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Sample records for benigna mal diagnosticada

  1. Vertigem de posicionamento paroxística benigna

    OpenAIRE

    Pereira Cristiana Borges; Scaff Milberto

    2001-01-01

    A vertigem de posicionamento paroxística benigna é um distúrbio vestibular de diagnóstico fácil, baseado no exame neurológico e tratado com manobras de liberação. Nesta revisão, a fisiopatologia, os aspectos clínicos e as diferentes manobras são sucintamente discutidos.

  2. Lipomatosis simétrica benigna de la lengua en la enfermedad de Madelung Benign symmetric lipomatosis of the tongue in Madelung’s disease

    Directory of Open Access Journals (Sweden)

    A. López Ceres

    2006-04-01

    Full Text Available La enfermedad de Madelung, o lipomatosis simétrica benigna es una enfermedad rara caracterizada por acúmulos grasos no encapsulados localizados de forma simétrica alrededor de cuello y hombros. Esta enfermedad, afecta predominantemente a hombres en edades comprendidas entre los 30 y 60 años, con una relación hombre:mujer de 15:1. Existe una gran relación con el abuso del alcohol. Las personas no alcohólicas y las mujeres también pueden verse afectadas, aunque de forma más rara. Presentamos el caso de una mujer diagnosticada de Enfermedad de Madelung refiriendo engrosamiento progresivo de la lengua. Presentaba dificultad para tragar, disartria y disnea con el decúbito.Madelung´s disease, or benign symmetric lipomatosis, is an uncommon disease characterized by non-encapsulated accumulations of fat in a symmetric manner around the neck and shoulders. This uncommon disease predominantly affects men between the ages of 30 and 60 and it has a 15:1 ratio. There is a strong correlation with alcohol abuse. Nonalcoholics and women can also be affected although this is rare. We report the case of a woman diagnosed with Madelung’s disease, who described a gradual swelling of the tongue. She had difficulty swallowing, dysarthria and dyspnea while sleeping.

  3. Lesiones benignas de la mama y riesgo de cáncer de mama

    OpenAIRE

    Torres Ardanuy, Silvia

    2006-01-01

    Hipótesis de trabajo. Una historia de biopsia con resultado de patología mamaria benigna, presentan un riesgo de cáncer de mama posterior. Page y Dupont encontraron que las lesiones proliferativas con atipias tienen un RR de 4-5 para cáncer de mama, las lesiones proliferativas sin atipias tienen un RR de 1,5-2 y lesiones benignas de tipo no proliferativo no están asociadas con riesgo de cáncer de mama subsecuente. Sin embargo existen estudios contradictorios para cada una de las lesiones. Mat...

  4. O MAL EM ERIC WEIL

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    Daniel Benevides Soares

    2014-12-01

    Full Text Available O mal ocupa a condição de problema para a filosofia desde a Antiguidade. Passando pelas ponderações dos estóicos e de Santo Agostinho, tratado no contexto da teodiceia por Leibniz, o mal aporta como objeto de preocupação para a moral em Kant. Muito conhecido por sua definição como um kantiano pós-hegeliano, é com Kant, mas indo além dele que Weil trata do mal, pensando-o como formas de violência. Considerada como o outro do sentido e da razão, a violência se manifesta de maneiras variadas. Nosso intuito é determinar o conceito de mal em Eric Weil enquanto forma de violência. Para isso, nos propomos a situar no esquema conceitual da violência duas formas de mal discutidas por Weil nos seus textos: o mal radical e o mal diabólico.

  5. El Gobierno del mal menor

    DEFF Research Database (Denmark)

    Agustin, Oscar Garcia

    2012-01-01

    El Gobierno no aspira a ser bueno ni malo. Se conforma con ser el Gobierno del mal menor, cuyas medidas drásticas y poco populares están destinadas a salvar a los ciudadanos del desastre que no ha llegado todavía pero podría llegar.......El Gobierno no aspira a ser bueno ni malo. Se conforma con ser el Gobierno del mal menor, cuyas medidas drásticas y poco populares están destinadas a salvar a los ciudadanos del desastre que no ha llegado todavía pero podría llegar....

  6. Indicadores de calidad en hiperplasia benigna de próstata. Un estudio cualitativo

    OpenAIRE

    Jorge Navarro-Pérez; Salvador Peiró; Francisco Brotons-Muntó; Emilio López-Alcina; Arcadio Real-Romaguera

    2014-01-01

    Objetivo: Valorar posibles indicadores de calidad de la atención a la hiperplasia benigna de próstata (HBP) y sus fortalezas y debilidades para su incorporación a los sistemas de información sanitaria. Diseño: Reunión de expertos, estructurada siguiendo procedimientos adaptados de las técnicas de grupo nominal y método de consenso Rand. Emplazamiento: Escuela Valenciana de Estudios de la Salud. Participantes y/o contextos: Participaron 40 panelistas (74% médicos, 70% del ámbito de la...

  7. Repolarización precoz: de benigna a muerte súbita

    OpenAIRE

    Guillermo Trout; Luis Rodríguez; Rafael Gallego; Samuel Jarava

    2013-01-01

    Title: Early repolarization: from benign to sudden death La repolarización precoz es un hallazgo frecuente caracterizado por elevación del segmento ST, empastamiento al final del QRS en 2 o más derivadas electrocardiográficas contiguas. Durante años fue considerada benigna, pero actualmente observaciones de casos, estudios clínicos y electrofisiológicos sugieren un rol crítico en la patogénesis de la fibrilación ventricular idiopática. Estudios poblacionales establecieron asociación entre est...

  8. INTERVENCIÓN GRUPAL Y CALIDAD DE VIDA EN PERSONAS DIAGNOSTICADAS DE VIH

    OpenAIRE

    Ana Fernanda Uribe Rodríguez

    2005-01-01

    El objetivo de esta investigación es identificar las áreas de mayor y menor nivel en la calidad de vida de las personas diagnosticadas de VIH antes y después de una intervención grupal. La muestra fue de 19 hombres diagnosticados de VIH, cuya edad oscila entre 30 y 50 años. Es una investigación cuasiexperimental con diseño pre y pos prueba con grupo control y experimental. Se utilizó el Cuestionario Multidimensional de Calidad de vida para personas con VIH/sida. Durante cuatro meses se realiz...

  9. El proceso creativo en personas diagnosticadas de Trastorno de la Conducta Alimentaria

    OpenAIRE

    Gutiérrez Ajamil, Estibaliz

    2013-01-01

    La finalidad de este estudio es comprender las consecuencias psicológicas y emocionales que el proceso creativo provoca en personas diagnosticadas de Trastornos de la Conducta Alimentaria (TCA). Para ello, se desglosa el trabajo en dos partes: En la primera se analiza el estado de la cuestión a partir de una revisión de la literatura en la que se estudian en paralelo la situación emocional que viven las personas con TCA y las estructuras psíquicas necesarias para la elaboración del proceso cr...

  10. Prevalência e associações da vertigem posicional paroxística benigna em idosos

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    Michelle Damasceno Moreira

    2014-10-01

    Full Text Available OBJETIVO:verificar a prevalência da vertigem posicional paroxística benigna e identificar suas prováveis associações em uma população de idosos.MÉTODOS:estudo transversal realizado em idosos, submetidos à avaliação audiológica, questionário e à Manobra de Dix-Hallpilke. Aplicaram-se os testes não paramétricos: Qui-quadrado e regressão multivariada com intervalo de confiança de 95%.RESULTADOS:a amostra final foi de 494 indivíduos, com mediana de idade de 69(64,75- 74,00 anos. Observou-se a prevalência de 23,9% de vertigem posicional paroxística benigna e 51,6% de dor cervical e 37,9% de cefaléia. Houve associação estatisticamente significante entre a vertigem posicional paroxística benigna e dor cervical, gênero e cefaléia nesta população.CONCLUSÃO:conclui-se que nesta população de idosos a prevalência da vertigem posicional paroxística benigna foi de 23,9% e da dor cervical foi de 51,6% e houve associação significante entre a vertigem posicional paroxística benigna com a dor cervical e com o gênero feminino.

  11. Regulation of the malic enzyme gene malE by the transcriptional regulator MalR in Corynebacterium glutamicum.

    Science.gov (United States)

    Krause, Jens P; Polen, Tino; Youn, Jung-Won; Emer, Denise; Eikmanns, Bernhard J; Wendisch, Volker F

    2012-06-15

    Corynebacterium glutamicum is a Gram-positive nonpathogenic bacterium that is used for the biotechnological production of amino acids. Here, we investigated the transcriptional control of the malE gene encoding malic enzyme (MalE) in C. glutamicum ATCC 13032, which is known to involve the nitrogen regulator AmtR. Gel shift experiments using purified regulators RamA and RamB revealed binding of these regulators to the malE promoter. In DNA-affinity purification experiments a hitherto uncharacterized transcriptional regulator belonging to the MarR family was found to bind to malE promoter DNA and was designated as MalR. C. glutamicum cells overexpressing malR showed reduced MalE activities in LB medium or in minimal media with acetate, glucose, pyruvate or citrate. Deletion of malR positively affected MalE activities during growth in LB medium and minimal media with pyruvate, glucose or the TCA cycle dicarboxylates l-malate, succinate and fumarate. Transcriptional fusion analysis revealed elevated malE promoter activity in the malR deletion mutant during growth in pyruvate minimal medium suggesting that MalR acts as a repressor of malE. Purified MalR bound malE promoter DNA in gel shift experiments. Two MalR binding sites were identified in the malE promoter by mutational analysis. Thus, MalR contributes to the complex transcriptional control of malE which also involves RamA, RamB and AmtR. PMID:22261175

  12. Enfermedades pleurales benignas inducidas por asbesto Benign pleural diseases induced by asbestos

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    J. Boldú

    2005-01-01

    Full Text Available La exposición al asbesto es una causa importante de patología pleural y se puede producir con intensidades moderadas o ligeras dada la capacidad del asbesto de concentrarse en la pleura. Ello motiva junto a la prolongada latencia existente entre la exposición y la enfermedad, que sigamos viendo durante muchos años manifestaciones clínicas pleurales de exposición previa, a pesar del uso del asbesto cada vez más limitado en las últimas décadas. Dicha exposición puede presentarse con distintas manifestaciones tanto malignas como el mesotelioma como benignas, siendo las principales de éstas el derrame pleural benigno, las placas pleurales, la fibrosis pleural difusa y la atelectasia redonda.Exposure to asbestos is an important cause of pleural pathology and can be produced with light or moderate tendencies given the capacity of asbestos to concentrate in the pleura. Together with the prolonged latency existing between exposure and the disease, this means that for many years we will continue to see pleural clinical manifestations from past exposure, in spite of the increasingly limited use of asbestos in recent decades. This exposure can show itself in different manifestations, both malign, such as mesothelioma, and benign, principally benign pleural effusion, pleural plaques, diffuse pleural fibrosis and massive atelectasis.

  13. The mean age of petit mal epilepsy

    Science.gov (United States)

    Syeda, Afsarunnesa; Karim, Md. Rezaul

    2016-01-01

    Objective: Petit mal epilepsy or absence seizures involve brief, sudden lapses of consciousness and most often occurs in people under age of 20 years. This study was done to find out the most likely significant age affected by petit mal epilepsy and whether they had higher rate of behavioral, educational, and social problems. Materials and Methods: We run tests on total 32 patients (male 16 and female 16) from newborns to 20 years of age. Results: The most affected ages were from 4 to 9 years and both genders were equally affected. They have higher rate of behavioral, educational, and social problems, and most likely recovering ages from the disease were from 15 to 20 years. Conclusion: These findings could contribute in diagnosis and treatment of Petit Mal Epilepsy, as it often misinterpreted as daydreaming or inattention.

  14. Biologia da nidificação de Megachile (Moureapis benigna Mitchell

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    Frederico Teixeira

    2011-11-01

    Abstract. This paper describes the biology, ecology and nest architecture of Megachile (Moureapis benigna Mitchell in trap nests (NA. The NA were installed in five forest fragments of 2.1 to 920ha, and two disturbed areas (pasture and plantation. We used bamboo canes (NB and black cardboard tubes placed on wooden boards (NC to attract nesting females. Bees occupied 17 NA (12 NB - 9 to 21mm in diameter - and 5 NC - 8 to 10mm in four forest fragments forming 26 nests (one to six nests per NB. No nest was founded in disturbed areas. There was no difference between NB and NC related to the size of formed nests (t= 0.31, p= 0.763, df= 25. The number of cells ranged from 1 to 13 per nest, being larger in NB than in NC (t= 2.26, p= 0.033, df= 25. The construction activity occurred during the rainy season (October to March, with no correlation to climate parameters. Emergence (1 to 12 per nest was correlated with humidity (t= 3.013, p= 0.006. Time to adult emergence varied from 1 to 141 days. The sex ratio was 1.8:1 male/female, differing from 1:1 (Χ2= 9.39, p<0.002. The parasites were Coelioxys otomita Cresson and two other species of Coelioxys. The species demonstrates plasticity in nesting substrate, and preference for cavities with diameters larger than 9mm. There is a possible dependence of the species to forest environments, since the higher occurrence of nesting was in forest areas in advanced stages of regeneration.

  15. Mal'tsev algebras and triality

    International Nuclear Information System (INIS)

    A concept of the Mal'tsev pair is presented. This concept is based on the generalized Maurer-Cartan equations of a local analytic Moufang loop. The triality can be seen as a fundamental property of such pairs. Based on triality, the Yamagutian is constructed. Properties of the Yamagutian are studied.

  16. Malária falciparum resistente à cloroquina e ao Fansidar R tratada com minociclina Minocycline treatment of chloroquine-and Fansidar R-resistant falciparum malarial

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    José J. Ferraroni

    1983-08-01

    Full Text Available Em abril de 1978 uma infecção malárica causada por Plasinodium falciparum foi diagnosticada em um paciente adulto do sexo masculino, nativo da Amazônia brasileira. O parasito foi resistente in vitro à cloroquina e in vivo à associação pirimetamina + sulfadoxina (FansidarR. O paciente foi tratado com minociclina (MinomaxR; contudo, sua resposta imune ao parasito pode ter tido um importante papel na eficácia do tratamento com a minociclina.In April 1978, a Plasmodium falciparum infection was diagnosed in an adult male in Brazilian Amazonia. The parasite was resistant in vitro to chloroquine and resistent in vivo to pyrimethamine-sulfadoxine (FansidarR. The patient was successfully treated with minocycline (MinomaxR; however, his immune response to the parasite may have played an important role in the efficacy of the minocycline treatment.

  17. Tuberculosis laríngea diagnosticada en una escolar Laryngeal tuberculosis diagnosed in a school girl

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    Marcela González L

    2006-09-01

    Full Text Available La tuberculosis (TBC es en la actualidad una endemia a nivel mundial. La tuberculosis extrapulmonar, menos frecuente que la forma pulmonar constituye un desafío diagnóstico. La forma laríngea representa menos del 1% de las tuberculosis extrapulmonares. En esta publicación, presentamos un caso de tuberculosis laríngea diagnosticada en una escolar de nuestro servicio de pediatría hospital Dr. Gustavo Fricke, cuyos síntomas cardinales fueron disfonía y tos presentes durante 6 meses previo al diagnóstico. Al momento de ingreso al servicio se había agregado compromiso del estado general, odinofagia estridor y dificultad respiratoria. Al examen físico destacaba la presencia de masa cervical. El diagnóstico se realizó mediante laringoscopia directa que evidenció nódulo en cuerda vocal derecha cuya biopsia reveló presencia de proceso inflamatorio crónico granulomatoso compatible con TBC. Las baciloscopías y cultivo de Koch de expectoración, realizados al momento del ingreso, resultaron positivos. Cabe destacar el retraso diagnóstico del caso, debido a que nunca se planteó realizar laringoscopia durante el estudio ambulatorio, pese a la presencia de disfonía y tos persistenteTuberculosis is at the present time a worldwide endemic disease. Extrapulmonary tuberculosis is less frequent than the pulmonary form and its diagnosis represents a challenge. Laryngeal tuberculosis accounts for less than 1% of extrapulmonary tuberculosis. In this report, we present a case of laryngeal tuberculosis diagnosed in a 12 years old girl at the pediatric department of a general hospital. The patient had a six months history of hoarseness and persistent cough. At the time she was admitted at the hospital she complainted about stridor, odynophagia, weakness and respiratory distress. A cervical mass was the main finding at her physical exam. A laryngeal nodule was shown after practicing a direct laryngoscopy. The biopsy of this lesion revealed presence of

  18. Epilepsias generalizadas idiopáticas diagnosticadas incorretamente como epilepsias parciais

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    Mory Susana B.

    2002-01-01

    Full Text Available A epilepsia generalizada idiopática (EGI frequentemente não é diagnosticada corretamente em adultos, com sérias consequências para os pacientes. O objetivo deste estudo foi avaliar os fatores mais frequentemente associados a dificuldades no diagnóstico diferencial entre epilepsias parciais e generalizadas em adultos. Avaliamos 41 pacientes com diagnostico de crises parciais complexas com elementos de anamnese e EEG indicando um possível diagnóstico diferencial. Foi possível a mudança do diagnóstico de epilepsia parcial para EGI em 25 pacientes: 22 (88% com EMJ; um com ausência juvenil, um com síndrome de ausências com mioclonias periorais e um com ausência com mioclonias palpebrais. Mioclonias, uma das características da EMJ e outras formas de EGI, geralmente não eram espontaneamente relatadas pelos pacientes. Abalos mioclônicos unilaterais eram confundidos com crises parciais motoras. Ausências breves e pouco frequentes e anormalidades focais no EEG contribuíram para o não reconhecimento de EGI. Todos os 25 pacientes apresentavam crises sem controle adequado antes da revisão diagnóstica. Após o diagnóstico correto e mudança para monoterapia com acido valpróico ou valproato de sódio, 19 (76% ficaram livre de crises e seis (24% dos 25 pacientes apresentaram melhora significativa. A associação de lamotrigina em três destes pacientes propiciou redução significativa da frequência de crises. Em conclusão, anamnese detalhada e questionamento direcionado para determinar a presença de mioclonias e crises tipo ausência e a sua interpretação no contexto clínico são fundamentais para o diagnóstico correto das EGI em adultos.

  19. El estigma en mujeres diagnosticadas con VPH, displasia y cáncer cervicouterino en Hermosillo, Sonora

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    María del Carmen Arellano Gálvez

    2013-01-01

    Full Text Available Nuestro objetivo es indagar sobre las vivencias y percepciones de un grupo de mujeres de una ciudad al norte de México que han sido diagnosticadas con el virus del papiloma humano, displasias y cáncer cervicouterino. Realizamos treinta y cuatro entrevistas cualitativas; se identificó que las mujeres viven la experiencia de diagnóstico como un estigma, pues alude a su sexualidad, fidelidad y creencias religiosas, por lo que ponen en marcha estrategias protectoras para evitar ser estigmatizadas.

  20. Repolarización precoz: de benigna a muerte súbita

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    Guillermo Trout

    2013-11-01

    Full Text Available Title: Early repolarization: from benign to sudden death La repolarización precoz es un hallazgo frecuente caracterizado por elevación del segmento ST, empastamiento al final del QRS en 2 o más derivadas electrocardiográficas contiguas. Durante años fue considerada benigna, pero actualmente observaciones de casos, estudios clínicos y electrofisiológicos sugieren un rol crítico en la patogénesis de la fibrilación ventricular idiopática. Estudios poblacionales establecieron asociación entre esta patente y el riesgo de muerte por eventos arrítmicos. La muerte súbita cardiaca es un problema de salud pública, anualmente causa alrededor de 350.000 muertes en Estados Unidos. Muchos casos están asociados a arritmias ventriculares, de los cuales 6-14% son en individuos sin cardiopatía estructural y está determinada por anormalidades genéticas que afectan los canales iónicos o idiopáticos como el síndrome de repolarización precoz y la fibrilación ventricular idiopática que generan el 10% de dichas muertes. La revisión aborda la fisiopatología de la RP, con el fin de comprender los mecanismos por los cuales es asociada a arritmias malignas. Además, para diferenciar este patrón de otros que también generan elevación del ST y dilucidar el enfoque y recomendaciones actuales para el diagnóstico y manejo. (DUAZARY 2013 No. 1, 41 - 50AbstractEarly repolarization is a common finding characterized by ST segment elevation, QRS slurring end in 2 or more contiguous electrocardiographic derivative. For years he was considered benign, but at present observations of cases, clinical and electrophysiological studies suggest a critical role in the pathogenesis of idiopathic ventricular fibrillation. Population studies established association between this patent and risk of death from arrhythmic events. Sudden cardiac death is a public health problem, annually causes about 350,000 deaths in America. Many cases are associated with ventricular

  1. Enfermidades diagnosticadas em bezerros na região sul do Rio Grande do Sul

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    Nathalia D. Assis-Brasil

    2013-04-01

    Full Text Available O objetivo deste estudo foi relatar a frequência das enfermidades que ocorrem em bovinos até um ano de idade na área de influência do Laboratório Regional de Diagnóstico (LRD da Faculdade de Veterinária da Universidade Federal de Pelotas (UFPel estabelecendo os principais fatores epidemiológicos associados à ocorrência dessas enfermidades. Foram revisados os protocolos de necropsias realizadas e de materiais de bovinos até um ano de idade, encaminhados ao LRD/UFPel entre 2000 e 2011. Em 35,6% dos casos, os bezerros eram de raças leiteiras e em 33,98% eram animais de raças de corte, 18,3% dos bezerros não tinham raça definida e em 12,1% dos casos não constava a raça no protocolo de necropsia. Os sistemas mais afetados foram o sistema nervoso central (22,7%, o digestivo (18,6% e o respiratório (16,8%. Os diagnósticos foram divididos por faixa etária sendo que 88 bezerros tinham 1-90 dias de idade; 42 casos corresponderam a animais de 4-6 meses; 32 casos corresponderam a bezerros com 7-9 meses e 44 eram bezerros com 10-12 meses de idade. As enfermidades mais frequentemente diagnosticadas nos bezerros de 1-90 dias foram pneumonias, malformações e encefalites/meningoencefalites com 19,3%, 15,9% e 11,3% dos casos, respectivamente. Nos bezerros com 4-6 meses de idade, as pneumonias ocorreram em 16,5% dos casos e o carbúnculo sintomático e as enterites representaram 7,1% dos diagnósticos cada. Nos bezerros de 7-9 meses, as enfermidades mais frequentes foram pneumonias e tétano com 9,3% dos casos e babesiose e parasitoses gastrintestinais com 6,2% cada. Nos bezerros de 10-12 meses a infecção por BoHV-5 representou 13,6% dos casos e as pneumonias, a raiva e as parasitoses foram observadas em 9,% dos casos cada. Com base nos resultados deste trabalho pode-se concluir que as doenças infecciosas relacionadas ao sistema respiratório foram importantes causas de mortalidade em bezerros de todas as faixas etárias na área de influ

  2. Evaluación de los efectos del tratamiento con tadalafilo sobre las funciones cerebrales, neurológicas y bioquímicas en pacientes con hiperplasia benigna de próstata y disfunción eréctil

    OpenAIRE

    Ordoño Domínguez, Felipe

    2015-01-01

    EVALUACION DE LOS EFECTOS DEL TRATAMIENTO CON TADALAFILO SOBRE LAS FUNCIONES CEREBRALES, NEUROLOGICAS Y BIOQUIMICAS EN PACIENTES CON HBP Y DISFUNCION ERECTIL. La hiperplasia prostática benigna (HBP) es una de las enfermedades benignas más comunes en el hombre y puede derivar en una hipertrofia benigna de la próstata, en una obstrucción benigna de la próstata y/o en síntomas del tracto urinario inferior (STUI). La hiperplasia benigna de próstata suele estar asociada habitualmente con disfu...

  3. Potencial terapêutico de extratos de plantas medicinais em hiperplasia benigna da próstata

    OpenAIRE

    Silva, Virgínia Eduarda Monteiro da

    2015-01-01

    Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas As doenças da próstata, tais como, a prostatite, a hiperplasia benigna da próstata e o cancro da próstata, apresentam grande relevância clínica pela alta frequência com que ocorrem no quotidiano e pelas consequências que provocam. A Fitoterapia é uma terapêutica não convencional que tem vindo, ao longo das últimas décad...

  4. Tratamiento farmacológico en la hiperplasia prostática benigna Pharmacological treatment of the benign prostatic hyperplasia

    Directory of Open Access Journals (Sweden)

    Yohani Pérez Guerra

    2011-03-01

    Full Text Available La hiperplasia prostática benigna, enfermedad común en hombres a partir de los 50 años de edad, consiste en el crecimiento benigno e incontrolado de la glándula prostática y produce diversos síntomas del tracto bajo urinario. Su agente causal multifactorial involucra fundamentalmente el incremento de la conversión de testosterona en dihidrotestosterona por acción de la 5 a-reductasa prostática, lo cual desencadena eventos que propician el incremento en el tamaño de la próstata (componente estático y el aumento del tono del músculo liso de vejiga y próstata (componente dinámico regulado por los adrenoreceptores (ADR-a1. El tratamiento farmacológico de la hiperplasia prostática benigna incluye los inhibidores de la 5a-reductasa, antagonistas de ADR-a1, su terapia combinada y la fitoterapia. El objetivo del presente trabajo fue presentar los aspectos más relevantes de la farmacología de los fármacos utilizados en el tratamiento de la hiperplasia prostática benigna y brindar elementos de su eficacia, seguridad y tolerabilidad. Para ello, se realizó una reseña de los diferentes fármacos utilizados en el tratamiento de esta afección, los que fueron clasificados de acuerdo con su mecanismo de acción. Se incluyeron productos de origen natural como los extractos lipídicos del Serenoa repens y Pygeum africanum, así como el D-004, extracto lipídico de los frutos de la Roystonea regia, que ejerce efectos beneficiosos sobre los principales factores causales de la hiperplasia prostática benigna, ya que es un inhibidor de la 5 a-reductasa prostática, un antagonista de los ADR-a1, un inhibidor de la 5-lipooxigenasa y tiene acción antioxidante, lo que evidencia un mecanismo multifactorial. Los resultados hasta el presente indican que el D-004 es seguro y bien tolerado.Benign prostatic hyperplasia is a common disease in over 50 years-old men consisting in uncontrolled and benign growth of prostatic gland that leads to lower urinary

  5. Estudio del factor de crecimiento del endotelio vascular (VEGF) y del factor de crecimiento fibroblástico básico (bFGF) en la patología benigna y maligna de la próstata.

    OpenAIRE

    Rodrigo Guanter, Vicente

    2005-01-01

    RESUMEN INTRODUCCION El PSA es el mejor marcador tumoral disponible y utilizado en la actualidad para el diagnóstico y seguimiento del tratamiento del cáncer de próstata. La discriminación entre la patología benigna y maligna de la próstata, en especial entre la hiperplasia benigna de próstata y el cáncer de próstata es crucial. Desafortunadamente, el PSA no siempre puede distinguir eficientemente entre enfermedad maligna y benigna de la próstata, especialmente en el intervalo de ...

  6. Mis-generalization: An Explanation of Observed Mal-rules.

    Science.gov (United States)

    Sleeman, D.

    Previous studies were conducted with 14- to 15-year-old students on the nature of the processes they used to solve tasks given the incorrect/buggy/mal-rules. The computer-based Leeds Modelling System (LMS) was implemented and a database of examples, correct and incorrect, or mal-rules had been established which was sufficient to diagnose the…

  7. Savoir gérer le mal

    Directory of Open Access Journals (Sweden)

    Michel Maffesoli

    2015-09-01

    Full Text Available Le sens commun, conservatoire immémorial de la sagesse humaine « sait », de savoir incorporé, que le mal, l’ombre, la mort, la douleur sont des caractéristiques essentielles de l’existence en son entièreté. Dès lors les créatures quelles qu’elles soient, sont des manifestations de la vie et, dès lors, méritent une attitude « compassionnelle », fraternelle, parce qu’ensemble elles constituent le flux vital. C’est ainsi que l’on peut comprendre l’utilité sociale de ces divers « mondes intermédiaires » que sont les croyances, religieuses ou philosophiques, au « double », au « daimon », aux esprits et autres figures tutélaires ou effrayantes. Elles aident à vivre, au jour le jour, la souffrance en la communalisant.

  8. Lipomatose simétrica benigna e pelagra, associadas ao alcoolismo Benign symmetrical lipomatosis and pellagra associated with alcoholism

    Directory of Open Access Journals (Sweden)

    Fernanda de Marca Filgueiras

    2011-12-01

    Full Text Available Paciente masculino, 42 anos, etilista crônico, apresentando quadro de tumorações em região cervical e ao redor dos ombros, lesões eritemato-violáceas, descamativas e algumas lesões bolhosas, nas áreas fotoexpostas dos membros superiores e inferiores. Baseado no quadro clínico e nos exames complementares, foi estabelecido o diagnóstico de pelagra associada à lipomatose simétrica benigna, sendo ambos os quadros justificados pelo etilismo crônico. Tratado com reposição de complexo B intravenoso e orientado quanto à importância da abstinência alcoólica, apresentou remissão completa do quadro cutâneo, porém sem alteração da lipomatose.A 42-year-old male patient, alcoholic, presented showing signs of tumors in the neck and around the shoulders, scaly, erythematous-violaceous lesions and some bullous lesions in sun-exposed areas of upper and lower limbs. Based on clinical features, laboratory tests and imaging studies we have established the diagnosis of pellagra associated with benign symmetrical lipomatosis, both justified by chronic alcoholism. Treated with intravenous B-complex and oriented about the importance of alcohol withdrawal, the patient showed complete remission of skin lesions, but with no change in the lipomatosis.

  9. Characterization and expression analysis of a maltose-utilizing (MAL) cluster in Aspergillus oryzae.

    Science.gov (United States)

    Hasegawa, Sachiko; Takizawa, Masahiro; Suyama, Haruhiko; Shintani, Takahiro; Gomi, Katsuya

    2010-01-01

    Starch and maltooligosaccharides such as maltose and maltotriose induce the production of amylolytic enzymes including alpha-amylase in Aspergillus oryzae. A transcriptional activator gene amyR, required for maltose induction of amylolytic enzymes, has been cloned and characterized. The amyR gene deletion mutant showed significantly poor growth on starch medium but normal growth on maltose medium. This indicated the existence of another maltose-utilizing system, whose expression might not be controlled by amyR. We have identified a gene cluster homologous to the MAL cluster of Saccharomyces cerevisiae in the A. oryzae genome. The cluster consists of a MAL61 homolog (designated malP), a MAL62 homolog (designated malT), and a MAL63 homolog (designated malR). Overexpression of malT in A. oryzae resulted in a significant increase in intracellular alpha-glucosidase activity, and that of malP allowed S. cerevisiaemal61Delta to grow on maltose. The expression of both malP and malT genes was highly up-regulated in the presence of maltose, but malR expressed constitutively irrespective of carbon sources. Disruption of malR resulted in the loss of malP and malT expression and thus in restricted growth on maltose medium. In addition, a malP disruptant showed a significantly reduced expression of malT and malR and exhibited a growth defect on maltose similar to the malR disruptant. These results suggest that the MAL cluster of A. oryzae is responsible for the assimilation of maltose in A. oryzae. PMID:19850146

  10. Arendt, Eichmann y la banalidad del mal

    Directory of Open Access Journals (Sweden)

    López, Marina

    2010-04-01

    Full Text Available In this text I describe the characteristics that Hannah Arendt attributes to the SS agents through the figure of Eichmann, during the German Nazi regime of the 20th century. According to this characterization, I intend to show, on the one hand, that there is not a break in Arendt’s thought on evil, i.e. from The Origins of Totalitarianism to Eichmann in Jerusalem: a report on the banality of evil, but a continuous line of thought. And, on the other hand, I try to follow the clues that Arendt gives concerning the “banality” that defines the behavior of individuals such as Eichmann. Both premises will permit me to point out what, in my understanding, the banalization of humanity implies, not only in the context of the Jewish Holocaust, but in each of the societies in which the elimination of spontaneity is a reality.

    En el texto se describen las características que Hannah Arendt, a través de la figura de Eichmann, atribuye a los agentes SS durante el régimen nazi alemán de mediados del siglo XX. Con la caracterización se persigue mostrar, en principio, que no hay una ruptura en el pensamiento de Hannah Arendt respecto a su manera de considerar el mal, desde Los orígenes del Totalitarismo hasta Eichmann en Jerusalén, un estudio sobre la banalidad del mal, sino una continuidad y, por otra parte, seguir las pistas que Arendt propone en torno a la “banalidad” que define el comportamiento de individuos como Eichmann. Ambas premisas nos permitirán poner de relieve lo que, a nuestro parecer, implica la banalización de la humanidad no sólo en el contexto del Holocausto judío, sino en cada una de las sociedades en las que la eliminación de la espontaneidad es una realidad.

  11. PENGARUH KEBUDAYAAN KONTEMPORER DALAM PERANCANGAN ARSITEKTUR MAL

    Directory of Open Access Journals (Sweden)

    Freddy H. Istanto

    2000-01-01

    Full Text Available Market is traditionally known as the place where the seller and the buyers meet. In its development, it grows to be big shopping centers and even malls. Along with it, the concept of market has also changed within this building. It is not only the place where the transaction between the sellers and the buyers happen but also it expands to be the one where each person has turned to be the "player" in the nowadays "cultural-theatre". Being the designers, the architect is challenged to respond the changing pattern in the society by making use of the building. Abstract in Bahasa Indonesia : Pasar dikenal sebagai tempat dimana penjual dan pembeli bertemu. Dalam perkembangan lebih lanjut muncul pusat-pusat pertokoan yang sangat besar sampai hadirnya shopping-mall. Di dalam bangunan inilah konsep pasar secara tradisional telah berkembang, tidak saja tempat transaksi antara penjual dan pembeli, tetapi telah melebar menjadi tempat dimana setiap individu telah menjadi "pemain" di dalam sebuah teater kebudayaan masa kini. Arsitek sebagai perancang bangunan harus menyikapi perubahan-perubahan perilaku yang terjadi di masyarakat dalam menggunakan bangunannya. Kata kunci: kebudayaan kontemporer, arsitek, arsitektur mal, kebudayaan milenium tiga.

  12. Mal de debarquement syndrome: new insights.

    Science.gov (United States)

    Cha, Yoon-Hee

    2015-04-01

    Mal de Debarquement Syndrome (MdDS) is an enigmatic neurotological disorder with high morbidity, psychosocial burden, and few treatment options. Fortunately, there has been recent growth in scientific interest in understanding the biological basis of and in treating MdDS. Recent studies using functional neuroimaging have shown increased glucose metabolism in the left entorhinal cortex (EC) and amygdala in the setting of decreased prefrontal and temporal cortex metabolism in subjects with persistent MdDS. The EC is a key player in processing and gating spatial information to be stored in the hippocampus and is a major driver of brain oscillations. A limbic focus may also be key to spontaneous MdDS-like symptoms occurring in individuals with a history of anxiety or chronic stress. Treatment with repetitive transcranial magnetic stimulation over the dorsolateral prefrontal cortex can decrease the rocking dizziness of MdDS, with successful responses associated with decreases in the coherence between brain networks with nodes in the parietal and occipital lobes. A new theory of MdDS is proposed as pathology secondary to entrainment of intrinsic brain networks driven by oscillatory motion exposure coupled with an inability to subsequently desynchronize the activity of these nodes. Future treatment strategies may be directed toward unyoking these networks. PMID:25726862

  13. Resonancia Magnética Nuclear de cráneo en primeras familias cubanas diagnosticadas con ataxia de Friedreich

    Directory of Open Access Journals (Sweden)

    Tania Cruz Mariño

    2011-01-01

    Full Text Available La ataxia de Friedreich se caracteriza por edad de comienzo antes de los 25 años, ataxia progresiva, disartria, ausencia de reflejos tendinosos profundos y alteraciones en el sentido de vibración. La presente investigación se realizó con el objetivo de describir las características imagenológicas de las estructuras del sistema nervioso central en las primeras familias cubanas diagnosticadas con la enfermedad. Mediante un equipo de 0.23 Teslas -PANORAMA-, Phylips Medical Systems, con una bobina estándar de cráneo, se obtuvieron cortes axiales de 5mm de grosor usando secuencias de FLAIR, T1 y T2, así como cortes sagitales en T1 y T2 en tres individuos con diagnóstico molecular confirmatorio de ataxia de Friedreich y seis controles saludables pareados mediante edad y sexo. Las estructuras con mayor afectación morfológica son la médula espinal cervical, el cerebelo y la protuberancia, lo cual provee evidencia in vivo de que la enfermedad conduce a atrofia de dichas estructuras.

  14. Reabilitação vestibular em pacientes idosos portadores de vertigem posicional paroxística benigna

    Directory of Open Access Journals (Sweden)

    Resende Carolina R.

    2003-01-01

    Full Text Available A Vertigem Posicional Paroxística Benigna (VPPB é um distúrbio vestibular no qual os pacientes relatam breves momentos de vertigem e/ou leve instabilidade postural, ocasionados por uma mudança brusca na movimentação cefálica ou corporal. OBJETIVO: Verificar o benefício da reabilitação vestibular, realizada em grupo, em pacientes idosos portadores de VPPB. FORMA DE ESTUDO: Clínico prospectivo. MATERIAL E MÉTODO: Foram selecionados aleatoriamente 16 pacientes portadores de VPPB, todos medicados com extrato de Gingko-biloba (40mg de 12/12h durante 30 dias. Oito deles, que formaram o Grupo Experimental, além do medicamento, foram submetidos à reabilitação vestibular e oito compuseram o Grupo Controle que não realizaram nenhum tipo de exercício. Para avaliação do benefício aplicamos a Escala de Atividades de Vida Diária e Desordens Vestibulares proposta por Cohen e Kimball. Para a análise estatística utilizamos o teste t-student. CONCLUSÃO: Nossos resultados apontaram benefício promovido pela reabilitação vestibular em grupo no tratamento de idosos portadores de VPPB; a avaliação qualitativa mostrou-se instrumento importante para a avaliação de benefício para o tratamento proposto; e a reabilitação vestibular em grupo mostrou ser uma excelente estratégia terapêutica.

  15. Effects of sodium mal-distribution on AHX thermal characteristics

    International Nuclear Information System (INIS)

    The uniform distribution of a refrigerant is very important to the heat transfer performance of heat exchangers. In particular, for a sodium-to-air heat exchanger (AHX), transferring heat from high temperature liquid metal to air, a mal-distribution of the refrigerant can cause degradation of heat transfer performance or even failure of system by unexpected sodium solidification in flow paths. However, there are little quantitative studies about the effect of maldistribution on thermal characteristics with liquid metal as a coolant. This paper discusses the effects of mal-distribution on heat transfer performance and cold-spot temperature of liquid sodium coolant at the branched tube outlet in AHX unit. The technical issues, which need to be verified for the robust AHX design regarding uniform flow distribution inside heat transfer sodium tubes, are tentatively proposed as well. In this paper, the effects of sodium mal-distribution on heat removal rate and sodium outlet temperature at the branched tubes of the AHX were quantitatively investigated and the following features were tentatively obtained - The effect of mal-distribution on the total heat removal rate is not significant. - The outlet temperature difference between low and high flow rate tubes (TNA,out) increases as the degree of mal-distribution increases. - In some conditions, the outlet temperature of branched tube reaches the sodium solidification temperature when the degree of mal-distribution increases. An important point is that the sodium mal-distribution would finally result in a system failure by unexpected sodium solidification. Therefore, the studies about the improvement of coolant distribution at the AHX unit need to be conducted by carefully considering characteristics of liquid metal coolant as a future work

  16. Histerectomía laparoscópica ambulatoria en el manejo de patología benigna ginecológica: una revisión

    Directory of Open Access Journals (Sweden)

    Javier Castro Solís

    2014-03-01

    Full Text Available Title: Outpatient laparoscopic hysterectomy for benign gynecologic disease management: an overviewObjetivo. Revisar la literatura disponible sobre la histerectomía total laparoscópica ambulatoria en el manejo de patología benigna uterina. Materiales y métodos: se realizó una búsqueda en varias bases de datos incluyendo Ovid, Medline; Md Consult, Pub Med y Scielo con las palabras clave histerectomía, total, laparoscópica, ambulatoria, benigna. La búsqueda se limitó a los últimos 24 años. Resultados: inicialmente se encontraron 62 referencias, de las cuales se seleccionaron los 41 artículos más relevantes para los objetivos de la revisión. Conclusiones: la histerectomía total laparoscópica es una técnica segura en el tratamiento de patología benigna ginecológica, el manejo ambulatorio posquirúrgico de pacientes seleccionadas sometidas a esta cirugía, no incrementa el riesgo de complicaciones y puede disminuir los costos hospitalarios. (DUAZARY 2013 No. 2, 136 - 140.AbstractObjective. Reviewing the available literatura about outpatient total laparoscopic hysterectomy for benign gynecologic disease management. Materials and methods. A search was conducted in several databases including Ovid, Medline, Md Consult, Pubmed and Scielo, with the keywords outpatient, total, laparoscopic, hysterectomy, benign. The search was limited to the last 24 years. Results. Initially found 62 references of which 42 articles were selected most relevant to the objectives of the review. Conclusions. Outpatient total laparoscopic hysterectomy is a safe procedure in the treatment of benign gynecological disease, postoperative outpatient management of selected patients undergoing this surgery does not increase the risk of complications and may decrease hospital costs.Keywords: hysterectomy; total; laparoscopic; ambulatory care.

  17. Malária grave importada: relato de caso Severe imported malaria: case report

    Directory of Open Access Journals (Sweden)

    Alessandra Alves

    2007-06-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A malária ainda representa um problema de saúde global. A forma grave da doença é causada principalmente por P. falciparum e pode cursar com complicações cerebrais, renais, pulmonares, hematológicas, circulatórias e hepáticas. O objetivo deste estudo foi relatar um caso de paciente portador de malária grave importada. RELATO DO CASO: Paciente do sexo masculino, 30 anos, pardo, filipino, marinheiro, proveniente de embarcação vinda da Nigéria, com história de dor abdominal no hipocôndrio direito, icterícia, febre e rebaixamento do nível de consciência. Os exames laboratoriais de admissão mostraram hiperbilirrubinemia de 50 mg/dL, acidose metabólica grave, trombocitopenia, creatinina de 5,6 mg/dL, leucocitose com desvio até metamielócitos. O escore APACHE II foi de 37, com risco de óbito de 88%. Durante a internação foi diagnosticada malária por P. falciparum pelo teste de gota espessa. Mesmo com tratamento antimalárico adequado, o paciente evoluiu com insuficiência renal aguda necessitando de hemodiálise e síndrome de angústia respiratória aguda (SARA, necessitando de ventilação mecânica (VM, choque refratário tratado com aminas vasoativas, além de quadro hematológico, configurando um caso grave de disfunção de múltiplos de órgãos. Ainda apresentou pneumonia associada à VM e sepse relacionada ao uso de cateteres. Após a alta hospitalar, o paciente não apresentou seqüelas cerebral, pulmonar ou renal. CONCLUSÕES: Dos critérios definidores de malária grave descritos na literatura, o paciente preenchia: insuficiência renal aguda, síndrome da angústia respiratória aguda (SARA, acidose metabólica, alteração do nível de consciência, hemoglobinúria macroscópica, hiperparasitemia e hiperbilirrubinemia, que se relaciona a uma mortalidade maior que 10%, na dependência do tratamento precoce e dos recursos disponíveis. A malária grave exige diagnóstico e tratamento

  18. Cancer de mama, patologías mamarias benignas, ingesta alimentaria, estado nutricional, factores de riesgo y tiempo de lactancia materna

    OpenAIRE

    Casado, Micaela

    2014-01-01

    Una correcta alimentación antes, durante y después de la enfermedad es esencial para mantener un adecuado estado nutricional. Objetivo: Evaluar el estado nutricional, la ingesta alimentaria, el tiempo dedicado a amamantar a sus hijos y los factores de riesgo de las mujeres con cáncer de mama y patologías mamarias benignas, en un Hospital Público de la Ciudad de Mar del Plata durante el año 2014. Materiales y métodos: El estudio seleccionado es de tipo descriptivo y de caráct...

  19. Fotovaporización con láser verde para el tratamiento de la hiperplasia benigna de próstata

    OpenAIRE

    González-Chamorro Ladrón de Guevara, Fernando

    2011-01-01

    La hiperplasia benigna de próstata (HBP) es un proceso patológico benigno de proliferación celular que lleva al crecimiento del tamaño prostático y así al aumento de resistencia de salida al flujo miccional; lo que contribuye a los síntomas del tracto urinario (STUI) de los hombres de edad avanzada. Esto produce una afectación de la calidad de vida de los pacientes que la padecen hasta, en sus casos más avanzados, precisar una sonda vesical. El tratamiento es escalonado, disponiendo en el mom...

  20. Budoucí rozvoj malé firmy

    OpenAIRE

    Vojtek, Zdeněk

    2008-01-01

    Diplomová práce se zabývá problematikou malého podnikání a možnostmi jeho zlepšení na konkrétním případě. V teoretické části autor zkoumá aspekty malých a středních podniků a jejich působení v ekonomice, postup tvorby podnikatelského plánu. V praktické části analyzuje malou firmu a aspekty zlepšení stagnující firmy. Závěrem jsou doporučení pro zlepšení a rozvoj konkrétní malé firmy.

  1. Literatura y competencia comunicativa: ¿matrimonio mal avenido?

    OpenAIRE

    Ximena Troncoso Araos

    2014-01-01

    Este artículo aborda la relación problemática entre enseñanza de la literatura y enfoque comunicacional, específicamente, entre aprender literatura y desarrollar la competencia comunicativa. A partir de esta tensión diagnosticada, surgen las preguntas: ¿es plausible enseñar literatura desarrollando a la vez competencias comunicativas?, ¿es compatible la literatura con un enfoque comunicativo? Estas interrogantes consideran una premisa: entender la literatura como dominio con características d...

  2. Quedas em idosos com Vertigem Posicional Paroxística Benigna Elderly falls associated with benign paroxysmal positional vertigo

    Directory of Open Access Journals (Sweden)

    Fernando Freitas Ganança

    2010-02-01

    Full Text Available Vertigem Posicional Paroxística Benigna (VPPB pode causar quedas, principalmente em pacientes idosos. OBJETIVO: Verificar se o número de quedas em idosos com VPPB diminui após a realização de manobras de reposicionamento de partículas (MRP. MATERIAL E MÉTODO: Estudo retrospectivo em que foram incluídos idosos com VPPB que tenham apresentado queda no último ano. Todos os pacientes submeteram-se à MRP de acordo com o canal semicircular (CSC acometido. Após a abolição da vertigem e do nistagmo de posicionamento, os pacientes foram acompanhados ao longo de 12 meses e investigados em relação ao número de quedas neste período. Para comparar o número de quedas antes e após as MRP utilizou-se avaliação estatística por meio do teste de Wilcoxon. RESULTADOS: Foram incluídos 121 pacientes. Cento e um pacientes apresentaram acometimento do CSC posterior, 16 do lateral e quatro do anterior. Verificou-se redução do número de quedas após as MRP, com diferença estatisticamente significante na amostra geral (pBenign Paroxysmal Positional Vertigo (BPPV can cause falls, especially in the elderly. AIM: to study whether or not elderly patients with BPPV have a reduction on their falls after the particle repositioning maneuver (PRM. MATERIALS AND METHODS: retrospective study including elderly with BPPV who had fall(s during the last year. All patients were submitted to the PRM according to the affected semicircular canal (SCC. After the abolition of positioning vertigo and nystagmus, the patients were submitted to a 12 month follow-up and were investigated about the number of fall(s. Wilcoxon's test was performed to compare the number of fall(s before and after 12 months of the PRM. RESULTS: One hundred and twenty one patients were included in the study. One hundred and one patients presented involvement of the posterior SCC, 16 of the lateral and four of the anterior. We noticed a reduction on the number of falls, with statistically

  3. Baitul Mal and Legal Constraint: Public Wealth Management in Malaysian Context

    Directory of Open Access Journals (Sweden)

    Bayu Taufiq Possumah

    2012-11-01

    Full Text Available Baitul-Mal is normally known as a charitable institution. This point is true because presently Baitul-Mal role is more prominent in terms of providing assistance and charitable contributions and donations to the public. In essence, the original scope of Baitul-Mal covers a wider role compared to the current concept of Baitul-Mal. If we view from the context of Baitul-Mal at the early Islam, it turns out that Baitul-Mal is the only and center for the treasury of the state, but in the Malaysian context, scope and functions of Baitul-Mal are limited by the legal constraint. This paper is aimed to analyze the legal constraint and propose some procedures to empower the function and resource mobilization of Baitul-Mal. This paper will also expose that to improve the functions it can be done by using Islamic financial instruments.

  4. El mal en el mundo de los negocios

    OpenAIRE

    Koehn, D. (Daryl)

    2001-01-01

    Los teóricos de la ética que estudian la empresa y las organizaciones generalmente atribuyen la maldad y la crueldad de los hombres de empresa bien a un fracaso del razonamiento moral o a una completa falta de imaginación empática. En este artículo se estudia el mal en el ámbito de la empresa, y se indaga sobre la posibilidad de que éste asuma en ocasiones una forma más activa y creativa. Concretamente, el mal suele identificarse con figuraciones imaginativas que tienen los sig...

  5. Epilepsia occipital benigna da infância de início precoce (tipo Panayiotopoulos: aspectos clínicos e eletrencefalográficos evolutivos em 14 crianças Early-onset benign childhood occipital epilepsy (Panayiotopoulos type: clinical and electroencephalographic features in 14 children

    Directory of Open Access Journals (Sweden)

    Lineu Correa Fonseca

    2005-06-01

    Full Text Available Foram estudadas as características evolutivas clínico-eletrencefalográficas de 14 crianças com epilepsia occipital benigna da infância de início precoce (tipo Panayiotopoulos. O tempo médio de segmento foi 50,5 meses. A idade média na primeira crise foi 3,7 anos. O número total de crises foi até 3 crises em 11 casos, numerosas em 3; o período médio entre a primeira e a última crise foi 14,5 meses. Em 4 casos as crises tiveram duração prolongada, constituindo estado de mal parcial. Atividade epileptiforme (AE occipital foi observada em todos os casos no primeiro EEG e, foi também, extra-occipital, em 3 casos. Houve bloqueio da AE occipital, pela abertura dos olhos, em 4 casos; em 3 casos foram observadas, também, pontas evocadas. O EEG normalizou-se em 9 casos, em um período médio de 29 meses.We studied clinical and electroencephalographic features of 14 children, age range of 2 -8 years, with no neurological or neuroradiological evidence of brain damage and with occipital epileptiform activity in the EEG. Seizures were numerous in 3 cases. Age at onset was between 1-7 years. In 4 cases the seizures last for more than 20 min. Spikes were observed in 6 cases and spike and slow-wave complex in 8. Discharges blocking by eyes opening were confirmed in 4 cases. Somatosensory evoked spikes by foot stimulation were observed in 2 cases. Autonomic and versive seizures are the main clinical manifestations of Panayiotopoulos syndrome. Discharges blocking by eyes opening are a less frequent feature.

  6. Síndrome de Brown bilateral associada com hipermobilidade articular benigna: relato de caso Bilateral Brown's syndrome associated with benign joint hypermobility: a case report

    Directory of Open Access Journals (Sweden)

    David Kirsch

    2007-03-01

    Full Text Available A síndrome de Brown é caracterizada por grande limitação de elevação em adução, elevação ligeiramente diminuída ou normal na abdução, anisotropia em "Y" ou "V", intorção do olho em supraversão e ducção forçada positiva. Sua causa se deve à inelastibilidade do músculo oblíquo superior ou por sua contenção em sua própria bainha. A hipermobilidade articular benigna é doença hereditária do tecido conectivo caracterizada por aumento da mobilidade em diversas articulações. Sua prevalência é muito variável em relação à idade, sexo e etnia, variando de 2 a 35% em homens e de 5 a 57% e mulheres. Neste relato os autores descrevem um caso de síndrome de Brown associada com hipermobilidade articular benigna e atentam para a associação pouco referida na literatura. J.C.S, masculino, 6 anos de idade, pardo, estudante, foi encaminhado à Universidade de Santo Amaro com queixa de exotropia há dois anos que aumentava na supraversão. Paciente com o diagnóstico de síndrome de Brown bilateral teve o diagnóstico de hipermobilidade articular benigna pelo Reumatologista. O paciente com hipermobilidade articular benigna pode desenvolver sintomas articulares como artralgia devido a uma inflamação articular. Acreditamos na possibilidade de que síndrome de Brown possa ter ocorrido devido a processo inflamatório na tróclea que teve início devido a hipermobilidade articular benigna.Brown's syndrome is characterized by a limitation of elevation in adduction, slight or normal limitation of elevation in abduction, divergence in straight upgaze (V-pattern, intorsion in upgaze and positive forced duction. It is caused by a tight or inelastic superior oblique tendon. Benign joint hypermobility is a hereditary disease of the connective tissue characterized by an increase of mobility in diverse joints. Its prevalence is very changeable regarding age range, sex and ethnicity, varying from 2 to 35% in men and 5 to 57% in women. In

  7. The N Terminus of the Escherichia coli Transcription Activator MalT Is the Domain of Interaction with MalY

    OpenAIRE

    Schlegel, Anja; Danot, Olivier; Richet, Evelyne; Ferenci, Thomas; Boos, Winfried

    2002-01-01

    The maltose system of Escherichia coli consists of a number of genes encoding proteins involved in the uptake and metabolism of maltose and maltodextrins. The system is positively regulated by MalT, its transcriptional activator. MalT activity is controlled by two regulatory circuits: a positive one with maltotriose as effector and a negative one involving several proteins. MalK, the ATP-hydrolyzing subunit of the cognate ABC transporter, MalY, an enzyme with the activity of a cystathionase, ...

  8. Acción de Finasteride sobre el volumen prostático en caninos con hiperplasia prostática benigna

    OpenAIRE

    Stornelli, María Alejandra; Stornelli, María Cecilia; Rodríguez, R.; Scodellaro, Carla Floriana; Savignone, César A.

    2002-01-01

    Se administró 0,1 mg/kg día de Finasteride, inhibidor selectivo de la 5 αreductasa, vía oral a caninos machos adultos con diferentes grados de hiperplasia prostática benigna. Se evaluó, mediante ecografía, el efecto de la droga sobre el tamaño prostático. Finasteride provocó importante disminución del tamaño glandular y no se asoció a efectos tóxicos colaterales. La dosis utilizada fue 10 veces inferior a la utilizada por otros autores, sin embargo se lograron resultados similares a los obten...

  9. Tratamento conservador das estenoses benignas do esôfago através de dilatações. Análise de 500 casos

    OpenAIRE

    Andreollo, N A; LOPES L.R.; INOGUTTI R.; BRANDALISE N. A.; L. S. LEONARDI

    2001-01-01

    As estenoses benignas do esôfago (EBE) são complicações muito freqüentes, resultado de várias etiologias, a saber: refluxo gastro-esofágico, ingestão de agentes corrosivos, pós-cirurgias do esôfago, pós-radioterapia no tórax, pós-escleroterapia endoscópica de varizes do esôfago, ingestão de medicamentos, uso prolongado de cateter nasogástrico, compressão extrínseca e membranas esofágicas congênitas. As dilatações esofágicas são recomendadas no tratamento dessa complicação, empregando dilatado...

  10. Integrating electrodermal biofeedback into pharmacologic treatment of grand mal seizures

    OpenAIRE

    Tullio Michele Scrimali; Massimo Sciuto

    2015-01-01

    Electrodermal activity (EDA) and electrodermal biofeedback, when integrated with pharmacologic treatments, indicate promising methods for the treatment of grand mal seizures. They can be used to monitor patient arousal and help patients learn new strategies to better cope with stress and anxiety. Our proposed method can possibly reduce the number of crises for patients who are dependent on pharmacologic therapy and can improve their quality of life. This article describes the scientific backg...

  11. Integrating electrodermal biofeedback into pharmacologic treatment of grand mal seizures.

    Science.gov (United States)

    Scrimali, Tullio; Tomasello, Damiana; Sciuto, Massimo

    2015-01-01

    Electrodermal activity (EDA) and electrodermal biofeedback, when integrated with pharmacologic treatments, indicate promising methods for the treatment of grand mal seizures. They can be used to monitor patient arousal and help patients learn new strategies to better cope with stress and anxiety. Our proposed method can possibly reduce the number of crises for patients who are dependent on pharmacologic therapy and can improve their quality of life. This article describes the scientific background of electrodermal monitoring and electrodermal biofeedback for patients affected by grand mal seizures. In this study, we have reported a clinical case study. The patient was treated for 2 years with electrodermal biofeedback to augment pharmacologic treatments. The trial has been designed in accordance with "n = 1 case study research". Our results have shown that our methods could achieve a significant reduction in grand mal seizures and sympathetic arousal when applied. The patient under consideration was also relaxed and exhibited greater competency to cope with stress. Additionally, the patient's sense of mastery and self-efficacy was enhanced. PMID:26029078

  12. Electroencephalogram Signals Processing for the Diagnosis of Petit mal and Grand mal Epilepsies Using an Artificial Neural Network

    Directory of Open Access Journals (Sweden)

    M. R. Arab

    2010-04-01

    Full Text Available In this study, a novel wavelet transform‐neural network method is presented. The presented method is used for theclassification of grand mal (clonic stage and petit mal (absence epilepsies into healthy, ictal and interictal (EEGs. Preprocessingis included to remove an artifact occurred by blinking and a wandering baseline (electrodes movement as well as an eyeballmovement artifact using the Discrete Wavelet Transformation (DWT. Denoising EEG signals from the AC power supplyfrequency with a suitable notch filter is another job of preprocessing. The preprocessing enhanced speed and accuracy of theprocessing stage (wavelet transform and neural network. The EEGs signals are categorized into normal and petit mal and clonicepilepsy by an expert neurologist. The categorization is confirmed by the Fast Fourier Transform (FFT analysis. The datasetincludes waves such as sharp, spike and spike‐slow wave. Through the Countinous Wavelet Transform (CWT of EEG records,transient features are accurately captured and separated and used as classifier input. We introduce a two‐stage classifier basedon the Learning Vector Quantization (LVQ neural network localized in both time and frequency contexts. The particularcoefficients of the Continuous Wavelet Transform (CWT are networks. The simulation results are very promising and theaccuracy of the proposed method obtained is of about 80%.

  13. Polirradiculoneurite e malária: relato de um caso

    Directory of Open Access Journals (Sweden)

    Carlos A. M. Guerreiro

    1985-06-01

    Full Text Available Registro de caso de paciente que três semanas após malária por Plasmodium falciparum desenvolveu forma severa de polirradiculoneurite, com tetraplegia e comprometimento de vários nervos cranianos (VI, VII, IX, X, evoluindo para a morte. A síndrome de Guillain-Barré tem sido considerada desordem imune relacionada a diversos estímulos antigênicos desencadeantes. O caso registrado sugere que protozoários podem ser um desses fatores antigênicos.

  14. Polirradiculoneurite e malária: relato de um caso

    OpenAIRE

    Carlos A. M. Guerreiro; Nubor O. Facure; Fernando L. Gonçalves Junior; Luiz Jacintho da Silva; Marcelo de Carvalho Ramos; Rogério de Jesus Pedro

    1985-01-01

    Registro de caso de paciente que três semanas após malária por Plasmodium falciparum desenvolveu forma severa de polirradiculoneurite, com tetraplegia e comprometimento de vários nervos cranianos (VI, VII, IX, X), evoluindo para a morte. A síndrome de Guillain-Barré tem sido considerada desordem imune relacionada a diversos estímulos antigênicos desencadeantes. O caso registrado sugere que protozoários podem ser um desses fatores antigênicos.

  15. The malQ gene is essential for starch metabolism in Streptococcus mutans

    Directory of Open Access Journals (Sweden)

    Yutaka Sato

    2013-08-01

    Full Text Available Background: The malQ and glgP genes, respectively, annotated as putative 4-α-glucanotransferase and putative glycogen phosphorylase are located with a 29 nucleotide overlap on the Streptococcus mutans genome. We found that the glgP gene of this organism was induced with maltose, and the gene likely constituted an operon with the upstream gene malQ. This putative operon was negatively regulated with the malR gene located upstream from the malQ gene and a MalR-binding consensus sequence was found upstream of the malQ gene. S. mutans is not able to catabolize starch. However, this organism utilizes maltose degraded from starch in the presence of saliva amylase. Therefore, we hypothesized that the MalQ/GlgP system may participate in the metabolism of starch-degradation products. Methods: A DNA fragment amplified from the malQ or glgP gene overexpressed His-tagged proteins with the plasmid pBAD/HisA. S. mutans malQ and/or glgP mutants were also constructed. Purified proteins were assayed for glucose-releasing and phosphorylase activities with appropriate buffers containing maltose, maltotriose, maltodextrin, or amylodextrin as a substrate, and were photometrically assayed with a glucose-6-phosphate dehydrogenase–NADP system. Results: Purified MalQ protein released glucose from maltose and maltotriose but did not from either maltodextrin or amylodextrin. The purified GlgP protein did not exhibit a phosphorylase reaction with maltose or maltotriose but generated glucose-1-phosphate from maltodextrin and amylodextrin. However, the GlgP protein released glucose-1-phosphate from maltose and maltotriose in the presence of the MalQ protein. In addition, the MalQ enzyme activity with maltose released not only glucose but also produced maltooligosaccharides as substrates for the GlgP protein. Conclusion: These results suggest that the malQ gene encodes 4-α-glucanotransferase but not α-1,4-glucosidase activity. The malQ mutant could not grow in the

  16. AS DUAS FACES DO MAL: COMUNISMO E NAZISMO

    Directory of Open Access Journals (Sweden)

    José João Neves Barbosa Vicente

    2012-07-01

    Full Text Available Resumo: em Origens do totalitarismo, publicada em 1951, Arendt pensa o grande mal do século XX: o fenômeno totalitário como destruição da pluralidade humana, negação da semelhança dos homens e da sua pertença a uma mesma humanidade. Esse mal, para ela, reduz-se a dois regimes: o nazismo de Hitler e o comunismo de Stalin. A proposta deste artigo é analisar as características comuns entre esses dois regimes como descritas por ArendtAbstract: In The origins of totalitarianism, published in 1951, Arendt thinks the great evil of 20th century: the totalitarian phenomenon as destruction of the human plurality, negation of the similarity of the men and they belong to the same humanity. This evil, for she is reduced to two regimes: the Nazism of Hitler and the communism of Stalin. The proposal of this paper is to analyze the common characteristics between these two regimes as described by Arendt.

  17. Interní audit v malé organizaci.

    OpenAIRE

    Obůrka, Miloš

    2008-01-01

    Účelem této bakalářské práce bylo zpracovat literární rešerši na téma interní audit v malé organizaci a z takto provedeného průzkumu vyvodit vlastní závěry. Obsahuje seznámení s průběhem auditů se zaměřením na interní audity včetně specifických odlišností auditování v malých organizacích. Vytváří přehled současného stavu interních auditů s výhledem na budoucí koncept auditů. The purpose of this bachelor thesis was the elaboration of the literary recherché on the topic of internal auditing ...

  18. Epigenetic silencing of MAL, a putative tumor suppressor gene, can contribute to human epithelium cell carcinoma

    Directory of Open Access Journals (Sweden)

    Zhang Jun

    2010-11-01

    Full Text Available Abstract Background To identify new and useful candidate biomarkers in head and neck squamous cell carcinoma (HNSCC, we performed a genome-wide survey and found that Myelin and lymphocyte-associated protein (MAL was a gene that was markedly down-regulated in HNSCC. Hence, we investigated the mechanism of MAL silencing and the effects of MAL on the proliferation, invasion, and apoptotic potential in HNSCC. Results MAL was significantly down-regulated in 91.7% of HNSCC specimens at the mRNA level as compared with adjacent normal tissues (P = 0.0004. Moreover, the relative transcript levels of the MAL gene were remarkably decreased by five-fold in nine HNSCC cell lines as compared with normal head and neck epithelium cells. MAL gene expression was restored in 44%, 67%, and 89% in HNSCC cell lines treated with TSA, 5-Aza-dC, and TSA plus 5-Aza-dC, respectively. Furthermore, bisulfate-treated DNA sequencing demonstrated that the two CpG islands (that is, M1 and M2 located in MAL promoter region were completely methylated in the HNSCC cell lines (CpG methylated ratio was more than 90%, and only one CpG island (that is, M1 was partially methylated in HNSCC tissues (CpG methylated ratio between 20% and 90%. A significant reduction in cell proliferation and a change in the cell cycle profile were also observed in MAL transfectants. Matrigel assay demonstrated that the invasiveness of HNSCC cells significantly decreased. A significant increase in the population of apoptotic cells was observed in MAL transfected cells. The exogenous expression of the MAL gene suppressed malignant phenotypes, while the cell death induced by MAL gene transfer was a result of apoptosis as demonstrated by the induction of cleavage of the poly (that is, ADP-ribose polymerase. Additionally, tumor growth was suppressed in cells expressing MAL as compared with cells not expressing MAL. Conclusion Our data suggest that the epigenetic inactivation of MAL, as a candidate tumor

  19. O mal, sentido e dito Badness felt and spoken

    Directory of Open Access Journals (Sweden)

    Daniel Delouya

    2005-08-01

    Full Text Available O questionamento por que o mal é tão antigo quanto a linguagem e a humanidade. A definição e a identificação do mal com o outro constituem o eixo mais conhecido nas ocupações filosóficas e psicanalíticas. As inabilidades do ser humano, desde os inícios da vida, em lidar com as intensidades que se abatem sobre ele de dentro e de fora, e que resultam no que se denomina de trauma, são certamente os fatores da apreensão do mal e sua identificação com o outro. Entretanto, o trauma institui também o outro na origem do próprio desejo e como guia para a própria linguagem. O outro se engaja nesta empreitada pelo apelo imanente ao trauma e ao estado de desamparo do sujeito. Pretendemos "puxar" um dos fios deste arranjo paradoxal na obra freudiana, examinando sua atual relevância no cenário social e político, também a partir de obras pós-freudianas.The questioning is why badness is as old as humanity and language. The definition and identification of badness with the Other constitute one of the main known axes around which philosophical and psychoanalytical thoughts were fabricated. The helplessness of the newborn human being, his inability to deal with the outer and inner intensities and exigencies, that is, the trauma impact of existence, is certainly one of the main factors for badness conception and the perception of its origin in the other. However, psychoanalysis shows us beyond doubt that the other is also the traumatic source of the human desire and language. The other is called to exercise these functions by the immanent necessities of the original traumatic human condition. We examine some aspects of this paradox complex following its indications in the first Freudian works and relating it to post-Freudian works and its relation with the contemporary scenario

  20. [Clonage of the "malA" region of "Escherichia coli" K12: nucleotide sequence of the regulatory region and the promoters, identification and purification of the MalT-activator protein (author's transl)].

    Science.gov (United States)

    Raibaud, O; Débarbouillé, M; Cossart, P

    1982-01-01

    A 5,800-bp (base pair) HindIII-EcoRI DNA fragment containing malT, the positive regulator gene of the maltose regulon, and most of malP, the structural gene for maltodextrin phosphorylase, was cloned into pBR322. A sequence of 802 bp was established in a DNA segment containing the promotor for malPQ and the promoter for malT. A total of 611 bp separates the initiation codons for these two genes, which are transcribed in opposite directions. The malT product was identified as a 94,000 dalton polypeptide. PMID:6462088

  1. Literatura y competencia comunicativa: ¿matrimonio mal avenido?

    Directory of Open Access Journals (Sweden)

    Ximena Troncoso Araos

    2014-12-01

    Full Text Available Este artículo aborda la relación problemática entre enseñanza de la literatura y enfoque comunicacional, específicamente, entre aprender literatura y desarrollar la competencia comunicativa. A partir de esta tensión diagnosticada, surgen las preguntas: ¿es plausible enseñar literatura desarrollando a la vez competencias comunicativas?, ¿es compatible la literatura con un enfoque comunicativo? Estas interrogantes consideran una premisa: entender la literatura como dominio con características diferenciales. Luego, se somete a prueba, desde una perspectiva literaria y didáctica, la hipótesis que es posible desarrollar competencia comunicativa sin descuidar la especificidad y potencialidad de la literatura. Para ello, se analizan diversos textos en relación con cuatro subcompetencias: léxico-semántica, textual, discursiva y sociocognitiva. Si bien una misma obra podría analizarse en función de todas estas subcompetencias, se consideran por separado para efectos de la investigación. El análisis contempla textos principalmente narrativos y algunos líricos, sin distinción de edad. Esto evidencia que es factible desarrollar las subcompetencias en distintos niveles educacionales, aunque regulando la pertinencia de los textos y el tratamiento didáctico. En términos globales, se concluye que es posible compatibilizar competencia comunicativa y literatura considerando los énfasis específicos de lo literario y sus consecuentes derivaciones didácticas.

  2. Malý hydraulický lis na biobrikety

    OpenAIRE

    Kadlec, Martin

    2012-01-01

    Cílem této diplomové práce je konstrukční návrh malého hydraulického lisu na biobrikety s předem danými parametry. V teoretické části je přehled současného stavu v podobě zpracování biomasy, výroby briket a popis briketovacích lisů. Praktická část se zabývá variantami řešení a podrobným konstrukčním řešením vybrané varianty. Modely a výkresy jsou zpracovány v programu SolidWorks 2011.

  3. Fernandez osteotomy of radio distal with mal united fracture

    International Nuclear Information System (INIS)

    We review prospectively our experience in the military hospital in Bogota, Colombia, with the opening-wedge osteotomy for the treatment of a mal united fracture of the distal end of the radius in fifty-six consecutive patients from 1990 to 2002. The indications for operation were pain predominantly in the radio-ulnar joint and functional limitation with grip strength loss. Preoperative radiographs revealed an average ulnar inclination of 14 degrees, an average ulnar variance of four millimeters, and increased dorsal tilt (colles deformity) that averaged 28 degrees. All patients had limited function. The average grip strength was a force of fifteen kilograms compared with a force of thirty-one kilograms in the contralateral hand. Postoperatively, all of the patients had substantial improvement in function, relief of pain and grip strength increased. The functional results were rated as very good in eleven patients, good in thirty-six, fair in nine

  4. Cochlear implantation in a patient with grand mal epilepsy.

    Science.gov (United States)

    Szilvassy, J; Czigner, J; Somogyi, I; Jori, J; Kiss, J G; Szilvassy, Z

    1998-06-01

    A case is reported in which a Nucleus 22 channel intracochlear implant was used to treat a deaf Hungarian woman (aged 37 years) with a 34-year history of grand mal (GM) epilepsy maintained on carbamazepine-diazepam combination therapy who had not benefited from conventional hearing aids. Pre-operative electrical stimulation of the acoustic nerve, however, exhibited a good nerve function with no evidence of abnormal waveforms in the electroencephalogram (EEG). Successful intracochlear insertion of the 22 electrode resulted in a 40 dB hearing improvement at frequencies 250-2000 Hz in the implanted ear with no signs of pathologic wave activity at either the previously recognized epileptic focus (fronto-precentral region) or indeed, in other regions of the brain at use of the implant. We conclude that intracochlear implantation per se is not a hazardous intervention in patients with fronto-precentral epileptic foci. PMID:9764299

  5. MalY of Escherichia coli is an enzyme with the activity of a beta C-S lyase (cystathionase).

    OpenAIRE

    Zdych, E; Peist, R; Reidl, J.; Boos, W

    1995-01-01

    The Escherichia coli maltose system consists of a number of genes whose products are involved in the uptake and metabolism of maltose and maltodextrins. MalT is the central positive gene activator of the regulon and is, together with the cyclic AMP-catabolite gene activator protein system, necessary for the expression of the maltose genes. Expression of malY, a MalT-independent gene, leads to the repression of all MalT-dependent genes. We have purified MalY to homogeneity and found it to be a...

  6. Transcription of malP is subject to phosphotransferase system-dependent regulation in Corynebacterium glutamicum.

    Science.gov (United States)

    Kuhlmann, Nora; Petrov, Dimitar P; Henrich, Alexander W; Lindner, Steffen N; Wendisch, Volker F; Seibold, Gerd M

    2015-09-01

    The Gram-positive Corynebacterium glutamicum co-metabolizes most carbon sources such as the phosphotransferase system (PTS) sugar glucose and the non-PTS sugar maltose. Maltose is taken up via the ABC-transporter MusEFGK2I, and is further metabolized to glucose phosphate by amylomaltase MalQ, maltodextrin phosphorylase MalP, glucokinase Glk and phosophoglucomutase Pgm. Surprisingly, growth of C. glutamicum strains lacking the general PTS components EI or HPr was strongly impaired on the non-PTS sugar maltose. Complementation experiments showed that a functional PTS phosphorelay is required for optimal growth of C. glutamicum on maltose, implying its involvement in the control of maltose metabolism and/or uptake. To identify the target of this PTS-dependent control, transport measurements with 14C-labelled maltose, Northern blot analyses and enzyme assays were performed. The activities of the maltose transporter and enzymes MalQ, Pgm and GlK were not decreased in PTS-deficient C. glutamicum strains, which was corroborated by comparable transcript amounts of musE, musK and musG, as well as of malQ, in C. glutamicum ΔptsH and WT. By contrast, MalP activity was significantly reduced and only residual amounts of malP transcripts were detected in C. glutamicum ΔptsH when compared to WT. Promoter activity assays with the malP promoter in C. glutamicum ΔptsH and WT confirmed that malP transcription is reduced in the PTS-deficient strain. Taken together, we show here for what is to the best of our knowledge the first time a regulatory function of the PTS in C. glutamicum and identify malP transcription as its target. PMID:26296766

  7. Diagnóstico tardio de malária em área endêmica de dengue na extra-Amazônia Brasileira: experiência recente de uma unidade sentinela no estado do Rio de Janeiro Delayed diagnosis of malaria in a dengue endemic area in the Brazilian extra-Amazon: recent experience of a malaria surveillance unit in state of Rio de Janeiro

    Directory of Open Access Journals (Sweden)

    Anielle de Pina Costa

    2010-10-01

    Full Text Available INTRODUÇÃO: A letalidade da malária na região extra-amazônica é cerca de 80 vezes maior do que na Amazônia, que concentra 99,8% dos casos do país. Em áreas de transmissão de dengue, como o Rio de Janeiro, o atraso no diagnóstico e tratamento da malária dos pacientes com febre, provenientes de áreas endêmicas de malária, pode ser, entre outros fatores, devido à confusão entre o diagnóstico das duas doenças pelos generalistas da rede de assistência médica. Neste trabalho, apresentamos as consequências do atraso diagnóstico em três pacientes com malária por Plasmodium falciparum; P. malariae e P. vivax, que, após o périplo habitual para tratamento de dengue, procuraram a nossa instituição onde foram corretamente diagnosticados e submetidos aos tratamentos adequados. MÉTODOS: Descrição de três casos de malária diagnosticada tardiamente e encaminhados ao IPEC/ FIOCRUZ, entre os anos de 2007 e 2008. RESULTADOS: uma brasileira proveniente de Moçambique, primo-infectada por P. falciparum, com malária diagnosticada após 6 dias do início da febre, morreu com malária cerebral e choque. Outro paciente com malária por P. malariae teve um curso grave e prolongado, mas ficou curado após o tratamento específico. A terceira paciente diagnosticada tardiamente apresentou malária por P. vivax adquirida na região de Mata Atlântica no Estado do Rio. CONCLUSÕES: Os profissionais de saúde do Rio devem ser treinados para aperfeiçoar a vigilância e o tratamento oportuno da malária e evitar desfechos mórbidos e fatais. Sugere-se que uma investigação de focos de malária autóctone em áreas de mata no estado seja realizada.INTRODUCTION: The mortality of malaria in the extra-Amazon region is about 80 times higher than in the Amazon region, where malaria is concentrated (99.8% of cases. In areas of dengue transmission, delay in the diagnosis and treatment of malaria in patients with fever who reside in areas of malaria

  8. Glucose and maltose metabolism in MIG1-disrupted and MAL-constitutive strains of Saccharomyces cerevisiae

    DEFF Research Database (Denmark)

    Klein, Christopher; Olsson, Lisbeth; Rønnow, B; Mikkelsen, Jørn Dalgaard; Nielsen, Jens Bredal

    1997-01-01

    The alleviation of glucose control of maltose metabolism brought about by MIG1 disruption was compared to that by MAL overexpression in a haploid Saccharomyces cerevisiae strain. The sugar consumption profiles during cultivation of the wild type, single transformants and a double transformant in a...... mixed glucose-maltose medium revealed that the MAL-constitutive strains were more alleviated than the single MIG1-disrupted transformant. While all transformants exhibited higher maximum specific growth rates (0.24-0.25 h(-1)) in glucose-maltose mixtures than the wild type strain (0.20 h(-1)), the MAL...

  9. Embolização das artérias prostáticas no tratamento da hiperplasia benigna da próstata : estudo anátomo-clínico

    OpenAIRE

    Bilhim, Tiago Campos Andrada de Faria

    2011-01-01

    Resumo: A hiperplasia benigna da próstata (HBP) tem elevada prevalência nos homens entre os 50 e 79 anos de idade, sendo ubiquitária com o envelhecimento. Devido à significativa morbi-mortalidade associada aos tratamentos médicos e cirúrgicos currentemente disponíveis, são necessárias novas tecnologias para melhorar os resultados e minimizar o desconforto dos doentes. Recentemente, estudos preliminares de experimentação animal e em 3 doentes tratados, sugeriram a embolização arter...

  10. Hannah Arendt: o mal banal e o julgar = Hannah Arendt: banal evil and the judgment

    Directory of Open Access Journals (Sweden)

    Schio, Sônia Maria

    2011-01-01

    Full Text Available Hannah Arendt escreveu que o “mal banal” origina-se da incapacidade do indivíduo para pensar. Porém, pode-se perguntar se o mal não pode se originar da falta de julgamento. Ou seja, o indivíduo comete atos maus porque não averigua os dados, não os avalia. Em tal hipótese, o “mal banal” ocorre devido à ausência do “juízo reflexionante” (ou reflexivo e da “mentalidade alargada” kantianos, resolvendo muitas das lacunas que o mal derivado do pensamento possui, como a que exige distinguir o raciocínio do pensamento.

  11. Estados de mal epiléptico na sindrome Delennox-Gastaut: aspectos terapeuticos

    Directory of Open Access Journals (Sweden)

    José Geraldo Speciali

    1977-09-01

    Full Text Available Foram descritas as condutas terapêuticas utilizadas nos estados de mal epiléptico, convulsivos e não convulsivos, observados em 14 pacientes com síndrome de Lennox-Gastaut. Verificou-se relação temporal entre aparecimento de estado de mal epiléptico e início de tratamento com clonazepam e difenilhidantoina; a retirada dessas medicações foi seguida pelo desaparecimento dos estados de mal. Indicou-se a possibilidade de tratamento dos estados de mal epiléptico modificando-se o esquema terapêutico administrado por via oral, reservando-se o tratamento parenteral para os estados com comprometimento progressivo da consciência e/ou dos distúrbios neurovegetativos.

  12. "Kevad uhkelt sammub mal kui jumalanna..." : [luuletused] / Ljubov Dergatshova ; tlk. Arvo Valton

    Index Scriptorium Estoniae

    Dergatshova, Ljubov

    2006-01-01

    Sisu: "Kevad uhkelt sammub mal kui jumalanna..." ; "Maga, pojake, maga mu päike..." ; "Mis kaunis õhtu! Lumi tahke..." ; "Raskel tunnil sirutab kes käe...". Luuletused paralleelselt ersa ja eesti keeles

  13. Physiological function of the maltose operon regulator, MalR, in Lactococcus lactis

    OpenAIRE

    Rådström Peter; Andersson Ulrika

    2002-01-01

    Abstract Background Maltose metabolism is initiated by an ATP-dependent permease system in Lactococcus lactis. The subsequent degradation of intracellular maltose is performed by the concerted action of Pi-dependent maltose phosphorylase and β-phosphoglucomutase. In some Gram-positive bacteria, maltose metabolism is regulated by a maltose operon regulator (MalR), belonging to the LacI-GalR family of transcriptional regulators. A gene presumed to encode MalR has been found directly downstream ...

  14. Mal de Meleda with Lip Involvement: A Report of Two Cases

    OpenAIRE

    Amiya Kumar Nath; Sangita Chaudhuri; Devinder Mohan Thappa

    2012-01-01

    Mal de Meleda is a rare autosomal recessive transgradient palmoplantar keratoderma characterized by transgradient keratoderma with associated scleroatrophy, nail changes, pseudoainhum around digits and perioral erythema, without a tendency for spontaneous resolution. Involvement of the lip by keratoderma has not been reported in the English literature. Here we present two cases of Mal de Meleda with unusual lip involvement. The first case was a 15-year-old girl, born of second-degree consangu...

  15. X-ray structure of MalY from Escherichia coli: a pyridoxal 5′-phosphate-dependent enzyme acting as a modulator in mal gene expression

    OpenAIRE

    Clausen, Tim; Schlegel, Anja; Peist, Ralf; Schneider, Eva; Steegborn, Clemens; Chang, Yuh-Shin; Haase, Andrea; Bourenkov, Gleb P.; Bartunik, Hans D.; Boos, Winfried

    2000-01-01

    MalY represents a bifunctional pyridoxal 5′-phosphate-dependent enzyme acting as a β–cystathionase and as a repressor of the maltose regulon. Here we present the crystal structures of wild-type and A221V mutant protein. Each subunit of the MalY dimer is composed of a large pyridoxal 5′-phosphate-binding domain and a small domain similar to aminotransferases. The structural alignment with related enzymes identifies residues that are generally responsible for β–lyase activity and depicts a uniq...

  16. BAYT AL-MAL AND ITS ROLE IN ECONOMIC DEVELOPMENT: A CONTEMPORARY STUDY

    Directory of Open Access Journals (Sweden)

    Md. Habibur RAHMAN

    2015-08-01

    Full Text Available Bayt al-Mal, known as the public treasury of Islamic state, was established by the Prophet-may peace be upon Him- and then it was further extended and expanded by Abu Bakr and Umar, who succeeded the Prophet as the Caliph of the Islamic state. It is the state treasury that keeps the sole authority to mobilize the funds of the state. This paper aims to study the potential role and contribution of Bayt al-Mal to economic development in the contemporary context. It will be a qualitative paper and the analytical and descriptive method will be applied. Historically Bayt al-Mal played a great role in the distribution and redistribution of funds. It performed the function that is similar to the function of the ministry of finance at present. It also carried out the jobs of central bank in terms of monitoring, issuing currencies, controlling credits and so forth. Through discussing its sources and expenditures the paper posits that the role of Bayt al-Mal can be revived and accelerated by, for example, providing small-medium funds, managing Zakah and awqaf, channeling the funds, issuing various financial instruments and so forth. Bayt al-Mal could have a significant role in the eradication of poverty from the state. The paper concludes that with the rapid growth of Islamic finance, the Bayt al-Mal can be utilized in parallel in order to have a robust economic development.

  17. Eplepsia benigna da infância com pontas centrotemporais: foco central alto ou baixo Benign childhood epilepsy with centrotemporal spikes: high and low central focus

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    Marcos H. Coelho Duran

    2003-12-01

    Full Text Available Foram selecionadas 20 crianças com diagnóstico de epilepsia benigna da infância com pontas centrotemporais. Realizou-se anamnese, exame neurológico, aplicação da Escala de Maturidade Mental'' Columbia'' (1993 e eletrencefalograma digital. (EEG O EEG digital foi gravado com eletrodos de acordo com o sistema internacional 10-20, acrescido de um eletrodo suplementar entre o eletrodos C3 eT3 ou C4 e T4 no lado onde ocorreu o maior número de pontas. Foi realizada a promediação dessas descargas para análise do local de máxima negatividade. A ocorrência de crises envolvendo um membro superior foi proporcionalmente maior nos sujeitos com pontas de máxima negatividade em C3, C4 do que em C5, C6, T3 ou T4. A atividade epileptiforme não centrotemporal associada foi mais frequente nos sujeitos com descargas centrotemporais de máxima negatividade em C3 e C4. Esse estudo demonstra a existência de diferenças clínicas e eletrencefalográficas de acordo com a localização das descargas centrotemporais.Twenty children with benign childhood epilepsy with centrotemporal spikes were studied. Anamnesis, neurological exam, ''Columbia'' Scale (1993 application and digital electroencephalogram were carried out. The digital electroencephalogram was recorded with electrodes according to 10-20 international system, and a supplementary electrode, between C3 and T3 or C4 and T4 - C5 or C6, respectively, at the side with a higher number of spikes. The averaging of the spikes was carried. Localization and the laterality of the spikes were analyzed. Seizures involving a superior limb occurred in a higher proportion of cases with spikes of maximum negativity in C3, C4. Independent epileptiform activity, different from centrotemporal, was more frequent in the cases were the maximum negativity of the spikes occurred in C3 or C4 regions. There are clinical and electroencephalographic differences according to the localization of the discharges

  18. Benign paroxysmal positional vertigo recurrence and persistence Recorrência e persistência da vertigem posicional paroxística benigna

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    Ricardo S Dorigueto

    2009-08-01

    Full Text Available Benign paroxysmal positional vertigo (BPPV is one of the most common vestibular disorders. AIM: To study the recurrence and persistence of BPPV in patients treated with canalith repositioning maneuvers (CRM during the period of one year. STUDY DESIGN: longitudinal contemporary cohort series. MATERIALS AND METHODS: One hundred patients with BPPV were followed up during 12 months after a treatment with CRM. Patients were classified according to disease evolution. Aquatic physiotherapy for vestibular rehabilitation (APVR protocol was applied in cases of persistent BPPV. RESULTS: After CRM, 96% of the patients were free from BPPV's typical nystagmus and dizziness. During the follow up period of 1 year, 26 patients returned with typical BPPV nystagmus and vertigo. Nystagmus and vertigo were persistent in 4% of the patients. Persistent BPPV presented improvement when submitted to APVR. Conclusion: During the period of one year, BPPV was not recurrent in 70% of the patients, recurrent in 26% and persistent in 4%.A vertigem posicional paroxística benigna (VPPB é das vestibulopatias mais comuns. OBJETIVO: Verificar a recorrência e a persistência da VPPB no período de um ano em pacientes que foram tratados com manobras de reposicionamento de estatocônios (MRE. FORMA DE ESTUDO: coorte contemporânea longitudinal. MATERIAL E MÉTODO: Cem pacientes com VPPB foram acompanhados durante 12 meses após o tratamento com MRE. Os pacientes foram classificados de acordo com a evolução da doença no período de um ano. O protocolo de fisioterapia aquática para reabilitação vestibular (FARV foi aplicado nos pacientes com VPPB persistente. RESULTADOS: Após as MRE, 96% dos pacientes aboliram o nistagmo e a vertigem de posicionamento. Destes pacientes, 26 apresentaram recorrência da VPPB, no período de um ano. Em 4% dos pacientes, a VPPB foi persistente. Os pacientes com VPPB persistente apresentaram melhora clínica após a realização da FARV. CONCLUS

  19. Resultados do Balance Rehabilitation Unit na Vertigem Posicional Paroxística Benigna Results from the Balance Rehabilitation Unit in Benign Paroxysmal Positional Vertigo

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    Cristiane Akemi Kasse

    2010-10-01

    Full Text Available A posturografia é um instrumento útil e novo para o estudo da influência das doenças vestibulares no equilíbrio corporal. OBJETIVO: Comparar os resultados da posturografia estática do Balance Rehabilitation Unit (BRU em idosos com Vertigem Postural Paroxística Benigna (VPPB pré e pós a manobra de Epley. MATERIAL E MÉTODO: Estudo prospectivo de 20 pacientes idosos com diagnóstico de VPPB. Os pacientes foram submetidos à posturografia estática do BRU, e o limite de estabilidade (LE e a área de elipse foram medidos. Aplicou-se também o questionário "Dizziness Handicap Inventory" versão brasileira (DHI para verificar a eficácia do tratamento. RESULTADOS: 80% pacientes eram do gênero feminino, com a média etária de 68,15 anos. Após a manobra, o LE aumentou significantemente (p=0,001. A área de elipse nas condições de conflitos sensoriais, visuais e vestibulares da BRU (condições 2,7,8,9 e o escore do DHI diminuíram significantemente (pPosturography is a useful new tool to study the influence of vestibular diseases on balance. AIM: to compare the results from the Balance Rehabilitation Unit (BRU static posturography in elderly patients with Benign Paroxysmal Positional Vertigo (BPPV, before and after Epley's maneuver. MATERIALS AND METHODS: a prospective study of 20 elderly patients with a diagnosis of BPPV. The patients underwent static posturography and the limit of stability (LE and ellipse area were measured. We also applied the Dizziness Handicap Inventory (DHI questionnaire to study treatment effectiveness. RESULTS: 80% were females, with a mean age of 68.15 years. After the maneuver, the LE increased significantly (p=0.001. The elliptical area of somatosensory, visual and vestibular conflicts (2,7,8,9 situations in BRU and the DHI scores decreased significantly (p<0.05 after treatment. CONCLUSION: the study suggests that elderly patients with BPPV may present static postural control impairment and that the maneuver

  20. Manobras de reposicionamento no tratamento da vertigem paroxística posicional benigna Treatment of benign paroxysmal positional vertigo with repositioning manevers

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    Roberto A. Maia

    2001-09-01

    Full Text Available Introdução: Vertigem paroxística posicional benigna (VPPB é uma das mais freqüentes patologias do sistema vestibular. Caracteriza-se clinicamente pela presença de episódios recorrentes de tonturas rotatórias, tipicamente desencadeados por determinados movimentos cefálicos, realizados pelo paciente. A confirmação diagnóstica é obtida exclusivamente pela manobra de Dix-Hallpike. Nessa manobra, observa-se sistematicamente o desencadeamento de nistagmo. Forma de estudo: Prospectivo clínico não randomizado. Material e método: No total, sete pacientes com diagnóstico clínico de VPPB são submetidos a tratamento pela manobra de reposicionamento de Epley. Resultado: Desses sete pacientes avaliados, cinco apresentaram ótima recuperação; dois, com resultado bom; e um, com mau resultado; para este último caso, outras formas de tratamento são apresentadas. Conclusão: O exame otoneurológico, realizado em todos os pacientes, demonstrou ser de interessante valor prognóstico quanto ao resultado do tratamento proposto. A manobra de reposicionamento de Epley demonstrou ser um método de tratamento da VPPB simples, e eficaz na grande maioria dos pacientes aqui relatados.Introduction: Benign Paroxysmal Positional Vertigo (BPPV is among the most common vestibular disorders. It is characterized by recurrent episodes of vertigo induced by changes in head position. The condition is readly diagnosed by performing the Dix-Hallpike maneuver. Nystagmus is always present by this way. Study design: Prospective results clinical not randomized. Material and method: A total of seven patients diagnosed with BPPV received the repositioning maneuver of Epley. Five out of seven patients had excellent recovery, two patients had good results and one had a bad result. For this last one different treatments are discussed. Conclusion: We performed otoneurological examination in all patients; this test seems to be an intersting prognosis method for seeking the

  1. Stress Response and Perinatal Reprogramming: Unraveling (Mal)adaptive Strategies.

    Science.gov (United States)

    Musazzi, Laura; Marrocco, Jordan

    2016-01-01

    Environmental stressors induce coping strategies in the majority of individuals. The stress response, involving the activation of the hypothalamic-pituitary-adrenocortical axis and the consequent release of corticosteroid hormones, is indeed aimed at promoting metabolic, functional, and behavioral adaptations. However, behavioral stress is also associated with fast and long-lasting neurochemical, structural, and behavioral changes, leading to long-term remodeling of glutamate transmission, and increased susceptibility to neuropsychiatric disorders. Of note, early-life events, both in utero and during the early postnatal life, trigger reprogramming of the stress response, which is often associated with loss of stress resilience and ensuing neurobehavioral (mal)adaptations. Indeed, adverse experiences in early life are known to induce long-term stress-related neuropsychiatric disorders in vulnerable individuals. Here, we discuss recent findings about stress remodeling of excitatory neurotransmission and brain morphology in animal models of behavioral stress. These changes are likely driven by epigenetic factors that lie at the core of the stress-response reprogramming in individuals with a history of perinatal stress. We propose that reprogramming mechanisms may underlie the reorganization of excitatory neurotransmission in the short- and long-term response to stressful stimuli. PMID:27057367

  2. Konstrukce osy C malého soustruhu

    OpenAIRE

    Hermanský, Dominik

    2012-01-01

    Predmetom bakalárskej práce je konštrukcia osi C malého sústruhu. Prvá časť obsahuje vymedzenie hlavných pojmov a rešerš v oblasti osi C pre sústruhy a sústružnícke centrá. Ďalšia časť práce sa venuje rozboru rezných síl pri obrábaní s využitím osi C, voľbe vhodného pohonu a brzdového systému. V závere sa pojednáva o tvorbe 3D modelu osi C spolu so sústružníckym vretenom. Súčasťou práce je tiež výkres zostavy.

  3. Sobre a psicogênese do "mal de engasgo"

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    Durval Marcondes

    1947-06-01

    Full Text Available O A. ressalta o aspecto psicológico da etiologia do cardiospasmo ou mal de engasgo, assunto até agora não abordado nos meios científicos brasileiros. Sem pretender afastar outros elementos causais que tenham sido, porventura, verificados e que poderão, talvez, agir concomitantemente, o A. é de opinião que o mal de engasgo é um disturbio funcional condicionado psìquicamente, cujas conseqüências se tornam irreversíveis depois de certo tempo. As conclusões apresentadas baseiam-se no material fornecido por pacientes em tratamento psicanalítico que apresentam fenômenos disfágicos, e por vários casos das clínicas de orientação infantil entre cujos problemas se incluem, além da dificuldade de engulir, a anorexia e a bulimia. Com respeito às atividades emocionais típicas que formam o substrato psicológico do mal de engasgo, o ponto fundamental está em que êste representa um compromisso, expresso ao nível oral, entre tendências passivo-receptivas e ativo-expulsivas. A essa situação psíquica correspondem condições de ambiente, atuais ou pretéritas, que, de modo contraditório, favorecem uma atitude de dependência infantil, ao mesmo tempo que acarretam repetidas frustrações. Trata-se, em geral, de mães dominadoras que, enquanto superprotegem a criança, agem para com ela com demasiado rigor. A superproteção centraliza-se sobretudo no que se refere aos alimentos, que se investem, assim, de grande significado emocional. O A. apresenta o resumo de uma observação clínica que apoia seu ponto de vista. Também a anorexia e a bulimia, em seu substrato psicodinâmico, estão relacionadas com o problema do apego e da emancipação e giram em torno da pessoa da mãe e da função alimentar. A solução do conflito faz-se, porém, num dos casos, pela rejeição do alimento e, noutro, pela avidez. O mal de engasgo constitui o meio têrmo entre os dois extremos. Existem, igualmente, nas neuroses gástricas e em sua conseq

  4. Minilaparoscopic-assisted transvaginal approach in benign liver lesions Abordaje transvaginal asistido por minilaparoscopia en lesiones benignas del hígado

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    R. Castro-Pérez

    2010-06-01

    benignas del hígado tratadas quirúrgicamente mediante el abordaje transvaginal asistido por minilaparoscopia. Pacientes y métodos: mujeres de 44 y 45 años de edad, respectivamente. La paciente 1 presentaba un pequeño tumor de 1,2 cm de Ø, en el lóbulo izquierdo del hígado. En su preoperatorio no se logró precisar su etiología y se decidió extirparlo quirúrgicamente. La paciente 2 presentaba un quiste simple del hígado muy sintomático de 8 cm de Ø situado en el subsegmento VI, se negó a realizarse el tratamiento esclerosante por vía percutánea, por lo que se recomendó el tratamiento quirúrgico. Se les ofreció a ambas realizar la intervención mediante cirugía laparoscópica o el abordaje transvaginal, aceptando este último. El neumoperitoneo se realizó con presión de 15 mmHg. Se colocaron 2 minipuertos en abdomen, uno en región umbilical de 5 mm Ø y el otro de 3 mm Ø en el sitio más próximo a la lesión. Con visión directa se colocó 1 trocar en la pared posterior del fondo del saco vaginal de 11 mm Ø para el paso de un endoscopio rígido. En la paciente 1 se utilizó este mismo orificio para, adyacente al trocar, introducir un disector largo. En la paciente 2 se introdujo un segundo trocar de 5 mm Ø para el paso de instrumentos de trabajo. Ambos especímenes fueron extraídos a través de la vagina en bolsas extractoras. Se registró el tiempo quirúrgico, necesidad de analgésicos y complicaciones postoperatorias. Resultados: los tiempos quirúrgicos fueron de 51 y 73 minutos, respectivamente. La paciente operada del quiste hepático requirió administración de analgésico postoperatorio. El alta hospitalaria fue dada antes de las 24 horas de la intervención. No se han presentado complicaciones postoperatorias relacionadas con el proceder después de un seguimiento mínimo de 6 meses. Conclusiones: con el empleo de instrumentos rígidos, fue posible realizar el tratamiento quirúrgico de dos lesiones benignas del hígado, de poca

  5. Contribución al conocimiento de los malófagos (Phthiraptera, Amblycera, Ischnocera de aves peruanas. Parte 1

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    Luis A. Gomez-Puerta

    2015-12-01

    Full Text Available En el presente trabajo se reporta nueve especies de malófagos colectados de aves peruanas. Dos malófagos Amblycera: Heteromenopon laticapitis y Menacanthus pici, así como siete malófagos Ischnocera: Alcedoffula theresae, Brueelia brunneinucha, Chelopistes meleagridis, Columbicola columbae, Paragoniocotes aratingae, Penenirmus jungens y Saemundssonia (Saemundssonia lari, fueron determinados mediante el diagnóstico morfológico. Se realiza una breve descripción de cada malófago, así como la discusión de sus hospederos y distribución.

  6. Metabolic and functional connectivity changes in mal de debarquement syndrome.

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    Yoon-Hee Cha

    Full Text Available BACKGROUND: Individuals with mal de debarquement syndrome (MdDS experience a chronic illusion of self-motion triggered by prolonged exposure to passive motion, such as from sea or air travel. The experience is one of rocking dizziness similar to when the individual was originally on the motion trigger such as a boat or airplane. MdDS represents a prolonged version of a normal phenomenon familiar to most individuals but which persists for months or years in others. It represents a natural example of the neuroplasticity of motion adaptation. However, the localization of where that motion adaptation occurs is unknown. Our goal was to localize metabolic and functional connectivity changes associated with persistent MdDS. METHODS: Twenty subjects with MdDS lasting a median duration of 17.5 months were compared to 20 normal controls with (18F FDG PET and resting state fMRI. Resting state metabolism and functional connectivity were calculated using age, grey matter volume, and mood and anxiety scores as nuisance covariates. RESULTS: MdDS subjects showed increased metabolism in the left entorhinal cortex and amygdala (z>3.3. Areas of relative hypometabolism included the left superior medial gyrus, left middle frontal gyrus, right amygdala, right insula, and clusters in the left superior, middle, and inferior temporal gyri. MdDS subjects showed increased connectivity between the entorhinal cortex/amygdala cluster and posterior visual and vestibular processing areas including middle temporal gyrus, motion sensitive area MT/V5, superior parietal lobule, and primary visual cortex, while showing decreased connectivity to multiple prefrontal areas. CONCLUSION: These data show an association between resting state metabolic activity and functional connectivity between the entorhinal cortex and amygdala in a human disorder of abnormal motion perception. We propose a model for how these biological substrates can allow a limited period of motion exposure to lead

  7. En busca de una vacuna anti-malárica

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    Edith Suzarte Portal

    2009-01-01

    Full Text Available El desarrollo e implementación de una vacuna contra la malaria representa una necesidad médica urgente para la población que habita las regiones donde ella es endémica. En los últimos años, se han visto progresos significativos en el desarrollo de vacunas, con numerosos candidatos iniciando evaluación en ensayos clínicos. A pesar del optimismo y algunos resultados prometedores, hasta el momento no se cuenta con una vacuna efectiva, en parte, por la falta de conocimiento del tipo de respuesta inmune necesaria para la protección. A esto, se adiciona la dificultad de identificar, seleccionar y producir los antígenos protectores del parásito que posee más de 5 000 genes y un ciclo de vida complejo. Por otra parte, el gran polimorfismo de los antígenos de Plasmodium y los diferentes mecanismos que utiliza para evadir la respuesta inmune hacen necesario aumentar la inmunogenicidad de los antígenos purificados, a través del uso de nuevos adyuvantes o sistemas de liberación. El reto no es meramente científico, se necesita involucrar investigadores competentes, lograr colaboración entre academias, industrias y agencias financiadoras y comprometimiento político. Actualmente, se ensayan diferentes estrategias dirigidas hacia los distintos estadios del parásito. En este manuscrito se destacan algunas de las más avanzadas, otras aún en fase preclínica y algunos fracasos, todas dirigidas contra P. falciparum, así como los principales retos a vencer en la búsqueda de una vacuna anti-malárica efectiva.

  8. Optimización de los protocolos de hiperestimulación ovárica controlada para FIV/ICSI en pacientes diagnosticadas de síndrome de ovarios poliquísticos

    OpenAIRE

    Gil Raga, Fernando

    2010-01-01

    Objetivo principal Comprobar la eficacia y seguridad de la estimulación con FSHr bajo bloqueo gonadotropo hipofisario por administración de una antagonista de GnRH (Ganirelix) iniciando ésta al comienzo del ciclo menstrual, simultáneamente a la administración de FSHr en un grupo de estudio formado por mujeres estériles diagnosticadas de SOP. Material y Métodos Diseño: Estudio longitudinal prospectivo y comparativo, no randomizado, de 3 años de duración. Muestra: 278 pacientes di...

  9. Efecto de un programa de ejercicio físico acuático en la enfermedad de Parkinson: Estudio piloto sobre mujeres diagnosticadas con un grado leve o moderado

    OpenAIRE

    Cancela Carral, José María; C. Ayán; Nascimento, C; Rodríguez, P

    2013-01-01

    Los beneficios del ejercicio físico en personas con enfermedad de Parkinson han sido ampliamente estudiados. Sin embargo, poco se sabe acerca de los efectos del ejercicio acuático en esta población. El propósito de este estudio fue determinar si las mujeres, diagnosticadas de la enfermedad de Parkinson en un grado de leve a moderado, pueden tomar parte y beneficiarse de un programa de ejercicio físico en agua. Doce mujeres con enfermedad de Parkinson (Hoehm y Yahr, rango:1-3), sin demencia y ...

  10. Interaction of PLP with GFP-MAL2 in the human oligodendroglial cell line HOG.

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    Raquel Bello-Morales

    Full Text Available The velocity of the nerve impulse conduction of vertebrates relies on the myelin sheath, an electrically insulating layer that surrounds axons in both the central and peripheral nervous systems, enabling saltatory conduction of the action potential. Oligodendrocytes are the myelin-producing glial cells in the central nervous system. A deeper understanding of the molecular basis of myelination and, specifically, of the transport of myelin proteins, will contribute to the search of the aetiology of many dysmyelinating and demyelinating diseases, including multiple sclerosis. Recent investigations suggest that proteolipid protein (PLP, the major myelin protein, could reach myelin sheath by an indirect transport pathway, that is, a transcytotic route via the plasma membrane of the cell body. If PLP transport relies on a transcytotic process, it is reasonable to consider that this myelin protein could be associated with MAL2, a raft protein essential for transcytosis. In this study, carried out with the human oligodendrocytic cell line HOG, we show that PLP colocalized with green fluorescent protein (GFP-MAL2 after internalization from the plasma membrane. In addition, both immunoprecipitation and immunofluorescence assays, indicated the existence of an interaction between GFP-MAL2 and PLP. Finally, ultrastructural studies demonstrated colocalization of GFP-MAL2 and PLP in vesicles and tubulovesicular structures. Taken together, these results prove for the first time the interaction of PLP and MAL2 in oligodendrocytic cells, supporting the transcytotic model of PLP transport previously suggested.

  11. Tratamento conservador das estenoses benignas do esôfago através de dilatações. Análise de 500 casos

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    ANDREOLLO N.A.

    2001-01-01

    Full Text Available As estenoses benignas do esôfago (EBE são complicações muito freqüentes, resultado de várias etiologias, a saber: refluxo gastro-esofágico, ingestão de agentes corrosivos, pós-cirurgias do esôfago, pós-radioterapia no tórax, pós-escleroterapia endoscópica de varizes do esôfago, ingestão de medicamentos, uso prolongado de cateter nasogástrico, compressão extrínseca e membranas esofágicas congênitas. As dilatações esofágicas são recomendadas no tratamento dessa complicação, empregando dilatadores de vários tipos e diâmetros, facilitando ao doente a ingestão alimentar. OBJETIVOS: Avaliação dos resultados e vantagens do tratamento conservador das EBE através de dilatações esofágicas realizadas ambulatorialmente com auxílio da endoscopia digestiva flexível. MÉTODOS: No período de 1981 a 1999 foram tratados, conservadoramente e seguidos no Gastrocentro -- UNICAMP, 500 doentes com EBE, através de um Programa de Dilatações Esofágicas instituído para cada caso. A maioria era do sexo masculino (59,2% e a faixa etária mais acometida encontra-se entre 31 anos e 60 anos, compreendendo 52,8% dos pacientes em estudo. As estenoses mais prevalentes foram as estenoses pépticas (30,4%, cáusticas (23,6%, de anastomoses (23,2%, por megaesôfago (8,0% e por uso prolongado de cateter nasogástrico (6,4%, perfazendo um total de 91,6% das EBE. Quanto ao número de procedimentos, 94,2% dos casos foram submetidos a no máximo 25 dilatações do esôfago. Em 95,6% deles foram utilizados dilatadores com diâmetro entre 10,5 mm e 16,0 mm. A duração do tratamento foi até 24 meses em 76,2% dos casos. Perfurações esofágicas ocorreram em seis doentes (1,2%, sem mortalidade. RESULTADOS: Foram considerados bons em 76,2%, regulares em 18,2% e maus em 5,6% dos doentes. O sucesso do tratamento variou conforme a etiologia da estenose, ocorrendo bons resultados em 81,0% das estenoses pépticas, em 66,1% das estenoses cáusticas e em

  12. Malá vrtná souprava pro vrtání studní

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    Volec, Martin

    2015-01-01

    Cílem této diplomové práce je návrh konstrukce malé vrtné soupravy pro vrtání studní. Vrtná souprava bude sloužit k vrtání studní do průměru 200 mm technologií rotačním vrtáním s vodním výplachem. V první části práce je provedena rešerše malých vrtných souprav. V druhé části následně vlastní návrh malé vrtné soupravy.

  13. Estado de mal epiléptico en pediatría

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    Jorge Malagón Valdez

    2013-09-01

    Full Text Available El estado de mal epiléptico es una emergencia médica en la cual se presentan crisis epilépticas por 30 minutos o más de actividad continua, o bien dos o más crisis consecutivas sin recuperación completa de la conciencia entre las mismas. Actualmente se considera que una crisis epiléptica convulsiva o no, que dure más de 5 minuto se deberá considerar un estado de mal epiléptico. Se han utilizado diversos fármacos para el tratamiento de esta patología y sus secuelas. Hay un consenso generalizado en que se debe realizar un manejo agresivo para disminuir su morbi-mortalidad, sin olvidarse que la causa del estado de mal es importante para su manejo, control y sus secuelas.

  14. Dermatomiosite recém-diagnosticada em idosos como preditiva de malignidade Newly diagnosed dermatomyositis in the elderly as predictor of malignancy

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    Fernando Henrique Carlos de Souza

    2012-10-01

    Full Text Available OBJETIVO: Os sintomas da dermatomiosite (DM podem ser um indício da existência de um câncer oculto. Melhorar a detecção precoce é essencial, porém não há estudos avaliando em curto prazo os fatores preditivos para a doença. MÉTODO: Estudo retrospectivo, monocêntrico, incluindo pacientes com DM definida (pelo menos quatro dos cinco critérios de Bohan e Peter, 1975, no período entre 1991 e 2011. A presença de malignidade foi limitada a um período de até 12 meses após o diagnóstico da doença. RESULTADOS: Houve 12 casos de neoplasias em 139 pacientes (pele, trato gastrintestinal, próstata, tireoide, mama, pulmão e trato geniturinário. Os pacientes com neoplasia tiveram maior média de idade que os controles (56,8 ± 15,7 vs. 40,3 ± 13,1 anos, respectivamente, P = 0,004; odds ratio 1,09; intervalo de confiança de 95%: 1,04-1,14. Não foram observadas diferenças estatísticas em relação a gênero, etnia, frequência de sintomas constitucionais, envolvimento de órgãos e sistemas e/ou alterações laboratoriais. CONCLUSÃO: Na DM recém-diagnosticada, a idade tardia ao diagnóstico foi um fator preditivo de malignidade.OBJECTIVE: Dermatomyositis (DM symptoms may be a clue to the existence of a hidden cancer. Enhancing early detection is essential, but there are no studies evaluating short-term predictive factors in this disease. METHODS: This is a singlecenter retrospective study, including patients diagnosed with DM meeting at least four of the five Bohan and Peter's criteria (1975, from 1991 to 2011. This study assessed malignancies occurring in up to 12 months after the diagnosis of DM. RESULTS: Neoplasm was found in 12 out of 139 patients (skin, gastrointestinal tract, prostate, thyroid, breast, lungs, and genitourinary tract. Patients with neoplasm had a higher mean age than controls (56.8 ± 15.7 vs. 40.3 ± 13.1 years, respectively, P = 0.004, odds ratio 1.09; 95% confidence interval: 1.04-1.14. No statistical

  15. Agentes etiológicos de onicomicosis diagnosticadas en el laboratorio de micología médica de la Universidad de Costa Rica

    Directory of Open Access Journals (Sweden)

    Ingrid Salas-Campos

    2012-06-01

    Full Text Available Justificación y objetivos: Entre las onicodistrofias, la onicomicosis es la afección más frecuente. Esta infección no solo representa un problema estético para el paciente, sino que puede afectar sus actividades diarias. Para el dermatólogo se hace indispensable realizar el diagnóstico diferencial, por lo que el laboratorio de micología médica es de gran ayuda para este propósito. En cuanto a los agentes etiológicos incriminados, los dermatofitos son los más frecuentes; sin embargo, otros hongos filamentosos no dermatofitos se han aislado, cuya sensibilidad a los antimicóticos es menor. En este trabajo se estudió la frecuencia de las onicomicosis diagnosticadas en el laboratorio de Micología Médica de la UCR durante cuatro años, según edad y sexo de los pacientes, así como agentes etiológicos identificados. Métodos: Se incluyó a todos los pacientes que solicitaron el servicio de acción social que brinda la sección de Micología Médica, Facultad de Microbiología, Universidad de Costa Rica, entre enero del 2007 a diciembre del 2010 y que presentaban alteraciones ungueales sospechosas de onicomicosis. Se registró la edad y sexo de los pacientes y las muestras se procesaron por examen directo y cultivo. Resultados: Se procesaron 431 muestras de uñas, el 85,4% eran de pie y el 14,6% de mano, la edad promedio de los pacientes fue de 49 años, el 64% eran mujeres y el 36% eran hombres. En el 73,4% se diagnosticó onicomicosis, ya sea por examen directo positivo y cultivo positivo, o solo con el examen directo, de las cuales 89,4% eran uñas de pie y 10,6% uñas de manos. De las uñas de los pies se aisló más frecuentemente Trichophyton rubrum y en segundo lugar Fusarium spp. En uñas de manos C. albicans fue el agente etiológico más frecuente. Conclusión: En el diagnóstico de las onicomicosis se debe considerar tanto la clínica como los hallazgos de laboratorio. En la población estudiada se identificaron dermatofitos

  16. Rising Mal-Employment and the Great Recession: The Growing Disconnection between Recent College Graduates and the College Labor Market

    Science.gov (United States)

    Fogg, Neeta P.; Harrington, Paul E.

    2011-01-01

    This article looks at the phenomenon of mal-employment among college graduates in the United States, beginning with an overview of labor-market trends and the effects of the Great Recession on the job-market experiences of young people, including recent college graduates. It then defines "mal-employment" and examines its incidence over time. The…

  17. Estudo do uso de midazolam em crianças com estado de mal epileptico

    OpenAIRE

    Lohr Junior, Alfredo

    2013-01-01

    Resumo: O presente estudo teve o propósito de reavaliar o uso do midazolam em crianças com estado de mal epiléptico refratário. Foram avaliadas 50 crianças com estado de mal epiléptico, internadas na unidade de terapia intensiva do Hospital Infantil Pequeno Príncipe - Curitiba, Paraná, Brasil. O estudo foi caracterizado por dois grupos de pacientes, Grupo A - Midazolam (n=24) prospectivo, e o Grupo B - Thiopental (n=26) histórico. O Grupo Midazolam compôs-se por crianças com o diagnostico cli...

  18. Spatio-temporal analysis of human electroencephalograms: Petit-mal epilepsy

    Science.gov (United States)

    Friedrich, R.; Uhl, C.

    An analysis of multigrid electroencephalograms (EEG) derived from two different persons suffering from petit-mal epilepsy is performed. Using a previously devised method for analyzing spatio-temporal patterns (Uhl, et al., Z. Phys. B 92 (1993) 211-219), we find a suitable mode decomposition of the EEG. Additionally, we are able to extract a three-dimensional dynamical system which describes the dynamics of the patterns as a kind of mode interaction. We show that the spike-wave behavior characteristic for petit-mal epilepsy arising in the dynamical system is related with Sil'nikov-type behavior of the mode dynamics.

  19. Voxel Based Morphometry Alterations in Mal de Debarquement Syndrome.

    Directory of Open Access Journals (Sweden)

    Yoon-Hee Cha

    Full Text Available Mal de debarquement syndrome (MdDS is a disorder of chronic self-motion perception that occurs though entrainment to rhythmic background motion, such as from sea voyage, and involves the perception of low-frequency rocking that can last for months or years. The neural basis of this persistent sensory perception abnormality is not well understood.We investigated grey matter volume differences underlying persistent MdDS by performing voxel-based morphometry on whole brain and pre-specified ROIs in 28 individuals with MdDS and comparing them to 18 age, sex, and handedness matched controls.MdDS participants exhibited greater grey matter volume in the left inferior parietal lobule, right inferior occipital gyrus (area V3v, right temporal pole, bilateral cerebellar hemispheric lobules VIII/IX and left lobule VIIa/VIIb. Grey matter volumes were lower in bilateral inferior frontal, orbitofrontal, pregenual anterior cingulate cortex (pgACC and left superior medial gyri (t = 3.0, p<0.005uncorr. In ROI analyses, there were no volume differences in the middle occipital gyrus (region of V5/MT or parietal operculum 2 (region of the parietoinsular vestibular cortex. Illness duration was positively related to grey matter volume in bilateral inferior frontal gyrus/anterior insula (IFG/AI, right posterior insula, superior parietal lobule, left middle occipital gyrus (V5/MT, bilateral postcentral gyrus, anterior cerebellum, and left cerebellar hemisphere and vermian lobule IX. In contrast, illness duration was negatively related to volume in pgACC, posterior middle cingulate gyrus (MCC, left middle frontal gyrus (dorsolateral prefrontal cortex-DLPFC, and right cerebellar hemispheric lobule VIIIb (t = 3.0, p<0.005uncorr. The most significant differences were decreased volume in the pgACC and increased volume in the left IFG/AI with longer illness duration (qFDRcorr <0.05. Concurrent medication use did not correlate with these findings or have a relationship with

  20. Malária por Plasmodium falciparum: estudos proteômicos

    Directory of Open Access Journals (Sweden)

    Rodrigo Siqueira-Batista

    2012-12-01

    Full Text Available A despeito dos avanços no tratamento e das campanhas de prevenção e de controle da malária nos distintos continentes nos quais a moléstia grassa, a entidade mórbida permanece com significativa relevância no mundo contemporâneo. O Plasmodium falciparum é o grande responsável pela malária grave, caracterizada por distúrbios em diferentes órgãos e sistemas, com possibilidade de evolução ao óbito. Embora incipientes, os estudos proteômicos na malária têm trazido boas perspectivas para melhor compreensão dos aspectos biológicos do Plasmodium, assim como dos mecanismos fisiopatológicos, diagnósticos, terapêuticos e profiláticos da enfermidade. Desse modo, o objetivo do presente artigo é apresentar uma breve revisão das aplicações da análise proteômica na malária por P. falciparum.

  1. Fundamental studies of H2 interaction with MAl3 clusters [M = Li, Sc, Ti, Zr

    International Nuclear Information System (INIS)

    Highlights: • A first-principles calculation on H2 interaction and saturation on stable MAl3 clusters [M = Li, Sc, Ti, Zr] is performed. • Transition metals have negative electron charge density while Al atom has positive in MAl3 from NBO charge analysis. • H2 undergoes dissociative chemisorption on the M atop site resulting in M–H–Al bridge bond. • H2 saturation on M atop site results initially chemisorption and then physisorption with 3-centered Kubas interaction. • External electric field applied on TiAl3H4 leads to more polarization, H2 bond elongation and increased adsorption energy. -- Abstract: Complex metal hydride is a promising hydrogen storage material for automobile applications due to its reversible storage capacity. The presence of transition metal halide is found to improve significantly the kinetics of H2 adsorption and desorption processes. Experimental studies have indicated the formation of distorted MAl3 phase where M = Sc, Ti, Zr. In this study, a first-principles density functional study has been performed to investigate the hydrogen interaction and saturation on stable tetrahedral MAl3 clusters [M = Li, Sc, Ti, and Zr] by employing spin-polarized hybrid and non-local density functionals. On saturation, the first H2 molecule undergoes chemisorption in the transition metals while further loading results in physisorption with the Kubas-type H2 interaction. Activation energy barrier for the H2 dissociation over the cluster is calculated to be ∼0.2 eV for the transition metals. Effect of external electric field on the MAl3H4 cluster with molecular H2 is studied which leads to polarization of physisorbed H2 and the cluster. The results offer an explanation for catalysts role in improving the kinetics of H2 sorption process in complex metal hydrides

  2. Enfermidades diagnosticadas em bezerros na região sul do Rio Grande do Sul Diseases diagnosed in calves in southern Rio Grande do Sul, Brazil

    Directory of Open Access Journals (Sweden)

    Nathalia D. Assis-Brasil

    2013-04-01

    Full Text Available O objetivo deste estudo foi relatar a frequência das enfermidades que ocorrem em bovinos até um ano de idade na área de influência do Laboratório Regional de Diagnóstico (LRD da Faculdade de Veterinária da Universidade Federal de Pelotas (UFPel estabelecendo os principais fatores epidemiológicos associados à ocorrência dessas enfermidades. Foram revisados os protocolos de necropsias realizadas e de materiais de bovinos até um ano de idade, encaminhados ao LRD/UFPel entre 2000 e 2011. Em 35,6% dos casos, os bezerros eram de raças leiteiras e em 33,98% eram animais de raças de corte, 18,3% dos bezerros não tinham raça definida e em 12,1% dos casos não constava a raça no protocolo de necropsia. Os sistemas mais afetados foram o sistema nervoso central (22,7%, o digestivo (18,6% e o respiratório (16,8%. Os diagnósticos foram divididos por faixa etária sendo que 88 bezerros tinham 1-90 dias de idade; 42 casos corresponderam a animais de 4-6 meses; 32 casos corresponderam a bezerros com 7-9 meses e 44 eram bezerros com 10-12 meses de idade. As enfermidades mais frequentemente diagnosticadas nos bezerros de 1-90 dias foram pneumonias, malformações e encefalites/meningoencefalites com 19,3%, 15,9% e 11,3% dos casos, respectivamente. Nos bezerros com 4-6 meses de idade, as pneumonias ocorreram em 16,5% dos casos e o carbúnculo sintomático e as enterites representaram 7,1% dos diagnósticos cada. Nos bezerros de 7-9 meses, as enfermidades mais frequentes foram pneumonias e tétano com 9,3% dos casos e babesiose e parasitoses gastrintestinais com 6,2% cada. Nos bezerros de 10-12 meses a infecção por BoHV-5 representou 13,6% dos casos e as pneumonias, a raiva e as parasitoses foram observadas em 9,% dos casos cada. Com base nos resultados deste trabalho pode-se concluir que as doenças infecciosas relacionadas ao sistema respiratório foram importantes causas de mortalidade em bezerros de todas as faixas etárias na área de influ

  3. Synergistic transcription activation: a dual role for CRP in the activation of an Escherichia coli promoter depending on MalT and CRP

    OpenAIRE

    Richet, Evelyne

    2000-01-01

    Activation of the Escherichia coli malEp promoter relies on the formation of a higher order structure involving cooperative binding of MalT to promoter-proximal and promoter-distal sites as well as CRP binding to three sites located in between. MalT is the primary activator and one function of CRP is to facilitate cooperative binding of MalT to its cognate sites by bending the intervening DNA. It is shown here that CRP also participates directly in malEp activation. This function is carried o...

  4. An essential role for the MAL protein in targeting Lck to the plasma membrane of human T lymphocytes

    OpenAIRE

    Antón, Olga; Batista, Alicia; Millán, Jaime; Andrés-Delgado, Laura; Puertollano, Rosa; Correas, Isabel; Alonso, Miguel A.

    2008-01-01

    The MAL protein is an essential component of the specialized machinery for apical targeting in epithelial cells. The src family kinase Lck plays a pivotal role in T cell signaling. We show that MAL is required in T cells for efficient expression of Lck at the plasma membrane and activation of IL-2 transcription. To investigate the mechanism by which MAL regulates Lck targeting, we analyzed the dynamics of Lck and found that it travels to the plasma membrane in specific transport carriers cont...

  5. Arterite de Takayasu diagnosticada durante o puerpério em mulher com doença hipertensiva gestacional: relato de caso = Takayasu Arteritis diagnosed during puerperium in a woman with pregnancy-induced hypertension: case report

    OpenAIRE

    Hentschke, Marta Ribeiro

    2014-01-01

    Objetivos: Descrever um caso de Arterite de Takayasu diagnosticada durante o puerpério precoce, demonstrando a importância da aferição adequada da pressão arterial para o diagnóstico da doença hipertensiva gestacional. Descrição do caso: Uma mulher de 40 anos, em sua quarta gestação, com idade gestacional de 36 semanas e três dias, foi hospitalizada por gestação de alto risco devido a hipertensão arterial sistêmica crônica. Durante a internação observou-se diferença nos níveis tensionais e...

  6. Trabalhador portuário: perfil de doenças ocupacionais diagnosticadas em serviço de saúde ocupacional Trabajador portuario: perfil de enfermedades ocupacionales diagnosticadas en un servicio de salud ocupacional Dock worker: profile of occupational diseases diagnosed in an occupational health service

    Directory of Open Access Journals (Sweden)

    Marlise Capa Verde de Almeida

    2012-01-01

    Full Text Available OBJETIVO: Identificar as doenças diagnosticadas em trabalhadores portuários avulsos, atendidos em um ambulatório de medicina do trabalho portuário. MÉTODOS: Estudo quantitativo descritivo com análise retrospectiva, que apresentou como fonte de dados as fichas de atendimento médico dos trabalhadores portuários avulsos entre 2000 e 2009. A coleta de dados desenvolveu-se mediante aplicação de um formulário predeterminado e procedeu-se à análise quantitativa descritiva em 953 fichas médicas dos trabalhadores. RESULTADOS: totalizou-se 953 fichas médicas (94,7%, das quais 90,47% pertenciam a trabalhadores do sexo masculino, 52% na faixa etária acima de 50 anos e 51,7% com mais de 19 anos de atuação. Identificaram-se 527 diagnósticos, sendo os principais relacionados ao trabalho: hipertensão (8,3%, lombalgia (6,2%, outras doenças pulmonares (1,7% e episódios depressivos (1,2%. CONCLUSÃO: constatou-se o acometimento do trabalhador por patologias ocupacionais de ordem mental, circulatória, respiratória e osteomuscular, evidenciando morbidades que o afetam e interferem em sua qualidade de vida e na produtividade das atividades laborais.OBJETIVO: Identificar las enfermedades diagnosticadas en trabajadores portuarios independientes, atendidos en un consultorio externo de medicina del trabajo portuario. MÉTODOS: Estudio cuantitativo descriptivo con análisis retrospectivo, que presentó como fuente de datos las fichas de atención médica de los trabajadores portuarios independientes entre 2000 y 2009. La recolección de los datos se desarrolló mediante la aplicación de un formulario estructurado y se procedió a realizar el análisis cuantitativo descritivo de 953 fichas médicas de los trabajadores. RESULTADOS: De un total de 953 fichas médicas (94,7%, el 90,47% pertenecían a trabajadores del sexo masculino, el 52% se encontraba en el grupo etáreo arriba de los 50 años y el 51,7% con más de 19 años de actuación. Se

  7. [Eugen Helimski, Urlike Kahrs. Nordselkupisches Wörterbuch von F. G. Mal'cev (1903)] / Ago Künnap

    Index Scriptorium Estoniae

    Künnap, Ago, 1941-

    2003-01-01

    Raamatust: Helimski, Eugen, Kahrs, Urlike. Nordselkupisches Wörterbuch von F. G. Mal'cev (1903). Hamburg, 2001. (Hamburger Sibirische und Finnisch-Ugrische Materialen / Habent Sua Fata Manuscripts; 1)

  8. Römischův panteon na Malé Skále a jeho kontext. [Doslov

    Czech Academy of Sciences Publication Activity Database

    Petrasová, Taťána

    Praha : Argo, 2015, s. 275-282 ISBN 978-80-257-0608-4 Institutional support: RVO:68378033 Keywords : Malá Skála * pantheon * Franz Zacharias Römisch Subject RIV: AL - Art, Architecture, Cultural Heritage

  9. Relationship between diet and benign prostatic hyperplasia Relación entre la dieta y el desarrollo de Hiperplasia Prostática Benigna: ¿Qué nos dice la evidencia científica actual?

    Directory of Open Access Journals (Sweden)

    Jon Kepa Balparda Arias

    2010-02-01

    Full Text Available

    Benign prostatic hyperplasia is very common in the general population, both from the histological and the clinical points of view. The role of different factors in its development has been defined by means of epidemiological studies. One such factor is the composition of the diet, as the regular consumption of certain foods may either protect against benign prostatic hyperplasia or increase the risk of its development. Among foods which may play a protective role are lycopene, phytoestrogens and vegetables. On the other hand, the risk of developing the disease may be increased by a diet rich in fat and calories. In this article the main clinical trials concerning this relationship are reviewed, as a way of informing physicians on the dietetic patterns that may influence the frequency or the symptoms of this disease.

    La hiperplasia prostática benigna es muy común en la población general, tanto desde el punto de vista histológico como del clínico. El papel en ella de diversos factores se ha definido por medio de estudios epidemiológicos. Entre ellos está el consumo regular de algunos alimentos que podría actuar como un factor protector o de riesgo para el posterior desarrollo de la enfermedad. Entre los compuestos demostrados como benéficos para la salud prostática están los licopenos, los fitoestrógenos y las verduras. Por otro lado, entre los que podrían aumentar el riesgo de sufrir la hiperplasia prostática benigna se incluyen las dietas hipercal

  10. Corporate social responsibility jako součást strategie malé firmy

    OpenAIRE

    Linhartová, Zuzana

    2008-01-01

    Cílem této práce bylo zmapování situace konceptu CSR se zaměřením na malý podnik. Stěžejní přínos pak spočívá především v aplikaci konkrétního návrhu CSR a jeho implementace do celkové podnikatelské strategie reprezentanta malých a středních podniků ? výzkumné agentury Market Vision, s.r.o.Jednotlivé kroky implementace CSR jsou navrženy z hlediska COSORE ? Balance ? Scorecard modelu, ve kterém se na tuto problematiku nahlíží ze čtyř základní perspektiv ? zainteresovaných stran, finanční, proc...

  11. SmartMal: a service-oriented behavioral malware detection framework for mobile devices.

    Science.gov (United States)

    Wang, Chao; Wu, Zhizhong; Li, Xi; Zhou, Xuehai; Wang, Aili; Hung, Patrick C K

    2014-01-01

    This paper presents SmartMal--a novel service-oriented behavioral malware detection framework for vehicular and mobile devices. The highlight of SmartMal is to introduce service-oriented architecture (SOA) concepts and behavior analysis into the malware detection paradigms. The proposed framework relies on client-server architecture, the client continuously extracts various features and transfers them to the server, and the server's main task is to detect anomalies using state-of-art detection algorithms. Multiple distributed servers simultaneously analyze the feature vector using various detectors and information fusion is used to concatenate the results of detectors. We also propose a cycle-based statistical approach for mobile device anomaly detection. We accomplish this by analyzing the users' regular usage patterns. Empirical results suggest that the proposed framework and novel anomaly detection algorithm are highly effective in detecting malware on Android devices. PMID:25165729

  12. Structure of the conserved hypothetical protein MAL13P1.257 from Plasmodium falciparum

    International Nuclear Information System (INIS)

    The crystal structure of a conserved hypothetical protein, MAL13P1.257 from P. falciparum, has been determined at 2.17 Å resolution. The structure represents a new protein fold and is the first structural representative for Pfam sequence family PF05907. The structure of a conserved hypothetical protein, PlasmoDB sequence MAL13P1.257 from Plasmodium falciparum, Pfam sequence family PF05907, has been determined as part of the structural genomics effort of the Structural Genomics of Pathogenic Protozoa consortium. The structure was determined by multiple-wavelength anomalous dispersion at 2.17 Å resolution. The structure is almost entirely β-sheet; it consists of 15 β-strands and one short 310-helix and represents a new protein fold. The packing of the two monomers in the asymmetric unit indicates that the biological unit may be a dimer.

  13. MAL2 and tumor protein D52 (TPD52 are frequently overexpressed in ovarian carcinoma, but differentially associated with histological subtype and patient outcome

    Directory of Open Access Journals (Sweden)

    Fanayan Susan

    2010-09-01

    Full Text Available Abstract Background The four-transmembrane MAL2 protein is frequently overexpressed in breast carcinoma, and MAL2 overexpression is associated with gain of the corresponding locus at chromosome 8q24.12. Independent expression microarray studies predict MAL2 overexpression in ovarian carcinoma, but these had remained unconfirmed. MAL2 binds tumor protein D52 (TPD52, which is frequently overexpressed in ovarian carcinoma, but the clinical significance of MAL2 and TPD52 overexpression was unknown. Methods Immunohistochemical analyses of MAL2 and TPD52 expression were performed using tissue microarray sections including benign, borderline and malignant epithelial ovarian tumours. Inmmunohistochemical staining intensity and distribution was assessed both visually and digitally. Results MAL2 and TPD52 were significantly overexpressed in high-grade serous carcinomas compared with serous borderline tumours. MAL2 expression was highest in serous carcinomas relative to other histological subtypes, whereas TPD52 expression was highest in clear cell carcinomas. MAL2 expression was not related to patient survival, however high-level TPD52 staining was significantly associated with improved overall survival in patients with stage III serous ovarian carcinoma (log-rank test, p Conclusions MAL2 is frequently overexpressed in ovarian carcinoma, and TPD52 overexpression is a favourable independent prognostic marker of potential value in the management of ovarian carcinoma patients.

  14. Adverse Impact of the Historic Mining Activities on the Enviroment in Malé Karpaty

    OpenAIRE

    Daniel Jozef; Malár Eduard; Slovik Jozef

    2002-01-01

    During 1999 2001 the Ministry of the Environment of the Slovak Republic has financed the geological work Evaluation of the Adverse Impact of Mining Activities on the Environment in the Region of Malé Karpaty. Results and recommendations of the work in this contribution are discussed.Mineral resources, such as pyrit pyrhotite deposits, hydrothermal metal ore deposits (Au Ag, pyrit Cu, Pb Ag, Zn, Sb), hydrothermal deposits of barytes and manganesian ore deposits are situated in mining dist...

  15. The (Mal)Practice of Dowry in Contemporary India. A Challenge to Marriage and Family Ministry

    OpenAIRE

    Jainus Xavier, Nixen Raj; Knieps-Port le Roi, Thomas

    2012-01-01

    The author explores the (mal)practice of dowry in contemporary India and the challenge it presents to marriage and family ministry. He explains how originally harmless and well-intended dowry customs changed under the influence of historical circumstances that turned them into a business-like family strategy aimed at rising families’ social status, wealth and power. This evolution had dramatic consequences for Indian marriage and family life and especially for women. Dowry-related violence an...

  16. Disease Surveillance Methods Used in the 8-Site MAL-ED Cohort Study

    OpenAIRE

    Richard, Stephanie A.; Barrett, Leah J; Richard L. Guerrant; Checkley, William; Miller, Mark A.

    2014-01-01

    Describing the early life associations between infectious disease episodes and growth, cognitive development, and vaccine response in the first 2 years of life is one of the primary goals of the Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) cohort study. To collect high-resolution data during a critical early period of development, field staff visit each study participant at their house twice weekl...

  17. SmartMal: A Service-Oriented Behavioral Malware Detection Framework for Mobile Devices

    OpenAIRE

    Chao Wang; Zhizhong Wu; Xi Li; Xuehai Zhou; Aili Wang; Hung, Patrick C. K.

    2014-01-01

    This paper presents SmartMal—a novel service-oriented behavioral malware detection framework for vehicular and mobile devices. The highlight of SmartMal is to introduce service-oriented architecture (SOA) concepts and behavior analysis into the malware detection paradigms. The proposed framework relies on client-server architecture, the client continuously extracts various features and transfers them to the server, and the server's main task is to detect anomalies using state-of-art detection...

  18. Mal de Debarquement Syndrome: A Rare Entity—A Case Report and Review of the Literature

    OpenAIRE

    Veronica Nwagwu; Rakesh Patel; Jerome Okudo

    2015-01-01

    Mal de Debarquement Syndrome (MDS) is a rare, understudied, underdiagnosed, and self-limiting condition. Etiology and incidence are unknown. It is characterized by abnormal sensation of motion/balance reported after travel by air, land, and sea; being reexposed to motion/activity relieves it. Symptoms may last from minutes to years. Workup though required reveals no findings; it is a diagnosis of exclusion. While no efficacious treatment exists, amitriptyline and benzodiazepines as well as su...

  19. Integrating Electrodermal Biofeedback into the Treatment of Grand-Mal Seizures

    Directory of Open Access Journals (Sweden)

    Tullio Michele Scrimali

    2015-05-01

    Full Text Available Electrodermal activity and electrodermal biofeedback, when integrated into pharmacologic treatments, are promising methods for grand mal seizures. They can be used to monitor the patient arousal and help the patient learn some new strategies for better coping with stress and anxiety. Our proposed method can possibly reduce the number of crises for patients who are dependent on pharmacologic therapy and can also improve their quality of life. This article describes the scientific background of electrodermal monitoring and electrodermal biofeedback for patients affected by grand mal seizures. In this study, we have reported a clinical case study. A patient is treated for two years with electrodermal biofeedback to augment pharmacologic treatments. The trial has been designed according to a n=1 case study research. Our results showed that our methods can achieve a significant reduction in grand mal seizures and sympathetic arousal. The patient in consideration was also relaxed and exhibited a greater competency in coping with stress. In addition, the patient’s sense of mastery and self-efficacy was enhanced.

  20. CFD modelling of flow mal-distribution in an industrial ammonia oxidation reactor: A case study

    International Nuclear Information System (INIS)

    Ammonia oxidation reactor is widely used in nitric acid plant to cause the catalytic reaction between air and ammonia to produce nitrous gases. In this work, the flow distribution inside the ammonia oxidation reactor at Shiraz Petrochemical Complex (SPC) has been simulated using Computational Fluid Dynamics (CFD) code. The CFD results showed that the flow is non-uniformly distributed inside the reactor due to improper header design of the reactor. Measuring of the temperature distribution around the skin of the reactor has been carried out using thermograph. The thermograph experiment showed a considerable temperature difference between the left and right side of the reactor. It was found that the mal-distribution of the gas flow inside the reactor can directly affect the performance of the reactor. - Highlights: •A failure has been observed in an industrial ammonia oxidation reactor. •CFD code helps to simulate the flow inside the reactor. •The flow becomes non-uniformly distributed due to the reactor header mal-design. •The flow mal-distribution results in some drawbacks

  1. Antimyeloma Effects of the Heat Shock Protein 70 Molecular Chaperone Inhibitor MAL3-101

    Directory of Open Access Journals (Sweden)

    Marc J. Braunstein

    2011-01-01

    Full Text Available Multiple myeloma (MM is the second most common hematologic malignancy and remains incurable, primarily due to the treatment-refractory/resistant nature of the disease. A rational approach to this compelling challenge is to develop new drugs that act synergistically with existing effective agents. This approach will reduce drug concentrations, avoid treatment resistance, and also improve treatment effectiveness by targeting new and nonredundant pathways in MM. Toward this goal, we examined the antimyeloma effects of MAL3-101, a member of a new class of non-ATP-site inhibitors of the heat shock protein (Hsp 70 molecular chaperone. We discovered that MAL3-101 exhibited antimyeloma effects on MM cell lines in vitro and in vivo in a xenograft plasmacytoma model, as well as on primary tumor cells and bone marrow endothelial cells from myeloma patients. In combination with a proteasome inhibitor, MAL3-101 significantly potentiated the in vitro and in vivo antimyeloma effects. These data support a preclinical rationale for small molecule inhibition of Hsp70 function, either alone or in combination with other agents, as an effective therapeutic strategy for MM.

  2. Pequeno mal epiléptico em crianças. Considerações sobre o efeito do tridione em 4 casos

    Directory of Open Access Journals (Sweden)

    Antonio B. Lefévre

    1949-03-01

    Full Text Available The author administered Tridione in four patients under five years of age with "petit mal" seizures. In all cases there was complete disappearance of the seizures eventhough small doses were used. In one case the EEG, taken after the Tridione treatment, did not show the previous "petit mal" pattern. In no case there were signs of intolerance. In conclusion the author thoroughly agree that Tridione is the drug of choice in "petit mal" seizures.

  3. Performances of air source heat pump system for a kind of mal-defrost phenomenon appearing in moderate climate conditions

    International Nuclear Information System (INIS)

    Highlights: ► Mal-defrost performances of ASHP in moderate environment are investigated. ► The system COP decreases to 2.3 under environment temperature of 7.9 °C. ► The decrease of the ASHP heating capacity can get to 43.4%. ► The origins of this special mal-defrost phenomenon were discussed. ► Suggestions were proposed to modify the current defrosting control strategies. - Abstract: To quantify the performance drop of the air source heat pump (ASHP) system under a special kind of mal-defrost phenomenon appearing in moderate climate conditions, a field test was conducted for 8 days at the initial stage of a heating season in Beijing, China. The mal-defrost was found with the more than 60% frosted area of the outdoor heat exchanger after the system running 5 days. During this frosting period, the system COP was significantly degraded, only 2.3 under an environment temperature of 7.9 °C. Comparing the test data before and after frosting, it was found that the mal-defrost decreased the COP up to 40.4% and the heating capacity to 43.4%. Such low energy efficiency continued quite a long time until the defrost control was started up manually by the authors. After defrosting, the COP reclaimed to the normal level of 5.0. The origins of this special mal-defrost phenomenon were discussed. And some suggestions were proposed to modify the current defrosting control strategy, which were helpful to avoid the mal-defrost problem in the current ASHP system and therefore improve the system performances

  4. Tagosodes orizicolus: A new potential vector of Mal de Río Cuarto virus

    OpenAIRE

    2008-01-01

    Una enfermedad que afecta severamente el rendimiento del cultivo de maíz es conocida como mal de Río Cuarto. El vector más importante es Delphacodes kuscheli. Este trabajo tuvo como objetivo determinar la capacidad vectora de una nueva especie, Tagosodes orizicolus, en campo y bajo condiciones experimentales. Los ensayos de transmisión se realizaron con ambas especies simultáneamente. Para la adquisición, latencia e infección se utilizaron los tiempos considerados óptimos para D. kuscheli. La...

  5. Percepce malých moravských měst jejich obyvateli

    Czech Academy of Sciences Publication Activity Database

    Frantál, Bohumil; Pokluda, František

    Brno: Ústav geoniky AV ČR, pobočka Brno, 2004 - (Vaishar, A.; Frantál, B.), s. 1-7 [Národní seminář ke geografii malých měst. Brno (CZ), 24.06.2004-26.06.2004] R&D Projects: GA AV ČR IAA3086301 Institutional research plan: CEZ:AV0Z3086906 Keywords : perception * image * urban liveability * residential satisfaction * quality of life Subject RIV: DE - Earth Magnetism, Geodesy, Geography

  6. SLURP1 is a late marker of epidermal differentiation and is absent in Mal de Meleda

    DEFF Research Database (Denmark)

    Favre, Bertrand; Plantard, Laure; Aeschbach, Lorène; Brakch, Noureddine; Christen-Zaech, Stephanie; de Viragh, Pierre A; Sergeant, Ann; Huber, Marcel; Hohl, Daniel

    2007-01-01

    SLURP1 is a secreted member of the LY6/PLAUR protein family. Mutations in the SLURP1 gene are the cause of Mal de Meleda (MDM), a rare autosomal recessive genetic disease, characterized by inflammatory palmoplantar keratoderma. In this study, we have analyzed the expression of SLURP1 in normal an...... mutation W15R located in the signal peptide. Thus, most MDM mutations in SLURP1 affect either the expression, integrity, or stability of the protein, suggesting that a simple immunologic test could be used as a rapid screening procedure....

  7. Effect of refrigerant mal-distribution in fin-and-tube evaporators on system performance

    DEFF Research Database (Denmark)

    Kærn, Martin Ryhl; Elmegaard, Brian; Larsen, Lars Finn Sloth

    2009-01-01

    Refrigerant mal-distribution in fin-and-tube evaporators for residential air-conditioning (RAC) is investigated numerically in this paper. A model of the system is developed in the object-oriented modeling language Modelica. Themodels of the compressor and expansion valve are static, whereas...... the condenser is a dynamic moving boundary model. The evaporator model is a dynamic distributed one-dimensional homogeneous equilibrium model, in order to capture the distribution phenomena. Fin-and-tube heat exchangers usually have a complex circuitry, however the evaporator will be simplified to be two...

  8. Do mal ao banal: Uma interpretação do discurso social sobre a SIDA

    OpenAIRE

    Lopes, Maria de Fátima Triguinho

    2001-01-01

    Dissertação de mestrado em Psicopatologia e Psicologia Clínica Será que um mal passou a banal, foi a questão de partida para analisarmos diferentes perspectivas sociais sobre a SIDA, doença que coloca um amplo espectro de inquietações, mas com a qual convivemos já quase pacificamente. Esta dissertação procura encontrar nos discursos sociais sobre a doença, em particular nos discursos religioso, científico e psicológico, a evolução do pensamento social, bem como as invariantes que lhe sã...

  9. El mal de ojo como enfermedad: elitelore y folklore en Iberoamérica

    Directory of Open Access Journals (Sweden)

    Idoyaga Molina, Anatilde

    2014-06-01

    Full Text Available The article claims that general theories about the evil eye lore have not considered its occurrences as an illness, the gazer´s and victim´s characterization in terms of ancient Western medicine, as well as the naturalization of moral contents. The authors sustain that the evil eye in Iberoamerica is a folk illness, whose etiological theories exceed the human domain, including animals as aggressors. The evil eye lore as an illness incorporates natural etiologies, and social theories linked to envy, anger, fondness and love. To overcome these supposed contradictions, the authors call the attention to consider the historical processes of construction of the evil eye lore, taking into account the process of filtering down from the elite and medical official knowledge to popular sectors, underlining the relevance of being aware of the evil eye was defined as a real disease, during the Middle and Modern Ages.Revisamos los marcos conceptuales del mal de ojo, destacando que tales teorías dejan de lado sus manifestaciones como enfermedad, la caracterización de los ojeadores y de las víctimas en términos de la antigua medicina científica. Los autores sostienen que el mal de ojo en Iberoamérica es el nombre de una enfermedad, cuyos contenidos y teorías etiológicas exceden el dominio humano, incluyendo ojeadores animales. Como enfermedad incorpora causas naturales, además de causas sociales ligadas con la envidia, los celos, el encono y el cariño. Para entender estas manifestaciones, aparentemente contradictorias, se llama la atención sobre la relevancia de considerar los procesos históricos de construcción de la creencia en el mal de ojo, la relación entre los saberes de elite y los procesos de popularización de esos saberes, subrayando la relevancia del reconocimiento del mal de ojo como enfermedad por la antigua medicina académica en tales procesos.

  10. ACCUMULATION OF POLYHYDROXYALKANOIC ACIDS BY AZOTOBACTER CHROOCOCCUM MAL-201 FROM ORGANIC WASTE

    OpenAIRE

    Soma Pal Saha; A. Patra; P. B. Ghosh; A.K. Paul

    2013-01-01

    Azotobacter chroococcum MAL-201 (MTCC 3853), a free-living nitrogen-fixing bacterium accumulated intracellular poly(3-hydroxybutyric acid) [P(3HB)] accounting 69% of cell dry weight (CDW) when grown in nitrogrn-free Stockdale medium containing 2% (w/v) glucose. It also produced copolymer of poly(3-hydroxybutyrate co-3-hydroxyvalerate) [P(3HB-co-3HV)] using glucose as primary carbon source and valerate cas cosubstrate. To make the polymer production cost effective four types of waste material ...

  11. Role of Helicobacter pylori in stomach cancer after partial gastrectomy for benign ulcer disease Papel del Helicobacter pylori en el cáncer gástrico tras gastrectomía parcial por úlcera benigna

    Directory of Open Access Journals (Sweden)

    A. Seoane

    2005-11-01

    Full Text Available Objective: to determine the prevalence of Helicobacter pylori infection in patients having undergone gastrectomy for non-neoplastic disease who later developed gastric stump cancer. Material and methods: retrospective study of all patients with partial gastrectomy for non-malignant peptic disease who were submitted to an endoscopic exploration between 1995 and 2001. A comparison was made of major clinical and histological characteristics, and the presence of Helicobacter pylori among patients with and without gastric cancer in the stomach remnant. Results: a total of 73 patients were studied in this period. Fifteen patients (20.5% had remnant-stump gastric cancer. All but one were adenocarcinomas (71% intestinal and 29% diffuse, respectively. The average time between diagnosis of gastric cancer and previous gastrectomy was 32 (14-48 years. There was a higher detection rate of Helicobacter pylori in patients with cancer in the gastric remnant (100 vs. 81.5%, respectively, p Objetivo: determinar la prevalencia de la infección por Helicobacter pylori en pacientes gastrectomizados por enfermedad no neoplásica, y que han desarrollado posteriormente cáncer gástrico. Material y métodos: estudio retrospectivo con reclutamiento de todos los pacientes con gastrectomía parcial por enfermedad péptica benigna que han sido sometidos a una exploración endoscópica entre 1995-2001. Se ha realizado una comparación de las principales características clínicas e histológicas y de la presencia de Helicobacter pylori en los pacientes con y sin cáncer del remanente gástrico. Resultados: se han estudiado un total de 73 pacientes en este periodo. Se han encontrado 15 pacientes (20,5% con cáncer en el remanente gástrico, 14 adenocarcinomas (71% tipo intestinal y 29% tipo difuso y un linfoma. El tiempo transcurrido entre el diagnóstico de cáncer gástrico y la gastrectomía previa ha sido de 32 (14-48 años. Se ha detectado un alto porcentaje de infecci

  12. Desempenho escolar em crianças com epilepsia benigna da infância com pontas centrotemporais School performance in children with benign childhood epilepsy with centrotemporal spikes

    Directory of Open Access Journals (Sweden)

    Lineu Corrêa Fonseca

    2004-06-01

    Full Text Available Aspectos psicossociais em crianças com epilepsia benigna da infância com pontas centrotemporais (EBICT são objeto de controvérsias. O objetivo desta pesquisa foi estudar o desempenho escolar em crianças com EBICT. Vinte crianças foram submetidas ao Teste de Desempenho Escolar (TDE e comparadas a crianças sadias pareadas por idade e escolaridade. Foram estudadas as relações entre o TDE e a lateralidade do foco e o número de descargas ao eletrencefalograma. As crianças com EBICT tiveram, de modo significativo, mais freqüentemente do que as sadias, desempenho inferior no subteste de leitura e no escore total. As crianças com desempenho inferior em leitura apresentaram maior número de descargas do que aquelas com desempenho médio e superior. Não houve diferenças no TDE segundo a lateralidade do foco. O número de descargas, ao interferir com a função cerebral, pode ser um fator a explicar o desempenho mais baixo na leitura.Neuropsychological implications of benign childhood epilepsy with centrotemporal spikes-rolandic spikes (BECTS have not been adequately investigated. The aim of this study was to compare the results in a school performance test of patients with BECTS and normal age-matched controls. A total of 20 children with BECTS and 20 normal controls were submitted to anamnesis, clinical evaluation, Raven test, school performance test (SPT, digital electroencephalogram and quantitative electroencephalogram analysis. Comparing with normal controls, children with BECTS showed significantly lower SPT results, especially in reading test. There was an association between the higher number of rolandic spikes and inferior performance in SPT reading test. These findings suggest that discharges may be a factor in the genesis of lower performance in reading test in children with BECTS.

  13. Malária em grávidas de uma maternidade pública de Rio Branco (Acre, Brasil)

    OpenAIRE

    Jarude Regina; Trindade Ronald; Tavares-Neto José

    2003-01-01

    OBJETIVO: descrever a freqüência dos achados clínico-laboratoriais em grávidas portadoras de malária. MÉTODOS: foi realizado estudo descritivo, série de casos, de 445 grávidas da Maternidade e Clínica de Mulheres Bárbara Heliodora (Rio Branco, Acre), do período de janeiro de 1996 a dezembro de 2001, com diagnóstico parasitológico de malária. Foram revistos os prontuários do período e selecionados os casos portadores de malária. RESULTADOS: no total de pacientes (n=33.420) internadas no períod...

  14. Exposure to Glycolytic Carbon Sources Reveals a Novel Layer of Regulation for the MalT Regulon

    Directory of Open Access Journals (Sweden)

    Sylvia A. Reimann

    2011-01-01

    Full Text Available Bacteria adapt to changing environments by means of tightly coordinated regulatory circuits. The use of synthetic lethality, a genetic phenomenon in which the combination of two nonlethal mutations causes cell death, facilitates identification and study of such circuitry. In this study, we show that the E. coli ompR malTcon double mutant exhibits a synthetic lethal phenotype that is environmentally conditional. MalTcon, the constitutively active form of the maltose system regulator MalT, causes elevated expression of the outer membrane porin LamB, which leads to death in the absence of the osmoregulator OmpR. However, the presence and metabolism of glycolytic carbon sources, such as sorbitol, promotes viability and unveils a novel layer of regulation within the complex circuitry that controls maltose transport and metabolism.

  15. Development of hypo-allergenic apples: silencing of the major allergen Mal d 1 gene in "Elstar" apple and the effect of grafting

    DEFF Research Database (Denmark)

    Krath, Britta; Eriksen, Folmer Damsted; Pedersen, Bjarne H.;

    2009-01-01

    Mal d 1 mRNA were produced by RNA interference (RNAi) technology. Ten genetically modified (GM) apple lines were selected. In vitro plantlets were first transferred to a greenhouse, then grafted onto wild-type M.9 rootstock to promote the development of fruit-producing trees. Levels of Mal d 7 gene...

  16. Du mal a dire: maladie et défaillance du moi dans quatre romans d’Amélie Nothomb

    OpenAIRE

    Álvares, Cristina

    2015-01-01

    Cet article inscrit le rapport entre maladie et moi mis à mal dans la problématique nothombienne de la dérégulation de la relation intersubjective, en suivant le mot de l’auteur pour qui l’étymologie de maladie est mal à dire.

  17. Recombinant Mal d 1 facilitates sublingual challenge tests of birch pollen-allergic patients with apple allergy

    OpenAIRE

    Kinaciyan, T; Nagl, B.; Faustmann, S.; Kopp, S.; Wolkersdorfer, M.; Bohle, B

    2015-01-01

    It is still unclear whether allergen-specific immunotherapy (AIT) with birch pollen improves birch pollen-related food allergy. One reason for this may be the lack of standardized tests to assess clinical reactions to birch pollen-related foods, for example apple. We tested the applicability of recombinant (r) Mal d 1, the Bet v 1-homolog in apple, for oral challenge tests. Increasing concentrations of rMal d 1 in 0.9% NaCl were sublingually administered to 72 birch pollen-allergic patients w...

  18. MalT, the regulatory protein of the Escherichia coli maltose system, is an ATP-dependent transcriptional activator.

    OpenAIRE

    Richet, E; Raibaud, O

    1989-01-01

    We show that MalT, the transcriptional activator of the Escherichia coli maltose regulon, specifically binds ATP and dATP with a high affinity (Kd = 0.4 microM) and exhibits a weak ATPase activity. Using an abortive initiation assay, we further show that activation of open complex formation by MalT depends on the presence of ATP in addition to that of maltotriose, the inducer of the maltose system. Similar experiments in which ATP was replaced by ADP or AMP-PNP, a non-hydrolysable analogue of...

  19. Návrh malé vodní nádrže

    OpenAIRE

    Galuška, Martin

    2013-01-01

    Práce se zabývá posouzením možnosti návrhu malé vodní nádrže na vytipovaném území obce Bezměrov. Součástí práce je pojednání o typech a funkcích malých vodních nádrží a jejich vodohospodářském řešení. Je vyhodnocen geologický průzkum lokality, který mapuje skladbu vrstev zeminy a dostupných materiálů pro výstavbu hráze. Pro konkrétní uvažované profily hráze je vypracována vodní bilance, která hodnotí specifický odtok z povodí, výpar a průsak vody tělesem zjednodušeně navržené hráze. Vzniká ta...

  20. Olhar de dirigentes sindicais sobre qualidade de vida no trabalho e mal-estar no trabalho

    Directory of Open Access Journals (Sweden)

    Remigio Todeschini

    2013-06-01

    Full Text Available O objeto do artigo consistiu em conhecer as percepções de dirigentes sindicais metalúrgicos e químicos sobre o tema Qualidade de Vida no Trabalho (QVT e as fontes de mal-estar no trabalho nessas categorias profissionais. A natureza metodológica aplicada foi quantitativa e qualitativa com utilização do software Alceste. Participaram da pesquisa 81 dirigentes sindicais brasileiros (56 dirigentes químicos e 25 metalúrgicos, 85% do gênero masculino e 15% do gênero feminino oriundos das regiões sudeste, sul e nordeste do país, com aplicação do questionário via e-mail. Os resultados encontrados forneceram bases empíricas para a formulação de recomendações em Ergonomia da Atividade visando prevenir as fontes de mal-estar no trabalho. Foram reforçadas as bases teóricas da Abordagem de Ergonomia da Atividade Aplicada à Qualidade de Vida no Trabalho (EAA_QVT e o desenho de subsídios para a formulação de políticas públicas neste campo.

  1. A review of the prevalence and factors responsible for mal-nutrition in Pakistan

    Directory of Open Access Journals (Sweden)

    Hafsa Hina

    2015-01-01

    Full Text Available Problems occupying special attention identified by the World Health Organization also include Childhood malnutrition (Beagle hole et al., 1993. Development goals are also program by the United Nations to halve the problem of under nutrition (Alderman et al., 2005. Despite of the involvement of international organizations still under nutrition has a main contribution to the high mortality rate of the children in the most part of the world (Caulfield et al., 2004. Poverty plays a main part in the high prevalence of childhood under nutrition. The child is said to be under-weight when its weight is lower than the weight of the reference rage for that age. The weight for height deficiency is known as wasting, while height for age deficiency as stunting. Wasting may be due to acute food shortage while prolonged food deprivation can cause stunting (Cosminsky et al., 1993; de Onis et al., 2000; Fernandez et al., 2002; and Zere & McIntyre, 2003. The factors responsible for the predisposition of children to mal nutrition vary and ranges from political instability to the economical status of the area (de Onis et al., 2000. Therefore protocols developed for the preventive measures of mal-nutrition should be multifaceted. 

  2. AVALIAÇÃO DO NÍVEL SÉRICO DE ANTÍGENO PROSTÁTICO ESPECÍFICO (PSA) E RELAÇÃO COM HIPERPLASIA BENIGNA PROSTÁTICA E CÂNCER DE PRÓSTATA EM PACIENTES ATENDIDOS EM UM LABORATÓRIO DE ANÁLISES CLÍNICAS

    OpenAIRE

    Jaqueline HECK; Letícia Fernanda GIOMBELLI; Jean COLACITE; Cibeli Lunardeli OLIVEIRA

    2015-01-01

    A próstata é a glândula do sistema reprodutor masculino, responsável por produzir o liquido seminal, podendo ser acometida pela hiperplasia prostática benigna, câncer e prostatite, sendo diagnosticados pelo toque retal, associado com os níveis elevados do Antígeno Prostático Especifico (PSA). A hiperplasia tem como sintomas o prostatismo, que provoca obstrução e sintomas irritativos. Já o câncer apresenta a ausência de sintomas na fase inicial da doença, apenas com sintomas semelhantes à hipe...

  3. MAL2 and tumor protein D52 (TPD52) are frequently overexpressed in ovarian carcinoma, but differentially associated with histological subtype and patient outcome

    International Nuclear Information System (INIS)

    The four-transmembrane MAL2 protein is frequently overexpressed in breast carcinoma, and MAL2 overexpression is associated with gain of the corresponding locus at chromosome 8q24.12. Independent expression microarray studies predict MAL2 overexpression in ovarian carcinoma, but these had remained unconfirmed. MAL2 binds tumor protein D52 (TPD52), which is frequently overexpressed in ovarian carcinoma, but the clinical significance of MAL2 and TPD52 overexpression was unknown. Immunohistochemical analyses of MAL2 and TPD52 expression were performed using tissue microarray sections including benign, borderline and malignant epithelial ovarian tumours. Inmmunohistochemical staining intensity and distribution was assessed both visually and digitally. MAL2 and TPD52 were significantly overexpressed in high-grade serous carcinomas compared with serous borderline tumours. MAL2 expression was highest in serous carcinomas relative to other histological subtypes, whereas TPD52 expression was highest in clear cell carcinomas. MAL2 expression was not related to patient survival, however high-level TPD52 staining was significantly associated with improved overall survival in patients with stage III serous ovarian carcinoma (log-rank test, p < 0.001; n = 124) and was an independent predictor of survival in the overall carcinoma cohort (hazard ratio (HR), 0.498; 95% confidence interval (CI), 0.34-0.728; p < 0.001; n = 221), and in serous carcinomas (HR, 0.440; 95% CI, 0.294-0.658; p < 0.001; n = 182). MAL2 is frequently overexpressed in ovarian carcinoma, and TPD52 overexpression is a favourable independent prognostic marker of potential value in the management of ovarian carcinoma patients

  4. Ação do radium sôbre o vírus da Coriomeningite linfocitária benigna Radium effect upon the lymphocytic choriomeningitis virus

    Directory of Open Access Journals (Sweden)

    J. Guilherme Lacorte

    1968-01-01

    Full Text Available O presente trabalho faz parte de uma seqüência iniciada em 1953 com a verificação do efeito dos raios X sôbre o vírus da gripe em que observamos que os mesmos, em doses fracas, tem aumentado o seu poder patogênico para camundongos. Posteriormente, verificamos a ação do radium sôbre o vírus da gripe e da poliomielite. Neste último caso, o vírus irradiado mostrou-se ativo durante maior número de dias. Nas pesquisas aqui referidas, submetemos o vírus da coriomeningite linfocitária benigna a ação do radium, usando quatro agulhas de 1 mg desse elemento em dispositivo que idealizamos para êste fim. Depois de irradiada, foi a suspensão de vírus diluida a 10*-1, 10*-2 e 10*-3 para as inoculações em camundongos, juntamente com as diluições testemunhas. Observamos que o vírus resistiu pelo menos 264 dias, à temperatura de 4ºC. Quanto às alterações do poder patogênico provocadas pelo radium verificamos que o mesmo não se altera após 24 horas de irradiação. Diminue após 8 dias para aumentar, de modo seguro, após 20 e 33 dias. Iguala-se ao testemunha depois de 78 dias.In the present paper the authors refered the experiments made with the lymphocytic chriomeningitis virus. We strain, after exposition to 4 tubes of 1 mg of radium. The virus suspension was put into the Carrel flask in a layer of 0,1 cm. The titrations of the irradiated virus suspension were made after 24 hours, 8, 20, 33, 78, 85, 120, 264, 292, 387 and 535 days. the virus was still active after 264 days, not after 292 days. The virus irradiated during 24 hours presented the same pathogenicity form mice than the control but after 8 days it was lesser and after 20 and 33 days it was enchanced (Graphic 10. After 78 days the pathogenic power was the same for the irradiated virus and the control.

  5. Aspectos clínicos e funcionais do equilíbrio corporal em idosos com vertigem posicional paroxística benigna Clinical and functional aspects of body balance in elderly subjects with benign paroxysmal positional vertigo

    Directory of Open Access Journals (Sweden)

    Daniela Patricia Vaz

    2013-04-01

    Full Text Available Vertigem Posicional Paroxística Benigna (VPPB pode alterar o equilíbrio corporal em pacientes idosos. OBJETIVO: Observar os efeitos da manobra de Epley em idosos com VPPB, avaliando os aspectos clínicos e funcionais do equilíbrio corporal. Forma de estudo: clínico e prospectivo. MÉTODO: Após o diagnóstico da doença (teste de DixHallpike, os testes Time Up and Go (TUGT, Clinical test of Sensory Interaction and Balance (CTSIB e o teste de membros inferiores (MMI foram realizados antes e após a manobra de reposicionamento de Epley modificada. RESULTADOS: O gênero feminino foi o mais prevalente e a média etária foi de 70,10 anos (DP = 7,00. Todos os pacientes apresentaram ductolitíase de canal posterior. Os seguintes sintomas melhoraram após a manobra: a instabilidade postural (p = 0,006, náusea e vômito (p = 0,021 e zumbido (p = 0,003. Em relação ao TUGT e o escore do teste de MMII, observou-se diminuição significante do tempo pós-manobra de Epley (p Benign paroxysmal positional vertigo (BPPV may compromise the balance of elderly subjects. OBJECTIVE: To observe the effects of the Epley maneuver in elderly subjects with BPPV and assess clinical and functional aspects of body balance. METHOD: This is a prospective clinical study. Patients diagnosed with BPPV (Dix-Hallpike test were submitted to the Timed Up & Go (TUG test, the Clinical Test of Sensory Interaction and Balance (CTSIB, and lower limb testing before and after they were repositioned using the modified Epley maneuver. RESULTS: Most subjects were females, and the group's mean age was 70.10 years (SD = 7.00. All patients had canalithiasis of the posterior canal. The following symptoms improved after the maneuver: postural instability (p = 0.006, nausea and vomiting (p = 0.021, and tinnitus (p = 0.003. Subjects improved their times significantly in the TUG and lower limb tests after the Epley maneuver (p < 0.001. Patients performed better on the CTSIB after the Epley

  6. L'espace du mal et le mythe indo-européen dans le Rolandslied

    OpenAIRE

    Stablein, Patricia Harris

    2014-01-01

    A travers la figuration de Ganelon, douée d'une ampleur remarquable dans le Rolandslied (RL) du Prêtre Konrad (oeuvre qui date de la fin du douzième siècle), nous voyons surgir les narrations de la Passion et du Dernier Jugement qui soutendent la predication de cette épopée romane en moyen haut allemand. Mais la forme de Ganelon révèle ici un autre dessin, celui du mal indo-européen. Au moment de sa nomination à l'office du messager, le wuluine blicke (v. 1418) de Ganelon révèle son incarnati...

  7. Musique du mal, musique du bien dans le théâtre baroque

    OpenAIRE

    Wolf, Robert Erich

    2012-01-01

    Si on cherche le fondement moral commun à la plupart des pièces de théâtre baroques, on le trouvera, il me semble, dans le conflit entre le Bien et le Mal. À l’époque baroque ce conflit prend la forme du débat, du dialogue, de la dialectique ; et, comme il arrive souvent dans l’art, l’opposition entre valeurs morales - ou psychologiques, ce qui au théâtre est équivalent - détermine en grande partie la forme de la pièce : on peut dire même qu’elle forme la pièce. Ce qui distingue l’art théâtra...

  8. Malé jednoválcové spalovací motory

    OpenAIRE

    Smolka, Josef

    2015-01-01

    Obsahem této práce je seznámit čtenáře s použitými technickými řešeními v oblasti malých jednoválcových motorů a stručný přehled alternativních paliv pro zážehové motory. Hlavním cílem je nabídnout ucelený přehled dostupných motorů a jejich parametrů. The content of this thesis is getting to know the reader with the technical solutions in the field of small single cylinder engines and a brief overview of alternative fuels for petrol engines. The main objective is to offer a comprehensive o...

  9. SmartMal: A Service-Oriented Behavioral Malware Detection Framework for Mobile Devices

    Directory of Open Access Journals (Sweden)

    Chao Wang

    2014-01-01

    Full Text Available This paper presents SmartMal—a novel service-oriented behavioral malware detection framework for vehicular and mobile devices. The highlight of SmartMal is to introduce service-oriented architecture (SOA concepts and behavior analysis into the malware detection paradigms. The proposed framework relies on client-server architecture, the client continuously extracts various features and transfers them to the server, and the server’s main task is to detect anomalies using state-of-art detection algorithms. Multiple distributed servers simultaneously analyze the feature vector using various detectors and information fusion is used to concatenate the results of detectors. We also propose a cycle-based statistical approach for mobile device anomaly detection. We accomplish this by analyzing the users’ regular usage patterns. Empirical results suggest that the proposed framework and novel anomaly detection algorithm are highly effective in detecting malware on Android devices.

  10. Spectroscopic study of Mq3 (M=Al, Ga, In, q=8-hydroxyquinolinate) at high pressure

    International Nuclear Information System (INIS)

    A high-pressure spectroscopic investigation of OLED materials with generic formula Mq3 (M=Al, Ga, In, q=8-hydroxyquinolinate) has been carried out. The meridional isomer of Alq3, Gaq3, Inq3 and facial isomer of Alq3 have been produced and their corresponding photoluminescence emission energy has been studied as a function of the cation, pressure, excitation wavelength and isomer. A redshift in the order of 0.3 eV takes place for the pure-meridional isomer compounds in the 0-8 GPa range. We have detected the occurrence of pressure-induced phase transitions presenting hysteresis to ambient conditions. In the case of the facial isomer, luminescence does not significantly redshift until very high pressure. We interpret these features in terms of the enhancement of the intermolecular interaction.

  11. Mal de Debarquement Syndrome: A Rare Entity—A Case Report and Review of the Literature

    Directory of Open Access Journals (Sweden)

    Veronica Nwagwu

    2015-01-01

    Full Text Available Mal de Debarquement Syndrome (MDS is a rare, understudied, underdiagnosed, and self-limiting condition. Etiology and incidence are unknown. It is characterized by abnormal sensation of motion/balance reported after travel by air, land, and sea; being reexposed to motion/activity relieves it. Symptoms may last from minutes to years. Workup though required reveals no findings; it is a diagnosis of exclusion. While no efficacious treatment exists, amitriptyline and benzodiazepines as well as supportive therapy have proved to be useful. We have described a 40-year-old Caucasian female who presented for the evaluation of persistent rocking and swaying sensation after a ship cruise which lasted for one week. Patient was treated with benzodiazepines after extensive workup and is now stable. A high index of suspicion is required to make a diagnosis.

  12. Měnič pro malý 3f asynchronní motor

    OpenAIRE

    Pavlík, Ondřej

    2011-01-01

    Cílem této bakalářské práce je navrhnout třífázový frekvenční měnič malého výkonu 100 W pro napájení asynchronního motoru. Zařízení je vhodné pro konstrukci s ventilátory. Návrh byl optimalizován z hlediska nízké ceny a technické proveditelnosti. Zařízení je možné použít v méně náročných aplikacích, kde tomu doposud bránila vysoká cena běžných frekvenčních měničů.

  13. ACCUMULATION OF POLYHYDROXYALKANOIC ACIDS BY AZOTOBACTER CHROOCOCCUM MAL-201 FROM ORGANIC WASTE

    Directory of Open Access Journals (Sweden)

    Soma Pal Saha

    2013-08-01

    Full Text Available Azotobacter chroococcum MAL-201 (MTCC 3853, a free-living nitrogen-fixing bacterium accumulated intracellular poly(3-hydroxybutyric acid [P(3HB] accounting 69% of cell dry weight (CDW when grown in nitrogrn-free Stockdale medium containing 2% (w/v glucose. It also produced copolymer of poly(3-hydroxybutyrate co-3-hydroxyvalerate [P(3HB-co-3HV] using glucose as primary carbon source and valerate cas cosubstrate. To make the polymer production cost effective four types of waste material of different origin were tested for growth and polymer production. Stockdale medium supplemented with 1% (w/v waste materials failed to yield good growth and polymer accumulation. Two–step cultivation was adopted for better growth and enhanced polymer accumulation. The candy factory waste was most suitable for synthesis of P(3HB accounting 17.8 and 40.58% using single and two-step cultivation conditions respectively. Wastes of domestic and poultry origin produced P(3HB-co-3HV with 3HV content 28.8 and 21.5 mol% respectively in two-step cultivation. Increase concentration of these wastes resulted in further upliftment of 3HV content of polymer with reduced growth and polymer accumulation. However, at optimum incubation the strain MAL-201 cells accumulated P(3HB 48.5% of CDW (at 40h from candy factory waste and P(3HB-co-3HV 24.75 % of CDW with 3HV 34.65 mol % from domestic waste. Intrinsic viscosity, molecular weight and thermal degradation of the polymers accumulated in the cells grown in glucose, glucose with valerate and glucose with waste were compared.

  14. Bhaktapur, Nepal: the MAL-ED birth cohort study in Nepal.

    Science.gov (United States)

    Shrestha, Prakash Sunder; Shrestha, Sanjaya Kumar; Bodhidatta, Ladaporn; Strand, Tor; Shrestha, Binob; Shrestha, Rita; Chandyo, Ram Krishna; Ulak, Manjeswori; Mason, Carl J

    2014-11-01

    The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) cohort study site in Nepal is located in the Bhaktapur municipality, 15 km east of Kathmandu, the capital city of Nepal. Bhaktapur, an ancient city famous for its traditional temples and buildings, is included on UNESCO's World Heritage List and is a major tourist attraction in Nepal. Nepal is a land-locked country located in South Asia between China and India with an area of 147 181 km(2), ranging from sea-level plains to Mount Everest, the world's highest peak. The total population as of the 2011 census was 26.6 million, with an average annual population growth rate of 1.4. Nepal is one of the world's least developed countries and is ranked 157 of 186 in the 2013 Human Development Report; one-third of the Nepali population lives below the poverty line. The current under-5 mortality rate is 54 per 1000 live births, the infant mortality rate is 46 per 1000 live births, and the neonatal mortality rate is 33 per 1000 live births. Vaccine coverage for all Expanded Program on Immunization vaccines is >80%. Among children, the most common diseases contributing to significant morbidity and mortality are acute respiratory infection and dehydration from severe diarrhea. In this article, we report on the geographic, demographic, and socioeconomic features of the Bhaktapur MAL-ED site and describe the data that informed our cohort recruitment strategy. PMID:25305301

  15. CADM1 and MAL methylation status in cervical scrapes is representative of the most severe underlying lesion in women with multiple cervical biopsies.

    Science.gov (United States)

    van Baars, Romy; van der Marel, Jacolien; Snijders, Peter J F; Rodriquez-Manfredi, Agata; ter Harmsel, Bram; van den Munckhof, Henk A M; Ordi, Jaume; del Pino, Marta; van de Sandt, Miekel M; Wentzensen, N; Meijer, Chris J L M; Quint, Wim G V

    2016-01-15

    Recent studies have shown that CADM1/MAL methylation levels in cervical scrapes increase with severity and duration of the underlying cervical intraepithelial neoplasia (CIN) lesion. Multiple lesions of different histological grades and duration are frequently present on the cervix. To gain more insight into the possible epigenetic heterogeneity and its consequences for the methylation status in cervical scrapes, we performed an exploratory study of CADM1/MAL methylation in different grades of CIN lesions present in women with multiple cervical biopsies. CADM1-M18 and MAL-M1 methylation was assessed using a standardised, multiplex, quantitative methylation specific PCR on 178 biopsies with various grades of CIN in 65 women, and in their corresponding cervical scrapes. CADM1/MAL methylation positivity increased with disease severity, from 5.5% in normal biopsies to 63.3% and 100% in biopsies with CIN3 and cervical cancer, respectively. In the majority (8/9) of women where besides a CIN2/3 lesion a biopsy from normal cervical tissue was present, the CIN2/3 biopsy was CADM1/MAL methylation positive and the normal biopsy was CADM1/MAL methylation negative. A good concordance (78%) was found between CADM1/MAL methylation results on the scrapes and the biopsy with the worst diagnosis, particularly between samples of women with CIN3 and cervical cancer (92% and 100% concordance, respectively). Thus, in women with multiple cervical biopsies, CADM1/MAL methylation increases with severity of the lesion and is lesion-specific. CADM1/MAL methylation status in cervical scrapes appears to be representative of the worst underlying lesion, particularly for CIN3 and cervical cancer. PMID:26219541

  16. Le problème du mal dans le Guide des Perplexes et son arrière-plan talmudique

    Directory of Open Access Journals (Sweden)

    Costa, José

    2010-12-01

    Full Text Available At first sight, the question of evil is regarded in the Guide for the Perplexed in a paradoxical manner. Thus, in Guide I, 2, Maimonides examines the notions of good and evil as subjective evaluations possessing neither the rigour not the exactness of the notions of true and false. However, the question of evil occupies an essential place in the Guide, as various modern authors have shown. This question is important to Maimonides because he is, in this respect, the heir of the rabbinic tradition and his conception of evil is largely based on an interaction with the Talmudic and Midrašic texts. Therefore, we would like to review thirty-nine rabbinic ‘quotes’ which appear in chapters 8 to 24 in the third part of the Guide and deal with the origin of evil, the meaning of suffering and the evil inclination. Maimonides reappropriates the midrašim that are susceptible of being in agreement with his rationalist positions and also quotes some rabbinic traditions that are too close to mu ͑tazilism, undoubtedly aware of the more profound resemblance that exists between the rabbinic and mu ͑tazilite doctrines of evil and retribution.A primera vista, el problema del mal es abordado en la Guía de Perplejos de manera paradójica. Para Maimónides, las nociones de bien y mal son subjetivas y no resultan ni rigorosas ni exactas, a la inversa de las nociones de verdad y falsedad (Guía I, 2. Sin embargo, el problema del mal es muy importante en la Guía, como lo demostraran varios autores. Maimónides es el heredero de la tradición rabínica y existe en la Guía una interacción entre la filosofia de Maimónides y los textos talmúdicos y midrásicos. Es particularmente el caso de las treinta y nueve citas rabínicas de la Guía II, 8-24, que tratan del origen del mal, del significado del sufrimiento y de la inclinación al mal. Maimónides cita los midrašim que concuerdan con sus posiciones racionalistas y evoca también algunas tradiciones rab

  17. Endocrinopatías en gatos diagnosticadas entre marzo de 2003 y marzo de 2011 en el Hospital Escuela de Medicina Veterinaria de la Facultad de Ciencias Veterinarias, Universidad de Buenos Aires Endocrinopathies in cats diagnosed between March 2003 and March 2011 in the Veterinary school Hospital, Faculty of Veterinary Science, University of Buenos Aires

    OpenAIRE

    M.M Zapata; Castillo, V A

    2011-01-01

    El objetivo de este estudio fue analizar la frecuencia de presentación de endocrinopatías diagnosticadas en la Unidad de Endocrinología del Hospital Escuela en el período comprendido entre marzo de 2003 y marzo de 2011. Se revisaron las historias clínicas de 40 gatos diagnosticados con diversas endocrinopatías. La diabetes mellitus representó el 47,5% (19/40) de los casos, el hipertiroidismo el 20% (8/40), el hipotiroidismo el 15% (6/40) y el SC el 10% (4/40), siendo los desórdenes endócrinos...

  18. La inclusión social por la vía del cuerpo en mujeres diagnosticadas con anorexia bulimia en la ciudad de Medellín, Colombia = Social inclusion through the body in women with anorexia-bulimia in Medellín, Colombia

    OpenAIRE

    Marín Cortés, Andrés Felipe; Bedoya Hernández, Mauricio Hernando

    2010-01-01

    Este informe presenta los hallazgos de la investigación "Narrativas identitarias sobre la vivencia corporal en mujeres diagnosticadas con trastorno de la alimentación" efectuada en Medellín.Objetivo: reconocer cómo el significado atribuido a la vivencia corporal devela la construcción de la identidad en mujeres con trastornos de la alimentación.Metodología: enfoque cualitativo, con diseño de casos múltiples analizados mediante los procedimientos del método fenomenológico-hermenéutico. Se hici...

  19. Epilepsia"Petit Mal" aspectos clínicos, eletrencefalográficos e evolutivos

    Directory of Open Access Journals (Sweden)

    Paulo Pinto Pupo

    1961-01-01

    Full Text Available In the past few years somewhat new yet often differing points of view have been affirmed refering to Petit Mal epilepsy, with regard to its clinical, eletrencephalographic and evolutive aspects. The classical concept of PM epilepsy as established by Lennox and Gibbs, with its well defined clinical and EEGraphic characteristics is continually being modified with new research work on clinical and EEGraphic aspects. Numerous clinical cases have been published whose evolution clashes with that classically described and likewise numerous are those cases where the EEG shows signs of focal electric activity besides spike and wave dis-rythmia. Cases have been known where surgical exerese on the focus causes temporary desappearance of the spike and wave disrythmia. The present concept now holding sway is that PM epilepsy is a kind of reaction of infantile encephalon to diverse harmful causes. From this it will be seen we are very far from the concept that PM epilepsy is a pure form of idiopathic epilepsy. For these reasons we decided to re-examine those cases observed between 1950 and 1960. With this in mind we chose 141 PM epilepsy cases, from among over 23000 epileptics, all examined under a standard criterion by a small group of senior assistants. All cases suspected of Psm epilepsy were excluded. The analysis of this group of patients was compared to that of another group with GM as well as PM seizures (104 patients; in 52 of these cases, studies were made concerning the evolutive, clinical and EEGra-phic aspects. METHOD: Clinical criterion was used for selection of the cases. The results of the analysis from the clinical and EEGraphic point of view were exhibited in demonstrative graphs. From the clinical point of view we strove to find out positive hereditary elements, organic cerebral injury factor (intellectual deficit, mood and behaviour disturbances, neurologic or somatic signs, as well as other development anomalies, the presence of febrile

  20. Efeito da manobra de Epley na qualidade de vida dos pacientes com vertigem posicional paroxística benigna Effect of Epley's maneuver on the quality of life of paroxismal positional benign vertigo patients

    Directory of Open Access Journals (Sweden)

    Alcione Botelho Pereira

    2010-12-01

    Full Text Available A vertigem produz impactos significativos na qualidade de vida (QV. É necessário mensurar os efeitos das terapêuticas antivertiginosas na QV. OBJETIVO: Investigar o efeito da manobra de reposicionamento na qualidade de vida de pacientes com vertigem posicional paroxística benigna (VPPB. MATERIAL E MÉTODOS: Estudo retrospectivo, através da revisão dos prontuários de 21 pacientes com VPPB atendidos no serviço de Reabilitação Vestibular (RV de uma clínica escola de Belo Horizonte atendidos em 2007-2008. Foram analisados os escores físicos, funcionais e emocionais, pré e pós-terapia de RV com realização de manobras de reposicionamento de Epley, por meio do questionário Dizziness Handicap Inventory (DHI, específico para avaliação da interferência da tontura na QV. RESULTADOS: O intervalo mediano entre as avaliações foi de 21 dias. O número médio de manobras foi 2,3±1,1. A aplicação do DHI mostrou um significante impacto da VPPB na QV dos pacientes em todas as dimensões da vida diária, com os seguintes escores médios pré e pós-terapia: físico (17,5/3,7, funcional (17,3/3,9, emocional (13,2/3,2 e total (48,1/10,9, respectivamente (pQuality of life (QoL is significantly impaired by vertigo. The effect of specific treatments on QoL deserves investigation. AIM: To assess the effect of repositioning maneuvers on the QoL of benign paroxysmal positioning vertigo (BPPV patients. MATERIALS AND METHODS: A retrospective study design consiting of reviews of charts of BPPV patients in a vestibular rehabilitation unit at a teaching institution in Belo Horizonte, MG, Brazil, from 2007 to 2008. Pre- and post-therapy (Epley's repositioning maneuver scores on the physical, functional and emotional dimensions of the Dizziness Handicap Inventory (DHI were analyzed. RESULTS: Twenty-one patients were included, eighteen (86% were females; the average age was 53.2 years. Ten patients presented bilateral BPPV; in eleven it was unilateral

  1. DMPD: The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 17449723 The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling. Sh...eedy FJ, O'Neill LA. J Leukoc Biol. 2007 Aug;82(2):196-203. Epub 2007 Apr 20. (.png) (.svg) (.html) (.csml) Show The... Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling. PubmedID 17449723 Title The Tro

  2. Structural and magnetic properties of UFexM12-x (M=Al, Mo and Si) intermetallic compounds

    International Nuclear Information System (INIS)

    The U-Fe-M, M=Al, Mo and Si, phase diagrams around UFexM12-x compositions were investigated in order to find congruent melting compounds with ThMn12-type structure. This structure was confirmed in all cases by single crystal X-ray diffraction and lattice parameters and occupation factors were calculated. Magnetisation measurements performed on single crystals and polycrystalline samples are reported. ((orig.))

  3. Malária por Plasmodium falciparum: estudos proteômicos Plasmodium falciparum malaria: proteomic studies

    Directory of Open Access Journals (Sweden)

    Rodrigo Siqueira-Batista

    2012-12-01

    Full Text Available A despeito dos avanços no tratamento e das campanhas de prevenção e de controle da malária nos distintos continentes nos quais a moléstia grassa, a entidade mórbida permanece com significativa relevância no mundo contemporâneo. O Plasmodium falciparum é o grande responsável pela malária grave, caracterizada por distúrbios em diferentes órgãos e sistemas, com possibilidade de evolução ao óbito. Embora incipientes, os estudos proteômicos na malária têm trazido boas perspectivas para melhor compreensão dos aspectos biológicos do Plasmodium, assim como dos mecanismos fisiopatológicos, diagnósticos, terapêuticos e profiláticos da enfermidade. Desse modo, o objetivo do presente artigo é apresentar uma breve revisão das aplicações da análise proteômica na malária por P. falciparum.Despite advances in treatment and campaigns for prevention and control of malaria on the various continents where it is still rampant, this disease remains significantly relevant to the contemporary world. Plasmodium falciparum is the organism that is mainly responsible for severe malaria, which is characterized by disturbances in different organs and systems, with possibly fatal outcomes. Although incipient, proteomic studies of malaria have yielded favorable prospects for elucidating the biological aspects of Plasmodium as well as the pathophysiological, diagnostic, prophylactic, and therapeutic mechanisms of the disease. Thus, the aim of the present article is to present a brief review of the applications of proteomic analysis in P. falciparum malaria.

  4. Estudo clínico da malária falciparum em crianças em Manaus, AM, Brasil

    Directory of Open Access Journals (Sweden)

    Noronha Elza

    2000-01-01

    Full Text Available As características clínicas da malária falciparum foram estudadas em 61 crianças com idade de 0 a 14 anos, atendidas em centro de referência em Manaus, entre outubro e dezembro de 1997. Os sintomas encontrados foram febre (98,4%, cefaléia (80,3%, calafrios (68,9%, sudorese (65,6%, mialgia (59%, náuseas (54,1%, lombalgia (49,2%, vômitos (49,2%, tosse (45,9%, artralgia (31,1%, diarréia (34,4%, dispnéia (8,2%, convulsões (8,2% e tonturas (4,9%. Palidez cutâneo-mucosa e anemia foram observadas mais freqüentemente nas crianças menores de 5 anos. A anemia esteve asssociada aos maiores níveis de parasitemia. Cinqüenta e oito (91,5% pacientes apresentaram malária não complicada, 3 (4,9% malária grave e a letalidade foi 1,6%.

  5. Malé a střední jaderné reaktory a jejich využití

    OpenAIRE

    Novotný, Filip

    2012-01-01

    Bakalářská práce se zaměřuje na oblast malých a středních jaderných reaktorů, na jejich roli při počátečním vývoji jaderné energetiky. Shrnuje současné malé a střední reaktory v provozu a zamýšlí se nad budoucím vývojem v této oblasti. Analyzuje možnosti jejich využití a aplikace v různých oblastech lidské činnosti. Soustředí se na nové projekty malých a středních reaktorů, s důrazem na projekty dostupné v nejbližší době. Hodnotí odolnost proti šíření jaderných zbraní, ekonomické a technické ...

  6. Synthesis and Crystal Structure of a Novel 2D Coordination Polymer [Cu3(mal)2(di-2-pyridlyktone)2

    Institute of Scientific and Technical Information of China (English)

    ZHANG Mei-Li; WU Ya-Pan; WANG Ji-Jiang; REN Yi-Xia; CHEN Xiao-Li

    2011-01-01

    A novel coordination polymer of CuⅡ with flexible ligands, namely, [Cu3(mal)2(di2-pyridlyktone)2] (1, H2mal = maleie acid), was synthesized and characterized by single-crystal X-ray diffraction, thermogravimetric analyses, elemental analysis and IR spectroscopy. The structure indicates that the complex crystallizes in monoclinic, space group P21/c with a = 10.268(2), b =17.737(3), c = 8.038(1) (A), β = 98.275(2)°, V = 1448.6(4) (A)3, Z = 2, Dc = 1.883 Mg·m-3, μ = 2.260 mm-1, F(000) = 826, and the final R = 0.0321 and wR = 0.0820. In 1, three CuⅡ centers (Cu(1),Cu(2), Cu(1A)) are bridged by two uncommonμ3-bridging H2mal ligands, furnishing a centrosymmetric trimetallic unit. Via further Cu-Ocoo coordination interactions, extention of these trimetallic units in two directions gives rise to an infinite corrugated 2D layer. In addition, thermal stability and electrochemistry of 1 were studied.

  7. Recombinant Mal d 1 facilitates sublingual challenge tests of birch pollen-allergic patients with apple allergy.

    Science.gov (United States)

    Kinaciyan, T; Nagl, B; Faustmann, S; Kopp, S; Wolkersdorfer, M; Bohle, B

    2016-02-01

    It is still unclear whether allergen-specific immunotherapy (AIT) with birch pollen improves birch pollen-related food allergy. One reason for this may be the lack of standardized tests to assess clinical reactions to birch pollen-related foods, for example apple. We tested the applicability of recombinant (r) Mal d 1, the Bet v 1-homolog in apple, for oral challenge tests. Increasing concentrations of rMal d 1 in 0.9% NaCl were sublingually administered to 72 birch pollen-allergic patients with apple allergy. The dose of 1.6 μg induced oral allergy syndromes in 26.4%, 3.2 μg in 15.3%, 6.3 μg in 27.8%, 12.5 μg in 8.3%, 25 μg in 11.1%, and 50 μg in 4.2% of the patients. No severe reactions occurred. None of the patients reacted to 0.9% NaCl alone. Sublingual administration of 50 μg of rMal d 1 induced no reactions in three nonallergic individuals. Our approach allows straight forward, dose-defined sublingual challenge tests in a high number of birch pollen-allergic patients that inter alia can be applied to evaluate the therapeutic efficacy of birch pollen AIT on birch pollen-related food allergy. PMID:26443126

  8. FRIENDSHIP TO NIETZSCHE: AN ARENA OF MISUNDERSTANDINGS A AMIZADE PARA NIETZSCHE: UMA ARENA DE MAL ENTENDIDOS

    Directory of Open Access Journals (Sweden)

    Jelson Roberto de Oliveira

    2011-12-01

    Full Text Available This article intended to show the importance of friendship in the context of reflection on the incomprehensibility of living wealth experienced as more intimate experience and how Nietzsche comes, with the relationship amicable, to formulating of a new dawn of thought, now situated in the field of experience which escapes of systems responsiveness. In this scenario, friendship appears as a ring for misunderstandings because it fosters the possibility of a relationship translated by the plural pronoun us - a sign of relationship that is effective as fearlessness, freedom and assert themselves, with a view to constant self-overcoming.

    Pretende-se mostrar a importância da amizade no âmbito da reflexão sobre a incompreensibilidade da riqueza vital experimentada como vivência mais própria e como Nietzsche chega, pela relação amical, à formulação de uma nova aurora do pensar, agora situado no campo das vivências cuja tradução foge dos sistemas da compreensibilidade. Nesse cenário, a amizade aparece como arena para mal entendidos porque fomenta a possibilidade de uma relação traduzida pelo pronome plural nós – um signo da relação que se efetiva como impavidez, liberdade e afirmação individual, com vistas à constante autossuperação de si.

  9. Quema de libros y antitotalitarismo. Manuel Rivas Los libros arden mal y Ray Bradbury Fahrenheit 451

    Directory of Open Access Journals (Sweden)

    Mechthild Albert

    2016-07-01

    Full Text Available The current article aims at a comparison of Manuel Rivas’ Los libros arden mal (2006 and Ray Bradbury’s Fahrenheit 451 (1953. Both novels share the anti-totalitarian commitment which is, in both cases, exemplified by the book burning motive, considered the climax of anti-cultural barbarism. Based on Fernando Rodríguez de la Flor’s reflections on biblioclasm (2004, parallels can be found in the following aspects: the zoo- and anthropomorphic description of the burning books; biblioclasm as an expression of totalitarianism, indicating, furthermore, an ambivalent and dialectic relation between civilization and barbarism; the subversive movements dedicated to maintain the reverence for the book and the philosophical-literary tradition; the intertextuality and the prominent role of the Bible as the Book of books. In conclusion, one can say that both authors, despite various common points – especially with regard to their anti-totalitarian commitment – differ, in particular, in terms of their political orientation and the focus of their cultural critic

  10. O uso da difusão por ressonância magnética na diferenciação das lesões mamárias benignas e malignas The use of diffusion-weighted magnetic resonance imaging in the differentiation between benign and malignant breast lesions

    OpenAIRE

    Fernanda Philadelpho Arantes Pereira; Gabriela Martins; Eduardo Figueiredo; Marisa Nassar Aidar Domingues; Romeu Côrtes Domingues; Lea Mirian Barbosa da Fonseca

    2009-01-01

    OBJETIVO: Estudar a utilidade da sequência pesada em difusão na diferenciação das lesões mamárias benignas e malignas. MATERIAIS E MÉTODOS: Quarenta e cinco mulheres (idade média de 46,1 anos) com 52 nódulos de mama foram submetidas a ressonância magnética acrescida da sequência difusão. O coeficiente de difusão aparente (ADC) foi calculado através do mapa de ADC obtido pelo uso de cinco valores de b (0, 250, 500, 750 e 1.000 s/mm²). O valor de ADC médio de cada lesão foi correlacionado com a...

  11. Effect of play therapy on behavioral problems of mal-adjusted pre-school children

    Directory of Open Access Journals (Sweden)

    Mehdi Khanbani

    2011-01-01

    Full Text Available Objective: The present research was conducted to study the effect of play therapy on reducing behavioral problems of mal-adjusted children (children with oppositional defiant disorder. Method: By using multistage cluster sampling, regions 6, 7, and 8 in Tehran were selected, and among kindergartens of these areas, 3 kindergartens under the support of welfare organization were randomly selected. From pre-school children of these 3 kindergartens, 40 children that could have behavioral disorder according to their teachers and parents complaints, were carefully tested, and among them, by the results obtained from child symptom inventory questionnaire (CSI-4, teacher's form, and a researcher-made self-control checklist, 16 children who showed severe symptoms of oppositional defiant disorder were selected, and they were randomly divided into control and experimental group. This research is quasi-experimental, and is done by the use of pre-test, post-test, and control group. Results: values of calculated F for oppositional defiant disorder in control and experimental group is meaningful after fixing the effect of pre-test (F(1,12=74/94, P<0/001 so there is a meaningful difference between means of disobedience disorder post-test scores in experimental and control group by having the fixed effect of pre-test effect. Comparison of adjusted means of 2 groups shows that the mean of attention-deficit hyperactivity disorder (ADHD in experimental group (M=14/09 is lower than control group (M=36/66. Therefore, applying play therapy in experimental group in comparison with control group, who did not receive these instructions, caused reduction in attention-deficit hyperactivity disorder (ADHD in pre-school children. Conclusion: Results of this research show that the children's disobedience is reduced by benefiting from play therapy.

  12. Simulação no contexto de problemas mal estruturados

    Directory of Open Access Journals (Sweden)

    Antônio Sérgio de Souza

    1994-12-01

    Full Text Available Simulação é atualmente reconhecida como uma poderosa ferramenta no projeto, análise e operação de sistemas produtivos. Apesar dos avanços recentes em linguagens de simulação, interfaces gráficas e geradores de aplicações, simulação ainda é uma técnica cara e pouco eficiente. Discute-se no texto algumas causas deste fato no contexto de problemas mal estruturados, como é o caso de planejamento e controle da produção. Discute-se a necessidade de realização da modelagem conceitual, não apenas como um passo estanque no processo de simulação, mas de forma progressiva e dinâmica, durante todo o ciclo de vida do projeto, servindo como uma interface entre os contextos real e de simulação.Simulation is now recognized as powerful tool in project, analyses and operation of produtive systems. Although the recent advances in simulation languages, graphical interfaces and in generating applications, simulation is still an expensive and not so efficient technique. In this text we dicuss some reasons for this in the context of not well strutured problems, asit is the case of production planning and control. It is also dicussed the necessity of developing the conceptual modeling of the real system, not only as a separated step in the simulation process, but in a progressive and dynamic way, during the project's life cycle as an interface between the real system and simulation.

  13. Early interruption of exclusive breastfeeding: results from the eight-country MAL-ED study.

    Science.gov (United States)

    Patil, Crystal L; Turab, Ali; Ambikapathi, Ramya; Nesamvuni, Cebisa; Chandyo, Ram Krishna; Bose, Anuradha; Islam, M Munirul; Ahmed, A M Shamsir; Olortegui, Maribel Paredes; de Moraes, Milena Lima; Caulfield, Laura E

    2015-01-01

    We report the infant feeding experiences in the first month of life for 2,053 infants participating in "Malnutrition and Enteric Infections: Consequences for Child Health and Development" (MAL-ED). Eight sites (in Bangladesh, India, Nepal, Pakistan, Brazil, Peru, South Africa, Tanzania), each followed a cohort of children from birth (by day 17), collecting detailed information on infant feeding practices, diet and illness episodes. Mothers were queried twice weekly regarding health status, breastfeeding and the introduction (or no) of non-breast milk liquids and foods. Here, our goal is to describe the early infant feeding practices in the cohort and evaluate factors associated with termination of exclusive breastfeeding in the first month of life. With data from enrollment to a visit at 28-33 days of life, we characterized exclusive, predominant or partial breastfeeding (using a median of 6-9 visits per child across the sites). Only 6 of 2,053 infants were never breastfed. By one month, the prevalences of exclusive breastfeeding were  20% in 6 of 8 sites. Logistic regression revealed that prelacteal feeding (given to 4-63% of infants) increased the likelihood of partial breastfeeding (Odds Ratio (OR): 1.48 (95% confidence interval (CI): 1.04, 2.10), as did the withholding of colostrum (2-16% of infants) (OR: 1.63:1.01, 2.62), and being a first-time mother (OR: 1.38:1.10, 1.75). Our results reveal diversity across these sites, but an overall trend of early transition away from exclusive breastfeeding in the first month of life. Interventions which introduce or reinforce the WHO/UNICEF Ten Steps for Successful Breastfeeding are needed in these sites to improve breastfeeding initiation, to reinforce exclusive breastfeeding and delay introduction of non-breast milk foods and/or liquids. PMID:26825923

  14. Comparison of measles complications in well nourished and mal-nourished children

    International Nuclear Information System (INIS)

    Measles is the most common and the most infectious of the viral infections of childhood. It can cause severe pneumonia, diarrhoea, encephalitis, and death. A significant proportion of deaths due to measles in young children worldwide are attributable to low weight for age. To compare the measles complications in well-nourished and mal-nourished children, this cross-sectional study was conducted at Paediatric out-patient department and paediatric unit 1 Bahawal Victoria Hospital Bahawalpur. Total 120 patients were included in the study. All patients presented with signs and symptoms suggestive of measles according to WHO criteria. These patients were divided into well nourished and malnourished according to the modified Gomez classification. Both groups were evaluated for measles complications like pneumonia, diarrhoea, encephalitis, corneal ulceration, thrombocytopenia, otitis media and myocarditis by detailed history and complete physical examination, and statistically analysed. In the studied patients, 75 were males and 45 were females. Mean age was 23 months. Fifty-nine (49.2%) patients were well-nourished and 61 (50.8%) were undernourished. Fifty-two (43.3%) patients were having pneumonia. Fifty-three (44.2%) patients were having diarrhoea. Twenty-six (21.7%) patients were having encephalitis. Corneal ulceration was found in 9 (7.5%) patients. Thrombocytopenia and otitis media was present in 1 patient in each group. Fourteen patients expired. Measles is a global epidemic problem having many serious complications, including pneumonia, diarrhoea, encephalitis, corneal ulcerations etc. Moreover these complications are more frequent in under nourished children. Efforts should be made to improve the nutritional status of the children and to eradicate this disease by effective vaccination. (author)

  15. Comprometimento pulmonar na malária (revisão Pulmonary involvement in malaria

    Directory of Open Access Journals (Sweden)

    Marcos Boulos

    1993-02-01

    Full Text Available Com uma incidência de 3 a 10% dos casos e letalidade próxima a 70%, o comprometimento pulmonar constitui uma das manifestações mais graves da malária por Plasmodium falciparum. Embora sua patogênese não esteja perfeitamente esclarecida, reconhece-se que a hiperativação do sistema imune por antígenos liberados pelo Plasmodium falciparum desempenhe um importante papel no desencadeamento e agravamento das lesões. A estrutura alvo parece ser o endotélio capilar, responsável pelo fluxo de líquidos para o espaço intersticial. Essas células são ativadas por ação de citocinas, produzidas por linfócitos e macrófagos durante a resposta imune, e passam a expressar em sua membrana celular receptores e moléculas de aderência que facilitam a sequestração de eritrócitos parasitados e também a aderência de células capazes de produzir mediadores inflamatórios. A reação inflamatória e a lesão endotelial que se seguem, juntamente com as alterações hemodinâmicas induzidas pelo bloqueio capilar devido ao acúmulo local de eritrócitos e células inflamatórias causam alterações de permeabilidade vascular e, consequentemente, acúmulo de líquido nos espaços intersticiais e alvéolos. Nos casos mais graves, as manifestações clínicas assemelham-se às do quadro da Síndrome do desconforto respiratório do adulto. Comprometimento pulmonar grave pode se instalar rapidamente em qualquer estágio da evolução clínica da malária, mesmo após a cura parasitológica, desconhecendo-se os fatores desencadeantes. Hiperparasitismo, insuficiência renal e gravidez constituem fatores predisponentes. O prognóstico dependerá da rapidez com que o diagnóstico for estabelecido e o correto tratamento instituído. Além do tratamento instituído contra o parasita, especial atenção deverá ser dispensada à monitorização hemodinâmica, se possível através de cateter de Swan-Ganz, à manutenção de adequada oxigenação e balanço h

  16. Manobras para o tratamento da vertigem posicional paroxística benigna: revisão sistemática da literatura Maneuvers for the treatment of benign positional paroxysmal vertigo: a systematic review

    Directory of Open Access Journals (Sweden)

    Lázaro Juliano Teixeira

    2006-02-01

    Full Text Available A Vertigem Posicional Paroxística Benigna (VPPB é uma das mais freqüentes patologias do sistema vestibular e é caracterizada por episódios de vertigens recorrentes desencadeados por movimentos da cabeça ou mudanças posturais. Há várias opções para o seu tratamento, porém as efetividades terapêuticas das mesmas permanecem controversas. OBJETIVO: Avaliar a efetividade terapêutica das manobras específicas disponíveis para o tratamento da VPPB. METODOLOGIA: Realizou-se uma busca eletrônica nas principais bases de dados, selecionando-se estudos clínicos randomizados envolvendo adultos com diagnóstico de VPPB confirmado com o teste de Dix-Hallpike e tratamento com manobras específicas (Epley ou Semont, por exemplo. Considerou-se como desfecho clínico a negativação do teste de Dix-Hallpike e a melhora das queixas subjetivas. Agruparam-se em metanálise os estudos com Escala de Jadad igual ou superior a três. RESULTADOS: Cinco estudos clínicos preencheram os critérios de inclusão, ou seja, ensaios randomizados de fase I comparando a manobra de Epley com placebos e controles. A metanálise mostra evidência dos efeitos benéficos da manobra de Epley para o tratamento do canal semicircular posterior (magnitude do efeito de 0,11 [IC 95% 0.05, 0.26] de melhora objetiva (Dix-Halpike após uma semana, 0.24 [IC 95% 0.13, 0.45] após um mês e 0.16 [IC 95% 0.08, 0.33] de melhora referida pelos pacientes após a primeira semana. CONCLUSÃO: Evidencia-se boa eficácia clínica da manobra de Epley para o tratamento da VPPB do canal semicircular posterior. Contrariamente, trabalhos com a manobra de Semont e as propostas de manejo dos demais canais semicirculares não obtiveram qualidade metodológica satisfatória, não sendo possível demonstrar a efetividade dos mesmos.Benign Paroxysmal Positional Vertigo (BPPV is one of the most frequent diseases of the vestibular system and it is characterized by episodes of recurrent vertigo

  17. Embolización selectiva de la arteria carótida externa en el manejo de pacientes con tumoraciones benignas en la cavidad nasal y la cara, primeras experiencias en el Hospital México

    Directory of Open Access Journals (Sweden)

    José Luis Solano- Villarroel

    2007-01-01

    Full Text Available Justificación: El angiofibroma juvenil nasofaríngeo es uno de los tumores benignos de la cavidad nasal más comunes en los adolescentes, el cual causa epistaxis recurrente, obstrucción nasal, rinorrea y otras manifestaciones clínicas. Los hemangiomas faciales son tumoraciones benignas muy frecuentes en la infancia, y secundariamente al tumor los pacientes pueden presentar deformidades faciales e inclusive sangrados intermitentes. En la actualidad, la embolización de la arteria carótida externa está siendo más utilizada en el manejo de estos pacientes, ya que es un procedimiento mínimamente invasivo y produce una evolución clínica más favorable en los pacientes; también se ha descrito una menor pérdida sanguínea durante el procedimiento quirúrgico y en el postoperatorio, con disminución de la mortalidad. Además, proporciona al paciente una recuperación más pronta y acorta la estancia hospitalaria. Objetivo: Describir las primeras experiencias con la embolización de la arteria carótida externa en pacientes con angiofibroma juvenil nasofaringeo y hemangiomas faciales, en el Hospital México. Resultados: Cuando se hizo la embolización prequirúrgica de los angiofibromas juveniles nasofaringeos, la resección del tumor en pacientes cursó sin ninguna complicación. Además, los pacientes no tuvieron sangrado durante el postoperatorio inmediato. Tras la embolización de las pacientes con hemangiomas se documenta mejoría clínica, disminuyendo la lesión macroscópica en la cara y los sangrados secundarios al hemangioma (en un caso. En ambas enfermedades la recuperación de los pacientes fue muy satisfactoria, sin presentarse ninguna complicación y con una estancia hospitalaria muy corta. Conclusión: Desde hace varios años la embolización prequirúrgica ha sido utilizada en el extranjero como coadyuvante en el manejo de diversas condiciones. Actualmente, está siendo implementada en el medio para el manejo de diferentes

  18. Hiperglicemia materna diária diagnosticada pelo perfil glicêmico: um problema de saúde pública materno e perinatal Maternal daily hyperglycemia diagnosed by glycemic profile: a maternal and perinatal public health problem

    Directory of Open Access Journals (Sweden)

    Marilza Vieira Cunha Rudge

    2005-11-01

    Full Text Available Este trabalho constitui uma síntese e revisão dos principais resultados das pesquisas, com o objetivo de validar o grupo IB de Rudge. As gestantes deste grupo têm rastreamento positivo e diagnóstico negativo para o diabete gestacional, ou seja, apresentam resposta normal ao teste oral de tolerância à glicose (TTG100g. Apesar disso, as alterações nas glicemias ao longo do dia, confirmadas no perfil glicêmico (PG caracterizam a hiperglicemia diária, fator responsável por risco materno e desfecho perinatal adverso. Estas gestantes são erroneamente incluídas na categoria de "pré-natal de baixo risco" e não estão sendo diagnosticadas e tratadas. Correspondem a 13,8% da população de gestantes rastreadas que, somados aos 7,0% das gestações complicadas por diabete, aumentam a ocorrência de distúrbios hiperglicêmicos na gestação para cerca de 20,0%. Tem índice de mortalidade perinatal de 41‰, semelhante ao de gestantes diabéticas e 10 vezes maior que o de não diabéticas; suas placentas apresentam alterações morfológicas e funcionais diferenciadas dos grupos de gestantes não diabéticas e diabéticas, indicativas de ajuste para manutenção da atividade funcional, facilitando a passagem de glicose para o feto e explicando a macrossomia fetal (53,8% das gestantes não tratadas. O risco materno para hipertensão, obesidade e hiperglicemia é elevado e parece reproduzir modelo da síndrome metabólica, favorecendo risco potencial para diabete no futuro; 10 anos após a gravidez-índice, o diabete clínico tipo 2 foi confirmado em 16,7% das mulheres do grupo IB. Os autores propõem o desenvolvimento de projetos multicêntricos, para identificar biomarcadores, de múltiplos enfoques, específicos das gestantes do grupo IB de Rudge e estabelecer protocolos para o diagnóstico dos distúrbios hiperglicêmicos da gestação, padronizando a associação TTG100g + PG, conduta que poderá causar impacto na morbimortalidade

  19. Detection and characterization of nanoparticles by field flow fractionation (FFF) using multiangle light scattering (MALS) and ICPMS

    International Nuclear Information System (INIS)

    Full text: Exposure to engineered nanoparticles (ENPs) via food may lead to adverse health effects in humans. Metrics relevant for evaluation of toxicity of ENPs include their size distribution, agglomeration state, solubility and elemental composition. A FFF was used to size separate clays, silver, gold, selenium and GdatC82OH16 ENPs. Their radii were determined on-line by MALS and their elemental profile by ICPMS. These methods were applied for quality assurance of the long-term stability of suspensions of Ag and Se. A multitude of detection techniques, including electron microscopic imaging, are needed for future studies of ENPs in biological materials. (author)

  20. Malária pulmonar: aspectos na tomografia computadorizada de alta resolução - relato de caso

    Directory of Open Access Journals (Sweden)

    Rodrigues Rosana

    2004-01-01

    Full Text Available Neste trabalho é relatado o caso de paciente do sexo masculino, de 38 anos de idade, que desenvolveu quadro de malária com comprometimento pulmonar. A tomografia computadorizada de alta resolução evidenciou espessamento de septos interlobulares e de bainhas peribroncovasculares, com áreas esparsas de atenuação em vidro fosco e de consolidações, além de derrame pleural bilateral, aspectos compatíveis com edema pulmonar. O paciente recebeu tratamento específico, evoluindo bem e tendo alta 11 dias após a internação.

  1. Malária pulmonar: aspectos na tomografia computadorizada de alta resolução - relato de caso

    OpenAIRE

    Rodrigues Rosana; Marchiori Edson; Souza Daniel Andrade Tinoco de

    2004-01-01

    Neste trabalho é relatado o caso de paciente do sexo masculino, de 38 anos de idade, que desenvolveu quadro de malária com comprometimento pulmonar. A tomografia computadorizada de alta resolução evidenciou espessamento de septos interlobulares e de bainhas peribroncovasculares, com áreas esparsas de atenuação em vidro fosco e de consolidações, além de derrame pleural bilateral, aspectos compatíveis com edema pulmonar. O paciente recebeu tratamento específico, evoluindo bem e tendo alta 11 di...

  2. Využití modelu SWIM pro simulace evapotranspirace v povodí Malše

    Czech Academy of Sciences Publication Activity Database

    Košková, Romana; Němečková, Soňa

    Praha : Ústav pro hydrodynamiku AV ČR, v.v , 2008 - (Šír, M.; Tesař, M.; Lichner, L.), s. 147-154 ISBN 978-80-87117-03-3. [Hydrologie malého povodí 2008. Praha (CZ), 23.04.2008-24.04.2008] R&D Projects: GA AV ČR(CZ) KJB300600602 Institutional research plan: CEZ:AV0Z20600510 Keywords : hydrological model ling * SWIM * actual evapotranspiration Subject RIV: DA - Hydrology ; Limnology

  3. Epitope grafting, re-creating a conformational Bet v 1 antibody epitope on the surface of the homologous apple allergen Mal d 1

    DEFF Research Database (Denmark)

    Holm, Jens; Ferreras, Mercedes; Ipsen, Henrik; Würtzen, Peter A; Gajhede, Michael; Larsen, Jørgen N; Lund, Kaare; Spangfort, Michael D

    2011-01-01

    Birch-allergic patients often experience oral allergy syndrome upon ingestion of vegetables and fruits, most prominently apple, that is caused by antibody cross-reactivity of the IgE antibodies in patients to proteins sharing molecular surface structures with the major birch pollen group 1 allergen...... from Betula verrucosa (Bet v 1). Still, to what extent two molecular surfaces need to be similar for clinically relevant antibody cross-reactivity to occur is unknown. Here, we describe the grafting of a defined conformational antibody epitope from Bet v 1 onto the surface of the homologous apple...... allergen Malus domestica group 1 (Mal d 1). Engineering of the epitope was accomplished by genetic engineering substituting amino acid residues in Mal d 1 differing between Bet v 1 and Mal d 1 within the epitope defined by the mAb BV16. The kinetic parameters characterizing the antibody binding interaction...

  4. Development of hypo-allergenic apples: silencing of the major allergen Mal d 1 gene in "Elstar" apple and the effect of grafting

    DEFF Research Database (Denmark)

    Krath, Britta; Eriksen, Folmer Damsted; Pedersen, Bjarne H.; Gilissen, Luud J.W.J; Van de Weg, W. Eric; Dragsted, Lars Ove

    Mal d 1 mRNA were produced by RNA interference (RNAi) technology. Ten genetically modified (GM) apple lines were selected. In vitro plantlets were first transferred to a greenhouse, then grafted onto wild-type M.9 rootstock to promote the development of fruit-producing trees. Levels of Mal d 7 gene...... silencing were measured repeatedly by quantitative real-time PCR. Compared to leaf samples from wild-type 'Elstar', two GM lines showed modest levels of gene silencing (up to 250-fold), whereas the other eight GM lines were significantly silenced (up to 10,000-fold) in Mal d 1 gene expression. These levels...... of silencing were unaffected by grafting, and have been stable over more than 3 years, and throughout all developmental stages....

  5. Epidemiologia da malária em Cabo Verde - Factores genéticos humanos e estrutura populacional do mosquito vector

    OpenAIRE

    Alves, Joana Baptista

    2010-01-01

    A malária, doença parasitária complexa que resulta da interacção entre parasita, hospedeiros humano e vector, constitui um dos principais problemas de saúde a nível mundial. À semelhança de outras doenças parasitárias e infecciosas a malária tem um papel importante na evolução, tendo já sido demonstrado o papel da variação genética humana na resistência à infecção. Após quase meio século de controlo, a malária persiste na ilha de Santiago onde, apesar da baixa endemicidade, os indivíduos a...

  6. Silêncio - crítica - aprendizado: uma análise teológica introdutória ao tema do mal

    Directory of Open Access Journals (Sweden)

    Claudio de Oliveira Ribeiro

    2011-12-01

    Full Text Available RESUMOO texto apresenta implicações para o tema do mal oriundas do encontro da teologia com o pensamento moderno, tanto o que se consolidou no final do século 19, fortemente marcado pelo racionalismo e pelo iluminismo, como o que resultou das críticas vindas das filosofias da existência já nas primeiras décadas do século 20. Trata também da relação entre o mal e o pecado e do mal e do sofrimento como fragilidades originais do ser humano. A referência interpretativa é a de evitar as visões de uma “teologia da retribuição”, meritória, capaz de em seu extremo gerar a ideia de um deus cruel. O mal é visto, sobretudo, por aquilo que prejudica ou fere a vida e a felicidade do humano e do mundo. Como decorrência da vocação prática da teologia, são indicadas posturas consideradas adequadas frente ao mal. Palavras-chave: Mal; pecado; teologia contemporânea; antropologia.ABSTRACTThe paper presents implications for the issue of evil arising from the encounter of theology with modern thought, which were consolidated both, in the late nineteenth century, strongly influenced by rationalism and the Enlightenment, and the first decades of the twentieth century, by the criticism of existentialist philosophy. It also addresses the relationship between evil and sin and evil and suffering as a unique human frailty. The interpretive reference is to avoid the visions of a “theology of retribution,” worthy, capable of generating at its extreme the idea of a cruel god. Evil is seen above all by what harms or injures life and happiness of the human and the world. As a result of the practical nature of theology, are indicated attitudes considered appropriate against the evil.Keywords: Evil; sin; contemporary theology; anthropology.RESUMENEl texto presenta implicaciones para el tema del mal provenientes del encuentro de la teología con el pensamiento moderno, tanto el que se consolidó hacia finales del siglo XIX, fuertemente marcado por

  7. Tuberculose ostéoarticulaire (mal de Pott exclu): à propos de 120 cas à Abidjan

    Science.gov (United States)

    Gbané-Koné, Mariam; Koné, Samba; Ouali, Boubacar; Djaha, Kouassi Jean -Mermoz; Akoli, Ekoya Ondzala; Nseng, Ingrid Nseng; Eti, Edmond; Daboiko, Jean Claude; Touré, Stanislas André; Kouakou, N'zué Marcel

    2015-01-01

    Introduction La tuberculose ostéoarticulaire (TOA) représente 2 à 5% de l'ensemble des tuberculoses. Elle demeure d'actualité surtout dans les pays à forte endémicité tuberculeuse. L'objectif était de déterminer la prévalence, les aspects topographiques, radiologiques de la TOA en milieu hospitalier ivoirien. Méthodes Les auteurs rapportent une expérience de 11 ans, à travers une étude rétrospective de 120 dossiers de patients atteints de la tuberculose ostéoarticulaire (le mal de Pott est exclu de cette étude). N'ont pas été inclus dans l’étude les dossiers ne comportant pas d'imagerie. Résultats L'atteinte extra vertébrale représentait 09,2% de la tuberculose ostéoarticulaire. Il s'agissait de 54 hommes et 66 femmes, l’âge moyen était de 43,13 ans. On notait 123 cas d'ostéoarthrites, et 8 cas d'ostéites des os plats. L'atteinte des membres inférieurs prédominait dans 91,87% des cas. La hanche était la première localisation (45,04%), suivie du genou (25,19%). Les atteintes étaient multifocales dans 20% des cas. L'atteinte osseuse était associée à une tuberculose pulmonaire dans 05,83% des cas. Des localisations inhabituelles ont été rapportées: poignet (n = 2), branches ischiopubiennes (n = 4), atteinte sternoclaviculaire (n = 4), médiopieds (n = 2). Les lésions radiologiques étaient avancées (stades III et IV) dans 55,73% des cas. A la TDM, la prévalence des abcès était de 77%. Un geste chirurgical a été réalisé sur 16 articulations (2 épaules, 13 genoux, une cheville). Conclusion La TOA des membres est peu fréquente contrairement à l'atteinte vertébrale. La hanche est la principale localisation. Le retard au diagnostic explique l’étendue des lésions anatomoradiologiques. PMID:26587129

  8. Narrativité et la question du mal dans la Bible

    Directory of Open Access Journals (Sweden)

    Maria da Penha Villela-Petit

    2015-04-01

    Full Text Available Il est fréquent de lire que les parties narratives de la Bible encadrent les parties législatives (et surtout les commandements. Bien que l’on reconnaisse aussitôt que la Bible, à commencer par le Pentateuque (la Torah, recèle un enseignement diversifié ayant pour but d’éclairer et rectifier nos chemins de vie, de telle sorte que nous puissions répondre à l’appel que Dieu nous fait de devenir ses  «enfants», le fait de prendre les parties narratives pour un encadrement n’est pas sans ambiguïté.  Dans cette brève communication, nous voulons mettre en relief le caractère central et incontournable des histoires racontées, à commencer par celles de la Genèse. Pour que l’enseignement biblique soit effectif dans nos vies, la dimension législative des commandements est insuffisante. Les interdictions elles-mêmes ne deviennent signifiantes que parce qu’elles s’opposent à ce qui arrive d’égarement et de cécité dans l’histoire de nos vies. Ce sont les récits qui nous instruisent sur ces égarements en nous rendant plus conscients sur nos manières de vivre. Leur rôle est de convertir notre regard et sur notre vie personnelle et sur notre  «monde de vie» dans ses divers aspects (sociaux, politiques, religieux.  A cette fin, nous concentrerons donc notre attention sur le récits où ce qui est en jeu ce sont les manifestations du mal. Après avoir évoqué l’histoire d’Adam et Eve, c’est-à-dire le récit mythique de la façon dont le premier couple s’est laissé tromper et illusionner par Satan, nous aborderons d’autres récits (y compris celui du Livre de  Job en vue d’analyser quelques-unes de leurs leçons.

  9. Estudio observacional prospectivo con insulina detemir en pacientes con diabetes mellitus tipo 2 mal controlados que inician por primer vez tratamiento con insulina (estudio SOLVE)

    OpenAIRE

    Domingo Orozco-Beltrán; Sara Artola-Menéndez

    2016-01-01

    Objetivo: Describir la experiencia en atención primaria con insulina detemir en pacientes con diabetes mellitus tipo 2 mal controlados con antidiabéticos orales que necesitan incorporar una insulina a su terapia antidiabética. Métodos: Estudio observacional prospectivo de 6 meses de seguimiento realizado en 10 países. En España participaron solo centros de atención primaria. Se reclutaron pacientes con diabetes mellitus tipo 2 mal controlados a cuyo tratamiento con antidiabéticos orales se...

  10. La cromatografía de gases y la espectometría de masas: identificación de compuestos causantes de mal olor

    OpenAIRE

    Gutiérrez Bouzán, Mª Carmen; Droguet, Marta

    2002-01-01

    Se describe la cromatografía de gases y su acoplamiento con la espectrometría de masas, técnicas que constituyen una herramienta potente para separar, identificar y cuantificar los componentes volátiles y semivolátiles de mezclas complejas. Se aplican estas técnicas a la identificación de los compuestos que producen mal olor en un tejido. Para ello, se emplea también la extracción de espacio en cabeza. De los resultados del análisis GC-MS se desprende que la principal causa del mal olor e...

  11. Fingerpainting am Touchscreen. Fünf Mal- und Zeichen-Apps für Android-Tablets

    Directory of Open Access Journals (Sweden)

    Christoph Kaindel

    2015-06-01

    Full Text Available Malen auf dem Touchscreen eines Smartphones oder Tablets ist eine natürliche und intuitive Tätigkeit; anders als bei der Nutzung eines Grafiktabletts am PC gibt es so gut wie keine Umstellungsphase. Christoph Kaindel hat für uns fünf Mal- und Zeichen-Apps unter die Lupe genommen. Bereits für Kinder ist in den diversen Appstores eine große Zahl an einfachen Mal-Apps zu finden, mit meist nur wenigen Einstellungsmöglichkeiten und oft fragwürdiger Qualität. Am anderen Ende des Spektrums liegt der professionelle Einsatz von Tablets im Grafikbereich, für den spezialisierte und entsprechend teure Geräte notwendig sind. Ich werde einige Apps aus dem Mittelfeld vorstellen, die sich für einfache wie anspruchsvolle Vorhaben und Projekte eignen, auch auf schwächeren Tablets laufen und preisgünstig oder gratis sind. Alle Apps bieten die Möglichkeit, unterwegs zu malen, zu skizzieren, Fotos zu verfremden und die entstandenen Bilder am PC weiter bearbeiten zu können. Für PCs gibt es einige empfehlenswerte kostenlose Malprogramme, die ich bereits in einem anderen Artikel (http://medienimpulse.at/articles/view/616 vorgestellt habe.

  12. The half-lives of sup(26m)Al, 34Cl, sup(38m)K

    International Nuclear Information System (INIS)

    The half-lives of sup(26m)Al, 34Cl and sup(38m)K have been measured with isotopically pure samples prepared with an on-line isotope separator. Emitted #betta#+ particles were observed with a large-solid-angle, high-efficiency, low-background gas proportional counter, from which signals were multiscaled. The counting electronics had a well-defined non-extendable dead time. Each sample decay curve was individually corrected for dead time before being summed with other accumulated data, no pile-up corrections being necessary. The analysis procedure was tested on hypothetical data. The effect of contaminant isobars on the resultant half-lives has been investigated. Our half-life results are sup(26m)Al: 6346.2 +- 2.6 ms, 34Cl: 1527.7 +- 2.2 ms and sup(38m)K: 924.2 +- 0.3 ms. The quoted uncertainties include - for the first time - explicit provision for all possible contaminants. (orig.)

  13. Crystal Structure and Interaction with DNA of [Ni(phen)(mal)(H2O)2]·3H2O

    Institute of Scientific and Technical Information of China (English)

    GAO En-Jun; CHEN Mao-Sheng; YU Ying; SUN Ya-Guang

    2007-01-01

    A new complex [Ni(phen)(mal)(H2O)2]·3H2O (phen = 1,10-phenanthroline,mal2-= malonic acid) has been synthesized by the reaction of nickel nitrate,phen and malonic acid.EA,IR spectra and X-ray single-crystal diffraction were carried out to determine the composition and crystal structure of the title complex.Crystal data:monoclinic system,space group P2/c,a =8.937(3),b = 12.163(5),c = 9.725(3)(A),β = 119.36°,C15H19N2O9Ni,Mr= 430.03,Z = 2,F(000) =446,V = 921.3 (A)3,Dc = 1.550 g/cm3,μ = 1.104 mm-1,-10≤h≤ 10,-12≤k≤ 14,-11 ≤l≤7,R =0.0261 and wR = 0.0609 for 4376 (Rint = 0.0203) independent reflections and 1631 observed ones (I> 2σ(I)).Ni(Ⅱ) exhibits an octahedral coordination geometry,with hydrogen bonds and π-π interactions stabilizing the whole structure.UV spectrum of the complex interacting with protamine DNA indicates that the title compound interacts with DNA via insertion mode with bonding constant Kb of 1.11 × 104.

  14. Critérios histopatológicos para diagnóstico de melanoma maligno cutâneo: análise comparativa de sua freqüência em lesões benignas e melanomas de pequena espessura (< 2 mm Histopathological criteria for cutaneous malignant melanoma: comparative analysis between benign and thin malignant lesions (< 2 mm

    Directory of Open Access Journals (Sweden)

    Luiz Alberto Veronese

    2007-10-01

    Full Text Available INTRODUÇÃO: A histopatologia convencional continua sendo o padrão-ouro no diagnóstico dos melanomas cutâneos, apesar do progresso da imuno-histoquímica e da biologia molecular. Os critérios microscópicos existentes para esse diagnóstico são numerosos, porém nenhum deles é específico para se afirmar que uma determinada lesão é maligna quando ele está presente, ou é benigna na sua ausência. Alguns critérios têm uma relevância maior para o diagnóstico em relação a outros. OBJETIVO: Este estudo propõe uma análise daqueles critérios considerados mais importantes, comparando sua presença em lesões melanocíticas benignas e melanomas. MATERIAL E MÉTODOS: Foram estudadas 33 lesões melanocíticas benignas (nevo de Spitz: 13; nevo de Reed: 6; nevo displásico: 6; nevo congênito: 3; nevo adquirido: 3; nevo combinado: 1; nevo recorrente: 1, bem como 101 casos de melanomas extensivo/superficiais: 25 intra-epidérmicos e 76 invasivos de pequena espessura (INTRODUCTION: Conventional histopathology has been considered as the gold standard in the diagnosis of cutaneous malignant melanoma, despite the progress of molecular biology and immunohistochemistry. There are many microscopic criteria for diagnosis of melanoma, however there is not a single one that can be useful to define malignancy. AIM: Our purpose is to analyse the criteria considered more important to the diagnosis of melanoma, comparing their presence in benign melanocytic lesions and melanomas. MATERIAL AND METHODS: We studied 33 benign melanocytic lesions (Spitz nevi, 13; Reed nevi, 6; dysplastic nevi, 6; congenital nevi, 3; acquired nevi, 3; combined nevus, 1; recurrent nevus, 1 and 101 extensive/superficial melanomas (25 in situ and 76 invasive up to 2 mm thickness. RESULTS: Some criteria showed high frequency in benign lesions, showing low-specificity, while others had low-positivity in the benign and high-frequency in malignant lesions, consequently high

  15. Mal-β-CD对黑胡椒精油的包合作用研究%Research on inclusion properties of maltosyl-β-cyclodextrin by forming complexes essential oil from piper nigrum

    Institute of Scientific and Technical Information of China (English)

    王冠群; 曲静然; 丁烽; 崔波; 檀琮萍

    2012-01-01

    Studied the inclusion interaction between Mal-β-CD and β-caryophyllene. Mole ratios of Mal-β-CD and β-caryophyllene, inclusion temperature, inclusion time as variables, inclusion rate of as index, technology parameters of inclusion reaction were optimized by orthogonal experiments. The inclusion compound was identified by infrared(IR) spectrometry, thermogravimetric (TG). The result showed that the optimal conditions for the inclusion compound were as follows: The result showed that the optimal conditions for the inclusion compound were as follows: inclusion temperature 70 "C , inclusion time 90 min, mole ratios of Mal-β-CD and βcaryophyllene 1 : 1. The inclusion of Mal-β-CD with oil from piper nigrum showed high stability, good solublity, the critical humidity of the inclusion was about 67%.%研究Mal-β-CD对黑胡椒精油的包合作用.以包埋率为指标,以包合温度、包合时间和Mal-β-CD和β-石竹烯的摩尔比为变量,通过正交试验确定最佳包合反应工艺参数是包合温度70℃,包合时间90 min,Mal-β-CD和β-石竹烯的摩尔比为1∶1;通过红外扫描和热重分析,确认Mal-β-CD-β-石竹烯包合物的形成,热重分析表明β-石竹烯经Mal-β-CD包埋后,耐热性显著提高;Mal-β-CD包合黑胡椒精油的包合产物稳定性较好,水溶性好,包合物的临界湿度为67%.

  16. Estudo exploratório da utilização de saw palmetto no tratamento da hiperplasia benigna da próstata por urologistas de Porto Alegre Investigation study concerning the saw palmetto use for the benign prostatic hyperplasia treatment by urologists in Porto Alegre

    Directory of Open Access Journals (Sweden)

    Gabriela Ferreira

    2008-06-01

    Full Text Available O objetivo deste trabalho foi avaliar a utilização de fitoterápicos a base de saw palmetto na terapia sintomática da hiperplasia benigna da próstata (HBP por médicos urologistas da cidade de Porto Alegre. Consistiu em um estudo transversal, exploratório, por meio de entrevista semi-estruturada aplicada a urologistas de Porto Alegre. A amostra foi obtida utilizando catálogo do plano de saúde UNIMED- Porto Alegre. A randomização foi realizada através de sistemática aleatória, sendo sorteados trinta e cinco médicos, dos quais 21 foram selecionados para realização da pesquisa através de questionário. Todos os urologistas entrevistados avaliam e tratam pacientes com hiperplasia benigna da próstata. O saw palmetto não foi citado como terapia medicamentosa de 1ª ou 2ª escolhas no tratamento da HBP. O grupo farmacológico mais freqüentemente utilizado para o tratamento da HBP foi ∝-bloqueadores. Mais da metade dos médicos entrevistados relata ter conhecimento sobre a utilização do saw palmetto, principalmente através de artigos científicos. Os resultados indicam que o saw palmetto não é prescrito pelos urologistas em Porto Alegre, todavia a maior parte destes profissionais tem conhecimento sobre sua utilização.The aim of this work was to assess the prescription of saw palmetto phytomedicines for improving symptoms of benign prostatic hyperplasia (BPH by urologists in Porto Alegre (Brazil. The study was transversal and exploratory consisting of a semi-structured interview with urologists. The sample was obtained from the UNIMED Catalog - Porto Alegre (Brazil. The randomization was made by chance, being selected thirty-five physicians. The first twenty-one who accepted to participate were interviewed. All the interviewed urologists treat patients with benign prostatic hyperplasia. The saw palmetto was not mentioned as the first or second choice for treating BPH. The α-blockers were the most mentioned pharmacological

  17. Mal tiempo, tiempo maligno, tiempo de subversión ritual. La temposensitividad agrofestiva invernal

    Directory of Open Access Journals (Sweden)

    Del Campo Tejedor, Alberto

    2006-06-01

    ícolas y expresivo (rituales y fiestas; y, finalmente, un tiempo bipolar, que se experimenta desde antiguo en dos estaciones —invierno y verano—, base de una temposensitividad agrofestiva igualmente dicotómica, que es analizada a raíz de la siguiente hipótesis: durante los meses de buen tiempo, especialmente mayo y junio, los rituales de nuestro entorno funcionan con un sentido propiciatorio y de exaltación positiva, escenificando miméticamente la unión entre tierra, vegetación, animal y hombre a través de prototipos o arquetipos que recrean simbólicamente el orden natural de las cosas. Por el contrario, las fiestas y rituales invernales —desde Todos los Santos hasta el Carnaval, y muy especialmente los días en torno a la Navidad— tienen en común su carácter grotesco y de inversión del orden, que expresa en clave simbólica, con una lógica jocoseria y ambigua, el lado oscuro de la existencia, conjurando ritualmente los miedos al mal tiempo, al tiempo aciago y nefasto, al tiempo del frío, la noche, el hambre y la muerte.

  18. Eletrodo de marca-passo mal posicionado no ventrículo esquerdo Electrodo de marcapasos mal posicionado en el ventrículo izquierdo Pacemaker electrode misplaced in the left ventricle

    Directory of Open Access Journals (Sweden)

    André Luiz Cerqueira de Almeida

    2010-09-01

    Full Text Available Relatamos caso de implantação anômala de eletrodo de marca-passo VVI no ventrículo esquerdo (VE, diagnosticada durante avaliação de rotina, dois anos pós-implante. Trata-se de mulher de 65 anos e soropositiva para doença de Chagas. O eletrocardiograma (ECG apresentava padrão de bloqueio do ramo direito. A radiografia de tórax em perfil mostrou trajeto com curvatura posterior do eletrodo. No ecocardiograma transtorácico, o diagnóstico final mostrou cateter que penetrava o átrio direito, atravessava o septo interatrial e descia pelo átrio esquerdo e orifício valvar mitral para se implantar na parede lateral do VE. Abordam-se os seguintes aspectos relacionados: possíveis trajetos de implantação, quadro clínico, radiológico, eletrocardiográfico, ecocardiográfico, complicações e opções terapêuticas.Relatamos caso de implantación anómala de electrodo de marcapasos VVI en el ventrículo izquierdo (VI, diagnosticada durante evaluación de rutina, dos años post implante. Se trata de mujer de 65 años y seropositiva para enfermedad de Chagas. El electrocardiograma (ECG presentaba estándar de bloqueo de rama derecha. La radiografía de tórax de perfil mostró trayecto con curvatura posterior del electrodo. En el ecocardiograma transtorácico, el diagnóstico final mostró catéter que penetraba el atrio derecho, atravesaba el septo interatrial y descendía por el atrio izquierdo y orificio valvar mitral para implantarse en la pared lateral del VI. Se abordan los siguientes aspectos relacionados: posibles trayectos de implantación, cuadro clínico, radiológico, electrocardiográfico, ecocardiográfico, complicaciones y opciones terapéuticas.This study reports the case of an anomalous implantation of VVI pacemaker electrode in the left ventricle (LV diagnosed during routine evaluation, two years after implantation. The patient is a 65-year-old woman with Chagas disease. Electrocardiogram (ECG revealed a pattern of right

  19. First successful reduction of clinical allergenicity of food by genetic modification: Mal d 1-silenced apples cause fewer allergy symptoms than the wild-type cultivar

    DEFF Research Database (Denmark)

    Dubois, A. E. J.; Pagliarani, G.; Brouwer, R. M.;

    2015-01-01

    BACKGROUND: Genetic modification of allergenic foods such as apple has the potential to reduce their clinical allergenicity, but this has never been studied by oral challenges in allergic individuals. METHODS: We performed oral food challenges in 21 apple-allergic individuals with Elstar apples...... which had undergone gene silencing of the major allergen of apple, Mal d 1, by RNA interference. Downregulation of Mal d 1 gene expression in the apples was verified by qRT-PCR. Clinical responses to the genetically modified apples were compared to those seen with the wild-type Elstar using a visual...... analogue scale (VAS). RESULTS: Gene silencing produced two genetically modified apple lines expressing Mal d 1.02 and other Mal d 1 gene mRNA levels which were extensively downregulated, that is only 0.1-16.4% (e-DR1) and 0.2-9.9% (e-DR2) of those of the wild-type Elstar, respectively. Challenges with...

  20. The half lives of sup(26m)Al, 34Cl, sup(38m)K: Precision measurements with isotope-separated samples

    International Nuclear Information System (INIS)

    The half-lives of sup(26m)Al, 34Cl and sup(38m)K have been measured with isotopically pure samples prepared with an on-line isotope separator. The results are 6346.2+-2.6 ms, 1527.7+-2.2 ms and 924.2+-0.3 ms respectively. (orig.)

  1. Sobre o Mal-estar Hoje: Do Cérebro à Pulsão de Morte

    Directory of Open Access Journals (Sweden)

    Barbara Paraiso Garcia Duarte da Rosa

    2013-01-01

    Full Text Available Hace unos años las pruebas formuladas por las neurociencias y la proliferación de categorías psicopatológicas ha colaborado para la legitimación y la multiplicación de los discursos llenos de promesas de curación de sufrimiento psíquico. En este contexto — donde la psicopatología está dirigida de un concepto predominante biológico y la proliferación de categorías diagnósticos Si acompañada por el predominio de un enfoque sindrómico de la enfermedad mental — el énfasis en la terapia biológica opera como la promesa de eliminar el malestar de la vida. Este es un proceso de naturalización de la angustia en que multiplicación de categorías de diagnósticos es proporcional a la diversidad de sufrimiento psíquico que puede ser tratado. Presentamos algunos conceptos forjadas por Freud, como la angustia, la impotencia y la pulsión de muerte, como indicadores de la posibilidad de intervenir en el sufrimiento a través de varias perspectivas de aquellos que prometen la exclusión del mal en la vida psíquico. Si malo es signo de desorden promovido por pulsión que no pudo inscribirse en el aparato psíquico, entonces psicoanálisis incluyen mal en el corazón de su propia vida psíquica. El último solamente si es y gracias a la posibilidad de crear nuevos significados, nuevas formas de satisfacción posible para el impulso vital, insistente por excelencia.

  2. La inclusión social por la vía del cuerpo en mujeres diagnosticadas con anorexia bulimia en la ciudad de Medellín, Colombia = Social inclusion through the body in women with anorexia-bulimia in Medellín, Colombia

    Directory of Open Access Journals (Sweden)

    Marín Cortés, Andrés Felipe

    2010-12-01

    Full Text Available Este informe presenta los hallazgos de la investigación "Narrativas identitarias sobre la vivencia corporal en mujeres diagnosticadas con trastorno de la alimentación" efectuada en Medellín.Objetivo: reconocer cómo el significado atribuido a la vivencia corporal devela la construcción de la identidad en mujeres con trastornos de la alimentación.Metodología: enfoque cualitativo, con diseño de casos múltiples analizados mediante los procedimientos del método fenomenológico-hermenéutico. Se hicieron entrevistas en profundidad y grupos focales. El estudio se ajustó a los principios éticos para la investigación en que participan seres humanos, incluyendo el consentimiento informado de cada una de las participantes.Resultados: 1 la evaluación que estas mujeres hacen de sí mismas está cruzada por la mirada de los otros; 2 existen contextos sociales de aparición que estimulan la anorexia-bulimia; 3 se hallaron tres formas de configuración de la anorexia-bulimia: estético-erótica, estéticoatlética y estético-afectiva; 4 la recuperación no consiste solamente en comer, sino también en permitir que el cuerpo se historice, es decir, que muestre en él las marcas del paso del tiempo.

  3. O puru-puru da Amazônia (Pinta, Carate, Mal del Pinto etc

    Directory of Open Access Journals (Sweden)

    F. Nery Guimarães

    1948-03-01

    Full Text Available 1 "Purú-purú" é uma palavra indígena que quer dizer "pintado" ou "manchado", peculiar à Amazonia Brasileira. Com êsse nome é designada uma dermatose referida entre os selvicolas desde 1774, por Ribeiro Sampaio. Certas tribus, com alta incidência da moléstia passaram a ser cahamadas também "Purú-purús", o mesmo acontecendo com o rio onde habitavam - Rio Purús. 2 A doença existe na bacia do Rio Solimões e seus principais afluentes: Javari, Juruá, Purús, Içá, Japurá, e Negro. Por esses rios, o fóco da dermatose se continua nos países limitrofes com o Brasil: Guianas, Venezuela, Colombia, Perú (Equador e Bolivia. 3 Desde 1890 essa dermatose foi relacionada à pinta (carate ou mal del pinto por P. S. de Magalhães, idéa essa depois defendida por Juliano Moreira, Carlos Chagas, Roquete Pinto, Wappeus, O. da Fonseca Filho, Da Matta, Brumpt e outros, baseados na semelhança clínica e na terapêutica. Recentemente (1945, essa provavel identidade das duas dermatoses, recebeu fundamento sorológico de Biocca (que verificou a positividade das reações de Kline e Kahn em doentes de purú-purú, e, pelo presente trabalho, recebe base clínico-epidemio-anatomo-patológica. 4 Sob o ponto de vista clínico, as lesões cutaneas discromicas da moléstia, são de 3 órdens: a lesões papulo-eritemato-escamosas, isoladas ou não, arredondadas, pruriginosas e de bordos nitidos; b lesões maculo-escamosas, maiores mais pálidas, ás vezes já mostrando alterações pigmentares na parte central; c máculas discromod´rmicas, lisas ou ligeiramente escamosas, com maior ou menor alteração pigmentar, as quais assumem diferentes aspéctos, consequentes à hipo - ou hiperpigmentação, variaveis também com a côr do paciente. As colorações predominantes nas manchas, são o branco, o preto e o vermelho, com tonalidades eminentemente variaveis. Embora raramente, nessas extensas dermodiscromias, observa-se superposição de lesões papulo

  4. Crystallization, data collection and data processing of maltose-binding protein (MalE) from the phytopathogen Xanthomonas axonopodis pv. citri

    International Nuclear Information System (INIS)

    The Xanthomonas axonopodis pv. citri maltose-binding protein MalE has been crystallized at 293 K using the hanging-drop vapour-diffusion method. Maltose-binding protein is the periplasmic component of the ABC transporter responsible for the uptake of maltose/maltodextrins. The Xanthomonas axonopodis pv. citri maltose-binding protein MalE has been crystallized at 293 K using the hanging-drop vapour-diffusion method. The crystal belonged to the primitive hexagonal space group P6122, with unit-cell parameters a = 123.59, b = 123.59, c = 304.20 Å, and contained two molecules in the asymetric unit. It diffracted to 2.24 Å resolution

  5. Labor Market Mal-Adjustment in Chile; Structural Economic Reforms and Friction among Sub-Markets Labor Market Mal-Adjustment in Chile; Structural Economic Reforms and Friction among Sub-Markets

    Directory of Open Access Journals (Sweden)

    Luis A. Riveros

    1986-03-01

    Full Text Available Labor Market Mal-Adjustment in Chile; Structural Economic Reforms and Friction among Sub-Markets This paper discusses the main features of the labor market performance in the Chilean economy during the 1970s. Its purpose is to analyse several explanation for Chile's high unemployment levels on the basis of the stylized facts surrounding labor market behavior. Several interpretations on the heavy unemployment prevailing in Chile have been based on the role played by either the labor demand downfall or the abnormal increase in the labor supply. However, those hypotheses have failed in providing a satisfactory explanation for the lack of adjustment seen in the labor market. In this paper, the available evidence on sectoral shifts of production and employment is analyzed in terms of their implications for the unemployment persistence. Owing to the demands for inter-industry labor reallocation stemming from the change in the productive structure, the role played by the existence of industry·specific human capital is stressed. The results detailed here suggest that the persistence of heavy unemployment can be importantly attached to a series of disruptions in different industries; that these disruptions could not be accomodated smoothly in the short run; and that the market has been responding but only slowly.

  6. Sequential motor task (Luria's Fist-Edge-Palm Test in children with benign focal epilepsy of childhood with centrotemporal spikes Tarefa motora sequencial (Teste de Lúria punho-lado-palma em crianças com epilepsia focal benigna da infância com descarga centrotemporal

    Directory of Open Access Journals (Sweden)

    Carmen Silvia Molleis Galego Miziara

    2013-06-01

    Full Text Available This study evaluated the sequential motor manual actions in children with benign focal epilepsy of childhood with centrotemporal spikes (BECTS and compares the results with matched control group, through the application of Luria's fist-edge-palm test. The children with BECTS underwent interictal single photon emission computed tomography (SPECT and School Performance Test (SPT. Significant difference occurred between the study and control groups for manual motor action through three equal and three different movements. Children with lower school performance had higher error rate in the imitation of hand gestures. Another factor significantly associated with the failure was the abnormality in SPECT. Children with BECTS showed abnormalities in the test that evaluated manual motor programming/planning. This study may suggest that the functional changes related to epileptiform activity in rolandic region interfere with the executive function in children with BECTS.Esse estudo avaliou ações motoras manuais sequenciais em crianças com epilepsia focal benigna da infância com descarga centrotemporal (EBICT e comparou os resultados com o grupo controle pareado, através do teste de Lúria (punho-lado-palma. As crianças com EBICT realizaram single photon emission computed tomography (SPECT interictal e Teste de Desempenho Escolar (TDE. Foram encontradas diferenças significativas entre os dois grupos nas atividades motoras de três movimentos iguais e três movimentos diferentes. As crianças com piores resultados no TDE e com SPECT alterado apresentaram mais erros no teste de imitação manual. Crianças com epilepsia fracassaram nos testes de avaliação motora que envolvem programação/planejamento. Esse estudo sugere que mudanças funcionais relacionadas à atividade epileptiforme na região rolândica interfere com as funções executivas de crianças com EBICT.

  7. Buddha and tiger; Mal Buddha, mal Tiger

    Energy Technology Data Exchange (ETDEWEB)

    Schott, Christina

    2010-02-15

    Thailand is foremost in renewable energy in South East Asia, and the country is planning to extend its capacities in this field. At the same time, the country dreams of atomic energy and also pushes doubtful megascale projects in its neighbouring countries. (orig.)

  8. Krajina jako základ životního prostředí malých měst

    Czech Academy of Sciences Publication Activity Database

    Kirchner, Karel; Lacina, Jan

    Brno : Ústav geoniky AV ČR, 2004 - (Vaishar, A.; Frantál, B.), s. 1-16 [Geografie malých měst. Brno (CZ), 24.06.2004-25.06.2004] R&D Projects: GA AV ČR(CZ) IAA3086301 Institutional research plan: CEZ:AV0Z3086906 Keywords : landscape * small towns * biodiversity Subject RIV: DE - Earth Magnetism, Geodesy, Geography

  9. Vodní hmyz řeky Malše v okolí Českých Budějovic

    Czech Academy of Sciences Publication Activity Database

    Boukal S., David; Klečka, J.; Soldán, Tomáš

    České Budějovice: Jihočeské muzeum, 2006, s. 229-234. ISBN 80-86260-60-7 R&D Projects: GA AV ČR 1QS500070505 Institutional research plan: CEZ:AV0Z50070508 Keywords : aquatic insects * Malše river * České Budějovice Subject RIV: EH - Ecology, Behaviour

  10. La normalidad como excepción: la banalidad del mal, la conciencia y el juicio en la obra de Hannah Arendt

    Directory of Open Access Journals (Sweden)

    Marco Estrada Saavedra

    2007-01-01

    Full Text Available En este artículo, el autor expone la relevancia de las cuestiones morales en la obra de Hannah Arendt. Con este fin, se establece el significado de la fórmula "la banalidad del mal" para explicar las complejas conexiones entre el pensamiento, la conciencia y el juicio y cómo este circuito es destruido en el totalitarismo mediante la ideología, el terror y el aniquilamiento de la política.

  11. Timing of emergence and flight behavior of Oligoneuriella rhenana (Imhoff, 1852) (Ephemeroptera, Oligoneuriidae) at the Malše River (Novohradské Mountains, Czech Republic)

    Czech Academy of Sciences Publication Activity Database

    Soldán, Tomáš; Dresler, M.; Putz, M.; Maradová, M.

    České Budějovice : Jihočeská univerzita a Entomologický ústav AV ČR, 2003 - (Papáček, M.), s. 133-138 ISBN 80-7040-657-7 R&D Projects: GA AV ČR IBS5007015 Institutional research plan: CEZ:AV0Z5007907; CEZ:MSM 124100001 Keywords : Novohradské Mountains * Malše River * Ephemeroptera Subject RIV: EG - Zoology

  12. Transglycosylation properties of maltodextrin glucosidase (MalZ) from Escherichia coli and its application for synthesis of a nigerose-containing oligosaccharide

    International Nuclear Information System (INIS)

    The transglycosylation reaction of maltodextrin glucosidase (MalZ) cloned and purified from Escherichia coli K12 was characterized and applied to the synthesis of branched oligosaccharides. Purified MalZ preferentially catalyzed the hydrolysis of maltodextrin, γ-cyclodextrin (CD), and cycloamylose (CA). In addition, when the enzyme was incubated with 5% maltotriose (G3), a series of transfer products were produced. The resulting major transfer products, annotated as T1, T2, and T3, were purified and their structures were determined by TLC, MALDI-TOF/MS, 13C NMR, and enzymatic analysis. T1 was identified as a novel compound, maltosyl α-1,3-maltose, whereas T2 and T3 were determined to be isopanose and maltosyl-α-1,6-maltose, respectively. These results indicated that MalZ transferred sugar moiety mainly to C-3 or C-6-OH of glucose of the acceptor molecule. To obtain highly concentrated transfer products, the enzyme was reacted with 10% liquefied cornstarch, and then glucose and maltose were removed by immobilized yeast. The T1 content of the resulting reaction mixture reached 9.0%. The mixture of T1 containing a nigerose moiety can have an immunopotentiating effect on the human body and may be a potential functional sugar stuff.

  13. Surto de malária por Haemoproteus columbae em pombos An outbreak of malaria by Haemoproteus columbae in pigeons

    Directory of Open Access Journals (Sweden)

    J.S. Resende

    2001-06-01

    Full Text Available Relata-se um surto de malária por Haemoproteus columbae em pombos-correio (Columba livia, caracterizado por um quadro agudo com mortalidade de 3% ao dia em aves de aspecto saudável ou crônico com prostração e fraqueza. O exame clínico das aves doentes evidenciou sinusite e conjuntivite e à necropsia traqueíte hemorrágica, aerossaculite, esplenomegalia, nefromegalia e hepatomegalia com hemorragias. O díptero hematófago da família Hippoboscidae Pseudolynchia canariensis foi encontrado inserido entre as penas dos indivíduos. Esfregaços de sangue periférico e cardíaco e impressões de baço e fígado corados por Giemsa permitiram a visualização de inclusões intraeritrocitárias características de Haemoproteus columbae

  14. Malária no Brasil: panorama epidemiológico na última década

    Directory of Open Access Journals (Sweden)

    Barata Rita de Cássia B.

    1995-01-01

    Full Text Available Este artigo apresenta, de maneira resumida, as principais alterações que marcaram a ocorrência de malária, no Brasil, nesta última década. Chama-se a atenção para o processo de focalização da doença, com a concentração da transmissão em áreas, relativamente restritas, da região amazônica. A mudança na situação epidemiológica acarreta a revisãoconceitual, levando ao abandono da concepção de "doença de massa" e à elaboração da teoria focal. Do mesmo modo, as ações de controle sofrem os impactos das transformações ocorridas e as tentativas de erradicação são abandonadas e substituídas por medidas de controle diversificadas e adaptadas a cada localidade. As novas propostas, oriundas da Conferência Ministerial de Amsterdam, são apresentadas e comentadas.

  15. Encapsulating MAl 2O 4:Eu 2+, Dy 3+ (M = Sr, Ca, Ba) phosphors with triethanolamine to enhance water resistance

    Science.gov (United States)

    Ji, Ping Ting; Chen, Xiang Ying; Wu, Ye Qin

    2011-12-01

    Traditional aluminates phosphors with persistent luminescence are chemically unstable to water or moisture. Thus, how to improve the water-resistance of these phosphors is becoming a key issue in their practical applications. In this work, a series of alkaline earth aluminate phosphors including MAl 2O 4:Eu 2+, Dy 3+ (M = Sr, Ca, Ba) have been prepared by a co-precipitation synthesis and postannealing approach, using 8-hydroxyquinoline and sodium oxalate as precipitants. The samples before and after encapsulation were well characterized by means of XRPD, FESEM, FT-IR, TGA-DTG and PL techniques as well as water resistance measurements. The precipitants involved can react with Al 3+ and Sr 2+ (or Ca 2+, Ba 2+) to form complex compounds in aqueous solution, which further convert into porous phosphors by postannealing method under reducing atmosphere. Next, triethanolamine encapsulation at room temperature was conducted onto their surfaces to improve the water resistance. The results reveal that the encapsulation of aluminate phosphors with triethanolamine can effectively enhance the water resistance, and minimally affect on persistent phosphorescence.

  16. The utilization of a non-invasive fluorescence imaging system to follow clinical dermatological MAL-PDT

    Science.gov (United States)

    Tyrrell, Jessica; Campbell, Sandra; Curnow, Alison

    2009-06-01

    This study employed a commercially available, non-invasive, fluorescence imaging system (Dyaderm, Biocam, Germany), to measure protoporphyrin IX (PpIX) concentration at several different stages during clinical dermatological methyl aminolevulinate photodynamic therapy (MAL-PDT). We validated the system prior to use to ensure that the PpIX changes witnessed were accurate and not due to environmental or user induced artifacts. The system was then employed to acquire color (morphological) and fluorescent (physiological) images simultaneously during dermatological PDT. Clinical data was collected from a range of licensed dermatological conditions (actinic keratosis, Bowen's disease and superficial basal cell carcinoma) during initial and subsequent PDT treatment cycles. The initial clinical data indicated that each type of licensed lesion considered responded in a similar manner following the application of Metvix (Galderma, U.K.) and the subsequent light irradiation (Aktilite, Galderma, U.K.). Images acquired three hours after Metvix application showed a significant increase in PpIX concentration within the lesion (P < 0.05), whilst PpIX levels in the surrounding normal tissue remained unaltered. After irradiation, the PpIX concentration was significantly decreased and returned to a level similar to the initial concentration originally observed. Lesions that received subsequent treatment cycles accumulated significantly less PpIX (P < 0.05) prior to irradiation.

  17. Návrh malého proudového motoru do 1kN tahu

    OpenAIRE

    Gongol, Jakub

    2013-01-01

    Tato práce je zaměřena na téma malých proudových motorů. Práce je rozdělena na rešeršní a výpočtovou část. V rešeršní části se zabývá jak různými konfiguracemi proudových motorů, tak i oblastmi jejich použití. Hlavní část práce je výpočtová, kde bude navržen kompresor, turbína a výstupní tryska v takové konfiguraci, ve které bude motor při návrhovém režimu dávat tah 1kN. Dále bude vypočtena charakteristika motoru v mimonávrhových režimech, která dá představu o tom jak se motor bude chovat za ...

  18. Podnikatelský záměr pro založení malého podniku

    OpenAIRE

    Nováková, Petra

    2012-01-01

    Ve své bakalářské práci zpracovávám návrh podnikatelského plánu malého podniku. Pro tento záměr řešení jsem si vybrala klempířskou firmu. Řešená firma podniká jako fyzická osoba a vede daňovou evidenci. Návrh podnikatelského plánu se budu snažit zasadit do rámce dnešního ekonomického a politického prostředí a najít tak odpověď na otázku, zda je výhodné převést podnikání formou živnosti na podnikání formou právnické osoby – na společnost s ručením omezeným, tedy z fyzické osoby na osobu právni...

  19. An ecosystem approach to malaria control in an urban setting Uma abordagem ecossistêmica ao controle da malária em contexto urbano

    Directory of Open Access Journals (Sweden)

    Gabriel Carrasquilla

    2001-01-01

    Full Text Available We conducted a research project aimed at strengthening local government and the community for a sustainable malaria control strategy. The project began with a baseline diagnosis of malaria prevalence, a KAP survey, entomology, and health services delivery, after which an epidemiological study was performed to identify risk factors associated with malaria, thereafter used to plan intervention measures. A program evaluation was conducted five years later. By using an ecosystem approach to reanalyze data, this paper discusses how malaria arises from a complex interaction of cultural, economic, ecological, social, and individual factors. Intervention measures require an intersectorial and transdisciplinary approach that does not exist at the moment. Health sector leadership is limited, and there is no true community participation. Implications for research, including the use of qualitative and quantitative methods, study design, and complexity of data analysis are discussed. Finally, implications for malaria control are discussed, stressing the differences between the ecosystem and integrated disease control approaches.Os autores implementaram um projeto de pesquisa voltado ao fortalecimento do governo local e da comunidade com vistas à estratégia sustentável de controle da malária. O projeto iniciou com diagnóstico prévio, incluindo prevalência da malária, entomologia, KAP (conhecimentos, atitudes e práticas e oferta de serviços de saúde; a seguir, realizou-se inquérito epidemiológico para identificar fatores de risco associados à malária e a escolha de medidas de intervenção adequadas. O programa foi avaliado após cinco anos. Ao adotar a abordagem ecossistêmica para re-analisar os dados, o artigo discute como a malária surge a partir da interação complexa entre fatores culturais, econômicos, ecológicos, sociais e individuais. Medidas de intervenção exigem abordagem intersetorial e transdisciplinar ainda não existente. A

  20. Endocrinopatías en gatos diagnosticadas entre marzo de 2003 y marzo de 2011 en el Hospital Escuela de Medicina Veterinaria de la Facultad de Ciencias Veterinarias, Universidad de Buenos Aires Endocrinopathies in cats diagnosed between March 2003 and March 2011 in the Veterinary school Hospital, Faculty of Veterinary Science, University of Buenos Aires

    Directory of Open Access Journals (Sweden)

    M.M Zapata

    2011-06-01

    Full Text Available El objetivo de este estudio fue analizar la frecuencia de presentación de endocrinopatías diagnosticadas en la Unidad de Endocrinología del Hospital Escuela en el período comprendido entre marzo de 2003 y marzo de 2011. Se revisaron las historias clínicas de 40 gatos diagnosticados con diversas endocrinopatías. La diabetes mellitus representó el 47,5% (19/40 de los casos, el hipertiroidismo el 20% (8/40, el hipotiroidismo el 15% (6/40 y el SC el 10% (4/40, siendo los desórdenes endócrinos de mayor presentación en el gato en nuestro medio. Las enfermedades endócrinas fueron más prevalentes en los gatos adultos y gerontes (45%, 18/40 por cada grupo, representando en los jóvenes el 10% (4/40, siendo en esta franja etárea el hipotiroidismo la enfermedad endócrina más prevalente (75%, 3/4. En adultos y gerontes la diabetes mellitus fue la enfermedad más prevalente seguida del hipertiroidismo, enfermedades que no se registraron en el grupo de gatos jóvenes. Por sexo la distribución fue levemente superior en machos (55% que en hembras (45%, siendo en ambos sexos la diabetes mellitus la enfermedad más prevalente. Se concluye que, al menos en el período evaluado, la diabetes mellitus es la enfermedad más diagnosticada en el gato en nuestro medio, contrariamente a lo comunicado en el hemisferio norte donde lo es el hipertiroidismo. Esta patología se encuentra en segundo lugar, siendo seguida por el hipotiroidismo.The aim of this study was to analyze the frequency of endocrinopathies in cats diagnosed in the Endocrinology Unit of the Veterinary School Hospital, FCV-UBA in the period understood between March, 2003 and March, 2011. There were checked the case histories of 40 cats that were attendant in the mentioned institution. From the total of cases, Diabetes Mellitus represented 47.5% (19/40, the Hyperthyroidism was 20% (8/40, Hypothyroidism 15% (6/40 and Cushing's syndrome 10% (4/40, being the endocrine disorders more frequent in

  1. Causas de aborto bovino diagnosticadas no Setor de Patologia Veterinária da UFRGS de 2003 a 2011 Causes of bovine abortion diagnosed by the Sector of Veterinary Pathology of the Federal University of Rio Grande do Sul in the years 2003-2011

    Directory of Open Access Journals (Sweden)

    Nadia A.B. Antoniassi

    2013-02-01

    Full Text Available Descrevem-se as causas de aborto bovino diagnosticadas no Setor de Patologia Veterinária da Universidade Federal do Rio Grande do Sul no período de janeiro de 2003 a dezembro de 2011. Um total de 490 fetos bovinos foi analisado neste período. Causas específicas de aborto foram encontradas em 46,7% dos casos. Infecções por protozoários, em especial Neospora caninum acometeram 33% dos casos (162/490. Bactérias com 6,3% (31/490, seguidas por fungos com 0,8% (4/490 dos casos, foram causas adicionais de abortos. Em dois fetos (0,4%, coinfecções por dois agentes foram identificadas. Causas não-infecciosas foram observadas em 3% dos abortos e Malformações congênitas em 2,6%.The main causes of abortion in cattle diagnosed from January 2003 to December 2011 are described. A total of 490 fetuses from several Brazilian states were evaluated. Specific causes of abortion were found in 46.7% of the cases,and protozoan abortions, especially by Neospora caninum, were detected in 33% (162/490. Bacterial abortions corresponded to 6.3 % (31/490, followed by fungal ones to 0.8% (4/490. In two aborted fetuses (0.4 %, a co-infection with two agents could be identified. Non-infectious diseases could be associated with 3% of the abortions and congenital malformations with 2.6%.

  2. «Gente de mal vivir»: families and incorrigible sons in new Spain, 1721-1729

    Directory of Open Access Journals (Sweden)

    Cáceres Menéndez, Beatriz

    2006-08-01

    Full Text Available Forced transportation to the Philippine and Mariana Islands, a form of social exile and the equivalent of deportation, was used in New Spain to punish criminals and people judged to be undesirable. Those who were sent across the Pacific were always male and usually American-born Spaniards. Both the viceregal government and parents thought forced transportation to be an appropriate way to rid Mexico not only of criminals but also of men «of evil living» - people whose lives were dedicated to gambling, public drunkenness, idleness, and immorality. Parents, brothers, and even wives therefore used forced transportation to eliminate unwanted family members whose behavior threatened to tarnish family honor.

    En la Nueva España el traslado forzoso de individuos a las Islas Filipinas y Marianas fue una forma de exilio equivalente a la deportación para castigar a los criminales y a la gente considerada indeseable. Los condenados fueron siempre hombres y usualmente españoles nacidos en América. Tanto el gobierno virreinal como los padres de familia pensaron en el traslado forzoso como un medio apropiado para limpiar el Reino no sólo de criminales sino también de «gente de mal vivir», es decir, aquellos dedicados al juego, la embriaguez pública, la ociosidad y la inmoralidad. Padres, hermanos y aún esposas utilizaron el traslado obligado como un medio para eliminar a los familiares cuyos comportamientos amenazaban manchar el honor de la familia.

  3. Malária ocular: estudo histopatológico experimental das alterações coriorretinianas Ocular malaria: experimental histopathological study of choroidal and retinal changes

    Directory of Open Access Journals (Sweden)

    Paulo Roberto de Magalhães Silva

    2003-06-01

    Full Text Available OBJETIVO: Realizar análise histopatológica dos tecidos uveal e retiniano em modelo murino que fortemente se assemelha ao desenvolvimento de malária cerebral humana, correlacionando as alterações oculares com achados encontrados em órgãos-alvo como o cérebro. MÉTODOS: Utilizamos camundongos de linhagem isogênica CBA/J por desenvolverem malária e evoluírem para forma grave ou cerebral quando inoculados com Plasmodium berghei (ANKA. Foi realizada inoculação via intraperitoneal e a parasitemia obtida diariamente. Para correlacionarmos as alterações com a evolução da malária, os camundongos foram sacrificados no 3º, 7º e 9º dia de infecção. Após a enucleação, o globo ocular foi fixado em solução de Bouin e incluído em parafina. Os cortes foram corados com hematoxilina-eosina, tricrômica de Gomori e Giemsa. RESULTADOS: Foram observados acúmulos de pigmentos maláricos (hemozoína em diversas estruturas oculares, na fase inicial da doença, até alterações endoteliais de vasos retinianos, adesão de monócitos na parede vascular e congestão do lúmen vascular por hemácias parasitadas (seqüestro em tecido uveal na fase tardia da infecção. Os níveis de parasitemia mostraram curva ascendente e significativa por volta do sétimo dia. Neste modelo observamos alterações semelhantes àquelas encontradas em outros órgãos-alvo como o cérebro. CONCLUSÕES: O modelo de malária murina permite a correlação dos achados oculares com outros órgãos-alvo da infecção. O seqüestro de células vermelhas parasitadas, na fase tardia, é responsável pela maioria das alterações oculares da malária, provavelmente com base nos fenômenos obstrutivos similares aos processos que envolvem o sistema nervoso central.PURPOSE: To accomplish a histopathological analysis of ocular structures, that is, uveal and retinal tract in a murine model that closely resembles human cerebral malaria and to correlate the ocular alterations with

  4. MosquitoMap and the Mal-area calculator: new web tools to relate mosquito species distribution with vector borne disease

    Directory of Open Access Journals (Sweden)

    Christensen Jamie

    2010-02-01

    Full Text Available Abstract Background Mosquitoes are important vectors of diseases but, in spite of various mosquito faunistic surveys globally, there is a need for a spatial online database of mosquito collection data and distribution summaries. Such a resource could provide entomologists with the results of previous mosquito surveys, and vector disease control workers, preventative medicine practitioners, and health planners with information relating mosquito distribution to vector-borne disease risk. Results A web application called MosquitoMap was constructed comprising mosquito collection point data stored in an ArcGIS 9.3 Server/SQL geodatabase that includes administrative area and vector species x country lookup tables. In addition to the layer containing mosquito collection points, other map layers were made available including environmental, and vector and pathogen/disease distribution layers. An application within MosquitoMap called the Mal-area calculator (MAC was constructed to quantify the area of overlap, for any area of interest, of vector, human, and disease distribution models. Data standards for mosquito records were developed for MosquitoMap. Conclusion MosquitoMap is a public domain web resource that maps and compares georeferenced mosquito collection points to other spatial information, in a geographical information system setting. The MAC quantifies the Mal-area, i.e. the area where it is theoretically possible for vector-borne disease transmission to occur, thus providing a useful decision tool where other disease information is limited. The Mal-area approach emphasizes the independent but cumulative contribution to disease risk of the vector species predicted present. MosquitoMap adds value to, and makes accessible, the results of past collecting efforts, as well as providing a template for other arthropod spatial databases.

  5. Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection

    OpenAIRE

    Valkov, Eugene; Stamp, Anna; DiMaio, Frank; Baker, David; Verstak, Brett; Roversi, Pietro; Kellie, Stuart; Sweet, Matthew J.; Mansell, Ashley; Gay, Nicholas J.; Jennifer L Martin; Kobe, Bostjan

    2011-01-01

    Initiation of the innate immune response requires agonist recognition by pathogen-recognition receptors such as the Toll-like receptors (TLRs). Toll/interleukin-1 receptor (TIR) domain-containing adaptors are critical in orchestrating the signal transduction pathways after TLR and interleukin-1 receptor activation. Myeloid differentiation primary response gene 88 (MyD88) adaptor-like (MAL)/TIR domain-containing adaptor protein (TIRAP) is involved in bridging MyD88 to TLR2 and TLR4 in response...

  6. « Satan ou la Majesté maléfique dans les miniatures de la fin du Moyen Age »

    OpenAIRE

    Baschet, Jérôme

    1995-01-01

    Cet article étudie les représentations de Satan dans l'iconographie de la fin du Moyen Age, en particulier la tension entre une représentation multiforme de la prolifération diabolique et la concentration du mal dans la figure du "prince de ce monde". A travers plusieurs thèmes (Chute des anges, miracle de Théophile notamment), on analyse l'émergence d'une figuration de la Majesté de Satan et ses implications dans l'ensemble du système de représentation tardo-médiéval.

  7. Linkage map positions and allelic diversity of two Mal d 3 (non-specific lipid transfer protein) genes in the cultivated apple (Malus domestica)

    OpenAIRE

    Gao, Z. S.; Weg, van de, H; Schaart, J.G.; Meer, van der, D; Kodde, L.P.; Laimer, M; Breiteneder, H; K. Hoffmann-Sommergruber; Gilissen, L.J.W.J.

    2005-01-01

    Non-specific lipid transfer proteins (nsLTPs) of Rosaceae fruits, such as peach, apricot, cherry, plum and apple, represent major allergens for Mediterranean atopic populations. As a first step in elucidating the genetics of nsLTPs, we directed the research reported here towards identifying the number and location of nsLTP (Mal d 3) genes in the apple genome and determining their allelic diversity. PCR cloning was initially performed on two cultivars, Prima and Fiesta, parents of a core apple...

  8. A banalização do mal: sobre Auschwitz, a religião do cotidiano e a teoria social

    Directory of Open Access Journals (Sweden)

    Detlev Claussen

    2013-07-01

    Full Text Available Neste artigo, traduzido para o português por Rodrigo Duarte, Detlev Claussen discute a banalização do mal a partir da relação da indústria cultural com Auschwitz. O autor sugere que a substituição dessa palavra pelo termo mais geral “holocausto” é uma das estratégias empregadas pelos meios de massa para trivializar a comunicabilidade do que se passou nesse campo de concentração – uma experiência que permanece essencialmente incomunicável.

  9. Estudo comparativo não randomizado do midazolam versus thiopental em crianças com estado de mal epiléptico refratário

    OpenAIRE

    LÖHR JUNIOR ALFREDO; WERNECK LINEU CESAR

    2000-01-01

    Avaliamos o uso do midazolam em relação ao thiopental em crianças com estado de mal epiléptico refratário(EMER). Foram estudadas 50 crianças com EMER, internadas em UTI-pediátrica, composto pelos: Grupo Midazolam(A) (n=24) prospectivo, e o Grupo Thiopental(B) (n=26) histórico. Benzodiazepina e difenil-hidantoina e outros anticonvulsivantes foram previamente utilizadas nos dois grupos. Não havendo o controle das convulsões, no Grupo A os pacientes receberam uma dose de 200 mig/kg midazolam int...

  10. Malária em grávidas de uma maternidade pública de Rio Branco (Acre, Brasil) Malaria in pregnant women of a public maternity of Rio Branco (Acre State, Brazil)

    OpenAIRE

    Regina Jarude; Ronald Trindade; José Tavares-Neto

    2003-01-01

    OBJETIVO: descrever a freqüência dos achados clínico-laboratoriais em grávidas portadoras de malária. MÉTODOS: foi realizado estudo descritivo, série de casos, de 445 grávidas da Maternidade e Clínica de Mulheres Bárbara Heliodora (Rio Branco, Acre), do período de janeiro de 1996 a dezembro de 2001, com diagnóstico parasitológico de malária. Foram revistos os prontuários do período e selecionados os casos portadores de malária. RESULTADOS: no total de pacientes (n=33.420) internadas no períod...

  11. Aptitud combinatoria entre líneas de maíz resistentes a Mal de Río Cuarto

    Directory of Open Access Journals (Sweden)

    Morata Mónica M.

    2003-01-01

    Full Text Available Se realizó un experimento dialélico entre nueve líneas de maíz (Zea mays (Método 4, modelo I de Griffing (1956 con el objeto de determinar Aptitud combinatoria general y específica (ACG y ACE para Resistencia a Mal de Río Cuarto (MRC. Los ambientes seleccionados fueron Pergamino, Junín, Ferré (región maicera VI y Sampacho y Holmberg (región maicera IV. La severidad de la enfermedad, evaluada a través del Grado Medio de Ataque (GMA, resultó nula en Pergamino y Junín, y de 0,14 en Ferré, con diferencias significativas entre tratamientos. En Holmberg fue de 0,59 y en Sampacho 1,57. El análisis de variancia para esta región detectó diferencias significativas entre ambientes y entre tratamientos, no detectándose interacción. El GMA promedio de los híbridos experimentales no se diferenció del promedio los testigos resistentes, si lo hizo de los testigos comerciales (más susceptibles. Veinticinco materiales experimentales no se diferenciaron del mejor de los testigos resistentes. La selección por pedigrí fue efectiva para mejorar este carácter. Los materiales experimentales en general demostraron poseer características que les darían competitividad en el mercado. Por su ACG, las líneas más resistentes a MRC fueron la 2526 y la 2378 (con efectos significativos y negativos: resistentes por los efectos de ACE, se destacaron los híbridos: 2378 x 2600, 2335 x 2600, LP561 x 2568-2 y 2526 x 2600. En Sampacho el 42% de la disminución en el rendimiento pudo atribuirse al MRC, en Holmberg el 8%.

  12. Malária humana: padronização e optimização de testes sorológicos para diagnóstico individual e inquéritos soroepidemiológicos

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    Antonio Walter Ferreira

    1988-06-01

    Full Text Available O teste de imunofluorescência indireta (IFI é considerado teste de referência na soroiogia da malária. Neste trabalho procuramos optimizar o teste empregando P. falciparum obtido de sangue humano e de cultura e P. vivax obtido de sangue de paciente como antígenos, para pesquisa de anticorpos IgG e IgM. Das variáveis técnicas estudadas melhores resultados foram obtidos quando os soros foram diluidos ern PBS contendo 1% de Tween 80 e as lâminas contendo a suspensão antigênica foram estabilizadas em dessecadores ou fixadas com acetona. Foi também padronizado o teste imunoenzimático ELISA com antigenos de P. falciparum obtidos em cultura. O estudo comparativo com o teste de imunofluorescência indireta para pesquisa de anticorpos IgG mostrou: a nos pacientes primo infectados por P. falciparum a sensibilidade para ambos os testes foi de 71%; b nos pacientes primo infectados pelo P. vivax a sensibilidade foi de 40% para ambos os testes; c nos pacientes não primo infectados e com malária atual pelo P. falciparum a sensibilidade para ambos os testes foi de 100%; d nos pacientes não primo infectados e com malária atual pelo P. vivax a sensibilidade foi de 85% para o teste ELISA e de 92% para a IFI; e nos pacientes com malária mista a sensibilidade para ambos os testes foi de 100%. A especificidade da IFI foi de 100% e do teste ELISA 95% nos casos de indivíduos não maláricos. Os resultados obtidos sugerem ser o teste ELISA, uma boa alternativa para o teste de IFI, para a pesquisa de anticorpos IgG anti P. falciparum, na soroiogia da malária.

  13. Retardo no crescimento intrauterino, baixo peso ao nascer e prematuridade em recém-nascidos de grávidas com malária, na Colômbia

    Directory of Open Access Journals (Sweden)

    Alberto Tobón-Castaño

    2011-06-01

    Full Text Available INTRODUÇÃO: É frequente a associação da malária com complicações como prematuridade, retardo no crescimento intrauterino, baixo peso ao nascer e mortalidade infantil, efeitos pouco estudados em áreas hipoendêmicas para malaria. O objetivo deste estudo foi analisar a relação da malária gestacional com estes efeitos em recém-nascidosnuma região endêmica para malária na Colômbia, entre 1993 e 2007. MÉTODOS: Foram estudadas as características em 1.716 recém-nascidos num estudo de coorte. Fez-se seguimento em 394 gestantes com malária (27% por Plasmodium falciparum e 73% por P. vivax e 1.322 sem malária. RESULTADOS: Foi encontrada uma relação entre a exposição à malária na gestação e o risco maior de baixo peso ao nascer (RR = 1,37; 1,03-1,83, assim como estatura baixa (RR = 1,52; 1,25-1,85, retardo no crescimento intrauterino (RR = 1,29; 1,0-1,66 e prematuridade (RR = 1,68; 1,3-2,17. A frequência de nascimentos prematuros foi maior nas mães com malária por P. falciparum (77% que aquelas com P. vivax (RR = 1,77; IC 95%: 1,2-2,6. CONCLUSÕES: O baixo peso ao nascer e o retardo no crescimento foi associado com malária na gestação na Colômbia. A infecção por P. vivax foi relacionada com efeitos adversos sobre o recém-nascido, de modo semelhante em relação ao P. falciparum.

  14. Biocontrol con Trichoderma spp. de Fusarium oxysporum causal del “mal de almácigos” en pre y post emergencia en cebolla

    OpenAIRE

    Sánchez, Aixa D.; Barrera, Viviana; Reybet, Graciela; Sosa, M. Cristina

    2015-01-01

    En Argentina, la “podredumbre basal” y el “mal de almácigos” causados por el complejo Fusarium spp. constituyen uno de los problemas más serios en cebolla. En este trabajo se estudió el uso de especies del género Trichoderma como agentes de control biológico (ACB) de F. oxysporum, causal del “mal de almácigos” en cebolla. Se identificaron y caracterizaron morfológica, cultural y fisiológicamente a 10 aislamientos de Trichoderma spp. del cepario de Fitopatología. Por secuenciación del gen TEF-...

  15. Rozšíření a struktura populací střevle potoční (Phoxinus phoxinus) v povodí Malše

    OpenAIRE

    LUKEŠ, Václav

    2010-01-01

    This thesis was elaborated within the MSM 6007665801 research intention. The objective of the thesis was to create an overview of the distribution of Common Minnow in the basin of upper and middle reaches of the Malše River. Selected stretches of the Malše River, Černá River and Pohořský, Huťský, Tisový and Žďárský Brooks were monitored. These streams correspond to trout waters in their character. The field research was conducted in the years 2005?2008. Estimates of quantity and indexes of di...

  16. EL «MAL IDEOLÓGICO»: DESCRIPCIÓN Y CRÍTICA DE UNA POLÍTICA CONTRARIA A LA NATURALEZA HUMANA

    Directory of Open Access Journals (Sweden)

    Aquilino Cayuela Cayuela

    2012-01-01

    Full Text Available El mal ideológico consiste en situar ciertos ideales por encima de la persona humana real y concreta, y ha sido un elemento presente en las políticas totalitarias del siglo XX, particularmente aquellas que han desprotegido la vida y dignidad de los seres humanos. En la actualidad este mal ideológico se encarna en los impulsos políticos y legislativos que reducen el ámbito de protección de la vida y cuestionan de la dignidad de los estados de vida frágiles (neonatos, enfermos mentales, moribundos. El caso más importante en la España actual ha sido la reciente Ley Orgánica 2/2010, ley claramente ideológica, carente de argumentos que promocionen la humanidad y muy por el contrario una ley de plazos que sitúa la vida de los futuros ciudadanos en un peligroso espacio de desprotección y antepone dudosos derechos subjetivos y pulsiones ideológicas a una fuerte valoración de la dignidad humana y a los derechos fundamentales que de ella se derivan con son, en este caso la protección de la vida y la libertad de conciencia.

  17. Návrh malého jaderného reaktoru pro účely dodávek tepla

    OpenAIRE

    Bobčík, Marek

    2013-01-01

    Úkolem této diplomové práce je posouzení vhodnosti využití malého jaderného reaktoru pro účely dodávek tepla. Toto řešení je dimenzováno především pro menší města. Jsou analyzovány veškeré potřeby dodávky tepla s následným návrhem malého jaderného reaktoru. Vytvoření výpočtového modelu vyhořívání paliva. Cílem je návrh tepelného výměníku. Práce bere v úvahu ekonomické a environmentální hledisko, včetně bezpečnostních opatření. Výstupem diplomové práce je posouzení vhodnosti této koncepce pro ...

  18. Možnosti využití ITIL v prostředí malých a středních firem

    OpenAIRE

    Matějka, Marek

    2006-01-01

    Práce se zabývá možnostmi využití nejlepších praktik ITIL v prostředí malých a středních podniků (SMB). Hlavním smyslem je pak zhodnocení ITIL z pohledu SMB sektoru a nalezení styčných ploch, které jsou pro tyto firmy aplikovatelné. Jednotlivé kapitoly se pak věnují konkrétním cílům. První obsahová kapitola definuje pojmy a uvádí čtenáře do problematiky. Text se postupně zaměřuje na problematiku malých a středních firem, jejich ekonomické situace a manažerského přístupu. Další část je věnován...

  19. Speleogenesis of the Havranická Cave as an important phenomenon of the Plavecký Karst (Malé Karpaty Mts.

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    Tomáš Lánczos

    2013-06-01

    Full Text Available The investigation of the Havranická Cave situated in the northern part of the Malé Karpaty Mts. included geological, mineralogical, geochemical, and microbiological methods aimed at the explanation of the speleogenesis of the cave. The karstifikation process in the Malé Karpaty Mts. started in the Pliocene at earliest, after emerging the mountains, what performed during the Upper Miocene. The origin of the investigated cave is connected with the N–S directed fault, activated during the Pliocene–Quaternary. The material deposited into the crevices of the cave walls was undergone by mineralogical study showing mainly allochtonous clayey material strongly calcified by percolating water. The XRD analyses identified clayey minerals like kaolinite, chlorite, and illite. The chemical composition of a water sample from a small pool collecting the percolation water was investigated. Following the thermodynamical calculations the water is equilibriated with calcite and dolomite under circumstances of CO2 partial pressure (pCO2 approximately ten times higher then the pCO2 value of the atmosphere causing more intensive carbonate dissolution. The microbiological investigation of the cave sediments identified ten species of microscopic fungi, mostly represented by genus Aspergillus and Penicillum.

  20. Portfolio management pro malé a střední společnosti v oblasti podnikání ICT

    OpenAIRE

    Altschmied, Martin

    2008-01-01

    Cílem práce je zařadit koncept IT Portfolio Management do kontextu strategického řízení firmy a dále navrhnout model IT Portfolio Managementu, který by byl universálně použitelný v malých a středních podnicích. Model zohledňuje odlišnosti malých a středních podniků a zestručňuje obecný postup implementace IT Portfolio Managementu popsaný v literatuře tak, aby byl lépe srozumitelný pro management takovýchto podniků. Přínos autora je zejména v syntéze teoretických poznatků s praktickými zkušeno...

  1. Borçlunun üçüncü kişilerdeki mal, hak ve alacaklarının haczi

    OpenAIRE

    İYİLİKLİ, Ahmet Cahit

    2011-01-01

    Borçlunun üçüncü kişilerdeki mal, hak ve alacaklarının hacziİcra ve İflâs Kanunu 89. madde uygulaması, günümüzde sıkça rastlanılan bir hukuki müessesedir. Zira borçluya karşı icra ya da İflâs takibini kesinleştirmiş olan takip alacaklısı, takip borçlusunun üçüncü kişilerdeki mal, hak ve alacağını dondurup, bir an evvel alacağına kavuşmak istemektedir. İcra ve İflâs Kanunu 89. madde düzenlemesi, elbette takip alacaklısının, takip borçlusunun üçüncü kişilerde gerçekte var olan alacağın...

  2. Lady Mal-Beth

    OpenAIRE

    Guarinos, Virginia

    2007-01-01

    En la historia de Macbeth hay un personaje que ha compartido con el protagonista el interés del público. Es Lady Macbeth. Símbolo de maldad y de ambición, Lady Macbeth se ha convertido en un estereotipo que ha traspasado las barreras de su propio continente literario-teatral. Ello merece un acercamiento a su perfil, desde la perspectiva contemporánea de la Teoría Fílmica Feminista, así como a las diversas construcciones que de ella han elaborado los tres principales directores de cine que han...

  3. Nevus sebáceo de Jadassohn: descripción de 261 casos y su asociación con otros tumores

    OpenAIRE

    Paula Andrea Arango Pérez; Clara Inés Hurtado Bernal; Natalia Andrea Orjuela Toro; Carlos E. Montealegre G.; Juan Carlos Wolff I.; Luis Alfonso Correa L.; Gabriel Ceballos C.

    2008-01-01

    El nevus sebáceo de Jadassohn (NSJ) es una lesión congénita benigna pero por decenios se la consideró con alto potencial de malignización hacia el carcinoma basocelular (CBC), por lo que se sugería su resección precoz. Series recientes han establecido que muchas de las neoplasias diagnosticadas como malignas eran benignas. Nuestra revisión de 261 casos constituye un aporte al conocimiento del NSJ. Hasta ahora no ha habido series similares en Colombia, y en América Latina las publicaciones no ...

  4. Intoxicações por plantas diagnosticadas em ruminantes e equinos e estimativa das perdas econômicas na Paraíba Plant poisonings diagnosed in ruminants and horses and estimation of the economical losses in Paraíba

    Directory of Open Access Journals (Sweden)

    Tales S. Assis

    2010-01-01

    Full Text Available Foi realizado um levantamento dos surtos de intoxicações por plantas em ruminantes e equinos diagnosticados no Laboratório de Patologia Veterinária (LPV, do Hospital Veterinário da Universidade Federal de Campina Grande, Campus de Patos, Paraíba, no período de 2000-2007. Em bovinos 7,4% dos diagnósticos realizados pelo LPV foram intoxicações por plantas. Foram diagnosticadas intoxicações por Centhraterum brachylepis (um surto, Brachiaria spp. (um surto, Crotalaria retusa (dois surtos, Ipomoea batatas (um surto, Marsdenia sp. (um surto, gramíneas contendo nitratos e nitritos (um surto por Echinochloa polystachya e dois surtos por Pennisetum purpureum, Palicourea aeneofusca (um surto, Prosopis juliflora (três surtos, Nerium oleander (um surto e Mimosa tenuiflora (sete surtos. Na espécie ovina 13% dos diagnósticos foram intoxicações por plantas. Os surtos foram causados por Ipomoea asarifolia (quatro surtos, Brachiaria spp. (três surtos, Crotalaria retusa (dois surtos, Tephrosia cinerea (dois surtos, Panicum dichotomiflorum (um surto, Mascagnia rigida (um surto e malformações associadas à ingestão de Mimosa tenuiflora (20 surtos. Nos caprinos, 6,4% dos diagnósticos corresponderam à intoxicação por plantas. Sete surtos foram causados por Mimosa tenuiflora, um por Ipomoea asarifolia, um por Ipomoea carnea, um por Ipomoea riedelli, três por Prosopis juliflora, um por Arrabidaea corallina, dois por Aspidosperma pyrifolium, dois por Turbina cordata e um por Opuntia ficus-indica. Na espécie equina 14% das doenças diagnosticadas foram devidas a intoxicações por plantas, sendo 12 surtos por Crotalaria retusa e um por Turbina cordata. As perdas na Paraíba por plantas tóxicas são estimadas em 3.895 bovinos, 8.374 ovinos, 6.390 caprinos e 366 equinos, que representam uma perda econômica anual, por morte de animais, de R$ 2.733.097,00. São relatados alguns aspectos epidemiológicos, sinais clínicos e patologia de surtos de

  5. Malaria infection and the anthropological evolution Infecção por Malária e evolução antropológica

    Directory of Open Access Journals (Sweden)

    Sergio Sabbatani

    2010-03-01

    malária exerceu papel biológico chave, influenciando até o desenvolvimento antropológico. Os Plasmódios causadores da malária desenvolveram dois tipos de evolução, segundo um ponto de vista biológico, e filogenético. Em particular, os Plasmódios vivax, malariae, e ovale poderiam ter coevoluído com a espécie humana ou ter atingido esta durante as fases mais antigas da evolução do gênero HOMO. Por outro lado, o Plasmódio falciparum teria sido transmitido aos humanos por macacos num período mais recente, provavelmente entre o fim da Idade Mesolítica e o início da Neolítica. Os Autores mostram evidências biomoleculares, tanto diretas como indiretas, de infecção por malária, observada em indivíduos enterrados, reportando ao Mundo Antigo, e trazidas à luz no decorrer de escavações arqueológicas em alguns sítios relevantes Mediterrâneos. Nesta revisão da literatura, os autores organizam evidências modernas. Confirmam o papel da malária ao afetar a evolução das populações no Mediterrâneo. As pessoas que moram nas várias regiões do Mediterrâneo foram progressivamente influenciadas pela malária, ao longo do avanço desta doença. Além disso, as populações afetadas desenvolveram adaptações culturais, alimentares, e de comportamento, contribuindo para uma redução no risco da doença. Entretanto, pode ser que ambas modificações (as biológicas e as dos hábitos usadas pelos Plasmódios da malária, favoreceram a emergência de grupos de pessoas com maior resistência contra a malária. Todos estes fatores considerados reduziram o impacto demográfico, influenciando de uma maneira favorável o desenvolvimento em geral, e o crescimento da civilização.

  6. Nanotecnologia farmacêutica aplicada ao tratamento da malária Application of pharmaceutical nanotechnology to the treatment of malaria

    Directory of Open Access Journals (Sweden)

    Lúcio Figueira Pimentel

    2007-12-01

    Full Text Available Apesar do desenvolvimento tecnológico e científico, a malária permanece como um dos maiores problemas de saúde a serem combatidos. As estratégias modernas para o controle da doença prevêem ações conjuntas, como o combate do inseto vetor, diagnóstico rápido e preciso, garantia de terapêutica adequada, redução dos casos de resistência, além do desenvolvimento de novos agentes terapêuticos e vacina e através da otimização da ação de fármacos utilizados na atualidade. Os sistemas de liberação controlada de fármacos vêm recebendo atenção especial nesta área de pesquisa, com o desenvolvimento de estratégias para a veiculação de agentes bioativos e vacinas na forma de nanodispositivos tais como lipossomas, nanopartículas e micropartículas. Diversos nanossistemas já demonstraram eficácia na otimização de vacinas e quimioterápicos destinados ao controle da malária. Este artigo de revisão tem por objetivo avaliar o estado da arte na terapêutica da malária e demonstrar o potencial da nanotecnologia farmacêutica como ferramenta destinada ao combate da doença.In spite of living in a scientific and technological era, malaria continues to be one of the worldwide greatest health challenges. The state-of-the-art policy to keep malaria under control is expected to comprise joint-strategies, such as the vector control, fast diagnosis, therapeutic guarantee, resistance cutback, drug optimization and development of new therapeutic agents and vaccines. Nano and microcarrier systems have been receiving a special attention, including the development of strategies for carrying bioactive agents, vaccines through nanodevices, such as liposomes and nanoparticles, and microdevices, such as microparticles and microemulsions. Numerous nanosystems have already substantiated their effectiveness to optimize vaccines, insecticides, and chemotherapeutic agents applied to the control of malaria. This review is intended to explain the

  7. Návrh zabezpečení počítačové sítě malé softwarové firmy

    OpenAIRE

    Špičák, Jan

    2010-01-01

    Bakalářská práce předkládá analýzu stavu současného zabezpečení počítačové sítě a následné optimalizaci v malé softwarové firmě. Předkládá návrhy jak zlepšit zabezpečení, které mohou zabránit útokům z internetu a ztrátě důležitých informací.

  8. Ajuste rápido de dosis de tapentadol en el tratamiento del dolor mal controlado Fast titration of tapentadol for the treatment of badly controlled pain

    OpenAIRE

    M. J. Sánchez del Águila; R. González López; A. D. Ballesteros Chaves; F. Robles Domínguez; L. F. Valdés Vilches; P. Alonso Atienza

    2012-01-01

    Introducción: el tapentadol es un nuevo fármaco de acción dual MOR/NRI, que actúa a nivel central, efectivo en el tratamiento del dolor moderado e intenso, que presenta un perfil de tolerabilidad mas favorable que otros opiáceos. Esto podría permitir una titulación rápida que permita un control precoz del dolor. Material y métodos: presentamos dos casos clínicos en los que se realiza una titulación rápida de la dosis de tapentadol en pacientes hospitalizados con dolor mal controlado. Este aju...

  9. Řízení informatiky v malých a středních podnicích

    OpenAIRE

    Šmerda, Miroslav

    2007-01-01

    Bakalářská práce pojednává o řízení informatiky vzhledem k nejvíce uznávaným rámcům. ITIL jako jeden z těchto rámců je pak blíže popsán a také porovnán s rámcem CobiT s ohledem na využití v malých a středních podnicích. Druhá část této práce je zaměřena na specifika řízení informačního systému v tomto sektoru ekonomiky.

  10. De la malédiction littéraire : entre mélancolie, pauvreté et persécution

    Directory of Open Access Journals (Sweden)

    Buata Malela

    2007-03-01

    Full Text Available Le dernier ouvrage de Pascal Brissette se propose de reconstituer le mythe de la malédiction littéraire sur une période allant du Moyen Âge au XIXe siècle (p. 16. Pour saisir la complexité d’un tel sujet, Pascal Brissette choisit un axe multidisciplinaire en joignant la sociologie de la littérature, la sociocritique des textes et l’histoire de la littérature (p. 17. Son but est de réfléchir à la fonction du malheur dans les processus de légitimation culturelle en étudiant les formes variées...

  11. Comment inciter les régulations métacognitives pour favoriser la résolution de problèmes mal structurés?

    OpenAIRE

    Gagniere, Laurence

    2010-01-01

    Parvenir à inciter les processus métacognitifs à l'oeuvre dans des résolutions de problèmes mal structurés constitue un enjeu important. Ces processus sont en effet requis mais rarement mobilisés de façon spontanée. Trois études ont été proposées, afin de vérifier les effets positifs de différents types d'incitations métacognitives sur l'émergence de régulations métacognitives et sur les performances à des problèmes peu structurés. Les résultats ont permis d'une part, de clarifier la nature e...

  12. Causas mal definidas de morte e óbitos sem assistência Ill-defined causes of death and unattended deaths, Brazil, 2003

    Directory of Open Access Journals (Sweden)

    Augusto Hasiak Santo

    2008-02-01

    Full Text Available OBJETIVOS: Este trabalho estuda a distribuição dos óbitos por causas mal definidas no Brasil, no ano de 2003, entre as quais identifica a proporção de mortes sem assistência. MÉTODOS: Os dados provieram do Sistema de Informações Sobre Mortalidade, coordenado pelo Ministério da Saúde. As causas mal definidas de morte compreenderam as incluídas no "Capítulo XVIII - Sintomas, sinais e achados anormais de exames clínicos e de laboratório não classificados em outra parte" da Classificação Estatística Internacional de Doenças e Problemas Relacionados à Saúde, décima revisão, capítulo este no qual a categoria R98 identificava a "morte sem assistência". RESULTADOS: No Brasil, em 2003, a causa básica de 13,3% dos óbitos foi identificada como mal definida, sendo que as proporções maiores ocorreram nas Regiões Nordeste e Norte. Do total de causas mal definidas no país, 53,3% corresponderam a mortes sem assistência, proporção esta que superou 70% nos Estados do Maranhão, Piauí, Rio Grande do Norte, Pernambuco, Bahia, Paraíba e Alagoas. CONCLUSÃO: Dada a estrutura descentralizada para o levantamento dos óbitos no país, identifica-se a maior responsabilidade dos municípios e, em seguida, dos Estados para o aprimoramento da qualidade das estatísticas de mortalidade.BACKGROUND: We studied the distribution of deaths from ill-defined causes that occurred in Brazil during 2003, from which was identified the proportion of unattended deaths. METHODS: Data were obtained from the Mortality Information System, coordinated by the Ministry of Health. Causes of death included in "Chapter XVIII - Symptoms, signs and abnormal clinical and laboratory findings, not classified elsewhere" of the International Statistical Classification of Diseases and Related Health Problems, tenth revision, were considered ill-defined, among which the category R98 identified "unattended deaths". RESULTS: In Brazil during 2003 the underlying causes of

  13. Claude Liauzu, Empire du mal contre Grand Satan. Treize siècles de cultures de guerre entre l’islam et l’Occident

    OpenAIRE

    Michon, Bruno

    2010-01-01

    Avec Empire du mal contre Grand Satan, Claude Liauzu, nous livre une étude ambitieuse des relations entre l’islam et le christianisme. Pour être plus exact, il cherche à se repérer dans «les atlas mentaux» – terme qu’il reprend à Fernand Braudel – qui résultent depuis des siècles des confrontations entre l’Orient islamique et l’Occident chrétien. C’est bien l’ambition de cet ouvrage que de résumer quatorze siècles d’histoire. L’objectif sous-jacent est toutefois plus qu’historique: C. Liauzu ...

  14. Aplikace mezinárodního účetního standardu pro malé a střední firmy

    OpenAIRE

    Letková, Nina

    2015-01-01

    Diplomová práca sa zaoberá aplikáciou medzinárodného účtovného štandardu vykazovania pre malé a stredné podniky. Predmetom práce je definovať základný rámec pre vykazovanie podľa IFRS pre SME, analyzovať rozdiely medzi českou účtovnou legislatívou a vykazovaním podľa IFRS pre SME a následne aplikovať nadobudnuté vedomosti v praktickej časti spolu s definovaním nákladov a prínosov spojených s prechodom na IFRS pre SME.

  15. Efeito dos factores do hospedeiro e parasitários na susceptibilidade à Malária e gravidade da Doença

    OpenAIRE

    Monteiro, Maria Fernanda

    2012-01-01

    A malária é considerada como a doença parasitária mais séria em humanos, infectando cerca de 5 a 10% da população mundial, estimando-se entre 300 a 600 milhões de casos e mais de dois milhões de mortes, anualmente. Apesar da severidade da doença, a compreensão da variabilidade da resposta do hospedeiro à infecção (traduzida desde a infecção silenciosa até formas crónicas da doença, passando por quadros clínicos potencialmente fatais), continua a ser um dos grandes desafios da investigação méd...

  16. Mal de Hansen, anticorpos antifosfolípides e obstrução das artérias fibulares Leprosy, antiphospholipid antibodies and bilateral fibular arteries obstruction

    Directory of Open Access Journals (Sweden)

    Liz Wallin

    2009-04-01

    Full Text Available Pacientes com Mal de Hansen (MH podem se apresentar com quadro clínico e laboratorial sugestivo de doenças reumáticas, o que exige um exercício cuidadoso de diagnósticos diferenciais. Descreve-se aqui o caso de uma jovem com MH que se apresentou com lesões cutâneas sugestivas de vasculite, obstrução de vasos fibulares, FAN e anticorpos antifosfolípides positivos sem muitos estigmas da doença cutânea, ilustrando essa dificuldade.Patients with Hansen's disease (HD may present themselves with clinical and laboratorial features that resemble rheumatic disorders. This requires a careful exercise of differential diagnosis. We describe here a case of a young woman with HD that presented with vasculitic like lesions, fibular vessels obstruction, ANA and antiphospholipid antibodies without typical signs of cutaneous disease, illustrating this clinical difficulty.

  17. Atomistic simulation of site preference, Curie temperature and lattice vibration of ZrT12−xMx (T=Fe, Co; M=Al, Ga)

    International Nuclear Information System (INIS)

    A series of lattice inversion pair potentials are used to evaluate the phase stability and site preference of ZrT12−xMx (T=Co, Fe; M=Al, Ga; x=6.0, 6.5, 7.0) compounds. The calculated preferential occupation site of the M atom is found to be the 8i site, which is in good agreement with experimental results. And the calculated lattice constants coincide quite well with experimental values. Further, the energy DOS of the relaxed structures are calculated and the variation in Curie temperature is explained qualitatively by the spin-fluctuation theory. Meanwhile, the phonon densities of states and Debye temperature are evaluated for the ZrT12−xMx compounds

  18. Teste de hemaglutinação na sorologia da malária humana empregando hemácias parasitadas pelo Plasmodium berghei

    Directory of Open Access Journals (Sweden)

    Maria Carmen Arroyo Sanchez-Ruiz

    1985-06-01

    Full Text Available Foi padronizado um teste de hemaglutinação para a sorologia da malária humana, com reagente constituído de suspensão de hemácias de camundongos infectadas pelo Plasmodium berghei e preservadas por fixação aldeídica. Em pacientes com parasitemia por P. falciparum ou P. vivax obteve-se uma sensibilidade de 98,9% nos 88 casos estudados, o teste apresentando títulos entre 40 e 640. Para o grupo de 476 soros de indivíduos não-maláricos, obteve-se uma especificidade de 96,0%. O teste apresentou elevada reprodutibilidade, mesmo para diferentes lotes de antígenos. Nos 200 soros, obtidos ao acaso, de indivíduos de área endêmica, o teste apresentou positividade de 48,5%, contra 88,0% do teste de imunofluorescência-IgG. A baixa positividade pode ser devida a que o teste de hemaglutinação detecta anticorpos IgM. Após tratamento com 2-mercaptoetanol, todos os soros de pacientes com parasitemia tornaram-se não reagentes. Em relação ao teste de imunofluorescência-IgG, o teste de hemaglutinação apresentou índice de co-positívidade de 0,989 para os soros de maláricos com parasitemia. Para os soros de não-maláricos o teste de hemaglutinação apresentou índice de co-negatividade de 0,969. Por outro lado, no grupo de soros de área endêmica, o índice de co-positividade foi de 0,528 e o de co-negatividade, de 0,833.A hemagglutination test is described for human malaria serodiagnosis with aldehyde-fixed Plasmodium berghei infected mouse erythrocytes. In patients with a P. falciparum or P. vivax patent parasitemia positive results were seen in 98.9% ofthe 88 cases tested. Titres rangedfrom 40 to 640. A 96.0% specificity wasfoundfor 476 non-malarialpatients. A close reproducibility was observed forthe test, even for dijferent reagent batches. The test was positive in 48.5% of 200 residents in malaria endemic areas, taken at random. These subjects showed 88.0% positivity of the IgG-immunofluorescence test. This lower positivity for

  19. Nanotecnologia farmacêutica aplicada ao tratamento da malária Application of pharmaceutical nanotechnology to the treatment of malaria

    OpenAIRE

    Lúcio Figueira Pimentel; Agenor Tavares Jácome Júnior; Vanessa Carla Furtado Mosqueira; Nereide Stela Santos-Magalhães

    2007-01-01

    Apesar do desenvolvimento tecnológico e científico, a malária permanece como um dos maiores problemas de saúde a serem combatidos. As estratégias modernas para o controle da doença prevêem ações conjuntas, como o combate do inseto vetor, diagnóstico rápido e preciso, garantia de terapêutica adequada, redução dos casos de resistência, além do desenvolvimento de novos agentes terapêuticos e vacina e através da otimização da ação de fármacos utilizados na atualidade. Os sistemas de liberação con...

  20. Elektronická komunikace v malém podniku s využitím ICT procesů

    OpenAIRE

    Hübel, Květoslav

    2011-01-01

    Práce se zabývá možností využití informačních a komunikačních technologií (ICT) v podmínkách a s omezeními typickými pro malé firmy s cílem zvýšení konkurenceschopnosti na trhu a efektivní týmové spolupráce v rámci společnosti. Vlastní řešení představuje návrh informační strategie servisně obchodní firmy s výhledem zavedení ERP systému.

  1. Associação entre a contagem de linfócitos T CD4+ e a gravidade da neoplasia intra-epitelial cervical diagnosticada pela histopatologia em mulheres infectadas pelo HIV Association between CD4+ T-cell count and intraepithelial cervical neoplasia diagnosed by histopathology in HIV-infected women

    Directory of Open Access Journals (Sweden)

    Juliana Barroso Zimmermmann

    2006-06-01

    Full Text Available OBJETIVO: avaliar a associação entre a contagem de linfócitos T CD4+ e a gravidade da neoplasia intra-epitelial cervical em pacientes HIV positivas. MÉTODOS: estudo transversal no qual foram incluídas 87 pacientes infectadas pelo HIV, confirmado por testes sorológicos prévios. Todas eram portadoras do HPV cervical, diagnosticado por meio da reação em cadeia da polimerase. Foram realizados anamnese, exame físico e colposcopia de todas em pacientes. A biópsia do colo uterino foi realizada quando indicada pelo exame colposcópico. Os resultados histopatológicos foram classificados com neoplasia intra-epitelial de baixo grau (NIC I ou de alto grau (NIC II e II. A associação entre a contagem de linfócitos T CD4+ e a gravidade da lesão foi verificada por meio da comparação de médias utilizando a análise da variância (ANOVA. RESULTADOS: entre as 60 pacientes biopsiadas foram encontrados 24 casos (40,0% com NIC I, oito (13,3% NIC II, três (5% NIC III, 14 (23,3% pacientes somente com cervicite crônica e 11 (18,3% apresentando efeito citopático produzido pelo HPV, mas sem perda da polaridade celular. Isso equivale a 35 mulheres com lesão intra-epitelial de baixo grau (NIC I + HPV (58,3% e 11 (18,3% com lesão intra-epitelial de alto grau (NIC II + NIC III. A associação entre a média da contagem de linfócitos T CD4+ e a gravidade da lesão intra-epitelial cervical não foi significativa (p=0,901. CONCLUSÕES: não houve associação entre a contagem de linfócitos T CD4+ e a gravidade da lesão intra-epitelial do colo uterino, diagnosticada pelo exame histopatológico.PURPOSE: to evaluate association between CD4+ cell count and cervical intraepithelial lesion severity in HIV-infected women. METHODS: cross-sectional study of 87 HIV-infected patients which were confirmed by previous serologic examinations. All had cervical HPV diagnosed by polymerase chain reaction (PCR. All patients underwent anamnesis, physical examinations and

  2. Analysis of the risk factors for incidental carcinoma of the prostate in patients with benign prostatic hyperplasia Análise dos fatores de risco para o diagnóstico do carcinoma incidental da próstata em pacientes com hiperplasia prostática benigna

    Directory of Open Access Journals (Sweden)

    Alberto Azoubel Antunes

    2006-01-01

    ática benigna. MÉTODOS: O estudo compreendeu a análise retrospectiva de 218 pacientes. Após o tratamento cirúrgico, os pacientes com achado de carcinoma incidental da próstata foram comparados com os pacientes sem este achado. As variáveis pré-operatórias analisadas foram idade, toque retal, PSA, densidade do PSA, volume prostático e biópsia prostática pré-operatória. Também foram determinados a sensibilidade, especificidade, valor preditivo positivo e valor preditivo negativo do toque retal e do PSA para o diagnóstico do carcinoma incidental da próstata. RESULTADOS: Treze (6.2% dos 218 pacientes apresentaram carcinoma incidental da próstata. Oito (61.5% deles foram classificados com T1a e 5 (38.5% como T1b. Apenas a idade avançada (p=0.003 e a presença de um toque retal suspeito (p=0.016 se relacionaram estatisticamente com este achado na peça cirúrgica. A sensibilidade, especificidade, valore preditivo positivo e negativo para o diagnóstico de carcinoma incidental da próstata foram de 23.0%, 96.6%, 30.0%, 95.2% para a presença de um toque retal suspeito e 85.0%, 34.1%, 7.5% e 97.2% para um valor de PSA maior que 4.0 ng/ml respectivamente. A exatidãos dois métodos foi de 92.2% e 37.1% respectivamente. CONCLUSÕES: A idade avançada e a presença de um toque retal suspeito representam os fatores de risco mais importantes para o diagnóstico de carcinoma incidental da próstata.

  3. 水稻内生成团泛菌YS19共质体形成差异表达蛋白MalE及其兼职功能%Symplasmata Formation Related MalE Protein and Its Moonlighting Functions in Rice Endophyte Pantoea agglomerans YS19

    Institute of Scientific and Technical Information of China (English)

    李倩倩; 熊小路; 牟昱飞; 易婷; 李二丽; 卢镇岳; 缪煜轩; 冯永君

    2012-01-01

    this protein was successfully obtained. Then, database searching with Mascot in the SWISS-Prot database was performed using the recorded peptide mass fingerprint data. It is found that among 53 peptides, there are 14 peptide masses matching to MalE from Enterobacter aerogenes, which is a protein belonging to the periplasmic maltose-binding protein family of the ATP-binding cassette transporters. Then the gene of the MalE protein was cloned from YS19, expressed in the E. Coli BL21 (DE3), and the recombinant protein was purified to homogeneity. Under stress (acid) treatments, the recombinant protein showed strong anti-aggregation ability, and even exhibited chaperone-like activity. This assay was achieved by comparing the quantity of the substrate proteins remaining in the supernatant under various denaturing acid conditions, where the aggregation of the substrate protein was effectively suppressed in the presence of the recombinant MalE protein. Far-UV circular dichroism spectroscopy examination on the purified MalE proteins under different pHs indicated that the global structures exhibited a sudden transition from a highly ordered conformation to a less ordered one. However, MalE was still capable of maintaining most of its secondary structures under these extreme acidic conditions (pHl~2). Finally, the Bis-ANS fluorescent probe technique was used to explore the effect of acid condition on the hydrophobic surfaces exposing of the protein. It is found that with the decrease of the pH value, the fluorescence intensity of the samples increased gradually, suggesting the MalE protein exposed the hydropbobic surfaces of the molecule to bind the substrates, implying the protein performed its chaperone activity via exposing its hydrophobic surfaces under acidic condition. MalE protein, originally found as a periplasmic maltose-binding protein of the ATP-binding cassette transporters, whose expression in YS19, however, far exceeds the amount being needed for transmembrane

  4. Agentes etiológicos de onicomicosis diagnosticadas en el laboratorio de micología médica de la Universidad de Costa Rica Etiological agents of onychomycosis diagnosed in the medical mycology laboratory of the University of Costa Rica

    Directory of Open Access Journals (Sweden)

    Ingrid Salas-Campos

    2012-06-01

    Full Text Available Justificación y objetivos: Entre las onicodistrofias, la onicomicosis es la afección más frecuente. Esta infección no solo representa un problema estético para el paciente, sino que puede afectar sus actividades diarias. Para el dermatólogo se hace indispensable realizar el diagnóstico diferencial, por lo que el laboratorio de micología médica es de gran ayuda para este propósito. En cuanto a los agentes etiológicos incriminados, los dermatofitos son los más frecuentes; sin embargo, otros hongos filamentosos no dermatofitos se han aislado, cuya sensibilidad a los antimicóticos es menor. En este trabajo se estudió la frecuencia de las onicomicosis diagnosticadas en el laboratorio de Micología Médica de la UCR durante cuatro años, según edad y sexo de los pacientes, así como agentes etiológicos identificados. Métodos: Se incluyó a todos los pacientes que solicitaron el servicio de acción social que brinda la sección de Micología Médica, Facultad de Microbiología, Universidad de Costa Rica, entre enero del 2007 a diciembre del 2010 y que presentaban alteraciones ungueales sospechosas de onicomicosis. Se registró la edad y sexo de los pacientes y las muestras se procesaron por examen directo y cultivo. Resultados: Se procesaron 431 muestras de uñas, el 85,4% eran de pie y el 14,6% de mano, la edad promedio de los pacientes fue de 49 años, el 64% eran mujeres y el 36% eran hombres. En el 73,4% se diagnosticó onicomicosis, ya sea por examen directo positivo y cultivo positivo, o solo con el examen directo, de las cuales 89,4% eran uñas de pie y 10,6% uñas de manos. De las uñas de los pies se aisló más frecuentemente Trichophyton rubrum y en segundo lugar Fusarium spp. En uñas de manos C. albicans fue el agente etiológico más frecuente. Conclusión: En el diagnóstico de las onicomicosis se debe considerar tanto la clínica como los hallazgos de laboratorio. En la población estudiada se identificaron dermatofitos

  5. Q-values of the Superallowed beta-Emitters 26m-Al, 42-Sc and 46-V and their impact on V_ud and the Unitarity of the CKM Matrix

    CERN Document Server

    Eronen, T; Elomaa, V; Hager, U; Hakala, J; Jokinen, A; Kankainen, A; Kolhinen, V S; Moore, I; Pentillä, H; Rahaman, S; Rissanen, J; Saastamoinen, A; Sonoda, T; Äystö, J

    2006-01-01

    The beta-decay Q_EC-values of the superallowed beta emitters 26m-Al, 42-Sc and 46-V have been measured with a Penning trap to a relative precision of better than 8x10^-9. Our result for 46-V, 7052.72(31) keV, confirms a recent measurement that differed significantly from the previously accepted reaction-based Q_EC-value. However, our results for 26m-Al and 42-Sc, 4232.83(13) keV and 6426.13(21) keV, are consistent with previous reaction-based values. By eliminating the possibility of a systematic difference between the two techniques, this result demonstrates that no significant shift in the deduced value of V_ud should be anticipated.

  6. Influência da malária assintomática em parâmetros de crescimento e desenvolvimento em crianças e jovens de uma região rural de Moçambique

    OpenAIRE

    Domingos Madeira, Aspácia

    2011-01-01

    Moçambic registra una alta prevalença de malària amb un elevat índex de parasitèmia assintomàtica, però no hi ha estudis coneguts sobre la seva relació amb els diferents components del desenvolupament humà. L’objectiu va ser estudiar les característiques de creixement i desenvolupament dels nens, nenes i adolescents amb malària assintomàtica de les zones rurals de Calanga. L’estudi, de caràcter retrospectiu, es va portar a terme en una mostra de 351 subjectes d’ambdós, dividits en grups de 5...

  7. Problémy vyplývající z rozdílů české účetní legislativy a IFRS pro malé a střední podniky

    OpenAIRE

    Pazourková, Radka

    2011-01-01

    Předmětem diplomové práce je definovat rozdíly ve vykazování účetních informací podle českých účetních předpisů, podle standardního souboru IFRS a dle IFRS pro malé a střední podniky a vyčíslení nákladů a vymezení přínosů přechodu na vykazování účetních informací dle IFRS pro malé a střední podniky. Object of the thesis is to define differences in financial reporting according to the Czech Accounting Standards and to the standard file International Financial Reporting Standards and to the ...

  8. Alterações clínicolaboratoriais em pacientes com malária por Plasmodium vivax e deficiência de glicose-6-fosfato desidrogenase tratados com 0,50mg/kg/dia de primaquina

    OpenAIRE

    Silva Mônica C.M.; Santos Eliane B.; Costa Elenild G.; S. Filho Manoel G.; Guerreiro João F.; Póvoa Marinete M

    2004-01-01

    O efeito adverso da primaquina na dose de 0,50mg/kg/dia foi investigado em onze pacientes com malária vivax (três com deficiência de glicose-6-fosfato desidrogenase). Alterações clínicas e laboratoriais indicaram hemólise aguda apenas nos enzimopênicos, o que fez com que o tratamento fosse interrompido. Nossos resultados sugerem a necessidade do emprego de um teste de triagem para a deficiência de G6PD em áreas endêmicas de malária vivax a fim de se evitar complicações causadas pelo uso da pr...

  9. Spectroscopic Properties of Novel Aromatic Metal Clusters: NaM4 (M=Al, Ga, In) and their Cations and Anions

    Energy Technology Data Exchange (ETDEWEB)

    Balasubramanian, K; Zhao, C

    2004-03-17

    The ground and several excited states of metal aromatic clusters, namely NaM4 and NaM{sub 4}{sup {+-}} (M=Al, Ga, In) clusters have been investigated by employing complete activespace self-consistent-field (CASSCF) followed by Multi-reference singles and doubles configuration interaction (MRSDCI) computations that included up to 10 million configurations and other methods. The ground states NaM{sub 4}{sup -} of aromatic anions are found to be symmetric C{sub 4v} ({sup 1}A{sub 1}) electronic states with ideal square pyramid geometries. While the ground state of NaIn4 is also predicted to be a symmetric C{sub 4v} ({sup 2}A{sub 1}) square pyramid, the ground state of the NaAl4 cluster is found to have a C{sub 2v} ({sup 2}A{sub 1}) pyramid with a rhombus base and the ground state of NaGa{sub 4} possesses a C{sub 2v} ({sup 2}A{sub 1}) pyramid with a rectangle base. In general these structures exhibit 2 competing geometries, viz., an ideal C{sub 4v} structure and a distorted rhomboidal or rectangular pyramid structure (C{sub 2v}). All of the ground states of the NaM{sub 4}{sup +} (M= Al, Ga, In) cations are computed to be C{sub 2v} ({sup 3}A{sub 2}) pyramids with rhombus bases. The equilibrium geometries, vibrational frequencies, dissociation energies, adiabatic ionization potentials, adiabatic electron affinities for the electronic states of NaM{sub 4} (M=Al, Ga, In) and their ions are computed and compared with experimental results and other theoretical calculations. On the basis of our computed excited states energy separations, we have tentatively suggested assignments to the observed X and A states in the anion photoelectron spectra of Al{sub 4}Na{sup -} reported by Li et al. The X state can be assigned to a C{sub 2v} ({sup 2}A{sub 1}) rhomboidal pyramid. The A state observed in the anion spectrum is assigned to the first excited state ({sup 2}B{sub 1}) of the neutral NaAl{sub 4} with the C{sub 4v} symmetry. The assignments of the excited states are consistent with

  10. Réflexion autour de la banalité du mal inspirée d’une conversation avec Jean-Paul Brodeur

    Directory of Open Access Journals (Sweden)

    Samuel Tanner

    2012-05-01

    Full Text Available Si la notoriété de Jean-Paul Brodeur est en grande partie due à ses recherches sur la police, il est un autre domaine, plus méconnu du grand public, qui le passionnait et le fascinait, à savoir les formes extrêmes de violence, dont le génocide et le crime contre l’humanité. Dans le cadre de cet article, je prolonge un dialogue que nous avions entamé avec Jean-Paul à propos du concept de banalité du mal, développé par Hannah Arendt. En particulier et à partir des contextes yougoslave et rwandais, je propose une extension de cette notion appliquée non pas tant ici aux fonctionnaires et bureaucrates, tels qu’ils constituaient le centre d’attention de la philosophie, alors concentrée sur l’Holocauste, mais bien plutôt des exécuteurs de terrain. Cette réflexion préliminaire révèle que la notion de banalité du mal peut être déclinée en quatre formes caractérisant la participation des exécuteurs ; soit la banalité de la similitude, de la familiarité, de l’idée et enfin de répétition.If Jean-Paul Brodeur’s notoriety was mostly due to his work on police, his fascination for another field, namely extreme forms of violence like genocide and crimes against humanity, remained less known form the public. This article is an extension of a dialogue Jean-Paul and I had on the concept of banality of evil, such as developed by Hannah Arendt. In particular, and based on the Yugoslav and Rwandan contexts, I suggest an expansion of the concept’s application, yet this time not so much on civil servants and bureaucrats, who constituted Arendt’s center of interest while focusing on the Holocaust, but rather on field executioners. This preliminary insight reveals that the notion of banality of evil might be disaggregated into four subcategories that characterize executioners’ participation in mass violence, namely a banality of similitude, of familiarity, of idea and of repetition.

  11. Flashback. El tiempo de los gitanos (Kusturica). Quieto, muere, resucita (Kanevski). Boom, Boom (R. Vergés). Henry, retrato de un asesino (Me Naugthon). La vida privada de Sherlock Holmes (B. Wilder). Sed de mal (Welles)

    OpenAIRE

    Nogueira, Xosé; Alonso Quintás, Enrique; Arias, Dany

    1992-01-01

    Nogueira, X.; Alonso Quintás, E.; Arias, D. (1992). Flashback. El tiempo de los gitanos (Kusturica). Quieto, muere, resucita (Kanevski). Boom, Boom (R. Vergés). Henry, retrato de un asesino (Me Naugthon). La vida privada de Sherlock Holmes (B. Wilder). Sed de mal (Welles). Vértigo. Revista de cine. (2):3-8. http://hdl.handle.net/10251/42914. 3 8 2

  12. Geochemistry of amphibolites and related graphitic gneisses from the Suchý and Malá Magura Mountains (central Western Carpathians – evidence for relics of the Variscan ophiolite complex

    Directory of Open Access Journals (Sweden)

    Ivan Peter

    2015-10-01

    Full Text Available Three small bodies of amphibolites and associated graphitic gneisses from the Suchý and Malá Magura Mountains (Tatric Megaunit, central Western Carpathians have been studied by petrographic and geochemical methods. Isolated, fault-bounded bodies first hundreds of meters in size are located in the complex of the Early Paleozoic paragneisses and migmatites intruded by the Lower Carboniferous granitoid rocks. Amphibolites (locally actinolite schists were formed from effusive basalts, dolerites or isotropic gabbros hydrothermally altered and veined before the regional metamorphic transformation. Distribution of the trace elements relatively immobile during the metamorphic alteration (HFSE, REE, Cr, V, Sc is similar to E-MORB type in the Malá Magura Mountain or to N-MORB/E-MORB types in the Suchý Mountain. Graphitic gneisses to metacherts are rich in silica (up to 88 wt. % and Ctot, poor in other major element contents and display negative Ce-anomaly, enrichment in HREE, V, Cr and U. They were probably originally deposited as non-carbonate and silica-rich deep-sea sediments in anoxic conditions. The oceanic provenance of amphibolites and related graphitic gneisses clearly indicates their oceanic crust affinity and identity with the uppermost part of the ophiolite sequence. Ophiolite bodies from the Suchý and Malá Magura Mountains are supposed to be relic fault blocks identical with the Upper Devonian Pernek Group which represents a Variscan ophiolite nappe preserved to large extent in the Malé Karpaty Mountains located in the Tatric Megaunit further to the southwest. All these ophiolite relics are vestiges of the original ophiolite suture created by oceanic closure in the Lower Carboniferous.

  13. Malaria diagnosis and treatment under the strategy of the integrated management of childhood illness (IMCI): relevance of laboratory support from the rapid immunochromatographic tests of ICT Malaria P.f/P.v and OptiMal

    DEFF Research Database (Denmark)

    Tarimo, D S; Minjas, J N; Bygbjerg, I C

    2001-01-01

    The algorithm developed for the integrated management of childhood illness (IMCI) provides guidelines for the treatment of paediatric malaria. In areas where malaria is endemic, for example, the IMCI strategy may indicate that children who present with fever, a recent history of fever and/or pallor...... and by using two rapid immunochromatographic tests (RIT) for the diagnosis of malaria (ICT Malaria P.f/P.v and OptiMal. At the time they were tested, each of these children had been targeted for antimalarial treatment (following the IMCI strategy) because of fever and/or pallor. Only 70% of the 395...... sensitivity of 93.0% and a specificity of 15.5% whereas pallor had a sensitivity of 72.2% and a specificity of 50.8%. The RIT both had very high corresponding sensitivities (of 100.0% for the ICT and 94.0% for OptiMal) but the specificity of the ICT (74.0%) was significantly lower than that for OptiMal (100...

  14. Caminhos de um mal-estar de civilização: reflexões intelectuais norte-americanas para pensar a democracia e o negro no Brasil

    Directory of Open Access Journals (Sweden)

    Elizabeth Cancelli

    2010-05-01

    Full Text Available

    Este trabalho tem como objetivo buscar eixos de reflexão desenvolvidos nos Estados Unidos e que foram importantes para repensar a questão da democracia e da cultura no Brasil, especialmente no que diz respeito à inclusão social do negro e à construção de uma identidade brasileira. Assim, as releituras da herança da escravidão verificadas no Sul norte-americano nas primeiras décadas do século XX e o encorajamento para a redefinição da democracia, ocorridos no auge da guerra fria e da cultural war, serão contemplados para a recuperação de vertentes importantes do pensamento brasileiro e sua inserção nos debates em torno desse “mal-estar de civilização”.

  15. Filosofía del mal y memoria, de Alejandro Forero Cuellar, Iñaki Rivera Beiras, Héctor Silveira Gorski

    Directory of Open Access Journals (Sweden)

    Sebastián Cabezas Chamorro

    2012-09-01

    Full Text Available La obra que aquí se comenta, es el producto de la sociedad formada entre el Observatori del Sistema Penal i els Drets Humans de la Universitat de Barcelona (OSPDH, el Máster oficial de Criminología y Sociología Jurídico-Penal de la misma casa de estudios y la editorial Anthropos-Siglo XXI.Precisamente en el marco de las actividades del OSPDH, en invierno del año 2010 se realizó el seminario “Filosofía del Mal y Memoria”. En dicha oportunidad participaron como ponentes Roberto Bergalli, Sebastian Scheerer, Manuel Reyes Mate y Luigi Ferrajoli, cuyas exposiciones son revisadas en esta obra. Importante es destacar que esta obra está compuesta no sólo por las disertaciones de ellos, sino que también por las intervenciones en el debate de los participantes del seminario; de ahí que este trabajo sea la reproducción exacta de todo lo allí sucedido, lo cual en definitiva explica, la profundidad y la riqueza de su contenido, más allá de la brevedad del texto. 

  16. Pembuatan Strategic Dashboard untuk Mengidentifikasi dan Mengukur Potensi Tingkat Kesehatan Lembaga Keuangan Syariah Baitul Mal Wat Tamwil (BMT dengan Metode PEARLS Studi Kasus APEX

    Directory of Open Access Journals (Sweden)

    Jeanny Mareta Daud

    2012-09-01

    Full Text Available BMT (Baitul Mal Wat Tamwil tidak diakui sebagai non-bank lembaga keuangan, pada prinsipnya, lembaga BMT harus berfungsi sebagai lembaga intermediasi yang mengelola dana dari, untuk dan oleh masyarakat. BMT mencakup konsep pembiayaan kredit keuangan, jasa, asuransi simpananserta bagi masyarakat miskin dalam kegiatan ekonomi dan Pemerintah subsisten. Idealnya dengan mengintegrasikan konsep fungsi sosial, fungsi bisnis dalam satu wadah telah didirikan lembaga-lembaga penegakan hukum di lembaga-lembaga keuangan mikro syariah. APEX adalah lapis kedua (kedua lembaga tier atau organisasi yang mendistribusikan dana (baik dari hibah, pinjaman atau jaminan yang berperan untuk melayani anggota melalui sistem Informasi dan Komunikasi (TIK yang terintegrasi dalam lingkup nasional. APEX menjadi permukiman dan badan hukum akan mengetahui dan menganalisis kesehatan setiap anggota BMT. Pada dasarnya kesehatan penilaian diciptakan oleh World Council of serikat kredit (WOCCU adalah Mutiara (Perlindungan, Efektif, Aset, Tingkat pengembalian dan biaya, Likuiditas dan Tanda pertumbuhan. Hasil telah dilakukan dengan pembuatan aplikasi PEARLS dan pembuatan Dashboard PEARLS memudahkan pihak Executive untuk mengidentifikasi dan mengukur potensi tingkat kesehatan LKMS BMT secara strategis dan efektif dengan  menggunkanan metode PEARLS.

  17. Počítačový návrh malého televizního kabelového rozvodu

    OpenAIRE

    Sedláček, Jan

    2008-01-01

    Hlavním úkolem této bakalářské práce je vytvořit interaktivního počítačového programu pro návrh obvodů individuální nebo malé společné televizní antény. První část práce popisuje hlavní koncepce rozvodu televizního signálu, parametry koaxiálního kabelu a také některé typy zkreslení signálu. Je zde popsáno několik důležitých vztahů použitých pro výpočet útlumu koaxiálního kabelu a odstupu signálu od šumu a tedy důležitých i pro výpočetní funkci programu. Druhá část popisuje postup návrhu telev...

  18. Návrh využití nástrojů Business Intelligence pro potřeby malé firmy

    OpenAIRE

    Stryka, Lukáš

    2008-01-01

    Tato diplomová práce se zabývá analýzou stávajících procesů probíhajících v malé softwarové firmě. Na základě vyhodnocení slabých stránek jsou navržena rozšíření informačního systému o nový modul pro on-line prodej produktů s možností okamžité bezhotovostní online úhrady. Dále je navrženo rozšíření informačního systému o nástroje Business Intelligence, které by měli pomoci zefektivnit marketingové strategie této firmy. This Diploma Thesis deals with analysis of the current processes in sma...

  19. Implementace Business Intelligence v malé a střední firmě ? JOLLY Trading s.r.o.

    OpenAIRE

    Hájek, Vojtěch

    2005-01-01

    Cílem této práce je analyzovat nasazení Business Intelligence (BI) v malých a středních podnicích (SME), určit specifika, která jsou spojena s implementací v takovéto společnosti a na základě praktického průzkumu zhodnotit, které důležité faktory ovlivňují nasazení BI systémů v těchto společnostech. Pro dosažení cíle bylo provedeno dotazníkové šetření, kterému předcházelo shromažďování a studium materiálů z různých zdrojů. Výsledky byly následně ověřeny na praktickém projektu implementace ve ...

  20. Simulace malé větrné elektrárny se Savoniovým-Darrieovým rotorem

    OpenAIRE

    Hořava, Pavel

    2014-01-01

    Tato diplomová práce se zabývá simulací malé větrné elektrárny se Savoniovým-Darrieovým rotorem. V teoretické části je na základě teorie, kterou vytvořil německý fyzik Albert Betz, odvozen výkon modelované elektrárny a také činitel výkonu. V této části je také podrobně popsán postup návrhu modelu větru. Praktická část práce je pak zaměřena na vytvoření samotného modelu hybridní větrné elektrárny s vertikální osou otáčení DS300, přičemž pro modelování je zvolen Matlab/Simulink. Pomocí tohoto m...

  1. Návrh malé větrné elektrárny se Savoniovým rotorem

    OpenAIRE

    Foltýn, Petr

    2009-01-01

    Tato bakalářská práce se zabývá návrhem konstrukčního řešení větrné elektrárny se Savoniovým rotorem. V první části je souhrn teoretických poznatků, které mají vést k optimální konstrukci větrného energetického zdroje. V druhé části je vypracován konkrétní návrh malé větrné elektrárny včetně 3D modelu a konstrukčních výkresů zpracovaných v programu Autodesk Inventor Professional 2009. This Bachelor’s thesis deals with proposal of constructional solving of wind turbine system with Savonius ...

  2. In vivo subcellular localization of Mal de Rio Cuarto virus (MRCV) non-structural proteins in insect cells reveals their putative functions

    Energy Technology Data Exchange (ETDEWEB)

    Maroniche, Guillermo A.; Mongelli, Vanesa C.; Llauger, Gabriela; Alfonso, Victoria; Taboga, Oscar [Instituto de Biotecnologia, CICVyA, Instituto Nacional de Tecnologia Agropecuaria (IB-INTA), Las cabanas y Los Reseros s/n. Hurlingham Cp 1686, Buenos Aires (Argentina); Vas, Mariana del, E-mail: mdelvas@cnia.inta.gov.ar [Instituto de Biotecnologia, CICVyA, Instituto Nacional de Tecnologia Agropecuaria (IB-INTA), Las cabanas y Los Reseros s/n. Hurlingham Cp 1686, Buenos Aires (Argentina)

    2012-09-01

    The in vivo subcellular localization of Mal de Rio Cuarto virus (MRCV, Fijivirus, Reoviridae) non-structural proteins fused to GFP was analyzed by confocal microscopy. P5-1 showed a cytoplasmic vesicular-like distribution that was lost upon deleting its PDZ binding TKF motif, suggesting that P5-1 interacts with cellular PDZ proteins. P5-2 located at the nucleus and its nuclear import was affected by the deletion of its basic C-termini. P7-1 and P7-2 also entered the nucleus and therefore, along with P5-2, could function as regulators of host gene expression. P6 located in the cytoplasm and in perinuclear cloud-like inclusions, was driven to P9-1 viroplasm-like structures and co-localized with P7-2, P10 and {alpha}-tubulin, suggesting its involvement in viroplasm formation and viral intracellular movement. Finally, P9-2 was N-glycosylated and located at the plasma membrane in association with filopodia-like protrusions containing actin, suggesting a possible role in virus cell-to-cell movement and spread.

  3. Transmisión del Mal de Río Cuarto virus por ninfas de primer y tercer estadio de Delphacodes kuscheli Transmission of Mal de Río Cuarto virus by first and third-instar nymphs of Delphacodes kuscheli

    Directory of Open Access Journals (Sweden)

    Joel Arneodo

    2005-02-01

    Full Text Available Se comparó la capacidad de ninfas de primer y tercer estadío de Delphacodes kuscheli Fennah (Hemiptera: Delphacidae para adquirir y posteriormente transmitir el Mal de Río Cuarto virus (MRCV, bajo condiciones controladas. Ninfas I y III avirulíferas se alimentaron separadamente de plantas de trigo infectadas durante 48 horas, para luego ser colocadas en subgrupos de tres individuos sobre plantas de trigo sanas. Se realizaron transmisiones seriales utilizando períodos de inoculación de 24 horas. Ambos estadií os lograron adquirir y transmitir el MRCV, pero se evidenció una mayor cantidad de subgrupos infectivos cuando la adquisición se efectuó como ninfas I, así como una disminución significativa en la duración del período de latencia del virus respecto de los insectos que adquirieron el MRCV durante el tercer estadio ninfal.The ability of first and third-instar Delphacodes kuscheli Fennah (Hemiptera: Delphacidae nymphs to acquire and transmit Mal de Río Cuarto virus (MRCV, under controlled conditions, was investigated. First and third-instar nymphs were allowed acquisition feeding separately on infected wheat plants for 48 hours. The insects were then placed in groups of three for serial transmissions to healthy wheat plants, using inoculation periods of 24 hours. Both instars of D. kuscheli were demonstrated to acquire and subsequently transmit the virus. Nevertheless, transmission trials showed highest transmission efficiency and shortest latent period when MRCV was acquired by first-instar nymphs.

  4. Heterogeneity of malaria prevalence in alluvial gold mining areas in Northern Mato Grosso State, Brazil Heterogeneidade da prevalência de malária em garimpos do norte de Mato Grosso, Brasil

    Directory of Open Access Journals (Sweden)

    Alisson Flávio Barbieri

    2007-12-01

    Full Text Available This paper analyzes factors affecting the risk of malaria among individuals working in wildcat gold mining camps (garimpos in northern Mato Grosso State in the Brazilian Amazon. Historically, such mining camps have the locations with the highest malaria prevalence in the Brazilian Amazon. However, little attention has focused on understanding the disease from the internal perspective of the mining camps themselves, such as the mining population's characteristics and its spatial organization. This paper adopts a stepwise logistic model to identify spatial, occupational-exposure, and cultural factors that affect malaria prevalence. According to the results, differences among individuals working and/or living in the gold mining areas could produce different exposure to the disease and thus to different risk of malaria prevalence. Understanding these differences may provide an important tool for identifying risk profiles in the gold mining and related population and for informing programs for prevention and treatment of malaria in the Amazon.O artigo analisa fatores que afetam o risco de malária entre garimpeiros de ouro no norte de Mato Grosso, Brasil. Historicamente, os garimpos apresentam a maior prevalência de malária da Amazônia Legal brasileira. Entretanto, até o momento houve pouca investigação no sentido de compreender a doença desde a perspectiva interna dos próprios garimpos, ou seja, através das características da população garimpeira e da sua organização espacial. O artigo adota um modelo logístico stepwise para identificar fatores territoriais, culturais e de exposição ocupacional que afetam a prevalência da malária. Com base nos resultados, diferenças entre indivíduos que trabalham e/ou vivem nas áreas de garimpo poderiam produzir variações na exposição à doença, levando a um risco diferenciado de prevalência de malária. A compreensão dessas diferenças pode representar uma ferramenta importante para

  5. Are calcium and fiber beneficial for poorly controlled diabetic patients? ¿Son calcio y fibras beneficiosos para pacientes diabéticos mal controlados?

    Directory of Open Access Journals (Sweden)

    D. A. R. Matos

    2011-04-01

    Full Text Available No nutritional protocol for poorly controlled diabetic patients receiving well-managed drug treatment is currently available. Objective: Aims were to compare dietary consumption of calcium and fibers with lipid profile and glycosilated hemoglobin HbA1c. Methodology: This was a prospective observational study. Patients with poorly controlled diabetes were consecutively recruited. A food-frequency questionnaire and tests for lipid profile, HbA1c, and C reactive protein were collected, along with clinical and anthropometric assessment. Results: Patients (N = 114, age 65.7 ± 6.5 years, 75.4% females, BMI 29.0 ± 5.3 kg/m² were often insulin-dependent (32.5% and with systemic inflammation (C-reactive protein 4.2 ± 3.9 mg/L. Diet was energy restricted (1,365 ± 565 kcal/day and mostly adequate but with suboptimal fiber (15.4 ± 8.6 g/day and very low calcium (592.4 ± 204.4 mg/day. Calcium and fiber in the diet correlated with serum lipids, whereas fiber alone displayed a protective association regarding diabetes (HBA1c, insulin use and arterial hypertension. Conclusions: Calcium and fiber ingestion exhibited correlations with important markers of metabolic status and cardiovascular risk. Future studies should address enhancement of these ingredients by means of dietary changes and supplements.Ningún protocolo nutricional es presentemente disponible para pacientes diabéticos mal controlados recibindo terapia farmacológica bien estructurada. Objetivo: Una comparación entre consumo dietético de cálcio y fibras, y concentraciones de lípidos y hemoglobina glicosilada HbA1c fue efectuada. Metodología: Este fue un estúdio prospectivo observacional. Pacientes con diabetes mal controlada fueron consecutivamente recrutados. Las variables fueron cuestionário de frecuéncia alimentária, evaluación clínica y antropométrica, y valores séricos de lípidos, HbA1c, proteina C reactiva (PCR. Resultados: Los pacientes (N = 114, edad 65,7 ± 6,5 a

  6. Malófagos (Phthiraptera, Amblycera, Ischnocera em aves cativas no sudeste do Brasil Chewing lice (Phthiraptera, Amblycera, Ischnocera on captive birds in southeastern Brazil

    Directory of Open Access Journals (Sweden)

    Salete Oliveira da Silva

    2009-01-01

    Full Text Available Foram identificadas 12 espécies de malófagos no Parque Zoológico Municipal Quinzinho de Barros, Sorocaba e Fundação Jardim Zoológico, Rio de Janeiro. Ciconiphilus pectiniventris em Cygnus atratus (Anseriformes, Anatidae; Kurodaia sp. em Buteo albicaudatus (Falconiformes, Accipitridae; Degeeriella sp. em Falco sparverius (Falconiformes, Falconidae; Colpocephalum sp. e Goniocotes parviceps em Pavo cristatus (Galliformes, Phasianidae; Goniodes pavonis em Rhea americana (Rheiformes, Rheidae; Colpocephalum cristatae e Heptapsogaster sp. em Cariama cristata (Gruiformes, Cariamidae; Austrophilopterus cancellosus em Ramphastos dicolorus (Piciformes, Ramphastidae; Strigiphilus crucigerus em Otus choliba (Strigiformes, Strigidae; Kurodaia sp. em Rhinoptynx clamator (Strigiformes, Strigidae e Colpocephalum pectinatum em Speotyto cunicularia (Strigiformes, Strigidae. As relações parasito hospedeiros em Strigiformes são novas no Brasil.Twelve chewing lice species were identified in Parque Zoológico Municipal Quinzinho de Barros, Sorocaba and Fundação Jardim Zoológico, Rio de Janeiro. The parasites found were: Ciconiphilus pectiniventris in Cygnus atratus (Anseriformes, Anatidae; Kurodaia sp. in Buteo albicaudatus (Falconiformes, Accipitridae; Degeeriella sp. in Falco sparverius (Falconiformes, Falconidae; Colpocephalum sp. and Goniocotes parviceps in Pavo cristatus (Galliformes, Phasianidae; Goniodes pavonis in Rhea americana (Rheiformes, Rheidae; Colpocephalum cristatae and Heptapsogaster sp. in Cariama cristata (Gruiformes, Cariamidae; Austrophilopterus cancellosus in Ramphastos dicolorus (Piciformes, Ramphastidae; Strigiphilus crucigerus in Otus choliba (Strigiformes, Strigidae; Kurodaia sp. in Rhinoptynx clamator (Strigiformes, Strigidae and Colpocephalum pectinatum in Speotyto cunicularia (Strigiformes, Strigidae. The host-lice relationships are new in Strigiformes in Brazil.

  7. Ajuste rápido de dosis de tapentadol en el tratamiento del dolor mal controlado Fast titration of tapentadol for the treatment of badly controlled pain

    Directory of Open Access Journals (Sweden)

    M. J. Sánchez del Águila

    2012-02-01

    Full Text Available Introducción: el tapentadol es un nuevo fármaco de acción dual MOR/NRI, que actúa a nivel central, efectivo en el tratamiento del dolor moderado e intenso, que presenta un perfil de tolerabilidad mas favorable que otros opiáceos. Esto podría permitir una titulación rápida que permita un control precoz del dolor. Material y métodos: presentamos dos casos clínicos en los que se realiza una titulación rápida de la dosis de tapentadol en pacientes hospitalizados con dolor mal controlado. Este ajuste rápido, permitió controlar el dolor, en ausencia de efectos secundarios, acortando el tiempo de estancia hospitalaria de estos pacientes. Conclusiones: el perfil favorable de efectos secundarios mostrado por el tapentadol, permite un ajuste rápido de la dosis, que consigue un control eficaz del dolor en un menor lapso de tiempo.Background: tapentadol is a new drug with a centrally acting, dual action mechanism on MOR/NRI. It is effective on moderate to severe pain and shows a favourable side effects profile in comparison to other major opiates. This could allow a fast dose titration to achieve an earlier pain control. Material and methods: we present two cases on which we have performed a fast dose titration in hospitalised patients with bad pain control. This fast titration allowed an early control of the pain, in absence of side effects, achieving a shortening in their hospital stay. Conclusions: the favourable side effects profile of tapentadol, allows a fast dose titration, achieving an efficacious pain control in a shorter time lapse.

  8. Reorganization of the actin cytoskeleton via transcriptional regulation of cytoskeletal/focal adhesion genes by myocardin-related transcription factors (MRTFs/MAL/MKLs)

    International Nuclear Information System (INIS)

    RhoA is a crucial regulator of stress fiber and focal adhesion formation through the activation of actin nucleation and polymerization. It also regulates the nuclear translocation of myocardin-related transcription factor-A and -B (MRTF-A/B, MAL or MKL 1/2), which are co-activators of serum response factor (SRF). In dominant-negative MRTF-A (DN-MRTF-A)-expressing NIH 3T3 cell lines, the expressions of several cytoskeletal/focal adhesion genes were down-regulated, and the formation of stress fiber and focal adhesion was severely diminished. MRTF-A/B-knockdown cells also exhibited such cytoskeletal defects. In reporter assays, both RhoA and MRTF-A enhanced promoter activities of these genes in a CArG-box-dependent manner, and DN-MRTF-A inhibited the RhoA-mediated activation of these promoters. In dominant-negative RhoA (RhoA-N19)-expressing NIH 3T3 cell lines, the nuclear translocation of MRTF-A/B was predominantly prevented, resulting in the reduced expression of cytoskeletal/focal adhesion proteins. Further, constitutive-active MRTF-A/B increased the expression of endogenous cytoskeletal/focal adhesion proteins, and thereby rescued the defective phenotype of stress fibers and focal adhesions in RhoA-N19 expressing cells. These results indicate that MRTF-A/B act as pivotal mediators of stress fiber and focal adhesion formation via the transcriptional regulation of a subset of cytoskeletal/focal adhesion genes

  9. Instrumentação anterior da coluna em espondilite tuberculosa mal de pott: Relato de caso Anterior instrumentation in tuberculous spondylitis (Pott's disease: case report

    Directory of Open Access Journals (Sweden)

    Luciano Farage

    2002-03-01

    Full Text Available Relatamos caso de tratamento cirúrgico com instrumentação anterior em espondilite tuberculosa (mal de Pott, em mulher de 71 anos, que se encontrava em tratamento para tuberculose na forma pulmonar e evoluiu com dor lombar, dificuldade progressiva para deambular, cifose e disfunção vesical. A ressonância magnética revelou lesão nos corpos vertebrais de T12 e L1 com abcesso paravertebral. A paciente foi tratada cirurgicamente por acesso tóraco-abdominal lateral. Os corpos vertebrais foram ressecados, foi instalado uma gaiola vertical (mesh cage e a coluna foi estabilizada com placa lateral (Z plate e parafusos fixados em T11 e L2. Essa técnica permite boa artrodese dos corpos vertebrais remanescentes e boa estabilidade da coluna, sem comprometer a eficácia dos tuberculostáticos. A paciente foi avaliada um ano após a operação e não apresentava déficit motor, dor residual e a cifose foi desfeita.We report a case of a surgical treatment with anterior instrumentation in tuberculous spondylitis (Pott's disease, in a 71 years old woman, that was in treatment for pulmonary tuberculosis, with lumbar pain, progressive disability to walk, kyphotic deformit and vesical dysfunction. Magnetic resonance image presents a lesion in the bodies of T12 and L1, with paravertebral abscess. The patient was treated surgically by transthoracic-abdominal approach. The vertebral bodies were cut off and the spine were instrumented anteriorly with a mesh cage and a Z plate. This procedure permits a good arthrodesis and a immediately stabilization of the spine, without any complication of the infection. The patient was seen a year after the surgery and is free of infection, without motor deficit, pain or reminiscent kyphosis.

  10. Parafusos pediculares mal posicionados pela técnica freehand: qual o real valor para o surgimento de lesões neurológicas?

    Directory of Open Access Journals (Sweden)

    Marina Hirschle Galindo

    2013-12-01

    Full Text Available OBJETIVO: Verificar a existência de lesões neurológicas nos pacientes submetidos à instrumentação com parafusos pediculares mal posicionados na região toracolombar. MÉTODOS: Estudo prospectivo com seleção randômica de 30 pacientes submetidos à instrumentação pedicular por via posterior, pela técnica freehand. Foi avaliada comparativamente, de forma cega, a adequação do posicionamento dos parafusos nas vértebras por meio de tomografias. A seguir, tentou-se correlacionar a existência de alterações neurológicas relacionadas ao posicionamento dos implantes. RESULTADOS: Observados 223 parafusos pediculares na coluna toracolombar em 30 pacientes operados no serviço por diversas doenças. Houve violação da parede do pedículo vertebral em 33% dos pacientes, sendo mais da metade com invasão da cortical medial. A piora neurológica no pós-operatório imediato ocorreu em três pacientes, entretanto apenas um parafuso precisou de reposicionamento. Todos os pacientes recuperaram a situação neurológica pré-cirúrgica. CONCLUSÕES: O índice de violação cortical com parafusos pediculares mostrou-se elevado. Contudo, nota-se que pequenas violações pediculares podem causar danos neurológicos e que, quando esses acontecem, são reversíveis se o erro for corrigido.

  11. Interpenetration of a 3D Icosahedral M@Ni12 (M=Al, Ga) Framework with Porphyrin-Reminiscent Boron Layers in MNi9 B8.

    Science.gov (United States)

    Zheng, Qiang; Wagner, Frank R; Ormeci, Alim; Prots, Yurii; Burkhardt, Ulrich; Schmidt, Marcus; Schnelle, Walter; Grin, Yuri; Leithe-Jasper, Andreas

    2015-11-01

    Two ternary borides MNi9 B8 (M=Al, Ga) were synthesized by thermal treatment of mixtures of the elements. Single-crystal X-ray diffraction data reveal AlNi9 B8 and GaNi9 B8 crystallizing in a new type of structure within the space group Cmcm and the lattice parameters a=7.0896(3) Å, b=8.1181(3) Å, c=10.6497(4) Å and a=7.0897(5) Å, b=8.1579(4) Å, c=10.6648(7) Å, respectively. The boron atoms build up two-dimensional layers, which consist of puckered [B16 ] rings with two tailing B atoms, whereas the M atoms reside in distorted vertices-condensed [Ni12 ] icosahedra, which form a three-dimensional framework interpenetrated by boron porphyrin-reminiscent layers. An unusual local arrangement resembling a giant metallo-porphyrin entity is formed by the [B16 ] rings, which, due to their large annular size of approximately 8 Å, chelate four of the twelve icosahedral Ni atoms. An analysis of the chemical bonding by means of the electron localizability approach reveals strong covalent B-B interactions and weak Ni-Ni interactions. Multi-center dative B-Ni interaction occurs between the Al-Ni framework and the boron layers. In agreement with the chemical bonding analysis and band structure calculations, AlNi9 B8 is a Pauli-paramagnetic metal. PMID:26418894

  12. Estudo comparativo não randomizado do midazolam versus thiopental em crianças com estado de mal epiléptico refratário

    Directory of Open Access Journals (Sweden)

    LÖHR JUNIOR ALFREDO

    2000-01-01

    Full Text Available Avaliamos o uso do midazolam em relação ao thiopental em crianças com estado de mal epiléptico refratário(EMER. Foram estudadas 50 crianças com EMER, internadas em UTI-pediátrica, composto pelos: Grupo Midazolam(A (n=24 prospectivo, e o Grupo Thiopental(B (n=26 histórico. Benzodiazepina e difenil-hidantoina e outros anticonvulsivantes foram previamente utilizadas nos dois grupos. Não havendo o controle das convulsões, no Grupo A os pacientes receberam uma dose de 200 mig/kg midazolam intravenoso em bolo, seguindo-se a infusão intravenosa contínua na razão de 0,25 a 15 mig/kg/min. No grupo B foi administrado thiopental, uma dose em bolo intravenosa de 1 mg/kg,, seguida de infusão intravenosa contínua na razão de 10-120 mig/kg/min. Em relação ao tempo de controle das crises e sua eficácia, não houve significância estatística para os dois grupos. No Grupo A houve significativamente menos complicações durante o tratamento: menos cianose (p=0,00006 e menos crianças necessitaram de ventilação assistida (p<0,00001. No Grupo A, 12,5% dos pacientes, na pós-terapia imediata, apresentaram alterações psíquicas, como agitação, confusão mental, alucinação visual.

  13. Malaria diagnosis and treatment under the strategy of the integrated management of childhood illness (IMCI): relevance of laboratory support from the rapid immunochromatographic tests of ICT Malaria P.f/P.v and OptiMal.

    Science.gov (United States)

    Tarimo, D S; Minjas, J N; Bygbjerg, I C

    2001-07-01

    The algorithm developed for the integrated management of childhood illness (IMCI) provides guidelines for the treatment of paediatric malaria. In areas where malaria is endemic, for example, the IMCI strategy may indicate that children who present with fever, a recent history of fever and/or pallor should receive antimalarial chemotherapy. In many holo-endemic areas, it is unclear whether laboratory tests to confirm that such signs are the result of malaria would be very relevant or useful. Children from a holo-endemic region of Tanzania were therefore checked for malarial parasites by microscopy and by using two rapid immunochromatographic tests (RIT) for the diagnosis of malaria (ICT Malaria P.f/P.v and OptiMal. At the time they were tested, each of these children had been targeted for antimalarial treatment (following the IMCI strategy) because of fever and/or pallor. Only 70% of the 395 children classified to receive antimalarial drugs by the IMCI algorithm had malarial parasitaemias (68.4% had Plasmodium falciparum trophozoites, 1.3% only P. falciparum gametocytes, 0.3% P. ovale and 0.3% P. malariae). As indicators of P. falciparum trophozoites in the peripheral blood, fever had a sensitivity of 93.0% and a specificity of 15.5% whereas pallor had a sensitivity of 72.2% and a specificity of 50.8%. The RIT both had very high corresponding sensitivities (of 100.0% for the ICT and 94.0% for OptiMal) but the specificity of the ICT (74.0%) was significantly lower than that for OptiMal (100.0%). Fever and pallor were significantly associated with the P. falciparum asexual parasitaemias that equalled or exceeded the threshold intensity (2000/microl) that has the optimum sensitivity and specificity for the definition of a malarial episode. Diagnostic likelihood ratios (DLR) showed that a positive result in the OptiMal test (DLR = infinity) was a better indication of malaria than a positive result in the ICT (DLR = 3.85). In fact, OptiMal had diagnostic reliability (0

  14. Mis17 is a regulatory module of the Mis6-Mal2-Sim4 centromere complex that is required for the recruitment of CenH3/CENP-A in fission yeast.

    Directory of Open Access Journals (Sweden)

    Yoshiharu Shiroiwa

    Full Text Available BACKGROUND: The centromere is the chromosome domain on which the mitotic kinetochore forms for proper segregation. Deposition of the centromeric histone H3 (CenH3, CENP-A is vital for the formation of centromere-specific chromatin. The Mis6-Mal2-Sim4 complex of the fission yeast S. pombe is required for the recruitment of CenH3 (Cnp1, but its function remains obscure. METHODOLOGY/PRINCIPAL FINDINGS: Mass spectrometry was performed on the proteins precipitated with Mis6- and Mis17-FLAG. The results together with the previously identified Sim4- and Mal2-TAP precipitated proteins indicated that the complex contains 12 subunits, Mis6, Sim4, Mal2, Mis15, Mis17, Cnl2, Fta1-4, Fta6-7, nine of which have human centromeric protein (CENP counterparts. Domain dissection indicated that the carboxy-half of Mis17 is functional, while its amino-half is regulatory. Overproduction of the amino-half caused strong negative dominance, which led to massive chromosome missegregation and hypersensitivity to the histone deacetylase inhibitor TSA. Mis17 was hyperphosphorylated and overproduction-induced negative dominance was abolished in six kinase-deletion mutants, ssp2 (AMPK, ppk9 (AMPK, ppk15 (Yak1, ppk30 (Ark1, wis4 (Ssk2, and lsk1 (P-TEFb. CONCLUSIONS: Mis17 may be a regulatory module of the Mis6 complex. Negative dominance of the Mis17 fragment is exerted while the complex and CenH3 remain at the centromere, a result that differs from the mislocalization seen in the mis17-362 mutant. The known functions of the kinases suggest an unexpected link between Mis17 and control of the cortex actin, nutrition, and signal/transcription. Possible interpretations are discussed.

  15. Luminescent phosphors, based on rare earth substituted oxyfluorides in the A(1){sub 3-x} A(2){sub x}MO{sub 4}F family with A(1)/A(2)=Sr, Ca, Ba and M=Al, Ga

    Energy Technology Data Exchange (ETDEWEB)

    Park, Sangmoon, E-mail: spark@silla.ac.k [Department of Engineering in Energy and Applied Chemistry, Silla University, Busan 617-736 (Korea, Republic of); Vogt, Thomas [NanoCenter and Department of Chemistry and Biochemistry, University of South Carolina, Columbia 29208, SC (United States)

    2009-09-15

    A new family of UV-activated phosphors made by substituting rare-earth activators such as trivalent Eu, Tb, Tm and Er into A(1){sub 3-x}A(2){sub x}MO{sub 4}F host lattices (A(1)/A(2)=Sr, Ca, Ba; M=Al, Ga) are introduced and their activation and emission spectra as well as their CIE values reported. The Tm-substituted system can be activated using light with a wavelength of 360 nm. Relative intensities of a family of Tb-substituted green phosphors activated at 254 nm and with emissions centered near 548 nm are discussed.

  16. Malária pulmonar: aspectos na tomografia computadorizada de alta resolução - relato de caso Pulmonary malaria: high-resolution computed tomography findings - a case report

    OpenAIRE

    Rosana Rodrigues; Edson Marchiori; Daniel Andrade Tinoco de Souza

    2004-01-01

    Neste trabalho é relatado o caso de paciente do sexo masculino, de 38 anos de idade, que desenvolveu quadro de malária com comprometimento pulmonar. A tomografia computadorizada de alta resolução evidenciou espessamento de septos interlobulares e de bainhas peribroncovasculares, com áreas esparsas de atenuação em vidro fosco e de consolidações, além de derrame pleural bilateral, aspectos compatíveis com edema pulmonar. O paciente recebeu tratamento específico, evoluindo bem e tendo alta 11 di...

  17. Intervención familiar para el manejo psicológico en pacientes oncológicos con mal pronóstico en el hospital de la misericordia

    OpenAIRE

    Martha Restrepo Forero; Ana Carolina Rodríguez Ibarra; Rubi Yasmín Ruiz Suárez

    2008-01-01

    Se diseñó un programa fundamentado en el modelo cognitivo conductual de Inoculación de Estrés e intervención en duelo anticipatorio basado en cuatro tareas. El programa fue aplicado a tres pacientes con mal pronóstico del Servicio de Oncohematología del Hospital de la Misericordia y a sus familias. Por medio de estudio de caso, se describieron factores de riesgo y de protección así como respuestas frente a dicha intervención. El análisis cualitativo de casos arrojó la descripción de respuesta...

  18. Mis17 Is a Regulatory Module of the Mis6-Mal2-Sim4 Centromere Complex That Is Required for the Recruitment of CenH3/CENP-A in Fission Yeast

    OpenAIRE

    Shiroiwa, Yoshiharu; Hayashi, Takeshi; Fujita, Yohta; Villar-Briones, Alejandro; Ikai, Nobuyasu; Takeda, Kojiro; Ebe, Masahiro; Yanagida, Mitsuhiro

    2011-01-01

    Background The centromere is the chromosome domain on which the mitotic kinetochore forms for proper segregation. Deposition of the centromeric histone H3 (CenH3, CENP-A) is vital for the formation of centromere-specific chromatin. The Mis6-Mal2-Sim4 complex of the fission yeast S. pombe is required for the recruitment of CenH3 (Cnp1), but its function remains obscure. Methodology/Principal Findings Mass spectrometry was performed on the proteins precipitated with Mis6- and Mis17-FLAG. The re...

  19. Propiedades interfaciales del surfactante pdms-peganhídrido maléico-ácido fumárico (pdms-peg-am-af) en solución acuosa

    OpenAIRE

    Johana Rodríguez; Edgardo Meza Fuentes; Maria Cecilia Azevedo Espiridiao

    2011-01-01

    En este estudio se determinaron las propiedadesinterfaciales en solución acuosadel surfactante del tipo PDMS-éster quecontiene polidimetilsiloxano (PDMS),polietilenglicol (PEG), anhídrido maléicoy ácido fumárico. Para el estudio delas propiedades interfaciales se emplearonlas técnicas tensiometría y espectroscopiaen la región del UV-Vis. En soluciónacuosa este surfactante mostró uncomportamiento complejo, que es dependientede la concentración. En este surfactantese observó un cambio brusco en...

  20. Design e concepção de vestuário funcional para bebés, com propriedades de repelência ao insecto da malária

    OpenAIRE

    Pinheiro, Cláudia Isabel de Sousa

    2011-01-01

    Doenças transmissíveis por insectos atingem milhões de pessoas em todo o mundo, causando milhares de mortes (WHO a, 2009). Actualmente, a malária é um dos principais problemas da humanidade, ocorrendo anualmente entre 300 a 500 milhões de infecções palúdicas severas, estimando-se cerca de 1 milhão de mortes, em que mais de 75% das vítimas são crianças africanas com idade inferior a 5 anos, infectadas pelo Plasmodium Falciparum (RBM, 2001-2010). Representa, ainda, risco elevado para viajantes ...

  1. Spoločenstvá suchozemských mäkkýšov severnej časti Devínskej Kobyly (Malé Karpaty)

    OpenAIRE

    Jozef Šteffek

    2005-01-01

    Present paper is focused on two topics. First topic is focused on evaluation of mollusc assemblages of northern part of the Devínska Kobyla hill (Malé Karpaty Mts.). The second topic was evaluation of all published data on molluscs of this area. The research was conducted during vegetation period of the year 1978. From 9 types of biotopes altogether 47 quantitative samples were sampled. The assemblages were evaluated on the base of constancy and dominance of the species. Altogether 7913 mollu...

  2. Mis17 Is a Regulatory Module of the Mis6-Mal2-Sim4 Centromere Complex That Is Required for the Recruitment of CenH3/CENP-A in Fission Yeast

    OpenAIRE

    Yoshiharu Shiroiwa; Takeshi Hayashi; Yohta Fujita; Alejandro Villar-Briones; Nobuyasu Ikai; Kojiro Takeda; Masahiro Ebe; Mitsuhiro Yanagida

    2011-01-01

    BACKGROUND: The centromere is the chromosome domain on which the mitotic kinetochore forms for proper segregation. Deposition of the centromeric histone H3 (CenH3, CENP-A) is vital for the formation of centromere-specific chromatin. The Mis6-Mal2-Sim4 complex of the fission yeast S. pombe is required for the recruitment of CenH3 (Cnp1), but its function remains obscure. METHODOLOGY/PRINCIPAL FINDINGS: Mass spectrometry was performed on the proteins precipitated with Mis6- and Mis17-FLAG. The ...

  3. Statistická transformace srážkových dat z regionálního klimatického modelu na specifické podmínky povodí Malše

    Czech Academy of Sciences Publication Activity Database

    Hnilica, Jan; Šípek, Václav

    Praha : Ústav pro hydrodynamiku AV ČR, v. v. i, 2011 - (Šír, M.; Tesař, M.), s. 137-142 ISBN 978-80-02-02290-9. [Hydrologie malého povodí 2011. Praha (CZ), 08.03.2011-10.03.2011] R&D Projects: GA AV ČR IAA300600901 Institutional research plan: CEZ:AV0Z20600510 Keywords : statistical downscaling * REMO model * gamma distribution Subject RIV: DA - Hydrology ; Limnology

  4. Faktoring – jedna z hlavních forem financování malých a středních podniků

    Directory of Open Access Journals (Sweden)

    Müllerová Libuše

    2009-12-01

    Full Text Available Faktoring představuje službu, kterou poskytují specializované faktoringové společnosti svým klientům v souvislosti s postoupením nebo se správou pohledávek. Ve své podstatě se jedná o určitý způsob úvěrování, využívaný zejména malými a středními podniky. V praxi existuje několik forem faktoringu v závislosti na tom, do jaké míry přechází na faktora vlastnictví pohledávek a rizika jejich nesplacení. Podle toho se pak faktoringové transakce promítají do účetnictví faktora i klienta. Vzhledem k tomu, že tato služba ani její formy není upravená žádným právním předpisem, postupují faktoringové společnosti často tak, že podmínky ve smlouvách – z důvodu daňových – často zakrývají svojí formou skutečný stav. Uvedený příspěvek základní formy faktoringu vymezuje, popisuje jejich správné účtování včetně daňových dopadů. Factoring is a service, which is offered by specialized factoring agencies to their clients in case of transfer (sale or governance of receivables. In fact, it represents a specific mode of crediting which is mostly preferred by small and medium enterprises. In practices of factoring several forms are differentiated depending on scale of property and risk transfer to the factor. According to these circumstances the factoring transactions are recognized by the factor and the client. The factoring services are not so far regulated by any legal provision. For this reason factoring agencies are proceeding in such a way, that contract conditions – because of tax considerations – hide by their form the substance. The paper describes the factoring forms and interprets their correct recognition on accounting, including tax consequences.

  5. Os Sistemas de Informação Geográfica e Detecção Remota na Determinação das Regiões de Risco por Malária na Guiné-Bissau

    OpenAIRE

    Nandaia, Morna

    2015-01-01

    A malária é uma doença infecciosa complexa, que resulta do “vírus” plasmodium, e manifesta-se sob cinco tipos distintos de espécies protozoários (plasmodium vivax, plasmodium ovale, plasmodium falciparum, plasmodium malariae e plasmodium Knowlesi), atacando sobretudo os glóbulos vermelhos. Considerada a quinta maior causa de morte por doenças infecciosas em todo o mundo após doenças respiratórias, VIH/SIDA, doenças diarreicas e tuberculose, no continente africano, a malária é considerada a...

  6. Associação de metemoglobinemia e deficiência de glicose-6-fosfato desidrogenase em pacientes com malária tratados com primaquina Association of methemoglobinemia and glucose-6-phosphate dehydrogenase deficiency in malaria patients treated with primaquine

    OpenAIRE

    Marli Stela Santana; Marcos Antonio Ferreira da Rocha; Ana Ruth Lima Arcanjo; José Felipe Jardim Sardinha; Wilson Duarte Alecrim; Maria das Graças Costa Alecrim

    2007-01-01

    Este estudo teve como objetivo verificar a ocorrência de metemoglobinemia em indivíduos deficientes da glicose-6-fosfato desidrogenase durante o tratamento da infecção malárica com primaquina. Foram selecionados pacientes com diagnóstico para malária por Plasmodium vivax ou mista V+F (Plasmodium vivax + Plasmodium falciparum), Grupo 1: com 74 indivíduos com diagnóstico clínico de metemoglobinemia e Grupo 2: 161 indivíduos sem diagnóstico clínico de metemoglobinemia. Quanto à deficiência da G6...

  7. Synthesis and characterization of aluminum and gallium complexes of heterocyclic thiosemicarbazones. crystal structures of Me2M[SC4H3CHNNC(S)SCH3] (M=Al, Ga)

    International Nuclear Information System (INIS)

    The synthesis and characterization of the monomeric group 13 heterocyclic thiosemicarbazone complexes Me2M[SC4H3CHNNC(S)SCH3] (M=Al (2), Ga (3)) are described. Compounds 2-3 were prepared using MMe3 (M=Al, Ga) in toluene with 2-thiophenecarboxaldehyde-S-methyldithiocarbazate under anaerobic conditions. These complexes have been characterized by 1H NMR, 13C NMR, elemental analyses, and single-crystal X-ray diffraction. 2 crystallizes in the monoclinic space group P21/c with unit cell parameters a=10.2930(5) A, b=18.564 (1) A, c=7.3812(6) A, V=1347.9(2) A3, Dcalc=1.342 gcm-3 for Z=4, 9281 reflections with Ibca with unit cell parameters a=13.340(3) A, b=19.9070(5) A, c=11.3690(2) A, V=2673.88(9) A3, Dcalc=1.511 gcm-3 for Z=8, 17004 reflections with I>3σ(I), R1=0.0480 and wR2=0.0524. Compound 3 is a monomeric gallium compound with a weak interaction between the pendant thiophene and the gallium center

  8. Electronic structure and magnetic properties of LiMn1.5M0.5O4 (M=Al, Mg, Ni, Fe) and LiMn2O4/TiO2 nanocrystalline electrode materials

    International Nuclear Information System (INIS)

    The process of sol–gel synthesis was applied to obtain LiMn1.5M0.5O4 (M=Al, Mg, Ni, Fe) and LiMn2O4/TiO2 nanopowders. The samples were characterized by following methods: X-ray diffraction (XRD), scanning electron microscopy (SEM/EDX), X-ray photoelectron spectroscopy (XPS) and SQUID magnetometry. XPS was used to examine the chemical composition and oxidation state of manganese, in particular the Mn3+/Mn4+ ratio from the deconvolution of the complex Mn3p lines. The size of the grains and crystallites were independently obtained from SEM images and XRD patterns, respectively. In all the cases a critical interplay of electronic (Mn3+/Mn4+ ratio), structural (unit cell volume) and magnetic properties was observed depending on the synthesis process. - Graphical abstract: SEM image of Li0.79Ni0.41Mn1.35O4.45 sample. Display Omitted - Highlights: • LiMn1.5M0.5O4 (M=Al, Mg, Ni, Fe) and LiMn2O4/TiO2 obtained by sol–gel method. • XRD method was used to determine the crystal structure. • SEM/EDX imaging have been done. • XPS electronic structure was examined and discussed. • Experimental effective magnetic moment and the calculated one were compared

  9. Prostorové rozhraní informačního systému malé obce řešené v Open Source Software

    Directory of Open Access Journals (Sweden)

    Karel Jedlička

    2006-12-01

    Full Text Available Příspěvek si klade za cíl představit možnosti open source software pro implementaci prostorového rozhraní informačního systému malé obce.Zabývá se návrhem projektu po jednotlivých částech: identifikace požadavků zastupitelského úřadu (uživatele systému, popis obecné architektury systému a volba vhodných (nekomerčních technologií pro jeho implementaci. Součástí projektu je i popis vyvinuté technologie pro import nejdůležitějších datových vrstev (informací o vlastnictví do systému.Článek je doplněn výčtem využitelných datových zdrojů pro informační systém malé obce v České republice.

  10. Development of a scar marker for Pierce's Disease strains of Xylella fastidiosa Desenvolvimento de um marcador scar para Xylella fastidiosa causadora do mal de Pierce

    Directory of Open Access Journals (Sweden)

    Regiane F. Travensolo

    2005-04-01

    Full Text Available The objective of this research was to develop a primer for a polymerase chain reaction specific for Xylella fastidiosa strains that cause Pierce's Disease (PD in grapes (Vitis vinifera. The DNA amplification of 23 different strains of X. fastidiosa, using a set of primers REP1-R (5'-IIIICGICGIATCCIGGC-3' and REP 2 (5'-ICGICTTATCIGGCCTAC-3' using the following program: 94 ºC/2 min; 35 X (94 ºC/1 min, 45 ºC/1 min and 72 ºC/1 min and 30 s 72 ºC/5 min, produced a fragment of 630 bp that differentiated the strains that cause disease in grapes from the other strains. However, REP banding patterns could not be considered reliable for detection because the REP1-R and REP 2 primers correspond to repetitive sequences, which are found throughout the bacterial genome. The amplified product of 630 bp was eluted from the agarose gel, purified and sequenced. The nucleotide sequence information was used to identify and synthesize an specific oligonucleotide for X. fastidiosa strains that cause Pierce's Disease denominated Xf-1 (5'-CGGGGGTGTAGGAGGGGTTGT-3' which was used jointly with the REP-2 primer at the following conditions: 94 ºC/2 min; 35 X (94 ºC/1 min, 62 ºC/1 min; 72 ºC/1 min and 30 s 72 ºC/10 min. The DNAs isolated from strains of X. fastidiosa from other hosts [almond (Prumus amygdalus, citrus (Citrus spp., coffee (Coffea arabica, elm (Ulmus americana, mulberry (Morus rubra, oak (Quercus rubra, periwinkle wilt (Catharantus roseus, plums (Prunus salicina and ragweed (Ambrosia artemisiifolia] and also from other Gram negative and positive bacteria were submitted to amplification with a pair of primers Xf-1/REP 2 to verify its specificity. A fragment, about 350 bp, was amplified only when the DNA from strains of X. fastidiosa isolated from grapes was employed.O objetivo deste trabalho foi desenvolver um oligonucleotídeo iniciador para reação em cadeia da polimerase (PCR específico para as estirpes de Xylella fastidiosa que causam o mal de

  11. Factores asociados a mal estado de salud percibido o a mala calidad de vida en personas mayores de 65 años

    Directory of Open Access Journals (Sweden)

    Azpiazu Garrido Mercedes

    2002-01-01

    Full Text Available Fundamento: Hoy en día, en los países desarrollados, llegar a una edad avanzada ha dejado de ser algo excepcional, sin embargo muchas personas no logran envejecer con una buena calidad de vida. El presente trabajo tiene como objetivos, contribuir a un mejor conocimiento de los principales factores que influyen en la calidad de vida y la percepción de la salud de los mayores de 65 años, así como determinar qué ventajas y desventajas presenta cada uno de los tres instrumentos de medida de la salud y la calidad de vida frente a los otros dos instrumentos utilizados. Métodos: A partir de 911 encuestas a personas mayores de 65 años no institucionalizadas, realizadas a domicilio, se hizo un análisis multivariante mediante regresión logística, poniendo en relación los resultados obtenidos en el Perfil de Salud de Nottingham (PSN, el Euroqol y el EAS con las caracterísiticas sociodemográficas, el nivel de recursos económicos, el grado de apoyo sociofamiliar, el estado de salud física y mental y la capacidad funcional. Resultados: Los principales factores que se asocian con la percepción de un mal estado de salud y mala calidad de vida en el Euroqol y el PSN son los trastornos de ansiedad (Odd Ratios entre 1,8(IC:1,2-2,8 para movilidad y 7,9(IC:4,5-13,9 para Perfil ≠11111, trastornos depresivos (OR:1,8(IC:1,3-2,6 para dolor/malestar- 3,3(IC:2,1-5,1 para aislamiento social, falta de ejercicio (OR:1,4 (IC:1-2,1 para ansiedad/depresión -3,9(IC:2,5-6,2 para actividades cotidianas, dependencia para las actividades básicas de la vida diaria (OR:0,5(IC:0,3-0,9 para reacción emocional - 4,8(IC:3-7,6 para actividades cotidianas y dependencia para las actividades instrumentales de la vida diaria (OR:1,5(IC:1,1-2,1 para Escala Visual Analógicac<70 - 7,1(IC:2,9-17,2 para cuidado personal. Conclusiones: La salud mental y la capacidad funcional son los factores que más influyen en la percepción del estado de salud y la calidad de vida de las

  12. Forage Legume Species for Cutting on Heavy Clay Soils with Bad Drainage Especies Leguminosas Forrajeras para Cortes en Suelos Arcillosos de Mal Drenaje

    Directory of Open Access Journals (Sweden)

    Patricio Soto O.

    2005-06-01

    Full Text Available Forage yield of three species of leguminous forrages: alfalfa, Medicago sativa L.; red clover, Trifolium pratense L.; and birdsfoot trefoil Lotus corniculatus L. was evaluated in waterlogged soils in the VIIth Region, Chile, during four seasons with three fertilization rates: 2 t lime ha-1 + 150 kg P2O5 ha-1; no lime application + 150 kg P2O5 ha-1; and no lime + 70 kg of P2O5 ha-1, applying half of the fertilizer dose during the seasons following establishment. The experimental design was randomized complete blocks with four repetitions. An analysis of variance was carried out and means were compared using the Duncan test (P ≤ 0.05. Alfalfa needed high fertilization to achieve production comparable to birdsfoot trefoil and red clover, reaching its best production with complete fertilization in the first season (4.6 t DM ha-1. The red clover maintained high production until the second season independent of the fertilizer dose (11.8 t DM ha-1, but began to decline in the third season. The birdsfoot trefoil was the species best adapted to these soil conditions, DM yield was not affected by the dose of phosphorus in the four years, reaching production levels of 7.1 t DM ha-1 during the fourth season.Se evaluó el rendimiento de forraje en tres especies de leguminosas forrajeras: alfalfa, Medicago sativa L.; trébol rosado, Trifolium pratense L.; y lotera, Lotus corniculatus L. en suelos arcillosos de mal drenaje de la VII Región, Chile, durante cuatro temporadas, con tres niveles de fertlización: 2 t de cal ha-1 + 150 kg de P2O5 ha-1; sin aplicación de cal + 150 kg de P2O5 ha-1; y sin cal + 70 kg de P2O5 ha-1, aplicando durante las siguientes temporadas la mitad de la dosis de fertilizante aplicado al establecimiento. El diseño experimental utilizado fue de bloques completos al azar con cuatro repeticiones. Se realizó análisis de varianza y en la comparación de medias se usó la prueba de Duncan (P ≤ 0,05. La alfalfa necesitó una alta

  13. Ejercicio y la detección del mal agudo de montaña grave Exercise and the detection of severe acute mountain sickness

    Directory of Open Access Journals (Sweden)

    Adrián Garófoli

    2010-02-01

    Full Text Available El mal agudo de montaña (MAM es un conjunto de síntomas inespecíficos padecidos por sujetos que ascienden rápidamente desde baja a alta altura sin adecuada aclimatación. Usualmente es autolimitado, pero las formas graves (edema pulmonar y cerebral pueden causar la muerte. La hipoxemia exagerada en reposo está relacionada con el desarrollo de MAM pero su valor predictivo es limitado. Dado que el ejercicio en altura se acompaña de mayor hipoxemia y síntomas, postulamos el valor predictivo de un simple test de ejercicio para pronosticar MAM grave. Se estudió el valor predictivo de la saturación de oxígeno en reposo y ejercicio submáximo a 2.700 m y 4 300 m en 63 sujetos que ascendían al cerro Aconcagua (6 962 m. Se consideró desaturación de oxígeno con ejercicio a una disminución = 5% respecto al reposo. Se utilizó la escala de Lake-Louise para establecer la presencia de MAM grave. Seis sujetos presentaron MAM grave (9.5% y requirieron evacuación. La saturación de oxígeno en reposo a 2.700 m no fue significativa para clasificar sujetos que luego desarrollaron MAM grave. Por el contrario, la asociación de desaturación durante el ejercicio a 2.700 m más la saturación inapropiada en reposo a 4.300 m fue significativa para clasificar a los sujetos que desarrollaron MAM grave con un valor predictivo positivo de 80% y un valor predictivo negativo del 97%. Nuestros resultados son relevantes para el montañismo y sugieren la adición de un simple test de ejercicio en la predicción del MAM grave.Acute mountain sickness (AMS is a group of non-specific symptoms, seen in subjects that ascend from low to high altitude too quickly, without allowing sufficient time to acclimatize. Usually it is self-limiting, but the severe forms (pulmonary and cerebral edema can be fatal. Exaggerated hypoxemia at rest is related to later development of AMS but its predictive value is limited. Since exercise at altitude induces greater hypoxemia and

  14. Fertilizantes e espaçamento entre plantas na produtividade da couve-da-Malásia Fertilizers and spacing between plants in the yield of Malaysian cabbage

    Directory of Open Access Journals (Sweden)

    Wanessa Resende Ferreira

    2002-12-01

    Full Text Available As brássicas têm sido objeto constante de pesquisa devido à sua importância na alimentação humana, seja pela quantidade consumida, pelo alto valor nutricional ou por sua elevada produtividade. Brassica chinensis var. parachinensis foi introduzida no Brasil, Uberlândia, em 1992, destacando-se em relação a outras brássicas por seu alto teor de vitaminas A e C, cálcio e ferro, estando pronta para consumo em aproximadamente 30 dias. A produtividade biológica e agronômica dessa variedade foi analisada utilizando-se três tipos de fertilizantes e três espaçamentos entre plantas, visando subsidiar sua produção em escala comercial. A área foliar, massa da matéria seca e taxa de crescimento absoluto foram significativamente maiores com adubação mineral em relação à adubação orgânica. Os maiores valores referentes à taxa de crescimento relativo e taxa assimilatória líquida foram registrados em plantas mantidas nos maiores espaçamentos (30x20 e 30x30 cm. A maior produtividade agronômica foi alcançada no menor espaçamento (30x10 cm, com adubação mineral, sendo registrados 21,5 t ha-1, valor muito próximo ao registrado na Malásia e China onde essa hortaliça é cultivada em larga escala.Brassica crops have been widely studied due to their importance as food for human consumption, especially in relation to their nutritional value. Both yield and consumption are high. Brassica chinensis var. parachinensis was introduced in Brazil, in Uberlândia, in 1992, surpassing other Brassica due to its high content of vitamins A and C, calcium and iron, and being ready for consumption in about 30 days. The biological and agronomic yield of this variety was analyzed under three kinds of fertilizers and three spacings between plants with a view to its production on a commercial scale. The leaf area, dry matter mass, and absolute growth rate were higher with mineral than organic fertilizer. High values for relative growth rate and net

  15. Genesis of the Assif El Mal Zn-Pb (Cu, Ag) vein deposit. An extension-related Mesozoic vein system in the High Atlas of Morocco. Structural, mineralogical, and geochemical evidence

    Science.gov (United States)

    Bouabdellah, M.; Beaudoin, G.; Leach, D.L.; Grandia, F.; Cardellach, E.

    2009-01-01

    The Assif El Mal Zn-Pb (Cu-Ag) vein system, located in the northern flank of the High Atlas of Marrakech (Morocco), is hosted in a Cambro-Ordovician volcaniclastic and metasedimentary sequence composed of graywacke, siltstone, pelite, and shale interlayered with minor tuff and mudstone. Intrusion of synorogenic to postorogenic Late Hercynian peraluminous granitoids has contact metamorphosed the host rocks giving rise to a metamorphic assemblage of quartz, plagioclase, biotite, muscovite, chlorite, amphibole, chloritoid, and garnet. The Assif El Mal Zn-Pb (Cu-Ag) mineralization forms subvertical veins with ribbon, fault breccia, cockade, comb, and crack and seal textures. Two-phase liquid-vapor fluid inclusions that were trapped during several stages occur in quartz and sphalerite. Primary inclusion fluids exhibit Th mean values ranging from 104??C to 198??C. Final ice-melting temperatures range from -8.1??C to -12.8??C, corresponding to salinities of ???15 wt.% NaCl equiv. Halogen data suggest that the salinity of the ore fluids was largely due to evaporation of seawater. Late secondary fluid inclusions have either Ca-rich, saline (26 wt.% NaCl equiv.), or very dilute (3.5 wt.% NaCl equiv.) compositions and homogenization temperatures ranging from 75??C to 150??C. The ??18O and ??D fluid values suggest an isotopically heterogeneous fluid source involving mixing between connate seawater and black-shale-derived organic waters. Low ??13CVPDB values ranging from -7.5??? to -7.7??? indicate a homogeneous carbon source, possibly organic matter disseminated in black shale hosting the Zn-Pb (Cu-Ag) veins. The calculated ??34SH2S values for reduced sulfur (22.5??? to 24.3???) are most likely from reduction of SO42- in trapped seawater sulfate or evaporite in the host rocks. Reduction of sulfate probably occurred through thermochemical sulfate reduction in which organic matter was oxidized to produce CO2 which ultimately led to precipitation of saddle dolomite with

  16. Entre recueil et intertextes : le poème.Autour de l’insertion de « Sonnet d’automne »dans Les Fleurs du Mal de 1861

    OpenAIRE

    Adam, Jean-Michel; Heidmann, Ute

    2008-01-01

    Cet article aborde un point négligé par la théorie du texte : la relation entre poème et recueil. À ces relations entre textes proches, nous ajoutons l'examen d'une intertextualité déclenchée par l'arrivée, en 1861, de « Sonnet d'automne » dans le recueil des Fleurs du Mal. La découverte d'une intertextualité avec le Faust de Goethe, médiatisée par la traduction de Nerval, a été rendue possible par la collaboration d'une comparatiste et d'un linguiste. L'extension du champ de l'analyse de dis...

  17. Vacinas em desenvolvimento: estreptococo do grupo B, herpes-zóster, HIV, malária e dengue Vaccines under development: group B streptococcus, herpes-zoster, HIV, malaria and dengue

    OpenAIRE

    Luiz Jacintho da Silva; Rosana Richtmann

    2006-01-01

    OBJETIVOS: As vacinas contra o estreptococo B, o herpes-zóster, o HIV, a malária e a dengue, selecionadas por critérios de comercialização iminente ou devido a problemas específicos para sua obtenção, foram objeto de uma revisão sobre o estado atual do seu desenvolvimento. FONTE DOS DADOS:Foi realizada revisão da literatura através da MEDLINE no período de 1996 a 2006, sobre a epidemiologia e imunologia das doenças, analisando tanto os maiores problemas para a obtenção de uma vacina como o es...

  18. La quête de la « Terre sans mal » chez les peuples traditionnels : l’exemple des Tupi-Guarani (Amérique du Sud)

    OpenAIRE

    Navet, Eric

    2005-01-01

    Le chaman incarne au mieux les valeurs, exprimées dans le mythe, d’un mode d’être, de penser et d’agir qui vise à préserver un monde fait d’« ordre, d’harmonie, et de beauté » – selon les Indiens Ojibwé des Grands Lacs – qui nous rapproche du premier état de la Création que les Tupi-Guarani appellent la « Terre sans mal ». Comme le rêve, l’usage de psychotropes parfois réservés aux seuls chamans (champignons hallucinogènes, takweni...), ou d’un usage collectif (bière de manioc, ayahuasca, pey...

  19. Estudi de les diferències psicopatològiques en pacients amb mal de cap crònic, episòdic i control. Relació amb la resposta al tractament

    OpenAIRE

    Sala Matavera, Isabel

    2010-01-01

    La cefalea o mal de cap és un dels motius de consulta més freqüents als serveis de neurologia i molt prevalent a la població general. Sovint, el maneig és difícil perquè a vegades poden coexistir més d’un tipus de cefalea, no es posa suficient atenció a la comorbilitat (psicopatologia) o a altres factors que poden empitjorar la progressió de la cefalea com per exemple l’abús farmacològic. Aquest treball té per objectius (1) comparar els perfils psicopatològics de pacients amb cefalea cr...

  20. Synthesis and characterization of aluminum and gallium complexes of heterocyclic thiosemicarbazones. crystal structures of Me{sub 2}M[SC{sub 4}H{sub 3}CHNNC(S)SCH{sub 3}] (M=Al, Ga)

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Young Jin; Yoo, Byung Woo; Kang, Sang Ook; Ko, Jae Jung [Korea Univ., Chochiwon (Korea, Republic of); Kang, Seung Joo [Korea National University of Education, Chongwon (Korea, Republic of)

    1998-01-01

    The synthesis and characterization of the monomeric group 13 heterocyclic thiosemicarbazone complexes Me{sub 2}M[SC{sub 4}H{sub 3}CHNNC(S)SCH{sub 3}] (M=Al (2), Ga (3)) are described. Compounds 2-3 were prepared using MMe{sub 3} (M=Al, Ga) in toluene with 2-thiophenecarboxaldehyde-S-methyldithiocarbazate under anaerobic conditions. These complexes have been characterized by {sup 1}H NMR, {sup 13}C NMR, elemental analyses, and single-crystal X-ray diffraction. 2 crystallizes in the monoclinic space group P2{sub 1}/c with unit cell parameters a=10.2930(5) A, b=18.564 (1) A, c=7.3812(6) A, V=1347.9(2) A{sup 3}, D{sub calc}=1.342 gcm{sup -3} for Z=4, 9281 reflections with I<3{sigma} (I), R1=0.0500 and wR2=0.0526. 3 crystallizes in the orthorhombic space group P{sub bca} with unit cell parameters a=13.340(3) A, b=19.9070(5) A, c=11.3690(2) A, V=2673.88(9) A{sup 3}, D{sub calc}=1.511 gcm{sup -3} for Z=8, 17004 reflections with I>3{sigma}(I), R1=0.0480 and wR2=0.0524. Compound 3 is a monomeric gallium compound with a weak interaction between the pendant thiophene and the gallium center.

  1. Performance of an immunochromatography test for vivax malaria in the Amazon region, Brazil Desempenho de um teste de imunocromatografia para malária por P. vivax na Amazônia

    Directory of Open Access Journals (Sweden)

    Alberto Ferreira Figueiredo Filho

    2003-06-01

    Full Text Available The study was carried out to evaluate the diagnostic performance of the ICT malaria Pf/PvTM test for vivax malaria diagnosis in Belém, Amazon region, Brazil. The results of blood malaria parasites examination using an immunochromatography test were compared with thick blood film (TBF examination. It was also evaluated the performance of this test storaged at three different temperatures (25°C, 30°C, and 37°C for 24 hours before use. Overall sensitivity of ICT Pf/PvTM was 61.8% with a specificity of 100%, positive and negative predictive value of 100% and 71.8%, respectively and accuracy of 80.6%. The test sensitivity was independent of the parasite density. This test needs to be further reviewed in order to have better performance for P. vivax malaria diagnosis.Avaliação do teste ICT malaria Pf/PvTM para o diagnóstico da malária por P. vivax em Belém, Estado do Pará. Foram comparados os resultados do teste imunocromatográfico com a gota espessa (GE e avaliados o comportamento desse teste, estocado a três temperaturas distintas (25(0C/ 30(0C/ 37(0C, 24 horas antes de seu uso. A sensibilidade do ICT malaria Pf/PvTM foi de 61,8% com especificidade de 100%, valores preditivo positivo e negativo de 100% e 71,8%, respectivamente, e acurácia de 80,67%. A sensibilidade desse teste foi independente da densidade parasitária. Este teste necessita de reavaliação para melhorar o seu comportamento no diagnóstico da malária por P. vivax.

  2. EFFECT OF SOME SYSTEMIC DRUGS IN THE PREVENTIVE CONTROL OF THE MAL-DO-PANAMÁ (Fusarium oxysporum f.sp. cubense (EF. SN. & H. OF THE BANANA TREE (Musa sapientum L. EFEITOS DE ALGUMAS DROGAS SISTÊMICAS NO CONTROLE PREVENTIVO DO MAL DO PANAMÁ (Fusarim oxysporum f. sp. Cubense (Ef. Sn. & H. DA BANANEIRA (Musa sapientum L.

    Directory of Open Access Journals (Sweden)

    Yvo de Carvalho

    2007-09-01

    Full Text Available

    With the objective of studying the effect of some systemic drugs on the fungus, Fusarium oxysporim f. sp. cubense (Ef. Sn. & H. , which attacks the rootstalk tissue of the cultivated ‘Maçã’ banana (Musa sapientum L. an experiment was set up in virgin “cerrado” soil , which had been previously covered with natural vegetation. The effects of Benlate (benomyl and Plantvax (oxamyl, both in doses of 0.1, 0.2, and 0.5%, as well as Mycostatin (nistatina in doses of 0.02, 0.05, and 0.1%, and combination of Mycostatin plus soluble Neantina (chloride of metoxi-etil mercurio at 3.7% in doses of 0.02 + 0.15%, 0.05 + 0.3%, and 0.1 + 0.5%, were tested by immersing the infected roostalks in the solutions for a ten-minute period. The rootstalks used had been naturally infected by the fungus. The experiment design used was randomized blocks with four (4 repetitions of twenty-six (26 treatments. Each parcel was composed of four (4 plants. The results observed in February of 1974 revealed an indiscriminate incidence of the ";Mal do Panamá” on the plants of all treatments, demonstrating that none of them was sufficiently effective in erradicating the pathogen established in the rootstalk tissues. It is suggested, because of root damage and the subsequent inadequate penetration by the fungicides, that this lack of absorption was responsible for the unsuccessful attempts at controlling the disease. It was concluded that the control of this disease is neither possible nor viable under the conditions in which the experiment was executed, using the above-mentioned method of fungicide application and preparation of the rootstalk. Changes in procedure are recommended for future experiments.

    Com o objetivo de estudar o efeito de algumas drogas sistêmicas sobre o fungo Fusarium oxysporim f. sp. cubense (Ef. Sn. & H

  3. O Enigma do Mal: uma leitura do 'De casu diaboli'de Santo Anselmo (The enigma of evil: a reading of St. Anselm’s De casu diaboli - DOI: 10.5752/P.2175-5841.2013v11n32p1551

    Directory of Open Access Journals (Sweden)

    Manoel Luís Cardoso Vasconcellos

    2013-12-01

    Full Text Available O presente artigo quer investigar o problema do mal na perspectiva de Santo Anselmo, tomando como ponto de partida sua obra De casu diaboli, onde o tema é abordado, a partir da íntima ligação entre mal e pecado. Ao enfocar o mal na perspectiva da queda diabólica, o Doutor Magnífico intenta mostrar a conexão entre vontade, liberdade e justiça. Sua preocupação é investigar o significado moral da má escolha, realizada por uma criatura racional e puramente espiritual, feita boa e para ser boa. O pecado, consoante o autor, não está em almejar a felicidade, pois tal desejo é dádiva divina; o mal praticado pelo anjo está, precisamente, em querer a felicidade fora da justiça, isto é, ao querer ser feliz, ele foi de encontro ao que ele deveria ser: quis ser semelhante a Deus, extrapolando a sua própria natureza, pois ele desejou algo que, enquanto criatura, não caberia a ele almejar. Este é o ponto de partida para analisar o mal e sua mais dramática consequência, o sofrimento. Palavras-chave: Mal. Vontade. Justiça. Anselmo.   Abstract This article aims to investigate the problem of evil in Saint Anselm, especially in his treatise De casu diaboli. He approaches this issue from the close connection between evil and sin. Upon analyzing evil from the diabolic fall perspective, Dr. Magnificent tries to establish a connection between will, freedom and justice. This text investigates the moral meaning of misconduct, carried out by a rational and purely spiritual creature that was created good and meant to be good. Seeking for happiness is not itself a sin, according to the author, for such a wish is a gift from God. The evil done by the angel lies in the act of wanting happiness without justice, that is, on wanting to be happy, the angel contradicted what he was supposed to be: he wanted to be like God, transcending his own nature, as he wished for something that, as a creature, he was not fit to wish for. This is the starting point to

  4. Associação de eventos de vida produtores de estresse e mal-estar psicológico: um estudo de base populacional Association of stressful life events and psychological distress: a community-based study

    Directory of Open Access Journals (Sweden)

    Felipe Sparrenberger

    2004-02-01

    Full Text Available Foi realizado, em 1999, estudo transversal para investigar a associação entre determinados eventos produtores de estresse e a sensação de mal-estar psicológico. A Escala de Faces foi usada para medir o desfecho. A ocorrência de morte e doença em familiar, separação conjugal, roubo, acidente, migração e perda do emprego no ano anterior à entrevista, foi investigada entre 3.942 pessoas maiores de vinte anos de idade. A análise por regressão logística seguiu modelo hierárquico incluindo, no primeiro nível, características sócio-demográficas individuais; no segundo, eventos estressantes e, no terceiro, o mal-estar psicológico. Acidente e migração não se associaram ao desfecho. O maior efeito foi para separação conjugal (OR ajustada de 2,34. Os mais altos riscos atribuíveis na população foram os das variáveis sócio-econômicas (escolaridade 38,2% e renda 32,3% e o da ocorrência de pelo menos um dos eventos (36,4%. Atuação no plano das políticas públicas, visando a reduzir a ocorrência de eventos sociais negativos e, no plano individual, auxiliando as pessoas a lidar melhor com estes fatos da vida, poderiam contribuir para reduzir substancialmente a sensação de mal-estar psicológico.A cross-sectional study was conducted in 1999 to investigate the association between stressful psychosocial events and psychological distress. A Faces Scale was used to measure the outcome. Death and illness in the family, divorce, robbery, injury, migration, and loss of employment in the previous year were investigated through interviews with 3,942 individuals over 20 years. Logistic regression followed a hierarchical model using socio-demographic characteristics at the first level; psychosocial events at the second; and psychological distress at the third. Injury and migration were not associated with the outcome. The strongest effect was associated with divorce (adjusted OR = 2.34. The highest population-attributable risks were

  5. Sağmal İneklerin Meme Başı Derileri ve Çiğ Sütlerinden İzole Edilen Staphylococcus aureus’ların Patojenite Özellikleri ile Bazı Antibiyotiklere Duyarlılıkları / The Pathogenic Properties and the Varied Antibiotic Sensitivities of S. aureus Isolated from T

    OpenAIRE

    Alişarlı, Mustafa; SOLMAZ, Hasan

    2011-01-01

    ÖZET: Bu çalışmada, sağmal ineklerin meme başı derileri ve çiğ süt örneklerinde Staphylococcus aureus’un yaygınlığı ve izole edilen S. aureus’ların termonükleaz ve enterotoksijenik özellikleri ile bunların bazı antibiyotiklere duyarlılıkları araştırılmıştır. Bu amaçla, Van ili çevresindeki 5 farklı çiftlikten 100 sağmal süt ineğine ait 100 adet çiğ süt (80 adet süt örneği California Mastitis Tes...

  6. A ocorrência de malária em quatro municípios do estado do Pará, de 1988 a 2005, e sua relação com o desmatamento Occurrence of malaria in four cities in the state of Pará during 1988 to 2005 and its relationships with deforestation

    OpenAIRE

    Andressa Tavares Parente; Everaldo Barreiros de Souza; João Batista Miranda Ribeiro

    2012-01-01

    O objetivo deste trabalho foi estudar a ocorrência de malária em quatro diferentes regiões representativas do estado do Pará, buscando suas possíveis relações com as taxas de desmatamento. Foi realizado um estudo retrospectivo, com dados secundários, no período de 1988 a 2005, através de casos de malária registrados em quatro municípios do Estado (Anajás, Itaituba, Santana do Araguaia e Viseu), como também das taxas de desmatamento fornecidas pelo PRODES-INPE. Aplicou-se a técnica dos Quantis...

  7. Réaction du polyisobutène chloré sur l'anhydride maléique : mécanisme. Catalyse par l'anhydride dichloromaléique Reaction of Chlorinated Polyisobutene on Maleic Anhydride. Mechanism. Catalysis by Dichloromaleic Anhydride

    OpenAIRE

    Sillion B.; Weill J.

    2006-01-01

    Dans cet article le mécanisme de la réaction de condensation du polyisobutène chloré sur l'anhydride maléique, qui sert dans la synthèse d'additif pour lubrifiant, est étudié par une cinétique globale et par un travail sur composés modèles. Il est montré que, dans cette réaction, l'anhydride maléique joue un double rôle : de catalyseur de déshydrochloration par une réactivité de type acide de Lewis organique, de réactif comme diénophile. Grâce à ces résultats, il est proposé une catalyse par ...

  8. Malária no município de Humaitá, estado do Amazonas: XXI. Prevalência da deficiência de glicose-6-fosfato desidrogenase (G6PD) Em amostra da população e em doentes com malaria causada pelo Plasmodium falciparum

    OpenAIRE

    Benedito Barraviera; Domingos Alves Meira; Paulo Eduardo de Abreu Machado; Paulo Roberto Curi

    1987-01-01

    Os autores estudaram a prevalência da deficiência de glicose-6-fosfato desidrogenase (G6PD), pelo método de BREWER et alii, em 141 indivíduos da população do município de Humaitá, Estado do Amazonas. Destes, 128 eram amazônides, 67 dos quais nunca tiveram malária, enquanto que 61 tinham tido ou estavam tendo a doença; os 13 restantes que estavam com malária não eram arnazônides. Os resultados revelaram que 7 arnazônides (4,96%), eram deficientes. Destes, 5 eram do sexo feminino e 2 do masculi...

  9. Alterações clínicolaboratoriais em pacientes com malária por Plasmodium vivax e deficiência de glicose-6-fosfato desidrogenase tratados com 0,50mg/kg/dia de primaquina Clinical and laboratorial alterations in Plasmodium vivax malaria patients and glucose-6-phosphate dehydrogenase deficiency treated with primaquine at 0.50mg/kg/day

    OpenAIRE

    Mônica C.M. Silva; Eliane B. Santos; Elenild G. Costa; Manoel G. S. Filho; Guerreiro, João F.; Póvoa, Marinete M.

    2004-01-01

    O efeito adverso da primaquina na dose de 0,50mg/kg/dia foi investigado em onze pacientes com malária vivax (três com deficiência de glicose-6-fosfato desidrogenase). Alterações clínicas e laboratoriais indicaram hemólise aguda apenas nos enzimopênicos, o que fez com que o tratamento fosse interrompido. Nossos resultados sugerem a necessidade do emprego de um teste de triagem para a deficiência de G6PD em áreas endêmicas de malária vivax a fim de se evitar complicações causadas pelo uso da pr...

  10. Conhecimentos, práticas e percepções de profissionais de saúde sobre o tratamento de malária não complicada em municípios de alto risco da Amazônia Legal Uncomplicated malaria treatment in the Brazilian Amazon: knowledge, practices and perceptions of health workers in high-incidence municipalities

    OpenAIRE

    Claudia Garcia Serpa Osorio-de-Castro; Elaine Silva Miranda; Ângela Esher; Mônica Rodrigues Campos; Juliana de Castro Brasil; Ana Cristina Soares Ferreira; Isabel Cristina Martins Emmerick

    2011-01-01

    O controle da malária no Brasil conta com diagnóstico precoce e tratamento adequado e oportuno como estratégia para cura rápida e duradoura. Consequências clínicas e resistência aos antimaláricos podem resultar de falhas na prescrição, dispensação e aceitação dos profissionais aos esquemas terapêuticos propostos. Objetivou-se avaliar conhecimentos, práticas, percepções e atitudes de profissionais envolvidos na assistência farmacêutica à malária, frente ao protocolo oficial e a possíveis falha...

  11. Preliminary data from {gamma}-cardiography during the abatement of an asthmatic attack (1961); Premieres donnees de la {gamma}-cardiographie au decours de l'etat de mal asthmatique (1961)

    Energy Technology Data Exchange (ETDEWEB)

    Georges, R.; Vernejoul, P. de; Raynaud, C.; Blanchon, P.; Kellershohn, C.; Turiaf, J. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1961-07-01

    The authors used gamma cardiology during the abatement of 16 cases of asthma with a view to detecting heart attacks not otherwise visible with routine methods of examination: clinical, radiological and electro-cardio-graphical. In gamma cardiology, a radioactive indicator is used and its path followed in the cavities of the heart. The method makes it possible to study the circulation in the right heart, the pulmonary crossing, and the left heart, as well as evaluation of the heart-flow. As a result of their investigations the authors, after having discussed the significance of the data obtained with the method, suggest that it is possible by the use of gamma cardiography during the abatement of an asthma attack: 1- To confirm attacks of the right heart which have already been detected by ordinary methods. 2- To confirm the presence of modifications in the recorded curves which suggest, in the case of the left heart, possible attack; such on attack is also indicated, in a small number of cases, by electrocardiography curves. Some considerations are put forward by the authors concerning the physiopathology of attacks on the left heart. (authors) [French] Les auteurs ont fait appel a la gammacardiographie au decours de 16 cas d'etat de mal asthmatique, dans le but d'objectiver des atteintes cardiaques incapables d'etre revelees par les moyens d'exploration de routine: cliniques, radiologiques et electrocardiographiques. La gammacardiographie est un procede qui enregistre a l'aide d'un indicateur radioactif, le trajet de celui-ci dans les cavites cardiaques. Elle permet l'etude de la circulation dans le coeur droit, de la traversee pulmonaire, et le coeur gauche, de meme que le calcul du debit cardiaque. Au terme de leurs investigations, les auteurs apres avoir discute la signification des donnees fournies par la methode admettent que la gammacardiographie objective au secours de l'etat de mal asthmatique: 1- La confirmation de l

  12. ENFERMIDADES DIAGNOSTICADAS NA GENITÁLIA EXTERNA DE TOUROS: ESTUDO RETROSPECTIVO (2007 – 2013)

    OpenAIRE

    Luiz Antônio Franco da Silva; Valcinir Aloísio Scalla Vulcani; Fabiano José Ferreira de Sant'Ana; Bruno Moraes Assis; Andressa Sabine Rabbers

    2015-01-01

    Despite the importance of knowing epidemiological data on diseases that affect the external genitalia of bulls, few investigations have been conducted on the topic. This work aimed to conduct an epidemiological study of diseases diagnosed in the external genitalia of bulls in 215 farms distributed in the five mesoregions of the state of Goiás, Brazil, between 2007 and 2013. We verified that the largest number of cases were observed at southwestern region (64 %), followed by the northwes...

  13. ENFERMIDADES DIAGNOSTICADAS NA GENITÁLIA EXTERNA DE TOUROS: ESTUDO RETROSPECTIVO (2007 – 2013

    Directory of Open Access Journals (Sweden)

    Luiz Antônio Franco da Silva

    2015-01-01

    Full Text Available Despite the importance of knowing epidemiological data on diseases that affect the external genitalia of bulls, few investigations have been conducted on the topic. This work aimed to conduct an epidemiological study of diseases diagnosed in the external genitalia of bulls in 215 farms distributed in the five mesoregions of the state of Goiás, Brazil, between 2007 and 2013. We verified that the largest number of cases were observed at southwestern region (64 %, followed by the northwestern region (18.5 %. We found that of the affected bulls, 156 (71.89 % were Zebu, 47 (21.66% taurine and 14 (6.45 % were mixed breeds. Among the diseases, acropostite-phimosis was the more frequent, followed by fibropapiloma of the glans, prepuce abscess and penile fracture. The main risk factors were multifactorial aspects, including the morphological condition of the animals, environment, management and traumas. In many cases, the absence or insufficient number of trained veterinarians who work on the field was mentioned as one of the major bottlenecks for the realization of the diagnosis, treatment and prevention of diseases, preventing premature disposal of the animals.

  14. Tubal and peritoneal alterations diagnosed by hysterosalpingography; Alteraciones tubaricas y peritoneales diagnosticadas por histerosalpingografia

    Energy Technology Data Exchange (ETDEWEB)

    Monzon, M.; Ubeda, B.; Paraira, M.; Abuin, R. A.; Alert, E. [Institut Universitari Dexeus. Barcelona (Spain)

    2001-07-01

    In the evaluation of the multiple causes that contribute to infertility tubal and peritoneal factors are responsible for 25-40% of cases. Hysterosalpingography is the most reliable method in the evaluation of tubal morphology and patency, although it presents a lower sensibility in the assessment of pelvic adhesions. The purpose of this review is to describe the most frequent tubal and peritoneal abnormalities found in hysterosalpingography. We have reviewed the hysterosalpingography performed at our institution between January 1988 until December 1999 in patients undergoing evaluation for infertility, and the most representative images of the different pathologic entities have been chosen. (Author) 7 refs.

  15. Enfermidades diagnosticadas em bezerros na região sul do Rio Grande do Sul

    OpenAIRE

    2013-01-01

    O objetivo deste estudo foi relatar a frequência das enfermidades que ocorrem em bovinos até um ano de idade na área de influência do Laboratório Regional de Diagnóstico (LRD) da Faculdade de Veterinária da Universidade Federal de Pelotas (UFPel) estabelecendo os principais fatores epidemiológicos associados à ocorrência dessas enfermidades. Foram revisados os protocolos de necropsias realizadas e de materiais de bovinos até um ano de idade, encaminhados ao LRD/UFPel entre 2000 e 2011. Em 35,...

  16. Distrofias Musculares das Cinturas autossómicas recessivas diagnosticadas nos Hospitais da Universidade de Coimbra

    OpenAIRE

    Negrão, Luis; Geraldo, Argemiro; Rebelo, Olinda; MATOS, ANABELA; Santos, Rosário; Bronze-da-Rocha, Elsa

    2012-01-01

    Introduction Limb-girdle muscular dystrophies (LGMDs) are a hetero¬geneous group of muscle diseases. Autosomal dominant (LGMD1) and recessive (LGMD2) forms are recognized, each one with several subtypes. In Portugal there are no studies reporting the relative distribution of the different subtypes of LGMD2. Objective To determine the subtypes of LGMD2 diagnosed and their relative distribution at the Neurology Department of the Coimbra University Hospital. Material and Methods ...

  17. Proceso emocional y niveles de ansiedad en personas diagnosticadas de Trastorno de la Conducta Alimentaria

    OpenAIRE

    Azabal Sánchez, Beatriz

    2014-01-01

    Los trastornos de la Conducta alimentaria son una enfermedad que actualmente se ha extendido y está siendo más conocida, sobre todo la anorexia nerviosa o la bulimia. Por ello, existen más estudios y a su vez más terapias centradas específicamente en este tipo de trastorno, el cuál desencadena otros problemas en la persona, como puede ser la ansiedad. En este trabajo se lleva a cabo una investigación cuyo objetivo principal es analizar de qué manera influye el proceso de Arteterapia en el pro...

  18. Aspectos psicológicos de familiares de personas diagnosticadas con Trastorno del Espectro Autista (TEA

    Directory of Open Access Journals (Sweden)

    Violeta Adlai Hernández Martínez

    2012-01-01

    necesidades que se requieren cubrir dejan exhaustos a los involucrados, provocando cambios importantes en su vida. Por lo cual, se recomienda que reciban atención psicoterapéutica en distintas modalidades como psicoterapia individual y familiar. El presente trabajo describe algunas características de 100 casos de familiares de personas con tea que fueron atendidos en el Programa de Apoyo a Familiares de la Clínica de Autismo del Centro Integral de Salud Mental, en las modalidades de psicoterapia individual o familiar, durante el periodo comprendido entre junio de 2009 y agosto de 2010.

  19. Testování parametrizací složek dlouhovlnného záření v podmínkách malého šumavského povodí

    Czech Academy of Sciences Publication Activity Database

    Muller, J.; Dohnal, M.; Tesař, Miroslav

    Praha : Ústav pro hydrodynamiku, 2014 - (Brych, K.; Tesař, M.), s. 329-334 ISBN 978-80-02-02525-2. [Hydrologie malého povodí 2014. Praha (CZ), 22.04.2014-24.04.2014] R&D Projects: GA TA ČR TA02021451 Institutional support: RVO:67985874 Keywords : emissivity of air * water vapor pressure * nonlinear optimization * pyrgeometr * radiated longwave radiation * longwave radiation Subject RIV: DA - Hydrology ; Limnology

  20. Assessing the effects of global warming and local social and economic conditions on the malaria transmission Quantificando os efeitos do aquecimento global e das condições socioeconômicas locais na transmissão de malária

    Directory of Open Access Journals (Sweden)

    Hyun M Yang

    2000-06-01

    Full Text Available OBJECTIVE: To show how a mathematical model can be used to describe and to understand the malaria transmission. METHODS: The effects on malaria transmission due to the impact of the global temperature changes and prevailing social and economic conditions in a community were assessed based on a previously presented compartmental model, which describes the overall transmission of malaria. RESULTS/CONCLUSIONS: The assessments were made from the scenarios produced by the model both in steady state and dynamic analyses. Depending on the risk level of malaria, the effects on malaria transmission can be predicted by the temperature ambient or local social and-economic conditions.OBJETIVO: Apresenta-se um modelo matemático mostrando como esse instrumento pode ser importante para descrever a transmissão de malária. MÉTODOS: Baseado no modelo proposto previamente, foram quantificados os efeitos de dois fatores que podem afetar a transmissão da malaria: a temperatura ambiente e as condições socioeconômicas locais. RESULTADOS/CONCLUSÕES: A quantificação foi feita estudando o modelo proposto no estado estacionário e na sua dinâmica. Dependendo do nível de risco de malária, os principais efeitos na transmissão de malária são devidos à temperatura ambiente ou às condições socioeconômicas.

  1. Endometriose intestinal: uma doença benigna? Bowel endometriosis: a benign disease?

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    Marco Antonio Bassi

    2009-01-01

    Full Text Available A despeito do caráter benigno da endometriose, estima-se que 1% dos casos esteja relacionado com câncer, especialmente quando ambas as condições ocorrem nos ovários. Lesões extra-ovarianas encontradas no septo retovaginal, cólon, bexiga, vagina e peritônio da região pélvica também já foram associadas com neoplasias malignas. Várias características do tecido endometrial ectópico o aproximam do fenótipo neoplásico, e a própria endometriose possui comportamento tipicamente neoplásico com capacidade de invasão do estroma adjacente e associação com lesões à distância. Esta revisão atualiza conhecimentos diagnósticos, clínicos e terapêuticos dos implantes intestinais de tecido endometriótico, bem como sua relação com processos neoplásicos para melhor compreensão de seu caráter benigno ou de seu eventual potencial para malignidade.Endometriosis is generally assumed to be a benign disease, but it is estimated that 1% of cases are associated with cancer, especially when both conditions are present in the ovary. Extra-ovarian lesions in the rectovaginal septum, colon, bladder, vagina and peritoneum were already associated with malign neoplasia. Several characteristics of endometrial tissue are very similar to the neoplasia phenotype. Endometriosis itself typically behaves as a neoplasia process, spreading over adjacent stroma and being associated with distant lesions. This is an update on the diagnostic, clinical, and therapeutic knowledge of, management of bowel implants of endometrial tissue, as well as the relation with neoplastic processes to better understand its benign nature or eventual potential for malignancy.

  2. Enfermedades pleurales benignas inducidas por asbesto Benign pleural diseases induced by asbestos

    OpenAIRE

    J. Boldú; V. M. Eguía

    2005-01-01

    La exposición al asbesto es una causa importante de patología pleural y se puede producir con intensidades moderadas o ligeras dada la capacidad del asbesto de concentrarse en la pleura. Ello motiva junto a la prolongada latencia existente entre la exposición y la enfermedad, que sigamos viendo durante muchos años manifestaciones clínicas pleurales de exposición previa, a pesar del uso del asbesto cada vez más limitado en las últimas décadas. Dicha exposición puede presentarse con distintas m...

  3. Hipertrofia benigna do músculo masseter Benign masseter muscle hypertrophy

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    Daniel Zeni Rispoli

    2008-10-01

    Full Text Available A hipertrofia idiopática do músculo masseter (HIM é uma patologia pouco freqüente e de causa desconhecida. Alguns autores correlacionam tal condição com hábitos de mascar gomas, disfunção da articulação temporomandibular (ATM, hipertrofias congênitas e funcionais, e distúrbios emocionais (nervosismo e ansiedade. A maioria dos pacientes queixa-se da alteração estética decorrente da assimetria facial, também chamada "face quadrada", no entanto, sintomas como trismo, protrusão e bruxismo também podem ocorrer. Os objetivos deste estudo foram: relatar um caso de HIM e descrever a sintomatologia e o tratamento realizado. O paciente relatava aumento bilateral na região do ângulo da mandíbula de evolução lenta e progressiva. Negava dor ou desconforto, porém se queixava de otalgia bilateral, trismo noturno e ansiedade. Ao exame físico, observou-se hipertrofia bilateral de masseter sem alterações inflamatórias no local. Foi indicado tratamento cirúrgico com abordagem extra-oral. Exames complementares são indicados na dúvida diagnóstica. A conduta terapêutica varia de conservadora a cirúrgica, sendo que esta depende principalmente da experiência e da habilidade do cirurgião.Idiopathic hypertrophy of the masseter muscle is a rare disorder of unknown cause. Some authors associate it with the habit of chewing gum, temporo-mandibular joint disorder, congenital and functional hypertrophies, and emotional disorders (stress and nervousness. Most patients complain of the cosmetic change caused by facial asymmetry, also called square face, however, symptoms such as trismus, protrusion and bruxism may also occur. The goals of the present investigation were: to report a case of idiopathic masseter hypertrophy, describe its symptoms and treatment. The patient reported bilateral bulging in the region of the mandible angle, of slow and progressive evolution. He did not complain of pain or discomfort, however there was bilateral otalgia, nighttime trismus and stress. In his physical exam we noticed bilateral masseter hypertrophy without local inflammatory alterations. We indicated surgical treatment with an extraoral approach. Complementary tests are indicated when there is diagnostic doubts. Treatment varies from conservative to surgical, and the later depends on surgeon skill and experience.

  4. The Byzantines in Medieval Arabic Poetry: Abu Firas’ "Al-Rumiyyat" and the Poetic Responses of al-Qaffal and Ibn Hazm to Nicephore Phocas’ "Al-Qasida al-Arminiyya al-Malʿuna" (The Armenian Cursed Ode

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    Nizar F. HERMES

    2009-10-01

    Full Text Available Up until the Crusades, it was al-Rūm who were universally seen by Arab writers and Arab poets in particular as the Other par excellence. Nowhere is this more conspicuous than in the sub-genre of Al-Rūmiyyat (poems about the Byzantines, namely as found in the Rūmiyyat of Abu Firas al-Hamdani(d.968, and in the poetic responses of al-Qaffal(d. 946 and Ibn Hazm(d. 1064 to what was described by several medieval Muslim chronicles as Al-Qasida al-Arminiyya al-Malʿuna (The Armenian Cursed Ode. By exploring the forgotten views of the Byzantines in medieval Arabic poetry, this article purports to demonstrate that contrary to the impression left after reading Edward Said’s groundbreaking Orientalism: Western Conceptions of the Orient (1978 and other postcolonial studies, Orientals have not existed solely to be ‘orientalized’. Perhaps even before this came to be so, they too had ‘occidentalized’ their Euro-Christian Other(s in a way that mirrored in reverse the subject/object relationship described as Orientalism.

  5. Intervención familiar para el manejo psicológico en pacientes oncológicos con mal pronóstico en el hospital de la Misericordia

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    Ana Carolina Rodríguez Ibarra

    2004-01-01

    Full Text Available Se diseñó un programa fundamentado en el modelo cognitivo conductual de Inoculación de Estrés e intervención en duelo anticipatorio basado en cuatro tareas. El programa fue aplicado a tres pacientes con mal pronóstico del Servicio de Oncohematología del Hospital de la Misericordia y a sus familias. Por medio de estudio de caso, se describieron factores de riesgo y de protección así como respuestas frente a dicha intervención. El análisis cualitativo de casos arrojó la descripción de respuestas a pérdidas previas no elaboradas, pautas de comunicación deficiente en uno de los casos, y reconocimiento de apoyo al interior de cada familia. Según el reporte de los participantes, la intervención permitió la expresión de sentimientos, la reflexión sobre el sentido de la vida, incremento de posibilidades y habilidades de comunicación y orientación hacia la solución de problemas y toma de decisiones.

  6. Studie využití pomaloběžných větrných turbín pro malé a střední aplikace

    OpenAIRE

    Forró, Bálint

    2009-01-01

    Bakalářská práce se zabývá využitím pomaloběžných větrných turbín pro malé a střední aplikace, přesněji pak o Savonionův typ rotoru. V první části jsem se věnoval teoretickému využití větru a k analýze druhů větrných elektráren. V další části jsem zabýval popisem výhod a nevýhod Savonionova větrného rotoru a jeho praktickým využitím. Práci jsem zakončil konstrukčním návrhem větrného rotoru tohoto typu pro daný výkon při určité rychlosti větru. Bachelor’s thesis deals with usage of slow-run...

  7. Malaria vectors in the Brazilian Amazon: Anopheles of the subgenus Nyssorhynchus Anopheles do subgênero Nyssorhynchus, vetores da malária na Amazônia brasileira

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    Wanderli Pedro TADEI

    2000-04-01

    Full Text Available Various species of Anopheles (Nyssorhynchus were studied in the Amazon with the objective of determining their importance as malaria vectors. Of the 33 known Anopheles species occurring in the Amazon, only 9 were found to be infected with Plasmodium. The different species of this subgenus varied both in diversity and density in the collection areas. The populations showed a tendency towards lower density and diversity in virgin forest than in areas modified by human intervention. The principal vector, An. darlingi, is anthropophilic with a continuous activity cycle lasting the entire night but peaking at sunset and sunrise. These species (Nyssorhynchus are peridomiciliary, entering houses to feed on blood and immediately leaving to settle on nearby vegetation. Anopheles nuneztovari proved to be zoophilic, crepuscular and peridomiciliary. These habits may change depending on a series of external factors, especially those related to human activity. There is a possibility that sibling species exist in the study area and they are being studied with reference to An. darlingi, An. albitarsis and An. nuneztovari. The present results do not suggest the existence of subpopulations of An. darlingi in the Brazilian Amazon.Várias espécies de Anopheles (Nyssorhynchus foram estudadas na Amazônia a fim de se determinar sua importância na transmissão da malária. Das 33 espécies de Anopheles de ocorrência conhecida na Amazônia, apenas 8 foram encontradas infectadas por Plasmodium. O principal vetor, An. darlingi, é antropofílico com um ciclo contínuo de atividade que dura a noite inteira mas que tem picos ao anoitecer e ao amanhecer. As diferentes espécies desse subgênero variaram tanto em diversidade como em densidade nas áreas de coleta. A população de anofelinos apresentou tendências de menor densidade e diversidade em florestas virgens do que em áreas que sofreram intervenção humana. Essas espécies (Nyssorhynchus são peridomiciliares

  8. Eletromiografia laríngea e análise vocal em pacientes com Mal de Parkinson: estudo comparativo Laryngeal electromyography and acoustic voice analysis in Parkinson's disease: a comparative study

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    Ana Paula Zarzur

    2010-02-01

    Full Text Available A doença ou Mal de Parkinson se deve à deficiência dopaminérgica nos núcleos da base que geram alterações motoras. Comprometimento da comunicação verbal ocorre em 70 a 90% dos doentes. Existem poucas referências da aplicação da eletromiografia no estudo dos músculos laríngeos em pacientes com a doença de Parkinson. OBJETIVOS: Definir o padrão contrátil da musculatura intrínseca da laringe e sua correlação com a análise acústica vocal nos parkinsonianos. CASUÍSTICA E MÉTODO: Estudo prospectivo onde 26 adultos com o diagnóstico de Mal de Parkinson foram submetidos à eletromiografia laríngea e análise acústica vocal. Foram coletados potenciais de ação, tanto em repouso vocal quanto em fonação. Para a análise acústica da voz foram utilizados os programas VOXMETRIA® e GRAM 5.1.6®. RESULTADOS: O padrão eletromiográfico predominante no grupo estudo foi o de hipercontratibilidade (ou recrutamento aumentado durante repouso vocal que ocorreu em 73% dos indivíduos, sem que houvesse registro eletromiográfico de tremor. Quanto às características vocais, detectou-se a presença de tremor vocal no traçado do espectrograma (VOXMETRIA E GRAM e na avaliação perceptivo-auditiva em 69,5 % e 61 % dos sujeitos, respectivamente. CONCLUSÃO: O tremor vocal foi a característica acústica predominante no grupo estudado, sem que houvesse correlação eletromiográfica.Parkinson's disease (PD involves a progressive depletion of dopamine in the basal ganglia leading to motor alterations. Oral communication impairment occurs in 75% to 90% of patients and has been poorly studied. AIM: to asses laryngeal electromyography (LEMG patterns and correlate them to vocal analysis in patients with Parkinson's disease. MATERIALS AND METHODS: This is a prospective study. Twenty six adults with PD underwent laryngeal electromyography. Rest and phonation potentials were analyzed. VOXMETRIA® and GRAM 5.1.6. ® were used in acoustic analysis

  9. Resistência à mefloquina do tipo RIII em crianças com malária falciparum em Manaus, AM, Brasil RIII mefloquine resistance in children with falciparum malaria in Manaus, AM, Brazil

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    Elza Noronha

    2000-04-01

    Full Text Available Relata-se a ocorrência de resistência à mefloquina administrada na dose de 20mg/kg em 51 crianças com malária falciparum atendidas em centro de referência em Manaus, Brasil, no período de outubro a novembro de 1997. Todas as crianças foram avaliadas nos dias 3, 5, 7, 14, 21, 28 e 35 do tratamento, segundo critérios clínico e parasitológico. Foi encontrada uma incidência de resistência RIII de 5,9% (IC 95% variando de 1,5 a 17,2, a razão cura/resistência calculada foi 20:1 e cura/gravidade 62:1. Os dados chamam a atenção para a importância da resistência à mefloquina nesse grupo de crianças.We report the occurrence of resistance to mefloquine 20mg/day in 51 children with falciparum malaria treated, at reference center of Manaus, Brazil, from October to December 1997. All children were evaluated at day 3, 5, 7, 14, 21, 28 and 35 of treatment. Clinical and parasitological cure criteria were adopted. The incidence of RIII mefloquine resistance was 5.9% (IC 95% 1.5-17.2. The cure/resistance proportion was 20:1 and cure/severity was 62:1. These findings suggest the importance of mefloquine resistance within this group of children.

  10. Análisis integrado de factores genéticos, bióticos y abióticos para la formulación de una nueva hipótesis sobre la etiología del "mal del ciprés"

    OpenAIRE

    El Mujtar, Verónica A.

    2009-01-01

    El desarrollo de un trabajo de investigación en sistemas naturales plantea el desafío de avanzar en el conocimiento sorteando la dificultad de la falta de control sobre un conjunto de factores que pueden afectar las variables en estudio. La presente tesis tuvo como objetivo general el análisis simultáneo del mismo grupo de individuos desde diversos aspectos a fin de avanzar en la identificación de la etiología del o de los procesos actualmente englobados bajo la denominación mal del ciprés...

  11. Effects of immigration on the prevalence of malaria in rural areas of the Amazon basin of Brazil Conseqüência da imigração na prevalência da malária nas áreas rurais da bacia Amazônica no Brasil

    OpenAIRE

    Patrick B. Macgreevy; Reynaldo Dietze; Aluísio Prata; Stephen C. Hembree

    1989-01-01

    Epidemiological studies were conducted on malaria in three rural areas of the Amazon basin in the State of Rondônia: the town of Costa Marques, Forte Príncipe da Beira (Fort), and an immigrant settlement in the nearby forest. These studies were instituted to document the malaria problem and to describe the role of immigration on its distribution and prevalence. Hospital records in the town show that the number of malaria cases increased five fold from 1983 to 1987 and that the predominant mal...

  12. Blacasset, “Se·l mals d’amor m’auzi ni m’es noisens” (BdT 96.10a); Pujol, “Dieus es amors e verais salvamens” (BdT 386.2); Alaisina ~ Carenza, “Na Carenza al bel cors avenenç” (BdT 12.1 = 108.1)

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    Paolo Di Luca

    2012-01-01

    This paper provides a new critical edition of “Se·l mals d’amor m’auzi ni m’es noisens” by Blacasset and “Dieus es amors e verais salvamens by Pujol”. These two poets discuss a topic that is entirely new to Occitan lyric poetry: two young women about to enter a convent. While Blacasset expresses sadness about their choice of life in a convent, using elements of the funeral lament, Pujol praises it and believes it to be the only remedy for the corruption of the world. The tenso between women “...

  13. Vacinas em desenvolvimento: estreptococo do grupo B, herpes-zóster, HIV, malária e dengue Vaccines under development: group B streptococcus, herpes-zoster, HIV, malaria and dengue

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    Luiz Jacintho da Silva

    2006-07-01

    Full Text Available OBJETIVOS: As vacinas contra o estreptococo B, o herpes-zóster, o HIV, a malária e a dengue, selecionadas por critérios de comercialização iminente ou devido a problemas específicos para sua obtenção, foram objeto de uma revisão sobre o estado atual do seu desenvolvimento. FONTE DOS DADOS:Foi realizada revisão da literatura através da MEDLINE no período de 1996 a 2006, sobre a epidemiologia e imunologia das doenças, analisando tanto os maiores problemas para a obtenção de uma vacina como o estado atual dos estudos, com ênfase para os que estavam em fase mais adiantada. SÍNTESE DOS DADOS: Cada uma das cinco doenças escolhidas apresenta problemas específicos para o desenvolvimento de uma vacina. No entanto, a maioria deles já foi ou está em vias de ser resolvido, permitindo prever que uma vacina - ou vacinas - eficaz e segura estará disponível em futuro próximo. CONCLUSÕES:Apesar dos problemas enfrentados para o desenvolvimento dessas vacinas, os avanços da biologia molecular e da imunologia permitiram superar a maioria deles, abrindo a perspectiva para a obtenção de novas vacinas.OBJECTIVES: To review the current state of development of streptococcus B, herpes-zoster, HIV, malaria and dengue vaccines. These vaccines were selected both because of imminent commercial release and because of specific problems with their development. SOURCES OF DATA: A review of the literature was performed by means of a MEDLINE search, on the period 1996 to 2006, for the epidemiology and immunology of these diseases, analyzing both the greatest obstacles to creating a vaccine and the current state of research, with emphasis on studies in the most advanced stages. SUMMARY OF THE FINDINGS: Each of the five diseases chosen presents specific problems for vaccine development. Nevertheless, in the majority of cases these have been or are in sight of being resolved, allowing for the prediction that a safe and effective vaccine - or vaccines

  14. Mal-estar, sofrimento e sintoma: releitura da diagnóstica lacaniana a partir do perspectivismo animista Discontent, suffering and symptom: a Lacanian diagnostic re-reading via animist perspectivism

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    Christian Ingo Lenz Dunker

    2011-01-01

    Full Text Available O objetivo deste artigo é apresentar a noção de forma de vida como conceito útil para a recontextualização da diagnóstica psicanalítica, decorrente dos trabalhos de Jacques Lacan, no quadro da metadiagnóstica da modernidade, desenvolvida pelas teorias sociais, especialmente as de extração crítica. Para justificar a utilidade clínica e crítica do conceito de forma de vida vamos realizar uma redescrição das oposições fundamentais da diagnóstica psicanalítica (falta e excesso, produção e improdução, determinação e indeterminação, consideradas, respectivamente, como derivativos da esfera do desejo, da linguagem e do trabalho. Para tanto, propomos uma homologia entre a psicopatologia psicanalítica e a noção de perspectivismo ameríndio, desenvolvida por Viveiros de Castro (2002, que adquire neste trabalho uma dupla finalidade: 1 responder a críticas dirigidas ao estruturalismo lacaniano em psicopatologia; e 2 justificar a distinção entre sintoma, sofrimento e mal-estar.The objective of this article is to explore the notion of life form as a useful concept for recontextualizing psychoanalytic diagnosis, as inspired by the works of Jacques Lacan, within the framework of the metadiagnosis of modernity developed by social theories, especially those of a critical inclination. To justify the clinical and critical utility of the concept of life form, the text embarks on a re-description of the fundamental oppositions of psychoanalytic diagnosis (lack and excess, production and non-production, determination and indetermination as derived from the spheres of desire, language and work respectively. This aim in mind, the text proposes a homology between psychoanalytic psychopathology and the notion of Amerindian perspectivism developed by Viveiros de Castro (2002, which assumes a double purpose in this work: (1 to respond to critiques of Lacanian structuralism in psychopathology; and (2 to justify the distinction between

  15. O mal-estar no trabalho: a culpa como mal-estar e a culpa do mal-estar

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    Waldir Périco

    2011-01-01

    Full Text Available Este trabajo es una investigación teórica-reflexiva que busca, a la luz de la teoría psicoanalítica y Freud-marxista, pensar sobre el malestar en el local de trabajo - efectos de una civilización represiva -, así como sus posibilidades sublimatorias, en el contexto de los debates del conflicto individuo-civilización. El trabajo da al hombre la clave de su representación de sí y del mundo. Las investigaciones actuales demuestran la importancia de tomar en cuenta el trabajo para la comprensión del proceso salud/enfermedad tanto física como mental, así como la subjetividad del hombre de hoy. Sin embargo las organizaciones laborales, con un entendimiento reduccionista, y teniendo como cómplice el saber/poder médico-siquiátricos, tienden a ignorar su parte de responsabilidad en la "producción" de enfermedades entre los trabajadores, especialmente las relativas al psíquico. Freud, empezando com la comprensión de las neurosis, demonstro que en el conflicto individuo-civilización el primer paga un alto precio: el malestar constante (la culpa como malestar. Mientras que los dueños de la culpa, en el sentido social de la palabra (culpa del malestar, es la cultura humana, mediada por las organizaciones, que defienden los intereses de la minoria dueña de los medios de producción/explotación. Para Freud, el crecimiento de la culpa es inevitable dada la necesidad de la represión de las pulsiones para el progreso cultural através del trabajo desplaceroso. Sin embargo, Reich y Marcuse teorizan una salida para el pesimismo freudiano acerca del conflicto entre el individuo y la civilización. Freud no habría pesado adecuadamente la naturaleza sociohistórica del principio de la realidad, dada esta universal. Por lo tanto, el nivel de represión posee clase socioeconômica especifica: plusvalor para la minoria y plusrepresion para las grandes masas. Un principio de la realidad menos represivo podría proporcionar un progreso cultural más justo y humanizado. Sigue, como siempre, en el orden del día la posibilidad de trabajar en las condiciones sociales y psicológicas que permiten la reducción del malestar de las masas de trabajadores em el seno de la civilización.

  16. Malária e aspectos hematológicos em moradores da área de influência dos futuros reservatórios das hidrelétricas de Santo Antônio e Jirau, Rondônia, Brasil Malaria and hematological aspects among residents to be impacted by reservoirs for the Santo Antônio and Jirau Hydroelectric Power Stations, Rondônia State, Brazil

    OpenAIRE

    Tony Hiroshi Katsuragawa; Roberto Penna de Almeida Cunha; Daniele Cristina Apoluceno de Souza; Luiz Herman Soares Gil; Rafael Bastos Cruz; Alexandre de Almeida e Silva; Mauro Shugiro Tada; Luiz Hildebrando Pereira da Silva

    2009-01-01

    Em Rondônia, prevê-se a construção de mais duas usinas hidrelétricas (UHE) no rio Madeira, a montante da cidade de Porto Velho, Rondônia, Brasil (de Santo Antônio e Jirau). O objetivo deste trabalho foi analisar a prevalência da malária antes do início da implantação das obras civis e fazer considerações sobre os impactos da doença com o ingresso de milhares de trabalhadores e agregados atraídos pelas oportunidades de emprego e comércio. Os resultados obtidos mostram que a malária se faz pres...

  17. Alterações clínicolaboratoriais em pacientes com malária por Plasmodium vivax e deficiência de glicose-6-fosfato desidrogenase tratados com 0,50mg/kg/dia de primaquina Clinical and laboratorial alterations in Plasmodium vivax malaria patients and glucose-6-phosphate dehydrogenase deficiency treated with primaquine at 0.50mg/kg/day

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    Mônica C.M. Silva

    2004-06-01

    Full Text Available O efeito adverso da primaquina na dose de 0,50mg/kg/dia foi investigado em onze pacientes com malária vivax (três com deficiência de glicose-6-fosfato desidrogenase. Alterações clínicas e laboratoriais indicaram hemólise aguda apenas nos enzimopênicos, o que fez com que o tratamento fosse interrompido. Nossos resultados sugerem a necessidade do emprego de um teste de triagem para a deficiência de G6PD em áreas endêmicas de malária vivax a fim de se evitar complicações causadas pelo uso da primaquina.The adverse effects of primaquine (0.50mg/kg/day were investigated in eleven patients with vivax malaria (three patients with glucose-6-phosphate dehydrogenase deficiency. Clinical and laboratorial alterations indicated acute hemolysis in only the enzymopenic patients and treatment was interrupted. Our results suggest that screening for G6PD deficiency should be carried out in patients with vivax malaria infection in order to avoid complications due to primaquine.

  18. Réaction du polyisobutène chloré sur l'anhydride maléique : mécanisme. Catalyse par l'anhydride dichloromaléique Reaction of Chlorinated Polyisobutene on Maleic Anhydride. Mechanism. Catalysis by Dichloromaleic Anhydride

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    Sillion B.

    2006-11-01

    Full Text Available Dans cet article le mécanisme de la réaction de condensation du polyisobutène chloré sur l'anhydride maléique, qui sert dans la synthèse d'additif pour lubrifiant, est étudié par une cinétique globale et par un travail sur composés modèles. Il est montré que, dans cette réaction, l'anhydride maléique joue un double rôle : de catalyseur de déshydrochloration par une réactivité de type acide de Lewis organique, de réactif comme diénophile. Grâce à ces résultats, il est proposé une catalyse par l'anhydride dichloromaléique, qui permet une amélioration sensible du procédé. This article examines the mechanism of the chlorinated-polyisobutene condensation reaction on maleic anhydride. The overall kinetics and model compounds are investigated for this reaction which is used in the synthesis of lubricant additives. Maleic anhydride is shown to play the dual role of a dehydrochlorination catalyst by having a reactivity of the organic Lewis acid type and of a reactant like dienophile. These results are used to propose a catalysis by dichloromaleic anhydride which appreciably improves the process.

  19. Oxygen minimum seafloor ecological (mal) functioning

    Digital Repository Service at National Institute of Oceanography (India)

    Moodley, L.; Nigam, R.; Ingole, B.S.; PrakashBabu, C.; Panchang, R.; Nanajkar, M.; Sivadas, S.; van Breugel, P.; van Ijzerloo, L.; Rutgers, R.; Heip, C.H.R.; Soetaert, K.; Middelburg, J.J.

    variables control OM preservation in marine sediments is one of the most complex and controversial issues (Hedges et al. 1999; Burdige 2007; Zonneveld et al., 2009). The Arabian Sea with its permanent OMZ extending from 100 to 1200 meters water depth...; Arndt et al. 2009). Conform that the fraction of refractory OM is expected to increase with time resulting in the most resistant fraction being buried (e.g. Middelburg & Meysman 2007), longest OM half-life was found in subsurface sediment under...

  20. Dis-moi comment tu as mal ?

    OpenAIRE

    Mingard, Aurélie; Mothes, Coralie; Posse, Béatrice

    2015-01-01

    Nous avons choisi comme sujet d'étude l'évaluation de la douleur aux urgences pédiatrique grâce aux échelles d'évaluation. Nous argumentons notre problématique en regard des quatre concepts fondamentaux qui sont le soin, l'environnement, la personne et la santé.

  1. O mal-estar da Gerechtigkeit

    Directory of Open Access Journals (Sweden)

    Luís S. Krausz

    2008-11-01

    Full Text Available Der Fall Maurizius by Jakob Wassermann was first published in 1928. It is set partly in 1908 Germany and partly during the Weimar Republic. In this work, Wassermann criticizes German pragmatism by depicting the State bur eaucracy as the absolute power over citizens, even after the Imperial Era. Disgusted with the mismanagement of the justice system and with the perverse character of those in charge,  the author renders German pragmatism as non-adherence to the moral values supposedly justifying the State apparatus – in particular, as a breach of the Gerechtigkeit principle. The harmless innocence of the adolescent Etzel von Andergast, the only child of a well-known prosecutor,  highlights this violation of justice. At the same time, Waremme is a sinister character whose Jewish parents fled from Prussian-occupied Poland. He breaks with his ancestors’ moral values and is eager to play a key role in the German Nationalistic movement. However, he feels frustrated with his project of cultural assimilation and is pushed towards the outskirts of a bewildered society. The crisis of values and transgression of justice become the emblems of Wassermann’s generation. 

  2. Fenomena Mal Bagi Masyarakat Urban di Jakarta

    Directory of Open Access Journals (Sweden)

    Amarena Nediari

    2013-03-01

    Full Text Available Mall building is a place where urban communities come together with their specific interest. People go to the mall with their independent needs without any emotional bonding between each other. As a public space, mall is trying to meet the needs of urban communities especially as an entertaining space for the visitors. Go to the mall has become a way of life in urban society, as a destination for the whole family. While on the other hand the existence of many mall building are the traits of sick city, because as a public space, city does not meet the social and environmental objectives anymore. Jakarta has more than 75 building mall, it has exceeded the limit of the population. Mall has become a phenomenon because it has met the lifestyle of urban society but on the other side mall has spent water absorption area. This disagreement about mall building requires a mall that friendly to the environment, so that the green open spaces and water absorption area can be provided or replaced as well. The next discussion is about mall that should build friendly to the environment and its importance to the urban community.

  3. Malý aerodynamický tunel

    Czech Academy of Sciences Publication Activity Database

    Flídr, E.; Šafařík, P.; Trávníček, Zdeněk; Broučková, Z.

    Praha: GRADIENT, 2015 - (Ježek, J.; Nožička, J.; Adamec, J.; Šafařík, P.), s. 33-48 ISBN 978-80-86786-37-7. [Fluid mechanics and thermodynamics. Praha (CZ), 16.04.2015] R&D Projects: GA ČR GA14-08888S Institutional support: RVO:61388998 Keywords : small wind tunnel * flow field visualization Subject RIV: JU - Aeronautics, Aerodynamics, Aircrafts

  4. (MAL)practice of nuclear power economics

    International Nuclear Information System (INIS)

    Nuclear cost evaluations traditionally use the cost of concurrent coal-fired electricity as their benchmark, but these comparisons are now moot because cash-poor utilities aren't shopping for new power plants. A breakeven capital-cost ratio measures the capital cost handicap that a nuclear plant can stand and still break even with coal power by means of its fuel savings. Although different regions have different breakeven ratios, primarily due to variations in coal prices, a national average breakeven ratio can be placed between 1.2 and 1.4, meaning that nuclear plants could stand between a 20 and 40% higher capital cost and still end up with equal lifetime generating cost. The nuclear promoter's failure to represent costs competently and candidly show that there is a need for independent analysis of the economic and other consequences of major public investments. 24 references, 3 figures, 2 tables

  5. Mal de Debarquement (Sickness of Disembarkment)

    Science.gov (United States)

    ... ORG Did this free publication from VEDA help you? Thanks to VEDA , vestibular disorders are becoming recognized for their impacts on lives and our economy. We see new diagnostic tools and research studies, ...

  6. Analysis of refrigerant mal-distribution

    DEFF Research Database (Denmark)

    Kærn, Martin Ryhl; Elmegaard, Brian

    2009-01-01

    is developed in the object-oriented modeling language Modelica. The evaporator model is a dynamic distributed one-dimensional homogeneous model, but will be used here to present results in steady state. Fin-and-tube evaporators usually have a complex circuitry, however the evaporator will be simplified...

  7. Case 1432: MAL 8(1)

    DEFF Research Database (Denmark)

    Lookofsky, Joseph

    2014-01-01

    This publication reports a decision by the Supreme Court (Højesteret) of Denmark, 22 juni 2012 in case 210/2011 (1. afd.). Dregg v. Chr. Jensen Shipping. Published in Danish: Ugeskrift for Retsvæsen 2012 p. 3001 et seq. The decision relates to the U.N. Model Arbitration Law and the author of the...

  8. A ocorrência de malária em quatro municípios do estado do Pará, de 1988 a 2005, e sua relação com o desmatamento Occurrence of malaria in four cities in the state of Pará during 1988 to 2005 and its relationships with deforestation

    Directory of Open Access Journals (Sweden)

    Andressa Tavares Parente

    2012-03-01

    Full Text Available O objetivo deste trabalho foi estudar a ocorrência de malária em quatro diferentes regiões representativas do estado do Pará, buscando suas possíveis relações com as taxas de desmatamento. Foi realizado um estudo retrospectivo, com dados secundários, no período de 1988 a 2005, através de casos de malária registrados em quatro municípios do Estado (Anajás, Itaituba, Santana do Araguaia e Viseu, como também das taxas de desmatamento fornecidas pelo PRODES-INPE. Aplicou-se a técnica dos Quantis para se estabelecer cinco categorias ou classes de incidência da malária para cada município, sendo gerado posteriormente um IPA representativo para o Estado. De 1988 até 1994, as curvas de incidência de malária acompanham os números de desmatamento. A partir de 1995, evidenciaram-se anos consecutivos com altos índices de ocorrência da doença logo após os períodos de altas taxas de desmatamento, como registrado nos anos de 1995, 2000 e 2004. Percebeu-se que após a época de intenso desmatamento, os casos de malária variaram entre alto e muito alto no seu padrão de incidência, apontando que o desmatamento pode ser um fator de incremento na frequência e aumento no número de pessoas infectadas no estado do Pará.The purpose of this paper is to study occurrence of malaria in four different regions of the state of Pará and its possible relationships with deforestation rates. A retrospective study using secondary data from 1988 to 2005, using malaria incidence records reported in four cities in the state (Anajás, Itaituba, Santana do Araguaia and Viseu, as well as deforestation rates provided by the PRODES-INPE. The quantiles method was applied to establish five categories or classes of malaria incidence for each city, and a state IPA was generated with the contributions of these cities. From 1988 to 1994, the curves of incidence of malaria follow deforestation rates. From 1995, there are consecutive years of high incidence

  9. Posição viciosa de cabeça por astigmatismo mal corrigido: relato de caso Abnormal head position caused by incorrect prescription for astigmatism: case report

    Directory of Open Access Journals (Sweden)

    Flávia Augusta Attié de Castro

    2005-10-01

    Full Text Available A posição viciosa de cabeça é uma condição compensatória que visa proporcionar aos pacientes melhor rendimento visual. Pode ser causada por problemas oftalmológicos, como distúrbios oculomotores (nistagmos, estrabismos e altos astigmatismos. No entanto, compromete a estética e, a longo prazo, pode causar transtornos ortopédicos (coluna cervical e assimetrias faciais. Relatamos o caso de uma garota, JL, 8 anos, com cabeça inclinada para esquerda havia vários anos. Fazia uso de óculos prescritos em outro serviço para correção de astigmatismo misto: OD= +2,00 DE Ç -5,50 DC a 180º e OE= +2,25 DE Ç -5,75 DC a 180º. No exame oftálmico, a paciente apresentava cabeça inclinada para a esquerda e acuidade visual com correção de 0,5 no OD e 0,7 OE. Os testes de cobertura simples e alternado não evidenciaram desvio ocular. Rotações oculares, biomicroscopia e fundoscopia também não mostraram alterações. Na refratometria sob cicloplegia e teste de lentes foram encontrados: OD= +3,50 DE Ç -6,00 DC a 10º e OE= +3,50 DE Ç -6,00 DC a 170º, com acuidade visual igual a 1,0 nos olhos direito e esquerdo. Foram prescritas as lentes encontradas no exame e a paciente retornou com a correção nova sem a inclinação de cabeça. Erros refracionais mal corrigidos também podem gerar torcicolo e, muitas vezes, passam despercebidos. Refratometria sob cicloplegia e teste de lentes são fundamentais para um diagnóstico preciso.Abnormal head position is a compensatory condition which improves patients' vision. It can be caused by ophthalmological problems such as oculomotor imbalances (strabismus, nystagmus and high astigmatisms. However, it results in esthetic impairment, orthopedic trouble and facial asymmetries. We describe a case of a girl, JL, 8 years, with abnormal head position tilted to the left since the last glasses were prescribed. The correction used by the patient was: right eye = +2.00 sph à -5.5 cyl 180° and left eye = +2

  10. Doença de alzheimer e demandas de cuidados: o que os enfermeiros sabem? Mal de Alzheimer y demandas de cuidados: ¿Cuánto saben los enfermeros? Alzheimer diseases and care demands: what do nurses know?

    Directory of Open Access Journals (Sweden)

    Silvana Poltroniere

    2011-06-01

    Full Text Available O objetivo deste estudo foi desvelar o conhecimento de enfermeiros de unidades de internação clínica acerca da Doença de Alzheimer (DA e da demanda de cuidados de pacientes e familiares. Estudo descritivo-exploratório, com abordagem qualitativa. Os dados foram obtidos através de entrevista semi-estruturada. A saturação dos dados ocorreu com 11 enfermeiros de dois hospitais privados. Da análise de conteúdo, emergiram seis categorias: caracterização da DA, fatores de risco, formas de diagnóstico, complicações, medicações para tratamento, cuidados com doente e família. Observou-se que os enfermeiros possuem um conhecimento limitado sobre a DA, focando as ações de cuidado na alteração clínica que motivou a internação hospitalar. Reconhecem sinais e sintomas, mas se mostram como figuras coadjuvantes na assistência, quando deveriam posicionar-se de forma mais autônoma frente ao cuidado e à atenção à família.El objetivo de este estudio fue revelar el conocimiento de enfermeros de unidades de internación clínica sobre la Enfermedad o Mal de Alzheimer (EA y las exigencias del cuidado de los pacientes y sus familias. Estudio descriptivo exploratorio, con abordaje cualitativo. Los datos fueron obtenidos a través de entrevista semiestructurada. La saturación de datos se realizó con once enfermeros de dos hospitales privados. Del análisis de contenido, emergieron seis categorías: caracterización de la EA, factores de riesgo, formas de diagnóstico, complicaciones, medicación para tratamiento, cuidados con el enfermo y la familia. Se observó que los enfermeros poseen un conocimiento parcial sobre la EA, enfocando las acciones de cuidado en la alteración clínica que causó la internación hospitalaria. Reconocen señales y síntomas, pero se muestran figuras coadyuvantes en la asistencia, cuando deberían posicionarse de forma más autónoma frente al cuidado y a la atención a la familia.The aim of the present study

  11. Spoločenstvá suchozemských mäkkýšov severnej časti Devínskej Kobyly (Malé Karpaty

    Directory of Open Access Journals (Sweden)

    Jozef Šteffek

    2005-11-01

    Full Text Available Present paper is focused on two topics. First topic is focused on evaluation of mollusc assemblages of northern part of the Devínska Kobyla hill (Malé Karpaty Mts.. The second topic was evaluation of all published data on molluscs of this area. The research was conducted during vegetation period of the year 1978. From 9 types of biotopes altogether 47 quantitative samples were sampled. The assemblages were evaluated on the base of constancy and dominance of the species. Altogether 7913 mollusc specimens were obtained from the samples. Composition and status of the forest mollusc assemblages in northern part of the Devínska Kobyla was shown to be determined by the substratum, age of forest stand and the degree of the biotopes disturbance. The species richest assemblage was detected within old grown forest (biotope 7 and calcareous substratum. The species poorest were assemblages found within clear-cut and young stand (biotopes 5, 8. Species rich community was found also in old growth forest with quartzite substratum, however a number of steppe species is absent within this biotope. The molluscan communities of open habitats were observed only in the northern part of the Devínska Kobyla foothill area. They occur mainly within xeric degraded grassland biotopes (vacant pastures, deforested fields. Within other non-limestone substratum biotopes only species poor coenoses composed of single or e few of species occurred (biotopes 2 and 6. The exception was the natural xeric grassland biotopes, which were typical biotopes for rich community of steppe molluscs (biotope 9. Extremely rich were limestone rocks, which are in addition partially covered by forest. The rich forest land snail community together with a number of xeric species was found here (biotope 3. In second part mollusc species composition of northern and southern part of the Devínska Kobyla massive and the Devínske Hradné Bralo hill are compared. Altogether 65 mollusc species (51

  12. Controle da transmissão da malária em área de garimpo no Estado do Amapá com participação da iniciativa privada Control of malaria transmission in a gold-mining area in Amapá State, Brazil, with participation by private enterprise

    Directory of Open Access Journals (Sweden)

    Álvaro Augusto Couto

    2001-08-01

    Full Text Available Reportamos no presente trabalho a caracterização epidemiológica da malária, seguida da implantação de um programa de controle da endemia em uma área de garimpo, localizada ao norte do estado do Amapá. Considera-se a influência desta região no número total de casos do estado e o impacto da doença na população representada pelos funcionários e empreiteiros da Mineração Novo Astro S/A, bem como pela comunidade da Vila de Lourenço, Município de Calçoene, Amapá e garimpos adjacentes. O impacto das ações de controle adotadas no âmbito do programa, caracterizam-se pela significativa redução da incidência da malária na área e a redução da morbi-mortalidade. Ressalta-se a importância da participação da iniciativa privada, principalmente aquelas que desenvolvem projetos de grande porte na região Amazônica brasileira, no controle das endemias prevalentes na região, particularmente a malária.This paper reports on the epidemiological characterization of malaria following implementation of a program to control the endemic in a gold-mining area in northern Amapá State. The study focuses on total malaria cases in Amapá and the impact of the disease on the population, as represented by the Mineração Novo Astro S/A company and its employees as well as the community of Vila de Lourenço in the municipality of Calçoene, and adjacent gold miners. The effect of control measures in the program area is indicated by a significant reduction in malaria incidence and malaria-related morbidity and mortality. The importance of participation by private enterprise is emphasized, particularly in large projects for the control of endemic diseases (notably malaria in the Amazon Region.

  13. Malófagos (Phthiraptera recolhidos de aves silvestres no Zoológico de São Paulo, SP, Brasil Chewing lice (Phthiraptera from wild birds in the São Paulo Zoo, State of São Paulo, SP, Brazil

    Directory of Open Access Journals (Sweden)

    Michel P. Valim

    2005-12-01

    Full Text Available Vinte e oito espécies de malófagos foram recolhidas de aves silvestres no acervo do Zoológico de São Paulo durante o ano de 2003. Vinte e três foram identificadas ao nível de espécie e cinco ao nível genérico. Os relatos de novas espécies no Brasil e novas associações parasitárias para a literatura são discutidos.Twenty-eight species of chewing lice were recovered from wild birds in the São Paulo Zoo during 2003. Twenty-three were identified to species level and five to the generic level. New species records for Brazil and new host-lice associations are discussed.

  14. A utilização de uma rede neural artificial para previsão da incidência da malária no município de Cantá, estado de Roraima Use of an artificial neural network to predict the incidence of malaria in the city of Cantá, state of Roraima

    Directory of Open Access Journals (Sweden)

    Guilherme Bernardino da Cunha

    2010-10-01

    Full Text Available INTRODUÇÃO: A malária é uma doença endêmica na Amazônia Legal Brasileira, apresentando riscos diferentes para cada região. O Município de Cantá, no Estado de Roraima, apresentou para todo o período estudado, um dos maiores índices parasitários anuais do Brasil, com valor sempre maior que 50. O presente estudo visa à utilização de uma rede neural artificial para previsão da incidência da malária nesse município, a fim de auxiliar os coordenadores de saúde no planejamento e gestão dos recursos. MÉTODOS: Os dados foram coletados no site do Ministério da Saúde, SIVEP - Malária entre 2003 e 2009. Estruturou-se uma rede neural artificial com três neurônios na camada de entrada, duas camadas intermediárias e uma camada de saída com um neurônio. A função de ativação foi à sigmoide. No treinamento, utilizou-se o método backpropagation, com taxa de aprendizado de 0,05 e momentum 0,01. O critério de parada foi atingir 20.000 ciclos ou uma meta de 0,001. Os dados de 2003 a 2008 foram utilizados para treinamento e validação. Comparam-se os resultados com os de um modelo de regressão logística. RESULTADOS: Os resultados para todos os períodos previstos mostraram-se que as redes neurais artificiais obtiveram um menor erro quadrático médio e erro absoluto quando comparado com o modelo de regressão para o ano de 2009. CONCLUSÕES: A rede neural artificial se mostrou adequada para um sistema de previsão de malária no município estudado, determinando com pequenos erros absolutos os valores preditivos, quando comparados ao modelo de regressão logística e aos valores reais.INTRODUCTION: Malaria is endemic in the Brazilian Amazon region, with different risks for each region. The City of Cantá, State of Roraima, presented one of the largest annual parasite indices in Brazil for the entire study period, with a value always greater than 50. The present study aimed to use an artificial neural network to predict the

  15. Compensatory growth of Malaysian prawns reared at high densities during the nursery phase Crescimento compensatório em camarões-da-malásia cultivados sob altas densidades durante a fase de berçário

    Directory of Open Access Journals (Sweden)

    H.L.A. Marques

    2011-04-01

    Full Text Available The objective of this work was to verify the occurrence of compensatory growth in Malaysian prawn (Macrobrachium rosenbergii reared in pens, after being stocked in cages under high densities during nursery phase. The experiment was carried out in 0.5 m² cages and 2-m² pens set in natural bottom pond with 2,400 m². Prawn post-larvae (PL with an average weight of 0.026 ± 0.012 g (nursery phase were initially stocked in 16 cages at the densities of 50, 400, 800 and 1,200 PL m-2. Sixty days later, prawns were transferred to 16 growing pens, at the density of 12 prawns m-2. Initial average weight of the prawn in this phase was the final average weight registered in the nursery phase, as follows: 50 PL m-2 = 2.3 ± 0.3 g; 400 PL m-2 = 0.5 ± 0.03 g; 800 PL m-2 = 0.3 ± 0.05 g and 1,200 PL m-2 = 0.1 ± 0.01 g. Commercial rations for prawns (35% crude protein were given once a day, in the afternoon. After 244 days, survival, average weight and biomass did not differ significantly among prawns with different initial average weight. Relative growth rate was significantly greater in prawns previously stocked at 1,200 PL m-2 and feed conversion efficiency was significantly better for those previously stocked at 400 and 1,200 PL m-2. These results suggest the existence of partial compensatory growth in M. rosenbergii, what can successfully carry on stocking of prawns of this species at high densities in the nursery phase.Este trabalho foi realizado com o objetivo de verificar a ocorrência de crescimento compensatório em camarões-da-malásia (Macrobrachium rosenbergii cultivados em cercados, após serem estocados em gaiolas sob altas densidades durante a fase de berçário. O experimento foi conduzido em gaiolas com 0,5 m² e cercados com 2 m² instalados em um viveiro de fundo natural com 2.400 m². Pós-larvas (PL de camarões com peso médio de 0,026 ± 0,012 g (fase de berçário foram inicialmente estocadas em 16 gaiolas, nas densidades de 50, 400

  16. Hiperplasia Prostática Benigna e PSA: o efeito dominó Benign prostatic hyperplasia and PSA: the domino effect Hiperplasia benigna de prostata y PSA: el efecto dominó

    Directory of Open Access Journals (Sweden)

    José Agostinho Santos

    2012-12-01

    Full Text Available

    Após a publicação de uma recomendação contra o rastreio câncer prostático pela U.S. Preventive Services Task Force, a comunidade médica não poderá desvincular-se das particularidades relacionadas com o antígeno prostático específico (PSA. O enfoque dado às guidelines da Hiperplasia Prostática surge pela possível partilha, a determinado ponto da sua abordagem, de um trilho que cursa também com a solicitação do PSA. Os resultados de dois grandes ensaios clínicos constituem o maior corpo da evidência actual e deles sobressai que o número de homens que evitaram a morte por câncer prostático após submetidos ao rastreio foi reduzido. Há evidência de que 100-200 em 1000 homens rastreados terão um falso-positivo, a maioria dos quais será biopsada, com possíveis danos psicológicos e orgânicos. O Médico de Família deverá relembrar que não é recomendado que se ofereça esta análise, sem que primeiro discuta, juntamente com o paciente, as questões inerentes ao PSA.

    After U.S. Preventive Services Task Force published a recommendation against prostate cancer screening, the medical community cannot extricate itself from all specific features associated with the prostate-specific antigen (PSA. The focus given to the guidelines of the Prostatic Hyperplasia happens for the possible sharing of a certain point of its approach with the prostatic cancer case-finding, that is the PSA test. The results of two large clinical trials represent the largest body of evidence and they say the number of men who avoided prostate cancer death after subjected to screening was reduced. There is evidence that 100-200 in 1000 screened men will have a false-positive, most of which will have a biopsy with possible psychological damage and organic. The GP should remember that it is not recommended to provide this test, without first discussing together with the patient, the issues that are inherent to the PSA sample.

    Después de U.S. Preventive Services Task Force publicar una recomendación en contra el screening del cáncer de próstata, la comunidad médica no puede liberarse de todas las particularidades propias de lo antígeno prostático específico (PSA. La atención prestada a las directrices de la Hiperplasia Prostática aparece debido a posibilidad de compartir un cierto punto com el screening, que conduce a la petición del PSA. Los resultados de dos grandes ensayos clínicos representan el mayor cuerpo de evidencia y de ellos sobresale que el número de hombres que evitaron la muerte de cáncer de próstata después de someterse a el screening es reducido. Hay evidencia de que 100-200 en 1000 hombres sometidos a el screening tendrá un falso positivo, mayoría de los cuales será biopsada con posible daño psicológico y orgánico. El médico de família debe recordar que no se recomienda para proporcionar este estudio analítico, sin discutir primero junto con el paciente, los problemas que son inherentes en el PSA.

  17. Hiperplasia Prostática Benigna e PSA: o efeito dominó Benign prostatic hyperplasia and PSA: the domino effect Hiperplasia benigna de prostata y PSA: el efecto dominó

    OpenAIRE

    José Agostinho Santos

    2012-01-01

    Após a publicação de uma recomendação contra o rastreio câncer prostático pela U.S. Preventive Services Task Force, a comunidade médica não poderá desvincular-se das particularidades relacionadas com o antígeno prostático específico (PSA). O enfoque dado às guidelines da Hiperplasia Prostática surge pela possível partilha, a determinado ponto da sua abordagem, de um trilho que cursa também com a solicitação ...

  18. MULTIPLE LINEAR REGRESSION ANALYSIS OF GRAND MAL AND PETIT MAL FORMS OF EXPERIMENTAL EPILEPSY

    OpenAIRE

    Godlevsky, L.; Lobasyuk, B.; Kobolev, E.; Luijtelaar, E.L.J.M. van; COENEN A.R.M.L.; Stepanenko, K.; Haghoel, Raz; Prybalovetz, T.

    2005-01-01

    Relationships between amplitude of penicillin-induced generalized epileptiform signals in different zones of the brain cortex (occipito-frontal bilateral leads, as well as occipital and frontal bipolar leads) were investigated in Wistar rats using multiple linear regression method of analysis. Results were expressed in the form of policycle multigrafs (multidimensional presentation) with the identification of significant (p

  19. Criaturas bien nacidas aunque mal habidas y bien habidas aunque mal nutridas.

    OpenAIRE

    Grajales, Agustín

    2008-01-01

    Sur la base de 12 396 actes de baptême des fils légitimes, naturels et abandonnés de la paroisse de El Sagrario de la cathédrale de la ville de Puebla au cours de la décennie qui va de 1783 a 1792, on analyse les taux d'ilégitimité par groupe éthnique (entre huit et vingt pour cent) ainsi que le phénomène de l'abandon d'enfants. Celui-ci est effectué au seuil des portes et dans une moindre mesure dans l'hôpital d'enfants abandonnés dont on mentionne son origine et couverture. L'étude aborde l...

  20. 1929 Dünya Ekonomik Bunalımı Çerçevesinde Yerli Malı ve Tutum Haftası Kutlamaları Celebrations Of Domestic Goods And Economy Week In The Frame Of 1929 World Economic Crisis

    Directory of Open Access Journals (Sweden)

    Sevilay ÖZER

    2013-07-01

    şlanılan demiryolu imtiyazları takip etmiştir. Lakin gelinen noktada yerli üreticinin Avrupa malları karşısında zor durumda kalması daha o günlerde yerli malı kullanımını artırma düşüncesinin sıklıkla dile getirilmesine neden olmuştur. Bu söylem iç ve dış ticarette Türk-Müslüman unsurun hakimiyetini sağlamaya çalışan İttihat ve Terakki’nin, II. Meşrutiyet sonrasında liberalizmden koparak, millî iktisat politikasını hayata geçirmesiyle daha da artmış, Cumhuriyet’in ilk yıllarında uygulamaya konulan birtakım kararlarla devam ettirilmeye çalışılmıştır. Ancak 1929 dünya ekonomik buhranı ile içine girilen zor süreçte, yerli malı ve tasarruf anlayışına karşı daha ciddi bir yaklaşım sergilenmek durumunda kalınmıştır. İlk iş olarak Millî İktisat ve Tasarruf Cemiyeti kurulmuş ve her yıl Aralık ayının 12 ile 19’u arasındaki yedi günün “Yerli Malı ve Tutum Haftası” olarak kutlanması kararlaştırılmıştır. Söz konusu kutlamalar; mekteplerden halkevlerine, camilerde okunan hutbelerden yerli malı satan müesseseler arasında yapılan vitrin yarışmalarına kadar pek çok farklı uygulamayı içine alacak şekilde yapılarak, hem halk nezdinde yerli malının hak ettiği itibarı kazanması sağlanmaya çalışılmış, hem de mali anlamda ülke ekonomisine destek olunmak istenmiştir.

  1. Mal posición de tornillos pediculares lumbares que producen radiculalgia mecánica postoperatoria con estimulación neurofisiológica intraoperatoria normal: el valor de la estimulación neurofisiológica del trayecto del tornillo

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    Vicente García González

    2013-12-01

    Full Text Available OBJETIVO: Valorar una exploración neurofisiológica que identifique estos casos intraoperatoriamente y evite la mal posición de tornillos pediculares. MÉTODOS: En 293 pacientes intervenidos de escoliosis por vía posterior con tornillos pediculares y técnica "free hand", se implantaron 6.739 tornillos. De estos, ocho pacientes (2,7%, con edad promedio de 24 años, presentaron dolor radicular lumbar postoperatorio. En la TC postoperatoria se encontraron 10 tornillos lumbares (2L1-3L2-4L3-1L4 con prominencia mínima en la parte inferior del pedículo. Se evaluaron los umbrales de EMG del tornillo y del trayecto. RESULTADOS: En cirugía inicial no se detectaron anomalías en la palpación del trayecto, ni en el control radioscópico, ni alteraciones neurofisiológicas en la estimulación neurofisiológica con t-EMG. Todos presentaron dolor radicular en bipedestación y sedestación que remitía con reposo en cama. Los tornillos fueron retirados quirúrgicamente a los 37 días en promedio (R:4-182. En esta cirugía se repitió la monitorización neurofisiológica y volvió a mostrar valores normales (> 11mA. Tras la retirada de los tornillos, se realizó estimulación del trayecto que mostró en la parte media, umbrales por debajo de los valores normales (3,9-10,7mA. Tras un seguimiento promedio de 4,4 años (R:2,6-6.8, cinco pacientes referían tener molestias radiculares ocasionales y uno tenía déficit motor mínimo en la extremidad afectada. CONCLUSIONES: Se presenta un tipo de mal posicionamiento de tornillo pedicular lumbar que produce radiculalgia en bipedestación-sedestación y que no es detectado con monitorización convencional. La estimulación neurofisiológica del trayecto en la zona media, tras retirada del tornillo pedicular, produjo umbrales bajos de estimulación. Se recomienda estimulación sistemática del trayecto antes de la inserción del tornillo pedicular lumbar.

  2. Valor predictivo de la estimulación eléctrica de los tornillos pediculares torácicos en la mal posición medial de los mismos en la instrumentación de cirugía de columna Valor preditivo da estimulação elétrica em casos de mal posicionamento de parafusos pediculares torácicos na cirurgia de coluna Predictive value of electrical stimulation in cases of malposition of thoracic pedicle screws in spine surgery

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    Pedro Cortés García

    2012-06-01

    Full Text Available OBJETIVO: Demostrar si la técnica de estimulación eléctrica permite la detección de la mal posición medial de los tornillos pediculares torácicos. RESULTADOS: Se analizaron 421 tornillos torácicos. Tuvimos alertas a la estimulación en 25 (5,93% de los casos. A todos los pacientes se les realizó radiografía posoperatoria demostrando 22 tornillos (5,2% medializados. Realizamos TAC en 17 pacientes (37%, con ningún tornillo en posición 1 y 10 tornillos en posición 2 (8,5%. Se consideraron tornillos medializados los que tenían respuesta positiva a estimulación inferior a 6 mA. CONCLUSIONES: la estimulación eléctrica nos ha permitido reducir el riesgo de posición medial de los tornillos torácicos, minimizando además el uso de radiografía intraoperatoria.OBJETIVO: Demonstrar se a técnica de estimulação elétrica permite a detecção de mal posicionamento medial dos parafusos pediculares torácicos. RESULTADOS: Foram analisados 421 parafusos torácicos. Os alertas da estimulação ocorreram em 25 (5,93% dos casos. Todos os pacientes foram submetidos à radiografia pós-operatória que demonstrou 22 parafusos (5,2% medializados. Realizamos TC axial em 17 pacientes (37%, e não se encontrou nenhum parafuso na posição 1, sendo que 10 parafusos estavam na posição 2 (8,5%. Foram considerados parafusos medializados os que apresentaram resposta positiva à estimulação inferior a 6 mA. CONCLUSÕES: a estimulação elétrica permitiu a redução de risco de posição medial dos parafusos torácicos, minimizando o uso de radiografias intraoperatórias.OBJECTIVE: To demonstrate that the electrical stimulation technique allows the detection of medial malpositioning of thoracic pedicle screws. RESULTS: We analyzed 421 thoracic screws. Stimulation alerts occurred in 25 (5.93% cases. All patients underwent postoperative radiographs showing 22 medialized screws (5.2%. Axial CT scans were performed on 17 patients (37%, and no screw was

  3. Aspectos de imagem na tendinite calcária pré-vertebral

    OpenAIRE

    Caio Giometti Grassi; Fábio de Vilhena Diniz; Márcio Ricardo Taveira Garcia; Regina Lúcia Elia Gomes; Mauro Miguel Daniel; Marcelo Buarque de Gusmão Funari

    2011-01-01

    A tendinite calcária aguda pré-vertebral é uma condição benigna e rara que apresenta calcificação das fibras do músculo longo do pescoço com reação inflamatória local, sendo esta uma das formas de apresentação menos frequentes da doença por deposição de hidroxiapatita de cálcio. Manifesta-se com dor cervical aguda e/ou odinofagia, podendo ser erroneamente diagnosticada como abscesso retrofaríngeo, espondilodiscite ou alteração decorrente de trauma. Os achados radiológicos na tendinite calcári...

  4. Antropometria e perfil lipídico em mulheres com câncer de mama: um estudo caso-controle

    OpenAIRE

    Karine Anusca Martins; Ruffo Freitas-Junior; Estelamaris Tronco Monego; Régis Resende Paulinelli

    2012-01-01

    OBJETIVO: avaliar a composição corporal e o perfil lipídico de mulheres com e sem câncer de mama. MÉTODOS: estudo caso-controle pareado por idade, incluindo 62 mulheres, sendo 31 recém-diagnosticadas com câncer de mama e 31 com alterações mamárias benignas. Os dados foram coletados por meio de entrevista direta, com caracterização sociodemográfica, avaliação da composição corporal por antropometria, incluindo dobras cutâneas (DC) e circunferências, bioimpedância (BIA) e ultrassonografia (USG)...

  5. Blacasset, “Se·l mals d’amor m’auzi ni m’es noisens” (BdT 96.10a; Pujol, “Dieus es amors e verais salvamens” (BdT 386.2; Alaisina ~ Carenza, “Na Carenza al bel cors avenenç” (BdT 12.1 = 108.1

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    Paolo Di Luca

    2012-09-01

    Full Text Available This paper provides a new critical edition of “Se·l mals d’amor m’auzi ni m’es noisens” by Blacasset and “Dieus es amors e verais salvamens by Pujol”. These two poets discuss a topic that is entirely new to Occitan lyric poetry: two young women about to enter a convent. While Blacasset expresses sadness about their choice of life in a convent, using elements of the funeral lament, Pujol praises it and believes it to be the only remedy for the corruption of the world. The tenso between women “Na Carenza al bel cors avenenç” seems to be conceived as a parody of this lyric debate: in the dialogue Alaisina and Yselda, who have doubts about becoming mothers, ask Na Carenza whether it is better to stay virgins or to marry; the latter advises them, in cryptic terms that are difficult to interpret, to become nuns, thereby gaining a husband (God but not children. I will suggest that the question of female authorship for this text be reconsidered, while proposing a new interpretation in the light of the lively debate in the medieval period about the suitability and prerogatives of virginity.

  6. Análise da freqüência de recaídas de malária por Plasmodium vivax em região não endêmica (São Paulo, Brasil Analysis of the frequency of relapses due to malaria caused by Plasmodium vivax in a non endemie area (São Paulo, Brazil

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    Marcos Boulos

    1991-04-01

    Full Text Available Em virtude da existência de poucas informações, devidamente registradas, sobre freqüência e épocas de recaídas de malária por Plasmodium vivax, contraída no Brasil, foi analisada casuística observada em região não endêmica e constituída por pacientes corretamente tratados. O índice de recaídas documentadas em São Paulo, foi alto (24,5%, com desenvolvimento precoce na maioria das oportunidades, ou seja, em tempo inferior a três meses.Very few well-established information is available about the frequency and timeliness of relapses in cases of Plasmodium vivax malaria acquired in Brazil. So, we analysed a series of correctly treated patients observed out of endemic areas. The rate of relapses seen in São Paulo, which may represent that of the parasitosis in the whole country, was high, ranging from 7.5% to 24.5%, and early in most cases, i.e. appearing by three months, what anticipates a high endemicity.

  7. Využití stabilních izotopů vodíku a kyslíku v hydrologii malých experimentálních povodí České a Slovenské republiky

    Czech Academy of Sciences Publication Activity Database

    Šanda, M.; Vitvar, T.; Holko, L.; Blažková, Š.; Bůzek, F.; Císlerová, M.; Fottová, D.; Kostka, Z.; Kulasová, A.; Kvítek, T.; Šnytr, O.; Tachecí, P.; Tesař, Miroslav; Vícha, Z.; Žlábek, P.

    Praha : Ústav pro hydrodynamiku AV ČR, v. v. i, 2011 - (Šír, M.; Tesař, M.), s. 419-435 ISBN 978-80-02-02290-9. [Hydrologie malého povodí 2011. Praha (CZ), 08.03.2011-10.03.2011] R&D Projects: GA MŽP SP/1A6/151/07; GA ČR GA205/08/1174 Grant ostatní: GA ČR(CZ) GA205/09/0831; MŽP(CZ) SP/2E7/229/07; AOPK ČR(CZ) AOPK ČR PPK 21a/52/10; GA MZe(CZ) QH82095; IAEA(AT) IAEA 14007; IAEA(AT) IAEA CRP F3.30.15; AOPK ČR(CZ) AOPK ČR PPK 42a/52/10 Institutional research plan: CEZ:AV0Z20600510 Keywords : stable water isotopes * experimental catchment * water residence time * runoff generation Subject RIV: DA - Hydrology ; Limnology

  8. Spatial analysis for stratification of priority malaria control areas, Mato Grosso State, Brazil Análise espacial na estratificação de áreas prioritárias para o controle da malária no Estado de Mato Grosso, Brasil

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    Marina Atanaka-Santos

    2007-05-01

    Full Text Available The goal of this study was to stratify priority areas for malaria control in the State of Mato Grosso, Brazil, based on spatial analysis. The variables used were: Annual Parasite Index (API, Plasmodium falciparum/Plasmodium vivax ratio, population variation, number of families settled, and percent of deforested area. The Moran's I and Local Moran Test were applied, visualized with the Box Map and Moran Map, for 1986- 1991, 1992-1997, and 1998-2003. Box Map identified areas with high, low, and intermediate priority for control, and Moran Map identified municipalities with significant autocorrelation. In the high priority area, located in the North of Mato Grosso, malaria incidence decreased drastically despite the increase in the number of municipalities from the first to the last period. Other municipalities were added to the lower priority area, from the Southeast, Southwest, and Central-South of the State. The intermediate priority area was located along the border with neighboring States and municipalities classified as high and low priority. Spatial analysis showed the importance of the neighboring phenomenon between municipalities in defining priority areas, thus highlighting the technique's advantages for use in malaria control and surveillance.Pautado em técnicas de análise espacial, analisou-se a estratificação de áreas prioritárias para controle da malária no Estado de Mato Grosso, Brasil. Trabalhou-se Incidência Parasitária Anual, relação Plasmodium falciparum/Plasmodium vivax, variação populacional, número de famílias assentadas e percentuais da área desmatada. Foram utilizados os testes de I de Moran e Moran Local, visualizadas pelo Box Map e Moran Map, nos períodos de: 1986 a 1991, 1992 a 1997 e 1998 a 2003. Pelo Box Map identificaram-se áreas de prioridade maior, menor e intermediária, e pelo Moran Map localizaram-se municípios com autocorrelação estatisticamente significante. Na área de maior prioridade

  9. Uso do sensoriamento remoto para estudar a influência de alterações ambientais na distribuição da malária na Amazônia brasileira Use of remote sensing to study the influence of environmental changes on malaria distribution in the Brazilian Amazon

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    Cíntia Honório Vasconcelos

    2006-03-01

    Full Text Available A construção da hidroelétrica de Tucuruí, no sudeste do Estado do Pará, Brasil, em 1981, impôs grandes mudanças ambientais, desmatamentos e migração para a região. O objetivo deste trabalho é verificar a influência destas mudanças na ocorrência da malária no Município de Jacundá, Pará, Brasil, utilizando-se técnicas de sensoriamento remoto e sistemas de informações geográficas. Os parâmetros utilizados para a construção dos mapas foram: distância das estradas, classe agrossilvopastoril, distância de coleções hídricas (rios, igarapés e do reservatório e da área urbana do município. Neste estudo, verificou-se o caráter epidêmico da malária a partir da construção da barragem de Tucuruí. Sugere-se que o padrão sazonal da incidência está relacionado com o período de maior estabilidade das margens do reservatório e ocorrência de áreas alagadas, além de maior exposição de trabalhadores na época de colheita na região. Foi observado que a distribuição dos casos está relacionada com as formas de uso e ocupação da terra, principalmente em áreas de maior influência das estradas, locais onde se concentra grande parte da população.Construction of the Tucuruí hydroelectric dam in Southeast Pará State, Brazil, in 1981, caused enormous environmental changes, deforestation, and human migration to the region. This study focuses on the influence of these changes and the appearance of malaria in the municipality of Jacundá, Pará, using remote sensing and geographic information systems. The variables used to construct maps were distances from roads, farming areas, rivers, the dam, streams, and the urban area. This study confirmed the elevation of malaria to the epidemic level since the construction of the Tucuruí dam. The study suggests that a seasonal pattern of malaria incidence is associated with the flooding season and exposure of workers during harvest. Malaria cases were related to the form of

  10. Aspectos da transmissão focal de malária na Ilha de São Luis, Maranhão Aspects of the focal transmission of malaria in the Island of São Luis, Maranhão

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    Antônio Rafael da Silva

    2006-06-01

    Full Text Available O estudo foi desenvolvido com o objetivo de caracterizar um foco de transmissão de malária em Guarapiranga, município de São José de Ribamar, MA. A unidade de estudo foi o grupo familiar, aplicando-se questionário sobre identificação, situação econômica, hábitos dos moradores e características dos domicílios. Foram visitadas 54 famílias, totalizando 207 habitantes, sendo 113 do sexo masculino e 95, do feminino. 95 pessoas tinham de 5 a 24 anos. Agricultura e pesca são a base da economia local, com 64,8% das famílias auferindo renda mensal menor que um salário mínimo. A maioria das casas é construída de taipa, coberta de palha, tem piso de chão batido e não tem instalações sanitárias. Em relação à entrada de mosquitos, 62,2% são parcialmente protegidas. A água para consumo provém de cacimbas ou poços rasos em 78,8%, e o lixo é deixado a céu aberto em 53,7% dos domicílios. Foram registrados 106 casos de malária por Plasmodium vivax. O provável transmissor foi o Anopheles (N aquasalis e o tratamento com cloroquina associado à primaquina teve bons resultados.The aim of the study was to typify a malaria focus in Guarapiranga, in the district of São José de Ribamar, MA. A questionnaire regarding identification, economic situation, habits of the residents and characteristic of the residences was applied to each family. Fifty four families were visited and 207 inhabitants were interviewed (113 men and 95 women; 95 individuals were aged between 5 and 24 years old. Agriculture and fishing are the basis of the local economy; 64.8% of the families earn less than one living wage. The majority of the residences are constructed of mud walls, straw roofs, a beaten earth floor, with no basic sanitation. 62.2% of the residences are partially protected against the entry of mosquitoes. Water for domestic use comes from natural waterholes in 78.8% of the residences. Rubbish is left in the open air in 53.7% of the residences

  11. Conhecimentos, práticas e percepções de profissionais de saúde sobre o tratamento de malária não complicada em municípios de alto risco da Amazônia Legal Uncomplicated malaria treatment in the Brazilian Amazon: knowledge, practices and perceptions of health workers in high-incidence municipalities

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    Claudia Garcia Serpa Osorio-de-Castro

    2011-01-01

    Full Text Available O controle da malária no Brasil conta com diagnóstico precoce e tratamento adequado e oportuno como estratégia para cura rápida e duradoura. Consequências clínicas e resistência aos antimaláricos podem resultar de falhas na prescrição, dispensação e aceitação dos profissionais aos esquemas terapêuticos propostos. Objetivou-se avaliar conhecimentos, práticas, percepções e atitudes de profissionais envolvidos na assistência farmacêutica à malária, frente ao protocolo oficial e a possíveis falhas na terapêutica. Entrevistaram-se profissionais em seis municípios na Amazônia Legal. Utilizou-se técnica de análise do discurso para determinação de categorias analíticas e sistematização. Dos 63 entrevistados, houve apenas um médico. Os demais, de nível médio, atuavam no diagnóstico, indicação e dispensação do tratamento antimalárico. O tempo de formação e de treinamento foi variável. Houve falhas na adesão ao protocolo nacional, perpassando indicação, dispensação e orientação aos pacientes. Os profissionais carecem de conhecimento para lidar com as especificidades da doença e do tratamento. A responsabilização de profissionais que não possuem o preparo necessário para a atenção sugere necessidade de políticas para a adequada capacitação e incorporação de recursos humanos.Malaria control in Brazil is based on early diagnosis and adequate and timely treatment as strategies for a rapid and long-lasting cure. Clinical consequences and resistance to antimalarials may arise from problems in prescribing, dispensing and in acceptance of therapeutic regimens by healthcare workers. We studied knowledge and practices, perceptions and attitudes of health workers participating in pharmaceutical services for malaria, regarding the official protocol and the possible flaws in therapy. Health workers from six municipalities in the Brazilian Amazon were interviewed. Speech analysis was employed as a technique

  12. Estudo sobre a eventual utilidade de raios gama na profilaxia da malária transmissível por transfusão de sangue A study on the fortuitons advantage of gamma irradiation in the prophylaxis of transmissible malaria by blood transfusion

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    Lúcia Maria Almeida Braz

    1998-12-01

    Full Text Available O estudo foi realizado com o objetivo de avaliar a eventual utilidade de raios gama na profilaxia da malária transmissível por transfusão de sangue, tendo sido, para isso, usados camundongos infectados pelo Plasmodium berghei. Na primeira fase, quando submetemos sangue deles retirado a 2.500 e 5.000rad, com associação ou não de metronidazol, não obtivemos sucesso, já que todos os animais antes sem a parasitose apresentaram parasitemia e morreram após inoculação do sangue irradiado. Porém, ocorreu êxito parcial na segunda fase, ao serem empregados 10.000 e 15.000rad, porquanto 20% e 40% dos roedores, respectivamente, embora tenham ficado infectados, sobreviveram, com posterior negativação quanto à presença do P. berghei.This study was carried out to evaluate the fortuitons advantage of using gamma irradiation in the prophylaxis of transmissible malaria by blood transfusion, with mice as the experimental model. In the first step, when the infected blood with Plasmodium berghei was submitted to 2,500rad and 5,000rad, with or without metronidazol, there was no success, because the animals presented parasitaemia and died after inoculation of irradiated blood. However, there was partial success in the second step, when the infected blood received 10,000 and 15,000rad, and was inoculated in mice, which showed infection, and presented a survival rate of 20% and 40%, respectively, with later negativation of blood infected by P. berghei.

  13. Aplicación de terapia de presión negativa en un caso de pioderma gangrenoso

    OpenAIRE

    P. Martín-Playá; R. Tarragona-Fernández; M. Ballestero-Diez; E. Vicario-Elorduy; J.J. García-Gutiérrez

    2015-01-01

    El pioderma gangrenoso es una enfermedad cutánea de etiología desconocida. Las lesiones comienzan típicamente como pústulas o nódulos de rápida evolución hacia úlceras profundas, mal determinadas y violáceas. El fenómeno de patergia está presente en un 20-50% de los casos, por lo que el desbridamiento de las lesiones conduce a un recrudecimiento del cuadro. Presentamos el caso de una paciente diagnosticada de pioderma gangrenoso en la cual, debido a la lenta evolución con inmunosupresores sis...

  14. Aspectos sócio-econômicos dos indivíduos com malária importada na região metropolitana de São Paulo, Brasil: I - Caracterização da população e conhecimento sobre a doença Social and economic aspects of patients with imported malaria in the metropolitan region of S. Paulo City, S. Paulo State, Brazil: I - Characterization of the population and knowledge of the disease

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    Maria José Chinelatto Pinheiro Alves

    1990-08-01

    Full Text Available Com o objetivo de conhecer o perfil sócio-econômico dos indivíduos que se deslocaram das áreas endêmicas de malária do país, foram estudadas 566 pessoas com suspeita de malária que procuraram a confirmação diagnostica no Laboratório de Malária da Região Metropolitana de São Paulo da Superintendência de Controle de Endemias (SUCEN. As informações foram obtidas através da aplicação de formulário, no período de novembro de 1986 a junho de 1987. Da população estudada, 345 (61,0% residiam na área endêmica, 479 (84,6% eram do sexo masculino, 513 (90,7% estavam na faixa etária de 15 a 55 anos e 307 (54,2% apresentaram hemoscopia positiva para plasmódio. Com relação à ocupação na área de transmissão, observou-se que 109 (19,3% estavam ligados a atividade de extração de minerais, 74 (13,2% à agricultura e 46 (8,1% à atividade de transporte. A análise da escolaridade mostrou que 486 (85,9% tinham 1° ou 2° grau. Quanto ao conhecimento sobre a doença, 384 (67,8% declararam pelo menos 1 malária anterior e 491 (86,8% associavam à doença a presença do vetor. Dentre os 221 indivíduos residentes em São Paulo, 207 (93,7% conheciam o risco de contrair malária por ocasião do deslocamento para área de transmissão. Daqueles residentes na área endêmica, 336 (97,4% tinham conhecimento do risco de contrair a doença naquela região. O intervalo transcorrido entre os primeiros sintomas e a procura de atendimento médico em 386 (68,2% indivíduos variou de 0 a 3 dias. As freqüências das variáveis estudadas mostraram de acordo com o resultado hemoscópico e o local da residência, diferenças estatísticas relevantes.With a view to discovering the social and economic characteristics of people from endemic malarial areas of Brazil, 566 suspected malaria cases were studied at the S. Paulo City Metropolitan Region Malaria Laboratory. Data were obtained by means of the application of standardized questionnaires over the

  15. Variação da densidade anofélica com o uso de mosquiteiros impregnados com deltametrina em uma área endêmica de malária na Amazônia Brasileira Variation of anopheles density with deltamethrin-impregnated mosquito nets in an endemic malaria area of the Brazilian Amazon

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    João Barberino Santos

    1999-04-01

    Full Text Available Em 1992, foi realizado um ensaio de campo com mosquiteiros impregnados com deltametrina, em uma área endêmica de malária no Município de Costa Marques, Rondônia. No período de baixa transmissão, os mosquiteiros impregnados (MI diminuíram a densidade vetorial no intradomicílio, de modo semelhante, porém, aos mosquiteiros não impregnados (NI na maioria das avaliações-controle. Por outro lado, na época de alta transmissão, os MI provocaram diminuição significante da média horária de anofelinos capturados, ao passo que, nas casas com NI, verificou-se aumento do número de mosquitos capturados. No peridomicílio, em geral, não houve diferença do número de anofelinos capturados entre MI e NI. No grupo MI, a espécie mais capturada foi o An. darlingi (63,2%, mais freqüente no peridomicílio, seguida pelo An. deaneorum (35,3%, mais freqüente no intradomicílio. Os MI diminuíram a densidade vetorial no intradomicílio pelo efeito excito-repelente, sem diminuí-la, contudo, no peridomicílio.In 1992 a survey on the use of deltamethrin-impregnated mosquito nets was conducted in the municipality of Costa Marques, Rondonia. In the intradomicile, impregnated nets decreased the vector density at rates similar to those for non-impregnated nets during low-transmission periods; during high anopheline density periods, they led to a significant reduction in vector density, while in the non-impregnated net group there was an increase in the number of anophelines captured. There was no change in vector density in the peridomicile. In the impregnated net group, the most frequently captured species was Anopheles darlingi (63.2%, found mostly in the peridomicile, while Anopheles deaneorum (35.3% was most frequent indoors. The impregnated mosquito nets' excitatory-repellent effect decreased the intradomiciliary vector density but did not alter density in the peridomicile.

  16. Variable impact of Malaysia's national language planning on non-Malay speakers in Sarawak Impacto variável do planejamento linguístico nacional da Malásia sobre não falantes do Malaio em Sarawak

    Directory of Open Access Journals (Sweden)

    Su-Hie Ting

    2012-06-01

    Full Text Available The study examined the impact of the national language policy on the language use of three main ethnic groups in the Malaysian state of Sarawak. The data analyzed was based on a sociolinguistic survey on language use in six domains that involved 937 Malay, Chinese and Iban adolescents from three major towns in Sarawak. The results showed that the use of Bahasa Malaysia exceeded English usage for all three ethnic groups, showing the success of compulsory education in the national language. However, the language planning has greater impact on the Iban than on the Chinese who are shifting away from the ethnic languages of the Chinese sub-groups to Mandarin Chinese. The availability of an alternative standard language with international standing which also functions as a symbol of cultural solidarity compromises the impact of the national language policy.Este estudo examinou o impacto da política de ensino da língua nacional de três principais grupos étnicos no estado malaio de Sarawak. Os dados analisados basearam-se em uma pesquisa sociolinguística sobre o uso da língua em seis domínios e envolveu 937 adolescentes malaios, chineses e Iban de três grandes cidades de Sarawak. Os resultados mostraram que o uso da língua Bahasa da Malásia superou o uso do inglês para todos os três grupos étnicos, comprovando o sucesso da escolaridade obrigatória em língua nacional. No entanto, o planejamento do estudo da língua tem maior impacto sobre o Iban do que sobre os chineses. Estes estão se afastando das línguas étnicas dos subgrupos chineses para o chinês Mandarim. A disponibilidade de uma língua alternativa padrão, com prestígio internacional, que também funciona como um símbolo de solidariedade cultural, compromete o impacto da política de ensino da língua nacional.

  17. Sobre as relações entre o sexual e o mal-estar na civilização: uma discussão acerca das perspectivas freudianas the relationship between sexuality and the discontent in civilization: a debate regarding on Freudian perspectives

    Directory of Open Access Journals (Sweden)

    Clara Virginia de Q. Pinheiro

    2006-01-01

    Full Text Available O objetivo do presente artigo é examinar as formulações freudianas acerca das relações entre o sujeito às voltas com encontrar possibilidades de satisfação libidinal e o avanço da civilização. Consideramos que podemos estabelecer diferenças entre duas concepções freudianas: 1 uma oposição entre sexualidade e coletividade; 2 a civilização como vínculo libidinal. A primeira refere-se ao texto "Moral sexual civilizada e doença nervosa moderna" (1908 e a segunda, ao texto de 1930, "Mal-estar na civilização". A propósito da noção de civilização, estabelecemos uma articulação entre Freud e Norbert Elias, na medida em que partimos da idéia de que o conceito de civilização em Freud remete à experiência propriamente moderna de formação de laço social. Trata-se, com efeito, de uma forma de sociabilidade baseada na auto-regulação.This article’s aim is to analyze the Freudian formulations regarding the relationship between the subject, occupied with finding possibilities of libidinous satisfaction, and the advance of civilization. We consider that a difference can be established between two Freudian conceptions 1 an opposition between sexuality and collectivity; 2 civilization as a libidinous bond. The first one is found in the text "Civilized sexual morality and modern nervousness" (1908, and the second in the text of 1930, "Civilization and its discontents". Regarding the conception of civilization, we relate ideas of Freud and Norbert Elias, since we consider that the concept of civilization in Freud refers to the modern experience of social bond. Therefore, it is a form of sociability based on self-regulation.

  18. Ação de mosquiteiros impregnados com deltametrina sobre a morbidade da malária em uma área da Amazônia Brasileira The effect of bed nets impregnated with deltamethrin on malaria morbidity in an endemic area of the Brazilian Amazonian Region

    Directory of Open Access Journals (Sweden)

    João Barberino Santos

    1998-02-01

    Full Text Available Em 1992 foi feita uma investigação sobre o efeito protetor do uso de mosquiteiros impregnados com deltametrina, em uma população do município de Costa Marques, Rondônia, sujeita à transmissão malárica. Os mosquiteiros impregnados se comportaram de modo semelhante aos não impregnados, sem modificar os índices de infecção na época de baixa transmissão. A análise multivariada, por idade e títulos de anticorpos, mostrou uma proteção significante para o grupo com mosquiteiros impregnados contra o risco de infecção, apenas na estação de alta transmissão, quando os mosquiteiros foram usados mais regularmente. Não houve diferença no efeito de ambos os tipos de mosquiteiros na prevenção de elevadas parasitemias. Ao fim do estudo, ocorreu diminuição da prevalência de esplenomegalia em ambos os grupos, porém houve uma aparente recuperação da taxa normal de hematócrito em menores de 15 anos de idade em uso de mosquiteiros impregnados.In 1992 an investigation regarding the value of insecticide impregnated mosquito nets was conducted in the municipality of Costa Marques, Rondonia. Impregnated mosquito nets gave similar protection to those not impregnated, without modifying the incidence of infection during the season of low transmission. The multivariate analysis for age and antibody titre showed a significant protection of impregnated nets against the risk of infection only in the season of high transmission, when bed nets were used more correctly. There was no difference in the effect of both kinds of bed nets in the prevention of high parasitaemia. At the end of the study, there was a reduction of the prevalence of splenomegaly in both groups but hematocrit values rose to normal in the below 15 year olds using impregnated nets.

  19. Compatibilidade de Dicyma pulvinata com defensivos agrícolas e eficiência do biocontrole do mal-das-folhas da seringueira em campo Compatibility of Dicyma pulvinata with pesticides and biocontrol efficiency of South American leaf blight of rubber tree under field conditions

    Directory of Open Access Journals (Sweden)

    Débora Ferreira Melo

    2008-02-01

    Full Text Available O objetivo deste trabalho foi avaliar quatro isolados do fungo antagonista Dicyma pulvinata quanto à compatibilidade com defensivos agrícolas e adjuvantes, e a eficiência desses isolados no controle do mal-das-folhas (Microcyclus ulei da seringueira (Hevea sp. em campo. A compatibilidade dos isolados com defensivos e adjuvantes foi avaliada com base no crescimento micelial e na esporulação do fungo, em testes conduzidos in vitro. Para avaliação da eficiência do antagonista contra M. ulei, em campo, os quatros isolados do antagonista foram comparados ao controle exercido pelo tratamento com os fungicidas propiconazol + mancozeb. Os ensaios conduzidos em laboratório indicaram a incompatibilidade de D. pulvinata com os fungicidas benomyl, carbendazim, mancozeb, propiconazol e, ainda, com o inseticida acaricida endosulfan. Dois dos adjuvantes testados (Tween 20 e Tween 80 não afetaram o desenvolvimento do fungo. Foi comprovada a ação do antagonista D. pulvinata sobre M. ulei, em campo, com destaque para os isolados CEN 62 e CEN 93, que apresentaram eficiência de controle semelhante ao tratamento fungicida padrão.The objective of this work was to evaluate four isolates of the antagonist fungus Dicyma pulvinata in terms of its compatibility with chemical pesticides and adjuvants products, and the efficiency of these isolates as biocontrol agent against South American leaf blight (Microcyclus ulei of rubber tree (Hevea sp. under field conditions. Isolates compatibility with chemical pesticides and adjuvants was evaluated on mycelial growth and fungus sporulation in vitro. To assess the efficiency of the antagonist against M. ulei under field conditions, the four isolates were compared to the control by the fungicide mixture propiconazol + mancozeb. The assays showed incompatibility of the antagonistic fungus with the fungicides benomyl, carbendazim, mancozeb, propiconazol, besides the insecticide-acaricide endosulfan. Two of the adjuvants

  20. Populations of larvae of Anopheles spp. in natural breeding sites in Western Venezuela, an area of refractory malaria População de larvas de Anopheles spp. em criadouros naturais em área de malária refratária da Venezuela Ocidental

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    Eliana Rojas

    1992-10-01

    Full Text Available Studies have been un dertaken into on the diversity and relative abundance of larvae of Anopheles (Nyssorhynchus spp. in 22 permanent or temporary pools in an area of 70 km² in the eastern piedmont of the Venezuela Andes, between the mountains and the plains, an area in which malaria is refractory and A. nuñeztovari is present. Twelve species were identified, the most frequent, abundant and sympatric being A. triannulatus, A. albitarsis, A. nuñeztovari, A. oswaldoi and A. strodei. The samples from the permanent pools showed greater diversity of species and greater numbers of larvae than the samples from the temporary pools. The existence of the same larval associations in pools of other localities in the eastern piedmont of the Venezuelan Andes suggests the possibility of the making an ecological map of the breeding sites of A. nuñeztovari and for these anophelines in a region extending for 430 km.Tem-se estudado a diversidade e a riqueza de larvas de Anopheles (Nyssorhynchus spp. em 22 postos permanentes e temporais em área de 70 km² ao pé da Cordilheira Andina Oriental da Venezuela, em região de malária refratária. Foram identificadas 12 espécies, sendo as mais freqüentes, abundantes e simpátricas as A. triannulatus, A. albitarsis, A. nuñeztovari, A. oswaldoi y A. strodei. Foi maior o número de espécies e de larvas por amostra nos postos permanentes do que nos temporais. A existência das mesmas associações larvais, em postos de outras localidades, ao pé da Cordilheira Andina Oriental da Venezuela, baseia-se no ponto de vista de que é possível fazer-se um mapa ecológico dos criadouros dessas espécies de Anopheles em região de 430 km de extensão.

  1. Malaria transmission model for different levels of acquired immunity and temperature-dependent parameters (vector Modelo de transmissão de malária em diferentes níveis de imunidade e de parâmetros temperatura-dependentes (vetor

    Directory of Open Access Journals (Sweden)

    Hyun M Yang

    2000-06-01

    Full Text Available OBJECTIVE: Describe the overall transmission of malaria through a compartmental model, considering the human host and mosquito vector. METHODS: A mathematical model was developed based on the following parameters: human host immunity, assuming the existence of acquired immunity and immunological memory, which boosts the protective response upon reinfection; mosquito vector, taking into account that the average period of development from egg to adult mosquito and the extrinsic incubation period of parasites (transformation of infected but non-infectious mosquitoes into infectious mosquitoes are dependent on the ambient temperature. RESULTS: The steady state equilibrium values obtained with the model allowed the calculation of the basic reproduction ratio in terms of the model's parameters. CONCLUSIONS: The model allowed the calculation of the basic reproduction ratio, one of the most important epidemiological variables.OBJETIVO: Propõe-se um modelo compartimental para descrever a transmissão de malária, levando em consideração duas populações envolvidas: o hospedeiro humano e o vetor mosquito. MÉTODOS: Desenvolveu-se um modelo matemático baseado nas seguintes características: em relação ao hospedeiro humano, assumiu-se a existência de imunidade adquirida e de memória imunológica que, em uma reinfecção, leva ao reforço da resposta imune; em relação ao vetor mosquito, levou-se em consideração que o período médio de desenvolvimento desde ovo até mosquito adulto e o período de incubação extrínseco de parasitas (transformação de mosquitos infectados mas não-infecciosos em mosquitos infecciosos são dependentes de temperatura ambiente. RESULTADOS: Foram obtidos os valores do equilíbrio no estado estacionário do modelo proposto. Da análise da estabilidade dos pontos de equilíbrio, foi determinada a razão de reprodutibilidade basal. CONCLUSÕES: Foi obtida uma variável epidemiológica importante, a razão de

  2. Založení malého podniku

    OpenAIRE

    Vacík, Jakub

    2012-01-01

    The bachelor graduation theses deal with realisation of a specific business plan. Based on a prior comparison of a joint-stock company and a limited liability company, the limited liability company was chosen. In the bachelor graduation theses, a company named VASTE Trans Ltd was established. Its main activity consists in providing transport services inside as well as outside the European Union. The company was established by Jakub Vacík and Petra Steiningerová. The bachelor graduation th...

  3. Analisis Yuridis Tentang Tanggung Jawab Notaris Kaitannya Dengan Mal Administrasi

    OpenAIRE

    Nadapdap, Masda

    2010-01-01

    A notary in charge of organizing his client always belongs to a group of persons holding a trustworthy position because he is a person who approves or gives an authentic power for a notarial document (act) truly made before him based on the standard notary’s professional ethics and the existing legal stipulation. As a public officer with an authority to make and issue a notarial document (act), a notary is required to work independently, honestly, not taking sides, full of responsibility, and...

  4. Návrh malého podkopu

    OpenAIRE

    John, Václav

    2015-01-01

    Hlavní náplní bakalářské práce je návrh podkopu za malotraktor. První část práce se zabývá principem podkopu. V druhé části byly uvažovány různá řešení jednotlivých komponent. Ve třetí části jsou uvedené základní výpočty konstrukce a závěrem jsou znázorněné modely komponent vlastní konstrukční varianty.

  5. Obchodní strategie malého podniku

    OpenAIRE

    Hourová, Tereza

    2013-01-01

    The thesis deals with the business strategy of a middle-sized entrepreneur in the food manufacturing industry. The theoretical part explains basic terms, introduces methods of a strategic analysis and describes basic approaches to formulating the strategy. The practical part contains the strategic analysis of a specific entrepreneur created using the PEST analysis, the Porter five forces analysis, and the Value Chain Analysis. The practical part also includes suggested business strategies det...

  6. Geografie malých měst

    Czech Academy of Sciences Publication Activity Database

    Vaishar, Antonín; Kallabová, Eva

    Praha : Univerzita karlova v Praze, Přírodovědecká fakulta, geografická sekce, 2006 - (Treml, V.; Chromý, P.), s. 22-23 ISBN 80-86561-96-8. [150 let Geografie na UK v Praze. Praha (CZ), 10.11.2006-11.11.2006] R&D Projects: GA AV ČR IAA3086301 Institutional research plan: CEZ:AV0Z30860518 Keywords : small towns * percpetion * urban liveability * regional geography Subject RIV: DE - Earth Magnetism, Geodesy, Geography

  7. L’ergot du seigle et le mal des Ardents*

    OpenAIRE

    Aillaud, Georges J.

    2014-01-01

    Choisir de parler de l’ergot du seigle comme plante médicinale peut paraître a priori surprenant. Et pourtant, cette formation d’un centimètre de longueur, dure, noire, fait bien partie du règne végétal. C’est la forme de résistance d’un champignon. De plus, l’ergot du seigle a bel et bien été inscrit à la pharmacopée et il est aujourd’hui à l’origine de très nombreux médicaments importants. L’histoire de l’ergot du seigle est vraiment exemplaire : à l’origine d’une terrible maladie d’allure ...

  8. Ulutshit zhizn v malõhh gorodahh mozhno / Georgi Bõstrov

    Index Scriptorium Estoniae

    Bõstrov, Georgi, 1944-

    2007-01-01

    Konstitutsioonierakonna nimekirjas Riigikokku kandideeriv Maardu linnapea teeb ettepaneku, kuidas suurendada väikeste omavalitsuste tulu. Partei ettepanekutest maksusüsteemi muutmiseks. Erakond peab oluliseks, et pension ei oleks väiksem kui 45% palgast, tulumaksuvaba miinimum peab vastama elatusmiinimumi suurusele

  9. MAL decreases the internalization of the aquaporin-2 water channel.

    NARCIS (Netherlands)

    Kamsteeg, E.J.; Duffield, A.S.; Konings, I.B.M.; Spencer, J.; Pagel, P.; Deen, P.M.T.; Caplan, M.J.

    2007-01-01

    Body water homeostasis depends critically on the hormonally regulated trafficking of aquaporin-2 (AQP2) water channels in renal collecting duct epithelial cells. Several types of posttranslational modifications are clearly involved in controlling the distribution of AQP2 between intracellular vesicl

  10. Audit malé společnosti

    OpenAIRE

    FRAŇKOVÁ, Lenka

    2009-01-01

    This student work contains description and application of complete audit works. This student work is divided into two parts, the theoretical and the practical one. In the theoretical one I was interested in basic principles of audit, such as definition, functions, legal requirements and detailed actions during the whole process of audit. All mentioned procedures are applied in the practical part of my work. The true and fair view, especially whether financial statements present fairly in all ...

  11. O mal-estar docente em gestores escolares

    Directory of Open Access Journals (Sweden)

    Cátia Cristina Xavier Mazon

    2013-08-01

    Full Text Available This research aimed to identify and analyze the impact of stressful events associated with the school administrators in teacher malaise. 29 managers participated in his capacity as directors or deputy directors of the municipal system, the interior of São Paulo, with responses to the Inventory IMPIL (Evaluación Psicológica Del Estrés por InestabilidadLaboral - FIGUEROA; SCHUFER, 2006. The results indicate the presence of stressors in all areas assessed at different rates. The highest ranking stressors were concerns with health, emotional Diseases and economic concerns. The degree of discomfort tends to increase with age, but since the entry into this function. The extensive powers of management, indicate the occurrence of different degrees of impact between the groups, demonstrating that subjectivity needs to be considered for proposing improvements in working conditions and health organizations. Social changes, the demands of educational reforms and lack of recognition of the profession were associated with teacher malaise.

  12. Projekt malé rodinné farmy

    OpenAIRE

    Pražák, Tomáš

    2014-01-01

    Diploma thesis "The establishment of small family farm" deals with the general insight into the World, European and Czech grant policies. Insight into eco-farm business in agriculture and agro-tourism. The paper gives an overview of both the economic point of view and from a practical standpoint what all is needed for establishing the farm. Main part of the thesis concerns about investment plan for the project of founding family eco-farm, business and services description, technical&techn...

  13. Kak zavorozhit voronezhtsev / Jekaterina Dubina ; interv. Natalija Malõsheva

    Index Scriptorium Estoniae

    Dubina, Jekaterina

    2006-01-01

    Tallinna Euroülikooli moeeriala üliõpilase Jekaterina Dubinaga tema erialasest tegevusest ja osalemisest Voronezhi noorte disainerite festivalil "Kubermangu stiil". Katja kollektsioon "Mägede kevad" sai seal esikoha

  14. Tvorba marketingové strategie malé firmy

    OpenAIRE

    Šťastná, Jana

    2011-01-01

    This bachelor thesis deals with marketing strategy of mid-sized company called TRIPOR Ltd., the business deals with buying and selling porcelain and glass .The business is located in Klášterec nad Ohří. The aim of this work is to analyze the current marketing strategy of the company, its evaluation, suggestion and marketing strategy of the company. The work is divided into two chapters. The first chapter deals with the theoretical part, which describes the particular theory of marketing. The ...

  15. Marketingová komunikace malé firmy na internetu

    OpenAIRE

    Knápková, Kamila

    2014-01-01

    In the thesis I focus on selected instruments of internet marketing which are suitable for small size companies. The terms internet advertising and internet sales promotion instruments are explained in the first chapter. Sufficient part of the thesis is dedicated to the rules of webpage creation and the means of their optimization for search engines (SEO) as well as to the options of their attendance measuring (Google Analytics).The second chapter is focused on the concept of content marketin...

  16. Videogame: é do bem ou do mal? Como orientar pais

    Directory of Open Access Journals (Sweden)

    Luciana Alves

    2011-06-01

    Full Text Available Desde a década de 70 milhares de crianças, adolescentes e adultos praticam jogos de computador ou videogame. O objetivo deste artigo foi identificar os efeitos deste artefato tecnológico para a cognição, sua aplicabilidade e sua influência sobre o comportamento e a saúde do jogador e, desta forma, delinear orientações para pais e profissionais de saúde que lidam com crianças e adolescentes. Na primeira parte do artigo são apresentados alguns efeitos negativos e positivos dos jogos; na segunda é proposto um conjunto de orientações que podem tornar a brincadeira mais segura; e na última parte, as considerações finais. Concluiu-se que o videogame é uma ferramenta capaz de aperfeiçoar as habilidades cognitivas e perceptivas, sendo os jogos educacionais apontados como uma experiência benéfica aos seus usuários, e que as repercussões negativas se referem, principalmente, ao efeito daqueles com conteúdo de violência.

  17. Malé město a ohniska architektury

    Czech Academy of Sciences Publication Activity Database

    Kratochvíl, Petr

    Praha : Architectura, Galerie Jaroslava Fragnera, 2014 - (Merta, D.), s. 8-9 ISBN 978-80-905782-4-1 Institutional support: RVO:68378033 Keywords : modern architecture * topography * theory of architecture Subject RIV: AL - Art, Architecture, Cultural Heritage

  18. Malý třesk v CERNu

    Czech Academy of Sciences Publication Activity Database

    Křížek, Filip

    2012-01-01

    Roč. 57, č. 2 (2012), s. 102-121. ISSN 0032-2423 Institutional support: RVO:61389005 Keywords : Cern * LHC * ALICE * heavy ion collisions * quark gluon plasma Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders

  19. De la Nación como el mal

    OpenAIRE

    Montaño-Montero, Luisa

    2013-01-01

    ¿Podemos afirmar que el origen del sentimiento nacionalista vasco es espontáneo? La autoconciencia de pertenencia a un determinado pueblo ha sido, en este caso en concreto, producto de una serie de reinterpretaciones históricas, mitológicas y lingüísticas. Surge entonces la duda acerca de la bondad o la maldad de tales argumentos, es decir, se duda de la imparcialidad de tales ideas. Éste será el tema que trataremos de solventar, a saber: ¿es la ideología nacionalista buena o mala? Veremos...

  20. Mitochondria and the economy of stress (mal)adaptation

    NARCIS (Netherlands)

    Morava, E.; Kozicz, T.L.

    2013-01-01

    Stress-associated diseases, like depression have a life time prevalence of up to 20%, and approximately 18.4 million people in Europe suffer from depression. Despite decades of research, we still do not understand completely this complex brain disease. Increasing body of correlative evidence implica

  1. Rudolphinische Zentralbauten: mal connues, méconnues et inconnues

    Czech Academy of Sciences Publication Activity Database

    Muchka, Ivan

    -, č. 8 (2008), s. 7-17. ISSN 1213-5372 Institutional research plan: CEZ:AV0Z80330511 Keywords : sacral architecture * Renaissance * garden follies * Rudolf II * Prague Castle Subject RIV: AL - Art, Architecture, Cultural Heritage

  2. "Un monstruo absoluto": Armando Normand y la sublimidad del mal

    Directory of Open Access Journals (Sweden)

    Carlos Guillermo Páramo Bonilla

    2010-05-01

    Full Text Available Entre todos los personajes acusados de crímenes atroces en las caucheras del Putumayo (ca. 1912, ninguno ha producido tanto horror y fascinación como Armando Normand. En este artículo seguimos la pista de esta vida infame, incorporando el camino material previamente no reseñado y examinando cómo y por qué ingresó a la mitología de la frontera, en cuanto arquetipo del terror. Por lo mismo se observa de cerca su relación con las figuras de Roger Casement y el emblemático Kurtz de "El corazón de las tinieblas" de Joseph Conrad. Asimismo se aprovecha la circunstancia para discutir con algunos planteamientos de Michael Taussig, Gananath Obeyesekere y Michel Foucault.

  3. "un monstruo absoluto": armando normand y la sublimidad del mal

    OpenAIRE

    Carlos Guillermo Páramo Bonilla

    2010-01-01

    Entre todos los personajes acusados de crímenes atroces en las caucheras del Putumayo (ca. 1912), ninguno ha producido tanto horror y fascinación como Armando Normand. En este artículo seguimos la pista de esta vida infame, incorporando el camino material previamente no reseñado y examinando cómo y por qué ingresó a la mitología de la frontera, en cuanto arquetipo del terror. Por lo mismo se observa de cerca su relación con las figuras de Roger Casement y el emblemático Kurtz de "El corazón d...

  4. "Mal ist es ein Scheißleben und mal ganz cool": Psychotherapie und Beratung mit Jugendlichen

    OpenAIRE

    Bräutigam, Barbara

    2011-01-01

    "Dieser Beitrag versucht allgemeine und therapieschulenübergreifende Prinzipien herauszuarbeiten, die für die therapeutische Arbeit mit Jugendlichen von Bedeutung sind. Dabei konzentriert sich der Beitrag in erster Linie auf notwendige Kenntnisse über die entwicklungspsychologischen Spezifika der Jugendphase und die Anforderungen an die Therapeutenpersönlichkeit und geht nicht auf spezifische Interventionen bei jugendspezifischen Störungsbildern ein. Ein Kern des Beitrags ist die Darstellung ...

  5. Epidemiological and ecological aspects related to malaria in the area of influence of the lake at Porto Primavera dam, in western São Paulo State, Brazil Aspectos epidemiológicos e ecológicos relacionados à malária na área de influência do lago da Represa de Porto Primavera, região oeste do Estado de São Paulo, Brasil

    Directory of Open Access Journals (Sweden)

    Almério de C. Gomes

    2008-10-01

    this paper.Foi realizada pesquisa na área de influência do lago da Usina Hidrelétrica de Porto Primavera, região oeste do Estado de São Paulo, para estudar aspectos ecológicos e epidemiológicos da malária na localidade e acompanhar o perfil das populações de anofelinos frente às mudanças decorrentes do impacto ambiental pela formação do lago. Mosquitos capturados foram analisados pelo Índice de Abundância de Espécies Padronizado (IAEP, antes e durante o enchimento do reservatório (cotas 253 e 257 m. A população humana local foi estudada por meio de teste parasitológico (gota espessa e esfregaço sangüíneo, testes moleculares (PCR e testes sorológicos. A sorologia consistiu na reação de ELISA com peptídeos sintéticos correspondentes à porção repetitiva da proteína circumsporozoíta (CSP de Plasmodium vivax clássico, e suas variantes VK247 e "vivax-like", P. malariae e P. falciparum; e reação de Imunofluorescência Indireta (RIFI com formas assexuadas de P. vivax, P. malariae e P. falciparum. Os resultados do estudo entomológico indicaram que, embora a população de Anopheles darlingi tenha aumentando após o enchimento, permaneceu em baixa densidade. Não foi detectada malária nem a presença de parasitos ou de DNA parasitário nos habitantes estudados. No entanto, foi observada baixa freqüência de anticorpos contra formas assexuadas e significativa prevalência de anticorpos contra esporozoítos de P. vivax e suas variantes, P. falciparum e P. malariae, que poderiam decorrer de contatos prévios, recentes ou não, com plasmódios humanos ou símios (o ciclo silvestre foi evidenciado em estudo paralelo realizado na mesma área. Por outro lado, estes resultados sugerem que, como em outros lugares onde existem vetores potenciais da malária, as condições epidemiológicas poderiam potencialmente permitir a transmissão da malária na área de influência do lago de Porto Primavera, se indivíduos infectados fossem introduzidos em n

  6. "O que vêm da terra não faz mal": relatos de problemas relacionados ao uso de plantas medicinais por raizeiros de Diadema/SP "Natural and therefore free of risks": adverse effects, poisonings and other problems related to medicinal herbs by "raizeiros" in Diadema/SP

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    Juliana Lanini

    2009-03-01

    Full Text Available A crença de que medicamentos à base de plantas são isentos de riscos à saúde faz parte da bagagem cultural da população afeita ao seu uso: "o que vêm da terra não faz mal". No entanto, o potencial tóxico, as características específicas do usuário, a possibilidade de contaminação e a falta de regulamentação constituem fatores de risco para a ocorrência de reações adversas, intoxicações e outras complicações decorrentes de seu uso. Foram realizadas entrevistas semi-estruturadas junto a 20 raizeiros (vendedores de ervas "in natura" na cidade de Diadema/SP. Foram relatados 40 casos de problemas relacionados ao uso de 22 espécies de plantas medicinais. As espécies mais citadas foram Luffa operculata - buchinha (7 casos, Senna alexandrina - sene (4 casos e Paullinia cupana - guaraná (3 casos. Dentre os sinais e sintomas relatados, os mais freqüentes foram relacionados ao sistema nervoso central, problemas gastrointestinais e cardiovasculares. Os entrevistados também relataram um caso de aborto relacionado ao uso de S. alexandrina e três casos de óbito após a ingestão do chá do fruto de L. operculata. O caráter "natural" das plantas medicinais não é sinônimo de ausência de riscos para a população usuária. É necessária a implantação de políticas de fitofarmacovigilância eficientes, a fim de tornar o consumo mais racional e, deste modo, minimizar os riscos à população usuária.Traditionally, medicinal herbs have been considered gentle and harmless because of their natural origin: "natural and therefore free of risks". However, toxic potential, various consumer-related factors (such as age, disease factors, pregnancy, etc, contamination, and lack of regulation concerning quality control are some of the risk factors deemed to be associated with herbal adverse reactions, poisonings and other complications. Over a 7-month period, semi-structured interviews were carried out with 20 "raizeiros" (traditional

  7. Colonização micorrízica arbuscular e tolerância ao mal-do-Panamá em mudas de banana-maçã Colonisation of arbuscular mycorrhiza and tolerance to Panama disease in seedlings of the maçã banana

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    Deusiane Batista Sampaio

    2012-09-01

    Full Text Available O objetivo desse trabalho foi avaliar o efeito da colonização micorrízica arbuscular na tolerância da bananeira, cv. Maçã, ao mal-do-Panamá, sob diferentes fontes de nutrientes. Utilizou-se um delineamento inteiramente casualizado com fatorial 2 x 4 [2 densidades de esporos de FMA nativos (D1 - 3.500 esporos kg-1 solo e D2 - 7.000 esporos kg-1 solo e 4 diferentes concentrações de fontes de nutrientes - três de solução nutritiva (SN 40%, SN 70% e SN 100% e uma de biofertilizante 100% (B4] com três repetições. Após o plantio inoculou-se Fusarium oxysporum f.sp. cubense e posteriormente avaliou-se matéria seca da parte aérea (MSPA, o teor de fósforo foliar (P, a colonização micorrízica, o pH do solo e o índice de severidade da doença (ID. As diferentes fontes de nutrientes influenciaram a matéria seca da parte aérea, o teor de fósforo, a colonização micorrízica e o índice de severidade da doença, porém não influenciaram o pH da solução do solo. O biofertilizante não atendeu à demanda nutricional das plantas, as quais se mostraram pouco desenvolvidas. Porém proporcionou intensa colonização micorrízica e menor índice de severidade da fusariose, o qual aumentou com a adubação mineral.The aim of this study was to evaluate the effect of the colonization of arbuscular mycorrhiza on the tolerance to Panama disease of the banana plant cv. maçã under different sources of nutrients. A completely randomized design was employed, having a 2 x 4 factorial [2 densities of native FMA spores (D1 - 3,500 spores kg-1 soil and D2 - 7000 spores kg-1 soil and four different concentrations of nutrient sources - three of a nutrient solution (SN 40%, SN 70% and SN 100% and a 100% solution of bio-fertiliser (B4], with three replications. After planting, the seedlings were inoculated with Fusarium oxysporum f.sp. cubense, and later the shoot dry matter, leaf phosphorus content, mycorrhizal colonization, soil pH and disease

  8. Clinical Observation of 50 Cases of White Lesions of the Vulva Treated with Chinese Medicine Fumigation and Local Medicine Microwave Ther-mal Irradiation%中药熏洗结合局部上药微波导热治疗外阴白色病变50例临床观察

    Institute of Scientific and Technical Information of China (English)

    潘怡

    2016-01-01

    目的 观察中药熏洗结合局部上药微波导热方法治疗外阴白色病变的临床疗效.方法 将门诊100例外阴白色病变患者按数字随机表法分为治疗组和对照组,每组50例.治疗组采用中药"去白止痒方"加减熏洗外阴,其后病灶局部涂擦鱼肝油滴剂、维生素E胶囊及氟轻松软膏,再进行微波导热照射治疗;对照组采用局部氟轻松软膏上药加微波导热治疗.两组治疗均1次/d,每10次为1个疗程,完成3个疗程后进行疗效评价.结果 治疗后治疗组总有效率96.0%,对照组总有效率72.0%,两组疗效比较,差异有统计学意义(P<0.01).结论 中药熏洗结合局部上药微波导热治疗外阴白色病变疗效确切、方法简便,值得在基层推广使用.%Objective To observe the clinical efficacy on white lesions of the vulva treated with Chinese medicine fumigation and local medicine microwave thermal irradiation. Methods One hundred out-patients of white lesions of the vulva were randomized into a treatment group and a control group,50 cases in each one. In the treatment group,the fumigation was applied locally with qubai zhiyang fang,followed by local application of oleum morrhuae drops,vitamin E capsule and fluocinonide ointment,as well as microwave ther-mal irradiation. In the control group,the local application of fluocinonide ointment and microwave thermal ir-radiation were applied. The treatment was given once a day,10 treatments made one session. The evaluation was done after 3 sessions. Results The total effective rate was 96. 0% in the treatment group and was 72. 0% in the control group after treatment,indicating the significant difference in comparison(P < 0. 01).Conclusion The combined therapy of Chinese medicine fumigation and local medicine microwave thermal irradiation achieves the definite efficacy on white lesions of the vulva. This therapy is simple in application and deserves to be promoted.

  9. Relação entre hábitos bucais, alterações oronasofaringianas e mal-oclusões em pré-escolares de Vitória, Espírito Santo, Brasil The relationship between oral habits, oronasopharyngeal alterations, and malocclusion in preschool children in Vitória, Espírito Santo, Brazil

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    Adauto Emmerich

    2004-06-01

    Full Text Available O objetivo deste estudo foi estimar a prevalência das mal-oclusões e variáveis a elas associadas, como hábitos deletérios (HD e as alterações oronasofaringianas (AO, respiração bucal, deglutição atípica e fonação atípica, em crianças com idade de três anos, no Município de Vitória, Espírito Santo, Brasil. A amostra constituiu-se de 291 crianças de ambos os sexos, matriculadas nos Centros de Educação Infantil, selecionadas por meio de amostragem probabilística por conglomerados. A análise de regressão logística indicou maior risco relativo (RR de crianças com sobressaliência alterada, mordida aberta e mordida cruzada, em apresentar: respiração bucal (RR = 1,89; IC: 1,56-2,03, (RR = 2,46; IC: 2,00-3,02, (RR = 1,45; IC: 1,23-1,72; deglutição atípica (RR = 2,57; IC: 1,87-3,52, (RR = 3,49; IC: 2,53-4,81, (RR = 1,86; IC: 1,46-2,39 e fonação atípica (RR = 2,25; IC: 1,66-3,05, (RR = 3,18; IC: 2,38-4,25, (RR = 1,71; IC: 1,32-2,22, respectivamente. Foi mostrado haver associação entre sucção de dedo e de chupeta com sobressaliência alterada (p The objective of this study was to estimate the prevalence of malocclusion and associated variables such as deleterious habits (DH and oronasopharyngeal alterations (OA, mouth breathing, atypical phonation, and atypical swallowing in three-year-old children in Vitória, Espírito Santo State, Brazil. The sample included 291 children of both sexes enrolled in a Children's Educational Center and selected through probability sampling by conglomerates. Logistic regression indicated a high relative risk (RR in children with altered overjet, open bite, and cross-bite to present mouth breathing (RR = 1.89; CI: 1.56-2.03, (RR = 2.46; CI: 2.00-3.02, (RR = 1.45; CI: 1.23-1.72; atypical swallowing (RR = 2.57; CI: 1.87-3.52, (RR = 3.49; CI: 2.53-4.81, (RR = 1.86; CI: 1.46-2.39; and atypical phonation (RR = 2.25; CI: 1.66-3.05, (RR = 3.18; CI: 2.38-4.25, (RR = 1.71; CI: 1

  10. 钽棒植入联合自体骨髓间充质干细胞移植治疗早期股骨头缺血性坏死%Early Clinical Results of Implantation of Tantalum Rod Combined Transplantation of Autologous Bone Marrow Mesenchy-mal Stem Cells for Early Stage of Avascular Necrosis of Femoral Head

    Institute of Scientific and Technical Information of China (English)

    梁红锁; 黄克; 李林; 张波; 韦程寿

    2014-01-01

    Objective:To study the effects of implantation of tantalum rod and transplantation of autologous bone mar-row mesenchymal stem cells for early stage of avascular necrosis of femoral head .Methods:27 patients with avascular necrosis of femoral head in the early stage were treated with implantation of tantalum rod and transplantation of autolo-gous bone marrow mesenchymal stem cells .Results:The average period of follow-up was thirteen months (7 ~ 24 months) .Pain of all patients disappeared .The movement range of the hip joint was normal or approximate to normal . Except two cases evolved to stage of ARCOⅢ ,X-ray showed that cystic degeneration disappeared .The Harris score was 54 .2 ± 7 .1 before operation and it increased significantly to 83 .9 ± 8 .6 after operation .Conclusion:It has the ad-vantage to minimal damage of implantation of tantalum rod and transplantation of autologous bone marrow mesenchy-mal stem cells for early stage of avascular necrosis of femoral head .It is an effective way for the treatment of femoral head necrosis .The short-term efficacy is good .%目的:观察钽棒植入联合自体骨髓间充质干细胞移植治疗早期股骨头缺血性坏死的临床疗效。方法:对27例ARCOⅠ、Ⅱ期的ANFH患者采用股骨头髓芯减压后植入钽棒并联合自体骨髓间充质干细胞移植。结果:所有患者经过7~24个月(平均13个月)的随访,关节疼痛基本消失,活动范围接近或恢复正常,除2例患者进展为ARCOⅢ期外,其余股骨头均无塌陷,影像学检查结果示股骨头囊性变消失,Harris评分由术前的(54.2±7.1)分提高到术后(83.9±8.6)分。结论:钽棒植入联合自体骨髓间充质干细胞移植治疗早期股骨头缺血性坏死,具有创伤小、疗效确切等优点,近期临床疗效良好。

  11. VARIACIONES DEL CONTENIDO DE Mn DE DOS SUELOS SOMETIDOS A ESTERILIZACIÓN Y SU EFECTO SOBRE LA PUDRICION RADICAL DEL TRIGO O "MAL DE PIE" Variation on Mn content of sterilized soil and their effect on take-all disease of wheat

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    Ricardo Campillo

    2001-07-01

    Full Text Available Se evaluó bajo condiciones controladas de invernadero, el efecto de la variación del contenido de Mn de un suelo supresivo y un suelo conducivo, sobre la expresión de la pudrición radical del trigo (Triticum aestivum L. o "mal de pie", causada por el hongo ascomicete Gaeumannomyces graminis (Sacc. von Arx & Olivier var. tritici Walker (Ggt. Se utilizaron dos suelos de la IX Región previamente determinados como: A naturalmente supresivo (ultisol y B como conducivo (andisol a la pudrición radical del trigo. Se evaluaron ambos suelos sembrados con trigo cv. Dalcahue - INIA durante 40 días, en su condición natural y bajo esterilización con autoclave y microonda, para observar el efecto del contenido de Mn sobre la expresión de la enfermedad. Los valores de Mn del suelo se incrementaron producto de la esterilización, en suelos supresivos desde 98,2 a 293 mg kg-1, y en suelos conducivos de 2,5 a 295 mg kg-1. La MS de las plantas no se vió afectada por las variaciones experimentadas por el Mn en estos suelos. El proceso de infección radical de las plantas de trigo operó en forma totalmente independiente del contenido de Mn disponible del suelo, sea éste supresivo o conducivo; la infección radical llegó a niveles tan altos como un 89%. Lo anterior indica que la inhibición de la infección observada al transferir 1% de suelo supresivo a una base de suelo estéril, no se debe al mayor contenido de Mn del suelo esterilizado, sino a factores bióticos asociados a esos suelos.The variation on Mn content of a suppressive and a conducive soils on the expression of take-all wheat (Triticum aestivum L. disease, caused by the fungus Gaeumannomyces graminis (Sacc. von Arx & Olivier var. tritici Walker (Ggt, was evaluated under controlled greenhouse conditions. Two soils of the Ninth Region previously determined to be A naturally suppressive (ultisol and B as conducive (andisol to wheat take-all disease were used. Both soils were seeded with wheat

  12. Cisticercose humana diagnosticada em hospital geral, São Paulo, SP (Brasil Human cysticercosis in a general hospital in S.Paulo, Brazil

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    Aluízio de Barros Barreto Machado

    1988-06-01

    Full Text Available Foi realizado estudo retrospectivo de pacientes internados no Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo (Brasil, no período de 7 anos (1979 a 1985, tendo sido diagnosticados 260 casos de cisticercose, correspondendo a 0,2% do total estudado. Os dados obtidos mostraram uma distribuição aproximadamente igual quanto ao sexo e o acometimento maior na faixa etária de 20 a 50 anos (53,8%. A neurocisticercose foi a forma mais freqüente e seu elevado percentual (91,5% foi atribuído às características da população estudada. Apesar do recente desenvolvimento da tecnologia diagnostica e terapêutica específicas, o tempo de permanência hospitalar médio foi de 35 dias e a letalidade média de 14,6%, apontando para a necessidade de medidas profiláticas através de programas de saúde pública.In this retrospective study of 126,968 in-patients at the Hospital das Clínicas of S. Paulo Medical School, S. Paulo, from 1979 to 1985, cysticercosis was diagnosed in 260 (0.2% of them Epidemiological data obtained from these 260 patients showed a dose distribution with regard to sex, and the age group from 20 to 50 years old was the most affected (53.8%. Neurocysticercosis was the most frequent and the high rate (91.5% was understood to be due to the characteristics of specific the patients studied. Despite the recent development of the diagnostic and therapeutic technology, the average length of hospitalization was 35 days and the rate of lethality 14.6%, pointing to the need for preventive measures on the part of public health programs.

  13. Enfermedad celiaca materna no diagnosticada y riesgo de tener hijos con bajo peso al nacimiento Maternal non-diagnosed celiac disease and risk of low birth weight

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    G. Solís Sánchez

    2008-06-01

    Full Text Available Objetivo: conocer la prevalencia de enfermedad celiaca en madres de neonatos mayores y menores de 2.500 gramos de peso al nacimiento. Pacientes: sujetos: casos: madres de neonatos menores de 2.500 g al nacimiento. Controles: madres de neonatos mayores de 2.500 g al nacimiento. Un control por cada caso. Instrumentalización: encuesta clínico-epidemiológica y serología celiaca. Métodos: estudio caso-control. Ámbito: mujeres del Área Sanitaria V (Gijón del Principado de Asturias que den a luz en el Hospital de Cabueñes. Resultados: se analizaron 1.103 mujeres: 577 madres de niños menores de 2.500 g y 526 madres de niños mayores de 2.500 g. Se diagnosticaron 4 casos de celiaquía, 2 en cada grupo. De las 4 madres, 3 dieron a luz a niños a término (1 caso cada 235 madres, prevalencia 0,42% y 1 dio a luz a un niño prematuro (1 caso cada 389 madres, prevalencia 0,26%. Dos madres dieron a luz a niños de peso adecuado para su edad gestacional (1/419 madres, prevalencia 0,24% y 2 madres dieron a luz niños de bajo peso para su edad gestacional (1/132 madres, prevalencia 0,75%. La odds ratio para peso menor de 2.500 g al nacimiento fue 0,91 (IC 95% 0,12-6,49, para prematuridad 0,61 (IC 95% 0,06-5,89 y para bajo peso para su edad gestacional 3,19 (0,44-22,79. Conclusiones: la prevalencia de enfermedad celiaca en mujeres fértiles de Gijón es de un caso cada 275 madres (prevalencia 0,36%, sin que hayamos encontrado diferencias entre los dos grupos estudiados.Aims: in order to know the prevalence of celiac disease in mothers with newborns weighing less or more than 2,500 g at birth we carried out a case-control study. Patients: mothers of newborns in Cabueñes Hospital. Case group: Mothers with babies weighing less than 2,500 g at birth. Controls: Mothers with babies weighing more than 2,500 g at birth. One control for each case. Methods: epidemiological and clinical interviews, and celiac disease serology. Results: we studied 1103 women: 577 cases and 526 controls. We diagnosed 4 celiac disease cases, 2 in the case group and 2 in the control group. These 4 mothers had 3 term newborns (1 case in each 235 mothers; prevalence 0.42% and 1 preterm newborn (1 case in each 389 mothers; prevalence 0.26%. Two cases had babies with adequate birth weight for their gestational age (1 case in each 419 mothers; prevalence 0.24% and two cases had babies with low birth weight for their gestational age (1 in each 132 mothers; prevalence 0.75%. The odds ratio for low birth weight was 0.91 (95% CI: 0.12-6.49, the odds ratio for preterm birth was 0.61 (95% CI: 0.06-5.89, ad the odds ratio for low birth weight for gestational age was 3.19 (95% CI: 0.44-22.79. Conclusions: the prevalence of celiac disease in fertile women in our geographic area was 0.36% (1 case in each 275 mothers, and no differences were found between study groups.

  14. Identificación en el gabinete dental de la diabetes y prediabetes no diagnosticada mediante parámetros periodontales

    OpenAIRE

    Alcocer Sánchez, María Luisa

    2012-01-01

    El presente estudio ha sido realizado en una clínica dental privada en Valladolid por la Doctora Mª Luisa Alcocer Sánchez y tutorizado por el Doctor Antonio Bascones Martínez. Se ha trabajado con la colaboración del Laboratorio de Análisis Clínicos Canga - Arqueros. Se ha llevado a cabo en 40 pacientes consecutivos que han acudido a la consulta dental, y que cumplían los criterios de inclusión requeridos para el estudio. Se les ha realizado un examen periodontal y una analítica sanguínea, ...

  15. Infecção diagnosticada em diabéticos durante internação hospitalar Infection in diabetics during inpatient care

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    L.G.K. de Aguiar

    1997-12-01

    Full Text Available OBJETIVO. Analisar o perfil de processos infecciosos em diabéticos internados em um hospital geral. MATERIAL E MÉTODOS. Foram selecionados, retrospectivamente, 233 prontuários de diabéticos no período de setembro a novembro de 1990. Num total de 38 (16,3% pacientes com infecção, 76,3% (n = 29 eram do sexo feminino, com média de idade de 58,9 ± 15,3 anos, duração do diabetes de 10,8 ± 9,1 anos e predomínio do diabetes melito tipo II na amostra (86,3%, n = 33. RESULTADOS. O principal motivo de internação foi a doença macrovascular de extremidades (42%. Quarenta processos infecciosos foram estudados (dois pacientes apresentavam infecção em dois sítios. Foram realizadas culturas em 77,5% dos casos, não tendo sido observado predomínio de nenhum germe, mesmo nos diferentes sítios. A infecção urinária foi a mais freqüente (55%, n = 22, p BACKGROUND. To analyse the infectious diseases of inpatient diabetics in a general hospital. MATERIAL AND METHODS. We selected retrospectively 233 records of diabetics admitted during September, October and November 1990. There were 38 (16.3% patients with infection, age 58.9 ± 15.3 years, 29 (76.3% were female, duration of diabetes were 10.8 ± 9.1 years and 86.3% (n = 33 were possibly DM type II. RESULTS. Peripheral macrovascular disease was the main cause of admission (42%. Forty infectious processes were analysed (two patients had two sites of infection. Cultures were performed in 77.5% of the cases and no microorganism predominated, even when different sites of infection were analysed. Urinary tract infection were the most frequent one (55%, n = 22, and 86.4% (n = 19 of them were observed in female. Pulmonary infections accounted for 71.4% of the cases of sepsis which occurred in 18.4% (n = 7 of our population. All patients with sepsis died. CONCLUSION. Considering infections a worsening factor for diabetic patients we could conclude that it is important to perform some prophylatic measures to avoid them.

  16. Un caso de revisión diagnóstica de una depresión previamente diagnosticada de trastorno bipolar

    OpenAIRE

    Gavino, Aurora; Postigo Claros, Montserrat; Pérez Costillas, Lucía

    2003-01-01

    Se presenta la intervención terapéutica combinada con farmacología y psicoterapia en un caso diagnosticado previamente de trastorno bipolar. El trabajo conjunto de psiquiatra y psicólogos permitió plantear una alternativa diagnóstica y una intervención conjunta de acuerdo a la misma. El caso, dados los resultados obtenidos, muestra la necesidad, en muchas ocasiones, de plantear más de una hipótesis diagnóstica, especialmente cuando los datos conseguidos no se pue...

  17. Doença de Madelung (lipomatose cervical benigna simétrica): relato de dois casos Madelung's disease (symmetric benign cervical lipomatosis): report of two cases

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    Ricardo Pires de Souza; Ademar José de Oliveira Paes Junior; Abrão Rapoport

    2003-01-01

    Os autores relatam dois casos da doença de Madelung, que consiste em depósitos simétricos de gordura localizados no pescoço, ombros e mediastino superior, envolvendo nervos e vasos. Recomenda-se o uso da tomografia computadorizada, a qual confirma a natureza lipóide da massa, útil no estadiamento pré-operatório e acompanhamento pós-cirúrgico.The authors report two cases of patients with Madelung's disease, a symmetric fat deposit in the neck and superior mediastinum that involves nerves and v...

  18. Doença de Madelung (lipomatose cervical benigna simétrica: relato de dois casos Madelung's disease (symmetric benign cervical lipomatosis: report of two cases

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    Ricardo Pires de Souza

    2003-03-01

    Full Text Available Os autores relatam dois casos da doença de Madelung, que consiste em depósitos simétricos de gordura localizados no pescoço, ombros e mediastino superior, envolvendo nervos e vasos. Recomenda-se o uso da tomografia computadorizada, a qual confirma a natureza lipóide da massa, útil no estadiamento pré-operatório e acompanhamento pós-cirúrgico.The authors report two cases of patients with Madelung's disease, a symmetric fat deposit in the neck and superior mediastinum that involves nerves and vessels. Computed tomography can reveal the fat contents of these masses and guide preoperative staging and post-surgical follow-up.

  19. External hydrocephalus (benign extra-axial collections of infancy) - review of 15 cases; Hidrocefalia externa colecao extra-axial benigna da infancia - revisao de 15 casos

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    Machado Junior, Marcos Alberto da Costa; Matos, Paulo Engracio de; Barbosa, Veronica Aline [Fundacao Monte Tabor, Salvador, BA (Brazil). Hospital Sao Rafael. Servico de Bioimagem; Vieira, Naiara Argollo [Hospital Salvador, BA (Brazil); Vieira, Lauro Conceicao Nascimento [Fundacao Monte Tabor, Salvador, BA (Brazil). Hospital Sao Rafael. Servico de Ressonancia Magnetica; Puglio, Nadja; Bacelar, Aroldo [Fundacao Monte Tabor, Salvador, BA (Brazil). Hospital Sao Rafael

    1997-03-01

    The authors studied 15 cases of external hydrocephalus over a 7-year period (September 1987 to May 1995). External hydrocephalus is a condition in which infants with rapidly enlarging heads are found to have a MRI showing widening of subarachnoid space with mild or no ventricular dilatation. Some of the MRI were compared with those of patients with cerebral atrophy and some etiopathogenic hypothesis are presented. These findings indicate that external hydrocephalus is an age-related self-limited condition occurring in infants with open cranial sutures and that it usually resolves without intervention after the second or third year of age. (author) 21 refs., 4 figs.

  20. Wicket spikes: a case-control study of a benign eletroencephalografic variant pattern "Wicket spikes": estudo de variante eletrográfica benigna

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    MARCUS SABRY AZAR BATISTA

    1999-09-01

    Full Text Available Wicket spikes (WS are a benign eletroencephalogram (EEG variant, seen mainly in adults, during somnolence, in the temporal regions, in many clinical situations. WS can appear in trains or isolatedly, sometimes being difficult to differentiate from epileptiform activity. We reviewed 2,000 EEG's, found 65 with WS (3.25% and compared them with 65 normal EEG without WS. There was statistically significant (SS association between WS and age over 33; adolescent age was correlated to absence of WS and age over 65, to the presence of WS; there was an inverse correlation between WS and epilepsy, related to differences in age; a SS association with cerebrovascular disorders disappeared after controlling for age; a SS correlation with headache was also related to age; female predominance was not SS. There was a great variety of clinical situation associated with WS. We conclude that WS are a inespecific normal variant of the EEG that is age-related.As Wicket spikes (WS são um padrão benigno, variante da normalidade do eletrencefalograma (EEG, vistas principalmente em adultos, durante a sonolência, nas regiões temporais, em situações clínicas variadas. WS aparecem em "trens" ou isoladamente, podendo ser difícil diferenciá-las de atividade epileptiforme. Nós revisamos 2.000 EEG e encontramos 65 com WS (3,25% e os comparamos a 65 EEG 's normais sem WS. Encontramos associação estatisticamente significante (ES entre WS e idade acima de 33 anos; adolescência e ausência de WS e idade acima de 65 e presença de WS. Houve correlação inversa entre WS e epilepsia, explicada por diferenças nas médias de idade. A correlação ES entre WS e doença cerebrovascular desapareceu após controlarmos a idade. A correlação ES a cefaléia dependeu de sua relação à idade. A predominância do sexo feminino não foi ES. Houve maior variedade de situações clínicas associadas a WS. WS são uma variante normal do EEG, idade-relacionada.

  1. Kıbrıs Mülkiyet Tartışmasına Taşınmaz Mal Komisyonu Açısından Bir Bakış Cyprus Property Dispute through the Glance of Immovable Property Commission

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    Derya ÖZVERİ

    2013-07-01

    erçevesindetanımlamak amaçlanmaktadır. Ardından Kıbrıs’ta Türk ve Yunantarafların mülkiyet tartışmasına bakış açılarını da ele alınacaktır. İkitarafında müzakare masasında çok esneme payı bırakmadıkları bubakış açıları birbirinden çok farklı bir yapı da olması, uzlaşınınoluşabilmesini olanaksızlaştırdığından bu argümanlar daha da önemkazanmaktadır. Anlaşmazlığın taraflardan biri olan Türk tarafi ikibölgelilik,Yunan tarafı ise insan hakları argümanları üzerinden konuyayaklaşmaktadır. Taraflar tezlerini bu yönde savunurken, bu çalışmaAvrupa Insan Haklari Mahkemesi´nin iki önemli karari ile (LoizidouTürkiye´ye Karşı ve Xenides-Arestis Türkiye‘ye Karsi kurulmasinasebebiyet verdiği ve kararları ile bir iç hukuk yontemi olaraktüketilmesini ön-kosul olarak gösterdiği Tasinmaz Mal Komisyonu´nuincelemeye çalışacak ve artık görüşme masasında kemikleşmiş bir konuhaline gelmiş, adanın mülkiyet sorununa yeni bir umut ışığıolabileceğini tartışmayı amaçlamaktadır.

  2. Entrevistando as famílias de recém-nascidos mal-formados como proposta de avaliação e de intervenção de enfermagem - DOI: 10.4025/actascihealthsci.v26i1.1646 Interviewing the families of sick newborn babies as a proposal of - DOI: 10.4025/actascihealthsci.v26i1.1646

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    Dirce Laplaca Viana

    2004-04-01

    Full Text Available Trata-se de um estudo que buscou meios para entender como lidar com a família que vivenciou a notícia de ter um recém-nascido mal-formado. A entrevista ocorreu em um hospital público de São Paulo, em novembro de 2002, utilizando-se o Modelo Calgary de Avaliação e Intervenção na Família (MCAF/MCIF. O estudo mostrou a necessidade de intervenções construídas com a família para minimizar o impacto da notícia e para favorecer espaço para expressão de sentimentos e resolução da crise. O papel do enfermeiro como membro da equipe interdisciplinar é tentar efetivar o trabalho de ajuda à família de forma precoce, quando esta vive a difícil experiência de ter uma criança especial. A intervenção visa atuar com a família a partir da detecção do problema, utilizando a escuta ativa da comunicação verbal e não-verbal na tentativa de compreensão da situação e atuar como facilitador do processo de resolutividade da crise vivenciada.This paper is based on a study that searched ways to understand how to deal with the family who experienced the news of a sick newborn. The interview was performed in a hospital located in São Paulo, Brazil, in November of 2002 and it used the Calgary Model of Assessment and Intervention in Family (CMAF/CMIF. This study showed the need for intervention with the family to minimize the impact of receiving the news of a sick newborn, and to provide support through a conversation for resolution of the problem. The function of the nurse is to try to perform a precocious work with the family, facing the difficult experience of having a special child. The intervention aims to help the family to solve the problem, listening to the verbal and not verbal communication, searching to understand the situation with the family.

  3. Nevus sebáceo de Jadassohn: descripción de 261 casos y su asociación con otros tumores

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    Paula Andrea Arango Pérez

    2008-11-01

    Full Text Available El nevus sebáceo de Jadassohn (NSJ es una lesión congénita benigna pero por decenios se la consideró con alto potencial de malignización hacia el carcinoma basocelular (CBC, por lo que se sugería su resección precoz. Series recientes han establecido que muchas de las neoplasias diagnosticadas como malignas eran benignas. Nuestra revisión de 261 casos constituye un aporte al conocimiento del NSJ. Hasta ahora no ha habido series similares en Colombia, y en América Latina las publicaciones no superan los 60 pacientes. MATERIALES Y MÉTODOS: se analizaron 261 casos del archivo de histopatología de la Facultad de Medicina de la Universidad de Antioquia con diagnóstico de NSJ entre 1976 y 2008, incluyendo biopsias y resecciones. RESULTADOS: de los 261 pacientes, 143 eran hombres (54,8% y 118 mujeres (45,2%; la edad promedio fue de 17,4 años; el NSJ estaba presente al nacimiento en el 90,4%. La localización más frecuente fue en el cuero cabelludo (62,5%. Presentaron tumores asociados 28 pacientes: siringocistadenoma papilífero (SCAP 8 casos (3,1%, tumor del infundíbulo folicular (TIF 5 casos (1,9%. Cuatro casos fueron de CBC (1,5% con edad promedio de 40,7 años. Cuatro de 7 tumores diagnosticados previamente como CBC, fueron reclasificados como TIF. DISCUSIÓN: el SCAP fue el tumor más frecuentemente asociado, tal como aparece reportado por otros autores. En esta serie se encontró el TIF con una mayor frecuencia que en la literatura revisada. El CBC fue el único tumor maligno y se presentó solo en adultos. Los resultados de esta serie evidencian un comportamiento benigno del NSJ, por lo que se debiera replantear la necesidad de resección precoz. La revisión histológica del diagnóstico inicial demuestra que lesiones benignas pueden ser confundidas fácilmente con CBC, sobreestimando el potencial maligno de este hamartoma.

  4. Amaç ve Beklenti Karşısında Karşılaştırmalı Edebiyatın Tanı(MSal Krizine İlişkin Birtakım Tartışmalı Saptamalar Some Argumentative Determinations Regarding Diagnostic/Definitional Crisis Of Comparative Literature In Terms Of Accordance With Its Purpose And Expectation

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    Abdulhakim TUĞLUK

    2013-09-01

    Full Text Available Comparison which possesses the characteristics of critic in linewith its purposes and ambitions keeps on its actuality and differenceperception because of its argumentative position within the science ofliterature. “Comparative Literature Science” which has become effectivein literature argumentations in recent years in Turkey has not beenable to make its identity and conceptual entity acceptable, yet. Not onlythe uncertainties in the definition, but also some problems in practicekeep the questions against comparative literature in a certain level.There are also some uncertainties whether it is a method or a science initself as well as the acceptability of it by national men of literature.Comparison, which is seen as easy to do at first in terms of feasibility,shows itself as a complex process when the literal and aestheticmissions attributed by the concept to it are taken into consideration.This complexity becomes a crisis in which there are many questionswhen it is faced with diagnostic and definitive problems. On the otherhand, West-centered perception of the comparative literature and itsinternational face embracing the concept of „world literature‟(Weltliteratur make global scale expectations committed by the conceptmore argumentative rather than meeting these expectations. In thisstudy, the main starting point is gaining a certain point of view to theidentity confusion of comparative literature and establishing a generalargumentation basis. The purpose of this study is revealing somecomplex points in theory and practice considering existential problemsof comparative literature and bringing some expansion to somehandicaps regarding essence of the comparative literature. Amaç ve hedefleri doğrultusunda bir eleştiri türü niteliği taşıyan karşılaştırma, edebiyat bilimi içerisindeki tartışmalı konumu nedeniyle güncelliğini ve farklılık algısını sürdürmektedir. Türkiye‟de, son yıllarda, edebi tart

  5. Aspectos de imagem na tendinite calcária pré-vertebral

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    Caio Giometti Grassi

    2011-10-01

    Full Text Available A tendinite calcária aguda pré-vertebral é uma condição benigna e rara que apresenta calcificação das fibras do músculo longo do pescoço com reação inflamatória local, sendo esta uma das formas de apresentação menos frequentes da doença por deposição de hidroxiapatita de cálcio. Manifesta-se com dor cervical aguda e/ou odinofagia, podendo ser erroneamente diagnosticada como abscesso retrofaríngeo, espondilodiscite ou alteração decorrente de trauma. Os achados radiológicos na tendinite calcária pré-vertebral são patognomônicos. O conhecimento de tais achados é muito importante, pois o correto diagnóstico possibilita a resolução precoce dos sintomas e evita intervenções desnecessárias em um paciente que apresenta afecção com boa resposta ao tratamento conservador.

  6. Síndrome de Rett. Presentación de un caso

    OpenAIRE

    Julio Padrón González; Ramón Pérez Mejías; Lidys Padrón Fernández; Leydis Padrón Fernández

    2012-01-01

    El síndrome de Rett es un trastorno neurológico de base genética. Afecta casi exclusivamente a niñas y mujeres; la incidencia estimada en la población general es de un caso por cada 10.000 mujeres, en su tipo clásico, es de 1 por cada 15. 000 nacimientos. Su diagnóstico es descriptivo, basado en un conjunto de signos y síntomas, pero no es etiológico; el tratamiento es sintomático y de apoyo. La enfermedad, frecuentemente, suele estar mal diagnosticada como autismo o parálisis cerebral. Deb...

  7. Biología de Anopheles (Kerteszia neivai H., D. & K., 1913 (Diptera: Culicidae en la Costa Pacifica de Colombia: IV - Estructura etárea y transmisión de malaria Biologia do Anopheles (Kerteszia neivai H., D. & K., 1913 (Diptera: Culicidae na Costa do Pacífico Colombiano: IV - Estrutura etária e transmissão da malária Biology of Anopheles (Kerteszia neivai H., D. & K., 1913 (Diptera: Culicidae on the Pacific Coast of Colombia: IV - Age structure and malaria transmission

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    César Murillo B.

    1989-10-01

    Full Text Available Con el fin de determinar la dinamica de transmisión de malaria en el poblado de Charambirá (Chocó, Colombia, se estudió la estructura etárea de Anopheles neivai (reconocido vector en la Costa Pacífica con base en su estado gonadotrófico. Se recolectaron mosquitos intradomiciliarmente durante el crepúsculo vespertino con cebos humanos y aspiradores bucales. Los mosquitos recolectados se mantuvieron en cajas cilíndricas de cartón con papel humedecido y dispensadores alimenticios hasta su disección al día siguiente. De los 200 mosquitos disecados entre septiembre y octubre de 1986,68 (34% presentaban huellas de menos de tres oviposturas y los restantes (66% habían efectuado al menos tres oviposturas. La diferencia entre el primer grupo considerado como mosquitos "no infectivos" y el segundo considerado como los "potencialmente infectivos" fue altamente significativa (X² = 10,68; P = 0,001. El 1,5% de A. neivai estudiados presentaban huellas correspondientes a 10 oviposturas mostrando una marcada longevidad y múltiples alimentaciones sanguíneas. Los resultados sugieren que existe un alto riesgo de contraer malaria en Charambirá durante el crepúsculo vespertino.Com o intuito de determinar a dinâmica de transmissão da malária no povoado de Charambirá (Chocó, Colômbia, foi estudada a estrutura etária do mosquito Anopheles neivai (reconhecido vetor da Costa Pacífica com base em seu estado gonadotrófico. As coletas foram realizadas intradomiciliarmente no crepúsculo vespertino com isca humana e auxílio de tubos de sucção manual. Os mosquitos coletados foram mantidos em caixas cilíndricas de papelão, contendo papel umidecido e alimento. Dos 200 mosquitos dissecados entre setembro e outubro de 1986, 68 (34% apresentaram vestígios de menos de três oviposturas (oviposições e os demais (66% apresentavam, pelo menos, três ovipoturas. A diferença entre o primeiro grupo considerado como mosquitos "não infectantes" e o

  8. Pensar el mundo y actuar en el mundo. Del mal radical a la banalidad del mal en el pensamiento de Hannah Arendt

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    Stefania Fantauzzi

    2003-01-01

    Full Text Available These pages prove how A Raport on the Banality of Evil forces Arendt to re-think the category of Radical Evil, in which she had based The Origins of Totalitarism. She now has to use a new interpretative criteria, based on the idea of the Banality of Evil, in which the author of a series of criminal acts is not a monster but a person unable to think. The notion of the Banality of Evil rises some discussion around the meaning of conscience, and the will that this meets in the responsibility of the individual, the tool to understand and fight Evil. These questions end up converging in the analysis of a basic moral issue, the judgment, which opens new perspectives on The Life of the Mind.

  9. Quantum theory totally simply or nothing times infinity yields cosmos; Quantentheorie ganz einfach oder Nix mal unendlich mal Zeit ergibt Kosmos? PISA fuer Physiker und Mathematiker

    Energy Technology Data Exchange (ETDEWEB)

    Linzenich, Guenter

    2008-07-01

    One year ago the author presented a new unified theory, the dreamed aim of all physicists to describe all from one basic element. Now he explains by means of examples the correctness of his theory and tries to explain the great connections and make also understandable for the layman.

  10. Prospective study of fetal hydronephrosis diagnosed by ultrasound- contribution to prevent renal damage in childhood; Estudo prospectivo da hidronefrose fetal diagnosticada por ultra-som: uma contribuicao na prevencao ao dano renal na infancia

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Eduardo A.; Cabral, Antonio Carlos V.; Leite, Henrique V.; Filgueiras, Teresa F.; Oliveira, Raquel B.B.; Vilasboas, Aranai S.; Tiburcio, Arthur E.L.; Diniz, Jose Silveiro S. [Minas Gerais Univ., Belo Horizonte, MG (Brazil). Hospital de Clinicas

    1998-03-01

    Newborns with anomalies of the urinary tract detected by fetal echography were investigated. The purpose was to identify prevalent uropathies, clinical outcome and variables of prognostic significance in patients with fetal hydronephrosis. The patients were investigated by ultrasound, micturating cystourethrography and radionuclide imaging, after beginning of chemoprophylaxis. Renal function and urinary tract infection were also studied. Eight-three patients were included in this study, 54(65,1%) of these were boys. Postnatal predominant diagnosis were pelviureteric junction obstruction (3,3%) and multicytic kidney (15,7%). Follow-up average was 35 {+-} 2.5 months. Renal function deteriored in 8 children during follow-up. Worse prognosis was associated with prenatal diagnosis before third trimester of gestation, bilateral uropathy, oligohydrammios, abnormal palpable kidney or bladder, abnormal renal function on admission and urethral obstruction. (author) 40 refs., 3 figs.

  11. Endocardite por Coxiella burnetii (febre Q: doença rara ou pouco diagnosticada? Relato de caso Endocarditis due to Coxiella burnetii (Q fever: a rare or underdiagnosed disease? Case report

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    Rinaldo Focaccia Siciliano

    2008-08-01

    Full Text Available A febre Q é uma zoonose de distribuição mundial causada por Coxiella burnetii, sendo raros os registros da doença no Brasil. Estudos soroepidemiológicos mostraram uma freqüência relativamente elevada de anticorpos contra Coxiella burnetii em populações com exposição ocupacional. Em humanos, pode se manifestar clinicamente como doença aguda ou crônica, sendo que a endocardite é a forma crônica mais freqüente da febre Q e de maior morbi-mortalidade. Relatamos um caso grave de endocardite por Coxiella burnetii adquirida no Brasil com desfecho fatal, apesar de antibioticoterapia adequada e tratamento cirúrgico valvar.Q fever is a zoonosis of worldwide distribution that is caused by Coxiella burnetii. However, reports of this disease in Brazil are rare. Seroepidemiological studies have shown relatively high frequencies of antibodies against Coxiella burnetii in populations with occupational exposure. In humans, it can be manifested clinically as acute or chronic disease. Endocarditis is the most frequent chronic form of Q fever and the form with the greatest morbidity and mortality. We report a severe case of endocarditis due to Coxiella burnetii acquired in Brazil that had a fatal outcome, despite specific antibiotic therapy and valve surgery treatment.

  12. Asociación entre el volumen de grasa epicárdica y las placas coronarias diagnosticadas por tomografía multicorte/ Associationbetweenepicardialfatvolume and coronary plaques diagnosedbymultislicecomputedtomography

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    José A. Morán Quijada

    2015-12-01

    Full Text Available Introduction: Coronary atherosclerotic disease is a major cause of death in Cuba and elsewhere. The volume of epicardial fat is considered a new cardiovascular risk factor because of its association with coronary atherogenesis. Objective: To determine, by multislice computed tomography, the association between epicardial fat volume and the presence of coronary atherosclerotic plaques. Method: A descriptive study was conducted with a universe of 130 patients with chest pain suggestive of ischemic heart disease, of which 117 were selected by opinion sampling. These patients underwent a calcium score study, a coronary angiography and a measurement of the epicardial fat volume. Results: Male patients predominated (54.7% and those aged 60-69 years (32.5%. A high volume of epicardial fat was found in 51.3% of patients, affecting 52.8% of women; 78.9% of patients with a calcium score between 100 and 399 UH had a high volume of epicardial fat, just as 71.2% of those with plaques and 100% of those with 4 or 5 plaques; 41% of patients had various types of plaque, which were mainly located in the anterior descending artery (88.1%. Conclusions: The measurement of the volume of epicardial fat is a useful tool to estimate the presence of coronary disease. When it was high, it was associated with older age, female gender and the presence of a higher calcium score, more plaques, more injuries and a greater involvement of the anterior descending artery.

  13. Doenças de aves selvagens diagnosticadas na Universidade Federal do Paraná (2003-2007 Diseases of wild birds diagnosed at the Federal University of Paraná, Brazil (2003-2007

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    Gizah G.C. Santos

    2008-11-01

    Full Text Available Dentre os 253 atendimentos realizados em aves selvagens entre agosto de 2003 a agosto de 2006 no Ambulatório de Animais Selvagens do Hospital Veterinário da Universidade Federal do Paraná, 45 casos (17,8% referiram-se a consultas à espécie Serinus canarius (canário-belga. Dentre as aves atendidas e suas respectivas ordens obteve-se uma maior ocorrência da ordem Psittaciforme. As enfermidades mais freqüentemente visualizadas foram as afecções traumáticas com 56 casos (22,13%. Destas, 17 animais (30,91% possuíam algum tipo de fratura, sendo a fratura rádio-ulnar a mais comum, com 17,65% de ocorrência. As outras moléstias mais relatadas foram a presença de ectoparasitos (12,50% e endoparasitos (10,68%, doenças respiratórias (10,42%, procedimentos preventivos (7,55%, afecções dermatológicas (6,51%, neoplasias (4,95%, afecções oftálmicas (4,43%, afecções gastrintestinais (3,91%, caquexia (3,39%, afecções neurológicas (2,86%, automutilação (2,86%, obesidade (2,34%, agressão por outros animais (1,56 %, doenças nutricionais (1,30%, retenção de ovo (1,04%, bouba aviária (0,78% e gota úrica (0,52%. Tendo em vista a alta prevalência de traumatismos e presença de ecto e endo parasitas que poderiam ser evitados se estivesse ocorrendo um manejo adequado com a ave, sugere-se a necessidade que o Médico Veterinário assuma um papel mais efetivo na Medicina Veterinária Preventiva buscando informar e debater questões referentes ao modo correto de alimentação, criação e manejo das aves, assim como também o esclarecimento acerca das questões referentes às zoonoses quando da consulta veterinária.From 253 wild birds attended at the Wild Animal Ambulatory of the Veterinary Hospital, Paraná Federal University, between August 2003 and August 2006, 45 cases (17.8% were related to the species Serinus canarius (Belgian Canary. Within these attended birds and its respective orders, most morbid conditions occurred with the Psittaciforme order and were caused by traumatism, in 45 cases (14.32%. Of these, 17 animals (30.91% had bone fractures; the most common were on radius-ulna (17.65%. Other conditions were presence of ectoparasites (12.50% and endoparasites (10.68%, respiratory disease (10.42%, dermatological ailments (6.51%, neoplasms (4.95%, ophthalmic illnesses (4.43%, gastrointestinal diseases (3.91%, cachexia (3.39%, neurological diseases (2.86%, self-mutilation (2.86%, obesity (2.34%, aggression by other animals (1.56%, nutritional deficiencies (1.30%, egg retention (1.04%, avian poxvirus (0.78% and uric gout (0.52%, as well as there was clinical routine measures to be taken (7.55%. Traumas and illnesses were observed as the highest prevalence on the casuistic, which could be prevented by correct husbandry practices.

  14. Doenças de caprinos diagnosticadas na região Central no Rio Grande do Sul: 114 casos Diseases of goats diagnosed in the Central region of Rio Grande do Sul, Brazil: 114 cases

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    Fábio B. Rosa

    2013-02-01

    Full Text Available Foi realizado um estudo retrospectivo dos arquivos do LPV-UFSM e examinados os laudos de necropsias de caprinos realizadas num período de 48 anos (1964 a 2011. Foram analisados 114 laudos de necropsias de caprinos. Deste total, 95 (83,33% tinham diagnóstico conclusivo e 19 (19,66% tinham diagnóstico inconclusivo. Dos 95 casos conclusivos, as doenças infecciosas e parasitárias foram as mais prevalentes, seguidas em ordem decrescente de prevalência, pelas doenças metabólicas e nutricionais, intoxicações e toxi-infecções e alterações do desenvolvimento. Outras alterações de diferentes naturezas e etiologias que não se enquadravam nos grupos de doenças acima afetaram cerca de 10% dos caprinos examinados. A hemoncose foi a principal causa de morte de caprinos na área de abrangência do LPV-UFSM. Eimeriose e listeriose também foram causas importantes de morte. Dentre as doenças metabólicas e nutricionais, urolitíase, osteoporose, toxemia da prenhez, desnutrição e doença dos músculos brancos foram as mais prevalentes. Principalmente as doenças infecciosas e parasitárias e as metabólicas e nutricionais ocorreram muitas vezes na forma de surtos, acarretando maiores perdas econômicas associadas.A retrospective study of the goat necropsies performed over a period of 48 years (1964 to 2011 at the Laboratório de Patologia Veterinária, Universidade Federal de Santa Maria, Rio Grande do Sul (RS state, Brazil, was performed. A total of 114 reports of goat necropsies were analyzed. Ninety five necropsies (83.33% had a conclusive diagnosis and 19 (19.66% had inconclusive diagnosis. Out of the conclusive cases, infectious and parasitary diseases were the most prevalent, followed, in decreasing order of prevalence, by metabolic and nutritional diseases, poisonings and toxi-infections, and developmental diseases. Other conditions or lesions that did not fit any of the above groups of diseases affected about 10% of the necropsied goats. Hemonchosis was the most prevalent cause of death in this study. Eimeriosis and listeriosis were also important causes of goat deaths. Among the metabolic and nutritional diseases, urolithiasis, osteoporosis, pregnancy toxemia, malnutrition, and white muscle disease were the most prevalent. Mostly the infectious and parasitary diseases and the metabolic and nutritional diseases occurred many times as outbreaks, causing even more important economic losses.

  15. Prevalencia de enfermedades crónicas diagnosticadas en población inmigrante y autóctona Prevalence of diagnosed chronic disorders in the inmigrant and native population

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    María D. Esteban-Vasallo

    2009-12-01

    Full Text Available Objetivo: Estimar la prevalencia de problemas de salud crónicos en inmigrantes y compararla con la de la población autóctona, utilizando la historia clínica electrónica (HCE de atención primaria (AP. Métodos: Estudio descriptivo transversal con pacientes de 16 y más años incluidos en el sistema sanitario público de la Comunidad de Madrid. Se estimaron prevalencias ajustadas por edad para cada sexo y nacionalidad (agrupada en regiones a partir de los episodios de atención registrados en la HCE de AP con alguna anotación en 2005 o 2006. Resultados: El 36,8% de la población inmigrante presentaba alguna enfermedad crónica (55,3% de autóctonos tras ajustar por edad, con más frecuencia en mujeres y en población de origen africano y latinoamericano. Las enfermedades más prevalentes en los extranjeros fueron las alergias (tasa cruda: 10,2%, las lumbalgias (9,1%, problemas crónicos de piel (6,8% y trastornos mentales (6,4%. Conclusiones: La prevalencia de enfermedades crónicas es menor en la población extranjera y varía según el sexo y la procedencia.Objective: To estimate the prevalence rates of chronic disorders in immigrants and to compare them with those in the native population, based on electronic clinical records in primary care (ECRPC. Methods: We performed a descriptive cross-sectional study in patients aged 16 and over included in the Madrid Regional Public Health System. Age-adjusted prevalence rates for each sex and region were estimated on the basis of medically examined cases registered in the ECRPC with any new data entry made in 2005 or 2006. Results: After age-adjustment, a total of 36.8% immigrants had some chronic health problem (vs. 55.3% natives. These disorders were more frequent among women and among the population from Africa and Latin America. The highest overall prevalence rates in the foreign population were allergy (10.2% crude rate, low-back pain (9.1%, chronic skin problems (6.8% and mental disorders (6.4%. Conclusions: The prevalence rate of chronic disease is lower in the foreign population and differs according to sex and country of origin.

  16. Brucelose em bovinos com bursite cervical diagnosticada em abatedouro sob inspeção federal Brucelosis in cattle with supraspinous bursitis diagnosed in an abattoir under federal inspection

    Directory of Open Access Journals (Sweden)

    Laerte Pereira de Almeida

    2000-04-01

    Full Text Available Estudo epidemiológico tipo caso-controle realizado em Uberlândia, Minas Gerais (MG, Brasil, pesquisou a ocorrência de brucelose em bovinos com bursite cervical, abatidos no período de agosto de 1993 a julho de 1994. O diagnóstico sorológico de brucelose foi realizado mediante a prova de soroaglutinação rápida em placa. Os casos de bursite foram identificados por técnico do Serviço de Inspeção Federal (SIF, com base em características morfológicas, previamente padronizadas. Para a determinação da "Razão de Odds" e do risco atribuível entre bursite e brucelose, utilizaram-se 30 animais com o quadro e, como controle, 90 bovinos sem a patologia. Dos animais com bursite, 13,3% eram brucélicos, contra 5,6% do grupo controle (P=0,115. Dentre aqueles com brucelose e bursite, as bolsas continham fibrina (40,0% e projeções digitiformes (33,3%; apenas nas bursites dos sorologicamente negativos encontraram-se presença de pus, de nódulos e de líquido viscoso. A "Razão de Odds" encontrada entre brucelose e bursite foi da ordem de 2,61, não sendo demonstrado associação entre bursite cervical e sorologia positiva para brucelose (P>0,05. No âmbito da Saúde Pública e ocupacional, sugere-se a atenção de técnicos e profissionais, visando diminuir o risco de infecção e evitar contaminação de carcaças, equipamentos e instalações.Epidemiological study case-control type carried out in Triângulo abattoir in the city of Uberlândia in the State of Minas Gerais, Brazil, has identified the ocorrence of brucelosis in bovine with supraspinous bursitis, slaughtered from August, 1993 to July, 1994. To diagnose brucelosis "Rapid Agglutination" test was performed on plate with the padronizated antigen count considered positive over 100. The bursas examined were identified by technicians of the Federal Inspection Service based on the presence of ten standardized morphological characteristics. Using the case-control design, 30 animals identified as having supraspinous bursitis were compared with 90 animals randomly selected, without bursitis- but with other characteristics (sex, background, lot, conformation similar to those affected. All animals were, then, tested for brucelosis. Within the animals with bursitis, 13.33% were found to have brucelosis against 5.56% in the control group (P=0.115. The presence of pus, nodules and viscous fluid was found only among animals who tested negative for brucelosis. The odds ratio found between brucelosis and supraspinous bursitis was 2.61 (P>0.05. As a conclusion it’s suggested attention of technicians and profesionals employed in slaughter houses aiming to reduce the risk of human infection, as well as of carcasses, equipment and installations contamination.

  17. Historia natural de la cirrosis hepática compensada diagnosticada por elastografía hepática transitoria en pacientes coinfectados por el virus de la inmunodeficiencia humana y el virus de la hepatitis C

    OpenAIRE

    Merchante Gutiérrez, Nicolás

    2015-01-01

    Pacientes y métodos Estudio multicéntrico prospectivo de cohortes llevado a cabo en 7 hospitales andaluces. A partir de Febrero de 2006 todos los pacientes infectados por el VIH con infección crónica activa por el VHC que fueron diagnosticados de cirrosis hepática en base a la presencia de una RH ≥ 14 KPa y que no habían presentado previamente o de forma simultánea al diagnóstico de la cirrosis una descompensación de la misma fueron incluidos en este estudio. Los pacientes fueron seguidos...

  18. Estudio clínico-patológico y molecular durante la inducción, desarrollo y regresión de la hiperplasia benigna de próstata en perros Beagle

    OpenAIRE

    Gallardo de Medrano, Fanny

    2006-01-01

    Consultable des del TDX Títol obtingut de la pantalla digitalitzada La relevancia de los receptores de esteroides tanto en la próstata normal como en las diferentes patologías prostáticas es bien reconocida, pero la distribución específica de algunos de ellos en los tejidos en los diferentes compartimientos celulares de la glándula prostática canina no ha sido completamente caracterizada. Nosotros analizamos la expresión inmunohistoquímica del receptor de andrógenos (AR), receptor de es...

  19. Evaluación urodinámica con doxazocina en pacientes con hiperplasia prostática benigna (HPB. Hospital Pablo Tobón Uribe (HPTU de 1998-1999

    Directory of Open Access Journals (Sweden)

    Juan Aristizábal

    2001-04-01

    Full Text Available

    Tradicionalmente la HPB ha sido tratada quirúrgicamente, pero a
    partir de los años 80 ha aparecido una gran variedad de modalidades
    terapéuticas diferentes a la cirugía, basadas en medicamentos orales que disminuyen el tamaño de la próstata y/o los síntomas que esto genera.
    Se propone estudiar con todos los parámetros urodinámicos, la respuesta de los pacientes con HPB tratados con Doxazocina para evaluar su efecto en las curvas Flujo-Presión.

     

     

  20. Treatment of benign brain lesions True Beam radiosurgery in the first year of experience; Tratamiento de lesiones cerebrales benignas con radiocirugia en el True-Beam: Primer ano de experiencia

    Energy Technology Data Exchange (ETDEWEB)

    Lliso, F.; Carmona, V.; Gimeno, J.; Candela, C.; Bautista, J. A.; Perez-Calatayud, J.

    2015-07-01

    The purpose of the work is analyse the first year of experience in the treatment of injury brain benign with Rapid Arc in the patients treated in a throttle True Beam STX with radiosurgery who achieved an adequate level of efficiency and accuracy. (Author)

  1. Prevalência e fatores preditivos de retenção urinária diagnosticada por ultrassonografia no período pós-anestésico imediato Prevalencia y factores predictivos de retención urinaria diagnosticada por ultrasonido en el período postanestésico inmediato Prevalence and predictive factors of urinary retention assessed by ultrasound in the immediate post-anesthetic period

    Directory of Open Access Journals (Sweden)

    Adilson José Dal Mago

    2010-08-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Retenção urinária é uma condição frequente na sala de recuperação pós-anestésica (SRPA. Sobredistensão vesical e consequente lesão do detrusor da bexiga são situações passíveis de prevenção. A ultrassonografia permite medida confiável do volume urinário, determinando a prevalência da distensão vesical pós-operatória. Este estudo teve como objetivo determinar a prevalência de retenção urinária pós-operatória e identificar fatores independentes de previsão de sua ocorrência. MÉTODO: Prospectivamente, foram incluídos no estudo 257 pacientes admitidos na SRPA. As variáveis coletadas incluíram: idade, sexo, estado físico, local da cirurgia, tipo de anestesia, tempos cirúrgico e anestésico, uso ou não de opioides, volume de fluidos administrados, história prévia de sintomas urinários. Medidas do volume vesical foram feitas, por ultrassonografia, na admissão e na alta da SRPA. O critério para caracterizar retenção urinária foi: volume vesical igual ou maior que 600 mL, associado à incapacidade de micção espontânea 30 minutos após o diagnóstico. Análises univariadas e multivariadas foram utilizadas para identificar os fatores preditivos independentes. RESULTADOS: Ocorreu retenção urinária em 19 pacientes (7,39%. Os fatores preditivos independentes identificados foram o volume urinário igual ou maior que 360 mL na admissão à SRPA (Qui-quadrado de Mantel-Haenszel (1 gl = 18,76; p JUSTIFICATIVA Y OBJETIVOS: La retención urinaria es una condición frecuente en la sala de recuperación postanestésica (SRPA. La sobredistensión vesical y la consecuente lesión del detrusor de la vejiga son situaciones que se pueden prevenir. El ultrasonido permite una medida confiable del volumen urinario, determinando la prevalencia de la distensión vesical postoperatoria. Este estudio tuvo el objetivo de determinar la prevalencia de retención urinaria postoperatoria e identificar los factores independientes de previsión para su aparecimiento. MÉTODO: Doscientos cincuenta y siete pacientes admitidos en la SRPA fueron prospectivamente incluidos en el estudio. Las variables recolectadas incluyeron: edad, sexo, estado físico, local de la cirugía, tipo de anestesia, tiempos quirúrgico y anestésico, uso o no de opioides, volumen de fluidos administrados, e historial previo de síntomas urinarios. Las medidas del volumen vesical fueron realizadas por ultrasonido, en la entrada y en el alta de la SRPA. El criterio para caracterizar la retención urinaria fue el volumen vesical igual o mayor que 600 mL, asociado a la incapacidad de micción espontánea 30 minutos después del diagnóstico. Los análisis univariados y multivariados fueron utilizados para identificar los factores predictivos independientes. RESULTADOS: Ocurrió una retención urinaria en 19 pacientes (7,39%. Los factores predictivos independientes identificados fueron el volumen urinario igual o mayor que 360 mL en la admisión a la SRPA (Cui-cuadrado de Mantel-Haenszel (1 gl. = 18,76; p BACKGROUND AND OBJECTIVES: Urinary retention is a common condition in the post-anesthetic care unit (PACU. Vesical overdistension and consequent damage of the detrusor muscle of the urinary bladder represent situations that can be prevented. The ultrasound allows the reliable measurement of the urinary volume, determining the prevalence of postoperative vesical distension. The objective of the present study was to determine the prevalence of postoperative urinary retention and identify independent predictive factors. METHODS: Two-hundred and fifty-seven patients admitted to the PACU were included prospectively in this study. Parameters collected included: age, gender, physical status, site of surgery, type of anesthesia, time of the surgery and anesthesia, use of opioids, volume of fluids administered, and history of urinary symptoms. Vesical volumes were measured by ultrasound after admission and upon discharge from the PACU. The criteria to characterize urinary retention were: vesical volume equal or higher than 600 mL associated with incapacity of spontaneous micturition for 30 minutes after the diagnosis. Univariate and multivariate analyses were used to indentify independent predictive factors. RESULTS: Urinary retention was observed in 19 patients (7.39%, independent predictive factors identified included urinary volume equal to or greater than 360 mL upon admission to the PACU (Mantel-Haenszel Chi-square test (1 dF = 18.76; p < 0.01, with an odds ratio of 9.82 (95% confidence interval = 3.26-29.55 and surgeries of the lower limbs (Mantel-Haenszel Chi-square test (1 dF = 5.33; p = 0.02, with odds ratio of 4.33 (95% confidence interval = 1.34-14.02. CONCLUSIONS: Due to the prevalence of urinary retention, we suggest that a systematic evaluation of the urinary volume at the PACU should be done, especially in those patients with predictive factors.

  2. Motivace v řízení malé firmy

    OpenAIRE

    Pospíchalová, Eva

    2011-01-01

    This thesis divides into two parts. The first part is theoretical, which are characterized and defined concepts, which are related to the topic of "motivation in management of the small business. The second part examines the follow-up in the company DE.PO.NA PRAHA, s.r.o. their motivation processes. What is their motivation to active employees. The opinion of the leadership´s motivation in this enterprise, as well as feedback from staff. Finally, these information are presented here evalua...

  3. Esperanzas zozobradas. Apuntes de la primera mitad del siglo xx: El siglo empieza mal

    Directory of Open Access Journals (Sweden)

    Gert Hoffmann

    2009-12-01

    Full Text Available En el presente artículo se relata la historia de vida de un excombatiente austriaco de la Guerra Civil española por el bando republicano hasta su retirada del frente tras la batalla del Ebro. Se expondrán las circunstancias de su nacimiento, concienciación política y participación en el conflicto que asoló España durante tres años. En primer lugar, se destacará la importancia de la I Guerra Mundial para la comprensión de la vida en Austria hasta el Anschluss y en concreto el frente italiano como punto de inflexión tanto para la balanza de la victoria como de la definitiva derrota del imperio austro-húngaro. En segundo lugar, se relatarán las tensiones y hechos de violencia social vividos en Austria en los días previos al Anschluss, la militancia política del autor y su decisión de ingresar en las Brigadas Internacionales para venir a combatir a España. Finalmente, se describirá el proceso de reclutamiento y viaje a la Península Ibérica para terminar la narración de su participación en la contienda con la batalla del Ebro y su posterior salida tras la orden gubernamental del 23 de septiembre de 1938.___________________ABSTRACT:This article deals with the history of life of an Austrian ex-combatant of the Spanish Civil War by the republican side, until his retire after the Battle of the Ebro. Circumstances of his birth, political awareness and participation in the Spanish Civil War, that will knock down Spain during three years, are here shown. Firstly, it will be explained the importance of the I World War for the understanding of the life in Austria until the Anschluss, and the meaning of the Italian front as a turning point for the victory or the defeat of the Austro-Hungarian Empire. Secondly, tensions and episodes of social violence occurred in Austria in the first days of the Anschluss, will be described: the author's political militancy and his decision of joining the International Brigades for fighting in Spain, are also pointed up. Finally, the recruitment process and his voyage to Spain are described and his narration ends with his participation in the Battle of the Ebro and his consequent quit after the September 23, 1938 governmental order.

  4. Percepce a image malých měst

    Czech Academy of Sciences Publication Activity Database

    Frantál, Bohumil; Pokluda, František

    Brno: Regiograph, 2004 - (Vaishar, A.), s. 174-183 ISBN 80-86377-12-1 R&D Projects: GA AV ČR IAA3086301 Institutional research plan: CEZ:AV0Z3086906 Keywords : perception * city in mind * image * small towns * urban liveability Subject RIV: AO - Sociology, Demography

  5. Metabolismo do ácido fólico na malária

    Directory of Open Access Journals (Sweden)

    Aymoré Vaz Pinto

    1983-06-01

    Full Text Available O estudo de 27 pacientes infectados pelo Plasmodium falciparum comparado com pessoas aparentemente sadias mostra: a diminuição do folato no soro dos pacientes infectados; b diminuição do folato sêrico nos primeiros 8 dias que seguiram ao tratamento, interpretados como sendo devido à mobilização pela eritropoiese compensadora; c folato eritrocítico normal.

  6. Analýza možností propagace malé firmy na internetu

    OpenAIRE

    Beránek, Jakub

    2013-01-01

    The bachelor thesis deals with the possibilities of promoting small business on the Internet and analyses the results of the different channels used to realize the advertising. Websites were created to a company. These internet pages are different from the competition on the website, for example you can book a massage. Advertising is realised using the following channels: PPC advertising, banners, SEO, Facebook, discount vouchers,... Although this is a specific product (massage, specializing ...

  7. Chronic aflatoxin exposure in children living in Bhaktapur, Nepal: Extension of the MAL-ED study

    Science.gov (United States)

    Fumonisin B1 (FB1) and aflatoxin B1 (AFB1) are toxic chemicals produced by molds. The molds that produce these two toxic chemicals are commonly found in corn and their co-occurence in corn has been demonstrated in many surveys. This study was conducted because it is suspected that exposure to eith...

  8. Personální práce v malém podniku

    OpenAIRE

    Látalová, Silvie

    2010-01-01

    This thesis focuses on the topic of human resources management in a small business. The goal of the thesis is to analyze human resources management in a small business PAT, show their strengths and weaknesses and eventually suggest some corrective steps. In the theoretical part after the terms human resources management and small business are defined, the differences between human resources management in a small and in a large business are described as well as individual human resources activ...

  9. PERSPECTIVES ON FUTURE EFL COMMUNICATIVE ENVIRONMENTS BY E-MAlL AND INTERNET IN CHINESE UNIVERSITIES

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    E-mail-assisted language teaching is at the fore-front of the advances in educational tools in EFLteaching.But is it possible to create EFL communica-tive environment by E-mail and Internet in Chineseuniversities?Can we totally adopt CA by E-mail andInternet in Western countries into Chinese universi-ties?It is evident that Completely transferring it toChinese educational context is irrational and will ulti-mately fail.Thus,success depends on reconciling E-mail-assisted EFL teaching with traditional Chineseapproaches.This paper is designed to make perspec-tives on this reconciliation,and presents some disad-vantages of using E-mail and Internet in teaching.

  10. Dießmal Schlesien, Cleve, Sachsen, Pfalz und die Schweiz betreffend

    OpenAIRE

    Riem, Johann

    2006-01-01

    Teil von: Johann Riem's physikalisch-ökonomische Bienenbibliothek, oder Sammlung auserlesener Abhandlungen von Bienenwahrnehmungen und ausführliche Urtheile über ältere und neuere Bienenbücher / Johann Riem ; 3. Anhang bildet--> Riem, Johann: Johann Riem's Geprüfte Grundsätze der schlesischen Bienenpflege

  11. František Kupka - malíř mezi kanóny

    Czech Academy of Sciences Publication Activity Database

    Pravdová, A.; Winter, Tomáš

    2012-01-01

    Roč. 34, č. 10 (2012), s. 32-35. ISSN 0418-5129 Institutional research plan: CEZ:AV0Z80330511 Keywords : Czech fine art of 20th century * caricature * propaganda Subject RIV: AL - Art, Architecture, Cultural Heritage

  12. Sediments and archeological findings of abounded brickyyard at Malá nad Hronom, Slovakia

    Czech Academy of Sciences Publication Activity Database

    Szeberényi, J.; Bradák, B.; Józsa, S.; Kiss, K.; Markó, A.; Medveďová, A.; Megyeri, M.; Molnár, M.; Roštínský, Pavel; Szakmány, G.; Szmánda, J.; Varga, V.

    Vol. 1. Budapest: Hungarian Geographical Society, 2015 - (Eröss, A.; Heiling, Z.; Kovács, J.; Mari, L.; Mohai, A.; Sik, A.; Zimay, K.). s. 240-240 ISBN 978-615-80307-0-0. [EUGEO 2015 – Budapest (within Association of geographical societies in Europe). 30.08.2015-02.09.2015, Budapest] Institutional support: RVO:68145535 Keywords : fluvial terrace * loess * Pleistocene Subject RIV: DE - Earth Magnetism, Geodesy, Geography

  13. Web-marketing mix 4S v malé organizaci

    OpenAIRE

    Uhlíř, Petr

    2011-01-01

    The goal of this thesis is to evaluate whether application of the model of marketing promotion in the Internet based on the concept of web-marketing mix 4S in a small organization, sales-oriented professional machines and equipment for carpentry, plumbing and metal fabrication shop can achieve synergy and formulated key performance indicators. To achieve this goal is necessary to identify and describe technologies, tools, procedures and processes based on literature and publications that are ...

  14. Un modelo computacional de reacciones relacionadas con el mal de Alzheimer en el nivel molecular

    OpenAIRE

    Annia Galano Jiménez; Luis A. Montero Cabrera; Raúl Álvarez Idaboy; Addis Londaitsbehere Trujillo; José C. García Piñeiro

    2002-01-01

    El desarrollo tecnológico de los medios de cómputo ha hecho posible que se estudien sistemas cada vez mayores y con mayor grado de exactitud. El método empleado es el llamado semiempírico con la parametrización PM3 implementado en el programa MOPAC. En este trabajo se modeló la ruptura de los diferentes enlaces del carbono a, así como la del enlace peptídico. Los cálculos fueron hechos en procesadores Pentium Pro (200 MHz, 64 bytes RAM), Dual Pentium II (233 MHz, 128 bytes RAM), Dual Pentium ...

  15. Návrh malé vodní nádrže

    OpenAIRE

    Galuška, Martin

    2016-01-01

    Práce se zaměřuje na vypracování zjednodušeného návrhu vodohospodářského a konstrukčního řešení v lokalitě Bezměrov. V části teoretické jsou stručně popsány základní funkční objekty nádrže. Samotná práce je pak založena na vyhodnocení morfologie terénu z dodaných podkladů ve formě vrstevnic a geologických sond a následném návrhu řešení suché retenční nádrže. V rámci výkresové části bude využito výstupů z programu PowerCivil, ve kterém bude pomocí digitálního modelu terénu vytvořeno směrové ře...

  16. Nasazení Google Apps for Work v malé firmě

    OpenAIRE

    Hrubý, Jakub

    2014-01-01

    This diploma thesis deals with a product Google Apps for Work as a cloud-based tool for businesses. The main idea of this work is to describe the offered service and to deploy it to a real company on the Czech market, belonging to the sector of small and medium-sized companies. The theoretical part is based on a literature review of technical books, articles, and other electronic sources. The subsequent description and evaluation of the implementation is based on real-world knowledge in deplo...

  17. Problematika malých obcí z pohledu geografa

    Czech Academy of Sciences Publication Activity Database

    Klusáček, Petr

    Brno: Institut regionálních informací, s.r.o, 2008, s. 1-5. ISBN 978-80-254-2421-6. [ProREGIO 2008 - Udržitelný rozvoj regionů, měst a venkovských sídel. Brno (CZ), 11.11.2008-12.11.2008] Institutional research plan: CEZ:AV0Z30860518 Keywords : small municipalities * executive powers * distribution of taxes * public administration reform Subject RIV: AO - Sociology, Demography

  18. Finanční analýza malého podniku

    OpenAIRE

    Šefčíková, Adéla

    2013-01-01

    The study deals with financial analysis and its methods. The theoretical part is devoted to findings of financial analysis, resources and description of its methods. In the practical part is realized financial analysis of developed business enterprise Zebra, Ltd. and evaluated methods that have been used in the analysis. The practical part also deals with the evaluation presentation of the financial statements, from which data are obtained for the realization of financial analysis.

  19. Le temps de la fatigue : La gestion sociale du mal-être au travail

    OpenAIRE

    Loriol, Marc

    2000-01-01

    Il est de plus en plus courant aujourd'hui de se plaindre d'une " mauvaise fatigue " dont seraient responsables les conditions de vie modernes. L'ambition de ce livre est d'articuler une approche historique longue qui inscrit cette notion de mauvaise fatigue dans le processus de civilisation défini par Norbert Elias (l'autocontrôle des émotions et les nouvelles régulations s'accompagnent d'une individualisation et d'une autonomie qui rendent plus sensibles les défaillances individuelles) et u...

  20. Rozvoj kultury v malé obci Středočeského kraje

    Czech Academy of Sciences Publication Activity Database

    Vojtíšková, Kateřina

    2013-01-01

    Roč. 5, č. 2 (2013), s. 143-160. E-ISSN 1803-8220 R&D Projects: GA MK DF11P01OVV032 Keywords : local culture * regional development * citizen participation Subject RIV: AE - Management ; Administration http://acpo.vedeckecasopisy.cz/publicFiles/00462.pdf

  1. FENOMENA BANGUNAN MAL DAN PENGALAMAN ESTETIKA BAGI MASYARAKAT URBAN DI JAKARTA

    OpenAIRE

    Amarena Nediari; Christophorus Purwana

    2013-01-01

    Mall building has become part of the urban livings lifestyle. Going to the mall is an independent necessity without any emotional bond with others. As a public area, mall has been trying to fulfill urban communities needs such as to enlarge employment opportunities as well as to provide an entertainment center for visitors. For most of urban communities, mall is considered to be a solution for all members of family. It is one destination for all. Mall elements consist of anchor, secondary anc...

  2. [Hesla malířů, architektů a stavitelů

    Czech Academy of Sciences Publication Activity Database

    Vlček, Pavel

    Praha: Libri, 2001 - (Richter, J.), s. 27-515 ISBN 80-85983-87-7 Institutional research plan: CEZ:AV0Z8033913 Keywords : Czech Lands * personalities * visual artists Subject RIV: AL - Art, Architecture, Cultural Heritage

  3. Kreativní účetnictví malých podniků

    OpenAIRE

    Hübnerová, Eva

    2012-01-01

    The diploma thesis deals with the creative accounting of small enterprises in the Czech accounting practice. Natural effort of companies is a tax reduction. Therefore the techniques of creative accounting in the thesis are divided by whether the company is trying to manipulate the accounting data for tax or non-tax reasons. Theoretical description of techniques of creative accounting is completed cases of findings the tax offices. In conclusion of the thesis there are suggested possible solut...

  4. Strategie malých a středních podniků

    OpenAIRE

    Jehlička, Tomáš

    2015-01-01

    The goal of the master thesis is to execute a strategic analysis of Výzva 21 dní, s.r.o., considering the need of restructuring steps and proposal of corporate strategy for the company. The task of the theoretical part is to explain the basic terms of the strategic management in small and medium-sized enterprises. The practical part is devoted to a strategic analysis of the company Výzva 21 dní, s.r.o. The key methodologies used are Porter's five competitive forces analysis and PESTE analysis...

  5. Human milk as a source of tumor killing molecules. From MAL to HAMLET.

    OpenAIRE

    Mossberg, Anki

    2010-01-01

    HAMLET (Human alphalactalbumin made lethal to tumor cells), a complex between the partially unfolded alphalactalbumin and oleic acid, was discovered by serendipity when anti-adhesive properties of human milk were examined. HAMLET kills tumor cells but not healthy differentiated cells. Native alphalactalbumin (HLA) can be conveted to HAMLET by a two-step process including: 1) calcium ion removal inducing a teritary change of the protein structure. 2) incorporation of oleic acid into the apo...

  6. Metafísica do irracional – mal radical em Schelling e Schopenhauer

    Directory of Open Access Journals (Sweden)

    Barboza, Jair

    2009-01-01

    Full Text Available Este artigo intenta mostrar as bases conceituais de uma metafísica do irracional em Schelling e Schopenhuaer, quando ambos os autores identificam na vontade a essência cega e irracional do mundo.

  7. Návrh marketingové strategie malé firmy - Penguin cz

    OpenAIRE

    Vu, Thanh Nhan

    2010-01-01

    This thesis concerns a proposal of marketing strategy of the company Penguin CZ. The first part is about the theory of the topic of the Bachelor's thesis. It deals with the marketing of small and medium firms, marketing strategy and marketing mix. I drew mostly from this books: Marketing by Mrs. Bouckova, Marketing management and planning for small and medium firms from Mrs. Blazkova, Marketing services: an efficient and modern by Mrs. Vastikova, Marketing and management of small and medium f...

  8. Mal d'archive : on the growth of Gunter Demnig's Stolperstein-project.

    OpenAIRE

    Osborne, Dora

    2014-01-01

    In Archive Fever, Derrida opens a critical perspective on the status of the trace as that which remains with his reading of Gradiva, the Pompeian fantasy woman who is supposed to have left her singular toe-print in the ash of Vesuvius. This article returns to the figure of Gradiva as emblem for the non-coincidence of origin and trace, in order to outline the (increasingly troubling) archival aspects of Gunter Demnig's Stolperstein-project, a large-scale, decentralized memorial commemorating t...

  9. « La banalité du mal » selon Eduardo Pavlovsky

    Directory of Open Access Journals (Sweden)

    Isabelle Clerc

    2013-03-01

    Full Text Available Dans El señor Galíndez (1973 et Potestad (1985, le dramaturge argentin Eduardo Pavlovsky met en scène la figure d’un tortionnaire humain. Ces pièces bousculent la norme. Comment accepter en effet que la torture et l’enlèvement d’enfants durant la dictature argentine ne soient pas l’œuvre de monstres mais de gens ordinaires ? Nous nous proposons de voir les mécanismes de la rupture dans ces pièces, et d’en analyser la portée.

  10. Malá povodí a jejich význam

    Czech Academy of Sciences Publication Activity Database

    Tesař, Miroslav

    Vesmír s.r.o.. Roč. 90, č. 9 (2011), s. 508 ISSN 0042-4544 Institutional research plan: CEZ:AV0Z20600510 Keywords : small catchments * water balance * monitoring Subject RIV: DA - Hydrology ; Limnology

  11. "Leuchten wir mal hinein...": Das Waldhaus Charlottenburg in Sommerfeld/Osthavelland 1905-1945

    OpenAIRE

    Schmitt, Andreas

    2010-01-01

    The thesis shows the history of the Tuberculosis Hospital "Waldhaus Charlottenburg" near Berlin in Sommerfeld / Osthavelland for over three epoches. According to their importance not only medical but politic, economic, social and medical aspects of the tuberculosis disease were discussed for each period. On the base of the social reforms the magistrat of Charlottenburg/Berlin developed a modern health management already in the beginning of the 20Th Century. Detailed plannings and drafts for a...

  12. Využití Internetu pro marketing malé firmy

    OpenAIRE

    Beneš, Pavel

    2011-01-01

    My diploma thesis addresses the usage of the internet for marketing of small-scale enterprises in our surroundings. My goal is to analyse the internet environment and the possibilities of its use for marketing purposes. The analysis of internet utilities is also included. There is one case study of small-scale enterprise with appropriate conclusions in the final part of my diploma thesis. My thesis is divided into two parts. In the first part I created theoretical footholds for my thesis and ...

  13. Mal tiempo, tiempo maligno, tiempo de subversión ritual. La temposensitividad agrofestiva invernal

    OpenAIRE

    Del Campo Tejedor, Alberto

    2006-01-01

    In the light of a number of festive, ritual, poetico-musical and literary expresions, from Andalusia and elsewhere, the author discusses time as lived by agrarian cultures: a syncretic time, resulting from the superposition of civico-political, religious and peasant calendars; a cyclic time, given the effects of astronomico-meteorological time on nature and the subsequent cultural response on both the instrumental dimension (the work in the fields) and the expresive dimension (the rituals and...

  14. Monitoring malého vodního útvaru Zalužanský potok

    OpenAIRE

    Jelínek, Václav

    2013-01-01

    The paper dealt with evaluation of the rivers in the area of Teplice. During the investigation were monitored eleven small streams. Located and described the sources of pollution, building channelization, bottom substrate, migration barriers and the presence of aquatic plants. Based on field measurements, it was stated that most of the streams in the study area is the common description: Above is a pure agglomerations close to natural water flow, compared to the section under agglomeration...

  15. Monitoring malého vodního toku - Bouřlivec

    OpenAIRE

    Marešová, Gabriela

    2013-01-01

    My final thesis deals with detailed monitoring of antropoligical influence on small river Bouřlivec in Teplice zone on the base of Krušné hory. It is almost 10km long part of watercourse in where were recorded and evaluated specific sources of pollution, stream types, course barriers, botnic organisms and general overview of shores. Detailed monitoring was made on behalf of Czech fishing union in relation with prevence of further water polluting and monitoring quality of revitalizing interven...

  16. Malíř Carl Spitzweg a jeho pražská agenda

    Czech Academy of Sciences Publication Activity Database

    Prahl, Roman

    Brno : Masarykova univerzita, 2009 - (Kroupa, J.; Šeferisová Loudová, M.; Konečný, L.), s. 363-368 ISBN 978-80-210-4972-7. - (Spisy Masarykovy univerzity v Brně, Filozofická fakulta. 382) R&D Projects: GA AV ČR IAA800330602 Keywords : painting * exhibitions * Czech lands * 19th century Subject RIV: AL - Art, Architecture, Cultural Heritage

  17. Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de Meleda

    DEFF Research Database (Denmark)

    Chimienti, Fabrice; Hogg, Ronald C; Plantard, Laure;

    2003-01-01

    in signal transduction, immune cell activation or cellular adhesion. The high degree of structural similarity between SLURP-1 and the three fingers motif of snake neurotoxins and Lynx1 suggests that this protein interacts with the neuronal acetylcholine receptors. We found that SLURP-1 potentiates...... the human alpha 7 nicotinic acetylcholine receptors that are present in keratinocytes. These results identify SLURP-1 as a secreted epidermal neuromodulator which is likely to be essential for both epidermal homeostasis and inhibition of TNF-alpha release by macrophages during wound healing. This...

  18. Podnikatelský projekt - malá vodní elektrárna

    OpenAIRE

    Pytolajová, Eliška

    2013-01-01

    The aim of the bachelor thesis" The business plan – the small hydropower plant" is to make a proposal of business plan to establish a small hydropower plant in the town of Litovel. The bachelor thesis is divided into two parts.The theoretical part defines the term business plan and describes individual sections of the plan. Also, the reader should become acquainted with basic information about small hydropower plants and about options of obtaining funds from European Union funds. The pract...

  19. Vlastivědná mapa malého územního celku

    OpenAIRE

    Karlíková, Eliška

    2014-01-01

    Diplomová práce se zabývá analýzou mapového obsahu vybraných historických a současných kartografických děl, zobrazujících území Blovicka a tvorbou vlastivědné mapy této oblasti. V teoretické části je, kromě základů kartografie a vlastivědných map, také definováno a popsáno zájmové území. Praktická část obsahuje popis provedených analýz vývoje zeměpisných jmen, mapových znaků a krajiny a popis tvorby vlastivědné mapy Blovicka. Součástí práce jsou tabulky související s analýzami mapového obsahu...

  20. Hodnocení zaměstnanců v malém podniku

    OpenAIRE

    Klattová, Lucie

    2015-01-01

    The bachelor thesis is focused on analysing the contemporary state of employee's evaluation in concrete small business XY s.r.o. continuing with designing the new system of evaluation and finally on description of implication. The aim of the thesis is creating the educating material for management of XY s.r.o.. Methods of data collecting are studied specialised literature, unstructured interviews with XY s.r.o.'s management, the analysis of internal documents and two questionnaires - for part...