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Sample records for benigna mal diagnosticada

  1. Hiperplasia Benigna da Próstata

    OpenAIRE

    Fuente de Carvalho, J; Sismeiro, A; Campos Pinheiro, L; Catalão Castro, MT; Carmona Luís, MJ; Abreu, MJ; Mendes Silva, M

    2001-01-01

    Os autores fazem a revisão da clínica, do registo da sintomatologia e impacto na qualidade de vida, dos meios auxiliares ao diagnóstico e das atitudes terapêuticas da Hiperplasia benigna da Próstata. Fundamentados nestes dados propõem Orientações Terapêuticas e Recomendações, para quando e como enviar os doentes portadores desta patologia a Urologia. Assim, segundo os critérios definidos neste trabalho, devem ser enviados à Urologia os doentes com sintomatologia importante ou grave, idade ...

  2. Vertigem de posicionamento paroxística benigna

    OpenAIRE

    Pereira Cristiana Borges; Scaff Milberto

    2001-01-01

    A vertigem de posicionamento paroxística benigna é um distúrbio vestibular de diagnóstico fácil, baseado no exame neurológico e tratado com manobras de liberação. Nesta revisão, a fisiopatologia, os aspectos clínicos e as diferentes manobras são sucintamente discutidos.

  3. Memoria del mal

    Directory of Open Access Journals (Sweden)

    Semprún, Jorge

    2011-06-01

    Full Text Available In May 2003 the twelfth edition of the «Aranguren Conferences» was held. Jorge Semprún gave three keynote speeches titled «Kant and the Maquis’ rucksack», «The radical evil and the Buchenwald latrines» and «Literature and memory of the evil: from Sartre to Paul Ricoeur», all of them grouped under the generic denomination Memory of Evil. The thread running through the three speeches was Semprún’s experience as a political deportee at Buchenwald concentration camp, so close to the Weimar camp of Schiller and Goethe. There, he could experience the radical evil, but also the brotherhood through the antifascist resistance groups who coordinated the various clandestine political groups at the camp. This experience helped him review some of the philosophical readings he had done as a philosphy student at the Sorbonne, as well as those readings he took an interest in following the end of the war. In this way, Semprún went over various authors (Immanuel Kant, André Malraux, Edmund Husserl, Jacques Maritain, Martin Heidegger, Karl Marx, Hannah Arendt, Jean Paul Sartre, Paul Ricoeur or Primo Levi arguing their relationship with the issue of Evil.

    En mayo de 2003 se celebró la duodécima edición de las «Conferencias Aranguren». Jorge Semprún dictó tres conferencias magistrales tituladas «Kant y la mochila del maquis», «El mal radical y las letrinas de Buchenwald» y «Literatura y memoria del mal: de Sartre a Paul Ricoeur», agrupadas todas ellas bajo el título genérico de Memoria del mal. El hilo conductor de las tres intervenciones fue la experiencia de Semprún como deportado político en el campo de concentración de Buchenwald, tan cercano al Weimar de Schiller y Goethe. Allí pudo experimentar el mal radical, pero también la fraternidad, a través de los grupos de resistencia antifascista que coordinaban en el campo los distintos grupos políticos clandestinos. Esta experiencia le sirvió para repasar las lecturas

  4. Lipomatosis simétrica benigna de la lengua en la enfermedad de Madelung Benign symmetric lipomatosis of the tongue in Madelung’s disease

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    A. López Ceres

    2006-04-01

    Full Text Available La enfermedad de Madelung, o lipomatosis simétrica benigna es una enfermedad rara caracterizada por acúmulos grasos no encapsulados localizados de forma simétrica alrededor de cuello y hombros. Esta enfermedad, afecta predominantemente a hombres en edades comprendidas entre los 30 y 60 años, con una relación hombre:mujer de 15:1. Existe una gran relación con el abuso del alcohol. Las personas no alcohólicas y las mujeres también pueden verse afectadas, aunque de forma más rara. Presentamos el caso de una mujer diagnosticada de Enfermedad de Madelung refiriendo engrosamiento progresivo de la lengua. Presentaba dificultad para tragar, disartria y disnea con el decúbito.Madelung´s disease, or benign symmetric lipomatosis, is an uncommon disease characterized by non-encapsulated accumulations of fat in a symmetric manner around the neck and shoulders. This uncommon disease predominantly affects men between the ages of 30 and 60 and it has a 15:1 ratio. There is a strong correlation with alcohol abuse. Nonalcoholics and women can also be affected although this is rare. We report the case of a woman diagnosed with Madelung’s disease, who described a gradual swelling of the tongue. She had difficulty swallowing, dysarthria and dyspnea while sleeping.

  5. Para todo mal, a cura

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    Maria Borges

    2014-11-01

    Full Text Available Nesse artigo, eu apresento a teoria kantiana do mal. Mostrarei que Kant divide o mal em três níveis: fraqueza, impureza e perversidade, relacionando-os com afetos e paixões. Eu defendo que Kant apresenta várias formas de curar o mal nos diversos textos, tais como Doutrina da Virtude, Antropologia, Ideia para uma história universal do ponto de vista cosmopolita e Religião nos limites da simples razão. Eu tentarei mostrar que a virtude é impotente para curar o mal e que Kant apresenta uma comunidade ética para esse fim. Por fim, eu compararei a construção de comunidade ética com o estabelecimento de uma sociedade civil jurídica

  6. El Gobierno del mal menor

    DEFF Research Database (Denmark)

    Agustin, Oscar Garcia

    2012-01-01

    El Gobierno no aspira a ser bueno ni malo. Se conforma con ser el Gobierno del mal menor, cuyas medidas drásticas y poco populares están destinadas a salvar a los ciudadanos del desastre que no ha llegado todavía pero podría llegar.......El Gobierno no aspira a ser bueno ni malo. Se conforma con ser el Gobierno del mal menor, cuyas medidas drásticas y poco populares están destinadas a salvar a los ciudadanos del desastre que no ha llegado todavía pero podría llegar....

  7. EFECTO DE Tropaeolum tuberosum FRENTE A LA HIPERPLASIA PROSTÁTICA BENIGNA INDUCIDA EN RATAS HOLTZMAN

    OpenAIRE

    Gioliana Aire-Artezano; Roma Charaja-Vildoso; Helen De La Cruz-Santiago; Beatriz Guillermo-Sánchez; María Gutarra-Vela; Pamela Huamaní-Charagua; Gricel Jesús Chilquillo; Minorka Nicho-Póvez; Madelaine Ochoa-Gago; Rosa Pari-Ñaña

    2013-01-01

    Objetivo: Evaluar el efecto de Tropaeolum tuberosum(mashua) frente a la Hiperplasia Prostática Benigna (HPB) y compararlo con finasterida. Métodos: Estudio experimental completo. Se emplearon 30 ratas Holtzman macho de 12 semanas de edad, aleatorizadas y divididas en seis gru- pos: grupo blanco; grupo testosterona; grupo finasterida (0.33mg/kg/rata); y tres grupos dosis, dosis 1 (300mg/kg/rata), dosis 2 (500mg/kg/rata) y dosis 3 (800mg/kg/rata) tratados con Tropaeolum tuberosum. Se realizó un...

  8. Indicadores de calidad en hiperplasia benigna de próstata. Un estudio cualitativo

    OpenAIRE

    Jorge Navarro-Pérez; Salvador Peiró; Francisco Brotons-Muntó; Emilio López-Alcina; Arcadio Real-Romaguera

    2014-01-01

    Objetivo: Valorar posibles indicadores de calidad de la atención a la hiperplasia benigna de próstata (HBP) y sus fortalezas y debilidades para su incorporación a los sistemas de información sanitaria. Diseño: Reunión de expertos, estructurada siguiendo procedimientos adaptados de las técnicas de grupo nominal y método de consenso Rand. Emplazamiento: Escuela Valenciana de Estudios de la Salud. Participantes y/o contextos: Participaron 40 panelistas (74% médicos, 70% del ámbito de la...

  9. Eficacia de finasterida en el tratamiento de la hematuria asociada a la hiperplasia protática benigna

    OpenAIRE

    Palou, J.; Gausa, L.; J. Salvador; MILLÁN, F.; Segarra, J; H. Villavicencio

    2005-01-01

    La hematuria es una complicación de la hiperplasia benigna de próstata (HBP), tanto en su evolución natural como durante el seguimiento post cirugía prostática. En el estudio de Mebust et al., de 3000 pacientes sometidos a prostactectomía por Hiperplasia prostática benigna (HBP), en el 12 % la presencia de hematuria fue la causa de esta indicación quirúrgica (1). Existen escasas referencias de la acción de la finasterida ante dicho síntoma (2-7), aunque los resultados publicados hasta el mome...

  10. El proceso creativo en personas diagnosticadas de Trastorno de la Conducta Alimentaria

    OpenAIRE

    Gutiérrez Ajamil, Estibaliz

    2013-01-01

    La finalidad de este estudio es comprender las consecuencias psicológicas y emocionales que el proceso creativo provoca en personas diagnosticadas de Trastornos de la Conducta Alimentaria (TCA). Para ello, se desglosa el trabajo en dos partes: En la primera se analiza el estado de la cuestión a partir de una revisión de la literatura en la que se estudian en paralelo la situación emocional que viven las personas con TCA y las estructuras psíquicas necesarias para la elaboración del proceso cr...

  11. INTERVENCIÓN GRUPAL Y CALIDAD DE VIDA EN PERSONAS DIAGNOSTICADAS DE VIH

    OpenAIRE

    Ana Fernanda Uribe Rodríguez

    2005-01-01

    El objetivo de esta investigación es identificar las áreas de mayor y menor nivel en la calidad de vida de las personas diagnosticadas de VIH antes y después de una intervención grupal. La muestra fue de 19 hombres diagnosticados de VIH, cuya edad oscila entre 30 y 50 años. Es una investigación cuasiexperimental con diseño pre y pos prueba con grupo control y experimental. Se utilizó el Cuestionario Multidimensional de Calidad de vida para personas con VIH/sida. Durante cuatro meses se realiz...

  12. Prevalência e associações da vertigem posicional paroxística benigna em idosos

    Directory of Open Access Journals (Sweden)

    Michelle Damasceno Moreira

    2014-10-01

    Full Text Available OBJETIVO:verificar a prevalência da vertigem posicional paroxística benigna e identificar suas prováveis associações em uma população de idosos.MÉTODOS:estudo transversal realizado em idosos, submetidos à avaliação audiológica, questionário e à Manobra de Dix-Hallpilke. Aplicaram-se os testes não paramétricos: Qui-quadrado e regressão multivariada com intervalo de confiança de 95%.RESULTADOS:a amostra final foi de 494 indivíduos, com mediana de idade de 69(64,75- 74,00 anos. Observou-se a prevalência de 23,9% de vertigem posicional paroxística benigna e 51,6% de dor cervical e 37,9% de cefaléia. Houve associação estatisticamente significante entre a vertigem posicional paroxística benigna e dor cervical, gênero e cefaléia nesta população.CONCLUSÃO:conclui-se que nesta população de idosos a prevalência da vertigem posicional paroxística benigna foi de 23,9% e da dor cervical foi de 51,6% e houve associação significante entre a vertigem posicional paroxística benigna com a dor cervical e com o gênero feminino.

  13. Endovascular treatment of a basilar artery dissecting aneurysm Fasciculações benignas responsivas à gabapentina

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    Cassiano Mateus Forcelini

    2007-12-01

    Full Text Available Fasciculations are symptoms present in a broad spectrum of conditions, ranging from normal manifestations to motor neuron diseases. They also represent the main picture of benign fasciculation syndrome. We report a case of such syndrome: a 48-years-old woman complaining about fasciculations for three decades who remained with the symptoms even after the compensation of a disclosed hyperthyroidism. The introduction of gabapentin rendered control of her fasciculations. The available data in the literature about the therapeutic approaches for fasciculations are revised, as long as the rare reports of evolution from patients with "benign" fasciculations to cases of amyotrophic lateral sclerosis, underlining the importance of following the patients with fasciculations.Fasciculações são sintomas presentes em um amplo espectro de condições, desde manifestações normais até doenças do neurônio motor. Elas representam também o principal aspecto da síndrome de fasciculações benignas. Relatamos um caso desta síndrome: uma paciente de 48 anos com queixas de fasciculações por três décadas que, mesmo após a compensação de um quadro de hipertireoidismo, permaneceu com os sintomas. A introdução de gabapentina levou a controle das fasciculações. Os dados disponíveis na literatura sobre as abordagens terapêuticas para fasciculações são revisados, assim como os raros relatos de evolução de pacientes com fasciculações "benignas" para casos de esclerose lateral amiotrófica, salientando a importância do seguimento dos pacientes com fasciculações.

  14. Regulation of the malic enzyme gene malE by the transcriptional regulator MalR in Corynebacterium glutamicum.

    Science.gov (United States)

    Krause, Jens P; Polen, Tino; Youn, Jung-Won; Emer, Denise; Eikmanns, Bernhard J; Wendisch, Volker F

    2012-06-15

    Corynebacterium glutamicum is a Gram-positive nonpathogenic bacterium that is used for the biotechnological production of amino acids. Here, we investigated the transcriptional control of the malE gene encoding malic enzyme (MalE) in C. glutamicum ATCC 13032, which is known to involve the nitrogen regulator AmtR. Gel shift experiments using purified regulators RamA and RamB revealed binding of these regulators to the malE promoter. In DNA-affinity purification experiments a hitherto uncharacterized transcriptional regulator belonging to the MarR family was found to bind to malE promoter DNA and was designated as MalR. C. glutamicum cells overexpressing malR showed reduced MalE activities in LB medium or in minimal media with acetate, glucose, pyruvate or citrate. Deletion of malR positively affected MalE activities during growth in LB medium and minimal media with pyruvate, glucose or the TCA cycle dicarboxylates l-malate, succinate and fumarate. Transcriptional fusion analysis revealed elevated malE promoter activity in the malR deletion mutant during growth in pyruvate minimal medium suggesting that MalR acts as a repressor of malE. Purified MalR bound malE promoter DNA in gel shift experiments. Two MalR binding sites were identified in the malE promoter by mutational analysis. Thus, MalR contributes to the complex transcriptional control of malE which also involves RamA, RamB and AmtR. PMID:22261175

  15. The mean age of petit mal epilepsy

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    Afsarunnesa Syeda

    2016-01-01

    Full Text Available Objective: Petit mal epilepsy or absence seizures involve brief, sudden lapses of consciousness and most often occurs in people under age of 20 years. This study was done to find out the most likely significant age affected by petit mal epilepsy and whether they had higher rate of behavioral, educational, and social problems. Materials and Methods: We run tests on total 32 patients (male 16 and female 16 from newborns to 20 years of age. Results: The most affected ages were from 4 to 9 years and both genders were equally affected. They have higher rate of behavioral, educational, and social problems, and most likely recovering ages from the disease were from 15 to 20 years. Conclusion: These findings could contribute in diagnosis and treatment of Petit Mal Epilepsy, as it often misinterpreted as daydreaming or inattention.

  16. The mean age of petit mal epilepsy

    Science.gov (United States)

    Syeda, Afsarunnesa; Karim, Md. Rezaul

    2016-01-01

    Objective: Petit mal epilepsy or absence seizures involve brief, sudden lapses of consciousness and most often occurs in people under age of 20 years. This study was done to find out the most likely significant age affected by petit mal epilepsy and whether they had higher rate of behavioral, educational, and social problems. Materials and Methods: We run tests on total 32 patients (male 16 and female 16) from newborns to 20 years of age. Results: The most affected ages were from 4 to 9 years and both genders were equally affected. They have higher rate of behavioral, educational, and social problems, and most likely recovering ages from the disease were from 15 to 20 years. Conclusion: These findings could contribute in diagnosis and treatment of Petit Mal Epilepsy, as it often misinterpreted as daydreaming or inattention.

  17. Mal'tsev algebras and triality

    International Nuclear Information System (INIS)

    A concept of the Mal'tsev pair is presented. This concept is based on the generalized Maurer-Cartan equations of a local analytic Moufang loop. The triality can be seen as a fundamental property of such pairs. Based on triality, the Yamagutian is constructed. Properties of the Yamagutian are studied.

  18. Enfermedades pleurales benignas inducidas por asbesto Benign pleural diseases induced by asbestos

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    J. Boldú

    2005-01-01

    Full Text Available La exposición al asbesto es una causa importante de patología pleural y se puede producir con intensidades moderadas o ligeras dada la capacidad del asbesto de concentrarse en la pleura. Ello motiva junto a la prolongada latencia existente entre la exposición y la enfermedad, que sigamos viendo durante muchos años manifestaciones clínicas pleurales de exposición previa, a pesar del uso del asbesto cada vez más limitado en las últimas décadas. Dicha exposición puede presentarse con distintas manifestaciones tanto malignas como el mesotelioma como benignas, siendo las principales de éstas el derrame pleural benigno, las placas pleurales, la fibrosis pleural difusa y la atelectasia redonda.Exposure to asbestos is an important cause of pleural pathology and can be produced with light or moderate tendencies given the capacity of asbestos to concentrate in the pleura. Together with the prolonged latency existing between exposure and the disease, this means that for many years we will continue to see pleural clinical manifestations from past exposure, in spite of the increasingly limited use of asbestos in recent decades. This exposure can show itself in different manifestations, both malign, such as mesothelioma, and benign, principally benign pleural effusion, pleural plaques, diffuse pleural fibrosis and massive atelectasis.

  19. Biologia da nidificação de Megachile (Moureapis benigna Mitchell

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    Frederico Teixeira

    2011-11-01

    Abstract. This paper describes the biology, ecology and nest architecture of Megachile (Moureapis benigna Mitchell in trap nests (NA. The NA were installed in five forest fragments of 2.1 to 920ha, and two disturbed areas (pasture and plantation. We used bamboo canes (NB and black cardboard tubes placed on wooden boards (NC to attract nesting females. Bees occupied 17 NA (12 NB - 9 to 21mm in diameter - and 5 NC - 8 to 10mm in four forest fragments forming 26 nests (one to six nests per NB. No nest was founded in disturbed areas. There was no difference between NB and NC related to the size of formed nests (t= 0.31, p= 0.763, df= 25. The number of cells ranged from 1 to 13 per nest, being larger in NB than in NC (t= 2.26, p= 0.033, df= 25. The construction activity occurred during the rainy season (October to March, with no correlation to climate parameters. Emergence (1 to 12 per nest was correlated with humidity (t= 3.013, p= 0.006. Time to adult emergence varied from 1 to 141 days. The sex ratio was 1.8:1 male/female, differing from 1:1 (Χ2= 9.39, p<0.002. The parasites were Coelioxys otomita Cresson and two other species of Coelioxys. The species demonstrates plasticity in nesting substrate, and preference for cavities with diameters larger than 9mm. There is a possible dependence of the species to forest environments, since the higher occurrence of nesting was in forest areas in advanced stages of regeneration.

  20. EFECTO DE Tropaeolum tuberosum FRENTE A LA HIPERPLASIA PROSTÁTICA BENIGNA INDUCIDA EN RATAS HOLTZMAN

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    Gioliana Aire-Artezano

    2013-01-01

    Full Text Available Objetivo: Evaluar el efecto de Tropaeolum tuberosum(mashua frente a la Hiperplasia Prostática Benigna (HPB y compararlo con finasterida. Métodos: Estudio experimental completo. Se emplearon 30 ratas Holtzman macho de 12 semanas de edad, aleatorizadas y divididas en seis gru- pos: grupo blanco; grupo testosterona; grupo finasterida (0.33mg/kg/rata; y tres grupos dosis, dosis 1 (300mg/kg/rata, dosis 2 (500mg/kg/rata y dosis 3 (800mg/kg/rata tratados con Tropaeolum tuberosum. Se realizó una medición basal del volumen prostático mediante una ecografía transabdominal. La inducción de HPB se realizó con enantato de testosterona (0,083mg/Kg/rata en los grupos dosis, finasterida y testosterona, el día uno y siete. Paralelamente, se administró liofilizado de Tropaeolum tuberosum y finasterida durante 21 días. Para el diagnóstico, se realiza- ron estudios por imágenes, anatomopatológicos e histopatológicos. Resultados: El estudio por imágenes, en relación al incremento del volumen prostático,no arrojó diferencia significativa entre dosis 2 y finasterida; mientras que en relación con la ecogenicidad, dosis 3 presentó similitud cualitativa al finasterida. En el estudio anatomopatológico, no hubo diferencia significativa entre el grupo dosis 3 y el grupo finasterida. Histo- patológicamente, dosis 3 se asemejó cuantitativamente al finasterida. Conclusiones: Se evidenció disminución de la HPB histológicamente y en el estudio por imágenes; sin embargo, ninguna de las dosis mostró efecto superior al finasterida.

  1. Malária falciparum resistente à cloroquina e ao Fansidar R tratada com minociclina Minocycline treatment of chloroquine-and Fansidar R-resistant falciparum malarial

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    José J. Ferraroni

    1983-08-01

    Full Text Available Em abril de 1978 uma infecção malárica causada por Plasinodium falciparum foi diagnosticada em um paciente adulto do sexo masculino, nativo da Amazônia brasileira. O parasito foi resistente in vitro à cloroquina e in vivo à associação pirimetamina + sulfadoxina (FansidarR. O paciente foi tratado com minociclina (MinomaxR; contudo, sua resposta imune ao parasito pode ter tido um importante papel na eficácia do tratamento com a minociclina.In April 1978, a Plasmodium falciparum infection was diagnosed in an adult male in Brazilian Amazonia. The parasite was resistant in vitro to chloroquine and resistent in vivo to pyrimethamine-sulfadoxine (FansidarR. The patient was successfully treated with minocycline (MinomaxR; however, his immune response to the parasite may have played an important role in the efficacy of the minocycline treatment.

  2. Tuberculosis laríngea diagnosticada en una escolar Laryngeal tuberculosis diagnosed in a school girl

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    Marcela González L

    2006-09-01

    Full Text Available La tuberculosis (TBC es en la actualidad una endemia a nivel mundial. La tuberculosis extrapulmonar, menos frecuente que la forma pulmonar constituye un desafío diagnóstico. La forma laríngea representa menos del 1% de las tuberculosis extrapulmonares. En esta publicación, presentamos un caso de tuberculosis laríngea diagnosticada en una escolar de nuestro servicio de pediatría hospital Dr. Gustavo Fricke, cuyos síntomas cardinales fueron disfonía y tos presentes durante 6 meses previo al diagnóstico. Al momento de ingreso al servicio se había agregado compromiso del estado general, odinofagia estridor y dificultad respiratoria. Al examen físico destacaba la presencia de masa cervical. El diagnóstico se realizó mediante laringoscopia directa que evidenció nódulo en cuerda vocal derecha cuya biopsia reveló presencia de proceso inflamatorio crónico granulomatoso compatible con TBC. Las baciloscopías y cultivo de Koch de expectoración, realizados al momento del ingreso, resultaron positivos. Cabe destacar el retraso diagnóstico del caso, debido a que nunca se planteó realizar laringoscopia durante el estudio ambulatorio, pese a la presencia de disfonía y tos persistenteTuberculosis is at the present time a worldwide endemic disease. Extrapulmonary tuberculosis is less frequent than the pulmonary form and its diagnosis represents a challenge. Laryngeal tuberculosis accounts for less than 1% of extrapulmonary tuberculosis. In this report, we present a case of laryngeal tuberculosis diagnosed in a 12 years old girl at the pediatric department of a general hospital. The patient had a six months history of hoarseness and persistent cough. At the time she was admitted at the hospital she complainted about stridor, odynophagia, weakness and respiratory distress. A cervical mass was the main finding at her physical exam. A laryngeal nodule was shown after practicing a direct laryngoscopy. The biopsy of this lesion revealed presence of

  3. Epilepsias generalizadas idiopáticas diagnosticadas incorretamente como epilepsias parciais

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    Mory Susana B.

    2002-01-01

    Full Text Available A epilepsia generalizada idiopática (EGI frequentemente não é diagnosticada corretamente em adultos, com sérias consequências para os pacientes. O objetivo deste estudo foi avaliar os fatores mais frequentemente associados a dificuldades no diagnóstico diferencial entre epilepsias parciais e generalizadas em adultos. Avaliamos 41 pacientes com diagnostico de crises parciais complexas com elementos de anamnese e EEG indicando um possível diagnóstico diferencial. Foi possível a mudança do diagnóstico de epilepsia parcial para EGI em 25 pacientes: 22 (88% com EMJ; um com ausência juvenil, um com síndrome de ausências com mioclonias periorais e um com ausência com mioclonias palpebrais. Mioclonias, uma das características da EMJ e outras formas de EGI, geralmente não eram espontaneamente relatadas pelos pacientes. Abalos mioclônicos unilaterais eram confundidos com crises parciais motoras. Ausências breves e pouco frequentes e anormalidades focais no EEG contribuíram para o não reconhecimento de EGI. Todos os 25 pacientes apresentavam crises sem controle adequado antes da revisão diagnóstica. Após o diagnóstico correto e mudança para monoterapia com acido valpróico ou valproato de sódio, 19 (76% ficaram livre de crises e seis (24% dos 25 pacientes apresentaram melhora significativa. A associação de lamotrigina em três destes pacientes propiciou redução significativa da frequência de crises. Em conclusão, anamnese detalhada e questionamento direcionado para determinar a presença de mioclonias e crises tipo ausência e a sua interpretação no contexto clínico são fundamentais para o diagnóstico correto das EGI em adultos.

  4. El estigma en mujeres diagnosticadas con VPH, displasia y cáncer cervicouterino en Hermosillo, Sonora

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    María del Carmen Arellano Gálvez

    2013-01-01

    Full Text Available Nuestro objetivo es indagar sobre las vivencias y percepciones de un grupo de mujeres de una ciudad al norte de México que han sido diagnosticadas con el virus del papiloma humano, displasias y cáncer cervicouterino. Realizamos treinta y cuatro entrevistas cualitativas; se identificó que las mujeres viven la experiencia de diagnóstico como un estigma, pues alude a su sexualidad, fidelidad y creencias religiosas, por lo que ponen en marcha estrategias protectoras para evitar ser estigmatizadas.

  5. Mal/SRF is dispensable for cell proliferation in Drosophila.

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    Barry J Thompson

    Full Text Available The Mal/SRF transcription factor is regulated by the level of G-actin in cells and has important roles in cell migration and other actin-dependent processes in Drosophila. A recent report suggests that Mal/SRF and an upstream regulator, Pico, are required for cell proliferation and tissue growth in Drosophila. I find otherwise. Mutation of Mal or SRF does not affect cell proliferation in the fly wing. Furthermore, I cannot reproduce the reported effects of Pico RNAi or Pico overexpression on body size. Nevertheless, I can confirm that overexpression of Pico or Mal causes tissue overgrowth specifically in the fly wing--where SRF is most highly expressed. My results indicate that Mal/SRF can promote tissue growth when abnormally active, but is not normally required for tissue growth during development.

  6. Repolarización precoz: de benigna a muerte súbita

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    Guillermo Trout

    2013-11-01

    Full Text Available Title: Early repolarization: from benign to sudden death La repolarización precoz es un hallazgo frecuente caracterizado por elevación del segmento ST, empastamiento al final del QRS en 2 o más derivadas electrocardiográficas contiguas. Durante años fue considerada benigna, pero actualmente observaciones de casos, estudios clínicos y electrofisiológicos sugieren un rol crítico en la patogénesis de la fibrilación ventricular idiopática. Estudios poblacionales establecieron asociación entre esta patente y el riesgo de muerte por eventos arrítmicos. La muerte súbita cardiaca es un problema de salud pública, anualmente causa alrededor de 350.000 muertes en Estados Unidos. Muchos casos están asociados a arritmias ventriculares, de los cuales 6-14% son en individuos sin cardiopatía estructural y está determinada por anormalidades genéticas que afectan los canales iónicos o idiopáticos como el síndrome de repolarización precoz y la fibrilación ventricular idiopática que generan el 10% de dichas muertes. La revisión aborda la fisiopatología de la RP, con el fin de comprender los mecanismos por los cuales es asociada a arritmias malignas. Además, para diferenciar este patrón de otros que también generan elevación del ST y dilucidar el enfoque y recomendaciones actuales para el diagnóstico y manejo. (DUAZARY 2013 No. 1, 41 - 50AbstractEarly repolarization is a common finding characterized by ST segment elevation, QRS slurring end in 2 or more contiguous electrocardiographic derivative. For years he was considered benign, but at present observations of cases, clinical and electrophysiological studies suggest a critical role in the pathogenesis of idiopathic ventricular fibrillation. Population studies established association between this patent and risk of death from arrhythmic events. Sudden cardiac death is a public health problem, annually causes about 350,000 deaths in America. Many cases are associated with ventricular

  7. Enfermidades diagnosticadas em bezerros na região sul do Rio Grande do Sul

    Directory of Open Access Journals (Sweden)

    Nathalia D. Assis-Brasil

    2013-04-01

    Full Text Available O objetivo deste estudo foi relatar a frequência das enfermidades que ocorrem em bovinos até um ano de idade na área de influência do Laboratório Regional de Diagnóstico (LRD da Faculdade de Veterinária da Universidade Federal de Pelotas (UFPel estabelecendo os principais fatores epidemiológicos associados à ocorrência dessas enfermidades. Foram revisados os protocolos de necropsias realizadas e de materiais de bovinos até um ano de idade, encaminhados ao LRD/UFPel entre 2000 e 2011. Em 35,6% dos casos, os bezerros eram de raças leiteiras e em 33,98% eram animais de raças de corte, 18,3% dos bezerros não tinham raça definida e em 12,1% dos casos não constava a raça no protocolo de necropsia. Os sistemas mais afetados foram o sistema nervoso central (22,7%, o digestivo (18,6% e o respiratório (16,8%. Os diagnósticos foram divididos por faixa etária sendo que 88 bezerros tinham 1-90 dias de idade; 42 casos corresponderam a animais de 4-6 meses; 32 casos corresponderam a bezerros com 7-9 meses e 44 eram bezerros com 10-12 meses de idade. As enfermidades mais frequentemente diagnosticadas nos bezerros de 1-90 dias foram pneumonias, malformações e encefalites/meningoencefalites com 19,3%, 15,9% e 11,3% dos casos, respectivamente. Nos bezerros com 4-6 meses de idade, as pneumonias ocorreram em 16,5% dos casos e o carbúnculo sintomático e as enterites representaram 7,1% dos diagnósticos cada. Nos bezerros de 7-9 meses, as enfermidades mais frequentes foram pneumonias e tétano com 9,3% dos casos e babesiose e parasitoses gastrintestinais com 6,2% cada. Nos bezerros de 10-12 meses a infecção por BoHV-5 representou 13,6% dos casos e as pneumonias, a raiva e as parasitoses foram observadas em 9,% dos casos cada. Com base nos resultados deste trabalho pode-se concluir que as doenças infecciosas relacionadas ao sistema respiratório foram importantes causas de mortalidade em bezerros de todas as faixas etárias na área de influ

  8. Walter Benjamin , leitor das Flores do mal

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    Dolf Oehler

    2014-10-01

    Full Text Available O texto conta a história da leitura de Baudelaire por Benjamin. Desde as traduções mal recebidas ao projeto das Passagens. Leitor fraterno, Benjamin vive as mesmas condições do poeta – sem domicílio, sem biblioteca, sem posição social. Assim consegue apreender profundamente a poesia baudelairiana.Abstract: The text tells the story of the work of Benjamin about Baudelaire. Since the first translations to the Passagenwerk Project. As a fraternal reader, Benjamin lives the same conditions of the poet – without a home, without a library, without a social position. These similarities make possible to him to understand profoundly Baudelaire’s poetry.Keywords: Benjamin; Baudelaire; poetry; city. Dolf Oehler é professor Emérito de Literatura Comparada da Universidade de Bonn

  9. Savoir gérer le mal

    Directory of Open Access Journals (Sweden)

    Michel Maffesoli

    2015-09-01

    Full Text Available Le sens commun, conservatoire immémorial de la sagesse humaine « sait », de savoir incorporé, que le mal, l’ombre, la mort, la douleur sont des caractéristiques essentielles de l’existence en son entièreté. Dès lors les créatures quelles qu’elles soient, sont des manifestations de la vie et, dès lors, méritent une attitude « compassionnelle », fraternelle, parce qu’ensemble elles constituent le flux vital. C’est ainsi que l’on peut comprendre l’utilité sociale de ces divers « mondes intermédiaires » que sont les croyances, religieuses ou philosophiques, au « double », au « daimon », aux esprits et autres figures tutélaires ou effrayantes. Elles aident à vivre, au jour le jour, la souffrance en la communalisant.

  10. Evaluación de los efectos del tratamiento con tadalafilo sobre las funciones cerebrales, neurológicas y bioquímicas en pacientes con hiperplasia benigna de próstata y disfunción eréctil

    OpenAIRE

    Ordoño Domínguez, Felipe

    2015-01-01

    EVALUACION DE LOS EFECTOS DEL TRATAMIENTO CON TADALAFILO SOBRE LAS FUNCIONES CEREBRALES, NEUROLOGICAS Y BIOQUIMICAS EN PACIENTES CON HBP Y DISFUNCION ERECTIL. La hiperplasia prostática benigna (HBP) es una de las enfermedades benignas más comunes en el hombre y puede derivar en una hipertrofia benigna de la próstata, en una obstrucción benigna de la próstata y/o en síntomas del tracto urinario inferior (STUI). La hiperplasia benigna de próstata suele estar asociada habitualmente con disfu...

  11. Potencial terapêutico de extratos de plantas medicinais em hiperplasia benigna da próstata

    OpenAIRE

    Silva, Virgínia Eduarda Monteiro da

    2015-01-01

    Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas As doenças da próstata, tais como, a prostatite, a hiperplasia benigna da próstata e o cancro da próstata, apresentam grande relevância clínica pela alta frequência com que ocorrem no quotidiano e pelas consequências que provocam. A Fitoterapia é uma terapêutica não convencional que tem vindo, ao longo das últimas décad...

  12. Comparação entre fragmentos obtidos com agulhas de calibres 14 e 12 em "core biopsy" estereotáxica de lesões mamárias impalpáveis: diferenças entre o tamanho dos fragmentos e freqüência dos tipos de lesões diagnosticadas

    Directory of Open Access Journals (Sweden)

    Abreu-e-Lima Maria do Carmo

    2001-01-01

    Full Text Available Com o objetivo de avaliar o desempenho das agulhas de calibres 14 e 12 na obtenção de "core biopsies" da mama sob controle estereotáxico, os autores compararam biópsias de lesões mamárias impalpáveis obtidas com agulhas desses calibres quanto ao tamanho dos fragmentos e freqüência dos tipos de lesões diagnosticadas. De um total de 1.009 biópsias, os autores analisaram 900 obtidas por agulhas 14 e 109 obtidas por agulhas 12, para análise da freqüência das lesões. Os tamanhos dos fragmentos foram analisados nos 700 primeiros casos para os espécimes obtidos por agulhas 14. A utilização de agulhas 12 resultou em maior tamanho dos fragmentos (p < 0,001, ausência de material insatisfatório, redução na proporção das lesões benignas não-neoplásicas (p = 0,03 e aumento na freqüência de carcinomas (p < 0,001, tanto in situ como invasivos. Tais achados podem refletir aumento da acurácia do diagnóstico, em virtude da maior quantidade de material e/ou melhor seleção radiológica das biópsias obtidas por agulhas 12, pela utilização coincidente da mamografia digital em campo limitado (estereotaxia digital.

  13. Estudio del factor de crecimiento del endotelio vascular (VEGF) y del factor de crecimiento fibroblástico básico (bFGF) en la patología benigna y maligna de la próstata.

    OpenAIRE

    Rodrigo Guanter, Vicente

    2005-01-01

    RESUMEN INTRODUCCION El PSA es el mejor marcador tumoral disponible y utilizado en la actualidad para el diagnóstico y seguimiento del tratamiento del cáncer de próstata. La discriminación entre la patología benigna y maligna de la próstata, en especial entre la hiperplasia benigna de próstata y el cáncer de próstata es crucial. Desafortunadamente, el PSA no siempre puede distinguir eficientemente entre enfermedad maligna y benigna de la próstata, especialmente en el intervalo de ...

  14. Arendt, Eichmann y la banalidad del mal

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    López, Marina

    2010-04-01

    Full Text Available In this text I describe the characteristics that Hannah Arendt attributes to the SS agents through the figure of Eichmann, during the German Nazi regime of the 20th century. According to this characterization, I intend to show, on the one hand, that there is not a break in Arendt’s thought on evil, i.e. from The Origins of Totalitarianism to Eichmann in Jerusalem: a report on the banality of evil, but a continuous line of thought. And, on the other hand, I try to follow the clues that Arendt gives concerning the “banality” that defines the behavior of individuals such as Eichmann. Both premises will permit me to point out what, in my understanding, the banalization of humanity implies, not only in the context of the Jewish Holocaust, but in each of the societies in which the elimination of spontaneity is a reality.

    En el texto se describen las características que Hannah Arendt, a través de la figura de Eichmann, atribuye a los agentes SS durante el régimen nazi alemán de mediados del siglo XX. Con la caracterización se persigue mostrar, en principio, que no hay una ruptura en el pensamiento de Hannah Arendt respecto a su manera de considerar el mal, desde Los orígenes del Totalitarismo hasta Eichmann en Jerusalén, un estudio sobre la banalidad del mal, sino una continuidad y, por otra parte, seguir las pistas que Arendt propone en torno a la “banalidad” que define el comportamiento de individuos como Eichmann. Ambas premisas nos permitirán poner de relieve lo que, a nuestro parecer, implica la banalización de la humanidad no sólo en el contexto del Holocausto judío, sino en cada una de las sociedades en las que la eliminación de la espontaneidad es una realidad.

  15. Effects of sodium mal-distribution on AHX thermal characteristics

    Energy Technology Data Exchange (ETDEWEB)

    Yeom, Sujin; Hong, Jonggan; Eoh, Jae-Hyuk; Jeong, Ji-Young [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-10-15

    The uniform distribution of a refrigerant is very important to the heat transfer performance of heat exchangers. In particular, for a sodium-to-air heat exchanger (AHX), transferring heat from high temperature liquid metal to air, a mal-distribution of the refrigerant can cause degradation of heat transfer performance or even failure of system by unexpected sodium solidification in flow paths. However, there are little quantitative studies about the effect of maldistribution on thermal characteristics with liquid metal as a coolant. This paper discusses the effects of mal-distribution on heat transfer performance and cold-spot temperature of liquid sodium coolant at the branched tube outlet in AHX unit. The technical issues, which need to be verified for the robust AHX design regarding uniform flow distribution inside heat transfer sodium tubes, are tentatively proposed as well. In this paper, the effects of sodium mal-distribution on heat removal rate and sodium outlet temperature at the branched tubes of the AHX were quantitatively investigated and the following features were tentatively obtained - The effect of mal-distribution on the total heat removal rate is not significant. - The outlet temperature difference between low and high flow rate tubes (T{sub NA,out}) increases as the degree of mal-distribution increases. - In some conditions, the outlet temperature of branched tube reaches the sodium solidification temperature when the degree of mal-distribution increases. An important point is that the sodium mal-distribution would finally result in a system failure by unexpected sodium solidification. Therefore, the studies about the improvement of coolant distribution at the AHX unit need to be conducted by carefully considering characteristics of liquid metal coolant as a future work.

  16. Lipomatose simétrica benigna e pelagra, associadas ao alcoolismo Benign symmetrical lipomatosis and pellagra associated with alcoholism

    Directory of Open Access Journals (Sweden)

    Fernanda de Marca Filgueiras

    2011-12-01

    Full Text Available Paciente masculino, 42 anos, etilista crônico, apresentando quadro de tumorações em região cervical e ao redor dos ombros, lesões eritemato-violáceas, descamativas e algumas lesões bolhosas, nas áreas fotoexpostas dos membros superiores e inferiores. Baseado no quadro clínico e nos exames complementares, foi estabelecido o diagnóstico de pelagra associada à lipomatose simétrica benigna, sendo ambos os quadros justificados pelo etilismo crônico. Tratado com reposição de complexo B intravenoso e orientado quanto à importância da abstinência alcoólica, apresentou remissão completa do quadro cutâneo, porém sem alteração da lipomatose.A 42-year-old male patient, alcoholic, presented showing signs of tumors in the neck and around the shoulders, scaly, erythematous-violaceous lesions and some bullous lesions in sun-exposed areas of upper and lower limbs. Based on clinical features, laboratory tests and imaging studies we have established the diagnosis of pellagra associated with benign symmetrical lipomatosis, both justified by chronic alcoholism. Treated with intravenous B-complex and oriented about the importance of alcohol withdrawal, the patient showed complete remission of skin lesions, but with no change in the lipomatosis.

  17. Malária grave importada: relato de caso Severe imported malaria: case report

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    Alessandra Alves

    2007-06-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A malária ainda representa um problema de saúde global. A forma grave da doença é causada principalmente por P. falciparum e pode cursar com complicações cerebrais, renais, pulmonares, hematológicas, circulatórias e hepáticas. O objetivo deste estudo foi relatar um caso de paciente portador de malária grave importada. RELATO DO CASO: Paciente do sexo masculino, 30 anos, pardo, filipino, marinheiro, proveniente de embarcação vinda da Nigéria, com história de dor abdominal no hipocôndrio direito, icterícia, febre e rebaixamento do nível de consciência. Os exames laboratoriais de admissão mostraram hiperbilirrubinemia de 50 mg/dL, acidose metabólica grave, trombocitopenia, creatinina de 5,6 mg/dL, leucocitose com desvio até metamielócitos. O escore APACHE II foi de 37, com risco de óbito de 88%. Durante a internação foi diagnosticada malária por P. falciparum pelo teste de gota espessa. Mesmo com tratamento antimalárico adequado, o paciente evoluiu com insuficiência renal aguda necessitando de hemodiálise e síndrome de angústia respiratória aguda (SARA, necessitando de ventilação mecânica (VM, choque refratário tratado com aminas vasoativas, além de quadro hematológico, configurando um caso grave de disfunção de múltiplos de órgãos. Ainda apresentou pneumonia associada à VM e sepse relacionada ao uso de cateteres. Após a alta hospitalar, o paciente não apresentou seqüelas cerebral, pulmonar ou renal. CONCLUSÕES: Dos critérios definidores de malária grave descritos na literatura, o paciente preenchia: insuficiência renal aguda, síndrome da angústia respiratória aguda (SARA, acidose metabólica, alteração do nível de consciência, hemoglobinúria macroscópica, hiperparasitemia e hiperbilirrubinemia, que se relaciona a uma mortalidade maior que 10%, na dependência do tratamento precoce e dos recursos disponíveis. A malária grave exige diagnóstico e tratamento

  18. Literatura y competencia comunicativa: ¿matrimonio mal avenido?

    OpenAIRE

    Ximena Troncoso Araos

    2014-01-01

    Este artículo aborda la relación problemática entre enseñanza de la literatura y enfoque comunicacional, específicamente, entre aprender literatura y desarrollar la competencia comunicativa. A partir de esta tensión diagnosticada, surgen las preguntas: ¿es plausible enseñar literatura desarrollando a la vez competencias comunicativas?, ¿es compatible la literatura con un enfoque comunicativo? Estas interrogantes consideran una premisa: entender la literatura como dominio con características d...

  19. Resonancia Magnética Nuclear de cráneo en primeras familias cubanas diagnosticadas con ataxia de Friedreich

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    Tania Cruz Mariño

    2011-01-01

    Full Text Available La ataxia de Friedreich se caracteriza por edad de comienzo antes de los 25 años, ataxia progresiva, disartria, ausencia de reflejos tendinosos profundos y alteraciones en el sentido de vibración. La presente investigación se realizó con el objetivo de describir las características imagenológicas de las estructuras del sistema nervioso central en las primeras familias cubanas diagnosticadas con la enfermedad. Mediante un equipo de 0.23 Teslas -PANORAMA-, Phylips Medical Systems, con una bobina estándar de cráneo, se obtuvieron cortes axiales de 5mm de grosor usando secuencias de FLAIR, T1 y T2, así como cortes sagitales en T1 y T2 en tres individuos con diagnóstico molecular confirmatorio de ataxia de Friedreich y seis controles saludables pareados mediante edad y sexo. Las estructuras con mayor afectación morfológica son la médula espinal cervical, el cerebelo y la protuberancia, lo cual provee evidencia in vivo de que la enfermedad conduce a atrofia de dichas estructuras.

  20. Baitul Mal and Legal Constraint: Public Wealth Management in Malaysian Context

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    Bayu Taufiq Possumah

    2012-11-01

    Full Text Available Baitul-Mal is normally known as a charitable institution. This point is true because presently Baitul-Mal role is more prominent in terms of providing assistance and charitable contributions and donations to the public. In essence, the original scope of Baitul-Mal covers a wider role compared to the current concept of Baitul-Mal. If we view from the context of Baitul-Mal at the early Islam, it turns out that Baitul-Mal is the only and center for the treasury of the state, but in the Malaysian context, scope and functions of Baitul-Mal are limited by the legal constraint. This paper is aimed to analyze the legal constraint and propose some procedures to empower the function and resource mobilization of Baitul-Mal. This paper will also expose that to improve the functions it can be done by using Islamic financial instruments.

  1. Investigation of the malE promoter and MalR, a positive regulator of the maltose regulon, for an improved expression system in Sulfolobus acidocaldarius.

    Science.gov (United States)

    Wagner, Michaela; Wagner, Alexander; Ma, Xiaoqing; Kort, Julia Christin; Ghosh, Abhrajyoti; Rauch, Bernadette; Siebers, Bettina; Albers, Sonja-Verena

    2014-02-01

    In this study, the regulator MalR (Saci_1161) of the TrmB family from Sulfolobus acidocaldarius was identified and was shown to be involved in transcriptional control of the maltose regulon (Saci_1660 to Saci_1666), including the ABC transporter (malEFGK), α-amylase (amyA), and α-glycosidase (malA). The ΔmalR deletion mutant exhibited a significantly decreased growth rate on maltose and dextrin but not on sucrose. The expression of the genes organized in the maltose regulon was induced only in the presence of MalR and maltose in the growth medium, indicating that MalR, in contrast to its TrmB and TrmB-like homologues, is an activator of the maltose gene cluster. Electrophoretic mobility shift assays revealed that the binding of MalR to malE was independent of sugars. Here we report the identification of the archaeal maltose regulator protein MalR, which acts as an activator and controls the expression of genes involved in maltose transport and metabolic conversion in S. acidocaldarius, and its use for improvement of the S. acidocaldarius expression system under the control of an optimized maltose binding protein (malE) promoter by promoter mutagenesis.

  2. MAL-PDT for difficult to treat nonmelanoma skin cancer.

    Science.gov (United States)

    Stebbins, William G; Hanke, C William

    2011-01-01

    With an incidence of over 3.5 million nonmelanoma skin cancers (NMSCs) per year in the United States, there is an increasing need for effective, cost-effective treatments for NMSC. When surgical excision is impractical or not feasible, methyl aminolevulinate photodynamic therapy (MAL-PDT) has demonstrated consistently high long-term cure rates ranging from 70-90%, with superior cosmetic outcomes compared with other treatment modalities. With the exception of invasive squamous cell carcinoma, MAL-PDT has been successful in treating all types of NMSC, especially in patients with multiple comorbidities, field cancerization, and lesions in cosmetically sensitive locations. Herein, a step-by-step description of the procedure for MAL-PDT is provided, followed by a review of outcomes from large clinical trials performed over the past 15 years for each variant of NMSC. After reading this review, clinicians should have a thorough understanding of the benefits and limits of MAL-PDT, and should be able to add this valuable procedure to their armamentarium of therapies for NMSC.

  3. Histerectomía laparoscópica ambulatoria en el manejo de patología benigna ginecológica: una revisión

    Directory of Open Access Journals (Sweden)

    Javier Castro Solís

    2014-03-01

    Full Text Available Title: Outpatient laparoscopic hysterectomy for benign gynecologic disease management: an overviewObjetivo. Revisar la literatura disponible sobre la histerectomía total laparoscópica ambulatoria en el manejo de patología benigna uterina. Materiales y métodos: se realizó una búsqueda en varias bases de datos incluyendo Ovid, Medline; Md Consult, Pub Med y Scielo con las palabras clave histerectomía, total, laparoscópica, ambulatoria, benigna. La búsqueda se limitó a los últimos 24 años. Resultados: inicialmente se encontraron 62 referencias, de las cuales se seleccionaron los 41 artículos más relevantes para los objetivos de la revisión. Conclusiones: la histerectomía total laparoscópica es una técnica segura en el tratamiento de patología benigna ginecológica, el manejo ambulatorio posquirúrgico de pacientes seleccionadas sometidas a esta cirugía, no incrementa el riesgo de complicaciones y puede disminuir los costos hospitalarios. (DUAZARY 2013 No. 2, 136 - 140.AbstractObjective. Reviewing the available literatura about outpatient total laparoscopic hysterectomy for benign gynecologic disease management. Materials and methods. A search was conducted in several databases including Ovid, Medline, Md Consult, Pubmed and Scielo, with the keywords outpatient, total, laparoscopic, hysterectomy, benign. The search was limited to the last 24 years. Results. Initially found 62 references of which 42 articles were selected most relevant to the objectives of the review. Conclusions. Outpatient total laparoscopic hysterectomy is a safe procedure in the treatment of benign gynecological disease, postoperative outpatient management of selected patients undergoing this surgery does not increase the risk of complications and may decrease hospital costs.Keywords: hysterectomy; total; laparoscopic; ambulatory care.

  4. ACTITUDES DE LAS MUJERES DIAGNOSTICADAS DE CÁNCER DE MAMA FRENTE A LATOMA DE DECISIONES COMPARTIDA

    Directory of Open Access Journals (Sweden)

    Roberto Martín-Fernández

    2013-01-01

    Full Text Available Fundamentos: La mayor autonomía y el protagonismo de las mujeres con cáncer de mama en las decisiones sobre su salud son aspectos recientes en su asistencia sanitaria. El objetivo del trabajo es identificar y caracterizar los elementos que influyen en la toma de decisiones terapéuticas de las mujeres. Métodos: Metodología cualitativa de tipo fenomenológico. Muestreo teórico intencionado que incluyó a 70 mujeres diagnosticadas de cáncer de mama. Se realizaron 45 entrevistas y 3 grupos focales entre octubre de 2009 y julio de 2010 en 15 Comunidades Autónomas españolas. Análisis basado en los principios de la grounded theory con el apoyo del programa Atlas.ti v6.1. Resultados: Las pacientes se muestran proclives a tomar un papel activo o pasivo en la toma de decisiones dependiendo de la edad, la información disponible, su autovaloración como agente capaz de decidir y la importancia relativa al aspecto estético.Amedida que avanza la enfermedad se puede producir un cambio en la posición de las mujeres, desde una postura inicial pasiva a una posición más activa. La actitud de los profesionales sanitarios frente a la toma de decisiones compartida y la información que ofrecen influye en la participación de las pacientes mientras que la familia juega un papel fundamental como apoyo o refuerzo en sus decisiones. Conclusiones: La postura ante la toma de decisiones de las mujeres con cáncer de mama es muy variable, cobrando especial importancia la situación emocional, nivel de información disponible y la influencia del entorno.

  5. Cancer de mama, patologías mamarias benignas, ingesta alimentaria, estado nutricional, factores de riesgo y tiempo de lactancia materna

    OpenAIRE

    Casado, Micaela

    2014-01-01

    Una correcta alimentación antes, durante y después de la enfermedad es esencial para mantener un adecuado estado nutricional. Objetivo: Evaluar el estado nutricional, la ingesta alimentaria, el tiempo dedicado a amamantar a sus hijos y los factores de riesgo de las mujeres con cáncer de mama y patologías mamarias benignas, en un Hospital Público de la Ciudad de Mar del Plata durante el año 2014. Materiales y métodos: El estudio seleccionado es de tipo descriptivo y de caráct...

  6. The N Terminus of the Escherichia coli Transcription Activator MalT Is the Domain of Interaction with MalY

    OpenAIRE

    Schlegel, Anja; Danot, Olivier; Richet, Evelyne; Ferenci, Thomas; Boos, Winfried

    2002-01-01

    The maltose system of Escherichia coli consists of a number of genes encoding proteins involved in the uptake and metabolism of maltose and maltodextrins. The system is positively regulated by MalT, its transcriptional activator. MalT activity is controlled by two regulatory circuits: a positive one with maltotriose as effector and a negative one involving several proteins. MalK, the ATP-hydrolyzing subunit of the cognate ABC transporter, MalY, an enzyme with the activity of a cystathionase, ...

  7. The core and conserved role of MAL is homeostatic regulation of actin levels.

    Science.gov (United States)

    Salvany, Lara; Muller, Julius; Guccione, Ernesto; Rørth, Pernille

    2014-05-15

    The transcription cofactor MAL is regulated by free actin levels and thus by actin dynamics. MAL, together with its DNA-binding partner, SRF, is required for invasive cell migration and in experimental metastasis. Although MAL/SRF has many targets, we provide genetic evidence in both Drosophila and human cellular models that actin is the key target that must be regulated by MAL/SRF for invasive cell migration. By regulating MAL/SRF activity, actin protein feeds back on production of actin mRNA to ensure sufficient supply of actin. This constitutes a dedicated homeostatic feedback system that provides a foundation for cellular actin dynamics.

  8. Quedas em idosos com Vertigem Posicional Paroxística Benigna Elderly falls associated with benign paroxysmal positional vertigo

    Directory of Open Access Journals (Sweden)

    Fernando Freitas Ganança

    2010-02-01

    Full Text Available Vertigem Posicional Paroxística Benigna (VPPB pode causar quedas, principalmente em pacientes idosos. OBJETIVO: Verificar se o número de quedas em idosos com VPPB diminui após a realização de manobras de reposicionamento de partículas (MRP. MATERIAL E MÉTODO: Estudo retrospectivo em que foram incluídos idosos com VPPB que tenham apresentado queda no último ano. Todos os pacientes submeteram-se à MRP de acordo com o canal semicircular (CSC acometido. Após a abolição da vertigem e do nistagmo de posicionamento, os pacientes foram acompanhados ao longo de 12 meses e investigados em relação ao número de quedas neste período. Para comparar o número de quedas antes e após as MRP utilizou-se avaliação estatística por meio do teste de Wilcoxon. RESULTADOS: Foram incluídos 121 pacientes. Cento e um pacientes apresentaram acometimento do CSC posterior, 16 do lateral e quatro do anterior. Verificou-se redução do número de quedas após as MRP, com diferença estatisticamente significante na amostra geral (pBenign Paroxysmal Positional Vertigo (BPPV can cause falls, especially in the elderly. AIM: to study whether or not elderly patients with BPPV have a reduction on their falls after the particle repositioning maneuver (PRM. MATERIALS AND METHODS: retrospective study including elderly with BPPV who had fall(s during the last year. All patients were submitted to the PRM according to the affected semicircular canal (SCC. After the abolition of positioning vertigo and nystagmus, the patients were submitted to a 12 month follow-up and were investigated about the number of fall(s. Wilcoxon's test was performed to compare the number of fall(s before and after 12 months of the PRM. RESULTS: One hundred and twenty one patients were included in the study. One hundred and one patients presented involvement of the posterior SCC, 16 of the lateral and four of the anterior. We noticed a reduction on the number of falls, with statistically

  9. Evaluación clínica neuroandrológica de la disfunción eréctil en la cirugía prostática benigna

    OpenAIRE

    Wong Arocha, Haydee Inocenta

    2015-01-01

    La esperanza de vida ha aumentado en las últimas décadas de forma extraordinaria en la sociedad, lo que condiciona que enfermedades como la hiperplasia prostática benigna aumenten de forma inexorable. Se realizó un estudio descriptivo, prospectivo de pacientes intervenidos quirúrgicamente de hiperplasia prostática benigna en el hospital “Joaquín Albarrán Domínguez” en La Habana, durante el período comprendido desde el 2001 hasta el 2010. Fueron seleccionados 292 pacientes sexualmente activos,...

  10. Epilepsia occipital benigna da infância de início precoce (tipo Panayiotopoulos: aspectos clínicos e eletrencefalográficos evolutivos em 14 crianças Early-onset benign childhood occipital epilepsy (Panayiotopoulos type: clinical and electroencephalographic features in 14 children

    Directory of Open Access Journals (Sweden)

    Lineu Correa Fonseca

    2005-06-01

    Full Text Available Foram estudadas as características evolutivas clínico-eletrencefalográficas de 14 crianças com epilepsia occipital benigna da infância de início precoce (tipo Panayiotopoulos. O tempo médio de segmento foi 50,5 meses. A idade média na primeira crise foi 3,7 anos. O número total de crises foi até 3 crises em 11 casos, numerosas em 3; o período médio entre a primeira e a última crise foi 14,5 meses. Em 4 casos as crises tiveram duração prolongada, constituindo estado de mal parcial. Atividade epileptiforme (AE occipital foi observada em todos os casos no primeiro EEG e, foi também, extra-occipital, em 3 casos. Houve bloqueio da AE occipital, pela abertura dos olhos, em 4 casos; em 3 casos foram observadas, também, pontas evocadas. O EEG normalizou-se em 9 casos, em um período médio de 29 meses.We studied clinical and electroencephalographic features of 14 children, age range of 2 -8 years, with no neurological or neuroradiological evidence of brain damage and with occipital epileptiform activity in the EEG. Seizures were numerous in 3 cases. Age at onset was between 1-7 years. In 4 cases the seizures last for more than 20 min. Spikes were observed in 6 cases and spike and slow-wave complex in 8. Discharges blocking by eyes opening were confirmed in 4 cases. Somatosensory evoked spikes by foot stimulation were observed in 2 cases. Autonomic and versive seizures are the main clinical manifestations of Panayiotopoulos syndrome. Discharges blocking by eyes opening are a less frequent feature.

  11. Sensing actin dynamics: Structural basis for G-actin-sensitive nuclear import of MAL

    Energy Technology Data Exchange (ETDEWEB)

    Hirano, Hidemi; Matsuura, Yoshiyuki, E-mail: matsuura.yoshiyuki@d.mbox.nagoya-u.ac.jp

    2011-10-22

    Highlights: {yields} MAL has a bipartite NLS that binds to Imp{alpha} in an extended conformation. {yields} Mutational analyses verified the functional significance of MAL-Imp{alpha} interactions. {yields} Induced folding and NLS-masking by G-actins inhibit nuclear import of MAL. -- Abstract: The coordination of cytoskeletal actin dynamics with gene expression reprogramming is emerging as a crucial mechanism to control diverse cellular processes, including cell migration, differentiation and neuronal circuit assembly. The actin-binding transcriptional coactivator MAL (also known as MRTF-A/MKL1/BSAC) senses G-actin concentration and transduces Rho GTPase signals to serum response factor (SRF). MAL rapidly shuttles between the cytoplasm and the nucleus in unstimulated cells but Rho-induced depletion of G-actin leads to MAL nuclear accumulation and activation of transcription of SRF:MAL-target genes. Although the molecular and structural basis of actin-regulated nucleocytoplasmic shuttling of MAL is not understood fully, it is proposed that nuclear import of MAL is mediated by importin {alpha}/{beta} heterodimer, and that G-actin competes with importin {alpha}/{beta} for the binding to MAL. Here we present structural, biochemical and cell biological evidence that MAL has a classical bipartite nuclear localization signal (NLS) in the N-terminal 'RPEL' domain containing Arg-Pro-X-X-X-Glu-Leu (RPEL) motifs. The NLS residues of MAL adopt an extended conformation and bind along the surface groove of importin-{alpha}, interacting with the major- and minor-NLS binding sites. We also present a crystal structure of wild-type MAL RPEL domain in complex with five G-actins. Comparison of the importin-{alpha}- and actin-complexes revealed that the binding of G-actins to MAL is associated with folding of NLS residues into a helical conformation that is inappropriate for importin-{alpha} recognition.

  12. Lesiones benignas de mama que pueden simular un carcinoma en estudios imagenológicos Benign breast lesions that mimic carcinoma in diagnostic imaging

    Directory of Open Access Journals (Sweden)

    Mariana Castro Barba

    2011-03-01

    Full Text Available La mayoría de las lesiones que se encuentran al realizar estudios mamarios son benignas. Muchas de ellas tienen un aspecto típico y definido, ya sea en mamografía o ecografía y no requieren de evaluaciones adicionales. Existe un grupo de entidades benignas que, sin embargo, puede simular un carcinoma en las imágenes. Los radiólogos debemos conocer las características de las mismas y tenerlas en cuenta como posibles diagnósticos diferenciales de una imagen de alta sospecha.Most of the lesions found during breast imaging exams are benign. Many of them have a typical and definite appearance on mammography and ultrasound, and require no further evaluation. However, some benign lesions cannot be differentiated from carcinomas, given their suspicious and less specific radiological features. Radiologists should be aware of the imaging characteristics of these lesions and include them in the differential diagnosis of a malignant-appearing finding.

  13. Síndrome de Brown bilateral associada com hipermobilidade articular benigna: relato de caso Bilateral Brown's syndrome associated with benign joint hypermobility: a case report

    Directory of Open Access Journals (Sweden)

    David Kirsch

    2007-03-01

    Full Text Available A síndrome de Brown é caracterizada por grande limitação de elevação em adução, elevação ligeiramente diminuída ou normal na abdução, anisotropia em "Y" ou "V", intorção do olho em supraversão e ducção forçada positiva. Sua causa se deve à inelastibilidade do músculo oblíquo superior ou por sua contenção em sua própria bainha. A hipermobilidade articular benigna é doença hereditária do tecido conectivo caracterizada por aumento da mobilidade em diversas articulações. Sua prevalência é muito variável em relação à idade, sexo e etnia, variando de 2 a 35% em homens e de 5 a 57% e mulheres. Neste relato os autores descrevem um caso de síndrome de Brown associada com hipermobilidade articular benigna e atentam para a associação pouco referida na literatura. J.C.S, masculino, 6 anos de idade, pardo, estudante, foi encaminhado à Universidade de Santo Amaro com queixa de exotropia há dois anos que aumentava na supraversão. Paciente com o diagnóstico de síndrome de Brown bilateral teve o diagnóstico de hipermobilidade articular benigna pelo Reumatologista. O paciente com hipermobilidade articular benigna pode desenvolver sintomas articulares como artralgia devido a uma inflamação articular. Acreditamos na possibilidade de que síndrome de Brown possa ter ocorrido devido a processo inflamatório na tróclea que teve início devido a hipermobilidade articular benigna.Brown's syndrome is characterized by a limitation of elevation in adduction, slight or normal limitation of elevation in abduction, divergence in straight upgaze (V-pattern, intorsion in upgaze and positive forced duction. It is caused by a tight or inelastic superior oblique tendon. Benign joint hypermobility is a hereditary disease of the connective tissue characterized by an increase of mobility in diverse joints. Its prevalence is very changeable regarding age range, sex and ethnicity, varying from 2 to 35% in men and 5 to 57% in women. In

  14. Integrating electrodermal biofeedback into pharmacologic treatment of grand mal seizures.

    Science.gov (United States)

    Scrimali, Tullio; Tomasello, Damiana; Sciuto, Massimo

    2015-01-01

    Electrodermal activity (EDA) and electrodermal biofeedback, when integrated with pharmacologic treatments, indicate promising methods for the treatment of grand mal seizures. They can be used to monitor patient arousal and help patients learn new strategies to better cope with stress and anxiety. Our proposed method can possibly reduce the number of crises for patients who are dependent on pharmacologic therapy and can improve their quality of life. This article describes the scientific background of electrodermal monitoring and electrodermal biofeedback for patients affected by grand mal seizures. In this study, we have reported a clinical case study. The patient was treated for 2 years with electrodermal biofeedback to augment pharmacologic treatments. The trial has been designed in accordance with "n = 1 case study research". Our results have shown that our methods could achieve a significant reduction in grand mal seizures and sympathetic arousal when applied. The patient under consideration was also relaxed and exhibited greater competency to cope with stress. Additionally, the patient's sense of mastery and self-efficacy was enhanced. PMID:26029078

  15. Mucin 1 (MUC1 is a novel partner for MAL2 in breast carcinoma cells

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    McGuckin Michael A

    2009-01-01

    Full Text Available Abstract Background The MAL2 gene, encoding a four-transmembrane protein of the MAL family, is amplified and overexpressed in breast and other cancers, yet the significance of this is unknown. MAL-like proteins have trafficking functions, but their molecular roles are largely obscure, partly due to a lack of known binding partners. Methods Yeast two-hybrid screening of a breast carcinoma cDNA expression library was performed using a full-length MAL2 bait, and subsequent deletion mapping experiments were performed. MAL2 interactions were confirmed by co-immunoprecipitation analyses and confocal microscopy was employed to compare protein sub-cellular distributions. Sucrose density gradient centrifugation of membranes extracted in cold Triton X-100 was employed to compare protein distributions between Triton X-100-soluble and -insoluble fractions. Results The tumor-associated protein mucin 1 (MUC1 was identified as a potential MAL2 partner, with MAL2/MUC1 interactions being confirmed in myc-tagged MAL2-expressing MCF-10A cells using co-immunoprecipitation assays. Deletion mapping experiments demonstrated a requirement for the first MAL2 transmembrane domain for MUC1 binding, whereas the MAL2 N-terminal domain was required to bind D52-like proteins. Confocal microscopy identified cytoplasmic co-localisation of MUC1 and MAL2 in breast cell lines, and centrifugation of cell lysates to equilibrium in sucrose density gradients demonstrated that MAL2 and MUC1 proteins were co-distributed between Triton X-100-soluble and -insoluble fractions. However co-immunoprecipitation analyses detected MAL2/MUC1 interactions in Triton X-100-soluble fractions only. Myc-MAL2 expression in MCF-10A cells was associated with both increased MUC1 detection within Triton X-100-soluble and -insoluble fractions, and increased MUC1 detection at the cell surface. Conclusion These results identify MUC1 as a novel MAL2 partner, and suggest a role for MAL2 in regulating MUC1

  16. Acción de Finasteride sobre el volumen prostático en caninos con hiperplasia prostática benigna

    OpenAIRE

    Stornelli, María Alejandra; Stornelli, María Cecilia; Rodríguez, R.; Scodellaro, Carla Floriana; Savignone, César A.

    2002-01-01

    Se administró 0,1 mg/kg día de Finasteride, inhibidor selectivo de la 5 αreductasa, vía oral a caninos machos adultos con diferentes grados de hiperplasia prostática benigna. Se evaluó, mediante ecografía, el efecto de la droga sobre el tamaño prostático. Finasteride provocó importante disminución del tamaño glandular y no se asoció a efectos tóxicos colaterales. La dosis utilizada fue 10 veces inferior a la utilizada por otros autores, sin embargo se lograron resultados similares a los obten...

  17. Portable device for detection of petit mal epilepsy

    Science.gov (United States)

    Smith, R. G.; Houge, J. C.; Webster, J. G.

    1979-01-01

    A portable device that analyzes the electroencephalogram to determine if petit mal epilepsy waveforms are present is developed and tested. Clinicians should find it useful in diagnosing seizure activity of their patients. The micropower, battery-operated, portable device indicates a seizure has occurred if three criteria are satisfied: (1) frequencies of 2.5-7 Hz, (2) large-amplitude waves, and (3) minimum number of waves per second. Levels and counts are adjustable, thus insuring high reliability against noise artifacts and permitting each subject to be individually fitted. The device has shown promise in giving the patient a possible mechanism of seizure control or suppression.

  18. Polirradiculoneurite e malária: relato de um caso

    Directory of Open Access Journals (Sweden)

    Carlos A. M. Guerreiro

    1985-06-01

    Full Text Available Registro de caso de paciente que três semanas após malária por Plasmodium falciparum desenvolveu forma severa de polirradiculoneurite, com tetraplegia e comprometimento de vários nervos cranianos (VI, VII, IX, X, evoluindo para a morte. A síndrome de Guillain-Barré tem sido considerada desordem imune relacionada a diversos estímulos antigênicos desencadeantes. O caso registrado sugere que protozoários podem ser um desses fatores antigênicos.

  19. The malQ gene is essential for starch metabolism in Streptococcus mutans

    Directory of Open Access Journals (Sweden)

    Yutaka Sato

    2013-08-01

    Full Text Available Background: The malQ and glgP genes, respectively, annotated as putative 4-α-glucanotransferase and putative glycogen phosphorylase are located with a 29 nucleotide overlap on the Streptococcus mutans genome. We found that the glgP gene of this organism was induced with maltose, and the gene likely constituted an operon with the upstream gene malQ. This putative operon was negatively regulated with the malR gene located upstream from the malQ gene and a MalR-binding consensus sequence was found upstream of the malQ gene. S. mutans is not able to catabolize starch. However, this organism utilizes maltose degraded from starch in the presence of saliva amylase. Therefore, we hypothesized that the MalQ/GlgP system may participate in the metabolism of starch-degradation products. Methods: A DNA fragment amplified from the malQ or glgP gene overexpressed His-tagged proteins with the plasmid pBAD/HisA. S. mutans malQ and/or glgP mutants were also constructed. Purified proteins were assayed for glucose-releasing and phosphorylase activities with appropriate buffers containing maltose, maltotriose, maltodextrin, or amylodextrin as a substrate, and were photometrically assayed with a glucose-6-phosphate dehydrogenase–NADP system. Results: Purified MalQ protein released glucose from maltose and maltotriose but did not from either maltodextrin or amylodextrin. The purified GlgP protein did not exhibit a phosphorylase reaction with maltose or maltotriose but generated glucose-1-phosphate from maltodextrin and amylodextrin. However, the GlgP protein released glucose-1-phosphate from maltose and maltotriose in the presence of the MalQ protein. In addition, the MalQ enzyme activity with maltose released not only glucose but also produced maltooligosaccharides as substrates for the GlgP protein. Conclusion: These results suggest that the malQ gene encodes 4-α-glucanotransferase but not α-1,4-glucosidase activity. The malQ mutant could not grow in the

  20. Interní audit v malé organizaci.

    OpenAIRE

    Obůrka, Miloš

    2008-01-01

    Účelem této bakalářské práce bylo zpracovat literární rešerši na téma interní audit v malé organizaci a z takto provedeného průzkumu vyvodit vlastní závěry. Obsahuje seznámení s průběhem auditů se zaměřením na interní audity včetně specifických odlišností auditování v malých organizacích. Vytváří přehled současného stavu interních auditů s výhledem na budoucí koncept auditů. The purpose of this bachelor thesis was the elaboration of the literary recherché on the topic of internal auditing ...

  1. Projetos de Prefácios de As Flores do Mal, de Charles Baudelaire

    Directory of Open Access Journals (Sweden)

    Charles Baudelaire

    2009-04-01

    Full Text Available RESUMO: O trabalho consiste na tradução dos quatro projetos de prefácios que Baudelaire escreveu para As Flores do Mal, cujos rascunhos foram publicados apenas postumamente. PALAVRAS-CHAVE: Charles Baudelaire, As Flores do Mal, Crítica literária, Poesia, Tradução.

  2. Effect of postharvest storage on the expression of the apple allergen Mal d 1

    NARCIS (Netherlands)

    A.I. Sancho; R. Foxall; T. Browne; R. dey; L. Zuidmeer; G. Marzban; K.W. Waldron; R. van Ree; K. Hoffmann-Sommergruber; M. Laimer; E.N.C. Mills

    2006-01-01

    Consumption of fresh apples can cause allergy in susceptible individuals. A competitive enzyme-linked immunosorbent assay ( ELISA) has been developed to determine Mal d 1 levels in apple pulp using a monoclonal antibody (BIP-1). The ELISA was able to rank ten cultivars according to their Mal d 1 con

  3. Epigenetic silencing of MAL, a putative tumor suppressor gene, can contribute to human epithelium cell carcinoma

    Directory of Open Access Journals (Sweden)

    Zhang Jun

    2010-11-01

    Full Text Available Abstract Background To identify new and useful candidate biomarkers in head and neck squamous cell carcinoma (HNSCC, we performed a genome-wide survey and found that Myelin and lymphocyte-associated protein (MAL was a gene that was markedly down-regulated in HNSCC. Hence, we investigated the mechanism of MAL silencing and the effects of MAL on the proliferation, invasion, and apoptotic potential in HNSCC. Results MAL was significantly down-regulated in 91.7% of HNSCC specimens at the mRNA level as compared with adjacent normal tissues (P = 0.0004. Moreover, the relative transcript levels of the MAL gene were remarkably decreased by five-fold in nine HNSCC cell lines as compared with normal head and neck epithelium cells. MAL gene expression was restored in 44%, 67%, and 89% in HNSCC cell lines treated with TSA, 5-Aza-dC, and TSA plus 5-Aza-dC, respectively. Furthermore, bisulfate-treated DNA sequencing demonstrated that the two CpG islands (that is, M1 and M2 located in MAL promoter region were completely methylated in the HNSCC cell lines (CpG methylated ratio was more than 90%, and only one CpG island (that is, M1 was partially methylated in HNSCC tissues (CpG methylated ratio between 20% and 90%. A significant reduction in cell proliferation and a change in the cell cycle profile were also observed in MAL transfectants. Matrigel assay demonstrated that the invasiveness of HNSCC cells significantly decreased. A significant increase in the population of apoptotic cells was observed in MAL transfected cells. The exogenous expression of the MAL gene suppressed malignant phenotypes, while the cell death induced by MAL gene transfer was a result of apoptosis as demonstrated by the induction of cleavage of the poly (that is, ADP-ribose polymerase. Additionally, tumor growth was suppressed in cells expressing MAL as compared with cells not expressing MAL. Conclusion Our data suggest that the epigenetic inactivation of MAL, as a candidate tumor

  4. Literatura y competencia comunicativa: ¿matrimonio mal avenido?

    Directory of Open Access Journals (Sweden)

    Ximena Troncoso Araos

    2014-12-01

    Full Text Available Este artículo aborda la relación problemática entre enseñanza de la literatura y enfoque comunicacional, específicamente, entre aprender literatura y desarrollar la competencia comunicativa. A partir de esta tensión diagnosticada, surgen las preguntas: ¿es plausible enseñar literatura desarrollando a la vez competencias comunicativas?, ¿es compatible la literatura con un enfoque comunicativo? Estas interrogantes consideran una premisa: entender la literatura como dominio con características diferenciales. Luego, se somete a prueba, desde una perspectiva literaria y didáctica, la hipótesis que es posible desarrollar competencia comunicativa sin descuidar la especificidad y potencialidad de la literatura. Para ello, se analizan diversos textos en relación con cuatro subcompetencias: léxico-semántica, textual, discursiva y sociocognitiva. Si bien una misma obra podría analizarse en función de todas estas subcompetencias, se consideran por separado para efectos de la investigación. El análisis contempla textos principalmente narrativos y algunos líricos, sin distinción de edad. Esto evidencia que es factible desarrollar las subcompetencias en distintos niveles educacionales, aunque regulando la pertinencia de los textos y el tratamiento didáctico. En términos globales, se concluye que es posible compatibilizar competencia comunicativa y literatura considerando los énfasis específicos de lo literario y sus consecuentes derivaciones didácticas.

  5. Mal de Pott en niños

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    Patricia Campos

    1989-09-01

    Full Text Available Se presentan 27 casos de mal de Pott en niños entre 6 meses y 14 años de edad vistos durante un período de 2 años con tiempo de seguimiento hasta de 18 meses, 67% menores de 6 años y de ellos 2 pacientes menores de 1 año. Hubo predominio de pacientes de sexo masculino. El síntoma "jiba" fue el mas frecuente. La localización mas frecuente de la lesión fue el nivel dorsal. Todos recibieron tratamiento médico con 4 drogas, 14 de ellos necesitaron de métodos ortopédicos y solo 6 fueron sometidos a corrección quirúrgica. En mas del 50% hubo una evolución favorable hacia la curación o la mejoría con secuelas.

  6. LA PREOCUPACIÓN, MAL DE NUESTROS DÍAS

    Directory of Open Access Journals (Sweden)

    Alberto Ferrer Botero

    2002-01-01

    Full Text Available En este artículo, Alberto Ferrer nos muestra la preocupación como un problema central en la salud mental. Deduce que probablemente ésta es una de las razones del subdesarrollo de nuestros pueblos, ya que existe la influencia cultural que nos inculca la asociación entre la responsabilidad y preocupación. Nos lleva a concluir que si bien la preocupación tiene funciones normales y adaptativas (la alarma ante eventuales amenazas que sirve como anticipación de estrategias de supervivencia, quedarse en ella es algo patológico, ya que genera sufrimiento e inmovilidad. Por tal motivo, resalta la importancia de trabajar con el paciente la terapia cognitiva, la cual ha demostrado estar preparada para enfrentar la preocupación, ese «mal de nuestros días».

  7. [Clonage of the "malA" region of "Escherichia coli" K12: nucleotide sequence of the regulatory region and the promoters, identification and purification of the MalT-activator protein (author's transl)].

    Science.gov (United States)

    Raibaud, O; Débarbouillé, M; Cossart, P

    1982-01-01

    A 5,800-bp (base pair) HindIII-EcoRI DNA fragment containing malT, the positive regulator gene of the maltose regulon, and most of malP, the structural gene for maltodextrin phosphorylase, was cloned into pBR322. A sequence of 802 bp was established in a DNA segment containing the promotor for malPQ and the promoter for malT. A total of 611 bp separates the initiation codons for these two genes, which are transcribed in opposite directions. The malT product was identified as a 94,000 dalton polypeptide. PMID:6462088

  8. MalY of Escherichia coli is an enzyme with the activity of a beta C-S lyase (cystathionase).

    OpenAIRE

    Zdych, E; Peist, R; Reidl, J.; Boos, W

    1995-01-01

    The Escherichia coli maltose system consists of a number of genes whose products are involved in the uptake and metabolism of maltose and maltodextrins. MalT is the central positive gene activator of the regulon and is, together with the cyclic AMP-catabolite gene activator protein system, necessary for the expression of the maltose genes. Expression of malY, a MalT-independent gene, leads to the repression of all MalT-dependent genes. We have purified MalY to homogeneity and found it to be a...

  9. Identification and characterization of MalA in the maltose/maltodextrin operon of Sulfolobus acidocaldarius DSM639.

    Science.gov (United States)

    Choi, Kyoung-Hwa; Hwang, Sungmin; Cha, Jaeho

    2013-04-01

    A putative maltose/maltodextrin operon was found in the Sulfolobus acidocaldarius DSM639 genome. The gene cluster consisted of 7 genes (malA, trmB, amyA, malG, malF, malE, and malK). Here, we report the identification of MalA, which is responsible for the hydrolysis of maltose or maltodextrin to glucose in S. acidocaldarius. The transcription level of malA was increased 3-fold upon the addition of maltose or starch to the medium. Moreover, the α-glucosidase activity for maltose as a substrate in cell extracts of S. acidocaldarius DSM639 was also 11- and 10-fold higher during growth in YT medium (Brock's mineral salts, 0.1% [wt/vol] tryptone, and 0.005% [wt/vol] yeast extract) containing maltose or starch, respectively, than during growth on other sugars. The gene encoding MalA was cloned and expressed in S. acidocaldarius. The enzyme purified from the organism was a dodecamer in its active state and showed strong maltose-hydrolyzing activity at 100°C and pH 5.0. MalA was remarkably thermostable, with half-lives of 33.8 h, 10.6 h, and 1.8 h at 95°C, 100°C, and 105°C, respectively. Substrate specificity and kinetic studies of MalA with maltooligosaccharides indicated that MalA efficiently hydrolyzed maltose to maltopentaose, which is a typical characteristic of GH31-type α-glucosidases. However, glycogen or starch was not hydrolyzed. Reverse transcription-PCR, sugar uptake, and growth studies of the wild-type DSM639 and ΔmalEFG mutant on different sugars demonstrated that MalA located in the mal operon gene cluster is involved in maltose and starch metabolism in S. acidocaldarius.

  10. "Kevad uhkelt sammub mal kui jumalanna..." : [luuletused] / Ljubov Dergatshova ; tlk. Arvo Valton

    Index Scriptorium Estoniae

    Dergatshova, Ljubov

    2006-01-01

    Sisu: "Kevad uhkelt sammub mal kui jumalanna..." ; "Maga, pojake, maga mu päike..." ; "Mis kaunis õhtu! Lumi tahke..." ; "Raskel tunnil sirutab kes käe...". Luuletused paralleelselt ersa ja eesti keeles

  11. Estados de mal epiléptico na sindrome Delennox-Gastaut: aspectos terapeuticos

    Directory of Open Access Journals (Sweden)

    José Geraldo Speciali

    1977-09-01

    Full Text Available Foram descritas as condutas terapêuticas utilizadas nos estados de mal epiléptico, convulsivos e não convulsivos, observados em 14 pacientes com síndrome de Lennox-Gastaut. Verificou-se relação temporal entre aparecimento de estado de mal epiléptico e início de tratamento com clonazepam e difenilhidantoina; a retirada dessas medicações foi seguida pelo desaparecimento dos estados de mal. Indicou-se a possibilidade de tratamento dos estados de mal epiléptico modificando-se o esquema terapêutico administrado por via oral, reservando-se o tratamento parenteral para os estados com comprometimento progressivo da consciência e/ou dos distúrbios neurovegetativos.

  12. X-ray structure of MalY from Escherichia coli: a pyridoxal 5′-phosphate-dependent enzyme acting as a modulator in mal gene expression

    OpenAIRE

    Clausen, Tim; Schlegel, Anja; Peist, Ralf; Schneider, Eva; Steegborn, Clemens; Chang, Yuh-Shin; Haase, Andrea; Bourenkov, Gleb P.; Bartunik, Hans D.; Boos, Winfried

    2000-01-01

    MalY represents a bifunctional pyridoxal 5′-phosphate-dependent enzyme acting as a β–cystathionase and as a repressor of the maltose regulon. Here we present the crystal structures of wild-type and A221V mutant protein. Each subunit of the MalY dimer is composed of a large pyridoxal 5′-phosphate-binding domain and a small domain similar to aminotransferases. The structural alignment with related enzymes identifies residues that are generally responsible for β–lyase activity and depicts a uniq...

  13. Diagnóstico tardio de malária em área endêmica de dengue na extra-Amazônia Brasileira: experiência recente de uma unidade sentinela no estado do Rio de Janeiro Delayed diagnosis of malaria in a dengue endemic area in the Brazilian extra-Amazon: recent experience of a malaria surveillance unit in state of Rio de Janeiro

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    Anielle de Pina Costa

    2010-10-01

    Full Text Available INTRODUÇÃO: A letalidade da malária na região extra-amazônica é cerca de 80 vezes maior do que na Amazônia, que concentra 99,8% dos casos do país. Em áreas de transmissão de dengue, como o Rio de Janeiro, o atraso no diagnóstico e tratamento da malária dos pacientes com febre, provenientes de áreas endêmicas de malária, pode ser, entre outros fatores, devido à confusão entre o diagnóstico das duas doenças pelos generalistas da rede de assistência médica. Neste trabalho, apresentamos as consequências do atraso diagnóstico em três pacientes com malária por Plasmodium falciparum; P. malariae e P. vivax, que, após o périplo habitual para tratamento de dengue, procuraram a nossa instituição onde foram corretamente diagnosticados e submetidos aos tratamentos adequados. MÉTODOS: Descrição de três casos de malária diagnosticada tardiamente e encaminhados ao IPEC/ FIOCRUZ, entre os anos de 2007 e 2008. RESULTADOS: uma brasileira proveniente de Moçambique, primo-infectada por P. falciparum, com malária diagnosticada após 6 dias do início da febre, morreu com malária cerebral e choque. Outro paciente com malária por P. malariae teve um curso grave e prolongado, mas ficou curado após o tratamento específico. A terceira paciente diagnosticada tardiamente apresentou malária por P. vivax adquirida na região de Mata Atlântica no Estado do Rio. CONCLUSÕES: Os profissionais de saúde do Rio devem ser treinados para aperfeiçoar a vigilância e o tratamento oportuno da malária e evitar desfechos mórbidos e fatais. Sugere-se que uma investigação de focos de malária autóctone em áreas de mata no estado seja realizada.INTRODUCTION: The mortality of malaria in the extra-Amazon region is about 80 times higher than in the Amazon region, where malaria is concentrated (99.8% of cases. In areas of dengue transmission, delay in the diagnosis and treatment of malaria in patients with fever who reside in areas of malaria

  14. Sobre el mal radical. Ensayo de la heterodoxia kantiana

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    Gómez Caffarena, José

    2004-06-01

    Full Text Available The kantian theory of a «radical evil inhabiting human nature» contrasts with a general anthropological optimistic tenor perceptible in kantian philosophy. It meant a significant turning point in the often too superficial optimistic trends of the Enlightenment. Hut its literal sense (appealing to an act of pre-individual freedom has an obvious difficulty. The present paper proposes an heterodox interpretation, which would avoid the difficulty, although so losing part of the tempting enigmatic reach of the kantian proposal.

    La teoría del «mal radical en la naturaleza humana», expuesta por Kant en La religión dentro de los límites de la mera razón, hace contraste con el optimismo antropológico que empapa el Criticismo. Constituyó, sin duda, una importante denuncia frente a la banalidad de muchos optimismos ilustrados. Pero su letra (acto de libertad pre-individual tiene una obvia dificultad. El artículo propone una reinterpretación que la evitaría, aunque desdramatizando un tanto el tentador alcance enigmático de la propuesta kantiana.

  15. Sobre a psicogênese do "mal de engasgo"

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    Durval Marcondes

    1947-06-01

    Full Text Available O A. ressalta o aspecto psicológico da etiologia do cardiospasmo ou mal de engasgo, assunto até agora não abordado nos meios científicos brasileiros. Sem pretender afastar outros elementos causais que tenham sido, porventura, verificados e que poderão, talvez, agir concomitantemente, o A. é de opinião que o mal de engasgo é um disturbio funcional condicionado psìquicamente, cujas conseqüências se tornam irreversíveis depois de certo tempo. As conclusões apresentadas baseiam-se no material fornecido por pacientes em tratamento psicanalítico que apresentam fenômenos disfágicos, e por vários casos das clínicas de orientação infantil entre cujos problemas se incluem, além da dificuldade de engulir, a anorexia e a bulimia. Com respeito às atividades emocionais típicas que formam o substrato psicológico do mal de engasgo, o ponto fundamental está em que êste representa um compromisso, expresso ao nível oral, entre tendências passivo-receptivas e ativo-expulsivas. A essa situação psíquica correspondem condições de ambiente, atuais ou pretéritas, que, de modo contraditório, favorecem uma atitude de dependência infantil, ao mesmo tempo que acarretam repetidas frustrações. Trata-se, em geral, de mães dominadoras que, enquanto superprotegem a criança, agem para com ela com demasiado rigor. A superproteção centraliza-se sobretudo no que se refere aos alimentos, que se investem, assim, de grande significado emocional. O A. apresenta o resumo de uma observação clínica que apoia seu ponto de vista. Também a anorexia e a bulimia, em seu substrato psicodinâmico, estão relacionadas com o problema do apego e da emancipação e giram em torno da pessoa da mãe e da função alimentar. A solução do conflito faz-se, porém, num dos casos, pela rejeição do alimento e, noutro, pela avidez. O mal de engasgo constitui o meio têrmo entre os dois extremos. Existem, igualmente, nas neuroses gástricas e em sua conseq

  16. Mal de Meleda with Lip Involvement: A Report of Two Cases

    OpenAIRE

    Amiya Kumar Nath; Sangita Chaudhuri; Devinder Mohan Thappa

    2012-01-01

    Mal de Meleda is a rare autosomal recessive transgradient palmoplantar keratoderma characterized by transgradient keratoderma with associated scleroatrophy, nail changes, pseudoainhum around digits and perioral erythema, without a tendency for spontaneous resolution. Involvement of the lip by keratoderma has not been reported in the English literature. Here we present two cases of Mal de Meleda with unusual lip involvement. The first case was a 15-year-old girl, born of second-degree consangu...

  17. Effect of postharvest storage on the expression of the apple allergen Mal d 1.

    Science.gov (United States)

    Sancho, Ana I; Foxall, Robert; Browne, Tom; Dey, Rickmer; Zuidmeer, Laurian; Marzban, Gorji; Waldron, Keith W; van Ree, Ronald; Hoffmann-Sommergruber, Karin; Laimer, Margit; Mills, E N Clare

    2006-08-01

    Consumption of fresh apples can cause allergy in susceptible individuals. A competitive enzyme-linked immunosorbent assay (ELISA) has been developed to determine Mal d 1 levels in apple pulp using a monoclonal antibody (BIP-1). The ELISA was able to rank ten cultivars according to their Mal d 1 content (between 3.8 and 72.5 mug/g pulp). For the first time, it has been demonstrated that growing conditions and postharvest storage, using three different treatments over a 5 month period in 2 consecutive years, increase Mal d 1 expression at a translational and transcriptional level (3.5- and 8.5-fold under controlled atmosphere storage). Expression of three major Mal d 1 isoforms was observed by real-time polymerase chain reaction over the 5 month storage period, and Mal d 1.02 was the most highly expressed isoform. In conclusion, Mal d 1 gene expression was significantly increased during modified atmosphere storage. Individuals suffering from birch pollen-apple allergy syndrome might experience fewer problems consuming freshly picked apples.

  18. Assessment of allelic diversity in intron-containing Mal d 1 genes and their association to apple allergenicity

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    Bolhaar Suzanne THP

    2008-11-01

    Full Text Available Abstract Background Mal d 1 is a major apple allergen causing food allergic symptoms of the oral allergy syndrome (OAS in birch-pollen sensitised patients. The Mal d 1 gene family is known to have at least 7 intron-containing and 11 intronless members that have been mapped in clusters on three linkage groups. In this study, the allelic diversity of the seven intron-containing Mal d 1 genes was assessed among a set of apple cultivars by sequencing or indirectly through pedigree genotyping. Protein variant constitutions were subsequently compared with Skin Prick Test (SPT responses to study the association of deduced protein variants with allergenicity in a set of 14 cultivars. Results From the seven intron-containing Mal d 1 genes investigated, Mal d 1.01 and Mal d 1.02 were highly conserved, as nine out of ten cultivars coded for the same protein variant, while only one cultivar coded for a second variant. Mal d 1.04, Mal d 1.05 and Mal d 1.06 A, B and C were more variable, coding for three to six different protein variants. Comparison of Mal d 1 allelic composition between the high-allergenic cultivar Golden Delicious and the low-allergenic cultivars Santana and Priscilla, which are linked in pedigree, showed an association between the protein variants coded by the Mal d 1.04 and -1.06A genes (both located on linkage group 16 with allergenicity. This association was confirmed in 10 other cultivars. In addition, Mal d 1.06A allele dosage effects associated with the degree of allergenicity based on prick to prick testing. Conversely, no associations were observed for the protein variants coded by the Mal d 1.01 (on linkage group 13, -1.02, -1.06B, -1.06C genes (all on linkage group 16, nor by the Mal d 1.05 gene (on linkage group 6. Conclusion Protein variant compositions of Mal d 1.04 and -1.06A and, in case of Mal d 1.06A, allele doses are associated with the differences in allergenicity among fourteen apple cultivars. This information

  19. Metabolic and functional connectivity changes in mal de debarquement syndrome.

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    Yoon-Hee Cha

    Full Text Available BACKGROUND: Individuals with mal de debarquement syndrome (MdDS experience a chronic illusion of self-motion triggered by prolonged exposure to passive motion, such as from sea or air travel. The experience is one of rocking dizziness similar to when the individual was originally on the motion trigger such as a boat or airplane. MdDS represents a prolonged version of a normal phenomenon familiar to most individuals but which persists for months or years in others. It represents a natural example of the neuroplasticity of motion adaptation. However, the localization of where that motion adaptation occurs is unknown. Our goal was to localize metabolic and functional connectivity changes associated with persistent MdDS. METHODS: Twenty subjects with MdDS lasting a median duration of 17.5 months were compared to 20 normal controls with (18F FDG PET and resting state fMRI. Resting state metabolism and functional connectivity were calculated using age, grey matter volume, and mood and anxiety scores as nuisance covariates. RESULTS: MdDS subjects showed increased metabolism in the left entorhinal cortex and amygdala (z>3.3. Areas of relative hypometabolism included the left superior medial gyrus, left middle frontal gyrus, right amygdala, right insula, and clusters in the left superior, middle, and inferior temporal gyri. MdDS subjects showed increased connectivity between the entorhinal cortex/amygdala cluster and posterior visual and vestibular processing areas including middle temporal gyrus, motion sensitive area MT/V5, superior parietal lobule, and primary visual cortex, while showing decreased connectivity to multiple prefrontal areas. CONCLUSION: These data show an association between resting state metabolic activity and functional connectivity between the entorhinal cortex and amygdala in a human disorder of abnormal motion perception. We propose a model for how these biological substrates can allow a limited period of motion exposure to lead

  20. En busca de una vacuna anti-malárica

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    Edith Suzarte Portal

    2009-01-01

    Full Text Available El desarrollo e implementación de una vacuna contra la malaria representa una necesidad médica urgente para la población que habita las regiones donde ella es endémica. En los últimos años, se han visto progresos significativos en el desarrollo de vacunas, con numerosos candidatos iniciando evaluación en ensayos clínicos. A pesar del optimismo y algunos resultados prometedores, hasta el momento no se cuenta con una vacuna efectiva, en parte, por la falta de conocimiento del tipo de respuesta inmune necesaria para la protección. A esto, se adiciona la dificultad de identificar, seleccionar y producir los antígenos protectores del parásito que posee más de 5 000 genes y un ciclo de vida complejo. Por otra parte, el gran polimorfismo de los antígenos de Plasmodium y los diferentes mecanismos que utiliza para evadir la respuesta inmune hacen necesario aumentar la inmunogenicidad de los antígenos purificados, a través del uso de nuevos adyuvantes o sistemas de liberación. El reto no es meramente científico, se necesita involucrar investigadores competentes, lograr colaboración entre academias, industrias y agencias financiadoras y comprometimiento político. Actualmente, se ensayan diferentes estrategias dirigidas hacia los distintos estadios del parásito. En este manuscrito se destacan algunas de las más avanzadas, otras aún en fase preclínica y algunos fracasos, todas dirigidas contra P. falciparum, así como los principales retos a vencer en la búsqueda de una vacuna anti-malárica efectiva.

  1. Maturity and storage influence on the apple (Malus domestica) allergen Mal d 3, a nonspecific lipid transfer protein.

    Science.gov (United States)

    Sancho, Ana I; Foxall, Robert; Rigby, Neil M; Browne, Thomas; Zuidmeer, Laurian; van Ree, Ronald; Waldron, Keith W; Mills, E N Clare

    2006-07-12

    Consumption of apples can provoke severe allergic reactions, in susceptible individuals, due to the presence of the allergen Mal d 3, a nonspecific lipid transfer protein, found largely in the fruit skin. Levels of Mal d 3 were determined in peel as a function of apple cultivar, position of the fruit growing on the tree, apple maturity, and postharvest storage by ELISA. As the apples mature, Mal d 3 levels increased, although the rate was dependent on cultivar and tree position. During storage, levels of Mal d 3 decreased in all cultivars (cvs. Cox, Jonagored, and Gala), the rate of overall decrease being greatest under controlled atmosphere conditions. There was no correlation between Mal d 3 levels and total apple peel protein, indicating specific alterations in Mal d 3 expression. Thus pre- and postharvest treatments (i.e., storage) can modify the allergen load in apple peel, the highest levels being found in overly mature and freshly harvested fruits.

  2. Embolização das artérias prostáticas no tratamento da hiperplasia benigna da próstata : estudo anátomo-clínico

    OpenAIRE

    Bilhim, Tiago Campos Andrada de Faria

    2011-01-01

    Resumo: A hiperplasia benigna da próstata (HBP) tem elevada prevalência nos homens entre os 50 e 79 anos de idade, sendo ubiquitária com o envelhecimento. Devido à significativa morbi-mortalidade associada aos tratamentos médicos e cirúrgicos currentemente disponíveis, são necessárias novas tecnologias para melhorar os resultados e minimizar o desconforto dos doentes. Recentemente, estudos preliminares de experimentação animal e em 3 doentes tratados, sugeriram a embolização arter...

  3. Estudio retrospectivo de masas cutáneas neoplásicas en caninos diagnosticadas histopatológicamente en la Universidad de La Salle (1999-2003

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    Carlos Eduardo Aparicio Ortiz

    2008-12-01

    Full Text Available El propósito del trabajo fue realizar un análisis retrospectivo de las neoplasias cutáneas en caninos diagnosticadas en la Universidad de La Salle, en Bogotá, en el período 1999-2003. El presente estudio se llevó a cabo con la información obtenida de los registros del área diagnóstica e histopatológica de la Universidad de La Salle. La información fue discriminada y analizada teniendo en cuenta las siguientes variables: diagnóstico, raza, sexo, edad, malignidad y localización del tumor. Los 192 casos de pacientes abordados en el estudio fueron agrupados de acuerdo con las neoplasias con el fin de determinar las características y el comportamiento de dichas patologías. La edad promedio de los pacientes fue de 6,5 años, la raza más afectada el Bóxer con el 19,1% (32 perros, seguido del Labrador con un 13% (26 perros y el Caniche con un 10,5% (22 perros; los pacientes machos fueron los más afectados con un 58% (107 perros. Se reveló la gran incidencia del tumor de células de mast (26,2% en el 2003 y 20% en el 2002 y el histiocitoma (12,3% en el 2003 y 10% en el año 2002. Entre otras neoplasias que se observaron de forma recurrente en el estudio se destacan el lipoma, tricoepitelioma, carcinoma de células escamosas y papilomatosis.

  4. MalE of Group A Streptococcus Participates in the Rapid Transport of Maltotriose and Longer Maltodextrins▿ †

    Science.gov (United States)

    Shelburne, Samuel A.; Fang, Han; Okorafor, Nnaja; Sumby, Paul; Sitkiewicz, Izabela; Keith, David; Patel, Payal; Austin, Celest; Graviss, Edward A.; Musser, James M.; Chow, Dar-Chone

    2007-01-01

    Study of the maltose/maltodextrin binding protein MalE in Escherichia coli has resulted in fundamental insights into the molecular mechanisms of microbial transport. Whether gram-positive bacteria employ a similar pathway for maltodextrin transport is unclear. The maltodextrin binding protein MalE has previously been shown to be key to the ability of group A Streptococcus (GAS) to colonize the oropharynx, the major site of GAS infection in humans. Here we used a multifaceted approach to elucidate the function and binding characteristics of GAS MalE. We found that GAS MalE is a central part of a highly efficient maltodextrin transport system capable of transporting linear maltodextrins that are up to at least seven glucose molecules long. Of the carbohydrates tested, GAS MalE had the highest affinity for maltotriose, a major breakdown product of starch in the human oropharynx. The thermodynamics and fluorescence changes induced by GAS MalE-maltodextrin binding were essentially opposite those reported for E. coli MalE. Moreover, unlike E. coli MalE, GAS MalE exhibited no specific binding of maltose or cyclic maltodextrins. Our data show that GAS developed a transport system optimized for linear maltodextrins longer than two glucose molecules that has several key differences from its well-studied E. coli counterpart. PMID:17259319

  5. Contribución al conocimiento de los malófagos (Phthiraptera, Amblycera, Ischnocera de aves peruanas. Parte 1

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    Luis A. Gomez-Puerta

    2015-12-01

    Full Text Available En el presente trabajo se reporta nueve especies de malófagos colectados de aves peruanas. Dos malófagos Amblycera: Heteromenopon laticapitis y Menacanthus pici, así como siete malófagos Ischnocera: Alcedoffula theresae, Brueelia brunneinucha, Chelopistes meleagridis, Columbicola columbae, Paragoniocotes aratingae, Penenirmus jungens y Saemundssonia (Saemundssonia lari, fueron determinados mediante el diagnóstico morfológico. Se realiza una breve descripción de cada malófago, así como la discusión de sus hospederos y distribución.

  6. Interaction of PLP with GFP-MAL2 in the human oligodendroglial cell line HOG.

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    Raquel Bello-Morales

    Full Text Available The velocity of the nerve impulse conduction of vertebrates relies on the myelin sheath, an electrically insulating layer that surrounds axons in both the central and peripheral nervous systems, enabling saltatory conduction of the action potential. Oligodendrocytes are the myelin-producing glial cells in the central nervous system. A deeper understanding of the molecular basis of myelination and, specifically, of the transport of myelin proteins, will contribute to the search of the aetiology of many dysmyelinating and demyelinating diseases, including multiple sclerosis. Recent investigations suggest that proteolipid protein (PLP, the major myelin protein, could reach myelin sheath by an indirect transport pathway, that is, a transcytotic route via the plasma membrane of the cell body. If PLP transport relies on a transcytotic process, it is reasonable to consider that this myelin protein could be associated with MAL2, a raft protein essential for transcytosis. In this study, carried out with the human oligodendrocytic cell line HOG, we show that PLP colocalized with green fluorescent protein (GFP-MAL2 after internalization from the plasma membrane. In addition, both immunoprecipitation and immunofluorescence assays, indicated the existence of an interaction between GFP-MAL2 and PLP. Finally, ultrastructural studies demonstrated colocalization of GFP-MAL2 and PLP in vesicles and tubulovesicular structures. Taken together, these results prove for the first time the interaction of PLP and MAL2 in oligodendrocytic cells, supporting the transcytotic model of PLP transport previously suggested.

  7. The bacterial flora of the skin surface following routine MAL-PDT.

    Science.gov (United States)

    Bryld, Lars Eeik; Jemec, Gregor B E

    2006-01-01

    Photodynamic therapy using methylated 5-aminolevulate (MAL-PDT) appears to have an effect on non-neoplastic skin diseases, for example acne vulgaris and rosacea, for which antibiotics are sometimes used, and a possible antibiotic effect of PDT has previously been suggested. It does, however, also cause local immunosuppression and post-treatment barrier defects, which may promote infection. At the same time, PDT-induced therapeutic skin damage is sometimes confused with secondary bacterial infection by non-dermatologists. The possible changes in bacterial flora associated with MAL-PDT were therefore studied in 47 patients undergoing treatment. Skin swabs were taken immediately before applying the MAL and instantly after light irradiation. Bacterial growth was identified in 18 cases. No statistically significant changes were seen, either in the specific species found or the estimated bacterial density on the skin surface. The observations do not support the notion that routine MAL-PDT affects the bacterial flora of the skin in a clinically significant manner. Therefore, the possible antibacterial effect of routine MAL-PDT is probably not the main explanation of its apparent effect on non-neoplastic skin disease.

  8. Manobras de reposicionamento no tratamento da vertigem paroxística posicional benigna Treatment of benign paroxysmal positional vertigo with repositioning manevers

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    Roberto A. Maia

    2001-09-01

    Full Text Available Introdução: Vertigem paroxística posicional benigna (VPPB é uma das mais freqüentes patologias do sistema vestibular. Caracteriza-se clinicamente pela presença de episódios recorrentes de tonturas rotatórias, tipicamente desencadeados por determinados movimentos cefálicos, realizados pelo paciente. A confirmação diagnóstica é obtida exclusivamente pela manobra de Dix-Hallpike. Nessa manobra, observa-se sistematicamente o desencadeamento de nistagmo. Forma de estudo: Prospectivo clínico não randomizado. Material e método: No total, sete pacientes com diagnóstico clínico de VPPB são submetidos a tratamento pela manobra de reposicionamento de Epley. Resultado: Desses sete pacientes avaliados, cinco apresentaram ótima recuperação; dois, com resultado bom; e um, com mau resultado; para este último caso, outras formas de tratamento são apresentadas. Conclusão: O exame otoneurológico, realizado em todos os pacientes, demonstrou ser de interessante valor prognóstico quanto ao resultado do tratamento proposto. A manobra de reposicionamento de Epley demonstrou ser um método de tratamento da VPPB simples, e eficaz na grande maioria dos pacientes aqui relatados.Introduction: Benign Paroxysmal Positional Vertigo (BPPV is among the most common vestibular disorders. It is characterized by recurrent episodes of vertigo induced by changes in head position. The condition is readly diagnosed by performing the Dix-Hallpike maneuver. Nystagmus is always present by this way. Study design: Prospective results clinical not randomized. Material and method: A total of seven patients diagnosed with BPPV received the repositioning maneuver of Epley. Five out of seven patients had excellent recovery, two patients had good results and one had a bad result. For this last one different treatments are discussed. Conclusion: We performed otoneurological examination in all patients; this test seems to be an intersting prognosis method for seeking the

  9. Incidencia en España de la asbestosis y otras enfermedades pulmonares benignas debidas al amianto durante el período 1962-2010

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    Montserrat García Gómez

    2012-01-01

    Full Text Available Fundamentos: En España carecemos de una descripción completa de las enfermedades profesionales causadas por el amianto. El objetivo del presente trabajo esconocer la incidencia durante el período 1962-2010 de las asbestosis y otras enfermedades pulmonares benignas por amianto reconocidas como profesionales y su distribución por sectores, ocupación, sexo y ámbito geográfico. Métodos: El número de casos se obtuvo de las Memorias del INP (años 1962 a 1975, de la Estadística del Ministerio de Trabajo y las Memorias del Servicio de Higiene y Seguridad en el Trabajo (1976 a 1981 y de los Anuarios de Estadísticas Laborales a partir de 1982. Se obtuvieron tasas de incidencia específicas por actividad económica y ocupación. Se estudió la tendencia temporal del número de enfermedades a estudio, así como su distribución geográfica por Comunidad Autónoma y provincia. Resultados: Desde 1963 hasta 2010 se reconocieron 815 asbestosis y 46 afecciones fibrosantes de pleura y pericardio. La incidencia media anual de asbestosis fue 0,20 por 100.000 personas asalariadas (0,31 en el año 1990 y 0,40 en 2010. De 1990 a 2001 el sector del fibrocemento acumuló 189 casos de asbestosis, el naval 173, la construcción 49 y la metalurgia 35. Por ocupación, los operadores de maquinas fijas presentaron 114 casos, los moldeadores, soldadores, chapistas y montadores de estructuras metálicas 88 casos y los pintores, fontaneros e instaladores de tuberías 59. Las Comunidades Autónomas con más casos fueron la Valenciana (106, Galicia (86, Andalucía (82, Cataluña (75, Madrid (58 y País Vasco (41. Conclusiones: Las tasas de incidencia y la tendencia de asbestosis profesionales en España pueden estar evidenciando el infrareconocimiento del origen profesional de estas enfermedades en nuestro país. Los sectores más afectados fueron el del fibrocemento y el naval y la incidencia más alta se dió en la Comunidad Valenciana.

  10. Active head rotation in benign positional paroxysmal vertigo Da rotação cefálica ativa na vertigem posicional paroxística benigna

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    Fernando Freitas Ganança

    2009-08-01

    Full Text Available Benign Positional Paroxysmal Vertigo (BPPV is one of the most common vestibular diseases and the active head rotation test one of the most modern methods of vestibular function assessment. AIM: this study aims to verify if the active head rotation test may reveal signs of horizontal and/or vertical vestibulo-ocular reflex dysfunction in vertigo patients suspected for BPPV. STUDY DESIGN: retrospective series study. MATERIALS AND METHOD: Neurotological evaluation including computerized electronystagmography and active head rotation on the horizontal and vertical axes were conducted in 100 patients suspected for BPPV patients. Results: Isolated or associated abnormalities of the horizontal and/or vertical vestibulo-ocular reflex gain, phase and symmetry were indicative of vestibular involvement and found in 77.0% of the BPPV patients. CONCLUSION: the active head rotation test revealed horizontal and/or vertical vestibulo-ocular reflex dysfunctions in a relevant number of BPPV patients.A vertigem posicional paroxística benigna (VPPB corresponde a uma das vestibulopatias mais comuns e a rotação cefálica ativa um dos métodos mais modernos de avaliação da função vestibular. OBJETIVO: O objetivo desta pesquisa foi verificar se a prova de rotação cefálica ativa pode revelar sinais de disfunção do reflexo vestíbulo-ocular horizontal e/ou vertical em pacientes vertiginosos com hipótese diagnóstica de VPPB. DESENHO DO ESTUDO: Estudo de série retrospectivo. MATERIAL E MÉTODO: Uma avaliação otoneurológica incluindo a eletronistagmografia computadorizada e a prova de rotação cefálica ativa, no plano horizontal e vertical foi conduzida em 100 pacientes com hipótese diagnóstica de VPPB. Resultados: Alterações isoladas ou associadas de ganho, fase e assimetria do reflexo vestíbulo-ocular horizontal e/ou vertical, foram os achados indicativos de comprometimento vestibular em 77,0% dos casos de VPPB. CONCLUSÃO: A prova de rota

  11. Benign paroxysmal positional vertigo recurrence and persistence Recorrência e persistência da vertigem posicional paroxística benigna

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    Ricardo S Dorigueto

    2009-08-01

    Full Text Available Benign paroxysmal positional vertigo (BPPV is one of the most common vestibular disorders. AIM: To study the recurrence and persistence of BPPV in patients treated with canalith repositioning maneuvers (CRM during the period of one year. STUDY DESIGN: longitudinal contemporary cohort series. MATERIALS AND METHODS: One hundred patients with BPPV were followed up during 12 months after a treatment with CRM. Patients were classified according to disease evolution. Aquatic physiotherapy for vestibular rehabilitation (APVR protocol was applied in cases of persistent BPPV. RESULTS: After CRM, 96% of the patients were free from BPPV's typical nystagmus and dizziness. During the follow up period of 1 year, 26 patients returned with typical BPPV nystagmus and vertigo. Nystagmus and vertigo were persistent in 4% of the patients. Persistent BPPV presented improvement when submitted to APVR. Conclusion: During the period of one year, BPPV was not recurrent in 70% of the patients, recurrent in 26% and persistent in 4%.A vertigem posicional paroxística benigna (VPPB é das vestibulopatias mais comuns. OBJETIVO: Verificar a recorrência e a persistência da VPPB no período de um ano em pacientes que foram tratados com manobras de reposicionamento de estatocônios (MRE. FORMA DE ESTUDO: coorte contemporânea longitudinal. MATERIAL E MÉTODO: Cem pacientes com VPPB foram acompanhados durante 12 meses após o tratamento com MRE. Os pacientes foram classificados de acordo com a evolução da doença no período de um ano. O protocolo de fisioterapia aquática para reabilitação vestibular (FARV foi aplicado nos pacientes com VPPB persistente. RESULTADOS: Após as MRE, 96% dos pacientes aboliram o nistagmo e a vertigem de posicionamento. Destes pacientes, 26 apresentaram recorrência da VPPB, no período de um ano. Em 4% dos pacientes, a VPPB foi persistente. Os pacientes com VPPB persistente apresentaram melhora clínica após a realização da FARV. CONCLUS

  12. Resultados do Balance Rehabilitation Unit na Vertigem Posicional Paroxística Benigna Results from the Balance Rehabilitation Unit in Benign Paroxysmal Positional Vertigo

    Directory of Open Access Journals (Sweden)

    Cristiane Akemi Kasse

    2010-10-01

    Full Text Available A posturografia é um instrumento útil e novo para o estudo da influência das doenças vestibulares no equilíbrio corporal. OBJETIVO: Comparar os resultados da posturografia estática do Balance Rehabilitation Unit (BRU em idosos com Vertigem Postural Paroxística Benigna (VPPB pré e pós a manobra de Epley. MATERIAL E MÉTODO: Estudo prospectivo de 20 pacientes idosos com diagnóstico de VPPB. Os pacientes foram submetidos à posturografia estática do BRU, e o limite de estabilidade (LE e a área de elipse foram medidos. Aplicou-se também o questionário "Dizziness Handicap Inventory" versão brasileira (DHI para verificar a eficácia do tratamento. RESULTADOS: 80% pacientes eram do gênero feminino, com a média etária de 68,15 anos. Após a manobra, o LE aumentou significantemente (p=0,001. A área de elipse nas condições de conflitos sensoriais, visuais e vestibulares da BRU (condições 2,7,8,9 e o escore do DHI diminuíram significantemente (pPosturography is a useful new tool to study the influence of vestibular diseases on balance. AIM: to compare the results from the Balance Rehabilitation Unit (BRU static posturography in elderly patients with Benign Paroxysmal Positional Vertigo (BPPV, before and after Epley's maneuver. MATERIALS AND METHODS: a prospective study of 20 elderly patients with a diagnosis of BPPV. The patients underwent static posturography and the limit of stability (LE and ellipse area were measured. We also applied the Dizziness Handicap Inventory (DHI questionnaire to study treatment effectiveness. RESULTS: 80% were females, with a mean age of 68.15 years. After the maneuver, the LE increased significantly (p=0.001. The elliptical area of somatosensory, visual and vestibular conflicts (2,7,8,9 situations in BRU and the DHI scores decreased significantly (p<0.05 after treatment. CONCLUSION: the study suggests that elderly patients with BPPV may present static postural control impairment and that the maneuver

  13. Estado de mal epiléptico en pediatría

    Directory of Open Access Journals (Sweden)

    Jorge Malagón Valdez

    2013-09-01

    Full Text Available El estado de mal epiléptico es una emergencia médica en la cual se presentan crisis epilépticas por 30 minutos o más de actividad continua, o bien dos o más crisis consecutivas sin recuperación completa de la conciencia entre las mismas. Actualmente se considera que una crisis epiléptica convulsiva o no, que dure más de 5 minuto se deberá considerar un estado de mal epiléptico. Se han utilizado diversos fármacos para el tratamiento de esta patología y sus secuelas. Hay un consenso generalizado en que se debe realizar un manejo agresivo para disminuir su morbi-mortalidad, sin olvidarse que la causa del estado de mal es importante para su manejo, control y sus secuelas.

  14. El Mal y la subjetivación política

    Directory of Open Access Journals (Sweden)

    Jairo H. Gómez-Esteban

    2014-05-01

    Full Text Available El propósito de este ensayo es retomar el problema del Mal en los diversos modos de subjetivación política. Sus objetivos se sitúan en denunciar cómo las perspectivas afirmativas de la subjetividad escamotean el papel que el Mal cumple en los procesos de subjetivación, y señalar las implicaciones que tiene el Mal en la investigación de subjetividades políticas en un país con un conflicto armado inveterado que mantiene uno de los índices de desigualdad e injusticia social más alto, y cuyos investigadores e investigadoras asumen que la subjetivación política se encuentra únicamente en la participación y la democracia, en la autorregulación y la autonomía, en el reconocimiento y la identidad.

  15. Estudo do uso de midazolam em crianças com estado de mal epileptico

    OpenAIRE

    Lohr Junior, Alfredo

    2013-01-01

    Resumo: O presente estudo teve o propósito de reavaliar o uso do midazolam em crianças com estado de mal epiléptico refratário. Foram avaliadas 50 crianças com estado de mal epiléptico, internadas na unidade de terapia intensiva do Hospital Infantil Pequeno Príncipe - Curitiba, Paraná, Brasil. O estudo foi caracterizado por dois grupos de pacientes, Grupo A - Midazolam (n=24) prospectivo, e o Grupo B - Thiopental (n=26) histórico. O Grupo Midazolam compôs-se por crianças com o diagnostico cli...

  16. Spatio-temporal analysis of human electroencephalograms: Petit-mal epilepsy

    Science.gov (United States)

    Friedrich, R.; Uhl, C.

    An analysis of multigrid electroencephalograms (EEG) derived from two different persons suffering from petit-mal epilepsy is performed. Using a previously devised method for analyzing spatio-temporal patterns (Uhl, et al., Z. Phys. B 92 (1993) 211-219), we find a suitable mode decomposition of the EEG. Additionally, we are able to extract a three-dimensional dynamical system which describes the dynamics of the patterns as a kind of mode interaction. We show that the spike-wave behavior characteristic for petit-mal epilepsy arising in the dynamical system is related with Sil'nikov-type behavior of the mode dynamics.

  17. Minilaparoscopic-assisted transvaginal approach in benign liver lesions Abordaje transvaginal asistido por minilaparoscopia en lesiones benignas del hígado

    Directory of Open Access Journals (Sweden)

    R. Castro-Pérez

    2010-06-01

    benignas del hígado tratadas quirúrgicamente mediante el abordaje transvaginal asistido por minilaparoscopia. Pacientes y métodos: mujeres de 44 y 45 años de edad, respectivamente. La paciente 1 presentaba un pequeño tumor de 1,2 cm de Ø, en el lóbulo izquierdo del hígado. En su preoperatorio no se logró precisar su etiología y se decidió extirparlo quirúrgicamente. La paciente 2 presentaba un quiste simple del hígado muy sintomático de 8 cm de Ø situado en el subsegmento VI, se negó a realizarse el tratamiento esclerosante por vía percutánea, por lo que se recomendó el tratamiento quirúrgico. Se les ofreció a ambas realizar la intervención mediante cirugía laparoscópica o el abordaje transvaginal, aceptando este último. El neumoperitoneo se realizó con presión de 15 mmHg. Se colocaron 2 minipuertos en abdomen, uno en región umbilical de 5 mm Ø y el otro de 3 mm Ø en el sitio más próximo a la lesión. Con visión directa se colocó 1 trocar en la pared posterior del fondo del saco vaginal de 11 mm Ø para el paso de un endoscopio rígido. En la paciente 1 se utilizó este mismo orificio para, adyacente al trocar, introducir un disector largo. En la paciente 2 se introdujo un segundo trocar de 5 mm Ø para el paso de instrumentos de trabajo. Ambos especímenes fueron extraídos a través de la vagina en bolsas extractoras. Se registró el tiempo quirúrgico, necesidad de analgésicos y complicaciones postoperatorias. Resultados: los tiempos quirúrgicos fueron de 51 y 73 minutos, respectivamente. La paciente operada del quiste hepático requirió administración de analgésico postoperatorio. El alta hospitalaria fue dada antes de las 24 horas de la intervención. No se han presentado complicaciones postoperatorias relacionadas con el proceder después de un seguimiento mínimo de 6 meses. Conclusiones: con el empleo de instrumentos rígidos, fue posible realizar el tratamiento quirúrgico de dos lesiones benignas del hígado, de poca

  18. Le mal de Pott: à propos de 82 cas

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    Badr Fedoul

    2011-03-01

    Full Text Available Nous rapportant dans cette étude, les résultats de l’expérience du service de neurochirurgie du CHU Hassan II de Fès dans la prise en charge du mal de pott dans la région de Fès. Il s’agit d’une étude rétrospective de quatre-vingt-deux cas; étalée sur une période de cinq ans (janvier 2002 au décembre 2006. L’objectif de ce travail était d’illustrer les différents aspects épidémiologiques, diagnostiques et thérapeutiques de la localisation vertébrale de la tuberculose dans notre pratique. L'âge moyen de nos patients était de 43,1 ans, avec une légère prédominance féminine (53,82%. La durée d'évolution de la maladie était longue (dix mois en moyenne; ceci est expliquée par la symptomatologie initiale insidieuse faite de rachialgies (98,78% et une admission des patients au stade de complications neurologiques (41,46%. La radiographie standard était réalisée chez tous nos patients, et complétée par la TDM dans 86.58% des cas ce qui a permis de déceler la prédominance de l'atteinte dorsale et lombaire. L'IRM est l'examen de choix, elle était demandée chez tous les malades déficitaires (37,8%.Tous nos patients ont bénéficié d'un traitement antibacillaire associé à une immobilisation du foyer pottique. Une décompression par voie antérieure était réalisée chez 29 patients (35,36 %; alors que la laminectomie n'était pratiquée que chez 5 patients (6.09 %, tandis que l'évacuation de l'abcès de psoas était réalisée chez 25 patients (30,48 %. Le diagnostic de certitude histologique était posé dans 51 cas (62,19%. Les meilleurs résultats étaient obtenus chez les malades opérés par voie antérieure, 26 cas (89,65% de récupération totale et 3 cas (10,34% partielle. L'évolution vers la consolidation et la fusion vertébrale était la règle chez tous nos malades et ceci au bout de 4 à 18 mois après le traitement.

  19. Rising Mal-Employment and the Great Recession: The Growing Disconnection between Recent College Graduates and the College Labor Market

    Science.gov (United States)

    Fogg, Neeta P.; Harrington, Paul E.

    2011-01-01

    This article looks at the phenomenon of mal-employment among college graduates in the United States, beginning with an overview of labor-market trends and the effects of the Great Recession on the job-market experiences of young people, including recent college graduates. It then defines "mal-employment" and examines its incidence over time. The…

  20. Maturity and storage influence on the apple (Malus domestica) allergen Mal d 3, a nonspecific lipid transfer protein

    NARCIS (Netherlands)

    A.I. Sancho; R. Foxall; N.M. Rigby; T. Browne; L. Zuidmeer; R. van Ree; K.W. Waldron; E.N.C. Mills

    2006-01-01

    Consumption of apples can provoke severe allergic reactions, in susceptible individuals, due to the presence of the allergen Mal d 3, a nonspecific lipid transfer protein, found largely in the fruit skin. Levels of Mal d 3 were determined in peel as a function of apple cultivar, position of the frui

  1. Malformações do sistema nervoso central e malformações associadas diagnosticadas pela ultrassonografia obstétrica

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    Marcela Leonardo Barros

    2012-12-01

    Full Text Available OBJETIVO: Identificar a prevalência de malformações congênitas do sistema nervoso central (SNC e malformações associadas diagnosticadas pela ultrassonografia obstétrica. MATERIAIS E MÉTODOS: Estudo observacional, transversal, descritivo, em instituição de referência para gestações de alto risco. RESULTADOS: Malformações congênitas do SNC estiveram presentes sem outras malformações associadas em 65,78%, com a distribuição: hidrocefalia (37,5%, mielomeningocele (15%, encefalocele (12,5%, agenesia de corpo caloso (12,5%, anencefalia (12,5%, holoprosencefalia (7,5%, Dandy-Walker (7,5%, Arnold-Chiari (5,0%, hidranencefalia (5,0%, meningocele (5,0%, cisto aracnoideo (2,5%. Malformações congênitas de outros sistemas estiveram associadas às do SNC: craniofacial (73,9%, ortopédica (65,2%, cardiovascular (34,8%, geniturinária (30,4%, gastrintestinal (30,4%, respiratória (8,7%, sindrômica (8,7, oftalmológica (4,3%. A sensibilidade ultrassonográfica no estudo de malformações fetais do SNC foi 79,4%. A taxa de falso-negativos foi 20,5%. Dentre as limitações quantificáveis destaca-se o oligodrâmnio, presente em 25% dos falso-negativos. CONCLUSÃO: A ultrassonografia obstétrica possui boa sensibilidade no rastreio de malformações fetais do SNC, em especial com o aperfeiçoamento constante e domínio na utilização de métodos especializados, como o Doppler e a ultrassonografia volumétrica (3D/4D, contribuindo para firmar-se como modalidade de escolha nesta rotina. Complementar ao método, a ressonância magnética pode vir a fornecer subsídios para uma ainda melhor assistência perinatal.

  2. Optimización de los protocolos de hiperestimulación ovárica controlada para FIV/ICSI en pacientes diagnosticadas de síndrome de ovarios poliquísticos

    OpenAIRE

    Gil Raga, Fernando

    2010-01-01

    Objetivo principal Comprobar la eficacia y seguridad de la estimulación con FSHr bajo bloqueo gonadotropo hipofisario por administración de una antagonista de GnRH (Ganirelix) iniciando ésta al comienzo del ciclo menstrual, simultáneamente a la administración de FSHr en un grupo de estudio formado por mujeres estériles diagnosticadas de SOP. Material y Métodos Diseño: Estudio longitudinal prospectivo y comparativo, no randomizado, de 3 años de duración. Muestra: 278 pacientes di...

  3. Efecto de un programa de ejercicio físico acuático en la enfermedad de Parkinson: Estudio piloto sobre mujeres diagnosticadas con un grado leve o moderado

    OpenAIRE

    Cancela Carral, José María; C. Ayán; Nascimento, C; Rodríguez, P

    2013-01-01

    Los beneficios del ejercicio físico en personas con enfermedad de Parkinson han sido ampliamente estudiados. Sin embargo, poco se sabe acerca de los efectos del ejercicio acuático en esta población. El propósito de este estudio fue determinar si las mujeres, diagnosticadas de la enfermedad de Parkinson en un grado de leve a moderado, pueden tomar parte y beneficiarse de un programa de ejercicio físico en agua. Doce mujeres con enfermedad de Parkinson (Hoehm y Yahr, rango:1-3), sin demencia y ...

  4. Glucose and maltose metabolism in MIG1-disrupted and MAL-constitutive strains of Saccharomyces cerevisiae

    DEFF Research Database (Denmark)

    Klein, Christopher; Olsson, Lisbeth; Rønnow, B;

    1997-01-01

    The alleviation of glucose control of maltose metabolism brought about by MIG1 disruption was compared to that by MAL overexpression in a haploid Saccharomyces cerevisiae strain. The sugar consumption profiles during cultivation of the wild type, single transformants and a double transformant in ...

  5. Malária por Plasmodium falciparum: estudos proteômicos

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    Rodrigo Siqueira-Batista

    2012-12-01

    Full Text Available A despeito dos avanços no tratamento e das campanhas de prevenção e de controle da malária nos distintos continentes nos quais a moléstia grassa, a entidade mórbida permanece com significativa relevância no mundo contemporâneo. O Plasmodium falciparum é o grande responsável pela malária grave, caracterizada por distúrbios em diferentes órgãos e sistemas, com possibilidade de evolução ao óbito. Embora incipientes, os estudos proteômicos na malária têm trazido boas perspectivas para melhor compreensão dos aspectos biológicos do Plasmodium, assim como dos mecanismos fisiopatológicos, diagnósticos, terapêuticos e profiláticos da enfermidade. Desse modo, o objetivo do presente artigo é apresentar uma breve revisão das aplicações da análise proteômica na malária por P. falciparum.

  6. The Analysis of Prefixes-Taking mal-and mis-As Examples

    Institute of Scientific and Technical Information of China (English)

    CAO Ji-xin

    2015-01-01

    The present paper is aimed to testify that the richness and abundance of English vocabulary is closely related to prefix⁃es. Through the analysis of prefixes such as mal-and mis-, a better understanding of word formation from the perspective of se⁃mantic factors and functional factors as well as morphology factors will be obtained.

  7. Heterogeneity in the Properties of Mutant SLURP1 Proteins in Mal de Meleda

    DEFF Research Database (Denmark)

    Adeyo, O; Oberer, M; Ploug, M;

    2015-01-01

    Genetic defects in SLURP1, a "lymphocyte antigen 6" (Ly6)-like protein, cause mal de Meleda, a palmoplantar keratoderma (PPK). The hallmark of Ly6 proteins is an 80-amino acid domain containing 10 cysteines, all arranged in a characteristic spacing pattern and all disulfide-bonded, creating a three...

  8. SLURP1 is a late marker of epidermal differentiation and is absent in Mal de Meleda

    DEFF Research Database (Denmark)

    Favre, Bertrand; Plantard, Laure; Aeschbach, Lorène;

    2007-01-01

    SLURP1 is a secreted member of the LY6/PLAUR protein family. Mutations in the SLURP1 gene are the cause of Mal de Meleda (MDM), a rare autosomal recessive genetic disease, characterized by inflammatory palmoplantar keratoderma. In this study, we have analyzed the expression of SLURP1 in normal...

  9. Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de Meleda

    DEFF Research Database (Denmark)

    Chimienti, Fabrice; Hogg, Ronald C; Plantard, Laure;

    2003-01-01

    Mal de Meleda is an autosomal recessive inflammatory and keratotic palmoplantar skin disorder due to mutations in the ARS B gene, encoding for SLURP-1 (secreted mammalian Ly-6/uPAR-related protein 1). SLURP-1 belongs to the Ly-6/uPAR superfamily of receptor and secreted proteins, which participate...

  10. MAL Is a Regulator of the Recruitment of Myelin Protein PLP to Membrane Microdomains

    NARCIS (Netherlands)

    Bijlard, Marjolein; de Jonge, Jenny C.; Klunder, Bert; Nomden, Anita; Hoekstra, Dick; Baron, Wia

    2016-01-01

    In oligodendrocytes (OLGs), an indirect, transcytotic pathway is mediating transport of de novo synthesized PLP, a major myelin specific protein, from the apical-like plasma membrane to the specialized basolateral-like myelin membrane to prevent its premature compaction. MAL is a well-known regulato

  11. Tratamento conservador das estenoses benignas do esôfago através de dilatações. Análise de 500 casos

    Directory of Open Access Journals (Sweden)

    ANDREOLLO N.A.

    2001-01-01

    Full Text Available As estenoses benignas do esôfago (EBE são complicações muito freqüentes, resultado de várias etiologias, a saber: refluxo gastro-esofágico, ingestão de agentes corrosivos, pós-cirurgias do esôfago, pós-radioterapia no tórax, pós-escleroterapia endoscópica de varizes do esôfago, ingestão de medicamentos, uso prolongado de cateter nasogástrico, compressão extrínseca e membranas esofágicas congênitas. As dilatações esofágicas são recomendadas no tratamento dessa complicação, empregando dilatadores de vários tipos e diâmetros, facilitando ao doente a ingestão alimentar. OBJETIVOS: Avaliação dos resultados e vantagens do tratamento conservador das EBE através de dilatações esofágicas realizadas ambulatorialmente com auxílio da endoscopia digestiva flexível. MÉTODOS: No período de 1981 a 1999 foram tratados, conservadoramente e seguidos no Gastrocentro -- UNICAMP, 500 doentes com EBE, através de um Programa de Dilatações Esofágicas instituído para cada caso. A maioria era do sexo masculino (59,2% e a faixa etária mais acometida encontra-se entre 31 anos e 60 anos, compreendendo 52,8% dos pacientes em estudo. As estenoses mais prevalentes foram as estenoses pépticas (30,4%, cáusticas (23,6%, de anastomoses (23,2%, por megaesôfago (8,0% e por uso prolongado de cateter nasogástrico (6,4%, perfazendo um total de 91,6% das EBE. Quanto ao número de procedimentos, 94,2% dos casos foram submetidos a no máximo 25 dilatações do esôfago. Em 95,6% deles foram utilizados dilatadores com diâmetro entre 10,5 mm e 16,0 mm. A duração do tratamento foi até 24 meses em 76,2% dos casos. Perfurações esofágicas ocorreram em seis doentes (1,2%, sem mortalidade. RESULTADOS: Foram considerados bons em 76,2%, regulares em 18,2% e maus em 5,6% dos doentes. O sucesso do tratamento variou conforme a etiologia da estenose, ocorrendo bons resultados em 81,0% das estenoses pépticas, em 66,1% das estenoses cáusticas e em

  12. Impact of sulfur and vitamin C on the allergenicity of Mal d 2 from apple (Malus domestica).

    Science.gov (United States)

    Marzban, Gorji; Kinaciyan, Tamar; Maghuly, Fatemeh; Brunner, Richard; Gruber, Clemens; Hahn, Rainer; Jensen-Jarolim, Erika; Laimer, Margit

    2014-07-30

    Mal d 2 is a minor allergen from apple which shows a high conformational stability due to its eight conserved disulfide bridges. Chemical reduction of disulfide bridges and linearization of Mal d 2 lead to enhanced IgE reactivity in vitro and indicate a higher potential for allergenicity. Since food preservatives such as sulfur and vitamin C are reducing and denaturing agents, their influence on Mal d 2 allergenicity was verified by simulated food processing conditions. The immunoreactivity of purified Mal d 2 was investigated after different treatments in vitro and in vivo using IgG/IgE Western blotting, mediator-releasing cell assay, and skin prick and oral smear tests. The conformational changes of Mal d 2 upon addition of 1% and 5% vitamin C were also monitored by attenuated total reflectance Fourier transform infrared spectroscopy. The results show no positive skin and oral smear test reactivity to native, heated, or vitamin C-treated purified Mal d 2. Furthermore, the results confirm that sulfur in combination with heat treatment can influence the structural integrity and thus the allergenicity of Mal d 2, while vitamin C is too weak as a reducing agent to change allergenicity.

  13. Dermatomiosite recém-diagnosticada em idosos como preditiva de malignidade Newly diagnosed dermatomyositis in the elderly as predictor of malignancy

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    Fernando Henrique Carlos de Souza

    2012-10-01

    Full Text Available OBJETIVO: Os sintomas da dermatomiosite (DM podem ser um indício da existência de um câncer oculto. Melhorar a detecção precoce é essencial, porém não há estudos avaliando em curto prazo os fatores preditivos para a doença. MÉTODO: Estudo retrospectivo, monocêntrico, incluindo pacientes com DM definida (pelo menos quatro dos cinco critérios de Bohan e Peter, 1975, no período entre 1991 e 2011. A presença de malignidade foi limitada a um período de até 12 meses após o diagnóstico da doença. RESULTADOS: Houve 12 casos de neoplasias em 139 pacientes (pele, trato gastrintestinal, próstata, tireoide, mama, pulmão e trato geniturinário. Os pacientes com neoplasia tiveram maior média de idade que os controles (56,8 ± 15,7 vs. 40,3 ± 13,1 anos, respectivamente, P = 0,004; odds ratio 1,09; intervalo de confiança de 95%: 1,04-1,14. Não foram observadas diferenças estatísticas em relação a gênero, etnia, frequência de sintomas constitucionais, envolvimento de órgãos e sistemas e/ou alterações laboratoriais. CONCLUSÃO: Na DM recém-diagnosticada, a idade tardia ao diagnóstico foi um fator preditivo de malignidade.OBJECTIVE: Dermatomyositis (DM symptoms may be a clue to the existence of a hidden cancer. Enhancing early detection is essential, but there are no studies evaluating short-term predictive factors in this disease. METHODS: This is a singlecenter retrospective study, including patients diagnosed with DM meeting at least four of the five Bohan and Peter's criteria (1975, from 1991 to 2011. This study assessed malignancies occurring in up to 12 months after the diagnosis of DM. RESULTS: Neoplasm was found in 12 out of 139 patients (skin, gastrointestinal tract, prostate, thyroid, breast, lungs, and genitourinary tract. Patients with neoplasm had a higher mean age than controls (56.8 ± 15.7 vs. 40.3 ± 13.1 years, respectively, P = 0.004, odds ratio 1.09; 95% confidence interval: 1.04-1.14. No statistical

  14. Agentes etiológicos de onicomicosis diagnosticadas en el laboratorio de micología médica de la Universidad de Costa Rica

    Directory of Open Access Journals (Sweden)

    Ingrid Salas-Campos

    2012-06-01

    Full Text Available Justificación y objetivos: Entre las onicodistrofias, la onicomicosis es la afección más frecuente. Esta infección no solo representa un problema estético para el paciente, sino que puede afectar sus actividades diarias. Para el dermatólogo se hace indispensable realizar el diagnóstico diferencial, por lo que el laboratorio de micología médica es de gran ayuda para este propósito. En cuanto a los agentes etiológicos incriminados, los dermatofitos son los más frecuentes; sin embargo, otros hongos filamentosos no dermatofitos se han aislado, cuya sensibilidad a los antimicóticos es menor. En este trabajo se estudió la frecuencia de las onicomicosis diagnosticadas en el laboratorio de Micología Médica de la UCR durante cuatro años, según edad y sexo de los pacientes, así como agentes etiológicos identificados. Métodos: Se incluyó a todos los pacientes que solicitaron el servicio de acción social que brinda la sección de Micología Médica, Facultad de Microbiología, Universidad de Costa Rica, entre enero del 2007 a diciembre del 2010 y que presentaban alteraciones ungueales sospechosas de onicomicosis. Se registró la edad y sexo de los pacientes y las muestras se procesaron por examen directo y cultivo. Resultados: Se procesaron 431 muestras de uñas, el 85,4% eran de pie y el 14,6% de mano, la edad promedio de los pacientes fue de 49 años, el 64% eran mujeres y el 36% eran hombres. En el 73,4% se diagnosticó onicomicosis, ya sea por examen directo positivo y cultivo positivo, o solo con el examen directo, de las cuales 89,4% eran uñas de pie y 10,6% uñas de manos. De las uñas de los pies se aisló más frecuentemente Trichophyton rubrum y en segundo lugar Fusarium spp. En uñas de manos C. albicans fue el agente etiológico más frecuente. Conclusión: En el diagnóstico de las onicomicosis se debe considerar tanto la clínica como los hallazgos de laboratorio. En la población estudiada se identificaron dermatofitos

  15. SmartMal: a service-oriented behavioral malware detection framework for mobile devices.

    Science.gov (United States)

    Wang, Chao; Wu, Zhizhong; Li, Xi; Zhou, Xuehai; Wang, Aili; Hung, Patrick C K

    2014-01-01

    This paper presents SmartMal--a novel service-oriented behavioral malware detection framework for vehicular and mobile devices. The highlight of SmartMal is to introduce service-oriented architecture (SOA) concepts and behavior analysis into the malware detection paradigms. The proposed framework relies on client-server architecture, the client continuously extracts various features and transfers them to the server, and the server's main task is to detect anomalies using state-of-art detection algorithms. Multiple distributed servers simultaneously analyze the feature vector using various detectors and information fusion is used to concatenate the results of detectors. We also propose a cycle-based statistical approach for mobile device anomaly detection. We accomplish this by analyzing the users' regular usage patterns. Empirical results suggest that the proposed framework and novel anomaly detection algorithm are highly effective in detecting malware on Android devices. PMID:25165729

  16. Une localisation exceptionnelle de la tuberculose vertébrale Mal de Pott sous-occipital

    Science.gov (United States)

    Yahyaoui, Sana; Majdoub, Senda; Zaghouani, Houneida; Fradj, Hosni Ben; Bakir, Dejla; Bouajina, Elyes; Kraiem, Chakib

    2013-01-01

    Le mal de Pott est la forme la plus commune de la tuberculose osseuse touchant essentiellement le rachis dorso-lombaire. La localisation sous-occipitale reste exceptionnelle. Le diagnostic de cette entité est le plus souvent tardif ce qui expose à des complications graves. Les radiographies standard ne sont parlantes qu’à un stade tardif de la maladie, d'où l'intérêt de l'imagerie moderne notamment la tomodensitométrie (TDM) et l'imagerie par résonance magnétique (IRM) qui permettent un diagnostic précoce. Nous rapportons un nouveau cas de tuberculose sous-occipitale. Le diagnostic était posé sur l'imagerie en coupe et confirmé histologiquement à la biopsie transorale. Sont rappelés les aspects en imagerie de cette localisation particulière du mal de Pott. PMID:23819005

  17. Structure of the conserved hypothetical protein MAL13P1.257 from Plasmodium falciparum

    International Nuclear Information System (INIS)

    The crystal structure of a conserved hypothetical protein, MAL13P1.257 from P. falciparum, has been determined at 2.17 Å resolution. The structure represents a new protein fold and is the first structural representative for Pfam sequence family PF05907. The structure of a conserved hypothetical protein, PlasmoDB sequence MAL13P1.257 from Plasmodium falciparum, Pfam sequence family PF05907, has been determined as part of the structural genomics effort of the Structural Genomics of Pathogenic Protozoa consortium. The structure was determined by multiple-wavelength anomalous dispersion at 2.17 Å resolution. The structure is almost entirely β-sheet; it consists of 15 β-strands and one short 310-helix and represents a new protein fold. The packing of the two monomers in the asymmetric unit indicates that the biological unit may be a dimer.

  18. SmartMal: a service-oriented behavioral malware detection framework for mobile devices.

    Science.gov (United States)

    Wang, Chao; Wu, Zhizhong; Li, Xi; Zhou, Xuehai; Wang, Aili; Hung, Patrick C K

    2014-01-01

    This paper presents SmartMal--a novel service-oriented behavioral malware detection framework for vehicular and mobile devices. The highlight of SmartMal is to introduce service-oriented architecture (SOA) concepts and behavior analysis into the malware detection paradigms. The proposed framework relies on client-server architecture, the client continuously extracts various features and transfers them to the server, and the server's main task is to detect anomalies using state-of-art detection algorithms. Multiple distributed servers simultaneously analyze the feature vector using various detectors and information fusion is used to concatenate the results of detectors. We also propose a cycle-based statistical approach for mobile device anomaly detection. We accomplish this by analyzing the users' regular usage patterns. Empirical results suggest that the proposed framework and novel anomaly detection algorithm are highly effective in detecting malware on Android devices.

  19. [Eugen Helimski, Urlike Kahrs. Nordselkupisches Wörterbuch von F. G. Mal'cev (1903)] / Ago Künnap

    Index Scriptorium Estoniae

    Künnap, Ago, 1941-

    2003-01-01

    Raamatust: Helimski, Eugen, Kahrs, Urlike. Nordselkupisches Wörterbuch von F. G. Mal'cev (1903). Hamburg, 2001. (Hamburger Sibirische und Finnisch-Ugrische Materialen / Habent Sua Fata Manuscripts; 1)

  20. Disease Surveillance Methods Used in the 8-Site MAL-ED Cohort Study

    OpenAIRE

    Richard, Stephanie A.; Barrett, Leah J; Richard L. Guerrant; Checkley, William; Miller, Mark A.

    2014-01-01

    Describing the early life associations between infectious disease episodes and growth, cognitive development, and vaccine response in the first 2 years of life is one of the primary goals of the Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) cohort study. To collect high-resolution data during a critical early period of development, field staff visit each study participant at their house twice weekl...

  1. Antimyeloma Effects of the Heat Shock Protein 70 Molecular Chaperone Inhibitor MAL3-101

    Directory of Open Access Journals (Sweden)

    Marc J. Braunstein

    2011-01-01

    Full Text Available Multiple myeloma (MM is the second most common hematologic malignancy and remains incurable, primarily due to the treatment-refractory/resistant nature of the disease. A rational approach to this compelling challenge is to develop new drugs that act synergistically with existing effective agents. This approach will reduce drug concentrations, avoid treatment resistance, and also improve treatment effectiveness by targeting new and nonredundant pathways in MM. Toward this goal, we examined the antimyeloma effects of MAL3-101, a member of a new class of non-ATP-site inhibitors of the heat shock protein (Hsp 70 molecular chaperone. We discovered that MAL3-101 exhibited antimyeloma effects on MM cell lines in vitro and in vivo in a xenograft plasmacytoma model, as well as on primary tumor cells and bone marrow endothelial cells from myeloma patients. In combination with a proteasome inhibitor, MAL3-101 significantly potentiated the in vitro and in vivo antimyeloma effects. These data support a preclinical rationale for small molecule inhibition of Hsp70 function, either alone or in combination with other agents, as an effective therapeutic strategy for MM.

  2. Integrating Electrodermal Biofeedback into the Treatment of Grand-Mal Seizures

    Directory of Open Access Journals (Sweden)

    Tullio Michele Scrimali

    2015-05-01

    Full Text Available Electrodermal activity and electrodermal biofeedback, when integrated into pharmacologic treatments, are promising methods for grand mal seizures. They can be used to monitor the patient arousal and help the patient learn some new strategies for better coping with stress and anxiety. Our proposed method can possibly reduce the number of crises for patients who are dependent on pharmacologic therapy and can also improve their quality of life. This article describes the scientific background of electrodermal monitoring and electrodermal biofeedback for patients affected by grand mal seizures. In this study, we have reported a clinical case study. A patient is treated for two years with electrodermal biofeedback to augment pharmacologic treatments. The trial has been designed according to a n=1 case study research. Our results showed that our methods can achieve a significant reduction in grand mal seizures and sympathetic arousal. The patient in consideration was also relaxed and exhibited a greater competency in coping with stress. In addition, the patient’s sense of mastery and self-efficacy was enhanced.

  3. El Mal y la subjetivación política

    Directory of Open Access Journals (Sweden)

    Jairo H. Gómez-Esteban

    2014-01-01

    Full Text Available Doctor en Educación. Magíster en Sociología de la Educación. Psicólogo. Profesor Titular de la Universidad Distrital Francisco José de Caldas. Autor de diversos libros y artículos sobre pedagogía, educación política, jóvenes y problemas metodológicos de la investigación social. Miembro del grupo Vivencias. Autor de un libro de cuentos. Correo electrónico: El propósito de este ensayo es retomar el problema del Mal en los diversos modos de subjetivación política. Sus objetivos se sitúan en denunciar cómo las perspectivas afirmativas de la subjetividad escamotean el papel que el Mal cumple en los procesos de subjetivación, y señalar las implicaciones que tiene el Mal en la investigación de subjetividades políticas en un país con un conflicto armado inveterado que mantiene uno de los índices de desigualdad e injusticia social más alto, y cuyos investigadores e investigadoras asumen que la subjetivación política se encuentra únicamente en la participación y la democracia, en la autorregulación y la autonomía, en el reconocimiento y la identidad. @gmail.com

  4. CFD modelling of flow mal-distribution in an industrial ammonia oxidation reactor: A case study

    International Nuclear Information System (INIS)

    Ammonia oxidation reactor is widely used in nitric acid plant to cause the catalytic reaction between air and ammonia to produce nitrous gases. In this work, the flow distribution inside the ammonia oxidation reactor at Shiraz Petrochemical Complex (SPC) has been simulated using Computational Fluid Dynamics (CFD) code. The CFD results showed that the flow is non-uniformly distributed inside the reactor due to improper header design of the reactor. Measuring of the temperature distribution around the skin of the reactor has been carried out using thermograph. The thermograph experiment showed a considerable temperature difference between the left and right side of the reactor. It was found that the mal-distribution of the gas flow inside the reactor can directly affect the performance of the reactor. - Highlights: •A failure has been observed in an industrial ammonia oxidation reactor. •CFD code helps to simulate the flow inside the reactor. •The flow becomes non-uniformly distributed due to the reactor header mal-design. •The flow mal-distribution results in some drawbacks

  5. Enfermidades diagnosticadas em bezerros na região sul do Rio Grande do Sul Diseases diagnosed in calves in southern Rio Grande do Sul, Brazil

    Directory of Open Access Journals (Sweden)

    Nathalia D. Assis-Brasil

    2013-04-01

    Full Text Available O objetivo deste estudo foi relatar a frequência das enfermidades que ocorrem em bovinos até um ano de idade na área de influência do Laboratório Regional de Diagnóstico (LRD da Faculdade de Veterinária da Universidade Federal de Pelotas (UFPel estabelecendo os principais fatores epidemiológicos associados à ocorrência dessas enfermidades. Foram revisados os protocolos de necropsias realizadas e de materiais de bovinos até um ano de idade, encaminhados ao LRD/UFPel entre 2000 e 2011. Em 35,6% dos casos, os bezerros eram de raças leiteiras e em 33,98% eram animais de raças de corte, 18,3% dos bezerros não tinham raça definida e em 12,1% dos casos não constava a raça no protocolo de necropsia. Os sistemas mais afetados foram o sistema nervoso central (22,7%, o digestivo (18,6% e o respiratório (16,8%. Os diagnósticos foram divididos por faixa etária sendo que 88 bezerros tinham 1-90 dias de idade; 42 casos corresponderam a animais de 4-6 meses; 32 casos corresponderam a bezerros com 7-9 meses e 44 eram bezerros com 10-12 meses de idade. As enfermidades mais frequentemente diagnosticadas nos bezerros de 1-90 dias foram pneumonias, malformações e encefalites/meningoencefalites com 19,3%, 15,9% e 11,3% dos casos, respectivamente. Nos bezerros com 4-6 meses de idade, as pneumonias ocorreram em 16,5% dos casos e o carbúnculo sintomático e as enterites representaram 7,1% dos diagnósticos cada. Nos bezerros de 7-9 meses, as enfermidades mais frequentes foram pneumonias e tétano com 9,3% dos casos e babesiose e parasitoses gastrintestinais com 6,2% cada. Nos bezerros de 10-12 meses a infecção por BoHV-5 representou 13,6% dos casos e as pneumonias, a raiva e as parasitoses foram observadas em 9,% dos casos cada. Com base nos resultados deste trabalho pode-se concluir que as doenças infecciosas relacionadas ao sistema respiratório foram importantes causas de mortalidade em bezerros de todas as faixas etárias na área de influ

  6. MAL2 and tumor protein D52 (TPD52 are frequently overexpressed in ovarian carcinoma, but differentially associated with histological subtype and patient outcome

    Directory of Open Access Journals (Sweden)

    Fanayan Susan

    2010-09-01

    Full Text Available Abstract Background The four-transmembrane MAL2 protein is frequently overexpressed in breast carcinoma, and MAL2 overexpression is associated with gain of the corresponding locus at chromosome 8q24.12. Independent expression microarray studies predict MAL2 overexpression in ovarian carcinoma, but these had remained unconfirmed. MAL2 binds tumor protein D52 (TPD52, which is frequently overexpressed in ovarian carcinoma, but the clinical significance of MAL2 and TPD52 overexpression was unknown. Methods Immunohistochemical analyses of MAL2 and TPD52 expression were performed using tissue microarray sections including benign, borderline and malignant epithelial ovarian tumours. Inmmunohistochemical staining intensity and distribution was assessed both visually and digitally. Results MAL2 and TPD52 were significantly overexpressed in high-grade serous carcinomas compared with serous borderline tumours. MAL2 expression was highest in serous carcinomas relative to other histological subtypes, whereas TPD52 expression was highest in clear cell carcinomas. MAL2 expression was not related to patient survival, however high-level TPD52 staining was significantly associated with improved overall survival in patients with stage III serous ovarian carcinoma (log-rank test, p Conclusions MAL2 is frequently overexpressed in ovarian carcinoma, and TPD52 overexpression is a favourable independent prognostic marker of potential value in the management of ovarian carcinoma patients.

  7. Arterite de Takayasu diagnosticada durante o puerpério em mulher com doença hipertensiva gestacional: relato de caso = Takayasu Arteritis diagnosed during puerperium in a woman with pregnancy-induced hypertension: case report

    OpenAIRE

    Hentschke, Marta Ribeiro

    2014-01-01

    Objetivos: Descrever um caso de Arterite de Takayasu diagnosticada durante o puerpério precoce, demonstrando a importância da aferição adequada da pressão arterial para o diagnóstico da doença hipertensiva gestacional. Descrição do caso: Uma mulher de 40 anos, em sua quarta gestação, com idade gestacional de 36 semanas e três dias, foi hospitalizada por gestação de alto risco devido a hipertensão arterial sistêmica crônica. Durante a internação observou-se diferença nos níveis tensionais e...

  8. Trabalhador portuário: perfil de doenças ocupacionais diagnosticadas em serviço de saúde ocupacional Trabajador portuario: perfil de enfermedades ocupacionales diagnosticadas en un servicio de salud ocupacional Dock worker: profile of occupational diseases diagnosed in an occupational health service

    Directory of Open Access Journals (Sweden)

    Marlise Capa Verde de Almeida

    2012-01-01

    Full Text Available OBJETIVO: Identificar as doenças diagnosticadas em trabalhadores portuários avulsos, atendidos em um ambulatório de medicina do trabalho portuário. MÉTODOS: Estudo quantitativo descritivo com análise retrospectiva, que apresentou como fonte de dados as fichas de atendimento médico dos trabalhadores portuários avulsos entre 2000 e 2009. A coleta de dados desenvolveu-se mediante aplicação de um formulário predeterminado e procedeu-se à análise quantitativa descritiva em 953 fichas médicas dos trabalhadores. RESULTADOS: totalizou-se 953 fichas médicas (94,7%, das quais 90,47% pertenciam a trabalhadores do sexo masculino, 52% na faixa etária acima de 50 anos e 51,7% com mais de 19 anos de atuação. Identificaram-se 527 diagnósticos, sendo os principais relacionados ao trabalho: hipertensão (8,3%, lombalgia (6,2%, outras doenças pulmonares (1,7% e episódios depressivos (1,2%. CONCLUSÃO: constatou-se o acometimento do trabalhador por patologias ocupacionais de ordem mental, circulatória, respiratória e osteomuscular, evidenciando morbidades que o afetam e interferem em sua qualidade de vida e na produtividade das atividades laborais.OBJETIVO: Identificar las enfermedades diagnosticadas en trabajadores portuarios independientes, atendidos en un consultorio externo de medicina del trabajo portuario. MÉTODOS: Estudio cuantitativo descriptivo con análisis retrospectivo, que presentó como fuente de datos las fichas de atención médica de los trabajadores portuarios independientes entre 2000 y 2009. La recolección de los datos se desarrolló mediante la aplicación de un formulario estructurado y se procedió a realizar el análisis cuantitativo descritivo de 953 fichas médicas de los trabajadores. RESULTADOS: De un total de 953 fichas médicas (94,7%, el 90,47% pertenecían a trabajadores del sexo masculino, el 52% se encontraba en el grupo etáreo arriba de los 50 años y el 51,7% con más de 19 años de actuación. Se

  9. Performances of air source heat pump system for a kind of mal-defrost phenomenon appearing in moderate climate conditions

    International Nuclear Information System (INIS)

    Highlights: ► Mal-defrost performances of ASHP in moderate environment are investigated. ► The system COP decreases to 2.3 under environment temperature of 7.9 °C. ► The decrease of the ASHP heating capacity can get to 43.4%. ► The origins of this special mal-defrost phenomenon were discussed. ► Suggestions were proposed to modify the current defrosting control strategies. - Abstract: To quantify the performance drop of the air source heat pump (ASHP) system under a special kind of mal-defrost phenomenon appearing in moderate climate conditions, a field test was conducted for 8 days at the initial stage of a heating season in Beijing, China. The mal-defrost was found with the more than 60% frosted area of the outdoor heat exchanger after the system running 5 days. During this frosting period, the system COP was significantly degraded, only 2.3 under an environment temperature of 7.9 °C. Comparing the test data before and after frosting, it was found that the mal-defrost decreased the COP up to 40.4% and the heating capacity to 43.4%. Such low energy efficiency continued quite a long time until the defrost control was started up manually by the authors. After defrosting, the COP reclaimed to the normal level of 5.0. The origins of this special mal-defrost phenomenon were discussed. And some suggestions were proposed to modify the current defrosting control strategy, which were helpful to avoid the mal-defrost problem in the current ASHP system and therefore improve the system performances

  10. Pequeno mal epiléptico em crianças. Considerações sobre o efeito do tridione em 4 casos

    Directory of Open Access Journals (Sweden)

    Antonio B. Lefévre

    1949-03-01

    Full Text Available The author administered Tridione in four patients under five years of age with "petit mal" seizures. In all cases there was complete disappearance of the seizures eventhough small doses were used. In one case the EEG, taken after the Tridione treatment, did not show the previous "petit mal" pattern. In no case there were signs of intolerance. In conclusion the author thoroughly agree that Tridione is the drug of choice in "petit mal" seizures.

  11. DMPD: The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 17449723 The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling. Sh...Show The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling. PubmedID 17449723 Title The Troll in Toll: Mal...eedy FJ, O'Neill LA. J Leukoc Biol. 2007 Aug;82(2):196-203. Epub 2007 Apr 20. (.png) (.svg) (.html) (.csml)

  12. Relationship between diet and benign prostatic hyperplasia Relación entre la dieta y el desarrollo de Hiperplasia Prostática Benigna: ¿Qué nos dice la evidencia científica actual?

    Directory of Open Access Journals (Sweden)

    Jon Kepa Balparda Arias

    2010-02-01

    Full Text Available

    Benign prostatic hyperplasia is very common in the general population, both from the histological and the clinical points of view. The role of different factors in its development has been defined by means of epidemiological studies. One such factor is the composition of the diet, as the regular consumption of certain foods may either protect against benign prostatic hyperplasia or increase the risk of its development. Among foods which may play a protective role are lycopene, phytoestrogens and vegetables. On the other hand, the risk of developing the disease may be increased by a diet rich in fat and calories. In this article the main clinical trials concerning this relationship are reviewed, as a way of informing physicians on the dietetic patterns that may influence the frequency or the symptoms of this disease.

    La hiperplasia prostática benigna es muy común en la población general, tanto desde el punto de vista histológico como del clínico. El papel en ella de diversos factores se ha definido por medio de estudios epidemiológicos. Entre ellos está el consumo regular de algunos alimentos que podría actuar como un factor protector o de riesgo para el posterior desarrollo de la enfermedad. Entre los compuestos demostrados como benéficos para la salud prostática están los licopenos, los fitoestrógenos y las verduras. Por otro lado, entre los que podrían aumentar el riesgo de sufrir la hiperplasia prostática benigna se incluyen las dietas hipercal

  13. Tagosodes orizicolus: A new potential vector of Mal de Río Cuarto virus

    OpenAIRE

    2008-01-01

    Una enfermedad que afecta severamente el rendimiento del cultivo de maíz es conocida como mal de Río Cuarto. El vector más importante es Delphacodes kuscheli. Este trabajo tuvo como objetivo determinar la capacidad vectora de una nueva especie, Tagosodes orizicolus, en campo y bajo condiciones experimentales. Los ensayos de transmisión se realizaron con ambas especies simultáneamente. Para la adquisición, latencia e infección se utilizaron los tiempos considerados óptimos para D. kuscheli. La...

  14. El mal de ojo como enfermedad: elitelore y folklore en Iberoamérica

    Directory of Open Access Journals (Sweden)

    Idoyaga Molina, Anatilde

    2014-06-01

    Full Text Available The article claims that general theories about the evil eye lore have not considered its occurrences as an illness, the gazer´s and victim´s characterization in terms of ancient Western medicine, as well as the naturalization of moral contents. The authors sustain that the evil eye in Iberoamerica is a folk illness, whose etiological theories exceed the human domain, including animals as aggressors. The evil eye lore as an illness incorporates natural etiologies, and social theories linked to envy, anger, fondness and love. To overcome these supposed contradictions, the authors call the attention to consider the historical processes of construction of the evil eye lore, taking into account the process of filtering down from the elite and medical official knowledge to popular sectors, underlining the relevance of being aware of the evil eye was defined as a real disease, during the Middle and Modern Ages.Revisamos los marcos conceptuales del mal de ojo, destacando que tales teorías dejan de lado sus manifestaciones como enfermedad, la caracterización de los ojeadores y de las víctimas en términos de la antigua medicina científica. Los autores sostienen que el mal de ojo en Iberoamérica es el nombre de una enfermedad, cuyos contenidos y teorías etiológicas exceden el dominio humano, incluyendo ojeadores animales. Como enfermedad incorpora causas naturales, además de causas sociales ligadas con la envidia, los celos, el encono y el cariño. Para entender estas manifestaciones, aparentemente contradictorias, se llama la atención sobre la relevancia de considerar los procesos históricos de construcción de la creencia en el mal de ojo, la relación entre los saberes de elite y los procesos de popularización de esos saberes, subrayando la relevancia del reconocimiento del mal de ojo como enfermedad por la antigua medicina académica en tales procesos.

  15. Do mal ao banal: Uma interpretação do discurso social sobre a SIDA

    OpenAIRE

    Lopes, Maria de Fátima Triguinho

    2001-01-01

    Dissertação de mestrado em Psicopatologia e Psicologia Clínica Será que um mal passou a banal, foi a questão de partida para analisarmos diferentes perspectivas sociais sobre a SIDA, doença que coloca um amplo espectro de inquietações, mas com a qual convivemos já quase pacificamente. Esta dissertação procura encontrar nos discursos sociais sobre a doença, em particular nos discursos religioso, científico e psicológico, a evolução do pensamento social, bem como as invariantes que lhe sã...

  16. ACCUMULATION OF POLYHYDROXYALKANOIC ACIDS BY AZOTOBACTER CHROOCOCCUM MAL-201 FROM ORGANIC WASTE

    OpenAIRE

    Soma Pal Saha; A. Patra; P. B. Ghosh; A.K. Paul

    2013-01-01

    Azotobacter chroococcum MAL-201 (MTCC 3853), a free-living nitrogen-fixing bacterium accumulated intracellular poly(3-hydroxybutyric acid) [P(3HB)] accounting 69% of cell dry weight (CDW) when grown in nitrogrn-free Stockdale medium containing 2% (w/v) glucose. It also produced copolymer of poly(3-hydroxybutyrate co-3-hydroxyvalerate) [P(3HB-co-3HV)] using glucose as primary carbon source and valerate cas cosubstrate. To make the polymer production cost effective four types of waste material ...

  17. Effect of refrigerant mal-distribution in fin-and-tube evaporators on system performance

    DEFF Research Database (Denmark)

    Kærn, Martin Ryhl; Elmegaard, Brian; Larsen, Lars Finn Sloth

    2009-01-01

    Refrigerant mal-distribution in fin-and-tube evaporators for residential air-conditioning (RAC) is investigated numerically in this paper. A model of the system is developed in the object-oriented modeling language Modelica. Themodels of the compressor and expansion valve are static, whereas...... the condenser is a dynamic moving boundary model. The evaporator model is a dynamic distributed one-dimensional homogeneous equilibrium model, in order to capture the distribution phenomena. Fin-and-tube heat exchangers usually have a complex circuitry, however the evaporator will be simplified to be two...

  18. Malária cerebral e AIDS: relato de caso Cerebral malaria and AIDS: case report

    Directory of Open Access Journals (Sweden)

    S. L. Hinrichsen

    1996-06-01

    Full Text Available Embora não esteja definitivamente comprovada que a severidade da malária esteja associada com o vírus da imunodeficiência humana (HIV, sabe-se que a infecção pelo Plasmodium falciparum pode favorecer uma rápida evolução da infecção pelo HIV. Além disso a associação da malária com HIV/AIDS, do ponto de vista clínico, pode ser extremamente grave face a ocorrência de outros microorganismos e/ou neoplasias, o que piora a evolução e prognóstico dos pacientes. A concomitância do vírus HIV com o Plasmodium em zonas endêmicas de malária, é uma possibilidade que deve ser sempre pensada, visto que a sua transmissão está relacionada a fatores de risco ligados aos comportamentos das pessoas, que nem sempre são logo revelados e/ou identificados. Os autores descrevem um caso de malária cerebral por Plasmodium vivaxe Plasmodiumfalciparum em um paciente com AIDS. Descrevem sua evolução clínica e terapêutica.Although it has not been definitely proven that the severity of malaria is associated to human immunodeficiency virus (HIV we know that infection through Plasmodium falciparum can favor a rapid evolution of the HIV infection. Besides, association of malaria with HIV/AIDS from a clinical point of view can be clinically severe in the face of the occurrence of other microorganisms or neoplasias, which worsens the evolution and prognosis of the affected patients. The concurrence of HIV with Plasmodium in malaria endemic zones is a possibility which should always be taken into consideration, since transmission is related to risk factors caused by people's behavior which are not always promptly revealed and/or identified. The authors report one case of brain malaria infection by Plasmodium vivax and Plasmodium falciparum in a patient with AIDS. They describe the clinical evolution and therapy.

  19. Exposure to Glycolytic Carbon Sources Reveals a Novel Layer of Regulation for the MalT Regulon

    Directory of Open Access Journals (Sweden)

    Sylvia A. Reimann

    2011-01-01

    Full Text Available Bacteria adapt to changing environments by means of tightly coordinated regulatory circuits. The use of synthetic lethality, a genetic phenomenon in which the combination of two nonlethal mutations causes cell death, facilitates identification and study of such circuitry. In this study, we show that the E. coli ompR malTcon double mutant exhibits a synthetic lethal phenotype that is environmentally conditional. MalTcon, the constitutively active form of the maltose system regulator MalT, causes elevated expression of the outer membrane porin LamB, which leads to death in the absence of the osmoregulator OmpR. However, the presence and metabolism of glycolytic carbon sources, such as sorbitol, promotes viability and unveils a novel layer of regulation within the complex circuitry that controls maltose transport and metabolism.

  20. Distinct mechanism of activation of two transcription factors, AmyR and MalR, involved in amylolytic enzyme production in Aspergillus oryzae.

    Science.gov (United States)

    Suzuki, Kuta; Tanaka, Mizuki; Konno, Yui; Ichikawa, Takanori; Ichinose, Sakurako; Hasegawa-Shiro, Sachiko; Shintani, Takahiro; Gomi, Katsuya

    2015-02-01

    The production of amylolytic enzymes in Aspergillus oryzae is induced in the presence of starch or maltose, and two Zn2Cys6-type transcription factors, AmyR and MalR, are involved in this regulation. AmyR directly regulates the expression of amylase genes, and MalR controls the expression of maltose-utilizing (MAL) cluster genes. Deletion of malR gene resulted in poor growth on starch medium and reduction in α-amylase production level. To elucidate the activation mechanisms of these two transcription factors in amylase production, the expression profiles of amylases and MAL cluster genes under carbon catabolite derepression condition and subcellular localization of these transcription factors fused with a green fluorescent protein (GFP) were examined. Glucose, maltose, and isomaltose induced the expression of amylase genes, and GFP-AmyR was translocated from the cytoplasm to nucleus after the addition of these sugars. Rapid induction of amylase gene expression and nuclear localization of GFP-AmyR by isomaltose suggested that this sugar was the strongest inducer for AmyR activation. In contrast, GFP-MalR was constitutively localized in the nucleus and the expression of MAL cluster genes was induced by maltose, but not by glucose or isomaltose. In the presence of maltose, the expression of amylase genes was preceded by MAL cluster gene expression. Furthermore, deletion of the malR gene resulted in a significant decrease in the α-amylase activity induced by maltose, but had apparently no effect on the expression of α-amylase genes in the presence of isomaltose. These results suggested that activation of AmyR and MalR is regulated in a different manner, and the preceding activation of MalR is essential for the utilization of maltose as an inducer for AmyR activation.

  1. Establishment of the MAL-ED birth cohort study site in Vellore, Southern India.

    Science.gov (United States)

    John, Sushil M; Thomas, Rahul J; Kaki, Shiny; Sharma, Srujan L; Ramanujam, Karthikeyan; Raghava, Mohan V; Koshy, Beena; Bose, Anuradha; Rose, Anuradha; Rose, Winsley; Ramachandran, Anup; Joseph, A J; Babji, Sudhir; Kang, Gagandeep

    2014-11-01

    The Indian Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) site is in Vellore, Tamil Nadu, in south India and is coordinated by the Christian Medical College, Vellore, which has many years of experience in establishing and following cohorts. India is a diverse country, and no single area can be representative with regard to many health and socioeconomic indicators. The site in Vellore is an urban semiorganized settlement or slum. In the study site, the average family size is 5.7, adults who are gainfully employed are mostly unskilled laborers, and 51% of the population uses the field as their toilet facility. Previous studies from Vellore slums have reported stunting in well over a third of children, comparable to national estimates. The infant mortality rate is 38 per 1000 live births, with deaths due mainly to perinatal and infectious causes. Rigorous staff training, monitoring, supervision and refinement of tools have been essential to maintaining the quality of the significantly large quantity of data collected. Establishing a field clinic within the site has minimized inconvenience to participants and researchers and enabled better rapport with the community and better follow-up. These factors contribute to the wealth of information that will be generated from the MAL-ED multisite cohort, which will improve our understanding of enteric infections and its interactions with malnutrition and development of young children.

  2. Olhar de dirigentes sindicais sobre qualidade de vida no trabalho e mal-estar no trabalho

    Directory of Open Access Journals (Sweden)

    Remigio Todeschini

    2013-06-01

    Full Text Available O objeto do artigo consistiu em conhecer as percepções de dirigentes sindicais metalúrgicos e químicos sobre o tema Qualidade de Vida no Trabalho (QVT e as fontes de mal-estar no trabalho nessas categorias profissionais. A natureza metodológica aplicada foi quantitativa e qualitativa com utilização do software Alceste. Participaram da pesquisa 81 dirigentes sindicais brasileiros (56 dirigentes químicos e 25 metalúrgicos, 85% do gênero masculino e 15% do gênero feminino oriundos das regiões sudeste, sul e nordeste do país, com aplicação do questionário via e-mail. Os resultados encontrados forneceram bases empíricas para a formulação de recomendações em Ergonomia da Atividade visando prevenir as fontes de mal-estar no trabalho. Foram reforçadas as bases teóricas da Abordagem de Ergonomia da Atividade Aplicada à Qualidade de Vida no Trabalho (EAA_QVT e o desenho de subsídios para a formulação de políticas públicas neste campo.

  3. Návrh malé vodní nádrže

    OpenAIRE

    Galuška, Martin

    2013-01-01

    Práce se zabývá posouzením možnosti návrhu malé vodní nádrže na vytipovaném území obce Bezměrov. Součástí práce je pojednání o typech a funkcích malých vodních nádrží a jejich vodohospodářském řešení. Je vyhodnocen geologický průzkum lokality, který mapuje skladbu vrstev zeminy a dostupných materiálů pro výstavbu hráze. Pro konkrétní uvažované profily hráze je vypracována vodní bilance, která hodnotí specifický odtok z povodí, výpar a průsak vody tělesem zjednodušeně navržené hráze. Vzniká ta...

  4. A review of the prevalence and factors responsible for mal-nutrition in Pakistan

    Directory of Open Access Journals (Sweden)

    Hafsa Hina

    2015-01-01

    Full Text Available Problems occupying special attention identified by the World Health Organization also include Childhood malnutrition (Beagle hole et al., 1993. Development goals are also program by the United Nations to halve the problem of under nutrition (Alderman et al., 2005. Despite of the involvement of international organizations still under nutrition has a main contribution to the high mortality rate of the children in the most part of the world (Caulfield et al., 2004. Poverty plays a main part in the high prevalence of childhood under nutrition. The child is said to be under-weight when its weight is lower than the weight of the reference rage for that age. The weight for height deficiency is known as wasting, while height for age deficiency as stunting. Wasting may be due to acute food shortage while prolonged food deprivation can cause stunting (Cosminsky et al., 1993; de Onis et al., 2000; Fernandez et al., 2002; and Zere & McIntyre, 2003. The factors responsible for the predisposition of children to mal nutrition vary and ranges from political instability to the economical status of the area (de Onis et al., 2000. Therefore protocols developed for the preventive measures of mal-nutrition should be multifaceted. 

  5. Aberrant methylation of LINE-1, SLIT2, MAL and IGFBP7 in non-small cell lung cancer.

    Science.gov (United States)

    Suzuki, Makoto; Shiraishi, Kenji; Eguchi, Ayami; Ikeda, Koei; Mori, Takeshi; Yoshimoto, Kentaro; Ohba, Yasuomi; Yamada, Tatsuya; Ito, Takaaki; Baba, Yoshifumi; Baba, Hideo

    2013-04-01

    Genome-wide DNA hypomethylation and gene hypermethylation play important roles in instability and carcino-genesis. Methylation in long interspersed nucleotide element 1 (LINE-1) is a good indicator of the global DNA methylation level within a cell. Slit homolog 2 (SLIT2), myelin and lymphocyte protein gene (MAL) and insulin-like growth factor binding protein 7 (IGFBP7) are known to be hypermethylated in various malignancies. The aim of the present study was to assess the precise methylation levels of LINE-1, SLIT2, MAL and IGFBP7 in non-small cell lung cancer (NSCLC) using a pyrosequencing assay. Methylation of all regions was examined in 56 primary NSCLCs using a pyrosequencing assay. Changes in mRNA expression levels of SLIT2, MAL and IGFBP7 were measured before and after treatment with a demethylating agent. Methylation of these genes was also examined in 9 lung cancer cell lines using RT-PCR and a pyrosequencing assay. Frequencies of hypomethylation of LINE-1 and hypermethylation of SLIT2, MAL and IGFBP7, defined by predetermined cut off values, were 55, 64, 46 and 54% in NSCLCs, respectively and exhibited tumor-specific features. The hypermethylation of all genes was well correlated with changes in expression. The methylation level and frequency of MAL were significantly higher in smokers and in patients without EGFR mutations. Through accurate measurement of methylation levels using pyrosequencing, hypomethylation of LINE-1 and hypermethylation of SLIT2, MAL and IGFBP7 were frequently detected in NSCLCs and associated with various clinical features. Analysis of the methylation profiles of these genes may, therefore, provide novel opportunities for the therapy of NSCLCs.

  6. MalT, the regulatory protein of the Escherichia coli maltose system, is an ATP-dependent transcriptional activator.

    OpenAIRE

    Richet, E; Raibaud, O

    1989-01-01

    We show that MalT, the transcriptional activator of the Escherichia coli maltose regulon, specifically binds ATP and dATP with a high affinity (Kd = 0.4 microM) and exhibits a weak ATPase activity. Using an abortive initiation assay, we further show that activation of open complex formation by MalT depends on the presence of ATP in addition to that of maltotriose, the inducer of the maltose system. Similar experiments in which ATP was replaced by ADP or AMP-PNP, a non-hydrolysable analogue of...

  7. MAL2 and tumor protein D52 (TPD52) are frequently overexpressed in ovarian carcinoma, but differentially associated with histological subtype and patient outcome

    International Nuclear Information System (INIS)

    The four-transmembrane MAL2 protein is frequently overexpressed in breast carcinoma, and MAL2 overexpression is associated with gain of the corresponding locus at chromosome 8q24.12. Independent expression microarray studies predict MAL2 overexpression in ovarian carcinoma, but these had remained unconfirmed. MAL2 binds tumor protein D52 (TPD52), which is frequently overexpressed in ovarian carcinoma, but the clinical significance of MAL2 and TPD52 overexpression was unknown. Immunohistochemical analyses of MAL2 and TPD52 expression were performed using tissue microarray sections including benign, borderline and malignant epithelial ovarian tumours. Inmmunohistochemical staining intensity and distribution was assessed both visually and digitally. MAL2 and TPD52 were significantly overexpressed in high-grade serous carcinomas compared with serous borderline tumours. MAL2 expression was highest in serous carcinomas relative to other histological subtypes, whereas TPD52 expression was highest in clear cell carcinomas. MAL2 expression was not related to patient survival, however high-level TPD52 staining was significantly associated with improved overall survival in patients with stage III serous ovarian carcinoma (log-rank test, p < 0.001; n = 124) and was an independent predictor of survival in the overall carcinoma cohort (hazard ratio (HR), 0.498; 95% confidence interval (CI), 0.34-0.728; p < 0.001; n = 221), and in serous carcinomas (HR, 0.440; 95% CI, 0.294-0.658; p < 0.001; n = 182). MAL2 is frequently overexpressed in ovarian carcinoma, and TPD52 overexpression is a favourable independent prognostic marker of potential value in the management of ovarian carcinoma patients

  8. Comparative in vivo study of precursors of PpIX (ALA and MAL) used topically in photodynamic therapy

    Science.gov (United States)

    Rego, Raquel F.; Inada, Natalia M.; Ferreira, Juliana; Araújo-Moreira, Fernando M.; Bagnato, Vanderlei S.

    2009-06-01

    The efficacy of Photodynamic Therapy (PDT) combined with aminolevulinic acid (ALA) or methyl aminolevulinate (MAL) in treatment of cancer has been studied for over ten years. However, there is no established dose for the topical use of these drugs in PDT. The purpose of this study was the comparison of induced PDT response of ALAsense (5-aminolevulinic acid - ALA) and Metvix (methyl aminolevulinate - MAL). Depth of necrosis induced by PDT was analyzed in normal liver of male Wistar rats, using different light doses and topical application of both PpIX precursors - ALA and MAL. PDT was performed with a diode laser at 630 nm with different doses of light (20, 50, 100 and 200 J/cm2), and intensity of 250 mW/cm2. Depth of necrosis analysis was used to calculate the threshold dose for each drug. The results showed that MAL-PDT presented a better response than ALA-PDT, mainly due to formulation differences. Moreover, the ability of the ALA PpIX production was more efficient.

  9. Role of Helicobacter pylori in stomach cancer after partial gastrectomy for benign ulcer disease Papel del Helicobacter pylori en el cáncer gástrico tras gastrectomía parcial por úlcera benigna

    Directory of Open Access Journals (Sweden)

    A. Seoane

    2005-11-01

    Full Text Available Objective: to determine the prevalence of Helicobacter pylori infection in patients having undergone gastrectomy for non-neoplastic disease who later developed gastric stump cancer. Material and methods: retrospective study of all patients with partial gastrectomy for non-malignant peptic disease who were submitted to an endoscopic exploration between 1995 and 2001. A comparison was made of major clinical and histological characteristics, and the presence of Helicobacter pylori among patients with and without gastric cancer in the stomach remnant. Results: a total of 73 patients were studied in this period. Fifteen patients (20.5% had remnant-stump gastric cancer. All but one were adenocarcinomas (71% intestinal and 29% diffuse, respectively. The average time between diagnosis of gastric cancer and previous gastrectomy was 32 (14-48 years. There was a higher detection rate of Helicobacter pylori in patients with cancer in the gastric remnant (100 vs. 81.5%, respectively, p Objetivo: determinar la prevalencia de la infección por Helicobacter pylori en pacientes gastrectomizados por enfermedad no neoplásica, y que han desarrollado posteriormente cáncer gástrico. Material y métodos: estudio retrospectivo con reclutamiento de todos los pacientes con gastrectomía parcial por enfermedad péptica benigna que han sido sometidos a una exploración endoscópica entre 1995-2001. Se ha realizado una comparación de las principales características clínicas e histológicas y de la presencia de Helicobacter pylori en los pacientes con y sin cáncer del remanente gástrico. Resultados: se han estudiado un total de 73 pacientes en este periodo. Se han encontrado 15 pacientes (20,5% con cáncer en el remanente gástrico, 14 adenocarcinomas (71% tipo intestinal y 29% tipo difuso y un linfoma. El tiempo transcurrido entre el diagnóstico de cáncer gástrico y la gastrectomía previa ha sido de 32 (14-48 años. Se ha detectado un alto porcentaje de infecci

  10. La burocracia como vocación. El mal natural en Sempere y Guarinos

    Directory of Open Access Journals (Sweden)

    Rafael HERRERA GUILLÉN

    2009-11-01

    Full Text Available RESUMEN: La obra de Sempere y Guarinos abarca gran cantidad de temas, pero todos ellos tienen el denominador común de contribuir a modernizar y mejorar la sociedad y la política españolas. En la cuestión de los terremotos se barajaba la comprensión del mal natural y la necesidad de darle una respuesta racional y no religiosa.ABSTRACT: The work of Sempere y Guarinos includes a lot of subjets, but the main purpose of his works is the modernization of spanish politics and society. About earthquakes, Sempere worked in order to clarify the question about natural catastrophes and the need for give a rational, not religious, answer to that question.

  11. Mal de Debarquement Syndrome: A Rare Entity—A Case Report and Review of the Literature

    Directory of Open Access Journals (Sweden)

    Veronica Nwagwu

    2015-01-01

    Full Text Available Mal de Debarquement Syndrome (MDS is a rare, understudied, underdiagnosed, and self-limiting condition. Etiology and incidence are unknown. It is characterized by abnormal sensation of motion/balance reported after travel by air, land, and sea; being reexposed to motion/activity relieves it. Symptoms may last from minutes to years. Workup though required reveals no findings; it is a diagnosis of exclusion. While no efficacious treatment exists, amitriptyline and benzodiazepines as well as supportive therapy have proved to be useful. We have described a 40-year-old Caucasian female who presented for the evaluation of persistent rocking and swaying sensation after a ship cruise which lasted for one week. Patient was treated with benzodiazepines after extensive workup and is now stable. A high index of suspicion is required to make a diagnosis.

  12. SmartMal: A Service-Oriented Behavioral Malware Detection Framework for Mobile Devices

    Science.gov (United States)

    Wu, Zhizhong; Li, Xi; Zhou, Xuehai; Wang, Aili; Hung, Patrick C. K.

    2014-01-01

    This paper presents SmartMal—a novel service-oriented behavioral malware detection framework for vehicular and mobile devices. The highlight of SmartMal is to introduce service-oriented architecture (SOA) concepts and behavior analysis into the malware detection paradigms. The proposed framework relies on client-server architecture, the client continuously extracts various features and transfers them to the server, and the server's main task is to detect anomalies using state-of-art detection algorithms. Multiple distributed servers simultaneously analyze the feature vector using various detectors and information fusion is used to concatenate the results of detectors. We also propose a cycle-based statistical approach for mobile device anomaly detection. We accomplish this by analyzing the users' regular usage patterns. Empirical results suggest that the proposed framework and novel anomaly detection algorithm are highly effective in detecting malware on Android devices. PMID:25165729

  13. SmartMal: A Service-Oriented Behavioral Malware Detection Framework for Mobile Devices

    Directory of Open Access Journals (Sweden)

    Chao Wang

    2014-01-01

    Full Text Available This paper presents SmartMal—a novel service-oriented behavioral malware detection framework for vehicular and mobile devices. The highlight of SmartMal is to introduce service-oriented architecture (SOA concepts and behavior analysis into the malware detection paradigms. The proposed framework relies on client-server architecture, the client continuously extracts various features and transfers them to the server, and the server’s main task is to detect anomalies using state-of-art detection algorithms. Multiple distributed servers simultaneously analyze the feature vector using various detectors and information fusion is used to concatenate the results of detectors. We also propose a cycle-based statistical approach for mobile device anomaly detection. We accomplish this by analyzing the users’ regular usage patterns. Empirical results suggest that the proposed framework and novel anomaly detection algorithm are highly effective in detecting malware on Android devices.

  14. Musique du mal, musique du bien dans le théâtre baroque

    OpenAIRE

    Wolf, Robert Erich

    2012-01-01

    Si on cherche le fondement moral commun à la plupart des pièces de théâtre baroques, on le trouvera, il me semble, dans le conflit entre le Bien et le Mal. À l’époque baroque ce conflit prend la forme du débat, du dialogue, de la dialectique ; et, comme il arrive souvent dans l’art, l’opposition entre valeurs morales - ou psychologiques, ce qui au théâtre est équivalent - détermine en grande partie la forme de la pièce : on peut dire même qu’elle forme la pièce. Ce qui distingue l’art théâtra...

  15. Malé jednoválcové spalovací motory

    OpenAIRE

    Smolka, Josef

    2015-01-01

    Obsahem této práce je seznámit čtenáře s použitými technickými řešeními v oblasti malých jednoválcových motorů a stručný přehled alternativních paliv pro zážehové motory. Hlavním cílem je nabídnout ucelený přehled dostupných motorů a jejich parametrů. The content of this thesis is getting to know the reader with the technical solutions in the field of small single cylinder engines and a brief overview of alternative fuels for petrol engines. The main objective is to offer a comprehensive o...

  16. Desempenho escolar em crianças com epilepsia benigna da infância com pontas centrotemporais School performance in children with benign childhood epilepsy with centrotemporal spikes

    Directory of Open Access Journals (Sweden)

    Lineu Corrêa Fonseca

    2004-06-01

    Full Text Available Aspectos psicossociais em crianças com epilepsia benigna da infância com pontas centrotemporais (EBICT são objeto de controvérsias. O objetivo desta pesquisa foi estudar o desempenho escolar em crianças com EBICT. Vinte crianças foram submetidas ao Teste de Desempenho Escolar (TDE e comparadas a crianças sadias pareadas por idade e escolaridade. Foram estudadas as relações entre o TDE e a lateralidade do foco e o número de descargas ao eletrencefalograma. As crianças com EBICT tiveram, de modo significativo, mais freqüentemente do que as sadias, desempenho inferior no subteste de leitura e no escore total. As crianças com desempenho inferior em leitura apresentaram maior número de descargas do que aquelas com desempenho médio e superior. Não houve diferenças no TDE segundo a lateralidade do foco. O número de descargas, ao interferir com a função cerebral, pode ser um fator a explicar o desempenho mais baixo na leitura.Neuropsychological implications of benign childhood epilepsy with centrotemporal spikes-rolandic spikes (BECTS have not been adequately investigated. The aim of this study was to compare the results in a school performance test of patients with BECTS and normal age-matched controls. A total of 20 children with BECTS and 20 normal controls were submitted to anamnesis, clinical evaluation, Raven test, school performance test (SPT, digital electroencephalogram and quantitative electroencephalogram analysis. Comparing with normal controls, children with BECTS showed significantly lower SPT results, especially in reading test. There was an association between the higher number of rolandic spikes and inferior performance in SPT reading test. These findings suggest that discharges may be a factor in the genesis of lower performance in reading test in children with BECTS.

  17. Bhaktapur, Nepal: the MAL-ED birth cohort study in Nepal.

    Science.gov (United States)

    Shrestha, Prakash Sunder; Shrestha, Sanjaya Kumar; Bodhidatta, Ladaporn; Strand, Tor; Shrestha, Binob; Shrestha, Rita; Chandyo, Ram Krishna; Ulak, Manjeswori; Mason, Carl J

    2014-11-01

    The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) cohort study site in Nepal is located in the Bhaktapur municipality, 15 km east of Kathmandu, the capital city of Nepal. Bhaktapur, an ancient city famous for its traditional temples and buildings, is included on UNESCO's World Heritage List and is a major tourist attraction in Nepal. Nepal is a land-locked country located in South Asia between China and India with an area of 147 181 km(2), ranging from sea-level plains to Mount Everest, the world's highest peak. The total population as of the 2011 census was 26.6 million, with an average annual population growth rate of 1.4. Nepal is one of the world's least developed countries and is ranked 157 of 186 in the 2013 Human Development Report; one-third of the Nepali population lives below the poverty line. The current under-5 mortality rate is 54 per 1000 live births, the infant mortality rate is 46 per 1000 live births, and the neonatal mortality rate is 33 per 1000 live births. Vaccine coverage for all Expanded Program on Immunization vaccines is >80%. Among children, the most common diseases contributing to significant morbidity and mortality are acute respiratory infection and dehydration from severe diarrhea. In this article, we report on the geographic, demographic, and socioeconomic features of the Bhaktapur MAL-ED site and describe the data that informed our cohort recruitment strategy. PMID:25305301

  18. ACCUMULATION OF POLYHYDROXYALKANOIC ACIDS BY AZOTOBACTER CHROOCOCCUM MAL-201 FROM ORGANIC WASTE

    Directory of Open Access Journals (Sweden)

    Soma Pal Saha

    2013-08-01

    Full Text Available Azotobacter chroococcum MAL-201 (MTCC 3853, a free-living nitrogen-fixing bacterium accumulated intracellular poly(3-hydroxybutyric acid [P(3HB] accounting 69% of cell dry weight (CDW when grown in nitrogrn-free Stockdale medium containing 2% (w/v glucose. It also produced copolymer of poly(3-hydroxybutyrate co-3-hydroxyvalerate [P(3HB-co-3HV] using glucose as primary carbon source and valerate cas cosubstrate. To make the polymer production cost effective four types of waste material of different origin were tested for growth and polymer production. Stockdale medium supplemented with 1% (w/v waste materials failed to yield good growth and polymer accumulation. Two–step cultivation was adopted for better growth and enhanced polymer accumulation. The candy factory waste was most suitable for synthesis of P(3HB accounting 17.8 and 40.58% using single and two-step cultivation conditions respectively. Wastes of domestic and poultry origin produced P(3HB-co-3HV with 3HV content 28.8 and 21.5 mol% respectively in two-step cultivation. Increase concentration of these wastes resulted in further upliftment of 3HV content of polymer with reduced growth and polymer accumulation. However, at optimum incubation the strain MAL-201 cells accumulated P(3HB 48.5% of CDW (at 40h from candy factory waste and P(3HB-co-3HV 24.75 % of CDW with 3HV 34.65 mol % from domestic waste. Intrinsic viscosity, molecular weight and thermal degradation of the polymers accumulated in the cells grown in glucose, glucose with valerate and glucose with waste were compared.

  19. MAL Overexpression Leads to Disturbed Expression of Genes That Influence Cytoskeletal Organization and Differentiation of Schwann Cells

    Directory of Open Access Journals (Sweden)

    Daniela Schmid

    2014-09-01

    Full Text Available In the developing peripheral nervous system, a coordinated reciprocal signaling between Schwann cells and axons is crucial for accurate myelination. The myelin and lymphocyte protein MAL is a component of lipid rafts that is important for targeting proteins and lipids to distinct domains. MAL overexpression impedes peripheral myelinogenesis, which is evident by a delayed onset of myelination and reduced expression of the myelin protein zero (Mpz/P0 and the low-affinity neurotrophin receptor p75NTR . This study shows that MAL overexpression leads to a significant reduction of Mpz and p75NTR expression in primary mouse Schwann cell cultures, which was already evident before differentiation, implicating an effect of MAL in early Schwann cell development. Their transcription was robustly reduced, despite normal expression of essential transcription factors and receptors. Further, the cAMP response element-binding protein (CREB and phosphoinositide 3-kinase signaling pathways important for Schwann cell differentiation were correctly induced, highlighting that other so far unknown rate limiting factors do exist. We identified novel genes expressed by Schwann cells in a MAL-dependent manner in vivo and in vitro. A number of those, including S100a4, RhoU and Krt23, are implicated in cytoskeletal organization and plasma membrane dynamics. We showed that S100a4 is predominantly expressed by nonmyelinating Schwann cells, whereas RhoU was localized within myelin membranes, and Krt23 was detected in nonmyelinating as well as in myelinating Schwann cells. Their differential expression during early peripheral nerve development further underlines their possible role in influencing Schwann cell differentiation and myelination.

  20. AVALIAÇÃO DO NÍVEL SÉRICO DE ANTÍGENO PROSTÁTICO ESPECÍFICO (PSA) E RELAÇÃO COM HIPERPLASIA BENIGNA PROSTÁTICA E CÂNCER DE PRÓSTATA EM PACIENTES ATENDIDOS EM UM LABORATÓRIO DE ANÁLISES CLÍNICAS

    OpenAIRE

    Jaqueline HECK; Letícia Fernanda GIOMBELLI; Jean COLACITE; Cibeli Lunardeli de OLIVEIRA

    2015-01-01

    A próstata é a glândula do sistema reprodutor masculino, responsável por produzir o liquido seminal, podendo ser acometida pela hiperplasia prostática benigna, câncer e prostatite, sendo diagnosticados pelo toque retal, associado com os níveis elevados do Antígeno Prostático Especifico (PSA). A hiperplasia tem como sintomas o prostatismo, que provoca obstrução e sintomas irritativos. Já o câncer apresenta a ausência de sintomas na fase inicial da doença, apenas com sintomas semelhantes à hipe...

  1. Development of hypo-allergenic apples: silencing of the major allergen Mal d 1 gene in "Elstar" apple and the effect of grafting

    DEFF Research Database (Denmark)

    Krath, Britta; Eriksen, Folmer Damsted; Pedersen, Bjarne H.;

    2009-01-01

    of Mal d 1 mRNA were produced by RNA interference (RNAi) technology. Ten genetically modified (GM) apple lines were selected. In vitro plantlets were first transferred to a greenhouse, then grafted onto wild-type M.9 rootstock to promote the development of fruit-producing trees. Levels of Mal d 7 gene......Many people who are allergic to birch pollen are also allergic to apple fruit, due to cross-allergenicity. Since apples are the most extensively consumed fruit in Europe, it is highly relevant to develop a hypo-allergenic apple. Apples with significantly reduced levels of the allergen, Mal d 1, may...

  2. Epitope grafting, re-creating a conformational Bet v 1 antibody epitope on the surface of the homologous apple allergen Mal d 1

    DEFF Research Database (Denmark)

    Holm, Jens; Ferreras, Mercedes; Ipsen, Henrik;

    2011-01-01

    allergen Malus domestica group 1 (Mal d 1). Engineering of the epitope was accomplished by genetic engineering substituting amino acid residues in Mal d 1 differing between Bet v 1 and Mal d 1 within the epitope defined by the mAb BV16. The kinetic parameters characterizing the antibody binding interaction......Birch-allergic patients often experience oral allergy syndrome upon ingestion of vegetables and fruits, most prominently apple, that is caused by antibody cross-reactivity of the IgE antibodies in patients to proteins sharing molecular surface structures with the major birch pollen group 1 allergen...

  3. Le problème du mal dans le Guide des Perplexes et son arrière-plan talmudique

    Directory of Open Access Journals (Sweden)

    Costa, José

    2010-12-01

    Full Text Available At first sight, the question of evil is regarded in the Guide for the Perplexed in a paradoxical manner. Thus, in Guide I, 2, Maimonides examines the notions of good and evil as subjective evaluations possessing neither the rigour not the exactness of the notions of true and false. However, the question of evil occupies an essential place in the Guide, as various modern authors have shown. This question is important to Maimonides because he is, in this respect, the heir of the rabbinic tradition and his conception of evil is largely based on an interaction with the Talmudic and Midrašic texts. Therefore, we would like to review thirty-nine rabbinic ‘quotes’ which appear in chapters 8 to 24 in the third part of the Guide and deal with the origin of evil, the meaning of suffering and the evil inclination. Maimonides reappropriates the midrašim that are susceptible of being in agreement with his rationalist positions and also quotes some rabbinic traditions that are too close to mu ͑tazilism, undoubtedly aware of the more profound resemblance that exists between the rabbinic and mu ͑tazilite doctrines of evil and retribution.A primera vista, el problema del mal es abordado en la Guía de Perplejos de manera paradójica. Para Maimónides, las nociones de bien y mal son subjetivas y no resultan ni rigorosas ni exactas, a la inversa de las nociones de verdad y falsedad (Guía I, 2. Sin embargo, el problema del mal es muy importante en la Guía, como lo demostraran varios autores. Maimónides es el heredero de la tradición rabínica y existe en la Guía una interacción entre la filosofia de Maimónides y los textos talmúdicos y midrásicos. Es particularmente el caso de las treinta y nueve citas rabínicas de la Guía II, 8-24, que tratan del origen del mal, del significado del sufrimiento y de la inclinación al mal. Maimónides cita los midrašim que concuerdan con sus posiciones racionalistas y evoca también algunas tradiciones rab

  4. Epilepsia"Petit Mal" aspectos clínicos, eletrencefalográficos e evolutivos

    Directory of Open Access Journals (Sweden)

    Paulo Pinto Pupo

    1961-01-01

    Full Text Available In the past few years somewhat new yet often differing points of view have been affirmed refering to Petit Mal epilepsy, with regard to its clinical, eletrencephalographic and evolutive aspects. The classical concept of PM epilepsy as established by Lennox and Gibbs, with its well defined clinical and EEGraphic characteristics is continually being modified with new research work on clinical and EEGraphic aspects. Numerous clinical cases have been published whose evolution clashes with that classically described and likewise numerous are those cases where the EEG shows signs of focal electric activity besides spike and wave dis-rythmia. Cases have been known where surgical exerese on the focus causes temporary desappearance of the spike and wave disrythmia. The present concept now holding sway is that PM epilepsy is a kind of reaction of infantile encephalon to diverse harmful causes. From this it will be seen we are very far from the concept that PM epilepsy is a pure form of idiopathic epilepsy. For these reasons we decided to re-examine those cases observed between 1950 and 1960. With this in mind we chose 141 PM epilepsy cases, from among over 23000 epileptics, all examined under a standard criterion by a small group of senior assistants. All cases suspected of Psm epilepsy were excluded. The analysis of this group of patients was compared to that of another group with GM as well as PM seizures (104 patients; in 52 of these cases, studies were made concerning the evolutive, clinical and EEGra-phic aspects. METHOD: Clinical criterion was used for selection of the cases. The results of the analysis from the clinical and EEGraphic point of view were exhibited in demonstrative graphs. From the clinical point of view we strove to find out positive hereditary elements, organic cerebral injury factor (intellectual deficit, mood and behaviour disturbances, neurologic or somatic signs, as well as other development anomalies, the presence of febrile

  5. Aspectos clínicos e funcionais do equilíbrio corporal em idosos com vertigem posicional paroxística benigna Clinical and functional aspects of body balance in elderly subjects with benign paroxysmal positional vertigo

    Directory of Open Access Journals (Sweden)

    Daniela Patricia Vaz

    2013-04-01

    Full Text Available Vertigem Posicional Paroxística Benigna (VPPB pode alterar o equilíbrio corporal em pacientes idosos. OBJETIVO: Observar os efeitos da manobra de Epley em idosos com VPPB, avaliando os aspectos clínicos e funcionais do equilíbrio corporal. Forma de estudo: clínico e prospectivo. MÉTODO: Após o diagnóstico da doença (teste de DixHallpike, os testes Time Up and Go (TUGT, Clinical test of Sensory Interaction and Balance (CTSIB e o teste de membros inferiores (MMI foram realizados antes e após a manobra de reposicionamento de Epley modificada. RESULTADOS: O gênero feminino foi o mais prevalente e a média etária foi de 70,10 anos (DP = 7,00. Todos os pacientes apresentaram ductolitíase de canal posterior. Os seguintes sintomas melhoraram após a manobra: a instabilidade postural (p = 0,006, náusea e vômito (p = 0,021 e zumbido (p = 0,003. Em relação ao TUGT e o escore do teste de MMII, observou-se diminuição significante do tempo pós-manobra de Epley (p Benign paroxysmal positional vertigo (BPPV may compromise the balance of elderly subjects. OBJECTIVE: To observe the effects of the Epley maneuver in elderly subjects with BPPV and assess clinical and functional aspects of body balance. METHOD: This is a prospective clinical study. Patients diagnosed with BPPV (Dix-Hallpike test were submitted to the Timed Up & Go (TUG test, the Clinical Test of Sensory Interaction and Balance (CTSIB, and lower limb testing before and after they were repositioned using the modified Epley maneuver. RESULTS: Most subjects were females, and the group's mean age was 70.10 years (SD = 7.00. All patients had canalithiasis of the posterior canal. The following symptoms improved after the maneuver: postural instability (p = 0.006, nausea and vomiting (p = 0.021, and tinnitus (p = 0.003. Subjects improved their times significantly in the TUG and lower limb tests after the Epley maneuver (p < 0.001. Patients performed better on the CTSIB after the Epley

  6. A intervenção fonoaudiológica no pós-operatório da hipertrofia benigna do músculo masseter The miofunctional oral intervention in the surgery treatment for the masseter muscle hipertrophy

    Directory of Open Access Journals (Sweden)

    Laura Davison Mangilli

    2006-04-01

    Full Text Available OBJETIVO: descrever a abordagem fonoaudiológica no pós-operatório de pacientes que realizaram correção cirúrgica da hipertrofia do músculo masseter. METODOLOGIA: foram coletados dados referentes à avaliação e ao tratamento fonoaudiológico de 4 prontuários de sujeitos de ambos os gêneros, com faixa etária entre 16 e 24 anos, com hipertrofia benigna do músculo masseter, tratados cirurgicamente. RESULTADOS: as principais queixas pós-cirúrgicas estiveram relacionadas à limitação da abertura da boca, à dor na região da cirurgia, à rigidez muscular e a estalo em região da ATM. A terapia fonoaudiológica baseou-se em orientação quanto à retirada de hábitos deletérios; termoterapia na região do músculo masseter; manipulação da musculatura envolvida extra e intrabucais; alongamento da musculatura facial e cervical; alavanca de abertura forçada de boca e exercícios de órgãos fonoarticulatórios. CONCLUSÕES: a terapia fonoaudiológica apresenta-se como uma possibilidade de complementação ao tratamento cirúrgico, na adequação da amplitude dos movimentos mandibulares, assim como na eliminação dos sintomas presentes no pós-cirúrgico e na conscientização dos hábitos deletérios, que são apontados pela literatura como possíveis fatores desencadeantes.AIM: the aim of this study was to describe miofunctional oral intervention in patients with Masseter muscle hipertrophy treated by surgery. METHODS: the sample consisted of 4 patients, male and female, with ages between 16 and 24 years, with Masseter muscle hipertrophy treated by surgery. RESULTS: the main complains on the postoperative were related to trismus, muscle rigidity, and clicking in the temporomandibular joint. The myofunctional oral therapy was based on orientation in the abnormal habits (bruxism, clenching elimination, hyperthermia induced in the masseter muscle, oral muscles massage, facial and cervical muscles stretching, miofunctional exercises and

  7. Ação do radium sôbre o vírus da Coriomeningite linfocitária benigna Radium effect upon the lymphocytic choriomeningitis virus

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    J. Guilherme Lacorte

    1968-01-01

    Full Text Available O presente trabalho faz parte de uma seqüência iniciada em 1953 com a verificação do efeito dos raios X sôbre o vírus da gripe em que observamos que os mesmos, em doses fracas, tem aumentado o seu poder patogênico para camundongos. Posteriormente, verificamos a ação do radium sôbre o vírus da gripe e da poliomielite. Neste último caso, o vírus irradiado mostrou-se ativo durante maior número de dias. Nas pesquisas aqui referidas, submetemos o vírus da coriomeningite linfocitária benigna a ação do radium, usando quatro agulhas de 1 mg desse elemento em dispositivo que idealizamos para êste fim. Depois de irradiada, foi a suspensão de vírus diluida a 10*-1, 10*-2 e 10*-3 para as inoculações em camundongos, juntamente com as diluições testemunhas. Observamos que o vírus resistiu pelo menos 264 dias, à temperatura de 4ºC. Quanto às alterações do poder patogênico provocadas pelo radium verificamos que o mesmo não se altera após 24 horas de irradiação. Diminue após 8 dias para aumentar, de modo seguro, após 20 e 33 dias. Iguala-se ao testemunha depois de 78 dias.In the present paper the authors refered the experiments made with the lymphocytic chriomeningitis virus. We strain, after exposition to 4 tubes of 1 mg of radium. The virus suspension was put into the Carrel flask in a layer of 0,1 cm. The titrations of the irradiated virus suspension were made after 24 hours, 8, 20, 33, 78, 85, 120, 264, 292, 387 and 535 days. the virus was still active after 264 days, not after 292 days. The virus irradiated during 24 hours presented the same pathogenicity form mice than the control but after 8 days it was lesser and after 20 and 33 days it was enchanced (Graphic 10. After 78 days the pathogenic power was the same for the irradiated virus and the control.

  8. Partial Oxidation of Methane to Synthesis Gas over Hexaaluminates LaMAl11O19-δ catalysts

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    A series of M-substituted hexaaluminates LaMAl11O19-δ (M=Fe, Co, Ni, Mn, and Cu)were prepared and characterized by XRD, XPS, TPR and TGA techniques, respectively. They exhibited different reducibility and catalytic activity for partial oxidation of methane (POM) to synthesis gas. Among the LaMAl11O19-δ samples, LaNiAl11O19-δ showed the best catalytic activity for the topic reaction and selectivity for synthesis gas at 780 ℃ for 2 h. The conversion of CH4 was over 99.2%, and the product selectivity for both CO and H2 was above 90.3%.

  9. First successful reduction of clinical allergenicity of food by genetic modification: Mal d 1-silenced apples cause fewer allergy symptoms than the wild-type cultivar

    DEFF Research Database (Denmark)

    Dubois, A. E. J.; Pagliarani, G.; Brouwer, R. M.;

    2015-01-01

    BACKGROUND: Genetic modification of allergenic foods such as apple has the potential to reduce their clinical allergenicity, but this has never been studied by oral challenges in allergic individuals. METHODS: We performed oral food challenges in 21 apple-allergic individuals with Elstar apples...... which had undergone gene silencing of the major allergen of apple, Mal d 1, by RNA interference. Downregulation of Mal d 1 gene expression in the apples was verified by qRT-PCR. Clinical responses to the genetically modified apples were compared to those seen with the wild-type Elstar using a visual...... analogue scale (VAS). RESULTS: Gene silencing produced two genetically modified apple lines expressing Mal d 1.02 and other Mal d 1 gene mRNA levels which were extensively downregulated, that is only 0.1-16.4% (e-DR1) and 0.2-9.9% (e-DR2) of those of the wild-type Elstar, respectively. Challenges...

  10. « Les fleurs du MAL » une méthode d'ondelettes adaptive de lignes arbitraires I : problèmes de convection diffusion

    Science.gov (United States)

    Ren, Xiaoan; Xanthis, Leonidas S.

    2004-01-01

    Baudelaire's 'les fleurs du mal' refers to various new developments ('les fleurs') of the method ofarbitrarylines ( mal), since it was first published (in C. R. Acad. Sci. Paris, Sér. I, in 1991). Here we revisit the basic mal (semi-discretization) methodology for stationary convection-diffusion problems and develop an adaptive, wavelet-based solver that is capable of capturing the thin layers that arise in such problems. We show the efficacy and high accuracy of the wavelet-mal solver by applying it to a challenging 2D problem involving both boundary and interior layers. To cite this article: X. Ren, L.S. Xanthis, C. R. Mecanique 332 (2004).

  11. Malária por Plasmodium falciparum: estudos proteômicos Plasmodium falciparum malaria: proteomic studies

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    Rodrigo Siqueira-Batista

    2012-12-01

    Full Text Available A despeito dos avanços no tratamento e das campanhas de prevenção e de controle da malária nos distintos continentes nos quais a moléstia grassa, a entidade mórbida permanece com significativa relevância no mundo contemporâneo. O Plasmodium falciparum é o grande responsável pela malária grave, caracterizada por distúrbios em diferentes órgãos e sistemas, com possibilidade de evolução ao óbito. Embora incipientes, os estudos proteômicos na malária têm trazido boas perspectivas para melhor compreensão dos aspectos biológicos do Plasmodium, assim como dos mecanismos fisiopatológicos, diagnósticos, terapêuticos e profiláticos da enfermidade. Desse modo, o objetivo do presente artigo é apresentar uma breve revisão das aplicações da análise proteômica na malária por P. falciparum.Despite advances in treatment and campaigns for prevention and control of malaria on the various continents where it is still rampant, this disease remains significantly relevant to the contemporary world. Plasmodium falciparum is the organism that is mainly responsible for severe malaria, which is characterized by disturbances in different organs and systems, with possibly fatal outcomes. Although incipient, proteomic studies of malaria have yielded favorable prospects for elucidating the biological aspects of Plasmodium as well as the pathophysiological, diagnostic, prophylactic, and therapeutic mechanisms of the disease. Thus, the aim of the present article is to present a brief review of the applications of proteomic analysis in P. falciparum malaria.

  12. Quema de libros y antitotalitarismo. Manuel Rivas Los libros arden mal y Ray Bradbury Fahrenheit 451

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    Mechthild Albert

    2016-07-01

    Full Text Available El presente artículo se propone comparar dos novelas cuyo común denominador es el compromiso antitotalitario con motivo de la quema de libros considerada como el culmen de la barbarie anticultural, a saber Los libros arden mal (2006 de Manuel Rivas y Fahrenheit 451 (1953 de Ray Bradbury. Partiendo de las reflexiones de Fernando Rodríguez de la Flor en torno al biblioclasmo (2004, el paralelo se centra en los siguientes aspectos: la descripción zoo- y antropomorfizada de los libros en llamas; el biblioclasmo como expresión del totalitarismo, denotando asimismo una relación ambivalente y dialéctica entre cultura y barbarie; los movimientos subversivos dedicados a mantener el culto al libro y la tradición filosófico-literaria; la intertextualidad y el papel destacado de la Biblia en cuanto Libro de los libros. En conclusión se podrá constatar que, a pesar de numerosos puntos en común, en particular su compromiso antitotalitario, ambos autores se distinguen en concreto por su orientación política y el enfoque de su crítica cultural

  13. Santa Clara de Nanay: the MAL-ED cohort in Peru.

    Science.gov (United States)

    Yori, Pablo Peñataro; Lee, Gwenyth; Olórtegui, Maribel Paredes; Chávez, César Banda; Flores, Julian Torres; Vasquez, Angel Orbe; Burga, Rosa; Pinedo, Silvia Rengifo; Asayag, César Ramal; Black, Robert E; Caulfield, Laura E; Kosek, Margaret

    2014-11-01

    The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) cohort study communities in Peru are located in Loreto province, in a rural area 15 km from the city of Iquitos. This riverine population of approximately 5000 individuals is fairly representative of Loreto. The province lags behind the rest of the country in access to water and sanitation, per capita income, and key health indicators including infant mortality (43.0 vs 16.0 per 1000 nationwide) and under-5 mortality (60.6 vs 21.0 per 1000). Total fertility rates are higher than elsewhere in the country (4.3 vs 2.6). Nationwide, the prevalence of human immunodeficiency virus is estimated at 0.45%, the prevalence of tuberculosis is 117 per 100 000, and the incidence of malaria is 258 per 100 000. Stunting in this community is high, whereas acute undernutrition is relatively uncommon. The population suffers from high rates of diarrheal disease. Prevalent enteric pathogens include Ascaris, Giardia, enterotoxigenic Escherichia coli, Shigella, and Campylobacter.

  14. Synthesis and Crystal Structure of a Macrocycle [Cu(dadm)(mal)(H2O)]2·2H2O

    Institute of Scientific and Technical Information of China (English)

    林郑忠; 江飞龙; 陈莲; 洪茂椿

    2004-01-01

    The reaction of 4,4′-diaminodiphenylmethane (dadm), malonic acid (H2mal) and Cu(NO3)2 in aqueous solution results in a discrete binuclear Cu(II) macrocycle: [Cu(dadm)(mal)- (H2O)]2(2H2O. It crystallizes in monoclinic, space group P21/c with a = 15.231(3), b = 11.847(2), c = 9.801(2)A,Z= 106.75(3)o, V = 1693.5(6)A3, Z = 2, C32H40Cu2N4O12, Mr = 799.76, Dc = 1.568 g/cm3, λ(MoK() = 0.71073A, μ = 1.325 mm-1, F(000) = 828, the final R = 0.0531 and Wr = 0.1244 for 3421 observed reflections with I > 2σ(I). Each Cu(II) is coordinated by two oxygen atoms from a mal ligand, two nitrogen atoms from two dadm ligands and a water oxygen atom to form a triangle bipyramidal motif. The title compound possesses a distorted macrocycle enclosed by dadm with approximate dimensions of 8.3A× 5.9A.

  15. Malé a střední jaderné reaktory a jejich využití

    OpenAIRE

    Novotný, Filip

    2012-01-01

    Bakalářská práce se zaměřuje na oblast malých a středních jaderných reaktorů, na jejich roli při počátečním vývoji jaderné energetiky. Shrnuje současné malé a střední reaktory v provozu a zamýšlí se nad budoucím vývojem v této oblasti. Analyzuje možnosti jejich využití a aplikace v různých oblastech lidské činnosti. Soustředí se na nové projekty malých a středních reaktorů, s důrazem na projekty dostupné v nejbližší době. Hodnotí odolnost proti šíření jaderných zbraní, ekonomické a technické ...

  16. Synthesis and Crystal Structure of a Novel 2D Coordination Polymer [Cu3(mal)2(di-2-pyridlyktone)2

    Institute of Scientific and Technical Information of China (English)

    ZHANG Mei-Li; WU Ya-Pan; WANG Ji-Jiang; REN Yi-Xia; CHEN Xiao-Li

    2011-01-01

    A novel coordination polymer of CuⅡ with flexible ligands, namely, [Cu3(mal)2(di2-pyridlyktone)2] (1, H2mal = maleie acid), was synthesized and characterized by single-crystal X-ray diffraction, thermogravimetric analyses, elemental analysis and IR spectroscopy. The structure indicates that the complex crystallizes in monoclinic, space group P21/c with a = 10.268(2), b =17.737(3), c = 8.038(1) (A), β = 98.275(2)°, V = 1448.6(4) (A)3, Z = 2, Dc = 1.883 Mg·m-3, μ = 2.260 mm-1, F(000) = 826, and the final R = 0.0321 and wR = 0.0820. In 1, three CuⅡ centers (Cu(1),Cu(2), Cu(1A)) are bridged by two uncommonμ3-bridging H2mal ligands, furnishing a centrosymmetric trimetallic unit. Via further Cu-Ocoo coordination interactions, extention of these trimetallic units in two directions gives rise to an infinite corrugated 2D layer. In addition, thermal stability and electrochemistry of 1 were studied.

  17. Comparison of measles complications in well nourished and mal-nourished children

    International Nuclear Information System (INIS)

    Measles is the most common and the most infectious of the viral infections of childhood. It can cause severe pneumonia, diarrhoea, encephalitis, and death. A significant proportion of deaths due to measles in young children worldwide are attributable to low weight for age. To compare the measles complications in well-nourished and mal-nourished children, this cross-sectional study was conducted at Paediatric out-patient department and paediatric unit 1 Bahawal Victoria Hospital Bahawalpur. Total 120 patients were included in the study. All patients presented with signs and symptoms suggestive of measles according to WHO criteria. These patients were divided into well nourished and malnourished according to the modified Gomez classification. Both groups were evaluated for measles complications like pneumonia, diarrhoea, encephalitis, corneal ulceration, thrombocytopenia, otitis media and myocarditis by detailed history and complete physical examination, and statistically analysed. In the studied patients, 75 were males and 45 were females. Mean age was 23 months. Fifty-nine (49.2%) patients were well-nourished and 61 (50.8%) were undernourished. Fifty-two (43.3%) patients were having pneumonia. Fifty-three (44.2%) patients were having diarrhoea. Twenty-six (21.7%) patients were having encephalitis. Corneal ulceration was found in 9 (7.5%) patients. Thrombocytopenia and otitis media was present in 1 patient in each group. Fourteen patients expired. Measles is a global epidemic problem having many serious complications, including pneumonia, diarrhoea, encephalitis, corneal ulcerations etc. Moreover these complications are more frequent in under nourished children. Efforts should be made to improve the nutritional status of the children and to eradicate this disease by effective vaccination. (author)

  18. MalHaploFreq: A computer programme for estimating malaria haplotype frequencies from blood samples

    Directory of Open Access Journals (Sweden)

    Smith Thomas A

    2008-07-01

    Full Text Available Abstract Background Molecular markers, particularly those associated with drug resistance, are important surveillance tools that can inform policy choice. People infected with falciparum malaria often contain several genetically-distinct clones of the parasite; genotyping the patients' blood reveals whether or not the marker is present (i.e. its prevalence, but does not reveal its frequency. For example a person with four malaria clones may contain both mutant and wildtype forms of a marker but it is not possible to distinguish the relative frequencies of the mutant and wildtypes i.e. 1:3, 2:2 or 3:1. Methods An appropriate method for obtaining frequencies from prevalence data is by Maximum Likelihood analysis. A computer programme has been developed that allows the frequency of markers, and haplotypes defined by up to three codons, to be estimated from blood phenotype data. Results The programme has been fully documented [see Additional File 1] and provided with a user-friendly interface suitable for large scale analyses. It returns accurate frequencies and 95% confidence intervals from simulated dataset sets and has been extensively tested on field data sets. Additional File 1 User manual for MalHaploFreq. Click here for file Conclusion The programme is included [see Additional File 2] and/or may be freely downloaded from 1. It can then be used to extract molecular marker and haplotype frequencies from their prevalence in human blood samples. This should enhance the use of frequency data to inform antimalarial drug policy choice. Additional File 2 executable programme compiled for use on DOS or windows Click here for file

  19. Early interruption of exclusive breastfeeding: results from the eight-country MAL-ED study.

    Science.gov (United States)

    Patil, Crystal L; Turab, Ali; Ambikapathi, Ramya; Nesamvuni, Cebisa; Chandyo, Ram Krishna; Bose, Anuradha; Islam, M Munirul; Ahmed, A M Shamsir; Olortegui, Maribel Paredes; de Moraes, Milena Lima; Caulfield, Laura E

    2015-01-01

    We report the infant feeding experiences in the first month of life for 2,053 infants participating in "Malnutrition and Enteric Infections: Consequences for Child Health and Development" (MAL-ED). Eight sites (in Bangladesh, India, Nepal, Pakistan, Brazil, Peru, South Africa, Tanzania), each followed a cohort of children from birth (by day 17), collecting detailed information on infant feeding practices, diet and illness episodes. Mothers were queried twice weekly regarding health status, breastfeeding and the introduction (or no) of non-breast milk liquids and foods. Here, our goal is to describe the early infant feeding practices in the cohort and evaluate factors associated with termination of exclusive breastfeeding in the first month of life. With data from enrollment to a visit at 28-33 days of life, we characterized exclusive, predominant or partial breastfeeding (using a median of 6-9 visits per child across the sites). Only 6 of 2,053 infants were never breastfed. By one month, the prevalences of exclusive breastfeeding were  20% in 6 of 8 sites. Logistic regression revealed that prelacteal feeding (given to 4-63% of infants) increased the likelihood of partial breastfeeding (Odds Ratio (OR): 1.48 (95% confidence interval (CI): 1.04, 2.10), as did the withholding of colostrum (2-16% of infants) (OR: 1.63:1.01, 2.62), and being a first-time mother (OR: 1.38:1.10, 1.75). Our results reveal diversity across these sites, but an overall trend of early transition away from exclusive breastfeeding in the first month of life. Interventions which introduce or reinforce the WHO/UNICEF Ten Steps for Successful Breastfeeding are needed in these sites to improve breastfeeding initiation, to reinforce exclusive breastfeeding and delay introduction of non-breast milk foods and/or liquids. PMID:26825923

  20. Readaptation of the Vestibulo-Ocular Reflex Relieves the Mal de Debarquement Syndrome

    Directory of Open Access Journals (Sweden)

    Mingjia eDai

    2014-07-01

    Full Text Available The Mal de Debarquement Syndrome (MdDS, a continuous feeling of swaying, rocking and/or bobbing, generally follows travel on the sea. The associated symptoms cause considerable distress. The underlying neural mechanisms are unknown, and to date there have been no effective treatments for this condition. Results in monkeys and humans suggested that MdDS was caused by maladaptation of the vestibulo-ocular reflex (VOR to roll of the head during rotation. We studied twenty-four subjects with persistent MdDS (3 males, 21 females; 19.1 ± 33 months. Physical findings included body oscillation at 0.2Hz, oscillating vertical nystagmus when the head was rolled from side-to-side in darkness, and unilateral rotation during the Fukuda stepping test. We posited that the maladapted rocking and the physical symptoms could be diminished or extinguished by readapting the VOR. Subjects were treated by rolling the head from side-to-side while watching a rotating full-field visual stimulus. Seventeen of the twenty-four subjects had a complete or substantial recovery on average for approximately one year. Six were initially better, but the symptoms recurred. One subject did not respond to treatment. Thus, readaptation of the VOR has led to a cure or substantial improvement in 70% of the subjects with MdDS. We conclude that the adaptive processes associated with roll-while-rotating are responsible for producing MdDS, and that the symptoms can be reduced or resolved by readapting the VOR.

  1. Readaptation of the vestibulo-ocular reflex relieves the mal de debarquement syndrome.

    Science.gov (United States)

    Dai, Mingjia; Cohen, Bernard; Smouha, Eric; Cho, Catherine

    2014-01-01

    The mal de debarquement syndrome (MdDS), a continuous feeling of swaying, rocking, and/or bobbing, generally follows travel on the sea. The associated symptoms cause considerable distress. The underlying neural mechanisms are unknown, and to date there have been no effective treatments for this condition. Results in monkeys and humans suggested that MdDS was caused by maladaptation of the vestibulo-ocular reflex (VOR) to roll of the head during rotation. We studied 24 subjects with persistent MdDS (3 males, 21 females; 19.1 ± 33 months). Physical findings included body oscillation at 0.2 Hz, oscillating vertical nystagmus when the head was rolled from side-to-side in darkness, and unilateral rotation during the Fukuda stepping test. We posited that the maladapted rocking and the physical symptoms could be diminished or extinguished by readapting the VOR. Subjects were treated by rolling the head from side-to-side while watching a rotating full-field visual stimulus. Seventeen of the 24 subjects had a complete or substantial recovery on average for approximately 1 year. Six were initially better, but the symptoms recurred. One subject did not respond to treatment. Thus, readaptation of the VOR has led to a cure or substantial improvement in 70% of the subjects with MdDS. We conclude that the adaptive processes associated with roll-while-rotating are responsible for producing MdDS, and that the symptoms can be reduced or resolved by readapting the VOR.

  2. Simulação no contexto de problemas mal estruturados

    Directory of Open Access Journals (Sweden)

    Antônio Sérgio de Souza

    1994-12-01

    Full Text Available Simulação é atualmente reconhecida como uma poderosa ferramenta no projeto, análise e operação de sistemas produtivos. Apesar dos avanços recentes em linguagens de simulação, interfaces gráficas e geradores de aplicações, simulação ainda é uma técnica cara e pouco eficiente. Discute-se no texto algumas causas deste fato no contexto de problemas mal estruturados, como é o caso de planejamento e controle da produção. Discute-se a necessidade de realização da modelagem conceitual, não apenas como um passo estanque no processo de simulação, mas de forma progressiva e dinâmica, durante todo o ciclo de vida do projeto, servindo como uma interface entre os contextos real e de simulação.Simulation is now recognized as powerful tool in project, analyses and operation of produtive systems. Although the recent advances in simulation languages, graphical interfaces and in generating applications, simulation is still an expensive and not so efficient technique. In this text we dicuss some reasons for this in the context of not well strutured problems, asit is the case of production planning and control. It is also dicussed the necessity of developing the conceptual modeling of the real system, not only as a separated step in the simulation process, but in a progressive and dynamic way, during the project's life cycle as an interface between the real system and simulation.

  3. Comprometimento pulmonar na malária (revisão Pulmonary involvement in malaria

    Directory of Open Access Journals (Sweden)

    Marcos Boulos

    1993-02-01

    Full Text Available Com uma incidência de 3 a 10% dos casos e letalidade próxima a 70%, o comprometimento pulmonar constitui uma das manifestações mais graves da malária por Plasmodium falciparum. Embora sua patogênese não esteja perfeitamente esclarecida, reconhece-se que a hiperativação do sistema imune por antígenos liberados pelo Plasmodium falciparum desempenhe um importante papel no desencadeamento e agravamento das lesões. A estrutura alvo parece ser o endotélio capilar, responsável pelo fluxo de líquidos para o espaço intersticial. Essas células são ativadas por ação de citocinas, produzidas por linfócitos e macrófagos durante a resposta imune, e passam a expressar em sua membrana celular receptores e moléculas de aderência que facilitam a sequestração de eritrócitos parasitados e também a aderência de células capazes de produzir mediadores inflamatórios. A reação inflamatória e a lesão endotelial que se seguem, juntamente com as alterações hemodinâmicas induzidas pelo bloqueio capilar devido ao acúmulo local de eritrócitos e células inflamatórias causam alterações de permeabilidade vascular e, consequentemente, acúmulo de líquido nos espaços intersticiais e alvéolos. Nos casos mais graves, as manifestações clínicas assemelham-se às do quadro da Síndrome do desconforto respiratório do adulto. Comprometimento pulmonar grave pode se instalar rapidamente em qualquer estágio da evolução clínica da malária, mesmo após a cura parasitológica, desconhecendo-se os fatores desencadeantes. Hiperparasitismo, insuficiência renal e gravidez constituem fatores predisponentes. O prognóstico dependerá da rapidez com que o diagnóstico for estabelecido e o correto tratamento instituído. Além do tratamento instituído contra o parasita, especial atenção deverá ser dispensada à monitorização hemodinâmica, se possível através de cateter de Swan-Ganz, à manutenção de adequada oxigenação e balanço h

  4. Endocrinopatías en gatos diagnosticadas entre marzo de 2003 y marzo de 2011 en el Hospital Escuela de Medicina Veterinaria de la Facultad de Ciencias Veterinarias, Universidad de Buenos Aires Endocrinopathies in cats diagnosed between March 2003 and March 2011 in the Veterinary school Hospital, Faculty of Veterinary Science, University of Buenos Aires

    OpenAIRE

    M.M Zapata; Castillo, V A

    2011-01-01

    El objetivo de este estudio fue analizar la frecuencia de presentación de endocrinopatías diagnosticadas en la Unidad de Endocrinología del Hospital Escuela en el período comprendido entre marzo de 2003 y marzo de 2011. Se revisaron las historias clínicas de 40 gatos diagnosticados con diversas endocrinopatías. La diabetes mellitus representó el 47,5% (19/40) de los casos, el hipertiroidismo el 20% (8/40), el hipotiroidismo el 15% (6/40) y el SC el 10% (4/40), siendo los desórdenes endócrinos...

  5. Efeito da manobra de Epley na qualidade de vida dos pacientes com vertigem posicional paroxística benigna Effect of Epley's maneuver on the quality of life of paroxismal positional benign vertigo patients

    Directory of Open Access Journals (Sweden)

    Alcione Botelho Pereira

    2010-12-01

    Full Text Available A vertigem produz impactos significativos na qualidade de vida (QV. É necessário mensurar os efeitos das terapêuticas antivertiginosas na QV. OBJETIVO: Investigar o efeito da manobra de reposicionamento na qualidade de vida de pacientes com vertigem posicional paroxística benigna (VPPB. MATERIAL E MÉTODOS: Estudo retrospectivo, através da revisão dos prontuários de 21 pacientes com VPPB atendidos no serviço de Reabilitação Vestibular (RV de uma clínica escola de Belo Horizonte atendidos em 2007-2008. Foram analisados os escores físicos, funcionais e emocionais, pré e pós-terapia de RV com realização de manobras de reposicionamento de Epley, por meio do questionário Dizziness Handicap Inventory (DHI, específico para avaliação da interferência da tontura na QV. RESULTADOS: O intervalo mediano entre as avaliações foi de 21 dias. O número médio de manobras foi 2,3±1,1. A aplicação do DHI mostrou um significante impacto da VPPB na QV dos pacientes em todas as dimensões da vida diária, com os seguintes escores médios pré e pós-terapia: físico (17,5/3,7, funcional (17,3/3,9, emocional (13,2/3,2 e total (48,1/10,9, respectivamente (pQuality of life (QoL is significantly impaired by vertigo. The effect of specific treatments on QoL deserves investigation. AIM: To assess the effect of repositioning maneuvers on the QoL of benign paroxysmal positioning vertigo (BPPV patients. MATERIALS AND METHODS: A retrospective study design consiting of reviews of charts of BPPV patients in a vestibular rehabilitation unit at a teaching institution in Belo Horizonte, MG, Brazil, from 2007 to 2008. Pre- and post-therapy (Epley's repositioning maneuver scores on the physical, functional and emotional dimensions of the Dizziness Handicap Inventory (DHI were analyzed. RESULTS: Twenty-one patients were included, eighteen (86% were females; the average age was 53.2 years. Ten patients presented bilateral BPPV; in eleven it was unilateral

  6. Estenoses biliares benignas: reparação e resultados com o uso de silastic transhepático transanastomótico Benign biliary strictures: repair and outcome with the use of silastic transhepatic transanastomotic stents

    Directory of Open Access Journals (Sweden)

    José Artur Sampaio

    2010-12-01

    Full Text Available RACIONAL: Os avanços da medicina nem sempre estão relacionados a bons resultados homogêneos para todos os pacientes. Este é o caso de colecistectomia laparoscópica, cujas vantagens são amplamente reconhecidos na literatura médica. No entanto, ela pode trazer consigo temida e grave complicação que é lesão iatrogênica da via biliar extra-hepática. Ela vem aumentando nos últimos anos, apesar da curva de aprendizagem já estar ultrapassada na maioria dos centros. Está estabilizada em nível mais elevado do que o registrado nas colecistectomias laparotômicas. Na reparação das grandes lesões bom resultado pode ser alcançado com a utilização de tubos transanastomóticos em associação à hepaticojejunostomias. OBJETIVOS: Relatar 20 anos de experiência na reconstrução das vias biliares por lesão ductal com o uso de tubos transanastomóticos. MÉTODOS: Foram analisados os dados de 338 pacientes que se submeteram à operação para as principais lesões do ducto biliar entre janeiro de 1988 e dezembro de 2009. RESULTADOS: Todos os 338 pacientes foram submetidos à hepaticojejunostomias com anastomoses em Y-de-Roux (Hepp-Couinaud ou colangiojejunostomias, todos com o uso de tubos de silastic transanastomóticos. A longo prazo, bom resultado foi obtido em 240 (92,9% dos 338 pacientes, incluindo aqueles que necessitaram de procedimentos subsequentes. CONCLUSÃO: Estenoses biliares benignas próximas à confluência dos ductos hepáticos permanece sendo desafio cirúrgico. O uso de tubos de silastic transhepáticos transanastomóticos na reconstrução biliar alta é opção que pode proporcionar boa reparação biliar com baixos índices de complicações.BACKGROUND: The medical advances is not always related to homogeneous good results for all the patients. This is the case of laparoscopic cholecystectomy, whose advantages are largely recognized in the medical literature. However, this operation most dreaded complication

  7. Variáveis reprodutivas e risco para doenças benignas de mama: estudo caso-controle Reproductive variables and risk of benign breast diseases: a case-control study

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    Ellen E. Hardy

    1990-10-01

    Full Text Available Foram estudadas 257 mulheres com diagnóstico de doença benigna de mama (DBM, atestado por anatomopatológico ou citologia, e um controle para cada uma delas. Foram apresentados resultados das possíveis relações entre variáveis reprodutivas e o risco para DBM. Os casos e controles foram comparados levando em conta a idade na menarca e na menopausa, o número de gravidezes, de meses em que amamentaram e de ciclos menstruais ovulatórios, e os antecedentes familiares de câncer de mama. Mostraram influência significativa, em relação às DBM, a nuliparidade, aumentando o risco enquanto a idade de 30 ou mais anos no primeiro parto o reduziu; o número de ciclos ovulatórios, que foi significativamente maior para os casos, e a média de meses de uso de pílula, menor entre as mulheres com DBM. O uso de contraceptivos orais apresentou um efeito protetor apenas quando a duração total do uso foi maior que dois anos. Os resultados não se revelaram novos ou diferentes se comparados com outros estudos, mas confirmam a relativa concordância entre os fatores de risco para DBM e para câncer de mama, ainda que as relações entre esses fatores e as DBM não sejam tão claras como o são para o câncer, e existam também algumas discrepâncias.The purpose of the study was the identification of risk factors for benign breast diseases (BBD; 257 women with BBD diagnosed through pathological anatomy or citology and a matched control for each were studied. Subjects were selected at The State University of Campinas Hospital and at a private clinic. To enter the study cases had to have a first diagnosis of BBD between October 1979 and August 1984. The following BBD were considered: dysplasia, fibroadenoma, cystic disease, papilloma and ductal ectasia. Reproductive variables were studied as risk factors, including menstrual ovulatory cycles. The date on which the BBD was diagnosed was defined as the index date. For controls, data were considered up to when

  8. Malária pulmonar: aspectos na tomografia computadorizada de alta resolução - relato de caso

    Directory of Open Access Journals (Sweden)

    Rodrigues Rosana

    2004-01-01

    Full Text Available Neste trabalho é relatado o caso de paciente do sexo masculino, de 38 anos de idade, que desenvolveu quadro de malária com comprometimento pulmonar. A tomografia computadorizada de alta resolução evidenciou espessamento de septos interlobulares e de bainhas peribroncovasculares, com áreas esparsas de atenuação em vidro fosco e de consolidações, além de derrame pleural bilateral, aspectos compatíveis com edema pulmonar. O paciente recebeu tratamento específico, evoluindo bem e tendo alta 11 dias após a internação.

  9. Malária pulmonar: aspectos na tomografia computadorizada de alta resolução - relato de caso

    OpenAIRE

    Rodrigues Rosana; Marchiori Edson; Souza Daniel Andrade Tinoco de

    2004-01-01

    Neste trabalho é relatado o caso de paciente do sexo masculino, de 38 anos de idade, que desenvolveu quadro de malária com comprometimento pulmonar. A tomografia computadorizada de alta resolução evidenciou espessamento de septos interlobulares e de bainhas peribroncovasculares, com áreas esparsas de atenuação em vidro fosco e de consolidações, além de derrame pleural bilateral, aspectos compatíveis com edema pulmonar. O paciente recebeu tratamento específico, evoluindo bem e tendo alta 11 di...

  10. 有多少双眼睛盯着你对电脑心怀不轨的MalWare们

    Institute of Scientific and Technical Information of China (English)

    冯磊

    2005-01-01

    @@ 今天,用病毒代表那些对计算机具有破坏性和恶意企图的软件已经不合时宜,因为虎视眈眈看着我们的计算机系统的软件决不只有病毒.现在计算机人员给那些对电脑产生危害的软件起了一个通用的名字,它叫做MalWare(恶意软件).

  11. Memorias en voz baja. Transmisión oral intergeneracional: de Os libros arden mal a As voces baixas

    Directory of Open Access Journals (Sweden)

    Mariela Sánchez

    2016-07-01

    Full Text Available This paper analyzes the way a transfer of past traumatic experience involves two texts by Manuel Rivas in which acquires prominence oral discourse. The Spanish Civil War and its consequences are incorporated into Os libros arden mal and As voces baixas narrative with special emphasis on the generations that did not live those years. The convergence between orality and literacy are fertile ground for considering the inclusion of long-neglected voices because of forced silences and because of the suppression of truths that took a long time to become visible

  12. Situação da malária na tríplice fronteira entre Brasil, Colômbia e Peru

    Directory of Open Access Journals (Sweden)

    Paulo César Peiter

    2013-12-01

    Full Text Available O objetivo deste artigo é analisar a situação da vigilância da malária na tríplice fronteira entre Brasil, Colômbia e Peru. É um estudo qualitativo com aplicação de questionários em cidades da fronteira realizado em 2011. Os resultados foram analisados pela metodologia DOFA e apontaram diferenças significativas entre os sistemas de vigilância da malária na fronteira. Observou-se como debilidades a desarticulação entre atores responsáveis, a insuficiência de pessoal treinado, a alta rotatividade das equipes e a falta de médicos especialistas em malária nos hospitais locais. Verificou-se ainda o desconhecimento sobre a malária e suas formas de prevenção na população entrevistada. As fortalezas são a inserção de novos atores institucionais, a melhora da qualificação profissional, a distribuição de mosquiteiros impregnados e possibilidades de complementaridade entre os sistemas de vigilância a serem aproveitadas pela cooperação entre as equipes de saúde da fronteira, pois o controle da malária só pode ter sucesso tomando-se esta região em seu conjunto.

  13. Tuberculose ostéoarticulaire (mal de Pott exclu): à propos de 120 cas à Abidjan

    Science.gov (United States)

    Gbané-Koné, Mariam; Koné, Samba; Ouali, Boubacar; Djaha, Kouassi Jean -Mermoz; Akoli, Ekoya Ondzala; Nseng, Ingrid Nseng; Eti, Edmond; Daboiko, Jean Claude; Touré, Stanislas André; Kouakou, N'zué Marcel

    2015-01-01

    Introduction La tuberculose ostéoarticulaire (TOA) représente 2 à 5% de l'ensemble des tuberculoses. Elle demeure d'actualité surtout dans les pays à forte endémicité tuberculeuse. L'objectif était de déterminer la prévalence, les aspects topographiques, radiologiques de la TOA en milieu hospitalier ivoirien. Méthodes Les auteurs rapportent une expérience de 11 ans, à travers une étude rétrospective de 120 dossiers de patients atteints de la tuberculose ostéoarticulaire (le mal de Pott est exclu de cette étude). N'ont pas été inclus dans l’étude les dossiers ne comportant pas d'imagerie. Résultats L'atteinte extra vertébrale représentait 09,2% de la tuberculose ostéoarticulaire. Il s'agissait de 54 hommes et 66 femmes, l’âge moyen était de 43,13 ans. On notait 123 cas d'ostéoarthrites, et 8 cas d'ostéites des os plats. L'atteinte des membres inférieurs prédominait dans 91,87% des cas. La hanche était la première localisation (45,04%), suivie du genou (25,19%). Les atteintes étaient multifocales dans 20% des cas. L'atteinte osseuse était associée à une tuberculose pulmonaire dans 05,83% des cas. Des localisations inhabituelles ont été rapportées: poignet (n = 2), branches ischiopubiennes (n = 4), atteinte sternoclaviculaire (n = 4), médiopieds (n = 2). Les lésions radiologiques étaient avancées (stades III et IV) dans 55,73% des cas. A la TDM, la prévalence des abcès était de 77%. Un geste chirurgical a été réalisé sur 16 articulations (2 épaules, 13 genoux, une cheville). Conclusion La TOA des membres est peu fréquente contrairement à l'atteinte vertébrale. La hanche est la principale localisation. Le retard au diagnostic explique l’étendue des lésions anatomoradiologiques. PMID:26587129

  14. 配位聚合物{[Zn(TSC)(MAL)]·H2O}n的制备及结构表征%Preparation and Structure Characterization of Coordination Polymer:{[Zn(TSC)(MAL)]·H2O}n

    Institute of Scientific and Technical Information of China (English)

    李胜利; 吴杰颖; 田玉鹏; Fun Hoong Kun

    2006-01-01

    The novel Zn Ⅱ complex, {[Zn(TSC)(MAL)] ·H2O}n (1), where TSC is thiosemicarbazide and MAL is malonate radicle), was synthesized by self-assembling from the reaction of stoichiometric zinc chloride, thiosemicarbazide and malonic acid in solution at pH 4.5~5.0. The structural and physicochemical properties were characterized by X-ray diffraction, infrared spectroscopy, electronic spectra and thermal analysis. The crystal data for the title coordination polymer: Monoclinic, P21/c, β3=107.808(1)°, a=0.937 59(1) nm, b=l.110 83(1) nm, c=0.921 00 (2) nm, Z=2, μ=2.919 mm-1, R1=0.039 0, wR2=0.099 4. The structure feature is that the bridging dicarboxylates effectively link the zinc centers to form polymeric chain in a zig-zag way, which is stabilized by

  15. Effects of mal62-overexpression on leavening ability of baker's yeast%mal62基因高表达对工业面包酵母发酵力的影响

    Institute of Scientific and Technical Information of China (English)

    孙溪; 张翠英; 董建; 王光路; 吴鸣月; 肖冬光

    2012-01-01

    [目的]构建高麦芽糖利用能力的面包酵母菌株,以期提高面包酵母在不加糖面团中的发酵力,增加经济效益的同时减少成本消耗.[方法]克隆工业面包酵母BY-14的麦芽糖酶基因mal62,以PGKl强启动子和终止子为调控元件,以酵母-大肠穿梭型质粒Yep-C为载体,构建重组表达质粒Yep-CPM,并转化酿酒酵母(Saccharomyces cerevisiae)BY-14,经筛选鉴定获得酵母转化子BYCPM.进行转化子的酶活力、mal62基因表达水平及发酵力测定,检测目的基因的功能性表达.[结果]工业酵母转化子BYCPM的最大麦芽糖酶活力比对照菌提高15% -52%,发酵力提高40%,比发酵力提高5.6%.[结论]转化子BYCPM具有更高的麦芽糖酶活力和更强的抗葡萄糖阻遏能力.并且在不加糖面团中,转化子具有更高的发酵力,可以在更短的时间内获得更大的产气量且消耗更少的碳源.%[Objective] To increase the leavening ability in the lean dough, the maltose utilization ability of baker's yeast was enhanced. [Methods] A 1.7kb PGK1 promoter and terminator were ligated and inserted into vector Yep-C to give the expression plasmid named Yep-CP. Then a 1. 7kb DNA fragment containing the open reading frame and terminator of mal62 gene was amplified from Saccharomyces cerevisiae BY-14 by PCR, and inserted into Yep-CP to generate recombinant plasmid Yep-CPM. To express mal62 gene properly in S. cerevisiae, the recombinant expression plasmids Yep-CPM with copper resistance gene as the selection marker for yeast transformation were introduced into S. cerevisiae BY-14. The resulting yeast transformant BYCPM was screened on YEPD with 4 mmol/L CuS04and identified by colony PCR. Target protein was detected by qRT-PCR, and the enzyme activities and the leavening ability of the recombinant strain BYCPM were determined to confirm whether functional expression was achieved. [ Results ] The maximum maltase activity of recombinant strain BYCPM was 15

  16. Epidemiologia da malária em Cabo Verde - Factores genéticos humanos e estrutura populacional do mosquito vector

    OpenAIRE

    Alves, Joana Baptista

    2010-01-01

    A malária, doença parasitária complexa que resulta da interacção entre parasita, hospedeiros humano e vector, constitui um dos principais problemas de saúde a nível mundial. À semelhança de outras doenças parasitárias e infecciosas a malária tem um papel importante na evolução, tendo já sido demonstrado o papel da variação genética humana na resistência à infecção. Após quase meio século de controlo, a malária persiste na ilha de Santiago onde, apesar da baixa endemicidade, os indivíduos a...

  17. Silêncio - crítica - aprendizado: uma análise teológica introdutória ao tema do mal

    Directory of Open Access Journals (Sweden)

    Claudio de Oliveira Ribeiro

    2011-12-01

    Full Text Available RESUMOO texto apresenta implicações para o tema do mal oriundas do encontro da teologia com o pensamento moderno, tanto o que se consolidou no final do século 19, fortemente marcado pelo racionalismo e pelo iluminismo, como o que resultou das críticas vindas das filosofias da existência já nas primeiras décadas do século 20. Trata também da relação entre o mal e o pecado e do mal e do sofrimento como fragilidades originais do ser humano. A referência interpretativa é a de evitar as visões de uma “teologia da retribuição”, meritória, capaz de em seu extremo gerar a ideia de um deus cruel. O mal é visto, sobretudo, por aquilo que prejudica ou fere a vida e a felicidade do humano e do mundo. Como decorrência da vocação prática da teologia, são indicadas posturas consideradas adequadas frente ao mal. Palavras-chave: Mal; pecado; teologia contemporânea; antropologia.ABSTRACTThe paper presents implications for the issue of evil arising from the encounter of theology with modern thought, which were consolidated both, in the late nineteenth century, strongly influenced by rationalism and the Enlightenment, and the first decades of the twentieth century, by the criticism of existentialist philosophy. It also addresses the relationship between evil and sin and evil and suffering as a unique human frailty. The interpretive reference is to avoid the visions of a “theology of retribution,” worthy, capable of generating at its extreme the idea of a cruel god. Evil is seen above all by what harms or injures life and happiness of the human and the world. As a result of the practical nature of theology, are indicated attitudes considered appropriate against the evil.Keywords: Evil; sin; contemporary theology; anthropology.RESUMENEl texto presenta implicaciones para el tema del mal provenientes del encuentro de la teología con el pensamiento moderno, tanto el que se consolidó hacia finales del siglo XIX, fuertemente marcado por

  18. Crystal Structure and Interaction with DNA of [Ni(phen)(mal)(H2O)2]·3H2O

    Institute of Scientific and Technical Information of China (English)

    GAO En-Jun; CHEN Mao-Sheng; YU Ying; SUN Ya-Guang

    2007-01-01

    A new complex [Ni(phen)(mal)(H2O)2]·3H2O (phen = 1,10-phenanthroline,mal2-= malonic acid) has been synthesized by the reaction of nickel nitrate,phen and malonic acid.EA,IR spectra and X-ray single-crystal diffraction were carried out to determine the composition and crystal structure of the title complex.Crystal data:monoclinic system,space group P2/c,a =8.937(3),b = 12.163(5),c = 9.725(3)(A),β = 119.36°,C15H19N2O9Ni,Mr= 430.03,Z = 2,F(000) =446,V = 921.3 (A)3,Dc = 1.550 g/cm3,μ = 1.104 mm-1,-10≤h≤ 10,-12≤k≤ 14,-11 ≤l≤7,R =0.0261 and wR = 0.0609 for 4376 (Rint = 0.0203) independent reflections and 1631 observed ones (I> 2σ(I)).Ni(Ⅱ) exhibits an octahedral coordination geometry,with hydrogen bonds and π-π interactions stabilizing the whole structure.UV spectrum of the complex interacting with protamine DNA indicates that the title compound interacts with DNA via insertion mode with bonding constant Kb of 1.11 × 104.

  19. Presencia de Anopheles (Nyssorhynchus benarrochi en áreas de selva con transmisión malárica

    Directory of Open Access Journals (Sweden)

    Roberto Fernández L

    2004-10-01

    Full Text Available Objetivos: Demostrar la presencia de An. (Nys. benarrochi en áreas de transmisión malárica, donde es frecuentemente identificado como An. evansae. Materiales y métodos: Se colectaron mosquitos en San José (Pucallpa, Muniches y Andoas (Alto Amazonas, localidades con transmisión de malaria. Con estos mosquitos se efectuaron crías biológicas en laboratorio con la finalidad de obtener material de estudio como son exuvias de larvas, pupas, adultos hembras y machos. Se efectuaron montajes de exuvias de larvas y pupas asociados con sus respectivos adultos, disecciones de las genitalias de machos y biometría de los adultos machos y hembras. Resultados: Además de las verificaciones efectuadas en el campo, basadas en el estudio de inmaduros y adultos, las crías biológicas efectuadas confirmaron la presencia de An. benarrochi en las localidades mencionadas. Asimismo, confirmaron también la existencia de gran variabilidad de los caracteres morfológicos externos, que pueden inducir al error en las identificaciones. Conclusiones: En las áreas maláricas estudiadas, la especie identificada como An. (Nys. evansae corresponde a An. (Nys. benarrochi, demostrado con nuestros estudios. Dada la variabilidad de caracteres que dificultan la identificación de las especies afines, es necesario realizar estudios completos con la finalidad de conocer la fauna local de anofelinos.

  20. Long-term follow-up of metil aminolevulinate (MAL)-PDT in difficult-to-treat cutaneous Bowen's disease.

    Science.gov (United States)

    Cavicchini, Stefano; Serini, Stefano Maria; Fiorani, Roberta; Girgenti, Valentina; Ghislanzoni, Massimo; Sala, Francesco

    2011-08-01

    Bowen's disease (BD) is a form of intraepidermal squamous cell carcinoma, which is clinically characterized by gradually enlarging, well-demarcated erythematous plaques with irregular borders and surface crusting or scaling, affecting primarily the elderly. BD often presents with lesions difficult to treat with standard therapy as surgery, cryosurgery, or 5-fluorouracil (5-FU) for the risk of significantly poor cosmetic outcome, failure rate, and adverse events, related mainly to the age of the patients. Topical PDT with methyl aminolevulinate (MAL) represents a valid and approved therapy for BD lesions in many cases, especially for lesions located at poor healing sites or for large patches of disease, due to its high efficacy coupled with good tolerability and tissue-sparing attitude. In this study, we sought to investigate the efficacy, safety, and cosmetic outcome of MAL-PDT in a series of patients with BD lesions which were challenging to treat for clinical, surgical, and patient-related reasons, such as size of the lesion, difficult surgical approach for anatomical sites, or age of patients and request of the best cosmetic result. We also performed a long-term follow-up to assess recurrence rates and eventual late-onset adverse events.

  1. Experience and BCC subtypes as determinants of MAL-PDT response: preliminary results of a national Brazilian project.

    Science.gov (United States)

    Ramirez, Dora P; Kurachi, Cristina; Inada, Natalia M; Moriyama, Lilian T; Salvio, Ana G; Vollet Filho, José D; Pires, Layla; Buzzá, Hilde H; de Andrade, Cintia Teles; Greco, Clovis; Bagnato, Vanderlei S

    2014-03-01

    Non-melanoma skin cancer is the most prevalent cancer type in Brazil and worldwide. Photodynamic therapy (PDT) is a noninvasive technique with excellent cosmetic outcome and good curative results, when used for the initial stages of skin cancer. A Brazilian program was established to determine the efficacy of methyl aminolevulinate (MAL)-PDT, using Brazilian device and drug. The equipment is a dual device that combines the photodiagnosis, based on widefield fluorescence, and the treatment at 630nm. A protocol was defined for the treatment of basal cell carcinoma with 20% MAL cream application. The program also involves the training of the medical teams at different Brazilian regions, and with distinct facilities and previous PDT education. In this report we present the partial results of 27 centers with 366 treated BCC lesions in 294 patients. A complete response (CR) was observed in 76.5% (280/366). The better response was observed for superficial BCC, with CR 160 lesions (80.4%), when compared with nodular or pigmented BCC. Experienced centers presented CR of 85.8% and 90.6% for superficial and nodular BCC respectively. A high influence of the previous doctor experience on the CR values was observed, especially due to a better tumor selection.

  2. In Vivo Non-Invasive Evaluation of Actinic Keratoses Response to Methyl-Aminolevulinate-Photodynamic Therapy (MAL-PDT) by Reflectance Confocal Microscopy

    OpenAIRE

    Marina Venturini; Arianna Zanca; Piergiacomo Calzavara-Pinton

    2014-01-01

    Photodynamic therapy (PDT) with methyl-aminolevulinate (MAL) is an approved non-invasive treatment option for actinic keratoses (AKs). In vivo reflectance confocal microscopy (RCM) is a non-invasive tool for real-time imaging of epidermis and superficial dermis in vivo that has been previously reported to facilitate the in vivo evaluation of skin lesions, including AKs. The aim of this study was to investigate the use of in vivo RCM in evaluating AKs response to MAL-PDT. For this reason a tot...

  3. La cromatografía de gases y la espectometría de masas: identificación de compuestos causantes de mal olor

    OpenAIRE

    Gutiérrez Bouzán, Mª Carmen; Droguet, Marta

    2002-01-01

    Se describe la cromatografía de gases y su acoplamiento con la espectrometría de masas, técnicas que constituyen una herramienta potente para separar, identificar y cuantificar los componentes volátiles y semivolátiles de mezclas complejas. Se aplican estas técnicas a la identificación de los compuestos que producen mal olor en un tejido. Para ello, se emplea también la extracción de espacio en cabeza. De los resultados del análisis GC-MS se desprende que la principal causa del mal olor e...

  4. Mal tiempo, tiempo maligno, tiempo de subversión ritual. La temposensitividad agrofestiva invernal

    Directory of Open Access Journals (Sweden)

    Del Campo Tejedor, Alberto

    2006-06-01

    ícolas y expresivo (rituales y fiestas; y, finalmente, un tiempo bipolar, que se experimenta desde antiguo en dos estaciones —invierno y verano—, base de una temposensitividad agrofestiva igualmente dicotómica, que es analizada a raíz de la siguiente hipótesis: durante los meses de buen tiempo, especialmente mayo y junio, los rituales de nuestro entorno funcionan con un sentido propiciatorio y de exaltación positiva, escenificando miméticamente la unión entre tierra, vegetación, animal y hombre a través de prototipos o arquetipos que recrean simbólicamente el orden natural de las cosas. Por el contrario, las fiestas y rituales invernales —desde Todos los Santos hasta el Carnaval, y muy especialmente los días en torno a la Navidad— tienen en común su carácter grotesco y de inversión del orden, que expresa en clave simbólica, con una lógica jocoseria y ambigua, el lado oscuro de la existencia, conjurando ritualmente los miedos al mal tiempo, al tiempo aciago y nefasto, al tiempo del frío, la noche, el hambre y la muerte.

  5. Manobras para o tratamento da vertigem posicional paroxística benigna: revisão sistemática da literatura Maneuvers for the treatment of benign positional paroxysmal vertigo: a systematic review

    Directory of Open Access Journals (Sweden)

    Lázaro Juliano Teixeira

    2006-02-01

    Full Text Available A Vertigem Posicional Paroxística Benigna (VPPB é uma das mais freqüentes patologias do sistema vestibular e é caracterizada por episódios de vertigens recorrentes desencadeados por movimentos da cabeça ou mudanças posturais. Há várias opções para o seu tratamento, porém as efetividades terapêuticas das mesmas permanecem controversas. OBJETIVO: Avaliar a efetividade terapêutica das manobras específicas disponíveis para o tratamento da VPPB. METODOLOGIA: Realizou-se uma busca eletrônica nas principais bases de dados, selecionando-se estudos clínicos randomizados envolvendo adultos com diagnóstico de VPPB confirmado com o teste de Dix-Hallpike e tratamento com manobras específicas (Epley ou Semont, por exemplo. Considerou-se como desfecho clínico a negativação do teste de Dix-Hallpike e a melhora das queixas subjetivas. Agruparam-se em metanálise os estudos com Escala de Jadad igual ou superior a três. RESULTADOS: Cinco estudos clínicos preencheram os critérios de inclusão, ou seja, ensaios randomizados de fase I comparando a manobra de Epley com placebos e controles. A metanálise mostra evidência dos efeitos benéficos da manobra de Epley para o tratamento do canal semicircular posterior (magnitude do efeito de 0,11 [IC 95% 0.05, 0.26] de melhora objetiva (Dix-Halpike após uma semana, 0.24 [IC 95% 0.13, 0.45] após um mês e 0.16 [IC 95% 0.08, 0.33] de melhora referida pelos pacientes após a primeira semana. CONCLUSÃO: Evidencia-se boa eficácia clínica da manobra de Epley para o tratamento da VPPB do canal semicircular posterior. Contrariamente, trabalhos com a manobra de Semont e as propostas de manejo dos demais canais semicirculares não obtiveram qualidade metodológica satisfatória, não sendo possível demonstrar a efetividade dos mesmos.Benign Paroxysmal Positional Vertigo (BPPV is one of the most frequent diseases of the vestibular system and it is characterized by episodes of recurrent vertigo

  6. Eletrodo de marca-passo mal posicionado no ventrículo esquerdo Electrodo de marcapasos mal posicionado en el ventrículo izquierdo Pacemaker electrode misplaced in the left ventricle

    Directory of Open Access Journals (Sweden)

    André Luiz Cerqueira de Almeida

    2010-09-01

    Full Text Available Relatamos caso de implantação anômala de eletrodo de marca-passo VVI no ventrículo esquerdo (VE, diagnosticada durante avaliação de rotina, dois anos pós-implante. Trata-se de mulher de 65 anos e soropositiva para doença de Chagas. O eletrocardiograma (ECG apresentava padrão de bloqueio do ramo direito. A radiografia de tórax em perfil mostrou trajeto com curvatura posterior do eletrodo. No ecocardiograma transtorácico, o diagnóstico final mostrou cateter que penetrava o átrio direito, atravessava o septo interatrial e descia pelo átrio esquerdo e orifício valvar mitral para se implantar na parede lateral do VE. Abordam-se os seguintes aspectos relacionados: possíveis trajetos de implantação, quadro clínico, radiológico, eletrocardiográfico, ecocardiográfico, complicações e opções terapêuticas.Relatamos caso de implantación anómala de electrodo de marcapasos VVI en el ventrículo izquierdo (VI, diagnosticada durante evaluación de rutina, dos años post implante. Se trata de mujer de 65 años y seropositiva para enfermedad de Chagas. El electrocardiograma (ECG presentaba estándar de bloqueo de rama derecha. La radiografía de tórax de perfil mostró trayecto con curvatura posterior del electrodo. En el ecocardiograma transtorácico, el diagnóstico final mostró catéter que penetraba el atrio derecho, atravesaba el septo interatrial y descendía por el atrio izquierdo y orificio valvar mitral para implantarse en la pared lateral del VI. Se abordan los siguientes aspectos relacionados: posibles trayectos de implantación, cuadro clínico, radiológico, electrocardiográfico, ecocardiográfico, complicaciones y opciones terapéuticas.This study reports the case of an anomalous implantation of VVI pacemaker electrode in the left ventricle (LV diagnosed during routine evaluation, two years after implantation. The patient is a 65-year-old woman with Chagas disease. Electrocardiogram (ECG revealed a pattern of right

  7. Hiperglicemia materna diária diagnosticada pelo perfil glicêmico: um problema de saúde pública materno e perinatal Maternal daily hyperglycemia diagnosed by glycemic profile: a maternal and perinatal public health problem

    Directory of Open Access Journals (Sweden)

    Marilza Vieira Cunha Rudge

    2005-11-01

    Full Text Available Este trabalho constitui uma síntese e revisão dos principais resultados das pesquisas, com o objetivo de validar o grupo IB de Rudge. As gestantes deste grupo têm rastreamento positivo e diagnóstico negativo para o diabete gestacional, ou seja, apresentam resposta normal ao teste oral de tolerância à glicose (TTG100g. Apesar disso, as alterações nas glicemias ao longo do dia, confirmadas no perfil glicêmico (PG caracterizam a hiperglicemia diária, fator responsável por risco materno e desfecho perinatal adverso. Estas gestantes são erroneamente incluídas na categoria de "pré-natal de baixo risco" e não estão sendo diagnosticadas e tratadas. Correspondem a 13,8% da população de gestantes rastreadas que, somados aos 7,0% das gestações complicadas por diabete, aumentam a ocorrência de distúrbios hiperglicêmicos na gestação para cerca de 20,0%. Tem índice de mortalidade perinatal de 41‰, semelhante ao de gestantes diabéticas e 10 vezes maior que o de não diabéticas; suas placentas apresentam alterações morfológicas e funcionais diferenciadas dos grupos de gestantes não diabéticas e diabéticas, indicativas de ajuste para manutenção da atividade funcional, facilitando a passagem de glicose para o feto e explicando a macrossomia fetal (53,8% das gestantes não tratadas. O risco materno para hipertensão, obesidade e hiperglicemia é elevado e parece reproduzir modelo da síndrome metabólica, favorecendo risco potencial para diabete no futuro; 10 anos após a gravidez-índice, o diabete clínico tipo 2 foi confirmado em 16,7% das mulheres do grupo IB. Os autores propõem o desenvolvimento de projetos multicêntricos, para identificar biomarcadores, de múltiplos enfoques, específicos das gestantes do grupo IB de Rudge e estabelecer protocolos para o diagnóstico dos distúrbios hiperglicêmicos da gestação, padronizando a associação TTG100g + PG, conduta que poderá causar impacto na morbimortalidade

  8. Mal-β-CD对黑胡椒精油的包合作用研究%Research on inclusion properties of maltosyl-β-cyclodextrin by forming complexes essential oil from piper nigrum

    Institute of Scientific and Technical Information of China (English)

    王冠群; 曲静然; 丁烽; 崔波; 檀琮萍

    2012-01-01

    Studied the inclusion interaction between Mal-β-CD and β-caryophyllene. Mole ratios of Mal-β-CD and β-caryophyllene, inclusion temperature, inclusion time as variables, inclusion rate of as index, technology parameters of inclusion reaction were optimized by orthogonal experiments. The inclusion compound was identified by infrared(IR) spectrometry, thermogravimetric (TG). The result showed that the optimal conditions for the inclusion compound were as follows: The result showed that the optimal conditions for the inclusion compound were as follows: inclusion temperature 70 "C , inclusion time 90 min, mole ratios of Mal-β-CD and βcaryophyllene 1 : 1. The inclusion of Mal-β-CD with oil from piper nigrum showed high stability, good solublity, the critical humidity of the inclusion was about 67%.%研究Mal-β-CD对黑胡椒精油的包合作用.以包埋率为指标,以包合温度、包合时间和Mal-β-CD和β-石竹烯的摩尔比为变量,通过正交试验确定最佳包合反应工艺参数是包合温度70℃,包合时间90 min,Mal-β-CD和β-石竹烯的摩尔比为1∶1;通过红外扫描和热重分析,确认Mal-β-CD-β-石竹烯包合物的形成,热重分析表明β-石竹烯经Mal-β-CD包埋后,耐热性显著提高;Mal-β-CD包合黑胡椒精油的包合产物稳定性较好,水溶性好,包合物的临界湿度为67%.

  9. Decrease of the IgE-binding by Mal d 1, the major apple allergen, by means of polyphenol oxidase and peroxidase treatments

    NARCIS (Netherlands)

    Garcia-Borrego, A.; Wichers, J.H.; Wichers, H.J.

    2007-01-01

    Mal d 1, the major apple allergen, is heat labile and easily oxidized. Oxidative reactions catalyzed by polyphenol oxidase (PPO) and/or peroxidase (POD), present in apple, may be involved in decreasing its allergenicity. PPO and POD convert phenolic compounds into o-quinones. In this study the effec

  10. Development of hypo-allergenic apples: silencing of the major allergen Mal d 1 gene in 'Elstar' apple and the effect of grafting

    NARCIS (Netherlands)

    Krath, B.N.; Eriksen, F.D.; Pedersen, B.H.; Gilissen, L.J.W.J.; Weg, van de W.E.; Dragsted, L.O.

    2009-01-01

    Many people who are allergic to birch pollen are also allergic to apple fruit, due to cross- allergenicity. Since apples are the most extensively consumed fruit in Europe, it is highly relevant to develop a hypo-allergenic apple. Apples with significantly reduced levels of the allergen, Mal d 1, may

  11. In Vivo Non-Invasive Evaluation of Actinic Keratoses Response to Methyl-Aminolevulinate-Photodynamic Therapy (MAL-PDT by Reflectance Confocal Microscopy

    Directory of Open Access Journals (Sweden)

    Marina Venturini

    2014-03-01

    Full Text Available Photodynamic therapy (PDT with methyl-aminolevulinate (MAL is an approved non-invasive treatment option for actinic keratoses (AKs. In vivo reflectance confocal microscopy (RCM is a non-invasive tool for real-time imaging of epidermis and superficial dermis in vivo that has been previously reported to facilitate the in vivo evaluation of skin lesions, including AKs. The aim of this study was to investigate the use of in vivo RCM in evaluating AKs response to MAL-PDT. For this reason a total of 10 biopsy-proven AKs were treated by MAL-PDT, according to standard PDT protocol for AKs. RCM investigation was performed before and after PDT and RCM-guided punch biopsies was taken at 3 months in all patients for histopathologic examination. At 3 months follow-up, complete clinical response was observed by clinical examination in 9 out of 10 lesions and a partial clinical response in 1 lesion. In vivo RCM detected two residual AKs in subclinical form, missed by clinical examination. Histological analysis confirmed these results. In vivo RCM may be a new alternative tool for the non-invasive diagnosis of AKs and evaluation of AKs response to non-invasive treatments, as MAL-PDT, improving the ability of dermatologists to diagnose AKs even in subclinical stage.

  12. Sobre o Mal-estar Hoje: Do Cérebro à Pulsão de Morte

    Directory of Open Access Journals (Sweden)

    Barbara Paraiso Garcia Duarte da Rosa

    2013-01-01

    Full Text Available Hace unos años las pruebas formuladas por las neurociencias y la proliferación de categorías psicopatológicas ha colaborado para la legitimación y la multiplicación de los discursos llenos de promesas de curación de sufrimiento psíquico. En este contexto — donde la psicopatología está dirigida de un concepto predominante biológico y la proliferación de categorías diagnósticos Si acompañada por el predominio de un enfoque sindrómico de la enfermedad mental — el énfasis en la terapia biológica opera como la promesa de eliminar el malestar de la vida. Este es un proceso de naturalización de la angustia en que multiplicación de categorías de diagnósticos es proporcional a la diversidad de sufrimiento psíquico que puede ser tratado. Presentamos algunos conceptos forjadas por Freud, como la angustia, la impotencia y la pulsión de muerte, como indicadores de la posibilidad de intervenir en el sufrimiento a través de varias perspectivas de aquellos que prometen la exclusión del mal en la vida psíquico. Si malo es signo de desorden promovido por pulsión que no pudo inscribirse en el aparato psíquico, entonces psicoanálisis incluyen mal en el corazón de su propia vida psíquica. El último solamente si es y gracias a la posibilidad de crear nuevos significados, nuevas formas de satisfacción posible para el impulso vital, insistente por excelencia.

  13. Mal de Chagas y factores geográficos. Propuesta de zonificación del riesgo epidemiológico, municipio Araure, Estado Portuguesa. Venezuela

    Directory of Open Access Journals (Sweden)

    Karen Rojas

    2015-01-01

    Full Text Available Son numerosas las enfermedades transmitidas por vectores que afectan la salud y que han sido objeto de estudio, en este sentido, el mal de Chagas es la cuarta forma más importante de enfermedad tropical, superada solamente por la malaria, la tuberculosis y la esquistosomiasis. Según la OPS (2014, la enfermedad está asociada a factores ambientales y sociales que expone a millones de personas a la infección. El objetivo de este trabajo es proponer una zonificación del riesgo epidemiológico del mal de Chagas en el municipio Araure, estado Portuguesa, Venezuela, a partir del uso de la matriz multicriterio. Se realizó una caracterización de los factores físico naturales (altitud, temperatura, precipitación, humedad relativa y socioeconómicos (estructura de la población, actividades económicas, tipo de viviendas, pobreza, de igual manera se hizo una caracterización del mal de Chagas. Los resultados establecieron que existe un área de riesgo epidemiológico al contagio del mal de Chagas en el municipio, específicamente en las áreas rurales ubicadas en el extremo oeste del área de estudio donde predominan las viviendas tipo rancho. Se concluye que el área es vulnerable al mal de Chagas y deben fortalecerse las medidas de prevención y control. Una de estas medidas seria realizar campañas de difusión sobre la prevención y control de la enfermedad, a través de todos los medios de comunicación y capacitación y educación comunitaria que conlleven a ampliar las actividades de vigilancia.

  14. Light fractionation increases the efficacy of ALA-PDT but not of MAL-PDT: What is the role of (vascular) endothelial cells?

    Science.gov (United States)

    de Bruijn, H. S.; de Vijlder, H. C.; de Haas, E. R. M.; van der Ploeg-van den Heuvel, A.; Kruijt, B.; Poel-Dirks, D.; Sterenborg, H. J. C. M.; ten Hagen, T. L. M.; Robinson, D. J.

    2009-06-01

    Photodynamic therapy (PDT) using protoporpyrin IX (PpIX) precursors like 5-aminolevulinic acid (ALA) or methyl-aminolevulinate (MAL) has shown to be effective in the treatment of various skin diseases. Using ALA we have shown in numerous studies a significantly improved efficacy by applying light fractionation with a long dark interval. In contrast, in the hairless mouse model, the PDT efficacy using MAL is unaffected by adopting this approach. More acute edema is found after ALA-PDT suggesting a difference in response of endothelial cells to PDT. To investigate the role of endothelial cells, cryo-sections of hairless mouse skin after 4 hours of topical MAL or ALA application were stained with a fluorescent endothelial cell marker (CD31). Co-localization of this marker with the PpIX fluorescence was performed using the spectral imaging function of the confocal microscope. We have also used intra-vital confocal microscopy to image the PpIX fluorescence distribution in correlation with the vasculature of live mouse skin. Our results show PpIX fluorescence at depth in cryo-sections of mouse skin after 4 hours of topical application. Co-localization has shown to be difficult due to the changes in tissue organization caused by the staining procedure. As expected we found high PpIX fluorescence levels in the epidermis after both MAL and ALA application using intra-vital microscopy. After ALA application more PpIX fluorescence was found deep in the dermal layer of the skin than after MAL. Furthermore we detected localized fluorescence in unidentified structures that could not be correlated to blood vessels or nerves.

  15. Estudo exploratório da utilização de saw palmetto no tratamento da hiperplasia benigna da próstata por urologistas de Porto Alegre Investigation study concerning the saw palmetto use for the benign prostatic hyperplasia treatment by urologists in Porto Alegre

    Directory of Open Access Journals (Sweden)

    Gabriela Ferreira

    2008-06-01

    Full Text Available O objetivo deste trabalho foi avaliar a utilização de fitoterápicos a base de saw palmetto na terapia sintomática da hiperplasia benigna da próstata (HBP por médicos urologistas da cidade de Porto Alegre. Consistiu em um estudo transversal, exploratório, por meio de entrevista semi-estruturada aplicada a urologistas de Porto Alegre. A amostra foi obtida utilizando catálogo do plano de saúde UNIMED- Porto Alegre. A randomização foi realizada através de sistemática aleatória, sendo sorteados trinta e cinco médicos, dos quais 21 foram selecionados para realização da pesquisa através de questionário. Todos os urologistas entrevistados avaliam e tratam pacientes com hiperplasia benigna da próstata. O saw palmetto não foi citado como terapia medicamentosa de 1ª ou 2ª escolhas no tratamento da HBP. O grupo farmacológico mais freqüentemente utilizado para o tratamento da HBP foi ∝-bloqueadores. Mais da metade dos médicos entrevistados relata ter conhecimento sobre a utilização do saw palmetto, principalmente através de artigos científicos. Os resultados indicam que o saw palmetto não é prescrito pelos urologistas em Porto Alegre, todavia a maior parte destes profissionais tem conhecimento sobre sua utilização.The aim of this work was to assess the prescription of saw palmetto phytomedicines for improving symptoms of benign prostatic hyperplasia (BPH by urologists in Porto Alegre (Brazil. The study was transversal and exploratory consisting of a semi-structured interview with urologists. The sample was obtained from the UNIMED Catalog - Porto Alegre (Brazil. The randomization was made by chance, being selected thirty-five physicians. The first twenty-one who accepted to participate were interviewed. All the interviewed urologists treat patients with benign prostatic hyperplasia. The saw palmetto was not mentioned as the first or second choice for treating BPH. The α-blockers were the most mentioned pharmacological

  16. O puru-puru da Amazônia (Pinta, Carate, Mal del Pinto etc

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    F. Nery Guimarães

    1948-03-01

    Full Text Available 1 "Purú-purú" é uma palavra indígena que quer dizer "pintado" ou "manchado", peculiar à Amazonia Brasileira. Com êsse nome é designada uma dermatose referida entre os selvicolas desde 1774, por Ribeiro Sampaio. Certas tribus, com alta incidência da moléstia passaram a ser cahamadas também "Purú-purús", o mesmo acontecendo com o rio onde habitavam - Rio Purús. 2 A doença existe na bacia do Rio Solimões e seus principais afluentes: Javari, Juruá, Purús, Içá, Japurá, e Negro. Por esses rios, o fóco da dermatose se continua nos países limitrofes com o Brasil: Guianas, Venezuela, Colombia, Perú (Equador e Bolivia. 3 Desde 1890 essa dermatose foi relacionada à pinta (carate ou mal del pinto por P. S. de Magalhães, idéa essa depois defendida por Juliano Moreira, Carlos Chagas, Roquete Pinto, Wappeus, O. da Fonseca Filho, Da Matta, Brumpt e outros, baseados na semelhança clínica e na terapêutica. Recentemente (1945, essa provavel identidade das duas dermatoses, recebeu fundamento sorológico de Biocca (que verificou a positividade das reações de Kline e Kahn em doentes de purú-purú, e, pelo presente trabalho, recebe base clínico-epidemio-anatomo-patológica. 4 Sob o ponto de vista clínico, as lesões cutaneas discromicas da moléstia, são de 3 órdens: a lesões papulo-eritemato-escamosas, isoladas ou não, arredondadas, pruriginosas e de bordos nitidos; b lesões maculo-escamosas, maiores mais pálidas, ás vezes já mostrando alterações pigmentares na parte central; c máculas discromod´rmicas, lisas ou ligeiramente escamosas, com maior ou menor alteração pigmentar, as quais assumem diferentes aspéctos, consequentes à hipo - ou hiperpigmentação, variaveis também com a côr do paciente. As colorações predominantes nas manchas, são o branco, o preto e o vermelho, com tonalidades eminentemente variaveis. Embora raramente, nessas extensas dermodiscromias, observa-se superposição de lesões papulo

  17. Crystallization, data collection and data processing of maltose-binding protein (MalE) from the phytopathogen Xanthomonas axonopodis pv. citri

    International Nuclear Information System (INIS)

    The Xanthomonas axonopodis pv. citri maltose-binding protein MalE has been crystallized at 293 K using the hanging-drop vapour-diffusion method. Maltose-binding protein is the periplasmic component of the ABC transporter responsible for the uptake of maltose/maltodextrins. The Xanthomonas axonopodis pv. citri maltose-binding protein MalE has been crystallized at 293 K using the hanging-drop vapour-diffusion method. The crystal belonged to the primitive hexagonal space group P6122, with unit-cell parameters a = 123.59, b = 123.59, c = 304.20 Å, and contained two molecules in the asymetric unit. It diffracted to 2.24 Å resolution

  18. Efeito de ação educativa participativa no conhecimento de professores do ensino básico sobre malária

    Directory of Open Access Journals (Sweden)

    Martha Cecilia Suárez-Mutis

    2011-10-01

    Full Text Available OBJETIVO: Descrever uma estratégia educativa participativa de construção de conhecimentos relacionados à malária entre professores em um município altamente endêmico. MÉTODOS: Foi feito um estudo observacional. Um curso de 40 horas foi realizado sob enfoque multidisciplinar e problematizador para 46 professores, prioritariamente da área rural, no município de Barcelos, AM, em 2008. O processo educativo participativo incluiu oficinas e aulas práticas. Para investigar os conhecimentos, aplicou-se um questionário previamente validado, antes e após o curso, avaliado por abordagens quantitativa e qualitativa usando a análise temática para respostas abertas. RESULTADOS: Previamente ao curso, os professores tinham pouca informação sobre os mecanismos de transmissão, meios de prevenção e a associação da malária aos seus vetores, bem como conceitos restritos sobre saúde. Após o curso, não somente aumentou o conhecimento dos professores sobre a malária como também emergiram reflexões sobre o papel do professor na sociedade. CONCLUSÕES: O efeito da ação educativa na construção de um saber contextualizado sobre malária e saúde indica o potencial da estratégia desenvolvida. Processos de educação permanente são necessários à sustentabilidade dos novos saberes e práticas, orientados pela promoção da saúde.

  19. The utilization of a non-invasive fluorescence imaging system to follow clinical dermatological MAL-PDT

    Science.gov (United States)

    Tyrrell, Jessica; Campbell, Sandra; Curnow, Alison

    2009-06-01

    This study employed a commercially available, non-invasive, fluorescence imaging system (Dyaderm, Biocam, Germany), to measure protoporphyrin IX (PpIX) concentration at several different stages during clinical dermatological methyl aminolevulinate photodynamic therapy (MAL-PDT). We validated the system prior to use to ensure that the PpIX changes witnessed were accurate and not due to environmental or user induced artifacts. The system was then employed to acquire color (morphological) and fluorescent (physiological) images simultaneously during dermatological PDT. Clinical data was collected from a range of licensed dermatological conditions (actinic keratosis, Bowen's disease and superficial basal cell carcinoma) during initial and subsequent PDT treatment cycles. The initial clinical data indicated that each type of licensed lesion considered responded in a similar manner following the application of Metvix (Galderma, U.K.) and the subsequent light irradiation (Aktilite, Galderma, U.K.). Images acquired three hours after Metvix application showed a significant increase in PpIX concentration within the lesion (P < 0.05), whilst PpIX levels in the surrounding normal tissue remained unaltered. After irradiation, the PpIX concentration was significantly decreased and returned to a level similar to the initial concentration originally observed. Lesions that received subsequent treatment cycles accumulated significantly less PpIX (P < 0.05) prior to irradiation.

  20. Malária no Brasil: panorama epidemiológico na última década

    Directory of Open Access Journals (Sweden)

    Barata Rita de Cássia B.

    1995-01-01

    Full Text Available Este artigo apresenta, de maneira resumida, as principais alterações que marcaram a ocorrência de malária, no Brasil, nesta última década. Chama-se a atenção para o processo de focalização da doença, com a concentração da transmissão em áreas, relativamente restritas, da região amazônica. A mudança na situação epidemiológica acarreta a revisãoconceitual, levando ao abandono da concepção de "doença de massa" e à elaboração da teoria focal. Do mesmo modo, as ações de controle sofrem os impactos das transformações ocorridas e as tentativas de erradicação são abandonadas e substituídas por medidas de controle diversificadas e adaptadas a cada localidade. As novas propostas, oriundas da Conferência Ministerial de Amsterdam, são apresentadas e comentadas.

  1. Návrh malého proudového motoru do 1kN tahu

    OpenAIRE

    Gongol, Jakub

    2013-01-01

    Tato práce je zaměřena na téma malých proudových motorů. Práce je rozdělena na rešeršní a výpočtovou část. V rešeršní části se zabývá jak různými konfiguracemi proudových motorů, tak i oblastmi jejich použití. Hlavní část práce je výpočtová, kde bude navržen kompresor, turbína a výstupní tryska v takové konfiguraci, ve které bude motor při návrhovém režimu dávat tah 1kN. Dále bude vypočtena charakteristika motoru v mimonávrhových režimech, která dá představu o tom jak se motor bude chovat za ...

  2. Instrumentação anterior da coluna em espondilite tuberculosa mal de pott: Relato de caso

    Directory of Open Access Journals (Sweden)

    Farage Luciano

    2002-01-01

    Full Text Available Relatamos caso de tratamento cirúrgico com instrumentação anterior em espondilite tuberculosa (mal de Pott, em mulher de 71 anos, que se encontrava em tratamento para tuberculose na forma pulmonar e evoluiu com dor lombar, dificuldade progressiva para deambular, cifose e disfunção vesical. A ressonância magnética revelou lesão nos corpos vertebrais de T12 e L1 com abcesso paravertebral. A paciente foi tratada cirurgicamente por acesso tóraco-abdominal lateral. Os corpos vertebrais foram ressecados, foi instalado uma gaiola vertical (mesh cage e a coluna foi estabilizada com placa lateral (Z plate e parafusos fixados em T11 e L2. Essa técnica permite boa artrodese dos corpos vertebrais remanescentes e boa estabilidade da coluna, sem comprometer a eficácia dos tuberculostáticos. A paciente foi avaliada um ano após a operação e não apresentava déficit motor, dor residual e a cifose foi desfeita.

  3. Surto de malária por Haemoproteus columbae em pombos An outbreak of malaria by Haemoproteus columbae in pigeons

    Directory of Open Access Journals (Sweden)

    J.S. Resende

    2001-06-01

    Full Text Available Relata-se um surto de malária por Haemoproteus columbae em pombos-correio (Columba livia, caracterizado por um quadro agudo com mortalidade de 3% ao dia em aves de aspecto saudável ou crônico com prostração e fraqueza. O exame clínico das aves doentes evidenciou sinusite e conjuntivite e à necropsia traqueíte hemorrágica, aerossaculite, esplenomegalia, nefromegalia e hepatomegalia com hemorragias. O díptero hematófago da família Hippoboscidae Pseudolynchia canariensis foi encontrado inserido entre as penas dos indivíduos. Esfregaços de sangue periférico e cardíaco e impressões de baço e fígado corados por Giemsa permitiram a visualização de inclusões intraeritrocitárias características de Haemoproteus columbae

  4. An ecosystem approach to malaria control in an urban setting Uma abordagem ecossistêmica ao controle da malária em contexto urbano

    Directory of Open Access Journals (Sweden)

    Gabriel Carrasquilla

    2001-01-01

    Full Text Available We conducted a research project aimed at strengthening local government and the community for a sustainable malaria control strategy. The project began with a baseline diagnosis of malaria prevalence, a KAP survey, entomology, and health services delivery, after which an epidemiological study was performed to identify risk factors associated with malaria, thereafter used to plan intervention measures. A program evaluation was conducted five years later. By using an ecosystem approach to reanalyze data, this paper discusses how malaria arises from a complex interaction of cultural, economic, ecological, social, and individual factors. Intervention measures require an intersectorial and transdisciplinary approach that does not exist at the moment. Health sector leadership is limited, and there is no true community participation. Implications for research, including the use of qualitative and quantitative methods, study design, and complexity of data analysis are discussed. Finally, implications for malaria control are discussed, stressing the differences between the ecosystem and integrated disease control approaches.Os autores implementaram um projeto de pesquisa voltado ao fortalecimento do governo local e da comunidade com vistas à estratégia sustentável de controle da malária. O projeto iniciou com diagnóstico prévio, incluindo prevalência da malária, entomologia, KAP (conhecimentos, atitudes e práticas e oferta de serviços de saúde; a seguir, realizou-se inquérito epidemiológico para identificar fatores de risco associados à malária e a escolha de medidas de intervenção adequadas. O programa foi avaliado após cinco anos. Ao adotar a abordagem ecossistêmica para re-analisar os dados, o artigo discute como a malária surge a partir da interação complexa entre fatores culturais, econômicos, ecológicos, sociais e individuais. Medidas de intervenção exigem abordagem intersetorial e transdisciplinar ainda não existente. A

  5. La inclusión social por la vía del cuerpo en mujeres diagnosticadas con anorexia bulimia en la ciudad de Medellín, Colombia = Social inclusion through the body in women with anorexia-bulimia in Medellín, Colombia

    Directory of Open Access Journals (Sweden)

    Marín Cortés, Andrés Felipe

    2010-12-01

    Full Text Available Este informe presenta los hallazgos de la investigación "Narrativas identitarias sobre la vivencia corporal en mujeres diagnosticadas con trastorno de la alimentación" efectuada en Medellín.Objetivo: reconocer cómo el significado atribuido a la vivencia corporal devela la construcción de la identidad en mujeres con trastornos de la alimentación.Metodología: enfoque cualitativo, con diseño de casos múltiples analizados mediante los procedimientos del método fenomenológico-hermenéutico. Se hicieron entrevistas en profundidad y grupos focales. El estudio se ajustó a los principios éticos para la investigación en que participan seres humanos, incluyendo el consentimiento informado de cada una de las participantes.Resultados: 1 la evaluación que estas mujeres hacen de sí mismas está cruzada por la mirada de los otros; 2 existen contextos sociales de aparición que estimulan la anorexia-bulimia; 3 se hallaron tres formas de configuración de la anorexia-bulimia: estético-erótica, estéticoatlética y estético-afectiva; 4 la recuperación no consiste solamente en comer, sino también en permitir que el cuerpo se historice, es decir, que muestre en él las marcas del paso del tiempo.

  6. «Gente de mal vivir»: families and incorrigible sons in new Spain, 1721-1729

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    Cáceres Menéndez, Beatriz

    2006-08-01

    Full Text Available Forced transportation to the Philippine and Mariana Islands, a form of social exile and the equivalent of deportation, was used in New Spain to punish criminals and people judged to be undesirable. Those who were sent across the Pacific were always male and usually American-born Spaniards. Both the viceregal government and parents thought forced transportation to be an appropriate way to rid Mexico not only of criminals but also of men «of evil living» - people whose lives were dedicated to gambling, public drunkenness, idleness, and immorality. Parents, brothers, and even wives therefore used forced transportation to eliminate unwanted family members whose behavior threatened to tarnish family honor.

    En la Nueva España el traslado forzoso de individuos a las Islas Filipinas y Marianas fue una forma de exilio equivalente a la deportación para castigar a los criminales y a la gente considerada indeseable. Los condenados fueron siempre hombres y usualmente españoles nacidos en América. Tanto el gobierno virreinal como los padres de familia pensaron en el traslado forzoso como un medio apropiado para limpiar el Reino no sólo de criminales sino también de «gente de mal vivir», es decir, aquellos dedicados al juego, la embriaguez pública, la ociosidad y la inmoralidad. Padres, hermanos y aún esposas utilizaron el traslado obligado como un medio para eliminar a los familiares cuyos comportamientos amenazaban manchar el honor de la familia.

  7. Associação da sulfametoxazol ao trimethoprim no tratamento da malária por Plasmodium falciparum

    Directory of Open Access Journals (Sweden)

    Joaquim Caetano de Almeida Netto

    1972-02-01

    Full Text Available A associação da suljametoxazol (SMZ ao Trimelhoprim (TMP foi ensaiada em 40 portadores de malária pelo Plasmodium falciparum, em duas etapas. Na primeira, foram observados 20 pacientes resistentes às 4-aminoquinoleinas. oligossintomáticos e com densidade parasitária baixa. A administração de 800 mg de SMZ + 160 mg de TMP a dez pacientes, em dose única, bem como, diariamente, durante 2 dias, a 10 outros, se mostrou capaz de promover o desaparecimento dos trofozitos do sangue periférico em todos os 20 casos. Seis dentre 13 pacientes deste grupo apresentaram recrudescência da parasitemia assexuada durante o período de controle, de 30 dias. Não foram observadas manifestações de intolerância. Na segunda etapa foram observados mais 20 pacientes também, em sua maioria, resistentes às 4-aminoquinoleinas, incluindo agora casos com quadro clínico severo. A administração de 1.600 mg SMZ + 320 mg de TMP, diariamente, durante 4 dias. promoveu a negativação de parasitemia assexuada em todos os pacientes dentro de um período de 82 a 96 horas. Deste grupo, 2 dentre os 20 pacientes apresentaram recrudescência clinica e parasitária no período de controle. Apenas 1 teve discreta anemia megaloblastica após o tratamento, que desapareceu espontâneamente.

  8. Sequential motor task (Luria's Fist-Edge-Palm Test in children with benign focal epilepsy of childhood with centrotemporal spikes Tarefa motora sequencial (Teste de Lúria punho-lado-palma em crianças com epilepsia focal benigna da infância com descarga centrotemporal

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    Carmen Silvia Molleis Galego Miziara

    2013-06-01

    Full Text Available This study evaluated the sequential motor manual actions in children with benign focal epilepsy of childhood with centrotemporal spikes (BECTS and compares the results with matched control group, through the application of Luria's fist-edge-palm test. The children with BECTS underwent interictal single photon emission computed tomography (SPECT and School Performance Test (SPT. Significant difference occurred between the study and control groups for manual motor action through three equal and three different movements. Children with lower school performance had higher error rate in the imitation of hand gestures. Another factor significantly associated with the failure was the abnormality in SPECT. Children with BECTS showed abnormalities in the test that evaluated manual motor programming/planning. This study may suggest that the functional changes related to epileptiform activity in rolandic region interfere with the executive function in children with BECTS.Esse estudo avaliou ações motoras manuais sequenciais em crianças com epilepsia focal benigna da infância com descarga centrotemporal (EBICT e comparou os resultados com o grupo controle pareado, através do teste de Lúria (punho-lado-palma. As crianças com EBICT realizaram single photon emission computed tomography (SPECT interictal e Teste de Desempenho Escolar (TDE. Foram encontradas diferenças significativas entre os dois grupos nas atividades motoras de três movimentos iguais e três movimentos diferentes. As crianças com piores resultados no TDE e com SPECT alterado apresentaram mais erros no teste de imitação manual. Crianças com epilepsia fracassaram nos testes de avaliação motora que envolvem programação/planejamento. Esse estudo sugere que mudanças funcionais relacionadas à atividade epileptiforme na região rolândica interfere com as funções executivas de crianças com EBICT.

  9. MosquitoMap and the Mal-area calculator: new web tools to relate mosquito species distribution with vector borne disease

    Directory of Open Access Journals (Sweden)

    Christensen Jamie

    2010-02-01

    Full Text Available Abstract Background Mosquitoes are important vectors of diseases but, in spite of various mosquito faunistic surveys globally, there is a need for a spatial online database of mosquito collection data and distribution summaries. Such a resource could provide entomologists with the results of previous mosquito surveys, and vector disease control workers, preventative medicine practitioners, and health planners with information relating mosquito distribution to vector-borne disease risk. Results A web application called MosquitoMap was constructed comprising mosquito collection point data stored in an ArcGIS 9.3 Server/SQL geodatabase that includes administrative area and vector species x country lookup tables. In addition to the layer containing mosquito collection points, other map layers were made available including environmental, and vector and pathogen/disease distribution layers. An application within MosquitoMap called the Mal-area calculator (MAC was constructed to quantify the area of overlap, for any area of interest, of vector, human, and disease distribution models. Data standards for mosquito records were developed for MosquitoMap. Conclusion MosquitoMap is a public domain web resource that maps and compares georeferenced mosquito collection points to other spatial information, in a geographical information system setting. The MAC quantifies the Mal-area, i.e. the area where it is theoretically possible for vector-borne disease transmission to occur, thus providing a useful decision tool where other disease information is limited. The Mal-area approach emphasizes the independent but cumulative contribution to disease risk of the vector species predicted present. MosquitoMap adds value to, and makes accessible, the results of past collecting efforts, as well as providing a template for other arthropod spatial databases.

  10. Sobre los saberes culturales y el fenómeno "sentirse bien-sentirse mal" On cultural knowledge and the phenomenon "feel good-fell bad"

    Directory of Open Access Journals (Sweden)

    Virtudes Rodero Sánchez

    2010-09-01

    Full Text Available El objetivo del presente estudio es identificar los saberes culturales inmersos en el fenómeno "sentirse-bien, sentirse mal", en diferentes situaciones de cuidado. Se elaboró un estudio cualitativo con un enfoque fenomenológico interpretativo, mediante el análisis de 18 narrativas a partir de entrevistas en profundidad realizadas por alumnas del Máster en Ciencias de la Enfermería en diferentes contextos de cuidados. Las categorías identificadas fueron: (1 Cronicidad y concepto de sentirse bien-sentirse mal. En la cronicidad este concepto está íntimamente relacionado con la recuperación de las actividades de la vida diaria y es componente importante en la percepción individual del concepto "calidad de vida". (2 Momentos agudos de enfermedad y concepto de sentirse bien-sentirse mal. En el análisis de los relatos del paciente aparecieron aspectos esenciales del fenómeno "sentirse bien-sentirse mal" para aumentar la comprensión de aspectos universales de algunos de sus componentes. Destacar que el fenómeno está íntimamente relacionado con la recuperación de las actividades de la vida diaria, y es un mediador importante en la percepción individual del concepto "calidad de vida". El interés de cara al cuidado es distinguir sus componentes universales, contextualizarlos en la práctica, dentro de las singularidades que presenta cada persona, de modo que nos permita su potenciación. El resultado es un cambio en la experiencia sentida.The object of the present study is to identify cultural knowledges immersed in the feeling-well, feeling-bad phenomenon in different care settings. A qualitative study was undertaken using a phenomenological interpretation approach through a meta-analysis of 18 narratives of profound interviews undertaken by Nursing Science Master Degree Students in different care situations. The categories established were: (1 Chronicity and the concept of feeling well-feeling bad. In this category, this concept is

  11. A banalização do mal: sobre Auschwitz, a religião do cotidiano e a teoria social

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    Detlev Claussen

    2013-07-01

    Full Text Available Neste artigo, traduzido para o português por Rodrigo Duarte, Detlev Claussen discute a banalização do mal a partir da relação da indústria cultural com Auschwitz. O autor sugere que a substituição dessa palavra pelo termo mais geral “holocausto” é uma das estratégias empregadas pelos meios de massa para trivializar a comunicabilidade do que se passou nesse campo de concentração – uma experiência que permanece essencialmente incomunicável.

  12. Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection

    OpenAIRE

    Valkov, Eugene; Stamp, Anna; DiMaio, Frank; Baker, David; Verstak, Brett; Roversi, Pietro; Kellie, Stuart; Sweet, Matthew J.; Mansell, Ashley; Gay, Nicholas J.; Jennifer L Martin; Kobe, Bostjan

    2011-01-01

    Initiation of the innate immune response requires agonist recognition by pathogen-recognition receptors such as the Toll-like receptors (TLRs). Toll/interleukin-1 receptor (TIR) domain-containing adaptors are critical in orchestrating the signal transduction pathways after TLR and interleukin-1 receptor activation. Myeloid differentiation primary response gene 88 (MyD88) adaptor-like (MAL)/TIR domain-containing adaptor protein (TIRAP) is involved in bridging MyD88 to TLR2 and TLR4 in response...

  13. From “the symbolic wood” to the mythic interpretation of evil. A reading of Vision de los hijos del mal by Miguel Angel Bustos.

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    Estrella Isabel Koira

    2015-04-01

    Full Text Available An approach to Miguel Angel Bustos's poetry requires a methodological reexamination that does not sever its semantic flow. A poetry that seeks deep and heightened sense and that conceives its word as verb of divine origin cannot be analyzed without the understanding of the prefigured transcendence of its genesis. Attending to this predicament, we observe that the ricoeurian hermeneutics provides us with a consonant tool which forges a bond between word and existence. In Vision de los hijos del mal, Ricoeur's concepts of symbol and myth allow an access to the close relation among the experience of evil, language and sense.

  14. Estudo comparativo não randomizado do midazolam versus thiopental em crianças com estado de mal epiléptico refratário

    OpenAIRE

    LÖHR JUNIOR ALFREDO; WERNECK LINEU CESAR

    2000-01-01

    Avaliamos o uso do midazolam em relação ao thiopental em crianças com estado de mal epiléptico refratário(EMER). Foram estudadas 50 crianças com EMER, internadas em UTI-pediátrica, composto pelos: Grupo Midazolam(A) (n=24) prospectivo, e o Grupo Thiopental(B) (n=26) histórico. Benzodiazepina e difenil-hidantoina e outros anticonvulsivantes foram previamente utilizadas nos dois grupos. Não havendo o controle das convulsões, no Grupo A os pacientes receberam uma dose de 200 mig/kg midazolam int...

  15. Linkage map positions and allelic diversity of two Mal d 3 (non-specific lipid transfer protein) genes in the cultivated apple (Malus domestica)

    OpenAIRE

    Gao, Z. S.; Weg, van de, H; Schaart, J.G.; Meer, van der, D; Kodde, L.P.; Laimer, M; Breiteneder, H; K. Hoffmann-Sommergruber; Gilissen, L.J.W.J.

    2005-01-01

    Non-specific lipid transfer proteins (nsLTPs) of Rosaceae fruits, such as peach, apricot, cherry, plum and apple, represent major allergens for Mediterranean atopic populations. As a first step in elucidating the genetics of nsLTPs, we directed the research reported here towards identifying the number and location of nsLTP (Mal d 3) genes in the apple genome and determining their allelic diversity. PCR cloning was initially performed on two cultivars, Prima and Fiesta, parents of a core apple...

  16. Lady Mal-Beth

    OpenAIRE

    Guarinos, Virginia

    2007-01-01

    En la historia de Macbeth hay un personaje que ha compartido con el protagonista el interés del público. Es Lady Macbeth. Símbolo de maldad y de ambición, Lady Macbeth se ha convertido en un estereotipo que ha traspasado las barreras de su propio continente literario-teatral. Ello merece un acercamiento a su perfil, desde la perspectiva contemporánea de la Teoría Fílmica Feminista, así como a las diversas construcciones que de ella han elaborado los tres principales directores de cine que han...

  17. Endocrinopatías en gatos diagnosticadas entre marzo de 2003 y marzo de 2011 en el Hospital Escuela de Medicina Veterinaria de la Facultad de Ciencias Veterinarias, Universidad de Buenos Aires Endocrinopathies in cats diagnosed between March 2003 and March 2011 in the Veterinary school Hospital, Faculty of Veterinary Science, University of Buenos Aires

    Directory of Open Access Journals (Sweden)

    M.M Zapata

    2011-06-01

    Full Text Available El objetivo de este estudio fue analizar la frecuencia de presentación de endocrinopatías diagnosticadas en la Unidad de Endocrinología del Hospital Escuela en el período comprendido entre marzo de 2003 y marzo de 2011. Se revisaron las historias clínicas de 40 gatos diagnosticados con diversas endocrinopatías. La diabetes mellitus representó el 47,5% (19/40 de los casos, el hipertiroidismo el 20% (8/40, el hipotiroidismo el 15% (6/40 y el SC el 10% (4/40, siendo los desórdenes endócrinos de mayor presentación en el gato en nuestro medio. Las enfermedades endócrinas fueron más prevalentes en los gatos adultos y gerontes (45%, 18/40 por cada grupo, representando en los jóvenes el 10% (4/40, siendo en esta franja etárea el hipotiroidismo la enfermedad endócrina más prevalente (75%, 3/4. En adultos y gerontes la diabetes mellitus fue la enfermedad más prevalente seguida del hipertiroidismo, enfermedades que no se registraron en el grupo de gatos jóvenes. Por sexo la distribución fue levemente superior en machos (55% que en hembras (45%, siendo en ambos sexos la diabetes mellitus la enfermedad más prevalente. Se concluye que, al menos en el período evaluado, la diabetes mellitus es la enfermedad más diagnosticada en el gato en nuestro medio, contrariamente a lo comunicado en el hemisferio norte donde lo es el hipertiroidismo. Esta patología se encuentra en segundo lugar, siendo seguida por el hipotiroidismo.The aim of this study was to analyze the frequency of endocrinopathies in cats diagnosed in the Endocrinology Unit of the Veterinary School Hospital, FCV-UBA in the period understood between March, 2003 and March, 2011. There were checked the case histories of 40 cats that were attendant in the mentioned institution. From the total of cases, Diabetes Mellitus represented 47.5% (19/40, the Hyperthyroidism was 20% (8/40, Hypothyroidism 15% (6/40 and Cushing's syndrome 10% (4/40, being the endocrine disorders more frequent in

  18. Estado de mal epiléptico em crianças: experiência clínica com o difenilidantoinato de sódio por via parenteral

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    Antranik Manissadjian

    1961-01-01

    Full Text Available Os autores realizaram experiência clínica empregando o difenilidantoinato de sódio em crianças com estado de mal epiléptico. Analisam os resultados da ação do medicamento em função da idade, tempo de duração do estado de mal e presença, ou não, de hipertermia. Concluem pela inocuidade do medicamento e pela sua eficiência em um número de casos (72,3% suficiente para justificar a sua utilização como recurso terapêutico de escolha em casos de estado de mal epiléptico.

  19. Možnosti využití ITIL v prostředí malých a středních firem

    OpenAIRE

    Matějka, Marek

    2006-01-01

    Práce se zabývá možnostmi využití nejlepších praktik ITIL v prostředí malých a středních podniků (SMB). Hlavním smyslem je pak zhodnocení ITIL z pohledu SMB sektoru a nalezení styčných ploch, které jsou pro tyto firmy aplikovatelné. Jednotlivé kapitoly se pak věnují konkrétním cílům. První obsahová kapitola definuje pojmy a uvádí čtenáře do problematiky. Text se postupně zaměřuje na problematiku malých a středních firem, jejich ekonomické situace a manažerského přístupu. Další část je věnován...

  20. Portfolio management pro malé a střední společnosti v oblasti podnikání ICT

    OpenAIRE

    Altschmied, Martin

    2008-01-01

    Cílem práce je zařadit koncept IT Portfolio Management do kontextu strategického řízení firmy a dále navrhnout model IT Portfolio Managementu, který by byl universálně použitelný v malých a středních podnicích. Model zohledňuje odlišnosti malých a středních podniků a zestručňuje obecný postup implementace IT Portfolio Managementu popsaný v literatuře tak, aby byl lépe srozumitelný pro management takovýchto podniků. Přínos autora je zejména v syntéze teoretických poznatků s praktickými zkušeno...

  1. EL «MAL IDEOLÓGICO»: DESCRIPCIÓN Y CRÍTICA DE UNA POLÍTICA CONTRARIA A LA NATURALEZA HUMANA

    Directory of Open Access Journals (Sweden)

    Aquilino Cayuela Cayuela

    2012-01-01

    Full Text Available El mal ideológico consiste en situar ciertos ideales por encima de la persona humana real y concreta, y ha sido un elemento presente en las políticas totalitarias del siglo XX, particularmente aquellas que han desprotegido la vida y dignidad de los seres humanos. En la actualidad este mal ideológico se encarna en los impulsos políticos y legislativos que reducen el ámbito de protección de la vida y cuestionan de la dignidad de los estados de vida frágiles (neonatos, enfermos mentales, moribundos. El caso más importante en la España actual ha sido la reciente Ley Orgánica 2/2010, ley claramente ideológica, carente de argumentos que promocionen la humanidad y muy por el contrario una ley de plazos que sitúa la vida de los futuros ciudadanos en un peligroso espacio de desprotección y antepone dudosos derechos subjetivos y pulsiones ideológicas a una fuerte valoración de la dignidad humana y a los derechos fundamentales que de ella se derivan con son, en este caso la protección de la vida y la libertad de conciencia.

  2. Real-life practice study of the clinical outcome and cost-effectiveness of photodynamic therapy using methyl aminolevulinate (MAL-PDT) in the management of actinic keratosis and basal cell carcinoma.

    Science.gov (United States)

    Annemans, Lieven; Caekelbergh, Karin; Roelandts, Rik; Boonen, Hugo; Leys, Christoph; Nikkels, Arjen F; van Den Haute, V; van Quickenborne, L; Verhaeghe, Evelien; Leroy, Bernard

    2008-01-01

    Clinical trials have shown that photodynamic therapy using methyl aminolevulinate (MAL-PDT) is an effective treatment for actinic keratosis (AK), and nodular and superficial basal cell carcinoma (nBCC and sBCC) unsuitable for other available therapies. Economic evaluation models have shown that it is a cost effective intervention as well. The objectives of this prospective, observational, one arm study were (i) to verify in a real-life practice study the results obtained in previous clinical trials with MAL-PDT in the treatment of AK, nBCC and sBCC; (ii) to calculate the real-life cost of treatment and validate predictions from an economic evaluation model. Patients with AK and/or BCC were selected according to Belgian reimbursement criteria for treatment with MAL-PDT. Clinical response, cosmetic outcome and tolerability were assessed. MAL-PDT cost was calculated and compared to published model cost data. Data were collected from 247 patients (117 AK, 130 BCC). A complete clinical response was obtained for 83% of AK (85/102) and BCC (97/116) patients. A good or excellent cosmetic outcome was obtained for 95% of AK patients and 93% of BCC patients. Tolerability was good: only 2 patients withdrew for adverse events. Clinical results were similar to previous studies. Total cost of care per patient was euro 381 for AK, euro 318 for nBCC, and euro 298 for sBCC. Total cost per lesion was euro 58 for AK (identical to model prediction), euro 316 for nBCC and euro 178 for sBCC (both within 20% of model prediction). The clinical results of MAL-PDT in this real-life practice study confirm those demonstrated in previous clinical trials. Costs calculated from this study confirm predicted cost-effectiveness in the original model for MAL-PDT in the management of AK and BCC.

  3. Agostinho de Hipona: considerações sobre o mal e temas correlatos em De libero arbitrio = Augustine of Hippo: considerations on evil and correlated themes in De libero arbitrio

    Directory of Open Access Journals (Sweden)

    Pereira, Rosalie Helena de Souza

    2013-01-01

    Full Text Available Em várias obras, Agostinho aborda a questão do mal, mas é no diálogo De libero arbitrio que ele mais se estende sobre esse tema. A pergunta sobre a origem do mal conduz a argumentação do diálogo, introduzindo aos poucos o que vai se tornar a fórmula clássica do agostinismo, a saber, o intelecto aceita o que a fé esculpe. O mal surge quando há desordem, desmedida, excesso ou deficiência. O mal é o avesso da ordem natural. Cupiditas, a má libido, é uma desordem na alma, é o desejo por coisas passíveis de perda. O mal preexiste à promulgação da lei, já que deriva do pecado original. Do cogito de Agostinho – existir, viver e inteligir –, a principal e exclusiva qualidade do homem é a inteligência. Agostinho estabelece o axioma: a fé busca e a inteligência encontra. No entanto, para que haja inteligência, é necessária a iluminação, que, mais tarde, tomará contornos mais nítidos na conceituação da graça divina. Pela livre vontade, o ser humano peca. A graça é necessária ao livre-arbítrio da vontade humana para enfrentar eficazmente a luta contra o mal

  4. Surto de malária induzida entre usuários de drogas injetáveis Outbreak of malaria among injectable-drug users

    Directory of Open Access Journals (Sweden)

    Luiz Carlos Barradas Barata

    1993-02-01

    Full Text Available Em julho de 1990, foi registrado na cidade de Bauru, Estado de São Paulo, Brasil, um surto de malária envolvendo usuários de cocaína injetável. Uma ampla investigação epidemiológica, conduzida de 19 de julho a 13 de setembro, revelou que pelo menos 119 pessoas estavam envolvidas no surto, uma vez que haviam compartilhado seringas e agulhas com um ou mais casos confirmados nos 3 meses anteriores à ocorrência. Cento e duas dessas pessoas foram localizadas e entrevistadas, e destas, 99 foram submetidas a exame de gota espessa e 91 a exames sorológicos para malária. Foram confirmados por exame hemoscópico 21 casos de malária por P. vivax, e 3 outros tiveram exame sorológico positivo para P. vivax. O controle da transmissão foi obtido fornecendo-se cloroquina aos envolvidos no surto, numa dose inicial de 10 comprimidos, seguida de doses supressivas semanais de 2 comprimidos até que fosse identificado o último comunicante. Amostras de soro coletadas na ocasião revelaram, ao lado da malária, uma alta prevalência de infecções pelo HIV (58% e pelo vírus da hepatite B (40%. Foram discutidas as dificuldades para o controle do surto e a possibilidade da malária vir a se tornar uma doença endêmica entre usuários de drogas injetáveis, no Estado de São Paulo.Five cases of malaria were detected among cocaine users by the local health service in Bauru, a city with a population of 260,000, located 324 km from S. Paulo, Brazil, during the first three weeks of July 1990. Autochthonous malaria had not occurred in Bauru since 1978, and all the five cases denied having recently traveled to endemic areas. An extensive epidemiologic survey conducted from July 19 to September 13 revealed that the 5 cases were in fact part of a malaria outbreak among endovenous drug users. Moreover, at least 114 other people, who had in the last three months shared syringes and needles with one or more proved cases, were also involved in the outbreak. One

  5. Retardo no crescimento intrauterino, baixo peso ao nascer e prematuridade em recém-nascidos de grávidas com malária, na Colômbia

    Directory of Open Access Journals (Sweden)

    Alberto Tobón-Castaño

    2011-06-01

    Full Text Available INTRODUÇÃO: É frequente a associação da malária com complicações como prematuridade, retardo no crescimento intrauterino, baixo peso ao nascer e mortalidade infantil, efeitos pouco estudados em áreas hipoendêmicas para malaria. O objetivo deste estudo foi analisar a relação da malária gestacional com estes efeitos em recém-nascidosnuma região endêmica para malária na Colômbia, entre 1993 e 2007. MÉTODOS: Foram estudadas as características em 1.716 recém-nascidos num estudo de coorte. Fez-se seguimento em 394 gestantes com malária (27% por Plasmodium falciparum e 73% por P. vivax e 1.322 sem malária. RESULTADOS: Foi encontrada uma relação entre a exposição à malária na gestação e o risco maior de baixo peso ao nascer (RR = 1,37; 1,03-1,83, assim como estatura baixa (RR = 1,52; 1,25-1,85, retardo no crescimento intrauterino (RR = 1,29; 1,0-1,66 e prematuridade (RR = 1,68; 1,3-2,17. A frequência de nascimentos prematuros foi maior nas mães com malária por P. falciparum (77% que aquelas com P. vivax (RR = 1,77; IC 95%: 1,2-2,6. CONCLUSÕES: O baixo peso ao nascer e o retardo no crescimento foi associado com malária na gestação na Colômbia. A infecção por P. vivax foi relacionada com efeitos adversos sobre o recém-nascido, de modo semelhante em relação ao P. falciparum.

  6. Rozšíření a struktura populací střevle potoční (Phoxinus phoxinus) v povodí Malše

    OpenAIRE

    LUKEŠ, Václav

    2010-01-01

    This thesis was elaborated within the MSM 6007665801 research intention. The objective of the thesis was to create an overview of the distribution of Common Minnow in the basin of upper and middle reaches of the Malše River. Selected stretches of the Malše River, Černá River and Pohořský, Huťský, Tisový and Žďárský Brooks were monitored. These streams correspond to trout waters in their character. The field research was conducted in the years 2005?2008. Estimates of quantity and indexes of di...

  7. Biocontrol con Trichoderma spp. de Fusarium oxysporum causal del “mal de almácigos” en pre y post emergencia en cebolla

    OpenAIRE

    Sánchez, Aixa D.; Barrera, Viviana; Reybet, Graciela; Sosa, M. Cristina

    2015-01-01

    En Argentina, la “podredumbre basal” y el “mal de almácigos” causados por el complejo Fusarium spp. constituyen uno de los problemas más serios en cebolla. En este trabajo se estudió el uso de especies del género Trichoderma como agentes de control biológico (ACB) de F. oxysporum, causal del “mal de almácigos” en cebolla. Se identificaron y caracterizaron morfológica, cultural y fisiológicamente a 10 aislamientos de Trichoderma spp. del cepario de Fitopatología. Por secuenciación del gen TEF-...

  8. Malaria infection and the anthropological evolution Infecção por Malária e evolução antropológica

    Directory of Open Access Journals (Sweden)

    Sergio Sabbatani

    2010-03-01

    malária exerceu papel biológico chave, influenciando até o desenvolvimento antropológico. Os Plasmódios causadores da malária desenvolveram dois tipos de evolução, segundo um ponto de vista biológico, e filogenético. Em particular, os Plasmódios vivax, malariae, e ovale poderiam ter coevoluído com a espécie humana ou ter atingido esta durante as fases mais antigas da evolução do gênero HOMO. Por outro lado, o Plasmódio falciparum teria sido transmitido aos humanos por macacos num período mais recente, provavelmente entre o fim da Idade Mesolítica e o início da Neolítica. Os Autores mostram evidências biomoleculares, tanto diretas como indiretas, de infecção por malária, observada em indivíduos enterrados, reportando ao Mundo Antigo, e trazidas à luz no decorrer de escavações arqueológicas em alguns sítios relevantes Mediterrâneos. Nesta revisão da literatura, os autores organizam evidências modernas. Confirmam o papel da malária ao afetar a evolução das populações no Mediterrâneo. As pessoas que moram nas várias regiões do Mediterrâneo foram progressivamente influenciadas pela malária, ao longo do avanço desta doença. Além disso, as populações afetadas desenvolveram adaptações culturais, alimentares, e de comportamento, contribuindo para uma redução no risco da doença. Entretanto, pode ser que ambas modificações (as biológicas e as dos hábitos usadas pelos Plasmódios da malária, favoreceram a emergência de grupos de pessoas com maior resistência contra a malária. Todos estes fatores considerados reduziram o impacto demográfico, influenciando de uma maneira favorável o desenvolvimento em geral, e o crescimento da civilização.

  9. Nanotecnologia farmacêutica aplicada ao tratamento da malária Application of pharmaceutical nanotechnology to the treatment of malaria

    Directory of Open Access Journals (Sweden)

    Lúcio Figueira Pimentel

    2007-12-01

    Full Text Available Apesar do desenvolvimento tecnológico e científico, a malária permanece como um dos maiores problemas de saúde a serem combatidos. As estratégias modernas para o controle da doença prevêem ações conjuntas, como o combate do inseto vetor, diagnóstico rápido e preciso, garantia de terapêutica adequada, redução dos casos de resistência, além do desenvolvimento de novos agentes terapêuticos e vacina e através da otimização da ação de fármacos utilizados na atualidade. Os sistemas de liberação controlada de fármacos vêm recebendo atenção especial nesta área de pesquisa, com o desenvolvimento de estratégias para a veiculação de agentes bioativos e vacinas na forma de nanodispositivos tais como lipossomas, nanopartículas e micropartículas. Diversos nanossistemas já demonstraram eficácia na otimização de vacinas e quimioterápicos destinados ao controle da malária. Este artigo de revisão tem por objetivo avaliar o estado da arte na terapêutica da malária e demonstrar o potencial da nanotecnologia farmacêutica como ferramenta destinada ao combate da doença.In spite of living in a scientific and technological era, malaria continues to be one of the worldwide greatest health challenges. The state-of-the-art policy to keep malaria under control is expected to comprise joint-strategies, such as the vector control, fast diagnosis, therapeutic guarantee, resistance cutback, drug optimization and development of new therapeutic agents and vaccines. Nano and microcarrier systems have been receiving a special attention, including the development of strategies for carrying bioactive agents, vaccines through nanodevices, such as liposomes and nanoparticles, and microdevices, such as microparticles and microemulsions. Numerous nanosystems have already substantiated their effectiveness to optimize vaccines, insecticides, and chemotherapeutic agents applied to the control of malaria. This review is intended to explain the

  10. Prospective analysis of clinician accuracy in the diagnosis of benign anorectal pathology: the value of clinical information Análisis prospectivo de la precisión diagnóstica en la patología anorrectal benigna: importancia de la información clínica

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    Jaime Jimeno

    2012-03-01

    Full Text Available Aim: the prevalence of anorectal disorders in general population is high. The aim of this study was to analyze the influence of clinical symptoms on diagnostic accuracy for benign anorectal pathology among different specialists and evaluate the relationship between diagnostic accuracy and years of professional experience. Methods: seven typical cases were selected. In a first interview, participants were shown images and asked to make a diagnosis. Afterwards, images with additional information (clinical symptoms were used. Two groups (group 1 = general surgeons and group 2 = medical specialists who attended emergency department completed both phases of the study to analyze the influence of clinical symptoms on the final diagnosis. Results: forty four specialists were interviewed. The percentage of participants making a correct diagnosis in groups 1 and 2, respectively, was as follows: case 1 (perianal abscess: 100 vs. 80.6%, (p = 0.157; case 2 (fissure: 92.3 vs. 51.6% (p = 0.015; case 3 (thrombosed hemorrhoid: 92.3 vs. 74.2% (p = 0.321; case 4 (anal condyloma: 100 vs. 87.1% (p = 0.302; case 5 (rectal prolapse: 100 vs. 83.9% (p = 0.301; case 6 (prolapsed hemorrhoid: 92.3 vs. 29% (p = 0.001, and case 7 (fistula: 100 vs. 67.7% (p = 0.021. There were significant differences in the number of correctly diagnosed cases between groups (p Objetivo: la prevalencia de los trastornos anorrectales benignos en la población general es alta. El objetivo de este estudio es analizar la influencia de los síntomas clínicos en la precisión diagnóstica de la patología benigna anorrectal entre los diferentes especialistas y evaluar la relación entre el diagnóstico de la enfermedad y los años de experiencia profesional entre los profesionales participantes. Pacientes y métodos: se seleccionaron 7 casos típicos. En una primera entrevista, se mostró a los participantes las imágenes clínicas de cada caso y se les pidió que formularan un diagn

  11. Ajuste rápido de dosis de tapentadol en el tratamiento del dolor mal controlado Fast titration of tapentadol for the treatment of badly controlled pain

    OpenAIRE

    M. J. Sánchez del Águila; R. González López; A. D. Ballesteros Chaves; F. Robles Domínguez; L. F. Valdés Vilches; P. Alonso Atienza

    2012-01-01

    Introducción: el tapentadol es un nuevo fármaco de acción dual MOR/NRI, que actúa a nivel central, efectivo en el tratamiento del dolor moderado e intenso, que presenta un perfil de tolerabilidad mas favorable que otros opiáceos. Esto podría permitir una titulación rápida que permita un control precoz del dolor. Material y métodos: presentamos dos casos clínicos en los que se realiza una titulación rápida de la dosis de tapentadol en pacientes hospitalizados con dolor mal controlado. Este aju...

  12. Řízení informatiky v malých a středních podnicích

    OpenAIRE

    Šmerda, Miroslav

    2007-01-01

    Bakalářská práce pojednává o řízení informatiky vzhledem k nejvíce uznávaným rámcům. ITIL jako jeden z těchto rámců je pak blíže popsán a také porovnán s rámcem CobiT s ohledem na využití v malých a středních podnicích. Druhá část této práce je zaměřena na specifika řízení informačního systému v tomto sektoru ekonomiky.

  13. Efeito dos factores do hospedeiro e parasitários na susceptibilidade à Malária e gravidade da Doença

    OpenAIRE

    Monteiro, Maria Fernanda

    2012-01-01

    A malária é considerada como a doença parasitária mais séria em humanos, infectando cerca de 5 a 10% da população mundial, estimando-se entre 300 a 600 milhões de casos e mais de dois milhões de mortes, anualmente. Apesar da severidade da doença, a compreensão da variabilidade da resposta do hospedeiro à infecção (traduzida desde a infecção silenciosa até formas crónicas da doença, passando por quadros clínicos potencialmente fatais), continua a ser um dos grandes desafios da investigação méd...

  14. De la malédiction littéraire : entre mélancolie, pauvreté et persécution

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    Buata Malela

    2007-03-01

    Full Text Available Le dernier ouvrage de Pascal Brissette se propose de reconstituer le mythe de la malédiction littéraire sur une période allant du Moyen Âge au XIXe siècle (p. 16. Pour saisir la complexité d’un tel sujet, Pascal Brissette choisit un axe multidisciplinaire en joignant la sociologie de la littérature, la sociocritique des textes et l’histoire de la littérature (p. 17. Son but est de réfléchir à la fonction du malheur dans les processus de légitimation culturelle en étudiant les formes variées...

  15. Nanotecnologia farmacêutica aplicada ao tratamento da malária Application of pharmaceutical nanotechnology to the treatment of malaria

    OpenAIRE

    Lúcio Figueira Pimentel; Agenor Tavares Jácome Júnior; Vanessa Carla Furtado Mosqueira; Nereide Stela Santos-Magalhães

    2007-01-01

    Apesar do desenvolvimento tecnológico e científico, a malária permanece como um dos maiores problemas de saúde a serem combatidos. As estratégias modernas para o controle da doença prevêem ações conjuntas, como o combate do inseto vetor, diagnóstico rápido e preciso, garantia de terapêutica adequada, redução dos casos de resistência, além do desenvolvimento de novos agentes terapêuticos e vacina e através da otimização da ação de fármacos utilizados na atualidade. Os sistemas de liberação con...

  16. Grupo de Pesquisa mal-estar e bem-estar na docência = Research Group: burnout and well-being in teaching

    Directory of Open Access Journals (Sweden)

    Stobäus, Claus Dieter

    2007-01-01

    Full Text Available O presente artigo mostra a configuração e trabalhos relevantes do grupo de pesquisa, tanto em nível local, como nacional e internacional, revisando também elementos da temática do mal e bem-estar docente, bem tanto do ponto de vista teórico, como de achados obtidos em pesquisas, intervenções e apresentações já realizadas. Este tipo de abordagem já está entre os estudos mais desenvolvidos nestes últimos anos, pois aprofunda em aspectos pessoais e profissionais docentes. Apontam-se possíveis direções para o desenvolvimento do bem-estar no campo de trabalho do professor

  17. Mal de Hansen, anticorpos antifosfolípides e obstrução das artérias fibulares Leprosy, antiphospholipid antibodies and bilateral fibular arteries obstruction

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    Liz Wallin

    2009-04-01

    Full Text Available Pacientes com Mal de Hansen (MH podem se apresentar com quadro clínico e laboratorial sugestivo de doenças reumáticas, o que exige um exercício cuidadoso de diagnósticos diferenciais. Descreve-se aqui o caso de uma jovem com MH que se apresentou com lesões cutâneas sugestivas de vasculite, obstrução de vasos fibulares, FAN e anticorpos antifosfolípides positivos sem muitos estigmas da doença cutânea, ilustrando essa dificuldade.Patients with Hansen's disease (HD may present themselves with clinical and laboratorial features that resemble rheumatic disorders. This requires a careful exercise of differential diagnosis. We describe here a case of a young woman with HD that presented with vasculitic like lesions, fibular vessels obstruction, ANA and antiphospholipid antibodies without typical signs of cutaneous disease, illustrating this clinical difficulty.

  18. Teste de hemaglutinação na sorologia da malária humana empregando hemácias parasitadas pelo Plasmodium berghei

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    Maria Carmen Arroyo Sanchez-Ruiz

    1985-06-01

    Full Text Available Foi padronizado um teste de hemaglutinação para a sorologia da malária humana, com reagente constituído de suspensão de hemácias de camundongos infectadas pelo Plasmodium berghei e preservadas por fixação aldeídica. Em pacientes com parasitemia por P. falciparum ou P. vivax obteve-se uma sensibilidade de 98,9% nos 88 casos estudados, o teste apresentando títulos entre 40 e 640. Para o grupo de 476 soros de indivíduos não-maláricos, obteve-se uma especificidade de 96,0%. O teste apresentou elevada reprodutibilidade, mesmo para diferentes lotes de antígenos. Nos 200 soros, obtidos ao acaso, de indivíduos de área endêmica, o teste apresentou positividade de 48,5%, contra 88,0% do teste de imunofluorescência-IgG. A baixa positividade pode ser devida a que o teste de hemaglutinação detecta anticorpos IgM. Após tratamento com 2-mercaptoetanol, todos os soros de pacientes com parasitemia tornaram-se não reagentes. Em relação ao teste de imunofluorescência-IgG, o teste de hemaglutinação apresentou índice de co-positívidade de 0,989 para os soros de maláricos com parasitemia. Para os soros de não-maláricos o teste de hemaglutinação apresentou índice de co-negatividade de 0,969. Por outro lado, no grupo de soros de área endêmica, o índice de co-positividade foi de 0,528 e o de co-negatividade, de 0,833.A hemagglutination test is described for human malaria serodiagnosis with aldehyde-fixed Plasmodium berghei infected mouse erythrocytes. In patients with a P. falciparum or P. vivax patent parasitemia positive results were seen in 98.9% ofthe 88 cases tested. Titres rangedfrom 40 to 640. A 96.0% specificity wasfoundfor 476 non-malarialpatients. A close reproducibility was observed forthe test, even for dijferent reagent batches. The test was positive in 48.5% of 200 residents in malaria endemic areas, taken at random. These subjects showed 88.0% positivity of the IgG-immunofluorescence test. This lower positivity for

  19. Lugares de memoria y lugares de amnesia. La familia como colectivo amnésico en Os libros arden mal de Manuel Rivas

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    Anna Lammers

    2016-07-01

    Full Text Available The expression “historical memory” is dominating the political, social and cultural discourse in Europe for the last few years. This term is essentially used in Spain where it is linked to the events of the Spanish Civil War (1936-1939 and the Dictatorship of Franco (1939-1975. Memories of these historical events never lose their need to be remembered. The work of the Galician author Manuel Rivas contributes to the rediscovery of these historical memories. His novel Os libros arden mal (2006 can be seen as a complex and versatile panorama of those traumatic events. This article focuses with references to the concepts of social and cultural studies about collective memory on representations of the Spanish Civil War and the Franco dictatorship in the above-mentioned novel of Manuel Rivas. Identifying the lieux de memoire of one of its protagonist families, it examines the role of the family as a space of transmission and remembrance

  20. Reposição cirúrgico-ortopédica de implante mal posicionado: relato de caso Surgical-orthopedic repositioning of malpositioned implant: a case report

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    Luiz Carlos Ferreira da Silva

    2005-06-01

    Full Text Available A reabilitação bucal por meio da colocação de implantes dentários tem se tornado um procedimento freqüente da clínica odontológica. Falhas no planejamento ou na execução da técnica podem levar a casos onde, apesar de osseointegrado, o implante não apresenta condições de restauração satisfatória devido ao seu mal posicionamento. Diversos autores têm relatado a possibilidade de se utilizar osteotomias segmentares de maxila ou mandíbula para reposicionar um segmento alveolar com implante, mostrando que esta pode ser uma técnica efetiva e previsível para restaurar implantes em posição anatômica comprometida. O presente trabalho apresenta o caso clínico de uma paciente de 20 anos de idade onde foi realizada osteotomia segmentar de maxila associada à distração osteogênica para correção de um implante mal posicionado.Oral rehabilitation through dental implants has become a common procedure at dental practice. However, if the implant is placed in an inappropriate position either because of inadequate presurgical planning or poor surgical technique, it may be unrestorable in spite of osseointegrated. Many authors have reported the possibility of using segmental maxillary or mandibular osteotomies to reposition an alveolar segment with its implants. This can be an effective, predictable technique for restoring implants in a compromised anatomic position. This paper presents a case report describing the use of this procedure associated to distraction osteogeneis to reposition one malpositioned implant in a 20 years old girl.

  1. Avaliação do Sistema de Informações Hospitalares como instrumento para vigilância da malária na Amazônia Legal Brasil: 1998-2005

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    Erika Valeska Rossetto

    2013-01-01

    Full Text Available O Sistema de Informações Hospitalares do Sistema Único de Saúde (SIH/SUS é um sistema voltado para o gerenciamento de ambientes hospitalares. O objetivo deste trabalho foi avaliar o SIH/SUS como instrumento para vigilância da malária na Amazônia Legal. Método: Realizou-se a análise dos registros de internações por malária no SIH/SUS, na Amazônia Legal, no período de 01 de janeiro de 1999 a 31 de dezembro de 2005. A avaliação foi baseada no Updated Guidelinesfor Evaluating Public Health Surveillance Systems do Centers for Disease Control and Prevention. Resultados: As internações pormalária representavam 0,98% (118.775 do total das internações da Classificação Internacional de Doenças (CID 10, por local deresidência, na Amazônia Legal, sendo 41% (48.674 por malária não especificada (NE. Foram registrados 150 óbitos, sendo 100%por malária NE. A curva da taxa de internação é descendente, sendo de 0,96% em 1998, 0,60% em 2000 e 0,46% em 2005. As internações por malária NE custaram R$ 7.595.701,36 ao SUS. Conclusão: O conjunto dos resultados das avaliações dos atributos e a resposta que o sistema fornece para a efetiva vigilância do agravo tornam o sistema útil. Deve-se estabelecer uma rotina de exploração deste sistema como fonte de informação nos serviços de vigilância.

  2. Intoxicações por plantas diagnosticadas em ruminantes e equinos e estimativa das perdas econômicas na Paraíba Plant poisonings diagnosed in ruminants and horses and estimation of the economical losses in Paraíba

    Directory of Open Access Journals (Sweden)

    Tales S. Assis

    2010-01-01

    Full Text Available Foi realizado um levantamento dos surtos de intoxicações por plantas em ruminantes e equinos diagnosticados no Laboratório de Patologia Veterinária (LPV, do Hospital Veterinário da Universidade Federal de Campina Grande, Campus de Patos, Paraíba, no período de 2000-2007. Em bovinos 7,4% dos diagnósticos realizados pelo LPV foram intoxicações por plantas. Foram diagnosticadas intoxicações por Centhraterum brachylepis (um surto, Brachiaria spp. (um surto, Crotalaria retusa (dois surtos, Ipomoea batatas (um surto, Marsdenia sp. (um surto, gramíneas contendo nitratos e nitritos (um surto por Echinochloa polystachya e dois surtos por Pennisetum purpureum, Palicourea aeneofusca (um surto, Prosopis juliflora (três surtos, Nerium oleander (um surto e Mimosa tenuiflora (sete surtos. Na espécie ovina 13% dos diagnósticos foram intoxicações por plantas. Os surtos foram causados por Ipomoea asarifolia (quatro surtos, Brachiaria spp. (três surtos, Crotalaria retusa (dois surtos, Tephrosia cinerea (dois surtos, Panicum dichotomiflorum (um surto, Mascagnia rigida (um surto e malformações associadas à ingestão de Mimosa tenuiflora (20 surtos. Nos caprinos, 6,4% dos diagnósticos corresponderam à intoxicação por plantas. Sete surtos foram causados por Mimosa tenuiflora, um por Ipomoea asarifolia, um por Ipomoea carnea, um por Ipomoea riedelli, três por Prosopis juliflora, um por Arrabidaea corallina, dois por Aspidosperma pyrifolium, dois por Turbina cordata e um por Opuntia ficus-indica. Na espécie equina 14% das doenças diagnosticadas foram devidas a intoxicações por plantas, sendo 12 surtos por Crotalaria retusa e um por Turbina cordata. As perdas na Paraíba por plantas tóxicas são estimadas em 3.895 bovinos, 8.374 ovinos, 6.390 caprinos e 366 equinos, que representam uma perda econômica anual, por morte de animais, de R$ 2.733.097,00. São relatados alguns aspectos epidemiológicos, sinais clínicos e patologia de surtos de

  3. Benign childhood epilepsy with centro-temporal spikes: correlation between clinical, cognitive and EEG aspects Epilepsia benigna da infância com pontas centrotemporais: correlação entre aspectos clínicos, eletrencefalográficos e cognitivos

    Directory of Open Access Journals (Sweden)

    Lineu Corrêa Fonseca

    2007-09-01

    Full Text Available Benign childhood epilepsy with centro-temporal spikes (BECTS is a form of epilepsy with no demonstrable anatomical lesion showing spontaneous seizure remission. During the active phase of the disease the children may show cognitive deficits. The objective of this study was to assess, in children with BECTS, the relationship between clinical-EEG aspects and performance in the school performance test (SPT, Raven's progressive matrixes test and the Wechsler Intelligence Scale for Children (WISC-III. Forty-two 7 to 11 year old children were included and the following tests carried out: anamnesis, neurological examination, electroencephalogram (EEG, SPT, Raven's test and WISC-III. The children with BECTS had normal IQ values but showed inferior performance in the SPT more frequently than "healthy" children, paired with respect to age and maternal scholastic level. There was moderate positive correlation between WISC-III results and the age when the seizures started and the educational level of the parents. On the other hand, aspects linked to the epileptic nature of BECTS, such as the number of seizures, time since last seizure and the number and lateralization of the centro-temporal spikes on the EEG, showed no correlation with the neuropsychological tests.A epilepsia benigna da infância com pontas centrotemporais (EBICT é uma forma de epilepsia na qual não existem lesões anatômicas demonstráveis e há remissão espontânea das crises. Na fase ativa da epilepsia as crianças podem apresentar déficits cognitivos. O objetivo deste estudo foi avaliar, em crianças com EBICT, a relação entre aspectos clínico-eletrencefalográficos e o desempenho no teste de desempenho escolar (TDE, no teste das matrizes progressivas de Raven e na Escala Wechsler de Inteligência para Crianças (WISC-III. Foram incluídas 42 crianças de 7 a 11 anos de idade. Foram realizados: anamnese, exame neurológico, eletrencefalograma (EEG, TDE, teste de Raven e WISC

  4. Associação entre a contagem de linfócitos T CD4+ e a gravidade da neoplasia intra-epitelial cervical diagnosticada pela histopatologia em mulheres infectadas pelo HIV Association between CD4+ T-cell count and intraepithelial cervical neoplasia diagnosed by histopathology in HIV-infected women

    Directory of Open Access Journals (Sweden)

    Juliana Barroso Zimmermmann

    2006-06-01

    Full Text Available OBJETIVO: avaliar a associação entre a contagem de linfócitos T CD4+ e a gravidade da neoplasia intra-epitelial cervical em pacientes HIV positivas. MÉTODOS: estudo transversal no qual foram incluídas 87 pacientes infectadas pelo HIV, confirmado por testes sorológicos prévios. Todas eram portadoras do HPV cervical, diagnosticado por meio da reação em cadeia da polimerase. Foram realizados anamnese, exame físico e colposcopia de todas em pacientes. A biópsia do colo uterino foi realizada quando indicada pelo exame colposcópico. Os resultados histopatológicos foram classificados com neoplasia intra-epitelial de baixo grau (NIC I ou de alto grau (NIC II e II. A associação entre a contagem de linfócitos T CD4+ e a gravidade da lesão foi verificada por meio da comparação de médias utilizando a análise da variância (ANOVA. RESULTADOS: entre as 60 pacientes biopsiadas foram encontrados 24 casos (40,0% com NIC I, oito (13,3% NIC II, três (5% NIC III, 14 (23,3% pacientes somente com cervicite crônica e 11 (18,3% apresentando efeito citopático produzido pelo HPV, mas sem perda da polaridade celular. Isso equivale a 35 mulheres com lesão intra-epitelial de baixo grau (NIC I + HPV (58,3% e 11 (18,3% com lesão intra-epitelial de alto grau (NIC II + NIC III. A associação entre a média da contagem de linfócitos T CD4+ e a gravidade da lesão intra-epitelial cervical não foi significativa (p=0,901. CONCLUSÕES: não houve associação entre a contagem de linfócitos T CD4+ e a gravidade da lesão intra-epitelial do colo uterino, diagnosticada pelo exame histopatológico.PURPOSE: to evaluate association between CD4+ cell count and cervical intraepithelial lesion severity in HIV-infected women. METHODS: cross-sectional study of 87 HIV-infected patients which were confirmed by previous serologic examinations. All had cervical HPV diagnosed by polymerase chain reaction (PCR. All patients underwent anamnesis, physical examinations and

  5. MAl2O4:Eu3+红色荧光粉的制备及其发光性质研究%Synthesis and luminescent properties of MAl2 O4:Eu3+(M=Ca, Sr, Ba) red phosphor

    Institute of Scientific and Technical Information of China (English)

    刘娟; 王玮; 周立亚

    2014-01-01

    MAl2O4:Eu3+(M=Ca, Sr, Ba) red phosphors were synthesized by sol-gel method re-spectively.The optimum calcinations temperature for CaAl2 O4:Eu3+ phosphor is 900 ℃, the size of the particles are about 1 ~2 μm, and the luminous intensity reaches the maximum when the mol concentration of activator Eu3+ions increased to 4%;the optimum calcinations temperature for SrAl2 O4:Eu3+ red phosphor is 1 100 ℃, the size of the particles are about 3~4 μm, and the luminous intensity reaches the maximum when the mol concentration of activator Eu3+ ions increased to 4%;the optimum calcinations temperature for BaAl2 O4:Eu3+ Red Phosphor is 1 100 ℃, the size of the particles are about 4 ~5 μm, and the luminous intensity reaches the maximum when the mol concentration of activator Eu3+ ions increased to 2%.Upon excitation with 392 nm light, all the MAl2O4:Eu3+(M=Ca, Sr, Ba) powders show bright red emission due to the 4f-4f transitions of Eu3+ ions.The excitation and emission spectra showed that the phosphor can be effectively excited by ultraviolet light(392 nm) , nicely fitting in with the widely applied emission wavelengths of ultravio-let light-emitter diodes (LED) chips.The MAl2O4:Eu3+(M=Ca, Sr, Ba) phosphors may be good candidate phosphor for LED application.%采用溶胶-凝胶法分别制备MAl2 O4:Eu3+( M=Ca, Sr, Ba)系列红色荧光粉,并对所制备的样品进行了XRD、SEM以及荧光光谱等表征,结果表明:CaAl2 O4:Eu3+红色荧光粉的适宜焙烧温度为900℃,其粒径大小约1~2μm,当激活剂Eu3+的摩尔浓度增加到4%时,其发光强度达到最大;SrAl2 O4:Eu3+红色荧光粉的适宜焙烧温度为1100℃,其粒径大小约3~4μm,当激活剂Eu3+的摩尔浓度增加到4%时,其发光强度达到最大;BaAl2 O4:Eu3+红色荧光粉的适宜焙烧温度为1100℃,其粒径大小约4~5μm,当激活剂Eu3+的摩尔浓度增加到2%时,其发光强度达到最大。以392 nm 的近紫外光激发样品,MAl2 O4:Eu3+( M=Ca, Sr, Ba)

  6. 水稻内生成团泛菌YS19共质体形成差异表达蛋白MalE及其兼职功能%Symplasmata Formation Related MalE Protein and Its Moonlighting Functions in Rice Endophyte Pantoea agglomerans YS19

    Institute of Scientific and Technical Information of China (English)

    李倩倩; 熊小路; 牟昱飞; 易婷; 李二丽; 卢镇岳; 缪煜轩; 冯永君

    2012-01-01

    this protein was successfully obtained. Then, database searching with Mascot in the SWISS-Prot database was performed using the recorded peptide mass fingerprint data. It is found that among 53 peptides, there are 14 peptide masses matching to MalE from Enterobacter aerogenes, which is a protein belonging to the periplasmic maltose-binding protein family of the ATP-binding cassette transporters. Then the gene of the MalE protein was cloned from YS19, expressed in the E. Coli BL21 (DE3), and the recombinant protein was purified to homogeneity. Under stress (acid) treatments, the recombinant protein showed strong anti-aggregation ability, and even exhibited chaperone-like activity. This assay was achieved by comparing the quantity of the substrate proteins remaining in the supernatant under various denaturing acid conditions, where the aggregation of the substrate protein was effectively suppressed in the presence of the recombinant MalE protein. Far-UV circular dichroism spectroscopy examination on the purified MalE proteins under different pHs indicated that the global structures exhibited a sudden transition from a highly ordered conformation to a less ordered one. However, MalE was still capable of maintaining most of its secondary structures under these extreme acidic conditions (pHl~2). Finally, the Bis-ANS fluorescent probe technique was used to explore the effect of acid condition on the hydrophobic surfaces exposing of the protein. It is found that with the decrease of the pH value, the fluorescence intensity of the samples increased gradually, suggesting the MalE protein exposed the hydropbobic surfaces of the molecule to bind the substrates, implying the protein performed its chaperone activity via exposing its hydrophobic surfaces under acidic condition. MalE protein, originally found as a periplasmic maltose-binding protein of the ATP-binding cassette transporters, whose expression in YS19, however, far exceeds the amount being needed for transmembrane

  7. Ciencia prohibida... ciencia buscada (A propósito de La ciencia del bien y del mal de Javier Echeverría

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    Gómez Pin, Víctor

    2007-06-01

    Full Text Available A labyrinth was the infinite for Leibniz (who declares on several occasions that,as much from the angle of the infinite large as from that of the infinite small, infinity is nothing but a fiction in the attempts of thought to explain the phenomena. But another labyrinth was also for him the problem of the evilness, together with the correlative problem of goodness. Used, since he was a young mathematician, to the Leibnizian puzzle of the infinite, Javier Echeverría faces now the second labyrinth. And he approaches the subject by restoring the biblical myth of the tree that hides the mystery. Taken implicitly the opposite point of view that leads Kant to assert the intrinsic division of the reason, Echeverría, from the very title of his book, aims at goodness and evilness as effective goals for science. In this paper we discuss some implications of Echeverría’s bet.

    Un laberinto era el infinito para Leibniz (quien afirma en varias ocasiones que tanto lo infinitamente grande como lo infinitamente pequeño no son sino ficciones para el pensamiento que busca la explicación de los fenómenos pero laberinto era asimismo, para él, la cuestión del mal, indisociable de problema del bien. Curtido, desde sus años de joven matemático, en el leibniziano puzzle del infinito y el continuo, Javier Echeverría se confronta ahora al segundo laberinto. Y lo hace restaurando el bíblico relato del árbol cuyo fruto escondería el misterio. Tomando implícitamente una vía opuesta a la que conduce a la kantiana división de la razón, Echeverría apunta a hacer de la polaridad bien-mal objeto de efectiva ciencia. En este escrito discutimos alguna de las implicaciones de su apuesta.

  8. Spectroscopic Properties of Novel Aromatic Metal Clusters: NaM4 (M=Al, Ga, In) and their Cations and Anions

    Energy Technology Data Exchange (ETDEWEB)

    Balasubramanian, K; Zhao, C

    2004-03-17

    The ground and several excited states of metal aromatic clusters, namely NaM4 and NaM{sub 4}{sup {+-}} (M=Al, Ga, In) clusters have been investigated by employing complete activespace self-consistent-field (CASSCF) followed by Multi-reference singles and doubles configuration interaction (MRSDCI) computations that included up to 10 million configurations and other methods. The ground states NaM{sub 4}{sup -} of aromatic anions are found to be symmetric C{sub 4v} ({sup 1}A{sub 1}) electronic states with ideal square pyramid geometries. While the ground state of NaIn4 is also predicted to be a symmetric C{sub 4v} ({sup 2}A{sub 1}) square pyramid, the ground state of the NaAl4 cluster is found to have a C{sub 2v} ({sup 2}A{sub 1}) pyramid with a rhombus base and the ground state of NaGa{sub 4} possesses a C{sub 2v} ({sup 2}A{sub 1}) pyramid with a rectangle base. In general these structures exhibit 2 competing geometries, viz., an ideal C{sub 4v} structure and a distorted rhomboidal or rectangular pyramid structure (C{sub 2v}). All of the ground states of the NaM{sub 4}{sup +} (M= Al, Ga, In) cations are computed to be C{sub 2v} ({sup 3}A{sub 2}) pyramids with rhombus bases. The equilibrium geometries, vibrational frequencies, dissociation energies, adiabatic ionization potentials, adiabatic electron affinities for the electronic states of NaM{sub 4} (M=Al, Ga, In) and their ions are computed and compared with experimental results and other theoretical calculations. On the basis of our computed excited states energy separations, we have tentatively suggested assignments to the observed X and A states in the anion photoelectron spectra of Al{sub 4}Na{sup -} reported by Li et al. The X state can be assigned to a C{sub 2v} ({sup 2}A{sub 1}) rhomboidal pyramid. The A state observed in the anion spectrum is assigned to the first excited state ({sup 2}B{sub 1}) of the neutral NaAl{sub 4} with the C{sub 4v} symmetry. The assignments of the excited states are consistent with

  9. Nota sobre surto de malária em usuários de drogas injetáveis Note on the malaria outbreak in users of injectable drugs

    Directory of Open Access Journals (Sweden)

    Luiz Carlos Barradas Barata

    1990-08-01

    Full Text Available Relata-se surto de malária por Plasmodium vivax entre usuários de drogas injetáveis, detectado na cidade de Bauru, Estado de São Paulo, Brasil. Até julho de 1989 12 casos haviam sido confirmados pelo exame de gota espessa, e 20 outros contactantes suspeitos estavam sendo investigados. Todos os casos relataram uso freqüente de cocaína injetável, compartilhando seringas e agulhas, e negaram viagens por áreas endêmicas de malária.An outbreak of Plasmodium vivax malaria among drug addicts in Bauru, S. Paulo State, Brazil, is reported. Until July 1989,12 cases had been confirmed by thick smear examinations and 20 contacts were being investigated. All of them reported frequent use of intravenous cocaine and sharing of needles and syringes but deny having travelled through endemic malarial areas.

  10. Alterações clínicolaboratoriais em pacientes com malária por Plasmodium vivax e deficiência de glicose-6-fosfato desidrogenase tratados com 0,50mg/kg/dia de primaquina

    OpenAIRE

    Silva Mônica C.M.; Santos Eliane B.; Costa Elenild G.; S. Filho Manoel G.; Guerreiro João F.; Póvoa Marinete M

    2004-01-01

    O efeito adverso da primaquina na dose de 0,50mg/kg/dia foi investigado em onze pacientes com malária vivax (três com deficiência de glicose-6-fosfato desidrogenase). Alterações clínicas e laboratoriais indicaram hemólise aguda apenas nos enzimopênicos, o que fez com que o tratamento fosse interrompido. Nossos resultados sugerem a necessidade do emprego de um teste de triagem para a deficiência de G6PD em áreas endêmicas de malária vivax a fim de se evitar complicações causadas pelo uso da pr...

  11. Problémy vyplývající z rozdílů české účetní legislativy a IFRS pro malé a střední podniky

    OpenAIRE

    Pazourková, Radka

    2011-01-01

    Předmětem diplomové práce je definovat rozdíly ve vykazování účetních informací podle českých účetních předpisů, podle standardního souboru IFRS a dle IFRS pro malé a střední podniky a vyčíslení nákladů a vymezení přínosů přechodu na vykazování účetních informací dle IFRS pro malé a střední podniky. Object of the thesis is to define differences in financial reporting according to the Czech Accounting Standards and to the standard file International Financial Reporting Standards and to the ...

  12. Influência da malária assintomática em parâmetros de crescimento e desenvolvimento em crianças e jovens de uma região rural de Moçambique

    OpenAIRE

    Domingos Madeira, Aspácia

    2011-01-01

    Moçambic registra una alta prevalença de malària amb un elevat índex de parasitèmia assintomàtica, però no hi ha estudis coneguts sobre la seva relació amb els diferents components del desenvolupament humà. L’objectiu va ser estudiar les característiques de creixement i desenvolupament dels nens, nenes i adolescents amb malària assintomàtica de les zones rurals de Calanga. L’estudi, de caràcter retrospectiu, es va portar a terme en una mostra de 351 subjectes d’ambdós, dividits en grups de 5...

  13. Flashback. El tiempo de los gitanos (Kusturica). Quieto, muere, resucita (Kanevski). Boom, Boom (R. Vergés). Henry, retrato de un asesino (Me Naugthon). La vida privada de Sherlock Holmes (B. Wilder). Sed de mal (Welles)

    OpenAIRE

    Nogueira, Xosé; Alonso Quintás, Enrique; Arias, Dany

    1992-01-01

    Nogueira, X.; Alonso Quintás, E.; Arias, D. (1992). Flashback. El tiempo de los gitanos (Kusturica). Quieto, muere, resucita (Kanevski). Boom, Boom (R. Vergés). Henry, retrato de un asesino (Me Naugthon). La vida privada de Sherlock Holmes (B. Wilder). Sed de mal (Welles). Vértigo. Revista de cine. (2):3-8. http://hdl.handle.net/10251/42914. 3 8 2

  14. INTERVENCIÓN FAMILIAR PARA EL MANEJO PSICOLÓGICO EN PACIENTES ONCOLÓGICOS CON MAL PRONÓSTICO EN EL HOSPITAL DE LA MISERICORDIA

    Directory of Open Access Journals (Sweden)

    Martha Restrepo Forero

    2004-06-01

    Full Text Available Se diseñó un programa fundamentado en el modelo cognitivo conductual de Inoculación de Estrés e intervención en duelo anticipatorio basado en cuatro tareas. El programa fue aplicado a tres pacientes con mal pronóstico del Servicio de Oncohematología del Hospital de la Misericordia y a sus familias. Por medio de estudio de caso, se describieron factores de riesgo y de protección así como respuestas frente a dicha intervención. El análisis cualitativo de casos arrojó la descripción de respuestas a pérdidas previas no elaboradas, pautas de comunicación deficiente en uno de los casos, y reconocimiento de apoyo al interior de cada familia. Según el reporte de los participantes, la intervención permitió la expresión de sentimientos, la reflexión sobre el sentido de la vida, incremento de posibilidades y habilidades de comunicación y orientación hacia la solución de problemas y toma de decisiones.

  15. Sequencing of the bicistronic genome segments S7 and S9 of Mal de Río Cuarto virus (Fijivirus, Reoviridae) completes the genome of this virus.

    Science.gov (United States)

    Guzmán, F A; Distéfano, A J; Arneodo, J D; Hopp, H E; Lenardon, S L; del Vas, M; Conci, L R

    2007-01-01

    The nucleotide sequences of genomic segments S7 and S9 of Mal de Río Cuarto virus (MRCV, Fijivirus group II) have been determined, thus completing the entire genome sequence of the virus. These segments showed a non-overlapping bicistronic structure, as in other members of the genus. MRCV S7 ORF-1 had a length of 1086 bp and encoded a 41.5 kDa putative polypeptide, whereas MRCV S7 ORF-2 had a length of 930 bp and encoded a 36.8 kDa putative polypeptide. Proteins of 39 and 20.5 kDa were predicted for the 1014 bp long MRCV S9 ORF-1 and the 537 bp long MRCV S9 ORF-2, respectively. The terminal 5' and 3' sequences of both segments were 5'AAGUUUUU3' and 5'CAGCUnnnGUC3', respectively. Specific imperfect inverted repeats of each segment were identified. Comparison of the predicted proteins with those of related virus genome segments counterparts in maize rough dwarf virus (MRDV) and rice black streaked dwarf virus (RBSDV), showed 64.5-44.3% identities. These values are lower than those resulting from comparisons between MRDV and RBSDV. The topology of the trees obtained using the complete nucleotide and amino acid sequences of MRCV S7 and MRCV S9 was consistent with the analysis of the other MRCV segments previously published.

  16. Pembuatan Strategic Dashboard untuk Mengidentifikasi dan Mengukur Potensi Tingkat Kesehatan Lembaga Keuangan Syariah Baitul Mal Wat Tamwil (BMT dengan Metode PEARLS Studi Kasus APEX

    Directory of Open Access Journals (Sweden)

    Jeanny Mareta Daud

    2012-09-01

    Full Text Available BMT (Baitul Mal Wat Tamwil tidak diakui sebagai non-bank lembaga keuangan, pada prinsipnya, lembaga BMT harus berfungsi sebagai lembaga intermediasi yang mengelola dana dari, untuk dan oleh masyarakat. BMT mencakup konsep pembiayaan kredit keuangan, jasa, asuransi simpananserta bagi masyarakat miskin dalam kegiatan ekonomi dan Pemerintah subsisten. Idealnya dengan mengintegrasikan konsep fungsi sosial, fungsi bisnis dalam satu wadah telah didirikan lembaga-lembaga penegakan hukum di lembaga-lembaga keuangan mikro syariah. APEX adalah lapis kedua (kedua lembaga tier atau organisasi yang mendistribusikan dana (baik dari hibah, pinjaman atau jaminan yang berperan untuk melayani anggota melalui sistem Informasi dan Komunikasi (TIK yang terintegrasi dalam lingkup nasional. APEX menjadi permukiman dan badan hukum akan mengetahui dan menganalisis kesehatan setiap anggota BMT. Pada dasarnya kesehatan penilaian diciptakan oleh World Council of serikat kredit (WOCCU adalah Mutiara (Perlindungan, Efektif, Aset, Tingkat pengembalian dan biaya, Likuiditas dan Tanda pertumbuhan. Hasil telah dilakukan dengan pembuatan aplikasi PEARLS dan pembuatan Dashboard PEARLS memudahkan pihak Executive untuk mengidentifikasi dan mengukur potensi tingkat kesehatan LKMS BMT secara strategis dan efektif dengan  menggunkanan metode PEARLS.

  17. Simulace malé větrné elektrárny se Savoniovým-Darrieovým rotorem

    OpenAIRE

    Hořava, Pavel

    2014-01-01

    Tato diplomová práce se zabývá simulací malé větrné elektrárny se Savoniovým-Darrieovým rotorem. V teoretické části je na základě teorie, kterou vytvořil německý fyzik Albert Betz, odvozen výkon modelované elektrárny a také činitel výkonu. V této části je také podrobně popsán postup návrhu modelu větru. Praktická část práce je pak zaměřena na vytvoření samotného modelu hybridní větrné elektrárny s vertikální osou otáčení DS300, přičemž pro modelování je zvolen Matlab/Simulink. Pomocí tohoto m...

  18. Návrh malé větrné elektrárny se Savoniovým rotorem

    OpenAIRE

    Foltýn, Petr

    2009-01-01

    Tato bakalářská práce se zabývá návrhem konstrukčního řešení větrné elektrárny se Savoniovým rotorem. V první části je souhrn teoretických poznatků, které mají vést k optimální konstrukci větrného energetického zdroje. V druhé části je vypracován konkrétní návrh malé větrné elektrárny včetně 3D modelu a konstrukčních výkresů zpracovaných v programu Autodesk Inventor Professional 2009. This Bachelor’s thesis deals with proposal of constructional solving of wind turbine system with Savonius ...

  19. Caminhos de um mal-estar de civilização: reflexões intelectuais norte-americanas para pensar a democracia e o negro no Brasil

    Directory of Open Access Journals (Sweden)

    Elizabeth Cancelli

    2010-05-01

    Full Text Available

    Este trabalho tem como objetivo buscar eixos de reflexão desenvolvidos nos Estados Unidos e que foram importantes para repensar a questão da democracia e da cultura no Brasil, especialmente no que diz respeito à inclusão social do negro e à construção de uma identidade brasileira. Assim, as releituras da herança da escravidão verificadas no Sul norte-americano nas primeiras décadas do século XX e o encorajamento para a redefinição da democracia, ocorridos no auge da guerra fria e da cultural war, serão contemplados para a recuperação de vertentes importantes do pensamento brasileiro e sua inserção nos debates em torno desse “mal-estar de civilização”.

  20. Analysis to the mal - operation of the differential operation in the induced draft fan%引风机差动保护误动原因分析

    Institute of Scientific and Technical Information of China (English)

    林立平

    2012-01-01

    分析了一起电厂引风机在启动过程中差动保护动作事故,根据电动机电源侧及中性点侧电流相量及现场的实际情况,排除电流互感器饱和引起二次电流畸变造成差动保护误动,并指出电动机一次电缆相序排列错误是导致这次事故的直接原因。分析了HN--2041D微机电动机保护装置在此次事故中的动作情况。%The paper analyzes a differential protection operation fault during the start period in the induced draft fan in the power plant. According to the motor power supply side and current vector in the neutral point side and the field practical situation, it can be eliminated that the differential protection fault mal - operation caused by the second order current distortion brought about by the current transformer saturation. The paper presents the arrangement fault of the motor first order cable phase sequence is the direct cause to the accident and analyzes the operation situation of the HN -2041D microcomputer motor protection devices in this accident.

  1. In vivo subcellular localization of Mal de Rio Cuarto virus (MRCV) non-structural proteins in insect cells reveals their putative functions

    Energy Technology Data Exchange (ETDEWEB)

    Maroniche, Guillermo A.; Mongelli, Vanesa C.; Llauger, Gabriela; Alfonso, Victoria; Taboga, Oscar [Instituto de Biotecnologia, CICVyA, Instituto Nacional de Tecnologia Agropecuaria (IB-INTA), Las cabanas y Los Reseros s/n. Hurlingham Cp 1686, Buenos Aires (Argentina); Vas, Mariana del, E-mail: mdelvas@cnia.inta.gov.ar [Instituto de Biotecnologia, CICVyA, Instituto Nacional de Tecnologia Agropecuaria (IB-INTA), Las cabanas y Los Reseros s/n. Hurlingham Cp 1686, Buenos Aires (Argentina)

    2012-09-01

    The in vivo subcellular localization of Mal de Rio Cuarto virus (MRCV, Fijivirus, Reoviridae) non-structural proteins fused to GFP was analyzed by confocal microscopy. P5-1 showed a cytoplasmic vesicular-like distribution that was lost upon deleting its PDZ binding TKF motif, suggesting that P5-1 interacts with cellular PDZ proteins. P5-2 located at the nucleus and its nuclear import was affected by the deletion of its basic C-termini. P7-1 and P7-2 also entered the nucleus and therefore, along with P5-2, could function as regulators of host gene expression. P6 located in the cytoplasm and in perinuclear cloud-like inclusions, was driven to P9-1 viroplasm-like structures and co-localized with P7-2, P10 and {alpha}-tubulin, suggesting its involvement in viroplasm formation and viral intracellular movement. Finally, P9-2 was N-glycosylated and located at the plasma membrane in association with filopodia-like protrusions containing actin, suggesting a possible role in virus cell-to-cell movement and spread.

  2. Filosofía del mal y memoria, de Alejandro Forero Cuellar, Iñaki Rivera Beiras, Héctor Silveira Gorski

    Directory of Open Access Journals (Sweden)

    Sebastián Cabezas Chamorro

    2012-09-01

    Full Text Available La obra que aquí se comenta, es el producto de la sociedad formada entre el Observatori del Sistema Penal i els Drets Humans de la Universitat de Barcelona (OSPDH, el Máster oficial de Criminología y Sociología Jurídico-Penal de la misma casa de estudios y la editorial Anthropos-Siglo XXI.Precisamente en el marco de las actividades del OSPDH, en invierno del año 2010 se realizó el seminario “Filosofía del Mal y Memoria”. En dicha oportunidad participaron como ponentes Roberto Bergalli, Sebastian Scheerer, Manuel Reyes Mate y Luigi Ferrajoli, cuyas exposiciones son revisadas en esta obra. Importante es destacar que esta obra está compuesta no sólo por las disertaciones de ellos, sino que también por las intervenciones en el debate de los participantes del seminario; de ahí que este trabajo sea la reproducción exacta de todo lo allí sucedido, lo cual en definitiva explica, la profundidad y la riqueza de su contenido, más allá de la brevedad del texto. 

  3. Návrh využití nástrojů Business Intelligence pro potřeby malé firmy

    OpenAIRE

    Stryka, Lukáš

    2008-01-01

    Tato diplomová práce se zabývá analýzou stávajících procesů probíhajících v malé softwarové firmě. Na základě vyhodnocení slabých stránek jsou navržena rozšíření informačního systému o nový modul pro on-line prodej produktů s možností okamžité bezhotovostní online úhrady. Dále je navrženo rozšíření informačního systému o nástroje Business Intelligence, které by měli pomoci zefektivnit marketingové strategie této firmy. This Diploma Thesis deals with analysis of the current processes in sma...

  4. Transmisión del Mal de Río Cuarto virus por ninfas de primer y tercer estadio de Delphacodes kuscheli Transmission of Mal de Río Cuarto virus by first and third-instar nymphs of Delphacodes kuscheli

    Directory of Open Access Journals (Sweden)

    Joel Arneodo

    2005-02-01

    Full Text Available Se comparó la capacidad de ninfas de primer y tercer estadío de Delphacodes kuscheli Fennah (Hemiptera: Delphacidae para adquirir y posteriormente transmitir el Mal de Río Cuarto virus (MRCV, bajo condiciones controladas. Ninfas I y III avirulíferas se alimentaron separadamente de plantas de trigo infectadas durante 48 horas, para luego ser colocadas en subgrupos de tres individuos sobre plantas de trigo sanas. Se realizaron transmisiones seriales utilizando períodos de inoculación de 24 horas. Ambos estadií os lograron adquirir y transmitir el MRCV, pero se evidenció una mayor cantidad de subgrupos infectivos cuando la adquisición se efectuó como ninfas I, así como una disminución significativa en la duración del período de latencia del virus respecto de los insectos que adquirieron el MRCV durante el tercer estadio ninfal.The ability of first and third-instar Delphacodes kuscheli Fennah (Hemiptera: Delphacidae nymphs to acquire and transmit Mal de Río Cuarto virus (MRCV, under controlled conditions, was investigated. First and third-instar nymphs were allowed acquisition feeding separately on infected wheat plants for 48 hours. The insects were then placed in groups of three for serial transmissions to healthy wheat plants, using inoculation periods of 24 hours. Both instars of D. kuscheli were demonstrated to acquire and subsequently transmit the virus. Nevertheless, transmission trials showed highest transmission efficiency and shortest latent period when MRCV was acquired by first-instar nymphs.

  5. Oral and maxillofacial biopsied lesions in Brazilian pediatric patients: a 16-year retrospective study = Biópsias de lesões orais e maxilo-faciais em pacientes pediátricos brasileiros: estudo retrospectivo de 16 anos

    Directory of Open Access Journals (Sweden)

    Mouchrek, Monique Maria Melo

    2011-01-01

    Conclusão: Este estudo mostra uma tendência semelhante à relatada em estudos anteriores sobre as lesões mais freqüentes na região oral e maxilo-facial na população pediátrica. A maioria das lesões detectadas foram benignas, enquanto as malignas foram diagnosticadas em um número muito reduzido de pacientes

  6. Analysis of the risk factors for incidental carcinoma of the prostate in patients with benign prostatic hyperplasia Análise dos fatores de risco para o diagnóstico do carcinoma incidental da próstata em pacientes com hiperplasia prostática benigna

    Directory of Open Access Journals (Sweden)

    Alberto Azoubel Antunes

    2006-01-01

    ática benigna. MÉTODOS: O estudo compreendeu a análise retrospectiva de 218 pacientes. Após o tratamento cirúrgico, os pacientes com achado de carcinoma incidental da próstata foram comparados com os pacientes sem este achado. As variáveis pré-operatórias analisadas foram idade, toque retal, PSA, densidade do PSA, volume prostático e biópsia prostática pré-operatória. Também foram determinados a sensibilidade, especificidade, valor preditivo positivo e valor preditivo negativo do toque retal e do PSA para o diagnóstico do carcinoma incidental da próstata. RESULTADOS: Treze (6.2% dos 218 pacientes apresentaram carcinoma incidental da próstata. Oito (61.5% deles foram classificados com T1a e 5 (38.5% como T1b. Apenas a idade avançada (p=0.003 e a presença de um toque retal suspeito (p=0.016 se relacionaram estatisticamente com este achado na peça cirúrgica. A sensibilidade, especificidade, valore preditivo positivo e negativo para o diagnóstico de carcinoma incidental da próstata foram de 23.0%, 96.6%, 30.0%, 95.2% para a presença de um toque retal suspeito e 85.0%, 34.1%, 7.5% e 97.2% para um valor de PSA maior que 4.0 ng/ml respectivamente. A exatidãos dois métodos foi de 92.2% e 37.1% respectivamente. CONCLUSÕES: A idade avançada e a presença de um toque retal suspeito representam os fatores de risco mais importantes para o diagnóstico de carcinoma incidental da próstata.

  7. Heterogeneity of malaria prevalence in alluvial gold mining areas in Northern Mato Grosso State, Brazil Heterogeneidade da prevalência de malária em garimpos do norte de Mato Grosso, Brasil

    Directory of Open Access Journals (Sweden)

    Alisson Flávio Barbieri

    2007-12-01

    Full Text Available This paper analyzes factors affecting the risk of malaria among individuals working in wildcat gold mining camps (garimpos in northern Mato Grosso State in the Brazilian Amazon. Historically, such mining camps have the locations with the highest malaria prevalence in the Brazilian Amazon. However, little attention has focused on understanding the disease from the internal perspective of the mining camps themselves, such as the mining population's characteristics and its spatial organization. This paper adopts a stepwise logistic model to identify spatial, occupational-exposure, and cultural factors that affect malaria prevalence. According to the results, differences among individuals working and/or living in the gold mining areas could produce different exposure to the disease and thus to different risk of malaria prevalence. Understanding these differences may provide an important tool for identifying risk profiles in the gold mining and related population and for informing programs for prevention and treatment of malaria in the Amazon.O artigo analisa fatores que afetam o risco de malária entre garimpeiros de ouro no norte de Mato Grosso, Brasil. Historicamente, os garimpos apresentam a maior prevalência de malária da Amazônia Legal brasileira. Entretanto, até o momento houve pouca investigação no sentido de compreender a doença desde a perspectiva interna dos próprios garimpos, ou seja, através das características da população garimpeira e da sua organização espacial. O artigo adota um modelo logístico stepwise para identificar fatores territoriais, culturais e de exposição ocupacional que afetam a prevalência da malária. Com base nos resultados, diferenças entre indivíduos que trabalham e/ou vivem nas áreas de garimpo poderiam produzir variações na exposição à doença, levando a um risco diferenciado de prevalência de malária. A compreensão dessas diferenças pode representar uma ferramenta importante para

  8. A retrospective analysis of real-life practice of off-label photodynamic therapy using methyl aminolevulinate (MAL-PDT) in 20 Italian dermatology departments. Part 1: inflammatory and aesthetic indications.

    Science.gov (United States)

    Calzavara-Pinton, Pier Giacomo; Rossi, Maria Teresa; Aronson, Erica; Sala, Raffaella

    2013-01-01

    Experimental investigations have demonstrated that photodynamic therapy (PDT) with methyl aminolevulinate (MAL) may be a useful treatment in several inflammatory skin disorders and aesthetic indications. To assess the effectiveness, tolerability and safety of off-label MAL-PDT in daily clinical practice in 20 Italian hospital centers, a retrospective observational study of medical records of patients treated for off-label inflammatory and aesthetic indications was carried out. In all patients standard treatment options had been either ineffective, unacceptably toxic, or medically contraindicated. Clinical data regarding 221 patients affected by 22 different diseases were collected. The most common off-label indication was acne vulgaris, with >75% improvement in 72.8% of patients. Other disorders of the sebaceous gland, i.e. acne rosacea, hidradenitis suppurativa and sebaceous hyperplasia, were less responsive. Alopecia areata did not show any improvement. Granuloma annulare and necrobiosis lipoidica showed marked or moderate response in the majority of treated patients. The rate of patients with complete remission was lower for inflammatory skin disorders with hyperkeratosis, i.e. psoriasis (6/17) and porokeratosis (3/16). The efficacy for lichenoid dermatoses was dependent on the clinical variant (erosive and scleroatrophic were more responsive than hypertrophic). Only 1 of 6 patients with Zoon balanitis had a marked improvement. MAL-PDT of venous leg ulcers, photo-aging and hypertrophic scars led to a marked remission in 3/5, 3/6 and 5/8 patients, respectively. The treatment had to be interrupted because of strong pain and burning in 24 patients. Long term adverse events were not registered. Most patients with marked improvement had lasting remission with overall excellent cosmetic outcomes. The present findings demonstrate a high interest in off-label uses of MAL-PDT for inflammatory skin disorders. According to the observed clinical responses, safety, and

  9. Agentes etiológicos de onicomicosis diagnosticadas en el laboratorio de micología médica de la Universidad de Costa Rica Etiological agents of onychomycosis diagnosed in the medical mycology laboratory of the University of Costa Rica

    Directory of Open Access Journals (Sweden)

    Ingrid Salas-Campos

    2012-06-01

    Full Text Available Justificación y objetivos: Entre las onicodistrofias, la onicomicosis es la afección más frecuente. Esta infección no solo representa un problema estético para el paciente, sino que puede afectar sus actividades diarias. Para el dermatólogo se hace indispensable realizar el diagnóstico diferencial, por lo que el laboratorio de micología médica es de gran ayuda para este propósito. En cuanto a los agentes etiológicos incriminados, los dermatofitos son los más frecuentes; sin embargo, otros hongos filamentosos no dermatofitos se han aislado, cuya sensibilidad a los antimicóticos es menor. En este trabajo se estudió la frecuencia de las onicomicosis diagnosticadas en el laboratorio de Micología Médica de la UCR durante cuatro años, según edad y sexo de los pacientes, así como agentes etiológicos identificados. Métodos: Se incluyó a todos los pacientes que solicitaron el servicio de acción social que brinda la sección de Micología Médica, Facultad de Microbiología, Universidad de Costa Rica, entre enero del 2007 a diciembre del 2010 y que presentaban alteraciones ungueales sospechosas de onicomicosis. Se registró la edad y sexo de los pacientes y las muestras se procesaron por examen directo y cultivo. Resultados: Se procesaron 431 muestras de uñas, el 85,4% eran de pie y el 14,6% de mano, la edad promedio de los pacientes fue de 49 años, el 64% eran mujeres y el 36% eran hombres. En el 73,4% se diagnosticó onicomicosis, ya sea por examen directo positivo y cultivo positivo, o solo con el examen directo, de las cuales 89,4% eran uñas de pie y 10,6% uñas de manos. De las uñas de los pies se aisló más frecuentemente Trichophyton rubrum y en segundo lugar Fusarium spp. En uñas de manos C. albicans fue el agente etiológico más frecuente. Conclusión: En el diagnóstico de las onicomicosis se debe considerar tanto la clínica como los hallazgos de laboratorio. En la población estudiada se identificaron dermatofitos

  10. Are calcium and fiber beneficial for poorly controlled diabetic patients? ¿Son calcio y fibras beneficiosos para pacientes diabéticos mal controlados?

    Directory of Open Access Journals (Sweden)

    D. A. R. Matos

    2011-04-01

    Full Text Available No nutritional protocol for poorly controlled diabetic patients receiving well-managed drug treatment is currently available. Objective: Aims were to compare dietary consumption of calcium and fibers with lipid profile and glycosilated hemoglobin HbA1c. Methodology: This was a prospective observational study. Patients with poorly controlled diabetes were consecutively recruited. A food-frequency questionnaire and tests for lipid profile, HbA1c, and C reactive protein were collected, along with clinical and anthropometric assessment. Results: Patients (N = 114, age 65.7 ± 6.5 years, 75.4% females, BMI 29.0 ± 5.3 kg/m² were often insulin-dependent (32.5% and with systemic inflammation (C-reactive protein 4.2 ± 3.9 mg/L. Diet was energy restricted (1,365 ± 565 kcal/day and mostly adequate but with suboptimal fiber (15.4 ± 8.6 g/day and very low calcium (592.4 ± 204.4 mg/day. Calcium and fiber in the diet correlated with serum lipids, whereas fiber alone displayed a protective association regarding diabetes (HBA1c, insulin use and arterial hypertension. Conclusions: Calcium and fiber ingestion exhibited correlations with important markers of metabolic status and cardiovascular risk. Future studies should address enhancement of these ingredients by means of dietary changes and supplements.Ningún protocolo nutricional es presentemente disponible para pacientes diabéticos mal controlados recibindo terapia farmacológica bien estructurada. Objetivo: Una comparación entre consumo dietético de cálcio y fibras, y concentraciones de lípidos y hemoglobina glicosilada HbA1c fue efectuada. Metodología: Este fue un estúdio prospectivo observacional. Pacientes con diabetes mal controlada fueron consecutivamente recrutados. Las variables fueron cuestionário de frecuéncia alimentária, evaluación clínica y antropométrica, y valores séricos de lípidos, HbA1c, proteina C reactiva (PCR. Resultados: Los pacientes (N = 114, edad 65,7 ± 6,5 a

  11. Estudo comparativo não randomizado do midazolam versus thiopental em crianças com estado de mal epiléptico refratário

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    LÖHR JUNIOR ALFREDO

    2000-01-01

    Full Text Available Avaliamos o uso do midazolam em relação ao thiopental em crianças com estado de mal epiléptico refratário(EMER. Foram estudadas 50 crianças com EMER, internadas em UTI-pediátrica, composto pelos: Grupo Midazolam(A (n=24 prospectivo, e o Grupo Thiopental(B (n=26 histórico. Benzodiazepina e difenil-hidantoina e outros anticonvulsivantes foram previamente utilizadas nos dois grupos. Não havendo o controle das convulsões, no Grupo A os pacientes receberam uma dose de 200 mig/kg midazolam intravenoso em bolo, seguindo-se a infusão intravenosa contínua na razão de 0,25 a 15 mig/kg/min. No grupo B foi administrado thiopental, uma dose em bolo intravenosa de 1 mg/kg,, seguida de infusão intravenosa contínua na razão de 10-120 mig/kg/min. Em relação ao tempo de controle das crises e sua eficácia, não houve significância estatística para os dois grupos. No Grupo A houve significativamente menos complicações durante o tratamento: menos cianose (p=0,00006 e menos crianças necessitaram de ventilação assistida (p<0,00001. No Grupo A, 12,5% dos pacientes, na pós-terapia imediata, apresentaram alterações psíquicas, como agitação, confusão mental, alucinação visual.

  12. Avaliação da eficácia do artesunato associado à tetraciclina na terapêutica da malária falciparum

    Directory of Open Access Journals (Sweden)

    Villalobos Salcedo Juan Miguel

    1997-01-01

    Full Text Available Realizou-se um ensaio clínico, randomizado e controlado, comparando o artesunato com o quinino e a mefloquina, em casos de malária não grave. Foram tratados 42 pacientes em regime de internação e o seguimento durou 28 dias. Realizou-se exame de gota espessa cada 12 horas até sua negativação, hemograma e bioquímica sanguínea, pré e pós-tratamento. A média da parasitemia inicial foi 42.568 parasitas/ml. Vinte e seis pacientes foram acompanhados durante 28 dias e 16 durante menos de 28 dias. Um paciente de cada grupo apresentou R I tardia e um paciente do grupo do quinino apresentou R III. As porcentagens de cura foram 88,8%, 85,7% e 81,8% para o artesunato, a mefloquina e o quinino, respectivamente, sem mostrar diferença significativa. O tempo de desaparecimento da febre não mostrou diferença significativa entre os grupos. O grupo do artesunato teve um tempo menor de clareamento da parasitemia (37,33 ± 11,52 horas quando comparado com o quinino (65,25 ± 17,44 horas, sendo estatisticamente significativa (p = 0,0016. O grupo da mefloquina (58,9 ± 16,68 horas não mostrou diferença com os outros grupos. Não se apresentaram efeitos adversos importantes em nenhum dos esquemas usados, sendo bem tolerados pelos pacientes.

  13. Controle da malária transfusional em região endêmica e não endêmica do Brasil

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    Sáez-Alquézar Amadeo

    1998-01-01

    Full Text Available O presente trabalho teve como objetivo estabelecer critérios adequados à triagem de doadores de sangue de regiões com características epidemiológicas distintas, para malária. Foram estudados 3 locais com critérios de seleção diferentes: São Paulo, SP (sem transmissão vetorial, Belém (baixa transmissão ativa, Matupá, Belém, PA e Peixoto de Azevedo, MT (alta transmissão ativa. A pesquisa de plasmódios foi realizada por gota espessa, QBC Test® e imunofluorescência para pesquisa de antígenos, tendo sido todas as amostras negativas. Houve grande variação na positividade para anticorpos antiplasmodiais por IFI-IgG anti P. vivax e P. falciparum entre doadores aptos nos 3 locais de estudo e entre doadores aptos e inaptos em São Paulo (aptos 1,98%, inaptos 22,3%, p < 0.01 e Belém (aptos 17,2%, inaptos 58,3%, p < 0.01, o que atesta a validade da triagem clínico-epidemiológica realizada. Em Matupá e Peixoto de Azevedo não houve doadores inaptos e a positividade foi de 80,6%. Consideramos que em bancos de sangue a triagem deve seguir critérios clínico-epidemiológicos adequados à situação de cada região. Os métodos laboratoriais de triagem, devem ser para detecção de plasmódios (gota espessa/QBC Test® ou detecção de antígenos parasitários.

  14. Ajuste rápido de dosis de tapentadol en el tratamiento del dolor mal controlado Fast titration of tapentadol for the treatment of badly controlled pain

    Directory of Open Access Journals (Sweden)

    M. J. Sánchez del Águila

    2012-02-01

    Full Text Available Introducción: el tapentadol es un nuevo fármaco de acción dual MOR/NRI, que actúa a nivel central, efectivo en el tratamiento del dolor moderado e intenso, que presenta un perfil de tolerabilidad mas favorable que otros opiáceos. Esto podría permitir una titulación rápida que permita un control precoz del dolor. Material y métodos: presentamos dos casos clínicos en los que se realiza una titulación rápida de la dosis de tapentadol en pacientes hospitalizados con dolor mal controlado. Este ajuste rápido, permitió controlar el dolor, en ausencia de efectos secundarios, acortando el tiempo de estancia hospitalaria de estos pacientes. Conclusiones: el perfil favorable de efectos secundarios mostrado por el tapentadol, permite un ajuste rápido de la dosis, que consigue un control eficaz del dolor en un menor lapso de tiempo.Background: tapentadol is a new drug with a centrally acting, dual action mechanism on MOR/NRI. It is effective on moderate to severe pain and shows a favourable side effects profile in comparison to other major opiates. This could allow a fast dose titration to achieve an earlier pain control. Material and methods: we present two cases on which we have performed a fast dose titration in hospitalised patients with bad pain control. This fast titration allowed an early control of the pain, in absence of side effects, achieving a shortening in their hospital stay. Conclusions: the favourable side effects profile of tapentadol, allows a fast dose titration, achieving an efficacious pain control in a shorter time lapse.

  15. Clones de copa de seringueira resistentes ao mal-das-folhas para o cultivo na Amazônia tropical úmida

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    Larissa Alexandra Cardoso Moraes

    2013-01-01

    Full Text Available O objetivo deste trabalho foi avaliar o desempenho de 11 clones de copa de seringueira de Hevea pauciflora × H. guianensis, H. guianensis × H. pauciflora, H. pauciflora × H. rigidifolia e H. pauciflora resistentes ao fungo Microcyclus ulei, causador do mal-das-folhas, sobre o painel de CNS AM 7905 (seleção primária de H. brasiliensis, durante 14 anos nas condições edafoclimáticas da Amazônia tropical úmida. Foram avaliados: produtividade de borracha seca durante sete anos, aspectos anatômicos, características fisiológicas do látex, estado nutricional das plantas e métodos de sangria (oriental e amazônica. Os clones de copa CPAA C 01, 06 e 45 produziram, na média, mais de 1,4 t ha- 1 ano- 1 de borracha seca, seguido pelos clones CPAA C 13, 14, 15, 16 e 20, com produtividade acima de 1,0 t ha-1 ano- 1, enquanto os clones CPAA C 18, CPAA C 33 e CBA 2 registraram produtividade inferior a 0,9 t ha-1 ano- 1. A concentração de Pi e Mg no látex e os teores foliares de K e Cu estão relacionados com a produtividade dos clones CPAA C 01, 06 e 45, sendo esses fatores importantes no programa de seleção de clones de copa de seringueira. Em plantio comercial, o método da sangria oriental é mais eficiente que a amazônica.

  16. Inter-domain communication mechanisms in an ABC importer: a molecular dynamics study of the MalFGK2E complex.

    Science.gov (United States)

    Oliveira, A Sofia F; Baptista, António M; Soares, Cláudio M

    2011-08-01

    ATP-Binding Cassette transporters are ubiquitous membrane proteins that convert the energy from ATP-binding and hydrolysis into conformational changes of the transmembrane region to allow the translocation of substrates against their concentration gradient. Despite the large amount of structural and biochemical data available for this family, it is still not clear how the energy obtained from ATP hydrolysis in the ATPase domains is "transmitted" to the transmembrane domains. In this work, we focus our attention on the consequences of hydrolysis and inorganic phosphate exit in the maltose uptake system (MalFGK(2)E) from Escherichia coli. The prime goal is to identify and map the structural changes occurring during an ATP-hydrolytic cycle. For that, we use extensive molecular dynamics simulations to study three potential intermediate states (with 10 replicates each): an ATP-bound, an ADP plus inorganic phosphate-bound and an ADP-bound state. Our results show that the residues presenting major rearrangements are located in the A-loop, in the helical sub-domain, and in the "EAA motif" (especially in the "coupling helices" region). Additionally, in one of the simulations with ADP we were able to observe the opening of the NBD dimer accompanied by the dissociation of ADP from the ABC signature motif, but not from its corresponding P-loop motif. This work, together with several other MD studies, suggests a common communication mechanism both for importers and exporters, in which ATP-hydrolysis induces conformational changes in the helical sub-domain region, in turn transferred to the transmembrane domains via the "coupling helices".

  17. Inter-domain communication mechanisms in an ABC importer: a molecular dynamics study of the MalFGK2E complex.

    Directory of Open Access Journals (Sweden)

    A Sofia F Oliveira

    2011-08-01

    Full Text Available ATP-Binding Cassette transporters are ubiquitous membrane proteins that convert the energy from ATP-binding and hydrolysis into conformational changes of the transmembrane region to allow the translocation of substrates against their concentration gradient. Despite the large amount of structural and biochemical data available for this family, it is still not clear how the energy obtained from ATP hydrolysis in the ATPase domains is "transmitted" to the transmembrane domains. In this work, we focus our attention on the consequences of hydrolysis and inorganic phosphate exit in the maltose uptake system (MalFGK(2E from Escherichia coli. The prime goal is to identify and map the structural changes occurring during an ATP-hydrolytic cycle. For that, we use extensive molecular dynamics simulations to study three potential intermediate states (with 10 replicates each: an ATP-bound, an ADP plus inorganic phosphate-bound and an ADP-bound state. Our results show that the residues presenting major rearrangements are located in the A-loop, in the helical sub-domain, and in the "EAA motif" (especially in the "coupling helices" region. Additionally, in one of the simulations with ADP we were able to observe the opening of the NBD dimer accompanied by the dissociation of ADP from the ABC signature motif, but not from its corresponding P-loop motif. This work, together with several other MD studies, suggests a common communication mechanism both for importers and exporters, in which ATP-hydrolysis induces conformational changes in the helical sub-domain region, in turn transferred to the transmembrane domains via the "coupling helices".

  18. Parafusos pediculares mal posicionados pela técnica freehand: qual o real valor para o surgimento de lesões neurológicas?

    Directory of Open Access Journals (Sweden)

    Marina Hirschle Galindo

    2013-12-01

    Full Text Available OBJETIVO: Verificar a existência de lesões neurológicas nos pacientes submetidos à instrumentação com parafusos pediculares mal posicionados na região toracolombar. MÉTODOS: Estudo prospectivo com seleção randômica de 30 pacientes submetidos à instrumentação pedicular por via posterior, pela técnica freehand. Foi avaliada comparativamente, de forma cega, a adequação do posicionamento dos parafusos nas vértebras por meio de tomografias. A seguir, tentou-se correlacionar a existência de alterações neurológicas relacionadas ao posicionamento dos implantes. RESULTADOS: Observados 223 parafusos pediculares na coluna toracolombar em 30 pacientes operados no serviço por diversas doenças. Houve violação da parede do pedículo vertebral em 33% dos pacientes, sendo mais da metade com invasão da cortical medial. A piora neurológica no pós-operatório imediato ocorreu em três pacientes, entretanto apenas um parafuso precisou de reposicionamento. Todos os pacientes recuperaram a situação neurológica pré-cirúrgica. CONCLUSÕES: O índice de violação cortical com parafusos pediculares mostrou-se elevado. Contudo, nota-se que pequenas violações pediculares podem causar danos neurológicos e que, quando esses acontecem, são reversíveis se o erro for corrigido.

  19. Interpenetration of a 3D Icosahedral M@Ni12 (M=Al, Ga) Framework with Porphyrin-Reminiscent Boron Layers in MNi9 B8.

    Science.gov (United States)

    Zheng, Qiang; Wagner, Frank R; Ormeci, Alim; Prots, Yurii; Burkhardt, Ulrich; Schmidt, Marcus; Schnelle, Walter; Grin, Yuri; Leithe-Jasper, Andreas

    2015-11-01

    Two ternary borides MNi9 B8 (M=Al, Ga) were synthesized by thermal treatment of mixtures of the elements. Single-crystal X-ray diffraction data reveal AlNi9 B8 and GaNi9 B8 crystallizing in a new type of structure within the space group Cmcm and the lattice parameters a=7.0896(3) Å, b=8.1181(3) Å, c=10.6497(4) Å and a=7.0897(5) Å, b=8.1579(4) Å, c=10.6648(7) Å, respectively. The boron atoms build up two-dimensional layers, which consist of puckered [B16 ] rings with two tailing B atoms, whereas the M atoms reside in distorted vertices-condensed [Ni12 ] icosahedra, which form a three-dimensional framework interpenetrated by boron porphyrin-reminiscent layers. An unusual local arrangement resembling a giant metallo-porphyrin entity is formed by the [B16 ] rings, which, due to their large annular size of approximately 8 Å, chelate four of the twelve icosahedral Ni atoms. An analysis of the chemical bonding by means of the electron localizability approach reveals strong covalent B-B interactions and weak Ni-Ni interactions. Multi-center dative B-Ni interaction occurs between the Al-Ni framework and the boron layers. In agreement with the chemical bonding analysis and band structure calculations, AlNi9 B8 is a Pauli-paramagnetic metal. PMID:26418894

  20. Establishment of novel in vitro mouse chief cell and SPEM cultures identifies MAL2 as a marker of metaplasia in the stomach.

    Science.gov (United States)

    Weis, Victoria G; Petersen, Christine P; Mills, Jason C; Tuma, Pamela L; Whitehead, Robert H; Goldenring, James R

    2014-10-15

    Oxyntic atrophy in the stomach leads to chief cell transdifferentiation into spasmolytic polypeptide expressing metaplasia (SPEM). Investigations of preneoplastic metaplasias in the stomach are limited by the sole reliance on in vivo mouse models, owing to the lack of in vitro models for distinct normal mucosal lineages and metaplasias. Utilizing the Immortomouse, in vitro cell models of chief cells and SPEM were developed to study the characteristics of normal chief cells and metaplasia. Chief cells and SPEM cells isolated from Immortomice were cultured and characterized at both the permissive (33°C) and the nonpermissive temperature (39°C). Clones were selected on the basis of their transcriptional expression of specific stomach lineage markers (named ImChief and ImSPEM) and protein expression and growth were analyzed. The transcriptional expression profiles of ImChief and ImSPEM cells were compared further by using gene microarrays. ImChief cells transcriptionally express most chief cell markers and contain pepsinogen C and RAB3D-immunostaining vesicles. ImSPEM cells express the SPEM markers TFF2 and HE4 and constitutively secrete HE4. Whereas ImChief cells cease proliferation at the nonpermissive temperature, ImSPEM cells continue to proliferate at 39°C. Gene expression profiling of ImChief and ImSPEM revealed myelin and lymphocyte protein 2 (MAL2) as a novel marker of SPEM lineages. Our results indicate that the expression and proliferation profiles of the novel ImChief and ImSPEM cell lines resemble in vivo chief and SPEM cell lineages. These cell culture lines provide the first in vitro systems for studying the molecular mechanisms of the metaplastic transition in the stomach.

  1. Comparison of the OptiMAL rapid antigen test with field microscopy for the detection of Plasmodium vivax and P. falciparum: considerations for the application of the rapid test in Afghanistan.

    Science.gov (United States)

    Kolaczinski, J; Mohammed, N; Ali, I; Ali, M; Khan, N; Ezard, N; Rowland, M

    2004-01-01

    To establish the sensitivity and specificity of a batch of 'OptiMAL 48' rapid antigen tests procured by the World Health Organization in Afghanistan, a sample was tested, in parallel with routine, microscopical diagnosis, at basic health units (BHU) within Afghan refugee camps in Pakistan. The results of both methods of field diagnosis were compared with those of cross-checking microscopy at a reference laboratory, which were taken as the 'gold standard'. Out of 499 patients examined, 36% were diagnosed as malaria cases by field microscopy and 34% by the rapid test. For the OptiMAL 48 test, cross-checking of the corresponding smears at the reference laboratory gave a sensitivity of 79.3% and a specificity of 99.7% for Plasmodium falciparum and corresponding values of 86.1% and 98.7% for P. vivax infections. The performance of the field microscopy was better, with a sensitivity and specificity of 85.2% and 99.7% for P. falciparum, and 90.4% and 98.7% for P. vivax, respectively. These results show that the performance of OptiMAL 48 is adequate for acute- and post-emergency situations when the alternative is just clinical diagnosis. However, in the developing health system of Afghanistan, the main focus should be on the expansion of the existing network for microscopical diagnosis and quality control, to meet the needs of a stable situation. Rapid antigen tests are more suited to investigations of outbreaks in remote situations, where health services are deficient or absent. PMID:15000726

  2. Mis17 is a regulatory module of the Mis6-Mal2-Sim4 centromere complex that is required for the recruitment of CenH3/CENP-A in fission yeast.

    Directory of Open Access Journals (Sweden)

    Yoshiharu Shiroiwa

    Full Text Available BACKGROUND: The centromere is the chromosome domain on which the mitotic kinetochore forms for proper segregation. Deposition of the centromeric histone H3 (CenH3, CENP-A is vital for the formation of centromere-specific chromatin. The Mis6-Mal2-Sim4 complex of the fission yeast S. pombe is required for the recruitment of CenH3 (Cnp1, but its function remains obscure. METHODOLOGY/PRINCIPAL FINDINGS: Mass spectrometry was performed on the proteins precipitated with Mis6- and Mis17-FLAG. The results together with the previously identified Sim4- and Mal2-TAP precipitated proteins indicated that the complex contains 12 subunits, Mis6, Sim4, Mal2, Mis15, Mis17, Cnl2, Fta1-4, Fta6-7, nine of which have human centromeric protein (CENP counterparts. Domain dissection indicated that the carboxy-half of Mis17 is functional, while its amino-half is regulatory. Overproduction of the amino-half caused strong negative dominance, which led to massive chromosome missegregation and hypersensitivity to the histone deacetylase inhibitor TSA. Mis17 was hyperphosphorylated and overproduction-induced negative dominance was abolished in six kinase-deletion mutants, ssp2 (AMPK, ppk9 (AMPK, ppk15 (Yak1, ppk30 (Ark1, wis4 (Ssk2, and lsk1 (P-TEFb. CONCLUSIONS: Mis17 may be a regulatory module of the Mis6 complex. Negative dominance of the Mis17 fragment is exerted while the complex and CenH3 remain at the centromere, a result that differs from the mislocalization seen in the mis17-362 mutant. The known functions of the kinases suggest an unexpected link between Mis17 and control of the cortex actin, nutrition, and signal/transcription. Possible interpretations are discussed.

  3. Luminescent phosphors, based on rare earth substituted oxyfluorides in the A(1){sub 3-x} A(2){sub x}MO{sub 4}F family with A(1)/A(2)=Sr, Ca, Ba and M=Al, Ga

    Energy Technology Data Exchange (ETDEWEB)

    Park, Sangmoon, E-mail: spark@silla.ac.k [Department of Engineering in Energy and Applied Chemistry, Silla University, Busan 617-736 (Korea, Republic of); Vogt, Thomas [NanoCenter and Department of Chemistry and Biochemistry, University of South Carolina, Columbia 29208, SC (United States)

    2009-09-15

    A new family of UV-activated phosphors made by substituting rare-earth activators such as trivalent Eu, Tb, Tm and Er into A(1){sub 3-x}A(2){sub x}MO{sub 4}F host lattices (A(1)/A(2)=Sr, Ca, Ba; M=Al, Ga) are introduced and their activation and emission spectra as well as their CIE values reported. The Tm-substituted system can be activated using light with a wavelength of 360 nm. Relative intensities of a family of Tb-substituted green phosphors activated at 254 nm and with emissions centered near 548 nm are discussed.

  4. A retrospective analysis of real-life practice of off-label photodynamic therapy using methyl aminolevulinate (MAL-PDT) in 20 Italian dermatology departments. Part 2: oncologic and infectious indications.

    Science.gov (United States)

    Calzavara-Pinton, Pier Giacomo; Rossi, Maria Teresa; Sala, Raffaella

    2013-01-01

    Photodynamic therapy (PDT) with methyl aminolevulinate (MAL) has been suggested as a useful treatment option in a number of skin tumors, other than approved indications, and infections. However, evidence is poor because it is mainly supported by isolated case reports or small case series, often with conflicting results. To assess the effectiveness, tolerability and safety of off-label MAL-PDT in daily clinical practice in 20 Italian hospitals, a retrospective observational study of medical records of patients treated for off-label oncologic and infectious skin conditions was carried out. In all patients standard treatment options had been either ineffective, unacceptably toxic, or medically contraindicated. Clinical data from 145 patients were analyzed. Actinic cheilitis showed a complete remission (CR) in 27 out of 43 treated patients and CR was maintained at follow-up. CR was registered in 3 of 8, 5 of 8 and 10 of 17 treated patients who were affected by extra-mammary Paget's disease (EMPD), erythroplasia of Queyrat (QD), and invasive squamous cell carcinoma (SCC), respectively. Five out of 19 patients with cutaneous T cell lymphoma had a complete remission. Cutaneous B-cell lymphoma, malignant fibrous histiocytoma, mastocytosis and nevus sebaceous were not responsive. Warts were treated in 30 patients and 15 had a complete remission. However, periungueal and plantar lesions were much more responsive than flat and common lesions. Condylomata showed a CR in 2 out of 5 male patients but treatment was painful. Bowenoid papulosis showed only a partial improvement. Atypical mycobacteriosis and chronic cutaneous leishmaniasis were successfully treated. Submammary candidal intertrigo and interdigital intertrigo with Pseudomonas aeruginosa did not improve. Among off-label oncological uses of MAL-PDT, the therapy of actinic cheilitis was the most investigated and showed the best results. In addition, MAL-PDT was used successfully in the majority of patients with QD, EMPD

  5. Malária pulmonar: aspectos na tomografia computadorizada de alta resolução - relato de caso Pulmonary malaria: high-resolution computed tomography findings - a case report

    OpenAIRE

    Rosana Rodrigues; Edson Marchiori; Daniel Andrade Tinoco de Souza

    2004-01-01

    Neste trabalho é relatado o caso de paciente do sexo masculino, de 38 anos de idade, que desenvolveu quadro de malária com comprometimento pulmonar. A tomografia computadorizada de alta resolução evidenciou espessamento de septos interlobulares e de bainhas peribroncovasculares, com áreas esparsas de atenuação em vidro fosco e de consolidações, além de derrame pleural bilateral, aspectos compatíveis com edema pulmonar. O paciente recebeu tratamento específico, evoluindo bem e tendo alta 11 di...

  6. Mis17 Is a Regulatory Module of the Mis6-Mal2-Sim4 Centromere Complex That Is Required for the Recruitment of CenH3/CENP-A in Fission Yeast

    OpenAIRE

    Yoshiharu Shiroiwa; Takeshi Hayashi; Yohta Fujita; Alejandro Villar-Briones; Nobuyasu Ikai; Kojiro Takeda; Masahiro Ebe; Mitsuhiro Yanagida

    2011-01-01

    BACKGROUND: The centromere is the chromosome domain on which the mitotic kinetochore forms for proper segregation. Deposition of the centromeric histone H3 (CenH3, CENP-A) is vital for the formation of centromere-specific chromatin. The Mis6-Mal2-Sim4 complex of the fission yeast S. pombe is required for the recruitment of CenH3 (Cnp1), but its function remains obscure. METHODOLOGY/PRINCIPAL FINDINGS: Mass spectrometry was performed on the proteins precipitated with Mis6- and Mis17-FLAG. The ...

  7. Intervención familiar para el manejo psicológico en pacientes oncológicos con mal pronóstico en el hospital de la misericordia

    OpenAIRE

    Martha Restrepo Forero; Ana Carolina Rodríguez Ibarra; Rubi Yasmín Ruiz Suárez

    2008-01-01

    Se diseñó un programa fundamentado en el modelo cognitivo conductual de Inoculación de Estrés e intervención en duelo anticipatorio basado en cuatro tareas. El programa fue aplicado a tres pacientes con mal pronóstico del Servicio de Oncohematología del Hospital de la Misericordia y a sus familias. Por medio de estudio de caso, se describieron factores de riesgo y de protección así como respuestas frente a dicha intervención. El análisis cualitativo de casos arrojó la descripción de respuesta...

  8. Propiedades interfaciales del surfactante pdms-peganhídrido maléico-ácido fumárico (pdms-peg-am-af) en solución acuosa

    OpenAIRE

    Johana Rodríguez; Edgardo Meza Fuentes; Maria Cecilia Azevedo Espiridiao

    2011-01-01

    En este estudio se determinaron las propiedadesinterfaciales en solución acuosadel surfactante del tipo PDMS-éster quecontiene polidimetilsiloxano (PDMS),polietilenglicol (PEG), anhídrido maléicoy ácido fumárico. Para el estudio delas propiedades interfaciales se emplearonlas técnicas tensiometría y espectroscopiaen la región del UV-Vis. En soluciónacuosa este surfactante mostró uncomportamiento complejo, que es dependientede la concentración. En este surfactantese observó un cambio brusco en...

  9. Spoločenstvá suchozemských mäkkýšov severnej časti Devínskej Kobyly (Malé Karpaty)

    OpenAIRE

    Jozef Šteffek

    2005-01-01

    Present paper is focused on two topics. First topic is focused on evaluation of mollusc assemblages of northern part of the Devínska Kobyla hill (Malé Karpaty Mts.). The second topic was evaluation of all published data on molluscs of this area. The research was conducted during vegetation period of the year 1978. From 9 types of biotopes altogether 47 quantitative samples were sampled. The assemblages were evaluated on the base of constancy and dominance of the species. Altogether 7913 mollu...

  10. FACTORES ASOCIADOS A MAL ESTADO DE SALUD PERCIBIDO O A MALA CALIDAD DE VIDA EN PERSONAS MAYORES DE 65 AÑOS

    Directory of Open Access Journals (Sweden)

    Mercedes Azpiazu Garrido

    2002-01-01

    Full Text Available Fundamento: Hoy en d a, en los pa ses desarrollados, llegar a una edad avanzada ha dejado de ser algo excepcional, sin embargo muchas personas no logran envejecer con una buena calidad de vida. El presente trabajo tiene como objetivos, contribuir a un mejor conocimiento de los principales factores que influyen en la calidad de vida y la percepci n de la salud de los mayores de 65 a os, as como determinar qu ventajas y desventajas presenta cada uno de los tres instrumentos de medida de la salud y la calidad de vida frente a los otros dos instrumentos utilizados. M todos: A partir de 911 encuestas a personas mayores de 65 a os no institucionalizadas, realizadas a domicilio, se hizo un an lisis multivariante mediante regresi n log stica, poniendo en relaci n los resultados obtenidos en el Perfil de Salud de Nottingham (PSN, el Euroqol y el EAS con las caracter siticas sociodemogr ficas, el nivel de recursos econ micos, el grado de apoyo sociofamiliar, el estado de salud f sica y mental y la capacidad funcional. Resultados: Los principales factores que se asocian con la percepci n de un mal estado de salud y mala calidad de vida en el Euroqol y el PSN son los trastornos de ansiedad (Odd Ratios entre 1,8 (IC:1,2-2,8 para movilidad y 7,9 (IC:4,5-13,9 para Perfil 11111, trastornos depresivos (OR:1,8 (IC:1,3-2,6 para dolor/malestar ?3,3 (IC:2,1-5,1 para aislamiento social, falta de ejercicio (OR:1,4 (IC:1-2,1 para ansiedad/depresi n ?3,9 (IC:2,5-6,2 para actividades cotidianas, dependencia para las actividades b sicas de la vida diaria (OR:0,5 (IC:0,3-0,9 para reacci n emocional ?4,8 (IC:3-7,6 para actividades cotidianas y dependencia para las actividades instrumentales de la vida diaria (OR:1,5 (IC:1,1-2,1 para Escala Visual Anal gicac < 70 ? 7,1 (IC:2,9-17,2 para cuidado personal. Conclusiones: La salud mental y la capacidad funcional son los factores que m s influyen en la percepci n del estado de salud y la calidad de vida de las personas mayores

  11. Faktoring – jedna z hlavních forem financování malých a středních podniků

    Directory of Open Access Journals (Sweden)

    Müllerová Libuše

    2009-12-01

    Full Text Available Faktoring představuje službu, kterou poskytují specializované faktoringové společnosti svým klientům v souvislosti s postoupením nebo se správou pohledávek. Ve své podstatě se jedná o určitý způsob úvěrování, využívaný zejména malými a středními podniky. V praxi existuje několik forem faktoringu v závislosti na tom, do jaké míry přechází na faktora vlastnictví pohledávek a rizika jejich nesplacení. Podle toho se pak faktoringové transakce promítají do účetnictví faktora i klienta. Vzhledem k tomu, že tato služba ani její formy není upravená žádným právním předpisem, postupují faktoringové společnosti často tak, že podmínky ve smlouvách – z důvodu daňových – často zakrývají svojí formou skutečný stav. Uvedený příspěvek základní formy faktoringu vymezuje, popisuje jejich správné účtování včetně daňových dopadů. Factoring is a service, which is offered by specialized factoring agencies to their clients in case of transfer (sale or governance of receivables. In fact, it represents a specific mode of crediting which is mostly preferred by small and medium enterprises. In practices of factoring several forms are differentiated depending on scale of property and risk transfer to the factor. According to these circumstances the factoring transactions are recognized by the factor and the client. The factoring services are not so far regulated by any legal provision. For this reason factoring agencies are proceeding in such a way, that contract conditions – because of tax considerations – hide by their form the substance. The paper describes the factoring forms and interprets their correct recognition on accounting, including tax consequences.

  12. Synthesis and characterization of aluminum and gallium complexes of heterocyclic thiosemicarbazones. crystal structures of Me2M[SC4H3CHNNC(S)SCH3] (M=Al, Ga)

    International Nuclear Information System (INIS)

    The synthesis and characterization of the monomeric group 13 heterocyclic thiosemicarbazone complexes Me2M[SC4H3CHNNC(S)SCH3] (M=Al (2), Ga (3)) are described. Compounds 2-3 were prepared using MMe3 (M=Al, Ga) in toluene with 2-thiophenecarboxaldehyde-S-methyldithiocarbazate under anaerobic conditions. These complexes have been characterized by 1H NMR, 13C NMR, elemental analyses, and single-crystal X-ray diffraction. 2 crystallizes in the monoclinic space group P21/c with unit cell parameters a=10.2930(5) A, b=18.564 (1) A, c=7.3812(6) A, V=1347.9(2) A3, Dcalc=1.342 gcm-3 for Z=4, 9281 reflections with Ibca with unit cell parameters a=13.340(3) A, b=19.9070(5) A, c=11.3690(2) A, V=2673.88(9) A3, Dcalc=1.511 gcm-3 for Z=8, 17004 reflections with I>3σ(I), R1=0.0480 and wR2=0.0524. Compound 3 is a monomeric gallium compound with a weak interaction between the pendant thiophene and the gallium center

  13. Prostorové rozhraní informačního systému malé obce řešené v Open Source Software

    Directory of Open Access Journals (Sweden)

    Karel Jedlička

    2006-12-01

    Full Text Available Příspěvek si klade za cíl představit možnosti open source software pro implementaci prostorového rozhraní informačního systému malé obce.Zabývá se návrhem projektu po jednotlivých částech: identifikace požadavků zastupitelského úřadu (uživatele systému, popis obecné architektury systému a volba vhodných (nekomerčních technologií pro jeho implementaci. Součástí projektu je i popis vyvinuté technologie pro import nejdůležitějších datových vrstev (informací o vlastnictví do systému.Článek je doplněn výčtem využitelných datových zdrojů pro informační systém malé obce v České republice.

  14. Associação de metemoglobinemia e deficiência de glicose-6-fosfato desidrogenase em pacientes com malária tratados com primaquina Association of methemoglobinemia and glucose-6-phosphate dehydrogenase deficiency in malaria patients treated with primaquine

    OpenAIRE

    Marli Stela Santana; Marcos Antonio Ferreira da Rocha; Ana Ruth Lima Arcanjo; José Felipe Jardim Sardinha; Wilson Duarte Alecrim; Maria das Graças Costa Alecrim

    2007-01-01

    Este estudo teve como objetivo verificar a ocorrência de metemoglobinemia em indivíduos deficientes da glicose-6-fosfato desidrogenase durante o tratamento da infecção malárica com primaquina. Foram selecionados pacientes com diagnóstico para malária por Plasmodium vivax ou mista V+F (Plasmodium vivax + Plasmodium falciparum), Grupo 1: com 74 indivíduos com diagnóstico clínico de metemoglobinemia e Grupo 2: 161 indivíduos sem diagnóstico clínico de metemoglobinemia. Quanto à deficiência da G6...

  15. Factores asociados a mal estado de salud percibido o a mala calidad de vida en personas mayores de 65 años

    Directory of Open Access Journals (Sweden)

    Azpiazu Garrido Mercedes

    2002-01-01

    Full Text Available Fundamento: Hoy en día, en los países desarrollados, llegar a una edad avanzada ha dejado de ser algo excepcional, sin embargo muchas personas no logran envejecer con una buena calidad de vida. El presente trabajo tiene como objetivos, contribuir a un mejor conocimiento de los principales factores que influyen en la calidad de vida y la percepción de la salud de los mayores de 65 años, así como determinar qué ventajas y desventajas presenta cada uno de los tres instrumentos de medida de la salud y la calidad de vida frente a los otros dos instrumentos utilizados. Métodos: A partir de 911 encuestas a personas mayores de 65 años no institucionalizadas, realizadas a domicilio, se hizo un análisis multivariante mediante regresión logística, poniendo en relación los resultados obtenidos en el Perfil de Salud de Nottingham (PSN, el Euroqol y el EAS con las caracterísiticas sociodemográficas, el nivel de recursos económicos, el grado de apoyo sociofamiliar, el estado de salud física y mental y la capacidad funcional. Resultados: Los principales factores que se asocian con la percepción de un mal estado de salud y mala calidad de vida en el Euroqol y el PSN son los trastornos de ansiedad (Odd Ratios entre 1,8(IC:1,2-2,8 para movilidad y 7,9(IC:4,5-13,9 para Perfil ≠11111, trastornos depresivos (OR:1,8(IC:1,3-2,6 para dolor/malestar- 3,3(IC:2,1-5,1 para aislamiento social, falta de ejercicio (OR:1,4 (IC:1-2,1 para ansiedad/depresión -3,9(IC:2,5-6,2 para actividades cotidianas, dependencia para las actividades básicas de la vida diaria (OR:0,5(IC:0,3-0,9 para reacción emocional - 4,8(IC:3-7,6 para actividades cotidianas y dependencia para las actividades instrumentales de la vida diaria (OR:1,5(IC:1,1-2,1 para Escala Visual Analógicac<70 - 7,1(IC:2,9-17,2 para cuidado personal. Conclusiones: La salud mental y la capacidad funcional son los factores que más influyen en la percepción del estado de salud y la calidad de vida de las

  16. Ejercicio y la detección del mal agudo de montaña grave Exercise and the detection of severe acute mountain sickness

    Directory of Open Access Journals (Sweden)

    Adrián Garófoli

    2010-02-01

    Full Text Available El mal agudo de montaña (MAM es un conjunto de síntomas inespecíficos padecidos por sujetos que ascienden rápidamente desde baja a alta altura sin adecuada aclimatación. Usualmente es autolimitado, pero las formas graves (edema pulmonar y cerebral pueden causar la muerte. La hipoxemia exagerada en reposo está relacionada con el desarrollo de MAM pero su valor predictivo es limitado. Dado que el ejercicio en altura se acompaña de mayor hipoxemia y síntomas, postulamos el valor predictivo de un simple test de ejercicio para pronosticar MAM grave. Se estudió el valor predictivo de la saturación de oxígeno en reposo y ejercicio submáximo a 2.700 m y 4 300 m en 63 sujetos que ascendían al cerro Aconcagua (6 962 m. Se consideró desaturación de oxígeno con ejercicio a una disminución = 5% respecto al reposo. Se utilizó la escala de Lake-Louise para establecer la presencia de MAM grave. Seis sujetos presentaron MAM grave (9.5% y requirieron evacuación. La saturación de oxígeno en reposo a 2.700 m no fue significativa para clasificar sujetos que luego desarrollaron MAM grave. Por el contrario, la asociación de desaturación durante el ejercicio a 2.700 m más la saturación inapropiada en reposo a 4.300 m fue significativa para clasificar a los sujetos que desarrollaron MAM grave con un valor predictivo positivo de 80% y un valor predictivo negativo del 97%. Nuestros resultados son relevantes para el montañismo y sugieren la adición de un simple test de ejercicio en la predicción del MAM grave.Acute mountain sickness (AMS is a group of non-specific symptoms, seen in subjects that ascend from low to high altitude too quickly, without allowing sufficient time to acclimatize. Usually it is self-limiting, but the severe forms (pulmonary and cerebral edema can be fatal. Exaggerated hypoxemia at rest is related to later development of AMS but its predictive value is limited. Since exercise at altitude induces greater hypoxemia and

  17. Fertilizantes e espaçamento entre plantas na produtividade da couve-da-Malásia Fertilizers and spacing between plants in the yield of Malaysian cabbage

    Directory of Open Access Journals (Sweden)

    Wanessa Resende Ferreira

    2002-12-01

    Full Text Available As brássicas têm sido objeto constante de pesquisa devido à sua importância na alimentação humana, seja pela quantidade consumida, pelo alto valor nutricional ou por sua elevada produtividade. Brassica chinensis var. parachinensis foi introduzida no Brasil, Uberlândia, em 1992, destacando-se em relação a outras brássicas por seu alto teor de vitaminas A e C, cálcio e ferro, estando pronta para consumo em aproximadamente 30 dias. A produtividade biológica e agronômica dessa variedade foi analisada utilizando-se três tipos de fertilizantes e três espaçamentos entre plantas, visando subsidiar sua produção em escala comercial. A área foliar, massa da matéria seca e taxa de crescimento absoluto foram significativamente maiores com adubação mineral em relação à adubação orgânica. Os maiores valores referentes à taxa de crescimento relativo e taxa assimilatória líquida foram registrados em plantas mantidas nos maiores espaçamentos (30x20 e 30x30 cm. A maior produtividade agronômica foi alcançada no menor espaçamento (30x10 cm, com adubação mineral, sendo registrados 21,5 t ha-1, valor muito próximo ao registrado na Malásia e China onde essa hortaliça é cultivada em larga escala.Brassica crops have been widely studied due to their importance as food for human consumption, especially in relation to their nutritional value. Both yield and consumption are high. Brassica chinensis var. parachinensis was introduced in Brazil, in Uberlândia, in 1992, surpassing other Brassica due to its high content of vitamins A and C, calcium and iron, and being ready for consumption in about 30 days. The biological and agronomic yield of this variety was analyzed under three kinds of fertilizers and three spacings between plants with a view to its production on a commercial scale. The leaf area, dry matter mass, and absolute growth rate were higher with mineral than organic fertilizer. High values for relative growth rate and net

  18. Genesis of the Assif El Mal Zn-Pb (Cu, Ag) vein deposit. An extension-related Mesozoic vein system in the High Atlas of Morocco. Structural, mineralogical, and geochemical evidence

    Science.gov (United States)

    Bouabdellah, M.; Beaudoin, G.; Leach, D.L.; Grandia, F.; Cardellach, E.

    2009-01-01

    The Assif El Mal Zn-Pb (Cu-Ag) vein system, located in the northern flank of the High Atlas of Marrakech (Morocco), is hosted in a Cambro-Ordovician volcaniclastic and metasedimentary sequence composed of graywacke, siltstone, pelite, and shale interlayered with minor tuff and mudstone. Intrusion of synorogenic to postorogenic Late Hercynian peraluminous granitoids has contact metamorphosed the host rocks giving rise to a metamorphic assemblage of quartz, plagioclase, biotite, muscovite, chlorite, amphibole, chloritoid, and garnet. The Assif El Mal Zn-Pb (Cu-Ag) mineralization forms subvertical veins with ribbon, fault breccia, cockade, comb, and crack and seal textures. Two-phase liquid-vapor fluid inclusions that were trapped during several stages occur in quartz and sphalerite. Primary inclusion fluids exhibit Th mean values ranging from 104??C to 198??C. Final ice-melting temperatures range from -8.1??C to -12.8??C, corresponding to salinities of ???15 wt.% NaCl equiv. Halogen data suggest that the salinity of the ore fluids was largely due to evaporation of seawater. Late secondary fluid inclusions have either Ca-rich, saline (26 wt.% NaCl equiv.), or very dilute (3.5 wt.% NaCl equiv.) compositions and homogenization temperatures ranging from 75??C to 150??C. The ??18O and ??D fluid values suggest an isotopically heterogeneous fluid source involving mixing between connate seawater and black-shale-derived organic waters. Low ??13CVPDB values ranging from -7.5??? to -7.7??? indicate a homogeneous carbon source, possibly organic matter disseminated in black shale hosting the Zn-Pb (Cu-Ag) veins. The calculated ??34SH2S values for reduced sulfur (22.5??? to 24.3???) are most likely from reduction of SO42- in trapped seawater sulfate or evaporite in the host rocks. Reduction of sulfate probably occurred through thermochemical sulfate reduction in which organic matter was oxidized to produce CO2 which ultimately led to precipitation of saddle dolomite with

  19. Malária em grávidas de uma maternidade pública de Rio Branco (Acre, Brasil Malaria in pregnant women of a public maternity of Rio Branco (Acre State, Brazil

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    Regina Jarude

    2003-04-01

    Full Text Available OBJETIVO: descrever a freqüência dos achados clínico-laboratoriais em grávidas portadoras de malária. MÉTODOS: foi realizado estudo descritivo, série de casos, de 445 grávidas da Maternidade e Clínica de Mulheres Bárbara Heliodora (Rio Branco, Acre, do período de janeiro de 1996 a dezembro de 2001, com diagnóstico parasitológico de malária. Foram revistos os prontuários do período e selecionados os casos portadores de malária. RESULTADOS: no total de pacientes (n=33.420 internadas no período, estavam incluídas 445 (1,4% grávidas. Entre essas, a freqüência da infecção por Plasmodium vivax foi de 52,8% (n=235, por P. falciparum, de 43,8% (n=195, e 3,4% (n=15 por ambos os plasmódios. As alterações clínico-laboratoriais mais freqüentes (pPURPOSE: to describe the frequency of clinical and laboratorial findings in pregnant women with malaria. METHODS: a descriptive study was performed including 445 pregnant women with a positive diagnosis of malaria of the Maternity and women's Clinic Bárbara Heliodora (Rio Branco, Acre State, from January 1996 to December 2001. These cases were reviewed and the pregant women with malaria were selected. RESULTS: a total of 33,420 patients were hospitalized in that period. Of these, 445 pregnant women (1.4% were included. Among these, the frequency of the infection with Plasmodium vivax was 52.8% (n=235, with P. falciparum, 43.8% (n=195, and 3.4% (n=15 with both plasmodia. The most frequent clinical and laboratorial alterations (p<0.05 were observed in the patients with P. falciparum: pale mucosa, jaundice hemoglobin and hematocrit decrease, hypoglycemia and increase in serum aminotransferase, urea, creatinine and in bilirubin levels. Only one patient (1/445, a pregnant woman infected with P. falciparum died. Abortions, premature birth and low birth weight were detected in 1.3, 1.1 and 1.1% of the cases, respectively. CONCLUSIONS: these findings reflect the repercussion of malaria during

  20. Malaria diagnosis and treatment under the strategy of the integrated management of childhood illness (IMCI): relevance of laboratory support from the rapid immunochromatographic tests of ICT Malaria P.f/P.v and OptiMal

    DEFF Research Database (Denmark)

    Tarimo, D S; Minjas, J N; Bygbjerg, I C

    2001-01-01

    The algorithm developed for the integrated management of childhood illness (IMCI) provides guidelines for the treatment of paediatric malaria. In areas where malaria is endemic, for example, the IMCI strategy may indicate that children who present with fever, a recent history of fever and/or pallor...... and by using two rapid immunochromatographic tests (RIT) for the diagnosis of malaria (ICT Malaria P.f/P.v and OptiMal. At the time they were tested, each of these children had been targeted for antimalarial treatment (following the IMCI strategy) because of fever and/or pallor. Only 70% of the 395 children...... should receive antimalarial chemotherapy. In many holo-endemic areas, it is unclear whether laboratory tests to confirm that such signs are the result of malaria would be very relevant or useful. Children from a holo-endemic region of Tanzania were therefore checked for malarial parasites by microscopy...

  1. Entre recueil et intertextes : le poème.Autour de l’insertion de « Sonnet d’automne »dans Les Fleurs du Mal de 1861

    OpenAIRE

    Adam, Jean-Michel; Heidmann, Ute

    2008-01-01

    Cet article aborde un point négligé par la théorie du texte : la relation entre poème et recueil. À ces relations entre textes proches, nous ajoutons l'examen d'une intertextualité déclenchée par l'arrivée, en 1861, de « Sonnet d'automne » dans le recueil des Fleurs du Mal. La découverte d'une intertextualité avec le Faust de Goethe, médiatisée par la traduction de Nerval, a été rendue possible par la collaboration d'une comparatiste et d'un linguiste. L'extension du champ de l'analyse de dis...

  2. Vacinas em desenvolvimento: estreptococo do grupo B, herpes-zóster, HIV, malária e dengue Vaccines under development: group B streptococcus, herpes-zoster, HIV, malaria and dengue

    OpenAIRE

    Luiz Jacintho da Silva; Rosana Richtmann

    2006-01-01

    OBJETIVOS: As vacinas contra o estreptococo B, o herpes-zóster, o HIV, a malária e a dengue, selecionadas por critérios de comercialização iminente ou devido a problemas específicos para sua obtenção, foram objeto de uma revisão sobre o estado atual do seu desenvolvimento. FONTE DOS DADOS:Foi realizada revisão da literatura através da MEDLINE no período de 1996 a 2006, sobre a epidemiologia e imunologia das doenças, analisando tanto os maiores problemas para a obtenção de uma vacina como o es...

  3. Estudi de les diferències psicopatològiques en pacients amb mal de cap crònic, episòdic i control. Relació amb la resposta al tractament

    OpenAIRE

    Sala Matavera, Isabel

    2010-01-01

    La cefalea o mal de cap és un dels motius de consulta més freqüents als serveis de neurologia i molt prevalent a la població general. Sovint, el maneig és difícil perquè a vegades poden coexistir més d’un tipus de cefalea, no es posa suficient atenció a la comorbilitat (psicopatologia) o a altres factors que poden empitjorar la progressió de la cefalea com per exemple l’abús farmacològic. Aquest treball té per objectius (1) comparar els perfils psicopatològics de pacients amb cefalea cr...

  4. La quête de la « Terre sans mal » chez les peuples traditionnels : l’exemple des Tupi-Guarani (Amérique du Sud)

    OpenAIRE

    Navet, Eric

    2005-01-01

    Le chaman incarne au mieux les valeurs, exprimées dans le mythe, d’un mode d’être, de penser et d’agir qui vise à préserver un monde fait d’« ordre, d’harmonie, et de beauté » – selon les Indiens Ojibwé des Grands Lacs – qui nous rapproche du premier état de la Création que les Tupi-Guarani appellent la « Terre sans mal ». Comme le rêve, l’usage de psychotropes parfois réservés aux seuls chamans (champignons hallucinogènes, takweni...), ou d’un usage collectif (bière de manioc, ayahuasca, pey...

  5. Associations between chewing lice (Insecta, Phthiraptera and albatrosses and petrels (Aves, Procellariiformes collected in Brazil Associações entre malófagos (Insecta, Phthiraptera e albatrozes e petréis (Aves, Procellariiformes capturados no Brasil

    Directory of Open Access Journals (Sweden)

    Michel P. Valim

    2006-12-01

    Full Text Available Chewing lice were searched on 197 skins of 28 species of procellariiform birds collected in Brazil. A total of 38 species of lice were found on 112 skins belonging to 22 bird species. The lice were slide-mounted and identified. A list of lice species found and their host species is given and some host-louse associations are discussed under an evolutionary perspective.Malófagos foram procurados em 197 peles de 28 espécies de aves Procellariiformes capturadas no Brasil. Um total de 38 espécies de piolhos foram encontradas em 112 peles pertencentes a 22 espécies de aves. Os piolhos foram montados em lâminas e identificados. Uma lista com as espécies de piolhos encontradas e seus hospedeiros é dada, além de algumas associações entre os piolhos e as aves serem discutidas sob uma perspectiva evolutiva.

  6. Synthesis and characterization of aluminum and gallium complexes of heterocyclic thiosemicarbazones. crystal structures of Me{sub 2}M[SC{sub 4}H{sub 3}CHNNC(S)SCH{sub 3}] (M=Al, Ga)

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Young Jin; Yoo, Byung Woo; Kang, Sang Ook; Ko, Jae Jung [Korea Univ., Chochiwon (Korea, Republic of); Kang, Seung Joo [Korea National University of Education, Chongwon (Korea, Republic of)

    1998-01-01

    The synthesis and characterization of the monomeric group 13 heterocyclic thiosemicarbazone complexes Me{sub 2}M[SC{sub 4}H{sub 3}CHNNC(S)SCH{sub 3}] (M=Al (2), Ga (3)) are described. Compounds 2-3 were prepared using MMe{sub 3} (M=Al, Ga) in toluene with 2-thiophenecarboxaldehyde-S-methyldithiocarbazate under anaerobic conditions. These complexes have been characterized by {sup 1}H NMR, {sup 13}C NMR, elemental analyses, and single-crystal X-ray diffraction. 2 crystallizes in the monoclinic space group P2{sub 1}/c with unit cell parameters a=10.2930(5) A, b=18.564 (1) A, c=7.3812(6) A, V=1347.9(2) A{sup 3}, D{sub calc}=1.342 gcm{sup -3} for Z=4, 9281 reflections with I<3{sigma} (I), R1=0.0500 and wR2=0.0526. 3 crystallizes in the orthorhombic space group P{sub bca} with unit cell parameters a=13.340(3) A, b=19.9070(5) A, c=11.3690(2) A, V=2673.88(9) A{sup 3}, D{sub calc}=1.511 gcm{sup -3} for Z=8, 17004 reflections with I>3{sigma}(I), R1=0.0480 and wR2=0.0524. Compound 3 is a monomeric gallium compound with a weak interaction between the pendant thiophene and the gallium center.

  7. Performance of an immunochromatography test for vivax malaria in the Amazon region, Brazil Desempenho de um teste de imunocromatografia para malária por P. vivax na Amazônia

    Directory of Open Access Journals (Sweden)

    Alberto Ferreira Figueiredo Filho

    2003-06-01

    Full Text Available The study was carried out to evaluate the diagnostic performance of the ICT malaria Pf/PvTM test for vivax malaria diagnosis in Belém, Amazon region, Brazil. The results of blood malaria parasites examination using an immunochromatography test were compared with thick blood film (TBF examination. It was also evaluated the performance of this test storaged at three different temperatures (25°C, 30°C, and 37°C for 24 hours before use. Overall sensitivity of ICT Pf/PvTM was 61.8% with a specificity of 100%, positive and negative predictive value of 100% and 71.8%, respectively and accuracy of 80.6%. The test sensitivity was independent of the parasite density. This test needs to be further reviewed in order to have better performance for P. vivax malaria diagnosis.Avaliação do teste ICT malaria Pf/PvTM para o diagnóstico da malária por P. vivax em Belém, Estado do Pará. Foram comparados os resultados do teste imunocromatográfico com a gota espessa (GE e avaliados o comportamento desse teste, estocado a três temperaturas distintas (25(0C/ 30(0C/ 37(0C, 24 horas antes de seu uso. A sensibilidade do ICT malaria Pf/PvTM foi de 61,8% com especificidade de 100%, valores preditivo positivo e negativo de 100% e 71,8%, respectivamente, e acurácia de 80,67%. A sensibilidade desse teste foi independente da densidade parasitária. Este teste necessita de reavaliação para melhorar o seu comportamento no diagnóstico da malária por P. vivax.

  8. EFEITOS DE ALGUMAS DROGAS SISTÊMICAS NO CONTROLE PREVENTIVO DO MAL DO PANAMÁ (Fusarim oxysporum f. sp. Cubense (Ef. Sn. & H. DA BANANEIRA (Musa sapientum L. EFFECT OF SOME SYSTEMIC DRUGS IN THE PREVENTIVE CONTROL OF THE MAL-DO-PANAMÁ (Fusarium oxysporum f.sp. cubense (EF. SN. & H. OF THE BANANA TREE (Musa sapientum L.

    Directory of Open Access Journals (Sweden)

    Ildeu Matias do Nascimento

    2007-09-01

    Full Text Available

    Com o objetivo de estudar o efeito de algumas drogas sistêmicas sobre o fungo Fusarium oxysporim f. sp. cubense (Ef. Sn. & H. em tecido de rizoma de bananeira do cultivar Maçã (Musa sapientum L. foi montado um experimento em solo sob cerrado, anteriormente coberto por vegetação natural. Testou-se o efeito do Benlate (benomyl e do Plantvax (oxamyl, ambos nas doses de 0,1, 0,2 e 0,5%, do Mycostatin (nistatina nas doses de 0,02, 0,05 e 0,1% e da combinação Mycostatin + Neantina solúvel (cloreto de metoxi-etil mercúrio 3,7% nas dosagens de 0,02 + 0,15%, 0,05 + 0,3% e 0,1 + 0,5% em banho de imersão dos rizomas Infectados por um período de 10 minutos. Foram usados rizomas com infecção natural pelo patógeno. O delineamento experimental usado foi a casualização completa, com 26 tratamentos e 4 repetições. Cada parcela foi constituída de 4 plantas (covas. Os resultados observados em fevereiro de 1974, revelaram a incidência do ‘Mal do Panamá' indiscriminadamente sobre plantas de todos os tratamentos, demonstrando portanto que nenhum deles foi suficientemente eficaz para erradicar o patógeno estabelecido no tecido do rizoma. Sugeriu-se que a falta de absorção, devida à mutilação de raízes, e a precária penetração dos fungicidas do rizoma, tenham sido responsáveis pelos resultados de insucesso no controle da enfermidade. Concluiu-se que, nas condições em que foram conduzidas essas experiências, e com essa metodologia de aplicação do princípio ativo do fungicida e preparo do rizoma, o controle dessa doença não é possível, nem viável. São sugeridas modificações de procedimento em experiências futuras.

    With the objective of studying the effect of some systemic drugs on the fungus, Fusarium oxysporim f. sp. cubense (Ef. Sn. & H. , which attacks the rootstalk

  9. The monitoring of hematopoietic stem cell transplant donors and recipients from endemic areas for malaria Monitoramento de doadores e receptores provenientes de áreas endêmicas para malária em transplante de células-tronco hematopoiéticas

    Directory of Open Access Journals (Sweden)

    Juliana Inoue

    2010-10-01

    Full Text Available Malaria is an unusual complication after hematopoietic stem cell transplantation in non-endemic countries. However, transplant candidates, recipients and donors living in endemic regions frequently report previous episodes of malaria. This fact could represent an important risk for immunosuppressed recipients that could develop severe malaria cases. We report a case of hematopoietic stem cell transplant (HSCT in which the donor had a history of previous malaria, and close monitoring was performed before and after procedure by parasitological and molecular tests. The donor presented Plasmodium vivax in thick blood smears one month after transplant and was treated according to Brazilian Health Ministry guidelines. The polymerase chain reaction (PCR was able to detect malaria infection in the donor one week earlier than thick blood film. Even without positive results, the recipient was pre-emptively treated with chloroquine in order to prevent the disease. We highlight the importance of monitoring recipients and donors in transplant procedures with the aim of reducing the risk of malaria transmission.A malária é complicação incomum após o transplante de células-tronco hematopoiéticas em países endêmicos. No entanto, candidatos a transplantes, receptores e doadores que vivem em regiões endêmicas frequentemente relatam episódios anteriores de malária. Este fato pode representar um risco importante para receptores imunossuprimidos, que podem desenvolver casos de malária grave. Relatamos um caso de transplante de células-tronco hematopoiéticas (TCTH em que o doador teve história de malária anterior e um monitoramento por meio de exames parasitológicos e moleculares foi realizado antes e após o procedimento. O doador apresentou Plasmodium vivax na gota espessa um mês após o transplante e foi tratado de acordo com as orientações do Ministério da Saúde brasileiro. A reação em cadeia da polimerase (PCR foi capaz de detectar a

  10. O Enigma do Mal: uma leitura do 'De casu diaboli'de Santo Anselmo (The enigma of evil: a reading of St. Anselm’s De casu diaboli - DOI: 10.5752/P.2175-5841.2013v11n32p1551

    Directory of Open Access Journals (Sweden)

    Manoel Luís Cardoso Vasconcellos

    2013-12-01

    Full Text Available O presente artigo quer investigar o problema do mal na perspectiva de Santo Anselmo, tomando como ponto de partida sua obra De casu diaboli, onde o tema é abordado, a partir da íntima ligação entre mal e pecado. Ao enfocar o mal na perspectiva da queda diabólica, o Doutor Magnífico intenta mostrar a conexão entre vontade, liberdade e justiça. Sua preocupação é investigar o significado moral da má escolha, realizada por uma criatura racional e puramente espiritual, feita boa e para ser boa. O pecado, consoante o autor, não está em almejar a felicidade, pois tal desejo é dádiva divina; o mal praticado pelo anjo está, precisamente, em querer a felicidade fora da justiça, isto é, ao querer ser feliz, ele foi de encontro ao que ele deveria ser: quis ser semelhante a Deus, extrapolando a sua própria natureza, pois ele desejou algo que, enquanto criatura, não caberia a ele almejar. Este é o ponto de partida para analisar o mal e sua mais dramática consequência, o sofrimento. Palavras-chave: Mal. Vontade. Justiça. Anselmo.   Abstract This article aims to investigate the problem of evil in Saint Anselm, especially in his treatise De casu diaboli. He approaches this issue from the close connection between evil and sin. Upon analyzing evil from the diabolic fall perspective, Dr. Magnificent tries to establish a connection between will, freedom and justice. This text investigates the moral meaning of misconduct, carried out by a rational and purely spiritual creature that was created good and meant to be good. Seeking for happiness is not itself a sin, according to the author, for such a wish is a gift from God. The evil done by the angel lies in the act of wanting happiness without justice, that is, on wanting to be happy, the angel contradicted what he was supposed to be: he wanted to be like God, transcending his own nature, as he wished for something that, as a creature, he was not fit to wish for. This is the starting point to

  11. Associação de eventos de vida produtores de estresse e mal-estar psicológico: um estudo de base populacional Association of stressful life events and psychological distress: a community-based study

    Directory of Open Access Journals (Sweden)

    Felipe Sparrenberger

    2004-02-01

    Full Text Available Foi realizado, em 1999, estudo transversal para investigar a associação entre determinados eventos produtores de estresse e a sensação de mal-estar psicológico. A Escala de Faces foi usada para medir o desfecho. A ocorrência de morte e doença em familiar, separação conjugal, roubo, acidente, migração e perda do emprego no ano anterior à entrevista, foi investigada entre 3.942 pessoas maiores de vinte anos de idade. A análise por regressão logística seguiu modelo hierárquico incluindo, no primeiro nível, características sócio-demográficas individuais; no segundo, eventos estressantes e, no terceiro, o mal-estar psicológico. Acidente e migração não se associaram ao desfecho. O maior efeito foi para separação conjugal (OR ajustada de 2,34. Os mais altos riscos atribuíveis na população foram os das variáveis sócio-econômicas (escolaridade 38,2% e renda 32,3% e o da ocorrência de pelo menos um dos eventos (36,4%. Atuação no plano das políticas públicas, visando a reduzir a ocorrência de eventos sociais negativos e, no plano individual, auxiliando as pessoas a lidar melhor com estes fatos da vida, poderiam contribuir para reduzir substancialmente a sensação de mal-estar psicológico.A cross-sectional study was conducted in 1999 to investigate the association between stressful psychosocial events and psychological distress. A Faces Scale was used to measure the outcome. Death and illness in the family, divorce, robbery, injury, migration, and loss of employment in the previous year were investigated through interviews with 3,942 individuals over 20 years. Logistic regression followed a hierarchical model using socio-demographic characteristics at the first level; psychosocial events at the second; and psychological distress at the third. Injury and migration were not associated with the outcome. The strongest effect was associated with divorce (adjusted OR = 2.34. The highest population-attributable risks were

  12. Preliminary data from {gamma}-cardiography during the abatement of an asthmatic attack (1961); Premieres donnees de la {gamma}-cardiographie au decours de l'etat de mal asthmatique (1961)

    Energy Technology Data Exchange (ETDEWEB)

    Georges, R.; Vernejoul, P. de; Raynaud, C.; Blanchon, P.; Kellershohn, C.; Turiaf, J. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1961-07-01

    The authors used gamma cardiology during the abatement of 16 cases of asthma with a view to detecting heart attacks not otherwise visible with routine methods of examination: clinical, radiological and electro-cardio-graphical. In gamma cardiology, a radioactive indicator is used and its path followed in the cavities of the heart. The method makes it possible to study the circulation in the right heart, the pulmonary crossing, and the left heart, as well as evaluation of the heart-flow. As a result of their investigations the authors, after having discussed the significance of the data obtained with the method, suggest that it is possible by the use of gamma cardiography during the abatement of an asthma attack: 1- To confirm attacks of the right heart which have already been detected by ordinary methods. 2- To confirm the presence of modifications in the recorded curves which suggest, in the case of the left heart, possible attack; such on attack is also indicated, in a small number of cases, by electrocardiography curves. Some considerations are put forward by the authors concerning the physiopathology of attacks on the left heart. (authors) [French] Les auteurs ont fait appel a la gammacardiographie au decours de 16 cas d'etat de mal asthmatique, dans le but d'objectiver des atteintes cardiaques incapables d'etre revelees par les moyens d'exploration de routine: cliniques, radiologiques et electrocardiographiques. La gammacardiographie est un procede qui enregistre a l'aide d'un indicateur radioactif, le trajet de celui-ci dans les cavites cardiaques. Elle permet l'etude de la circulation dans le coeur droit, de la traversee pulmonaire, et le coeur gauche, de meme que le calcul du debit cardiaque. Au terme de leurs investigations, les auteurs apres avoir discute la signification des donnees fournies par la methode admettent que la gammacardiographie objective au secours de l'etat de mal asthmatique: 1- La confirmation de l

  13. USO DA GEOESTATÍSTICA NA PROBABILIDADE DE OCORRÊNCIA DO MAL-DO-PANAMÁ EM BANANEIRA PRATA ANÃ GEOSTATISTIC USE OF THE LIKELIHOOD OF THE OCCURRENCE OF PANAMA DISEASE IN BANANA 'PRATA ANÃ'

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    Moises Zucoloto

    2009-06-01

    Full Text Available O objetivo do presente trabalho foi verificar a probabilidade de ocorrência e variabilidade espacial da incidência do mal-do-Panamá em uma área cultivada com bananeira 'Prata Anã' em um ciclo da cultura. O trabalho foi conduzido em uma lavoura comercial no município de Aracruz, estado do Espírito Santo, Brasil. A probabilidade da ocorrência do mal-do-Panamá na área foi avaliada pelo método de interpolação krigagem indicativa, que é um processo básico de krigagem. Para atingir este objetivo, o primeiro passo, foi a transformação de plantas com ocorrência da doença igual a 1 (um e da não ocorrência da doença igual a 0 (zero. A incidência da doença apresentou dependência espacial de 10 m e com ajuste do modelo exponencial aos dados, o que permitiu estimar por krigagem indicativa a probabilidade de ocorrência da doença na área com a construção do mapa, tornando-se uma ferramenta importante para otimizar as medidas preventivas.This research was carried out to assess the likelihood and spatial variability in the incidence of disease Panama in an area cultivated with banana 'Prata Anã'' in a cycle of culture. The work was conducted on a commercial farm in the municipality of Aracruz, state of Espírito Santo, Brazil. The probability of occurrence of Panamá disease in the area was evaluated by means of kriging interpolation indicative, which is a basic process of kriging. To achieve this goal, the first step was the transformation of plants with occurrence of disease equal to one (1 and the occurrence of the disease does not equal to 0 (zero. The incidence of the disease showed spatial dependence of 10 m with the exponential model fit the data, allowing for kriging indicative estimate the probability of occurrence of the disease in the area with the construction of the map, making it an important tool to optimize the preventive measures.

  14. Malária no município de Humaitá, estado do Amazonas: XXI. Prevalência da deficiência de glicose-6-fosfato desidrogenase (G6PD) Em amostra da população e em doentes com malaria causada pelo Plasmodium falciparum

    OpenAIRE

    Benedito Barraviera; Domingos Alves Meira; Paulo Eduardo de Abreu Machado; Paulo Roberto Curi

    1987-01-01

    Os autores estudaram a prevalência da deficiência de glicose-6-fosfato desidrogenase (G6PD), pelo método de BREWER et alii, em 141 indivíduos da população do município de Humaitá, Estado do Amazonas. Destes, 128 eram amazônides, 67 dos quais nunca tiveram malária, enquanto que 61 tinham tido ou estavam tendo a doença; os 13 restantes que estavam com malária não eram arnazônides. Os resultados revelaram que 7 arnazônides (4,96%), eram deficientes. Destes, 5 eram do sexo feminino e 2 do masculi...

  15. Alterações clínicolaboratoriais em pacientes com malária por Plasmodium vivax e deficiência de glicose-6-fosfato desidrogenase tratados com 0,50mg/kg/dia de primaquina Clinical and laboratorial alterations in Plasmodium vivax malaria patients and glucose-6-phosphate dehydrogenase deficiency treated with primaquine at 0.50mg/kg/day

    OpenAIRE

    Mônica C.M. Silva; Eliane B. Santos; Elenild G. Costa; Manoel G. S. Filho; Guerreiro, João F.; Póvoa, Marinete M.

    2004-01-01

    O efeito adverso da primaquina na dose de 0,50mg/kg/dia foi investigado em onze pacientes com malária vivax (três com deficiência de glicose-6-fosfato desidrogenase). Alterações clínicas e laboratoriais indicaram hemólise aguda apenas nos enzimopênicos, o que fez com que o tratamento fosse interrompido. Nossos resultados sugerem a necessidade do emprego de um teste de triagem para a deficiência de G6PD em áreas endêmicas de malária vivax a fim de se evitar complicações causadas pelo uso da pr...

  16. Sağmal İneklerin Meme Başı Derileri ve Çiğ Sütlerinden İzole Edilen Staphylococcus aureus’ların Patojenite Özellikleri ile Bazı Antibiyotiklere Duyarlılıkları / The Pathogenic Properties and the Varied Antibiotic Sensitivities of S. aureus Isolated from T

    OpenAIRE

    Alişarlı, Mustafa; SOLMAZ, Hasan

    2011-01-01

    ÖZET: Bu çalışmada, sağmal ineklerin meme başı derileri ve çiğ süt örneklerinde Staphylococcus aureus’un yaygınlığı ve izole edilen S. aureus’ların termonükleaz ve enterotoksijenik özellikleri ile bunların bazı antibiyotiklere duyarlılıkları araştırılmıştır. Bu amaçla, Van ili çevresindeki 5 farklı çiftlikten 100 sağmal süt ineğine ait 100 adet çiğ süt (80 adet süt örneği California Mastitis Tes...

  17. Réaction du polyisobutène chloré sur l'anhydride maléique : mécanisme. Catalyse par l'anhydride dichloromaléique Reaction of Chlorinated Polyisobutene on Maleic Anhydride. Mechanism. Catalysis by Dichloromaleic Anhydride

    OpenAIRE

    Sillion B.; Weill J.

    2006-01-01

    Dans cet article le mécanisme de la réaction de condensation du polyisobutène chloré sur l'anhydride maléique, qui sert dans la synthèse d'additif pour lubrifiant, est étudié par une cinétique globale et par un travail sur composés modèles. Il est montré que, dans cette réaction, l'anhydride maléique joue un double rôle : de catalyseur de déshydrochloration par une réactivité de type acide de Lewis organique, de réactif comme diénophile. Grâce à ces résultats, il est proposé une catalyse par ...

  18. A ocorrência de malária em quatro municípios do estado do Pará, de 1988 a 2005, e sua relação com o desmatamento Occurrence of malaria in four cities in the state of Pará during 1988 to 2005 and its relationships with deforestation

    OpenAIRE

    Andressa Tavares Parente; Everaldo Barreiros de Souza; João Batista Miranda Ribeiro

    2012-01-01

    O objetivo deste trabalho foi estudar a ocorrência de malária em quatro diferentes regiões representativas do estado do Pará, buscando suas possíveis relações com as taxas de desmatamento. Foi realizado um estudo retrospectivo, com dados secundários, no período de 1988 a 2005, através de casos de malária registrados em quatro municípios do Estado (Anajás, Itaituba, Santana do Araguaia e Viseu), como também das taxas de desmatamento fornecidas pelo PRODES-INPE. Aplicou-se a técnica dos Quantis...

  19. Reclassificação dos grupos de causas prováveis dos óbitos de causa mal definida, com base nas Autorizações de Internação Hospitalar no Sistema Único de Saúde, Estado do Rio de Janeiro, Brasil

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    Teixeira Claudio Luiz dos Santos

    2006-01-01

    Full Text Available Este artigo descreve características sócio-demográficas e clínicas dos óbitos classificados como de causa mal definida, ocorridos no Estado do Rio de Janeiro, Brasil, em 1998, e faz a reclassificação dos grupos de causas prováveis desses óbitos, com base nas informações contidas nas Declarações de Óbito do Sistema de Informações de Mortalidade e do Sistema de Informações Hospitalares do Sistema Único de Saúde (SIH-SUS de 1997 e 1998. Para isso, foi necessário relacionar uma amostra aleatória de óbitos de causas definidas com o SIH-SUS. Foi utilizada técnica de relacionamento probabilístico de registros. Comparando com os óbitos de causa definida, os óbitos de causa mal definida ocorreram mais em indivíduos de cor da pele não branca e com menor escolaridade; foram mais frequentes na região metropolitana e os indivíduos internaram menos no SUS e morreram mais em domicílios, e sem assistência médica. Foi possível reclassificar cerca de 20% dos óbitos de causa mal definida. A reclassificação apresentou pequeno impacto na mortalidade proporcional, por causa do tamanho deste grupo (10% dos óbitos. No entanto, se os resultados pudessem ser aplicados ao total de óbitos de causa mal definida, poderiam ocorrer alterações de maior impacto na mortalidade proporcional.

  20. Sequence and phylogenetic analysis of genome segments S1, S2, S3 and S6 of Mal de Río Cuarto virus, a newly accepted Fijivirus species.

    Science.gov (United States)

    Distéfano, Ana J; Conci, Luis R; Muñoz Hidalgo, Marianne; Guzmán, Fabiana A; Hopp, Horacio E; del Vas, Mariana

    2003-03-01

    Mal de Río Cuarto virus (MRCV) is a newly described species of the genus Fijivirus, family Reoviridae. The nucleotide sequence of four MRCV genome segments was determined. MRCV S1, S2, S3 and S6 were predicted to encode proteins of 168.4, 134.4, 141.7 and 90 kDa, respectively. MRCV S1 encodes a basic protein that contains conserved RNA-dependent RNA polymerase motifs, and is homologous to Rice black streaked dwarf virus (RBSDV), Fiji disease virus (FDV) and Nilaparvata lugens reovirus (NLRV) polymerases as well as to corresponding proteins of members of other genera of the Reoviridae. MRCV S2 codes for a protein with intermediate homology to the ones coded by RBSDV S4 and FDV S3 'B' spike, which is presumably the B-spike protein. MRCV S3 most probably encodes the major core protein and is highly homologous to corresponding proteins of RBSDV S2 and FDV S3. MRCV S6-encoded protein has low homology to the proteins of unknown function coded by RBSDV S6 and FDV S6. The identity levels between all analyzed MRCV coded proteins and their RBSDV counterparts varied between 84.5 and 44.8%. The analysis of the reported sequences allowed a phylogenetic comparison of MRCV with other reovirus and supported its taxonomic status within the genus.

  1. Sequence analysis of genome segments S4 and S8 of Mal de Río Cuarto virus (MRCV): evidence that the virus should be a separate Fijivirus species.

    Science.gov (United States)

    Distéfano, A J; Conci, L R; Muñoz Hidalgo, M; Guzmán, F A; Hopp, H E; del Vas, M

    2002-09-01

    This is the first sequence-based characterization of Mal de Río Cuarto virus (MRCV), currently classified as a variant of Maize rough dwarf virus (MRDV) and exclusively found in South America. We sequenced and analyzed genome segments S4 and S8. MRCV S4 coded for a putative 131.67 kDa protein while MRCV S8 coded for a putative 68.26 kDa protein containing an ATP/GTP-binding motif. The 5' and 3' ends of MRCV segments, were 5'AAGUUUUU3' and 5'CAGCUnnnGUC3', respectively. Prediction of secondary structure of both segments coding strands showed that terminal regions were able to form structures that are proposed to be replication and packaging signals. MRCV S4 showed identity to members of Fijivirus as well as to two other genera of the Reoviridae family. MRCV S8 revealed identity with Rice black streaked dwarf virus (RBSDV) S8, MRDV S7, Oat sterile dwarf virus (OSDV) S9 and Nilaparvata lugens reovirus (NLRV) S7. While MRDV and RBSDV segments are highly homologous between each other, MRCV identity levels with them was considerably lower. We discussed the evolutionary relationships of MRCV to other Reoviridae, and based on phylogenetic analysis we proposed that although MRCV is related to MRDV, it could be regarded as a new species of the Fijivirus genus.

  2. Analýza výkaznictví cenných papírů malými a středními podniky v ČR

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    Strouhal Jiří

    2011-05-01

    Full Text Available Z důvodu nadnárodní účetní harmonizace lze v posledních letech vysledovat odklon od tradičního oceňování na bázi historických cen směrem k vykazování v reálných hodnotách. Tento trend je v českém účetnictví zejména aplikován na oblast oceňování a vykazování cenných papírů. Cílem tohoto příspěvku je zhodnotit stávající stav využití cenných papírů malými a středními podniky, zhodnotit jejich schopnost ocenit tyto finanční nástroje a v neposlední řadě provést komparativní analýzu českých účetních pravidel s pravidly nadnárodními, konkrétně pak Mezinárodními standardy účetního výkaznictví (IFRS.

  3. Intervención familiar para el manejo psicológico en pacientes oncológicos con mal pronóstico en el hospital de la Misericordia

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    Ana Carolina Rodríguez Ibarra

    2004-01-01

    Full Text Available Se diseñó un programa fundamentado en el modelo cognitivo conductual de Inoculación de Estrés e intervención en duelo anticipatorio basado en cuatro tareas. El programa fue aplicado a tres pacientes con mal pronóstico del Servicio de Oncohematología del Hospital de la Misericordia y a sus familias. Por medio de estudio de caso, se describieron factores de riesgo y de protección así como respuestas frente a dicha intervención. El análisis cualitativo de casos arrojó la descripción de respuestas a pérdidas previas no elaboradas, pautas de comunicación deficiente en uno de los casos, y reconocimiento de apoyo al interior de cada familia. Según el reporte de los participantes, la intervención permitió la expresión de sentimientos, la reflexión sobre el sentido de la vida, incremento de posibilidades y habilidades de comunicación y orientación hacia la solución de problemas y toma de decisiones.

  4. Studie využití pomaloběžných větrných turbín pro malé a střední aplikace

    OpenAIRE

    Forró, Bálint

    2009-01-01

    Bakalářská práce se zabývá využitím pomaloběžných větrných turbín pro malé a střední aplikace, přesněji pak o Savonionův typ rotoru. V první části jsem se věnoval teoretickému využití větru a k analýze druhů větrných elektráren. V další části jsem zabýval popisem výhod a nevýhod Savonionova větrného rotoru a jeho praktickým využitím. Práci jsem zakončil konstrukčním návrhem větrného rotoru tohoto typu pro daný výkon při určité rychlosti větru. Bachelor’s thesis deals with usage of slow-run...

  5. The Byzantines in Medieval Arabic Poetry: Abu Firas’ "Al-Rumiyyat" and the Poetic Responses of al-Qaffal and Ibn Hazm to Nicephore Phocas’ "Al-Qasida al-Arminiyya al-Malʿuna" (The Armenian Cursed Ode

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    Nizar F. HERMES

    2009-10-01

    Full Text Available Up until the Crusades, it was al-Rūm who were universally seen by Arab writers and Arab poets in particular as the Other par excellence. Nowhere is this more conspicuous than in the sub-genre of Al-Rūmiyyat (poems about the Byzantines, namely as found in the Rūmiyyat of Abu Firas al-Hamdani(d.968, and in the poetic responses of al-Qaffal(d. 946 and Ibn Hazm(d. 1064 to what was described by several medieval Muslim chronicles as Al-Qasida al-Arminiyya al-Malʿuna (The Armenian Cursed Ode. By exploring the forgotten views of the Byzantines in medieval Arabic poetry, this article purports to demonstrate that contrary to the impression left after reading Edward Said’s groundbreaking Orientalism: Western Conceptions of the Orient (1978 and other postcolonial studies, Orientals have not existed solely to be ‘orientalized’. Perhaps even before this came to be so, they too had ‘occidentalized’ their Euro-Christian Other(s in a way that mirrored in reverse the subject/object relationship described as Orientalism.

  6. Assessing the effects of global warming and local social and economic conditions on the malaria transmission Quantificando os efeitos do aquecimento global e das condições socioeconômicas locais na transmissão de malária

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    Hyun M Yang

    2000-06-01

    Full Text Available OBJECTIVE: To show how a mathematical model can be used to describe and to understand the malaria transmission. METHODS: The effects on malaria transmission due to the impact of the global temperature changes and prevailing social and economic conditions in a community were assessed based on a previously presented compartmental model, which describes the overall transmission of malaria. RESULTS/CONCLUSIONS: The assessments were made from the scenarios produced by the model both in steady state and dynamic analyses. Depending on the risk level of malaria, the effects on malaria transmission can be predicted by the temperature ambient or local social and-economic conditions.OBJETIVO: Apresenta-se um modelo matemático mostrando como esse instrumento pode ser importante para descrever a transmissão de malária. MÉTODOS: Baseado no modelo proposto previamente, foram quantificados os efeitos de dois fatores que podem afetar a transmissão da malaria: a temperatura ambiente e as condições socioeconômicas locais. RESULTADOS/CONCLUSÕES: A quantificação foi feita estudando o modelo proposto no estado estacionário e na sua dinâmica. Dependendo do nível de risco de malária, os principais efeitos na transmissão de malária são devidos à temperatura ambiente ou às condições socioeconômicas.

  7. Validez de la Escala de Memoria Wechsler con una muestra previamente diagnosticada con enfermedad de Alzheimer

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    Aurealis T. Báez

    1995-01-01

    Full Text Available El presente estudio fue un intento inicial y exploratorio de traducción y adaptación de la Escala de Memoria Wechsler Forma 1(Wechsler, 1945 en una muestra de origen puertorriqueño. Se postuló que en todas las subescalas de la Escala de Memoria Wechsler habría diferencias significativas entre las puntuaciones obtenidas por los pacientes previamente diagnosticados con la enfermedad de Alzheimer y el grupo de personas neurológicamente normales. El grupo previamente diagnosticado con la enfermedad de Alzheimer fue provisto por un neurólogo independiente del estudio. La muestra del estudio estuvo constituida por 20 pacientes con una edad promedio de 72 años y 20 personas neurológicamente normales con una edad promedio de 66 años. Se le administraron tres instrumentos, un cuestionario de datos sociodemográficos, el Barranquilla Rapid Survey Intelligence Text (BARSIT y una traducción adaptada a Puerto Rico de la Escala de Memoria Wechsler FonnaI original de 1945. Los resultados arrojaron diferencias significativas entre las puntuaciones del grupo de pacientes y el grupo neurológicamente normal en todas las subescalas de la Escala de Memoria Wechsler con excepción de la subescala de Memoria Visual. Las puntuaciones del grupo diagnosticado fueron más bajas que las del grupo normal. Los resultados apoyan la sensibilidad de esta escala en la medición de las alteraciones de la memoria relacionadas con la enfermedad de Alzheimer. Las implicaciones de este estudio podrían estar relacionadas a tres áreas de importancia dentro del campo de la psicología y neuropsicología clínicas las cuales son: la evaluación, el diagnóstico y el tratamiento de estos pacientes y su relevancia en la comprensión, manejo y calidad de vida de los mismos

  8. Proceso emocional y niveles de ansiedad en personas diagnosticadas de Trastorno de la Conducta Alimentaria

    OpenAIRE

    Azabal Sánchez, Beatriz

    2014-01-01

    Los trastornos de la Conducta alimentaria son una enfermedad que actualmente se ha extendido y está siendo más conocida, sobre todo la anorexia nerviosa o la bulimia. Por ello, existen más estudios y a su vez más terapias centradas específicamente en este tipo de trastorno, el cuál desencadena otros problemas en la persona, como puede ser la ansiedad. En este trabajo se lleva a cabo una investigación cuyo objetivo principal es analizar de qué manera influye el proceso de Arteterapia en el pro...

  9. Tubal and peritoneal alterations diagnosed by hysterosalpingography; Alteraciones tubaricas y peritoneales diagnosticadas por histerosalpingografia

    Energy Technology Data Exchange (ETDEWEB)

    Monzon, M.; Ubeda, B.; Paraira, M.; Abuin, R. A.; Alert, E. [Institut Universitari Dexeus. Barcelona (Spain)

    2001-07-01

    In the evaluation of the multiple causes that contribute to infertility tubal and peritoneal factors are responsible for 25-40% of cases. Hysterosalpingography is the most reliable method in the evaluation of tubal morphology and patency, although it presents a lower sensibility in the assessment of pelvic adhesions. The purpose of this review is to describe the most frequent tubal and peritoneal abnormalities found in hysterosalpingography. We have reviewed the hysterosalpingography performed at our institution between January 1988 until December 1999 in patients undergoing evaluation for infertility, and the most representative images of the different pathologic entities have been chosen. (Author) 7 refs.

  10. ENFERMIDADES DIAGNOSTICADAS NA GENITÁLIA EXTERNA DE TOUROS: ESTUDO RETROSPECTIVO (2007 – 2013

    Directory of Open Access Journals (Sweden)

    Luiz Antônio Franco da Silva

    2015-01-01

    Full Text Available Despite the importance of knowing epidemiological data on diseases that affect the external genitalia of bulls, few investigations have been conducted on the topic. This work aimed to conduct an epidemiological study of diseases diagnosed in the external genitalia of bulls in 215 farms distributed in the five mesoregions of the state of Goiás, Brazil, between 2007 and 2013. We verified that the largest number of cases were observed at southwestern region (64 %, followed by the northwestern region (18.5 %. We found that of the affected bulls, 156 (71.89 % were Zebu, 47 (21.66% taurine and 14 (6.45 % were mixed breeds. Among the diseases, acropostite-phimosis was the more frequent, followed by fibropapiloma of the glans, prepuce abscess and penile fracture. The main risk factors were multifactorial aspects, including the morphological condition of the animals, environment, management and traumas. In many cases, the absence or insufficient number of trained veterinarians who work on the field was mentioned as one of the major bottlenecks for the realization of the diagnosis, treatment and prevention of diseases, preventing premature disposal of the animals.

  11. Listeriosis neonatal: ¿enfermedad poco frecuente o no diagnosticada? Enfoque microbiológico

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    Andrey Payán

    2014-11-01

    Full Text Available Listeria monocytogenes es un bacilo Gram positivo con una amplia distribución en la naturaleza, que puede causar enfermedad en el ser humano. El microorganismo tiene la capacidad de sobrevivir dentro de las células fagocíticas que infecta, lo que se considera uno de los principales factores de virulencia. Se ha establecido que en epidemias la principal fuente de infección para el hombre son los alimentos contaminados. Casi todas las infecciones en el adulto ocurren en individuos con algún grado de inmunodeficiencia aunque también se denomina granulomatosis infantil séptica que muestra alta mortalidad. En niños mayores y adultos también produce meningitis. Debido a que la enfermedad se presenta con baja frecuencia y las características clínicas no son específicas, al hacer el diagnóstico por laboratorio, la similitud de la Listeria con otras bacterias en cultivo y en examen directo llevan frecuentemente a establecer un diagnóstico erróneo. Su identificación es simple y fácil de realizar si se tiene la sospecha microbiológica. Este trabajo se ilustra con un caso de listeriosis neonatal que se presentó en el Hospital Universitario del Valle en el mes de julio de 1993 y se hace énfasis en el diagnóstico por laboratorio.

  12. Enfermidades diagnosticadas em bezerros na região sul do Rio Grande do Sul

    OpenAIRE

    2013-01-01

    O objetivo deste estudo foi relatar a frequência das enfermidades que ocorrem em bovinos até um ano de idade na área de influência do Laboratório Regional de Diagnóstico (LRD) da Faculdade de Veterinária da Universidade Federal de Pelotas (UFPel) estabelecendo os principais fatores epidemiológicos associados à ocorrência dessas enfermidades. Foram revisados os protocolos de necropsias realizadas e de materiais de bovinos até um ano de idade, encaminhados ao LRD/UFPel entre 2000 e 2011. Em 35,...

  13. Malaria vectors in the Brazilian Amazon: Anopheles of the subgenus Nyssorhynchus Anopheles do subgênero Nyssorhynchus, vetores da malária na Amazônia brasileira

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    Wanderli Pedro TADEI

    2000-04-01

    Full Text Available Various species of Anopheles (Nyssorhynchus were studied in the Amazon with the objective of determining their importance as malaria vectors. Of the 33 known Anopheles species occurring in the Amazon, only 9 were found to be infected with Plasmodium. The different species of this subgenus varied both in diversity and density in the collection areas. The populations showed a tendency towards lower density and diversity in virgin forest than in areas modified by human intervention. The principal vector, An. darlingi, is anthropophilic with a continuous activity cycle lasting the entire night but peaking at sunset and sunrise. These species (Nyssorhynchus are peridomiciliary, entering houses to feed on blood and immediately leaving to settle on nearby vegetation. Anopheles nuneztovari proved to be zoophilic, crepuscular and peridomiciliary. These habits may change depending on a series of external factors, especially those related to human activity. There is a possibility that sibling species exist in the study area and they are being studied with reference to An. darlingi, An. albitarsis and An. nuneztovari. The present results do not suggest the existence of subpopulations of An. darlingi in the Brazilian Amazon.Várias espécies de Anopheles (Nyssorhynchus foram estudadas na Amazônia a fim de se determinar sua importância na transmissão da malária. Das 33 espécies de Anopheles de ocorrência conhecida na Amazônia, apenas 8 foram encontradas infectadas por Plasmodium. O principal vetor, An. darlingi, é antropofílico com um ciclo contínuo de atividade que dura a noite inteira mas que tem picos ao anoitecer e ao amanhecer. As diferentes espécies desse subgênero variaram tanto em diversidade como em densidade nas áreas de coleta. A população de anofelinos apresentou tendências de menor densidade e diversidade em florestas virgens do que em áreas que sofreram intervenção humana. Essas espécies (Nyssorhynchus são peridomiciliares

  14. A crítica de Alexis Philonenko ao "mal-estar" sartriano: em defesa do humanismo The criticism of Alexis Philonenko to the sartrian's malaise: in defense of the humanism

    Directory of Open Access Journals (Sweden)

    Malcom G Rodrigues

    2010-01-01

    Full Text Available O objetivo do artigo é discutir a crítica de Philonenko (1981 aos conceitos sartrianos de "má-fé" e "liberdade". Um dos pilares dessa crítica é a defesa da noção de "coerência do estilo", elemento indispensável para resguardar a autenticidade tão prezada por Sartre, segundo Philonenko. Contudo, continua este último, ao afirmar "eu não sou jamais nenhuma de minhas condutas, nenhuma de minhas atitudes", Sartre limita a liberdade por ele defendida ao horizonte de uma maliciosa dissimulação, quer dizer, da má-fé. Nós constatamos três imprecisões nessa crítica. Em primeiro lugar, a citada afirmação de Sartre foi mal interpretada. Mas, em segundo, se essa interpretação está correta, supondo que o estilo seja indispensável à autenticidade, ainda assim a liberdade sartriana não pode ser "para o mal", pois ela se caracteriza, em termos ontológicos, como o próprio ser da realidade humana "em situação", e não em termos morais, como uma propriedade dessa realidade, cristalizada por um olhar atento sobre si ou sobre o outro, e julgada como boa ou má. Por fim, queremos concluir que, numa possível conduta autêntica, a derrocada da má-fé não apenas prescinde do amparo a uma coerência do estilo como também pressupõe o reconhecimento angustiante de sua gratuidade.The aim of this paper is to discuss the Philonenko's criticism (1981 to the sartrian's concepts of "bad-faith" and "freedom". One of the pillars of this criticism is to defend the notion of "coherence of style", an indispensable element to safeguard the authenticity so relevant for Sartre, according Philonenko. However, when Sartre says "I'm not ever any of my conduct, none of my actions", limits the freedom advocated by himself on the horizon of a malicious deception, that is, the horizon of bad- faith. We found three inaccuracies in this criticism. First, the statement aforementioned of Sartre was misinterpreted. But secondly, if this interpretation is correct

  15. Resistência à mefloquina do tipo RIII em crianças com malária falciparum em Manaus, AM, Brasil RIII mefloquine resistance in children with falciparum malaria in Manaus, AM, Brazil

    Directory of Open Access Journals (Sweden)

    Elza Noronha

    2000-04-01

    Full Text Available Relata-se a ocorrência de resistência à mefloquina administrada na dose de 20mg/kg em 51 crianças com malária falciparum atendidas em centro de referência em Manaus, Brasil, no período de outubro a novembro de 1997. Todas as crianças foram avaliadas nos dias 3, 5, 7, 14, 21, 28 e 35 do tratamento, segundo critérios clínico e parasitológico. Foi encontrada uma incidência de resistência RIII de 5,9% (IC 95% variando de 1,5 a 17,2, a razão cura/resistência calculada foi 20:1 e cura/gravidade 62:1. Os dados chamam a atenção para a importância da resistência à mefloquina nesse grupo de crianças.We report the occurrence of resistance to mefloquine 20mg/day in 51 children with falciparum malaria treated, at reference center of Manaus, Brazil, from October to December 1997. All children were evaluated at day 3, 5, 7, 14, 21, 28 and 35 of treatment. Clinical and parasitological cure criteria were adopted. The incidence of RIII mefloquine resistance was 5.9% (IC 95% 1.5-17.2. The cure/resistance proportion was 20:1 and cure/severity was 62:1. These findings suggest the importance of mefloquine resistance within this group of children.

  16. Enfermedades pleurales benignas inducidas por asbesto Benign pleural diseases induced by asbestos

    OpenAIRE

    J. Boldú; V. M. Eguía

    2005-01-01

    La exposición al asbesto es una causa importante de patología pleural y se puede producir con intensidades moderadas o ligeras dada la capacidad del asbesto de concentrarse en la pleura. Ello motiva junto a la prolongada latencia existente entre la exposición y la enfermedad, que sigamos viendo durante muchos años manifestaciones clínicas pleurales de exposición previa, a pesar del uso del asbesto cada vez más limitado en las últimas décadas. Dicha exposición puede presentarse con distintas m...

  17. Endometriose intestinal: uma doença benigna? Bowel endometriosis: a benign disease?

    Directory of Open Access Journals (Sweden)

    Marco Antonio Bassi

    2009-01-01

    Full Text Available A despeito do caráter benigno da endometriose, estima-se que 1% dos casos esteja relacionado com câncer, especialmente quando ambas as condições ocorrem nos ovários. Lesões extra-ovarianas encontradas no septo retovaginal, cólon, bexiga, vagina e peritônio da região pélvica também já foram associadas com neoplasias malignas. Várias características do tecido endometrial ectópico o aproximam do fenótipo neoplásico, e a própria endometriose possui comportamento tipicamente neoplásico com capacidade de invasão do estroma adjacente e associação com lesões à distância. Esta revisão atualiza conhecimentos diagnósticos, clínicos e terapêuticos dos implantes intestinais de tecido endometriótico, bem como sua relação com processos neoplásicos para melhor compreensão de seu caráter benigno ou de seu eventual potencial para malignidade.Endometriosis is generally assumed to be a benign disease, but it is estimated that 1% of cases are associated with cancer, especially when both conditions are present in the ovary. Extra-ovarian lesions in the rectovaginal septum, colon, bladder, vagina and peritoneum were already associated with malign neoplasia. Several characteristics of endometrial tissue are very similar to the neoplasia phenotype. Endometriosis itself typically behaves as a neoplasia process, spreading over adjacent stroma and being associated with distant lesions. This is an update on the diagnostic, clinical, and therapeutic knowledge of, management of bowel implants of endometrial tissue, as well as the relation with neoplastic processes to better understand its benign nature or eventual potential for malignancy.

  18. Hipertrofia benigna do músculo masseter Benign masseter muscle hypertrophy

    Directory of Open Access Journals (Sweden)

    Daniel Zeni Rispoli

    2008-10-01

    Full Text Available A hipertrofia idiopática do músculo masseter (HIM é uma patologia pouco freqüente e de causa desconhecida. Alguns autores correlacionam tal condição com hábitos de mascar gomas, disfunção da articulação temporomandibular (ATM, hipertrofias congênitas e funcionais, e distúrbios emocionais (nervosismo e ansiedade. A maioria dos pacientes queixa-se da alteração estética decorrente da assimetria facial, também chamada "face quadrada", no entanto, sintomas como trismo, protrusão e bruxismo também podem ocorrer. Os objetivos deste estudo foram: relatar um caso de HIM e descrever a sintomatologia e o tratamento realizado. O paciente relatava aumento bilateral na região do ângulo da mandíbula de evolução lenta e progressiva. Negava dor ou desconforto, porém se queixava de otalgia bilateral, trismo noturno e ansiedade. Ao exame físico, observou-se hipertrofia bilateral de masseter sem alterações inflamatórias no local. Foi indicado tratamento cirúrgico com abordagem extra-oral. Exames complementares são indicados na dúvida diagnóstica. A conduta terapêutica varia de conservadora a cirúrgica, sendo que esta depende principalmente da experiência e da habilidade do cirurgião.Idiopathic hypertrophy of the masseter muscle is a rare disorder of unknown cause. Some authors associate it with the habit of chewing gum, temporo-mandibular joint disorder, congenital and functional hypertrophies, and emotional disorders (stress and nervousness. Most patients complain of the cosmetic change caused by facial asymmetry, also called square face, however, symptoms such as trismus, protrusion and bruxism may also occur. The goals of the present investigation were: to report a case of idiopathic masseter hypertrophy, describe its symptoms and treatment. The patient reported bilateral bulging in the region of the mandible angle, of slow and progressive evolution. He did not complain of pain or discomfort, however there was bilateral otalgia, nighttime trismus and stress. In his physical exam we noticed bilateral masseter hypertrophy without local inflammatory alterations. We indicated surgical treatment with an extraoral approach. Complementary tests are indicated when there is diagnostic doubts. Treatment varies from conservative to surgical, and the later depends on surgeon skill and experience.

  19. O mal-estar no trabalho: a culpa como mal-estar e a culpa do mal-estar

    Directory of Open Access Journals (Sweden)

    Waldir Périco

    2011-01-01

    Full Text Available Este trabajo es una investigación teórica-reflexiva que busca, a la luz de la teoría psicoanalítica y Freud-marxista, pensar sobre el malestar en el local de trabajo - efectos de una civilización represiva -, así como sus posibilidades sublimatorias, en el contexto de los debates del conflicto individuo-civilización. El trabajo da al hombre la clave de su representación de sí y del mundo. Las investigaciones actuales demuestran la importancia de tomar en cuenta el trabajo para la comprensión del proceso salud/enfermedad tanto física como mental, así como la subjetividad del hombre de hoy. Sin embargo las organizaciones laborales, con un entendimiento reduccionista, y teniendo como cómplice el saber/poder médico-siquiátricos, tienden a ignorar su parte de responsabilidad en la "producción" de enfermedades entre los trabajadores, especialmente las relativas al psíquico. Freud, empezando com la comprensión de las neurosis, demonstro que en el conflicto individuo-civilización el primer paga un alto precio: el malestar constante (la culpa como malestar. Mientras que los dueños de la culpa, en el sentido social de la palabra (culpa del malestar, es la cultura humana, mediada por las organizaciones, que defienden los intereses de la minoria dueña de los medios de producción/explotación. Para Freud, el crecimiento de la culpa es inevitable dada la necesidad de la represión de las pulsiones para el progreso cultural através del trabajo desplaceroso. Sin embargo, Reich y Marcuse teorizan una salida para el pesimismo freudiano acerca del conflicto entre el individuo y la civilización. Freud no habría pesado adecuadamente la naturaleza sociohistórica del principio de la realidad, dada esta universal. Por lo tanto, el nivel de represión posee clase socioeconômica especifica: plusvalor para la minoria y plusrepresion para las grandes masas. Un principio de la realidad menos represivo podría proporcionar un progreso cultural más justo y humanizado. Sigue, como siempre, en el orden del día la posibilidad de trabajar en las condiciones sociales y psicológicas que permiten la reducción del malestar de las masas de trabajadores em el seno de la civilización.

  20. Gibbosité vertébrale congénitale évoquant un mal de Pott chez un nouveau-né de mère tuberculeuse: à propos d'un cas et revue de la literature

    Science.gov (United States)

    Katamea, Tina; Mukuku, Olivier; Luboya, Oscar Numbi

    2014-01-01

    Les formes latentes de tuberculose chez la femme enceinte sont associées à un risque élevé de passage à une forme active qui augmente le risque de transmission de la mère infectée à l'enfant dans les 3 premières semaines de vie. Nous rapportons un cas de Gibbosité vertébrale congénitale évoquant un mal de Pott chez un nourrisson de mère tuberculeuse, observé à Lubumbashi, en République Démocratique du Congo. PMID:25478046

  1. Effects of immigration on the prevalence of malaria in rural areas of the Amazon basin of Brazil Conseqüência da imigração na prevalência da malária nas áreas rurais da bacia Amazônica no Brasil

    OpenAIRE

    Patrick B. Macgreevy; Reynaldo Dietze; Aluísio Prata; Stephen C. Hembree

    1989-01-01

    Epidemiological studies were conducted on malaria in three rural areas of the Amazon basin in the State of Rondônia: the town of Costa Marques, Forte Príncipe da Beira (Fort), and an immigrant settlement in the nearby forest. These studies were instituted to document the malaria problem and to describe the role of immigration on its distribution and prevalence. Hospital records in the town show that the number of malaria cases increased five fold from 1983 to 1987 and that the predominant mal...

  2. Vacinas em desenvolvimento: estreptococo do grupo B, herpes-zóster, HIV, malária e dengue Vaccines under development: group B streptococcus, herpes-zoster, HIV, malaria and dengue

    Directory of Open Access Journals (Sweden)

    Luiz Jacintho da Silva

    2006-07-01

    Full Text Available OBJETIVOS: As vacinas contra o estreptococo B, o herpes-zóster, o HIV, a malária e a dengue, selecionadas por critérios de comercialização iminente ou devido a problemas específicos para sua obtenção, foram objeto de uma revisão sobre o estado atual do seu desenvolvimento. FONTE DOS DADOS:Foi realizada revisão da literatura através da MEDLINE no período de 1996 a 2006, sobre a epidemiologia e imunologia das doenças, analisando tanto os maiores problemas para a obtenção de uma vacina como o estado atual dos estudos, com ênfase para os que estavam em fase mais adiantada. SÍNTESE DOS DADOS: Cada uma das cinco doenças escolhidas apresenta problemas específicos para o desenvolvimento de uma vacina. No entanto, a maioria deles já foi ou está em vias de ser resolvido, permitindo prever que uma vacina - ou vacinas - eficaz e segura estará disponível em futuro próximo. CONCLUSÕES:Apesar dos problemas enfrentados para o desenvolvimento dessas vacinas, os avanços da biologia molecular e da imunologia permitiram superar a maioria deles, abrindo a perspectiva para a obtenção de novas vacinas.OBJECTIVES: To review the current state of development of streptococcus B, herpes-zoster, HIV, malaria and dengue vaccines. These vaccines were selected both because of imminent commercial release and because of specific problems with their development. SOURCES OF DATA: A review of the literature was performed by means of a MEDLINE search, on the period 1996 to 2006, for the epidemiology and immunology of these diseases, analyzing both the greatest obstacles to creating a vaccine and the current state of research, with emphasis on studies in the most advanced stages. SUMMARY OF THE FINDINGS: Each of the five diseases chosen presents specific problems for vaccine development. Nevertheless, in the majority of cases these have been or are in sight of being resolved, allowing for the prediction that a safe and effective vaccine - or vaccines

  3. Assessment of chloroquine single dose treatment of malaria due to Plasmodium vivax in Brazilian Amazon Cloroquina em dose simples no tratamento da malária por Plasmodium vivax na Amazônia brasileira

    Directory of Open Access Journals (Sweden)

    Ana Yecê das Neves Pinto

    2003-12-01

    Full Text Available Malaria regions of the Amazon basin have been characterized by difficult access and non-compliance of the patients to treatment. In an attempt to assess the schizonticide efficacy of chloroquine in a single dose of 600 mg, the authors realized a double-blind, placebo-controlled trial in 132 outpatients with vivax malaria. Patients were distributed into two groups: group CPLA, given chloroquine 600 mg (single dose on the first day of treatment, and two doses of placebo on second and third days. Group CHLO, given chloroquine 600 mg on first day and 450 mg on second and third day. Geometric means of the parasite density during the follow-up was similar in both groups. No differences were observed in the parasitological cure between the two groups (p = 0.442. There was clinical and parasitological efficacy in treatment of patients given a single-dose of chloroquine. This suggests that its restricted use could be indicated in remote areas of Brazilian Amazon Region, nevertheless the inadequate response of three patients indicates the need for further studies.As regiões malarígenas da Amazônia brasileira têm se caracterizado por dificuldades no acesso ao tratamento e não aceitação das drogas pelos doentes. Com objetivos de avaliar a eficácia da cloroquina em dose simples de 600 mg, os autores realizaram um ensaio clínico duplo cego, placebo controlado em 132 pacientes portadores de malária por P. vivax. Os pacientes foram distribuídos em dois grupos: grupo CPLA que recebia 600 mg de cloroquina em dose simples no primeiro dia de tratamento e duas doses de placebo no segundo e terceiro dias de tratamento. Grupo CLO que recebia 600 mg de cloroquina no primeiro dia e 450 mg no segundo e terceiro dias. A média geométrica da densidade parasitária durante o seguimento foi similar em ambos os grupos. Não houve diferenças de cura parasitológica em ambos os grupos (p = 0,442. Observou-se eficácia clínica e parasitológica nos indivíduos que

  4. Relación entre genotipos del grupo sanguíneo duffy e infección malárica en diferentes etnias de Choco-Colombia

    Directory of Open Access Journals (Sweden)

    Lina Gonzalez

    2012-09-01

    Full Text Available Introducción: La condición homocigótica negativa del grupo sanguíneo Duffy (Fy-/Fy- o FYBnull/FYBnull confiere resistencia natural a Plasmodium vivax. En Colombia se han realizado algunos estudios con el grupo Duffy como marcador genético de la etnia afrocolombiana, pero pocos los relacionan con malaria.   Objetivo: describir la frecuencia de los genotipos Duffy en tres comunidades étnicas de La Italia, (San José del Palmar (Chocó, y su relación con la infección malárica. Metodología: estudio descriptivo, transversal con individuos sintomáticos o asintomáticos de malaria. El tamaño muestral de cada etnia fue: afrocolombiana 73; amerindia (emberá 74, “mestiza” (mezcla de dos etnias 171. La infección plasmodial se confirmó con gota gruesa y se realizó PCR y RFLP del gen Duffy. Resultados: en los amerindios y mestizos la frecuencia del alelo T-46 (FY+ fué 0,90-1,00, en afrocolombianos fué 0,50, al igual que el alelo C, con ausencia de heterocigotos. En todas las poblaciones la infección por P. vivax varió entre 1 y 6%. Se encontró significancia estadística al asociar genotipos Duffy con etnia (p=0,003. Los individuos con diplotipos C/C,A/A sólo sufren infección por P. falciparum, mientras que los individuos con los otros diplotipos pueden ser infectados con cualquiera de las dos especies. En el locus 131 la máxima frecuencia del alelo G fue 0,30 en amerindios y la máxima del alelo A fué 0,69 en afrocolombianos. Conclusiones: se confirma estructuración por etnias, reflejando un alto grado de endogamia y discriminación entre las poblaciones. Ningún individuo CC (FY-/FY- fué encontrado con infección por P. vivax.  

  5. Oxygen minimum seafloor ecological (mal) functioning

    Digital Repository Service at National Institute of Oceanography (India)

    Moodley, L.; Nigam, R.; Ingole, B.S.; PrakashBabu, C.; Panchang, R.; Nanajkar, M.; Sivadas, S.; van Breugel, P.; van Ijzerloo, L.; Rutgers, R.; Heip, C.H.R.; Soetaert, K.; Middelburg, J.J.

    Although organic matter (OM) settling on the seafloor is generally rapidly recycled, a key ecological process, large scale burial events manifest itself in the marine sedimentary record as organic carbon (Corg)-rich layers. Presently, this prevails...

  6. Analysis of refrigerant mal-distribution

    DEFF Research Database (Denmark)

    Kærn, Martin Ryhl; Elmegaard, Brian

    2009-01-01

    is developed in the object-oriented modeling language Modelica. The evaporator model is a dynamic distributed one-dimensional homogeneous model, but will be used here to present results in steady state. Fin-and-tube evaporators usually have a complex circuitry, however the evaporator will be simplified...

  7. (MAL)practice of nuclear power economics

    International Nuclear Information System (INIS)

    Nuclear cost evaluations traditionally use the cost of concurrent coal-fired electricity as their benchmark, but these comparisons are now moot because cash-poor utilities aren't shopping for new power plants. A breakeven capital-cost ratio measures the capital cost handicap that a nuclear plant can stand and still break even with coal power by means of its fuel savings. Although different regions have different breakeven ratios, primarily due to variations in coal prices, a national average breakeven ratio can be placed between 1.2 and 1.4, meaning that nuclear plants could stand between a 20 and 40% higher capital cost and still end up with equal lifetime generating cost. The nuclear promoter's failure to represent costs competently and candidly show that there is a need for independent analysis of the economic and other consequences of major public investments. 24 references, 3 figures, 2 tables

  8. Mal de Debarquement (Sickness of Disembarkment)

    Science.gov (United States)

    ... ORG Did this free publication from VEDA help you? Thanks to VEDA , vestibular disorders are becoming recognized for their impacts on lives and our economy. We see new diagnostic tools and research studies, ...

  9. O mal-estar da Gerechtigkeit

    Directory of Open Access Journals (Sweden)

    Luís S. Krausz

    2008-11-01

    Full Text Available Der Fall Maurizius by Jakob Wassermann was first published in 1928. It is set partly in 1908 Germany and partly during the Weimar Republic. In this work, Wassermann criticizes German pragmatism by depicting the State bur eaucracy as the absolute power over citizens, even after the Imperial Era. Disgusted with the mismanagement of the justice system and with the perverse character of those in charge,  the author renders German pragmatism as non-adherence to the moral values supposedly justifying the State apparatus – in particular, as a breach of the Gerechtigkeit principle. The harmless innocence of the adolescent Etzel von Andergast, the only child of a well-known prosecutor,  highlights this violation of justice. At the same time, Waremme is a sinister character whose Jewish parents fled from Prussian-occupied Poland. He breaks with his ancestors’ moral values and is eager to play a key role in the German Nationalistic movement. However, he feels frustrated with his project of cultural assimilation and is pushed towards the outskirts of a bewildered society. The crisis of values and transgression of justice become the emblems of Wassermann’s generation. 

  10. Case 1432: MAL 8(1)

    DEFF Research Database (Denmark)

    Lookofsky, Joseph

    2014-01-01

    This publication reports a decision by the Supreme Court (Højesteret) of Denmark, 22 juni 2012 in case 210/2011 (1. afd.). Dregg v. Chr. Jensen Shipping. Published in Danish: Ugeskrift for Retsvæsen 2012 p. 3001 et seq. The decision relates to the U.N. Model Arbitration Law and the author of the ...... author of the present Communication has been appointed by the Danish Ministry of Justice as the UNCITRAL National Correspondent for Denmark....

  11. Réaction du polyisobutène chloré sur l'anhydride maléique : mécanisme. Catalyse par l'anhydride dichloromaléique Reaction of Chlorinated Polyisobutene on Maleic Anhydride. Mechanism. Catalysis by Dichloromaleic Anhydride

    Directory of Open Access Journals (Sweden)

    Sillion B.

    2006-11-01

    Full Text Available Dans cet article le mécanisme de la réaction de condensation du polyisobutène chloré sur l'anhydride maléique, qui sert dans la synthèse d'additif pour lubrifiant, est étudié par une cinétique globale et par un travail sur composés modèles. Il est montré que, dans cette réaction, l'anhydride maléique joue un double rôle : de catalyseur de déshydrochloration par une réactivité de type acide de Lewis organique, de réactif comme diénophile. Grâce à ces résultats, il est proposé une catalyse par l'anhydride dichloromaléique, qui permet une amélioration sensible du procédé. This article examines the mechanism of the chlorinated-polyisobutene condensation reaction on maleic anhydride. The overall kinetics and model compounds are investigated for this reaction which is used in the synthesis of lubricant additives. Maleic anhydride is shown to play the dual role of a dehydrochlorination catalyst by having a reactivity of the organic Lewis acid type and of a reactant like dienophile. These results are used to propose a catalysis by dichloromaleic anhydride which appreciably improves the process.

  12. Malária e aspectos hematológicos em moradores da área de influência dos futuros reservatórios das hidrelétricas de Santo Antônio e Jirau, Rondônia, Brasil Malaria and hematological aspects among residents to be impacted by reservoirs for the Santo Antônio and Jirau Hydroelectric Power Stations, Rondônia State, Brazil

    OpenAIRE

    Tony Hiroshi Katsuragawa; Roberto Penna de Almeida Cunha; Daniele Cristina Apoluceno de Souza; Luiz Herman Soares Gil; Rafael Bastos Cruz; Alexandre de Almeida e Silva; Mauro Shugiro Tada; Luiz Hildebrando Pereira da Silva

    2009-01-01

    Em Rondônia, prevê-se a construção de mais duas usinas hidrelétricas (UHE) no rio Madeira, a montante da cidade de Porto Velho, Rondônia, Brasil (de Santo Antônio e Jirau). O objetivo deste trabalho foi analisar a prevalência da malária antes do início da implantação das obras civis e fazer considerações sobre os impactos da doença com o ingresso de milhares de trabalhadores e agregados atraídos pelas oportunidades de emprego e comércio. Os resultados obtidos mostram que a malária se faz pres...

  13. A ocorrência de malária em quatro municípios do estado do Pará, de 1988 a 2005, e sua relação com o desmatamento Occurrence of malaria in four cities in the state of Pará during 1988 to 2005 and its relationships with deforestation

    Directory of Open Access Journals (Sweden)

    Andressa Tavares Parente

    2012-03-01

    Full Text Available O objetivo deste trabalho foi estudar a ocorrência de malária em quatro diferentes regiões representativas do estado do Pará, buscando suas possíveis relações com as taxas de desmatamento. Foi realizado um estudo retrospectivo, com dados secundários, no período de 1988 a 2005, através de casos de malária registrados em quatro municípios do Estado (Anajás, Itaituba, Santana do Araguaia e Viseu, como também das taxas de desmatamento fornecidas pelo PRODES-INPE. Aplicou-se a técnica dos Quantis para se estabelecer cinco categorias ou classes de incidência da malária para cada município, sendo gerado posteriormente um IPA representativo para o Estado. De 1988 até 1994, as curvas de incidência de malária acompanham os números de desmatamento. A partir de 1995, evidenciaram-se anos consecutivos com altos índices de ocorrência da doença logo após os períodos de altas taxas de desmatamento, como registrado nos anos de 1995, 2000 e 2004. Percebeu-se que após a época de intenso desmatamento, os casos de malária variaram entre alto e muito alto no seu padrão de incidência, apontando que o desmatamento pode ser um fator de incremento na frequência e aumento no número de pessoas infectadas no estado do Pará.The purpose of this paper is to study occurrence of malaria in four different regions of the state of Pará and its possible relationships with deforestation rates. A retrospective study using secondary data from 1988 to 2005, using malaria incidence records reported in four cities in the state (Anajás, Itaituba, Santana do Araguaia and Viseu, as well as deforestation rates provided by the PRODES-INPE. The quantiles method was applied to establish five categories or classes of malaria incidence for each city, and a state IPA was generated with the contributions of these cities. From 1988 to 1994, the curves of incidence of malaria follow deforestation rates. From 1995, there are consecutive years of high incidence

  14. Spoločenstvá suchozemských mäkkýšov severnej časti Devínskej Kobyly (Malé Karpaty

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    Jozef Šteffek

    2005-11-01

    Full Text Available Present paper is focused on two topics. First topic is focused on evaluation of mollusc assemblages of northern part of the Devínska Kobyla hill (Malé Karpaty Mts.. The second topic was evaluation of all published data on molluscs of this area. The research was conducted during vegetation period of the year 1978. From 9 types of biotopes altogether 47 quantitative samples were sampled. The assemblages were evaluated on the base of constancy and dominance of the species. Altogether 7913 mollusc specimens were obtained from the samples. Composition and status of the forest mollusc assemblages in northern part of the Devínska Kobyla was shown to be determined by the substratum, age of forest stand and the degree of the biotopes disturbance. The species richest assemblage was detected within old grown forest (biotope 7 and calcareous substratum. The species poorest were assemblages found within clear-cut and young stand (biotopes 5, 8. Species rich community was found also in old growth forest with quartzite substratum, however a number of steppe species is absent within this biotope. The molluscan communities of open habitats were observed only in the northern part of the Devínska Kobyla foothill area. They occur mainly within xeric degraded grassland biotopes (vacant pastures, deforested fields. Within other non-limestone substratum biotopes only species poor coenoses composed of single or e few of species occurred (biotopes 2 and 6. The exception was the natural xeric grassland biotopes, which were typical biotopes for rich community of steppe molluscs (biotope 9. Extremely rich were limestone rocks, which are in addition partially covered by forest. The rich forest land snail community together with a number of xeric species was found here (biotope 3. In second part mollusc species composition of northern and southern part of the Devínska Kobyla massive and the Devínske Hradné Bralo hill are compared. Altogether 65 mollusc species (51

  15. Posição viciosa de cabeça por astigmatismo mal corrigido: relato de caso Abnormal head position caused by incorrect prescription for astigmatism: case report

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    Flávia Augusta Attié de Castro

    2005-10-01

    Full Text Available A posição viciosa de cabeça é uma condição compensatória que visa proporcionar aos pacientes melhor rendimento visual. Pode ser causada por problemas oftalmológicos, como distúrbios oculomotores (nistagmos, estrabismos e altos astigmatismos. No entanto, compromete a estética e, a longo prazo, pode causar transtornos ortopédicos (coluna cervical e assimetrias faciais. Relatamos o caso de uma garota, JL, 8 anos, com cabeça inclinada para esquerda havia vários anos. Fazia uso de óculos prescritos em outro serviço para correção de astigmatismo misto: OD= +2,00 DE Ç -5,50 DC a 180º e OE= +2,25 DE Ç -5,75 DC a 180º. No exame oftálmico, a paciente apresentava cabeça inclinada para a esquerda e acuidade visual com correção de 0,5 no OD e 0,7 OE. Os testes de cobertura simples e alternado não evidenciaram desvio ocular. Rotações oculares, biomicroscopia e fundoscopia também não mostraram alterações. Na refratometria sob cicloplegia e teste de lentes foram encontrados: OD= +3,50 DE Ç -6,00 DC a 10º e OE= +3,50 DE Ç -6,00 DC a 170º, com acuidade visual igual a 1,0 nos olhos direito e esquerdo. Foram prescritas as lentes encontradas no exame e a paciente retornou com a correção nova sem a inclinação de cabeça. Erros refracionais mal corrigidos também podem gerar torcicolo e, muitas vezes, passam despercebidos. Refratometria sob cicloplegia e teste de lentes são fundamentais para um diagnóstico preciso.Abnormal head position is a compensatory condition which improves patients' vision. It can be caused by ophthalmological problems such as oculomotor imbalances (strabismus, nystagmus and high astigmatisms. However, it results in esthetic impairment, orthopedic trouble and facial asymmetries. We describe a case of a girl, JL, 8 years, with abnormal head position tilted to the left since the last glasses were prescribed. The correction used by the patient was: right eye = +2.00 sph à -5.5 cyl 180° and left eye = +2

  16. Controle da transmissão da malária em área de garimpo no Estado do Amapá com participação da iniciativa privada Control of malaria transmission in a gold-mining area in Amapá State, Brazil, with participation by private enterprise

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    Álvaro Augusto Couto

    2001-08-01

    Full Text Available Reportamos no presente trabalho a caracterização epidemiológica da malária, seguida da implantação de um programa de controle da endemia em uma área de garimpo, localizada ao norte do estado do Amapá. Considera-se a influência desta região no número total de casos do estado e o impacto da doença na população representada pelos funcionários e empreiteiros da Mineração Novo Astro S/A, bem como pela comunidade da Vila de Lourenço, Município de Calçoene, Amapá e garimpos adjacentes. O impacto das ações de controle adotadas no âmbito do programa, caracterizam-se pela significativa redução da incidência da malária na área e a redução da morbi-mortalidade. Ressalta-se a importância da participação da iniciativa privada, principalmente aquelas que desenvolvem projetos de grande porte na região Amazônica brasileira, no controle das endemias prevalentes na região, particularmente a malária.This paper reports on the epidemiological characterization of malaria following implementation of a program to control the endemic in a gold-mining area in northern Amapá State. The study focuses on total malaria cases in Amapá and the impact of the disease on the population, as represented by the Mineração Novo Astro S/A company and its employees as well as the community of Vila de Lourenço in the municipality of Calçoene, and adjacent gold miners. The effect of control measures in the program area is indicated by a significant reduction in malaria incidence and malaria-related morbidity and mortality. The importance of participation by private enterprise is emphasized, particularly in large projects for the control of endemic diseases (notably malaria in the Amazon Region.

  17. Malófagos (Phthiraptera recolhidos de aves silvestres no Zoológico de São Paulo, SP, Brasil Chewing lice (Phthiraptera from wild birds in the São Paulo Zoo, State of São Paulo, SP, Brazil

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    Michel P. Valim

    2005-12-01

    Full Text Available Vinte e oito espécies de malófagos foram recolhidas de aves silvestres no acervo do Zoológico de São Paulo durante o ano de 2003. Vinte e três foram identificadas ao nível de espécie e cinco ao nível genérico. Os relatos de novas espécies no Brasil e novas associações parasitárias para a literatura são discutidos.Twenty-eight species of chewing lice were recovered from wild birds in the São Paulo Zoo during 2003. Twenty-three were identified to species level and five to the generic level. New species records for Brazil and new host-lice associations are discussed.

  18. A utilização de uma rede neural artificial para previsão da incidência da malária no município de Cantá, estado de Roraima Use of an artificial neural network to predict the incidence of malaria in the city of Cantá, state of Roraima

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    Guilherme Bernardino da Cunha

    2010-10-01

    Full Text Available INTRODUÇÃO: A malária é uma doença endêmica na Amazônia Legal Brasileira, apresentando riscos diferentes para cada região. O Município de Cantá, no Estado de Roraima, apresentou para todo o período estudado, um dos maiores índices parasitários anuais do Brasil, com valor sempre maior que 50. O presente estudo visa à utilização de uma rede neural artificial para previsão da incidência da malária nesse município, a fim de auxiliar os coordenadores de saúde no planejamento e gestão dos recursos. MÉTODOS: Os dados foram coletados no site do Ministério da Saúde, SIVEP - Malária entre 2003 e 2009. Estruturou-se uma rede neural artificial com três neurônios na camada de entrada, duas camadas intermediárias e uma camada de saída com um neurônio. A função de ativação foi à sigmoide. No treinamento, utilizou-se o método backpropagation, com taxa de aprendizado de 0,05 e momentum 0,01. O critério de parada foi atingir 20.000 ciclos ou uma meta de 0,001. Os dados de 2003 a 2008 foram utilizados para treinamento e validação. Comparam-se os resultados com os de um modelo de regressão logística. RESULTADOS: Os resultados para todos os períodos previstos mostraram-se que as redes neurais artificiais obtiveram um menor erro quadrático médio e erro absoluto quando comparado com o modelo de regressão para o ano de 2009. CONCLUSÕES: A rede neural artificial se mostrou adequada para um sistema de previsão de malária no município estudado, determinando com pequenos erros absolutos os valores preditivos, quando comparados ao modelo de regressão logística e aos valores reais.INTRODUCTION: Malaria is endemic in the Brazilian Amazon region, with different risks for each region. The City of Cantá, State of Roraima, presented one of the largest annual parasite indices in Brazil for the entire study period, with a value always greater than 50. The present study aimed to use an artificial neural network to predict the

  19. Caracterização das epidemias de malária nos municípios da Amazônia Brasileira em 2010 Caracterización de las epidemias de malaria en los municipios de la Amazonia brasileña en 2010 Characteristics of malaria epidemics in the municipalities of the Brazilian Amazon, 2010

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    Pedro Luiz Tauil

    2013-05-01

    Full Text Available Epidemias de malária ocorrem anualmente nos municípios da Região Amazônica, Brasil, no entanto os serviços de saúde não adotam, de maneira sistemática, instrumentos para detecção e contenção oportunas desses eventos. O objetivo foi caracterizar as epidemias de malária na região segundo duração, espécie de Plasmodium e vulnerabilidade das populações. Foi avaliado um sistema de monitoramento automatizado da incidência da malária, com base no diagrama de controle segundo quartis, para identificar as epidemias da doença. Em 2010, ocorreram epidemias em 338 (41,9% municípios da região. Houve epidemias por P. falciparum e por P. vivax, separadamente, e também por ambas as espécies. Epidemias com duração de um a quatro meses ocorreram em 58,3% dos municípios epidêmicos; de cinco a oito meses, em 24,3%; e de nove a 12 meses, em 17,4%. O monitoramento automatizado da variação da incidência da malária poderá contribuir para detecção precoce das epidemias e melhorar o seu controle oportuno.Las epidemias de malaria ocurren anualmente en los municipios de la Región Amazónica, Brasil, no obstante, los servicios de salud no adoptan de manera sistemática instrumentos para la detección y contención oportuna de este tipo de eventos. El objetivo fue caracterizar las epidemias de malaria en la región según su duración, especie de Plasmodium y vulnerabilidad de las poblaciones. Se evalúo un sistema de supervisión automatizado de la incidencia de la malaria, en base al diagrama de control según cuartiles, con el fin de identificar las epidemias de la enfermedad. En 2010, se produjeron epidemias en 338 (41,9% municipios de la región. Hubo epidemias por P. falciparum y por P. vivax, separadamente, y también por ambas especies. Hubo epidemias con una duración de uno a cuatro meses que se produjeron en un 58,3% de los municipios epidémicos; de cinco a ocho meses, en un 24,3%; y de nueve a 12 meses, en un 17,4%. La

  20. Analysis on a Mal-operation of Differential Protection for Ultra-high Voltage Transformer and Its Countermeasure%一起特高压变压器的差动保护误动分析及防范措施

    Institute of Scientific and Technical Information of China (English)

    郑涛; 张婕; 高旭

    2011-01-01

    通过建立MATLAB仿真模型,分析了在特高压交流试验示范工程投运调试过程中出现的一起由于中压侧空投主变压器产生励磁涌流而导致调压变压器差动保护误动作的案例。针对特高压变压器结构上的特殊性,分析了合闸角、剩磁等因素对励磁涌流的影响,仿真复现了现场故障录波波形。针对调压变压器差动电流中二次谐波含量较低可能引起的误动,从2个方面提出了相应的解决方案:指出二次谐波涌流闭锁判据宜采用三取二闭锁方式,但在某些特殊情况下,依然可能失效,进而提出了利用二次谐波变化趋势来识别励磁涌流和故障电流的辅助判据,并对综合判据进行了仿真验证;分析了调压变压器容量对励磁涌流的影响,提出在条件允许的情况下,适当增加调压变压器容量来避免励磁涌流可能引起的误动,为提高调压变压器差动保护可靠性提供了新思路。%A simulation model based on MATLAB is developed to analyze the mal-operation of differential protection in voltage regulating transformer(VRT) in an experiment project of ultra-high voltage system,which is caused by inrush current during energizing of the transformer from medium-voltage side.According to particular structure of ultra-high voltage transformers,the influence of closure angle and residual magnetism,etc.on inrush current is analyzed and the waveform of field failure is resembled with simulation.In order to solve mal-operation caused by less second harmonic in differential current of VRT,lock criteria for second harmonic of inrush current should adopt two-out-of-three principle,but it may not valid in some situation.Furthermore,auxiliary criteria with second harmonic tendency is proposed for identifying inrush current or faulty current.Besides,it analyzes the influence of VRT capacity on inrush current and also suggests that suitably increasing the capacity of VRT should be considered in

  1. [Cu(bpy)(H2O)(mal)]·H2O配合物的拓扑结构及磁性研究%Syntheses, characterization and magnetic property of copper with malonic acid and 2,2'-bipyridine complex

    Institute of Scientific and Technical Information of China (English)

    金陵; 朱红林

    2013-01-01

    The title compound [ Cu ( bpy ) { H2O ) ( mal) ] · H2O(bpy =2,2'-Bipyridine,mal = malonic acid) was synthesized in water-methanol solution. The crystal structure was determined by single-crystal x-ray diffraction analysis. The crystal belongs to triclinic with space group P-1 ,a = 7. 132( 1)A, 6 = 10. 404 (2) A,c = 10. 694 (2) A, a = 105. 85 (3)°,β = 104.53(3)°, r = 105. 28 (3 ) °, V = 690.4 (2) (A3),DC = 1.721 g ·cm-3 ,Z = 2. In the title complex,the Cu( II ) ion is five-coordinated, forming a square pyramidal CuN2O, coordination environment. The complex was characterized by IR spectrum, Elemental analysis, X-ray powder diffraction, thermal analysis, magnetic property. The 3D topology analysis of the title compound showed an uncommon 4,6-connected bi-nodal fsc topology. The complex is ferromagnetic and obeys Curie-Weiss law with Xm ( T - 0. 27) = 0. 85 cm3 · K · mol-1 between 2 ~ 300 K (Xm being magnetic susceptibility per one Cu2+ ion).%应用溶液法合成标题配合物[Cu(bpy)(H2O) (mal)]·H2O(bpy=2,2'-联吡啶,mal=丙二酸).通过X射线衍射法测定配合物的晶体结构,其晶体学数据如下:三斜,P-1,a=7.132(1)(A),b=10.404(2)(A),c=10.694(2)(A);α=105.85(3)°,β=104.53(3)°,γ=105.28(3)°,V=690.4(2)((A)3),Dc=1.721 g·cm-3,Z=2.在标题化合物中,中心Cu(Ⅱ)离子配位数为5,构成CuN2O3四方锥配位模式.并对其进行红外光谱、元素分析、粉末X射线衍射、差热、磁性等表征.配合物的3D拓扑分析可简化含有(4,6)-双节点fsc拓扑网络,配合物在2~300 K区间遵循韦斯定理xm(T-0.27)=0.85 cm3·K·mol-1,磁性测试结果表明Cu2+离子之间存在铁磁作用.

  2. Compensatory growth of Malaysian prawns reared at high densities during the nursery phase Crescimento compensatório em camarões-da-malásia cultivados sob altas densidades durante a fase de berçário

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    H.L.A. Marques

    2011-04-01

    Full Text Available The objective of this work was to verify the occurrence of compensatory growth in Malaysian prawn (Macrobrachium rosenbergii reared in pens, after being stocked in cages under high densities during nursery phase. The experiment was carried out in 0.5 m² cages and 2-m² pens set in natural bottom pond with 2,400 m². Prawn post-larvae (PL with an average weight of 0.026 ± 0.012 g (nursery phase were initially stocked in 16 cages at the densities of 50, 400, 800 and 1,200 PL m-2. Sixty days later, prawns were transferred to 16 growing pens, at the density of 12 prawns m-2. Initial average weight of the prawn in this phase was the final average weight registered in the nursery phase, as follows: 50 PL m-2 = 2.3 ± 0.3 g; 400 PL m-2 = 0.5 ± 0.03 g; 800 PL m-2 = 0.3 ± 0.05 g and 1,200 PL m-2 = 0.1 ± 0.01 g. Commercial rations for prawns (35% crude protein were given once a day, in the afternoon. After 244 days, survival, average weight and biomass did not differ significantly among prawns with different initial average weight. Relative growth rate was significantly greater in prawns previously stocked at 1,200 PL m-2 and feed conversion efficiency was significantly better for those previously stocked at 400 and 1,200 PL m-2. These results suggest the existence of partial compensatory growth in M. rosenbergii, what can successfully carry on stocking of prawns of this species at high densities in the nursery phase.Este trabalho foi realizado com o objetivo de verificar a ocorrência de crescimento compensatório em camarões-da-malásia (Macrobrachium rosenbergii cultivados em cercados, após serem estocados em gaiolas sob altas densidades durante a fase de berçário. O experimento foi conduzido em gaiolas com 0,5 m² e cercados com 2 m² instalados em um viveiro de fundo natural com 2.400 m². Pós-larvas (PL de camarões com peso médio de 0,026 ± 0,012 g (fase de berçário foram inicialmente estocadas em 16 gaiolas, nas densidades de 50, 400

  3. Criaturas bien nacidas aunque mal habidas y bien habidas aunque mal nutridas.

    OpenAIRE

    Grajales, Agustín

    2008-01-01

    Sur la base de 12 396 actes de baptême des fils légitimes, naturels et abandonnés de la paroisse de El Sagrario de la cathédrale de la ville de Puebla au cours de la décennie qui va de 1783 a 1792, on analyse les taux d'ilégitimité par groupe éthnique (entre huit et vingt pour cent) ainsi que le phénomène de l'abandon d'enfants. Celui-ci est effectué au seuil des portes et dans une moindre mesure dans l'hôpital d'enfants abandonnés dont on mentionne son origine et couverture. L'étude aborde l...

  4. Arterite de Takayasu com estenose de artéria renal diagnosticada em paciente com 65 anos de idade

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    Ellen Simionato Valente

    2015-12-01

    Full Text Available Resumo Arterite de Takayasu é uma doença rara, de etiologia desconhecida, que acomete a aorta e seus principais ramos. É uma patologia, geograficamente mais comum no Sudeste Asiático, que acomete principalmente mulheres em idade reprodutiva. A apresentação clínica é inespecífica, com sinais e sintomas que variam de acordo com o seguimento arterial acometido. O vaso mais comumente afetado é a artéria subclávia, enquanto a estenose de artéria renal é relativamente incomum. Comprometimento cardíaco e associação com outras patologias também podem estar presentes. Apresentamos neste relato o caso de uma paciente idosa com diagnóstico tardio de arterite de Takayasu e várias comorbidades ou complicações relacionadas.

  5. Hiperplasia Prostática Benigna e PSA: o efeito dominó Benign prostatic hyperplasia and PSA: the domino effect Hiperplasia benigna de prostata y PSA: el efecto dominó

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    José Agostinho Santos

    2012-12-01

    Full Text Available

    Após a publicação de uma recomendação contra o rastreio câncer prostático pela U.S. Preventive Services Task Force, a comunidade médica não poderá desvincular-se das particularidades relacionadas com o antígeno prostático específico (PSA. O enfoque dado às guidelines da Hiperplasia Prostática surge pela possível partilha, a determinado ponto da sua abordagem, de um trilho que cursa também com a solicitação do PSA. Os resultados de dois grandes ensaios clínicos constituem o maior corpo da evidência actual e deles sobressai que o número de homens que evitaram a morte por câncer prostático após submetidos ao rastreio foi reduzido. Há evidência de que 100-200 em 1000 homens rastreados terão um falso-positivo, a maioria dos quais será biopsada, com possíveis danos psicológicos e orgânicos. O Médico de Família deverá relembrar que não é recomendado que se ofereça esta análise, sem que primeiro discuta, juntamente com o paciente, as questões inerentes ao PSA.

    After U.S. Preventive Services Task Force published a recommendation against prostate cancer screening, the medical community cannot extricate itself from all specific features associated with the prostate-specific antigen (PSA. The focus given to the guidelines of the Prostatic Hyperplasia happens for the possible sharing of a certain point of its approach with the prostatic cancer case-finding, that is the PSA test. The results of two large clinical trials represent the largest body of evidence and they say the number of men who avoided prostate cancer death after subjected to screening was reduced. There is evidence that 100-200 in 1000 screened men will have a false-positive, most of which will have a biopsy with possible psychological damage and organic. The GP should remember that it is not recommended to provide this test, without first discussing together with the patient, the issues that are inherent to the PSA sample.

    Después de U.S. Preventive Services Task Force publicar una recomendación en contra el screening del cáncer de próstata, la comunidad médica no puede liberarse de todas las particularidades propias de lo antígeno prostático específico (PSA. La atención prestada a las directrices de la Hiperplasia Prostática aparece debido a posibilidad de compartir un cierto punto com el screening, que conduce a la petición del PSA. Los resultados de dos grandes ensayos clínicos representan el mayor cuerpo de evidencia y de ellos sobresale que el número de hombres que evitaron la muerte de cáncer de próstata después de someterse a el screening es reducido. Hay evidencia de que 100-200 en 1000 hombres sometidos a el screening tendrá un falso positivo, mayoría de los cuales será biopsada con posible daño psicológico y orgánico. El médico de família debe recordar que no se recomienda para proporcionar este estudio analítico, sin discutir primero junto con el paciente, los problemas que son inherentes en el PSA.

  6. Hiperplasia Prostática Benigna e PSA: o efeito dominó Benign prostatic hyperplasia and PSA: the domino effect Hiperplasia benigna de prostata y PSA: el efecto dominó

    OpenAIRE

    José Agostinho Santos

    2012-01-01

    Após a publicação de uma recomendação contra o rastreio câncer prostático pela U.S. Preventive Services Task Force, a comunidade médica não poderá desvincular-se das particularidades relacionadas com o antígeno prostático específico (PSA). O enfoque dado às guidelines da Hiperplasia Prostática surge pela possível partilha, a determinado ponto da sua abordagem, de um trilho que cursa também com a solicitação ...

  7. Expansão urbana e distribuição espacial da malária no município de Manaus, Estado do Amazonas Urban expansion and spatial distribution of malaria in the municipality of Manaus, State of Amazonas

    Directory of Open Access Journals (Sweden)

    Maria das Graças Gomes Saraiva

    2009-10-01

    Full Text Available No município de Manaus, a intensificação do processo migratório, aliada a precária vigilância epidemiológica e entomológica, resultou na reintrodução da transmissão de malária no perímetro urbano, zona Leste, em julho de 1988, após 13 anos sem registro de autoctonia. Este estudo descreve sobre a situação epidemiológica da malária e áreas que sofreram ações antrópicas (desmatamento, assentamentos humanos, atividades de piscicultura, etc. em Manaus, no período entre 1986 e 2005. Nesse Município, o incremento populacional em 2005 atingiu 105,2%, em relação a 1986, resultado de ocupação dos espaços (invasões e conjuntos habitacionais. A partir de 2003, a doença teve incremento acima 2.000% em relação a 1986. Nessas áreas ocorreu aumento da incidência da doença. O índice parasitário anual no Município oscilou de baixo a médio risco, e entre as zonas urbanas, variou de sem risco a alto risco. As zonas Leste, Oeste e Norte onde ainda existem áreas com características rurais apresentaram maior receptividade e vulnerabilidade de transmissão.In the municipality of Manaus, intensification of the migratory process, along with precarious epidemiological and entomological surveillance, resulted in reintroduction of malaria transmission on the urban perimeter (in the eastern zone, in July 1988, after 13 years without any records of autochthonous disease. This study reports on the epidemiological situation relating to malaria and to the areas that were subjected to human actions (deforestation, human settlement, fish-rearing activity, etc in Manaus, between 1986 and 2005. In this municipality, the population increase from 1986 to 2005 was 105.2%. This resulted from occupation of space, in the form of invasions and housing projects. From 2003, the increase in relation to 1986 was more than 2,000%. In these areas, there were increases in disease incidence. The annual parasitic index in the municipality ranged from low to

  8. Benign monomelic amyotrophy: a study of twenty-one cases Amiotrofia monomélica benigna: estudo de 21 casos

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    MARCOS R.G. DE FREITAS

    2000-09-01

    Full Text Available A consecutive series of 21 patients with single limb atrophy (monomelic amyotrophy is reported. Sixteen had lower limb atrophy and five had upper limb involvement. The median age of the onset was 20 years. Characteristic features were sporadic occurrence, wasting confined to one limb, insidious onset with slow progression, stabilizing in 1 to 4 years, and absence of pyramidal signs. All the patients with upper limb involvement were male, however in our cases with lower limb amyotrophy there were no male preponderance. We observed wasting of the entire length of the lower limbs in six patients. There were nine cases with amyotrophy restricted to the leg and one with amyotrophy only in the thigh. In the upper limb in four cases the involvement was distal and in one patient the atrophy was proximal. The electromyographic features were suggestive of anterior horn disease not only in the affected limb but also, in some cases, in clinically uninvolved limb. Cervical or lumbar MRI was normal. MRI of the lower limb disclosed increased signal intensity in the gastrocnemius and soleus muscles in one patient suggesting denervation.Relatamos uma série consecutiva de 21 pacientes com amiotrofia de um só membro, denominada de amiotrofia monomélica. Em 16 casos a atrofia era no membro inferior e em 5 localizava-se no membro superior. Todos eram jovens e a idade média do início foi 20 anos. Os dados mais característicos da doença foram ausência de história familiar, comprometimento de um só membro, início e progressão lenta estabilizando em até 4 anos e ausência de sinais piramidais. Nossos enfermos com amiotrofia de membro superior eram todos do sexo masculino, entretanto naqueles com amiotrofia do membro inferior havia igualdade de sexos. Dos pacientes com atrofia de membro inferior, em 9 a atrofia era restrita a perna, em 6 era em todo o membro e somente um apresentava amiotrofia localizada só na coxa. Naqueles com comprometimento do membro superior a atrofia era distal em 4 e proximal em 1. Os achados na eletromiografia foram compatíveis com acometimento do II neurônio motor. Todos foram submetidos a RM da coluna cervical ou lombar que se mostrou normal. Em um caso realizamos RM da perna acometida que evidenciou sinais hiperintensos nos músculos gastrocnemius e soleus, o que sugere desnervação.

  9. Blacasset, “Se·l mals d’amor m’auzi ni m’es noisens” (BdT 96.10a; Pujol, “Dieus es amors e verais salvamens” (BdT 386.2; Alaisina ~ Carenza, “Na Carenza al bel cors avenenç” (BdT 12.1 = 108.1

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    Paolo Di Luca

    2012-09-01

    Full Text Available This paper provides a new critical edition of “Se·l mals d’amor m’auzi ni m’es noisens” by Blacasset and “Dieus es amors e verais salvamens by Pujol”. These two poets discuss a topic that is entirely new to Occitan lyric poetry: two young women about to enter a convent. While Blacasset expresses sadness about their choice of life in a convent, using elements of the funeral lament, Pujol praises it and believes it to be the only remedy for the corruption of the world. The tenso between women “Na Carenza al bel cors avenenç” seems to be conceived as a parody of this lyric debate: in the dialogue Alaisina and Yselda, who have doubts about becoming mothers, ask Na Carenza whether it is better to stay virgins or to marry; the latter advises them, in cryptic terms that are difficult to interpret, to become nuns, thereby gaining a husband (God but not children. I will suggest that the question of female authorship for this text be reconsidered, while proposing a new interpretation in the light of the lively debate in the medieval period about the suitability and prerogatives of virginity.

  10. Análise da freqüência de recaídas de malária por Plasmodium vivax em região não endêmica (São Paulo, Brasil Analysis of the frequency of relapses due to malaria caused by Plasmodium vivax in a non endemie area (São Paulo, Brazil

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    Marcos Boulos

    1991-04-01

    Full Text Available Em virtude da existência de poucas informações, devidamente registradas, sobre freqüência e épocas de recaídas de malária por Plasmodium vivax, contraída no Brasil, foi analisada casuística observada em região não endêmica e constituída por pacientes corretamente tratados. O índice de recaídas documentadas em São Paulo, foi alto (24,5%, com desenvolvimento precoce na maioria das oportunidades, ou seja, em tempo inferior a três meses.Very few well-established information is available about the frequency and timeliness of relapses in cases of Plasmodium vivax malaria acquired in Brazil. So, we analysed a series of correctly treated patients observed out of endemic areas. The rate of relapses seen in São Paulo, which may represent that of the parasitosis in the whole country, was high, ranging from 7.5% to 24.5%, and early in most cases, i.e. appearing by three months, what anticipates a high endemicity.

  11. Anopheline species, some of their habits and relation to malaria in endemic areas of Rondônia State, Amazon region of Brazil Espécies de anofelinos, alguns de seus hábitos e relação com a malária, em áreas endênmicas do Estado de Rondônia, Amazônia brasileira

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    Ricardo Lourenço-de-Oliveira

    1989-12-01

    Full Text Available In view of recent studies incriminating several species of anophelines, besides Anopheles darlingi, as malaria vectors in the Brazilian Amazon, we performed an anopheline survey in four localities - Ariquemes, Cujubim, Machadinho and Itapoã do Oeste - in Rondônia, the most malarious State in the Country. Twenty species were found. An. darlingi was, by far, the dominant species and the only one whose density coincided with that of malaria. On human baits it was more numerous in the immediate vincinity of houses than indoors whre, however, it was almost the only species encountered. On both situations it fed mostly at sunset and during the first half of the night. It was less numerous far from houses and scarce inside the forest. Other species (An. triannulatus, An. evansae, An. albitarsis, An. strodei appeared in appreciable numbers only in Ariquemes, both in areas with and without malaria. The remaining species were scanty. An. darlingi was confirmed as the primary local vector.Como recentes estudos vêm incriminando diversas espécies de anofelinos como trasnmissores da malária na Amazônia brasileira além do Anopheles darlingi, realizamos um estudo sobre esse grupo de mosquitos em quatro localidades - Ariquemes, Cujubim, Machadinho e Itapoã do Oeste - no Estado de Rondônia, o mais malarígeno do país. Vinte espécies foram achadas. An. darlingi foi, de longe, a predominante e a única cuja densidade coincidiu com a da malária. Sugando iscas humanas, esse mosquito mostrou-se mais numeroso na imediata vizinhança das casas que em seu interior, onde, entretanto, foi quase a única espécie encontrada. Em ambas as situações picava principalmente ao crepúsculo vespertino e durante a primeira metade da noite, sendo menos freqüente longe das casas e escasso na floresta. Outras espécies, como An. triannulatus, An. evansae, An. albirarsis e An. strodei foram capturadas em números apreciáveis, somente em Ariquemes, em áreas com e sem mal

  12. Antropometria e perfil lipídico em mulheres com câncer de mama: um estudo caso-controle

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    Karine Anusca Martins; Ruffo Freitas-Junior; Estelamaris Tronco Monego; Régis Resende Paulinelli

    2012-01-01

    OBJETIVO: avaliar a composição corporal e o perfil lipídico de mulheres com e sem câncer de mama. MÉTODOS: estudo caso-controle pareado por idade, incluindo 62 mulheres, sendo 31 recém-diagnosticadas com câncer de mama e 31 com alterações mamárias benignas. Os dados foram coletados por meio de entrevista direta, com caracterização sociodemográfica, avaliação da composição corporal por antropometria, incluindo dobras cutâneas (DC) e circunferências, bioimpedância (BIA) e ultrassonografia (USG)...

  13. Aspectos da transmissão focal de malária na Ilha de São Luis, Maranhão Aspects of the focal transmission of malaria in the Island of São Luis, Maranhão

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    Antônio Rafael da Silva

    2006-06-01

    Full Text Available O estudo foi desenvolvido com o objetivo de caracterizar um foco de transmissão de malária em Guarapiranga, município de São José de Ribamar, MA. A unidade de estudo foi o grupo familiar, aplicando-se questionário sobre identificação, situação econômica, hábitos dos moradores e características dos domicílios. Foram visitadas 54 famílias, totalizando 207 habitantes, sendo 113 do sexo masculino e 95, do feminino. 95 pessoas tinham de 5 a 24 anos. Agricultura e pesca são a base da economia local, com 64,8% das famílias auferindo renda mensal menor que um salário mínimo. A maioria das casas é construída de taipa, coberta de palha, tem piso de chão batido e não tem instalações sanitárias. Em relação à entrada de mosquitos, 62,2% são parcialmente protegidas. A água para consumo provém de cacimbas ou poços rasos em 78,8%, e o lixo é deixado a céu aberto em 53,7% dos domicílios. Foram registrados 106 casos de malária por Plasmodium vivax. O provável transmissor foi o Anopheles (N aquasalis e o tratamento com cloroquina associado à primaquina teve bons resultados.The aim of the study was to typify a malaria focus in Guarapiranga, in the district of São José de Ribamar, MA. A questionnaire regarding identification, economic situation, habits of the residents and characteristic of the residences was applied to each family. Fifty four families were visited and 207 inhabitants were interviewed (113 men and 95 women; 95 individuals were aged between 5 and 24 years old. Agriculture and fishing are the basis of the local economy; 64.8% of the families earn less than one living wage. The majority of the residences are constructed of mud walls, straw roofs, a beaten earth floor, with no basic sanitation. 62.2% of the residences are partially protected against the entry of mosquitoes. Water for domestic use comes from natural waterholes in 78.8% of the residences. Rubbish is left in the open air in 53.7% of the residences

  14. Uso do sensoriamento remoto para estudar a influência de alterações ambientais na distribuição da malária na Amazônia brasileira Use of remote sensing to study the influence of environmental changes on malaria distribution in the Brazilian Amazon

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    Cíntia Honório Vasconcelos

    2006-03-01

    Full Text Available A construção da hidroelétrica de Tucuruí, no sudeste do Estado do Pará, Brasil, em 1981, impôs grandes mudanças ambientais, desmatamentos e migração para a região. O objetivo deste trabalho é verificar a influência destas mudanças na ocorrência da malária no Município de Jacundá, Pará, Brasil, utilizando-se técnicas de sensoriamento remoto e sistemas de informações geográficas. Os parâmetros utilizados para a construção dos mapas foram: distância das estradas, classe agrossilvopastoril, distância de coleções hídricas (rios, igarapés e do reservatório e da área urbana do município. Neste estudo, verificou-se o caráter epidêmico da malária a partir da construção da barragem de Tucuruí. Sugere-se que o padrão sazonal da incidência está relacionado com o período de maior estabilidade das margens do reservatório e ocorrência de áreas alagadas, além de maior exposição de trabalhadores na época de colheita na região. Foi observado que a distribuição dos casos está relacionada com as formas de uso e ocupação da terra, principalmente em áreas de maior influência das estradas, locais onde se concentra grande parte da população.Construction of the Tucuruí hydroelectric dam in Southeast Pará State, Brazil, in 1981, caused enormous environmental changes, deforestation, and human migration to the region. This study focuses on the influence of these changes and the appearance of malaria in the municipality of Jacundá, Pará, using remote sensing and geographic information systems. The variables used to construct maps were distances from roads, farming areas, rivers, the dam, streams, and the urban area. This study confirmed the elevation of malaria to the epidemic level since the construction of the Tucuruí dam. The study suggests that a seasonal pattern of malaria incidence is associated with the flooding season and exposure of workers during harvest. Malaria cases were related to the form of

  15. Spatial analysis for stratification of priority malaria control areas, Mato Grosso State, Brazil Análise espacial na estratificação de áreas prioritárias para o controle da malária no Estado de Mato Grosso, Brasil

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    Marina Atanaka-Santos

    2007-05-01

    Full Text Available The goal of this study was to stratify priority areas for malaria control in the State of Mato Grosso, Brazil, based on spatial analysis. The variables used were: Annual Parasite Index (API, Plasmodium falciparum/Plasmodium vivax ratio, population variation, number of families settled, and percent of deforested area. The Moran's I and Local Moran Test were applied, visualized with the Box Map and Moran Map, for 1986- 1991, 1992-1997, and 1998-2003. Box Map identified areas with high, low, and intermediate priority for control, and Moran Map identified municipalities with significant autocorrelation. In the high priority area, located in the North of Mato Grosso, malaria incidence decreased drastically despite the increase in the number of municipalities from the first to the last period. Other municipalities were added to the lower priority area, from the Southeast, Southwest, and Central-South of the State. The intermediate priority area was located along the border with neighboring States and municipalities classified as high and low priority. Spatial analysis showed the importance of the neighboring phenomenon between municipalities in defining priority areas, thus highlighting the technique's advantages for use in malaria control and surveillance.Pautado em técnicas de análise espacial, analisou-se a estratificação de áreas prioritárias para controle da malária no Estado de Mato Grosso, Brasil. Trabalhou-se Incidência Parasitária Anual, relação Plasmodium falciparum/Plasmodium vivax, variação populacional, número de famílias assentadas e percentuais da área desmatada. Foram utilizados os testes de I de Moran e Moran Local, visualizadas pelo Box Map e Moran Map, nos períodos de: 1986 a 1991, 1992 a 1997 e 1998 a 2003. Pelo Box Map identificaram-se áreas de prioridade maior, menor e intermediária, e pelo Moran Map localizaram-se municípios com autocorrelação estatisticamente significante. Na área de maior prioridade

  16. Conhecimentos, práticas e percepções de profissionais de saúde sobre o tratamento de malária não complicada em municípios de alto risco da Amazônia Legal Uncomplicated malaria treatment in the Brazilian Amazon: knowledge, practices and perceptions of health workers in high-incidence municipalities

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    Claudia Garcia Serpa Osorio-de-Castro

    2011-01-01

    Full Text Available O controle da malária no Brasil conta com diagnóstico precoce e tratamento adequado e oportuno como estratégia para cura rápida e duradoura. Consequências clínicas e resistência aos antimaláricos podem resultar de falhas na prescrição, dispensação e aceitação dos profissionais aos esquemas terapêuticos propostos. Objetivou-se avaliar conhecimentos, práticas, percepções e atitudes de profissionais envolvidos na assistência farmacêutica à malária, frente ao protocolo oficial e a possíveis falhas na terapêutica. Entrevistaram-se profissionais em seis municípios na Amazônia Legal. Utilizou-se técnica de análise do discurso para determinação de categorias analíticas e sistematização. Dos 63 entrevistados, houve apenas um médico. Os demais, de nível médio, atuavam no diagnóstico, indicação e dispensação do tratamento antimalárico. O tempo de formação e de treinamento foi variável. Houve falhas na adesão ao protocolo nacional, perpassando indicação, dispensação e orientação aos pacientes. Os profissionais carecem de conhecimento para lidar com as especificidades da doença e do tratamento. A responsabilização de profissionais que não possuem o preparo necessário para a atenção sugere necessidade de políticas para a adequada capacitação e incorporação de recursos humanos.Malaria control in Brazil is based on early diagnosis and adequate and timely treatment as strategies for a rapid and long-lasting cure. Clinical consequences and resistance to antimalarials may arise from problems in prescribing, dispensing and in acceptance of therapeutic regimens by healthcare workers. We studied knowledge and practices, perceptions and attitudes of health workers participating in pharmaceutical services for malaria, regarding the official protocol and the possible flaws in therapy. Health workers from six municipalities in the Brazilian Amazon were interviewed. Speech analysis was employed as a technique

  17. Estudo sobre a eventual utilidade de raios gama na profilaxia da malária transmissível por transfusão de sangue A study on the fortuitons advantage of gamma irradiation in the prophylaxis of transmissible malaria by blood transfusion

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    Lúcia Maria Almeida Braz

    1998-12-01

    Full Text Available O estudo foi realizado com o objetivo de avaliar a eventual utilidade de raios gama na profilaxia da malária transmissível por transfusão de sangue, tendo sido, para isso, usados camundongos infectados pelo Plasmodium berghei. Na primeira fase, quando submetemos sangue deles retirado a 2.500 e 5.000rad, com associação ou não de metronidazol, não obtivemos sucesso, já que todos os animais antes sem a parasitose apresentaram parasitemia e morreram após inoculação do sangue irradiado. Porém, ocorreu êxito parcial na segunda fase, ao serem empregados 10.000 e 15.000rad, porquanto 20% e 40% dos roedores, respectivamente, embora tenham ficado infectados, sobreviveram, com posterior negativação quanto à presença do P. berghei.This study was carried out to evaluate the fortuitons advantage of using gamma irradiation in the prophylaxis of transmissible malaria by blood transfusion, with mice as the experimental model. In the first step, when the infected blood with Plasmodium berghei was submitted to 2,500rad and 5,000rad, with or without metronidazol, there was no success, because the animals presented parasitaemia and died after inoculation of irradiated blood. However, there was partial success in the second step, when the infected blood received 10,000 and 15,000rad, and was inoculated in mice, which showed infection, and presented a survival rate of 20% and 40%, respectively, with later negativation of blood infected by P. berghei.

  18. Variação da densidade anofélica com o uso de mosquiteiros impregnados com deltametrina em uma área endêmica de malária na Amazônia Brasileira Variation of anopheles density with deltamethrin-impregnated mosquito nets in an endemic malaria area of the Brazilian Amazon

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    João Barberino Santos

    1999-04-01

    Full Text Available Em 1992, foi realizado um ensaio de campo com mosquiteiros impregnados com deltametrina, em uma área endêmica de malária no Município de Costa Marques, Rondônia. No período de baixa transmissão, os mosquiteiros impregnados (MI diminuíram a densidade vetorial no intradomicílio, de modo semelhante, porém, aos mosquiteiros não impregnados (NI na maioria das avaliações-controle. Por outro lado, na época de alta transmissão, os MI provocaram diminuição significante da média horária de anofelinos capturados, ao passo que, nas casas com NI, verificou-se aumento do número de mosquitos capturados. No peridomicílio, em geral, não houve diferença do número de anofelinos capturados entre MI e NI. No grupo MI, a espécie mais capturada foi o An. darlingi (63,2%, mais freqüente no peridomicílio, seguida pelo An. deaneorum (35,3%, mais freqüente no intradomicílio. Os MI diminuíram a densidade vetorial no intradomicílio pelo efeito excito-repelente, sem diminuí-la, contudo, no peridomicílio.In 1992 a survey on the use of deltamethrin-impregnated mosquito nets was conducted in the municipality of Costa Marques, Rondonia. In the intradomicile, impregnated nets decreased the vector density at rates similar to those for non-impregnated nets during low-transmission periods; during high anopheline density periods, they led to a significant reduction in vector density, while in the non-impregnated net group there was an increase in the number of anophelines captured. There was no change in vector density in the peridomicile. In the impregnated net group, the most frequently captured species was Anopheles darlingi (63.2%, found mostly in the peridomicile, while Anopheles deaneorum (35.3% was most frequent indoors. The impregnated mosquito nets' excitatory-repellent effect decreased the intradomiciliary vector density but did not alter density in the peridomicile.

  19. Variable impact of Malaysia's national language planning on non-Malay speakers in Sarawak Impacto variável do planejamento linguístico nacional da Malásia sobre não falantes do Malaio em Sarawak

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    Su-Hie Ting

    2012-06-01

    Full Text Available The study examined the impact of the national language policy on the language use of three main ethnic groups in the Malaysian state of Sarawak. The data analyzed was based on a sociolinguistic survey on language use in six domains that involved 937 Malay, Chinese and Iban adolescents from three major towns in Sarawak. The results showed that the use of Bahasa Malaysia exceeded English usage for all three ethnic groups, showing the success of compulsory education in the national language. However, the language planning has greater impact on the Iban than on the Chinese who are shifting away from the ethnic languages of the Chinese sub-groups to Mandarin Chinese. The availability of an alternative standard language with international standing which also functions as a symbol of cultural solidarity compromises the impact of the national language policy.Este estudo examinou o impacto da política de ensino da língua nacional de três principais grupos étnicos no estado malaio de Sarawak. Os dados analisados basearam-se em uma pesquisa sociolinguística sobre o uso da língua em seis domínios e envolveu 937 adolescentes malaios, chineses e Iban de três grandes cidades de Sarawak. Os resultados mostraram que o uso da língua Bahasa da Malásia superou o uso do inglês para todos os três grupos étnicos, comprovando o sucesso da escolaridade obrigatória em língua nacional. No entanto, o planejamento do estudo da língua tem maior impacto sobre o Iban do que sobre os chineses. Estes estão se afastando das línguas étnicas dos subgrupos chineses para o chinês Mandarim. A disponibilidade de uma língua alternativa padrão, com prestígio internacional, que também funciona como um símbolo de solidariedade cultural, compromete o impacto da política de ensino da língua nacional.

  20. Compatibilidade de Dicyma pulvinata com defensivos agrícolas e eficiência do biocontrole do mal-das-folhas da seringueira em campo Compatibility of Dicyma pulvinata with pesticides and biocontrol efficiency of South American leaf blight of rubber tree under field conditions

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    Débora Ferreira Melo

    2008-02-01

    Full Text Available O objetivo deste trabalho foi avaliar quatro isolados do fungo antagonista Dicyma pulvinata quanto à compatibilidade com defensivos agrícolas e adjuvantes, e a eficiência desses isolados no controle do mal-das-folhas (Microcyclus ulei da seringueira (Hevea sp. em campo. A compatibilidade dos isolados com defensivos e adjuvantes foi avaliada com base no crescimento micelial e na esporulação do fungo, em testes conduzidos in vitro. Para avaliação da eficiência do antagonista contra M. ulei, em campo, os quatros isolados do antagonista foram comparados ao controle exercido pelo tratamento com os fungicidas propiconazol + mancozeb. Os ensaios conduzidos em laboratório indicaram a incompatibilidade de D. pulvinata com os fungicidas benomyl, carbendazim, mancozeb, propiconazol e, ainda, com o inseticida acaricida endosulfan. Dois dos adjuvantes testados (Tween 20 e Tween 80 não afetaram o desenvolvimento do fungo. Foi comprovada a ação do antagonista D. pulvinata sobre M. ulei, em campo, com destaque para os isolados CEN 62 e CEN 93, que apresentaram eficiência de controle semelhante ao tratamento fungicida padrão.The objective of this work was to evaluate four isolates of the antagonist fungus Dicyma pulvinata in terms of its compatibility with chemical pesticides and adjuvants products, and the efficiency of these isolates as biocontrol agent against South American leaf blight (Microcyclus ulei of rubber tree (Hevea sp. under field conditions. Isolates compatibility with chemical pesticides and adjuvants was evaluated on mycelial growth and fungus sporulation in vitro. To assess the efficiency of the antagonist against M. ulei under field conditions, the four isolates were compared to the control by the fungicide mixture propiconazol + mancozeb. The assays showed incompatibility of the antagonistic fungus with the fungicides benomyl, carbendazim, mancozeb, propiconazol, besides the insecticide-acaricide endosulfan. Two of the adjuvants

  1. Malaria transmission model for different levels of acquired immunity and temperature-dependent parameters (vector Modelo de transmissão de malária em diferentes níveis de imunidade e de parâmetros temperatura-dependentes (vetor

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    Hyun M Yang

    2000-06-01

    Full Text Available OBJECTIVE: Describe the overall transmission of malaria through a compartmental model, considering the human host and mosquito vector. METHODS: A mathematical model was developed based on the following parameters: human host immunity, assuming the existence of acquired immunity and immunological memory, which boosts the protective response upon reinfection; mosquito vector, taking into account that the average period of development from egg to adult mosquito and the extrinsic incubation period of parasites (transformation of infected but non-infectious mosquitoes into infectious mosquitoes are dependent on the ambient temperature. RESULTS: The steady state equilibrium values obtained with the model allowed the calculation of the basic reproduction ratio in terms of the model's parameters. CONCLUSIONS: The model allowed the calculation of the basic reproduction ratio, one of the most important epidemiological variables.OBJETIVO: Propõe-se um modelo compartimental para descrever a transmissão de malária, levando em consideração duas populações envolvidas: o hospedeiro humano e o vetor mosquito. MÉTODOS: Desenvolveu-se um modelo matemático baseado nas seguintes características: em relação ao hospedeiro humano, assumiu-se a existência de imunidade adquirida e de memória imunológica que, em uma reinfecção, leva ao reforço da resposta imune; em relação ao vetor mosquito, levou-se em consideração que o período médio de desenvolvimento desde ovo até mosquito adulto e o período de incubação extrínseco de parasitas (transformação de mosquitos infectados mas não-infecciosos em mosquitos infecciosos são dependentes de temperatura ambiente. RESULTADOS: Foram obtidos os valores do equilíbrio no estado estacionário do modelo proposto. Da análise da estabilidade dos pontos de equilíbrio, foi determinada a razão de reprodutibilidade basal. CONCLUSÕES: Foi obtida uma variável epidemiológica importante, a razão de

  2. Sobre as relações entre o sexual e o mal-estar na civilização: uma discussão acerca das perspectivas freudianas the relationship between sexuality and the discontent in civilization: a debate regarding on Freudian perspectives

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    Clara Virginia de Q. Pinheiro

    2006-01-01

    Full Text Available O objetivo do presente artigo é examinar as formulações freudianas acerca das relações entre o sujeito às voltas com encontrar possibilidades de satisfação libidinal e o avanço da civilização. Consideramos que podemos estabelecer diferenças entre duas concepções freudianas: 1 uma oposição entre sexualidade e coletividade; 2 a civilização como vínculo libidinal. A primeira refere-se ao texto "Moral sexual civilizada e doença nervosa moderna" (1908 e a segunda, ao texto de 1930, "Mal-estar na civilização". A propósito da noção de civilização, estabelecemos uma articulação entre Freud e Norbert Elias, na medida em que partimos da idéia de que o conceito de civilização em Freud remete à experiência propriamente moderna de formação de laço social. Trata-se, com efeito, de uma forma de sociabilidade baseada na auto-regulação.This article’s aim is to analyze the Freudian formulations regarding the relationship between the subject, occupied with finding possibilities of libidinous satisfaction, and the advance of civilization. We consider that a difference can be established between two Freudian conceptions 1 an opposition between sexuality and collectivity; 2 civilization as a libidinous bond. The first one is found in the text "Civilized sexual morality and modern nervousness" (1908, and the second in the text of 1930, "Civilization and its discontents". Regarding the conception of civilization, we relate ideas of Freud and Norbert Elias, since we consider that the concept of civilization in Freud refers to the modern experience of social bond. Therefore, it is a form of sociability based on self-regulation.

  3. Ação de mosquiteiros impregnados com deltametrina sobre a morbidade da malária em uma área da Amazônia Brasileira The effect of bed nets impregnated with deltamethrin on malaria morbidity in an endemic area of the Brazilian Amazonian Region

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    João Barberino Santos

    1998-02-01

    Full Text Available Em 1992 foi feita uma investigação sobre o efeito protetor do uso de mosquiteiros impregnados com deltametrina, em uma população do município de Costa Marques, Rondônia, sujeita à transmissão malárica. Os mosquiteiros impregnados se comportaram de modo semelhante aos não impregnados, sem modificar os índices de infecção na época de baixa transmissão. A análise multivariada, por idade e títulos de anticorpos, mostrou uma proteção significante para o grupo com mosquiteiros impregnados contra o risco de infecção, apenas na estação de alta transmissão, quando os mosquiteiros foram usados mais regularmente. Não houve diferença no efeito de ambos os tipos de mosquiteiros na prevenção de elevadas parasitemias. Ao fim do estudo, ocorreu diminuição da prevalência de esplenomegalia em ambos os grupos, porém houve uma aparente recuperação da taxa normal de hematócrito em menores de 15 anos de idade em uso de mosquiteiros impregnados.In 1992 an investigation regarding the value of insecticide impregnated mosquito nets was conducted in the municipality of Costa Marques, Rondonia. Impregnated mosquito nets gave similar protection to those not impregnated, without modifying the incidence of infection during the season of low transmission. The multivariate analysis for age and antibody titre showed a significant protection of impregnated nets against the risk of infection only in the season of high transmission, when bed nets were used more correctly. There was no difference in the effect of both kinds of bed nets in the prevention of high parasitaemia. At the end of the study, there was a reduction of the prevalence of splenomegaly in both groups but hematocrit values rose to normal in the below 15 year olds using impregnated nets.

  4. Aspectos sócio-econômicos dos indivíduos com malária importada na região metropolitana de São Paulo, Brasil: I - Caracterização da população e conhecimento sobre a doença Social and economic aspects of patients with imported malaria in the metropolitan region of S. Paulo City, S. Paulo State, Brazil: I - Characterization of the population and knowledge of the disease

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    Maria José Chinelatto Pinheiro Alves

    1990-08-01

    Full Text Available Com o objetivo de conhecer o perfil sócio-econômico dos indivíduos que se deslocaram das áreas endêmicas de malária do país, foram estudadas 566 pessoas com suspeita de malária que procuraram a confirmação diagnostica no Laboratório de Malária da Região Metropolitana de São Paulo da Superintendência de Controle de Endemias (SUCEN. As informações foram obtidas através da aplicação de formulário, no período de novembro de 1986 a junho de 1987. Da população estudada, 345 (61,0% residiam na área endêmica, 479 (84,6% eram do sexo masculino, 513 (90,7% estavam na faixa etária de 15 a 55 anos e 307 (54,2% apresentaram hemoscopia positiva para plasmódio. Com relação à ocupação na área de transmissão, observou-se que 109 (19,3% estavam ligados a atividade de extração de minerais, 74 (13,2% à agricultura e 46 (8,1% à atividade de transporte. A análise da escolaridade mostrou que 486 (85,9% tinham 1° ou 2° grau. Quanto ao conhecimento sobre a doença, 384 (67,8% declararam pelo menos 1 malária anterior e 491 (86,8% associavam à doença a presença do vetor. Dentre os 221 indivíduos residentes em São Paulo, 207 (93,7% conheciam o risco de contrair malária por ocasião do deslocamento para área de transmissão. Daqueles residentes na área endêmica, 336 (97,4% tinham conhecimento do risco de contrair a doença naquela região. O intervalo transcorrido entre os primeiros sintomas e a procura de atendimento médico em 386 (68,2% indivíduos variou de 0 a 3 dias. As freqüências das variáveis estudadas mostraram de acordo com o resultado hemoscópico e o local da residência, diferenças estatísticas relevantes.With a view to discovering the social and economic characteristics of people from endemic malarial areas of Brazil, 566 suspected malaria cases were studied at the S. Paulo City Metropolitan Region Malaria Laboratory. Data were obtained by means of the application of standardized questionnaires over the

  5. "Un monstruo absoluto": Armando Normand y la sublimidad del mal

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    Carlos Guillermo Páramo Bonilla

    2010-05-01

    Full Text Available Entre todos los personajes acusados de crímenes atroces en las caucheras del Putumayo (ca. 1912, ninguno ha producido tanto horror y fascinación como Armando Normand. En este artículo seguimos la pista de esta vida infame, incorporando el camino material previamente no reseñado y examinando cómo y por qué ingresó a la mitología de la frontera, en cuanto arquetipo del terror. Por lo mismo se observa de cerca su relación con las figuras de Roger Casement y el emblemático Kurtz de "El corazón de las tinieblas" de Joseph Conrad. Asimismo se aprovecha la circunstancia para discutir con algunos planteamientos de Michael Taussig, Gananath Obeyesekere y Michel Foucault.

  6. Videogame: é do bem ou do mal? Como orientar pais

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    Luciana Alves

    2011-06-01

    Full Text Available Desde a década de 70 milhares de crianças, adolescentes e adultos praticam jogos de computador ou videogame. O objetivo deste artigo foi identificar os efeitos deste artefato tecnológico para a cognição, sua aplicabilidade e sua influência sobre o comportamento e a saúde do jogador e, desta forma, delinear orientações para pais e profissionais de saúde que lidam com crianças e adolescentes. Na primeira parte do artigo são apresentados alguns efeitos negativos e positivos dos jogos; na segunda é proposto um conjunto de orientações que podem tornar a brincadeira mais segura; e na última parte, as considerações finais. Concluiu-se que o videogame é uma ferramenta capaz de aperfeiçoar as habilidades cognitivas e perceptivas, sendo os jogos educacionais apontados como uma experiência benéfica aos seus usuários, e que as repercussões negativas se referem, principalmente, ao efeito daqueles com conteúdo de violência.

  7. Analisis Yuridis Tentang Tanggung Jawab Notaris Kaitannya Dengan Mal Administrasi

    OpenAIRE

    Nadapdap, Masda

    2010-01-01

    A notary in charge of organizing his client always belongs to a group of persons holding a trustworthy position because he is a person who approves or gives an authentic power for a notarial document (act) truly made before him based on the standard notary’s professional ethics and the existing legal stipulation. As a public officer with an authority to make and issue a notarial document (act), a notary is required to work independently, honestly, not taking sides, full of responsibility, and...

  8. MAL decreases the internalization of the aquaporin-2 water channel.

    NARCIS (Netherlands)

    Kamsteeg, E.J.; Duffield, A.S.; Konings, I.B.M.; Spencer, J.; Pagel, P.; Deen, P.M.T.; Caplan, M.J.

    2007-01-01

    Body water homeostasis depends critically on the hormonally regulated trafficking of aquaporin-2 (AQP2) water channels in renal collecting duct epithelial cells. Several types of posttranslational modifications are clearly involved in controlling the distribution of AQP2 between intracellular vesicl

  9. Tvorba marketingové strategie malé firmy

    OpenAIRE

    Šťastná, Jana

    2011-01-01

    This bachelor thesis deals with marketing strategy of mid-sized company called TRIPOR Ltd., the business deals with buying and selling porcelain and glass .The business is located in Klášterec nad Ohří. The aim of this work is to analyze the current marketing strategy of the company, its evaluation, suggestion and marketing strategy of the company. The work is divided into two chapters. The first chapter deals with the theoretical part, which describes the particular theory of marketing. The ...

  10. Mitochondria and the economy of stress (mal)adaptation

    NARCIS (Netherlands)

    Morava, E.; Kozicz, T.L.

    2013-01-01

    Stress-associated diseases, like depression have a life time prevalence of up to 20%, and approximately 18.4 million people in Europe suffer from depression. Despite decades of research, we still do not understand completely this complex brain disease. Increasing body of correlative evidence implica

  11. O mal-estar docente em gestores escolares

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    Cátia Cristina Xavier Mazon

    2013-08-01

    Full Text Available This research aimed to identify and analyze the impact of stressful events associated with the school administrators in teacher malaise. 29 managers participated in his capacity as directors or deputy directors of the municipal system, the interior of São Paulo, with responses to the Inventory IMPIL (Evaluación Psicológica Del Estrés por InestabilidadLaboral - FIGUEROA; SCHUFER, 2006. The results indicate the presence of stressors in all areas assessed at different rates. The highest ranking stressors were concerns with health, emotional Diseases and economic concerns. The degree of discomfort tends to increase with age, but since the entry into this function. The extensive powers of management, indicate the occurrence of different degrees of impact between the groups, demonstrating that subjectivity needs to be considered for proposing improvements in working conditions and health organizations. Social changes, the demands of educational reforms and lack of recognition of the profession were associated with teacher malaise.

  12. Ulutshit zhizn v malõhh gorodahh mozhno / Georgi Bõstrov

    Index Scriptorium Estoniae

    Bõstrov, Georgi, 1944-

    2007-01-01

    Konstitutsioonierakonna nimekirjas Riigikokku kandideeriv Maardu linnapea teeb ettepaneku, kuidas suurendada väikeste omavalitsuste tulu. Partei ettepanekutest maksusüsteemi muutmiseks. Erakond peab oluliseks, et pension ei oleks väiksem kui 45% palgast, tulumaksuvaba miinimum peab vastama elatusmiinimumi suurusele

  13. Marketingová komunikace malé firmy na internetu

    OpenAIRE

    Knápková, Kamila

    2014-01-01

    In the thesis I focus on selected instruments of internet marketing which are suitable for small size companies. The terms internet advertising and internet sales promotion instruments are explained in the first chapter. Sufficient part of the thesis is dedicated to the rules of webpage creation and the means of their optimization for search engines (SEO) as well as to the options of their attendance measuring (Google Analytics).The second chapter is focused on the concept of content marketin...

  14. Mal de amores a la vuelta de ocho siglos

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    Elías Sevilla Casas

    1999-10-01

    Full Text Available Se comparten con los lectores las reflexiones sobre un cuerpo de teoría sociológica que se esta probando dentro de un proyecto de investigación en curso sobre las lógicas que rigen ciertos tipos de relaciones íntimas de afecto, erotismo y sexo narradas por una muestra de mujeres y hombres de la ciudad de Cali.

  15. O mal-estar na literatura: uma leitura comparatista

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    José Henrique Prado da Silva

    2004-01-01

    Full Text Available The aim of this work is developing a comparative study between two important short stories of world-wide literature: The fall of the house of Usher, by Edgar Allan Poe and A house taken over, by Julio Cortázar. First we´re going to make an individual analysis of each one of the stories in order to, after that, compare the two texts, searching to identify its similarities and differences. The methodology used in our work is based upon the theory of the intertextuality, that tries to point up, in general lines, how an author uses another one as his source, i.e., how a work finds its own originality taking for base another work already done. In this particular case, that means analyzing the uses made by Cortázar of given elements found in Poe´s short story, i.e., the contributions brought by the Argentine author when making the re-reading of the story of the North American writer. It´s important to say our intention is not to try to identify which one of the two authors is best, but look for common points in the two short stories, the distinguishing marks that stand out in both texts. The bibliography that we will use in our study contains not only works related specifically to the studied writers, but it also includes texts, books and articles linked to the areas of comparative literature and literary theory.

  16. Obchodní strategie malého podniku

    OpenAIRE

    Hourová, Tereza

    2013-01-01

    The thesis deals with the business strategy of a middle-sized entrepreneur in the food manufacturing industry. The theoretical part explains basic terms, introduces methods of a strategic analysis and describes basic approaches to formulating the strategy. The practical part contains the strategic analysis of a specific entrepreneur created using the PEST analysis, the Porter five forces analysis, and the Value Chain Analysis. The practical part also includes suggested business strategies det...

  17. Meio ambiente e saúde: metodologia para análise espacial da ocorrência de malária em projetos de assentamento Medio ambiente y salud: metodología para análisis espacial de la ocurrencia de malaria en proyectos de asentamiento Environment and Health: a methodological approach for spatial assessment of malaria transmission in colonization projects in the Brazilian Amazon

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    Marcia Caldas de Castro

    2007-12-01

    Full Text Available A transmissão de malária em projetos de assentamento na Amazônia, definida como malária de fronteira, é resultado de um intrincado processo envolvendo fatores biológicos, ecológicos, socioeconômicos e comportamentais, apresentando uma transição temporal de altas a baixas taxas ao longo de aproximadamente oito anos. Como resultado, um dos grandes desafios é a compreensão desse processo, através da identificação das variáveis determinantes da transmissão, considerando-se dimensões temporais e espaciais. Neste artigo é apresentada uma abordagem metodológica que caracteriza perfis de risco de malária em projetos de assentamento, a partir de uma análise multidisciplinar. Composta de três etapas, a abordagem combina análise espacial, geoestatística e modelos de Grade of Membership. Os resultados ressaltam a importância de medidas de controle diferenciadas de acordo com o estágio do projeto de assentamento (implementação recente ou antiga e o nível de transmissão em cada localidade.La transmisión de malaria en proyectos de asentamiento en la Amazonia, definida como malaria de frontera, es el resultado de un intrincado proceso, involucrando factores biológicos, ecológicos, socioeconómicos y comportamentales, presentando una transición temporal de altas a bajas tasas a lo largo de aproximadamente ocho años. Como resultado, uno de los grandes desafíos es la comprensión de ese proceso, a través de la identificación de las variables determinantes de la transmisión, habiéndose considerado dimensiones temporales y espaciales. En este artículo es presentado un abordaje metodológico que caracteriza perfiles de riesgo de malaria en proyectos de asentamiento, a partir de un análisis multidisciplinario. Compuesto de tres etapas, el abordaje combina análisis espacial, geoestadística y modelos de Grade of Membership. Los resultados resaltan la importancia de medidas de control diferenciadas, de acuerdo a la etapa del

  18. Epidemiological and ecological aspects related to malaria in the area of influence of the lake at Porto Primavera dam, in western São Paulo State, Brazil Aspectos epidemiológicos e ecológicos relacionados à malária na área de influência do lago da Represa de Porto Primavera, região oeste do Estado de São Paulo, Brasil

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    Almério de C. Gomes

    2008-10-01

    this paper.Foi realizada pesquisa na área de influência do lago da Usina Hidrelétrica de Porto Primavera, região oeste do Estado de São Paulo, para estudar aspectos ecológicos e epidemiológicos da malária na localidade e acompanhar o perfil das populações de anofelinos frente às mudanças decorrentes do impacto ambiental pela formação do lago. Mosquitos capturados foram analisados pelo Índice de Abundância de Espécies Padronizado (IAEP, antes e durante o enchimento do reservatório (cotas 253 e 257 m. A população humana local foi estudada por meio de teste parasitológico (gota espessa e esfregaço sangüíneo, testes moleculares (PCR e testes sorológicos. A sorologia consistiu na reação de ELISA com peptídeos sintéticos correspondentes à porção repetitiva da proteína circumsporozoíta (CSP de Plasmodium vivax clássico, e suas variantes VK247 e "vivax-like", P. malariae e P. falciparum; e reação de Imunofluorescência Indireta (RIFI com formas assexuadas de P. vivax, P. malariae e P. falciparum. Os resultados do estudo entomológico indicaram que, embora a população de Anopheles darlingi tenha aumentando após o enchimento, permaneceu em baixa densidade. Não foi detectada malária nem a presença de parasitos ou de DNA parasitário nos habitantes estudados. No entanto, foi observada baixa freqüência de anticorpos contra formas assexuadas e significativa prevalência de anticorpos contra esporozoítos de P. vivax e suas variantes, P. falciparum e P. malariae, que poderiam decorrer de contatos prévios, recentes ou não, com plasmódios humanos ou símios (o ciclo silvestre foi evidenciado em estudo paralelo realizado na mesma área. Por outro lado, estes resultados sugerem que, como em outros lugares onde existem vetores potenciais da malária, as condições epidemiológicas poderiam potencialmente permitir a transmissão da malária na área de influência do lago de Porto Primavera, se indivíduos infectados fossem introduzidos em n

  19. Colonização micorrízica arbuscular e tolerância ao mal-do-Panamá em mudas de banana-maçã Colonisation of arbuscular mycorrhiza and tolerance to Panama disease in seedlings of the maçã banana

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    Deusiane Batista Sampaio

    2012-09-01

    Full Text Available O objetivo desse trabalho foi avaliar o efeito da colonização micorrízica arbuscular na tolerância da bananeira, cv. Maçã, ao mal-do-Panamá, sob diferentes fontes de nutrientes. Utilizou-se um delineamento inteiramente casualizado com fatorial 2 x 4 [2 densidades de esporos de FMA nativos (D1 - 3.500 esporos kg-1 solo e D2 - 7.000 esporos kg-1 solo e 4 diferentes concentrações de fontes de nutrientes - três de solução nutritiva (SN 40%, SN 70% e SN 100% e uma de biofertilizante 100% (B4] com três repetições. Após o plantio inoculou-se Fusarium oxysporum f.sp. cubense e posteriormente avaliou-se matéria seca da parte aérea (MSPA, o teor de fósforo foliar (P, a colonização micorrízica, o pH do solo e o índice de severidade da doença (ID. As diferentes fontes de nutrientes influenciaram a matéria seca da parte aérea, o teor de fósforo, a colonização micorrízica e o índice de severidade da doença, porém não influenciaram o pH da solução do solo. O biofertilizante não atendeu à demanda nutricional das plantas, as quais se mostraram pouco desenvolvidas. Porém proporcionou intensa colonização micorrízica e menor índice de severidade da fusariose, o qual aumentou com a adubação mineral.The aim of this study was to evaluate the effect of the colonization of arbuscular mycorrhiza on the tolerance to Panama disease of the banana plant cv. maçã under different sources of nutrients. A completely randomized design was employed, having a 2 x 4 factorial [2 densities of native FMA spores (D1 - 3,500 spores kg-1 soil and D2 - 7000 spores kg-1 soil and four different concentrations of nutrient sources - three of a nutrient solution (SN 40%, SN 70% and SN 100% and a 100% solution of bio-fertiliser (B4], with three replications. After planting, the seedlings were inoculated with Fusarium oxysporum f.sp. cubense, and later the shoot dry matter, leaf phosphorus content, mycorrhizal colonization, soil pH and disease

  20. 中药熏洗结合局部上药微波导热治疗外阴白色病变50例临床观察%Clinical Observation of 50 Cases of White Lesions of the Vulva Treated with Chinese Medicine Fumigation and Local Medicine Microwave Ther-mal Irradiation

    Institute of Scientific and Technical Information of China (English)

    潘怡

    2016-01-01

    Objective To observe the clinical efficacy on white lesions of the vulva treated with Chinese medicine fumigation and local medicine microwave thermal irradiation. Methods One hundred out-patients of white lesions of the vulva were randomized into a treatment group and a control group,50 cases in each one. In the treatment group,the fumigation was applied locally with qubai zhiyang fang,followed by local application of oleum morrhuae drops,vitamin E capsule and fluocinonide ointment,as well as microwave ther-mal irradiation. In the control group,the local application of fluocinonide ointment and microwave thermal ir-radiation were applied. The treatment was given once a day,10 treatments made one session. The evaluation was done after 3 sessions. Results The total effective rate was 96. 0% in the treatment group and was 72. 0% in the control group after treatment,indicating the significant difference in comparison(P < 0. 01).Conclusion The combined therapy of Chinese medicine fumigation and local medicine microwave thermal irradiation achieves the definite efficacy on white lesions of the vulva. This therapy is simple in application and deserves to be promoted.%目的 观察中药熏洗结合局部上药微波导热方法治疗外阴白色病变的临床疗效.方法 将门诊100例外阴白色病变患者按数字随机表法分为治疗组和对照组,每组50例.治疗组采用中药"去白止痒方"加减熏洗外阴,其后病灶局部涂擦鱼肝油滴剂、维生素E胶囊及氟轻松软膏,再进行微波导热照射治疗;对照组采用局部氟轻松软膏上药加微波导热治疗.两组治疗均1次/d,每10次为1个疗程,完成3个疗程后进行疗效评价.结果 治疗后治疗组总有效率96.0%,对照组总有效率72.0%,两组疗效比较,差异有统计学意义(P<0.01).结论 中药熏洗结合局部上药微波导热治疗外阴白色病变疗效确切、方法简便,值得在基层推广使用.

  1. Clinical Observation of 50 Cases of White Lesions of the Vulva Treated with Chinese Medicine Fumigation and Local Medicine Microwave Ther-mal Irradiation%中药熏洗结合局部上药微波导热治疗外阴白色病变50例临床观察

    Institute of Scientific and Technical Information of China (English)

    潘怡

    2016-01-01

    目的 观察中药熏洗结合局部上药微波导热方法治疗外阴白色病变的临床疗效.方法 将门诊100例外阴白色病变患者按数字随机表法分为治疗组和对照组,每组50例.治疗组采用中药"去白止痒方"加减熏洗外阴,其后病灶局部涂擦鱼肝油滴剂、维生素E胶囊及氟轻松软膏,再进行微波导热照射治疗;对照组采用局部氟轻松软膏上药加微波导热治疗.两组治疗均1次/d,每10次为1个疗程,完成3个疗程后进行疗效评价.结果 治疗后治疗组总有效率96.0%,对照组总有效率72.0%,两组疗效比较,差异有统计学意义(P<0.01).结论 中药熏洗结合局部上药微波导热治疗外阴白色病变疗效确切、方法简便,值得在基层推广使用.%Objective To observe the clinical efficacy on white lesions of the vulva treated with Chinese medicine fumigation and local medicine microwave thermal irradiation. Methods One hundred out-patients of white lesions of the vulva were randomized into a treatment group and a control group,50 cases in each one. In the treatment group,the fumigation was applied locally with qubai zhiyang fang,followed by local application of oleum morrhuae drops,vitamin E capsule and fluocinonide ointment,as well as microwave ther-mal irradiation. In the control group,the local application of fluocinonide ointment and microwave thermal ir-radiation were applied. The treatment was given once a day,10 treatments made one session. The evaluation was done after 3 sessions. Results The total effective rate was 96. 0% in the treatment group and was 72. 0% in the control group after treatment,indicating the significant difference in comparison(P < 0. 01).Conclusion The combined therapy of Chinese medicine fumigation and local medicine microwave thermal irradiation achieves the definite efficacy on white lesions of the vulva. This therapy is simple in application and deserves to be promoted.

  2. Relação entre hábitos bucais, alterações oronasofaringianas e mal-oclusões em pré-escolares de Vitória, Espírito Santo, Brasil The relationship between oral habits, oronasopharyngeal alterations, and malocclusion in preschool children in Vitória, Espírito Santo, Brazil

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    Adauto Emmerich

    2004-06-01

    Full Text Available O objetivo deste estudo foi estimar a prevalência das mal-oclusões e variáveis a elas associadas, como hábitos deletérios (HD e as alterações oronasofaringianas (AO, respiração bucal, deglutição atípica e fonação atípica, em crianças com idade de três anos, no Município de Vitória, Espírito Santo, Brasil. A amostra constituiu-se de 291 crianças de ambos os sexos, matriculadas nos Centros de Educação Infantil, selecionadas por meio de amostragem probabilística por conglomerados. A análise de regressão logística indicou maior risco relativo (RR de crianças com sobressaliência alterada, mordida aberta e mordida cruzada, em apresentar: respiração bucal (RR = 1,89; IC: 1,56-2,03, (RR = 2,46; IC: 2,00-3,02, (RR = 1,45; IC: 1,23-1,72; deglutição atípica (RR = 2,57; IC: 1,87-3,52, (RR = 3,49; IC: 2,53-4,81, (RR = 1,86; IC: 1,46-2,39 e fonação atípica (RR = 2,25; IC: 1,66-3,05, (RR = 3,18; IC: 2,38-4,25, (RR = 1,71; IC: 1,32-2,22, respectivamente. Foi mostrado haver associação entre sucção de dedo e de chupeta com sobressaliência alterada (p The objective of this study was to estimate the prevalence of malocclusion and associated variables such as deleterious habits (DH and oronasopharyngeal alterations (OA, mouth breathing, atypical phonation, and atypical swallowing in three-year-old children in Vitória, Espírito Santo State, Brazil. The sample included 291 children of both sexes enrolled in a Children's Educational Center and selected through probability sampling by conglomerates. Logistic regression indicated a high relative risk (RR in children with altered overjet, open bite, and cross-bite to present mouth breathing (RR = 1.89; CI: 1.56-2.03, (RR = 2.46; CI: 2.00-3.02, (RR = 1.45; CI: 1.23-1.72; atypical swallowing (RR = 2.57; CI: 1.87-3.52, (RR = 3.49; CI: 2.53-4.81, (RR = 1.86; CI: 1.46-2.39; and atypical phonation (RR = 2.25; CI: 1.66-3.05, (RR = 3.18; CI: 2.38-4.25, (RR = 1.71; CI: 1

  3. "O que vêm da terra não faz mal": relatos de problemas relacionados ao uso de plantas medicinais por raizeiros de Diadema/SP "Natural and therefore free of risks": adverse effects, poisonings and other problems related to medicinal herbs by "raizeiros" in Diadema/SP

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    Juliana Lanini

    2009-03-01

    Full Text Available A crença de que medicamentos à base de plantas são isentos de riscos à saúde faz parte da bagagem cultural da população afeita ao seu uso: "o que vêm da terra não faz mal". No entanto, o potencial tóxico, as características específicas do usuário, a possibilidade de contaminação e a falta de regulamentação constituem fatores de risco para a ocorrência de reações adversas, intoxicações e outras complicações decorrentes de seu uso. Foram realizadas entrevistas semi-estruturadas junto a 20 raizeiros (vendedores de ervas "in natura" na cidade de Diadema/SP. Foram relatados 40 casos de problemas relacionados ao uso de 22 espécies de plantas medicinais. As espécies mais citadas foram Luffa operculata - buchinha (7 casos, Senna alexandrina - sene (4 casos e Paullinia cupana - guaraná (3 casos. Dentre os sinais e sintomas relatados, os mais freqüentes foram relacionados ao sistema nervoso central, problemas gastrointestinais e cardiovasculares. Os entrevistados também relataram um caso de aborto relacionado ao uso de S. alexandrina e três casos de óbito após a ingestão do chá do fruto de L. operculata. O caráter "natural" das plantas medicinais não é sinônimo de ausência de riscos para a população usuária. É necessária a implantação de políticas de fitofarmacovigilância eficientes, a fim de tornar o consumo mais racional e, deste modo, minimizar os riscos à população usuária.Traditionally, medicinal herbs have been considered gentle and harmless because of their natural origin: "natural and therefore free of risks". However, toxic potential, various consumer-related factors (such as age, disease factors, pregnancy, etc, contamination, and lack of regulation concerning quality control are some of the risk factors deemed to be associated with herbal adverse reactions, poisonings and other complications. Over a 7-month period, semi-structured interviews were carried out with 20 "raizeiros" (traditional

  4. 钽棒植入联合自体骨髓间充质干细胞移植治疗早期股骨头缺血性坏死%Early Clinical Results of Implantation of Tantalum Rod Combined Transplantation of Autologous Bone Marrow Mesenchy-mal Stem Cells for Early Stage of Avascular Necrosis of Femoral Head

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    梁红锁; 黄克; 李林; 张波; 韦程寿

    2014-01-01

    Objective:To study the effects of implantation of tantalum rod and transplantation of autologous bone mar-row mesenchymal stem cells for early stage of avascular necrosis of femoral head .Methods:27 patients with avascular necrosis of femoral head in the early stage were treated with implantation of tantalum rod and transplantation of autolo-gous bone marrow mesenchymal stem cells .Results:The average period of follow-up was thirteen months (7 ~ 24 months) .Pain of all patients disappeared .The movement range of the hip joint was normal or approximate to normal . Except two cases evolved to stage of ARCOⅢ ,X-ray showed that cystic degeneration disappeared .The Harris score was 54 .2 ± 7 .1 before operation and it increased significantly to 83 .9 ± 8 .6 after operation .Conclusion:It has the ad-vantage to minimal damage of implantation of tantalum rod and transplantation of autologous bone marrow mesenchy-mal stem cells for early stage of avascular necrosis of femoral head .It is an effective way for the treatment of femoral head necrosis .The short-term efficacy is good .%目的:观察钽棒植入联合自体骨髓间充质干细胞移植治疗早期股骨头缺血性坏死的临床疗效。方法:对27例ARCOⅠ、Ⅱ期的ANFH患者采用股骨头髓芯减压后植入钽棒并联合自体骨髓间充质干细胞移植。结果:所有患者经过7~24个月(平均13个月)的随访,关节疼痛基本消失,活动范围接近或恢复正常,除2例患者进展为ARCOⅢ期外,其余股骨头均无塌陷,影像学检查结果示股骨头囊性变消失,Harris评分由术前的(54.2±7.1)分提高到术后(83.9±8.6)分。结论:钽棒植入联合自体骨髓间充质干细胞移植治疗早期股骨头缺血性坏死,具有创伤小、疗效确切等优点,近期临床疗效良好。

  5. Cisticercose humana diagnosticada em hospital geral, São Paulo, SP (Brasil Human cysticercosis in a general hospital in S.Paulo, Brazil

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    Aluízio de Barros Barreto Machado

    1988-06-01

    Full Text Available Foi realizado estudo retrospectivo de pacientes internados no Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo (Brasil, no período de 7 anos (1979 a 1985, tendo sido diagnosticados 260 casos de cisticercose, correspondendo a 0,2% do total estudado. Os dados obtidos mostraram uma distribuição aproximadamente igual quanto ao sexo e o acometimento maior na faixa etária de 20 a 50 anos (53,8%. A neurocisticercose foi a forma mais freqüente e seu elevado percentual (91,5% foi atribuído às características da população estudada. Apesar do recente desenvolvimento da tecnologia diagnostica e terapêutica específicas, o tempo de permanência hospitalar médio foi de 35 dias e a letalidade média de 14,6%, apontando para a necessidade de medidas profiláticas através de programas de saúde pública.In this retrospective study of 126,968 in-patients at the Hospital das Clínicas of S. Paulo Medical School, S. Paulo, from 1979 to 1985, cysticercosis was diagnosed in 260 (0.2% of them Epidemiological data obtained from these 260 patients showed a dose distribution with regard to sex, and the age group from 20 to 50 years old was the most affected (53.8%. Neurocysticercosis was the most frequent and the high rate (91.5% was understood to be due to the characteristics of specific the patients studied. Despite the recent development of the diagnostic and therapeutic technology, the average length of hospitalization was 35 days and the rate of lethality 14.6%, pointing to the need for preventive measures on the part of public health programs.

  6. Avaliação de lâminas de colpocitologia oncótica previamente diagnosticadas como ASCUS: comparação interensaio e interobservadores

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    Souza José Helvécio Kalil de

    2004-01-01

    Full Text Available OBJETIVO: avaliar a existência de discordância intra e intercitopatologistas nas análises de lâminas de colpocitologias oncóticas que haviam recebido previamente o diagnóstico de células epidermóides atípicas de significado indeterminado (ASCUS e o grau dessa discordância. MÉTODOS: estudo transversal no qual foram analisadas 50 lâminas de colpocitologias oncóticas coletadas no mês de novembro de 2000 no município de Contagem e com diagnóstico prévio de ASCUS. Elas foram analisadas e classificadas por quatro citopatologistas, de acordo com as alterações propostas na primeira revisão de Bethesda, em 1991 (normal, alteração atrófica, alteração inflamatória, sugestiva de lesão de baixo grau, sugestiva de lesão de alto grau, sugestiva de carcinoma invasor, outros. Após a primeira análise, as lâminas foram novamente numeradas, de maneira aleatória, e entregues aos mesmos citopatologistas para novo exame. Foi utilizado o teste de kappa e sua especificação pontual, o kappa ponderado, para análises dos resultados. RESULTADOS: observaram-se graus bastante distantes de concordância entre diferentes análises do mesmo citopatologista, variando de 7,8 a 74,4%, (teste kappa. Quando foi instituído um peso para cada grau de discordância, os valores desse teste se elevaram, passando de 16,1% para o citopatologista A a 81,08% para o citopatologista B. Em relação às análises comparativas realizadas entre observadores distintos, os valores obtidos foram de 50,6% para o kappa e 63,4% para a sua variação pontual. CONCLUSÕES: a presente avaliação confirma a existência de subjetividade nos laudos citopatológicos de ASCUS, além de critérios imprecisos empregados pelo mesmo observador para obtenção desses resultados.

  7. Infecção diagnosticada em diabéticos durante internação hospitalar Infection in diabetics during inpatient care

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    L.G.K. de Aguiar

    1997-12-01

    Full Text Available OBJETIVO. Analisar o perfil de processos infecciosos em diabéticos internados em um hospital geral. MATERIAL E MÉTODOS. Foram selecionados, retrospectivamente, 233 prontuários de diabéticos no período de setembro a novembro de 1990. Num total de 38 (16,3% pacientes com infecção, 76,3% (n = 29 eram do sexo feminino, com média de idade de 58,9 ± 15,3 anos, duração do diabetes de 10,8 ± 9,1 anos e predomínio do diabetes melito tipo II na amostra (86,3%, n = 33. RESULTADOS. O principal motivo de internação foi a doença macrovascular de extremidades (42%. Quarenta processos infecciosos foram estudados (dois pacientes apresentavam infecção em dois sítios. Foram realizadas culturas em 77,5% dos casos, não tendo sido observado predomínio de nenhum germe, mesmo nos diferentes sítios. A infecção urinária foi a mais freqüente (55%, n = 22, p BACKGROUND. To analyse the infectious diseases of inpatient diabetics in a general hospital. MATERIAL AND METHODS. We selected retrospectively 233 records of diabetics admitted during September, October and November 1990. There were 38 (16.3% patients with infection, age 58.9 ± 15.3 years, 29 (76.3% were female, duration of diabetes were 10.8 ± 9.1 years and 86.3% (n = 33 were possibly DM type II. RESULTS. Peripheral macrovascular disease was the main cause of admission (42%. Forty infectious processes were analysed (two patients had two sites of infection. Cultures were performed in 77.5% of the cases and no microorganism predominated, even when different sites of infection were analysed. Urinary tract infection were the most frequent one (55%, n = 22, and 86.4% (n = 19 of them were observed in female. Pulmonary infections accounted for 71.4% of the cases of sepsis which occurred in 18.4% (n = 7 of our population. All patients with sepsis died. CONCLUSION. Considering infections a worsening factor for diabetic patients we could conclude that it is important to perform some prophylatic measures to avoid them.

  8. Enfermedad celiaca materna no diagnosticada y riesgo de tener hijos con bajo peso al nacimiento Maternal non-diagnosed celiac disease and risk of low birth weight

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    G. Solís Sánchez

    2008-06-01

    Full Text Available Objetivo: conocer la prevalencia de enfermedad celiaca en madres de neonatos mayores y menores de 2.500 gramos de peso al nacimiento. Pacientes: sujetos: casos: madres de neonatos menores de 2.500 g al nacimiento. Controles: madres de neonatos mayores de 2.500 g al nacimiento. Un control por cada caso. Instrumentalización: encuesta clínico-epidemiológica y serología celiaca. Métodos: estudio caso-control. Ámbito: mujeres del Área Sanitaria V (Gijón del Principado de Asturias que den a luz en el Hospital de Cabueñes. Resultados: se analizaron 1.103 mujeres: 577 madres de niños menores de 2.500 g y 526 madres de niños mayores de 2.500 g. Se diagnosticaron 4 casos de celiaquía, 2 en cada grupo. De las 4 madres, 3 dieron a luz a niños a término (1 caso cada 235 madres, prevalencia 0,42% y 1 dio a luz a un niño prematuro (1 caso cada 389 madres, prevalencia 0,26%. Dos madres dieron a luz a niños de peso adecuado para su edad gestacional (1/419 madres, prevalencia 0,24% y 2 madres dieron a luz niños de bajo peso para su edad gestacional (1/132 madres, prevalencia 0,75%. La odds ratio para peso menor de 2.500 g al nacimiento fue 0,91 (IC 95% 0,12-6,49, para prematuridad 0,61 (IC 95% 0,06-5,89 y para bajo peso para su edad gestacional 3,19 (0,44-22,79. Conclusiones: la prevalencia de enfermedad celiaca en mujeres fértiles de Gijón es de un caso cada 275 madres (prevalencia 0,36%, sin que hayamos encontrado diferencias entre los dos grupos estudiados.Aims: in order to know the prevalence of celiac disease in mothers with newborns weighing less or more than 2,500 g at birth we carried out a case-control study. Patients: mothers of newborns in Cabueñes Hospital. Case group: Mothers with babies weighing less than 2,500 g at birth. Controls: Mothers with babies weighing more than 2,500 g at birth. One control for each case. Methods: epidemiological and clinical interviews, and celiac disease serology. Results: we studied 1103 women: 577 cases and 526 controls. We diagnosed 4 celiac disease cases, 2 in the case group and 2 in the control group. These 4 mothers had 3 term newborns (1 case in each 235 mothers; prevalence 0.42% and 1 preterm newborn (1 case in each 389 mothers; prevalence 0.26%. Two cases had babies with adequate birth weight for their gestational age (1 case in each 419 mothers; prevalence 0.24% and two cases had babies with low birth weight for their gestational age (1 in each 132 mothers; prevalence 0.75%. The odds ratio for low birth weight was 0.91 (95% CI: 0.12-6.49, the odds ratio for preterm birth was 0.61 (95% CI: 0.06-5.89, ad the odds ratio for low birth weight for gestational age was 3.19 (95% CI: 0.44-22.79. Conclusions: the prevalence of celiac disease in fertile women in our geographic area was 0.36% (1 case in each 275 mothers, and no differences were found between study groups.

  9. Prevalencia de enfermedad cardiovascular en personas recién diagnosticadas de diabetes mellitus tipo 2 Cardiovascular disease prevalence in recent diagnosed type 2 diabetic patients

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    Manuel Mata-Cases

    2009-04-01

    Full Text Available Objetivo: Conocer la prevalencia de la enfermedad cardiovascular en el momento del diagnóstico de la diabetes mellitus tipo 2. Métodos: Estudio observacional retrospectivo realizado en un centro de atención primaria urbano entre 1991 y 2000. Revisión de las características clínicas, factores de riesgo y enfermedad cardiovascular el año del diagnóstico de diabetes. Se excluyeron los pacientes sin glucemias previas al diagnóstico. Se realizó un análisis de regresión logística para identificar las variables asociadas a la presencia de eventos cardiovasculares. Resultados: De los 598 nuevos casos de diabetes diagnosticados se analizaron los 487 que tenían valores previos de glucemia (media de edad [desviación estándar]: 60,4 [10,9] años; un 53% eran mujeres. La prevalencia de factores de riesgo cardiovascular fue: obesidad 61,1%, hipertensión arterial 71,9%, hipercolesterolemia 52%, hipertrigliceridemia 35,3% y tabaquismo actual 24% o previo 16,6%. El 96,9% tenía algún factor de riesgo cardiovascular y el 53,4% tres o más. Un total de 78 pacientes presentaron enfermedad cardiovascular anterior o detectada durante el primer año de diagnóstico (16%; intervalo de confianza del 95%[IC95%]: 12,8-19,3; varones 21,4% y mujeres 11,2%. La prevalencia de enfermedad cardiovascular aumentó con el número de factores de riesgo cardiovascular. El análisis de regresión logística mostró una asociación de la enfermedad cardiovascular y la edad >55 años (odds ratio [OR]=2,91; IC95%: 1,46-5,80, el tabaquismo (OR=2,28; IC95%: 1,15-4,51 y los valores de hemoglobina glucosilada (HbA1c >7% (OR=1,85; IC95%: 1,10-3,1. Conclusiones: Se observa una elevada prevalencia de factores de riesgo y enfermedad cardiovascular en el momento del diagnóstico de la diabetes; la edad, el tabaquismo y la HbA1c son las variables relacionadas con la enfermedad cardiovascular.Objective: To determine the prevalence of cardiovascular disease at diagnosis of type 2 diabetes mellitus. Methods: Retrospective observational study in an urban primary health care centre between 1991 and 2000. Review of clinical patient characteristics, cardiovascular disease and risk factors, in the year of diabetes diagnosis. Patients without any glycaemia recorded before diagnostic were excluded. Logistic regression was done to identify the variables associated to cardiovascular events. Results: From 598 cases of diabetes diagnosed, 487 with previous glycaemia were included for the analysis (mean age [SD], 60.4 [10.9]; 53% women. The prevalence of cardiovascular risk factors was: obesity 61.1%, hypertension 71.9%, hypercholesterolemia 52%, hypertriglyceridemia 35.3% and present or previous smoking habit (24 and 16,6%. 96.9% of them presented at least one of the studied cardiovascular risk factors and 53.4% three or more. 78 patients (16%; CI95%: 12.8-19.3 had cardiovascular disease before or during the first year of diagnosis (men 21.4% and women 11.2%. The prevalence of cardiovascular disease increased progressively with the number of cardiovascular risk factors. The significant predictive variables of cardiovascular disease (logistic regression were: age >55 years (OR=2.91; CI95%: 1.46-5.80, smoking habit (OR=2.28; CI95%: 1.15-4.51 and HbA1c >7% (OR=1.8; CI95%: 1.1-3.1. Conclusions: A high prevalence of cardiovascular disease and cardiovascular risk factors at diabetes diagnosis was observed. Age, smoking habit and elevated glycated haemoglobin were the variables related to cardiovascular disease.

  10. Kıbrıs Mülkiyet Tartışmasına Taşınmaz Mal Komisyonu Açısından Bir Bakış Cyprus Property Dispute through the Glance of Immovable Property Commission

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    Derya ÖZVERİ

    2013-07-01

    erçevesindetanımlamak amaçlanmaktadır. Ardından Kıbrıs’ta Türk ve Yunantarafların mülkiyet tartışmasına bakış açılarını da ele alınacaktır. İkitarafında müzakare masasında çok esneme payı bırakmadıkları bubakış açıları birbirinden çok farklı bir yapı da olması, uzlaşınınoluşabilmesini olanaksızlaştırdığından bu argümanlar daha da önemkazanmaktadır. Anlaşmazlığın taraflardan biri olan Türk tarafi ikibölgelilik,Yunan tarafı ise insan hakları argümanları üzerinden konuyayaklaşmaktadır. Taraflar tezlerini bu yönde savunurken, bu çalışmaAvrupa Insan Haklari Mahkemesi´nin iki önemli karari ile (LoizidouTürkiye´ye Karşı ve Xenides-Arestis Türkiye‘ye Karsi kurulmasinasebebiyet verdiği ve kararları ile bir iç hukuk yontemi olaraktüketilmesini ön-kosul olarak gösterdiği Tasinmaz Mal Komisyonu´nuincelemeye çalışacak ve artık görüşme masasında kemikleşmiş bir konuhaline gelmiş, adanın mülkiyet sorununa yeni bir umut ışığıolabileceğini tartışmayı amaçlamaktadır.

  11. External hydrocephalus (benign extra-axial collections of infancy) - review of 15 cases; Hidrocefalia externa colecao extra-axial benigna da infancia - revisao de 15 casos

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    Machado Junior, Marcos Alberto da Costa; Matos, Paulo Engracio de; Barbosa, Veronica Aline [Fundacao Monte Tabor, Salvador, BA (Brazil). Hospital Sao Rafael. Servico de Bioimagem; Vieira, Naiara Argollo [Hospital Salvador, BA (Brazil); Vieira, Lauro Conceicao Nascimento [Fundacao Monte Tabor, Salvador, BA (Brazil). Hospital Sao Rafael. Servico de Ressonancia Magnetica; Puglio, Nadja; Bacelar, Aroldo [Fundacao Monte Tabor, Salvador, BA (Brazil). Hospital Sao Rafael

    1997-03-01

    The authors studied 15 cases of external hydrocephalus over a 7-year period (September 1987 to May 1995). External hydrocephalus is a condition in which infants with rapidly enlarging heads are found to have a MRI showing widening of subarachnoid space with mild or no ventricular dilatation. Some of the MRI were compared with those of patients with cerebral atrophy and some etiopathogenic hypothesis are presented. These findings indicate that external hydrocephalus is an age-related self-limited condition occurring in infants with open cranial sutures and that it usually resolves without intervention after the second or third year of age. (author) 21 refs., 4 figs.

  12. Wicket spikes: a case-control study of a benign eletroencephalografic variant pattern "Wicket spikes": estudo de variante eletrográfica benigna

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    MARCUS SABRY AZAR BATISTA

    1999-09-01

    Full Text Available Wicket spikes (WS are a benign eletroencephalogram (EEG variant, seen mainly in adults, during somnolence, in the temporal regions, in many clinical situations. WS can appear in trains or isolatedly, sometimes being difficult to differentiate from epileptiform activity. We reviewed 2,000 EEG's, found 65 with WS (3.25% and compared them with 65 normal EEG without WS. There was statistically significant (SS association between WS and age over 33; adolescent age was correlated to absence of WS and age over 65, to the presence of WS; there was an inverse correlation between WS and epilepsy, related to differences in age; a SS association with cerebrovascular disorders disappeared after controlling for age; a SS correlation with headache was also related to age; female predominance was not SS. There was a great variety of clinical situation associated with WS. We conclude that WS are a inespecific normal variant of the EEG that is age-related.As Wicket spikes (WS são um padrão benigno, variante da normalidade do eletrencefalograma (EEG, vistas principalmente em adultos, durante a sonolência, nas regiões temporais, em situações clínicas variadas. WS aparecem em "trens" ou isoladamente, podendo ser difícil diferenciá-las de atividade epileptiforme. Nós revisamos 2.000 EEG e encontramos 65 com WS (3,25% e os comparamos a 65 EEG 's normais sem WS. Encontramos associação estatisticamente significante (ES entre WS e idade acima de 33 anos; adolescência e ausência de WS e idade acima de 65 e presença de WS. Houve correlação inversa entre WS e epilepsia, explicada por diferenças nas médias de idade. A correlação ES entre WS e doença cerebrovascular desapareceu após controlarmos a idade. A correlação ES a cefaléia dependeu de sua relação à idade. A predominância do sexo feminino não foi ES. Houve maior variedade de situações clínicas associadas a WS. WS são uma variante normal do EEG, idade-relacionada.

  13. Entrevistando as famílias de recém-nascidos mal-formados como proposta de avaliação e de intervenção de enfermagem - DOI: 10.4025/actascihealthsci.v26i1.1646 Interviewing the families of sick newborn babies as a proposal of - DOI: 10.4025/actascihealthsci.v26i1.1646

    Directory of Open Access Journals (Sweden)

    Dirce Laplaca Viana

    2004-04-01

    Full Text Available Trata-se de um estudo que buscou meios para entender como lidar com a família que vivenciou a notícia de ter um recém-nascido mal-formado. A entrevista ocorreu em um hospital público de São Paulo, em novembro de 2002, utilizando-se o Modelo Calgary de Avaliação e Intervenção na Família (MCAF/MCIF. O estudo mostrou a necessidade de intervenções construídas com a família para minimizar o impacto da notícia e para favorecer espaço para expressão de sentimentos e resolução da crise. O papel do enfermeiro como membro da equipe interdisciplinar é tentar efetivar o trabalho de ajuda à família de forma precoce, quando esta vive a difícil experiência de ter uma criança especial. A intervenção visa atuar com a família a partir da detecção do problema, utilizando a escuta ativa da comunicação verbal e não-verbal na tentativa de compreensão da situação e atuar como facilitador do processo de resolutividade da crise vivenciada.This paper is based on a study that searched ways to understand how to deal with the family who experienced the news of a sick newborn. The interview was performed in a hospital located in São Paulo, Brazil, in November of 2002 and it used the Calgary Model of Assessment and Intervention in Family (CMAF/CMIF. This study showed the need for intervention with the family to minimize the impact of receiving the news of a sick newborn, and to provide support through a conversation for resolution of the problem. The function of the nurse is to try to perform a precocious work with the family, facing the difficult experience of having a special child. The intervention aims to help the family to solve the problem, listening to the verbal and not verbal communication, searching to understand the situation with the family.

  14. Uma revisão sobre depressão como fator de risco na Doença de Parkinson e seu impacto na cognição Revisión sobre la depressión como factor de riesgo en el Mal de Parkinson e impacto sobre la cognición A review of depression as a risk factor in Parkinson's disease and the impact on cognition

    Directory of Open Access Journals (Sweden)

    Cláudia Débora Silberman

    2004-04-01

    utilizem critérios diagnósticos definidos e com amostras representativas da população podem trazer esclarecimento sobre o assunto.OBJETIVOS: Este trabajo tiene dos objetivos: 1 Examinar el impacto de la depresión sobre la cognición en el Mal de Parkinson (MP. 2 Examinar el papel de la depresión como factor de riesgo tanto para el MP como para trastorno cognoscitivo en el MP. METODOLOGÍA: Revisión de la literatura internacional (Medline, de artículos clínicos, seccionales, prospectivos y de caso control evaluando la función cognoscitiva de Parkinsonianos con y sin depresión, entre 1967 y 2003. Palabras clave: Mal de Parkinson, Depresión y Cognición. RESULTADOS: Los trabajos sobre el impacto de la depresión en la cognición de parkinsonianos presentan afirmaciones divergentes. Cinco artículos concluyen que hay impacto e cuatro no confirman esos datos. Puede afirmarse que la depresión es un factor de riesgos para MP así como el MP es un factor de riesgo para la depresión. No en tanto, ninguna definición fue posible en lo que se refiere a la depresión como factor de riesgo para trastornos cognoscitivos en parkinsonianos. Se observa que los datos sobre a prevalencia de la depresión y déficit cognoscitivo en el MP son inconclusivos con grande margen porcentual entre los autores. La depresión en parkinsonianos está asociada con el avance de la gravedad del MP, estado avanzado de Hoehn y Yahr, puntuación alta en la Unified Parkinson's Disease Rating Scale (UPDRS ocurrencia de caídas, baja puntuación en el Mini Examen del Estado Mental (MEEM y en la escala de Schwab y England, déficit cognoscitivo, bradykinesia axial, alteraciones en el caminar y en el balance, edad más avanzada, sexo femenino y presencia de alteración del pensamiento. CONCLUSIÓN: La interacción entre la depresión y MP es compleja y bi-direccional. La depresión es un factor de riesgo para MP así como MP es un factor de riesgo para la depresión. Es imposible trazar un perfil mas

  15. Amaç ve Beklenti Karşısında Karşılaştırmalı Edebiyatın Tanı(MSal Krizine İlişkin Birtakım Tartışmalı Saptamalar Some Argumentative Determinations Regarding Diagnostic/Definitional Crisis Of Comparative Literature In Terms Of Accordance With Its Purpose And Expectation

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    Abdulhakim TUĞLUK

    2013-09-01

    Full Text Available Comparison which possesses the characteristics of critic in linewith its purposes and ambitions keeps on its actuality and differenceperception because of its argumentative position within the science ofliterature. “Comparative Literature Science” which has become effectivein literature argumentations in recent years in Turkey has not beenable to make its identity and conceptual entity acceptable, yet. Not onlythe uncertainties in the definition, but also some problems in practicekeep the questions against comparative literature in a certain level.There are also some uncertainties whether it is a method or a science initself as well as the acceptability of it by national men of literature.Comparison, which is seen as easy to do at first in terms of feasibility,shows itself as a complex process when the literal and aestheticmissions attributed by the concept to it are taken into consideration.This complexity becomes a crisis in which there are many questionswhen it is faced with diagnostic and definitive problems. On the otherhand, West-centered perception of the comparative literature and itsinternational face embracing the concept of „world literature‟(Weltliteratur make global scale expectations committed by the conceptmore argumentative rather than meeting these expectations. In thisstudy, the main starting point is gaining a certain point of view to theidentity confusion of comparative literature and establishing a generalargumentation basis. The purpose of this study is revealing somecomplex points in theory and practice considering existential problemsof comparative literature and bringing some expansion to somehandicaps regarding essence of the comparative literature. Amaç ve hedefleri doğrultusunda bir eleştiri türü niteliği taşıyan karşılaştırma, edebiyat bilimi içerisindeki tartışmalı konumu nedeniyle güncelliğini ve farklılık algısını sürdürmektedir. Türkiye‟de, son yıllarda, edebi tart

  16. Survival of a cohort of women with cervical cancer diagnosed in a Brazilian cancer center Sobrevida de mujeres con cáncer de cuello uterino diagnosticadas en un centro brasileño Sobrevida de mulheres com câncer de colo uterino diagnosticadas em um centro brasileiro

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    Claudio Calazan do Carmo

    2011-08-01

    Full Text Available OBJECTIVE: To assess overall survival of women with cervical cancer and describe prognostic factors associated. METHODS: A total of 3,341 cases of invasive cervical cancer diagnosed at the Brazilian Cancer Institute, Rio de Janeiro, southeastern Brazil, between 1999 and 2004 were selected. Clinical and pathological characteristics and follow-up data were collected. There were performed a survival analysis using Kaplan-Meier curves and a multivariate analysis through Cox model. RESULTS: Of all cases analyzed, 68.3% had locally advanced disease at the time of diagnosis. The 5-year overall survival was 48%. After multivariate analysis, tumor staging at diagnosis was the single variable significantly associated with prognosis (pOBJETIVO: Evaluar la sobrevida global de mujeres con cáncer de cuello uterino e identificar factores pronósticos relacionados. MÉTODOS: Todos los 3.341 casos tratados en el Instituto Nacional de Cáncer, Rio de Janeiro, Sureste de Brasil, entre 1999 y 2004 fueron seleccionados y sus datos clínicos, anatomo-patológicos y de seguimiento fueron colectados. Se utilizaron la curva de Kaplan-meier y el modelo de Cox par evaluación de la sobrevida y para análisis logística múltiple, respectivamente. RESULTADOS: De los casos estudiados, 68,3% presentaban enfermedad localmente avanzada. La sobrevida en cinco años fue de 48%. Posterior al análisis múltiple, el estadio clínico al diagnóstico fue la única variable significativamente asociada con el pronóstico (pOBJETIVO: Avaliar a sobrevida global de mulheres com câncer de colo uterino e identificar fatores prognósticos relacionados. MÉTODOS: Todos os 3.341 casos tratados no Instituto Nacional de Câncer, Rio de Janeiro, RJ, entre 1999 e 2004 foram selecionados e seus dados clínicos, anatomo-patológicos e de seguimento foram coletados. Foram utilizados a curva de Kaplan-Meier e o modelo de Cox para avaliação da sobrevida e para análise logística múltipla, respectivamente. RESULTADOS: Dos casos estudados, 68,3% apresentavam doença localmente avançada. A sobrevida global em cinco anos foi de 48%. Após análise múltipla, o estádio clínico ao diagnóstico foi a única variável significativamente associada com o prognóstico (p<0,001. Mortalidade e o estádio clínico da doença apresentaram efeito dose-resposta, variando de 27,8 por 1.000 casos-ano a 749,6 por 1.000 casos-ano em mulheres com estádio I e IV, respectivamente. CONCLUSÕES: Os resultados mostram que a detecção precoce por meio de programas de prevenção é fundamental para aumentar a sobrevida em câncer cervical.

  17. Mal du siècle et mal du lieu : bovarysme et romantisme mêlés dans les deux grands romans modernes de Flaubert

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    Philippe Chardin

    2010-01-01

    Full Text Available Cet article tente, à partir d’une comparaison d’ensemble entre les deux grands romans modernes de Flaubert, Madame Bovary et L’Éducation sentimentale, et d’une superposition d’exemples significatifs empruntés à chacun d’eux, de montrer que la série des contrastes qui viennent tout de suite à l’esprit ne doit pas dissimuler des variations subtiles autour des mêmes schémas narratifs et des mêmes paysages psychiques : aussi bien pour ce qui est du pôle négatif des ridicules (« bovarysme » impénitent de Frédéric et des infortunes (analogies entre les épreuves traversées, notamment en matière d’« éducation sentimentale » que pour ce qui est du pôle du positif — plus implicite chez Flaubert — incluant une sorte de principe de réhabilitation partielle des « premiers plans » et la permanence de tout un romantisme de la singularité, de la révolte, de l’élection par le malheur, de la passion, du désir.With a global comparison between Flaubert’s two chief modern novels, Madame Bovary and L’Éducation sentimentale, and a superposition of suggestive examples taken from both of them, this article intends to prove that the sequence of contrasts that firstly appear must not conceal the subtle variations on the same narrative patterns and the same psychological climates. We can notice this phenomena as well as for the negative poles of ridiculous features (Frederic’s impenitent “bovarysme” and misfortunes (analogies between the trials that have to be faced by the heroes — especially those of the “sentimental journey”, as for the positive pole — more implicit in Flaubert’s prose — that implies a kind of partial rehabilitation principle of the main characters, and the persistence of romanticism, a whole romanticism with singularity, revolt, election through unhappiness,  passion and desire.

  18. Pensar el mundo y actuar en el mundo. Del mal radical a la banalidad del mal en el pensamiento de Hannah Arendt

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    Stefania Fantauzzi

    2003-01-01

    Full Text Available These pages prove how A Raport on the Banality of Evil forces Arendt to re-think the category of Radical Evil, in which she had based The Origins of Totalitarism. She now has to use a new interpretative criteria, based on the idea of the Banality of Evil, in which the author of a series of criminal acts is not a monster but a person unable to think. The notion of the Banality of Evil rises some discussion around the meaning of conscience, and the will that this meets in the responsibility of the individual, the tool to understand and fight Evil. These questions end up converging in the analysis of a basic moral issue, the judgment, which opens new perspectives on The Life of the Mind.

  19. Biología de Anopheles (Kerteszia neivai H., D. & K., 1913 (Diptera: Culicidae en la Costa Pacifica de Colombia: IV - Estructura etárea y transmisión de malaria Biologia do Anopheles (Kerteszia neivai H., D. & K., 1913 (Diptera: Culicidae na Costa do Pacífico Colombiano: IV - Estrutura etária e transmissão da malária Biology of Anopheles (Kerteszia neivai H., D. & K., 1913 (Diptera: Culicidae on the Pacific Coast of Colombia: IV - Age structure and malaria transmission

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    César Murillo B.

    1989-10-01

    Full Text Available Con el fin de determinar la dinamica de transmisión de malaria en el poblado de Charambirá (Chocó, Colombia, se estudió la estructura etárea de Anopheles neivai (reconocido vector en la Costa Pacífica con base en su estado gonadotrófico. Se recolectaron mosquitos intradomiciliarmente durante el crepúsculo vespertino con cebos humanos y aspiradores bucales. Los mosquitos recolectados se mantuvieron en cajas cilíndricas de cartón con papel humedecido y dispensadores alimenticios hasta su disección al día siguiente. De los 200 mosquitos disecados entre septiembre y octubre de 1986,68 (34% presentaban huellas de menos de tres oviposturas y los restantes (66% habían efectuado al menos tres oviposturas. La diferencia entre el primer grupo considerado como mosquitos "no infectivos" y el segundo considerado como los "potencialmente infectivos" fue altamente significativa (X² = 10,68; P = 0,001. El 1,5% de A. neivai estudiados presentaban huellas correspondientes a 10 oviposturas mostrando una marcada longevidad y múltiples alimentaciones sanguíneas. Los resultados sugieren que existe un alto riesgo de contraer malaria en Charambirá durante el crepúsculo vespertino.Com o intuito de determinar a dinâmica de transmissão da malária no povoado de Charambirá (Chocó, Colômbia, foi estudada a estrutura etária do mosquito Anopheles neivai (reconhecido vetor da Costa Pacífica com base em seu estado gonadotrófico. As coletas foram realizadas intradomiciliarmente no crepúsculo vespertino com isca humana e auxílio de tubos de sucção manual. Os mosquitos coletados foram mantidos em caixas cilíndricas de papelão, contendo papel umidecido e alimento. Dos 200 mosquitos dissecados entre setembro e outubro de 1986, 68 (34% apresentaram vestígios de menos de três oviposturas (oviposições e os demais (66% apresentavam, pelo menos, três ovipoturas. A diferença entre o primeiro grupo considerado como mosquitos "não infectantes" e o

  20. Congenital dermoid inclusion cyst over the anterior fontanel: report of three cases Cisto dermóide de inclusão congênita sobre a fontanela anterior: relato de três casos

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    Humberto Belem de Aquino

    2003-06-01

    Full Text Available Congenital dermoid inclusion cyst over the anterior fontanel (CDIC is an uncommon cystic lesion located over the anterior fontanel. It is a benign and curative lesion and most of the time, can be diagnosed at birth. From 1994 to 2001, three patients were operated with this kind of lesion and after reviewing the literature we found 229 cases and only 6 cases described in Brazil. Our objective in this study is to report three more cases.Cisto dermóide de inclusão congênita sobre a fontanela anterior (CDIC é lesão rara localizada na região da fontanela anterior. Trata-se de lesão benigna e curável que, na maioria das vezes, é diagnosticada no nascimento. De 1994 a 2001, três pacientes foram operados com este tipo de lesão e, através dos dados disponíveis na literatura, verificamos somente 229 casos descritos, apenas 6 descritos no Brasil, o que nos motivou a registrar mais três casos.

  1. Impacto de la disfunción temporomandibular sobre la dieta del paciente

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    María Martha Heinen Cortés

    2009-01-01

    Full Text Available La Disfunción de Articulación Temporo Mandibular (DATM es una patología que silenciosamente ha cobrado relevancia en la actualidad, pero que debido a su origen multifactorial y al amplio espectro de presentación clínica, es muchas veces mal diagnosticada. Sus signos y síntomas pueden influir importantemente en la capacidad masticatoria del paciente y por ello en el tipo de alimentos que elige, en la forma que los consume y en la forma que se realiza el subsecuente proceso de digestión. Es importante reconocer la entidad y brindar una orientación nutricional adecuada a los pacientes con DATM, así como tomar en cuenta la posible presencia de la entidad en pacientes que son tratados en otras áreas con apoyo nutricional.

  2. Síndrome de Rett. Presentación de un caso

    OpenAIRE

    Julio Padrón González; Ramón Pérez Mejías; Lidys Padrón Fernández; Leydis Padrón Fernández

    2012-01-01

    El síndrome de Rett es un trastorno neurológico de base genética. Afecta casi exclusivamente a niñas y mujeres; la incidencia estimada en la población general es de un caso por cada 10.000 mujeres, en su tipo clásico, es de 1 por cada 15. 000 nacimientos. Su diagnóstico es descriptivo, basado en un conjunto de signos y síntomas, pero no es etiológico; el tratamiento es sintomático y de apoyo. La enfermedad, frecuentemente, suele estar mal diagnosticada como autismo o parálisis cerebral. Deb...

  3. The (mal) adaptive value of mid-adolescent dating relationship labels.

    Science.gov (United States)

    Howard, Donna E; Debnam, Katrina J; Cham, H J; Czinn, Anna; Aiken, Nancy; Jordan, Jessica; Goldman, Rachel

    2015-06-01

    The aim of this study was to explore adolescent dating relationships through the prism of high school girls' narratives. We probed the contexts and meanings associated with different forms of dating to better understand the developmental significance of romantic relationships during adolescence. Cross-sectional, in-depth semi-structured interviews were conducted with 20 high school females. The analytic approach was phenomenological and grounded in the narratives rather than based on an a priori theoretical framework. Interviews were digitally recorded, transcribed verbatim by research staff and entered into ATLAS.ti 6, a qualitative data-management software package, prior to analysis. Teen relationships were found to vary along a Dis-Continuum from casual hookups to "official" boyfriend/girlfriend. There was a lack of consensus, and much ambiguity, as to the substantive meaning of different relationships. Labeling dating relationships seem to facilitate acquisition of important developmental needs such as identity, affiliation, and status, while attempting to manage cognitive dissonance and emotional disappointments. Findings underscore the confusion and complexity surrounding contemporary adolescent dating. Adolescent girls are using language and social media to assist them in meeting developmental goals. Sometimes their dating labels are adaptive, other times they are a cause of stress, or concealment of unmet needs and thwarted desires. Programs focused on positive youth development need to resonate with the realities of teens' lives and more fully acknowledge the complicated dynamics of teen dating relationships and how they are formalized, publicized and negotiated. PMID:25732189

  4. Opti mal Protocols to Expand Neural Stem Cells in Rotating Wall Vessel Bioreactor

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    1 IntroductionNeurodegenerative disorders exert on an enormous cost, both financially and emotionally, on afflicted individuals and their families for a long time. Fortunately, a neural stem cell (NSC) was identified in the adult central nervous system (CNS) and induced to proliferate untransformed in vitro~([1,2]). Neural stem cells are extremely primitive cells capable of self-maintenance and have the ability to generate large numbers of cells, including all of the phenotypes present in the adult CNS. The...

  5. Crowns to create esthetics for mal-aligned central incisors: a case report.

    Science.gov (United States)

    Savadi, Ravindra C; Savadi, Anupama R; Kumar, Preeti Satheesh

    2011-06-01

    This case report describes the smile design of crowded upper central anteriors in a female patient aged 25 years. The patient wanted the correction to be completed in a short period of time. A smile design schedule was drawn up involving root canal treatment of the central incisors and placing posts in both the teeth. All ceramic crowns were then fabricated to establish a very satisfactory and pleasing esthetics.

  6. Human milk as a source of tumor killing molecules. From MAL to HAMLET.

    OpenAIRE

    Mossberg, Anki

    2010-01-01

    HAMLET (Human alphalactalbumin made lethal to tumor cells), a complex between the partially unfolded alphalactalbumin and oleic acid, was discovered by serendipity when anti-adhesive properties of human milk were examined. HAMLET kills tumor cells but not healthy differentiated cells. Native alphalactalbumin (HLA) can be conveted to HAMLET by a two-step process including: 1) calcium ion removal inducing a teritary change of the protein structure. 2) incorporation of oleic acid into the apo...

  7. Mal-estar contemporâneo e conflitos entre vizinhos

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    Lidia Levy

    2011-01-01

    Full Text Available Este artículo enfoca los conflictos entre vecinos, hecho que se ha ido observando de manera creciente en la vida urbana de las grandes ciudades brasileñas. Partiendo de una discusión teórica sobre el malestar contemporáneo, que aparece marcado por la intolerancia y la violencia como formas de enfrentar las dificultades y los callejones sin salida interpersonales, el presente estudio tiene como objetivo revelar como las situaciones conflictivas son vividas por vecinos. El trabajo de campo fue realizado en el IV Juzgado Especial Criminal de Rio de Janeiro, y el análisis del contenido de los registros de ocurrencia de las quejas presentadas en la comisaría por los que están involucrados en procesos penales mostró que los conflictos de vecindad se caracterizan principalmente por tres aspectos: una reacción desproporcionada en relación al desacuerdo, la presencia de una sociabilidad reducida en los vínculos comunitarios, e individuos autocentrados en sus relaciones interpersonales. Se constató también que el Poder Judicial se convocaba para intervenir en asuntos hasta ahora considerados del ámbito privado y resolver conflictos cuyas tensiones eran, basicamente, ocasionadas por la intolerancia. Se verificó también la importancia de crear espacios de dialogo en que los involucrados en una controversia puedan exponer sus diferencias y elaborar juntos alternativas de solución al litigio. En este sentido, se sugiere que los desacuerdos entre vecinos puedan ser tratados de manera mas adecuada con un trabajo de mediación de los litigios, de naturaleza transdisciplinaria.

  8. Metafísica do irracional – mal radical em Schelling e Schopenhauer

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    Barboza, Jair

    2009-01-01

    Full Text Available Este artigo intenta mostrar as bases conceituais de uma metafísica do irracional em Schelling e Schopenhuaer, quando ambos os autores identificam na vontade a essência cega e irracional do mundo

  9. Metabolismo do ácido fólico na malária

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    Aymoré Vaz Pinto

    1983-06-01

    Full Text Available O estudo de 27 pacientes infectados pelo Plasmodium falciparum comparado com pessoas aparentemente sadias mostra: a diminuição do folato no soro dos pacientes infectados; b diminuição do folato sêrico nos primeiros 8 dias que seguiram ao tratamento, interpretados como sendo devido à mobilização pela eritropoiese compensadora; c folato eritrocítico normal.

  10. Dießmal Schlesien, Cleve, Sachsen, Pfalz und die Schweiz betreffend

    OpenAIRE

    Riem, Johann

    2006-01-01

    Teil von: Johann Riem's physikalisch-ökonomische Bienenbibliothek, oder Sammlung auserlesener Abhandlungen von Bienenwahrnehmungen und ausführliche Urtheile über ältere und neuere Bienenbücher / Johann Riem ; 3. Anhang bildet--> Riem, Johann: Johann Riem's Geprüfte Grundsätze der schlesischen Bienenpflege

  11. Atualidade e Produção de Mal-Estar

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    Katerine da Cruz Leal Sonoda

    2013-01-01

    Full Text Available Se pretende en este texto contemplar los efectos de la violencia en la subjetividad y el proceso salud-enfermedad de las personas, partiendo del supuesto de que la violencia (y el sentimiento de inseguridad en las ciudades puede provocar varios tipos de estrés, la somatización, malestar y, dependiendo de la gravedad, psicopatología. Por lo tanto, la violencia es considerada aquí un factor social de la enfermedad. Compartimos ideas de diferentes autores que, en sus análisis de la configuración actual, se refieren a la presencia de un "malestar" en la actualidad, lo que demuestra diferencias significativas en comparación con temporadas anteriores. La cultura de nuestro tiempo ha producido otras configuraciones psicopatológicas y también dio lugar a otros modelos de funcionamiento psíquico. Esto afecta, por la clínica directamente (en este caso psicoanalítico y en un campo más amplio, afecta a su propia gestión y los servicios públicos de salud, en la medida en que se presentan como las nuevas demandas de intervención, tratamientos y gastos. El objetivo de este trabajo es pensar en las formas contemporáneas del malestar en paralelo con las formulaciones psicoanalíticas de este concepto, frente a los estudios contemporáneos sobre psicopatologías y sus posibles formas de afectar la salud humana. El significativo aumento epidemiológico de ciertos trastornos psicológicos y psicosomáticos (como el Trastorno de Pánico, la Agarofobia, Estrés Postraumático, Depresión, Trastornos de ansiedad fóbica, entre otros ha llamado la atención de los profesionales de la salud pública, estableciendo un desafío a la atención y gestión de la salud. Una actitud profesional y ética de la atención de la persona que sufre reduce el riesgo de intervenciones iatrogénicas y gastos innecesarios.

  12. Web-marketing mix 4S v malé organizaci

    OpenAIRE

    Uhlíř, Petr

    2011-01-01

    The goal of this thesis is to evaluate whether application of the model of marketing promotion in the Internet based on the concept of web-marketing mix 4S in a small organization, sales-oriented professional machines and equipment for carpentry, plumbing and metal fabrication shop can achieve synergy and formulated key performance indicators. To achieve this goal is necessary to identify and describe technologies, tools, procedures and processes based on literature and publications that are ...

  13. André Gide et Les fleurs du mal de Baudelaire

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    Breda Cigoj Leben

    1975-11-01

    Full Text Available Andre Gide connut à fond le charme de la poésie vers 1885, à l'âge de seize ans, quand on lui permit de fouiller seul dans la bibliothèque de son père. A cette époque il tenait la poésie pour «la fleur et l'aboutissement de la vie» (J. II, 491. Ce fut Victor Hugo dont il apprit par creur nombre de pièces, ce fut surtout Henri Heine, lu d'abord dans la traduction et bientôt dans le texte, qui le boulversèrent profondément: J e me revois, étendu sur le tapis, à I'étrusque, au pied de la petite bibliothèque ouverte, en ce printemps de ma seizième année, tremblant à découvrir, a sentir s'éveiller et répondre à l'appel d'Henri Heine l'abondant priritemps de mon cceur( Ibid., 482.

  14. El papel de las facultades, ante el mal uso del castellano

    Directory of Open Access Journals (Sweden)

    Dr. Juan Jesús Pérez Pérez

    1998-01-01

    Full Text Available Es muy difícil poder hacer una prospección de cómo será el periodismo del próximo siglo, teniendo en cuenta los continuos y revolucionarios avances tecnológicos y la evolución de la sociedad. Sin embargo, a pesar de las innovaciones tecnológicas que ya estamos utilizando y que utilizaremos en el futuro, en esta sociedad científica o tecnológica y en esta sociedad de la información en la que estamos inmersos, si se puede prever que el uso de la lengua, junto con la imagen, seguirá siendo para los periodistas su herramienta básica de trabajo, cualquiera que sea el medio que se utilice, al margen de las innovaciones que se vayan introduciendo.

  15. Adaptation and mal-adaptation to ambient hypoxia; Andean, Ethiopian and Himalayan patterns.

    Directory of Open Access Journals (Sweden)

    Guoqiang Xing

    Full Text Available The study of the biology of evolution has been confined to laboratories and model organisms. However, controlled laboratory conditions are unlikely to model variations in environments that influence selection in wild populations. Thus, the study of "fitness" for survival and the genetics that influence this are best carried out in the field and in matching environments. Therefore, we studied highland populations in their native environments, to learn how they cope with ambient hypoxia. The Andeans, African highlanders and Himalayans have adapted differently to their hostile environment. Chronic mountain sickness (CMS, a loss of adaptation to altitude, is common in the Andes, occasionally found in the Himalayas; and absent from the East African altitude plateau. We compared molecular signatures (distinct patterns of gene expression of hypoxia-related genes, in white blood cells (WBC from Andeans with (n = 10, without CMS (n = 10 and sea-level controls from Lima (n = 20 with those obtained from CMS (n = 8 and controls (n = 5 Ladakhi subjects from the Tibetan altitude plateau. We further analyzed the expression of a subset of these genes in Ethiopian highlanders (n = 8. In all subjects, we performed the studies at their native altitude and after they were rendered normoxic. We identified a gene that predicted CMS in Andeans and Himalayans (PDP2. After achieving normoxia, WBC gene expression still distinguished Andean and Himalayan CMS subjects. Remarkably, analysis of the small subset of genes (n = 8 studied in all 3 highland populations showed normoxia induced gene expression changes in Andeans, but not in Ethiopians nor Himalayan controls. This is consistent with physiologic studies in which Ethiopians and Himalayans show a lack of responsiveness to hypoxia of the cerebral circulation and of the hypoxic ventilatory drive, and with the absence of CMS on the East African altitude plateau.

  16. Guidelines for practical use of MAL-PDT in non-melanoma skin cancer.

    Science.gov (United States)

    Christensen, E; Warloe, T; Kroon, S; Funk, J; Helsing, P; Soler, A M; Stang, H J; Vatne, O; Mørk, C

    2010-05-01

    Methyl aminolaevulinate photodynamic therapy is increasingly practiced in the treatment of actinic keratoses, Bowen's disease and basal cell carcinomas. This method is particularly suitable for treating multiple lesions, field cancerization and lesions in areas where a good cosmetic outcome is of importance. Good treatment routines will contribute to a favourable result. The Norwegian photodynamic therapy (PDT) group consists of medical specialists with long and extensive PDT experience. With support in the literature, this group presents guidelines for the practical use of topical PDT in non-melanoma skin cancer.

  17. MAL Daylight Photodynamic Therapy for Actinic Keratosis: Clinical and Imaging Evaluation by 3D Camera

    Directory of Open Access Journals (Sweden)

    Carmen Cantisani

    2016-07-01

    Full Text Available Non-melanoma skin cancer is the most common skin cancer with an incidence that varies widely worldwide. Among them, actinic keratosis (AK, considered by some authors as in situ squamous cell carcinoma (SCC, are the most common and reflect an abnormal multistep skin cell development due to the chronic ultraviolet (UV light exposure. No ideal treatment exists, but the potential risk of their development in a more invasive form requires prompt treatment. As patients usually present with multiple AK on fields of actinic damage, there is a need for effective, safe, simple and short treatments which allow the treatment of large areas. To achieve this, daylight photodynamic therapy (DL-PDT is an innovative treatment for multiple mild actinic keratosis, well tolerated by patients. Patients allocated to the PDT unit, affected by multiple mild−moderate and severe actinic keratosis on sun-exposed areas treated with DL-PDT, were clinically evaluated at baseline and every three months with an Antera 3D, Miravex© camera. Clinical and 3D images were performed at each clinical check almost every three months. In this retrospective study, 331 patients (56.7% male, 43.3% female were treated with DL-PDT. We observed a full clearance in more than two-thirds of patients with one or two treatments. Different responses depend on the number of lesions and on their severity; for patients with 1–3 lesions and with grade I or II AK, a full clearance was reached in 85% of cases with a maximum of two treatments. DL-PDT in general improved skin tone and erased sun damage. Evaluating each Antera 3D images, hemoglobin concentration and pigmentation, a skin color and tone improvement in 310 patients was observed. DL-PDT appears as a promising, effective, simple, tolerable and practical treatment for actinic damage associated with AK, and even treatment of large areas can be with little or no pain. The 3D imaging allowed for quantifying in real time the aesthetic benefits of DL-PDT’s increasing compliance.

  18. Discordia fratrum y el influjo historiográfico sobre la Historia mal llamada Silense

    Directory of Open Access Journals (Sweden)

    Isla Frez, Amancio

    2013-12-01

    Full Text Available The text wrongfully known as Historia Silensis drew on various historical writings of the past. Its debt to Sallust and the biographers of Charlemagne is not merely formal. The anonymous Leonese chronicler from the beginning of the 12th century constructed his historical explanation and legitimated his proposals on the basis of the experience provided by Sallust, Einhard and others. Particularly important among his many suggestions is the inevitability of the discordia fratrum.La erróneamente llamada Historia Silense recibió los influjos de algunas obras históricas del pasado. Su deuda con Salustio y los biógrafos de Carlomagno no es sólo formal. El anónimo autor leonés del siglo XII construyó su explicación histórica y legitimó sus propuestas merced a la experiencia proporcionada por Salustio, Eginardo y otros. Entre sus sugerencias destacamos la inevitabilidad de la discordia fratrum.

  19. Le temps de la fatigue : La gestion sociale du mal-être au travail

    OpenAIRE

    Loriol, Marc

    2000-01-01

    Il est de plus en plus courant aujourd'hui de se plaindre d'une " mauvaise fatigue " dont seraient responsables les conditions de vie modernes. L'ambition de ce livre est d'articuler une approche historique longue qui inscrit cette notion de mauvaise fatigue dans le processus de civilisation défini par Norbert Elias (l'autocontrôle des émotions et les nouvelles régulations s'accompagnent d'une individualisation et d'une autonomie qui rendent plus sensibles les défaillances individuelles) et u...

  20. Placebo, um mal-estar para a medicina: notícias recentes

    Directory of Open Access Journals (Sweden)

    Mônica Teixeira

    2008-12-01

    Full Text Available O artigo relata novos desdobramentos no debate médico a propósito do placebo e seus efeitos, relacionados à sua utilização na clínica médica e em ensaios clínicos de drogas e tratamentos.

  1. Cognitions as determinants of (mal)adaptive emotions and emotionally intelligent behavior in an organizational context.

    Science.gov (United States)

    Spörrle, Matthias; Welpe, Isabell M; Försterling, Friedrich

    2006-01-01

    This study applies the theoretical concepts of Rational Emotive Behavior Therapy (REBT; Ellis, 1962, 1994) to the analysis of functional and dysfunctional behaviour and emotions in the workplace and tests central assumptions of REBT in an organizational setting. We argue that Ellis' appraisal theory of emotion sheds light on some of the cognitive and emotional antecedents of emotional intelligence and emotionally intelligent behaviour. In an extension of REBT, we posit that adaptive emotions resulting from rational cognitions reflect more emotional intelligence than maladaptive emotions which result from irrational cognitions, because the former lead to functional behaviour. We hypothesize that semantically similar emotions (e.g. annoyance and rage) lead to different behavioural reactions and have a different functionality in an organizational context. The results of scenario experiments using organizational vignettes confirm the central assumptions of Ellis' appraisal theory and support our hypotheses of a correspondence between adaptive emotions and emotionally intelligent behaviour. Additionally, we find evidence that irrational job-related attitudes result in reduced work (but not life) satisfaction.

  2. Mal d'archive : on the growth of Gunter Demnig's Stolperstein-project.

    OpenAIRE

    Osborne, Dora

    2014-01-01

    In Archive Fever, Derrida opens a critical perspective on the status of the trace as that which remains with his reading of Gradiva, the Pompeian fantasy woman who is supposed to have left her singular toe-print in the ash of Vesuvius. This article returns to the figure of Gradiva as emblem for the non-coincidence of origin and trace, in order to outline the (increasingly troubling) archival aspects of Gunter Demnig's Stolperstein-project, a large-scale, decentralized memorial commemorating t...

  3. « La banalité du mal » selon Eduardo Pavlovsky

    Directory of Open Access Journals (Sweden)

    Isabelle Clerc

    2013-03-01

    Full Text Available Dans El señor Galíndez (1973 et Potestad (1985, le dramaturge argentin Eduardo Pavlovsky met en scène la figure d’un tortionnaire humain. Ces pièces bousculent la norme. Comment accepter en effet que la torture et l’enlèvement d’enfants durant la dictature argentine ne soient pas l’œuvre de monstres mais de gens ordinaires ? Nous nous proposons de voir les mécanismes de la rupture dans ces pièces, et d’en analyser la portée.

  4. An SEC/MALS Study of Alternan Degradation During Size-exclusion Chromatographic Analysis

    Science.gov (United States)

    The degradation of high molar mass polymers during size-exclusion chromatography (SEC) analysis has been a topic of interest for several decades. Should a polymer degrade during analysis, the accuracy of the molar mass (M) and architectural information obtained will be compromised. To this effect,...

  5. Variations around a head fever / Variaciones alrededor de un mal de cabeza

    OpenAIRE

    Bruno Mazzoldi

    2011-01-01

    Who would try to turn the pathological and healing cap in question without giving up Rimbaud disarray of the senses and the somaticdisorganization of Kierkegaard’s substitutes will have lost its head by desiring to make Derrida say or by leaving him say what he would make Deleuze say or would leave him say about the body without organs, with the help of capnomancy, art of divination through the movements of smoke, because, not any longer in front of a detruncation able to revoke whether the f...

  6. Vlastivědná mapa malého územního celku

    OpenAIRE

    Karlíková, Eliška

    2014-01-01

    Diplomová práce se zabývá analýzou mapového obsahu vybraných historických a současných kartografických děl, zobrazujících území Blovicka a tvorbou vlastivědné mapy této oblasti. V teoretické části je, kromě základů kartografie a vlastivědných map, také definováno a popsáno zájmové území. Praktická část obsahuje popis provedených analýz vývoje zeměpisných jmen, mapových znaků a krajiny a popis tvorby vlastivědné mapy Blovicka. Součástí práce jsou tabulky související s analýzami mapového obsahu...

  7. Recolectando palabras: Qate-Qate, el ave de mal agüero

    Directory of Open Access Journals (Sweden)

    Lourdes Chino Larico

    2006-12-01

    Full Text Available Según el padre Domingo Llanque Chana (cronista aymara, la cultura aymara surgió de los rezagos de la cultura Tiahuanaco, y es mucho más antigua que la misma cultura Inca. Debido a su gran resistencia y rebeldía nunca se dejo conquistar por los gobernantes del imperio Incaico, ni por los españoles durante la conquista. Otra teoría del cronista jesuita Ludovico Bertonio dice que la cultura aymara es el resultado de la fusión de los pequeños reinos Lupaka y Pakaje (Perú - Bolivia. Actualmente la zona aymara abarca la mayoría de las provincias del departamento de Puno en el Perú, y parte de La Paz y Cochabamba en Bolivia, como algunas regiones del norte de Argentina y Chile. La cultura aymara como sociedad ágrafa tiene en sus cuentos, mitos, creencias, leyendas, canciones, danzas, etc. leyes y normas que rigen las vidas de sus pobladores, como por ejemplo el mito del QATE-QATE.

  8. Household food access and child malnutrition: results from the eight-country MAL-ED study

    Directory of Open Access Journals (Sweden)

    Psaki Stephanie

    2012-12-01

    Full Text Available Abstract Background Stunting results from decreased food intake, poor diet quality, and a high burden of early childhood infections, and contributes to significant morbidity and mortality worldwide. Although food insecurity is an important determinant of child nutrition, including stunting, development of universal measures has been challenging due to cumbersome nutritional questionnaires and concerns about lack of comparability across populations. We investigate the relationship between household food access, one component of food security, and indicators of nutritional status in early childhood across eight country sites. Methods We administered a socioeconomic survey to 800 households in research sites in eight countries, including a recently validated nine-item food access insecurity questionnaire, and obtained anthropometric measurements from children aged 24 to 60 months. We used multivariable regression models to assess the relationship between household food access insecurity and anthropometry in children, and we assessed the invariance of that relationship across country sites. Results Average age of study children was 41 months. Mean food access insecurity score (range: 0–27 was 5.8, and varied from 2.4 in Nepal to 8.3 in Pakistan. Across sites, the prevalence of stunting (42% was much higher than the prevalence of wasting (6%. In pooled regression analyses, a 10-point increase in food access insecurity score was associated with a 0.20 SD decrease in height-for-age Z score (95% CI 0.05 to 0.34 SD; p = 0.008. A likelihood ratio test for heterogeneity revealed that this relationship was consistent across countries (p = 0.17. Conclusions Our study provides evidence of the validity of using a simple household food access insecurity score to investigate the etiology of childhood growth faltering across diverse geographic settings. Such a measure could be used to direct interventions by identifying children at risk of illness and death related to malnutrition.

  9. Návrh malé vodní nádrže

    OpenAIRE

    Galuška, Martin

    2016-01-01

    Práce se zaměřuje na vypracování zjednodušeného návrhu vodohospodářského a konstrukčního řešení v lokalitě Bezměrov. V části teoretické jsou stručně popsány základní funkční objekty nádrže. Samotná práce je pak založena na vyhodnocení morfologie terénu z dodaných podkladů ve formě vrstevnic a geologických sond a následném návrhu řešení suché retenční nádrže. V rámci výkresové části bude využito výstupů z programu PowerCivil, ve kterém bude pomocí digitálního modelu terénu vytvořeno směrové ře...

  10. Internetový marketing na příkladu malé organizace

    OpenAIRE

    Vaňáč, Ondřej

    2011-01-01

    The aim of this work is the analysis of current practices and techniques of Internet marketing. The work is divided into two parts. The theoretical part presents the current internet marketing tools, the optimal utilization is reflected in the practical part, which is carried out a comprehensive plan for internet marketing strategy with emphasis on SEO for start-up company in the field of accommodation and hospitable service. This is a company Penzion U Lišky, which offers accommodation in So...

  11. Mal tiempo, tiempo maligno, tiempo de subversión ritual. La temposensitividad agrofestiva invernal

    OpenAIRE

    Del Campo Tejedor, Alberto

    2006-01-01

    In the light of a number of festive, ritual, poetico-musical and literary expresions, from Andalusia and elsewhere, the author discusses time as lived by agrarian cultures: a syncretic time, resulting from the superposition of civico-political, religious and peasant calendars; a cyclic time, given the effects of astronomico-meteorological time on nature and the subsequent cultural response on both the instrumental dimension (the work in the fields) and the expresive dimension (the rituals and...

  12. Nasazení Google Apps for Work v malé firmě

    OpenAIRE

    Hrubý, Jakub

    2014-01-01

    This diploma thesis deals with a product Google Apps for Work as a cloud-based tool for businesses. The main idea of this work is to describe the offered service and to deploy it to a real company on the Czech market, belonging to the sector of small and medium-sized companies. The theoretical part is based on a literature review of technical books, articles, and other electronic sources. The subsequent description and evaluation of the implementation is based on real-world knowledge in deplo...

  13. Kreativní účetnictví malých podniků

    OpenAIRE

    Hübnerová, Eva

    2012-01-01

    The diploma thesis deals with the creative accounting of small enterprises in the Czech accounting practice. Natural effort of companies is a tax reduction. Therefore the techniques of creative accounting in the thesis are divided by whether the company is trying to manipulate the accounting data for tax or non-tax reasons. Theoretical description of techniques of creative accounting is completed cases of findings the tax offices. In conclusion of the thesis there are suggested possible solut...

  14. Analýza možností propagace malé firmy na internetu

    OpenAIRE

    Beránek, Jakub

    2013-01-01

    The bachelor thesis deals with the possibilities of promoting small business on the Internet and analyses the results of the different channels used to realize the advertising. Websites were created to a company. These internet pages are different from the competition on the website, for example you can book a massage. Advertising is realised using the following channels: PPC advertising, banners, SEO, Facebook, discount vouchers,... Although this is a specific product (massage, specializing ...

  15. Chronic aflatoxin exposure in children living in Bhaktapur, Nepal: Extension of the MAL-ED study

    Science.gov (United States)

    Fumonisin B1 (FB1) and aflatoxin B1 (AFB1) are toxic chemicals produced by molds. The molds that produce these two toxic chemicals are commonly found in corn and their co-occurence in corn has been demonstrated in many surveys. This study was conducted because it is suspected that exposure to eith...

  16. MAL Daylight Photodynamic Therapy for Actinic Keratosis: Clinical and Imaging Evaluation by 3D Camera.

    Science.gov (United States)

    Cantisani, Carmen; Paolino, Giovanni; Pellacani, Giovanni; Didona, Dario; Scarno, Marco; Faina, Valentina; Gobello, Tommaso; Calvieri, Stefano

    2016-07-11

    Non-melanoma skin cancer is the most common skin cancer with an incidence that varies widely worldwide. Among them, actinic keratosis (AK), considered by some authors as in situ squamous cell carcinoma (SCC), are the most common and reflect an abnormal multistep skin cell development due to the chronic ultraviolet (UV) light exposure. No ideal treatment exists, but the potential risk of their development in a more invasive form requires prompt treatment. As patients usually present with multiple AK on fields of actinic damage, there is a need for effective, safe, simple and short treatments which allow the treatment of large areas. To achieve this, daylight photodynamic therapy (DL-PDT) is an innovative treatment for multiple mild actinic keratosis, well tolerated by patients. Patients allocated to the PDT unit, affected by multiple mild-moderate and severe actinic keratosis on sun-exposed areas treated with DL-PDT, were clinically evaluated at baseline and every three months with an Antera 3D, Miravex(©) camera. Clinical and 3D images were performed at each clinical check almost every three months. In this retrospective study, 331 patients (56.7% male, 43.3% female) were treated with DL-PDT. We observed a full clearance in more than two-thirds of patients with one or two treatments. Different responses depend on the number of lesions and on their severity; for patients with 1-3 lesions and with grade I or II AK, a full clearance was reached in 85% of cases with a maximum of two treatments. DL-PDT in general improved skin tone and erased sun damage. Evaluating each Antera 3D images, hemoglobin concentration and pigmentation, a skin color and tone improvement in 310 patients was observed. DL-PDT appears as a promising, effective, simple, tolerable and practical treatment for actinic damage associated with AK, and even treatment of large areas can be with little or no pain. The 3D imaging allowed for quantifying in real time the aesthetic benefits of DL-PDT's increasing compliance.

  17. Strategie malých a středních podniků

    OpenAIRE

    Jehlička, Tomáš

    2015-01-01

    The goal of the master thesis is to execute a strategic analysis of Výzva 21 dní, s.r.o., considering the need of restructuring steps and proposal of corporate strategy for the company. The task of the theoretical part is to explain the basic terms of the strategic management in small and medium-sized enterprises. The practical part is devoted to a strategic analysis of the company Výzva 21 dní, s.r.o. The key methodologies used are Porter's five competitive forces analysis and PESTE analysis...

  18. PERSPECTIVES ON FUTURE EFL COMMUNICATIVE ENVIRONMENTS BY E-MAlL AND INTERNET IN CHINESE UNIVERSITIES

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    E-mail-assisted language teaching is at the fore-front of the advances in educational tools in EFLteaching.But is it possible to create EFL communica-tive environment by E-mail and Internet in Chineseuniversities?Can we totally adopt CA by E-mail andInternet in Western countries into Chinese universi-ties?It is evident that Completely transferring it toChinese educational context is irrational and will ulti-mately fail.Thus,success depends on reconciling E-mail-assisted EFL teaching with traditional Chineseapproaches.This paper is designed to make perspec-tives on this reconciliation,and presents some disad-vantages of using E-mail and Internet in teaching.

  19. Personální práce v malém podniku

    OpenAIRE

    Látalová, Silvie

    2010-01-01

    This thesis focuses on the topic of human resources management in a small business. The goal of the thesis is to analyze human resources management in a small business PAT, show their strengths and weaknesses and eventually suggest some corrective steps. In the theoretical part after the terms human resources management and small business are defined, the differences between human resources management in a small and in a large business are described as well as individual human resources activ...

  20. Ganándole la batalla al mal humor. Una propuesta didáctica

    Directory of Open Access Journals (Sweden)

    Sarah Díaz García

    2012-01-01

    Full Text Available En los últimos años, el aprendizaje de lenguas extranjeras ha llegado a ser una necesidad real tanto profesional como personal para todos nosotros como ciudadanos y como trabajadores. La enseñanza del español como lengua extranjera, que es el área de estudio en el que nos centraremos en el resto del presente artículo, ha evolucionado a medida que nuestra sociedad ha ido cambiando y adaptándose a los nuevos tiempos. Este cambio surgió con el Marco Común Europeo de Referencia para las Lenguas (MCER; pasamos de darle una máxima importancia a los aspectos puramente lingüísticos a abrirnos al hecho de que aprender un segundo idioma no es solo centrarnos en la gramática. La competencia comunicativa, por ejemplo, ha ido cobrando protagonismo en los últimos años; la idea de que un estudiante solo es competente en el uso de una lengua cuando utiliza la lingüística (pensemos en la gramática de forma correcta y siguiendo la norma ha caído en desaprobación para muchos. La realidad es que para que un alumno se considere competente en el uso de otra lengua que no sea la suya debe saber utilizar las técnicas y recursos pertinentes para poder comunicarse efectivamente con su interlocutor en un contexto real de habla.

  1. 7 CFR 1421.418 - Submitting MAL and LDP documentation to FSA.

    Science.gov (United States)

    2010-01-01

    ... COMMODITIES-MARKETING ASSISTANCE LOANS AND LOAN DEFICIENCY PAYMENTS FOR 2008 THROUGH 2012 Designated Marketing... itemize receipts, and other data, as required, or a pre-processed electronic file containing data...

  2. Saga do computador mal-amado Saga del ordenador malamado Saga of the unloved computer

    Directory of Open Access Journals (Sweden)

    Claudio de Moura Castro

    2010-09-01

    Full Text Available O que a tecnologia tem a oferecer para a educação é cada vez mais abundante, criativo e confiável. Seja nas tecnologias de imagem, nos computadores e nas suas combinações, a oferta é quase ilimitada. Não obstante, as escolas acadêmicas não conseguem usar com sucesso tais recursos. Há ampla evidência de que iniciativas bem focalizadas mostram resultados muito positivos. Contudo, tais sucessos não se generalizam e a maioria dos estudos mostra resultados pífios para os sistemas educativos como um todo. A sociologia da escola acadêmica e a tecnologia se enfrentam em batalhas em que saem perdendo os alunos. Não obstante, os computadores nas casas dos alunos tendem a melhorar o seu rendimento. Ainda mais admirável, a miríade de soluções educativas não-formais fazem excelente uso de todas as tecnologias.Lo que la tecnología tiene para ofrecerle a la educación es cada vez más amplio, creativo y confiable. La oferta es casi ilimitada, ya sea en tecnología de imagen, en variedad de ordenadores (computadoras o en sus diversas combinatorias. Sin embargo, los centros académicos no logran utilizarlos en forma exitosa. Hay amplia evidencia de que cuando las iniciativas están bien focalizadas resultan beneficiosas para los estudiantes. El problema es que tales resultados no se generalizan en los sistemas educativos. La consecuencia es que no mejora el rendimiento de los estudiantes. Es como si la sociología de la escuela estuviera en guerra con la tecnología. Por supuesto, los que pierden son los estudiantes. Pero, cuando los ordenadores están en los hogares de los estudiantes, su aprendizaje puede mejorar. Y más loable aún es que la educación no formal impulsa la tecnología educativa con gran éxito.What technology has to offer to education is ever more abundant, creative and reliable. Be it in the image technology, in the computers and in their combinations, the possibilities are almost endless. Nevertheless, academic schools fail to materialize the benefits one could expect from such resources. While there is ample evidence that well-focused initiatives show positive results on learning, this learning potential does not generalize for educational systems as a whole. School sociology is at odds with the modes of utilization that would make a difference. As a result, students lose. In contrast, computers in students' homes improve learning. Even more admirable, non-formal schooling modes have been using technology with ample success.

  3. Utshjonõi malõi, no pedant... / Sergei Maltsev, Mihhail Petrov

    Index Scriptorium Estoniae

    Maltsev, Sergei

    2001-01-01

    Vastukaja Sergei Issakovi retsensioonile "Jamõ i uhabõ "Revelskogo trakta" ajalehes "Vesti : Nedelja Pljus" Feb/16 lk. 24 Vladimir Illjashevitshi raamatust "Revelskii trakt : istorii o russkoi Pribaltike" : Tallinn, 2001

  4. Mal de Pott em Crianças de 15 Meses

    OpenAIRE

    de Miguel, Cristina; Ferreira, Gabriel; Miranda, Francisco; Oliveira, António; Geraldes, Amadeu; Seabra, Jorge; de Oliveira, Gonçalves

    2014-01-01

    A tuberculose da coluna vertebral descrita pela primeira vez por Percival Pott e desde então associada ao seu nome, é uma doença de desenvolvimento lento, caracterizada por dor, deformidade vertebral e por vezes paralisia.Um alto índice de suspeição, assim como um tratamento precoce e adequado são necessários na abordagem da tuberculose vertebral.Os autores apresentam um caso clínico de uma criança com 15 meses de idade com tuberculose vertebral, apresentando cifose e paraparesia no momento d...

  5. Lost in Search: (Mal-)Adaptation to Probabilistic Decision Environments in Children and Adults

    Science.gov (United States)

    Betsch, Tilmann; Lehmann, Anne; Lindow, Stefanie; Lang, Anna; Schoemann, Martin

    2016-01-01

    Adaptive decision making in probabilistic environments requires individuals to use probabilities as weights in predecisional information searches and/or when making subsequent choices. Within a child-friendly computerized environment (Mousekids), we tracked 205 children's (105 children 5-6 years of age and 100 children 9-10 years of age) and 103…

  6. The Earth in energy troubles; La Planete en mal d'energie

    Energy Technology Data Exchange (ETDEWEB)

    Pierret, Ch.; Carroue, L.; Goodchild, M.F.; Charvet, J.P.; Simon, A.; Ane, J.M.; Auburtin, E.; Barre, B.; Bonin, S.; Fumey, G.; Daviet, S.; Goupil, Ph.; Helfer, M.; Raison, J.; Velut, S.; Vidal, D.; Radvanyi, J.; Tapia, St. de; Pourtier, R.; Sebille-Lopez, Ph.; Clairet, S.; Poirson, A.C.; Guillaume, J.; Collignon, B.; Bauquis, P.R.; Brunel, S.; Guillaume, J.; Hourcade, B.; Marchand-Vaguet, Y.; Pitte, J.R.; Marchand-Vaguet, Y.; Laherrere, J.; Letourneau, M.; Lemarchand, N.; Beltran, A.; Bret, B.; Feckoua, L.; Helfer, M.; Lacoste, R.; Manzagol, C.; Tessier, F.; Vanneph, A.; Claessens, M.; Berdevet, M.; Tabeaud, M.; Laherrere, J.; Arnould, P.; Berque, A.; Brucher, W.; Deshaies, M.; Douguedroit, A.; Husson, J.P.; Lemartinel, J.; Mancebo, F.; Baron-Yelles, N.; Pitte, J.R.; Sede Marceau, J.H. de; Vigneau, J.P.; Tabeaud, M.; Fremont, A.; Crozet, Y.; Maupu, J.L.; Orfeuil, J.P.; Savy, M.; Viel, D.; Hammer, A.; Sanjuan, Th.; Lagarec, D.; Raillon, F.; Koninck, R. de; Bailly, A.; Bruneau, M.; Boulanger, Ph.; Bret, B.; Fournet-Guerin, C.; Hourcade, J.Ch.; Pitte, J.R.; Sanjuan, Th.; Verdeil, E.; Butler, S. de; Saint Germain, F.; Bouette, N.; Detot, A.; Caracchioli, Ph.; Bouette, N.; Smaghue, N.; Pousin, J.; Buysse, Ph.; Riallant, Y.; Durand, H.; Genter, A.; Dieulin, C.; Pronier, O.; Badea, A.; Tetart, F.; Genevois, S.; Leobet, M.; Angsthelm, B.; Calugaru, C.; Domergue, Ph.; Iacu, C.; Muntele, L.; Goodchild, M.F.; Costa, P

    2007-07-01

    This document gathers the available presentations (articles and transparencies) given at this annual meeting, the 2007 topic of which was the technological, geopolitical, economical, environmental, societal and development stakes of energy. 1 - technological stakes - which energies for the future: new energies, illusion or solution of the future; the Lorraine region, an energy land: strategies and stakes for a sustainable development; from China to Brazil: understanding the nuclear energy revival; hydroelectric power: renewable and sustainable energy; renewable energies and environment protection: the contribution of biofuels; wind power in Germany between success and contestation; 2 - geopolitical stakes - energy levier of power: the Gulf of Guinea hydrocarbons: between development and geopolitics; the complex evaluation of resources and reserves between technology, market and geopolitics; the new Bakou-Tbilissi-Ceyhan pipeline: what impacts for Turkey and the European Union; 3 - economical stakes - are public energy policies possible: the pro-alcohol program in Brazil; the surprising development of coal in the 21. century; natural gas: geo-economical and geopolitical stakes; exploitation of offshore platforms in Newfoundland: the new future of codfish island; tar sands of Alberta: promises and stakes of a 'Northern Arabia'; 4 - environmental stakes - energies responsible for the global warming: energy transformation and work in human societies; lessons learnt from the pre-industrial era: the limits of modern renewable energy sources; the energy policies in Europe: environmental constraints and geopolitical risks; reducing our energy consumption: a stake of the future; global warming and energy troubles; a territorial approach of energy, an answer to the 21. century challenges; the climate in an energy consuming world, debate and precautions; the Kyoto protocol through the geographical critics; 5 - society stakes - what energies for tomorrow's city: global design of transportation systems in Freiburg im Brisgau city (Germany); 6 - development stakes - access to energy; fatality or inequality: the energy appetite of China, between development and geopolitics; energy and health; wood fuel: the real energy crisis of the poorest southern countries; Madagascar: the lack of energy as a break to development; the challenges of the Three Gorges dam in China; geopolitics and electric power in Middle East and Lebanon; 7 - pedagogical courses: geography teaching using the map library of the French documentation; harvesting and criticizing the energy information coming from Internet; the Earth's energy troubles; petroleum in Africa, revealer of a development problem; petroleum, geopolitical stake of the present day world; the Penly nuclear power plant (Normandy, France); hydroelectric power in the Durance basin: some complex spatial stakes; wind power and land planning; the Earth's petroleum troubles; how petroleum fluxes can reveal the organization of worldwide trades; Picardie: a region in front of renewable energies; 8 - geomatics: wind farms and landscape; geothermal energy: potentialities, challenges and perspectives; Spot Image's projects of monitoring of hydrocarbon pollutions; geo-referenced databases for the agricultural and environmental management of Romania; virtual globes or educative geographical information systems: what is new for geography teaching; geo-portals: a scientific and technical tool; conflicts and petroleum, the Darfour example; the coal from Oltenie mining area (Romania): solution or puzzling problem; energy and society, which transportation policy; geo-history of petroleum in Romania; Citizens as sensors: the world of volunteered geography; the natural environment of the Danube delta. (J.S.)

  7. Võõrkeeleoskuse sertifikaat koolist kaasa / Nora Mals, Oleg Kravtšenko

    Index Scriptorium Estoniae

    Mals, Nora

    2006-01-01

    Tallinna Reaalkooli ja Keelekeskuse Puškin koostööst, mis annab võimaluse abiturientidele sooritada eri tasemega rahvusvahelisi teste, mille alusel keelekeskus väljastab riiklikud sertifikaadid, mida rahvusvaheliselt tunnustatakse

  8. Kultura jako faktor rozvoje malého města

    OpenAIRE

    Ziková, Dagmar

    2013-01-01

    The thesis explores the possibilities and expressions of culture as a factor that influences small town development (in this case the town of Zábřeh). The theoretical part defines basic concepts that refer to culture and related areas – small town definition, economic overlapping of culture and relation between culture and town development. The descriptive part shows the town of Zábřeh in detail and all its cultural manifestation. Material and non-material culture, cultural infrastructure, en...

  9. Audit v malém a středním podniku

    OpenAIRE

    Marešová, Edita

    2009-01-01

    The subject of this thesis is a theoretical introduction to audit of the financial statements. The main part is the audit process, particularly the implementation of procedures to assess the adoption of a new contract, the design's overall performance audit, risk assessment, conducting a further audit procedures, analyzing the information obtained, and finally preparing the auditor's report. The last chapter is devoted to the audit program for fixed assets.

  10. Motivace pracovníků v malém podniku

    OpenAIRE

    Charvátová, Soňa

    2010-01-01

    This thesis is concerned with motivation and satisfaction of employees of one company in Prague. The theory is mainly focused on the explanation of motivation and stimulation, labour motivation and employee benefits. The point of the practical part is an analysis of the motivation system and employee satisfaction in the company. The resulting information is explicated. For the parts with the worst findings, some recommendations for improving the present motivation system are suggested.

  11. Esperanzas zozobradas. Apuntes de la primera mitad del siglo xx: El siglo empieza mal

    Directory of Open Access Journals (Sweden)

    Gert Hoffmann

    2009-12-01

    Full Text Available En el presente artículo se relata la historia de vida de un excombatiente austriaco de la Guerra Civil española por el bando republicano hasta su retirada del frente tras la batalla del Ebro. Se expondrán las circunstancias de su nacimiento, concienciación política y participación en el conflicto que asoló España durante tres años. En primer lugar, se destacará la importancia de la I Guerra Mundial para la comprensión de la vida en Austria hasta el Anschluss y en concreto el frente italiano como punto de inflexión tanto para la balanza de la victoria como de la definitiva derrota del imperio austro-húngaro. En segundo lugar, se relatarán las tensiones y hechos de violencia social vividos en Austria en los días previos al Anschluss, la militancia política del autor y su decisión de ingresar en las Brigadas Internacionales para venir a combatir a España. Finalmente, se describirá el proceso de reclutamiento y viaje a la Península Ibérica para terminar la narración de su participación en la contienda con la batalla del Ebro y su posterior salida tras la orden gubernamental del 23 de septiembre de 1938.___________________ABSTRACT:This article deals with the history of life of an Austrian ex-combatant of the Spanish Civil War by the republican side, until his retire after the Battle of the Ebro. Circumstances of his birth, political awareness and participation in the Spanish Civil War, that will knock down Spain during three years, are here shown. Firstly, it will be explained the importance of the I World War for the understanding of the life in Austria until the Anschluss, and the meaning of the Italian front as a turning point for the victory or the defeat of the Austro-Hungarian Empire. Secondly, tensions and episodes of social violence occurred in Austria in the first days of the Anschluss, will be described: the author's political militancy and his decision of joining the International Brigades for fighting in Spain, are also pointed up. Finally, the recruitment process and his voyage to Spain are described and his narration ends with his participation in the Battle of the Ebro and his consequent quit after the September 23, 1938 governmental order.

  12. Do mal-estar da existência ao biologismo das relações

    OpenAIRE

    Cristiane Holanda Queiroz; Clara Virginia de Queiroz Pinheiro

    2006-01-01

    With the increasing diffusion of the scientific-technological discourse in the social ambit, searching to exceed the limits of the human experience through the manipulation of life in its biological reality, we can observe the constitution of new ways of conceiving our notion of humanity. Such conception, that has been forged in the last decades, is a contraposition to psychoanalysis from two aspects defined here, which are the dissemination of the theory developed by Sig...

  13. Incidência de TB diagnosticada no pronto-atendimento de um hospital escola na região sudeste do Brasil Incidence of TB diagnosed in the emergency room of a teaching hospital in southeastern Brazil

    Directory of Open Access Journals (Sweden)

    Silvana Spíndola de Miranda

    2009-02-01

    Full Text Available Neste trabalho, analisamos o número de casos de TB em um pronto-atendimento (PA e o perfil de sensibilidade das cepas de Mycobacterium tuberculosis. Pacientes atendidos no Hospital das Clínicas, em Belo Horizonte (MG, foram selecionados. Entre 2002 e 2005, 240 pacientes com TB foram identificados. Destes, 117 (48,7% foram diagnosticados no PA, 72 (61,5% com baciloscopia positiva. Testes de sensibilidade foram realizados em 90 cepas, sendo 80 (89% sensíveis, 9 (10% resistentes e 1 (1% multirresistente. A incidência de baciloscopia positiva e de TB resistente foi elevada, o que demanda uma adoção urgente de medidas de controle de TB no PA.In this study, we analyzed the number of TB cases in an emergency room (ER and the susceptibility profile of Mycobacterium tuberculosis strains. Patients were selected from among those treated at the Hospital das Clínicas, in the city of Belo Horizonte, Brazil. Between 2002 and 2005, 240 TB patients were identified. Of those, 117 patients (48.7% were diagnosed in the ER, 72 (61.5% presenting positive sputum smear microscopy. Drug susceptibility testing was carried out in 90 strains, of which 80 (89% were sensitive, 9 (10% were resistant, and 1 (1% was multidrug resistant. The incidence of positive smear sputum microscopy and resistant TB strains was high, which calls for the immediate adoption of TB control measures in the ER.

  14. Doenças de aves selvagens diagnosticadas na Universidade Federal do Paraná (2003-2007 Diseases of wild birds diagnosed at the Federal University of Paraná, Brazil (2003-2007

    Directory of Open Access Journals (Sweden)

    Gizah G.C. Santos

    2008-11-01

    Full Text Available Dentre os 253 atendimentos realizados em aves selvagens entre agosto de 2003 a agosto de 2006 no Ambulatório de Animais Selvagens do Hospital Veterinário da Universidade Federal do Paraná, 45 casos (17,8% referiram-se a consultas à espécie Serinus canarius (canário-belga. Dentre as aves atendidas e suas respectivas ordens obteve-se uma maior ocorrência da ordem Psittaciforme. As enfermidades mais freqüentemente visualizadas foram as afecções traumáticas com 56 casos (22,13%. Destas, 17 animais (30,91% possuíam algum tipo de fratura, sendo a fratura rádio-ulnar a mais comum, com 17,65% de ocorrência. As outras moléstias mais relatadas foram a presença de ectoparasitos (12,50% e endoparasitos (10,68%, doenças respiratórias (10,42%, procedimentos preventivos (7,55%, afecções dermatológicas (6,51%, neoplasias (4,95%, afecções oftálmicas (4,43%, afecções gastrintestinais (3,91%, caquexia (3,39%, afecções neurológicas (2,86%, automutilação (2,86%, obesidade (2,34%, agressão por outros animais (1,56 %, doenças nutricionais (1,30%, retenção de ovo (1,04%, bouba aviária (0,78% e gota úrica (0,52%. Tendo em vista a alta prevalência de traumatismos e presença de ecto e endo parasitas que poderiam ser evitados se estivesse ocorrendo um manejo adequado com a ave, sugere-se a necessidade que o Médico Veterinário assuma um papel mais efetivo na Medicina Veterinária Preventiva buscando informar e debater questões referentes ao modo correto de alimentação, criação e manejo das aves, assim como também o esclarecimento acerca das questões referentes às zoonoses quando da consulta veterinária.From 253 wild birds attended at the Wild Animal Ambulatory of the Veterinary Hospital, Paraná Federal University, between August 2003 and August 2006, 45 cases (17.8% were related to the species Serinus canarius (Belgian Canary. Within these attended birds and its respective orders, most morbid conditions occurred with the Psittaciforme order and were caused by traumatism, in 45 cases (14.32%. Of these, 17 animals (30.91% had bone fractures; the most common were on radius-ulna (17.65%. Other conditions were presence of ectoparasites (12.50% and endoparasites (10.68%, respiratory disease (10.42%, dermatological ailments (6.51%, neoplasms (4.95%, ophthalmic illnesses (4.43%, gastrointestinal diseases (3.91%, cachexia (3.39%, neurological diseases (2.86%, self-mutilation (2.86%, obesity (2.34%, aggression by other animals (1.56%, nutritional deficiencies (1.30%, egg retention (1.04%, avian poxvirus (0.78% and uric gout (0.52%, as well as there was clinical routine measures to be taken (7.55%. Traumas and illnesses were observed as the highest prevalence on the casuistic, which could be prevented by correct husbandry practices.

  15. Endocardite por Coxiella burnetii (febre Q: doença rara ou pouco diagnosticada? Relato de caso Endocarditis due to Coxiella burnetii (Q fever: a rare or underdiagnosed disease? Case report

    Directory of Open Access Journals (Sweden)

    Rinaldo Focaccia Siciliano

    2008-08-01

    Full Text Available A febre Q é uma zoonose de distribuição mundial causada por Coxiella burnetii, sendo raros os registros da doença no Brasil. Estudos soroepidemiológicos mostraram uma freqüência relativamente elevada de anticorpos contra Coxiella burnetii em populações com exposição ocupacional. Em humanos, pode se manifestar clinicamente como doença aguda ou crônica, sendo que a endocardite é a forma crônica mais freqüente da febre Q e de maior morbi-mortalidade. Relatamos um caso grave de endocardite por Coxiella burnetii adquirida no Brasil com desfecho fatal, apesar de antibioticoterapia adequada e tratamento cirúrgico valvar.Q fever is a zoonosis of worldwide distribution that is caused by Coxiella burnetii. However, reports of this disease in Brazil are rare. Seroepidemiological studies have shown relatively high frequencies of antibodies against Coxiella burnetii in populations with occupational exposure. In humans, it can be manifested clinically as acute or chronic disease. Endocarditis is the most frequent chronic form of Q fever and the form with the greatest morbidity and mortality. We report a severe case of endocarditis due to Coxiella burnetii acquired in Brazil that had a fatal outcome, despite specific antibiotic therapy and valve surgery treatment.

  16. Prevalencia de enfermedades crónicas diagnosticadas en población inmigrante y autóctona Prevalence of diagnosed chronic disorders in the inmigrant and native population

    Directory of Open Access Journals (Sweden)

    María D. Esteban-Vasallo

    2009-12-01

    Full Text Available Objetivo: Estimar la prevalencia de problemas de salud crónicos en inmigrantes y compararla con la de la población autóctona, utilizando la historia clínica electrónica (HCE de atención primaria (AP. Métodos: Estudio descriptivo transversal con pacientes de 16 y más años incluidos en el sistema sanitario público de la Comunidad de Madrid. Se estimaron prevalencias ajustadas por edad para cada sexo y nacionalidad (agrupada en regiones a partir de los episodios de atención registrados en la HCE de AP con alguna anotación en 2005 o 2006. Resultados: El 36,8% de la población inmigrante presentaba alguna enfermedad crónica (55,3% de autóctonos tras ajustar por edad, con más frecuencia en mujeres y en población de origen africano y latinoamericano. Las enfermedades más prevalentes en los extranjeros fueron las alergias (tasa cruda: 10,2%, las lumbalgias (9,1%, problemas crónicos de piel (6,8% y trastornos mentales (6,4%. Conclusiones: La prevalencia de enfermedades crónicas es menor en la población extranjera y varía según el sexo y la procedencia.Objective: To estimate the prevalence rates of chronic disorders in immigrants and to compare them with those in the native population, based on electronic clinical records in primary care (ECRPC. Methods: We performed a descriptive cross-sectional study in patients aged 16 and over included in the Madrid Regional Public Health System. Age-adjusted prevalence rates for each sex and region were estimated on the basis of medically examined cases registered in the ECRPC with any new data entry made in 2005 or 2006. Results: After age-adjustment, a total of 36.8% immigrants had some chronic health problem (vs. 55.3% natives. These disorders were more frequent among women and among the population from Africa and Latin America. The highest overall prevalence rates in the foreign population were allergy (10.2% crude rate, low-back pain (9.1%, chronic skin problems (6.8% and mental disorders (6.4%. Conclusions: The prevalence rate of chronic disease is lower in the foreign population and differs according to sex and country of origin.

  17. Doenças de ovinos diagnosticadas no Laboratório de Anatomia Patológica Animal da Universidade Federal de Mato Grosso do Sul (1996-2010

    Directory of Open Access Journals (Sweden)

    Thiago L. Almeida

    2013-01-01

    Full Text Available Nas últimas décadas a pecuária ovina cresceu significativamente no Brasil. Concomitantemente, grupos de pesquisas e laboratórios de diagnósticos realizam estudos retrospectivos com a finalidade de fornecer subsídios técnico-científicos para os médicos veterinários. Desta forma, realizou-se um estudo de prevalência nos arquivos do Laboratório de Anatomia Patológica Animal (LAP da Universidade Federal de Mato Grosso do Sul (UFMS no período de Janeiro de 1996 a Dezembro de 2010. O Laboratório de Bacteriologia da UFMS e o Setor de Patologia Veterinária da Universidade Federal do Rio Grande do Sul forneceram apoio diagnóstico nos casos de mannheimiose pulmonar e scrapie, respectivamente. Os laudos da espécie ovina foram revisados e agrupados em conclusivos e inconclusivos, dos quais foram excluídos os casos experimentais e de outros estados e países. Os casos conclusivos foram classificados de acordo com a etiologia da doença. Os exames da espécie ovina somaram 331 laudos (3,97 % de um total de 8.333 casos diagnosticados no período. Destes, foram excluídos sessenta e quatro (19,3% casos experimentais e materiais oriundos de outros estados ou países. Dos 267 casos remanescentes, 87 (32,6% foram inconclusivos e 180 (67,4% considerados conclusivos, sendo 60 (33,3% doenças infecciosas e parasitárias; 45 (25% intoxicações e toxi-infecções; 41 (22,8% "lesões sem causa definida"; 22 (12,2% doenças metabólicas e nutricionais; 10 (5,6% foram classificadas como "outros distúrbios" e 2 (1,1% neoplasmas. A hemoncose, intoxicação por Brachiaria spp., pleuropneumonias, broncopneumonias, pneumonias fibrinonecrosante ou fibrinossupurativa sem causa definida e a intoxicação por cobre foram as doenças mais prevalentes no período estudado. Dois casos de scrapie foram diagnosticados no período.

  18. Doenças de caprinos diagnosticadas na região Central no Rio Grande do Sul: 114 casos Diseases of goats diagnosed in the Central region of Rio Grande do Sul, Brazil: 114 cases

    Directory of Open Access Journals (Sweden)

    Fábio B. Rosa

    2013-02-01

    Full Text Available Foi realizado um estudo retrospectivo dos arquivos do LPV-UFSM e examinados os laudos de necropsias de caprinos realizadas num período de 48 anos (1964 a 2011. Foram analisados 114 laudos de necropsias de caprinos. Deste total, 95 (83,33% tinham diagnóstico conclusivo e 19 (19,66% tinham diagnóstico inconclusivo. Dos 95 casos conclusivos, as doenças infecciosas e parasitárias foram as mais prevalentes, seguidas em ordem decrescente de prevalência, pelas doenças metabólicas e nutricionais, intoxicações e toxi-infecções e alterações do desenvolvimento. Outras alterações de diferentes naturezas e etiologias que não se enquadravam nos grupos de doenças acima afetaram cerca de 10% dos caprinos examinados. A hemoncose foi a principal causa de morte de caprinos na área de abrangência do LPV-UFSM. Eimeriose e listeriose também foram causas importantes de morte. Dentre as doenças metabólicas e nutricionais, urolitíase, osteoporose, toxemia da prenhez, desnutrição e doença dos músculos brancos foram as mais prevalentes. Principalmente as doenças infecciosas e parasitárias e as metabólicas e nutricionais ocorreram muitas vezes na forma de surtos, acarretando maiores perdas econômicas associadas.A retrospective study of the goat necropsies performed over a period of 48 years (1964 to 2011 at the Laboratório de Patologia Veterinária, Universidade Federal de Santa Maria, Rio Grande do Sul (RS state, Brazil, was performed. A total of 114 reports of goat necropsies were analyzed. Ninety five necropsies (83.33% had a conclusive diagnosis and 19 (19.66% had inconclusive diagnosis. Out of the conclusive cases, infectious and parasitary diseases were the most prevalent, followed, in decreasing order of prevalence, by metabolic and nutritional diseases, poisonings and toxi-infections, and developmental diseases. Other conditions or lesions that did not fit any of the above groups of diseases affected about 10% of the necropsied goats. Hemonchosis was the most prevalent cause of death in this study. Eimeriosis and listeriosis were also important causes of goat deaths. Among the metabolic and nutritional diseases, urolithiasis, osteoporosis, pregnancy toxemia, malnutrition, and white muscle disease were the most prevalent. Mostly the infectious and parasitary diseases and the metabolic and nutritional diseases occurred many times as outbreaks, causing even more important economic losses.

  19. Brucelose em bovinos com bursite cervical diagnosticada em abatedouro sob inspeção federal Brucelosis in cattle with supraspinous bursitis diagnosed in an abattoir under federal inspection

    Directory of Open Access Journals (Sweden)

    Laerte Pereira de Almeida

    2000-04-01

    Full Text Available Estudo epidemiológico tipo caso-controle realizado em Uberlândia, Minas Gerais (MG, Brasil, pesquisou a ocorrência de brucelose em bovinos com bursite cervical, abatidos no período de agosto de 1993 a julho de 1994. O diagnóstico sorológico de brucelose foi realizado mediante a prova de soroaglutinação rápida em placa. Os casos de bursite foram identificados por técnico do Serviço de Inspeção Federal (SIF, com base em características morfológicas, previamente padronizadas. Para a determinação da "Razão de Odds" e do risco atribuível entre bursite e brucelose, utilizaram-se 30 animais com o quadro e, como controle, 90 bovinos sem a patologia. Dos animais com bursite, 13,3% eram brucélicos, contra 5,6% do grupo controle (P=0,115. Dentre aqueles com brucelose e bursite, as bolsas continham fibrina (40,0% e projeções digitiformes (33,3%; apenas nas bursites dos sorologicamente negativos encontraram-se presença de pus, de nódulos e de líquido viscoso. A "Razão de Odds" encontrada entre brucelose e bursite foi da ordem de 2,61, não sendo demonstrado associação entre bursite cervical e sorologia positiva para brucelose (P>0,05. No âmbito da Saúde Pública e ocupacional, sugere-se a atenção de técnicos e profissionais, visando diminuir o risco de infecção e evitar contaminação de carcaças, equipamentos e instalações.Epidemiological study case-control type carried out in Triângulo abattoir in the city of Uberlândia in the State of Minas Gerais, Brazil, has identified the ocorrence of brucelosis in bovine with supraspinous bursitis, slaughtered from August, 1993 to July, 1994. To diagnose brucelosis "Rapid Agglutination" test was performed on plate with the padronizated antigen count considered positive over 100. The bursas examined were identified by technicians of the Federal Inspection Service based on the presence of ten standardized morphological characteristics. Using the case-control design, 30 animals identified as having supraspinous bursitis were compared with 90 animals randomly selected, without bursitis- but with other characteristics (sex, background, lot, conformation similar to those affected. All animals were, then, tested for brucelosis. Within the animals with bursitis, 13.33% were found to have brucelosis against 5.56% in the control group (P=0.115. The presence of pus, nodules and viscous fluid was found only among animals who tested negative for brucelosis. The odds ratio found between brucelosis and supraspinous bursitis was 2.61 (P>0.05. As a conclusion it’s suggested attention of technicians and profesionals employed in slaughter houses aiming to reduce the risk of human infection, as well as of carcasses, equipment and installations contamination.

  20. Disseminated nocardiosis due to Nocardia farcinica: diagnosis by thyroid abscess culture Nocardiose disseminada por Nocardia farcinica diagnosticada através do cultivo de abscesso da tireóide

    Directory of Open Access Journals (Sweden)

    Cecília Bittencourt Severo

    2005-12-01

    Full Text Available A previously healthy 75-year-old white male dentist presented with a 6-month history of low-back pain treated with chronic steroid therapy had a Nocardia farcinica infection diagnosed by aspirate of thyroid abscess and six blood cultures. Despite the treatment with parenteral combination of trimethoprim/sulfamethoxazole, the patient failed to respond and died after two days of therapy. Autopsy revealed disseminated nocardiosis, involving lungs with pleural purulent exudate in both sides, heart, thyroid, kidneys, brain, bones, and lumbosacral soft tissue with destruction of L2-L4.Paciente previamente hígido, homem de 75 anos, branco, dentista, apresentou história de seis meses de dor lombar, fez uso crônico de corticoterapia e teve diagnóstico de infecção por Nocardia farcinica através do aspirado de abscesso da tireóide e seis hemocultivos positivos. Apesar do tratamento com a combinação de sulfametoxazol/trimetoprim, o paciente não respondeu indo a óbito dois dias após. A necropsia revelou nocardiose disseminada, envolvendo ambos os pulmões, empiema bilateral, coração, tireóide, rins, cérebro, ossos, e tecidos moles lombossacrais, com destruição da L2-L4.