencia de migrañas fue de 48.3% entre hombres con puntajes altos de MMC y de 26.5% entre aquellos con puntajes normales (p=0.013. El 16.7% de hombres con puntaje alto de MMC tuvo puntaje alto de depresión mientras que sólo el 6.5% con puntaje normal de MMC tuvo puntaje alto de depresión (p=0.04. El riesgo de tener puntaje alto de depresión o de MMC fue más del doble entre hombres con migrañas comparados con hombres sin migrañas. La posibilidad de tener migraña o puntajes alto de MMC, fue tres veces mayor entre hombres con puntajes alto de depresión comparados con los que tuvieron puntajes de MMC más altos que aquellos sin cefaleas o con otros tipos de cefaleas. Conclusiones: Los datos muestran una coexistencia más que casual entre estas tres entidades clínicas. Se sugiere que un factor de riesgo común a las tres sea la hipoxia crónica que podría producir cambios neuroquímicos en el cerebro que explicaría, en parte, los síntomas de estos tres síndromes. Los datos también sugieren que los síntomas subjetivos que ocurren en el mal de montaña crónico son similares a los que ocurren en la depresión. (Rev Med Hered 1996; 6: 163-167.

  16. Synthesis, crystal structure and magnetic properties of [Cu(mal(abpt(H2O].3/2H2O and [Cu2(sq(abpt 2].2H2O (mal = malonate, sq = squarate, abpt = 4-amino-3,5-di-2-pyridyl-4H-1,2,4 triazole

    Directory of Open Access Journals (Sweden)

    Eno A. Ededet

    2011-04-01

    Full Text Available Two new mixed-ligand complexes of formula [Cu(mal(abpt(H2O].3/2H2O (1 and [Cu2(sq(abpt2].2H2O (2 [mal = malonate, abpt = 4-amino-3,5-di-2-pyridyl-4H-1,2,4 triazole and sq = squarate], have been prepared and characterized by X-ray crystal structure determination and magnetic studies. Complex 1 crystallizes in the monoclinic system, space group C2/c, with a = 14.0086(2 Å, b = 10.0980(2 Å, c = 25.630(4 Å; β = 97.5900(10 o, and Z = 8. Complex 2 crystallizes in the triclinic system, space group P-1 with a = 7.5696(15 Å, b = 8.4697(17 Å, c = 11.049(2 Å; β = 93.00(3o, α = 96.98(3, γ = 90.111(3 and Z = 1. Complex 1 consist of a neutral mononuclear [Cu(mal(abpt(H2O] unit and water molecule of crystallization in a distorted square pyramidal coordination sphere, while complex 2 is viewed as being made up of [Cu(sq(abpt2] units with the squarato ligand bridging the two copper(II cations. Variable temperature magnetic behaviour of the complexes reveals the existence of weak antiferromagnetic interaction for complex 1 and weak ferromagnetic intrachain interaction for complex 2.

  17. Malûliyet

    OpenAIRE

    Güçlü, Eda

    2014-01-01

    Bezmez, Dikmen. “Urban Citizenship, the Right to the City and Politics of Disability in Istanbul.” International Journal of Urban and Regional Research 37, no. 1 (January 2013): 93–114. Evcil, An. “Wheelchair Accessibility to Public Buildings in Istanbul.” Disability & Rehabilitation: Assistive Technology 4, no. 2 (March 2009): 76–85. Evcil, Nilay. “Designers’ Attitudes Towards Disabled People and the Compliance of Public Open Places: The Case of Istanbul.” European Planning Studies 18, no. 1...

  18. Effects of the substitution of iron for cobalt on the crystal and magnetic properties of PrCo4-xFexM (M=Al and Ga)

    International Nuclear Information System (INIS)

    Zlotea, C.; Isnard, O.

    2003-01-01

    We report on the structural and magnetic properties of PrCo 4-x Fe x M where x=0-4 and M=Al and Ga. The iron solubility limit in these phases is determined by means of X-ray diffraction and scanning electron microscopy. Our study confirms that single phase samples crystallizing in the CaCu 5 -type structure are stabilized for x 5 structure but with a slight preference for the 3g site. The saturation magnetization and the Curie temperature increase upon the iron substitution. The PrCo 4-x Fe x M compounds present spin reorientation transitions, whatever the substituting M and the Fe content. The substitution of iron for cobalt induces a significant increase of the spin reorientation temperature. Neutron and X-ray powder diffraction experiments as well as magnetic measurements are combined in order to clarify the effects of the presence of iron on the magnetocrystalline anisotropy and the spin reorientation transition. Finally, the magnetic phase diagrams of PrCo 4-x Fe x M (M=Al and Ga) have been determined in the whole ordered temperature range

  19. Reconciliación de Malí; mayo en Kidal, inflexión en la segunda fase del proceso

    Directory of Open Access Journals (Sweden)

    Juan Carlos Castilla

    2015-01-01

    Full Text Available La reconciliación es uno de los retos de la consolidación de la paz. El ejercicio de la soberanía por parte de las instituciones locales, puede originar diferencias con las organizaciones internacionales durante la transformación del conflicto. El desafío es coordinar estrategias y medidas en el tiempo. El proceso de reconciliación comenzó en Malí con un gobierno de transición. Durante el año 2014, el gobierno ha tratado de impulsar el proceso, en un contexto en el que se han reproducido los enfrentamientos tribales, se han dado nuevos choques entre el MNLA y las Fuerzas Armadas malíes, y dónde sigue influyendo la actividad terrorista yihadista. IBK se refirió a aspectos fundamentales para el futuro inmediato del proceso tras los acontecimientos de mayo en Kidal. Tras estos acontecimientos, las negociaciones de paz se desarrollan con la mediación argelina. La complementariedad entre la justicia nacional y la internacional será una de las claves, lo que a su vez puede interrelacionar con la potencial re-integración futura de excombatientes.

  20. Retardo no crescimento intrauterino, baixo peso ao nascer e prematuridade em recém-nascidos de grávidas com malária, na Colômbia

    Directory of Open Access Journals (Sweden)

    Alberto Tobón-Castaño

    2011-06-01

    Full Text Available INTRODUÇÃO: É frequente a associação da malária com complicações como prematuridade, retardo no crescimento intrauterino, baixo peso ao nascer e mortalidade infantil, efeitos pouco estudados em áreas hipoendêmicas para malaria. O objetivo deste estudo foi analisar a relação da malária gestacional com estes efeitos em recém-nascidosnuma região endêmica para malária na Colômbia, entre 1993 e 2007. MÉTODOS: Foram estudadas as características em 1.716 recém-nascidos num estudo de coorte. Fez-se seguimento em 394 gestantes com malária (27% por Plasmodium falciparum e 73% por P. vivax e 1.322 sem malária. RESULTADOS: Foi encontrada uma relação entre a exposição à malária na gestação e o risco maior de baixo peso ao nascer (RR = 1,37; 1,03-1,83, assim como estatura baixa (RR = 1,52; 1,25-1,85, retardo no crescimento intrauterino (RR = 1,29; 1,0-1,66 e prematuridade (RR = 1,68; 1,3-2,17. A frequência de nascimentos prematuros foi maior nas mães com malária por P. falciparum (77% que aquelas com P. vivax (RR = 1,77; IC 95%: 1,2-2,6. CONCLUSÕES: O baixo peso ao nascer e o retardo no crescimento foi associado com malária na gestação na Colômbia. A infecção por P. vivax foi relacionada com efeitos adversos sobre o recém-nascido, de modo semelhante em relação ao P. falciparum.

  1. Surto de malária induzida entre usuários de drogas injetáveis Outbreak of malaria among injectable-drug users

    Directory of Open Access Journals (Sweden)

    Luiz Carlos Barradas Barata

    1993-02-01

    Full Text Available Em julho de 1990, foi registrado na cidade de Bauru, Estado de São Paulo, Brasil, um surto de malária envolvendo usuários de cocaína injetável. Uma ampla investigação epidemiológica, conduzida de 19 de julho a 13 de setembro, revelou que pelo menos 119 pessoas estavam envolvidas no surto, uma vez que haviam compartilhado seringas e agulhas com um ou mais casos confirmados nos 3 meses anteriores à ocorrência. Cento e duas dessas pessoas foram localizadas e entrevistadas, e destas, 99 foram submetidas a exame de gota espessa e 91 a exames sorológicos para malária. Foram confirmados por exame hemoscópico 21 casos de malária por P. vivax, e 3 outros tiveram exame sorológico positivo para P. vivax. O controle da transmissão foi obtido fornecendo-se cloroquina aos envolvidos no surto, numa dose inicial de 10 comprimidos, seguida de doses supressivas semanais de 2 comprimidos até que fosse identificado o último comunicante. Amostras de soro coletadas na ocasião revelaram, ao lado da malária, uma alta prevalência de infecções pelo HIV (58% e pelo vírus da hepatite B (40%. Foram discutidas as dificuldades para o controle do surto e a possibilidade da malária vir a se tornar uma doença endêmica entre usuários de drogas injetáveis, no Estado de São Paulo.Five cases of malaria were detected among cocaine users by the local health service in Bauru, a city with a population of 260,000, located 324 km from S. Paulo, Brazil, during the first three weeks of July 1990. Autochthonous malaria had not occurred in Bauru since 1978, and all the five cases denied having recently traveled to endemic areas. An extensive epidemiologic survey conducted from July 19 to September 13 revealed that the 5 cases were in fact part of a malaria outbreak among endovenous drug users. Moreover, at least 114 other people, who had in the last three months shared syringes and needles with one or more proved cases, were also involved in the outbreak. One

  2. Malé osobnosti veľkých dejín – veľké osobnosti malých dejín IV. Príspevky k hudobnej regionalistike, Slovenské národné múzeum – Hudobné múzeum, Brämerova kúria, Bratislava 30. listopadu – 1. prosince 2017

    Czech Academy of Sciences Publication Activity Database

    Kachlík, Jan

    2018-01-01

    Roč. 55, č. 1 (2018), s. 102-104 ISSN 0018-7003. [Malé osobnosti veľkých dejín – veľké osobnosti malých dejín IV. Príspevky k hudobnej regionalistike. Bratislava, 30.11.2017-01.12.2017] Institutional support: RVO:68378076 Keywords : music ology * conference Subject RIV: AL - Art, Architecture, Cultural Heritage OBOR OECD: Performing arts studies ( Music ology, Theater science, Dramaturgy)

  3. Prospective analysis of clinician accuracy in the diagnosis of benign anorectal pathology: the value of clinical information Análisis prospectivo de la precisión diagnóstica en la patología anorrectal benigna: importancia de la información clínica

    Directory of Open Access Journals (Sweden)

    Jaime Jimeno

    2012-03-01

    Full Text Available Aim: the prevalence of anorectal disorders in general population is high. The aim of this study was to analyze the influence of clinical symptoms on diagnostic accuracy for benign anorectal pathology among different specialists and evaluate the relationship between diagnostic accuracy and years of professional experience. Methods: seven typical cases were selected. In a first interview, participants were shown images and asked to make a diagnosis. Afterwards, images with additional information (clinical symptoms were used. Two groups (group 1 = general surgeons and group 2 = medical specialists who attended emergency department completed both phases of the study to analyze the influence of clinical symptoms on the final diagnosis. Results: forty four specialists were interviewed. The percentage of participants making a correct diagnosis in groups 1 and 2, respectively, was as follows: case 1 (perianal abscess: 100 vs. 80.6%, (p = 0.157; case 2 (fissure: 92.3 vs. 51.6% (p = 0.015; case 3 (thrombosed hemorrhoid: 92.3 vs. 74.2% (p = 0.321; case 4 (anal condyloma: 100 vs. 87.1% (p = 0.302; case 5 (rectal prolapse: 100 vs. 83.9% (p = 0.301; case 6 (prolapsed hemorrhoid: 92.3 vs. 29% (p = 0.001, and case 7 (fistula: 100 vs. 67.7% (p = 0.021. There were significant differences in the number of correctly diagnosed cases between groups (p Objetivo: la prevalencia de los trastornos anorrectales benignos en la población general es alta. El objetivo de este estudio es analizar la influencia de los síntomas clínicos en la precisión diagnóstica de la patología benigna anorrectal entre los diferentes especialistas y evaluar la relación entre el diagnóstico de la enfermedad y los años de experiencia profesional entre los profesionales participantes. Pacientes y métodos: se seleccionaron 7 casos típicos. En una primera entrevista, se mostró a los participantes las imágenes clínicas de cada caso y se les pidió que formularan un diagn

  4. Malaria infection and the anthropological evolution Infecção por Malária e evolução antropológica

    Directory of Open Access Journals (Sweden)

    Sergio Sabbatani

    2010-03-01

    malária exerceu papel biológico chave, influenciando até o desenvolvimento antropológico. Os Plasmódios causadores da malária desenvolveram dois tipos de evolução, segundo um ponto de vista biológico, e filogenético. Em particular, os Plasmódios vivax, malariae, e ovale poderiam ter coevoluído com a espécie humana ou ter atingido esta durante as fases mais antigas da evolução do gênero HOMO. Por outro lado, o Plasmódio falciparum teria sido transmitido aos humanos por macacos num período mais recente, provavelmente entre o fim da Idade Mesolítica e o início da Neolítica. Os Autores mostram evidências biomoleculares, tanto diretas como indiretas, de infecção por malária, observada em indivíduos enterrados, reportando ao Mundo Antigo, e trazidas à luz no decorrer de escavações arqueológicas em alguns sítios relevantes Mediterrâneos. Nesta revisão da literatura, os autores organizam evidências modernas. Confirmam o papel da malária ao afetar a evolução das populações no Mediterrâneo. As pessoas que moram nas várias regiões do Mediterrâneo foram progressivamente influenciadas pela malária, ao longo do avanço desta doença. Além disso, as populações afetadas desenvolveram adaptações culturais, alimentares, e de comportamento, contribuindo para uma redução no risco da doença. Entretanto, pode ser que ambas modificações (as biológicas e as dos hábitos usadas pelos Plasmódios da malária, favoreceram a emergência de grupos de pessoas com maior resistência contra a malária. Todos estes fatores considerados reduziram o impacto demográfico, influenciando de uma maneira favorável o desenvolvimento em geral, e o crescimento da civilização.

  5. Nanotecnologia farmacêutica aplicada ao tratamento da malária Application of pharmaceutical nanotechnology to the treatment of malaria

    Directory of Open Access Journals (Sweden)

    Lúcio Figueira Pimentel

    2007-12-01

    Full Text Available Apesar do desenvolvimento tecnológico e científico, a malária permanece como um dos maiores problemas de saúde a serem combatidos. As estratégias modernas para o controle da doença prevêem ações conjuntas, como o combate do inseto vetor, diagnóstico rápido e preciso, garantia de terapêutica adequada, redução dos casos de resistência, além do desenvolvimento de novos agentes terapêuticos e vacina e através da otimização da ação de fármacos utilizados na atualidade. Os sistemas de liberação controlada de fármacos vêm recebendo atenção especial nesta área de pesquisa, com o desenvolvimento de estratégias para a veiculação de agentes bioativos e vacinas na forma de nanodispositivos tais como lipossomas, nanopartículas e micropartículas. Diversos nanossistemas já demonstraram eficácia na otimização de vacinas e quimioterápicos destinados ao controle da malária. Este artigo de revisão tem por objetivo avaliar o estado da arte na terapêutica da malária e demonstrar o potencial da nanotecnologia farmacêutica como ferramenta destinada ao combate da doença.In spite of living in a scientific and technological era, malaria continues to be one of the worldwide greatest health challenges. The state-of-the-art policy to keep malaria under control is expected to comprise joint-strategies, such as the vector control, fast diagnosis, therapeutic guarantee, resistance cutback, drug optimization and development of new therapeutic agents and vaccines. Nano and microcarrier systems have been receiving a special attention, including the development of strategies for carrying bioactive agents, vaccines through nanodevices, such as liposomes and nanoparticles, and microdevices, such as microparticles and microemulsions. Numerous nanosystems have already substantiated their effectiveness to optimize vaccines, insecticides, and chemotherapeutic agents applied to the control of malaria. This review is intended to explain the

  6. DNA hypermethylation and decreased mRNA expression of MAL, PRIMA1, PTGDR and SFRP1 in colorectal adenoma and cancer

    International Nuclear Information System (INIS)

    Kalmár, Alexandra; Péterfia, Bálint; Hollósi, Péter; Galamb, Orsolya; Spisák, Sándor; Wichmann, Barnabás; Bodor, András; Tóth, Kinga; Patai, Árpád V.; Valcz, Gábor; Nagy, Zsófia Brigitta; Kubák, Vivien; Tulassay, Zsolt; Kovalszky, Ilona; Molnár, Béla

    2015-01-01

    Colorectal cancer (CRC) development is accompanied by changes in expression for several genes; but the details of the underlying regulatory procesess remain unknown. Our aims were to assess the role of epigenetic processes in tumour formation and to identify characteristic DNA methylation and miRNA alterations in the colorectal adenoma-carcinoma sequence. Whole genome expression profiling was performed on colonic biopsy samples (49 healthy normal, 49 colorectal adenoma (AD), 49 CRC); on laser capture microdissected (LCM) epithelial and stromal cells from 6 CRC-normal adjacent tissue (NAT) samples pairs, and on demethylated human CRC cell lines using HGU133 Plus 2.0 microarrays (Affymetrix). Methylation status of genes with gradually altering expression along the AD-CRC sequence was further analysed on 10–10 macrodissected and 5–5 LCM samples from healthy colon, from adenoma and from CRC biopsy samples using bisulfite-sequencing PCR (BS-PCR) followed by pyrosequencing. In silico miRNA prediction for the selected genes was performed with miRWALK algorithm, miRNA expression was analysed on 3 CRC-NAT sample pairs and 3 adenoma tissue samples using the Human Panel I + II (Exiqon). SFRP1 immunohistochemistry experiments were performed. A set of transcripts (18 genes including MAL, SFRP1, SULT1A1, PRIMA1, PTGDR) showed decreasing expression (p < 0.01) in the biopsy samples along the adenoma-carcinoma sequence. Three of those (COL1A2, SFRP2, SOCS3) showed hypermethylation and THBS2 showed hypomethylation both in AD and in CRC samples compared to NAT, while BCL2, PRIMA1 and PTGDR showed hypermethylation only in the CRC group. miR-21 was found to be significantly (p < 0.01) upregulated in adenoma and tumour samples compared to the healthy colonic tissue controls and could explain the altered expression of genes for which DNA methylation changes do not appear to play role (e.g. BCL2, MAL, PTGS2). Demethylation treatment could upregulate gene expression of genes that were

  7. Algoritmo para monitoramento da incidência da malária na Amazônia brasileira, 2003 a 2010

    Directory of Open Access Journals (Sweden)

    Rui Moreira Braz

    2014-03-01

    Full Text Available OBJETIVO: Avaliar um algoritmo para detecção da variação da incidência da malária nos municípios da Amazônia brasileira. MÉTODOS: Avaliou-se um sistema de monitoramento automatizado, baseado em um algoritmo desenvolvido anteriormente pelos autores. O algoritmo utiliza o diagrama de controle por quartis para classificação dos municípios em quatro grupos, conforme a variação da incidência da malária: grupo 1 (redução da incidência-aqueles com incidência abaixo dos valores esperados; grupo 2 (incidência esperada-aqueles com incidência dentro dos valores esperados; grupo 3 (epidemia-aqueles com incidência acima dos valores esperados; grupo 4 (caso esporádico-aqueles com apenas um caso durante o ano. O período de análise foi de 2003 a 2010. Foram estudados todos os municípios existentes nos nove estados que compõem a Amazônia brasileira (805 municípios em 2003 e 807 a partir de 2004. RESULTADOS: Com base nessa metodologia, os municípios da região foram assim classificados: grupo 1, 152 municípios (18,8% da região em 2003 e 109 (13,5% em 2010; grupo 2, 206 (25,6% em 2003 e 331 (41,0% em 2010; grupo 3, 391 (48,6% em 2003 e 308 (38,2% em 2010; e grupo 4, 56 (7,0% em 2003 e 59 (7,3% em 2010. CONCLUSÕES: O algoritmo possibilitou verificar que, na Amazônia brasileira, o número de municípios com epidemias de malária em 2010 diminuiu em relação a 2003, enquanto o número de municípios com incidência esperada aumentou. No mesmo período, houve pouca variação no número de municípios com redução da incidência e daqueles com casos esporádicos.

  8. A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling.

    NARCIS (Netherlands)

    Nagpal, K.; Plantinga, T.S.; Wong, J.; Monks, B.G.; Gay, N.J.; Netea, M.G.; Fitzgerald, K.A.; Golenbock, D.

    2009-01-01

    The adapter protein MyD88 adapter-like (Mal), encoded by TIR-domain containing adapter protein (Tirap) (MIM 606252), is the most polymorphic of the five adapter proteins involved in Toll-like receptor signaling, harboring eight non-synonymous single nucleotide polymorphisms in its coding region. We

  9. Debata o památkové péči v 60. letech 20. století. Ivo Loos, Jindřich Malátek a Transgas

    Czech Academy of Sciences Publication Activity Database

    Švácha, Rostislav

    2017-01-01

    Roč. 77, č. 4 (2017), s. 361-372 ISSN 1210-5538 Institutional support: RVO:68378033 Keywords : Jindřich Malátek * Ivo Loos * postwar architecture * theory of architecture and heritage care * Transgas Subject RIV: AL - Art, Architecture, Cultural Heritage

  10. Realezas entre o bem e o mal: as representações de monarcas nas páginas da Marvel Comics

    OpenAIRE

    Guerra, Fábio Vieira

    2016-01-01

    Este trabalho propõe analisar três das monarquias apresentadas nas narrativas da editora americana de quadrinhos Marvel Comics. Essas histórias têm como protagonistas seres com habilidades extraordinárias chamados de super-heróis. Pautados em uma disputa dualista entre o Bem e o Mal, os quadrinhos de super-heróis são expressão de um imaginário coletivo sobre a nação estadunidense e os valores que norteiam sua organização social e suas ações no mundo. Desse modo, a representação de outros país...

  11. Pensamentos, sentimentos, vontades e afetos: a fisio-psicologia de Nietzsche a partir do aforismo 19 de Para Além de Bem e Mal

    Directory of Open Access Journals (Sweden)

    Bruno Martins Machado

    2011-05-01

    Full Text Available O presente estudo busca apresentar como a noçáo de fisio-psicologia proposta por Nietzsche se estrutura sobre o corpo e exige uma alteraçáo particular na determinaçáo da noçáo de vontade. Para realizar tal empreendimento, tomamos como parâmetro principalmente o aforismo 19 de Para Além de Bem e Mal. Neste texto, Nietzsche apresenta uma releitura da noçáo de vontade a partir da análise da estrutura dos afetos, dos pensamentos e dos sentimentos. A importância desse empreendimento se justifica por abrir espaço para uma proposta psicológica baseada em um dinamismo que está para além dos processos conscientes.

  12. Teste de hemaglutinação na sorologia da malária humana empregando hemácias parasitadas pelo Plasmodium berghei

    Directory of Open Access Journals (Sweden)

    Maria Carmen Arroyo Sanchez-Ruiz

    1985-06-01

    Full Text Available Foi padronizado um teste de hemaglutinação para a sorologia da malária humana, com reagente constituído de suspensão de hemácias de camundongos infectadas pelo Plasmodium berghei e preservadas por fixação aldeídica. Em pacientes com parasitemia por P. falciparum ou P. vivax obteve-se uma sensibilidade de 98,9% nos 88 casos estudados, o teste apresentando títulos entre 40 e 640. Para o grupo de 476 soros de indivíduos não-maláricos, obteve-se uma especificidade de 96,0%. O teste apresentou elevada reprodutibilidade, mesmo para diferentes lotes de antígenos. Nos 200 soros, obtidos ao acaso, de indivíduos de área endêmica, o teste apresentou positividade de 48,5%, contra 88,0% do teste de imunofluorescência-IgG. A baixa positividade pode ser devida a que o teste de hemaglutinação detecta anticorpos IgM. Após tratamento com 2-mercaptoetanol, todos os soros de pacientes com parasitemia tornaram-se não reagentes. Em relação ao teste de imunofluorescência-IgG, o teste de hemaglutinação apresentou índice de co-positívidade de 0,989 para os soros de maláricos com parasitemia. Para os soros de não-maláricos o teste de hemaglutinação apresentou índice de co-negatividade de 0,969. Por outro lado, no grupo de soros de área endêmica, o índice de co-positividade foi de 0,528 e o de co-negatividade, de 0,833.A hemagglutination test is described for human malaria serodiagnosis with aldehyde-fixed Plasmodium berghei infected mouse erythrocytes. In patients with a P. falciparum or P. vivax patent parasitemia positive results were seen in 98.9% ofthe 88 cases tested. Titres rangedfrom 40 to 640. A 96.0% specificity wasfoundfor 476 non-malarialpatients. A close reproducibility was observed forthe test, even for dijferent reagent batches. The test was positive in 48.5% of 200 residents in malaria endemic areas, taken at random. These subjects showed 88.0% positivity of the IgG-immunofluorescence test. This lower positivity for

  13. Causas mal definidas de morte e óbitos sem assistência Ill-defined causes of death and unattended deaths, Brazil, 2003

    Directory of Open Access Journals (Sweden)

    Augusto Hasiak Santo

    2008-02-01

    Full Text Available OBJETIVOS: Este trabalho estuda a distribuição dos óbitos por causas mal definidas no Brasil, no ano de 2003, entre as quais identifica a proporção de mortes sem assistência. MÉTODOS: Os dados provieram do Sistema de Informações Sobre Mortalidade, coordenado pelo Ministério da Saúde. As causas mal definidas de morte compreenderam as incluídas no "Capítulo XVIII - Sintomas, sinais e achados anormais de exames clínicos e de laboratório não classificados em outra parte" da Classificação Estatística Internacional de Doenças e Problemas Relacionados à Saúde, décima revisão, capítulo este no qual a categoria R98 identificava a "morte sem assistência". RESULTADOS: No Brasil, em 2003, a causa básica de 13,3% dos óbitos foi identificada como mal definida, sendo que as proporções maiores ocorreram nas Regiões Nordeste e Norte. Do total de causas mal definidas no país, 53,3% corresponderam a mortes sem assistência, proporção esta que superou 70% nos Estados do Maranhão, Piauí, Rio Grande do Norte, Pernambuco, Bahia, Paraíba e Alagoas. CONCLUSÃO: Dada a estrutura descentralizada para o levantamento dos óbitos no país, identifica-se a maior responsabilidade dos municípios e, em seguida, dos Estados para o aprimoramento da qualidade das estatísticas de mortalidade.BACKGROUND: We studied the distribution of deaths from ill-defined causes that occurred in Brazil during 2003, from which was identified the proportion of unattended deaths. METHODS: Data were obtained from the Mortality Information System, coordinated by the Ministry of Health. Causes of death included in "Chapter XVIII - Symptoms, signs and abnormal clinical and laboratory findings, not classified elsewhere" of the International Statistical Classification of Diseases and Related Health Problems, tenth revision, were considered ill-defined, among which the category R98 identified "unattended deaths". RESULTS: In Brazil during 2003 the underlying causes of

  14. Reposição cirúrgico-ortopédica de implante mal posicionado: relato de caso Surgical-orthopedic repositioning of malpositioned implant: a case report

    Directory of Open Access Journals (Sweden)

    Luiz Carlos Ferreira da Silva

    2005-06-01

    Full Text Available A reabilitação bucal por meio da colocação de implantes dentários tem se tornado um procedimento freqüente da clínica odontológica. Falhas no planejamento ou na execução da técnica podem levar a casos onde, apesar de osseointegrado, o implante não apresenta condições de restauração satisfatória devido ao seu mal posicionamento. Diversos autores têm relatado a possibilidade de se utilizar osteotomias segmentares de maxila ou mandíbula para reposicionar um segmento alveolar com implante, mostrando que esta pode ser uma técnica efetiva e previsível para restaurar implantes em posição anatômica comprometida. O presente trabalho apresenta o caso clínico de uma paciente de 20 anos de idade onde foi realizada osteotomia segmentar de maxila associada à distração osteogênica para correção de um implante mal posicionado.Oral rehabilitation through dental implants has become a common procedure at dental practice. However, if the implant is placed in an inappropriate position either because of inadequate presurgical planning or poor surgical technique, it may be unrestorable in spite of osseointegrated. Many authors have reported the possibility of using segmental maxillary or mandibular osteotomies to reposition an alveolar segment with its implants. This can be an effective, predictable technique for restoring implants in a compromised anatomic position. This paper presents a case report describing the use of this procedure associated to distraction osteogeneis to reposition one malpositioned implant in a 20 years old girl.

  15. Benign childhood epilepsy with centro-temporal spikes: correlation between clinical, cognitive and EEG aspects Epilepsia benigna da infância com pontas centrotemporais: correlação entre aspectos clínicos, eletrencefalográficos e cognitivos

    Directory of Open Access Journals (Sweden)

    Lineu Corrêa Fonseca

    2007-09-01

    Full Text Available Benign childhood epilepsy with centro-temporal spikes (BECTS is a form of epilepsy with no demonstrable anatomical lesion showing spontaneous seizure remission. During the active phase of the disease the children may show cognitive deficits. The objective of this study was to assess, in children with BECTS, the relationship between clinical-EEG aspects and performance in the school performance test (SPT, Raven's progressive matrixes test and the Wechsler Intelligence Scale for Children (WISC-III. Forty-two 7 to 11 year old children were included and the following tests carried out: anamnesis, neurological examination, electroencephalogram (EEG, SPT, Raven's test and WISC-III. The children with BECTS had normal IQ values but showed inferior performance in the SPT more frequently than "healthy" children, paired with respect to age and maternal scholastic level. There was moderate positive correlation between WISC-III results and the age when the seizures started and the educational level of the parents. On the other hand, aspects linked to the epileptic nature of BECTS, such as the number of seizures, time since last seizure and the number and lateralization of the centro-temporal spikes on the EEG, showed no correlation with the neuropsychological tests.A epilepsia benigna da infância com pontas centrotemporais (EBICT é uma forma de epilepsia na qual não existem lesões anatômicas demonstráveis e há remissão espontânea das crises. Na fase ativa da epilepsia as crianças podem apresentar déficits cognitivos. O objetivo deste estudo foi avaliar, em crianças com EBICT, a relação entre aspectos clínico-eletrencefalográficos e o desempenho no teste de desempenho escolar (TDE, no teste das matrizes progressivas de Raven e na Escala Wechsler de Inteligência para Crianças (WISC-III. Foram incluídas 42 crianças de 7 a 11 anos de idade. Foram realizados: anamnese, exame neurológico, eletrencefalograma (EEG, TDE, teste de Raven e WISC

  16. Intoxicações por plantas diagnosticadas em ruminantes e equinos e estimativa das perdas econômicas na Paraíba Plant poisonings diagnosed in ruminants and horses and estimation of the economical losses in Paraíba

    Directory of Open Access Journals (Sweden)

    Tales S. Assis

    2010-01-01

    Full Text Available Foi realizado um levantamento dos surtos de intoxicações por plantas em ruminantes e equinos diagnosticados no Laboratório de Patologia Veterinária (LPV, do Hospital Veterinário da Universidade Federal de Campina Grande, Campus de Patos, Paraíba, no período de 2000-2007. Em bovinos 7,4% dos diagnósticos realizados pelo LPV foram intoxicações por plantas. Foram diagnosticadas intoxicações por Centhraterum brachylepis (um surto, Brachiaria spp. (um surto, Crotalaria retusa (dois surtos, Ipomoea batatas (um surto, Marsdenia sp. (um surto, gramíneas contendo nitratos e nitritos (um surto por Echinochloa polystachya e dois surtos por Pennisetum purpureum, Palicourea aeneofusca (um surto, Prosopis juliflora (três surtos, Nerium oleander (um surto e Mimosa tenuiflora (sete surtos. Na espécie ovina 13% dos diagnósticos foram intoxicações por plantas. Os surtos foram causados por Ipomoea asarifolia (quatro surtos, Brachiaria spp. (três surtos, Crotalaria retusa (dois surtos, Tephrosia cinerea (dois surtos, Panicum dichotomiflorum (um surto, Mascagnia rigida (um surto e malformações associadas à ingestão de Mimosa tenuiflora (20 surtos. Nos caprinos, 6,4% dos diagnósticos corresponderam à intoxicação por plantas. Sete surtos foram causados por Mimosa tenuiflora, um por Ipomoea asarifolia, um por Ipomoea carnea, um por Ipomoea riedelli, três por Prosopis juliflora, um por Arrabidaea corallina, dois por Aspidosperma pyrifolium, dois por Turbina cordata e um por Opuntia ficus-indica. Na espécie equina 14% das doenças diagnosticadas foram devidas a intoxicações por plantas, sendo 12 surtos por Crotalaria retusa e um por Turbina cordata. As perdas na Paraíba por plantas tóxicas são estimadas em 3.895 bovinos, 8.374 ovinos, 6.390 caprinos e 366 equinos, que representam uma perda econômica anual, por morte de animais, de R$ 2.733.097,00. São relatados alguns aspectos epidemiológicos, sinais clínicos e patologia de surtos de

  17. Correction of vitamin D deficiency using sublingually administered vitamin D2 in a Crohn's disease patient with mal-absorption and a new ileostomy.

    Science.gov (United States)

    McCullough, Patrick; Heaney, Robert

    2017-10-01

    Vitamin D deficiency has been shown to be associated with many adverse health problems. Studies have shown that patients with Crohn's disease who have low vitamin D levels have a poorer quality of life than those with more adequate levels. It has also been shown that patients with mal-absorption problems have a difficult time achieving normal vitamin D levels in spite of aggressive supplementation, and that exposure to UVB radiation may be the most effective treatment option for these patients. We present a case in which 25-hydroxyvitamin D levels were normalized within 2 weeks in a severely vitamin D deficient patient with Crohn's disease with mal-absorption and a new ileostomy, utilizing sublingually administered vitamin D2. A 58 year-old white female was admitted with a new ileostomy following partial bowel resection due to complications from Crohn's disease. She was found to be severely vitamin D deficient at the time of admission, with a level of 6.1ng/ml on hospital day 3. Her treatment with vitamin D was delayed for a few days. She was initially treated with 5000 units of vitamin D3 orally twice a day for 3days (days 7-10). After discussion with the patient and obtaining her consent, vitamin D3 was stopped, and she was then treated with a total of 8 doses of 50,000 units of vitamin D2 administered sublingually. She was given the first 3 doses on alternating days (days 11, 13, 15), and then 5 more doses on consecutive days (days 17-21). The rise in her 25-hydroxyvitamin D level in response to treatment with sublingual vitamin D2 was significant. On day 10, after receiving 3days of orally administered vitamin D3, her level was 9.8ng/ml. One week later, after receiving 3 sublingual doses of vitamin D2, it rose to 20.3ng/ml. It was then measured on alternating days twice over the next 4days, and it rose to 45.5ng/ml, and then to 47.4ng/ml on the day of discharge to home. The major finding of this study is that sublingual administration of vitamin D2 appears to

  18. Mal de Pott en pediatría: presentación de 5 casos y revisión de la literatura

    Directory of Open Access Journals (Sweden)

    Gladys Abreu Suárez

    2002-09-01

    Full Text Available Se presentan 5 de los 6 niños afectados de mal de Pott en el período de 1995 a 2001, para una incidencia del 4,5 % del total de casos de tuberculosis infantil en Cuba. La mayoría de los niños tenía alrededor de 2 años de edad, con un predominio de la afectación lumbar en 4 pacientes. El cuadro clínico fue insidioso, y fueron más frecuentes el dolor de espalda y los trastornos a la marcha. El diagnóstico fue clinicorradiológico, y la tuberculina positiva en 4 niños. Sólo se aisló Micobacterium tuberculosis en un paciente, en el que concomitaban lesiones pulmonares. En 3 enfermos se hallaron abscesos paravertebrales (2 en la región dorsal, y el otro en el psoas. Aún se encuentran 3 pacientes en tratamiento; de los 2 curados, uno tiene pérdida de la lordosis fisiológica lumbar, y otro perdió un cuerpo vertebral con una giba residual ligera. Se concluye que, aunque la tuberculosis infantil no es un problema de salud en Cuba, y el mal de Pott no es frecuente, debe tenerse en cuenta ante un niño pequeño que se consulte con manifestaciones insidiosas de trastornos de la marcha y dolor de espalda.5 of the 6 children affected by Pott’s disease from 1995 to 2001 are presented in this paper for an incidence of 4.5 % of the total of cases of infantile tuberculosis in Cuba. Most of the children were about 2 years old. A predominance of lumbar affection was observed in 4 patients. The clinical picture was insidious and back pain and walking disorders were more frequent. The diagnosis was clinicoradiological and tuberculin was positive in 4 children. Micobacterium tuberculosis was only isolated from a patient with concomitant pulmonary injuries. Paravertebral abscesses (2 in the dorsal region and the other in the psoas were found in 3 patients. There are still 3 patients under treatment: one of the two that were cured suffers from loss of the physiological lumbar lordosis and the other lost a vertebral body and presents a mild residual

  19. Associação entre a contagem de linfócitos T CD4+ e a gravidade da neoplasia intra-epitelial cervical diagnosticada pela histopatologia em mulheres infectadas pelo HIV Association between CD4+ T-cell count and intraepithelial cervical neoplasia diagnosed by histopathology in HIV-infected women

    Directory of Open Access Journals (Sweden)

    Juliana Barroso Zimmermmann

    2006-06-01

    Full Text Available OBJETIVO: avaliar a associação entre a contagem de linfócitos T CD4+ e a gravidade da neoplasia intra-epitelial cervical em pacientes HIV positivas. MÉTODOS: estudo transversal no qual foram incluídas 87 pacientes infectadas pelo HIV, confirmado por testes sorológicos prévios. Todas eram portadoras do HPV cervical, diagnosticado por meio da reação em cadeia da polimerase. Foram realizados anamnese, exame físico e colposcopia de todas em pacientes. A biópsia do colo uterino foi realizada quando indicada pelo exame colposcópico. Os resultados histopatológicos foram classificados com neoplasia intra-epitelial de baixo grau (NIC I ou de alto grau (NIC II e II. A associação entre a contagem de linfócitos T CD4+ e a gravidade da lesão foi verificada por meio da comparação de médias utilizando a análise da variância (ANOVA. RESULTADOS: entre as 60 pacientes biopsiadas foram encontrados 24 casos (40,0% com NIC I, oito (13,3% NIC II, três (5% NIC III, 14 (23,3% pacientes somente com cervicite crônica e 11 (18,3% apresentando efeito citopático produzido pelo HPV, mas sem perda da polaridade celular. Isso equivale a 35 mulheres com lesão intra-epitelial de baixo grau (NIC I + HPV (58,3% e 11 (18,3% com lesão intra-epitelial de alto grau (NIC II + NIC III. A associação entre a média da contagem de linfócitos T CD4+ e a gravidade da lesão intra-epitelial cervical não foi significativa (p=0,901. CONCLUSÕES: não houve associação entre a contagem de linfócitos T CD4+ e a gravidade da lesão intra-epitelial do colo uterino, diagnosticada pelo exame histopatológico.PURPOSE: to evaluate association between CD4+ cell count and cervical intraepithelial lesion severity in HIV-infected women. METHODS: cross-sectional study of 87 HIV-infected patients which were confirmed by previous serologic examinations. All had cervical HPV diagnosed by polymerase chain reaction (PCR. All patients underwent anamnesis, physical examinations and

  20. Co-expression of the Thermotoga neapolitana aglB gene with an upstream 3'-coding fragment of the malG gene improves enzymatic characteristics of recombinant AglB cyclomaltodextrinase.

    Science.gov (United States)

    Lunina, Natalia A; Agafonova, Elena V; Chekanovskaya, Lyudmila A; Dvortsov, Igor A; Berezina, Oksana V; Shedova, Ekaterina N; Kostrov, Sergey V; Velikodvorskaya, Galina A

    2007-07-01

    A cluster of Thermotoga neapolitana genes participating in starch degradation includes the malG gene of sugar transport protein and the aglB gene of cyclomaltodextrinase. The start and stop codons of these genes share a common overlapping sequence, aTGAtg. Here, we compared properties of expression products of three different constructs with aglB from T. neapolitana. The first expression vector contained the aglB gene linked to an upstream 90-bp 3'-terminal region of the malG gene with the stop codon overlapping with the start codon of aglB. The second construct included the isolated coding sequence of aglB with two tandem potential start codons. The expression product of this construct in Escherichia coli had two tandem Met residues at its N terminus and was characterized by low thermostability and high tendency to aggregate. In contrast, co-expression of aglB and the 3'-terminal region of malG (the first construct) resulted in AglB with only one N-terminal Met residue and a much higher specific activity of cyclomaltodextrinase. Moreover, the enzyme expressed by such a construct was more thermostable and less prone to aggregation. The third construct was the same as the second one except that it contained only one ATG start codon. The product of its expression had kinetic and other properties similar to those of the enzyme with only one N-terminal Met residue.

  1. la originalidad del regionalismo castellano y leonés en 1931 y 1932. ¿Un proyecto genuino o la necesidad de asumir un mal menor?

    Directory of Open Access Journals (Sweden)

    Luis Felipe PALACIOS

    2016-05-01

    Full Text Available Entre 1931 y 1932, como ocurrió en otras regiones españolas, Castilla y León asistió al resurgir de un regionalismo que hasta la fecha apenas había dado síntomas de vitalidad. A partir de esta realidad la pregunta que surge es si la renovada actividad regionalista castellano y leonesa reflejaba la actualización de un sentir originario y bien arraigado o era una respuesta obligada por el avance que estaba logrando el catalanismo durante el período considerado y por el nuevo modelo de organización territorial del Estado que definió la nueva Constitución de 1931. A la vista del comportamiento y manifestaciones de las fuerzas políticas, sociales e institucionales castellano y leonesas, podemos concluir que el regionalismo castellano y leonés no respondió a un sentimiento genuino y propio sino que fue la consecuencia de la necesidad de asumir un mal menor, de la adaptación a un nuevo modelo territorial no deseado.

  2. In vivo subcellular localization of Mal de Rio Cuarto virus (MRCV) non-structural proteins in insect cells reveals their putative functions

    Energy Technology Data Exchange (ETDEWEB)

    Maroniche, Guillermo A.; Mongelli, Vanesa C.; Llauger, Gabriela; Alfonso, Victoria; Taboga, Oscar [Instituto de Biotecnologia, CICVyA, Instituto Nacional de Tecnologia Agropecuaria (IB-INTA), Las cabanas y Los Reseros s/n. Hurlingham Cp 1686, Buenos Aires (Argentina); Vas, Mariana del, E-mail: mdelvas@cnia.inta.gov.ar [Instituto de Biotecnologia, CICVyA, Instituto Nacional de Tecnologia Agropecuaria (IB-INTA), Las cabanas y Los Reseros s/n. Hurlingham Cp 1686, Buenos Aires (Argentina)

    2012-09-01

    The in vivo subcellular localization of Mal de Rio Cuarto virus (MRCV, Fijivirus, Reoviridae) non-structural proteins fused to GFP was analyzed by confocal microscopy. P5-1 showed a cytoplasmic vesicular-like distribution that was lost upon deleting its PDZ binding TKF motif, suggesting that P5-1 interacts with cellular PDZ proteins. P5-2 located at the nucleus and its nuclear import was affected by the deletion of its basic C-termini. P7-1 and P7-2 also entered the nucleus and therefore, along with P5-2, could function as regulators of host gene expression. P6 located in the cytoplasm and in perinuclear cloud-like inclusions, was driven to P9-1 viroplasm-like structures and co-localized with P7-2, P10 and {alpha}-tubulin, suggesting its involvement in viroplasm formation and viral intracellular movement. Finally, P9-2 was N-glycosylated and located at the plasma membrane in association with filopodia-like protrusions containing actin, suggesting a possible role in virus cell-to-cell movement and spread.

  3. Linfoma Nasal de Células T/Natural Killer Extranodal Refractario Mal Diagnosticado, Tratado de Manera Exitosa: Informe de Caso.

    Science.gov (United States)

    Saavedra Ramírez, José Domingo

    2017-01-01

    El linfoma de células T/natural killer extranodal ("extranodal natural killer/T-cell lymphoma", ENKL) nasal es un linfoma no Hodgkin (LNH) agresivo y poco común para el cual no se ha establecido un tratamiento de referencia claro, especialmente en el escenario de la enfermedad recidivante/refractaria. Debido a su rareza, no se han llevado a cabo ensayos aleatorizados específicamente en ENKL nasal; sin embargo, los informes de caso y las series de caso pequeñas ofrecen un conocimiento importante sobre nuevos tratamientos potenciales. Presentamos el informe de caso de un paciente con ENKL nasal (previamente mal diagnosticado como una sinusitis crónica recidivante) en quien la enfermedad progresó durante la quimioterapia con múltiples agentes pero respondió al tratamiento de segunda línea con pralatrexato como agente único. Analizamos opciones de tratamiento para el ENKL nasal recidivante/refractario y sugerimos que el pralatrexato se evalúe más a fondo en este escenario clínico.

  4. The etiology, risk factors, and interactions of enteric infections and malnutrition and the consequences for child health and development study (MAL-ED): description of the Tanzanian site.

    Science.gov (United States)

    Mduma, Estomih R; Gratz, Jean; Patil, Crystal; Matson, Kristine; Dakay, Mary; Liu, Sarah; Pascal, John; McQuillin, Lauren; Mighay, Emmanuel; Hinken, Elizabeth; Ernst, Alexandra; Amour, Caroline; Mvungi, Regisiana; Bayyo, Eliwaza; Zakaria, Yeconia; Kivuyo, Sokoine; Houpt, Eric R; Svensen, Erling

    2014-11-01

    The Haydom, Tanzania, site (TZH) of The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) Study is in north-central Tanzania, 300 km from the nearest urban center. TZH is in a remote rural district where most of the population are agropastoralists and grow maize as the staple food. The average household size is 7. The average woman achieves a parity of 6 and has 1 child death. Socioeconomic indicators are poor, with essentially no household having access to electricity, piped water, or improved sanitary facilities (compared with 14%, 7%, and 12%, respectively, reported nationally). The Demographic Health Survey Tanzania 2004 indicated that the region had high rates of stunting and underweight (40% and 31% of children aged child mortality rate of 5.8%. Human immunodeficiency virus prevalence among 18-month-old children is rural African population with profound poverty and malnutrition, but a strong community-based research infrastructure. © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  5. INTERVENCIÓN FAMILIAR PARA EL MANEJO PSICOLÓGICO EN PACIENTES ONCOLÓGICOS CON MAL PRONÓSTICO EN EL HOSPITAL DE LA MISERICORDIA

    Directory of Open Access Journals (Sweden)

    Martha Restrepo Forero

    2004-06-01

    Full Text Available Se diseñó un programa fundamentado en el modelo cognitivo conductual de Inoculación de Estrés e intervención en duelo anticipatorio basado en cuatro tareas. El programa fue aplicado a tres pacientes con mal pronóstico del Servicio de Oncohematología del Hospital de la Misericordia y a sus familias. Por medio de estudio de caso, se describieron factores de riesgo y de protección así como respuestas frente a dicha intervención. El análisis cualitativo de casos arrojó la descripción de respuestas a pérdidas previas no elaboradas, pautas de comunicación deficiente en uno de los casos, y reconocimiento de apoyo al interior de cada familia. Según el reporte de los participantes, la intervención permitió la expresión de sentimientos, la reflexión sobre el sentido de la vida, incremento de posibilidades y habilidades de comunicación y orientación hacia la solución de problemas y toma de decisiones.

  6. Caminhos de um mal-estar de civilização: reflexões intelectuais norte-americanas para pensar a democracia e o negro no Brasil

    Directory of Open Access Journals (Sweden)

    Elizabeth Cancelli

    2010-05-01

    Full Text Available

    Este trabalho tem como objetivo buscar eixos de reflexão desenvolvidos nos Estados Unidos e que foram importantes para repensar a questão da democracia e da cultura no Brasil, especialmente no que diz respeito à inclusão social do negro e à construção de uma identidade brasileira. Assim, as releituras da herança da escravidão verificadas no Sul norte-americano nas primeiras décadas do século XX e o encorajamento para a redefinição da democracia, ocorridos no auge da guerra fria e da cultural war, serão contemplados para a recuperação de vertentes importantes do pensamento brasileiro e sua inserção nos debates em torno desse “mal-estar de civilização”.

  7. Mal de Río Cuarto Virus Infection Triggers the Production of Distinctive Viral-Derived siRNA Profiles in Wheat and Its Planthopper Vector.

    Science.gov (United States)

    de Haro, Luis A; Dumón, Analía D; Mattio, María F; Argüello Caro, Evangelina Beatriz; Llauger, Gabriela; Zavallo, Diego; Blanc, Hervé; Mongelli, Vanesa C; Truol, Graciela; Saleh, María-Carla; Asurmendi, Sebastián; Del Vas, Mariana

    2017-01-01

    Plant reoviruses are able to multiply in gramineae plants and delphacid vectors encountering different defense strategies with unique features. This study aims to comparatively assess alterations of small RNA (sRNA) populations in both hosts upon virus infection. For this purpose, we characterized the sRNA profiles of wheat and planthopper vectors infected by Mal de Río Cuarto virus (MRCV, Fijivirus, Reoviridae ) and quantified virus genome segments by quantitative reverse transcription PCR We provide evidence that plant and insect silencing machineries differentially recognize the viral genome, thus giving rise to distinct profiles of virus-derived small interfering RNAs (vsiRNAs). In plants, most of the virus genome segments were targeted preferentially within their upstream sequences and vsiRNAs mapped with higher density to the smaller genome segments than to the medium or larger ones. This tendency, however, was not observed in insects. In both hosts, vsiRNAs were equally derived from sense and antisense RNA strands and the differences in vsiRNAs accumulation did not correlate with mRNAs accumulation. We also established that the piwi-interacting RNA (piRNA) pathway was active in the delphacid vector but, contrary to what is observed in virus-infected mosquitoes, virus-specific piRNAs were not detected. This work contributes to the understanding of the silencing response in insect and plant hosts.

  8. Oral and maxillofacial biopsied lesions in Brazilian pediatric patients: a 16-year retrospective study = Biópsias de lesões orais e maxilo-faciais em pacientes pediátricos brasileiros: estudo retrospectivo de 16 anos

    Directory of Open Access Journals (Sweden)

    Mouchrek, Monique Maria Melo

    2011-01-01

    Conclusão: Este estudo mostra uma tendência semelhante à relatada em estudos anteriores sobre as lesões mais freqüentes na região oral e maxilo-facial na população pediátrica. A maioria das lesões detectadas foram benignas, enquanto as malignas foram diagnosticadas em um número muito reduzido de pacientes

  9. Transmisión del Mal de Río Cuarto virus por ninfas de primer y tercer estadio de Delphacodes kuscheli Transmission of Mal de Río Cuarto virus by first and third-instar nymphs of Delphacodes kuscheli

    Directory of Open Access Journals (Sweden)

    Joel Arneodo

    2005-02-01

    Full Text Available Se comparó la capacidad de ninfas de primer y tercer estadío de Delphacodes kuscheli Fennah (Hemiptera: Delphacidae para adquirir y posteriormente transmitir el Mal de Río Cuarto virus (MRCV, bajo condiciones controladas. Ninfas I y III avirulíferas se alimentaron separadamente de plantas de trigo infectadas durante 48 horas, para luego ser colocadas en subgrupos de tres individuos sobre plantas de trigo sanas. Se realizaron transmisiones seriales utilizando períodos de inoculación de 24 horas. Ambos estadií os lograron adquirir y transmitir el MRCV, pero se evidenció una mayor cantidad de subgrupos infectivos cuando la adquisición se efectuó como ninfas I, así como una disminución significativa en la duración del período de latencia del virus respecto de los insectos que adquirieron el MRCV durante el tercer estadio ninfal.The ability of first and third-instar Delphacodes kuscheli Fennah (Hemiptera: Delphacidae nymphs to acquire and transmit Mal de Río Cuarto virus (MRCV, under controlled conditions, was investigated. First and third-instar nymphs were allowed acquisition feeding separately on infected wheat plants for 48 hours. The insects were then placed in groups of three for serial transmissions to healthy wheat plants, using inoculation periods of 24 hours. Both instars of D. kuscheli were demonstrated to acquire and subsequently transmit the virus. Nevertheless, transmission trials showed highest transmission efficiency and shortest latent period when MRCV was acquired by first-instar nymphs.

  10. Dynamics and Trends in Fecal Biomarkers of Gut Function in Children from 1–24 Months in the MAL-ED Study

    Science.gov (United States)

    McCormick, Benjamin J. J.; Lee, Gwenyth O.; Seidman, Jessica C.; Haque, Rashidul; Mondal, Dinesh; Quetz, Josiane; Lima, Aldo A. M.; Babji, Sudhir; Kang, Gagandeep; Shrestha, Sanjaya K.; Mason, Carl J.; Qureshi, Shahida; Bhutta, Zulfiqar A.; Olortegui, Maribel Paredes; Yori, Pablo Peñataro; Samie, Amidou; Bessong, Pascal; Amour, Caroline; Mduma, Estomih; Patil, Crystal L.; Guerrant, Richard L.; Lang, Dennis R.; Gottlieb, Michael; Caulfield, Laura E.; Kosek, Margaret N.

    2017-01-01

    Growth and development shortfalls that are disproportionately prevalent in children living in poor environmental conditions are postulated to result, at least in part, from abnormal gut function. Using data from The Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) longitudinal cohort study, we examine biomarkers of gut inflammation and permeability in relation to environmental exposures and feeding practices. Trends in the concentrations of three biomarkers, myeloperoxidase (MPO), neopterin (NEO), and α-1-antitrypsin (AAT), are described from fecal samples collected during the first 2 years of each child's life. A total of 22,846 stool samples were processed during the longitudinal sampling of 2,076 children 0–24 months of age. Linear mixed models were constructed to examine the relationship between biomarker concentrations and recent food intake, symptoms of illness, concurrent enteropathogen infection, and socioeconomic status. Average concentrations of MPO, NEO, and AAT were considerably higher than published references for healthy adults. The concentration of each biomarker tended to decrease over the first 2 years of life and was highly variable between samples from each individual child. Both MPO and AAT were significantly elevated by recent breast milk intake. All three biomarkers were associated with pathogen presence, although the strength and direction varied by pathogen. The interpretation of biomarker concentrations is subject to the context of their collection. Herein, we identify that common factors (age, breast milk, and enteric infection) influence the concentration of these biomarkers. Within the context of low- and middle-income communities, we observe concentrations that indicate gut abnormalities, but more appropriate reference standards are needed. PMID:27994110

  11. Malófagos (Phthiraptera, Amblycera, Ischnocera em aves cativas no sudeste do Brasil Chewing lice (Phthiraptera, Amblycera, Ischnocera on captive birds in southeastern Brazil

    Directory of Open Access Journals (Sweden)

    Salete Oliveira da Silva

    2009-01-01

    Full Text Available Foram identificadas 12 espécies de malófagos no Parque Zoológico Municipal Quinzinho de Barros, Sorocaba e Fundação Jardim Zoológico, Rio de Janeiro. Ciconiphilus pectiniventris em Cygnus atratus (Anseriformes, Anatidae; Kurodaia sp. em Buteo albicaudatus (Falconiformes, Accipitridae; Degeeriella sp. em Falco sparverius (Falconiformes, Falconidae; Colpocephalum sp. e Goniocotes parviceps em Pavo cristatus (Galliformes, Phasianidae; Goniodes pavonis em Rhea americana (Rheiformes, Rheidae; Colpocephalum cristatae e Heptapsogaster sp. em Cariama cristata (Gruiformes, Cariamidae; Austrophilopterus cancellosus em Ramphastos dicolorus (Piciformes, Ramphastidae; Strigiphilus crucigerus em Otus choliba (Strigiformes, Strigidae; Kurodaia sp. em Rhinoptynx clamator (Strigiformes, Strigidae e Colpocephalum pectinatum em Speotyto cunicularia (Strigiformes, Strigidae. As relações parasito hospedeiros em Strigiformes são novas no Brasil.Twelve chewing lice species were identified in Parque Zoológico Municipal Quinzinho de Barros, Sorocaba and Fundação Jardim Zoológico, Rio de Janeiro. The parasites found were: Ciconiphilus pectiniventris in Cygnus atratus (Anseriformes, Anatidae; Kurodaia sp. in Buteo albicaudatus (Falconiformes, Accipitridae; Degeeriella sp. in Falco sparverius (Falconiformes, Falconidae; Colpocephalum sp. and Goniocotes parviceps in Pavo cristatus (Galliformes, Phasianidae; Goniodes pavonis in Rhea americana (Rheiformes, Rheidae; Colpocephalum cristatae and Heptapsogaster sp. in Cariama cristata (Gruiformes, Cariamidae; Austrophilopterus cancellosus in Ramphastos dicolorus (Piciformes, Ramphastidae; Strigiphilus crucigerus in Otus choliba (Strigiformes, Strigidae; Kurodaia sp. in Rhinoptynx clamator (Strigiformes, Strigidae and Colpocephalum pectinatum in Speotyto cunicularia (Strigiformes, Strigidae. The host-lice relationships are new in Strigiformes in Brazil.

  12. Avaliação da eficácia do artesunato associado à tetraciclina na terapêutica da malária falciparum

    Directory of Open Access Journals (Sweden)

    Villalobos Salcedo Juan Miguel

    1997-01-01

    Full Text Available Realizou-se um ensaio clínico, randomizado e controlado, comparando o artesunato com o quinino e a mefloquina, em casos de malária não grave. Foram tratados 42 pacientes em regime de internação e o seguimento durou 28 dias. Realizou-se exame de gota espessa cada 12 horas até sua negativação, hemograma e bioquímica sanguínea, pré e pós-tratamento. A média da parasitemia inicial foi 42.568 parasitas/ml. Vinte e seis pacientes foram acompanhados durante 28 dias e 16 durante menos de 28 dias. Um paciente de cada grupo apresentou R I tardia e um paciente do grupo do quinino apresentou R III. As porcentagens de cura foram 88,8%, 85,7% e 81,8% para o artesunato, a mefloquina e o quinino, respectivamente, sem mostrar diferença significativa. O tempo de desaparecimento da febre não mostrou diferença significativa entre os grupos. O grupo do artesunato teve um tempo menor de clareamento da parasitemia (37,33 ± 11,52 horas quando comparado com o quinino (65,25 ± 17,44 horas, sendo estatisticamente significativa (p = 0,0016. O grupo da mefloquina (58,9 ± 16,68 horas não mostrou diferença com os outros grupos. Não se apresentaram efeitos adversos importantes em nenhum dos esquemas usados, sendo bem tolerados pelos pacientes.

  13. Reorganization of the actin cytoskeleton via transcriptional regulation of cytoskeletal/focal adhesion genes by myocardin-related transcription factors (MRTFs/MAL/MKLs)

    International Nuclear Information System (INIS)

    Morita, Tsuyoshi; Mayanagi, Taira; Sobue, Kenji

    2007-01-01

    RhoA is a crucial regulator of stress fiber and focal adhesion formation through the activation of actin nucleation and polymerization. It also regulates the nuclear translocation of myocardin-related transcription factor-A and -B (MRTF-A/B, MAL or MKL 1/2), which are co-activators of serum response factor (SRF). In dominant-negative MRTF-A (DN-MRTF-A)-expressing NIH 3T3 cell lines, the expressions of several cytoskeletal/focal adhesion genes were down-regulated, and the formation of stress fiber and focal adhesion was severely diminished. MRTF-A/B-knockdown cells also exhibited such cytoskeletal defects. In reporter assays, both RhoA and MRTF-A enhanced promoter activities of these genes in a CArG-box-dependent manner, and DN-MRTF-A inhibited the RhoA-mediated activation of these promoters. In dominant-negative RhoA (RhoA-N19)-expressing NIH 3T3 cell lines, the nuclear translocation of MRTF-A/B was predominantly prevented, resulting in the reduced expression of cytoskeletal/focal adhesion proteins. Further, constitutive-active MRTF-A/B increased the expression of endogenous cytoskeletal/focal adhesion proteins, and thereby rescued the defective phenotype of stress fibers and focal adhesions in RhoA-N19 expressing cells. These results indicate that MRTF-A/B act as pivotal mediators of stress fiber and focal adhesion formation via the transcriptional regulation of a subset of cytoskeletal/focal adhesion genes

  14. Epidemiology and Impact of Campylobacter Infection in Children in 8 Low-Resource Settings: Results From the MAL-ED Study.

    Science.gov (United States)

    Amour, Caroline; Gratz, Jean; Mduma, Estomih; Svensen, Erling; Rogawski, Elizabeth T; McGrath, Monica; Seidman, Jessica C; McCormick, Benjamin J J; Shrestha, Sanjaya; Samie, Amidou; Mahfuz, Mustafa; Qureshi, Shahida; Hotwani, Aneeta; Babji, Sudhir; Trigoso, Dixner Rengifo; Lima, Aldo A M; Bodhidatta, Ladaporn; Bessong, Pascal; Ahmed, Tahmeed; Shakoor, Sadia; Kang, Gagandeep; Kosek, Margaret; Guerrant, Richard L; Lang, Dennis; Gottlieb, Michael; Houpt, Eric R; Platts-Mills, James A

    2016-11-01

     Enteropathogen infections have been associated with enteric dysfunction and impaired growth in children in low-resource settings. In a multisite birth cohort study (MAL-ED), we describe the epidemiology and impact of Campylobacter infection in the first 2 years of life.  Children were actively followed up until 24 months of age. Diarrheal and nondiarrheal stool samples were collected and tested by enzyme immunoassay for Campylobacter Stool and blood samples were assayed for markers of intestinal permeability and inflammation.  A total of 1892 children had 7601 diarrheal and 26 267 nondiarrheal stool samples tested for Campylobacter We describe a high prevalence of infection, with most children (n = 1606; 84.9%) having a Campylobacter-positive stool sample by 1 year of age. Factors associated with a reduced risk of Campylobacter detection included exclusive breastfeeding (risk ratio, 0.57; 95% confidence interval, .47-.67), treatment of drinking water (0.76; 0.70-0.83), access to an improved latrine (0.89; 0.82-0.97), and recent macrolide antibiotic use (0.68; 0.63-0.74). A high Campylobacter burden was associated with a lower length-for-age Z score at 24 months (-1.82; 95% confidence interval, -1.94 to -1.70) compared with a low burden (-1.49; -1.60 to -1.38). This association was robust to confounders and consistent across sites. Campylobacter infection was also associated with increased intestinal permeability and intestinal and systemic inflammation.  Campylobacter was prevalent across diverse settings and associated with growth shortfalls. Promotion of exclusive breastfeeding, drinking water treatment, improved latrines, and targeted antibiotic treatment may reduce the burden of Campylobacter infection and improve growth in children in these settings. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America.

  15. Dynamics and Trends in Fecal Biomarkers of Gut Function in Children from 1-24 Months in the MAL-ED Study.

    Science.gov (United States)

    McCormick, Benjamin J J; Lee, Gwenyth O; Seidman, Jessica C; Haque, Rashidul; Mondal, Dinesh; Quetz, Josiane; Lima, Aldo A M; Babji, Sudhir; Kang, Gagandeep; Shrestha, Sanjaya K; Mason, Carl J; Qureshi, Shahida; Bhutta, Zulfiqar A; Olortegui, Maribel Paredes; Yori, Pablo Peñataro; Samie, Amidou; Bessong, Pascal; Amour, Caroline; Mduma, Estomih; Patil, Crystal L; Guerrant, Richard L; Lang, Dennis R; Gottlieb, Michael; Caulfield, Laura E; Kosek, Margaret N

    2017-02-08

    Growth and development shortfalls that are disproportionately prevalent in children living in poor environmental conditions are postulated to result, at least in part, from abnormal gut function. Using data from The Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) longitudinal cohort study, we examine biomarkers of gut inflammation and permeability in relation to environmental exposures and feeding practices. Trends in the concentrations of three biomarkers, myeloperoxidase (MPO), neopterin (NEO), and α-1-antitrypsin (AAT), are described from fecal samples collected during the first 2 years of each child's life. A total of 22,846 stool samples were processed during the longitudinal sampling of 2,076 children 0-24 months of age. Linear mixed models were constructed to examine the relationship between biomarker concentrations and recent food intake, symptoms of illness, concurrent enteropathogen infection, and socioeconomic status. Average concentrations of MPO, NEO, and AAT were considerably higher than published references for healthy adults. The concentration of each biomarker tended to decrease over the first 2 years of life and was highly variable between samples from each individual child. Both MPO and AAT were significantly elevated by recent breast milk intake. All three biomarkers were associated with pathogen presence, although the strength and direction varied by pathogen. The interpretation of biomarker concentrations is subject to the context of their collection. Herein, we identify that common factors (age, breast milk, and enteric infection) influence the concentration of these biomarkers. Within the context of low- and middle-income communities, we observe concentrations that indicate gut abnormalities, but more appropriate reference standards are needed. © The American Society of Tropical Medicine and Hygiene.

  16. Hydrogenation-disproportionation-desorption-recombination in Sm2Fe16M (M=Al, Ga and Si) and magnetic properties of their carburized powders

    International Nuclear Information System (INIS)

    Kubis, M.; Rave, W.; Cao, L.; Gebel, B.; Mueller, K.-H.; Schultz, L.

    1998-01-01

    The application of the hydrogenation-disproportionation-desorption-recombination (HDDR) process in Sm 2 Fe 16 M (M=Al,Ga and Si) was investigated. The hydrogen absorption behaviour was studied by temperature-pressure analysis (TPA). In the temperature range between 500 and 800 C, Sm 2 Fe 16 M samples with M=Ga and Si show a weaker hydrogen absorption than Sm 2 Fe 16 Al. This was confirmed by X-ray diffraction which showed a complete disproportionation of Sm 2 Fe 16 Al into SmH z (1.9 2 Fe 16 Ga and Sm 2 Fe 16 Si exhibit a fraction of undecomposed material with the Th 2 Zn 17 -type structure after the disproportionation procedure. These results point to a stabilization of Sm 2 Fe 16 M against disproportionation by hydrogen for M=Ga and Si. The magnetization processes of carburized HDDR powders were studied by VSM measurements and Kerr microscopy. The demagnetization curve of our HDDR processed Sm 2 Fe 16 AlC y is well shaped, whereas those of Sm 2 Fe 16 GaC y and Sm 2 Fe 16 SiC y show a large decrease of the polarization at low fields. The favourable behaviour of Sm 2 Fe 16 AlC y is due to a homogeneous submicron grain structure. In Sm 2 Fe 16 GaC y and Sm 2 Fe 16 SiC y samples, an additional, magnetically soft phase with larger domains was observed which causes the low coercivity. As a consequence, HDDR was only favourable for the preparation of Sm 2 Fe 16 MC y hard magnets with M=Al but not for M=Ga and Si. Optimization of the HDDR process in Sm 2 Fe 16 Al and subsequent nitrogenation or carburization led to coercivities of μ 0j H c =2.9 and 2.5 T, respectively. (orig.)

  17. Evaluation of an anti-p185{sup HER2} (scFv-C{sub H}2-C{sub H}3){sub 2} fragment following radioiodination using two different residualizing labels: SGMIB and IB-Mal-D-GEEEK

    Energy Technology Data Exchange (ETDEWEB)

    Vaidyanathan, Ganesan [Duke University Medical Center, Durham, NC 27710 (United States)], E-mail: ganesan.v@duke.edu; Jestin, Emmanuelle [Duke University Medical Center, Durham, NC 27710 (United States); Olafsen, Tove; Wu, Anna M. [Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095 (United States); Zalutsky, Michael R. [Duke University Medical Center, Durham, NC 27710 (United States)

    2009-08-15

    Introduction: A 105-kDa double mutant single-chain Fv-Fc fragment (scFv-Fc DM) derived from the anti-p185{sup HER2} hu4D5v8 antibody (trastuzumab; Herceptin) has been described recently. The goal of this study was to investigate whether improved tumor targeting could be achieved with this fragment through the use of residualizing radioiodination methods. Methods: The scFv-Fc DM fragment was radioiodinated using N-succinimidyl 4-guanidinomethyl 3-[{sup 131}I]iodobenzoate ([{sup 131}I]SGMIB) and N{sup {epsilon}}-(3-[{sup 131}I]iodobenzoyl)-Lys{sup 5}-N{sup {alpha}}- maleimido-Gly{sup 1}-GEEEK ([{sup 131}I]IB-Mal-D-GEEEK), two residualizing radioiodination agents that have been used successfully with intact antibodies. Paired-label internalization assays of the labeled fragments were performed in vitro using MCF7 human breast cancer cells transfected to express HER2 (MCF7-HER2); comparisons were made to scFv-Fc DM directly radioiodinated using Iodogen. The tissue distribution of the scFv-Fc DM labeled with [{sup 125}I]IB-Mal-D-GEEEK and [{sup 131}I]SGMIB was compared in athymic mice bearing MCF7-HER2 xenografts. Results: The scFv-Fc DM fragment was labeled with [{sup 131}I]SGMIB and [{sup 131}I]IB-Mal-D-GEEEK in conjugation yields of 53% and 25%, respectively, with preservation of immunoreactivity for HER2. Internalization assays indicated that labeling via SGMIB resulted in a 1.6- to 3.5-fold higher (P<.05) retention of radioactivity, compared to that from the directly labeled fragment, in HER2-expressing cells during a 24-h observation period. Likewise, the amount of radioactivity retained in cells from the IB-Mal-D-GEEEK-labeled fragment was 1.4- to 3.3-fold higher (P<.05). Tumor uptake of radioiodine activity in athymic mice bearing MCF7-HER2 xenografts in vivo was significantly higher for the [{sup 125}I]IB-Mal-D-GEEEK-labeled scFv-Fc DM fragment compared with that of the [{sup 131}I]SGMIB-labeled fragment, particularly at later time points. The uptake of {sup

  18. Malaria diagnosis and treatment under the strategy of the integrated management of childhood illness (IMCI): relevance of laboratory support from the rapid immunochromatographic tests of ICT Malaria P.f/P.v and OptiMal.

    Science.gov (United States)

    Tarimo, D S; Minjas, J N; Bygbjerg, I C

    2001-07-01

    The algorithm developed for the integrated management of childhood illness (IMCI) provides guidelines for the treatment of paediatric malaria. In areas where malaria is endemic, for example, the IMCI strategy may indicate that children who present with fever, a recent history of fever and/or pallor should receive antimalarial chemotherapy. In many holo-endemic areas, it is unclear whether laboratory tests to confirm that such signs are the result of malaria would be very relevant or useful. Children from a holo-endemic region of Tanzania were therefore checked for malarial parasites by microscopy and by using two rapid immunochromatographic tests (RIT) for the diagnosis of malaria (ICT Malaria P.f/P.v and OptiMal. At the time they were tested, each of these children had been targeted for antimalarial treatment (following the IMCI strategy) because of fever and/or pallor. Only 70% of the 395 children classified to receive antimalarial drugs by the IMCI algorithm had malarial parasitaemias (68.4% had Plasmodium falciparum trophozoites, 1.3% only P. falciparum gametocytes, 0.3% P. ovale and 0.3% P. malariae). As indicators of P. falciparum trophozoites in the peripheral blood, fever had a sensitivity of 93.0% and a specificity of 15.5% whereas pallor had a sensitivity of 72.2% and a specificity of 50.8%. The RIT both had very high corresponding sensitivities (of 100.0% for the ICT and 94.0% for OptiMal) but the specificity of the ICT (74.0%) was significantly lower than that for OptiMal (100.0%). Fever and pallor were significantly associated with the P. falciparum asexual parasitaemias that equalled or exceeded the threshold intensity (2000/microl) that has the optimum sensitivity and specificity for the definition of a malarial episode. Diagnostic likelihood ratios (DLR) showed that a positive result in the OptiMal test (DLR = infinity) was a better indication of malaria than a positive result in the ICT (DLR = 3.85). In fact, OptiMal had diagnostic reliability (0

  19. Unravelling Local Atomic Order of the Anionic Sublattice in M(Al1-x Gax )4 with M=Sr and Ba by Using NMR Spectroscopy and Quantum Mechanical Modelling.

    Science.gov (United States)

    Pecher, Oliver; Mausolf, Bernhard; Peters, Volker; Lamberts, Kevin; Korthaus, Alexander; Haarmann, Frank

    2016-12-05

    The quasibinary section of the intermetallic phases MAl 4 and MGa 4 with M=Sr and Ba have been characterised by means of X-ray diffraction (XRD) studies and differential thermal analysis. The binary phases show complete miscibility and form solid solutions M(Al 1-x Ga x ) 4 with M=Sr and Ba. These structures crystallise in the BaAl 4 structure type with four- and five-bonded Al and/or Ga atoms (denoted as Al(4b), Al(5b), Ga(4b), and Ga(5b), respectively) that form a polyanionic Al/Ga sublattice. Solid state 27 Al NMR spectroscopic analysis and quantum mechanical (QM) calculations were applied to study the bonding of the Al centres and the influence of Al/Ga substitution, especially in the regimes with low degrees of substitution. M(Al 1-x Ga x ) 4 with M=Sr and Ba and 0.925≤x≤0.975 can be described as a matrix of the binary majority compound in which a low amount of the Ga atoms has been substituted by Al atoms. In good agreement with the QM calculations, 27 Al NMR investigations and single crystal XRD studies prove a preferred occupancy of Al(4b) for these substitution regimes. Furthermore, two different local Al environments were found, namely isolated Al(4b1) atoms and Al(4b2), due to the formation of Al(4b)-Al(4b) pairs besides isolated Al(4b) atoms within the polyanionic sublattice. QM calculations of the electric field gradient (EFG) using superlattice structures under periodic boundary conditions are in good agreement with the NMR spectroscopic results. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. O mal-estar na modernidade e a psicanálise: a psicanálise à prova do social The discontent in modernity and psychoanalysis: social-proof psychoanalysis

    Directory of Open Access Journals (Sweden)

    Joel Birman

    2005-01-01

    Full Text Available O artigo tem a intenção de indicar a presença de dois discursos teóricos opostos em Freud, no que concerne às relações entre sujeito e modernidade. Pretende-se demonstrar que na sua segunda versão, desenvolvida em Mal-estar na civilização, o discurso psicanalítico realizou uma crítica sistemática de sua versão inicial, esboçada em "Moral sexual 'civilizada' e a doença nervosa dos tempos modernos". Pela construção dos conceitos de desamparo e de mal-estar, o discurso freudiano colocou então a psicanálise à prova do social. Além disso, indica que aquela pôde construir uma leitura sobre a modernidade, ao lado das que foram realizadas por Weber e Heidegger. Finalmente, esse percurso tem ainda a finalidade de pensar a crise da psicanálise na atualidade, nas novas condições do mal-estar na modernidade.The article aims at showing the presence of two opposing theoretical discourses in Freud, in what concerns the relationship between the subject and modemity. It intends to demonstrate that in its second version, developed in Malaise dansia civilisation, the analytical discourse achieved a systematic critical review of its initial version outlined in "La morale sexuelle 'civilisée' et la maladie nerveuse des temps modemes". Through constructing the concepts of discontent and distress, the Freudian discourse thus made psychoanalysis social-proof. ln addition, it indicates that psychoanalysis was able to build a reading of modemity other than those made by Weber and Heidegger. Finally, this joumey also aims at thinking over the present crisis of psychoanalysis within the new conditions of discontent in modemity.

  1. “El florecimiento del terrorismo islámico en el Sahel, un reto para la seguridad de Europa Occidental. Estudio de caso: Malí y España (2011- 2013)”

    OpenAIRE

    Rodríguez Uribe, Mónica Alejandra

    2015-01-01

    El objetivo central de este Estudio de Caso, consiste en investigar en qué sentido la proximidad geográfica y el hecho de que la región del Sahel constituya una zona de tránsito, influyen a que el crecimiento del terrorismo islámico en Malí comprenda una amenaza tanto para la seguridad nacional, como para la estabilidad de España. Se avanzará posteriormente con la descripción de herramientas específicas, tanto judiciales como de cooperación que el gobierno español ha buscado apoyar a nivel ...

  2. Luminescent phosphors, based on rare earth substituted oxyfluorides in the A(1)3-x A(2)xMO4F family with A(1)/A(2)=Sr, Ca, Ba and M=Al, Ga

    International Nuclear Information System (INIS)

    Park, Sangmoon; Vogt, Thomas

    2009-01-01

    A new family of UV-activated phosphors made by substituting rare-earth activators such as trivalent Eu, Tb, Tm and Er into A(1) 3-x A(2) x MO 4 F host lattices (A(1)/A(2)=Sr, Ca, Ba; M=Al, Ga) are introduced and their activation and emission spectra as well as their CIE values reported. The Tm-substituted system can be activated using light with a wavelength of 360 nm. Relative intensities of a family of Tb-substituted green phosphors activated at 254 nm and with emissions centered near 548 nm are discussed.

  3. Luminescent phosphors, based on rare earth substituted oxyfluorides in the A(1){sub 3-x} A(2){sub x}MO{sub 4}F family with A(1)/A(2)=Sr, Ca, Ba and M=Al, Ga

    Energy Technology Data Exchange (ETDEWEB)

    Park, Sangmoon, E-mail: spark@silla.ac.k [Department of Engineering in Energy and Applied Chemistry, Silla University, Busan 617-736 (Korea, Republic of); Vogt, Thomas [NanoCenter and Department of Chemistry and Biochemistry, University of South Carolina, Columbia 29208, SC (United States)

    2009-09-15

    A new family of UV-activated phosphors made by substituting rare-earth activators such as trivalent Eu, Tb, Tm and Er into A(1){sub 3-x}A(2){sub x}MO{sub 4}F host lattices (A(1)/A(2)=Sr, Ca, Ba; M=Al, Ga) are introduced and their activation and emission spectra as well as their CIE values reported. The Tm-substituted system can be activated using light with a wavelength of 360 nm. Relative intensities of a family of Tb-substituted green phosphors activated at 254 nm and with emissions centered near 548 nm are discussed.

  4. Estudio descriptivo de mal oclusiones y opciones de tratamiento en estudiantes de segundo y tercer semestre de la Universidad de las Américas del Distrito Metropolitano de Quito, período Octubre 2013 – Enero 2014

    OpenAIRE

    Santacruz Escobar, Paul Santiago

    2014-01-01

    Las mal oclusiones dentales son patologías frecuentes en la cavidad bucal a nivel mundial, debido a que esta enfermedad es multifactorial además de verse afectada por otros procesos patológicos, surge la importancia decisiva de tomar medidas de salud pública para contrarrestar las secuelas de dicha enfermedad, así como su pronta prevención. El presente estudio es de carácter descriptivo, transversal, en el cual fueron examinados 268 estudiantes entre diecisiete y veinte y cinco años de edad, ...

  5. La miseria de la literatura: el mal en las representaciones de los escritores de La literatura nazi en América, Estrella distante y la no ficción de Roberto Bolaño

    OpenAIRE

    Villacreses Benavides, Norman Xavier

    2016-01-01

    La obra y la figura como escritor de Roberto Bolaño es uno de los espacios de investigación de los estudios literarios más importantes en la actualidad. Esto se debe tanto a la repercusión de su ficción dentro de la narrativa hispanoamericana contemporánea como a sus posiciones frente al ejercicio de la literatura. Esta investigación se ha propuesto hallar de qué forma se generan las representaciones del mal dentro del universo literario de Bolaño y cuál es su funcionamiento, tomando como ele...

  6. Un cinéma palestinien « en mal d’archive » The “Archive Fever” of Palestinian Cinema

    Directory of Open Access Journals (Sweden)

    Laure Fourest

    2012-05-01

    Full Text Available À partir de l’analyse de trois films palestiniens réalisés dans les années 2000, cet article propose d’interroger l’insertion d’images d’archives par les cinéastes dans leur montage : quelles stratégies mettent-ils en œuvre et à quelles fins ? Qu’apportent des images d’archives en plus des témoignages filmés ? Comment le recours à ces images permet-il de participer au débat historiographique qui sous-tend et détermine en partie le conflit israélo-palestinien ? Dans le contexte palestinien où il n’existe pas d’institution archivistique officielle, les archives sont porteuses d’enjeux particulièrement saillants, donnant lieu à un véritable « mal d’archive ». Celui-ci fait naître une multiplicité de stratégies cinématographiques visant à questionner cette zone d’inconfort, où le maniement des qualités émotionnelles et sensorielles de l’archive peut être un moyen de faire preuve.Through the analysis of three Palestinian films created in the 2000-2010 period, this article considers filmmakers’ insertion of archival images in their montages: what strategies do they employ and for what purpose? What do archival images add to filmed testimony? How does the use of these images enable participation in the historiographical debate underlying and partly determining the Israel-Palestine conflict? In the Palestinian context, where no official archive institution exists, archives entail particularly salient issues, making their lack truly sore. This generates a multiplicity of cinematographic strategies aiming to challenge this discomfort zone, where the manipulation of the emotional and sensorial qualities of archives can be a means of proving something.

  7. Hydrogenation-disproportionation-desorption-recombination in Sm{sub 2}Fe{sub 16}M (M=Al, Ga and Si) and magnetic properties of their carburized powders

    Energy Technology Data Exchange (ETDEWEB)

    Kubis, M.; Rave, W.; Cao, L.; Gebel, B.; Mueller, K.-H.; Schultz, L. [Institut fuer Festkoerper- und Werkstofforschung Dresden e.V. (Germany)

    1998-11-20

    The application of the hydrogenation-disproportionation-desorption-recombination (HDDR) process in Sm{sub 2}Fe{sub 16}M (M=Al,Ga and Si) was investigated. The hydrogen absorption behaviour was studied by temperature-pressure analysis (TPA). In the temperature range between 500 and 800 C, Sm{sub 2}Fe{sub 16}M samples with M=Ga and Si show a weaker hydrogen absorption than Sm{sub 2}Fe{sub 16}Al. This was confirmed by X-ray diffraction which showed a complete disproportionation of Sm{sub 2}Fe{sub 16}Al into SmH{sub z} (1.9M=Al but not for M=Ga and Si. Optimization of the HDDR process in Sm{sub 2}Fe{sub 16}Al and subsequent nitrogenation or carburization led to coercivities of {mu}{sub 0j}H{sub c}=2.9 and 2.5 T, respectively. (orig.) 11 refs.

  8. Faktoring – jedna z hlavních forem financování malých a středních podniků

    Directory of Open Access Journals (Sweden)

    Müllerová Libuše

    2009-12-01

    Full Text Available Faktoring představuje službu, kterou poskytují specializované faktoringové společnosti svým klientům v souvislosti s postoupením nebo se správou pohledávek. Ve své podstatě se jedná o určitý způsob úvěrování, využívaný zejména malými a středními podniky. V praxi existuje několik forem faktoringu v závislosti na tom, do jaké míry přechází na faktora vlastnictví pohledávek a rizika jejich nesplacení. Podle toho se pak faktoringové transakce promítají do účetnictví faktora i klienta. Vzhledem k tomu, že tato služba ani její formy není upravená žádným právním předpisem, postupují faktoringové společnosti často tak, že podmínky ve smlouvách – z důvodu daňových – často zakrývají svojí formou skutečný stav. Uvedený příspěvek základní formy faktoringu vymezuje, popisuje jejich správné účtování včetně daňových dopadů. Factoring is a service, which is offered by specialized factoring agencies to their clients in case of transfer (sale or governance of receivables. In fact, it represents a specific mode of crediting which is mostly preferred by small and medium enterprises. In practices of factoring several forms are differentiated depending on scale of property and risk transfer to the factor. According to these circumstances the factoring transactions are recognized by the factor and the client. The factoring services are not so far regulated by any legal provision. For this reason factoring agencies are proceeding in such a way, that contract conditions – because of tax considerations – hide by their form the substance. The paper describes the factoring forms and interprets their correct recognition on accounting, including tax consequences.

  9. FACTORES ASOCIADOS A MAL ESTADO DE SALUD PERCIBIDO O A MALA CALIDAD DE VIDA EN PERSONAS MAYORES DE 65 AÑOS

    Directory of Open Access Journals (Sweden)

    Mercedes Azpiazu Garrido

    2002-01-01

    Full Text Available Fundamento: Hoy en d a, en los pa ses desarrollados, llegar a una edad avanzada ha dejado de ser algo excepcional, sin embargo muchas personas no logran envejecer con una buena calidad de vida. El presente trabajo tiene como objetivos, contribuir a un mejor conocimiento de los principales factores que influyen en la calidad de vida y la percepci n de la salud de los mayores de 65 a os, as como determinar qu ventajas y desventajas presenta cada uno de los tres instrumentos de medida de la salud y la calidad de vida frente a los otros dos instrumentos utilizados. M todos: A partir de 911 encuestas a personas mayores de 65 a os no institucionalizadas, realizadas a domicilio, se hizo un an lisis multivariante mediante regresi n log stica, poniendo en relaci n los resultados obtenidos en el Perfil de Salud de Nottingham (PSN, el Euroqol y el EAS con las caracter siticas sociodemogr ficas, el nivel de recursos econ micos, el grado de apoyo sociofamiliar, el estado de salud f sica y mental y la capacidad funcional. Resultados: Los principales factores que se asocian con la percepci n de un mal estado de salud y mala calidad de vida en el Euroqol y el PSN son los trastornos de ansiedad (Odd Ratios entre 1,8 (IC:1,2-2,8 para movilidad y 7,9 (IC:4,5-13,9 para Perfil 11111, trastornos depresivos (OR:1,8 (IC:1,3-2,6 para dolor/malestar ?3,3 (IC:2,1-5,1 para aislamiento social, falta de ejercicio (OR:1,4 (IC:1-2,1 para ansiedad/depresi n ?3,9 (IC:2,5-6,2 para actividades cotidianas, dependencia para las actividades b sicas de la vida diaria (OR:0,5 (IC:0,3-0,9 para reacci n emocional ?4,8 (IC:3-7,6 para actividades cotidianas y dependencia para las actividades instrumentales de la vida diaria (OR:1,5 (IC:1,1-2,1 para Escala Visual Anal gicac < 70 ? 7,1 (IC:2,9-17,2 para cuidado personal. Conclusiones: La salud mental y la capacidad funcional son los factores que m s influyen en la percepci n del estado de salud y la calidad de vida de las personas mayores

  10. Retardo no crescimento intrauterino, baixo peso ao nascer e prematuridade em recém-nascidos de grávidas com malária, na Colômbia Intrauterine growth retardation, low birth weight and prematurity in neonates of pregnant women with malaria in Colombia

    OpenAIRE

    Alberto Tobón-Castaño; Martha Arismendi Solano; Luis Gonzalo Álvarez Sánchez; Silvia Blair Trujillo

    2011-01-01

    INTRODUÇÃO: É frequente a associação da malária com complicações como prematuridade, retardo no crescimento intrauterino, baixo peso ao nascer e mortalidade infantil, efeitos pouco estudados em áreas hipoendêmicas para malaria. O objetivo deste estudo foi analisar a relação da malária gestacional com estes efeitos em recém-nascidosnuma região endêmica para malária na Colômbia, entre 1993 e 2007. MÉTODOS: Foram estudadas as características em 1.716 recém-nascidos num estudo de coorte. Fez-se s...

  11. Malária durante a gravidez: efeito sobre o curso da gestação na região amazônica Impact of malaria during pregnancy in the Amazon region

    Directory of Open Access Journals (Sweden)

    Eda Cristina da Silva Chagas

    2009-09-01

    Full Text Available OBJETIVO: Estimar o efeito da malária sobre o curso da gestação em mulheres na região amazônica e investigar possíveis fatores de risco nessa população. MÉTODOS: Este estudo transversal é parte de um projeto maior para estudar malária e gravidez na região amazônica. Foram incluídas gestantes com malária atendidas na Fundação de Medicina Tropical do Amazonas que responderam a entrevistas estruturadas. Dados socio-econômicos, comportamentais e clínicos foram levantados na primeira consulta relacionada a cada novo episódio de malária na gestante. Todas as gestantes foram acompanhadas ao longo de sua gestação. Foram considerados os seguintes fatores de risco para alterações no curso da gestação: idade materna menor do que 20 anos, primeira gestação, primeira infecção malárica e espécie de plasmódio infectante. RESULTADOS: Foram avaliados 535 episódios de malária em 417 gestantes, sendo 20,56% causados pelo P. falciparum, 78,69% pelo P. vivax e 0,75% pela associação dos dois parasitas. Alteração no curso da gestação foi um evento muito frequente (26,2%. Ameaça de aborto ocorreu em 49 casos (25,5%, aborto em dois (1,0%, ameaça de parto prematuro em 74 (25,1% e parto prematuro em três (1,0%. Ser primigesta e adolescente apresentou associação estatisticamente significativa com ameaça de parto prematuro e abortamento. CONCLUSÃO: A alteração no curso da gestação foi um evento muito frequente durante o episódio agudo de malária, embora a interrupção da gestação tenha tido baixa ocorrência em nossa casuística. Os resultados não evidenciaram um fator de risco de destaque, sugerindo que qualquer gestante pode apresentar ameaça de interrupção ou interrupção da gestação na vigência de episódio agudo de malária.OBJECTIVE: To estimate the impact of malaria on the course of pregnancy in women from the Amazon region and to investigate possible risk factors in this population. METHODS: This

  12. Structure, microstructure and determination of optical constants from transmittance data of co-doped Zn0.90Co0.05M0.05O (M=Al, Cu, Cd, Na) films

    International Nuclear Information System (INIS)

    2 A Laboratoire des Structures, Propriétés et Interactions Inter Atomiques, Université Abbes Laghrour, Khenchela 40000 (Algeria))" data-affiliation=" (LASPI2 A Laboratoire des Structures, Propriétés et Interactions Inter Atomiques, Université Abbes Laghrour, Khenchela 40000 (Algeria))" >Roguai, S.; 2 A Laboratoire des Structures, Propriétés et Interactions Inter Atomiques, Université Abbes Laghrour, Khenchela 40000 (Algeria))" data-affiliation=" (LASPI2 A Laboratoire des Structures, Propriétés et Interactions Inter Atomiques, Université Abbes Laghrour, Khenchela 40000 (Algeria))" >Djelloul, A.; Nouveau, Corinne; Souier, T.; Dakhel, A.A.; Bououdina, M.

    2014-01-01

    Highlights: • A series of Zn 0.90 Co 0.05 M 0.05 O (M=Al, Cu, Cd, Na) films has been prepared. • Thin films of these prepared samples have been deposited using USP technique. • Absorption of electronic transition has been used to fit the transmittance data. • Optical and dispersion parameters have been determined. - Abstract: ZnO, Zn 0.95 Co 0.05 O and Zn 0.90 Co 0.05 M 0.05 O (M=Al, Cd, Na, Cu) single phase films have been successfully synthesized by ultrasonic spray pyrolysis technique. Structural analysis by X-ray diffraction show that all the films have hexagonal wurtzite structure with an average crystallite size in the range of 19–25 nm. SEM analysis revealed that Cd and Na preserve the shape of nanopetals observed with ZnO or Co-ZnO films, while the doping with Al or Cu promote the formation of dense films constituted of nanorods. By the application of Levenberg–Marquardt least square method, the experimental transmittance data were fitted perfectly with the transmittance data calculated via a combination of Wemple–DiDomenico model, absorption coefficient of an electronic transition and Tauc–Urbach model. The concentration of absorbing centres N Co and oscillator strength f of d–d transition of Co 2+ ions are calculated from Smakula’s formula

  13. Luminescent properties of MAl(SO4)2 Br:Eu(3+) (M = Sr or Mg) red phosphors for near-UV light-emitting diodes.

    Science.gov (United States)

    Deshmukh, Priti B; Puppalwar, S P; Dhoble, N S; Dhoble, S J

    2015-02-01

    Eu(3+) -activated MAl(SO4 )2 Br phosphors (where M = Mg or Sr) are successfully prepared using a wet chemical reaction technique. The samples are characterized by X-ray diffraction (XRD) and photoluminescence (PL) spectroscopies. The XRD pattern revealed that both the samples are microcrystalline in nature. PL of Eu(3+) -doped SrAl(SO4 )2 Br and MgAl(SO4 )2 Br phosphors exhibited characteristic red emission coming from the (5) D0  → (7) F2 (616 nm) electron transition, when excited by 396 nm wavelength of light. The maximum intensity of luminescence was observed at a concentration of 1 mol% Eu(3+) . The intensity of the electric dipole transition at 616 nm is greater than that of the magnetic dipole transition at 594 nm. The results showed that MAl(SO4 )2 Br:Eu(3+) , (M = Mg, Sr) phosphors have potential application in near-UV light-emitting diodes as efficient red-emitting phosphor. Copyright © 2014 John Wiley & Sons, Ltd.

  14. Prostorové rozhraní informačního systému malé obce řešené v Open Source Software

    Directory of Open Access Journals (Sweden)

    Karel Jedlička

    2006-12-01

    Full Text Available Příspěvek si klade za cíl představit možnosti open source software pro implementaci prostorového rozhraní informačního systému malé obce.Zabývá se návrhem projektu po jednotlivých částech: identifikace požadavků zastupitelského úřadu (uživatele systému, popis obecné architektury systému a volba vhodných (nekomerčních technologií pro jeho implementaci. Součástí projektu je i popis vyvinuté technologie pro import nejdůležitějších datových vrstev (informací o vlastnictví do systému.Článek je doplněn výčtem využitelných datových zdrojů pro informační systém malé obce v České republice.

  15. Fertilizantes e espaçamento entre plantas na produtividade da couve-da-Malásia Fertilizers and spacing between plants in the yield of Malaysian cabbage

    Directory of Open Access Journals (Sweden)

    Wanessa Resende Ferreira

    2002-12-01

    Full Text Available As brássicas têm sido objeto constante de pesquisa devido à sua importância na alimentação humana, seja pela quantidade consumida, pelo alto valor nutricional ou por sua elevada produtividade. Brassica chinensis var. parachinensis foi introduzida no Brasil, Uberlândia, em 1992, destacando-se em relação a outras brássicas por seu alto teor de vitaminas A e C, cálcio e ferro, estando pronta para consumo em aproximadamente 30 dias. A produtividade biológica e agronômica dessa variedade foi analisada utilizando-se três tipos de fertilizantes e três espaçamentos entre plantas, visando subsidiar sua produção em escala comercial. A área foliar, massa da matéria seca e taxa de crescimento absoluto foram significativamente maiores com adubação mineral em relação à adubação orgânica. Os maiores valores referentes à taxa de crescimento relativo e taxa assimilatória líquida foram registrados em plantas mantidas nos maiores espaçamentos (30x20 e 30x30 cm. A maior produtividade agronômica foi alcançada no menor espaçamento (30x10 cm, com adubação mineral, sendo registrados 21,5 t ha-1, valor muito próximo ao registrado na Malásia e China onde essa hortaliça é cultivada em larga escala.Brassica crops have been widely studied due to their importance as food for human consumption, especially in relation to their nutritional value. Both yield and consumption are high. Brassica chinensis var. parachinensis was introduced in Brazil, in Uberlândia, in 1992, surpassing other Brassica due to its high content of vitamins A and C, calcium and iron, and being ready for consumption in about 30 days. The biological and agronomic yield of this variety was analyzed under three kinds of fertilizers and three spacings between plants with a view to its production on a commercial scale. The leaf area, dry matter mass, and absolute growth rate were higher with mineral than organic fertilizer. High values for relative growth rate and net

  16. Ejercicio y la detección del mal agudo de montaña grave Exercise and the detection of severe acute mountain sickness

    Directory of Open Access Journals (Sweden)

    Adrián Garófoli

    2010-02-01

    Full Text Available El mal agudo de montaña (MAM es un conjunto de síntomas inespecíficos padecidos por sujetos que ascienden rápidamente desde baja a alta altura sin adecuada aclimatación. Usualmente es autolimitado, pero las formas graves (edema pulmonar y cerebral pueden causar la muerte. La hipoxemia exagerada en reposo está relacionada con el desarrollo de MAM pero su valor predictivo es limitado. Dado que el ejercicio en altura se acompaña de mayor hipoxemia y síntomas, postulamos el valor predictivo de un simple test de ejercicio para pronosticar MAM grave. Se estudió el valor predictivo de la saturación de oxígeno en reposo y ejercicio submáximo a 2.700 m y 4 300 m en 63 sujetos que ascendían al cerro Aconcagua (6 962 m. Se consideró desaturación de oxígeno con ejercicio a una disminución = 5% respecto al reposo. Se utilizó la escala de Lake-Louise para establecer la presencia de MAM grave. Seis sujetos presentaron MAM grave (9.5% y requirieron evacuación. La saturación de oxígeno en reposo a 2.700 m no fue significativa para clasificar sujetos que luego desarrollaron MAM grave. Por el contrario, la asociación de desaturación durante el ejercicio a 2.700 m más la saturación inapropiada en reposo a 4.300 m fue significativa para clasificar a los sujetos que desarrollaron MAM grave con un valor predictivo positivo de 80% y un valor predictivo negativo del 97%. Nuestros resultados son relevantes para el montañismo y sugieren la adición de un simple test de ejercicio en la predicción del MAM grave.Acute mountain sickness (AMS is a group of non-specific symptoms, seen in subjects that ascend from low to high altitude too quickly, without allowing sufficient time to acclimatize. Usually it is self-limiting, but the severe forms (pulmonary and cerebral edema can be fatal. Exaggerated hypoxemia at rest is related to later development of AMS but its predictive value is limited. Since exercise at altitude induces greater hypoxemia and

  17. Factores asociados a mal estado de salud percibido o a mala calidad de vida en personas mayores de 65 años

    Directory of Open Access Journals (Sweden)

    Azpiazu Garrido Mercedes

    2002-01-01

    Full Text Available Fundamento: Hoy en día, en los países desarrollados, llegar a una edad avanzada ha dejado de ser algo excepcional, sin embargo muchas personas no logran envejecer con una buena calidad de vida. El presente trabajo tiene como objetivos, contribuir a un mejor conocimiento de los principales factores que influyen en la calidad de vida y la percepción de la salud de los mayores de 65 años, así como determinar qué ventajas y desventajas presenta cada uno de los tres instrumentos de medida de la salud y la calidad de vida frente a los otros dos instrumentos utilizados. Métodos: A partir de 911 encuestas a personas mayores de 65 años no institucionalizadas, realizadas a domicilio, se hizo un análisis multivariante mediante regresión logística, poniendo en relación los resultados obtenidos en el Perfil de Salud de Nottingham (PSN, el Euroqol y el EAS con las caracterísiticas sociodemográficas, el nivel de recursos económicos, el grado de apoyo sociofamiliar, el estado de salud física y mental y la capacidad funcional. Resultados: Los principales factores que se asocian con la percepción de un mal estado de salud y mala calidad de vida en el Euroqol y el PSN son los trastornos de ansiedad (Odd Ratios entre 1,8(IC:1,2-2,8 para movilidad y 7,9(IC:4,5-13,9 para Perfil ≠11111, trastornos depresivos (OR:1,8(IC:1,3-2,6 para dolor/malestar- 3,3(IC:2,1-5,1 para aislamiento social, falta de ejercicio (OR:1,4 (IC:1-2,1 para ansiedad/depresión -3,9(IC:2,5-6,2 para actividades cotidianas, dependencia para las actividades básicas de la vida diaria (OR:0,5(IC:0,3-0,9 para reacción emocional - 4,8(IC:3-7,6 para actividades cotidianas y dependencia para las actividades instrumentales de la vida diaria (OR:1,5(IC:1,1-2,1 para Escala Visual Analógicac<70 - 7,1(IC:2,9-17,2 para cuidado personal. Conclusiones: La salud mental y la capacidad funcional son los factores que más influyen en la percepción del estado de salud y la calidad de vida de las

  18. Necropsia e mortalidade por causa mal definida no Estado de São Paulo, Brasil Autopsy and ill-defined cause of death in the state of São Paulo, Brazil

    Directory of Open Access Journals (Sweden)

    Mauro Abrahão Rozman

    2006-11-01

    Full Text Available OBJETIVO: Investigar a proporção de mortes por causa mal definida no Estado de São Paulo entre 1980 e 2002, considerando a influência da realização de necropsia nessa proporção. MÉTODO: O número de óbitos foi obtido do Ministério da Saúde. Dividiu-se o Estado de São Paulo em três áreas: 1 municípios com serviço de verificação de óbitos (SVO, que pode realizar necropsias; 2 municípios sem SVO; e 3 Baixada Santista, região onde houve um aumento marcante na proporção de mortes por causa mal definida entre 1980 e 1995. O impacto das necropsias na proporção de óbitos por causa mal definida foi medido com base na classificação da causa de óbito pelo primeiro médico avaliador (aquele que encaminhou o caso para o SVO para necropsia ou que preencheu a declaração de óbito sem encaminhar o caso. Os óbitos por causas externas foram excluídos por ter necropsia obrigatória. Foram avaliadas as proporções 1 de casos classificados como de causa mal definida pelo primeiro avaliador; 2 de necropsias no total de óbitos excluindo causas externas; e 3 de óbitos com causa esclarecida por necropsia entre os classificados como de causa mal definida pelo primeiro avaliador. RESULTADOS: A proporção de óbitos classificados como de causa mal definida pelo primeiro avaliador aumentou entre 1980 e 2002 em todas as áreas: nos municípios com SVO, nos municípios sem SVO e na Baixada Santista. Para o Estado de São Paulo como um todo, o aumento foi de quase 30% no período de 1980 a 2002. Para o período de 1998 a 2002, a proporção média de necropsias no total de óbitos excluindo causas externas foi de 21,2, 6,4 e 2,6%, respectivamente, nas áreas com e sem SVO e na Baixada Santista. Entre 1998 e 2002, a proporção de óbitos com causa mal definida esclarecidos pela necropsia foi de 92,9 nas áreas com SVO, 32,5 nas áreas sem SVO e 10,7% na Baixada Santista. CONCLUSÕES: A realização de necropsias explica a diferença na

  19. Genesis of the Assif El Mal Zn-Pb (Cu, Ag) vein deposit. An extension-related Mesozoic vein system in the High Atlas of Morocco. Structural, mineralogical, and geochemical evidence

    Science.gov (United States)

    Bouabdellah, M.; Beaudoin, G.; Leach, D.L.; Grandia, F.; Cardellach, E.

    2009-01-01

    The Assif El Mal Zn-Pb (Cu-Ag) vein system, located in the northern flank of the High Atlas of Marrakech (Morocco), is hosted in a Cambro-Ordovician volcaniclastic and metasedimentary sequence composed of graywacke, siltstone, pelite, and shale interlayered with minor tuff and mudstone. Intrusion of synorogenic to postorogenic Late Hercynian peraluminous granitoids has contact metamorphosed the host rocks giving rise to a metamorphic assemblage of quartz, plagioclase, biotite, muscovite, chlorite, amphibole, chloritoid, and garnet. The Assif El Mal Zn-Pb (Cu-Ag) mineralization forms subvertical veins with ribbon, fault breccia, cockade, comb, and crack and seal textures. Two-phase liquid-vapor fluid inclusions that were trapped during several stages occur in quartz and sphalerite. Primary inclusion fluids exhibit Th mean values ranging from 104??C to 198??C. Final ice-melting temperatures range from -8.1??C to -12.8??C, corresponding to salinities of ???15 wt.% NaCl equiv. Halogen data suggest that the salinity of the ore fluids was largely due to evaporation of seawater. Late secondary fluid inclusions have either Ca-rich, saline (26 wt.% NaCl equiv.), or very dilute (3.5 wt.% NaCl equiv.) compositions and homogenization temperatures ranging from 75??C to 150??C. The ??18O and ??D fluid values suggest an isotopically heterogeneous fluid source involving mixing between connate seawater and black-shale-derived organic waters. Low ??13CVPDB values ranging from -7.5??? to -7.7??? indicate a homogeneous carbon source, possibly organic matter disseminated in black shale hosting the Zn-Pb (Cu-Ag) veins. The calculated ??34SH2S values for reduced sulfur (22.5??? to 24.3???) are most likely from reduction of SO42- in trapped seawater sulfate or evaporite in the host rocks. Reduction of sulfate probably occurred through thermochemical sulfate reduction in which organic matter was oxidized to produce CO2 which ultimately led to precipitation of saddle dolomite with

  20. Malária em grávidas de uma maternidade pública de Rio Branco (Acre, Brasil Malaria in pregnant women of a public maternity of Rio Branco (Acre State, Brazil

    Directory of Open Access Journals (Sweden)

    Regina Jarude

    2003-04-01

    Full Text Available OBJETIVO: descrever a freqüência dos achados clínico-laboratoriais em grávidas portadoras de malária. MÉTODOS: foi realizado estudo descritivo, série de casos, de 445 grávidas da Maternidade e Clínica de Mulheres Bárbara Heliodora (Rio Branco, Acre, do período de janeiro de 1996 a dezembro de 2001, com diagnóstico parasitológico de malária. Foram revistos os prontuários do período e selecionados os casos portadores de malária. RESULTADOS: no total de pacientes (n=33.420 internadas no período, estavam incluídas 445 (1,4% grávidas. Entre essas, a freqüência da infecção por Plasmodium vivax foi de 52,8% (n=235, por P. falciparum, de 43,8% (n=195, e 3,4% (n=15 por ambos os plasmódios. As alterações clínico-laboratoriais mais freqüentes (pPURPOSE: to describe the frequency of clinical and laboratorial findings in pregnant women with malaria. METHODS: a descriptive study was performed including 445 pregnant women with a positive diagnosis of malaria of the Maternity and women's Clinic Bárbara Heliodora (Rio Branco, Acre State, from January 1996 to December 2001. These cases were reviewed and the pregant women with malaria were selected. RESULTS: a total of 33,420 patients were hospitalized in that period. Of these, 445 pregnant women (1.4% were included. Among these, the frequency of the infection with Plasmodium vivax was 52.8% (n=235, with P. falciparum, 43.8% (n=195, and 3.4% (n=15 with both plasmodia. The most frequent clinical and laboratorial alterations (p<0.05 were observed in the patients with P. falciparum: pale mucosa, jaundice hemoglobin and hematocrit decrease, hypoglycemia and increase in serum aminotransferase, urea, creatinine and in bilirubin levels. Only one patient (1/445, a pregnant woman infected with P. falciparum died. Abortions, premature birth and low birth weight were detected in 1.3, 1.1 and 1.1% of the cases, respectively. CONCLUSIONS: these findings reflect the repercussion of malaria during

  1. Mercury exposure and malaria prevalence among gold miners in Pará, Brazil Exposição a mercúrio e prevalência de malária entre garimpeiros de ouro do Pará, Brasil

    Directory of Open Access Journals (Sweden)

    Ellen K. Silbergeld

    2002-10-01

    Full Text Available Economic development, including resource extraction, can cause toxic exposures that interact with endemic infectious diseases. Mercury is an immunotoxic metal used in the amalgamation of gold, resulting in both occupational exposures and environmental pollution. A cross-sectional medical survey was conducted in 1997 on 135 garimpeiros in Para, Brazil, because of their risks of both mercury exposure and malaria transmission. Mean levels of blood and urine mercury were well above non-exposed background levels. Twenty-six subjects had malaria parasitemia: Health symptoms consistent with mercury exposure were reported, but neither symptoms nor signs correlated with mercury levels in blood or urine. We did not find a dose response relationship between mercury exposure and likelihood of prevalent malaria infection, but there was a possible reduction in acquisition of immunity that may be associated with conditions in gold mining, including mercury exposure.O desenvolvimento econômico, incluindo extração de recursos naturais, pode causar exposições tóxicas que interagem com doenças infecciosas endêmicas. O mercúrio é um metal imunotóxico usado na amalgamação do ouro, resultando em exposição ocupacional e poluição ambiental. Devido aos riscos da exposição ao mercúrio e transmissão de malária em 135 garimpeiros do Pará, Brasil, uma avaliação médica "cross-sectional" foi coduzida em 1997. Níveis médios de mercúrio no sangue e na urina encontram-se bem acima dos níveis basais daqueles não expostos. Vinte e seis indivíduos apresentaram parasitemia de malária; sintomas relacionados com exposição ao mercúrio foram adquiridos, mas nenhum dos sintomas/sinais está correlacionado com níveis de mercúrio no sangue ou na urina. Não foi encontrada nenhuma relação de dose-resposta entre exposição ao mercúrio e provável infecção de malária prevalente. Entretanto, verificou-se uma possível redução na aquisição de

  2. O desafio da malária: o caso brasileiro e o que se pode esperar dos progressos da era genômica The malaria challenge: the Brazilian case and what can be expected from progress in genomics

    Directory of Open Access Journals (Sweden)

    Luiz Hildebrando Pereira da Silva

    2002-01-01

    Full Text Available A área endêmica de malária no Brasil se estende atualmente à totalidade da região amazônica, com cerca de 500 mil casos anuais, em geral com situações de baixa e média endemicidade mas ainda apresentando focos de alto risco. Fatores demográficos e socioeconômicos são dominantes nos desafios que enfrentam os Serviços de Saúde Pública no controle da malária. No presente artigo são discutidos fatores determinantes da instabilidade da situação endêmica bem como a necessidade de ações permanentes de vigilância e de intervenção dos Serviços de Saúde para que se evitem surtos epidêmicos e alastramento das áreas endêmicas. No artigo, em seguida, apresenta-se uma síntese de progressos recentes nos estudos da era genômica e pós-genômica sobre o parasita, o vetor e o hospedeiro humano que podem favorecer, no futuro, o desenvolvimento e a melhoria dos métodos de controle da malária.Malaria endemic areas in Brazil are restricted to the Amazon Region, with an average of 500 thousand new cases every year. The situation can be defined as unstable hipoendemic with, however, foci of high endemicity. Demographic and socio economic factors are main determinants in the malaria challenge for the Public Health System. In the present paper, biological and social factors responsible for the unstable endemic situation are discussed. The need for a permanent surveillance and intervention of Public Health Services are stressed to avoid the occurrence of local epidemics and spreading of endemic areas. In the paper, are also summarised recent lines of research developed in the post genomic era in the studies of parasite, vector and human molecular genetics that would favour the development, in the future, of new tools and procedures for malaria control

  3. Malária no Estado do Amapá, Brasil, de 1970 a 2003: trajetória e controle Malaria in Amapá State, Brazil, 1970-2003: background and control

    Directory of Open Access Journals (Sweden)

    Rosilene Ferreira Cardoso

    2007-06-01

    Full Text Available O presente estudo tem por objetivo dimensionar a ocorrência de malária no Estado do Amapá, Brasil, no período de 1970 a 2003. Com dados de lâminas positivas, obtidos junto a agências de informações em saúde, foi construída uma série temporal de índice parasitário anual (IPA, por mil habitantes, considerando as informações de população obtidas junto ao Instituto Brasileiro de Geografia e Estatística. No contexto de um intenso incremento populacional, associado ao desenvolvimento regional, os resultados evidenciaram um aumento no período - não linear - dos valores de IPA, que passaram de 15,1‰, em 1970, para 74‰ no ano 2000. No reverso desse movimento, em meio aos esforços de controle da doença, observa-se uma queda desses valores a partir de 2001, que alcança a ordem prevista de 50% em 2002. Acompanhando o movimento de incidência parasitária anual da malária na Amazônia, esses resultados apontaram para o aumento dos valores do IPA no período de 1970 a 2000, observando-se uma redução nos anos subseqüentes, cumprindo com as metas estabelecidas sob o programa vigente de controle da malária no Estado.The present study aims to describe malaria occurrence from 1970 to 2003 in the State of Amapá, Brazil. With positive films obtained from health agencies, temporal series on the annual parasite incidence - API (per 1,000 inhabitants were elaborated, taking into account population data available from the Brazilian Institute of Geography and Statistics. The results showed an increase in API values, although non-linear, related to the rapid population growth associated with regional economic and social development during the period, ranging from 15.1‰ in 1970 to 74.0‰ in 2000. Reversing this trend, a decrease appeared from 2001 onward, reaching a reduction of 50% in 2002. The results showed an increase in API values from 1970 to 2000, consistent with the incidence profile for malaria occurrence in the Amazon. A

  4. Opava (K. Ú. Kateřinky, Malé Hoštice, okres Opava). " Na hoštických lukách". Doba laténská. Sídliště. Záchranný výzkum.

    Czech Academy of Sciences Publication Activity Database

    Juchelka, Jiří

    2009-01-01

    Roč. 50, 1-2 (2009), s. 312 ISSN 1211-7250 Institutional research plan: CEZ:AV0Z80010507 Keywords : Czech Silesia * Malé Hoštice * Latén Cultur e Subject RIV: AC - Archeology, Anthropology, Ethnology

  5. L'evolució del rol dramàtic de la Bella Dorment i Malèfica a les adaptacions cinematogràfiques homònimes de 1959 i 2014

    OpenAIRE

    Escobar Pérez, Marina

    2015-01-01

    Aquest treball de recerca i investigació és el resultat d'un anàlisi qualitatiu i de gènere realitzat d'acord amb la teoria audiovisual narrativa i la teoria fílmica feminista sobre la representació cinematogràfica dels personatges de la Bella Dorment i Malèfica a les pel•lícules homònimes dels anys 1959 i 2014 amb l'objectiu de determinar l'evolució del seu rol dramàtic. Este trabajo de investigación es el resultado de un análisis cualitativo y de género realizado en base a la teoría audi...

  6. Associations between chewing lice (Insecta, Phthiraptera and albatrosses and petrels (Aves, Procellariiformes collected in Brazil Associações entre malófagos (Insecta, Phthiraptera e albatrozes e petréis (Aves, Procellariiformes capturados no Brasil

    Directory of Open Access Journals (Sweden)

    Michel P. Valim

    2006-12-01

    Full Text Available Chewing lice were searched on 197 skins of 28 species of procellariiform birds collected in Brazil. A total of 38 species of lice were found on 112 skins belonging to 22 bird species. The lice were slide-mounted and identified. A list of lice species found and their host species is given and some host-louse associations are discussed under an evolutionary perspective.Malófagos foram procurados em 197 peles de 28 espécies de aves Procellariiformes capturadas no Brasil. Um total de 38 espécies de piolhos foram encontradas em 112 peles pertencentes a 22 espécies de aves. Os piolhos foram montados em lâminas e identificados. Uma lista com as espécies de piolhos encontradas e seus hospedeiros é dada, além de algumas associações entre os piolhos e as aves serem discutidas sob uma perspectiva evolutiva.

  7. Malaria diagnosis and treatment under the strategy of the integrated management of childhood illness (IMCI): relevance of laboratory support from the rapid immunochromatographic tests of ICT Malaria P.f/P.v and OptiMal

    DEFF Research Database (Denmark)

    Tarimo, D S; Minjas, J N; Bygbjerg, I C

    2001-01-01

    to be excluded as a cause of illness (e.g. prior to treatment with toxic or expensive drugs, or during malaria epidemics). Wherever the effective drugs for the first-line treatment of malaria are cheap (e.g. chloroquine and Fansidar), treatment based on clinical diagnosis alone should prove cost-saving in health...... significantly associated with the P. falciparum asexual parasitaemias that equalled or exceeded the threshold intensity (2000/microl) that has the optimum sensitivity and specificity for the definition of a malarial episode. Diagnostic likelihood ratios (DLR) showed that a positive result in the OptiMal test....... Although the RIT may seem attractive for use in primary health facilities because relatively inexperienced staff can perform them, the high cost of these tests is prohibitive. In holo-endemic areas, use of RIT or microscopical examination of bloodsmears may only be relevant when malaria needs...

  8. Malária em usuários de drogas de administração endovenosa associada à soropositividade para HIV The association of malaria, HIV seropositivity and intravenous administration in drug users

    Directory of Open Access Journals (Sweden)

    Shin Shiang Lo

    1991-02-01

    Full Text Available Infecções induzidas de malária têm sido verificadas nos últimos anos no Estado de São Paulo, Brasil concomitantemente com o aumento de casos importados procedentes da região endêmica do país. Destaca-se o registro de um caso em 1988 e onze casos em 1989 de malária induzida por Plasmodium vivax, em indivíduos residentes na cidade de Presidente Prudente, situada a oeste do Estado e considerada uma das "portas de entrada" de pessoas procedentes da Região Amazônica. Os pacientes afirmaram não terem se deslocado recentemente ou negaram deslocamentos para áreas com possibilidade de transmissão de malária. Todos fizeram uso de drogas injetáveis, participando de círculos de conhecidos afins e geralmente dividiam a mesma agulha e seringa no uso da cocaína. Foi detectado o doente de malária que transmitiu inicialmente a doença ao caso de 1988, e a um primeiro grupo de três indivíduos em 1989. Destes três casos, um transmitiu a doença a outro grupo de dois indivíduos em 1989. A partir destas primeiras infecções e do uso continuado das drogas injetáveis entre grupos, surgiram dois novos casos e houve reinfecção em dois indivíduos (um destes apresentou duas reinfecções. O exame para detecção de HIV foi positivo em cinco indivíduos, um apresentou resultado negativo e não foi realizado em outros três indivíduos. São analisadas as informações desses casos e discutida a importância de sua ocorrência no momento atual.Cases of induced malaria have been notified in S. Paulo State, Brazil, in recent years. At the same time the number of cases imported from endemic regions of Brazil has been increasing. One case of induced malaria by Plasmodium vivax was registered in Presidente Prudente, located in the west of the State, in 1988 and a further eleven cases in 1989. This city is considered to be one of the main transit ports for people who come into the State from the Amazonian region. The patients declared that they had

  9. Avaliação nutricional, produção e incidência do mal-do-panamá em bananeira 'Prata-Anã' (AAB adubada com K, no quarto ciclo

    Directory of Open Access Journals (Sweden)

    José Tadeu Alves da Silva

    2013-12-01

    Full Text Available O presente trabalho teve como objetivos estimar a dose de K para obter a máxima eficiência física e econômica, estimar o nível crítico foliar de K e relacionar o equilíbrio nutricional da bananeira 'Prata-Anã' com a incidência de plantas com mal-do-panamá no 4º ciclo. O experimento foi realizado em Latossolo Vermelho-Amarelo (LVA, textura média, na região semiárida do norte de Minas Gerais, Brasil. Os tratamentos consistiram nas aplicações de quatro doses de K (0; 400; 800 e 1.200 kg ha-1 ano de K2O. Estes foram distribuídos em blocos ao acaso, com cinco repetições. A adubação com K promoveu aumento na produção da bananeira no 4º ciclo. A máxima eficiência física (31 Mg ha-1 e a econômica (30,5 Mg ha-1 foram obtidas com as aplicações de 969 e 707 kg ha-1 ano-1 de K2O, respectivamente. Os níveis críticos foliares de K obtidos foram 29,5 e 27,1 g kg-1, para a máxima eficiência física e econômica, respectivamente. O aumento das doses de K proporcionou melhor equilíbrio nutricional à bananeira e reduziu a porcentagem de plantas infestadas com o mal-do-panamá.

  10. A proposal for an evaluation model of pharmaceutical services for malaria Uma proposta de modelo de avaliação para a assistência farmacêutica na malária

    Directory of Open Access Journals (Sweden)

    Claudia Garcia Serpa Osorio-de-Castro

    2009-09-01

    Full Text Available Malaria is a serious public health problem in over 90 countries worldwide. In Brazil the disease is prevalent in the Amazon and the control rationale is based on early diagnosis and treatment. Quality pharmaceutical services are considered a key element for control. A proposal for evaluating pharmaceutical services for malaria is presented here. A theoretical outline composed of a logical model and an indicator framework is discussed and strives to establish a basis for assessment and judgment of the way in which these services are actually delivered. The aim is to contribute to the understanding of pharmaceutical services for malaria and other endemic diseases, complying with the directives of the Brazilian National Medicines Policy.A malária é um grave problema de saúde pública em cerca de 90 países. No Brasil, a Amazônia congrega o maior número de casos. No país, o racional de enfrentamento se baseia em diagnóstico precoce e tratamento. A assistência farmacêutica de qualidade é considerada elemento-chave para o controle da doença. Apresenta-se uma proposta de avaliação da assistência farmacêutica, composta por um modelo lógico e uma grade de indicadores, discutidos de modo a estabelecer uma base de comparação e julgamento da forma na qual os serviços são ofertados. O objetivo é contribuir para o entendimento da assistência farmacêutica na malária e em outras endemias, atendendo às diretrizes da Política Nacional de Medicamentos.

  11. O Enigma do Mal: uma leitura do 'De casu diaboli'de Santo Anselmo (The enigma of evil: a reading of St. Anselm’s De casu diaboli - DOI: 10.5752/P.2175-5841.2013v11n32p1551

    Directory of Open Access Journals (Sweden)

    Manoel Luís Cardoso Vasconcellos

    2013-12-01

    Full Text Available O presente artigo quer investigar o problema do mal na perspectiva de Santo Anselmo, tomando como ponto de partida sua obra De casu diaboli, onde o tema é abordado, a partir da íntima ligação entre mal e pecado. Ao enfocar o mal na perspectiva da queda diabólica, o Doutor Magnífico intenta mostrar a conexão entre vontade, liberdade e justiça. Sua preocupação é investigar o significado moral da má escolha, realizada por uma criatura racional e puramente espiritual, feita boa e para ser boa. O pecado, consoante o autor, não está em almejar a felicidade, pois tal desejo é dádiva divina; o mal praticado pelo anjo está, precisamente, em querer a felicidade fora da justiça, isto é, ao querer ser feliz, ele foi de encontro ao que ele deveria ser: quis ser semelhante a Deus, extrapolando a sua própria natureza, pois ele desejou algo que, enquanto criatura, não caberia a ele almejar. Este é o ponto de partida para analisar o mal e sua mais dramática consequência, o sofrimento. Palavras-chave: Mal. Vontade. Justiça. Anselmo.   Abstract This article aims to investigate the problem of evil in Saint Anselm, especially in his treatise De casu diaboli. He approaches this issue from the close connection between evil and sin. Upon analyzing evil from the diabolic fall perspective, Dr. Magnificent tries to establish a connection between will, freedom and justice. This text investigates the moral meaning of misconduct, carried out by a rational and purely spiritual creature that was created good and meant to be good. Seeking for happiness is not itself a sin, according to the author, for such a wish is a gift from God. The evil done by the angel lies in the act of wanting happiness without justice, that is, on wanting to be happy, the angel contradicted what he was supposed to be: he wanted to be like God, transcending his own nature, as he wished for something that, as a creature, he was not fit to wish for. This is the starting point to

  12. Associação de eventos de vida produtores de estresse e mal-estar psicológico: um estudo de base populacional Association of stressful life events and psychological distress: a community-based study

    Directory of Open Access Journals (Sweden)

    Felipe Sparrenberger

    2004-02-01

    Full Text Available Foi realizado, em 1999, estudo transversal para investigar a associação entre determinados eventos produtores de estresse e a sensação de mal-estar psicológico. A Escala de Faces foi usada para medir o desfecho. A ocorrência de morte e doença em familiar, separação conjugal, roubo, acidente, migração e perda do emprego no ano anterior à entrevista, foi investigada entre 3.942 pessoas maiores de vinte anos de idade. A análise por regressão logística seguiu modelo hierárquico incluindo, no primeiro nível, características sócio-demográficas individuais; no segundo, eventos estressantes e, no terceiro, o mal-estar psicológico. Acidente e migração não se associaram ao desfecho. O maior efeito foi para separação conjugal (OR ajustada de 2,34. Os mais altos riscos atribuíveis na população foram os das variáveis sócio-econômicas (escolaridade 38,2% e renda 32,3% e o da ocorrência de pelo menos um dos eventos (36,4%. Atuação no plano das políticas públicas, visando a reduzir a ocorrência de eventos sociais negativos e, no plano individual, auxiliando as pessoas a lidar melhor com estes fatos da vida, poderiam contribuir para reduzir substancialmente a sensação de mal-estar psicológico.A cross-sectional study was conducted in 1999 to investigate the association between stressful psychosocial events and psychological distress. A Faces Scale was used to measure the outcome. Death and illness in the family, divorce, robbery, injury, migration, and loss of employment in the previous year were investigated through interviews with 3,942 individuals over 20 years. Logistic regression followed a hierarchical model using socio-demographic characteristics at the first level; psychosocial events at the second; and psychological distress at the third. Injury and migration were not associated with the outcome. The strongest effect was associated with divorce (adjusted OR = 2.34. The highest population-attributable risks were

  13. Comportamento epidemiológico da malária no Estado de Mato Grosso, 1980-2003 Epidemiological trends of malaria in the State of Mato Grosso, from 1980 to 2003

    Directory of Open Access Journals (Sweden)

    Marina Atanaka-Santos

    2006-04-01

    Full Text Available Descreveu-se a evolução temporal e espacial de malária em Mato Grosso, discriminadas em períodos de 1980-1985; 1986-1991; 1992-1997 e 1998-2003, distribuídas por microrregião homogênea. O índice parasitário anual do estado cresceu até 1992, reduzindo para 1,9 casos/mil habitantes em 2003; o coeficiente de mortalidade e a taxa de letalidade foram maiores nos anos de 1980 a 1989. Das 22 microrregiões, 13 apresentaram IPA inferior a 10 casos/1.000 habitantes em todos os períodos, ocorrendo concentração de casos nas microrregiões de Colíder, Alta Floresta, Aripuanã e Alto Guaporé. Em 2003, apenas a microrregião de Aripuanã persistia com IPA superior a 50 casos/1.000 habitantes. As microrregiões de Colíder, em 1983, 1985 a 1988 e 1990 e Alta Floresta, em 1991, apresentaram óbitos acima de 50/100.000 habitantes, sendo a maioria do sexo masculino, na faixa etária de 20 a 49 anos. A distribuição da doença por microrregiões evidenciou que a malária é predominantemente focal.The temporal and spatial evolution of malaria in Mato Grosso was determined in periods from 1980-1985, 1986-1991, 1992-1997 and 1998-2003 and distributed by homogeneous microregion. The annual parasitic index of the state rose until 1992 and then diminished to 1.9 cases/1,000 inhabitants in 2003, the ratio of mortality and the lethality rate were greater in the 1980s. Of the 22 microregions, 13 presented an API inferior to 10 cases/1,000 inhabitants in all periods. Cases were concentrated in the microregions of Colíder, Alta Floresta, Aripuanã and Alto Guaporé. In 2003, only the microregion of Aripuanã continued to present an API superior to 50 cases/1,000 inhabitants. The microregions of Colíder, in 1983, 1985 to 1988 and 1990 and Alta Floresta, in 1991 presented deaths over 50/100,000 inhabitants, mainly in males aged 20-49 years. The distribution of the disease in microregions showed that malaria is predominantly found in concentrated sites.

  14. Preliminary data from {gamma}-cardiography during the abatement of an asthmatic attack (1961); Premieres donnees de la {gamma}-cardiographie au decours de l'etat de mal asthmatique (1961)

    Energy Technology Data Exchange (ETDEWEB)

    Georges, R; Vernejoul, P de; Raynaud, C; Blanchon, P; Kellershohn, C; Turiaf, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1961-07-01

    The authors used gamma cardiology during the abatement of 16 cases of asthma with a view to detecting heart attacks not otherwise visible with routine methods of examination: clinical, radiological and electro-cardio-graphical. In gamma cardiology, a radioactive indicator is used and its path followed in the cavities of the heart. The method makes it possible to study the circulation in the right heart, the pulmonary crossing, and the left heart, as well as evaluation of the heart-flow. As a result of their investigations the authors, after having discussed the significance of the data obtained with the method, suggest that it is possible by the use of gamma cardiography during the abatement of an asthma attack: 1- To confirm attacks of the right heart which have already been detected by ordinary methods. 2- To confirm the presence of modifications in the recorded curves which suggest, in the case of the left heart, possible attack; such on attack is also indicated, in a small number of cases, by electrocardiography curves. Some considerations are put forward by the authors concerning the physiopathology of attacks on the left heart. (authors) [French] Les auteurs ont fait appel a la gammacardiographie au decours de 16 cas d'etat de mal asthmatique, dans le but d'objectiver des atteintes cardiaques incapables d'etre revelees par les moyens d'exploration de routine: cliniques, radiologiques et electrocardiographiques. La gammacardiographie est un procede qui enregistre a l'aide d'un indicateur radioactif, le trajet de celui-ci dans les cavites cardiaques. Elle permet l'etude de la circulation dans le coeur droit, de la traversee pulmonaire, et le coeur gauche, de meme que le calcul du debit cardiaque. Au terme de leurs investigations, les auteurs apres avoir discute la signification des donnees fournies par la methode admettent que la gammacardiographie objective au secours de l'etat de mal asthmatique: 1- La confirmation de l'atteinte du coeur droit deja etablie

  15. Retardo no crescimento intrauterino, baixo peso ao nascer e prematuridade em recém-nascidos de grávidas com malária, na Colômbia Intrauterine growth retardation, low birth weight and prematurity in neonates of pregnant women with malaria in Colombia

    Directory of Open Access Journals (Sweden)

    Alberto Tobón-Castaño

    2011-06-01

    Full Text Available INTRODUÇÃO: É frequente a associação da malária com complicações como prematuridade, retardo no crescimento intrauterino, baixo peso ao nascer e mortalidade infantil, efeitos pouco estudados em áreas hipoendêmicas para malaria. O objetivo deste estudo foi analisar a relação da malária gestacional com estes efeitos em recém-nascidosnuma região endêmica para malária na Colômbia, entre 1993 e 2007. MÉTODOS: Foram estudadas as características em 1.716 recém-nascidos num estudo de coorte. Fez-se seguimento em 394 gestantes com malária (27% por Plasmodium falciparum e 73% por P. vivax e 1.322 sem malária. RESULTADOS: Foi encontrada uma relação entre a exposição à malária na gestação e o risco maior de baixo peso ao nascer (RR = 1,37; 1,03-1,83, assim como estatura baixa (RR = 1,52; 1,25-1,85, retardo no crescimento intrauterino (RR = 1,29; 1,0-1,66 e prematuridade (RR = 1,68; 1,3-2,17. A frequência de nascimentos prematuros foi maior nas mães com malária por P. falciparum (77% que aquelas com P. vivax (RR = 1,77; IC 95%: 1,2-2,6. CONCLUSÕES: O baixo peso ao nascer e o retardo no crescimento foi associado com malária na gestação na Colômbia. A infecção por P. vivax foi relacionada com efeitos adversos sobre o recém-nascido, de modo semelhante em relação ao P. falciparum.INTRODUCTION: Association between malaria and pregnancy complications, such as prematurity, intrauterine growth restriction, low birthweight and infant mortality has been reported. These effects have been studied widely in areas hyperendemic for malaria, but studies in low-endemic areas are scarce. The study investigated the relation between gestational malaria and low birthweight and intrauterine growth retardation in neonates of a malarial endemic region in Colombia, between 1993 and 2007. METHODS: The pattern of development in 1,716 neonates of women with and without malaria infection during pregnancy was evaluated in a cohort study. A

  16. Intervención familiar para el manejo psicológico en pacientes oncológicos con mal pronóstico en el hospital de la Misericordia

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    Ana Carolina Rodríguez Ibarra

    2004-01-01

    Full Text Available Se diseñó un programa fundamentado en el modelo cognitivo conductual de Inoculación de Estrés e intervención en duelo anticipatorio basado en cuatro tareas. El programa fue aplicado a tres pacientes con mal pronóstico del Servicio de Oncohematología del Hospital de la Misericordia y a sus familias. Por medio de estudio de caso, se describieron factores de riesgo y de protección así como respuestas frente a dicha intervención. El análisis cualitativo de casos arrojó la descripción de respuestas a pérdidas previas no elaboradas, pautas de comunicación deficiente en uno de los casos, y reconocimiento de apoyo al interior de cada familia. Según el reporte de los participantes, la intervención permitió la expresión de sentimientos, la reflexión sobre el sentido de la vida, incremento de posibilidades y habilidades de comunicación y orientación hacia la solución de problemas y toma de decisiones.

  17. Intrinsic magnetic properties of Sm{sub 2}Fe{sub 17-x}M{sub x}N{sub y}/C{sub y} (M=Al, Ga or Si)

    Energy Technology Data Exchange (ETDEWEB)

    Kubis, M.; Eckert, D.; Gebel, B.; Mueller, K.-H. E-mail: khm@ifw-dresden.de; Schultz, L

    2000-07-01

    Curie temperature T{sub c}, saturation polarization J{sub s} and anisotropy field H{sub a} of Sm{sub 2}Fe{sub 17-x}M{sub x}N{sub y}/C{sub y} with M=Al, Ga or Si (x{<=}3, y{approx}3) were determined by thermomagnetic measurements and a numerical fitting procedure of demagnetization curves. An increasing amount of the substitutional element M leads to an increase of T{sub c} of the Sm{sub 2}Fe{sub 17-x}M{sub x} parent compounds and generally to a decrease of T{sub c}, J{sub s} and H{sub a} for the interstitial nitrides and carbides. However, for small M contents, x{<=}1, an increased H{sub a} was observed compared to the substitution-free interstitial compounds. Gas-carburized and melt-carburized Sm{sub 2}Fe{sub 15}Ga{sub 2}C{sub y} samples showed large differences in J{sub s} and H{sub a} but identical T{sub c} values.

  18. Influence of M=Al, Ga and Si on microstructure and HDDR-processing of Sm2(Fe,M)17 and magnetic properties of their nitrides and carbides

    International Nuclear Information System (INIS)

    Kubis, M.; Gutfleisch, O.; Gebel, B.; Mueller, K.-H.; Schultz, L.

    1999-01-01

    Microstructural investigations by means of scanning electron microscopy and X-ray diffraction showed that the formation of high amounts of α-Fe in as-cast Sm 2 (Fe,M) 17 alloys can be suppressed by using the substitutions M=Al or Si together with excess Sm. Ga, on the other hand, does not induce this beneficial effect. The hydrogen absorption and desorption behaviour was investigated by temperature-pressure-analysis and hydrogen differential thermal analysis. Decreasing amounts of hydrogen were absorbed in Sm 2 (Fe,M) 17 for increasing contents of all substitutions M=Ga, Al and Si due to their stabilising effect on the 2:17 phase with regard to its disproportionation. Compared with the homogenised alloys, the as-cast materials show a weaker interstitial hydrogen absorption and a stronger disproportionation reaction at lower temperatures due to the higher content of Sm-rich phases in the as-cast alloys. A second cycle of the hydrogenation-disproportionation-desorption-recombination (HDDR) process leads to a faster disproportionation reaction at lower temperatures due to the grain refinement during the first cycle. Magnetic properties of as-cast and homogenised materials were investigated after HDDR treatment and nitrogenation or carburisation of pre-milled powders. Nitrogenated and carburised samples showed coercivities up to 3.0 T and 2.3 T, respectively. There were only slight differences of the magnetic properties of materials prepared from homogenised and from as-cast samples. (orig.)

  19. Evaluación de la válvula de Ahmed en el glaucoma de mal pronóstico quirúrgico Evaluation of Ahmed valve in the glaucoma of poor surgical prognosis

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    Francisco García González

    2001-12-01

    Full Text Available Se intervinieron 8 pacientes con glaucoma de mal pronóstico quirúrgico a los que se les implantaron una válvula de Ahmed con la técnica quirúrgica convencional. Se logró controlar la presión intraocular (PIO. Las complicaciones fueron: hipotonía (75 %, desprendimiento coroideo (37,5 %, hifema (25,0 %, contacto tubo iridiano (25, 0 %, hipotalamia (12,5 % y congestión en el área del implante (12,5 %. No hubo complicaciones intraoperatorias. Se obtuvieron resultados satisfactorios a mediano plazo.8 patients with glaucoma of poor surgical prognosis were implanted an Ahmed valve by using the conventional surgical technique. It was possible to control the intraocular pressure (IOP. The complications were: hypotony (75 %, choroidal detachment (37.5 %, hyphaemia (25.0 %, contact with the iridian tube (25.0 %, hypothalamia (12.5 % and congestion in the area of the implantation (12.5 %. There were no intraoperative complications. Medium term results were satisfactory.

  20. Ionic conductivity of the lithium titanium phosphate (Li/sub 1+x/M/sub x/Ti/sub 2-x/(PO/sub 4/)/sub 3/, M=Al, Sc, Y, and La) systems

    International Nuclear Information System (INIS)

    Aono, H.; Sugimoto, E.; Sadaaka, Y.; Imanaka, N.; Adachi, G.Y.

    1989-01-01

    High lithium ionic conductivity was obtained in Li/sub 1+X/M/sub X/Ti/sub 2-X/(PO/sub 4/)/sub 3/ (M=Al, Sc, Y, and La) systems. Lithium titanium phosphate, LiTi/sub 2/(PO/sub 4/)/sub 3/, is composed of both TiO/sub 6/ octahedra and PO/sub 4/ tetrahedra, which are linked by corners to form a three dimensional network, with a space group R3-barC. Some workers have already described that the conductivity increased considerably if Ti/sup 4+/ in LiTi/sub 2/(PO/sub 4/)/sub 3/ was substituted by slightly larger cations such as Ga/sup 3+/(1),Sc/sup 3+/(2), and In/sup 3+/(3,4). These results are similar to each other because of their close ionic radii. In this communication, substitution effects of Ti/sup 4+/ in LiTi/sub 2/(PO/sub 4/)/sub 3/ by various ions (Al/sup 3+/, Sc/sup 3+/, Y/sup 3+/, and La/sup 3+/) on their conductivities are reported

  1. Problematika zálohování a uchovávání dat v malých a středních podnicích

    OpenAIRE

    Hrach, Vlastimil

    2009-01-01

    Tato bakalářská práce upozorňuje na hojně opomíjenou důležitost firemních dat a jejich ochranu. Seznamuje s procesem zálohování jako základním prvkem bezpečnosti a efektivnosti informačního systému. Prezentuje výsledky mezinárodních studií na téma „Cena ztracených dat“, popisuje technologie diskových polí RAID, obecnou topologii LAN sítí a technologie DAS, NAS a SAN. Součástí práce jsou základní i pokročilé metody zálohování vhodné pro malé a střední podniky, v závislosti na jejich potřebě a ...

  2. The MAL-ED Cohort Study: Methods and Lessons Learned When Assessing Early Child Development and Caregiving Mediators in Infants and Young Children in 8 Low- and Middle-Income Countries

    Science.gov (United States)

    Murray-Kolb, Laura E.; Rasmussen, Zeba A.; Scharf, Rebecca J.; Rasheed, Muneera A.; Svensen, Erling; Seidman, Jessica C.; Tofail, Fahmida; Koshy, Beena; Shrestha, Rita; Maphula, Angelina; Vasquez, Angel Orbe; da Costa, Hilda P.; Yousafzai, Aisha K.; Oria, Reinaldo B.; Roshan, Reeba; Bayyo, Eliwasa B.; Kosek, Margaret; Shrestha, Sanjaya; Schaefer, Barbara A.; Bessong, Pascal; Ahmed, Tahmeed; Lang, Dennis

    2014-01-01

    More epidemiological data are needed on risk and protective factors for child development. In The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) cohort study, we assessed child development in a harmonious manner across 8 sites in Bangladesh, Brazil, India, Nepal, Pakistan, Peru, South Africa, and Tanzania. From birth to 24 months, development and language acquisition were assessed via the Bayley Scales of Infant and Toddler Development and a modified MacArthur Communicative Development Inventory. Other measures were infant temperament, the child's environment, maternal psychological adjustment, and maternal reasoning abilities. We developed standard operating procedures and used multiple techniques to ensure appropriate adaptation and quality assurance across the sites. Test adaptation required significant time and human resources but is essential for data quality; funders should support this step in future studies. At the end of this study, we will have a portfolio of culturally adapted instruments for child development studies with examination of psychometric properties of each tool used. PMID:25305296

  3. Biologia de anofelinos amazônicos: XII. Ocorrência de espécies de Anopheles, dinâmica da transmissão e controle da malária na zona urbana de Ariquemes (Rondônia

    Directory of Open Access Journals (Sweden)

    Wanderli Pedro Tadei

    1988-06-01

    Full Text Available Dados sobre o grau de incidência e distribuição de espécies Anopheles, em Ariquemes (RO, evidenciaram que a diversidade é maior na periferia da cidade e que Anopheles darlingi é registrada em praticamente todas as localidades de coleta. O inquérito entomológico revelou níveis diferentes de penetração da espécie na área urbana, podendo-se constatar que os Setores 1 e 3 são áreas livres de malária; Setores 2 e 4 mostram riscos na periferia; e a Área Industrial e Setor de Áreas Especiais, Conjunto BNH, Setor 5 e Vila Velha constituem áreas de alto risco da malária. Nestes últimos, os índices de mosquitos por homem/hora foram os mais elevados, observando-se variações no decorrer das amostragens e conforme a localização da área urbana. Medidas de densidade populacional revelaram mudanças estacionais, sendo os menores valores registrados no período de inverno. A transmissão da malária é discutida, considerando-se: 1 o papel da estrutura física da cidade, na época da fundação, 2 os igarapés que margeam a área urbana e suas relações com o ciclo de desenvolvimento dos anofelinos, 3 os padrões comportamentais da atividade de picar das espécies correlacionados a ambientes naturais e às áreas ecologicamente alteradas, e 4 a importância do manuseio ambiental no controle da malária, para redução da densidade populacional. Para conter o processo migratório do vetor é proposto um cinturão de proteção à cidade, constituído de mata não densa, incluindo também proteção biológica para incentivar a zoofilia dos anofelinos. Os resultados de infecção natural, obtidos em áreas de autoctonia da malária, permitem citar A. darlingi como vetor, sendo discutida a possibilidade de que outras espécies estejam envolvidas na transmissão.

  4. Tiroidectomia total en afecciones benignas de la glándula tiroides.

    OpenAIRE

    Lucena Olavarrieta, Jorge R.; Coronel, Paúl; Orellana, Ysabelen

    2006-01-01

    Editorial. ¡Ya tenemos símbolo, ícono o logotipo!. Now we have symbol, icono or logo!. Salinas, Pedro José Accidentes domésticos en ancianos. Municipio Libertador. Mérida. 1993-1996. Domestics accidents in elderly people. Libertador County of Mérida State. 1993-1996. Salinas, Pedro José Rojas Márquez, Reina Estrés y síntomas en personal de salud del Hospital Universitario de Los Andes. Stress and symptoms in health staff of the Hospital Universitario de Los Andes. Méri...

  5. Hipertrofia benigna do músculo masseter Benign masseter muscle hypertrophy

    Directory of Open Access Journals (Sweden)

    Daniel Zeni Rispoli

    2008-10-01

    Full Text Available A hipertrofia idiopática do músculo masseter (HIM é uma patologia pouco freqüente e de causa desconhecida. Alguns autores correlacionam tal condição com hábitos de mascar gomas, disfunção da articulação temporomandibular (ATM, hipertrofias congênitas e funcionais, e distúrbios emocionais (nervosismo e ansiedade. A maioria dos pacientes queixa-se da alteração estética decorrente da assimetria facial, também chamada "face quadrada", no entanto, sintomas como trismo, protrusão e bruxismo também podem ocorrer. Os objetivos deste estudo foram: relatar um caso de HIM e descrever a sintomatologia e o tratamento realizado. O paciente relatava aumento bilateral na região do ângulo da mandíbula de evolução lenta e progressiva. Negava dor ou desconforto, porém se queixava de otalgia bilateral, trismo noturno e ansiedade. Ao exame físico, observou-se hipertrofia bilateral de masseter sem alterações inflamatórias no local. Foi indicado tratamento cirúrgico com abordagem extra-oral. Exames complementares são indicados na dúvida diagnóstica. A conduta terapêutica varia de conservadora a cirúrgica, sendo que esta depende principalmente da experiência e da habilidade do cirurgião.Idiopathic hypertrophy of the masseter muscle is a rare disorder of unknown cause. Some authors associate it with the habit of chewing gum, temporo-mandibular joint disorder, congenital and functional hypertrophies, and emotional disorders (stress and nervousness. Most patients complain of the cosmetic change caused by facial asymmetry, also called square face, however, symptoms such as trismus, protrusion and bruxism may also occur. The goals of the present investigation were: to report a case of idiopathic masseter hypertrophy, describe its symptoms and treatment. The patient reported bilateral bulging in the region of the mandible angle, of slow and progressive evolution. He did not complain of pain or discomfort, however there was bilateral otalgia, nighttime trismus and stress. In his physical exam we noticed bilateral masseter hypertrophy without local inflammatory alterations. We indicated surgical treatment with an extraoral approach. Complementary tests are indicated when there is diagnostic doubts. Treatment varies from conservative to surgical, and the later depends on surgeon skill and experience.

  6. Pharmacological treatment of the benign prostatic hyperplasia; Tratamiento farmacologico en la hiperplasia prostatica benigna

    Energy Technology Data Exchange (ETDEWEB)

    Perez Guerra, Yohani; Molina Cuevas, Vivian; Oyarzabal Yera, Ambar; Mas Ferreiro, Rosa, E-mail: yohani.perez@cnic.edu.c [Centro de Productos Naturales, Centro Nacional de Investigaciones Cientificas (CNIC), La Habana (Cuba)

    2011-07-01

    Benign prostatic hyperplasia is a common disease in over 50 years-old men consisting in uncontrolled and benign growth of prostatic gland that leads to lower urinary tract symptoms. The etiology of benign prostatic hyperplasia is multifactoral involving the increased conversion of testosterone in dihydrotestosterone by the prostatic 5{alpha}-reductase action, which brought about events that encourage the prostate growth (static component) and the increase of the bladder and prostate smooth muscle tone (dynamic component) regulated by the a{alpha}{sub 1} -adrenoceptors (ADR). The pharmacological treatment of the benign prostatic hyperplasia includes the prostatic 5a{alpha}-reductase inhibitors, the a{alpha}{sub 1}-adrenoreceptor blockers, their combined therapy and the phytotherapy. This paper was aimed at presenting the most relevant aspects of the pharmacology of drugs used for treating the benign prostatic hyperplasia, and providing elements to analyze their efficacy, safety and tolerability. To this end, a review was made of the different drugs for the treatment of this pathology and they were grouped according to their mechanism of action. Natural products were included as lipid extracts from Serenoa repens and Pygeum africanum as well as D-004, a lipid extract from Roystonea regia fruits, with proved beneficial effects on the main etiological factors of benign prostatic hyperplasia. D-004 is a prostatic 5a-reductase inhibitor, an a{alpha}{sub 1}-adrenoceptor antagonist, a{alpha} 5-lipooxygenase inhibitor and has antioxidant action, all of which reveals a multifactoral mechanism. The results achieved till now indicate that D-004 is a safe and well-tolerated product

  7. Endometriose intestinal: uma doença benigna? Bowel endometriosis: a benign disease?

    Directory of Open Access Journals (Sweden)

    Marco Antonio Bassi

    2009-01-01

    Full Text Available A despeito do caráter benigno da endometriose, estima-se que 1% dos casos esteja relacionado com câncer, especialmente quando ambas as condições ocorrem nos ovários. Lesões extra-ovarianas encontradas no septo retovaginal, cólon, bexiga, vagina e peritônio da região pélvica também já foram associadas com neoplasias malignas. Várias características do tecido endometrial ectópico o aproximam do fenótipo neoplásico, e a própria endometriose possui comportamento tipicamente neoplásico com capacidade de invasão do estroma adjacente e associação com lesões à distância. Esta revisão atualiza conhecimentos diagnósticos, clínicos e terapêuticos dos implantes intestinais de tecido endometriótico, bem como sua relação com processos neoplásicos para melhor compreensão de seu caráter benigno ou de seu eventual potencial para malignidade.Endometriosis is generally assumed to be a benign disease, but it is estimated that 1% of cases are associated with cancer, especially when both conditions are present in the ovary. Extra-ovarian lesions in the rectovaginal septum, colon, bladder, vagina and peritoneum were already associated with malign neoplasia. Several characteristics of endometrial tissue are very similar to the neoplasia phenotype. Endometriosis itself typically behaves as a neoplasia process, spreading over adjacent stroma and being associated with distant lesions. This is an update on the diagnostic, clinical, and therapeutic knowledge of, management of bowel implants of endometrial tissue, as well as the relation with neoplastic processes to better understand its benign nature or eventual potential for malignancy.

  8. ENFERMIDADES DIAGNOSTICADAS NA GENITÁLIA EXTERNA DE TOUROS: ESTUDO RETROSPECTIVO (2007 – 2013

    Directory of Open Access Journals (Sweden)

    Luiz Antônio Franco da Silva

    2015-01-01

    Full Text Available Despite the importance of knowing epidemiological data on diseases that affect the external genitalia of bulls, few investigations have been conducted on the topic. This work aimed to conduct an epidemiological study of diseases diagnosed in the external genitalia of bulls in 215 farms distributed in the five mesoregions of the state of Goiás, Brazil, between 2007 and 2013. We verified that the largest number of cases were observed at southwestern region (64 %, followed by the northwestern region (18.5 %. We found that of the affected bulls, 156 (71.89 % were Zebu, 47 (21.66% taurine and 14 (6.45 % were mixed breeds. Among the diseases, acropostite-phimosis was the more frequent, followed by fibropapiloma of the glans, prepuce abscess and penile fracture. The main risk factors were multifactorial aspects, including the morphological condition of the animals, environment, management and traumas. In many cases, the absence or insufficient number of trained veterinarians who work on the field was mentioned as one of the major bottlenecks for the realization of the diagnosis, treatment and prevention of diseases, preventing premature disposal of the animals.

  9. Tricocefalosis masiva en un adulto diagnosticada por colonoscopía

    OpenAIRE

    Sapunar, Jorge; Gil, Luis Carlos; Gil, José Germán

    1999-01-01

    A case of massive trichuriasis in a 37-year-old female from a rural locality of the Metropolitan Region of Chile, with antecedents of alcoholism, chronic hepatic damage and portal cavernomatosis, is presented. Since 12 year ago she has had geophagia. In the last six months she has frequently presented liquid diarrhea, colic abdominal pains, tenesmus and sensation of abdominal distention. Clinical and laboratory tests confirmed her hepatic affection associated with a celiac disease with anemia...

  10. Eletromiografia laríngea e análise vocal em pacientes com Mal de Parkinson: estudo comparativo Laryngeal electromyography and acoustic voice analysis in Parkinson's disease: a comparative study

    Directory of Open Access Journals (Sweden)

    Ana Paula Zarzur

    2010-02-01

    Full Text Available A doença ou Mal de Parkinson se deve à deficiência dopaminérgica nos núcleos da base que geram alterações motoras. Comprometimento da comunicação verbal ocorre em 70 a 90% dos doentes. Existem poucas referências da aplicação da eletromiografia no estudo dos músculos laríngeos em pacientes com a doença de Parkinson. OBJETIVOS: Definir o padrão contrátil da musculatura intrínseca da laringe e sua correlação com a análise acústica vocal nos parkinsonianos. CASUÍSTICA E MÉTODO: Estudo prospectivo onde 26 adultos com o diagnóstico de Mal de Parkinson foram submetidos à eletromiografia laríngea e análise acústica vocal. Foram coletados potenciais de ação, tanto em repouso vocal quanto em fonação. Para a análise acústica da voz foram utilizados os programas VOXMETRIA® e GRAM 5.1.6®. RESULTADOS: O padrão eletromiográfico predominante no grupo estudo foi o de hipercontratibilidade (ou recrutamento aumentado durante repouso vocal que ocorreu em 73% dos indivíduos, sem que houvesse registro eletromiográfico de tremor. Quanto às características vocais, detectou-se a presença de tremor vocal no traçado do espectrograma (VOXMETRIA E GRAM e na avaliação perceptivo-auditiva em 69,5 % e 61 % dos sujeitos, respectivamente. CONCLUSÃO: O tremor vocal foi a característica acústica predominante no grupo estudado, sem que houvesse correlação eletromiográfica.Parkinson's disease (PD involves a progressive depletion of dopamine in the basal ganglia leading to motor alterations. Oral communication impairment occurs in 75% to 90% of patients and has been poorly studied. AIM: to asses laryngeal electromyography (LEMG patterns and correlate them to vocal analysis in patients with Parkinson's disease. MATERIALS AND METHODS: This is a prospective study. Twenty six adults with PD underwent laryngeal electromyography. Rest and phonation potentials were analyzed. VOXMETRIA® and GRAM 5.1.6. ® were used in acoustic analysis

  11. A crítica de Alexis Philonenko ao "mal-estar" sartriano: em defesa do humanismo The criticism of Alexis Philonenko to the sartrian's malaise: in defense of the humanism

    Directory of Open Access Journals (Sweden)

    Malcom G Rodrigues

    2010-01-01

    Full Text Available O objetivo do artigo é discutir a crítica de Philonenko (1981 aos conceitos sartrianos de "má-fé" e "liberdade". Um dos pilares dessa crítica é a defesa da noção de "coerência do estilo", elemento indispensável para resguardar a autenticidade tão prezada por Sartre, segundo Philonenko. Contudo, continua este último, ao afirmar "eu não sou jamais nenhuma de minhas condutas, nenhuma de minhas atitudes", Sartre limita a liberdade por ele defendida ao horizonte de uma maliciosa dissimulação, quer dizer, da má-fé. Nós constatamos três imprecisões nessa crítica. Em primeiro lugar, a citada afirmação de Sartre foi mal interpretada. Mas, em segundo, se essa interpretação está correta, supondo que o estilo seja indispensável à autenticidade, ainda assim a liberdade sartriana não pode ser "para o mal", pois ela se caracteriza, em termos ontológicos, como o próprio ser da realidade humana "em situação", e não em termos morais, como uma propriedade dessa realidade, cristalizada por um olhar atento sobre si ou sobre o outro, e julgada como boa ou má. Por fim, queremos concluir que, numa possível conduta autêntica, a derrocada da má-fé não apenas prescinde do amparo a uma coerência do estilo como também pressupõe o reconhecimento angustiante de sua gratuidade.The aim of this paper is to discuss the Philonenko's criticism (1981 to the sartrian's concepts of "bad-faith" and "freedom". One of the pillars of this criticism is to defend the notion of "coherence of style", an indispensable element to safeguard the authenticity so relevant for Sartre, according Philonenko. However, when Sartre says "I'm not ever any of my conduct, none of my actions", limits the freedom advocated by himself on the horizon of a malicious deception, that is, the horizon of bad- faith. We found three inaccuracies in this criticism. First, the statement aforementioned of Sartre was misinterpreted. But secondly, if this interpretation is correct

  12. Mal-Development of the Penis and Loss of Fertility in Male Rats Treated Neonatally with Female Contraceptive 17α-Ethinyl Estradiol: A Dose-Response Study and a Comparative Study with a Known Estrogenic Teratogen Diethylstilbestrol

    Science.gov (United States)

    Mathews, Ensa; Braden, Tim D.; Williams, Carol S.; Williams, John W.; Bolden-Tiller, Olga; Goyal, Hari O.

    2009-01-01

    The objectives of this study were to find a minimal dose of 17α-ethinyl estradiol (EE) that is detrimental to the developing penis and fertility and to compare estrogenic effects between EE and diethylstilbestrol (DES). Neonatal rats received EE at 10 ng (1 μg/kg), 100 ng, 1 μg, or 10 μg per pup on alternate days from postnatal days 1 to 11 (dose-response study) or received EE or DES at 100 ng per pup daily from postnatal days 1 to 6 (comparative study). Effects of EE were dose dependent, with ≥ 100-ng dose inducing significant (p penis was malformed, characterized by underdeveloped os penis and accumulation of fat cells. Fertility was 0% in the ≥ 1-μg groups, in contrast to 60% in the 100-ng group and 100% in the 10-ng and control groups. Animals treated with ≥ 10 ng had significant reductions in the weight of bulbospongious muscle, testis, seminal vesicle, epididymal fat pad, and in epididymal sperm numbers. A comparison of EE and DES effects showed similar reductions in penile weight and length and the weight of bulbospongiosus muscle, testis, seminal vesicle, epididymis, and epididymal fat pad in both adolescent and adult rats. While 5/6 control males sired, only 1/6 in the EE group and 0/6 in the DES group sired. Hence, neonatal exposure to EE at 10 ng (environmentally relevant dose) adversely affects male reproductive organs. A dose ten times higher than this leads to permanently mal-developed penis and infertility. Furthermore, EE and DES exposures show similar level of toxicity to male reproductive organs. PMID:19729556

  13. Influence of M=Al, Ga and Si on microstructure and HDDR-processing of Sm{sub 2}(Fe,M){sub 17} and magnetic properties of their nitrides and carbides

    Energy Technology Data Exchange (ETDEWEB)

    Kubis, M.; Gutfleisch, O.; Gebel, B.; Mueller, K.-H.; Schultz, L. [Institut fuer Festkoerper- und Werkstofforschung Dresden e.V. (Germany). Inst. fuer Metallische Werkstoffe; Harris, I.R. [School of Metallurgy and Materials, University of Birmingham, Birmingham, B15 2TT (United Kingdom)

    1999-02-01

    Microstructural investigations by means of scanning electron microscopy and X-ray diffraction showed that the formation of high amounts of {alpha}-Fe in as-cast Sm{sub 2}(Fe,M){sub 17} alloys can be suppressed by using the substitutions M=Al or Si together with excess Sm. Ga, on the other hand, does not induce this beneficial effect. The hydrogen absorption and desorption behaviour was investigated by temperature-pressure-analysis and hydrogen differential thermal analysis. Decreasing amounts of hydrogen were absorbed in Sm{sub 2}(Fe,M){sub 17} for increasing contents of all substitutions M=Ga, Al and Si due to their stabilising effect on the 2:17 phase with regard to its disproportionation. Compared with the homogenised alloys, the as-cast materials show a weaker interstitial hydrogen absorption and a stronger disproportionation reaction at lower temperatures due to the higher content of Sm-rich phases in the as-cast alloys. A second cycle of the hydrogenation-disproportionation-desorption-recombination (HDDR) process leads to a faster disproportionation reaction at lower temperatures due to the grain refinement during the first cycle. Magnetic properties of as-cast and homogenised materials were investigated after HDDR treatment and nitrogenation or carburisation of pre-milled powders. Nitrogenated and carburised samples showed coercivities up to 3.0 T and 2.3 T, respectively. There were only slight differences of the magnetic properties of materials prepared from homogenised and from as-cast samples. (orig.) 21 refs.

  14. A importância do perfil clínico-laboratorial no diagnóstico diferencial entre malária e hepatite aguda viral Importance of clinical and laboratory profiles for the differential diagnosis of malaria and acute viral hepatitis

    Directory of Open Access Journals (Sweden)

    Cacyane Naiff do Amaral

    2003-10-01

    Full Text Available OBJETIVOS: Destacar o perfil clínico-laboratorial de malária e hepatite aguda viral em dois grupos de crianças, ressaltando semelhanças e diferenças entre os dois quadros; subsidiar o aumento da sensibilidade clínica de presunção diagnóstica precoce de malária na infância. MÉTODOS: Foram estudados dois grupos de 30 crianças, de dois a dez anos de idade, portadoras de primo infecção malárica ou hepatite viral aguda, confirmados pela pesquisa de plasmódio e pesquisa de marcadores virais de hepatite A e B. As crianças foram submetidas às seguintes avaliações no primeiro dia de atendimento: hemograma, contagem de plaquetas, dosagem de enzimas hepáticas, uréia, creatinina e bilirrubinas. Os achados clínicos e laboratoriais foram descritos e comparados entre os dois grupos. Proporções de indivíduos com exames físicos alterados foram comparadas nos dois grupos, pelo teste exato de Fisher. RESULTADOS: A apresentação clínica inicial da doença foi semelhante em todos os pacientes: febre, cefaléia, sintomas digestivos e colúria. Metade dos portadores de malária não apresentou a tríade clássica, apesar de todos terem apresentado febre moderada ou alta, ao contrário dos portadores de hepatite. Na avaliação laboratorial, os portadores de malária apresentaram mais anemia e plaquetopenia quando comparados aos portadores de hepatite. Foram marcantes, nos portadores de hepatite, as elevações de bilirrubinas e enzimas hepáticas. CONCLUSÕES: A propedêutica detalhada e a avaliação criteriosa dos exames laboratoriais inespecíficos constituem peças fundamentais para a diferenciação clínica entre os dois diagnósticos, reforçando a identificação precoce do parasita e, conseqüentemente, o tratamento rápido de malária em crianças.OBJECTIVE: To establish clinical and diagnostic findings of malaria and acute viral hepatitis in children, stressing similarities and differences, so as to enhance the sensitivity of

  15. The MAL-ED study: a multinational and multidisciplinary approach to understand the relationship between enteric pathogens, malnutrition, gut physiology, physical growth, cognitive development, and immune responses in infants and children up to 2 years of age in resource-poor environments.

    Science.gov (United States)

    2014-11-01

    Highly prevalent conditions with multiple and complex underlying etiologies are a challenge to public health. Undernutrition, for example, affects 20% of children in the developing world. The cause and consequence of poor nutrition are multifaceted. Undernutrition has been associated with half of all deaths worldwide in children aged Malnutrition and the Consequences for Child Health (MAL-ED) Study, led by the Fogarty International Center of the National Institutes of Health and the Foundation for the National Institutes of Health, has been established at sites in 8 countries with historically high incidence of diarrheal disease and undernutrition. Central to the study is the hypothesis that enteropathogen infection contributes to undernutrition by causing intestinal inflammation and/or by altering intestinal barrier and absorptive function. It is further postulated that this leads to growth faltering and deficits in cognitive development. The effects of repeated enteric infection and undernutrition on the immune response to childhood vaccines is also being examined in the study. MAL-ED uses a prospective longitudinal design that offers a unique opportunity to directly address a complex system of exposures and health outcomes in the community-rather than the relatively rarer circumstances that lead to hospitalization-during the critical period of development of the first 2 years of life. Among the factors being evaluated are enteric infections (with or without diarrhea) and other illness indicators, micronutrient levels, diet, socioeconomic status, gut function, and the environment. MAL-ED aims to describe these factors, their interrelationships, and their overall impact on health outcomes in unprecedented detail, and to make individual, site-specific, and generalized recommendations regarding the nature and timing of possible interventions aimed at improving child health and development in these resource-poor settings. Published by Oxford University Press on

  16. La desaparición forzada de personas: análisis crítico del derecho administrativo colombiano a través de los estándares del sistema interamericano de protección de derechos humanos. Estudio de caso de los mal llamados “falsos positivos”

    OpenAIRE

    Quintero Mendoza, Juan Sebastián

    2016-01-01

    La categorización jurídica de los mal llamados “falsos positivos” en Colombia es un tema controversial: en algunas ocasiones se habla de ejecuciones extrajudiciales, otras veces de homicidio en persona protegida y en otros casos de desapariciones forzadas, dependiendo de la institución que juzgue los casos. Ahora bien, al no existir unidad de criterios en la categorización jurídica de los “falsos positivos”, se hace imprescindible la integración de conceptos en torno a entender dichos hechos...

  17. Construindo o estado de conhecimento do bem-estar e mal-estar docente na revista de educação da PUCRS = Building the state of knowledge of teachers well-being and burnout in "Revista Educação" of PUCRS

    Directory of Open Access Journals (Sweden)

    Pinheiro, Leandro Brum

    2011-01-01

    Full Text Available A imprensa atual tem retratado diversas situações de professores e alunos em alto nível de mal-estar: stress, violência, rendimento baixo nas avaliações institucionais, perda do valor da profissão docente, entre outros. Todavia, a Academia tem resgatado também as diversas tentativas de compreensão e promoção do bem-estar na escola. A Pontifícia Universidade Católica do Rio Grande do Sul, através da Revista Educação, tem tratado destes dois temas com séria análise contextual e profundidade científica, sendo por isso escolhida como a fonte de pesquisas deste artigo. Com o fim de analisar a construção do estado de conhecimento do bem-estar e mal-estar docente na citada revista, tomamos desde o primeiro caderno publicado (1978 até o mais recente (2009, selecionando os artigos sobre as temáticas e organizando-os em seis categorias: a década em que foi escrito, os autores e suas universidades de origem, a classificação dos artigos em resultados de pesquisa ou de revisão bibliográfica, os autores mais citados e a temática dominante – o bem-estar ou o mal-estar docente. A partir das categorizações levantadas para os nove artigos selecionados, observou-se que a produção destes começou a se tornar mais frequente a partir dos anos 90, em especial com contribuições de professores da PUCRS e da Universidade do Algarve – Portugal. A maioria destes artigos era de revisão bibliográfica. Outra conclusão importante é que houve, a partir do início desta década, uma preocupação maior com o bem-estar docente do que propriamente com o mal-estar docente. Assim, é nosso desejo que este artigo possa promover futuras pesquisas nesta área, enfatizando o bem-estar dos professores, consolidando a tendência mundial das publicações sobre o tema

  18. Prescrições para tratamento de malária não complicada em gestantes na Amazônia Legal: evidências do Projeto Mafalda*

    Directory of Open Access Journals (Sweden)

    Tatiana Chama Borges Luz

    2013-06-01

    Full Text Available Objetivos: Avaliar prescrições de antimaláricos segundo indicadores de qualidade e descrever relatos de eventos adversos entre gestantes com malária não complicada. Métodos: Estudo descritivo de prontuários de gestantes maiores de 15 anos, residentes em municípios de alto risco na Amazônia Legal. Antimaláricos caracterizados segundo frequência de prescrição, tipo de plasmódio e de unidade de saúde de atendimento, e de possíveis eventos adversos. Para comparação das variáveis estudas utilizou-se o teste do qui-quadrado de Pearson. Resultados: Foram avaliados 262 prontuários de gestantes. A maioria das gestantes pesquisadas recebeu diagnóstico de infecção por P. vivax (71,2%. Cloroquina foi o fármaco mais prescrito (65,6%. Fármacos não recomendados foram encontrados em 9,0% e 16,2% das prescrições para P. vivax e P. falciparum , respectivamente. Prescrições para P. falciparum , em proporção significativamente maior, contiveram esquemas e posologia e/ou duração do tratamento não adequados ao protocolo oficial (p = 0,001, bem como sem especificação da posologia (p = 0,004. Não houve diferenças significativas entre hospitais de referência e unidades básicas de saúde quanto aos esquemas de tratamento, proporções de prescrições contendo esquemas de tratamento não adequados e sem especificação da posologia. Cloroquina foi o fármaco mais envolvido em ocorrências de eventos adversos. Conclusões: Os resultados mostraram deficiências na prescrição de antimaláricos para gestantes, especialmente quanto à adequação ao protocolo oficial.

  19. Mal-estar, sofrimento e sintoma: releitura da diagnóstica lacaniana a partir do perspectivismo animista Discontent, suffering and symptom: a Lacanian diagnostic re-reading via animist perspectivism

    Directory of Open Access Journals (Sweden)

    Christian Ingo Lenz Dunker

    2011-01-01

    Full Text Available O objetivo deste artigo é apresentar a noção de forma de vida como conceito útil para a recontextualização da diagnóstica psicanalítica, decorrente dos trabalhos de Jacques Lacan, no quadro da metadiagnóstica da modernidade, desenvolvida pelas teorias sociais, especialmente as de extração crítica. Para justificar a utilidade clínica e crítica do conceito de forma de vida vamos realizar uma redescrição das oposições fundamentais da diagnóstica psicanalítica (falta e excesso, produção e improdução, determinação e indeterminação, consideradas, respectivamente, como derivativos da esfera do desejo, da linguagem e do trabalho. Para tanto, propomos uma homologia entre a psicopatologia psicanalítica e a noção de perspectivismo ameríndio, desenvolvida por Viveiros de Castro (2002, que adquire neste trabalho uma dupla finalidade: 1 responder a críticas dirigidas ao estruturalismo lacaniano em psicopatologia; e 2 justificar a distinção entre sintoma, sofrimento e mal-estar.The objective of this article is to explore the notion of life form as a useful concept for recontextualizing psychoanalytic diagnosis, as inspired by the works of Jacques Lacan, within the framework of the metadiagnosis of modernity developed by social theories, especially those of a critical inclination. To justify the clinical and critical utility of the concept of life form, the text embarks on a re-description of the fundamental oppositions of psychoanalytic diagnosis (lack and excess, production and non-production, determination and indetermination as derived from the spheres of desire, language and work respectively. This aim in mind, the text proposes a homology between psychoanalytic psychopathology and the notion of Amerindian perspectivism developed by Viveiros de Castro (2002, which assumes a double purpose in this work: (1 to respond to critiques of Lacanian structuralism in psychopathology; and (2 to justify the distinction between

  20. Photoelectric guided AGV based on MC9S12XS128MAL%基于MC9S12XS128MAL控制的光电导引式AGV

    Institute of Scientific and Technical Information of China (English)

    刘波; 汪宇辰; 梁伟健; 叶波; 周杰

    2013-01-01

    Aiming at the drawbacks that automatic guided vehicles (AGV) are bulky and expensive,a system based on Freescale micro processor Mc9S12XS128MAL was used to design the economic photoelectric guided AGV system with the sophisticated intelligent car racing of the Froescale cup and the cheep electric wheelchairs.Experimental study on the ultrosonic sensors was carried out on a test rig.The obastacle distance in emergency was measured experimentally.The LCD module was introduced to display the real time velocity with using photoelectric encoders.Two brushless DC motors were used to drive the wheels,the deviation accumulated algorithm was proposed,The function was realized that the brushless DC motors successfully drive the AGV forward and to turn through differential control.At last,the control method was validated in the experiment.The results indicate that the AGV system is of quick dynamic response and stable operation,and the automatic control of the AGV is excellently realized.%针对目前国内自动导引运输车(AGV)体积大、价格贵的问题,在技术成熟的“飞思卡尔”智能汽车竞赛和价格低廉的电动轮椅车的基础上,设计了一款基于“飞思卡尔”MC9S12XS128MAL微处理器控制的经济型光电导引式AGV系统.在试验台上对超声波传感器进行了测试,确定了紧急情况下的避障距离;采用光电码盘测速,由液晶模块显示出AGV的实时速度;同时结合无刷直流电机驱动原理,提出了基于偏差累积算法的控制方法,实现了差动方式的无刷直流电机驱动AGV直线行驶和转弯的功能,最后通过实验验证了该控制方法的有效性.研究结果表明,此AGV系统响应迅速、运行稳定,很好地实现了AGV的自动控制.

  1. Quantification of Internal Stress-Strain Fields in Human Tendon: Unraveling the Mechanisms that Underlie Regional Tendon Adaptations and Mal-Adaptations to Mechanical Loading and the Effectiveness of Therapeutic Eccentric Exercise

    Science.gov (United States)

    Maganaris, Constantinos N.; Chatzistergos, Panagiotis; Reeves, Neil D.; Narici, Marco V.

    2017-01-01

    of the stress created by the exercise and is not only reliant upon the type of muscle contraction performed. To better understand the micromechanical behavior and regional adaptability/mal-adaptability of tendon tissue it is important to estimate its internal stress-strain fields. Recent relevant advancements in numerical techniques related to tendon loading are discussed. PMID:28293194

  2. The MAL: A Malware Analysis Lexicon

    Science.gov (United States)

    2013-02-01

    grandfather, James Murray, and his heroic, Victorian project to build the first edition of the Oxford English Dictionary. He recruited a network of...code to ensure that the binaries in question have not been altered. binary registry pattern matching The practice of searching the binary of an...artifact for particular patterns indicative of certain properties.6 bit flipping A technique used in fuzzers that randomly inverts a single bit in

  3. Case 1432: MAL 8(1)

    DEFF Research Database (Denmark)

    Lookofsky, Joseph

    2014-01-01

    This publication reports a decision by the Supreme Court (Højesteret) of Denmark, 22 juni 2012 in case 210/2011 (1. afd.). Dregg v. Chr. Jensen Shipping. Published in Danish: Ugeskrift for Retsvæsen 2012 p. 3001 et seq. The decision relates to the U.N. Model Arbitration Law and the...

  4. Brasil: un arte popular mal comunicado

    Directory of Open Access Journals (Sweden)

    Dilma De Mela Silva

    2015-01-01

    Full Text Available En "Auge y caída de los vÍdeo juegos" el autor señala que las tecnologías digitales cambian aceleradamente. Cada cambio impacta en el entorno de la sociedad y la cultura ¿Cómo adaptarse a estos retos? ¿Cómo controlarlos? se responde en el artículo. Otro artículo hace alusión a la conmemoración de los 10 años de la Declaración del Nuevo Orden Internacional de la Información y Comunicación - NOIIC-. Radio boletín informativo para niños cita las recomendaciones dadas en el Seminario realizado por el CIESPAL, la O E A , Radio Nederland y la Fundación Friedrich E. y confirma la necesidad de que si se va a comunicar a los niños, es necesario capacitarse. Se analiza el decálogo del comunicador infantil, enfatizando en que los niños valen y exigen. "Avances psicológicos de la publicidad" es un resumen del libro de William Meyers "Los creadores de imagen" trata básicamente del poder de persuasión de Madison Avenue en sus campañas publicitarias y explica la cultura consumista en Estados Unidos, luego de la segunda guerra Mundial.

  5. Der Schmatzomat – Schokolade mal anders verpacken

    OpenAIRE

    Braun, Meike; Hochstein, Maximilian; Furmans, Kai

    2014-01-01

    Am Institut für Fördertechnik und Logistiksysteme (IFL) wurde zur Unterstützung und Entlastung der behinderten und nicht behinderten Mitarbeiter der Ostalb-Werkstätten der Samariterstiftung eine Apparatur zur Verpackung von Schokoladenriegeln entwickelt. Grundlage des „Schmatzomaten“ sind dabei rein mechanische Prinzipien, die den Durchsatz der verpackten Schokoladenriegel (des „Schmatz“) erhöhen, gleichzeitig aber auch zu einer Erleichterung des Gesamtprozess führen. At Institut für Förde...

  6. Fenomena Mal bagi Masyarakat Urban di Jakarta

    Directory of Open Access Journals (Sweden)

    Amarena Nediari

    2013-04-01

    Full Text Available Mall building is a place where urban communities come together with their specific interest. People go to the mall with their independent needs without any emotional bonding between each other. As a public space, mall is trying to meet the needs of urban communities especially as an entertaining space for the visitors. Go to the mall has become a way of life in urban society, as a destination for the whole family. While on the other hand the existence of many mall building are the traits of sick city, because as a public space, city does not meet the social and environmental objectives anymore. Jakarta has more than 75 building mall, it has exceeded the limit of the population. Mall has become a phenomenon because it has met the lifestyle of urban society but on the other side mall has spent water absorption area. This disagreement about mall building requires a mall that friendly to the environment, so that the green open spaces and water absorption area can be provided or replaced as well. The next discussion is about mall that should build friendly to the environment and its importance to the urban community. 

  7. Le mal et ses complots imaginaires

    OpenAIRE

    Frankfurter, David

    2012-01-01

    Les récits d’abus rituels sataniques que les médias ont largement diffusés, aux États-Unis et au Royaume-Uni, entre le début des années 1980 et la fin des années 1990, soutenaient le parallèle avec les allégations avancées, durant l’Antiquité et au début des Temps modernes, contre les chrétiens, les hérétiques, les juifs ou les sorcières. Quelle est la nature de ces parallèles ? Cet article examine plusieurs types de modèles convoqués lors de diverses occurrences historiques des peurs panique...

  8. Brasil: un arte popular mal comunicado

    OpenAIRE

    Dilma De Mela Silva

    2015-01-01

    En "Auge y caída de los vÍdeo juegos" el autor señala que las tecnologías digitales cambian aceleradamente. Cada cambio impacta en el entorno de la sociedad y la cultura ¿Cómo adaptarse a estos retos? ¿Cómo controlarlos? se responde en el artículo. Otro artículo hace alusión a la conmemoración de los 10 años de la Declaración del Nuevo Orden Internacional de la Información y Comunicación - NOIIC-. Radio boletín informativo para niños cita las recomendaciones dadas en el Seminario realizado po...

  9. Oxygen minimum seafloor ecological (mal) functioning

    Digital Repository Service at National Institute of Oceanography (India)

    Moodley, L.; Nigam, R.; Ingole, B.S.; PrakashBabu, C.; Panchang, R.; Nanajkar, M.; Sivadas, S.; van Breugel, P.; van Ijzerloo, L.; Rutgers, R.; Heip, C.H.R.; Soetaert, K.; Middelburg, J.J.

    OM transformation is hampered (“batteries not included”, Lane 2006) resulting in rapid/immediate OM transfer out of the fast- biological cycle into the “slow (geological)” carbon cycle. From a biogeochemical point of view, the question of what..., N., 2006. Batteries not included, what can’t bacteria do? Nature, 441, 274-277. Law, G.T.W., Shimmield, T.M., Shimmield, G.B., Cowie, G.L. Breuer, E.R., Harvey, S.M., 2009. Manganese, iron, and sulphur cycling on the Pakistan margin. Deep Sea...

  10. PENGARUH KEBUDAYAAN KONTEMPORER DALAM PERANCANGAN ARSITEKTUR MAL

    OpenAIRE

    Freddy H. Istanto

    2000-01-01

    Market is traditionally known as the place where the seller and the buyers meet. In its development, it grows to be big shopping centers and even malls. Along with it, the concept of market has also changed within this building. It is not only the place where the transaction between the sellers and the buyers happen but also it expands to be the one where each person has turned to be the "player" in the nowadays "cultural-theatre". Being the designers, the architect is challenged to respond t...

  11. Réaction du polyisobutène chloré sur l'anhydride maléique : mécanisme. Catalyse par l'anhydride dichloromaléique Reaction of Chlorinated Polyisobutene on Maleic Anhydride. Mechanism. Catalysis by Dichloromaleic Anhydride

    Directory of Open Access Journals (Sweden)

    Sillion B.

    2006-11-01

    Full Text Available Dans cet article le mécanisme de la réaction de condensation du polyisobutène chloré sur l'anhydride maléique, qui sert dans la synthèse d'additif pour lubrifiant, est étudié par une cinétique globale et par un travail sur composés modèles. Il est montré que, dans cette réaction, l'anhydride maléique joue un double rôle : de catalyseur de déshydrochloration par une réactivité de type acide de Lewis organique, de réactif comme diénophile. Grâce à ces résultats, il est proposé une catalyse par l'anhydride dichloromaléique, qui permet une amélioration sensible du procédé. This article examines the mechanism of the chlorinated-polyisobutene condensation reaction on maleic anhydride. The overall kinetics and model compounds are investigated for this reaction which is used in the synthesis of lubricant additives. Maleic anhydride is shown to play the dual role of a dehydrochlorination catalyst by having a reactivity of the organic Lewis acid type and of a reactant like dienophile. These results are used to propose a catalysis by dichloromaleic anhydride which appreciably improves the process.

  12. Doença de alzheimer e demandas de cuidados: o que os enfermeiros sabem? Mal de Alzheimer y demandas de cuidados: ¿Cuánto saben los enfermeros? Alzheimer diseases and care demands: what do nurses know?

    Directory of Open Access Journals (Sweden)

    Silvana Poltroniere

    2011-06-01

    Full Text Available O objetivo deste estudo foi desvelar o conhecimento de enfermeiros de unidades de internação clínica acerca da Doença de Alzheimer (DA e da demanda de cuidados de pacientes e familiares. Estudo descritivo-exploratório, com abordagem qualitativa. Os dados foram obtidos através de entrevista semi-estruturada. A saturação dos dados ocorreu com 11 enfermeiros de dois hospitais privados. Da análise de conteúdo, emergiram seis categorias: caracterização da DA, fatores de risco, formas de diagnóstico, complicações, medicações para tratamento, cuidados com doente e família. Observou-se que os enfermeiros possuem um conhecimento limitado sobre a DA, focando as ações de cuidado na alteração clínica que motivou a internação hospitalar. Reconhecem sinais e sintomas, mas se mostram como figuras coadjuvantes na assistência, quando deveriam posicionar-se de forma mais autônoma frente ao cuidado e à atenção à família.El objetivo de este estudio fue revelar el conocimiento de enfermeros de unidades de internación clínica sobre la Enfermedad o Mal de Alzheimer (EA y las exigencias del cuidado de los pacientes y sus familias. Estudio descriptivo exploratorio, con abordaje cualitativo. Los datos fueron obtenidos a través de entrevista semiestructurada. La saturación de datos se realizó con once enfermeros de dos hospitales privados. Del análisis de contenido, emergieron seis categorías: caracterización de la EA, factores de riesgo, formas de diagnóstico, complicaciones, medicación para tratamiento, cuidados con el enfermo y la familia. Se observó que los enfermeros poseen un conocimiento parcial sobre la EA, enfocando las acciones de cuidado en la alteración clínica que causó la internación hospitalaria. Reconocen señales y síntomas, pero se muestran figuras coadyuvantes en la asistencia, cuando deberían posicionarse de forma más autónoma frente al cuidado y a la atención a la familia.The aim of the present study

  13. Posição viciosa de cabeça por astigmatismo mal corrigido: relato de caso Abnormal head position caused by incorrect prescription for astigmatism: case report

    Directory of Open Access Journals (Sweden)

    Flávia Augusta Attié de Castro

    2005-10-01

    Full Text Available A posição viciosa de cabeça é uma condição compensatória que visa proporcionar aos pacientes melhor rendimento visual. Pode ser causada por problemas oftalmológicos, como distúrbios oculomotores (nistagmos, estrabismos e altos astigmatismos. No entanto, compromete a estética e, a longo prazo, pode causar transtornos ortopédicos (coluna cervical e assimetrias faciais. Relatamos o caso de uma garota, JL, 8 anos, com cabeça inclinada para esquerda havia vários anos. Fazia uso de óculos prescritos em outro serviço para correção de astigmatismo misto: OD= +2,00 DE Ç -5,50 DC a 180º e OE= +2,25 DE Ç -5,75 DC a 180º. No exame oftálmico, a paciente apresentava cabeça inclinada para a esquerda e acuidade visual com correção de 0,5 no OD e 0,7 OE. Os testes de cobertura simples e alternado não evidenciaram desvio ocular. Rotações oculares, biomicroscopia e fundoscopia também não mostraram alterações. Na refratometria sob cicloplegia e teste de lentes foram encontrados: OD= +3,50 DE Ç -6,00 DC a 10º e OE= +3,50 DE Ç -6,00 DC a 170º, com acuidade visual igual a 1,0 nos olhos direito e esquerdo. Foram prescritas as lentes encontradas no exame e a paciente retornou com a correção nova sem a inclinação de cabeça. Erros refracionais mal corrigidos também podem gerar torcicolo e, muitas vezes, passam despercebidos. Refratometria sob cicloplegia e teste de lentes são fundamentais para um diagnóstico preciso.Abnormal head position is a compensatory condition which improves patients' vision. It can be caused by ophthalmological problems such as oculomotor imbalances (strabismus, nystagmus and high astigmatisms. However, it results in esthetic impairment, orthopedic trouble and facial asymmetries. We describe a case of a girl, JL, 8 years, with abnormal head position tilted to the left since the last glasses were prescribed. The correction used by the patient was: right eye = +2.00 sph à -5.5 cyl 180° and left eye = +2

  14. Salivary gland proteins of the human malaria vector, Anopheles dirus B (Diptera: Culicidae Proteínas das glândulas salivares do Anopheles dirus B (Diptera: Culicidae, vetor da malária humana

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    Narissara Jariyapan

    2007-02-01

    Full Text Available Salivary gland proteins of the human malaria vector, Anopheles dirus B were determined and analyzed. The amount of salivary gland proteins in mosquitoes aged between 3 - 10 days was approximately 1.08 ± 0.04 µg/female and 0.1 ± 0.05 µg/male. The salivary glands of both sexes displayed the same morphological organization as that of other anopheline mosquitoes. In females, apyrase accumulated in the distal regions, whereas alpha-glucosidase was found in the proximal region of the lateral lobes. This differential distribution of the analyzed enzymes reflects specialization of different regions for sugar and blood feeding. SDS-PAGE analysis revealed that at least seven major proteins were found in the female salivary glands, of which each morphological region contained different major proteins. Similar electrophoretic protein profiles were detected comparing unfed and blood-fed mosquitoes, suggesting that there is no specific protein induced by blood. Two-dimensional polyacrylamide gel analysis showed the most abundant salivary gland protein, with a molecular mass of approximately 35 kilodaltons and an isoelectric point of approximately 4.0. These results provide basic information that would lead to further study on the role of salivary proteins of An. dirus B in disease transmission and hematophagy.Proteínas das glândulas salivares do Anopheles dirus B (Diptera: Culicidae, vetor da malária humana foram determinadas e analisadas. A quantidade de proteínas das glândulas salivares em mosquitos com três a 10 dias de idade foi de aproximadamente 1,08 ± 0,04 µg/ fêmea e de 0,1 ± 0,05 µg/macho. As glândulas salivares de ambos os sexos mostraram organização morfológica semelhante à de outros mosquitos anofelinos. Em fêmeas, apirase acumula-se nas regiões distais, enquanto alfa-glucosidase foi encontrada na região proximal dos lóbulos laterais. Esta distribuição diferencial das enzimas analisadas reflete a especialização de

  15. EL MALESTAR EN LA RELACIÓN MÉDICO- PACIENTE O MAL ESTAR NA RELAÇÃO MÉDICO-PACIENTE UNEASINESS IN THE PHYSICIAN-PATIENT RELATIONSHIP

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    Gabriela Manitta

    2005-01-01

    Full Text Available Lo que se plantea en torno al malestar en la relación médico- paciente es la posibilidad de reconocer la locura que engendran algunas normas, tales como aquella que pretende transformar la acción médica en una operación de autómata. El médico puede asumir una posición diferente si está dispuesto a preservar en sí el lugar de su propia ignorancia acerca de la particularidad inalienable de cada enfermo, de esa historia individual en la que anida el síntoma. Pues aun cuando se esté en condiciones de afirmar que se han respetado los derechos del paciente, nada se sabe de él. Es necesario que el médico pueda situarse frente al sujeto como frente a un misterio para poder reconocer la particularidad de éste y para que el paciente pueda reconocerse en su particularidadO que se coloca em torno do mal estar na relação médico-pacinte é a possibilidde de reconhecer a loucura provocada por algumas normas, tais como aquela que pretende transformar a ação médico numa operação autômata. O médico pode assumir uma posição diferente se está disposto a preservar em si, o lugar de sua própria ignorância em relação à singularidade inalienável de cada doente, de sua história individual que se localiza no sintoma. Mesmo quando se está em condições de afirmar que os direitos do paciente foram respeitados, nada se sabe dele. É necessário que o médico se situe frente ao sujeito, estando frente a um mistério para poder reconhecer a singularidade deste, e para que o paciente também possa reconhecer-se em sua singularidadeThe possibility to recognize the madness that certain norms generate, such as the one that pretends to transform the medical action into an automaton's operation is stated around the uneasiness in the physician-patient relationship. Physicians may assume a different position if they are willing to keep in themselves the sight of their own ignorance about the inalienable particularity of each sick person, and of

  16. Cistatina C como predictor de síndrome cardio-renal y mal pronóstico en pacientes internados por insuficiencia cardíaca aguda y función renal normal

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    Iván Constantin

    2016-01-01

    Full Text Available Introducción: El desarrollo de disfunción renal en el contexto de una falla cardíaca aguda se conoce como síndrome cardiorrenal (SCR tipo 1. El empeoramiento de la función renal (EFR durante la internación es un predictor de mal pronóstico. La cistatina C ha surgido como un marcador de función renal alternativo a la creatinina. Objetivo: Demostrar la utilidad clínica de la cistatina C como predictor de EFR y factor pronóstico en pacientes con insuficiencia cardíaca aguda y sin disfunción renal evaluada por creatinina al ingreso. Material y métodos: Se llevó a cabo un estudio observacional, prospectivo, de pacientes consecutivos con diagnóstico de insuficiencia cardíaca aguda y sin disfunción renal, definida como un valor de creatinina < 1,3 mg/dl al ingreso. Se realizó un dosaje de cistatina C al ingreso. El punto final primario fue EFR y los secundarios fueron mortalidad hospitalaria, mortalidad total y reinternación por insuficiencia cardíaca. Resultados: Se incluyeron 166 pacientes con una mediana de edad de 85 años (IIC 77,7-89. La incidencia de EFR fue del 29,7%, con una mortalidad hospitalaria del 3,1% y una mortalidad total del 24,4%. La mediana de seguimiento fue de 193 días. El valor de cistatina C fue significativamente mayor en los pacientes que desarrollaron EFR (1,72 ± 0,58 mg/dl vs. 1,51 ± 0,41 mg/dl; p = 0,03 y en los pacientes que murieron en el seguimiento (1,76 ± 0,49 mg/dl vs. 1,51 ± 0,46 mg/dl; p = 0,004. La cistatina C resultó un predictor independiente de mortalidad (OR 3,03, IC 95% 1,22-7,47 y de EFR (OR 2,38, IC 95% 1,02- 5,5 en el análisis multivariado. Se halló un punto de corte óptimo de 1,6 mg/dl de cistatina, con una sensibilidad del 61,22% y una especificidad del 60,34% para el desarrollo de EFR y del 61,54% y 61,98%, respectivamente, para mortalidad total. Conclusión: El valor de cistatina C al ingreso es predictor de desarrollo de EFR durante la internación y de mayor mortalidad en

  17. Factores que determinan el mal pronóstico y la exacerbación del asma en niños que asisten a consulta de alergología pediátrica Factors determining the poor prognosis and asthma exacerbation in children seen in the pediatric allergy service

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    Alain R. Rodríguez-Orozco

    2007-03-01

    Full Text Available El asma es una de las enfermedades de mayor impacto en la práctica pediátrica. Este es un estudio descriptivo, transversal que se realizó con el objetivo de identificar los factores que determinan la exacerbación y el mal pronóstico del asma bronquial en los niños. Se estudiaron 45 pacientes con diagnóstico de asma bronquial. Las crisis se presentaron en el hogar en el 76 % y en el 24 %, en la escuela. Los desencadenantes de las crisis agudas de asma bronquial fueron: el ejercicio (73 %, las infecciones respiratorias (57 % y la rinitis (55 %. Los factores de mal pronóstico más frecuentemente encontrados fueron: rinorrea sin catarro (60 %, sexo masculino (51 %, 3 o más episodios de sibilancias en los 6 meses previos (42 % y asma en los padres (37 %. La presencia de las exacerbaciones y los criterios de mal pronóstico repercuten en el control y en la calidad de vida del niño asmático y deben detectarse en la consulta de atención primaria.Asthma is one of the diseases with a greater impact on pediatric practice. This descriptive, cross-sectional study was undertaken to identify those factors determining the exacerbation and poor prognosis of bronchial asthma in children. Forty five patients with diagnosis of bronchial asthma were studied. The crises were developed at home in 76 % and at school in 24 % of the children. Triggering causes of acute crises of bronchial asthma were: exercise (73 %, respiratory infections (57 %, and rhinitis (55 %. The factors of poor prognosis most frequently found were: rhinorrhea without cold (60 %, male sex (51%, three or more episodes of wheezes in previous months (42 %, and asthma in parents (37 %. The presence of exacerbations and the criteria of poor prognosis influence on the control and quality of life of the asthmatic children, and they should be detected at the primary care level.

  18. Controle da transmissão da malária em área de garimpo no Estado do Amapá com participação da iniciativa privada Control of malaria transmission in a gold-mining area in Amapá State, Brazil, with participation by private enterprise

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    Álvaro Augusto Couto

    2001-08-01

    Full Text Available Reportamos no presente trabalho a caracterização epidemiológica da malária, seguida da implantação de um programa de controle da endemia em uma área de garimpo, localizada ao norte do estado do Amapá. Considera-se a influência desta região no número total de casos do estado e o impacto da doença na população representada pelos funcionários e empreiteiros da Mineração Novo Astro S/A, bem como pela comunidade da Vila de Lourenço, Município de Calçoene, Amapá e garimpos adjacentes. O impacto das ações de controle adotadas no âmbito do programa, caracterizam-se pela significativa redução da incidência da malária na área e a redução da morbi-mortalidade. Ressalta-se a importância da participação da iniciativa privada, principalmente aquelas que desenvolvem projetos de grande porte na região Amazônica brasileira, no controle das endemias prevalentes na região, particularmente a malária.This paper reports on the epidemiological characterization of malaria following implementation of a program to control the endemic in a gold-mining area in northern Amapá State. The study focuses on total malaria cases in Amapá and the impact of the disease on the population, as represented by the Mineração Novo Astro S/A company and its employees as well as the community of Vila de Lourenço in the municipality of Calçoene, and adjacent gold miners. The effect of control measures in the program area is indicated by a significant reduction in malaria incidence and malaria-related morbidity and mortality. The importance of participation by private enterprise is emphasized, particularly in large projects for the control of endemic diseases (notably malaria in the Amazon Region.

  19. Retrospective study of malaria prevalence and Anopheles genus in the area of influence of the binational Itaipu reservoir Estudo retrospectivo da prevalência de malária e do gênero Anopheles na área de influência do reservatório de Itaipu Binacional

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    Ana Lucia Falavigna-Guilherme

    2005-04-01

    Full Text Available The importance of hydroelectric dams beside the human interchange in the maintenance of malarious foci and the occurrence of the Anopheles genus on the Binational Itaipu Reservoir were the main points of this retrospective study. Data were collected from existing registrations at National, State and Municipal Health Departments and literature systematic overview, from January 1984 to December 2003. The occurrence of some outbreak of malaria, mainly by Plasmodium vivax, and the prevalence of species of the Anopheles genus different from Anopheles darlingi in the region are discussed. The malaria in the left bank of Paraná River is a focal problem, which must be approached locally through health, educational and social actions to prevent the continuity of outbreaks in the area. Concomitantly, it is necessary to plan and apply effective surveillance measures in the influence area of the Itaipu Reservoir.A importância de reservatórios de hidroelétricas e do intercâmbio humano na manutenção de focos de malária e a ocorrência do gênero Anopheles no reservatório de Itaipu Binacional foram os pontos destacados neste estudo retrospectivo. Os dados foram coletados de registros existentes em órgãos municipais, estadual e nacional de saúde e por revisão sistemática da literatura, no período de janeiro de 1984 a dezembro de 2003. A ocorrência de alguns surtos de malária, principalmente por Plasmodium vivax, e a prevalência de espécies do gênero Anopheles diferentes de Anopheles darlingi na região foram discutidos. A malária na margem esquerda do rio Paraná é um problema focal que deve ser abordado localmente através de medidas voltadas à saúde, educação e área social que previnam a continuidade da ocorrência de surtos na área. Concomitantemente, é necessário planejar e aplicar medidas efetivas de vigilância epidemiológica na área de influência do reservatório de Itaipu.

  20. Efficacy of sulfadoxine-pyrimethamine and mefloquine for the treatment of uncomplicated Plasmodium falciparum malaria in the Amazon basin of Peru Eficácia da sulfadoxina-pirimetamina e mefloquina no tratamento de malária não-complicada por Plasmodium falciparum na bacia amazônica peruana

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    Alan J. Magill

    2004-06-01

    Full Text Available In vivo antimalarial drug efficacy studies of uncomplicated Plasmodium falciparum malaria at an isolated site in the Amazon basin of Peru bordering Brazil and Colombia showed >50% RII/RIII resistance to sulfadoxine-pyrimethamine but no evidence of resistance to mefloquine.Testes in vivo foram realizados para avaliar resistência a drogas antimalária, em pessoas com malária não complicada, causada por Plasmodium falciparum, numa região isolada da Bacia Amazônica, na fronteira com o Brasil e a Colômbia. Os testes mostraram resistência >50% RII/RIII a sulfadoxina-pirimetamina, mas não evidenciaram resistência a mefloquina.

  1. A utilização de uma rede neural artificial para previsão da incidência da malária no município de Cantá, estado de Roraima Use of an artificial neural network to predict the incidence of malaria in the city of Cantá, state of Roraima

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    Guilherme Bernardino da Cunha

    2010-10-01

    Full Text Available INTRODUÇÃO: A malária é uma doença endêmica na Amazônia Legal Brasileira, apresentando riscos diferentes para cada região. O Município de Cantá, no Estado de Roraima, apresentou para todo o período estudado, um dos maiores índices parasitários anuais do Brasil, com valor sempre maior que 50. O presente estudo visa à utilização de uma rede neural artificial para previsão da incidência da malária nesse município, a fim de auxiliar os coordenadores de saúde no planejamento e gestão dos recursos. MÉTODOS: Os dados foram coletados no site do Ministério da Saúde, SIVEP - Malária entre 2003 e 2009. Estruturou-se uma rede neural artificial com três neurônios na camada de entrada, duas camadas intermediárias e uma camada de saída com um neurônio. A função de ativação foi à sigmoide. No treinamento, utilizou-se o método backpropagation, com taxa de aprendizado de 0,05 e momentum 0,01. O critério de parada foi atingir 20.000 ciclos ou uma meta de 0,001. Os dados de 2003 a 2008 foram utilizados para treinamento e validação. Comparam-se os resultados com os de um modelo de regressão logística. RESULTADOS: Os resultados para todos os períodos previstos mostraram-se que as redes neurais artificiais obtiveram um menor erro quadrático médio e erro absoluto quando comparado com o modelo de regressão para o ano de 2009. CONCLUSÕES: A rede neural artificial se mostrou adequada para um sistema de previsão de malária no município estudado, determinando com pequenos erros absolutos os valores preditivos, quando comparados ao modelo de regressão logística e aos valores reais.INTRODUCTION: Malaria is endemic in the Brazilian Amazon region, with different risks for each region. The City of Cantá, State of Roraima, presented one of the largest annual parasite indices in Brazil for the entire study period, with a value always greater than 50. The present study aimed to use an artificial neural network to predict the

  2. Biologia de anofelinos amazônicos: XII. Ocorrência de espécies de Anopheles, dinâmica da transmissão e controle da malária na zona urbana de Ariquemes (Rondônia)

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    Tadei, Wanderli Pedro; Santos, Joselita Maria Mendes dos; Costa, Wellington Luciano de Souza; Scarpassa, Vera Margarete

    1988-01-01

    Dados sobre o grau de incidência e distribuição de espécies Anopheles, em Ariquemes (RO), evidenciaram que a diversidade é maior na periferia da cidade e que Anopheles darlingi é registrada em praticamente todas as localidades de coleta. O inquérito entomológico revelou níveis diferentes de penetração da espécie na área urbana, podendo-se constatar que os Setores 1 e 3 são áreas livres de malária; Setores 2 e 4 mostram riscos na periferia; e a Área Industrial e Setor de Áreas Especiais, Conju...

  3. Caracterização das epidemias de malária nos municípios da Amazônia Brasileira em 2010 Caracterización de las epidemias de malaria en los municipios de la Amazonia brasileña en 2010 Characteristics of malaria epidemics in the municipalities of the Brazilian Amazon, 2010

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    Pedro Luiz Tauil

    2013-05-01

    Full Text Available Epidemias de malária ocorrem anualmente nos municípios da Região Amazônica, Brasil, no entanto os serviços de saúde não adotam, de maneira sistemática, instrumentos para detecção e contenção oportunas desses eventos. O objetivo foi caracterizar as epidemias de malária na região segundo duração, espécie de Plasmodium e vulnerabilidade das populações. Foi avaliado um sistema de monitoramento automatizado da incidência da malária, com base no diagrama de controle segundo quartis, para identificar as epidemias da doença. Em 2010, ocorreram epidemias em 338 (41,9% municípios da região. Houve epidemias por P. falciparum e por P. vivax, separadamente, e também por ambas as espécies. Epidemias com duração de um a quatro meses ocorreram em 58,3% dos municípios epidêmicos; de cinco a oito meses, em 24,3%; e de nove a 12 meses, em 17,4%. O monitoramento automatizado da variação da incidência da malária poderá contribuir para detecção precoce das epidemias e melhorar o seu controle oportuno.Las epidemias de malaria ocurren anualmente en los municipios de la Región Amazónica, Brasil, no obstante, los servicios de salud no adoptan de manera sistemática instrumentos para la detección y contención oportuna de este tipo de eventos. El objetivo fue caracterizar las epidemias de malaria en la región según su duración, especie de Plasmodium y vulnerabilidad de las poblaciones. Se evalúo un sistema de supervisión automatizado de la incidencia de la malaria, en base al diagrama de control según cuartiles, con el fin de identificar las epidemias de la enfermedad. En 2010, se produjeron epidemias en 338 (41,9% municipios de la región. Hubo epidemias por P. falciparum y por P. vivax, separadamente, y también por ambas especies. Hubo epidemias con una duración de uno a cuatro meses que se produjeron en un 58,3% de los municipios epidémicos; de cinco a ocho meses, en un 24,3%; y de nueve a 12 meses, en un 17,4%. La

  4. Malaria epidemics in Europe after the First World War: the early stages of an international approach to the control of the disease Malária epidêmica na Europa após a Primeira Guerra Mundial: estágios iniciais de uma abordagem internacional de controle da doença

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    Gabriel Gachelin

    2011-06-01

    Full Text Available The severity and endemicity of malaria declined gradually in Europe until WWI. During and after the war, the number of malaria cases increased substantially and peaked in 1922-1924. This prompted the Hygiene Commission of the League of Nations to establish a Malaria Commission in 1923 to define the most efficient anti-malaria procedures. Additionally, between 1924 and 1930 there were several international meetings and collaborations concerning malaria, which involved the main institutes of parasitology and the Rockefeller Foundation. The Commission reports, the guidelines for anti-malaria campaigns and the scientific programs which came out of these meetings and collaborations are analyzed in the present paper.Antes da Segunda Guerra Mundial, a severidade e endemicidade da malária diminuíram gradualmente na Europa. Durante e após a guerra, o número de casos cresceu substancialmente, chegando ao máximo entre 1922 e 1924. Isso fez com que a Comissão de Higiene da Liga das Nações estabelecesse, em 1923, a Comissão de Malária, para definir procedimentos mais eficazes contra a doença. Entre 1924 e 1930 encontros e colaborações internacionais, nos quais estiveram envolvidos os principais intitutos de parasitologia e a Fundação Rockefeller, discutiram a enfermidade. Os relatórios da Comissão, as diretrizes para campanhas antimaláricas e os programas científicos decorrentes desses encontros e colaborações são analisados no artigo.

  5. THE SAFETY MEASURE OF PROHIBITING TO EXERCISE A PROFESSION, IMPOSED BY THE COURT IN CASE OF MAL PRAXIS, MAY ENVISAGE THE PROFESSION OF DOCTOR IN THE WIDER SENSE (AS A WHOLE OR ONLY THE SPECIALTY THAT OCCASIONED THE COMMITTING OF THE OFFENCE PROVIDED IN THE CRIMINAL LAW

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    Traian DIMA

    2018-05-01

    Full Text Available The present paper examines the possibility for the courts of law to order, in case of medical malpractice, the safety measure of prohibiting to exercise the profession of doctor in the wider sense, or only the specialty that occasioned the committing of the offence provided in the criminal law, analyzing the judicial practice regarding this issue. In accordance with Article 450 paragraph (2 of Law no. 95/2006, “disciplinary liability of doctors does not exclude criminal, tort or civil liability”. Between the regulation contained in Article 450 paragraph (2 of Law no. 95/2006 and the safety measure of prohibiting to exercise the profession of doctor, as criminal penalty, there is a close connection, within the meaning that the special law, in particular Law no. 95/2006 derogates from the general criminal law, in particular Article 111 of the Criminal Code in connection with the prohibition of exercising the medical profession. The disciplinary penalties that may be imposed against doctors for mal praxis are listed in Article 455 of Law no. 95/2006. Article 455 letter (e sets out, as disciplinary penalty which may be imposed against doctors “the prohibition to exercise the profession or certain medical activities” for a period ranging between one month and one year. Comparing the provisions of Article 455 letter (e of Law no. 95/2006 with the provisions of Article 111 of the Criminal Code, it may be noticed that the scope of disciplinary accountability of the doctor having committed the civil mal praxis is more comprehensive than the scope of the safety measure imposed by the criminal court.

  6. Le Mal africain – pas si mal que ça !

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    Mike Singleton

    2011-02-01

    Full Text Available De l’avis engagé d’une génération précédente d’observateurs occidentaux, aussi bien leurs propres couches populaires que la plupart des peuples primitifs se sont laissé faire par le rouleau compresseur de la Modernité. En Angleterre, où un surplus de fumier chevalin avait “libéré” pour le marché de l’emploi une main-d’œuvre paysanne aussi dépaysée que pléthorique (Wrigley, 1988, les Luddites (Thompson, 1968, dignes descendants d’autres défenseurs des causes perdues du Royaume comme les «Dig...

  7. Malária e aspectos hematológicos em moradores da área de influência dos futuros reservatórios das hidrelétricas de Santo Antônio e Jirau, Rondônia, Brasil Malaria and hematological aspects among residents to be impacted by reservoirs for the Santo Antônio and Jirau Hydroelectric Power Stations, Rondônia State, Brazil

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    Tony Hiroshi Katsuragawa

    2009-07-01

    Full Text Available Em Rondônia, prevê-se a construção de mais duas usinas hidrelétricas (UHE no rio Madeira, a montante da cidade de Porto Velho, Rondônia, Brasil (de Santo Antônio e Jirau. O objetivo deste trabalho foi analisar a prevalência da malária antes do início da implantação das obras civis e fazer considerações sobre os impactos da doença com o ingresso de milhares de trabalhadores e agregados atraídos pelas oportunidades de emprego e comércio. Os resultados obtidos mostram que a malária se faz presente em toda região, em variados graus de prevalência. Além disso, a existência de potenciais portadores assintomáticos de malária entre a população nativa pode ter relevância epidemiológica e deve ser considerada nos programas de controle da malária, vinda tanto das autoridades públicas quanto das empresas responsáveis pela instalação das UHE, visando o diagnóstico e tratamento precoce, controle vetorial, abastecimento de água e aplicação de infra-estrutura nos centros urbanos.In Rondônia State, Brazil, two new hydroelectric plants, Santo Antônio and Jirau, are scheduled for construction on the Madeira River, upriver from the State capital, Porto Velho. The current study analyzes malaria prevalence before the construction and provides information on the possible impacts of malaria burden related to the influx of thousands of persons attracted by direct and indirect employment opportunities. According to the findings, malaria is present throughout the region, with varying prevalence rates. The existence of potential asymptomatic malaria carriers among the local population may be epidemiologically relevant and should be considered in the malaria control programs organized by public authorities and companies responsible for building the power plants, aimed at early diagnosis and treatment, vector control, water supply, and infrastructure in the urban areas.

  8. Primary health care in municipalities at high risk for malaria Atención primaria a la salud en municipios de alto riesgo para malaria Atenção primária à saúde em municípios de alto risco para malária

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    Ana Cristina Soares Ferreira

    2011-12-01

    Programa Nacional de Control de Malaria y la Atención Básica de un modo general.Neste estudo pretendeu-se caracterizar aspectos da Atenção Básica, na região da Amazônia Legal, principal área endêmica para malária, no Brasil. O Ministério da Saúde recomenda a expansão da Atenção Básica nas áreas malarígenas. Foi realizado inquérito transversal, aplicado aos portadores de malária, em 6 municípios, durante os meses de janeiro e fevereiro de 2007. Os dados coletados foram tabulados e analisados, utilizando-se técnicas quantitativas. Registros de campo auxiliaram na composição das impressões do contexto dessas políticas nos locais pesquisados. A qualidade do acesso a consultas e medicamentos, o vínculo com os profissionais e com as Unidades Básicas de Saúde, o sistema de referência e contrarreferência, e a abordagem familiar e comunitária da saúde pelos profissionais, nos municípios do estudo, ainda são deficientes nesse nível de atenção. Há baixa integração entre o Programa Nacional de Controle de Malária e a Atenção Básica, de modo geral.

  9. Benign monomelic amyotrophy: a study of twenty-one cases Amiotrofia monomélica benigna: estudo de 21 casos

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    MARCOS R.G. DE FREITAS

    2000-09-01

    Full Text Available A consecutive series of 21 patients with single limb atrophy (monomelic amyotrophy is reported. Sixteen had lower limb atrophy and five had upper limb involvement. The median age of the onset was 20 years. Characteristic features were sporadic occurrence, wasting confined to one limb, insidious onset with slow progression, stabilizing in 1 to 4 years, and absence of pyramidal signs. All the patients with upper limb involvement were male, however in our cases with lower limb amyotrophy there were no male preponderance. We observed wasting of the entire length of the lower limbs in six patients. There were nine cases with amyotrophy restricted to the leg and one with amyotrophy only in the thigh. In the upper limb in four cases the involvement was distal and in one patient the atrophy was proximal. The electromyographic features were suggestive of anterior horn disease not only in the affected limb but also, in some cases, in clinically uninvolved limb. Cervical or lumbar MRI was normal. MRI of the lower limb disclosed increased signal intensity in the gastrocnemius and soleus muscles in one patient suggesting denervation.Relatamos uma série consecutiva de 21 pacientes com amiotrofia de um só membro, denominada de amiotrofia monomélica. Em 16 casos a atrofia era no membro inferior e em 5 localizava-se no membro superior. Todos eram jovens e a idade média do início foi 20 anos. Os dados mais característicos da doença foram ausência de história familiar, comprometimento de um só membro, início e progressão lenta estabilizando em até 4 anos e ausência de sinais piramidais. Nossos enfermos com amiotrofia de membro superior eram todos do sexo masculino, entretanto naqueles com amiotrofia do membro inferior havia igualdade de sexos. Dos pacientes com atrofia de membro inferior, em 9 a atrofia era restrita a perna, em 6 era em todo o membro e somente um apresentava amiotrofia localizada só na coxa. Naqueles com comprometimento do membro superior a atrofia era distal em 4 e proximal em 1. Os achados na eletromiografia foram compatíveis com acometimento do II neurônio motor. Todos foram submetidos a RM da coluna cervical ou lombar que se mostrou normal. Em um caso realizamos RM da perna acometida que evidenciou sinais hiperintensos nos músculos gastrocnemius e soleus, o que sugere desnervação.

  10. Estenosis esofágicas benignas: tratamiento con las bujías de Savary-Gilliard

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    Trini Fragoso Arbelo

    2001-09-01

    Full Text Available Se estudiaron 60 pacientes menores de 15 años con estenosis esofágica, 40 de ellos por ingestión de cáusticos y 20 por otras causas, susceptibles de tratamiento de dilatación endoscópica. Esta se realizó bajo anestesia general con un endoscopio GIF-XP10 de la casa Olympus y bajo pantalla fluoroscópica con las bujías de Savary-Gilliard modelo pediátrico. En las estenosis esofágicas secundarias a ingestión de cáustico se asoció al tratamiento inyectoterapia endoscópica con betametasona. El 66,6 % de la serie fue por ingestión de cáustico y en segundo lugar las ocurridas por causas posquirúrgicas, para el 20 %. El 70 % de las poscáusticos se clasificó según radiografía como severo. La localización más frecuente de las estenosis fue el tercio superior del esófago, con predominio de la variedad tubular en las debidas a cáusticos, y la anular en las otras causas. En las poscáusticos se realizaron 919 dilataciones en 288 sesiones, mientras que en las originadas por otras causas se efectuaron 223 en 67 sesiones. Como complicación se reportan 8 perforaciones, 1 sepsis y 3 seudodivertículos en el grupo de los cáusticos. No se observó mortalidad. El grupo secundario a cáustico necesitó mayor número de sesiones y de dilataciones promedio con respecto al otro grupo y con el 47,5 % de curación y el 95 % en las de otras causas. Se demostró que el método de dilataciones esofágicas de Savary-Gilliard es seguro, eficaz y con un mínimo de complicaciones.60 patients under 15 with esophageal stenosis, 40 of them due to caustic ingestion and 20 by other causes, susceptible to the treatment of endoscopic dilatation, were studied. It was performed with general anesthesia, using an Olympus GIF-XP10 endoscope and under fluoroscopic screen with Savary-Gilliard bougies, pediatric model. In the esophageal stenoses secondary to caustic ingestion, endoscopic betamethasone injection therapy was associated with the treatment. 66.6 % of the series were caused by caustic ingestion, whereas 20 % were due to postsurgical causes. 70 % of the postcaustic ingestion group were classsified as severe according to X-rays. The most frequent localization of stenosis was the upper third of the esophagus with predominance of the tubular variety among those caused by caustic ingestion and of the annulate variety in the other causes. In the postcaustic ingestion group, 919 dilatations were carried out in 288 sessions, whereas 223 were performed in 67 sessions in those originated by other causes. 8 perforations, 1 sepsis and 3 pseudodiverticula were reported as complications in the group that ingested caustics. There was no mortality. Those who ingested caustics needed a higher average number of sessions and dilatations than the other group. 47.5 % of them were cured in this group, whereas 95 % healed in the other group. It was proved that Savary-Gilliard method of esophageal dilatations is safe, efficient and has a minimum of complications.

  11. Mal posición de tornillos pediculares lumbares que producen radiculalgia mecánica postoperatoria con estimulación neurofisiológica intraoperatoria normal: el valor de la estimulación neurofisiológica del trayecto del tornillo

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    Vicente García González

    2013-12-01

    Full Text Available OBJETIVO: Valorar una exploración neurofisiológica que identifique estos casos intraoperatoriamente y evite la mal posición de tornillos pediculares. MÉTODOS: En 293 pacientes intervenidos de escoliosis por vía posterior con tornillos pediculares y técnica "free hand", se implantaron 6.739 tornillos. De estos, ocho pacientes (2,7%, con edad promedio de 24 años, presentaron dolor radicular lumbar postoperatorio. En la TC postoperatoria se encontraron 10 tornillos lumbares (2L1-3L2-4L3-1L4 con prominencia mínima en la parte inferior del pedículo. Se evaluaron los umbrales de EMG del tornillo y del trayecto. RESULTADOS: En cirugía inicial no se detectaron anomalías en la palpación del trayecto, ni en el control radioscópico, ni alteraciones neurofisiológicas en la estimulación neurofisiológica con t-EMG. Todos presentaron dolor radicular en bipedestación y sedestación que remitía con reposo en cama. Los tornillos fueron retirados quirúrgicamente a los 37 días en promedio (R:4-182. En esta cirugía se repitió la monitorización neurofisiológica y volvió a mostrar valores normales (> 11mA. Tras la retirada de los tornillos, se realizó estimulación del trayecto que mostró en la parte media, umbrales por debajo de los valores normales (3,9-10,7mA. Tras un seguimiento promedio de 4,4 años (R:2,6-6.8, cinco pacientes referían tener molestias radiculares ocasionales y uno tenía déficit motor mínimo en la extremidad afectada. CONCLUSIONES: Se presenta un tipo de mal posicionamiento de tornillo pedicular lumbar que produce radiculalgia en bipedestación-sedestación y que no es detectado con monitorización convencional. La estimulación neurofisiológica del trayecto en la zona media, tras retirada del tornillo pedicular, produjo umbrales bajos de estimulación. Se recomienda estimulación sistemática del trayecto antes de la inserción del tornillo pedicular lumbar.

  12. Resonancia magnética nuclear de encéfalo en pacientes con fenilcetonuria diagnosticada tardíamente

    OpenAIRE

    Jiménez-Pérez, Mario O.; Gómez-Garza, Gilberto; Ruiz-García, Matilde; Fernández-Lainez, Cynthia; Ibarra-González, Isabel; Vela-Amieva, Marcela

    2015-01-01

    Antecedentes: la fenilcetonuria clásica es una encefalopatía genética caracterizada por una inhabilidad de los individuos para metabolizar la fenilalanina, por lo que su concentración plasmática se eleva a niveles tóxicos. Clínicamente se manifiesta como irritabilidad, alteración del sueño, indiferencia al medio, crisis convulsivas, retraso del neurodesarrollo, conducta autista, agresividad y discapacidad intelectual. Objetivo: describir los hallazgos y cuantificar el coeficiente de difusión ...

  13. Resonancia magnética nuclear de encéfalo en pacientes con fenilcetonuria diagnosticada tardíamente

    OpenAIRE

    Mario O. Jiménez-Pérez; Gilberto Gómez-Garza; Matilde Ruiz-García; Cynthia Fernández-Lainez; Isabel Ibarra-González; Marcela Vela-Amieva

    2015-01-01

    Antecedentes: la fenilcetonuria clásica es una encefalopatía genética caracterizada por una inhabilidad de los individuos para metabolizar la fenilalanina, por lo que su concentración plasmática se eleva a niveles tóxicos. Clínicamente se manifiesta como irritabilidad, alteración del sueño, indiferencia al medio, crisis convulsivas, retraso del neurodesarrollo, conducta autista, agresividad y discapacidad intelectual. Objetivo: describir los hallazgos y cuantificar el coefic...

  14. Representaciones sociales de cáncer de cuello uterino en mujeres diagnosticadas acciones comunicativas con impacto cultural

    OpenAIRE

    Olarte Jaramillo, María del Rosario

    2017-01-01

    Tesis (Maestría en Educación y Desarrollo Humano). Universidad de Manizales. Facultad de Ciencias Sociales y Humanas. CINDE, 2016 A través de este ejercicio de investigación se accede a una revisión documental y tesis importantes alrededor de la salud y la enfermedad como objetos de estudio científicos multidisciplinares (antropología, medicina, comunicación, sociología, filosofía, etc.), ya que son experiencias reales de la existencia humana y no simples acontecimientos biológicos de cuer...

  15. Doenças de caprinos diagnosticadas na região Central no Rio Grande do Sul: 114 casos

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    Fábio B. Rosa

    2013-02-01

    Full Text Available Foi realizado um estudo retrospectivo dos arquivos do LPV-UFSM e examinados os laudos de necropsias de caprinos realizadas num período de 48 anos (1964 a 2011. Foram analisados 114 laudos de necropsias de caprinos. Deste total, 95 (83,33% tinham diagnóstico conclusivo e 19 (19,66% tinham diagnóstico inconclusivo. Dos 95 casos conclusivos, as doenças infecciosas e parasitárias foram as mais prevalentes, seguidas em ordem decrescente de prevalência, pelas doenças metabólicas e nutricionais, intoxicações e toxi-infecções e alterações do desenvolvimento. Outras alterações de diferentes naturezas e etiologias que não se enquadravam nos grupos de doenças acima afetaram cerca de 10% dos caprinos examinados. A hemoncose foi a principal causa de morte de caprinos na área de abrangência do LPV-UFSM. Eimeriose e listeriose também foram causas importantes de morte. Dentre as doenças metabólicas e nutricionais, urolitíase, osteoporose, toxemia da prenhez, desnutrição e doença dos músculos brancos foram as mais prevalentes. Principalmente as doenças infecciosas e parasitárias e as metabólicas e nutricionais ocorreram muitas vezes na forma de surtos, acarretando maiores perdas econômicas associadas.

  16. Alteraciones genéticas cutáneas diagnosticadas en la infancia, Las Tunas 2010-2012

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    Yordania Velázquez Ávila

    2014-08-01

    Full Text Available Las enfermedades genéticas y los defectos genéticos con afectación cutánea son causa frecuente de estigmatización de las personas que las padecen, afectando su adecuada inserción en la sociedad y con ello su calidad de vida. Se estableció una consulta especializada y multidisplinaria en el hospital pediátrico provincial “Mártires de Las Tunas”, fundamentalmente con especialistas de dermatología, genética y pediatría. Se realizó un estudio descriptivo, transversal y prospectivo, en el período del año 2010 al 2012, para caracterizar a estos pacientes. Las variables estudiadas relacionadas fueron el sexo, la edad biológica al diagnóstico, el municipio de procedencia y la mortalidad. Los resultados se expusieron en tablas de contingencia de N x N. Existió predominio de las genodermatosis, seguido de los defectos congénitos y pocas enfermedades genéticas con afectación cutánea, siendo estas últimas responsables de la mayoría de las muertes. Las genodermatosis más representadas fueron la ictiosis, las mastocitosis y las neurofibromatosis, la edad más frecuente al diagnóstico fue el grupo de los menores de dos años; prevaleció el sexo femenino. La mortalidad fue baja y los municipios más afectados por genodermatosis fueron Las Tunas, Majibacoa y Colombia

  17. Hemoglobin Kansas found by electrophoretic diagnosis in Brazil Hemoglobina Kansas diagnosticada através de eletroforese no Brasil

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    Claudia R. Bonini-Domingos

    2002-03-01

    Full Text Available Some hemoglobin variants with abnormal oxygen affinity have been reported so far from various regions of the world. They can be classified by their oxygen affinity and 15 variants with low oxygen affinity have been reported. A number of hemoglobin mutants which show an abnormal affinity for oxygen have been reported, but only few cases of hemoglobin Kansas. All cases reported so far are from Japan or in Japanese families. In this paper we describe a Brazilian patient with cyanosis and hemoglobin Kansas diagnosed by an electrophoretical procedure.Hemoglobinas variantes com afinidade anormal ao oxigênio têm sido encontradas em várias partes do mundo. Pela sua afinidade ao oxigênio, estas hemoglobinas variantes têm sido classificadas e 15 variantes com baixa afinidade relatadas. Numerosas hemoglobinas mutantes com afinidade anormal têm também sido relatadas, mas somente poucos casos de Hemoglobina Kansas. Os casos são de pacientes procedentes do Japão, ou de famílias com descendentes japoneses. Neste relato descrevemos um paciente com manifestações de cianose que teve o seu diagnóstico confirmado através da eletroforese.

  18. Análise da freqüência de recaídas de malária por Plasmodium vivax em região não endêmica (São Paulo, Brasil Analysis of the frequency of relapses due to malaria caused by Plasmodium vivax in a non endemie area (São Paulo, Brazil

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    Marcos Boulos

    1991-04-01

    Full Text Available Em virtude da existência de poucas informações, devidamente registradas, sobre freqüência e épocas de recaídas de malária por Plasmodium vivax, contraída no Brasil, foi analisada casuística observada em região não endêmica e constituída por pacientes corretamente tratados. O índice de recaídas documentadas em São Paulo, foi alto (24,5%, com desenvolvimento precoce na maioria das oportunidades, ou seja, em tempo inferior a três meses.Very few well-established information is available about the frequency and timeliness of relapses in cases of Plasmodium vivax malaria acquired in Brazil. So, we analysed a series of correctly treated patients observed out of endemic areas. The rate of relapses seen in São Paulo, which may represent that of the parasitosis in the whole country, was high, ranging from 7.5% to 24.5%, and early in most cases, i.e. appearing by three months, what anticipates a high endemicity.

  19. Relationship between plasma and red blood cell concentrations of quinine in Brazilian children with uncomplicated Plasmodium falciparummalaria on oral therapy Relação entre as concentrações plasmáticas e eritrocitárias de quinina em crianças com malária por Plasmodium falciparum não complicada em terapia via oral

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    José L.F. Vieira

    2009-04-01

    Full Text Available We determined the relationship between plasma and red blood cell concentrations of quinine in children with uncomplicated falciparum malaria from an endemic area of Amazonian region. Quinine was determined by high performance liquid chromatography with ultraviolet detection. In the steady state the ratio between plasma and red blood cell quinine concentration was 1.89 ± 1.25 ranging from 1.05 to 2.34. This result demonstrated that quinine do not concentrate in red blood cell of Brazilian children and characterize the absence of interracial difference in this relationship.Neste estudo foi determinada a relação entre as concentrações plasmáticas e eritrocitárias de quinina em crianças com malária falciparum não complicada, oriundas de área endêmica da Região Amazônica. A quinina foi detrminada por cromatografia líquida de alta eficiência. No estado de equilíbrio, a relação foi 1,89 ± 1,25 variando de 1,05 a 2,34. Estes resultados demonstraram que a quinina não se concentra nos eritrócitos das crianças e caracterizaram a ausência de diferença racial nesta relação.

  20. Tumor de corpo carotídeo (paraganglioma: relato de dois casos submetidos a tratamento cirúrgico

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    Nelson Mesquita Junior

    Full Text Available Resumo O tumor de corpo carotídeo é uma neoplasia rara, geralmente benigna, que acomete, sobretudo, indivíduos entre a quarta e a quinta décadas de vida. Manifesta-se pela presença de massa cervical consistente localizada abaixo do ângulo da mandíbula, pulsátil e comumente indolor. Pode evoluir para dor local, disfagia, soluços, rouquidão e síndrome do corpo carotídeo hipersensível. Este artigo relata os casos de duas pacientes diagnosticadas com essa neoplasia e submetidas ao tratamento cirúrgico. A primeira foi submetida a uma ressecção em bloco do tumor, enquanto a segunda, com estadiamento mais precoce, foi tratada com uma ressecção subadventicial da lesão.

  1. Mudanças no padrão epidemiológico da malária em área rural do médio Rio Negro, Amazônia brasileira: análise retrospectiva Changes in the epidemiological pattern of malaria in a rural area of the middle Rio Negro, Brazilian Amazon: a retrospective analysis

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    Martha Cecilia Suárez-Mutis

    2007-04-01

    Full Text Available Foi realizado um estudo retrospectivo dos casos de malária ocorridos entre 1992 e 2004 no Município de Barcelos, Amazonas, Brasil, aprofundando as informações existentes na área altamente endêmica do Rio Padauri, afluente do Rio Negro. Foram identificados 16.795 casos de malária, sendo 61,4% (10.318 da área rural e 38,6% (6.477 da área urbana, com uma incidência parasitária anual média de 136,7 por mil habitantes na área urbana e 613,6 na área rural. A incidência parasitária anual média no Rio Padauri foi de 708,9/1.000. Nesse rio, foram diferenciados dois períodos epidemiológicos, sendo um denominado epidêmico (1992-1998 e outro pós-epidêmico (1999-2004. Comparando os dois períodos, a proporção homem/mulher mudou de 1,8 para 1,14, a média de idade dos pacientes passou de 17,9 para 14,8, o percentual de casos por Plasmodium falciparum reduziu-se de 51,9% para 23,7, e o percentual de lâminas com baixa densidade parasitária de P. falciparum passou de 35,3% para 44,9%, e as de P. vivax de 24% para 35%. Todas essas diferenças foram estatisticamente significativas (p A retrospective study on reported malaria cases in the municipality (county of Barcelos, Amazonas State, Brazil, was performed from 1992 to 2004, emphasizing the high endemic area along the Padauiri, an affluent of the Rio Negro. 16,795 cases were reported, 10,318 (61.4% from the rural area and 6,477 (38.6% from the urban area. Mean annual parasite index for the period was 136.7 per 1,000 inhabitants in the urban area and 613.6 per 1,000 in the rural area of Barcelos and 708.9 per 1,000 in the Padauiri area. In the latter area, two periods were considered: one epidemic, from 1992 to 1998, and the other post-epidemic, from 1999 to 2004. Comparing the two periods, the male/female ratio changed from 1.8 to 1.14, mean patient age from 17.9 to 14.8, proportion of Plasmodium falciparum cases from 51.9% to 23.7%, proportion of slides with low P. falciparum parasite

  2. Conhecimentos, práticas e percepções de profissionais de saúde sobre o tratamento de malária não complicada em municípios de alto risco da Amazônia Legal Uncomplicated malaria treatment in the Brazilian Amazon: knowledge, practices and perceptions of health workers in high-incidence municipalities

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    Claudia Garcia Serpa Osorio-de-Castro

    2011-01-01

    Full Text Available O controle da malária no Brasil conta com diagnóstico precoce e tratamento adequado e oportuno como estratégia para cura rápida e duradoura. Consequências clínicas e resistência aos antimaláricos podem resultar de falhas na prescrição, dispensação e aceitação dos profissionais aos esquemas terapêuticos propostos. Objetivou-se avaliar conhecimentos, práticas, percepções e atitudes de profissionais envolvidos na assistência farmacêutica à malária, frente ao protocolo oficial e a possíveis falhas na terapêutica. Entrevistaram-se profissionais em seis municípios na Amazônia Legal. Utilizou-se técnica de análise do discurso para determinação de categorias analíticas e sistematização. Dos 63 entrevistados, houve apenas um médico. Os demais, de nível médio, atuavam no diagnóstico, indicação e dispensação do tratamento antimalárico. O tempo de formação e de treinamento foi variável. Houve falhas na adesão ao protocolo nacional, perpassando indicação, dispensação e orientação aos pacientes. Os profissionais carecem de conhecimento para lidar com as especificidades da doença e do tratamento. A responsabilização de profissionais que não possuem o preparo necessário para a atenção sugere necessidade de políticas para a adequada capacitação e incorporação de recursos humanos.Malaria control in Brazil is based on early diagnosis and adequate and timely treatment as strategies for a rapid and long-lasting cure. Clinical consequences and resistance to antimalarials may arise from problems in prescribing, dispensing and in acceptance of therapeutic regimens by healthcare workers. We studied knowledge and practices, perceptions and attitudes of health workers participating in pharmaceutical services for malaria, regarding the official protocol and the possible flaws in therapy. Health workers from six municipalities in the Brazilian Amazon were interviewed. Speech analysis was employed as a technique

  3. Aspectos da transmissão focal de malária na Ilha de São Luis, Maranhão Aspects of the focal transmission of malaria in the Island of São Luis, Maranhão

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    Antônio Rafael da Silva

    2006-06-01

    Full Text Available O estudo foi desenvolvido com o objetivo de caracterizar um foco de transmissão de malária em Guarapiranga, município de São José de Ribamar, MA. A unidade de estudo foi o grupo familiar, aplicando-se questionário sobre identificação, situação econômica, hábitos dos moradores e características dos domicílios. Foram visitadas 54 famílias, totalizando 207 habitantes, sendo 113 do sexo masculino e 95, do feminino. 95 pessoas tinham de 5 a 24 anos. Agricultura e pesca são a base da economia local, com 64,8% das famílias auferindo renda mensal menor que um salário mínimo. A maioria das casas é construída de taipa, coberta de palha, tem piso de chão batido e não tem instalações sanitárias. Em relação à entrada de mosquitos, 62,2% são parcialmente protegidas. A água para consumo provém de cacimbas ou poços rasos em 78,8%, e o lixo é deixado a céu aberto em 53,7% dos domicílios. Foram registrados 106 casos de malária por Plasmodium vivax. O provável transmissor foi o Anopheles (N aquasalis e o tratamento com cloroquina associado à primaquina teve bons resultados.The aim of the study was to typify a malaria focus in Guarapiranga, in the district of São José de Ribamar, MA. A questionnaire regarding identification, economic situation, habits of the residents and characteristic of the residences was applied to each family. Fifty four families were visited and 207 inhabitants were interviewed (113 men and 95 women; 95 individuals were aged between 5 and 24 years old. Agriculture and fishing are the basis of the local economy; 64.8% of the families earn less than one living wage. The majority of the residences are constructed of mud walls, straw roofs, a beaten earth floor, with no basic sanitation. 62.2% of the residences are partially protected against the entry of mosquitoes. Water for domestic use comes from natural waterholes in 78.8% of the residences. Rubbish is left in the open air in 53.7% of the residences

  4. Spatial analysis for stratification of priority malaria control areas, Mato Grosso State, Brazil Análise espacial na estratificação de áreas prioritárias para o controle da malária no Estado de Mato Grosso, Brasil

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    Marina Atanaka-Santos

    2007-05-01

    Full Text Available The goal of this study was to stratify priority areas for malaria control in the State of Mato Grosso, Brazil, based on spatial analysis. The variables used were: Annual Parasite Index (API, Plasmodium falciparum/Plasmodium vivax ratio, population variation, number of families settled, and percent of deforested area. The Moran's I and Local Moran Test were applied, visualized with the Box Map and Moran Map, for 1986- 1991, 1992-1997, and 1998-2003. Box Map identified areas with high, low, and intermediate priority for control, and Moran Map identified municipalities with significant autocorrelation. In the high priority area, located in the North of Mato Grosso, malaria incidence decreased drastically despite the increase in the number of municipalities from the first to the last period. Other municipalities were added to the lower priority area, from the Southeast, Southwest, and Central-South of the State. The intermediate priority area was located along the border with neighboring States and municipalities classified as high and low priority. Spatial analysis showed the importance of the neighboring phenomenon between municipalities in defining priority areas, thus highlighting the technique's advantages for use in malaria control and surveillance.Pautado em técnicas de análise espacial, analisou-se a estratificação de áreas prioritárias para controle da malária no Estado de Mato Grosso, Brasil. Trabalhou-se Incidência Parasitária Anual, relação Plasmodium falciparum/Plasmodium vivax, variação populacional, número de famílias assentadas e percentuais da área desmatada. Foram utilizados os testes de I de Moran e Moran Local, visualizadas pelo Box Map e Moran Map, nos períodos de: 1986 a 1991, 1992 a 1997 e 1998 a 2003. Pelo Box Map identificaram-se áreas de prioridade maior, menor e intermediária, e pelo Moran Map localizaram-se municípios com autocorrelação estatisticamente significante. Na área de maior prioridade

  5. Uso do sensoriamento remoto para estudar a influência de alterações ambientais na distribuição da malária na Amazônia brasileira Use of remote sensing to study the influence of environmental changes on malaria distribution in the Brazilian Amazon

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    Cíntia Honório Vasconcelos

    2006-03-01

    Full Text Available A construção da hidroelétrica de Tucuruí, no sudeste do Estado do Pará, Brasil, em 1981, impôs grandes mudanças ambientais, desmatamentos e migração para a região. O objetivo deste trabalho é verificar a influência destas mudanças na ocorrência da malária no Município de Jacundá, Pará, Brasil, utilizando-se técnicas de sensoriamento remoto e sistemas de informações geográficas. Os parâmetros utilizados para a construção dos mapas foram: distância das estradas, classe agrossilvopastoril, distância de coleções hídricas (rios, igarapés e do reservatório e da área urbana do município. Neste estudo, verificou-se o caráter epidêmico da malária a partir da construção da barragem de Tucuruí. Sugere-se que o padrão sazonal da incidência está relacionado com o período de maior estabilidade das margens do reservatório e ocorrência de áreas alagadas, além de maior exposição de trabalhadores na época de colheita na região. Foi observado que a distribuição dos casos está relacionada com as formas de uso e ocupação da terra, principalmente em áreas de maior influência das estradas, locais onde se concentra grande parte da população.Construction of the Tucuruí hydroelectric dam in Southeast Pará State, Brazil, in 1981, caused enormous environmental changes, deforestation, and human migration to the region. This study focuses on the influence of these changes and the appearance of malaria in the municipality of Jacundá, Pará, using remote sensing and geographic information systems. The variables used to construct maps were distances from roads, farming areas, rivers, the dam, streams, and the urban area. This study confirmed the elevation of malaria to the epidemic level since the construction of the Tucuruí dam. The study suggests that a seasonal pattern of malaria incidence is associated with the flooding season and exposure of workers during harvest. Malaria cases were related to the form of

  6. Estudo sobre a eventual utilidade de raios gama na profilaxia da malária transmissível por transfusão de sangue A study on the fortuitons advantage of gamma irradiation in the prophylaxis of transmissible malaria by blood transfusion

    Directory of Open Access Journals (Sweden)

    Lúcia Maria Almeida Braz

    1998-12-01

    Full Text Available O estudo foi realizado com o objetivo de avaliar a eventual utilidade de raios gama na profilaxia da malária transmissível por transfusão de sangue, tendo sido, para isso, usados camundongos infectados pelo Plasmodium berghei. Na primeira fase, quando submetemos sangue deles retirado a 2.500 e 5.000rad, com associação ou não de metronidazol, não obtivemos sucesso, já que todos os animais antes sem a parasitose apresentaram parasitemia e morreram após inoculação do sangue irradiado. Porém, ocorreu êxito parcial na segunda fase, ao serem empregados 10.000 e 15.000rad, porquanto 20% e 40% dos roedores, respectivamente, embora tenham ficado infectados, sobreviveram, com posterior negativação quanto à presença do P. berghei.This study was carried out to evaluate the fortuitons advantage of using gamma irradiation in the prophylaxis of transmissible malaria by blood transfusion, with mice as the experimental model. In the first step, when the infected blood with Plasmodium berghei was submitted to 2,500rad and 5,000rad, with or without metronidazol, there was no success, because the animals presented parasitaemia and died after inoculation of irradiated blood. However, there was partial success in the second step, when the infected blood received 10,000 and 15,000rad, and was inoculated in mice, which showed infection, and presented a survival rate of 20% and 40%, respectively, with later negativation of blood infected by P. berghei.

  7. Baixa aderência e alto custo como fatores de insucesso do uso de mosquiteiros impregnados com inseticida no controle da malária na Amazônia Brasileira Low adherence and high cost as failure factors of impregnated bed nets with insecticide for malaria control in the Brazilian Amazon

    Directory of Open Access Journals (Sweden)

    João Barberino Santos

    1999-08-01

    Full Text Available Em 1992, durante um ensaio com mosquiteiros impregnados com deltametrina, conduzido em Porto Murtinho, município de Costa Marques, Rondônia, na Amazônia Brasileira, analisou-se a aderência e os fatores econômicos capazes de reduzir o impacto do uso de mosquiteiros impregnados sobre a morbidade da malária. Os mosquiteiros impregnados tiveram excelente receptividade pela população local. No entanto, a aderência foi muito baixa, principalmente pelos adultos maiores de 15 anos de idade e, durante a estiagem. O preço do mosquiteiro impregnado foi calculado em US$18,83 para casal e, em US$13,82, para solteiro. Apesar das vantagens econômicas do emprego dos mosquiteiros impregnados em larga escala, desde que subsidiados pelas agências governamentais, a baixa aderência verificada, aliada aos fatores epidemiológicos locais, não permitem indicar o uso de mosquiteiros impregnados como medida de proteção em massa na Amazônia.In 1992 during a trial with deltamethrin-impregnated bed nets conducted in Porto Murtinho, municipality of Costa Marques, Rondonia, in the Brazilian Amazon, we investigated community compliance and the economic aspects capable of reducing the impact of this intervention on malaria morbidity. Impregnated bed nets were well accepted by the local population. However, compliance was found to be very low among adults over 15 years of age and mainly during the dry season. The cost of impregnated bed nets was US$18.83 for double-bed nets and US$13.82 for single bed nets. Despite the economic advantages of using impregnated bed nets subsidized by the government, the low compliance and local epidemiological factors do not allow to indicate the use of impregnated bed nets for mass malaria control in the Amazon region.

  8. Aspectos sócio-econômicos dos indivíduos com malária importada na região metropolitana de São Paulo, Brasil: I - Caracterização da população e conhecimento sobre a doença Social and economic aspects of patients with imported malaria in the metropolitan region of S. Paulo City, S. Paulo State, Brazil: I - Characterization of the population and knowledge of the disease

    Directory of Open Access Journals (Sweden)

    Maria José Chinelatto Pinheiro Alves

    1990-08-01

    Full Text Available Com o objetivo de conhecer o perfil sócio-econômico dos indivíduos que se deslocaram das áreas endêmicas de malária do país, foram estudadas 566 pessoas com suspeita de malária que procuraram a confirmação diagnostica no Laboratório de Malária da Região Metropolitana de São Paulo da Superintendência de Controle de Endemias (SUCEN. As informações foram obtidas através da aplicação de formulário, no período de novembro de 1986 a junho de 1987. Da população estudada, 345 (61,0% residiam na área endêmica, 479 (84,6% eram do sexo masculino, 513 (90,7% estavam na faixa etária de 15 a 55 anos e 307 (54,2% apresentaram hemoscopia positiva para plasmódio. Com relação à ocupação na área de transmissão, observou-se que 109 (19,3% estavam ligados a atividade de extração de minerais, 74 (13,2% à agricultura e 46 (8,1% à atividade de transporte. A análise da escolaridade mostrou que 486 (85,9% tinham 1° ou 2° grau. Quanto ao conhecimento sobre a doença, 384 (67,8% declararam pelo menos 1 malária anterior e 491 (86,8% associavam à doença a presença do vetor. Dentre os 221 indivíduos residentes em São Paulo, 207 (93,7% conheciam o risco de contrair malária por ocasião do deslocamento para área de transmissão. Daqueles residentes na área endêmica, 336 (97,4% tinham conhecimento do risco de contrair a doença naquela região. O intervalo transcorrido entre os primeiros sintomas e a procura de atendimento médico em 386 (68,2% indivíduos variou de 0 a 3 dias. As freqüências das variáveis estudadas mostraram de acordo com o resultado hemoscópico e o local da residência, diferenças estatísticas relevantes.With a view to discovering the social and economic characteristics of people from endemic malarial areas of Brazil, 566 suspected malaria cases were studied at the S. Paulo City Metropolitan Region Malaria Laboratory. Data were obtained by means of the application of standardized questionnaires over the

  9. Compatibilidade de Dicyma pulvinata com defensivos agrícolas e eficiência do biocontrole do mal-das-folhas da seringueira em campo Compatibility of Dicyma pulvinata with pesticides and biocontrol efficiency of South American leaf blight of rubber tree under field conditions

    Directory of Open Access Journals (Sweden)

    Débora Ferreira Melo

    2008-02-01

    Full Text Available O objetivo deste trabalho foi avaliar quatro isolados do fungo antagonista Dicyma pulvinata quanto à compatibilidade com defensivos agrícolas e adjuvantes, e a eficiência desses isolados no controle do mal-das-folhas (Microcyclus ulei da seringueira (Hevea sp. em campo. A compatibilidade dos isolados com defensivos e adjuvantes foi avaliada com base no crescimento micelial e na esporulação do fungo, em testes conduzidos in vitro. Para avaliação da eficiência do antagonista contra M. ulei, em campo, os quatros isolados do antagonista foram comparados ao controle exercido pelo tratamento com os fungicidas propiconazol + mancozeb. Os ensaios conduzidos em laboratório indicaram a incompatibilidade de D. pulvinata com os fungicidas benomyl, carbendazim, mancozeb, propiconazol e, ainda, com o inseticida acaricida endosulfan. Dois dos adjuvantes testados (Tween 20 e Tween 80 não afetaram o desenvolvimento do fungo. Foi comprovada a ação do antagonista D. pulvinata sobre M. ulei, em campo, com destaque para os isolados CEN 62 e CEN 93, que apresentaram eficiência de controle semelhante ao tratamento fungicida padrão.The objective of this work was to evaluate four isolates of the antagonist fungus Dicyma pulvinata in terms of its compatibility with chemical pesticides and adjuvants products, and the efficiency of these isolates as biocontrol agent against South American leaf blight (Microcyclus ulei of rubber tree (Hevea sp. under field conditions. Isolates compatibility with chemical pesticides and adjuvants was evaluated on mycelial growth and fungus sporulation in vitro. To assess the efficiency of the antagonist against M. ulei under field conditions, the four isolates were compared to the control by the fungicide mixture propiconazol + mancozeb. The assays showed incompatibility of the antagonistic fungus with the fungicides benomyl, carbendazim, mancozeb, propiconazol, besides the insecticide-acaricide endosulfan. Two of the adjuvants

  10. Avaliação dos níveis das transaminases dos pacientes com infecção pelo Plasmodium vivax atendidos em um centro de referência para tratamento da malária no Estado de Mato Grosso

    Directory of Open Access Journals (Sweden)

    Elisane de Freitas Pereira

    2017-11-01

    Full Text Available Objetivo: Analisar os marcadores hepáticos (transaminases em pacientes com malária causada pelo Plasmodium vivax. Métodos: Trata-se de um estudo transversal retrospectivo, incluindo pacientes que apresentaram monoinfecção pelo P. vivax. O teste de Mann-Whitney U ou o teste t de Student foram utilizados para comparar a atividade média das transaminases de acordo com a classificação clínica e epidemiológica do paciente infectado. O teste de Kruskal-Wallis foi utilizado para comparar a média da atividade das transaminases de acordo com a classificação da infecção. Valores de p<0,05 foram considerados significativos. Resultados: Indivíduos menores de 7 anos apresentaram maior atividade da transaminase glutâmico oxalacética (TGO e da transaminase glutâmico pirúvica (TGP — respectivamente, 68,7 U/L e 79,8 U/L — em relação a pacientes com idade de 8 a 59 anos (TGO 29,8 U/L e TGP 39,2 U/L e acima de 60 anos (TGO 32,5 U/L e TGP 34 U/L. A média da dosagem sérica de TGO de todos os pacientes incluídos no estudo foi de 31,99 U/L e de TGP foi de 41,1 U/L. A atividade de TGP nos pacientes primoinfectados foi maior que nos reinfectados ou com recaída, sendo 65,6 U/L contra 36,2 U/L e 32,7 U/L, respectivamente. Conclusão: Crianças apresentam maior atividade de transaminases que os indivíduos maiores de sete anos de idade. Pacientes com infecção prévia pelo P. vivax apresentam menores valores séricos da atividade das transaminases do que os primoinfectados. Indivíduos com episódios de recaída apresentam menores valores das enzimas avaliadas do que aqueles com reinfecção ou primoinfecção.

  11. Malaria transmission model for different levels of acquired immunity and temperature-dependent parameters (vector Modelo de transmissão de malária em diferentes níveis de imunidade e de parâmetros temperatura-dependentes (vetor

    Directory of Open Access Journals (Sweden)

    Hyun M Yang

    2000-06-01

    Full Text Available OBJECTIVE: Describe the overall transmission of malaria through a compartmental model, considering the human host and mosquito vector. METHODS: A mathematical model was developed based on the following parameters: human host immunity, assuming the existence of acquired immunity and immunological memory, which boosts the protective response upon reinfection; mosquito vector, taking into account that the average period of development from egg to adult mosquito and the extrinsic incubation period of parasites (transformation of infected but non-infectious mosquitoes into infectious mosquitoes are dependent on the ambient temperature. RESULTS: The steady state equilibrium values obtained with the model allowed the calculation of the basic reproduction ratio in terms of the model's parameters. CONCLUSIONS: The model allowed the calculation of the basic reproduction ratio, one of the most important epidemiological variables.OBJETIVO: Propõe-se um modelo compartimental para descrever a transmissão de malária, levando em consideração duas populações envolvidas: o hospedeiro humano e o vetor mosquito. MÉTODOS: Desenvolveu-se um modelo matemático baseado nas seguintes características: em relação ao hospedeiro humano, assumiu-se a existência de imunidade adquirida e de memória imunológica que, em uma reinfecção, leva ao reforço da resposta imune; em relação ao vetor mosquito, levou-se em consideração que o período médio de desenvolvimento desde ovo até mosquito adulto e o período de incubação extrínseco de parasitas (transformação de mosquitos infectados mas não-infecciosos em mosquitos infecciosos são dependentes de temperatura ambiente. RESULTADOS: Foram obtidos os valores do equilíbrio no estado estacionário do modelo proposto. Da análise da estabilidade dos pontos de equilíbrio, foi determinada a razão de reprodutibilidade basal. CONCLUSÕES: Foi obtida uma variável epidemiológica importante, a razão de

  12. Variable impact of Malaysia's national language planning on non-Malay speakers in Sarawak Impacto variável do planejamento linguístico nacional da Malásia sobre não falantes do Malaio em Sarawak

    Directory of Open Access Journals (Sweden)

    Su-Hie Ting

    2012-06-01

    Full Text Available The study examined the impact of the national language policy on the language use of three main ethnic groups in the Malaysian state of Sarawak. The data analyzed was based on a sociolinguistic survey on language use in six domains that involved 937 Malay, Chinese and Iban adolescents from three major towns in Sarawak. The results showed that the use of Bahasa Malaysia exceeded English usage for all three ethnic groups, showing the success of compulsory education in the national language. However, the language planning has greater impact on the Iban than on the Chinese who are shifting away from the ethnic languages of the Chinese sub-groups to Mandarin Chinese. The availability of an alternative standard language with international standing which also functions as a symbol of cultural solidarity compromises the impact of the national language policy.Este estudo examinou o impacto da política de ensino da língua nacional de três principais grupos étnicos no estado malaio de Sarawak. Os dados analisados basearam-se em uma pesquisa sociolinguística sobre o uso da língua em seis domínios e envolveu 937 adolescentes malaios, chineses e Iban de três grandes cidades de Sarawak. Os resultados mostraram que o uso da língua Bahasa da Malásia superou o uso do inglês para todos os três grupos étnicos, comprovando o sucesso da escolaridade obrigatória em língua nacional. No entanto, o planejamento do estudo da língua tem maior impacto sobre o Iban do que sobre os chineses. Estes estão se afastando das línguas étnicas dos subgrupos chineses para o chinês Mandarim. A disponibilidade de uma língua alternativa padrão, com prestígio internacional, que também funciona como um símbolo de solidariedade cultural, compromete o impacto da política de ensino da língua nacional.

  13. Du Mal-être au votre extrême

    OpenAIRE

    Gethin,, Amory; Jenmana,, Thanasak

    2017-01-01

    Note d'analyse de l'Observatoire du Bien-être du CEPREMAP; The rise of populism and the failure of traditional parties during the 2017 French presidential election calls to question the relevance of traditional determinants of voting. Given the difficult economic context associated with François Hollande’s term, to what extent has the increasing pessimism in France contributed towards anti-establishment voting?Available surveys reveal two remarkable phenomena. The extremes, particularly the e...

  14. Problematica del mal de las vacas locas y consecuencias

    OpenAIRE

    Fernandez Boj, Olga

    2003-01-01

    El presente trabajo se basa en el estudio sobre una enfermedad que causa una especie de locura en los bovinos denominada encefalitis espongiforme bovina, (EEB) y que también puede afectar al hombre con el nombre de Creutzfeldt-Jakob. La EEB (enfermedad espongiforme bovina) esta vinculada con el scrapie una enfermedad también prionica que se conoce desde hace 250 años y que afecta a las ovejas. Todo comenzó 1883 cuando una vaca tenia los mismos signos clínicos que las ovejas, per...

  15. Videogame: é do bem ou do mal? Como orientar pais

    Directory of Open Access Journals (Sweden)

    Luciana Alves

    2011-06-01

    Full Text Available Desde a década de 70 milhares de crianças, adolescentes e adultos praticam jogos de computador ou videogame. O objetivo deste artigo foi identificar os efeitos deste artefato tecnológico para a cognição, sua aplicabilidade e sua influência sobre o comportamento e a saúde do jogador e, desta forma, delinear orientações para pais e profissionais de saúde que lidam com crianças e adolescentes. Na primeira parte do artigo são apresentados alguns efeitos negativos e positivos dos jogos; na segunda é proposto um conjunto de orientações que podem tornar a brincadeira mais segura; e na última parte, as considerações finais. Concluiu-se que o videogame é uma ferramenta capaz de aperfeiçoar as habilidades cognitivas e perceptivas, sendo os jogos educacionais apontados como uma experiência benéfica aos seus usuários, e que as repercussões negativas se referem, principalmente, ao efeito daqueles com conteúdo de violência.

  16. PROBLEMAS INVERSOS MAL COLOCADOS EM QUÍMICA

    Directory of Open Access Journals (Sweden)

    João P. Braga

    Full Text Available What is an ill-posed inverse problem? The answer to this question is the main objective of the present paper and the pre-requisite to follow the material requires only elementary calculus. The first mathematical formulation of an inverse problem, due to N. H. Abel, together with the fundamental work by Jacques Hadamard, are explored at the beginning of the paper. A prototype system is used to consider the regularization concept. Three numerical methods, the Tikhonov regularization, the decomposition into singular values and the Hopfield neural networks, applied to remove the singularity are examined. General aspects of the ill-posed inverse problems in chemistry with emphasis in thermodynamics and a set of general rules for other areas of science are also analyzed.

  17. O mal-estar docente em gestores escolares

    Directory of Open Access Journals (Sweden)

    Cátia Cristina Xavier Mazon

    2013-08-01

    Full Text Available This research aimed to identify and analyze the impact of stressful events associated with the school administrators in teacher malaise. 29 managers participated in his capacity as directors or deputy directors of the municipal system, the interior of São Paulo, with responses to the Inventory IMPIL (Evaluación Psicológica Del Estrés por InestabilidadLaboral - FIGUEROA; SCHUFER, 2006. The results indicate the presence of stressors in all areas assessed at different rates. The highest ranking stressors were concerns with health, emotional Diseases and economic concerns. The degree of discomfort tends to increase with age, but since the entry into this function. The extensive powers of management, indicate the occurrence of different degrees of impact between the groups, demonstrating that subjectivity needs to be considered for proposing improvements in working conditions and health organizations. Social changes, the demands of educational reforms and lack of recognition of the profession were associated with teacher malaise.

  18. Observation of the new isomer 32mAl

    International Nuclear Information System (INIS)

    Robinson, M.; Halse, P.; Lewitowicz, M.; Saint-Laurent, M.G.

    1995-01-01

    A new isomer in the neutron-rich isotope 32 Al has been identified among the fragmentation products of a 40 Ar 16+ beam using the LISE spectrometer at GANIL. The population of the isomeric state was inferred from the detection of γ-radiation following its decay in coincidence with its respective heavy-ion implantation signal. The half-life of 32m Al was determined to be 240 ± 30 ns. (author)

  19. MAL MEDIS DI MAKASSAR DENGAN PENDEKATAN BANGUNAN SEHAT

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    Nurpuspitasari Nurpuspitasari

    2014-12-01

    Full Text Available These planning and designing are aimed to design Medical Mall in Makassar with healthy building approach, although in macro such as deciding the location and footprint, and also in micro such as deciding the form and its appearance, program, measuring rooms and relating each rooms, structure, material, until its equipments. The method which is used is Descriptive, the data comes from secondary data, those are literature study through books, short papers, references, standard, internet and others written sources that is related with planning and designing Medical mall in Makassar with healthy building approach. The results of these designing are creating a place in servicing health and others facilities supporting medical health in a integrated building, that is based comfortable and save environment fulfill requirements of physiological, psychological and free from spreading diseases

  20. Tvorba marketingové strategie malé firmy

    OpenAIRE

    Šťastná, Jana

    2011-01-01

    This bachelor thesis deals with marketing strategy of mid-sized company called TRIPOR Ltd., the business deals with buying and selling porcelain and glass .The business is located in Klášterec nad Ohří. The aim of this work is to analyze the current marketing strategy of the company, its evaluation, suggestion and marketing strategy of the company. The work is divided into two chapters. The first chapter deals with the theoretical part, which describes the particular theory of marketing. The ...

  1. Shale engineering application: the MAL-145 project in West Virginia

    Energy Technology Data Exchange (ETDEWEB)

    Vassilellis, George D.; Li, Charles; Bust, Vivian K. [Gaffney, Cline and Associates (United States); Moos, Daniel; Cade, Randal [Baker Hughes Inc (United States)

    2011-07-01

    With the depletion of conventional fossil fuels and the rising energy demand, oil shale and shale gas are becoming an important component of the oil and gas markets in North America. The aim of this paper is to present a novel methodology for predicting production in shale and tight formations. This method, known as the shale engineering approach and modeling, provides reservoir simulations based on modeling the propagation of the simulated rock volume. This technique was applied to an Upper Devonian shale formation in West Virginia, United States, and was compared to available data such as production logs and downhole microseismic data. Results showed a good match between the shale engineering approach data and early well performance. This paper presented a new reservoir simulation methodology which is successful in forecasting production and which can also be used for field development design and optimization.

  2. Cephalopods belong to a very diverse group of ani- mals ...

    African Journals Online (AJOL)

    spamer

    Rosen 1979). Exploitation of cephalopods is on the increase .... factors, rather than a single parameter (e.g. temperature). Cause-and-effect elements between these modifiers are integral to the ..... illecebrosus, in the Northwest Atlantic. Aquat.

  3. O mal-estar docente em gestores escolares

    Directory of Open Access Journals (Sweden)

    Cátia Cristina Xavier Mazon

    2013-01-01

    Full Text Available Esta investigación tuvo como objetivo identificar y analizar el impacto de eventos estresantes en los administradores de escuelas asociado al malestar docente. Participaron 29 administradoras en su calidad de directoras o subdirectoras de la red municipal del interior del Estado de São Paulo, con las respuestas a la IMPIL (Evaluación Psicológica Del Estrés por Inestabilidad Laboral - FIGUEROA; SCHUFER, 2006. Los resultados indican la presencia de factores estresantes en todas las áreas evaluadas en diferentes índices. Los mayores factores de estrés fueron las preocupaciones con la salud, enfermedades emocionales y las preocupaciones económicas. El grado de molestia tiende a aumentar con la edad, pero están presentes en esta función desde su iniciación. Los amplios poderes de gestión, indican la ocurrencia de diferentes grados de impacto entre los grupos, demostrando que la subjetividad debe ser considerada para las propuestas de mejoras de las condiciones de trabajo y organizaciones de salud. Las aceleradas transformaciones sociales, las exigencias de reformas educativas y la falta de reconocimiento de la profesión se asociaron al malestar docente.

  4. Daytime encopresis associated with gland mal epileptic seizures: case report.

    Science.gov (United States)

    Oyatsi, D P

    2005-08-01

    Sphincteric incontinence of stool and urine are not unusual features of generalised epileptic seizures. Isolated secondary encopresis as a manifestation of an epileptic seizure is unusual. This report is of, a four year old boy, with daytime secondary non-retentive encopresis. The onset of encopresis was preceded by several episodes of nocturnal generalised tonic clonic epileptic seizures. An electroencephalogram showed features consistent with complex partial seizures. He was commenced on anti-epileptic treatment with phenytoin sodium, and by the third day of treatment, the patient had achieved stool control.

  5. ‘Comprendre le mal extrême.’

    Directory of Open Access Journals (Sweden)

    Christian Ruby

    2003-10-01

    Full Text Available Fondée sur l'exercice d'une terreur politique et sur un processus d'extermination radicale, une nouvelle forme de pouvoir d'État est née au 20 e  siècle. Afin de parler avec précision de cette nouvelle réalité, il fallait forger un concept encore inédit dans les typologies du pouvoir léguées par Platon et Montesquieu. La philosophe allemande (émigrée aux États-Unis, où elle prendra la nationalité américaine Hannah Arendt a proposé, en 1951, le concept de ...

  6. Obchodní strategie malého podniku

    OpenAIRE

    Hourová, Tereza

    2013-01-01

    The thesis deals with the business strategy of a middle-sized entrepreneur in the food manufacturing industry. The theoretical part explains basic terms, introduces methods of a strategic analysis and describes basic approaches to formulating the strategy. The practical part contains the strategic analysis of a specific entrepreneur created using the PEST analysis, the Porter five forces analysis, and the Value Chain Analysis. The practical part also includes suggested business strategies det...

  7. O CUIDADOR DOMICILIAR DE PACIENTE IDOSO COM MAL DE ALZHEIMER

    Directory of Open Access Journals (Sweden)

    Rafaelle Lins Barbosa

    2012-01-01

    Full Text Available Se trata de estudio de caso con objetivo de entender cómo la atención diaria en casa, en la perspectiva del cuidador familiar de anciano con la Enfermedad de Alzheimer. El estudio fue llevado a cabo con un cuidador familiar en la ciudad de Alfenas-MG, Brasil, de mayo y junio de 2010, a través de entrevista con pregunta directa. Fueron identificados dos categorías: el cuidado tomado con el paciente con Alzheimer y el cuidador del paciente con Alzheimer. El cuidador en la atención diaria dedica su tiempo integral, vive dificultades financieras y de convivio con cambios del paciente, contemplando en carga excesiva diaria que compromete el ocio y genera problemas de salud, mientras buscando el apoyo en la fe. Aprehender las dificultades enfrentadas por el cuidador propicia el equipo de salud para direccionar y llevar a cabo estrategias de apoyo para el cuidador enfrentar la condición crónica del familiar.

  8. Mal-estar no pós-neoliberalismo

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    Jamie Peck

    2012-03-01

    Full Text Available O início da crise financeira global em 2008 foi interpretado como um desafio fundamental à governança neoliberal. O artigo explora algumas das consequências de curto e longo prazo da crise econômica em relação aos processos da neoliberalização e propõe referências teóricas para uma compreensão adequada da natureza desse modelo político e socioeconômico e de suas manifestações e desenvolvimentos socioespaciais.The onset of the global financial crisis has been widely interpreted as a fundamental challenge to neoliberal governance. The article explores some of the near-term and longer-run consequences of the economic crisis for processes of neoliberalization, suggesting some theoretical references for the adequate understanding of the nature of neoliberalization and its evolving sociospacial manifestations.

  9. Meio ambiente e saúde: metodologia para análise espacial da ocorrência de malária em projetos de assentamento Medio ambiente y salud: metodología para análisis espacial de la ocurrencia de malaria en proyectos de asentamiento Environment and Health: a methodological approach for spatial assessment of malaria transmission in colonization projects in the Brazilian Amazon

    Directory of Open Access Journals (Sweden)

    Marcia Caldas de Castro

    2007-12-01

    Full Text Available A transmissão de malária em projetos de assentamento na Amazônia, definida como malária de fronteira, é resultado de um intrincado processo envolvendo fatores biológicos, ecológicos, socioeconômicos e comportamentais, apresentando uma transição temporal de altas a baixas taxas ao longo de aproximadamente oito anos. Como resultado, um dos grandes desafios é a compreensão desse processo, através da identificação das variáveis determinantes da transmissão, considerando-se dimensões temporais e espaciais. Neste artigo é apresentada uma abordagem metodológica que caracteriza perfis de risco de malária em projetos de assentamento, a partir de uma análise multidisciplinar. Composta de três etapas, a abordagem combina análise espacial, geoestatística e modelos de Grade of Membership. Os resultados ressaltam a importância de medidas de controle diferenciadas de acordo com o estágio do projeto de assentamento (implementação recente ou antiga e o nível de transmissão em cada localidade.La transmisión de malaria en proyectos de asentamiento en la Amazonia, definida como malaria de frontera, es el resultado de un intrincado proceso, involucrando factores biológicos, ecológicos, socioeconómicos y comportamentales, presentando una transición temporal de altas a bajas tasas a lo largo de aproximadamente ocho años. Como resultado, uno de los grandes desafíos es la comprensión de ese proceso, a través de la identificación de las variables determinantes de la transmisión, habiéndose considerado dimensiones temporales y espaciales. En este artículo es presentado un abordaje metodológico que caracteriza perfiles de riesgo de malaria en proyectos de asentamiento, a partir de un análisis multidisciplinario. Compuesto de tres etapas, el abordaje combina análisis espacial, geoestadística y modelos de Grade of Membership. Los resultados resaltan la importancia de medidas de control diferenciadas, de acuerdo a la etapa del

  10. Malária não complicada por Plasmodium vivax e P. falciparum no Brasil: evidências sobre fármacos isolados e associações medicamentosas empregados em esquemas terapêuticos recomendados pelo protocolo terapêutico oficial Uncomplicated Plasmodium vivax and P. falciparum malaria in Brazil: evidence on single and combined drug treatments recommended by official guidelines

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    Letícia Figueira Freitas

    2007-10-01

    Full Text Available A malária é a endemia parasitária mais importante no mundo. No Brasil, 60% do território são favoráveis à transmissão, com cerca de 500 mil casos por ano. A doença não se distribui geograficamente de forma homogênea, fato que pode explicar diferenças na eficácia e efetividade dos tratamentos. Para identificar as evidências que poderiam ter embasado os tratamentos recomendados pelo Manual de Terapêutica da Malária 2001, foi realizada uma revisão dos estudos que abordassem tratamentos com antimaláricos no Brasil entre 1980 e 2005. Foram encontrados poucos estudos, e com baixa qualidade metodológica, nenhum deles capaz de gerar recomendações para protocolos baseados em evidência. Os artigos publicados após 2001 apresentaram nível de evidência maior, segundo classificação utilizada para definição de níveis de evidência farmacológico-clínicos. Espera-se que tais estudos também orientem conduta na próxima revisão do manual, prevista para o ano de 2007. Constatou-se que as referências do manual, utilizadas como base para recomendação dos tratamentos, são publicações desatualizadas e possivelmente consideradas clássicas, mas com pouca especificidade para região geográfica, população e/ou tipo de malária.Malaria is the most important endemic parasitic disease in the world. Conditions are favorable for transmission of the disease in 60% of Brazil's territory. Over 500,000 cases per year are recorded in the country. However, the geographic distribution is uneven, which may explain differences in the efficacy and effectiveness of antimalarial drugs. We conducted an extensive literature review of antimalarial treatment in Brazil from 1980 to 2005 in order to identify evidence that might have been available for the 2001 Edition of the Malaria Treatment Manual, the official Ministry of Health guidelines. Only a few studies, of low methodological quality, were identified by the search. None of the studies would

  11. Estrutura comunitária e amplitude ecológica do componente lenhoso de uma floresta de restinga mal drenada no sudeste do Brasil Woody-layer structure and ecological amplitude of a poorly drained beach-ridge forest in southeastern Brazil

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    Luis Fernando Tavares de Menezes

    2010-09-01

    Full Text Available Analisamos a estrutura de uma floresta mal drenada na Restinga da Marambaia, RJ, e a amplitude ecológica das espécies quanto à tolerância à inundação do solo. Foram amostrados em 50 parcelas contíguas de 10 X 10m (0,5 ha, indivíduos com diâmetro do caule a altura do peito (DAP >2,5 cm. Registramos 1.223 indivíduos vivos (distribuídos em 24 famílias, 43 gêneros e 57 espécies. O índice de diversidade de Shannon (H' foi de 2,87 e a equabilidade (J' foi de 0,68. A densidade total foi de 2.446 ind. ha-1 e a área basal de 25,14 m². ha-1. As famílias mais ricas em espécies foram Myrtaceae (13, Leguminosae (5, Annonaceae, Euphorbiaceae, Myrsinaceae e Sapindaceae (4. Dez espécies apresentaram valor de importância (VI acima de nove, correspondendo o somatório de seus valores a 75% do VI total. As espécies com maiores valores de VI foram Tapirira guianensis Aubl. (42,42, Amaioua intermedia Mart. ex Roem. & Schult. (40,77 e Chaetocarpus myrsinites Baill. (39,98, que juntas detiveram 41% do VI total. A comunidade arbórea analisada foi composta principalmente por espécies preferenciais de áreas secas, ou seja, espécies com preferência por alagamento periódico do solo ou solos mais secos, mas não com alagamento permanente ou quase permanente do solo. A maior similaridade da floresta mal drenada da Marambaia foi observada com as florestas inundáveis do Parque Nacional de Jurubatiba, RJ (21,4 e 23,8%. Nossos resultados permitiram concluir que não existe uma flora particular para as formações inundáveis nas restingas do sul e sudeste brasileiro e que mudanças do padrão florístico da vegetação dessas áreas ocorrem em função da proximidade da fonte de propágulos de espécies com alta tolerância à inundação do solo e secundariamente relacionada a questões fitogeográficas, ligadas à limitação da distribuição de espécies pelas condições climáticas das regiões subtropicais.We analyzed the structure of a

  12. Epidemiological and ecological aspects related to malaria in the area of influence of the lake at Porto Primavera dam, in western São Paulo State, Brazil Aspectos epidemiológicos e ecológicos relacionados à malária na área de influência do lago da Represa de Porto Primavera, região oeste do Estado de São Paulo, Brasil

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    Almério de C. Gomes

    2008-10-01

    this paper.Foi realizada pesquisa na área de influência do lago da Usina Hidrelétrica de Porto Primavera, região oeste do Estado de São Paulo, para estudar aspectos ecológicos e epidemiológicos da malária na localidade e acompanhar o perfil das populações de anofelinos frente às mudanças decorrentes do impacto ambiental pela formação do lago. Mosquitos capturados foram analisados pelo Índice de Abundância de Espécies Padronizado (IAEP, antes e durante o enchimento do reservatório (cotas 253 e 257 m. A população humana local foi estudada por meio de teste parasitológico (gota espessa e esfregaço sangüíneo, testes moleculares (PCR e testes sorológicos. A sorologia consistiu na reação de ELISA com peptídeos sintéticos correspondentes à porção repetitiva da proteína circumsporozoíta (CSP de Plasmodium vivax clássico, e suas variantes VK247 e "vivax-like", P. malariae e P. falciparum; e reação de Imunofluorescência Indireta (RIFI com formas assexuadas de P. vivax, P. malariae e P. falciparum. Os resultados do estudo entomológico indicaram que, embora a população de Anopheles darlingi tenha aumentando após o enchimento, permaneceu em baixa densidade. Não foi detectada malária nem a presença de parasitos ou de DNA parasitário nos habitantes estudados. No entanto, foi observada baixa freqüência de anticorpos contra formas assexuadas e significativa prevalência de anticorpos contra esporozoítos de P. vivax e suas variantes, P. falciparum e P. malariae, que poderiam decorrer de contatos prévios, recentes ou não, com plasmódios humanos ou símios (o ciclo silvestre foi evidenciado em estudo paralelo realizado na mesma área. Por outro lado, estes resultados sugerem que, como em outros lugares onde existem vetores potenciais da malária, as condições epidemiológicas poderiam potencialmente permitir a transmissão da malária na área de influência do lago de Porto Primavera, se indivíduos infectados fossem introduzidos em n

  13. Colonização micorrízica arbuscular e tolerância ao mal-do-Panamá em mudas de banana-maçã Colonisation of arbuscular mycorrhiza and tolerance to Panama disease in seedlings of the maçã banana

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    Deusiane Batista Sampaio

    2012-09-01

    Full Text Available O objetivo desse trabalho foi avaliar o efeito da colonização micorrízica arbuscular na tolerância da bananeira, cv. Maçã, ao mal-do-Panamá, sob diferentes fontes de nutrientes. Utilizou-se um delineamento inteiramente casualizado com fatorial 2 x 4 [2 densidades de esporos de FMA nativos (D1 - 3.500 esporos kg-1 solo e D2 - 7.000 esporos kg-1 solo e 4 diferentes concentrações de fontes de nutrientes - três de solução nutritiva (SN 40%, SN 70% e SN 100% e uma de biofertilizante 100% (B4] com três repetições. Após o plantio inoculou-se Fusarium oxysporum f.sp. cubense e posteriormente avaliou-se matéria seca da parte aérea (MSPA, o teor de fósforo foliar (P, a colonização micorrízica, o pH do solo e o índice de severidade da doença (ID. As diferentes fontes de nutrientes influenciaram a matéria seca da parte aérea, o teor de fósforo, a colonização micorrízica e o índice de severidade da doença, porém não influenciaram o pH da solução do solo. O biofertilizante não atendeu à demanda nutricional das plantas, as quais se mostraram pouco desenvolvidas. Porém proporcionou intensa colonização micorrízica e menor índice de severidade da fusariose, o qual aumentou com a adubação mineral.The aim of this study was to evaluate the effect of the colonization of arbuscular mycorrhiza on the tolerance to Panama disease of the banana plant cv. maçã under different sources of nutrients. A completely randomized design was employed, having a 2 x 4 factorial [2 densities of native FMA spores (D1 - 3,500 spores kg-1 soil and D2 - 7000 spores kg-1 soil and four different concentrations of nutrient sources - three of a nutrient solution (SN 40%, SN 70% and SN 100% and a 100% solution of bio-fertiliser (B4], with three replications. After planting, the seedlings were inoculated with Fusarium oxysporum f.sp. cubense, and later the shoot dry matter, leaf phosphorus content, mycorrhizal colonization, soil pH and disease

  14. External hydrocephalus (benign extra-axial collections of infancy) - review of 15 cases; Hidrocefalia externa colecao extra-axial benigna da infancia - revisao de 15 casos

    Energy Technology Data Exchange (ETDEWEB)

    Machado Junior, Marcos Alberto da Costa; Matos, Paulo Engracio de; Barbosa, Veronica Aline [Fundacao Monte Tabor, Salvador, BA (Brazil). Hospital Sao Rafael. Servico de Bioimagem; Vieira, Naiara Argollo [Hospital Salvador, BA (Brazil); Vieira, Lauro Conceicao Nascimento [Fundacao Monte Tabor, Salvador, BA (Brazil). Hospital Sao Rafael. Servico de Ressonancia Magnetica; Puglio, Nadja; Bacelar, Aroldo [Fundacao Monte Tabor, Salvador, BA (Brazil). Hospital Sao Rafael

    1997-03-01

    The authors studied 15 cases of external hydrocephalus over a 7-year period (September 1987 to May 1995). External hydrocephalus is a condition in which infants with rapidly enlarging heads are found to have a MRI showing widening of subarachnoid space with mild or no ventricular dilatation. Some of the MRI were compared with those of patients with cerebral atrophy and some etiopathogenic hypothesis are presented. These findings indicate that external hydrocephalus is an age-related self-limited condition occurring in infants with open cranial sutures and that it usually resolves without intervention after the second or third year of age. (author) 21 refs., 4 figs.

  15. La maca roja (Lepidium Meyenii) y su acción en el tratamiento de la hiperplasia prostática benigna

    OpenAIRE

    Alvarado Alvarado, Jesenia Ludy; Alvarado Alvarado, Jesenia Ludy

    2015-01-01

    La Maca (Lepidium Meyenii) es una valiosa raíz de reserva, llamada hipocólito, utilizada como alimento y sobre todo como remedio natural desde los tiempos de los incas. Nativa del Perú, la Maca se ha extendido por todo el mundo como planta medicinal, y aparece citada en la medicina Herbal Peruana para estimular el sistema inmunitario, tratar la anemia, la tuberculosis, los desórdenes menstruales, los síntomas de la menopausia, aumentar la fertilidad, como afrodisiaco, para tratar la disfun...

  16. Wicket spikes: a case-control study of a benign eletroencephalografic variant pattern "Wicket spikes": estudo de variante eletrográfica benigna

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    MARCUS SABRY AZAR BATISTA

    1999-09-01

    Full Text Available Wicket spikes (WS are a benign eletroencephalogram (EEG variant, seen mainly in adults, during somnolence, in the temporal regions, in many clinical situations. WS can appear in trains or isolatedly, sometimes being difficult to differentiate from epileptiform activity. We reviewed 2,000 EEG's, found 65 with WS (3.25% and compared them with 65 normal EEG without WS. There was statistically significant (SS association between WS and age over 33; adolescent age was correlated to absence of WS and age over 65, to the presence of WS; there was an inverse correlation between WS and epilepsy, related to differences in age; a SS association with cerebrovascular disorders disappeared after controlling for age; a SS correlation with headache was also related to age; female predominance was not SS. There was a great variety of clinical situation associated with WS. We conclude that WS are a inespecific normal variant of the EEG that is age-related.As Wicket spikes (WS são um padrão benigno, variante da normalidade do eletrencefalograma (EEG, vistas principalmente em adultos, durante a sonolência, nas regiões temporais, em situações clínicas variadas. WS aparecem em "trens" ou isoladamente, podendo ser difícil diferenciá-las de atividade epileptiforme. Nós revisamos 2.000 EEG e encontramos 65 com WS (3,25% e os comparamos a 65 EEG 's normais sem WS. Encontramos associação estatisticamente significante (ES entre WS e idade acima de 33 anos; adolescência e ausência de WS e idade acima de 65 e presença de WS. Houve correlação inversa entre WS e epilepsia, explicada por diferenças nas médias de idade. A correlação ES entre WS e doença cerebrovascular desapareceu após controlarmos a idade. A correlação ES a cefaléia dependeu de sua relação à idade. A predominância do sexo feminino não foi ES. Houve maior variedade de situações clínicas associadas a WS. WS são uma variante normal do EEG, idade-relacionada.

  17. Extirpación de lesiones epiteliales benignas en la lengua, durante el periodo de gestación. Reporte de dos casos

    OpenAIRE

    Martínez de Páez, Norma A.; Bermúdez Rodríguez, José Rafael

    2009-01-01

    Las estructuras anatómicas que rodean la cavidad oral están cubiertas por una membrana formada por epitelio plano estratificado. El epitelio sirve de protección para los tejidos blandos orales y también de barrera para evitar el paso de factores patógenos externos. En la mucosa bucal pueden presentarse varios tipos de lesiones, unas de ellas conocidas en clínica como lesiones verrugosas–papilares, son de crecimiento exofítico benigno, las cuales pueden originarse en cualquier parte de la muco...

  18. Kıbrıs Mülkiyet Tartışmasına Taşınmaz Mal Komisyonu Açısından Bir Bakış Cyprus Property Dispute through the Glance of Immovable Property Commission

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    Derya ÖZVERİ

    2013-07-01

    erçevesindetanımlamak amaçlanmaktadır. Ardından Kıbrıs’ta Türk ve Yunantarafların mülkiyet tartışmasına bakış açılarını da ele alınacaktır. İkitarafında müzakare masasında çok esneme payı bırakmadıkları bubakış açıları birbirinden çok farklı bir yapı da olması, uzlaşınınoluşabilmesini olanaksızlaştırdığından bu argümanlar daha da önemkazanmaktadır. Anlaşmazlığın taraflardan biri olan Türk tarafi ikibölgelilik,Yunan tarafı ise insan hakları argümanları üzerinden konuyayaklaşmaktadır. Taraflar tezlerini bu yönde savunurken, bu çalışmaAvrupa Insan Haklari Mahkemesi´nin iki önemli karari ile (LoizidouTürkiye´ye Karşı ve Xenides-Arestis Türkiye‘ye Karsi kurulmasinasebebiyet verdiği ve kararları ile bir iç hukuk yontemi olaraktüketilmesini ön-kosul olarak gösterdiği Tasinmaz Mal Komisyonu´nuincelemeye çalışacak ve artık görüşme masasında kemikleşmiş bir konuhaline gelmiş, adanın mülkiyet sorununa yeni bir umut ışığıolabileceğini tartışmayı amaçlamaktadır.

  19. Tratamiento quirúrgico de una fractura trimaleolar de tobillo diagnosticada a las seis semanas de la lesión

    OpenAIRE

    Truffin Rodriguez, Yaniel; Gámez Arregoitía, Rafael; Pérez Martínez, Osmany

    2015-01-01

    El diagnóstico precoz de una lesión traumática modifica considerablemente la posible evolución del paciente. La articulación del tobillo no está ajena a dicha afirmación y la demora en el tratamiento de sus lesiones puede obstaculizar su correcta función. Por tales razones se presenta el caso de un paciente de 29 años de edad, de procedencia rural, con antecedentes de salud anterior, valorado en el Hospital Provincial Dr. Gustavo Aldereguía Lima de Cienfuegos. Refirió haber sufrido una caída ...

  20. Asociación entre predictores de coledocolitiasis diagnosticada por colangiografía intraoperatoria en el Hospital Nacional Arzobispo Loayza

    OpenAIRE

    Abuhadba Rodriguez, Nayib Elias

    2016-01-01

    Colelitiasis una de las patologías más comunes que condiciona tratamiento quirúrgico, tiene alta prevalencia en nuestro medio; gran número de pacientes pueden presentar coledocolitiasis no sospechada. El diagnóstico de coledocolitiasis, complicación más frecuente de la litiasis vesicular, es un desafío constante para el cirujano. Se requiere revisar adecuadamente la clínica y exámenes auxiliares. Se plantea la colangiografía intraoperatoria selectiva, como la prueba más accesible y menos dañi...

  1. Prevalencia de enfermedad cardiovascular en personas recién diagnosticadas de diabetes mellitus tipo 2 Cardiovascular disease prevalence in recent diagnosed type 2 diabetic patients

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    Manuel Mata-Cases

    2009-04-01

    Full Text Available Objetivo: Conocer la prevalencia de la enfermedad cardiovascular en el momento del diagnóstico de la diabetes mellitus tipo 2. Métodos: Estudio observacional retrospectivo realizado en un centro de atención primaria urbano entre 1991 y 2000. Revisión de las características clínicas, factores de riesgo y enfermedad cardiovascular el año del diagnóstico de diabetes. Se excluyeron los pacientes sin glucemias previas al diagnóstico. Se realizó un análisis de regresión logística para identificar las variables asociadas a la presencia de eventos cardiovasculares. Resultados: De los 598 nuevos casos de diabetes diagnosticados se analizaron los 487 que tenían valores previos de glucemia (media de edad [desviación estándar]: 60,4 [10,9] años; un 53% eran mujeres. La prevalencia de factores de riesgo cardiovascular fue: obesidad 61,1%, hipertensión arterial 71,9%, hipercolesterolemia 52%, hipertrigliceridemia 35,3% y tabaquismo actual 24% o previo 16,6%. El 96,9% tenía algún factor de riesgo cardiovascular y el 53,4% tres o más. Un total de 78 pacientes presentaron enfermedad cardiovascular anterior o detectada durante el primer año de diagnóstico (16%; intervalo de confianza del 95%[IC95%]: 12,8-19,3; varones 21,4% y mujeres 11,2%. La prevalencia de enfermedad cardiovascular aumentó con el número de factores de riesgo cardiovascular. El análisis de regresión logística mostró una asociación de la enfermedad cardiovascular y la edad >55 años (odds ratio [OR]=2,91; IC95%: 1,46-5,80, el tabaquismo (OR=2,28; IC95%: 1,15-4,51 y los valores de hemoglobina glucosilada (HbA1c >7% (OR=1,85; IC95%: 1,10-3,1. Conclusiones: Se observa una elevada prevalencia de factores de riesgo y enfermedad cardiovascular en el momento del diagnóstico de la diabetes; la edad, el tabaquismo y la HbA1c son las variables relacionadas con la enfermedad cardiovascular.Objective: To determine the prevalence of cardiovascular disease at diagnosis of type 2 diabetes mellitus. Methods: Retrospective observational study in an urban primary health care centre between 1991 and 2000. Review of clinical patient characteristics, cardiovascular disease and risk factors, in the year of diabetes diagnosis. Patients without any glycaemia recorded before diagnostic were excluded. Logistic regression was done to identify the variables associated to cardiovascular events. Results: From 598 cases of diabetes diagnosed, 487 with previous glycaemia were included for the analysis (mean age [SD], 60.4 [10.9]; 53% women. The prevalence of cardiovascular risk factors was: obesity 61.1%, hypertension 71.9%, hypercholesterolemia 52%, hypertriglyceridemia 35.3% and present or previous smoking habit (24 and 16,6%. 96.9% of them presented at least one of the studied cardiovascular risk factors and 53.4% three or more. 78 patients (16%; CI95%: 12.8-19.3 had cardiovascular disease before or during the first year of diagnosis (men 21.4% and women 11.2%. The prevalence of cardiovascular disease increased progressively with the number of cardiovascular risk factors. The significant predictive variables of cardiovascular disease (logistic regression were: age >55 years (OR=2.91; CI95%: 1.46-5.80, smoking habit (OR=2.28; CI95%: 1.15-4.51 and HbA1c >7% (OR=1.8; CI95%: 1.1-3.1. Conclusions: A high prevalence of cardiovascular disease and cardiovascular risk factors at diabetes diagnosis was observed. Age, smoking habit and elevated glycated haemoglobin were the variables related to cardiovascular disease.

  2. Avaliação de lâminas de colpocitologia oncótica previamente diagnosticadas como ASCUS: comparação interensaio e interobservadores

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    Souza José Helvécio Kalil de

    2004-01-01

    Full Text Available OBJETIVO: avaliar a existência de discordância intra e intercitopatologistas nas análises de lâminas de colpocitologias oncóticas que haviam recebido previamente o diagnóstico de células epidermóides atípicas de significado indeterminado (ASCUS e o grau dessa discordância. MÉTODOS: estudo transversal no qual foram analisadas 50 lâminas de colpocitologias oncóticas coletadas no mês de novembro de 2000 no município de Contagem e com diagnóstico prévio de ASCUS. Elas foram analisadas e classificadas por quatro citopatologistas, de acordo com as alterações propostas na primeira revisão de Bethesda, em 1991 (normal, alteração atrófica, alteração inflamatória, sugestiva de lesão de baixo grau, sugestiva de lesão de alto grau, sugestiva de carcinoma invasor, outros. Após a primeira análise, as lâminas foram novamente numeradas, de maneira aleatória, e entregues aos mesmos citopatologistas para novo exame. Foi utilizado o teste de kappa e sua especificação pontual, o kappa ponderado, para análises dos resultados. RESULTADOS: observaram-se graus bastante distantes de concordância entre diferentes análises do mesmo citopatologista, variando de 7,8 a 74,4%, (teste kappa. Quando foi instituído um peso para cada grau de discordância, os valores desse teste se elevaram, passando de 16,1% para o citopatologista A a 81,08% para o citopatologista B. Em relação às análises comparativas realizadas entre observadores distintos, os valores obtidos foram de 50,6% para o kappa e 63,4% para a sua variação pontual. CONCLUSÕES: a presente avaliação confirma a existência de subjetividade nos laudos citopatológicos de ASCUS, além de critérios imprecisos empregados pelo mesmo observador para obtenção desses resultados.

  3. Levels of specific prostatic antigen and osseous metastases diagnosed by gammagraphy; Niveles de antigeno prostatico especifico y metastasis oseas diagnosticadas por gamagrafia

    Energy Technology Data Exchange (ETDEWEB)

    Benitez C, V

    2003-07-01

    The bony gammagraphy with {sup 99}Tc - methylene-di phosphonates is the diagnostic method, suitable for the one study so much of the lesions wicked (primaries or metastatic) as benign; It is the test of election for the early detection of lesions bony metastatic to classify the patients in advanced illness, in the classification TNM and answer to treatment for prostate cancer. The recognition of the most frequent patterns in metastasis helps to establish the bony metastases diagnosis, differentiating them of normal variants or benign pathologies. The one classic pattern that has the biggest certainty diagnoses in the presence of multiple hot areas in the column, pelvis and ribs. The gammagraphy provides information on the localization and extension of the illness, the localization of the metastases is correlated with the progression of the one prostatic cancer, that which helps to establish the prognostic. An advanced gamma graphic pattern of the illness is the image of super scan that translates the understanding increased of the radiopharmaceutical by almost the whole skeleton with a poor elimination for via renal and that habitually is even observed with other leisure less advanced of the illness. (Author)

  4. Enfermedad celiaca materna no diagnosticada y riesgo de tener hijos con bajo peso al nacimiento Maternal non-diagnosed celiac disease and risk of low birth weight

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    G. Solís Sánchez

    2008-06-01

    Full Text Available Objetivo: conocer la prevalencia de enfermedad celiaca en madres de neonatos mayores y menores de 2.500 gramos de peso al nacimiento. Pacientes: sujetos: casos: madres de neonatos menores de 2.500 g al nacimiento. Controles: madres de neonatos mayores de 2.500 g al nacimiento. Un control por cada caso. Instrumentalización: encuesta clínico-epidemiológica y serología celiaca. Métodos: estudio caso-control. Ámbito: mujeres del Área Sanitaria V (Gijón del Principado de Asturias que den a luz en el Hospital de Cabueñes. Resultados: se analizaron 1.103 mujeres: 577 madres de niños menores de 2.500 g y 526 madres de niños mayores de 2.500 g. Se diagnosticaron 4 casos de celiaquía, 2 en cada grupo. De las 4 madres, 3 dieron a luz a niños a término (1 caso cada 235 madres, prevalencia 0,42% y 1 dio a luz a un niño prematuro (1 caso cada 389 madres, prevalencia 0,26%. Dos madres dieron a luz a niños de peso adecuado para su edad gestacional (1/419 madres, prevalencia 0,24% y 2 madres dieron a luz niños de bajo peso para su edad gestacional (1/132 madres, prevalencia 0,75%. La odds ratio para peso menor de 2.500 g al nacimiento fue 0,91 (IC 95% 0,12-6,49, para prematuridad 0,61 (IC 95% 0,06-5,89 y para bajo peso para su edad gestacional 3,19 (0,44-22,79. Conclusiones: la prevalencia de enfermedad celiaca en mujeres fértiles de Gijón es de un caso cada 275 madres (prevalencia 0,36%, sin que hayamos encontrado diferencias entre los dos grupos estudiados.Aims: in order to know the prevalence of celiac disease in mothers with newborns weighing less or more than 2,500 g at birth we carried out a case-control study. Patients: mothers of newborns in Cabueñes Hospital. Case group: Mothers with babies weighing less than 2,500 g at birth. Controls: Mothers with babies weighing more than 2,500 g at birth. One control for each case. Methods: epidemiological and clinical interviews, and celiac disease serology. Results: we studied 1103 women: 577 cases and 526 controls. We diagnosed 4 celiac disease cases, 2 in the case group and 2 in the control group. These 4 mothers had 3 term newborns (1 case in each 235 mothers; prevalence 0.42% and 1 preterm newborn (1 case in each 389 mothers; prevalence 0.26%. Two cases had babies with adequate birth weight for their gestational age (1 case in each 419 mothers; prevalence 0.24% and two cases had babies with low birth weight for their gestational age (1 in each 132 mothers; prevalence 0.75%. The odds ratio for low birth weight was 0.91 (95% CI: 0.12-6.49, the odds ratio for preterm birth was 0.61 (95% CI: 0.06-5.89, ad the odds ratio for low birth weight for gestational age was 3.19 (95% CI: 0.44-22.79. Conclusions: the prevalence of celiac disease in fertile women in our geographic area was 0.36% (1 case in each 275 mothers, and no differences were found between study groups.

  5. Caracterización clinicoepidemiológica de pacientes con tuberculosis diagnosticada en el Hospital Provincial "Celia Sánchez Manduley"

    Directory of Open Access Journals (Sweden)

    Sahily Quintero Salcedo

    2014-06-01

    Full Text Available Se realizó un estudio descriptivo, retrospectivo y longitudinal de 63 pacientes con tuberculosis, atendidos en el Hospital Clinicoquirúrgico Docente Universitario "Celia Sánchez Manduley" de Manzanillo, provincia de Granma, desde el 2009 hasta el 2011, con vistas a caracterizarles según factores clinicoepidemiológicos de interés. Entre las variables analizadas figuraron: edad, sexo, procedencia, factores de riesgo, formas clínicas de la tuberculosis, tipo de tuberculosis extrapulmonares y categoría de casos. En la casuística predominaron el sexo masculino, los grupos etarios de 45-65 años, procedentes en su mayoría de zonas rurales; la ingestión de alcohol como factor de riesgo asociado y las formas pulmonares con baciloscopia positiva como las formas clínicas más frecuentes. La mayoría de los casos notificados fueron nuevos

  6. Entrevistando as famílias de recém-nascidos mal-formados como proposta de avaliação e de intervenção de enfermagem - DOI: 10.4025/actascihealthsci.v26i1.1646 Interviewing the families of sick newborn babies as a proposal of - DOI: 10.4025/actascihealthsci.v26i1.1646

    Directory of Open Access Journals (Sweden)

    Dirce Laplaca Viana

    2004-04-01

    Full Text Available Trata-se de um estudo que buscou meios para entender como lidar com a família que vivenciou a notícia de ter um recém-nascido mal-formado. A entrevista ocorreu em um hospital público de São Paulo, em novembro de 2002, utilizando-se o Modelo Calgary de Avaliação e Intervenção na Família (MCAF/MCIF. O estudo mostrou a necessidade de intervenções construídas com a família para minimizar o impacto da notícia e para favorecer espaço para expressão de sentimentos e resolução da crise. O papel do enfermeiro como membro da equipe interdisciplinar é tentar efetivar o trabalho de ajuda à família de forma precoce, quando esta vive a difícil experiência de ter uma criança especial. A intervenção visa atuar com a família a partir da detecção do problema, utilizando a escuta ativa da comunicação verbal e não-verbal na tentativa de compreensão da situação e atuar como facilitador do processo de resolutividade da crise vivenciada.This paper is based on a study that searched ways to understand how to deal with the family who experienced the news of a sick newborn. The interview was performed in a hospital located in São Paulo, Brazil, in November of 2002 and it used the Calgary Model of Assessment and Intervention in Family (CMAF/CMIF. This study showed the need for intervention with the family to minimize the impact of receiving the news of a sick newborn, and to provide support through a conversation for resolution of the problem. The function of the nurse is to try to perform a precocious work with the family, facing the difficult experience of having a special child. The intervention aims to help the family to solve the problem, listening to the verbal and not verbal communication, searching to understand the situation with the family.

  7. Amaç ve Beklenti Karşısında Karşılaştırmalı Edebiyatın Tanı(MSal Krizine İlişkin Birtakım Tartışmalı Saptamalar Some Argumentative Determinations Regarding Diagnostic/Definitional Crisis Of Comparative Literature In Terms Of Accordance With Its Purpose And Expectation

    Directory of Open Access Journals (Sweden)

    Abdulhakim TUĞLUK

    2013-09-01

    Full Text Available Comparison which possesses the characteristics of critic in linewith its purposes and ambitions keeps on its actuality and differenceperception because of its argumentative position within the science ofliterature. “Comparative Literature Science” which has become effectivein literature argumentations in recent years in Turkey has not beenable to make its identity and conceptual entity acceptable, yet. Not onlythe uncertainties in the definition, but also some problems in practicekeep the questions against comparative literature in a certain level.There are also some uncertainties whether it is a method or a science initself as well as the acceptability of it by national men of literature.Comparison, which is seen as easy to do at first in terms of feasibility,shows itself as a complex process when the literal and aestheticmissions attributed by the concept to it are taken into consideration.This complexity becomes a crisis in which there are many questionswhen it is faced with diagnostic and definitive problems. On the otherhand, West-centered perception of the comparative literature and itsinternational face embracing the concept of „world literature‟(Weltliteratur make global scale expectations committed by the conceptmore argumentative rather than meeting these expectations. In thisstudy, the main starting point is gaining a certain point of view to theidentity confusion of comparative literature and establishing a generalargumentation basis. The purpose of this study is revealing somecomplex points in theory and practice considering existential problemsof comparative literature and bringing some expansion to somehandicaps regarding essence of the comparative literature. Amaç ve hedefleri doğrultusunda bir eleştiri türü niteliği taşıyan karşılaştırma, edebiyat bilimi içerisindeki tartışmalı konumu nedeniyle güncelliğini ve farklılık algısını sürdürmektedir. Türkiye‟de, son yıllarda, edebi tart

  8. Survival of a cohort of women with cervical cancer diagnosed in a Brazilian cancer center Sobrevida de mujeres con cáncer de cuello uterino diagnosticadas en un centro brasileño Sobrevida de mulheres com câncer de colo uterino diagnosticadas em um centro brasileiro

    Directory of Open Access Journals (Sweden)

    Claudio Calazan do Carmo

    2011-08-01

    Full Text Available OBJECTIVE: To assess overall survival of women with cervical cancer and describe prognostic factors associated. METHODS: A total of 3,341 cases of invasive cervical cancer diagnosed at the Brazilian Cancer Institute, Rio de Janeiro, southeastern Brazil, between 1999 and 2004 were selected. Clinical and pathological characteristics and follow-up data were collected. There were performed a survival analysis using Kaplan-Meier curves and a multivariate analysis through Cox model. RESULTS: Of all cases analyzed, 68.3% had locally advanced disease at the time of diagnosis. The 5-year overall survival was 48%. After multivariate analysis, tumor staging at diagnosis was the single variable significantly associated with prognosis (pOBJETIVO: Evaluar la sobrevida global de mujeres con cáncer de cuello uterino e identificar factores pronósticos relacionados. MÉTODOS: Todos los 3.341 casos tratados en el Instituto Nacional de Cáncer, Rio de Janeiro, Sureste de Brasil, entre 1999 y 2004 fueron seleccionados y sus datos clínicos, anatomo-patológicos y de seguimiento fueron colectados. Se utilizaron la curva de Kaplan-meier y el modelo de Cox par evaluación de la sobrevida y para análisis logística múltiple, respectivamente. RESULTADOS: De los casos estudiados, 68,3% presentaban enfermedad localmente avanzada. La sobrevida en cinco años fue de 48%. Posterior al análisis múltiple, el estadio clínico al diagnóstico fue la única variable significativamente asociada con el pronóstico (pOBJETIVO: Avaliar a sobrevida global de mulheres com câncer de colo uterino e identificar fatores prognósticos relacionados. MÉTODOS: Todos os 3.341 casos tratados no Instituto Nacional de Câncer, Rio de Janeiro, RJ, entre 1999 e 2004 foram selecionados e seus dados clínicos, anatomo-patológicos e de seguimento foram coletados. Foram utilizados a curva de Kaplan-Meier e o modelo de Cox para avaliação da sobrevida e para análise logística múltipla, respectivamente. RESULTADOS: Dos casos estudados, 68,3% apresentavam doença localmente avançada. A sobrevida global em cinco anos foi de 48%. Após análise múltipla, o estádio clínico ao diagnóstico foi a única variável significativamente associada com o prognóstico (p<0,001. Mortalidade e o estádio clínico da doença apresentaram efeito dose-resposta, variando de 27,8 por 1.000 casos-ano a 749,6 por 1.000 casos-ano em mulheres com estádio I e IV, respectivamente. CONCLUSÕES: Os resultados mostram que a detecção precoce por meio de programas de prevenção é fundamental para aumentar a sobrevida em câncer cervical.

  9. Nevus sebáceo de Jadassohn: descripción de 261 casos y su asociación con otros tumores

    Directory of Open Access Journals (Sweden)

    Paula Andrea Arango Pérez

    2008-11-01

    Full Text Available El nevus sebáceo de Jadassohn (NSJ es una lesión congénita benigna pero por decenios se la consideró con alto potencial de malignización hacia el carcinoma basocelular (CBC, por lo que se sugería su resección precoz. Series recientes han establecido que muchas de las neoplasias diagnosticadas como malignas eran benignas. Nuestra revisión de 261 casos constituye un aporte al conocimiento del NSJ. Hasta ahora no ha habido series similares en Colombia, y en América Latina las publicaciones no superan los 60 pacientes. MATERIALES Y MÉTODOS: se analizaron 261 casos del archivo de histopatología de la Facultad de Medicina de la Universidad de Antioquia con diagnóstico de NSJ entre 1976 y 2008, incluyendo biopsias y resecciones. RESULTADOS: de los 261 pacientes, 143 eran hombres (54,8% y 118 mujeres (45,2%; la edad promedio fue de 17,4 años; el NSJ estaba presente al nacimiento en el 90,4%. La localización más frecuente fue en el cuero cabelludo (62,5%. Presentaron tumores asociados 28 pacientes: siringocistadenoma papilífero (SCAP 8 casos (3,1%, tumor del infundíbulo folicular (TIF 5 casos (1,9%. Cuatro casos fueron de CBC (1,5% con edad promedio de 40,7 años. Cuatro de 7 tumores diagnosticados previamente como CBC, fueron reclasificados como TIF. DISCUSIÓN: el SCAP fue el tumor más frecuentemente asociado, tal como aparece reportado por otros autores. En esta serie se encontró el TIF con una mayor frecuencia que en la literatura revisada. El CBC fue el único tumor maligno y se presentó solo en adultos. Los resultados de esta serie evidencian un comportamiento benigno del NSJ, por lo que se debiera replantear la necesidad de resección precoz. La revisión histológica del diagnóstico inicial demuestra que lesiones benignas pueden ser confundidas fácilmente con CBC, sobreestimando el potencial maligno de este hamartoma.

  10. Uma revisão sobre depressão como fator de risco na Doença de Parkinson e seu impacto na cognição Revisión sobre la depressión como factor de riesgo en el Mal de Parkinson e impacto sobre la cognición A review of depression as a risk factor in Parkinson's disease and the impact on cognition

    Directory of Open Access Journals (Sweden)

    Cláudia Débora Silberman

    2004-04-01

    utilizem critérios diagnósticos definidos e com amostras representativas da população podem trazer esclarecimento sobre o assunto.OBJETIVOS: Este trabajo tiene dos objetivos: 1 Examinar el impacto de la depresión sobre la cognición en el Mal de Parkinson (MP. 2 Examinar el papel de la depresión como factor de riesgo tanto para el MP como para trastorno cognoscitivo en el MP. METODOLOGÍA: Revisión de la literatura internacional (Medline, de artículos clínicos, seccionales, prospectivos y de caso control evaluando la función cognoscitiva de Parkinsonianos con y sin depresión, entre 1967 y 2003. Palabras clave: Mal de Parkinson, Depresión y Cognición. RESULTADOS: Los trabajos sobre el impacto de la depresión en la cognición de parkinsonianos presentan afirmaciones divergentes. Cinco artículos concluyen que hay impacto e cuatro no confirman esos datos. Puede afirmarse que la depresión es un factor de riesgos para MP así como el MP es un factor de riesgo para la depresión. No en tanto, ninguna definición fue posible en lo que se refiere a la depresión como factor de riesgo para trastornos cognoscitivos en parkinsonianos. Se observa que los datos sobre a prevalencia de la depresión y déficit cognoscitivo en el MP son inconclusivos con grande margen porcentual entre los autores. La depresión en parkinsonianos está asociada con el avance de la gravedad del MP, estado avanzado de Hoehn y Yahr, puntuación alta en la Unified Parkinson's Disease Rating Scale (UPDRS ocurrencia de caídas, baja puntuación en el Mini Examen del Estado Mental (MEEM y en la escala de Schwab y England, déficit cognoscitivo, bradykinesia axial, alteraciones en el caminar y en el balance, edad más avanzada, sexo femenino y presencia de alteración del pensamiento. CONCLUSIÓN: La interacción entre la depresión y MP es compleja y bi-direccional. La depresión es un factor de riesgo para MP así como MP es un factor de riesgo para la depresión. Es imposible trazar un perfil mas

  11. Mal du siècle et mal du lieu : bovarysme et romantisme mêlés dans les deux grands romans modernes de Flaubert

    Directory of Open Access Journals (Sweden)

    Philippe Chardin

    2010-01-01

    Full Text Available Cet article tente, à partir d’une comparaison d’ensemble entre les deux grands romans modernes de Flaubert, Madame Bovary et L’Éducation sentimentale, et d’une superposition d’exemples significatifs empruntés à chacun d’eux, de montrer que la série des contrastes qui viennent tout de suite à l’esprit ne doit pas dissimuler des variations subtiles autour des mêmes schémas narratifs et des mêmes paysages psychiques : aussi bien pour ce qui est du pôle négatif des ridicules (« bovarysme » impénitent de Frédéric et des infortunes (analogies entre les épreuves traversées, notamment en matière d’« éducation sentimentale » que pour ce qui est du pôle du positif — plus implicite chez Flaubert — incluant une sorte de principe de réhabilitation partielle des « premiers plans » et la permanence de tout un romantisme de la singularité, de la révolte, de l’élection par le malheur, de la passion, du désir.With a global comparison between Flaubert’s two chief modern novels, Madame Bovary and L’Éducation sentimentale, and a superposition of suggestive examples taken from both of them, this article intends to prove that the sequence of contrasts that firstly appear must not conceal the subtle variations on the same narrative patterns and the same psychological climates. We can notice this phenomena as well as for the negative poles of ridiculous features (Frederic’s impenitent “bovarysme” and misfortunes (analogies between the trials that have to be faced by the heroes — especially those of the “sentimental journey”, as for the positive pole — more implicit in Flaubert’s prose — that implies a kind of partial rehabilitation principle of the main characters, and the persistence of romanticism, a whole romanticism with singularity, revolt, election through unhappiness,  passion and desire.

  12. Congenital dermoid inclusion cyst over the anterior fontanel: report of three cases Cisto dermóide de inclusão congênita sobre a fontanela anterior: relato de três casos

    Directory of Open Access Journals (Sweden)

    Humberto Belem de Aquino

    2003-06-01

    Full Text Available Congenital dermoid inclusion cyst over the anterior fontanel (CDIC is an uncommon cystic lesion located over the anterior fontanel. It is a benign and curative lesion and most of the time, can be diagnosed at birth. From 1994 to 2001, three patients were operated with this kind of lesion and after reviewing the literature we found 229 cases and only 6 cases described in Brazil. Our objective in this study is to report three more cases.Cisto dermóide de inclusão congênita sobre a fontanela anterior (CDIC é lesão rara localizada na região da fontanela anterior. Trata-se de lesão benigna e curável que, na maioria das vezes, é diagnosticada no nascimento. De 1994 a 2001, três pacientes foram operados com este tipo de lesão e, através dos dados disponíveis na literatura, verificamos somente 229 casos descritos, apenas 6 descritos no Brasil, o que nos motivou a registrar mais três casos.

  13. Impacto da necropsia na definição da infecção fúngica e avaliação epidemiológica

    OpenAIRE

    Elisabeth Pereira Lopes, Nadja

    2010-01-01

    O resultado de óbitos mal-definidos torna indispensável à necropsia para que seja elucidada a causa morte. Dessa forma, este estudo visou verificar infecções fúngicas isoladas ou em associação com outras doenças relacionadas ao óbito, bem como dados epidemiológicos que possam ter contribuído. Durante a necropsia, foram realizados exames micológicos e histopatológicos. Os órgãos acometidos por fungos foram pulmões, cérebro, rim, meninges, fígado e coração, sendo diagnosticadas p...

  14. Jeanne and Charles : Les Fleurs du Mal as ‘Uncertain Fables’

    NARCIS (Netherlands)

    Rosello, M.

    2017-01-01

    This article explores the constantly evolving status of “Jeanne Duval” within the various discourses that constitute French studies. Travelling back and forth between invisibility and hyper-visibility, legibility and opacity, at times relegated to the margins of Baudelaire’s poetry, and sometimes

  15. 2558-IJBCS-Article-Amadou Malé Kouyaté

    African Journals Online (AJOL)

    admin

    The native oil tree species: a useful resource for local communities in southern Mali ... understand the uses of oil trees species according to the ethnic group, village, age and gender. Semi- ..... among parkland agroforests in eastern. Niger. ... for the benefit of the poor, Washington,. USA. ... India's Dry Deciduous Forest.

  16. Local perceptions of climate change impacts and migration patterns in Malé, Maldives

    Czech Academy of Sciences Publication Activity Database

    Stojanov, R.; Duží, Barbora; Kelman, I.; Němec, D.; Procházka, D.

    2017-01-01

    Roč. 183, č. 4 (2017), s. 370-385 ISSN 0016-7398 Institutional support: RVO:68145535 Keywords : Maldives * climate change impacts * migration * risk management * quantitative survey Subject RIV: DE - Earth Magnetism, Geodesy, Geography OBOR OECD: Cultural and economic geography Impact factor: 3.132, year: 2016 http://onlinelibrary.wiley.com/doi/10.1111/geoj.12177/abstract

  17. Assessment of Evapotranspiration Simulation in the Malše Basin

    Czech Academy of Sciences Publication Activity Database

    Košková, Romana; Němečková, Soňa

    2009-01-01

    Roč. 4, Sp. Iss. 2 (2009), s. 111-122 ISSN 1801-5395 R&D Projects: GA AV ČR(CZ) KJB300600602 Institutional research plan: CEZ:AV0Z20600510 Keywords : hydrological modelling * evapotranspiration * SWIM model Subject RIV: DA - Hydrology ; Limnology

  18. Adaptace pracovníků v malé organizaci

    OpenAIRE

    Štěpánová, Berta

    2012-01-01

    Dissertation deals with an analysis of an adaptation process in a small organization. It handles placing of the adaptation process into a context of human resources activities. Individual areas of the adaptation are specified - working adaptation, social adaptation and adaptation to a company culture. Also aims of the adaptation, factors influencing the process of adaptation in the company, planning and management of the adaptation are specified. The process of adaptation, elements and tools ...

  19. Effect of refrigerant mal-distribution in fin-and-tube evaporators on system performance

    DEFF Research Database (Denmark)

    Kærn, Martin Ryhl; Elmegaard, Brian; Larsen, Lars Finn Sloth

    2009-01-01

    the condenser is a dynamic moving boundary model. The evaporator model is a dynamic distributed one-dimensional homogeneous equilibrium model, in order to capture the distribution phenomena. Fin-and-tube heat exchangers usually have a complex circuitry, however the evaporator will be simplified to be two...

  20. Fugacities and Inanities in Malú Urreola’s "Nada" y "Bracea".

    Directory of Open Access Journals (Sweden)

    Gonzalo Ignacio Rojas

    2017-07-01

    Full Text Available This paper aims to analyze the last two textbooks from Malu Urriola: Nada y Bracea, which are part of a trilogy to be constructed. For this purpose, we reviewed both theoretical and anchor text from the rhizome (Deleuze and Guattari and the concept of differance (Derrida to see the poetic discourse as an agent for representation of the poetic word in another, besides the Blend aesthetic notions as the perky, rebound, transience and intermediate. These anchorages and mixtures are placed in tension in this trilogy to be done and thus respond to the crossing that occur in these textbooks between poetic expression and its inanity as representing the speaking being.

  1. Genómica del Trypanosoma cruzi. Nuevas oportunidades para tratar el mal de Chagas

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    Jorge A. Huete-Pérez

    2006-12-01

    Full Text Available LA SECUENCIACIÓN DEL GENOMA HUMANO PUBLICADA EN FEBRERO de 2001 ha sido considerada como el hito científico más importante del siglo XX. La secuenciación, cuatro años más tarde, de tres parásitos tripanosmatidas, entre ellos el Trypanosoma cruzi, podría ser también catalogada como uno de los acontecimientos científicos más importantes para la salud publica del continente americano. Aquí se presenta un panorama general sobre los resultados más significativos del estudio geonómico del T. cruzi, se abordan los trabajos realizados por nuestro laboratorio en la Universidad Centroamericana, finalizando con una discusión sobre las perspectivas del uso de la genómica en Nicaragua.

  2. Studie proveditelnosti podnikání malé maloobchodní firmy

    OpenAIRE

    Drugda, Marek

    2009-01-01

    This thesis describes the individual aspects of retail entrepreneurship of a small enterprise using the knowledge of large retail entrepreneurs. It introduces the business strategy of a clothing retail shop in Prague with an innovative business model, evaluates the external environment of the enterprise and its influence on the industry, outlines the procedures for managing specific areas of the operation and evaluates the feasibility of the enterprise utilizing a break even analysis and a ca...

  3. MalWebID-Autodetection and Identification of Malicious Web Hosts Through Live Traffic Analysis

    Science.gov (United States)

    2013-03-01

    site (i.e., Porn , Rx/Pharmaceutical, illegal activity, etc.) – propagate or contain viruses, spyware, or other harmful programs, participate in spamming...abu- sive sites remain a constant problem. This thesis explores a technique to discern hosts that support abusive web infrastructure by discovering...in- clude, but is not limited to, web sites that cater to, sponsor, or actively participate in supporting various forms of malicious content. Thus

  4. Strategi Marketing Mix Baitul Mal Wa Tamwil (BMT) Unit Gabungan Terpadu (UGT) Sidogiri Pasuruan

    OpenAIRE

    Kirom, Cihwanul

    2016-01-01

    Within the business realm, marketing is a key factor which determines the success of distribution. Therefore, strategy and innovation are a necessity. Marketing activity would ensure whether a certain product is delivered to the costumers. In order to achieve the desired goals of marketing, it is important to manufacturers to follow a set of marketing processes, which comprise market overview, marketing strategy, marketing mix, and evaluation. Marketing mix is a set of strategies consist of p...

  5. Rozvoj kultury v malé obci Středočeského kraje

    Czech Academy of Sciences Publication Activity Database

    Vojtíšková, Kateřina

    2013-01-01

    Roč. 5, č. 2 (2013), s. 143-160 E-ISSN 1803-8220 R&D Projects: GA MK DF11P01OVV032 Keywords : local culture * regional development * citizen participation Subject RIV: AE - Management ; Administration http://acpo.vedeckecasopisy.cz/publicFiles/00462.pdf

  6. Ganándole la batalla al mal humor. Una propuesta didáctica

    Directory of Open Access Journals (Sweden)

    Sarah Díaz García

    2012-01-01

    Full Text Available En los últimos años, el aprendizaje de lenguas extranjeras ha llegado a ser una necesidad real tanto profesional como personal para todos nosotros como ciudadanos y como trabajadores. La enseñanza del español como lengua extranjera, que es el área de estudio en el que nos centraremos en el resto del presente artículo, ha evolucionado a medida que nuestra sociedad ha ido cambiando y adaptándose a los nuevos tiempos. Este cambio surgió con el Marco Común Europeo de Referencia para las Lenguas (MCER; pasamos de darle una máxima importancia a los aspectos puramente lingüísticos a abrirnos al hecho de que aprender un segundo idioma no es solo centrarnos en la gramática. La competencia comunicativa, por ejemplo, ha ido cobrando protagonismo en los últimos años; la idea de que un estudiante solo es competente en el uso de una lengua cuando utiliza la lingüística (pensemos en la gramática de forma correcta y siguiendo la norma ha caído en desaprobación para muchos. La realidad es que para que un alumno se considere competente en el uso de otra lengua que no sea la suya debe saber utilizar las técnicas y recursos pertinentes para poder comunicarse efectivamente con su interlocutor en un contexto real de habla.

  7. Ganándole la batalla al mal humor. Una propuesta didáctica

    Directory of Open Access Journals (Sweden)

    Sarah Díaz García

    2012-08-01

    Full Text Available En los últimos años, el aprendizaje de lenguas extranjeras ha llegado a ser una necesidad real tanto profesional como personal para todos nosotros como ciudadanos y como trabajadores. La enseñanza del español como lengua extranjera, que es el área de estudio en el que nos centraremos en el resto del presente artículo, ha evolucionado a medida que nuestra sociedad ha ido cambiando y adaptándose a los nuevos tiempos. Este cambio surgió con el Marco Común Europeo de Referencia para las Lenguas (MCER;[1] pasamos de darle una máxima importancia a los aspectos puramente lingüísticos a abrirnos al hecho de que aprender un segundo idioma no es solo centrarnos en la gramática. La competencia comunicativa, por ejemplo, ha ido cobrando protagonismo en los últimos años; la idea de que un estudiante solo es competente en el uso de una lengua cuando utiliza la lingüística (pensemos en la gramática de forma correcta y siguiendo la norma ha caído en desaprobación para muchos. La realidad es que para que un alumno se considere competente en el uso de otra lengua que no sea la suya debe saber utilizar las técnicas y recursos pertinentes para poder comunicarse efectivamente con su interlocutor en un contexto real de habla. [1] El Marco Común Europeo de Referencia para las Lenguas surgía en el año 2001. Desde entonces la enseñanza y el aprendizaje de lenguas extranjeras dio un cambio radical respecto a la metodología y la evaluación.

  8. ‘Copiar y pegar’ en investigaciones en el pregrado: haciendo mal uso del Internet

    Directory of Open Access Journals (Sweden)

    Charles Huamaní

    2008-06-01

    Full Text Available Introducción: La ética en el proceso de investigación es un tema poco abordado durante el pregrado, por lo que debe ser analizada para prevenir infracciones que podrían afectar el desarrollo de todo investigador en formación. Objetivo: Determinar las características de copia en los trabajos de investigación realizados durante el pregrado, por estudiantes de Medicina Humana de segundo año. Diseño: Estudio observacional retrospectivo. Lugar: Facultad de Medicina, Universidad Nacional Mayor de San Marcos. Población: la sección de la ‘introducción’ de trabajos de investigación realizados el año 2004 en un curso curricular. Intervenciones: se revisó manualmente las oraciones de la ‘introducción’ de los trabajos, se describen el tipo de copia, el número de trabajos, autores, asesores, párrafos copiados, y el tipo de fuentes de información y de copia. Principales medidas de resultados: frecuencias y porcentajes de oraciones copiadas y tipo de copia. Resultados: Se revisó un total de 24 trabajos de investigación, con un promedio de 6 autores y 2 asesores por trabajo, 23 tenían alguna evidencia de copia electrónica, 8 sólo tenían copia literal; del total de oraciones evaluadas, el 64% corresponde a copia total de oraciones; sólo el 30% de las fuentes copiadas eran publicaciones científicas en línea, el resto son fuentes de acceso público no especializadas. Conclusiones: se describe una alta frecuencia de copia en investigaciones durante el pregrado provenientes de fuentes electrónicas, por lo que es necesario prevenir que se repita en futuras investigaciones al implementar sistemas de búsqueda sistemática de plagio.

  9. Metabolismo do ácido fólico na malária

    Directory of Open Access Journals (Sweden)

    Aymoré Vaz Pinto

    1983-06-01

    Full Text Available O estudo de 27 pacientes infectados pelo Plasmodium falciparum comparado com pessoas aparentemente sadias mostra: a diminuição do folato no soro dos pacientes infectados; b diminuição do folato sêrico nos primeiros 8 dias que seguiram ao tratamento, interpretados como sendo devido à mobilização pela eritropoiese compensadora; c folato eritrocítico normal.

  10. Rotavirus Infection and Disease in a Multisite Birth Cohort: Results From the MAL-ED Study.

    Science.gov (United States)

    Mohan, Venkata Raghava; Karthikeyan, Ramanujam; Babji, Sudhir; McGrath, Monica; Shrestha, Sanjaya; Shrestha, Jasmin; Mdumah, Estomih; Amour, Caroline; Samie, Amidou; Nyathi, Emanuel; Haque, Rashidul; Qureshi, Shahida; Yori, Pablo Peñataro; Lima, Aldo A M; Bodhidatta, Ladaporn; Svensen, Erling; Bessong, Pascal; Ahmed, Tahmeed; Seidman, Jessica C; Zaidi, Anita K M; Kosek, Margaret N; Guerrant, Richard L; Gratz, Jean; Platts-Mills, James A; Lang, Dennis R; Gottlieb, Michael; Houpt, Eric R; Kang, Gagandeep

    2017-08-01

    In a multicountry birth cohort study, we describe rotavirus infection in the first 2 years of life in sites with and without rotavirus vaccination programs. Children were recruited by 17 days of age and followed to 24 months with collection of monthly surveillance and diarrheal stools. Data on sociodemographics, feeding, and illness were collected at defined intervals. Stools were tested for rotavirus and sera for antirotavirus immunoglobulins by enzyme immunoassays. A total of 1737 children contributed 22646 surveillance and 7440 diarrheal specimens. Overall, rotavirus was detected in 5.5% (408/7440) of diarrheal stools, and 344 (19.8%) children ever had rotavirus gastroenteritis. Household overcrowding and a high pathogen load were consistent risk factors for infection and disease. Three prior infections conferred 74% (P < .001) protection against subsequent infection in sites not using vaccine. In Peru, incidence of rotavirus disease was relatively higher during the second year of life despite high vaccination coverage. Rotavirus infection and disease were common, but with significant heterogeneity by site. Protection by vaccination may not be sustained in the second year of life in settings with high burdens of transmission and poor response to oral vaccines. © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

  11. Mal-Netminer: Malware Classification Approach Based on Social Network Analysis of System Call Graph

    Directory of Open Access Journals (Sweden)

    Jae-wook Jang

    2015-01-01

    Full Text Available As the security landscape evolves over time, where thousands of species of malicious codes are seen every day, antivirus vendors strive to detect and classify malware families for efficient and effective responses against malware campaigns. To enrich this effort and by capitalizing on ideas from the social network analysis domain, we build a tool that can help classify malware families using features driven from the graph structure of their system calls. To achieve that, we first construct a system call graph that consists of system calls found in the execution of the individual malware families. To explore distinguishing features of various malware species, we study social network properties as applied to the call graph, including the degree distribution, degree centrality, average distance, clustering coefficient, network density, and component ratio. We utilize features driven from those properties to build a classifier for malware families. Our experimental results show that “influence-based” graph metrics such as the degree centrality are effective for classifying malware, whereas the general structural metrics of malware are less effective for classifying malware. Our experiments demonstrate that the proposed system performs well in detecting and classifying malware families within each malware class with accuracy greater than 96%.

  12. Motivace pracovníků v malém podniku

    OpenAIRE

    Charvátová, Soňa

    2010-01-01

    This thesis is concerned with motivation and satisfaction of employees of one company in Prague. The theory is mainly focused on the explanation of motivation and stimulation, labour motivation and employee benefits. The point of the practical part is an analysis of the motivation system and employee satisfaction in the company. The resulting information is explicated. For the parts with the worst findings, some recommendations for improving the present motivation system are suggested.

  13. PERAN BAITUL MAL WAT TAMWIL UNTUK PEMULIHAN EKONOMI NASABAH KORBAN GEMPA DI GANTIWARNO KLATEN

    Directory of Open Access Journals (Sweden)

    Muhammad Sholahuddin

    2011-12-01

    Full Text Available The aims of this research are to get a clear description about the role, supporting factors and constraint factors of BMT “Surya” toward a societies empowerment in the agriculture sector in Klaten. Related with the aims of the research, therefore this this case study used qualitative research. Method of collecting the data used In Deep Interview throught three ways, those are observating, interviewing and documentating. Technique of analizing the data used Miles-Huberman.  The result of this research are: (1 The role of Baitul Maal Wat Tamwil (BMT “Surya” is empowerment of realized through services product by BMT “Surya” those are: (a loan of agriculture sector (b loan of livestock sector (c loan of service sector and (d loan of convection sector (2 supporting factors toward societies empowerment of economical sector in Klaten are: (a strategic area (b having closed emotional between the manager of BMT “Surya” and their clients, (c developing relatieves atmosphere event it’s still prioriting the professionalism (3 constraint factors toward societies empowerment of economical sector in Klaten are: (a They have only local network (b there is a clients who get stuck in the process of pay in installments (c pay in installments which is not appropriate with the loan.

  14. Household food access and child malnutrition: results from the eight-country MAL-ED study.

    Science.gov (United States)

    Psaki, Stephanie; Bhutta, Zulfiqar A; Ahmed, Tahmeed; Ahmed, Shamsir; Bessong, Pascal; Islam, Munirul; John, Sushil; Kosek, Margaret; Lima, Aldo; Nesamvuni, Cebisa; Shrestha, Prakash; Svensen, Erling; McGrath, Monica; Richard, Stephanie; Seidman, Jessica; Caulfield, Laura; Miller, Mark; Checkley, William

    2012-12-13

    Stunting results from decreased food intake, poor diet quality, and a high burden of early childhood infections, and contributes to significant morbidity and mortality worldwide. Although food insecurity is an important determinant of child nutrition, including stunting, development of universal measures has been challenging due to cumbersome nutritional questionnaires and concerns about lack of comparability across populations. We investigate the relationship between household food access, one component of food security, and indicators of nutritional status in early childhood across eight country sites. We administered a socioeconomic survey to 800 households in research sites in eight countries, including a recently validated nine-item food access insecurity questionnaire, and obtained anthropometric measurements from children aged 24 to 60 months. We used multivariable regression models to assess the relationship between household food access insecurity and anthropometry in children, and we assessed the invariance of that relationship across country sites. Average age of study children was 41 months. Mean food access insecurity score (range: 0-27) was 5.8, and varied from 2.4 in Nepal to 8.3 in Pakistan. Across sites, the prevalence of stunting (42%) was much higher than the prevalence of wasting (6%). In pooled regression analyses, a 10-point increase in food access insecurity score was associated with a 0.20 SD decrease in height-for-age Z score (95% CI 0.05 to 0.34 SD; p = 0.008). A likelihood ratio test for heterogeneity revealed that this relationship was consistent across countries (p = 0.17). Our study provides evidence of the validity of using a simple household food access insecurity score to investigate the etiology of childhood growth faltering across diverse geographic settings. Such a measure could be used to direct interventions by identifying children at risk of illness and death related to malnutrition.

  15. "Fotografický pohled malíře Jana Vochoče

    Czech Academy of Sciences Publication Activity Database

    Suchomelová, Marcela

    2005-01-01

    Roč. 5, č. 1 (2005), s. 49-53. ISBN 80-86712-30-3. ISSN 1213-399X Institutional research plan: CEZ:AV0Z90580513 Keywords : Portrait Photography of the Region * Privat Family Correspondence * Painter Jan Vochoč (1865-1920) Subject RIV: AC - Archeology, Anthropology, Ethnology

  16. The Earth in energy troubles; La Planete en mal d'energie

    Energy Technology Data Exchange (ETDEWEB)

    Pierret, Ch; Carroue, L; Goodchild, M F; Charvet, J P; Simon, A; Ane, J M; Auburtin, E; Barre, B; Bonin, S; Fumey, G; Daviet, S; Goupil, Ph; Helfer, M; Raison, J; Velut, S; Vidal, D; Radvanyi, J; Tapia, St de; Pourtier, R; Sebille-Lopez, Ph; Clairet, S; Poirson, A C; Guillaume, J; Collignon, B; Bauquis, P R; Brunel, S; Guillaume, J; Hourcade, B; Marchand-Vaguet, Y; Pitte, J R; Marchand-Vaguet, Y; Laherrere, J; Letourneau, M; Lemarchand, N; Beltran, A; Bret, B; Feckoua, L; Helfer, M; Lacoste, R; Manzagol, C; Tessier, F; Vanneph, A; Claessens, M; Berdevet, M; Tabeaud, M; Laherrere, J; Arnould, P; Berque, A; Brucher, W; Deshaies, M; Douguedroit, A; Husson, J P; Lemartinel, J; Mancebo, F; Baron-Yelles, N; Pitte, J R; Sede Marceau, J.H. de; Vigneau, J P; Tabeaud, M; Fremont, A; Crozet, Y; Maupu, J L; Orfeuil, J P; Savy, M; Viel, D; Hammer, A; Sanjuan, Th; Lagarec, D; Raillon, F; Koninck, R de; Bailly, A; Bruneau, M; Boulanger, Ph; Bret, B; Fournet-Guerin, C; Hourcade, J Ch; Pitte, J R; Sanjuan, Th; Verdeil, E; Butler, S de; Saint Germain, F; Bouette, N; Detot, A; Caracchioli, Ph; Bouette, N; Smaghue, N; Pousin, J; Buysse, Ph; Riallant, Y; Durand, H; Genter, A; Dieulin, C; Pronier, O; Badea, A; Tetart, F; Genevois, S; Leobet, M; Angsthelm, B; Calugaru, C; Domergue, Ph; Iacu, C; Muntele, L; Goodchild, M F; Costa, P

    2007-07-01

    This document gathers the available presentations (articles and transparencies) given at this annual meeting, the 2007 topic of which was the technological, geopolitical, economical, environmental, societal and development stakes of energy. 1 - technological stakes - which energies for the future: new energies, illusion or solution of the future; the Lorraine region, an energy land: strategies and stakes for a sustainable development; from China to Brazil: understanding the nuclear energy revival; hydroelectric power: renewable and sustainable energy; renewable energies and environment protection: the contribution of biofuels; wind power in Germany between success and contestation; 2 - geopolitical stakes - energy levier of power: the Gulf of Guinea hydrocarbons: between development and geopolitics; the complex evaluation of resources and reserves between technology, market and geopolitics; the new Bakou-Tbilissi-Ceyhan pipeline: what impacts for Turkey and the European Union; 3 - economical stakes - are public energy policies possible: the pro-alcohol program in Brazil; the surprising development of coal in the 21. century; natural gas: geo-economical and geopolitical stakes; exploitation of offshore platforms in Newfoundland: the new future of codfish island; tar sands of Alberta: promises and stakes of a 'Northern Arabia'; 4 - environmental stakes - energies responsible for the global warming: energy transformation and work in human societies; lessons learnt from the pre-industrial era: the limits of modern renewable energy sources; the energy policies in Europe: environmental constraints and geopolitical risks; reducing our energy consumption: a stake of the future; global warming and energy troubles; a territorial approach of energy, an answer to the 21. century challenges; the climate in an energy consuming world, debate and precautions; the Kyoto protocol through the geographical critics; 5 - society stakes - what energies for tomorrow's city: global design of transportation systems in Freiburg im Brisgau city (Germany); 6 - development stakes - access to energy; fatality or inequality: the energy appetite of China, between development and geopolitics; energy and health; wood fuel: the real energy crisis of the poorest southern countries; Madagascar: the lack of energy as a break to development; the challenges of the Three Gorges dam in China; geopolitics and electric power in Middle East and Lebanon; 7 - pedagogical courses: geography teaching using the map library of the French documentation; harvesting and criticizing the energy information coming from Internet; the Earth's energy troubles; petroleum in Africa, revealer of a development problem; petroleum, geopolitical stake of the present day world; the Penly nuclear power plant (Normandy, France); hydroelectric power in the Durance basin: some complex spatial stakes; wind power and land planning; the Earth's petroleum troubles; how petroleum fluxes can reveal the organization of worldwide trades; Picardie: a region in front of renewable energies; 8 - geomatics: wind farms and landscape; geothermal energy: potentialities, challenges and perspectives; Spot Image's projects of monitoring of hydrocarbon pollutions; geo-referenced databases for the agricultural and environmental management of Romania; virtual globes or educative geographical information systems: what is new for geography teaching; geo-portals: a scientific and technical tool; conflicts and petroleum, the Darfour example; the coal from Oltenie mining area (Romania): solution or puzzling problem; energy and society, which transportation policy; geo-history of petroleum in Romania; Citizens as sensors: the world of volunteered geography; the natural environment of the Danube delta. (J.S.)

  17. Household food access and child malnutrition: results from the eight-country MAL-ED study

    Directory of Open Access Journals (Sweden)

    Psaki Stephanie

    2012-12-01

    Full Text Available Abstract Background Stunting results from decreased food intake, poor diet quality, and a high burden of early childhood infections, and contributes to significant morbidity and mortality worldwide. Although food insecurity is an important determinant of child nutrition, including stunting, development of universal measures has been challenging due to cumbersome nutritional questionnaires and concerns about lack of comparability across populations. We investigate the relationship between household food access, one component of food security, and indicators of nutritional status in early childhood across eight country sites. Methods We administered a socioeconomic survey to 800 households in research sites in eight countries, including a recently validated nine-item food access insecurity questionnaire, and obtained anthropometric measurements from children aged 24 to 60 months. We used multivariable regression models to assess the relationship between household food access insecurity and anthropometry in children, and we assessed the invariance of that relationship across country sites. Results Average age of study children was 41 months. Mean food access insecurity score (range: 0–27 was 5.8, and varied from 2.4 in Nepal to 8.3 in Pakistan. Across sites, the prevalence of stunting (42% was much higher than the prevalence of wasting (6%. In pooled regression analyses, a 10-point increase in food access insecurity score was associated with a 0.20 SD decrease in height-for-age Z score (95% CI 0.05 to 0.34 SD; p = 0.008. A likelihood ratio test for heterogeneity revealed that this relationship was consistent across countries (p = 0.17. Conclusions Our study provides evidence of the validity of using a simple household food access insecurity score to investigate the etiology of childhood growth faltering across diverse geographic settings. Such a measure could be used to direct interventions by identifying children at risk of illness and death related to malnutrition.

  18. El "añadido" castellano del TJ 1 o las mal llamadas "prosiflcaciones"

    Directory of Open Access Journals (Sweden)

    Montoya Martínez, Jesús

    2002-06-01

    Full Text Available The author suggests to give the name of "addition" to the first twenty-five Cantigas de Santa María, written in prose, of the Ms TJ l. The author thinks that these additions do not come neither from Alfonso X nor from his surrouindings. They should have been added when the cultural reader was different and did not know the language of Galice. What proves this is the fact that the person who wrote this "addition" obtained information from another sources in some miracles (numbers 2 and 3 and those of praise are a theological gloss.

    El autor propone que se llame "añadido" a las hasta ahora denominadas prosificaciones castellans de las primeras veinticinco cantigas de Santa María del Ms TJ l. Él entiende que no se deben a Alfonso X, ni a su entorno. Que debieren ser añadidas en un tiempo en que el lector cultural era distinto y desconocía el gallego. Esto lo demuestra en cuanto el responsable del tal "añadido" acude a fuentes distintas en algunos milagros (números 2 y 3 y las de loor son una glosa teológica.

  19. PERAN BAITUL MAL WA TAMWIL (BMT TAQWA MUHAMMADIYAH DALAM MEMBEBASKAN MASYARAKAT DARI RENTENIR DI KOTA PADANG

    Directory of Open Access Journals (Sweden)

    Rozalinda Rozalinda

    2013-12-01

    Full Text Available This research was intended to know any factors that influence people using usurer and how did the BMT Taqwa Muhammadiyah helped people free from usurer in Padang. This research applying descriptive qualitative technique. The finding of this research showed that people were still using usurer in overcoming their financial problems due to (1 emergency need on business assistances, (2 quick process, simple procedure and shortherm paybak periode, (3 lack of bank and non bank access (4 they do not have any information of existing BMT, (5 depleted concern on religious believe on leaving excessive interest. Moreover the finding also found that BMT Taqwa Muhammadiyah had not yet provided significant financial assistance toward vendors.

  20. The Earth in energy troubles; La Planete en mal d'energie

    Energy Technology Data Exchange (ETDEWEB)

    Pierret, Ch.; Carroue, L.; Goodchild, M.F.; Charvet, J.P.; Simon, A.; Ane, J.M.; Auburtin, E.; Barre, B.; Bonin, S.; Fumey, G.; Daviet, S.; Goupil, Ph.; Helfer, M.; Raison, J.; Velut, S.; Vidal, D.; Radvanyi, J.; Tapia, St. de; Pourtier, R.; Sebille-Lopez, Ph.; Clairet, S.; Poirson, A.C.; Guillaume, J.; Collignon, B.; Bauquis, P.R.; Brunel, S.; Guillaume, J.; Hourcade, B.; Marchand-Vaguet, Y.; Pitte, J.R.; Marchand-Vaguet, Y.; Laherrere, J.; Letourneau, M.; Lemarchand, N.; Beltran, A.; Bret, B.; Feckoua, L.; Helfer, M.; Lacoste, R.; Manzagol, C.; Tessier, F.; Vanneph, A.; Claessens, M.; Berdevet, M.; Tabeaud, M.; Laherrere, J.; Arnould, P.; Berque, A.; Brucher, W.; Deshaies, M.; Douguedroit, A.; Husson, J.P.; Lemartinel, J.; Mancebo, F.; Baron-Yelles, N.; Pitte, J.R.; Sede Marceau, J.H. de; Vigneau, J.P.; Tabeaud, M.; Fremont, A.; Crozet, Y.; Maupu, J.L.; Orfeuil, J.P.; Savy, M.; Viel, D.; Hammer, A.; Sanjuan, Th.; Lagarec, D.; Raillon, F.; Koninck, R. de; Bailly, A.; Bruneau, M.; Boulanger, Ph.; Bret, B.; Fournet-Guerin, C.; Hourcade, J.Ch.; Pitte, J.R.; Sanjuan, Th.; Verdeil, E.; Butler, S. de; Saint Germain, F.; Bouette, N.; Detot, A.; Caracchioli, Ph.; Bouette, N.; Smaghue, N.; Pousin, J.; Buysse, Ph.; Riallant, Y.; Durand, H.; Genter, A.; Dieulin, C.; Pronier, O.; Badea, A.; Tetart, F.; Genevois, S.; Leobet, M.; Angsthelm, B.; Calugaru, C.; Domergue, Ph.; Iacu, C.; Muntele, L.; Goodchild, M.F.; Costa, P

    2007-07-01

    This document gathers the available presentations (articles and transparencies) given at this annual meeting, the 2007 topic of which was the technological, geopolitical, economical, environmental, societal and development stakes of energy. 1 - technological stakes - which energies for the future: new energies, illusion or solution of the future; the Lorraine region, an energy land: strategies and stakes for a sustainable development; from China to Brazil: understanding the nuclear energy revival; hydroelectric power: renewable and sustainable energy; renewable energies and environment protection: the contribution of biofuels; wind power in Germany between success and contestation; 2 - geopolitical stakes - energy levier of power: the Gulf of Guinea hydrocarbons: between development and geopolitics; the complex evaluation of resources and reserves between technology, market and geopolitics; the new Bakou-Tbilissi-Ceyhan pipeline: what impacts for Turkey and the European Union; 3 - economical stakes - are public energy policies possible: the pro-alcohol program in Brazil; the surprising development of coal in the 21. century; natural gas: geo-economical and geopolitical stakes; exploitation of offshore platforms in Newfoundland: the new future of codfish island; tar sands of Alberta: promises and stakes of a 'Northern Arabia'; 4 - environmental stakes - energies responsible for the global warming: energy transformation and work in human societies; lessons learnt from the pre-industrial era: the limits of modern renewable energy sources; the energy policies in Europe: environmental constraints and geopolitical risks; reducing our energy consumption: a stake of the future; global warming and energy troubles; a territorial approach of energy, an answer to the 21. century challenges; the climate in an energy consuming world, debate and precautions; the Kyoto protocol through the geographical critics; 5 - society stakes - what energies for tomorrow's city: global design of transportation systems in Freiburg im Brisgau city (Germany); 6 - development stakes - access to energy; fatality or inequality: the energy appetite of China, between development and geopolitics; energy and health; wood fuel: the real energy crisis of the poorest southern countries; Madagascar: the lack of energy as a break to development; the challenges of the Three Gorges dam in China; geopolitics and electric power in Middle East and Lebanon; 7 - pedagogical courses: geography teaching using the map library of the French documentation; harvesting and criticizing the energy information coming from Internet; the Earth's energy troubles; petroleum in Africa, revealer of a development problem; petroleum, geopolitical stake of the present day world; the Penly nuclear power plant (Normandy, France); hydroelectric power in the Durance basin: some complex spatial stakes; wind power and land planning; the Earth's petroleum troubles; how petroleum fluxes can reveal the organization of worldwide trades; Picardie: a region in front of renewable energies; 8 - geomatics: wind farms and landscape; geothermal energy: potentialities, challenges and perspectives; Spot Image's projects of monitoring of hydrocarbon pollutions; geo-referenced databases for the agricultural and environmental management of Romania; virtual globes or educative geographical information systems: what is new for geography teaching; geo-portals: a scientific and technical tool; conflicts and petroleum, the Darfour example; the coal from Oltenie mining area (Romania): solution or puzzling problem; energy and society, which transportation policy; geo-history of petroleum in Romania; Citizens as sensors: the world of volunteered geography; the natural environment of the Danube delta. (J.S.)

  1. Olomoucký barokní malíř Dominik Mayer (1653-1715)

    Czech Academy of Sciences Publication Activity Database

    Dolejší, Kateřina; Mlčák, L.

    -, č. 298 (2009), s. 3-16 ISSN 1212-1134 R&D Projects: GA ČR GA408/03/0059 Institutional research plan: CEZ:AV0Z80330511 Keywords : Olomouc Baroque painting * Dominik Mayer (1653-1715) * St. Michael´s church * Mater Gravida Subject RIV: AL - Art, Architecture, Cultural Heritage

  2. Utshjonõi malõi, no pedant... / Sergei Maltsev, Mihhail Petrov

    Index Scriptorium Estoniae

    Maltsev, Sergei

    2001-01-01

    Vastukaja Sergei Issakovi retsensioonile "Jamõ i uhabõ "Revelskogo trakta" ajalehes "Vesti : Nedelja Pljus" Feb/16 lk. 24 Vladimir Illjashevitshi raamatust "Revelskii trakt : istorii o russkoi Pribaltike" : Tallinn, 2001

  3. Web-marketing mix 4S v malé organizaci

    OpenAIRE

    Uhlíř, Petr

    2011-01-01

    The goal of this thesis is to evaluate whether application of the model of marketing promotion in the Internet based on the concept of web-marketing mix 4S in a small organization, sales-oriented professional machines and equipment for carpentry, plumbing and metal fabrication shop can achieve synergy and formulated key performance indicators. To achieve this goal is necessary to identify and describe technologies, tools, procedures and processes based on literature and publications that are ...

  4. Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de Meleda

    DEFF Research Database (Denmark)

    Chimienti, Fabrice; Hogg, Ronald C; Plantard, Laure

    2003-01-01

    alpha 7 nicotinic acetylcholine receptors that are present in keratinocytes. These results identify SLURP-1 as a secreted epidermal neuromodulator which is likely to be essential for both epidermal homeostasis and inhibition of TNF-alpha release by macrophages during wound healing. This explains both...

  5. Strategi Marketing Mix Baitul Mal wa Tamwil (BMT Unit Gabungan Terpadu (UGT Sidogiri Pasuruan

    Directory of Open Access Journals (Sweden)

    Cihwanul Kirom

    2016-11-01

    Full Text Available Within the business realm, marketing is a key factor which determines the success of distribution. Therefore, strategy and innovation are a necessity. Marketing activity would ensure whether a certain product is delivered to the costumers. In order to achieve the desired goals of marketing, it is important to manufacturers to follow a set of marketing processes, which comprise market overview, marketing strategy, marketing mix, and evaluation. Marketing mix is a set of strategies consist of product, price, promotion, and distribution, which guarantee the success of marketing activities. All of these aspects are intended to attain responses from the targeted market. The article seeks to discuss the marketing mix strategy implemented by BMT UGT Sidogiri Pasuruan based on four “Ps”, namely product, price, place, and promotion. The study finds that the marketing mix strategy employed by BMT UGT has met the costumers’ needs in terms of product strategy, pricing strategy, distribution strategy, and promotion strategy. The study also concludes that the proper implementation of marketing mix strategy and its compatibility with Islamic sharîʻah as well as the organization’s obedience towards Islamic business ethics are among pivotal factors that have significantly influenced the development of BMT UGT Sidogiri

  6. Saga do computador mal-amado Saga del ordenador malamado Saga of the unloved computer

    Directory of Open Access Journals (Sweden)

    Claudio de Moura Castro

    2010-09-01

    Full Text Available O que a tecnologia tem a oferecer para a educação é cada vez mais abundante, criativo e confiável. Seja nas tecnologias de imagem, nos computadores e nas suas combinações, a oferta é quase ilimitada. Não obstante, as escolas acadêmicas não conseguem usar com sucesso tais recursos. Há ampla evidência de que iniciativas bem focalizadas mostram resultados muito positivos. Contudo, tais sucessos não se generalizam e a maioria dos estudos mostra resultados pífios para os sistemas educativos como um todo. A sociologia da escola acadêmica e a tecnologia se enfrentam em batalhas em que saem perdendo os alunos. Não obstante, os computadores nas casas dos alunos tendem a melhorar o seu rendimento. Ainda mais admirável, a miríade de soluções educativas não-formais fazem excelente uso de todas as tecnologias.Lo que la tecnología tiene para ofrecerle a la educación es cada vez más amplio, creativo y confiable. La oferta es casi ilimitada, ya sea en tecnología de imagen, en variedad de ordenadores (computadoras o en sus diversas combinatorias. Sin embargo, los centros académicos no logran utilizarlos en forma exitosa. Hay amplia evidencia de que cuando las iniciativas están bien focalizadas resultan beneficiosas para los estudiantes. El problema es que tales resultados no se generalizan en los sistemas educativos. La consecuencia es que no mejora el rendimiento de los estudiantes. Es como si la sociología de la escuela estuviera en guerra con la tecnología. Por supuesto, los que pierden son los estudiantes. Pero, cuando los ordenadores están en los hogares de los estudiantes, su aprendizaje puede mejorar. Y más loable aún es que la educación no formal impulsa la tecnología educativa con gran éxito.What technology has to offer to education is ever more abundant, creative and reliable. Be it in the image technology, in the computers and in their combinations, the possibilities are almost endless. Nevertheless, academic schools fail to materialize the benefits one could expect from such resources. While there is ample evidence that well-focused initiatives show positive results on learning, this learning potential does not generalize for educational systems as a whole. School sociology is at odds with the modes of utilization that would make a difference. As a result, students lose. In contrast, computers in students' homes improve learning. Even more admirable, non-formal schooling modes have been using technology with ample success.

  7. Los vegetales en la terapéutica del "mal de Hansen"

    Directory of Open Access Journals (Sweden)

    Hernando García Barriga

    1943-10-01

    nuestro territorio que hacen parte del Herbario Nacional Colombiano, con algunos datos consignados en libros científicos extranjeros que han llegado a nuestro conocimiento, advirtiendo que lo hacemos con el ánimo de contribuír a la ciencia, así sea en tan modestas proporciones.

  8. Diagnostic dilemma in vascular mal-formation of the upper lip: a ...

    African Journals Online (AJOL)

    richard

    2014-09-08

    Sep 8, 2014 ... Radiography, Lagos University Teaching Hospital, Lagos. *Corresponding author: ... To present a case of vascular lesion on the upper lip and its management. Methods: We .... midline of the face without bone involvement.

  9. Aktivitas Public Relations Mal Ciputra Seraya Pekanbaru Dalam Upaya Meningkatkan Citra Perusahaan

    OpenAIRE

    ", NURJANAH; Monani, Sylvia

    2014-01-01

    When the Ciputra Seraya Pekanbaru Mall got crisisses that are related to the accidents successively in 2012 and the issuesregarding of employees who resigned because of inconvenience to the company, the image of Ciputra Mall remains good even thus increased. Therefore, this research was conducted with the purposes are :to understand the roles and functions of public relations of Ciputra Seraya Pekanbaru Mall as one of the efforts to increase its image, to find out the activities of public rel...

  10. Context effects and the (mal)adaptive nature of guilt and shame in children.

    Science.gov (United States)

    Ferguson, T J; Stegge, H; Eyre, H L; Vollmer, R; Ashbaker, M

    2000-08-01

    Symptoms of internalization were examined in relation to children's self-reports of three emotions in situations that were either ambiguous or unambiguous as to the child's responsibility for various standard violations. Children ranging in age from 6 to 13 years were drawn from elementary schools (61 boys, 79 girls, mean age = 8.7) and from a community mental health center (23 boys, 18 girls, mean age = 8.5) to which they had been referred for problems related to internalization or externalization. Shame proneness was consistently linked to internalizing symptoms across contexts. Guilt proneness, in response to ambiguous scenarios, was also associated with internalization, whereas pride responses were unrelated to symptoms. Few age- or gender-related differences were found. The results cast doubt on notions that self-conscious emotions, such as guilt, are necessarily adaptive or maladaptive. Systematic research is needed to understand which features of any emotion contribute to children's psychological adjustment.

  11. Malestar y autobiografía = Mal-estar e autobiografia

    Directory of Open Access Journals (Sweden)

    Caballé, Anna

    2013-01-01

    Full Text Available O artigo aborda o modo como os avanços no campo da neurociência estão repercutindo nos estudos sobre a autobiografia, que se beneficiam de aportes sobre o funcionamento da memória (muito simplificada em relação ao sustentado pela psicologia cognitiva e da identidade (ou Self. A ideia é de que a identidade reside primeiro no corpo e só depois na mente. O artigo privilegia algumas contribuições literárias recentes (Vicente Verdú, Marcos Ordóñez, Javier Pérez Andújar cuja escrita, abertamente autobiográfica, se vincula à experiência do corpo e às suas alterações. Isso sugere uma concepção fraturada da autobiografia como sendo a mais sintonizada com os tempos atuais, quando a narração compacta do ser parece impossível

  12. MAL Daylight Photodynamic Therapy for Actinic Keratosis: Clinical and Imaging Evaluation by 3D Camera.

    Science.gov (United States)

    Cantisani, Carmen; Paolino, Giovanni; Pellacani, Giovanni; Didona, Dario; Scarno, Marco; Faina, Valentina; Gobello, Tommaso; Calvieri, Stefano

    2016-07-11

    Non-melanoma skin cancer is the most common skin cancer with an incidence that varies widely worldwide. Among them, actinic keratosis (AK), considered by some authors as in situ squamous cell carcinoma (SCC), are the most common and reflect an abnormal multistep skin cell development due to the chronic ultraviolet (UV) light exposure. No ideal treatment exists, but the potential risk of their development in a more invasive form requires prompt treatment. As patients usually present with multiple AK on fields of actinic damage, there is a need for effective, safe, simple and short treatments which allow the treatment of large areas. To achieve this, daylight photodynamic therapy (DL-PDT) is an innovative treatment for multiple mild actinic keratosis, well tolerated by patients. Patients allocated to the PDT unit, affected by multiple mild-moderate and severe actinic keratosis on sun-exposed areas treated with DL-PDT, were clinically evaluated at baseline and every three months with an Antera 3D, Miravex(©) camera. Clinical and 3D images were performed at each clinical check almost every three months. In this retrospective study, 331 patients (56.7% male, 43.3% female) were treated with DL-PDT. We observed a full clearance in more than two-thirds of patients with one or two treatments. Different responses depend on the number of lesions and on their severity; for patients with 1-3 lesions and with grade I or II AK, a full clearance was reached in 85% of cases with a maximum of two treatments. DL-PDT in general improved skin tone and erased sun damage. Evaluating each Antera 3D images, hemoglobin concentration and pigmentation, a skin color and tone improvement in 310 patients was observed. DL-PDT appears as a promising, effective, simple, tolerable and practical treatment for actinic damage associated with AK, and even treatment of large areas can be with little or no pain. The 3D imaging allowed for quantifying in real time the aesthetic benefits of DL-PDT's increasing compliance.

  13. František Kupka - malíř mezi kanóny

    Czech Academy of Sciences Publication Activity Database

    Pravdová, A.; Winter, Tomáš

    2012-01-01

    Roč. 34, č. 10 (2012), s. 32-35 ISSN 0418-5129 Institutional research plan: CEZ:AV0Z80330511 Keywords : Czech fine art of 20th century * caricature * propaganda Subject RIV: AL - Art, Architecture, Cultural Heritage

  14. Esperanzas zozobradas. Apuntes de la primera mitad del siglo xx: El siglo empieza mal

    Directory of Open Access Journals (Sweden)

    Gert Hoffmann

    2009-12-01

    Full Text Available En el presente artículo se relata la historia de vida de un excombatiente austriaco de la Guerra Civil española por el bando republicano hasta su retirada del frente tras la batalla del Ebro. Se expondrán las circunstancias de su nacimiento, concienciación política y participación en el conflicto que asoló España durante tres años. En primer lugar, se destacará la importancia de la I Guerra Mundial para la comprensión de la vida en Austria hasta el Anschluss y en concreto el frente italiano como punto de inflexión tanto para la balanza de la victoria como de la definitiva derrota del imperio austro-húngaro. En segundo lugar, se relatarán las tensiones y hechos de violencia social vividos en Austria en los días previos al Anschluss, la militancia política del autor y su decisión de ingresar en las Brigadas Internacionales para venir a combatir a España. Finalmente, se describirá el proceso de reclutamiento y viaje a la Península Ibérica para terminar la narración de su participación en la contienda con la batalla del Ebro y su posterior salida tras la orden gubernamental del 23 de septiembre de 1938.___________________ABSTRACT:This article deals with the history of life of an Austrian ex-combatant of the Spanish Civil War by the republican side, until his retire after the Battle of the Ebro. Circumstances of his birth, political awareness and participation in the Spanish Civil War, that will knock down Spain during three years, are here shown. Firstly, it will be explained the importance of the I World War for the understanding of the life in Austria until the Anschluss, and the meaning of the Italian front as a turning point for the victory or the defeat of the Austro-Hungarian Empire. Secondly, tensions and episodes of social violence occurred in Austria in the first days of the Anschluss, will be described: the author's political militancy and his decision of joining the International Brigades for fighting in Spain, are also pointed up. Finally, the recruitment process and his voyage to Spain are described and his narration ends with his participation in the Battle of the Ebro and his consequent quit after the September 23, 1938 governmental order.

  15. Sagittal plane mal-alignment in lumbar spinal radiographs in a ...

    African Journals Online (AJOL)

    Background: Plane radiograph of the spine is still the primary or first line investigation in patients with a variety of symptoms including back pain in a resource limited setting like ours. Methods: A crosssectional study of radiographs of patients who were referred to Radiology Department of Jos University Teaching Hospital for ...

  16. SLURP1 is a late marker of epidermal differentiation and is absent in Mal de Meleda

    DEFF Research Database (Denmark)

    Favre, Bertrand; Plantard, Laure; Aeschbach, Lorène

    2007-01-01

    and MDM skin. SLURP1 was found to be a marker of late differentiation, predominantly expressed in the granular layer of skin, notably the acrosyringium. Moreover, SLURP1 was also identified in several biological fluids such as sweat, saliva, tears, and urine from normal volunteers. In palmoplantar...... sections from MDM patients, as well as in their sweat, mutant SLURP1, including the new variant R71H-SLURP1, was either absent or barely detectable. Transfected human embryonic kidney 293T cells expressed the MDM mutant SLURP1 containing the single amino-acid substitution G86R but did not tolerate the MDM...

  17. Mosquitos transgênicos para o controle da malária: progressos e desafios

    OpenAIRE

    Moreira, Luciano A.; Jacobs-Lorena, Marcelo

    2003-01-01

    Malaria kills millions of people every year and the current strategies to control the disease, such as insecticides and drugs have not been completely efficient. Because of that, novel means to fight against malaria are of utmost importance. Advances in the study of the mosquito vector and its interactions with the malaria parasite made scientists think that it is possible to genetically manipulate the mosquitoes to make them inefficient vectors. Here we review the advances on the introductio...

  18. Rozvoj malého a stredného podnikania v Slovenskej republike

    Directory of Open Access Journals (Sweden)

    Irina Bondareva

    2013-11-01

    Full Text Available Purpose of the article: Slovakia's accession to the EU caused an increased role for small and medium entrepreneurship in the economy and simultaneously increased the requirements for this sector of the economy in view of the high competition in the European market. At the same time small and medium-sized enterprises SR face major difficulties which adversely affect their development. In this context, it is necessary to continuously monitor the business environment for the purpose of removing obstacles to business. Methodology/methods: The method of research is time series analysis of small and medium-sized enterprises SR, analysis of the structure of economic activity, synthesis of information provided by various institutions dealing with the rating business. Scientific aim: The article is to examine trends in the development of small and medium enterprises in Slovakia during the year 2004 - 2009 and evaluate the current business environment of the SR. Findings: The analysis shows that the number of small and medium-sized enterprises in the years 2004-2009 in Slovakia has an increasing trend. During this period, major barriers have been removed in the normative and legal acts, particularly the creation of new firms, has made tax reform introduced a flat tax on income, to adopt transparent rules on state aid to investors. Positive impact on the development of small and medium-sized enterprises have so stable macroeconomic and political situation in Slovakia. Conclusions (limits, implications etc However, there remains a considerable number of factors that complicate their development. In particular, it is a poor law enforcement, inadequate capacity, quality and availability of credit information for efficient and safe lending, which has restricted access to bank loans, lack of qualified entrepreneurs, large scale and long term to meet the established administrative procedures, high tax and contribution burden , fee burden on businesses, the low level of protection of investors. To improve the business environment is necessary to remove these barriers.

  19. Bilateral recurrent anterior fracture dislocation of shoulder joint due to grand mal epileptic convulsions

    Directory of Open Access Journals (Sweden)

    Chandrashekara Chowdipalya Maliyappa

    2013-01-01

    Full Text Available Bilateral shoulder dislocation is very much common with convulsions of different etiology. Often, these dislocations are associated with fractures due to violent muscle contractions. The typical lesion is bilateral posterior dislocation or fracture dislocations. The recurrent shoulder dislocations are common with traumatic etiology. The lack of asymmetry of the shoulders is stressed as a potential pitfall in the clinical evaluation of patients with this condition. We present a rare case of bilateral recurrent anterior fracture dislocation of the shoulder sustained due to repetitive episodes of convulsive seizures. Patient was treated by close reductions and immobilization on each episode. In epilepsy although posterior dislocations are common, the rare possibility of bilateral anterior fracture dislocation should be kept in mind. Often these patients are vulnerable for recurrence, similar to traumatic cases.

  20. Cognitions as determinants of (mal)adaptive emotions and emotionally intelligent behavior in an organizational context.

    Science.gov (United States)

    Spörrle, Matthias; Welpe, Isabell M; Försterling, Friedrich

    2006-01-01

    This study applies the theoretical concepts of Rational Emotive Behavior Therapy (REBT; Ellis, 1962, 1994) to the analysis of functional and dysfunctional behaviour and emotions in the workplace and tests central assumptions of REBT in an organizational setting. We argue that Ellis' appraisal theory of emotion sheds light on some of the cognitive and emotional antecedents of emotional intelligence and emotionally intelligent behaviour. In an extension of REBT, we posit that adaptive emotions resulting from rational cognitions reflect more emotional intelligence than maladaptive emotions which result from irrational cognitions, because the former lead to functional behaviour. We hypothesize that semantically similar emotions (e.g. annoyance and rage) lead to different behavioural reactions and have a different functionality in an organizational context. The results of scenario experiments using organizational vignettes confirm the central assumptions of Ellis' appraisal theory and support our hypotheses of a correspondence between adaptive emotions and emotionally intelligent behaviour. Additionally, we find evidence that irrational job-related attitudes result in reduced work (but not life) satisfaction.

  1. L’image de l’Orient dans les Fleurs du Mal

    Directory of Open Access Journals (Sweden)

    AL-Nasser Nada

    2016-11-01

    Full Text Available In this research, we try to shed light on the important place that the East occupies in the literary library in the world and particularly in France. Indeed, the East attracts much attention of men of letters since the Crusades (Chateaubriands, Lamartine, Hugo, Rousseau... etc. and love for him grew with time especially in the 19th century (the era of progress and science. However, Baudelaire did not see the Orient as a geographical place but an idea and a literary aesthetic that adds beauty to his poetry. Through this research, we try to reveal the mechanism by which Baudelaire introduced the East in his Flowers speaking of his ability to link the concrete (the East to the abstract (the beauty and perfection.

  2. Crowns to create esthetics for mal-aligned central incisors: a case report.

    Science.gov (United States)

    Savadi, Ravindra C; Savadi, Anupama R; Kumar, Preeti Satheesh

    2011-06-01

    This case report describes the smile design of crowded upper central anteriors in a female patient aged 25 years. The patient wanted the correction to be completed in a short period of time. A smile design schedule was drawn up involving root canal treatment of the central incisors and placing posts in both the teeth. All ceramic crowns were then fabricated to establish a very satisfactory and pleasing esthetics.

  3. Crowns to Create Esthetics for Mal-Aligned Central Incisors: A Case Report

    OpenAIRE

    Savadi, Ravindra C.; Savadi, Anupama R.; Kumar, Preeti Satheesh

    2011-01-01

    This case report describes the smile design of crowded upper central anteriors in a female patient aged 25 years. The patient wanted the correction to be completed in a short period of time. A smile design schedule was drawn up involving root canal treatment of the central incisors and placing posts in both the teeth. All ceramic crowns were then fabricated to establish a very satisfactory and pleasing esthetics.

  4. Tartışmalı Endikasyonlarında ESWL

    OpenAIRE

    Gürpınar, Dr. Tayfun; Özkan, Dr. Semih

    1995-01-01

    ESWL (Extracorporeal Shock Wave Lithotripsy) üriner sistem taş hastalığının tedavisini tümüyle değiştirmiştir Elde edilen deneyim bu teknolojinin güvenli ve etkili olduğunu ancak taş hastalığı tedavisinde sınırları olduğunu göstermektedir. Anahtar kelimeler: ESWL, üriner sistem taşları