Sample records for benign gynecological diseases

  1. The debate over robotics in benign gynecology. (United States)

    Rardin, Charles R


    The debate over the role of the da Vinci surgical robotic platform in benign gynecology is raging with increasing fervor and, as product liability issues arise, greater financial stakes. Although the best currently available science suggests that, in the hands of experts, robotics offers little in surgical advantage over laparoscopy, at increased expense, the observed decrease in laparotomy for hysterectomy is almost certainly, at least in part, attributable to the availability of the robot. In this author's opinion, the issue is not whether the robot has any role but rather to define the role in an institutional environment that also supports the safe use of vaginal and laparoscopic approaches in an integrated minimally invasive surgery program. Programs engaging robotic surgery should have a clear and self-determined regulatory process and should resist pressures in place that may preferentially support robotics over other forms of minimally invasive surgery.

  2. 子宫内膜异位症与其他妇科良性疾病的相关性研究%Correlation between Endometriosis and Other Benign Gynecological Diseases

    Institute of Scientific and Technical Information of China (English)

    蔡柏岑; 周应芳; 石贺元


    目的:探讨子宫内膜异位症(endometriosis,EM)与其它妇科疾病的相关性,为EM诊治提供依据。方法回顾分析2005年7月~2009年6月北京大学第一临床医学院妇产科的妇科盆腔手术病例资料。对EM与妇科疾病的相关因素进行分析。结果①EM与其它妇科疾病相比,患者年龄较轻、初潮年龄较早、月经周期较短、经期较长、痛经及不孕人数较多、术中出血较多,且多合并子宫腺肌病,差异有统计学意义(P<0.05)。②痛经为EM的独立危险因素。③子宫肌瘤合并 EM者,年龄较轻、初潮年龄较早,痛经、不孕者较多;产次及人流次数较少。④子宫腺肌病合并EM者,年龄较轻、初潮年龄较早、未孕未产者较多。⑤其他子宫、卵巢、输卵管良性疾病合并EM者,痛经人数显著增多。结论①EM最常合并子宫腺肌病;②痛经为子宫内膜异位症的独立危险因素。%Objective: To determine the correlation between endometriosis and other benign gynecological diseases. Methods: A retrospective study of patients who received pelvic surgeries in Obstetric & Gynecology department of Peking University first hospital during Jul. 1,2005 to Jun. 30,2009. Identifying the related factors between endometriosis and other benign gynecological diseases. Results:(1) Compared with other gynecologic diseases,patients with endometriosis are more younger, having earlier age at menarche,shorter menstrual cycle,longer period,more dysmenorrhea,infertility and bleeding. Moreover,patients with endometriosis are more common accompanying with adenomyosis (P<0.05). (2) Multivariate logistic regression demonstrates that dysmenorrhea is the risk factor of endometriosis. (3) Compared with leiomyomas,uterine fibroids with endometriosis are younger and having earlier age at menarche,and more dysmenorrhea and infertility. (4) Compared with adenomyosis, endometriosis with adenomyosis is younger and having earlier

  3. Radiotherapy of benign diseases

    Energy Technology Data Exchange (ETDEWEB)

    Haase, W.


    Still today radiotherapy is of decisive relevance for several benign diseases. The following ones are briefly described in this introductory article: 1. Certain inflammatory and degenerative diseases as furuncles in the face, acute thrombophlebitis, recurrent pseudoriparous abscesses, degenerative skeletal diseases, cervical syndrome and others; 2. rheumatic joint diseases; 3. Bechterew's disease; 4. primary presenile osteoporosis; 5. syringomyelia; 6. endocrine ophthalmopathy; 7. hypertrophic processes of the connective tissue; 8. hemangiomas. A detailed discussion and a profit-risk analysis is provided in the individual chapters of the magazine.

  4. Crohn disease and the gynecologic patient. (United States)

    Sides, Cleve; Trinidad, Mari Charisse; Heitlinger, Leo; Anasti, James


    Although Crohn disease (CD) is considered an inflammatory bowel disease, extraintestinal gynecologic manifestations are varied, frequent, and oftentimes difficult to manage. Its predilection for young and reproductive-age women makes it an important disease process for the gynecologist to understand, as its complications can have long-term repercussions on the developmental, sexual, reproductive, and psychological health of affected women. Patients may present with a variety of vulvovaginal, perineal, perianal, and urologic complaints. Perianal involvement from an intestinal fistula is the most common skin manifestation seen in CD. Other gynecologic manifestations include metastatic CD and rectovaginal and urovaginal fistulas. Recognition and accurate diagnosis of extraintestinal gynecologic manifestations, as well as a good understanding of the gynecologic effects of chronic disease, are necessary for optimal management. The article provides an overview of CD and highlights the gynecologic considerations in caring for women affected by this disease.

  5. MicroRNA and gynecological reproductive diseases. (United States)

    Santamaria, Xavier; Taylor, Hugh


    MicroRNAs (miRNAs) are a class of small non-coding RNAs estimated to regulate the translation of mRNAs in 30% of all genes in animals by inhibiting translation. Aberrant miRNA expression is associated with many human diseases, including gynecological diseases, cancer, inflammatory diseases, and cardiovascular disorders. Abnormal expression of miRNAs has been observed in multiple human reproductive tract diseases including preeclampsia, endometrioid endometrial adenocarcinoma, uterine leiomyomata, ovarian carcinoma, endometriosis, and recurrent pregnancy loss. In the following review, an update of the role of microRNA and gynecological diseases is performed covering, not only impact of microRNA dysregulation in the origin of each disease, but also showing the potential useful diagnostic and therapeutic tool that miRNA may play in these gynecological pathologies.

  6. Laparoscopy for benign disease: robotics. (United States)

    Talamini, Mark A


    Currently available robotic surgical systems appear to be particularly suited for use in benign diseases of the gastrointestinal system. Minimally invasive operations for foregut conditions, such as gastroesophageal reflux disease and achalasia, require excellent visibility and precise tissue dissection. Benign lower gastrointestinal diseases, including inflammatory bowel disease and diverticulitis, also can be approached using robotic assistance. Disadvantages include expense and the loss of tactile feedback. Early clinical results are promising.

  7. Radical pancreaticoduodenectomy for benign disease.

    LENUS (Irish Health Repository)

    Kavanagh, D O


    Whipple\\'s procedure is the treatment of choice for pancreatic and periampullary malignancies. Preoperative histological confirmation of malignancy is frequently unavailable and some patients will subsequently be found to have benign disease. Here, we review our experience with Whipple\\'s procedure for patients ultimately proven to have benign disease. The medical records of all patients who underwent Whipple\\'s procedure during a 15-year period (1987-2002) were reviewed; 112 patients underwent the procedure for suspected malignancy. In eight cases, the final histology was benign (7.1%). One additional patient was known to have benign disease at resection. The mean age was 50 years (range: 30-75). The major presenting features included jaundice (five), pain (two), gastric outlet obstruction (one), and recurrent gastrointestinal haemorrhage (one). Investigations included ultrasound (eight), computerised tomography (eight), endoscopic retrograde cholangiopancreatography (seven; of these, four patients had a stent inserted and three patients had sampling for cytology), and endoscopic ultrasound (two). The pathological diagnosis included benign biliary stricture (two), chronic pancreatitis (two), choledochal cyst (one), inflammatory pseudotumour (one), cystic duodenal wall dysplasia (one), duodenal angiodysplasia (one), and granular cell neoplasm (one). There was no operative mortality. Morbidity included intra-abdominal collection (one), anastomotic leak (one), liver abscess (one), and myocardial infarction (one). All patients remain alive and well at mean follow-up of 41 months. Despite recent advances in diagnostic imaging, 8% of the patients undergoing Whipple\\'s procedure had benign disease. A range of unusual pathological entities can mimic malignancy. Accurate preoperative histological diagnosis may have allowed a less radical operation to be performed. Endoscopic ultrasound-guided fine needle aspirate (EUS-FNA) may reduce the need for Whipple\\'s operation

  8. Cholesterol and benign prostate disease. (United States)

    Freeman, Michael R; Solomon, Keith R


    The origins of benign prostatic diseases, such as benign prostatic hyperplasia (BPH) and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), are poorly understood. Patients suffering from benign prostatic symptoms report a substantially reduced quality of life, and the relationship between benign prostate conditions and prostate cancer is uncertain. Epidemiologic data for BPH and CP/CPPS are limited, however an apparent association between BPH symptoms and cardiovascular disease (CVD) has been consistently reported. The prostate synthesizes and stores large amounts of cholesterol and prostate tissues may be particularly sensitive to perturbations in cholesterol metabolism. Hypercholesterolemia, a major risk factor for CVD, is also a risk factor for BPH. Animal model and clinical trial findings suggest that agents that inhibit cholesterol absorption from the intestine, such as the class of compounds known as polyene macrolides, can reduce prostate gland size and improve lower urinary tract symptoms (LUTS). Observational studies indicate that cholesterol-lowering drugs reduce the risk of aggressive prostate cancer, while prostate cancer cell growth and survival pathways depend in part on cholesterol-sensitive biochemical mechanisms. Here we review the evidence that cholesterol metabolism plays a role in the incidence of benign prostate disease and we highlight possible therapeutic approaches based on this concept.

  9. The burden of health associated with benign gynecological disorders in low-resource settings. (United States)

    Black, Kirsten I; Fraser, Ian S


    Benign gynecological conditions impact on women's lives in a myriad of ways. Many of these conditions exert their burden on women's health because they remain undiagnosed, unacknowledged, or unreported for many years. Some of these conditions cause debilitating primary symptoms, especially of heavy menstrual bleeding, the lethargy of iron deficiency, and of persistent pelvic pain, with substantial impact on quality of life and ability to function on a day-to-day basis. The distressing quality of life impact of pelvic floor prolapse or of local vulval lesions should not be overlooked. Many also have secondary health consequences with adverse effects on fertility and reproductive outcome.

  10. Radioiodine therapy of benign thyroid disease; Radioiodbehandling af benign thyreoideasygdom

    Energy Technology Data Exchange (ETDEWEB)

    Krogh Rasmussen, Aa.; Jarloev, A.E.; Faber, J


    The aim of the study was to evaluate differences in the use of radioactive iodine in the treatment of benigh thyroid disease in Denmark. A questionnaire was distributed to all departments in Denmark which administer radioiodine in the treatment of benign thyroid disease (n=20). Radioiodine is used for patients with toxic nodular goitre and for patients with relapse of toxic diffuse goitre. Four departments did not use radioiodine for volume reduction in non-toxic goitre. Patient information's included very different recommendations regarding cautions in relation to radioiodine treatment. Radioiodine is widely used in the treatment of benign thyroid disease. We recommend a national standardization of the cautions in relation to radioiodine treatment. (au)

  11. Benign paroxysmal positional vertigo in Parkinson's disease

    NARCIS (Netherlands)

    Wensen, E. van; Leeuwen, R.B. van; Zaag-Loonen, H.J. van der; Masius-Olthof, S.; Bloem, B.R.


    BACKGROUND: Dizziness is a frequent complaint of patients with Parkinson's disease (PD), and orthostatic hypotension (OH) is often thought to be the cause. We studied whether benign paroxysmal positional vertigo (BPPV) could also be an explanation. AIM: To assess the prevalence of benign paroxysmal

  12. The decline of hysterectomy for benign disease.

    LENUS (Irish Health Repository)

    Horgan, R P


    Hysterectomy is one of the most common gynaecological surgical procedures performed but there appears to be a decline in the performance of this procedure in Ireland in recent times. We set out to establish the extent of the decline of hysterectomy and to explore possible explanations. Data for hysterectomy for benign disease from Ireland was obtained from the Hospital In-Patient Enquiry Scheme (HIPE) section of the Economic and Social Research Institute for the years 1999 to 2006. The total number of hysterectomies performed for benign disease showed a consistent decline during this time. There was a 36% reduction in the number of abdominal hysterectomy procedures performed.


    Directory of Open Access Journals (Sweden)

    Harish Kumar


    Full Text Available BACKGROUND AND OBJECTIVES: In this modern era of change in dietary habits, life style and increased awareness about the self-breast examination, the rate of detection of breast lump is on increasing trend. Due to its enormous anatomical and physiological changes during different phases of life, breast diseases are not uncommon. The benign conditions however are also associated with morbidity and are of great concern to the patient. This study was carried out to compare the age distribution and proportion of various benign breast tumors, taking into account the various factors associated with them. A correlation of clinical and histopathological diagnosis was drawn and thus the specificity of clinical diagnosis. METHODS: Prospective review of 50 patients from General Surgery department, who are found to have benign breast tumors on clinico-pathological examination, Bowring and Lady Curzon Hospitals, attached to Bangalore Medical College & Research Institute, Bangalore selected during the period from October 2011 to April 2014 on random basis. Post-operative follow up done to note the complications both in hospital and after discharge. RESULTS: Patients predominantly presented with lump in breast were fibroadenoma and fibrocystic disease. Ductal papilloma, phyllodes tumor and lipoma were also encountered. All patients underwent FNAC. Treatment was mostly surgical in the form of excision, simple mastectomy, microdochotomy and wide local excision. All the specimens were subjected to histopathological examination. Using clinical diagnosis, FNAC and histopathology increased the accuracy of diagnosis. Cases followed up and no recurrence was found. CONCLUSIONS: Commonest benign breast tumor found was Fibroadenoma (78%. Majority of the patients were in the active reproductive age group. Fibroadenoma was more common in 2nd decade of life, whereas fibrocystic disease found in 3rd decade. Majority of benign breast lesions presented with painless lump. FNAC

  14. Awareness of Infectious Diseases in Obstetrics and Gynecology Among Residents and Residency Directors

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    Richard H. Beigi


    Full Text Available Awareness of the subspecialty of infectious diseases in obstetrics and gynecology is low among United States residents and residency directors. Objective. Given the burden of infectious diseases on women's health, we sought to assess current awareness, interest, and perceived value of the subspecialty of infectious diseases in obstetrics and gynecology among current United States obstetrics and gynecology residents and residency directors. Methods. Two separate surveys addressing awareness, perceived value and interest in the subspecialty were sent to (1 a random 20% sample of obstetrics and gynecology residents and (2 all obstetrics and gynecology residency directors. Results. Seventy percent of the residency directors were familiar with the subspecialty and 67.0% placed value on infectious disease specialists in an academic department. Thirty percent of the residents reported awareness of the subspecialty. Thirty-six percent of residency directors reported that medical infectious disease specialists deliver formal education to the obstetrics and gynecology residents. Conclusion. United States obstetrics and gynecology residents and residency directors have a low awareness of the subspecialty. An open niche exists for formal education of residents in infectious diseases in obstetrics and gynecology by department specialists. These findings can be incorporated into ongoing recruitment efforts for the subspecialty of infectious diseases in obstetrics and gynecology.

  15. [Endoscopic surgery for benign esophageal diseases]. (United States)

    Ozawa, Soji


    Gastroesophageal reflux disease (GERD) and esophageal achalasia are common benign esophageal diseases. Today minimally invasive surgery is recommended to treat these diseases. Surgical indications for GERD are failure of medical management, medical complications attributable to a large hiatal hernia, 'atypical' symptoms (asthma, hoarseness, cough, chest pain, aspiration), etc. according to the Society of American Gastrointestinal Endoscopic Surgeons (SAGES) guidelines. Laparoscopic Nissen fundoplication has emerged as the most widely accepted procedure for GERD patients with normal esophageal motility. Partial fundoplication (e.g., Toupet fundoplication) is also considered to decrease the possibility of postoperative dysphagia. Although pneumatic dilatation has been the first line treatment for esophageal achalasia, laparoscopic Heller myotomy and partial fundoplication (e.g., Dor fundoplication) to prevent reflux is preferred by most gastroenterologists and surgeons as the primary treatment modality. Laparoscopic surgery for GERD and esophageal achalasia are effective in most patients and safe in all patients. Finally, laparoscopic surgery should be performed only by skilled surgeons.

  16. Laparoendoscopic Single-Site Surgery for the Treatment of Benign Adnexal Disease: A Prospective Trial

    Directory of Open Access Journals (Sweden)

    Anna Fagotti


    Full Text Available Background. To validate feasibility, efficacy, and safeness of laparoscopic treatment of benign adnexal diseases through a single transumbilical access (LESS in a prospective series of patients. Methods. A prospective clinical trial including 30 women has been conducted at the Division of Gynecology of Catholic University of Sacred Hearth of Rome. Patients underwent different laparoscopic procedures by LESS utilizing a multiport trocar and conventional straight laparoscopic instrumentation. Intra and perioperative outcome has been reported. Results. Ten mono/bilateral adnexectomies and 20 cystectomies have been performed by LESS approach. Laparoscopic procedures were completed through a single access in 28 cases (93.4%. No major intra- or postoperative complications were observed. Mean hospital stay was 1.3 days. Conclusions. LESS approach is feasible to treat benign adnexal disease with a very low conversion rate and no early or late complications. More clinical data are needed to confirm these advantages compared to standard laparoscopic technique.

  17. Radioiodine therapy in benign thyroid diseases

    DEFF Research Database (Denmark)

    Bonnema, Steen Joop; Hegedüs, Laszlo


    from (131)I therapy. The individual radiosensitivity, still poorly defined and impossible to quantify, may be a major determinant of the outcome from (131)I therapy. Above all, the impact of (131)I therapy relies on the iodine-concentrating ability of the thyroid gland. The thyroid (131)I uptake (or......Radioiodine ((131)I) therapy of benign thyroid diseases was introduced 70 yr ago, and the patients treated since then are probably numbered in the millions. Fifty to 90% of hyperthyroid patients are cured within 1 yr after (131)I therapy. With longer follow-up, permanent hypothyroidism seems...... of an exact thyroid dose is error-prone due to imprecise measurement of the (131)I biokinetics, and the importance of internal dosimetric factors, such as the thyroid follicle size, is probably underestimated. Besides these obstacles, several potential confounders interfere with the efficacy of (131)I therapy...

  18. [Minimally Invasive Treatment of Esophageal Benign Diseases]. (United States)

    Inoue, Haruhiro


    As a minimally invasive treatment of esophageal achalasia per-oral endoscopic myotomy( POEM) was developed in 2008. More than 1,100 cases of achalasia-related diseases received POEM. Success rate of the procedure was more than 95%(Eckerdt score improvement 3 points and more). No serious( Clavian-Dindo classification III b and more) complication was experienced. These results suggest that POEM becomes a standard minimally invasive treatment for achalasia-related diseases. As an off-shoot of POEM submucosal tumor removal through submucosal tunnel (per-oral endoscopic tumor resection:POET) was developed and safely performed. Best indication of POET is less than 5 cm esophageal leiomyoma. A novel endoscopic treatment of gastroesophageal reflux disease (GERD) was developed. Anti-reflux mucosectomy( ARMS) is nearly circumferential mucosal reduction of gastric cardia mucosa. ARMS is performed in 56 consecutive cases of refractory GERD. No major complications were encountered and excellent clinical results. Best indication of ARMS is a refractory GERD without long sliding hernia. Longest follow-up case is more than 10 years. Minimally invasive treatments for esophageal benign diseases are currently performed by therapeutic endoscopy.

  19. Endo-biliary stents for benign disease: not always benign after all!

    Directory of Open Access Journals (Sweden)

    Jo-Etienne Abela


    Full Text Available This case report describes the presentation, management and treatment of a patient who suffered small bowel perforation due to the migration of his biliary stent which had been inserted for benign disease.

  20. Robotic surgery in gynecology

    Directory of Open Access Journals (Sweden)

    Rooma Sinha


    Full Text Available FDA approved Da Vinci Surgical System in 2005 for gynecological surgery. It has been rapidly adopted and it has already assumed an important position at various centers where this is available. It comprises of three components: A surgeon′s console, a patient-side cart with four robotic arms and a high-definition three-dimensional (3D vision system. In this review we have discussed various robotic-assisted laparoscopic benign gynecological procedures like myomectomy, hysterectomy, endometriosis, tubal anastomosis and sacrocolpopexy. A PubMed search was done and relevant published studies were reviewed. Surgeries that can have future applications are also mentioned. At present most studies do not give significant advantage over conventional laparoscopic surgery in benign gynecological disease. However robotics do give an edge in more complex surgeries. The conversion rate to open surgery is lesser with robotic assistance when compared to laparoscopy. For myomectomy surgery, Endo wrist movement of robotic instrument allows better and precise suturing than conventional straight stick laparoscopy. The robotic platform is a logical step forward to laparoscopy and if cost considerations are addressed may become popular among gynecological surgeons world over.

  1. Compassion in Soranus' Gynecology and Caelius Aurelianus' On Chronic Diseases. (United States)

    Porter, Amber J


    Compassion is considered an important quality for a successful physician today, but did ancient physicians display and value this emotion? How did they feel when faced with the pain and suffering of their patients? How did their patients' emotions affect their own? Many ancient physicians are not well-known for expressions of compassion in their writings; however, this seems to change in the second century AD. One medical writer who exemplifies this change is Soranus of Ephesus (c. 98-138 AD). In his Gynecology, there are a number of passages where compassion is addressed or expressed (such as the chapters on the qualities of the best midwife, the symptom of pica, childbirth, and superstition). The same points can be made of Soranus' On Chronic Diseases, preserved to some extent by the Latin version and adaptation by fifth century AD medical writer Caelius Aurelianus (see, for example, the chapters on chronic headache, mania and elephantiasis). Soranus and Caelius display compassion, understanding, and flexibility of approach when dealing with patient issues; they show themselves willing to change their medical technique when they see that it is doing more harm or discomfort than good. In Soranus and Caelius, we have an image of a physician who acknowledges and is aware of their patients' emotions, beliefs and attitudes, and who exhibits compassion for them.

  2. Sclerotherapy for Benign Cystic Diseases in the Neck

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    Kim, Ji Hoon; Sohn, Chul Ho; Choi, Seung Hong; Yun, Tae Jin [Dept. of Radiology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul (Korea, Republic of)


    Surgery has been the classic treatment of choice for benign cystic diseases, including lymphatic malformation, ranula, branchial cleft cyst, thyroglossal duct cyst, thyroid cyst, parathyroid cyst, and lymphocele. However, surgery is associated with a tendency toward recurrence and may be accompanied by various complications, such as nerve injuries, vascular injuries, and scar formation. Therefore, sclerotherapy using various agents has been applied successfully to treatment of benign cystic diseases in the neck. This editorial reviews the use of various sclerotic agents and application of sclerotherapy to benign cystic diseases in the neck.


    Institute of Scientific and Technical Information of China (English)


    The authors investigated socioeconomic factors associated with prevalent gynecologic diseases in data provided by participants in Women's Health and Health Education Study Program. In 1997, 1515 Zhejiang married rural women aged 15-49 years completed health questionnaires given them by trained medical students who interviewed them at their homes. Single factor and multiple factors analysis were used to determine the relationship between socioeconomic factors and gynecologic morbidity. The data obtained in this study showed that the gynecologic morbidity of the studied married rural women had certain relationship to age, abortion times, postnatal consultation visits and other socioeconomic factors. The finding would be helpful for understanding the current reproductive health of married rural women and preventing gynecologic diseases by controlling the risk factors.

  4. The effect of peritoneal gas drain on postoperative pain in benign gynecologic laparoscopic surgery: a double-blinded randomized controlled trial controlled trial

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    Tharanon C


    Full Text Available Chantip Tharanon, Kovit Khampitak Department of Obstetrics and Gynecology, Srinagarind Hospital, Khon Kaen University, Khon Kaen, Thailand Objectives: To compare the effect of peritoneal gas drain on postoperative pain in benign gynecologic laparoscopic surgery and the amount of postoperative analgesic dosage.Methods: The trial included 45 females who had undergone operations during the period December 2014 to October 2015. The patients were block randomized based on operating time (<2 and ≥2 hours. The intervention group (n=23 was treated with postoperative intraperitoneal gas drain and the control group (n=22 was not. The mean difference in scores for shoulder, epigastric, suprapubic, and overall pain at 6, 24, 48 hours postoperatively were statistically evaluated using mixed-effect restricted maximum likelihood regression. The differences in the analgesic drug usage between the groups were also analyzed using a Student’s t-test. The data were divided and analyzed to two subgroups based on operating time (<2 hours, n=20; and ≥2 hours, n=25.Results: The intervention had significantly lower overall pain than the control group, with a mean difference and 95% confidence interval at 6, 24, and 48 hours of 2.59 (1.49–3.69, 2.23 (1.13–3.34, and 1.48 (0.3–2.58, respectively. Correspondingly, analgesic drug dosage was significantly lower in the intervention group (3.52±1.47 mg vs 5.72±2.43 mg, P<0.001. The three largest mean differences in patients with operating times of ≥2 hours were in overall pain, suprapubic pain at 6 hours, and shoulder pain at 24 hours at 3.27 (1.14–5.39, 3.20 (1.11–5.26, and 3.13 (1.00–5.24, respectively. These were greater than the three largest mean differences in the group with operating times of <2 hours, which were 2.81 (1.31–4.29, 2.63 (0.51–4.73, and 2.02 (0.68–3.36. The greatest analgesic drug requirement was in the control group with a longer operative time.Conclusion: The use of

  5. Impact of radiation therapy for benign diseases; Role de la radiotherapie dans les affections benignes

    Energy Technology Data Exchange (ETDEWEB)

    Kantor, G. [Institut National de la Sante et de la Recherche Medicale (INSERM), Fondation Bergonie, 33 - Bordeaux (France); Van Houtte, P.; Beauvois, S.; Roelandts, M. [Institut Bordet, Brussels (Belgium)


    Radiation therapy of benign diseases represent a wide panel of indications. Some indications are clearly identified as treatment of arteriovenous malformations (AVM), hyperthyroid ophthalmopathy, postoperative heterotopic bone formations or keloid scars. Some indications are under evaluation as complications induced by neo-vessels of age-related macular degeneration or coronary restenosis after angioplasty. Some indications remain controversial with poor evidence of efficiency as treatment of bursitis, tendinitis or Dupuytren`s disease. Some indications are now obsolete such as warts, or contra-indicated as treatment of infant and children. (authors)

  6. Hailey-Hailey Disease (Benign Chronic Pemphigus) (United States)

    ... for Hailey-Hailey disease since it is a genetic disorder. Treating patients for the symptoms does provide patients with relief and reduces the microbial infections. The first part of treatment is to ...

  7. Role of robotic-assisted surgery in benign esophageal diseases. (United States)

    Saurabh, Shireesh; Unger, Eric; Grossman, Julie; Couto, Francisco; Singh, Namrata; Lind, David Scott; Panait, Lucian; Castellanos, Andres


    Laparoscopic treatment of benign esophageal conditions is technically complex with several inherent limitations. Robotic-assisted surgery provides technical improvement and helps to overcome some of these limitations. We therefore report a single surgeon's experience in management of benign esophageal diseases by robotic-assisted surgery. Over a period of 8 consecutive years, a retrospective chart review was performed of 105 patients who underwent robotic-assisted surgery for benign esophageal diseases by a single surgeon. Demographic data and outcome measures were studied. The robotic-assisted procedures included 85 Nissen fundoplications with and without mesh repair, 12 Heller myotomies and eight para-esophageal hernia repairs. The mean total operating time was lowest for the Nissen group (94 min) and highest for the para-esophageal group (183 min). Operating time decreased from a mean of 105 min in the first 20 cases to 84 min in the last 20 cases for the Nissen group (P = 0.014). The mean length of stay was 1.3, 1.6, 1.5 and 4.8 days for the groups, respectively. Persistent symptoms of dysphagia/reflux/dysphonia requiring further investigation were seen in nine (8 %) of these patients. Two of these patients required repeat Nissen fundoplication in the mesh group. Our complication rate, total operating time and length of stay for robotic-assisted benign esophageal surgery are comparable to those reported in the literature. When performed by an experienced surgeon, robotic-assisted surgery is safe and effective in the management of benign esophageal diseases.

  8. The important roles of steroid sulfatase and sulfotransferases in gynecological diseases

    Directory of Open Access Journals (Sweden)

    Tea eLanisnik Rizner


    Full Text Available Gynecological diseases such as endometriosis, adenomyosis and uterine fibroids, and gynecological cancers including endometrial cancer and ovarian cancer, affect a large proportion of women. These diseases are estrogen dependent, and their progression often depends on local estrogen formation. In peripheral tissues, estrogens can be formed from the inactive precursors dehydroepiandrosterone sulfate and estrone sulfate. Sulfatase and sulfotransferases have pivotal roles in these processes, where sulfatase hydrolyzes estrone sulfate to estrone, and dehydroepiandrosterone sulfate to dehydroepiandrosterone, and sulfotransferases catalyze the reverse reactions. Further activation of estrone to the most potent estrogen, estradiol, is catalyzed by 17-ketosteroid reductases, while estradiol can be formed from dehydroepiandrosterone by the sequential actions of 3-hydroxysteroid dehydrogenase-4-isomerase, aromatase, and 17-ketosteroid reductase. This review introduces the sulfatase and sulfotransferase enzymes, in terms of their structures and reaction mechanisms, and the regulation and different transcripts of their genes, together with the importance of their currently known single nucleotide polymorphisms. Data on expression of sulfatase and sulfotransferases in gynecological diseases are also reviewed. There are often unchanged mRNA and protein levels in diseased tissue, with higher sulfatase activities in cancerous endometrium, ovarian cancer cell lines, and adenomyosis. This can be indicative of a disturbed balance between the sulfatase and sulfotransferases enzymes, defining the potential for sulfatase as a drug target for treatment of gynecological diseases. Finally, clinical trials with sulfatase inhibitors are discussed, where two inhibitors have already concluded phase II trials, although so far with no convincing clinical outcomes for patients with endometrial cancer and endometriosis.

  9. Benign duodenocolic fistula as a complication of peptic ulcer disease. (United States)

    Kamani, Fereshteh; Hessami, Reza; Abrishami, Alireza


    A 44-year-old man with upper abdominal pain, diarrhea and 25 kg weight loss since 3 months ago was admitted. He had a history of dyspepsia and peptic ulcer disease 4 months before admission. Gastroduodenal endoscopy and upper gastrointestinal series with barium study were done. Biopsies and CT-scan ruled out malignancies. Endoscopy and radiology studies revealed a duodenocolic fistula. He underwent right hemicolectomy, fistula en bloc excision, and distal gastrectomy surgery with gastrojejunostomy and ileocolic anastomosis. Radiologic modalities are necessary before surgery. Surgery is the only curative treatment in benign cases and reconstruction method is dependent on patient's situation.

  10. Hepatic steatosis: A benign disease or a silent killer

    Institute of Scientific and Technical Information of China (English)


    Steatosis is a common feature of many liver diseases, namely non-alcoholic steatohepatitis (NASH) and hepatitis C virus (HCV) infection, but the pathogenic mechanisms differ. Insulin resistance (IR), a key feature of metabolic syndrome, is crucial for NASH development, associated with many underlying genetically determined or acquired mitochondrial and metabolic defects and culminates to inflammation and progression to fibrosis. This may have potential implications for new drug therapy. In HCV-related disease, steatosis impacts both fibrosis progression and response to treatment. Steatosis in HCV-related disease relates to both viral factors (HCV genotype 3), and host factors (alcohol consumption, overweight, hyperlipidemia, diabetes). Among others, IR is a recognized factor. Hepatic steatosis is reported to be associated with disturbance in the signaling cascade of interferon and downregulation of its receptors. Thus, hepatic steatosis should not be considered a benign feature, but rather a silent killer.

  11. Breast cancer. Part 1: Awareness and common benign diseases. (United States)

    Harmer, Victoria

    Breast cancer is the most common cancer for women in the United Kingdom and topic on which there is much information. This article discusses the principles behind breast awareness and breast health, detailing common benign breast diseases that cause disproportionate anxiety. The NHS Breast Screening Programme is celebrating 20 years of screening this year, and in all randomized controlled trials of women aged 50 and over, mortality from breast cancer is reduced in those offered screening compared with unscreened controls (although the reduction is not statistically significant in all trials). Once a breast cancer is diagnosed, the different characteristics and stage of the disease can be identified through histopathology and scans. These factors will be discussed later in this article, including illustrating if a cancer is hormone sensitive or HER-2 positive, for example. These factors enable clinicians to recommend a treatment pathway suitable for each individual.


    Directory of Open Access Journals (Sweden)

    Soumen Das


    Full Text Available Benign Breast Disease (BBD, commonest cause of morbidity in females due to breast diseases, still offers therapeutic challenge. Several drug therapies (with Evening Primrose Oil, Danazol etc have been tried, but none made gold standard. Reports on effect of Cox-2 inhibitors are scarce. This randomized control trial aims at determination of effect of Cox- inhibitors (Celecoxib in BBD in comparison to Evening Primrose Oil (EPO . Celecoxib showed better reduction in lump size (in 80% than EPO group (in 50%. Pain reduction was excellent in COX -2 groups as compared to EPO group. Recurrence rate was also lower in Celecoxib group at 10 weeks. Side effects were almost nil in both the groups. Celecoxib is better than EPO in the management of BBD. Short course therapy with COX-2 inhibitors gives good pain relief, greater reduction in lump size, low recurrence with minimum side effects.

  13. Holmium-166 therapy of malignant and benign diseases

    Energy Technology Data Exchange (ETDEWEB)

    Park, C.H. [Ajou Univ. School of Medicine, Suwon (Korea)


    Holmium-166 (Ho-166), one of the lanthanide radionuclides and produced upon neutron irradiation of naturally abundant Ho-165, is an almost ideal radionuclide for therapeutic purposes. The reasons for this are: (1) it is a strong beta emitter (Emax = 1.86 MeV) with maximum range in soft-tissue of 8.4 mm, (2) it has a short physical half-life of 26.9 hours, (3) it emits a gamma photon (81 keV, 5.4%) that can be used for external imaging of post-therapy monitoring purpose. Clinical trials of Ho-166 therapy for various malignancies and benign conditions are under way in Korea, {sup 166}Ho(NO{sub 3}) solution is applied into the balloon following percutaneous transfemoral coronary angioplasty (PTCA) in an attempt to inhibit neointimal hyperplasia incident to ballooning injury. Chitosan obtained by deacetylation of naturally abundant chitin is complexed with Ho-166 by mixing acidic chitosan solution at a room temperature with higher than 99% labelling yield. The Ho-166 complex is stable in vitro and vivo. Another benign condition, rheumatoid joint disease, is treated by local administration of the agent into the knee joint for radionuclide synovectomy. Malignant conditions being treated with Ho-166-CHICO (chitosan complex) include cystic brain tumours, malignant ascites and pleural effusion, hepatocellular carcinomas, recurrent melanoma and recurrent rectal carcinomas. Our clinical experience with Ho-166 or Ho-166-CHICO therapy is presented. (orig.)

  14. Does thyroid stunning exist? A model with benign thyroid disease

    Energy Technology Data Exchange (ETDEWEB)

    Sabri, O.; Zimny, M.; Schreckenberger, M.; Meyer-Oelmann, A.; Reinartz, P.; Buell, U. [Clinic of Nuclear Medicine, Aachen Univ. of Technology (Germany)


    With regard to the treatment of differentiated non-medullary thyroid carcinoma, there is controversy over whether radiation from a diagnostic radioiodine ({sup 131}I) application really does have a suppressive effect on the uptake of subsequent therapeutic {sup 131}I (so-called thyroid stunning). However, inherent difficulties in exact remnant/metastatic tissue volumetry make it difficult to quantify how much diagnostic {sup 131}I is actually absorbed (absorbed energy dose) and hence to decide whether a threshold absorbed dose exists beyond which such stunning would occur. Since in benign thyroid disease the target volume can be readily quantified by ultrasonography, we sought to determine definitely whether stunning of thyroid cells occurs upon a second application of radioiodine 4 days following the first one. We therefore studied 171 consecutive patients with benign thyroid disease (diffuse goitre, Graves' disease, toxic nodular goitre) who received two-step {sup 131}I therapy during a single in-patient stay. For application of both calculated {sup 131}I activities we performed kinetic dosimetry of {sup 131}I uptake, effective half-life and absorbed dose. At the second application, patients showed significant stunning (a 31.7% decrease in {sup 131}I uptake, from 34.7%{+-}15.4% at first application to 23.7%{+-}12.3% at second application, P<0.0005) without a significant difference in effective half-life (4.9{+-}1.3 vs 5.0{+-}1.7 days, P>0.2). ANOVA showed that the extent of stunning was influenced significantly only by the absorbed energy dose at first application (F=13.5, P<0.0005), while first-application {sup 131}I activity, target volume, gender and thyroid function had no influence (all F{<=}0.71, all P>0.4). There was no significant correlation between extent of thyroid stunning and first-application {sup 131}I activity (r=0.07, P>0.3), whereas there was a highly significant correlation between thyroid stunning and first absorbed energy dose (r=0.64, P

  15. The appendix: a spectrum of benign and malignant disease. (United States)

    Lord, Christopher; Broadhurst, Jack; Sleight, Simon; McGee, Shaun; Wills, Mark


    This article discusses the radiological appearances and subsequent management of a diverse spectrum of benign and malignant appendiceal pathologies, including those masquerading as acute appendicitis.

  16. [Prevalence of breast and gynecological diseases in female workers in the administrative office and workshop of an automobile part factory]. (United States)

    Bai, L X; Yang, L; Duan, D P; Xu, X Y; Li, Z; Liu, Y M


    Objective: To investigate the prevalence of breast and gynecological diseases in female workers in the administrative office and workshop of an automobile part factory, and to provide a basis for promoting the health of female workers. Methods: In March 2015, color ultrasound examination of the breast, uterus, and bilateral adnexa was performed for all female workers, and routine gynecological examination, routine leucorrhea examination, and thinprep liquid-based cytology test were performed for married female workers. The detection rates of breast and gynecological diseases in female workers in the administrative office and workshop were analyzed. Results: In the 314 female workers, the overall detection rate of breast and gynecological diseases was 86.31%; the detection rate of abnormal breast ultrasound results was 72.93%, mainly breast hyperplasia; the detection rate of abnormal gynecological ultrasound results was 12.14%, mainly hysteromyoma, pelvic effusion, and uterus-rectum fossa effusion. The overall detection rate of cervicitis or vaginitis in married female workers was 66.86%. The univariate analysis showed that compared with those in the administrative office, the female workers in the workshop had significantly higher detection rates of breast hyperplasia and grade 2 breast lesions on the Breast Imaging-Reporting and Data System (BI-RADS) and significantly lower detection rates of hysteromyoma and grade 3 breast lesions on the BI-RADS (all P factory have high prevalence rates of breast and gynecological diseases. Night shifts for female workers in the workshop should be reduced as much as possible, and female workers, especially those in the administrative office, should be guided to release pressure and take a balanced diet.

  17. Recent advancement of therapeutic endoscopy in theesophageal benign diseases

    Institute of Scientific and Technical Information of China (English)


    Over the past 30 years, the field of endoscopy haswitnessed several advances. With the advent ofendoscopic mucosal resection, removal of large mucosallesions have become possible. Thereafter, endoscopicsubmucosal resection was refined, permitting en blocremoval of large superficial neoplasms. Such techniqueshave facilitated the development of antirefluxmucosectomy, a promising novel treatment for gastroesophagealreflux. The introduction and use of overthe scope clips has allowed for endoscopic closureof defects in the gastrointestinal tract, which weretraditionally treated with surgical intervention. With thedevelopment of per-oral endoscopic myotomy (POEM),the treatment of achalasia and spastic disorders ofthe esophagus have been revolutionized. From thesubmucosal tunnelling technique developed for POEM,Per oral endoscopic tumor resection of subepithelialtumors was made possible. Simultaneously, advancesin biotechnology have expanded esophageal stentingcapabilities with the introduction of fully covered metaland plastic stents, as well as biodegradable stents.Once deemed a primarily diagnostic tool, endoscopy hasquickly transcended to a minimally invasive interventionand therapeutic tool. These techniques are reviewedwith regards to their application to benign disease ofthe esophagus.

  18. Guideline for radioiodine therapy for benign thyroid diseases (version 3)

    Energy Technology Data Exchange (ETDEWEB)

    Dietlein, M.; Schicha, H. [Klinik und Poliklinik fuer Nuklearmedizin der Univ. zu Koeln (Germany); Dressler, J. [Nuklearmedizinische Klinik der Henriettenstiftung, Hannover (Germany); Gruenwald, F. [Klinik und Poliklinik fuer Nuklearmedizin der Univ. Frankfurt (Germany); Leisner, B. [Abt. fuer Nuklearmedizin des Allg. Krankenhauses St. Georg, Hamburg (Germany); Moser, E. [Abt. fuer Nuklearmedizin der Radiologischen Universitaetsklinik Freiburg (Germany); Reiners, C.; Schneider, P. [Klinik und Poliklinik fuer Nuklearmedizin der Univ. Wuerzburg (Germany); Schober, O. [Klinik und Poliklinik fuer Nuklearmedizin der Univ. Muenster (Germany)


    The version 3 of the guideline for radioiodine therapy for benign thyroid diseases presents first of all a revision of the version 2. The chapter indication for radioiodine therapy, surgical treatment or antithyroid drugs bases on an interdisciplinary consensus. The manifold criteria for decision making consider the entity of thyroid disease (autonomy, Graves' disease, goitre, goitre recurrence), the thyroid volume, suspicion of malignancy, cystic nodules, risk of surgery and co-morbidity, history of subtotal thyroidectomy, persistent or recurrent thyrotoxicosis caused by Graves' disease including known risk factors for relapse, compression of the trachea caused by goitre, requirement of direct therapeutic effect as well as the patient's preference. Because often some of these criteria are relevant, the guideline offers the necessary flexibility for individual decisions. Further topics are patients' preparation, counseling, dosage concepts, procedural details, results, side effects and follow-up care. The prophylactic use of glucocorticoids during radioiodine therapy in patients without preexisting ophthalmopathy as well as dosage and duration of glucocorticoid medication in patients with preexisting ophthalmopathy need to be clarified in further studies. The pragmatic recommendations for the combined use of radioiodine and glucocorticoids remained unchanged in the 3{sup rd} version. (orig.) [German] Die Version 3 der Leitlinie zur Radioiodtherapie (RIT) bei benignen Schilddruesenerkrankungen stellt im Wesentlichen eine redaktionelle Ueberarbeitung der Version 2 dar. Im Kapitel Indikation und Empfehlungen fuer eine Radioiodtherapie, eine Operation oder eine thyreostatische Therapie bei gutartigen Schilddruesenerkrankungen basiert die Leitlinie auf einem interdisziplinaer abgestimmten Konzept. Die Entscheidungskriterien sind multifaktoriell und beruecksichtigen die Art der Schilddruesenerkrankung (Autonomie, Morbus Basedow, Struma, Rezidivstruma

  19. Benign breast diseases. Radiology, pathology, risk assessment. 2. ed.

    Energy Technology Data Exchange (ETDEWEB)

    Chinyama, Catherine N. [Princess Elizabeth Hospital, Le Vauquiedor, St. Martin' s Guernsey, Channel Islands (United Kingdom); Brighton and Sussex Medical School, Brighton (United Kingdom)


    Radiological and pathological correlation of the full range of benign breast lesions, with emphasis on screen-detected lesions. Detailed discussion of risk assessment. Revised and updated edition, with a new chapter on gynaecomastia. Ideal aid to the management of patients with benign or indeterminate breast lesions in a multidisciplinary setting. The second edition of this book has been extensively revised and updated. There have been numerous scientific advances in the radiology, pathology and risk assessment of benign breast lesions since the publication of the first edition. The first edition concentrated on screen-detected lesions, which has since been rectified; new symptomatic and screen-detected lesions are discussed in the second edition and include: mastitis and breast abscesses, idiopathic granulomatous mastitis, diabetic mastopathy, phyllodes tumours, gynaecomastia and pseudoangiomatous stromal hyperplasia. The chapters on columnar cell lesions and mucocele-like lesions have been extensively updated. Where applicable, genetic analysis of the benign lesions, which is becoming part of personalised medicine in the field of breast cancer, has been included. The book also presents detailed analyses of the main models, such as the Gail Model, used to assess the subsequent risk of breast cancer in individuals. The current trend in the management of all cancers is preventative. Screening mammography detects early curable cancers as well as indeterminate lesions, the latter of which are invariably pathologically benign. The author has collated important benign lesions and, based on peer-reviewed publications, has documented the relative risk of subsequent cancer to allow the patient and the clinician to implement preventative measures where possible. This book will therefore serve as an essential component of multidisciplinary management of patients with symptomatic and screen-detected benign breast lesions.

  20. Imaging of the thyroid in benign and malignant disease. (United States)

    Intenzo, Charles M; Dam, Hung Q; Manzone, Timothy A; Kim, Sung M


    The thyroid gland was one of the first organs imaged in nuclear medicine, beginning in the 1940s. Thyroid scintigraphy is based on a specific phase or prelude to thyroid hormone synthesis, namely trapping of iodide or iodide analogues (ie, Tc99m pertechnetate), and in the case of radioactive iodine, eventual incorporation into thyroid hormone synthesis within the thyroid follicle. Moreover, thyroid scintigraphy is a reflection of the functional state of the gland, as well as the physiological state of any structure (ie, nodule) within the gland. Scintigraphy, therefore, provides information that anatomical imaging (ie, ultrasound, computed tomography [CT], magnetic resonance imaging) lacks. Thyroid scintigraphy plays an essential role in the management of patients with benign or malignant thyroid disease. In the former, the structure or architecture of the gland is best demonstrated by anatomical or cross-sectional imaging, such as ultrasound, CT, or even magnetic resonance imaging. The role of scintigraphy, however, is to display the functional state of the thyroid gland or that of a clinically palpable nodule within the gland. Such information is most useful in (1) patients with thyrotoxicosis, and (2) those patients whose thyroid nodules would not require tissue sampling if their nodules are hyperfunctioning. In neoplastic thyroid disease, thyroid scintigraphy is often standard of care for postthyroidectomy remnant evaluation and in subsequent thyroid cancer surveillance. Planar radioiodine imaging, in the form of the whole-body scan (WBS) and posttherapy scan (PTS), is a fundamental tool in differentiated thyroid cancer management. Continued controversy remains over the utility of WBS in a variety of patient risk groups and clinical scenarios. Proponents on both sides of the arguments compare WBS with PTS, thyroglobulin, and other imaging modalities with differing results. The paucity of large, randomized, prospective studies results in dependence on consensus

  1. Diagnostic and therapeutic pitfalls in benign vocal fold diseases

    Directory of Open Access Journals (Sweden)

    Bohlender, Jörg


    Full Text Available [english] More than half of patients presenting with hoarseness show benign vocal fold changes. The clinician should be familiar with the anatomy, physiology and functional aspects of voice disorders and also the modern diagnostic and therapeutic possibilities in order to ensure an optimal and patient specific management. This review article focuses on the diagnostic and therapeutic limitations and difficulties of treatment of benign vocal fold tumors, the management and prevention of scarred vocal folds and the issue of unilateral vocal fold paresis.

  2. Robotic surgery in gynecology. (United States)

    Alkatout, Ibrahim; Mettler, Liselotte; Maass, Nicolai; Ackermann, Johannes


    Robotic surgery is the most dynamic development in the sector of minimally invasive operations currently. It should not be viewed as an alternative to laparoscopy, but as the next step in a process of technological evolution. The advancement of robotic surgery, in terms of the introduction of the Da Vinci Xi, permits the variable use of optical devices in all four trocars. Due to the new geometry of the "patient cart," an operation can be performed in all spatial directions without re-docking. Longer instruments and the markedly narrower mechanical elements of the "patient cart" provide greater flexibility as well as access similar to those of traditional laparoscopy. Currently, robotic surgery is used for a variety of indications in the treatment of benign gynecological diseases as well as malignant ones. Interdisciplinary cooperation and cooperation over large geographical distances have been rendered possible by telemedicine, and will ensure comprehensive patient care in the future by highly specialized surgery teams. In addition, the second operation console and the operation simulator constitute a new dimension in advanced surgical training. The disadvantages of robotic surgery remain the high costs of acquisition and maintenance as well as the laborious training of medical personnel before they are confident with using the technology.

  3. Integrative medicine:the guide line in women's reproductive health and the treatment of gynecological disease

    Institute of Scientific and Technical Information of China (English)

    Yu jin


    Integrative medicine follows the principles in TCM that nature and human beings being correspondent with its holistic and dialectic views and explores the integrating point with theories and scientific data in modern medicine. During study on 16 gynecological diseases, the deficiency. In patients with pubertal uterine bleeding, ovulation is induced by acupuncture via decrease in central β-endorphin (β-EP) levels, which leads to the cure of anorexia nervosa by acupuncture via decrease in serum cortisol levels in early 1980s. These results in TCM lead to the idea that neuro-endocrine system is directly related to metabolic system which is also proved to be true in the treatment of polycystic ovary syndrome (PCOS) with or without hyperinsulinemia by two formulas (Yu's Tonifying Ricipe and Tian Gui Recipe,TGR) respectively according to differential diagnosis in TCM. Ovulation resulted with decrease in obesity, acanthosis nigricans, serum androgen, insulin, leptin and hyperthalamic neuropeptide Y (NPY), proopiomalanocortin (POMC) levels based on scientific data from both patients and an animal modal. It suggests that metabolic network, and the incidence of obesity, hypertension, diabetes and cancers of the endometrium and breast may be reduced among patients with PCOS in their future life while these recipes being taken long period. For perimenopausal syndrome, formula Geng Nian Chun (GNC)without increase in serum estrogen levels. In aging rats, it was found that GNC increased the ER and ERmRNA expressions in the ovarian axis and the spleen accompanying with increase in central β-EP, serotonin (5-HT) and peripheral interlutin-2 (IL-2) levels in aging rats without changes of estrogen levels. These data may refer to the release of symptoms in women with postmenopausal syndome. It suggests that GNC up-regulates the fading of neuro-endocrine-immune network. Prevention, alleviation of osteoporosis, cardiovascular disease and Alzheimer disease may be expected in aging

  4. Dosimetry in radioiodine therapy of benign thyroid diseases. Background and practice; Dosimetrie bei Radioiodtherapie benigner Schilddruesenerkrankungen. Hintergrund und Durchfuehrung

    Energy Technology Data Exchange (ETDEWEB)

    Bockisch, A.; Sonnenschein, W.; Jentzen, W.; Hartung, V.; Goerges, R. [Universitaetsklinikum Essen (Germany). Klinik fuer Nuklearmedizin


    Radioiodine therapy of benign thyroid diseases (focal = [toxic adenoma], multifocal, disseminated autonomy, Grave's disease or clinical relevant goitre) needs to be and can be performed individually for each patient. Most frequently a radioiodine test is performed applying a small activity of iodine-131 ({sup 131}I). The paper discusses some protocols for pre- or posttherapeutic dosimetry and discusses their advantages and disadvantages. All are based on the volumetry of the target tissue as well as the radioiodine kinetics in the target volume what may be represented by maximum uptake and half life of iodine retention in the thyroid. Possible disturbances and measuring uncertainties of these parameters are presented and discussed. In spite of the discussed uncertainties in dosimetry, due to its high therapeutic width radioiodine therapy is a very successful procedure to cure hyperthyroidism or to reduce goitre volume with only little side effects. (orig.)

  5. Dietary intakes, resting metabolic rates, and body composition in benign and malignant gastrointestinal disease.


    Burke, M.; Bryson, E I; Kark, A E.


    Dietary protein and energy intakes were assessed in 42 patients with cancer and 24 with benign conditions of the gastrointestinal tract. The relations of dietary intake to body composition was examined. Resulting metabolic rate was measured in 51 patients. No significant differences in dietary intake or metabolic rate were found between patients with cancer and those with benign disease. There were significant positive correlations between protein and energy intakes and the ratio of total bod...

  6. Radiotherapy in benign diseases: Morbus Peyronie; Strahlentherapie benigner Erkrankungen: Morbus Peyronie

    Energy Technology Data Exchange (ETDEWEB)

    Meineke, V.; Cordes, N. [Inst. fuer Radiobiologie der Bundeswehr, Muenchen (Germany); Uebler, C.; Koehn, F.M.; Hofmann, H.; Ring, J.; Vogt, H.J. [Klinik und Poliklinik fuer Dermatologie und Allergologie, Technische Univ. Muenchen (Germany)


    Patients and Methods: The presented data refer to a retrospective univariant examination of 67 patients, which have been treated for IPP with soft X-rays in the Dermatological Clinic of the Technical University of Munich between 1990 and 1995. The aim of the study was to examine, how far a progression of the disease can be stopped with soft X-rays and how the pain symptomatic is reduced. Results: In 58 of 67 examined patients (86.6%) a progression of the disease could be stopped. 25 out of 67 patients (37.3%) complained of pain before therapy. This symptomatic mostly improved totally in 21 patients (84% of the patients with pain). A complete or partial dissolution of the indurations was to be noticed in 41 of 70 indurations (58.6%). In 23 of 60 patients (38.3%) an improvement or totally regression of the deviation was observed. It could be shown that therapeutic outcome significantly correlates to a shorter duration of anamnesis (p < 0.05), smaller plaque size (p < 0.025) and a tendency to lower age of the patients. Conclusion: Radiotherapy of Morbus Peyronie is extremely effective and has a low rate of side effects. (orig.) [German] Patienten und Methoden: Die dargestellten Untersuchungsergebnisse beziehen sich auf die Daten einer univarianten, retrospektiven Untersuchung von 67 Patienten, die in der Dermatologischen Klinik und Poliklinik der Technischen Universitaet Muenchen im Zeitraum von 1990 bis 1995 wegen einer IPP mit Roentgenweichstrahlen behandelt worden sind. Ziel der Untersuchung war es zu ermitteln, inwieweit durch die Roentgenweichstrahlentherapie ein Fortschreiten der Erkrankung verhindert und die Schmerzsymptomatik abgebaut werden konnte. Ergebnisse: Bei 58 von 67 der untersuchten Patienten (86,6%) konnte ein Fortschreiten der Erkrankung gestoppt werden, 25 von 67 Patienten (37,3%) klagten vor der Therapie ueber Schmerzen, zumeist bei der Erektion. Diese Schmerzsymptomatik besserte sich meist vollstaendig bei 21 Patienten (84% der Schmerzpatienten

  7. [Robotic surgery in gynecology]. (United States)

    Csorba, Roland


    Minimally invasive surgery has revolutionized gynecological interventions over the past 30 years. The introduction of the da Vinci robotic surgery in 2005 has resulted in large changes in surgical management. The robotic platform allows less experienced laparoscopic surgeons to perform more complex procedures. It can be utilized mainly in general gynecology and reproductive gynecology. The robot is being increasingly used for procedures such as hysterectomy, myomectomy, adnexal surgery, and tubal anastomosis. In urogynecology, the robot is being utilized for sacrocolopexy as well. In the field of gynecologic oncology, the robot is being increasingly used for hysterectomy and lymphadenectomy in oncologic diseases. Despite the rapid and widespread adaption of robotic surgery in gynecology, there are no randomized trials comparing its efficacy and safety to other traditional surgical approaches. This article presents the development, technical aspects and indications of robotic surgery in gynecology, based on the previously published reviews. Robotic surgery can be highly advantageous with the right amount of training, along with appropriate patient selection. Patients will have less blood loss, less post-operative pain, faster recovery, and fewer complications compared to open surgery and laparoscopy. However, until larger randomized control trials are completed which report long-term outcomes, robotic surgery cannot be stated to have priority over other surgical methods.

  8. Global N-acetylaspartate concentration in benign and non-benign multiple sclerosis patients of long disease duration

    Energy Technology Data Exchange (ETDEWEB)

    Achtnichts, Lutz [Departments of Neurology and Neuroradiology, University Hospital Basel, Petersgraben 4, CH-4031 Basel (Switzerland); Gonen, Oded, E-mail: [Department of Radiology, New York University School of Medicine, 660 First Avenue, 4th Floor, New York, NY 10016 (United States); Rigotti, Daniel J.; Babb, James S. [Department of Radiology, New York University School of Medicine, 660 First Avenue, 4th Floor, New York, NY 10016 (United States); Naegelin, Yvonne [Departments of Neurology and Neuroradiology, University Hospital Basel, Petersgraben 4, CH-4031 Basel (Switzerland); Penner, Iris-Katharina; Bendfeldt, Kerstin [Department of Cognitive Psychology and Methodology, University of Basel, Missionsstrasse 60/62, 4055 Basel (Switzerland); Hirsch, Jochen; Amann, Michael; Kappos, Ludwig [Departments of Neurology and Neuroradiology, University Hospital Basel, Petersgraben 4, CH-4031 Basel (Switzerland); Gass, Achim [Departments of Neurology and Neuroradiology, University Hospital Basel, Petersgraben 4, CH-4031 Basel (Switzerland); Dept. of Neurology, Universitaetsmedizin Mannheim, University of Heidelberg (Germany)


    Background and objective: To examine whether clinically benign multiple sclerosis patients (BMS) show similar losses of their global N-acetylaspartate (NAA) neuronal marker relative to more clinically disabled patients of similar disease duration. Methods: The whole-brain NAA concentration (WBNAA) was acquired with whole-head non-localizing proton MR spectroscopy. Fractional brain parenchymal volume (fBPV), T{sub 2} and T{sub 1} lesion loads, were obtained from the MRI in: (i) 24 BMS patients: 23.1 ± 7.2 years disease duration, median Expanded Disability Status Scale (EDSS) score of 2.0 (range: 0–3); (ii) 26 non-benign MS patients (non-BMS), 24.5 ± 7.4 years disease duration, median EDSS of 4.0 (range: 3.5–6.5); (iii) 15 healthy controls. Results: Controls’ 12.4 ± 2.3 mM WBNAA was significantly higher than the BMS's and non-BMS's 10.5 ± 2.4 and 9.9 ± 2.1 mM (both p < 0.02), but the difference between the patients’ groups was not (p > 0.4). Likewise, the controls’ 81.2 ± 4.5% fBPV exceeded the BMS and non-BMS's 77.0 ± 5.8% and 76.3 ± 8.6% (p < 0.03), which were also not different from one another (p > 0.7). BMS patients’ T{sub 1}-hypointense lesion load, 2.1 ± 2.2 cm{sup 3}, was not significantly different than the non-BMS's 4.1 ± 5.4 cm{sup 3} (p > 0.08) and T{sub 2}-hyperintense loads: 6.0 ± 5.7 cm{sup 3} and 8.7 ± 7.8 cm{sup 3}, were also not different (p > 0.1). Conclusions: WBNAA differentiates normal controls from MS patients but does not distinguish BMS from more disabled MS patients of similar disease duration. Nevertheless, all MS patients who remain RR for 15+ years suffered WBNAA loss similar to the average RR MS population at fourfold shorter disease duration suggesting relative global neuronal sparing or leveling-off of the neurodegeneration rate.

  9. An abnormal screening mammogram causes more anxiety than a palpable lump in benign breast disease

    NARCIS (Netherlands)

    Keyzer-Dekker, C. M. G.; van Esch, L.; de Vries, J.; Ernst, Marloes; Nieuwenhuijzen, G. A. P.; Roukema, J. A.; van der Steeg, A. F. W.


    Being recalled for further diagnostic procedures after an abnormal screening mammogram (ASM) can evoke a high state anxiety with lowered quality of life (QoL). We examined whether these adverse psychological consequences are found in all women with benign breast disease (BBD) or are particular to wo

  10. Urinary β-HCG in Benign and Malignant Urinary Tract Diseases

    Directory of Open Access Journals (Sweden)

    A.-B. Halim


    Full Text Available Detectable leve ls of HCG have been reported in conditions other th an normal pregnancy, including threatened abortion, ectopic pregnancy, trophoblastic tumors, carcinomas of the stomach, liver, pancreas and breast as well as multiple myeloma and melanoma. The present study was conducted to estimate urinary β-HCG in bladder cancer and benign urinary tract disorders. 163 individuals were included, 68 with bladder cancer (60 males and 8 females, 64 with benign urinary tract diseases (55 males and 9 females and 31 normal healthy controls (26 males and 5 females. Urinary β-HCG was estimated by the ELISA technique using the reagents supplied by DRG International Inc., Germany. Results of th e study revealed an overexpression of β-HCG in mali gnant and benign urinary tract diseases. 60.3% of the cancer patients and 29.7% of patients with benign diseases showed urinary β-HCG values above the upper limit of the control group (2mIU/ml .

  11. Helicobacter species are associated with possible increase in risk of biliary lithiasis and benign biliary diseases

    Directory of Open Access Journals (Sweden)

    Pandey Manoj


    Full Text Available Abstract Background Hepato-biliary tract lithiasis is common and present either as pain or as asymptomatic on abdominal ultrasonography for other causes. Although the DNA of Helicobacter species are identified in the gallbladder bile, tissue or stones analyzed from these cases, still a causal relationship could not be established due to different results from different geographical parts. Methods A detailed search of pubmed and pubmedcentral was carried out with key words Helicobacter and gallbladder, gallstones, hepaticolithiasis, cholelithiasis and choledocholithiasis, benign biliary diseases, liver diseases. The data was entered in a data base and meta analysis was carried out. The analysis was carried out using odds ratio and a fixed effect model, 95% confidence intervals for odds ratio was calculated. Chi square test for heterogeneity was employed. The overall effect was calculated using Z test. Results A total of 12 articles were identified. One study used IgG for diagnosis while others used the PCR for Ure A gene, 16 S RNA or Cag A genes. A couple of studies used culture or histopathology besides the PCR. The cumulative results show a higher association of Helicobacter with chronic liver diseases (30.48%, and stone diseases (42.96%(OR 1.77 95% CI 1.2–2.58; Z = 2.94, p = 0.003, the effect of each could not be identified as it was difficult to isolate the effect of helicobacter due to mixing of cases in each study. Conclusion The results of present meta analysis shows that there is a slight higher risk of cholelithiasis and benign liver disease (OR 1.77, however due to inherent inability to isolate the effect of stone disease from that of other benign lesions it is not possible to say for sure that Helicobacter has a casual relationship with benign biliary disease or stone disease or both.

  12. Role of Diagnostic and Therapeutic Endoscopic Ultrasonography in Benign Pancreatic Diseases


    Singla, Vikas; Garg, Pramod Kumar


    Standard imaging of pancreas is generally obtained by computed tomography and magnetic resonance imaging. However endoscopic ultrasound (EUS) has become an indispensable tool for the diagnosis of various pancreatic diseases. Because of the close proximity of the EUS probe to the pancreas, EUS provides excellent images of the pancreas. In this review, we discuss the role of EUS in the clinical management of patients with benign pancreatic diseases, i.e., various forms of pancreatitis.

  13. Levels of PEDF in Pleural Effusions from Lung Adenocarcinoma and Benign Disease Patients

    Directory of Open Access Journals (Sweden)

    Nuria Sánchez-Otero


    Full Text Available Anti-tumor properties assigned to PEDF, beside its role as an inhibitor of angiogenesis, make it a promising candidate in the search of new biomarkers for malignancy. In this study levels of PEDF were investigated in pleural effusions from lung adenocarcinoma and benign inflammatory disease patients. The mean PEDF concentration in the malignant group was slightly superior to that in patients suffering benign diseases (4.59 μg/mL vs 3.97 μg/mL, although the difference did not reach statistical significance (P 0.166. Pleural effusion PEDF levels were not related to gender, age, smoking habit or pleural effusion size. We also investigated the possible relationship of PEDF levels in pleural effusion regarding clinicopathological features. Correlations were found for monocytes (P 0.010 and polymorphonuclear leukocytes (P 0.023 with PEDF levels in pleural effusion of malignant origin.

  14. Total and lipid-bound serum sialic acid in benign and malignant breast disease. (United States)

    Romppanen, J; Eskelinen, M; Tikanoja, S; Mononen, I


    Elevation in the total sialic acid (TSA), TSA/total protein (TSA/TP) and lipid-bound sialic acid (LASA) concentration in serum occurs in breast cancer and we have studied the applicability of the assays in classification of undefined breast tumors. Sialic acid was determined by HPLC and the statistical evaluation included the receiver operating characteristic (ROC) and Youden's index analyses. In cancer patients, the serum LASA and TSA concentration was significantly higher (p breast cancer and benign breast disease and at the specificity level of 0.95 the corresponding sensitivities were 0.32 (TSA), 0.14 (TSA/TP) and 0.23 (LASA). The results indicate that both breast cancer and benign breast disease cause elevation of TSA, TSA/TP and LASA values in serum and do not provide reliable classification of undefined breast tumors.

  15. Ultrasonographic Findings of the Prostatic Disease : Comparative Analysis of the Benign and Malignant Nodules

    Energy Technology Data Exchange (ETDEWEB)

    Song, Yun Gyu; Kim, Ji Yang; Lee, Su Han; Kong, Su Jin; Sung, Young Soon; Kwon, Jae Soo [Masan Samsung General Hospital, Masan (Korea, Republic of)


    We evaluated the characteristics of the benign and malignant nodules on transrectal ultrasound in diagnosis of prostatic disease. Histologic examination of the trans perineal prostatic biopsy of the total 47 cases resulted in 19 cases of BPH, 8 cases of prostatic cancer, and 20 cases of normal prostatic tissue group. The hypoechoic mass in peripheral zone on TRUS had high possibility of prostatic carcinoma and the isoechoic or mixed echogenic mass in central gland had high possibility of benign lesion. Hypoechoic haloes around nodules and cysts were noted in BPH and normal prostatic tissue group, that were compatible with benign lesion. The mean value of PSA was 12.0 ng/ ml in BPH, 8.5 ng / ml in normal prostatic tissue group, and 65.6 ng / ml in prostatic cancer, which was very high in prostatic cancer. Between BPH and normal prostatic tissue group, there was no demonstrable difference in location of nodule, pattern of calcification, and echogenicity of the nodules on TRUS. The size of prostatic gland was relatively smaller and mean value of PSA was lower in normal prostatic tissue group, compared with in BPH. In conclusion, the location of the nodules and PSA value are considered to be important in differentiation of the benign and malignant prostatic nodules

  16. An abnormal screening mammogram causes more anxiety than a palpable lump in benign breast disease


    Keyzer-Dekker, C. M. G.; van Esch, L.; Vries, J.(Nikhef National Institute for Subatomic Physics, Amsterdam, The Netherlands); Ernst, M.F.; Nieuwenhuijzen, G. A. P.; Roukema, J. A.; Steeg, A.F.W. van der


    Being recalled for further diagnostic procedures after an abnormal screening mammogram (ASM) can evoke a high state anxiety with lowered quality of life (QoL). We examined whether these adverse psychological consequences are found in all women with benign breast disease (BBD) or are particular to women referred after ASM. In addition, the influence of the anxiety as a personality characteristic (trait anxiety) was studied. Between September 2002 and February 2010 we performed a prospective lo...

  17. Supracervical versus total hysterectomy in women undergoing hysterectomy for benign gynaecological disease - a new danish recommendation

    DEFF Research Database (Denmark)

    Sloth, Sigurd Beier; Jørgensen, Annemette; Schroll, Jeppe Bennekou

    Background In May 2015 we published a national clinical guideline on hysterectomy for benign gynaecological conditions in cooperation with the Danish Health and Medicines Authority. One of nine investigated areas of interest was whether to perform total or supracervical hysterectomy in women...... undergoing hysterectomy for benign gynaecological disease. Methods A guideline panel of gynaecologists predefined critical and important outcomes for the assessment. The critical outcomes were defined as reoperation, urinary incontinence, sexual function, pelvic organ prolapse and cervical dysplasia...... we looked for existing guidelines in the Guidelines International Network, the National Institute for Health and Care Excellence, the National Guideline Clearinghouse, the Scottish Intercollegiate Guidelines Network, the Health Technology Assessment Database, the Cochrane Library, MEDLINE, EMBASE...

  18. A novel serum microRNA panel to discriminate benign from malignant ovarian disease.

    LENUS (Irish Health Repository)

    Langhe, Ream


    Ovarian cancer is the seventh most common cancer in women and the most frequent cause of gynaecological malignancy-related mortality in women. Currently, no standardized reliable screening test exists. MicroRNA profiling has allowed the identification of signatures associated with diagnosis, prognosis and response to treatment of human tumours. The aim of this study was to determine if a microRNA signature could distinguish between malignant and benign ovarian disease. A training set of 5 serous ovarian carcinomas and 5 benign serous cystadenomas were selected for the initial experiments. The validation set included 20 serous ovarian carcinomas and 20 benign serous cystadenomas. The serum\\/plasma focus microRNA Exiqon panel was used for the training set. For the validation set a pick and mix Exiqon panel, which focuses on microRNAs of interest was used. A panel of 4 microRNAs (let-7i-5p, miR-122, miR-152-5p and miR-25-3p) was significantly down regulated in cancer patients. These microRNAs target WNT signalling, AKT\\/mTOR and TLR-4\\/MyD88, which have previously been found to play a role in ovarian carcinogenesis and chemoresistance. let-7i-5p, miR-122, miR-152-5p and miR-25-3p could act as diagnostic biomarkers in ovarian cancer.

  19. Totally laparoscopic trans-hiatal gastroesophagectomy for benign diseases of the esophago-gastric junction

    Institute of Scientific and Technical Information of China (English)

    Jean-Louis Dulucq; Pascal Wintringer; Ahmad Mahajna


    AIM: To prospectively present our initial experience with totally laparoscopic transhiatal esophagogastrectomies for benign diseases of the cardia and distal esophagus.METHODS: Laparoscopic gastric mobilization and tubularization combined with transhiatal esophageal dissection and intrathoracic esophagogastric anastomosis accomplished by a circular stapler was done in 3 patients. There were 2 females and 1 male patient with a mean age of 73 + 5 years.RESULTS: Two patients were operated on due to benign stromal tumor of the cardia and one patient had severe oesophageal peptic stenosis. Mean blood loss was 47 ± 15 mL and mean operating time was 130 +10 min. There were no cases that required conversion to laparotomy. All patients were extubated immediately after surgery. Soft diet intake and ambulation times were 5.1 ± 0.4 d and 2.6 ± 0.6 d, respectively. There were no intraoperative and postoperative complications and there were no perioperative deaths. The average length of hospital stay was 9.3 + 3 d. All procedures were curative and all resected margins were tumor free. The mean number of retrieved lymph nodes was 18 ± 8.CONCLUSION: Laparoscopic transhiatal esophagogastrectomy for benign lesions has good effects and proves feasible and safe.

  20. Hysterectomy—Current Methods and Alternatives for Benign Indications

    Directory of Open Access Journals (Sweden)

    Michail S. Papadopoulos


    Full Text Available Hysterectomy is the commonest gynecologic operation performed not only for malignant disease but also for many benign conditions such as fibroids, endometrial hyperplasia, adenomyosis, uterine prolapse, dysfunctional uterine bleeding, and cervical intraepithelial neoplasia. There are many approaches to hysterectomy for benign disease: abdominal hysterectomy, vaginal hysterectomy, laparoscopic assisted vaginal hysterectomy (LAVH where a vaginal hysterectomy is assisted by laparoscopic procedures that do not include uterine artery ligation, total laparoscopic hysterectomy (TLH where the laparoscopic procedures include uterine artery ligation, and subtotal laparoscopic hysterectomy (STLH where there is no vaginal component and the uterine body is removed using a morcelator. In the last decades, many new techniques, alternative to hysterectomy with conservation of the uterus have been developed. They use modern technologies and their results are promising and in many cases comparable with hysterectomy. This paper is a review of all the existing hysterectomy techniques and the alternative methods for benign indications.

  1. "Chen Suan gynecological fill solution" of spleen and gynecological diseases from treatment are discussed. Features%《陈素庵妇科补解》从脾胃论治妇产科疾病特色探讨

    Institute of Scientific and Technical Information of China (English)

    陈丽; 尤昭玲


    The "chen suan gynecological fill solution "attaches great importance to the spleen in women with thoughts,the tyre, during dialectical use. Chen elaborated by obstetrical and gynecological diseases with blood disorders, pathogenesis will first, spleen and weak relied heavily TDS spleen transfers, use more did the spleen, tonifying spleen qi benefiting stomach and the kidneys and the spleen, stomach temperature, using gentle drug treatment such method, multi-purpose raise the product, spleen protecting stomach can emulate deconstruction.%非常重视脾胃思想在女性经、带、胎、产中的辨证运用.陈氏阐述妇产科疾病病机必以气血失调、脾胃虚弱为先,辨证论治尤重脾胃调补,多采用行气健脾、补脾健胃、益肾健脾、温中和胃等法治疗,用药平和,多用养脾护胃之品,可供后学效法.

  2. Comparison of Na{sup +}/I{sup -} symporter expression rate in malignant and benign thyroid diseases: immunohistochemical study

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Do Young; Jeong, Young Jin; Lee, Kyung Eun; Park, Heon Soo; Yoo, Young Hyun; Roh, Mee Sook [Donga University College of Medicine, Busan (Korea, Republic of)


    Previous studies have not showed consistent results for the level of expression of sodium/iodide symporter (NIS) in thyroid diseases, especially malignant tumor. We undertook this study to evaluate the distribution of NIS expression in malignant thyroid diseases and compare with that in benign thyoid disease. Total patients were 119 cases (Men 15, 48{+-}13 yrs). Total number of samples were 205 pieces. In malignant thyroid disease, there were 153 samples: 90 in papillary carcinoma, 4 in follicular carcinoma, 2 in medullary carcinoma and 57 in metastatic lymph node. In benign thyroid disease, there were 52 samples: 36 in goiter/cyst, 11 in thyroiditis and 5 in follicular adenoma. Using immunohistochemical methods, we probed 205 samples with monoclonal anti-NIS Ab. Grading of staining was scored as 0 (negative or absent), 1 (weakly positive), 2 (moderately positive) or 3 (strongly positive). Expression rate (ER) of NIS positivity in individual disease entity was expressed as percentage of total number divided by number in 2 plus 3 grade. ERs of malignant thyroid diseases were 63% in papillary carcinoma, 81% in metastatic lymph node, 71% in follicular carcinoma and 100% in medullary carcinoma. ERs of benign thyroid disease were 53% in goiter/cyst, 64% in thyroiditis and 40% in follicular adenoma. ER of benign thyroid deceases was higher than benign thyroid diseases (71% vs 54%). Grading of NIS expression in papillary carcinoma or goiter/cyst was heterogeneously distributed in considerable cases. Normal tissue also showed heterogeneous distribution or NIS expression, which was not correlated with that of primary lesion. In papillary thyroid carcinoma, distribution of NIS expression was heterogeneous and increased, and not different compared with that of benign thyroid disease.

  3. Stenting of the Cystic Duct in Benign Disease: A Definitive Treatment for the Elderly and Unwell

    Energy Technology Data Exchange (ETDEWEB)

    Hersey, N., E-mail: [Sheffield Teaching Hospitals NHS Trust, Department of Radiology, Northern General Hospital (United Kingdom); Goode, S. D., E-mail: [Sheffield Teaching Hospitals NHS Trust, Sheffield Vascular Institute (United Kingdom); Peck, R. J., E-mail:; Lee, F., E-mail: [Sheffield Teaching Hospitals NHS Trust, Department of Radiology, Northern General Hospital (United Kingdom)


    PurposeThere have been few case reports describing cystic duct stent insertion in the management of acute cholecystitis secondary to benign disease with no case series published to date. We present our series demonstrating the role of cystic duct stents in managing benign gallbladder disease in those patients unfit for surgery.Materials and MethodsThirty three patients unfit for surgery in our institution underwent cystic duct stent insertion for the management of acute cholecystitis in the period June 2008 to June 2013. Patients underwent a mixture of transperitoneal and transhepatic gallbladder puncture. The cystic duct was cannulated with a hydrophilic guidewire which was subsequently passed through the common bile duct and into the duodenum. An 8Fr 12-cm double-pigtail stent was placed with the distal end lying within the duodenum and the proximal end within the gallbladder.ResultsTen patients presented with gallbladder perforation, 21 patients with acute cholecystitis, 1 with acute cholangitis and 1 with necrotising pancreatitis. The technical success rate was 91 %. We experienced a 13 % complication rate with 3 % mortality rate at 30 days.ConclusionCystic duct stent insertion can be successfully used to manage acute cholecystitis, gallbladder empyema or gallbladder perforations in those unfit for surgery and should be considered alongside external gallbladder drainage as a definitive mid-term treatment option.

  4. Impact of preventive therapy on the risk of breast cancer among women with benign breast disease. (United States)

    Cuzick, Jack; Sestak, Ivana; Thorat, Mangesh A


    There are three main ways in which women can be identified as being at high risk of breast cancer i) family history of breast and/or ovarian cancer, which includes genetic factors ii) mammographically identified high breast density, and iii) certain types of benign breast disease. The last category is the least common, but in some ways the easiest one for which treatment can be offered, because these women have already entered into the treatment system. The highest risk is seen in women with lobular carcinoma in situ (LCIS), but this is very rare. More common is atypical hyperplasia (AH), which carries a 4-5-fold risk of breast cancer as compared to general population. Even more common is hyperplasia of the usual type and carries a roughly two-fold increased risk. Women with aspirated cysts are also at increased risk of subsequent breast cancer. Tamoxifen has been shown to be particularly effective in preventing subsequent breast cancer in women with AH, with a more than 70% reduction in the P1 trial and a 60% reduction in IBIS-I. The aromatase inhibitors (AIs) also are highly effective for AH and LCIS. There are no published data on the effectiveness of tamoxifen or the AIs for breast cancer prevention in women with hyperplasia of the usual type, or for women with aspirated cysts. Improving diagnostic consistency, breast cancer risk prediction and education of physicians and patients regarding therapeutic prevention in women with benign breast disease may strengthen breast cancer prevention efforts.

  5. Therapeutic consequences of oesophageal function studies in patients with benign oesophageal disease

    DEFF Research Database (Denmark)

    Jakobsen, Erik; Kruse-Andersen, S; Wallin, Lene


    . In all cases where an anatomical diagnosis was replaced by a diagnosis of disordered function, the treatment was in accordance with the findings of the motility studies. None of the patients with oesophageal spasm were suspected of having this disease. It is concluded, that not only anatomical features......Evaluation of oesophageal function was performed in 91 patients referred to a specialized department of cardiothoracic surgery for surgical treatment of benign oesophageal disease. Standard manometry was used in addition to radiology and endoscopy, and in some patients, an acid perfusion test......, an acid clearing test, and a prolonged monitoring of pH in the distal oesophagus were additionally performed. The aim of this study was to evaluate whether assessment of oesophageal function is needed in such a patient group, and whether the results of these investigations were taken into account when...

  6. Couples' adjustment to breast cancer and benign breast disease: a longitudinal analysis. (United States)

    Northouse, L L; Templin, T; Mood, D; Oberst, M


    A comprehensive comparison of couples' adjustment to benign (n = 73 couples) and malignant breast disease (n = 58 couples) at the time of diagnosis and at two follow-up assessments at 60 days and 1 year is reported. Specific objectives were to: (a) compare the concurrent stress, resources, appraisal, and patterns of adjustment of couples in the benign and malignant groups; (b) compare the psychosocial responses of patients versus spouses; and (c) determine the amount of correspondence in levels of adjustment reported by patients and their husbands over time. Multiple instruments with reported reliability and validity were used to measure study variables: Smilkstein Stress Scale, Dyadic Adjustment Scale, Family APGAR, Social Support Questionnaire, Mishel Uncertainty in Illness Scale, Beck Hopelessness Scale, Brief Symptom Inventory, and Psychosocial Adjustment to Illness Scale. Mixed design analyses of covariance (ANCOVA) were used to assess differences between and among couples and examine changes in study variables over time. Significant differences were found in the resources, appraisal, and patterns of adjustment reported by couples in the benign and malignant groups. Couples facing breast cancer reported greater decreases in their marital and family functioning, more uncertain appraisals, and more adjustment problems associated with the illness. In addition, there was a high degree of correspondence between the levels of adjustment reported by women with breast cancer and their husbands over time. Couples who reported high distress or a high number of role problems at diagnosis were likely to remain highly distressed at 60 days and 1 year. Study findings underscore the importance of assisting couples, not just patients, to manage the adjustment difficulties associated with breast cancer.


    Directory of Open Access Journals (Sweden)



    Full Text Available OBJECTIVE To assess safety and feasibility of non-descent vaginal hysterectomy for benign gynaecological disease. METHODS A prospective study was conducted at the Department of Obstetrics and Gynaecology of P K Das Institute of Medical Sciences from January 2013 to December 2013. An effort was made to perform hysterectomies vaginally in women with benign or premalignant conditions in the absence of prolapse. A suspected adnexal pathology, endometriosis, immobility of uterus, uterus size more than 16 weeks was excluded from the study. Vaginal hysterectomy was done in usual manner. In bigger size uterus, morcellation techniques like bisection, debulking, coring, myomectomy, or combination of these were used to remove the uterus. Data regarding age, parity, uterine size, estimated blood loss, length of operation, intraoperative and postoperative complications and hospital stay were recorded. RESULTS A total of 100 cases were selected for non-descent vaginal hysterectomy. Among them, 97 cases successfully underwent nondescent vaginal hysterectomy. Majority of the patients (55% were in age group 40-45 yrs. Four patients were nulligravida and eight patients had previous LSCS. Uterine size was ≤ 12 weeks in 84 cases and > 12-16 weeks in 16 cases. Commonest indication was leiomyoma of uterus (43%. Mean duration of surgery was 70±20.5 minutes. Mean blood loss was 150±65 mL. Reasons for failure to perform NDVH was difficulty in opening pouch of Douglas in two cases because of adhesions and in one case there was difficulty in reaching the fundal myoma which prevented the uterine descent. Intra–operatively, one case had bladder injury (1% that had previous 2 LSCS. Postoperatively, complications were minimal which included postoperative fever (11%, UTI (8% and vaginal cuff infection was (4%. Mean hospital stay was 3.5 days. CONCLUSION Vaginal hysterectomy is safe, feasible in most of the women requiring hysterectomy for benign conditions with less

  8. Thoracic lymphadenopathy in benign diseases: A state of the art review. (United States)

    Nin, Carlos Schüler; de Souza, Vinícius Valério Silveira; do Amaral, Ricardo Holderbaum; Schuhmacher Neto, Roberto; Alves, Giordano Rafael Tronco; Marchiori, Edson; Irion, Klaus Loureiro; Balbinot, Fernanda; Meirelles, Gustavo de Souza Portes; Santana, Pablo; Gomes, Antônio Carlos Portugal; Hochhegger, Bruno


    Lymphadenopathy is a common radiological finding in many thoracic diseases and may be caused by a variety of infectious, inflammatory, and neoplastic conditions. This review aims to describe the patterns of mediastinal and hilar lymphadenopathy found in benign diseases in immunocompetent patients. Computed tomography is the method of choice for the evaluation of lymphadenopathy, as it is able to demonstrate increased size of individual nodes, abnormalities of the interface between the mediastinum and lung, invasion of surrounding fat, coalescence of adjacent nodes, obliteration of the mediastinal fat, and hypo- and hyperdensity in lymph nodes. Intravenous contrast enhancement may be needed to help distinguish nodes from vessels. The most frequent infections resulting in this finding are tuberculosis and fungal disease (particularly histoplasmosis and coccidioidomycosis). Sarcoidosis is a relatively frequent cause of lymphadenopathy in young adults, and can be distinguished from other diseases - especially when enlarged lymph nodes are found to be multiple and symmetrical. Other conditions discussed in this review are silicosis, drug reactions, amyloidosis, heart failure, Castleman's disease, viral infections, and chronic obstructive pulmonary disease.

  9. Topical PDT in the Treatment of Benign Skin Diseases: Principles and New Applications

    Directory of Open Access Journals (Sweden)

    Miri Kim


    Full Text Available Photodynamic therapy (PDT uses a photosensitizer, light energy, and molecular oxygen to cause cell damage. Cells exposed to the photosensitizer are susceptible to destruction upon light absorption because excitation of the photosensitizing agents leads to the production of reactive oxygen species and, subsequently, direct cytotoxicity. Using the intrinsic cellular heme biosynthetic pathway, topical PDT selectively targets abnormal cells, while preserving normal surrounding tissues. This selective cytotoxic effect is the basis for the use of PDT in antitumor treatment. Clinically, PDT is a widely used therapeutic regimen for oncologic skin conditions such as actinic keratosis, squamous cell carcinoma in situ, and basal cell carcinoma. PDT has been shown, under certain circumstances, to stimulate the immune system and produce antibacterial, and/or regenerative effects while protecting cell viability. Thus, it may be useful for treating benign skin conditions. An increasing number of studies support the idea that PDT may be effective for treating acne vulgaris and several other inflammatory/infective skin diseases, including psoriasis, rosacea, viral warts, and aging-related changes. This review provides an overview of the clinical investigations of PDT and discusses each of the essential aspects of the sequence: its mechanism of action, common photosensitizers, light sources, and clinical applications in dermatology. Of the numerous clinical trials of PDT in dermatology, this review focuses on those studies that have reported remarkable therapeutic benefits following topical PDT for benign skin conditions such as acne vulgaris, viral warts, and photorejuvenation without causing severe side effects.

  10. Coloanal anastomosis in the management of benign and malignant rectal disease

    Energy Technology Data Exchange (ETDEWEB)

    Drake, D.B.; Pemberton, J.H.; Beart, R.W. Jr.; Dozois, R.R.; Wolff, B.G.


    The aim was to determine the efficacy, safety, and long-term clinical and functional results of coloanal anastomosis in patients with complicated benign and malignant rectal disease. Twenty-nine patients underwent coloanal or colopouch-anal anastomosis for either carcinoma of the rectum not technically amenable to conventional low anterior resection, severe radiation injury, large benign lower third tumors, or complications of previous operations. The mean age of the patients was 61 years and 82% were men. A diverting colostomy was constructed in 55% of the patients. The mean (+/- SEM) length of follow-up was 20 +/- 3 months. There was no operative mortality. Transient urinary retention, however, occurred in 40%, anastomotic stricture in 28%, and anastomotic leakage in 3.4%. Four patients (14%) could not have intestinal continuity restored and therefore were considered failures. The stool frequency for all remaining patients (N = 25) was 3 +/- 1 per day (mean +/- SEM) and did not vary with age, sex, or indication for operation. Complete continence was achieved by 84% of patients, but no patient was incapacitated by poor bowel function. In patients in whom a conventional colorectostomy is impractical or unwise, coloanal anastomosis is a safe and efficacious alternative operation that preserves anal continence.

  11. Ultrasound guided percutaneous nephrostomy for obstructive uropathy in benign and malignant diseases

    Directory of Open Access Journals (Sweden)

    G. Sood


    Full Text Available OBJECTIVE: Analyze the success rate, complications and overall benefit of ultrasound guided percutaneous nephrostomy (PCN for the relief of obstructive uropathy in benign and malignant diseases. MATERIALS AND METHODS: PCN was performed in 50 kidneys of 32 patients. It was performed in emergency rooms totally under ultrasound guidance by general surgeons. Seldinger technique was used in all cases. Changes in renal function after the procedure were analyzed using paired t-test. RESULTS: The procedure was successfully completed in 42 out of 50 kidneys (84%. There has been no major complication and 28% minor complications. The renal function improved significantly when PCN was performed for benign conditions (mean creatinine 3.52 mg/dL before and 2.18 mg/dL after PCN, however in malignancy there has been no significant improvement in renal function (before PCN mean creatinine 6.39 mg/dL and after PCN 5.41 mg/dL. CONCLUSION: We conclude that PCN can be effectively performed under ultrasound guidance and should be the initial procedure in acutely obstructed kidneys with pyonephrosis and poor renal function. In malignant cases, however, improvement in renal function is possible only if the procedure is carried out at an early stage.

  12. Enfermedades pleurales benignas inducidas por asbesto Benign pleural diseases induced by asbestos

    Directory of Open Access Journals (Sweden)

    J. Boldú


    Full Text Available La exposición al asbesto es una causa importante de patología pleural y se puede producir con intensidades moderadas o ligeras dada la capacidad del asbesto de concentrarse en la pleura. Ello motiva junto a la prolongada latencia existente entre la exposición y la enfermedad, que sigamos viendo durante muchos años manifestaciones clínicas pleurales de exposición previa, a pesar del uso del asbesto cada vez más limitado en las últimas décadas. Dicha exposición puede presentarse con distintas manifestaciones tanto malignas como el mesotelioma como benignas, siendo las principales de éstas el derrame pleural benigno, las placas pleurales, la fibrosis pleural difusa y la atelectasia redonda.Exposure to asbestos is an important cause of pleural pathology and can be produced with light or moderate tendencies given the capacity of asbestos to concentrate in the pleura. Together with the prolonged latency existing between exposure and the disease, this means that for many years we will continue to see pleural clinical manifestations from past exposure, in spite of the increasingly limited use of asbestos in recent decades. This exposure can show itself in different manifestations, both malign, such as mesothelioma, and benign, principally benign pleural effusion, pleural plaques, diffuse pleural fibrosis and massive atelectasis.

  13. Tomographic imaging of the spleen: the role of morphological and metabolic features in differentiating benign from malignant diseases. (United States)

    Mainenti, Pier Paolo; Iodice, Delfina; Cozzolino, Immacolata; Segreto, Sabrina; Capece, Sergio; Sica, Giacomo; Magliulo, Mario; Ciancia, Giuseppe; Pace, Leonardo; Salvatore, Marco


    To evaluate the tomographic features in differentiating benign from malignant splenic diseases, 54 patients with a cytohistological examination and a contrast-enhanced multidetector computed tomography (ce-MDCT) and/or positron emission tomography/computed tomography (PET/CT) were retrospectively selected. Significant associations were observed between ce-MDCT Pattern 3 (focal hyperdense lesion) and Pattern 4 (infarcts/cysts) as well as PET/CT Pattern 3 (focal photopenia/diffuse uptakebenign pathologies, and between ce-MDCT Pattern 1 (splenomegaly without focal lesions) and Pattern 2 (focal hypodense lesion) as well as PET/CT Pattern 1 (diffuse uptake ≥ liver) and Pattern 2 (focal increased uptake) and malignant diseases. No significant association between benign or malignant diseases and spleen volumes and maximum standardized uptake value (SUV(max)) as well as lesion characteristics was observed. The metabolic data do not improve the performance of morphological patterns.

  14. Differential diagnosis of metastatic bone disease and benign bone disease on spine SPECT in patients with low back pain

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Seung Hun; Choi, Yun Young; Cho, Suk Shin [College of Medicine, Hanyang Univ., Seoul (Korea, Republic of)


    One or more abnormal vertebrae detected on bone scintigraphy is a common finding in clinical practice, and it could pose a diagnostic dilemma especially in cancer patients, as either metastasis or benign disease may cause scintigraphic abnormality. The purpose of this study was to determine whether additional spine SPECT has a role in differentiating malignant from benign lesions in patients with back pain. We reviewed spine SPECT studies obtained over a three-year period in 108 patients. Among them, forty-five patients with abnormal SPECT and clinically followed records were evaluated (20 cancer patients were included). Uptake patterns were classified as follows: 1. Body: diffusely increased uptake, linear increased uptake of end plate, segmental increased uptake, and cold defect, 2 Posterior element; posterior to body (pedicle), posterior to intervertebral disc space (facet joint), and spinous process. Lesions were correlated with radiological findings and with final diagnosis. Sixty-nine bone lesions were detected on SPECT images, including 18 metastases, 28 degenerative diseases and 21 compression fractures. Cold defect (6) and segmental increased uptake (5) were dominant findings in metastasis: linear increased uptake (12), and facet joint uptake (15) were in degenerative change; and diffuse increased uptake (9), and linear increased uptake (9) were in compression fracture. Cold defect and segmental increased uptake of body were characteristic findings of metastasis, but care should be taken because compression fracture also shows segmental increased uptake in some cases. Degenerative disease was easily diagnosed because of the typical finding of linear increased uptake of end plate and facet joint. Therefore, additional bone SPECT after planar bone scan would be helpful for differentiating metastasis from benign condition in cancer patients.

  15. Perspectives of radiation therapy in benign diseases; Perspektiven der Strahlentherapie gutartiger Erkrankungen

    Energy Technology Data Exchange (ETDEWEB)

    Schultze, J. [Klinik fuer Strahlentherapie (Radioonkologie), Universitaetsklinikum Schleswig-Holstein (UKSH), Campus Kiel (Germany); Eilf, K. [Praxis fuer Strahlentherapie am UKSH, Campus Kiel (Germany)


    Purpose: the numbers of patients with nonmalignant diseases referred for radiation therapy had to be evaluated for the last 4 years. Patients and methods: in the years 2002, 2004, and 2005 radiation therapy was performed in 61, 40, and 26 patients, respectively. Regularly, more women than men were treated, median age annually was 57, 54, and 55 years, respectively (table 1). The radiotherapy scheme was not modified within the evaluated period. Results: the proportion of nonmalignant diseases among all patients treated decreased from 4.7% in 2002 to 3.3% in 2004 and 2.2% in 2005, respectively. A shift was noticed toward the treatment of four main diseases (endocrine orbitopathy, prevention of heterotopic ossification, meningeoma, tendinitis, table 2). The number of referring physicians decreased from 19 to six. Conclusion: due to administrative restrictions for treatment in hospitals, budget restrictions in private practices and lasting, insufficient revenues for radiotherapy in nonmalignant diseases, radiation therapy for the entire group of benign diseases is endangered. (orig.)

  16. Society of Gynecologic Surgeons (United States)

    ... with mentors and some of the “giants” in gynecology. There is something truly unique about the members ... the O from the G in Obstetrics and Gynecology?”. Our panel discussion will include a dialogue about ...

  17. Incidental Thyroid Carcinoma Diagnosed after Total Thyroidectomy for Benign Thyroid Diseases: Incidence and Association with Thyroid Disease Type and Laboratory Markers

    Directory of Open Access Journals (Sweden)

    D. Askitis


    Full Text Available Objective. Currently, total thyroidectomy (TT is widely used to treat benign thyroid diseases and thyroid carcinoma. The differential diagnosis between benign and malignant thyroid disorders and the potential identification of thyroid microcarcinomas with biochemical markers remain controversial. This retrospective study aimed to estimate the prognostic validity of thyroid autoantibodies, thyroglobulin (Tg, and the thyroid disease type in diagnostic approaches regarding the co-existence of incidental thyroid carcinoma (ITC with benign thyroid diseases. Methods. A cohort of 228 patients was treated with TT for benign thyroid disorders between 2005 and 2010. Thyroid autoantibodies and Tg were preoperatively estimated. Patients were classified according to the preoperative and histologically established diagnoses, and the median values of the biochemical markers were compared between the groups. Results. ITC was detected in 33/228 patients and almost exclusively in the presence of nontoxic thyroid disorders (. There were no statistically significant differences in the median values of the biochemical markers between the benign and malignant groups. There was also no significant association between ITC and chronic lymphocytic thyroiditis. Conclusions. The co-existence of ITC with benign and especially nontoxic thyroid diseases is significant, and treatment of these disorders with TT when indicated can lead to the identification and definitive cure of microcarcinomas. Further studies are required to establish precise markers with prognostic validity for TC diagnosis.

  18. Gynecologic health and disease in relation to the microbiome of the female reproductive tract. (United States)

    Green, Katherine A; Zarek, Shvetha M; Catherino, William H


    It is well established that the vagina is colonized by bacteria that serve important roles in homeostasis. Imbalances in the proportion of bacteria may lead to a predisposition to infection or reproductive complications. Molecular-based approaches demonstrated a greater degree of microbial diversity both within and between women than previously recognized. The vaginal microbiome may fluctuate during various states of health, such as during the menstrual cycle or after menopause, and there may be differences in the vaginal microbiome between women of different ethnicities. Furthermore, the specific composition of the vaginal microbiome may influence the predisposition to dysbiosis and the transmission of sexually transmitted infections. An understanding of the diversity of the vaginal microbial environment during states of health is essential for the identification of risk factors for disease and the development of appropriate treatment.

  19. The Serum Glycome to Discriminate between Early-Stage Epithelial Ovarian Cancer and Benign Ovarian Diseases

    Directory of Open Access Journals (Sweden)

    Karina Biskup


    Full Text Available Epithelial ovarian cancer (EOC is the sixth most common cause of cancer deaths in women because the diagnosis occurs mostly when the disease is in its late-stage. Current diagnostic methods of EOC show only a moderate sensitivity, especially at an early-stage of the disease; hence, novel biomarkers are needed to improve the diagnosis. We recently reported that serum glycome modifications observed in late-stage EOC patients by MALDI-TOF-MS could be combined as a glycan score named GLYCOV that was calculated from the relative areas of the 11 N-glycan structures that were significantly modulated. Here, we evaluated the ability of GLYCOV to recognize early-stage EOC in a cohort of 73 individuals comprised of 20 early-stage primary serous EOC, 20 benign ovarian diseases (BOD, and 33 age-matched healthy controls. GLYCOV was able to recognize stage I EOC whereas CA125 values were statistically significant only for stage II EOC patients. In addition, GLYCOV was more sensitive and specific compared to CA125 in distinguishing early-stage EOC from BOD patients, which is of high relevance to clinicians as it is difficult for them to diagnose malignancy prior to operation.

  20. Perioperative management of benign hepatic tumors in patients with glycogen storage disease type Ia. (United States)

    Oshita, Akihiko; Itamoto, Toshiyuki; Amano, Hironobu; Ohdan, Hideki; Tashiro, Hirotaka; Asahara, Toshimasa


    Glycogen storage disease type Ia (GSD-Ia; von Gierke disease) is an inherited disorder caused by glucose-6-phosphatase deficiency, and there have been some reports of hepatic tumors in patients with this disease. We report two patients with benign hepatic tumors with GSD-Ia. One is a 19-year-old man who underwent segmentectomy 4 for a focal nodular hyperplasia, and the other is a 31-year-old woman who underwent segmentectomies 3, 5, and 6 for hepatic adenomas. Two significant perioperative complications, resulting from the carbohydrate metabolic disorders, hypoglycemia and metabolic acidosis, occurred in both patients. We managed the metabolic complications successfully by administering a sufficient volume of glucose intravenously. Close perioperative monitoring of blood glucose and lactate concentrations is essential in the perioperative management of patients with GSD-Ia. The intravenous administration of glucose, starting with a smaller dose and then increasing the dose, is adequate management for lactic acidosis with or without hypoglycemia during the perioperative period.

  1. Caroli's disease: Description of a case with a benign clinical course. (United States)

    Tzoufi, Meropi; Rogalidou, Maria; Drimtzia, Ecaterini; Sionti, Irini; Nakou, Iliada; Argyropoulou, Maria; Tsianos, Epameinondas V; Siamopoulou-Mavridou, Antigone


    Caroli's disease is a rare congenital disorder characterized by cystic dilatation of the large in-trahepatic bile ducts. The most frequent complications due to biliary stasis are cholelithiasis, cholangitis and sepsis as well as an increased risk of cholangiocarcinoma. Patients may have a history of intermittent abdominal pain, pruritus and/or symptoms of cholangitis. It is rarely diagnosed in childhood. A 12-year-old boy with isolated Caroli's disease is described. This child presented at the age of 2 years, with 4 episodes of recurrent bacterial infections. Interestingly he remained asymptomatic for over 10 years, between the second and third episode. During the 4th episode, when he presented with fever and slight abdominal pain, the diagnosis was made on the basis of radiological findings: U/S, CT, MRI and especially with MRCP, in relation with a more typical picture, resembling cholangitis. Since then he has been followed-up systematically for ten years and remains in good clinical condition without further relapses and with unchanged radiological findings. This atypically benign course of Caroli's disease, with intermittent asymptomatic periods, without any treatment, is very rare.

  2. Caroli’s disease: Description of a case with a benign clinical course (United States)

    Tzoufi, Meropi; Rogalidou, Maria; Drimtzia, Ecaterini; Sionti, Irini; Nakou, Iliada; Argyropoulou, Maria; Tsianos, Epameinondas V.; Siamopoulou-Mavridou, Antigone


    Caroli’s disease is a rare congenital disorder characterized by cystic dilatation of the large in-trahepatic bile ducts. The most frequent complications due to biliary stasis are cholelithiasis, cholangitis and sepsis as well as an increased risk of cholangiocarcinoma. Patients may have a history of intermittent abdominal pain, pruritus and/or symptoms of cholangitis. It is rarely diagnosed in childhood. A 12-year-old boy with isolated Caroli’s disease is described. This child presented at the age of 2 years, with 4 episodes of recurrent bacterial infections. Interestingly he remained asymptomatic for over 10 years, between the second and third episode. During the 4th episode, when he presented with fever and slight abdominal pain, the diagnosis was made on the basis of radiological findings: U/S, CT, MRI and especially with MRCP, in relation with a more typical picture, resembling cholangitis. Since then he has been followed-up systematically for ten years and remains in good clinical condition without further relapses and with unchanged radiological findings. This atypically benign course of Caroli’s disease, with intermittent asymptomatic periods, without any treatment, is very rare. PMID:24713723

  3. Beta-Carotene in Prevention of Cow’s Obstetric- Gynecological Diseases

    Directory of Open Access Journals (Sweden)

    Taisiia DMITRIEVA


    Full Text Available The intensification of the livestock industry is the decisive role of healthy reproduction. The aim of this study was to use "Carofertin" for the preventive purpose of obstetric pathology in high-productive cows (every 10 days and compare with the action of vitamin A. Prophylactic effectiveness of "Carofertin" was defined for prevention of obstetric pathology of high-productive cows whose were predisposed to diseases of parturient (the incidence of retention placenta: 21.7±0.4%, 43.5±0.41%, 65.2±0.38% (P<0.01 and postnatal periods too. The incidence of uterus subinvolution was 13.0±0.34% in the first group, 43.48±0.5% in the second group and 56.5±0.49% in the third group (P<0.001. The incidence of acute puerperal endometritis was 26.0±0.44% in the first group, 34.78±0.49% in the second group and 52.0±0.49% in the third group (P<0.001. We used biochemical and clinical analysis of blood samples to assess the impact of the drug on the functional metabolism and general methods of clinical examination (including rectal and vaginal examination for control over the parturition and puerperal period. It is important to study the problems of obstetric pathology in cows especially during the late stall period and to improve preventive measures.

  4. Transfusion rate and prevalence of unexpected red blood cell alloantibodies in women undergoing hysterectomy for benign disease

    DEFF Research Database (Denmark)

    Thoestesen, Lisbeth M; Rasmussen, Kjeld L; Lauszus, Finn F;


    To determine transfusion rates, risk factors for transfusion and the prevalence of unexpected red blood cell alloantibodies in women undergoing hysterectomy for benign disease. In addition, we aimed to evaluate the necessity of the pretransfusion testing for red blood cell alloantibodies....

  5. Expression of Beta-Human Chorionic Gonadotropin Genes in Renal Cell Cancer and Benign Renal Disease Tissues

    Institute of Scientific and Technical Information of China (English)

    姜永光; 曾甫清; 肖传国; 刘俊敏


    To study the expression of beta-human chorionic gonadotropin (βhCG) genes in renal cellcarcinomas (RCC) and benign renal disease tissues, nested reverse transcription-polymerase chainreaction (RT-PCR) and restriction endonuclease analysis were employed to detect the expression ofβhCG genes in 44 cases of RCC tissues and 24 cases of benign renal disease tissues. It was foundthat 52% RCC samples revealed positive for βhCG mRNA expression. Positive rate in advancedstage and poorly differentiated RCC was higher, but there was no significant difference. The posi-tive rate of βhCG mRNA expression was 54% in 24 cases of benign renal tissues, including 3 casesout of 6 polycystic kidneys, 7 cases out of 13 renal atrophies, 2 cases out of 2 oncocytomas and 1case out of 2 pyonephrotic kidneys. β7 was most frequently transcribed subtype gene independent onthe histology. These findings suggested βhCG gene transcription is not only involved in RCC but al-so in benign renal diseases.

  6. Benign and malignant nodular thyroid disease in acromegaly. Is a routine thyroid ultrasound evaluation advisable?

    Directory of Open Access Journals (Sweden)

    Jordi L Reverter

    Full Text Available Data on the prevalence of benign and malignant nodular thyroid disease in patients with acromegaly is a matter of debate. In the last decade an increasing incidence of thyroid cancer has been reported. The aim of this study was to evaluate the prevalence of goiter, thyroid nodules and thyroid cancer in a large series of patients with acromegaly with a cross-sectional study with a control group. Six Spanish university hospitals participated. One hundred and twenty three patients (50% men; mean age 59±13 years; disease duration 6.7±7.2 years and 50 controls (51% males, mean age 58±15 years were studied. All participants underwent thyroid ultrasound and fine needle aspiration. Cytological analysis was performed in suspicious nodules between 0.5 and 1.0 cm and in all nodules greater than 1.0 cm. Goiter was more frequently found in patients than in controls (24.9 vs. 8.3%, respectively; p<0.001. Nodular thyroid disease as well as nodules greater than 1 cm were also more prevalent in acromegalic patients (64.6%, vs. 28.6%, p<0.05 and 53.3 vs. 28.6%, respectively; p<0.05, and all underwent fine needle aspiration. Suspicious cytology was detected in 4 patients and in none of the controls. After thyroidectomy, papillary thyroid carcinoma was confirmed in two cases (3.3% of patients with thyroid nodules, representing 1.6% of the entire group of patients with acromegaly (2.4% including a case with previously diagnosed papillary thyroid carcinoma. These data indicated that thyroid nodular disease and cancer are increased in acromegaly, thus justifying its routine ultrasound screening.

  7. OCT in Gynecology (United States)

    Kuznetsova, Irina A.; Gladkova, Natalia D.; Gelikonov, Valentin M.; Belinson, Jerome L.; Shakhova, Natalia M.; Feldchtein, Felix I.

    Timely and efficient diagnosis of diseases of the female reproductivesystem is very important from the social viewpoint [1, 2]. Diagnosticefficacy of the existing techniques still needs improvement sincemalignant neoplasms of the female reproductive system organs are stableleaders among causes of death (over 35.9 %) [3]. Each year, 851.9 thousand genital cancer cases are recorded worldwide [1, 2]. However, the diagnostic efficacy of the visual examination with biopsy is limited. Correct interpretation of colposcopic features requires high skills and long-term clinical experience, which makes colposcopy very subjective and limits interobserver agreement [8-10]. OCT is known to visualize in vivo and noninvasively tissue microstructure with spatial resolution approaching the histologic level and therefore can be expected to guide biopsies and to provide real-time tissue structure information when biopsies are contraindicated or impractical. Although thorough clinical studies are required to determine if OCT can be suitable for this purpose in gynecology in general and for cervical cancer in particular, the early results look encouraging. In this chapter, we present a wide spectrum of the OCT studies of different partsof the female reproductive system and demonstrate the potential of the clinical use of this new visualization method in gynecological practice.

  8. 维生素D与妇产科疾病的研究进展%Research progress of vitamin D and gynecological diseases

    Institute of Scientific and Technical Information of China (English)

    陈娜娜; 孔宪超


    传统上认为维生素D主要参与骨代谢和钙磷稳态的调节,与骨质疏松等骨相关的疾病有关.但最近有些研究表明维生素D在妇产科疾病中发挥关键作用,尤其在多囊卵巢综合征(PCOS),子宫内膜异位和卵巢癌,子痫前期和妊娠糖尿病(GDM)中的影响.我们对维生素D与妇产科疾病关系的研究进展进行了综述.%The traditional view that vitamin D is mainly involved in bone metabolism and calcium and phosphorus homeostasis,and bone-related diseases such as osteoporosis related.However,some recent studies have shown that vitamin D plays a key role in obstetrics and gynecology diseases,particularly,endometriosis and ovarian cancer,preeclampsia and gestational diabetes mellitus (GDM) in polycystic ovary syndrome influence (PCOS).Advances in vitamin D article and on the relationship between gynecological and obstetrical diseases were reviewed.

  9. Complex fibroadenoma and breast cancer risk: a Mayo Clinic Benign Breast Disease Cohort Study. (United States)

    Nassar, Aziza; Visscher, Daniel W; Degnim, Amy C; Frank, Ryan D; Vierkant, Robert A; Frost, Marlene; Radisky, Derek C; Vachon, Celine M; Kraft, Ruth A; Hartmann, Lynn C; Ghosh, Karthik


    The purpose of this study is to examine the breast cancer risk overall among women with simple fibroadenoma or complex fibroadenoma and to examine the association of complex fibroadenoma with breast cancer through stratification of other breast cancer risks. The study included women aged 18-85 years from the Mayo Clinic Benign Breast Disease Cohort who underwent excisional breast biopsy from 1967 through 1991. Within this cohort, women who had fibroadenoma were compared to women who did not have fibroadenoma. Breast cancer risk (observed versus expected) across fibroadenoma levels was assessed through standardized incidence ratios (SIRs) by using age- and calendar-stratified incidence rates from the Iowa Surveillance, Epidemiology, and End Results registry. Analyses were performed overall, within subgroups of involution status, with other demographic characteristics (age, year of biopsy, indication for biopsy, and family history), and with histologic characteristics, including overall impression [nonproliferative disease, proliferative disease without atypia (PDWA), or atypical hyperplasia]. Fibroadenoma was identified in 2136 women [noncomplex, 1835 (85.9%); complex, 301 (14.1%)]. SIR for noncomplex fibroadenoma was 1.49 (95% CI 1.26-1.74); for complex fibroadenoma, it was 2.27 (95% CI 1.63-3.10) (test for heterogeneity in SIR, P = .02). However, women with complex fibroadenoma were more likely to have other, concomitant high-risk histologic characteristics (e.g., incomplete involution and PDWA). In analyses stratified by involution status and PDWA, complex fibroadenoma was not an independent risk marker for breast cancer. Complex fibroadenoma does not confer increased breast cancer risk beyond other established histologic characteristics.

  10. High risk for microcarcinoma in thyroid benign diseases. Incidence in a one year period of total thyroidectomies

    Energy Technology Data Exchange (ETDEWEB)

    Carlini, M.; Giovannini, C.; Castaldi, F.; Mercadante, E.; Dell' Avanzato; Zazza, S.; Nania, A. [S. Eugenio Hospital, Rome (Italy). Dept. of General, Abdominal and Thoracic Surgery; Santeusanio, G. [S. Eugenio Hospital, Rome (Italy). Dept. of Pathology; Di Perna, P. [S. Eugenio Hospital, Rome (Italy). Dept. of Endocrinology


    Over the last few years, incidental thyroid microcarcinoma (TMC) has become a frequent disease and its incidence in some reports is considerable. The discovery of new cases depends on the progress of the diagnostics (US scan, fine needle biopsy and cytology, CT, MRI), on the extended indications to thyroidectomy for benign disease and on the attention in pathologic examination of the specimen. The clinical evolution of this disease is not well known: in spite of a high incidence reported in some autoptic series, suggesting that this tumour could have a good prognosis, some authors report an overall incidence of up to 11% of local recurrence, metastasis and mortality. For these reasons the treatment of TMC is still controversial today. Aim of this study was to estimate the incidence and the clinico-pathological findings of TMC over a one year period of total thyroidectomies for diffuse benign thyroid diseases, and to evaluate, on the basis of the frequency of incidental microcarcinoma, if the surgical procedure of complete removal of the gland should be adopted in any case. In this series no patient had pre-operative diagnosis or tentative diagnosis of carcinoma and the incidence of TMC at the final histologic examination was 27.4%. Total thyroidectomy confirmed to be the treatment of choice for diffuse benign diseases and appeared necessary to obtain both, diagnosis and treatment of incidental TMC.

  11. Analysis of Dose Response for Circulatory Disease After Radiotherapy for Benign Disease

    Energy Technology Data Exchange (ETDEWEB)

    Little, Mark P., E-mail: [Radiation Epidemiology Branch, National Cancer Institute, Executive Plaza South, Rockville, Maryland (United States); Kleinerman, Ruth A. [Radiation Epidemiology Branch, National Cancer Institute, Executive Plaza South, Rockville, Maryland (United States); Stovall, Marilyn; Smith, Susan A. [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Mabuchi, Kiyohiko [Radiation Epidemiology Branch, National Cancer Institute, Executive Plaza South, Rockville, Maryland (United States)


    Purpose: To assess the shape of the dose-response for various circulatory disease endpoints, and modifiers by age and time since exposure. Methods and Materials: This was an analysis of the US peptic ulcer data testing for heterogeneity of radiogenic risk by circulatory disease endpoint (ischemic heart, cerebrovascular, other circulatory disease). Results: There were significant excess risks for all circulatory disease, with an excess relative risk Gy{sup -1} of 0.082 (95% CI 0.031-0.140), and ischemic heart disease, with an excess relative risk Gy{sup -1} of 0.102 (95% CI 0.039-0.174) (both p = 0.01), and indications of excess risk for stroke. There were no statistically significant (p > 0.2) differences between risks by endpoint, and few indications of curvature in the dose-response. There were significant (p < 0.001) modifications of relative risk by time since exposure, the magnitude of which did not vary between endpoints (p > 0.2). Risk modifications were similar if analysis was restricted to patients receiving radiation, although the relative risks were slightly larger and the risk of stroke failed to be significant. The slopes of the dose-response were generally consistent with those observed in the Japanese atomic bomb survivors and in occupationally and medically exposed groups. Conclusions: There were excess risks for a variety of circulatory diseases in this dataset, with significant modification of risk by time since exposure. The consistency of the dose-response slopes with those observed in radiotherapeutically treated groups at much higher dose, as well as in lower dose-exposed cohorts such as the Japanese atomic bomb survivors and nuclear workers, implies that there may be little sparing effect of fractionation of dose or low-dose-rate exposure.

  12. Guideline for radioiodine therapy for benign thyroid diseases (version 4); Leitlinie zur Radioiodtherapie (RIT) bei benignen Schilddruesenerkrankungen (Version 4)

    Energy Technology Data Exchange (ETDEWEB)

    Dietlein, M.; Schicha, H. [Koeln Univ. (Germany). Klinik und Poliklinik fuer Nuklearmedizin; Dressler, J. [Nuklearmedizinische Klinik der Henriettenstiftung, Hannover (Germany). Abteilung fuer Nuklearmedizin; Gruenwald, F. [Frankfurt Univ. (Germany). Klinik und Poliklinik fuer Nuklearmedizin; Leisner, B. [Nuklearmedizinische Klinik der Henriettenstiftung des allgemeinen Krankenhauses St. Georg, Hamburg (Germany); Moser, E. [Nuklearmedizinische Klinik der Henriettenstiftung der Radiologischen Universitaetsklinik Freiburg (Germany); Reiners, C.; Schneider, P. [Wuerzburg Univ. (Germany). Klinik und Poliklinik fuer Nuklearmedizin; Schober, O. [Muenster Univ. (Germany). Klinik und Poliklinik fuer Nuklearmedizin


    Version 4 of the guideline for radioiodine therapy for benign thyroid diseases includes an interdisciplinary consensus ondecision making for antithyroid drugs, surgical treatment and radioiodine therapy. The quantitative description of a specific goiter volume for radioiodine therapy or operation was cancelled. For patients with nodular goiter with or without autonomy, manifold circumstances are in favor of surgery (suspicion on malignancy, large cystic nodules, mediastinal goiter, severe compression of the trachea) or in favor of radioiodine therapy (treatment of autonomy, age of patient, co-morbidity, history of prior subtotal thyroidectomy, profession like teacher, speaker or singer). For patients with Graves' disease, radioiodine therapy or surgery are recommended in the constellation of high risk of relapse (first-line therapy), persistence of hyperthyroidism or relapse of hyperthyroidism. After counseling, the patient gives informed consent to the preferred therapy. The period after radioiodine therapy of benign disorders until conception of at least four months was adapted to the European recommendation. (orig.)

  13. Inside Knowledge about Gynecologic Cancer (United States)

    ... 000 women die from a gynecologic cancer. Inside Knowledge: Get the Facts About Gynecologic Cancer Campaign CDC’s Inside Knowledge: Get the Facts About Gynecologic Cancer campaign raises ...

  14. Prognostic factors for late mortality after liver transplantation for benign end-stage liver disease

    Institute of Scientific and Technical Information of China (English)

    ZHANG Ying-cai; LU Min-qiang; YANG Yang; CHEN Gui-hua; ZHANG Qi; LI Hua; ZHANG Jian; WANG Gen-shu; XU Chi; YI Shu-hong; YI Hui-min; CAI Chang-jie


    Background There are increasing numbers of patients who survive more than one year after liver transplantation.Many studies have focused on the early mortality of these patients.However,the factors affecting long-term survival are not fully understood.This study aims to evaluate prognostic factors predicting long-term survival and to explore measures for improving the survival outcomes of patients who underwent liver transplantation for benign end-stage liver diseases.Methods The causes of late death after liver transplantation and potential prognostic factors were retrospectively analyzed for 221 consecutive patients who underwent liver transplantation from October 2003 to June 2008.Twenty-seven variables were assessed using the Kaplan-Meier method,and those variables found to be univariately significant at P <0.10 were entered into a backward step-down Cox proportional hazard regression analysis to identify the independent prognostic factors influencing the recipients' long-term survival.Results Twenty-eight recipients died one year after liver transplantation.The major causes of late mortality were infectious complications,biliary complications,and Hepatitis B virus recurrence/reinfection.After Cox analysis,the five remaining co-variables were:age,ABO blood group,cold ischemia time,post-infection region,and biliary complications.Conclusions The major causes of late mortality were infection,biliary complications and Hepatitis B virus recurrence/reinfection.Five variables (Age,ABO blood group,cold ischemia time,infection,and biliary complications) had significant impacts on patient survival.

  15. An abnormal screening mammogram causes more anxiety than a palpable lump in benign breast disease. (United States)

    Keyzer-Dekker, C M G; van Esch, L; de Vries, J; Ernst, M F; Nieuwenhuijzen, G A P; Roukema, J A; van der Steeg, A F W


    Being recalled for further diagnostic procedures after an abnormal screening mammogram (ASM) can evoke a high state anxiety with lowered quality of life (QoL). We examined whether these adverse psychological consequences are found in all women with benign breast disease (BBD) or are particular to women referred after ASM. In addition, the influence of the anxiety as a personality characteristic (trait anxiety) was studied. Between September 2002 and February 2010 we performed a prospective longitudinal study in six Dutch hospitals. Women referred after ASM or with a palpable lump in the breast (PL), who were subsequently diagnosed with BBD, were included. Before diagnosis (at referral) and during follow-up, questionnaires were completed examining trait anxiety (at referral), state anxiety, depressive symptoms (at referral, one, three and 6 months after diagnosis), and QoL (at referral and 12 months). Women referred after ASM (N=363) were compared with women with PL (N=401). A similar state anxiety score was found in both groups, but a lower psychological QoL score at 12 months was seen in the ASM group. In women with not-high trait anxiety those in the ASM group were more anxious with more depressive symptoms at referral, and reported impaired psychological QoL at referral and at 12 months compared with the PL group. No differences were found between ASM and PL in women with high trait anxiety, but this group scored unfavorably on anxiety, depressive symptoms and QoL compared with women with not-high trait anxiety. ASM evokes more anxiety and depressive symptoms and lowered QoL compared with women referred with PL, especially in women who are not prone to anxiety. Women should be fully informed properly about the risks and benefits of breast cancer screening programs. We recommend identifying women at risk of reduced QoL using a psychometric test.

  16. Evaluation of a potential parathyroid dysfunction under treatment with radioactive iodine of benign thyroid diseases; Pruefung einer potentiellen strahleninduzierten Nebenschilddruesenfunktionsstoerung waehrend einer Radioiodtherapie benigner Schilddruesenerkrankung

    Energy Technology Data Exchange (ETDEWEB)

    Schumacher, Serena Christine


    The intention of the present thesis was the evaluation of a potential parathyroid dysfunction under treatment with radioactive iodine of benign thyroid diseases. It was to be examined whether a change in the parathyroid function would arise within the first week on treatment. So far there are some minor studies existing describing significant changes in the parathyroid hormone serum level within the first months after radioactive iodine therapy of benign and malignant thyroid diseases. Moreover, it is a fact that external beam-radiotherapy can induce neoplasia and that the risk for the subsequent development of primary hyperparathyroidism doubles or triples after external beam-radiotherapy of the head and neck. Up to now, however, an increased incidence for primary hyperparathyroidism following treatment with radioactive iodine ({sup 131}I) could not be proved. At the department of nuclear medicine of the university hospital Giessen-Marburg GmbH, location Marburg, a prospective cohort study was executed on radioactive iodine therapy of benign thyroid diseases with 105 probands (75 women / 30 men, mean age 60.62 ± 14.3 years). According to their thyroid diseases these 105 probands were classified into following subgroups: thyroid adenoma with 23 patients, multifocal thyroid autonomy with 8 patients, disseminated thyroid autonomy with 37 patients as well as the subgroup Graves' hyperthyroidism (without Graves' ophtalmopathy) and accordingly Graves' disease (with Graves' ophtalmopathy) with 37 patients. The serum level of the intact parathyroid hormone was determined directly before starting the radioactive iodine therapy on the admission day and on day 1, 3 and 5 of the radioactive iodine therapy as well as at the ambulant follow-up examination one month after the start of the therapy. In case of 99 of 105 probands the serum level of parathyroid hormone declined on treatment with {sup 131}I with its nadir on day 3 of therapy (decline by 15.71 ng

  17. Evaluation of a potential parathyroid dysfunction under treatment with radioactive iodine of benign thyroid diseases; Pruefung einer potentiellen strahleninduzierten Nebenschilddruesenfunktionsstoerung waehrend einer Radioiodtherapie benigner Schilddruesenerkrankung

    Energy Technology Data Exchange (ETDEWEB)

    Schumacher, Serena Christine


    The intention of the present thesis was the evaluation of a potential parathyroid dysfunction under treatment with radioactive iodine of benign thyroid diseases. It was to be examined whether a change in the parathyroid function would arise within the first week on treatment. So far there are some minor studies existing describing significant changes in the parathyroid hormone serum level within the first months after radioactive iodine therapy of benign and malignant thyroid diseases. Moreover, it is a fact that external beam-radiotherapy can induce neoplasia and that the risk for the subsequent development of primary hyperparathyroidism doubles or triples after external beam-radiotherapy of the head and neck. Up to now, however, an increased incidence for primary hyperparathyroidism following treatment with radioactive iodine ({sup 131}I) could not be proved. At the department of nuclear medicine of the university hospital Giessen-Marburg GmbH, location Marburg, a prospective cohort study was executed on radioactive iodine therapy of benign thyroid diseases with 105 probands (75 women / 30 men, mean age 60.62 ± 14.3 years). According to their thyroid diseases these 105 probands were classified into following subgroups: thyroid adenoma with 23 patients, multifocal thyroid autonomy with 8 patients, disseminated thyroid autonomy with 37 patients as well as the subgroup Graves' hyperthyroidism (without Graves' ophtalmopathy) and accordingly Graves' disease (with Graves' ophtalmopathy) with 37 patients. The serum level of the intact parathyroid hormone was determined directly before starting the radioactive iodine therapy on the admission day and on day 1, 3 and 5 of the radioactive iodine therapy as well as at the ambulant follow-up examination one month after the start of the therapy. In case of 99 of 105 probands the serum level of parathyroid hormone declined on treatment with {sup 131}I with its nadir on day 3 of therapy (decline by 15.71 ng

  18. 红细胞免疫粘附活性、补体受体在良性妇科疾病行腹腔镜手术治疗患者中的变化%Changes of erythrocyte immune adherence activity and CD35 in patients with benign gynecological disorders undergone laparoscopic surgery

    Institute of Scientific and Technical Information of China (English)



    目的:探讨良性妇科疾病患者行腹腔镜手术后红细胞粘附活性以及红细胞补体受体的变化.方法:良性妇科疾病患者64例随机分为研究组和对照组,分别采用腹腔镜治疗和开腹手术治疗.检测两组CD35、RBC-C3bRR、RBC-ICR以及其他免疫指标.结果:两组CD35、RBC-ICR术前及术后、组内及组间比较差异均无统计学意义(P>0.05).RBC-C3bRR两组术后24 h均有下降,但对照组下降更明显,与术前24 h比较,差异有统计学意义(P<0.01),术后72 h两组组间比较,差异有统计学意义(P<0.01).两组术后24h外周血白细胞、IL-6、TNF-α均明显升高(P<0.01),但外周血白细胞、IL-6对照组较研究组升高幅度更大(P<0.01).结论:腹腔镜手术对良性妇科疾病患者红细胞免疫粘附活性、补体受体的影响弱于开腹手术.%Objective:To discuss changes of erythrocyte immune adherence activity and CD35 in patients with benign gynecological disorders undergone laparoscopic surgery.Methods:Sixty-four cases with benign gynecological disorders were devided into study group (34 cases) and control group (30 cases).Erythrocyte immune adherence activity,red blood cell complement receptor,inflammatory cytokines,peripheral white blood cell of the two groups were detected.Results:CD35 and RBC-ICR had no dignificant difference between before and after therapy and two groups (P>0.05).RBC-C3bR decreased apparently after 24h after operation in two groups,and control group decreased more compared to that before surgery(P<0.01).RBC-C3bRR had significant difference between two groups 72h after surgery (P<0.01).Peripheral white blood cell,IL-6 increased apparently 24h after surgery in two groups (P<0.01),and control group increased more (P<0.01).TNF-αincreased apparently 24h after surgery in two groups (P<0.01).Conclusion:Laparoscopic surgery has less impact on erythrocyte immune adherence activity and CD35 in patients with benign gynecological

  19. Breast cancer risk after diagnosis by screening mammography of nonproliferative or proliferative benign breast disease: a study from a population-based screening program. (United States)

    Castells, Xavier; Domingo, Laia; Corominas, Josep María; Torá-Rocamora, Isabel; Quintana, María Jesús; Baré, Marisa; Vidal, Carmen; Natal, Carmen; Sánchez, Mar; Saladié, Francina; Ferrer, Joana; Vernet, Mar; Servitja, Sonia; Rodríguez-Arana, Ana; Roman, Marta; Espinàs, Josep Alfons; Sala, María


    Benign breast disease increases the risk of breast cancer. This association has scarcely been evaluated in the context of breast cancer screening programs although it is a prevalent finding in mammography screening. We assessed the association of distinct categories of benign breast disease and subsequent risk of breast cancer, as well as the influence of a family history of breast cancer. A retrospective cohort study was conducted in 545,171 women aged 50-69 years biennially screened for breast cancer in Spain. The median of follow-up was 6.1 years. The age-adjusted rate ratio (RR) of breast cancer for women with benign breast disease, histologically classified into nonproliferative and proliferative disease with and without atypia, compared with women without benign breast disease was estimated by Poisson regression analysis. A stratified analysis by family history of breast cancer was performed in a subsample. All tests were two-sided. The age-adjusted RR of breast cancer after diagnosis of benign breast disease was 2.51 (95 % CI: 2.14-2.93) compared with women without benign breast disease. The risk was higher in women with proliferative disease with atypia (RR = 4.56, 95 % CI: 2.06-10.07) followed by those with proliferative disease without atypia (RR = 3.58; 95 % CI = 2.61-4.91). Women with nonproliferative disease and without a family history of breast cancer remained also at increased risk of cancer (OR = 2.23, 95 % CI: 1.86-2.68). An increased risk of breast cancer was observed among screening participants with proliferative or nonproliferative benign breast disease, regardless of a family history of breast cancer. This information may be useful to explore risk-based screening strategies.

  20. Clinical Experience of Professor YOU Zhao-ling in Treatment of Gynecological Bleeding Diseases%尤昭玲教授治疗血证临证经验

    Institute of Scientific and Technical Information of China (English)

    李小丹; 曹立幸; 尤昭玲; 袁颂华


    崩漏、经间期出血是妇科临床最常见的血证.湖南中医药大学尤昭玲教授指出,出血期应以止血为首要任务,临床常用四草汤(鹿衔草、马鞭草、旱莲草、仙鹤草各15~20g),随证加减,止血理血,疗效显著.%Abnormal uterine bleeding is a common gynecological disease. Professor YOU Zhao-ling who is a famous TCM gynecologist points out that hemostasis is the most important task when bleeding. And she achieved a significant effect by taking Four Herb Decoction to stop abnormal uterine bleeding and recuperate the blood.

  1. The impact of robotic surgery on gynecologic oncology


    Nick, Alpa M; Ramirez, Pedro T.


    The objective of this article was to review the published scientific literature pertaining to robotic surgery and its applications in gynecologic malignancies and to summarize the impact of robotic surgery on the field of gynecologic oncology. Summarizing data from different gynecologic disease-sites, robotic-assisted surgery is safe, feasible, and demonstrates equivalent histopathologic and oncologic outcomes. In general, benefits to robotic surgery include decreased blood loss, fewer periop...

  2. Gynecologic ultrasonography: recent advances and research in various technical modalities

    Directory of Open Access Journals (Sweden)

    Juraj Drobný


    Full Text Available Juraj DrobnýFirst Department of Obstetrics and Gynaecology, St. Cyril and Method University Hospital, Bratislava, Slovak RepublicAbstract: This paper reviews clinical research in gynecologic sonography, focussing on uterine cavity lesions, endometrial abnormalities and adnexal masses (including endometriosis, and ectopic pregnancy. For each topic, detection of sonographic pathologic features and sonographic mode are discussed, as well as the latest applications of sonodiagnostic methods, and relevant topics in clinical research. A new approach to evaluation of sonographic structures can be seen, including for borderline mucinous and serous ovarian tumors, in mean gray value, evaluation of grade of tissue echogenicity, evaluation of intact endometrial midline echo in ectopic pregnancy, and application of gel instillation sonography. Novel sonographic three-dimensional modalities, such as virtual navigation through three orthogonal planes, multislice tomosonography, volumetry by a virtual organ computer-aided analysis system, three-dimensional power Doppler, and space reconstruction of structures enable gynecologic diagnoses to be made more exactly. Clinical research investigates different sonographic features in benign and malignant gynecologic pathology. For studies of typical signs of benign uterine fibroids, endometrial volume, and vascularization of malignant endometrial tumors, as well as typical benign adnexal structures, the ovarian crescent sign were performed. At this time, no exact sonographic features for distinguishing between benign and malignant gynecologic tumors are available.Keywords: sonography, uterine cavity lesions, endometrial abnormalities, adnexal masses

  3. Circulating Prostate Cells Found in Men with Benign Prostate Disease Are P504S Negative: Clinical Implications

    Directory of Open Access Journals (Sweden)

    Nigel P. Murray


    Full Text Available Introduction. Developments in immunological and quantitative real-time PCR-based analysis have enabled the detection, enumeration, and characterization of circulating tumor cells (CTCs. It is assumed that the detection of CTCs is associated with cancer, based on the finding that CTCs can be detected in all major cancer and not in healthy subjects or those with benign disease. Methods and Patients. Consecutive men, with suspicion of prostate cancer, had blood samples taken before prostate biopsy; mononuclear cells were obtained using differential gel centrifugation and CPCs detecting using anti-PSA immunocytochemistry. Positive samples underwent further classification with anti-P504S. Results. 329 men underwent prostate biopsy; of these men 83 underwent a second biopsy and 44 a third one. Of those with a biopsy negative for cancer, 19/226 (8.4% had CPCs PSA (+ P504S (− detected at first biopsy, 6/74 (8.1% at second biopsy, and 5/33 (15.2% at third biopsy. Men with cancer-positive biopsies did not have PSA (+ P504S (− CPCs detected. These benign cells were associated with chronic prostatitis. Conclusions. Patients with chronic prostatitis may have circulating prostate cells detected in blood, which do not express the enzyme P504S and should be thought of as benign in nature.

  4. Impact of the serum thyroglobulin concentration on the diagnostics of benign and malignant thyroid diseases; Stellenwert des Serum-Thyreoglobulinspiegels bei der Diagnostik benigner und maligner Schilddruesenerkrankungen

    Energy Technology Data Exchange (ETDEWEB)

    Rink, T.; Schroth, H.J. [Abt. fuer Nuklearmedizin, Staedtisches Klinikum, Hanau (Germany); Dembowski, W.; Klinger, K. [Medizinische Klinik, St. Vinzenz Krankenhaus, Hanau (Germany)


    concentrations cannot exclude the respective disorder, a routine Tg determination seems not to be justified in benign thyroid diseases. (orig.) [German] Ziel dieser Studie ist es, neue und bislang zum Teil kontrovers diskutierte Indikationen zur Bestimmung des Thyreoglobulins (Tg) bei unterschiedlichen Schilddruesenerkrankungen in der klinischen Routine zu ueberpruefen. Methoden: Die Studie umfasst folgende Kollektive: 250 gesunde Probanden, 50 Patienten mit euthyreoter Struma diffusa, 161 Patienten mit euthyreoter Knotenstruma (davon 108 operierte Faelle, wobei sich 17 Karzinome fanden), 60 hyperthyreote Patienten mit autonomer Knotenstruma, 150 Patienten mit Thyreoiditis Hashimoto und 30 hyperthyreote Patienten mit M. Basedow. Ergebnisse: Die Grenze des Referenzbereichs errechnete sich zu 30 ng Tg/ml. Die Analyse der diffusen Strumen zeigte eine lineare Abhaengigkeit des Tg-Spiegels von der Schilddruesengroesse, wobei der Erwartungswert in etwa dem Organvolumen in ml entsprach. Knotige Veraenderungen fuehrten zu einem ueberproportionalen Tg-Anstieg, der allerdings einer grossen Varianz unterlag und daher im Einzelfall nur schwer abzuschaetzen war. Von den 17 Patienten mit Schilddruesenkarzinom lag der Tg-Spiegel in 10 Faellen unterhalb des Erwartungswertes, 2 Patienten zeigten einen Tg-Wert von >1000 ng/ml. Bei Autonomien fand sich bezogen auf eine durch Substitution extrem supprimierte Vergleichsgruppe ein signifikant hoeherer mittlerer Tg-Spiegel. Aufgrund der hohen Varianz der Tg-Werte beider Kollektive war die Diagnose der Autonomie anhand der Tg-Bestimmung jedoch kaum moeglich. In der Gruppe mit Thyreoiditis Hashimoto zeigte sich im Vergleich zum Normalkollektiv ein erniedrigter Tg-Spiegel. Bei M. Basedow war die mittlere Tg-Konzentration signifikant hoeher als in der Vergleichsgruppe mit Struma diffusa, dennoch lagen 47% aller Werte noch im Referenzbereich. Schlussfolgerung: Hohe Tg-Werte fuehren bei Verdacht auf Malignitaet, Autonomie oder M. Basedow zu einer hoeheren

  5. Need for thyroidectomy in patients treated with radioactive iodide for benign thyroid disease

    DEFF Research Database (Denmark)

    Villadsen, Mette Jegstrup; Sørensen, Christian Hjort; Godballe, Christian


    Nodular toxic and non-toxic goitres are seen in approximately 15% of Danish women, and the pros and cons of thyroidectomy versus radioiodine (RI) therapy are often discussed. The purpose of this study was to evaluate the type and number of patients treated on the indication of hyperthyroidism...... or benign goitre who did not achieve a sufficient effect of RI therapy and therefore needed thyroidectomy....

  6. 已婚妇女妇科病现况调查及影响因素分析%Analysis Result of Survey and Inlfuencing Factors of Gynecological diseases among Married Women

    Institute of Scientific and Technical Information of China (English)



    Objective Gynecological common disease of married women in the local had been survey and analyzed the affecting factors. Methods During the period from June 2015 to September 2015 questionnaires and gynecological clinical examination of 297 married women, the prevalence and influence factors of independent gynecological disease prevalence rate of gynecological disease statistics. Results Total prevalence rate of 63.97% and the highest prevalence of vaginitis and cervicitis, 31.99% and 29.97% respectively. Independent factors affecting the prevalence of gynecologic diseases include age, education level, age, whether for abortion, whether to take contraceptive measures, whether the understanding of health knowledge. Conclusion Prevalence rate of gynecological diseases among married women in this area is quite high. In the future, it is necessary to strengthen health education for married women and encourage them to conduct regular gynecological examination.%目的:对本地区已婚妇女妇科常见病患病现况进行调查统计,对影响因素进行分析。方法选取2015年6月~2015年9月对本地区297名已婚妇女进行现场问卷调查及妇科临床检查,统计妇科病患病情况及影响妇科病患病率的独立因素。结果297名妇女总患病率为63.97%,阴道炎和宫颈炎患病率最高,分别为31.99%和29.97%。影响已婚妇女妇科病患病的独立因素包括年龄、文化程度、孕次、是否进行过人工流产、是否采取节育措施、是否了解保健知识。结论本地区已婚妇女妇科病患病率较高,在今后的工作中需对已婚妇女加强健康教育并鼓励其定期进行妇科检查。

  7. Analysis of Gynecological Diseases Census of Women of Childbearing Age%育龄妇女妇科病普查情况分析

    Institute of Scientific and Technical Information of China (English)



    Objective:To investigate gynecological diseases census of women of childbearing age. Methods:Retrospective analysis of clinical data of 3458 cases of women of childbearing age in our hospital to participate in gynecological diseases census. Results:The prevalence rate is 45.7%;the main diseases is cervicitis and vaginitis;the prevalence of cervicitis and cervical erosion is down-ward trend with age increases;vaginitis is mainly with bacterial;breast disease is mainly with breast lobular hyperplasia. Conclu-sion:Popularize women's health knowledge, establish regular and abstemious habits, master and do regular breast self-examination, can make the self health care consciousness of women of childbearing age increased significantly, found the disease timely and treat-ment early, reduce the incidence of common diseases of women, improve the overall health and quality of life fundamentally.%  目的:探讨育龄妇女妇科病普查情况。方法:回顾性分析我院参与妇科病普查的3458例育龄妇女的临床资料。结果:患病率为45.7%;病种以宫颈炎、阴道炎为主;宫颈炎、宫颈糜烂患病率随年龄增加呈下降趋势;阴道炎以细菌性为主;乳腺疾病以乳腺小叶增生为主。结论:普及妇女保健知识,建立有规律、有节制的生活习惯,掌握并定期做乳房自检等,可使育龄妇女的自我保健意识显著提高,早期发现疾病并及时治疗,有效降低妇女多发病、常见病的发生率,从根本上提高整体健康水平和生活质量。

  8. 关于盆腔疼痛与妇科疾病的探讨%Discussion on pelvic pain and gynecological diseases

    Institute of Scientific and Technical Information of China (English)



    Chronic pelvic pain (Chronic Pelvie Pain, CPP) occurred in the pelvic cavity within the scope of the chronic non periodic, recurrent attacks of over six for 6 months, causing pain symptoms of dysfunction or drug oroperation treatment, is a common gynecological disorder. In order tofind the way to relieve women pelvic pain, this paper discusses the causes of chronic pelvic pain, pelvic pain and analyzes the relationship between thedisease of Department of gynaecology, thus draws the conclusion:chronic pelvic pain is very common, but the cause of chronic pelvic pain in women is very complex, involving many gynecological diseases, should be targeted to patients with chronic the specific causes of pelvic pain fortargeted prevention and control.%慢性盆腔疼痛(Chronic Pelvie Pain,CPP)是发生在盆腔范围内的慢性无周期性的、反复发作超六6个月,产生功能障碍或需要药物或手术治疗的疼痛症状,是一种常见的妇科症状。为了找到缓解女性朋友盆腔疼痛的方法,本文探讨了慢性盆腔疼痛的病因,分析了盆腔疼痛与妇科疾病的关系,从而得出结论:慢性盆腔疼痛十分常见,而引起女性慢性盆腔疼痛的原因也十分复杂,涉及妇科中的诸多疾病,应针对具体病因对慢性盆腔疼痛患者进行有针对性的防治。

  9. Proteomics in obstetrics and gynecology

    Directory of Open Access Journals (Sweden)

    Seema Lekhwani


    Full Text Available Proteomics helps to understand the basic biological processes critical to normal cellular functions as well as the development of diseases. It identifies the essential components of these processes and exploits these components as targets in the development of new methods to prevent or treat diseases. Proteomics, although in an infancy stage in India, has the potential to complement and further enlarge the wealth of information in medicine, especially in the field of cancer. This article reviews the recent progress in proteomic techniques and their applications in the field of obstetrics and gynecology.

  10. Gynecological Care and Information (United States)

    Cibley, Leonard


    Based upon his experience as gynecologist at the Fernald School, the author suggests a set of criteria for establishing and running a gynecology program at an institution for the mentally retarded. (SBH)

  11. Danish Gynecological Cancer Database

    DEFF Research Database (Denmark)

    Sørensen, Sarah Mejer; Bjørn, Signe Frahm; Jochumsen, Kirsten Marie


    AIM OF DATABASE: The Danish Gynecological Cancer Database (DGCD) is a nationwide clinical cancer database and its aim is to monitor the treatment quality of Danish gynecological cancer patients, and to generate data for scientific purposes. DGCD also records detailed data on the diagnostic measures...... for gynecological cancer. STUDY POPULATION: DGCD was initiated January 1, 2005, and includes all patients treated at Danish hospitals for cancer of the ovaries, peritoneum, fallopian tubes, cervix, vulva, vagina, and uterus, including rare histological types. MAIN VARIABLES: DGCD data are organized within separate...... Danish personal identification number (CPR number). DESCRIPTIVE DATA: Data from DGCD and registers are available online in the Statistical Analysis Software portal. The DGCD forms cover almost all possible clinical variables used to describe gynecological cancer courses. The only limitation...

  12. Gynecological cancer in Indonesia. (United States)

    Aziz, M Farid


    To overview the status of gynecologic cancer in Indonesia. Information regarding Indonesia obtained from World Bank Report and Statistical Yearbook of Indonesia 2007, epidemiological data obtained from Histopathological Data of Cancer in Indonesia 2002, Department of Health-Registry Body of Indonesian Specialist of Pathology Association-Indonesian Cancer Society; Various Hospitals in big Cities in Indonesia. Indonesia is an Archipelago with a total area of 1,922,570.00 km(2), the population is 222,192,000 (2006), the fourth world rank. Female is 49.86% with life expectancy 69 years. Gross National Product per Capita is 690.00 USD. Histopathological report in 2002 revealed that cervical cancer, ovarian cancer and uterine cancer were the most frequent cancer among female, which were the first (2,532 cases), the third (829 cases) and the eighth (316 cases) rank respectively. The peak age for cervical, uterine and ovarian cancer was 45-54 years. HPV 16, 18 were found in 82% of invasive cervical. Data from various academic hospitals in 2007 showed that cervical cancer is the most common malignancy followed by ovary, uterus, vulva and vagina. Five-year survival rate of stage I, II, III, IV cervical cancer were 50%, 40%, 20%, and 0% respectively. Overall five-year survival rate of carcinoma of the ovary was 54.8%. If sub-classified by stage, five-year survival rate are 94.3%, 75.0%, 31%, and 11.7% for stage I, II, III, and IV respectively. Five-year disease-free survival rate of endometrial cancer was 71.9%. Indonesia is the biggest Archipelago with a dense population but the income per capita still low (poor country). The most common gynecologic cancer is cervical cancer, followed by ovarian and uterine cancer. These cancers are included in top ten cancers in Indonesia. HPV 16, 18 were the most cause of cervical cancer. The five-year survival rates are comparable with world report.

  13. Vaginal hysterectomy for benign uterine disease in the laparoscopically confirmed frozen pelvis. (United States)

    Pelosi, M A; Pelosi, M A


    Extensive pelvic adhesions present difficulty with access to the uterus, but they may not account for significant symtomatology, although their dissection may account for a significant deal of morbidity. Results of this study are based on a retrospective analysis of operations by a single surgical team. Eight patients with benign uterine pathology and frozen pelvis diagnosed laparoscopically underwent vaginal hysterectomy. The surgeries were accomplished uneventfully and without significant perioperative morbidity. This approach appears to be an efficient surgical option for hysterectomy, which by-passes the need for and the potential morbidity of an extensive intra-abdominal adhesiolysis by laparotomy or laparoscopy.

  14. Modeling the absorbed dose to the common carotid arteries following radioiodine treatment of benign thyroid disease

    DEFF Research Database (Denmark)

    la Cour, Jeppe Lerche; Hedemann-Jensen, Per; Søgaard-Hansen, Jens


    External fractionated radiotherapy of cancer increases the risk of cardio- and cerebrovascular events, but less attention has been paid to the potential side effects on the arteries following internal radiotherapy with radioactive iodine (RAI), i.e. 131-iodine. About 279 per million citizens...... in the western countries are treated each year with RAI for benign thyroid disorders (about 140,000 a year in the EU), stressing that it is of clinical importance to be aware of even rare radiation-induced side effects. In order to induce or accelerate atherosclerosis, the dose to the carotid arteries has...

  15. Research on the Correlation between Emotional Factors and Gynecological Diseases%情志因素与月经病的相关性研究

    Institute of Scientific and Technical Information of China (English)

    阳少辉; 王小云; 殷一红


    Objective:To investigate the correlation between emotional factors and gynecological diseases. Methods:Adopted research methods of psychometrics, clinical epidemiology and evidence-based medicine, and took psychosocial stress questionnaire for groups (PSSG) as the carrier of study. We made questionnaire survey upon 151 patients in gynecology outpatient from Guangdong provincial TCM hospital, who had obvious emo-tional incentives and were consistent with the diagnostic criteria and brought into criteria, then analyzed the correlation between emotional factors and gynecological diseases. Results:(1)There were differences regarding aspects of overstrain, family&marriage, interpersonal relations, the chil-dren’s future, life environment, individual health, fear, melancholy, anger, being lost in memory, getting oppression, crying, puzzling out and living alone between menstrual disorder group and health comparison group, these differences had statistical significance (P<0.05), The occurrence frequen-cy of the menstrual disorder group was higher than that of the health comparison group. There were differences regarding aspects of happiness, glad-ness, joy, comfort, forgetting as soon as possible, regarding something non-occurrence, being optimistic, nothing, actively changing, and being hu-morous between menstrual disorder group and health comparison group, these differences had statistical significance (P<0.05), the health comparison group was more remarkable than the menstrual disorder group. (2)Family discord marital problem, personal health change, melancholy and anger were dangerous factors of menstrual disorder;children’s prospect, happiness, joy and comfort were protective factors of menstrual disorders. Conclu-sion:Emotional factors plays a very important role in occurrence, development and prognosis of gynecological disease. In the face of adverse life events, people should keep good state of mind and adopt positive coping ways in order to reduce the

  16. The non tumour uptake of (111)In-octreotide creates new clinical indications in benign diseases, but also in oncology. (United States)

    Cascini, G L; Cuccurullo, V; Mansi, L


    The use of somatostatin (SS) analogues in humans takes advantage by the availability of many related chemical forms that can be used for receptor therapy and, after radiolabelling, for diagnostic imaging and radionuclide therapy. The first proposed radiocompound, yet clinically widely diffuse, has been (111)In-octreotide (OCT), followed by positron emission tomography (PET) and beta emitter tracers. The main field of clinical applications is in neuroendocrine tumours (NET), starting by the demonstration of SS receptors (SSR) on the majority of NET, particularly on gastroenteropancreatic (GEP) tumours. Uptake of SS analogues can also be due to a SSR expression on non malignant cells when activated, as lymphocytes, macrophages, fibroblasts , vascular cells. Because of this uptake clinical indications can be found also in active benign diseases, as Grave's ophthalmopathy, rheumatoid arthritis, histiocitosis, sarcoidosis, idiopatic pulmonary fibrosis. Moreover, these cells can also determine the OCT in vivo uptake in tumours non expressing in vitro SSR, as non-snall cell lung cancer (NSCLC). Because of a different kinetic respect to SCLC a differential histotype diagnosis could be obtained. Starting from this premise OCT can also allows radioguided surgery in tumours non expressing SSR. Finally a relevant clinical role can be defined in the a priori recruitment and as marker of therapeutic efficacy in all the therapeutic strategies utilizing SSR, both in malignant and benign diseases.

  17. Indian Experience of Robotics in Gynecology

    Directory of Open Access Journals (Sweden)

    Shailesh P Puntambekar


    Full Text Available Aims: To study the role of robotics in various gynaecological cases, benign and malignant. Materials and Methods: A total number of 80 cases have been analyzed. Operative time, estimated blood loss, hospital stay, complications, conversion rates have been retrospectively studied in all cases. Nodal yield, vaginal margin and paracervical clearance have been studied in all malignant cases. This investigation was conducted at a single minimal access surgery institute. Results: Of total 80 cases, 29 were benign and 51 were malignant cases. In benign cases, total robotic hysterectomies were 24, 2 cases of tubotuboplasty, 1 case of endometriotic cyst excision, 1 case of metroplasty and 1 case of rectovaginal fistula. In 51 cases, 37 of radical hysterectomy, 9 exenterations and 6 were parametrectomy. In benign cases, mean operative time was 80 min, estimated blood loss was 20 ml, mean hospital stay was for 1 day, no major complications and no conversions. In malignant cases, mean operative time was 122 min, estimated blood loss was 50-100ml, 2 cases of ureteric fistulas and no conversions, nodal yield was 30, vaginal margin was 2.5-3.8 cm and para cervical clearance was 3-3.5 cm. Conclusions: Ours is the largest series of robotic surgery in gynecological procedures in India. Benign and malignant cases were addressed robotically showing the feasibility.

  18. Nationwide trends in surgery and radioiodine treatment for benign thyroid disease during iodization of salt

    DEFF Research Database (Denmark)

    Cerqueira, C.; Knudsen, N.; Ovesen, L.


    Objective: Iodization of salt was introduced in Denmark in 1998 because of mild-to-moderate iodine deficiency (ID). The aim of this study was to analyze the utilization rate of surgery and radioiodine therapy for benign thyroid disorders before and after the introduction of iodization, and to stu...... in the region of prior moderate ID, probably as a result of treatment of iodine-induced hyperthyroidism, but the rates ended up being lower than before iodization....... a possible association between the changes and the raised iodine intake. Design: A nationwide register study. Methods: Information on operations and radioiodine treatments for benign thyroid disorders was extracted from nationwide registers in the years 1990 to 2007. Treatment rates are presented for surgery...... and for radioiodine separately, and as a combined rate, both nationwide and split by the regions of prior mild and moderate ID. Results: A total of 65 605 treatments were identified: 26 456 operations and 39 149 radioiodine treatments. In the first years of iodization (1998-2000; rate ratio 2000/1997), the combined...

  19. 间隙连接蛋白43与妇科疾病%Connexin 43 and Gynecological Diseases

    Institute of Scientific and Technical Information of China (English)



    The normal and abnormal expression of connexin play a direct role in the function of cell, tissue , and organ, whereas connexin 43 is the most important gap junction protein.The expression of connexin 43 is increased in uterine tissues, as a low-impedance channel for uterine intermuscular cell contraction.Gap junction channels are subject to the penetration of ions, ensuring the metabolism and behavioral coordination of uterine muscular cell populations.The abnormal expression of connexin 43 is closely associated with the occurrence and progress of uterine myoma,endometriosis,cervical cancer,and other gynecological disorders.%间隙连接蛋白的正常和异常表达,可直接影响细胞及组织、器官的功能状态,其中间隙连接蛋白43是最重要的间隙连接蛋白.在子宫组织中,间隙连接蛋白43水平的升高,为子宫肌细胞间收缩控制提供了低电阻通道,使离子很容易通过间隙连接的通道,保证了子宫肌细胞群在代谢及行为上的协调性.其异常表达,与子宫肌瘤、子宫内膜异位症、宫颈癌等多种妇科疾病的发生、发展有着密切的联系.

  20. Study Syndrome Differentiation and Medication's Law in Fuqingzhu Gynecology about Pregnancy Disease%《傅青主女科》妊娠病辨证用药规律探析

    Institute of Scientific and Technical Information of China (English)

    方圆; 韩延华; 史红敏; 韩延博


    《傅青主女科》是中医妇产科传世之专作,由清代医家傅山(字青主)所著,该书立法严谨灵活,组方精良,且不矜奇立异,疗效卓著,堪称妇科经典之作,是从事妇产科医务工作者的必读之物.该书理论清晰,阐述的疾病机理系统而深刻,辨证用药颇有独到之处,所列方剂经历代妇科医生临床验证疗效彰显.为此,作者试对傅山论治妊娠病的辨证用药特色进行初步探析.%Fuqingzhu Gynecology is masterpiece of expertise of Chinese medicine obstetrics and gynecology, which is written by FU Shan ( styled Qingzhu ), the physician of Qing Dynasty .The book, known as one of obstetric and gynecological classic, is of rigorous and flexible legislation, sophisticated prescription, no maverick and of remarkable efficacy, which is a must-read for obstetric and gynecology workers.Given its clear theory, systematic and profound elaboration about pathogenesis, unique syndrome differentiation and medication and effective prescription confirmed by obstetricians and gynecologists, the author tries to preliminarily study FU Shan's characteristics of syndrome differentiation and medication about pregnancy disease.

  1. Disparities in Gynecological Malignancies

    Directory of Open Access Journals (Sweden)

    Sudeshna eChatterjee


    Full Text Available Objectives: Health disparities and inequalities in access to care among different socioeconomic, ethnic, and racial groups have been well documented in the U.S. healthcare system. In this review, we aimed to provide an overview of barriers to care contributing to health disparities in gynecological oncology management and to describe site-specific disparities in gynecologic care for endometrial, ovarian, and cervical cancer. Methods: We performed a literature review of peer-reviewed academic and governmental publications focusing on disparities in gynecological care in the United States by searching PubMed and Google Scholar electronic databases. Results: There are multiple important underlying issues that may contribute to the disparities in gynecological oncology management in the United States, namely geographic access and hospital based-discrepancies, research-based discrepancies, influence of socioeconomic and health insurance status, and finally the influence of race and biological factors. Despite the reduction in overall cancer-related deaths since the 1990s, the 5-year survival for Black women is significantly lower than for White women for each gynecologic cancer type and each stage of diagnosis. For ovarian and endometrial cancer, black patients are less likely to receive treatment consistent with evidence-based guidelines and have worse survival outcomes even after accounting for stage and comorbidities. For cervical and endometrial cancer, the mortality rate for black women remains twice that of White women. Conclusions: Health care disparities in the incidence and outcome of gynecologic cancers are complex and involve biologic factors as well as racial, socioeconomic and geographic barriers that influence treatment and survival. These barriers must be addressed to provide optimal care to women in the U.S. with gynecologic cancer.

  2. Comparative study of serum zinc concentrations in benign and malignant prostate disease: A Systematic Review and Meta-Analysis. (United States)

    Zhao, Jiang; Wu, Qingjiang; Hu, Xiaoyan; Dong, Xingyou; Wang, Liang; Liu, Qian; Long, Zhou; Li, Longkun


    Many studies have investigated the relationship between serum zinc concentration and prostatic disease, but have shown inconsistent results. Hence, we performed a systematic literature review and meta-analysis to assess the correlation between serum zinc concentration and prostate disease. Systematic literature searches were conducted with PubMed, EMBASE, Science Direct/Elsevier, MEDLINE, CNKI and the Cochrane Library up to June 2015 for studies that involved the relationship between serum zinc concentration and prostate disease. Fourteen studies were identified from the databases. Our results illustrated that the serum zinc concentrations in prostate cancer patients were significantly lower than those in Benign prostatic hyperplasia (BPH) patients and normal controls (SMD (95% CI), -0.94 [-1.57, -0.32]; -1.18 [-1.90, -0.45]). However, the serum zinc concentrations in BPH patients were significantly higher than those in normal controls (SMD (95% CI) 1.77 [0.15, 3.39]). The present study showed that different levels of serum zinc concentrations are correlated with different prostatic disease. Serum zinc concentration may be used as a tool for the diagnosis and screening of prostate disease. But, further studies with well-designed larger sample studies are needed in this field to further clarify the correlation between serum zinc concentration and prostate disease.

  3. Exosomal lncRNAs may to Help Distinguish Prostate Cancer from Benign Disease

    Directory of Open Access Journals (Sweden)

    Mustafa eIsin


    Full Text Available Exosomes are membranous vesicles containing various biomolecules including lncRNAs which are involved in cellular communication and are secreted from many cells including cancer cells. In our study, investigated the exosomal GAS5 and lincRNA-p21 lncRNA levels in urine samples from 30 patients with prostate cancer (PCa and 49 patients with benign prostatic hyperplasia. Quantification of lncRNA molecules was performed by real-time PCR. We observed a significant difference in the exosomal lincRNA-p21 levels between PCa and BPH patients whereas the GAS5 levels did not reveal a difference. Our data suggest that the discriminative potential of exosomal lincRNA-p21 levels may help to improve the diagnostic prediction of the malignant state for patients with prostate cancer.

  4. No gynecologist in town: the gynecological care of women in rural Taiwan

    Directory of Open Access Journals (Sweden)

    Lai LJ


    likely to consult for gynecological diseases (23.8% versus 35.4%; P<0.001 and visit gynecologists (18.7% versus 30.4%; P<0.001 than women in towns with a gynecologist. The disparity existed in each age group. Among 5,189 adult women living in towns without a gynecologist and having gynecological diseases, 78.5% (number [n]=4,074 visited gynecologists out of town, especially for infertility, benign disorders of the uterus and ovaries, gynecological examinations, and contraceptive problems, and by contrast 23.3% (n=1,209 visited nongynecologists in town, most commonly for menopausal disorders, endometriosis and pelvic pain, menstrual disorders and hormonal dysfunction, and genital dysplasia.Conclusion: Gynecological care of rural women was adversely affected by the shortage of gynecologists. The consequences of accessibility in underserved areas deserve further investigation. Keywords: gynecological care, urban–rural health service, women’s health

  5. Monocyte/macrophage and T-cell infiltrates in peritoneum of patients with ovarian cancer or benign pelvic disease

    Directory of Open Access Journals (Sweden)

    Ma Qing


    Full Text Available Abstract Background We previously showed that tumor-free peritoneum of patients with epithelial ovarian cancer (EOC exhibited enhanced expression of several inflammatory response genes compared to peritoneum of benign disease. Here, we examined peritoneal inflammatory cell patterns to determine their concordance with selected enhanced genes. Methods Expression patterns of selected inflammatory genes were mined from our previously published data base. Bilateral pelvic peritoneal and subjacent stromal specimens were obtained from 20 women with EOC and 7 women with benign pelvic conditions. Sections were first stained by indirect immunoperoxidase and numbers of monocytes/macrophages (MO/MA, T cells, B cells, and NK cells counted. Proportions of CD68+ cells and CD3+ cells that coexpressed MO/MA differentiation factors (CD163, CCR1, CXCR8, VCAM1, and phosphorylated cytosolic phospholipase A2 [pcPLA2], which had demonstrated expression in EOC peritoneal samples, were determined by multicolor immunofluorescence. Results MO/MA were present on both sides of the pelvic peritoneum in EOC patients, with infiltration of the subjacent stroma and mesothelium. CD68+ MO/MA, the most commonly represented population, and CD3+ T cells were present more often in EOC than in benign pelvic tumors. NK cells, B cells, and granulocytes were rare. CXCL8 (IL-8 and the chemokine receptor CCR1 were coexpressed more frequently on MO/MA than on CD3+ cells contrasting with CD68+/CD163+ cells that coexpressed CXCL8 less often. An important activated enzyme in the eicosanoid pathway, pcPLA2, was highly expressed on both CD68+ and CD163+ cells. The adherence molecule Vascular Cell Adhesion Molecule-1 (VCAM1 was expressed on CD31+ endothelial cells and on a proportion of CD68+ MO/MA but rarely on CD3+ cells. Conclusion The pelvic peritoneum in EOC exhibits a general pattern of chronic inflammation, represented primarily by differentiated MO/MA, and distinct from that in benign

  6. Sickle cell disease in Saudi Arabia: the phenotype in adults with the Arab-Indian haplotype is not benign. (United States)

    Alsultan, Abdulrahman; Alabdulaali, Mohammed K; Griffin, Paula J; Alsuliman, Ahmed M; Ghabbour, Hazem A; Sebastiani, Paola; Albuali, Waleed H; Al-Ali, Amein K; Chui, David H K; Steinberg, Martin H


    Sickle cell disease (SCD) in Saudi patients from the Eastern Province is associated with the Arab-Indian (AI) HBB (β-globin gene) haplotype. The phenotype of AI SCD in children was described as benign and was attributed to their high fetal haemoglobin (HbF). We conducted a hospital-based study to assess the pattern of SCD complications in adults. A total of 104 patients with average age of 27 years were enrolled. Ninety-six per cent of these patients reported history of painful crisis; 47% had at least one episode of acute chest syndrome, however, only 15% had two or more episodes; symptomatic osteonecrosis was reported in 18%; priapism in 17%; overt stroke in 6%; none had leg ulcers. The majority of patients had persistent splenomegaly and 66% had gallstones. Half of the patients co-inherited α-thalassaemia and about one-third had glucose-6-phosphate dehydrogenase deficiency. Higher HbF correlated with higher rate of splenic sequestration but not with other phenotypes. The phenotype of adult patients with AI SCD is not benign despite their relatively high HbF level. This is probably due to the continued decline in HbF level in adults and the heterocellular and variable distribution of HbF amongst F-cells.

  7. Analysis of common gynecological disease screening utilization in China women%中国妇女人群对妇女常见病普查服务的利用情况分析

    Institute of Scientific and Technical Information of China (English)

    郑睿敏; 李醒; 王临虹; 李丽娟; 狄江丽; 方利文


    Objective To investigate the utilization of common gynecological disease screening service in different women and its influencing factors so as to provide some scientific evidence for further perfecting of common gynecological disease screening. Methods Cluster sampling method was used to select 7261 women from Beijing, Fujian, Shanxi, Hubei, Anhui, Heilongjiang, Xinjiang, Sichuan, Gansu and Guangxi Province from December 2007 to January 2008 for family investigation. Results 3040 women accepted common gynecological disease screening service in the period of 2004 to 2006, and the ratio was 42. 0%. Among many factors influencing the utilization of common gynecological disease screening service, the willingness to accept common gynecological disease screening was the major factor ( OR = 5.022 ). The ratio was lower in jobless women than in administrative / technical staff, workers and peasants ( OR was 1. 597, 2. 292 and 2. 181 respectively ). The lower the education level was, the lower the ratio of screening was( OR = 1.707 ). The ratio of women older than 55 years was lower than that of women aged 35-44 years and 45-54 years ( OR was 1. 683 and 1. 378 respectively ). Conclusion The utilization of common gynecological disease screening service is insufficient in women. Measures should be taken to strengthen their understanding of common gynecological disease screening, to increase the ratio of accepting screening service and to promote the utilization of common gynecological disease screening service.%目的 了解不同妇女人群对妇女病普查服务的利用情况和影响因素,为进一步完善妇女常见病普查工作提供科学依据.方法 于2007年12月至2008年1月选取北京、福建、山西、湖北、安徽、黑龙江、新疆、四川、甘肃、广西为调查现场,采用整群抽样的方法,对7 261名调查对象进行入户调查.结果调查对象中共有3 040名妇女2004至2006年三年期间接受过妇女病普查服务,占42

  8. Analysis on general investigation results of gynecological diseases in 19 081 lowest life guarantee women%19081例低保妇女妇科疾病普查结果分析

    Institute of Scientific and Technical Information of China (English)

    黄文红; 陈丽影


    目的:了解低保妇女妇科疾病患病情况,为制定有效的防治措施提供依据,改善低保妇女的生活质量.方法:采用统一制定的低保妇女免费妇科疾病普查体检表,建立普查对象档案.对19 081例低保妇女进行妇科疾病普查,包括妇科常规检查、阴道分泌物检测、宫颈液基细胞学检查、妇科B型超声检查、乳腺手诊及乳腺彩超.结果:普查低保妇女19 081例,患1种及以上妇科疾病10 198例,患病率为53.45%.在疾病顺位中,前5位依次为阴道炎、宫颈炎、子宫肌瘤、卵巢肿瘤、乳腺肿块.结论:掌握低保妇女的妇科病发病现状,制定相应的干预措施,对低保妇女定期开展妇女病普查普治活动,大力普及生殖健康知识,提高自我保健意识,从而促进和提高低保妇女的生殖健康水平.%Objective; To understand the prevalence of gynecological diseases in lowest life guarantee women, provide a basis for making effective measures for preventing and treating gynecological diseases, and improve the quality of life in lowest life guarantee women. Methods; A uniform table was used for physical examination of gynecological diseases among lowest life guarantee women, then records of respondents were established. A total of 19 081 lowest life guarantee women received general investigation of gynecological diseases, including gynecological routine examination, vaginal secretion detection, cervical liquid - based cytological test, breast palpation, and breast ultrasonography. Results; A total of 19 081 lowest life guarantee women were surveyed, and 10 198 women were found with one or more than one gynecological diseases, the prevalence was 53. 45% ; the top five gynecological diseases were vaginitis, cervicitis, uterine fibroids, ovarian tumor, and breast lumps. Conclusion; Grasping the current situation of occurrence of gynecological disease among lowest life guarantee women, making corresponding intervention measures

  9. Total Pelvic Exenteration for Gynecologic Malignancies

    Directory of Open Access Journals (Sweden)

    Elisabeth J. Diver


    Full Text Available Total pelvic exenteration (PE is a radical operation, involving en bloc resection of pelvic organs, including reproductive structures, bladder, and rectosigmoid. In gynecologic oncology, it is most commonly indicated for the treatment of advanced primary or locally recurrent cancer. Careful patient selection and counseling are of paramount importance when considering someone for PE. Part of the evaluation process includes comprehensive assessment to exclude unresectable or metastatic disease. PE can be curative for carefully selected patients with gynecologic cancers. Major complications can be seen in as many as 50% of patients undergoing PE, underscoring the need to carefully discuss risks and benefits of this procedure with patients considering exenterative surgery.

  10. Acute gynecologic disorders in adolescents: CT findings

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Young Tong [Soonchunhyang Univ. Cheonan Hospital/Soonchunhyang Univ. College of Medicine, Cheonan (Korea, Republic of)


    Gynecologic disorders that cause pelvic pain in adolescents include hemorrhagic ovarian cysts, rupture or torsion of ovarian cyst or tumors, hematocolpos caused by vaginal obstruction, endometriosis, cystic uterine adenomyosis, pelvic inflammatory diseases, and pelvic inclusion cyst. The use of CT for the evaluation of pelvic pain is increasing, and CT is useful if ultrasound findings are not decisive and the lesion is extensive.

  11. Your Daughter's First Gynecological Exam (United States)

    ... 1- to 2-Year-Old Your Daughter's First Gynecology Visit KidsHealth > For Parents > Your Daughter's First Gynecology Visit A A A What's in this article? ... medical care. The American College of Obstetrics and Gynecology (ACOG) recommends that young women have their first ...

  12. Spontaneous activity in electromyography may differentiate certain benign lower motor neuron disease forms from amyotrophic lateral sclerosis. (United States)

    Jokela, Manu E; Jääskeläinen, Satu K; Sandell, Satu; Palmio, Johanna; Penttilä, Sini; Saukkonen, Annamaija; Soikkeli, Raija; Udd, Bjarne


    There is limited data on electromyography (EMG) findings in other motor neuron disorders than amyotrophic lateral sclerosis (ALS). We assessed whether the distribution of active denervation detected by EMG, i.e. fibrillations and fasciculations, differs between ALS and slowly progressive motor neuron disorders. We compared the initial EMG findings of 43 clinically confirmed, consecutive ALS patients with those of 41 genetically confirmed Late-onset Spinal Motor Neuronopathy and 14 Spinal and Bulbar Muscular Atrophy patients. Spontaneous activity was more frequently detected in the first dorsal interosseus and deltoid muscles of ALS patients than in patients with the slowly progressive motor neuron diseases. The most important observation was that absent fibrillations in the first dorsal interosseus muscle identified the benign forms with sensitivities of 66%-77% and a specificity of 93%. The distribution of active denervation may help to separate ALS from mimicking disorders at an early stage.

  13. 147例小儿妇科疾病的临床分析%A clinical analysis of gynecological diseases in 147 children

    Institute of Scientific and Technical Information of China (English)

    谭智慧; 张怡; 张瑜


    ObjectiveTo study the clinical features of gynecological diseases in hospitalized children.Methods A retrospective analysis was performed for the clinical data of 147 children with gynecological diseases who were hospitalized and treated in the department of gynecology.ResultsAmong the 147 children, ovarian tumors were most common (53 cases, 36.1%), followed by reproductive tract dysplasia or malformation (29 cases, 19.7%), adolescent dysfunctional uterine bleeding (18 cases, 12.2%), traumatic injury in the vulva/vagina (15 cases, 10.2%), and vaginal foreign body (8 cases, 5.4%). The main symptoms of ovarian tumors includedabdominal pain and abdominal or pelvic mass. Progressive abdominal pain was a main symptom in children with reproductive tract dysplasia or malformation. The children with adolescent dysfunctional uterine bleeding manifested as irregular or a lot of vaginal bleeding. The children with ovarian tumors and reproductive tract malformation or dysplasia were given surgical treatment, and those with adolescent dysfunctional uterine bleeding were given different sex hormones based on their clinical manifestations and endometrial thickness. Eight children with vaginal foreign body underwent hysteroscopy for vaginal examination, and the foreign body was successfully removed without the damage of the hymen. One patient with tubal pregnancy underwent laparoscopic tubal pregnancy debridement. One patient with hydatid mole was diagnosed with invasive hydatid mole after complete curettage of uterine cavity and then received chemotherapy.ConclusionsThe top three gynecological diseases in children are ovarian tumors, reproductive tract dysplasia or malformation, and adolescent dysfunctional uterine bleeding. Common chief complaints of the patients include abdominal pain, abdominal masses, and irregular vaginal bleeding. Diagnosis and treatment should fully consider the physiological and reproductive features of children and give full play to the advantages of

  14. Fluorescence diagnostics in oncological gynecology (United States)

    Belyaeva, Ludmila A.; Adamyan, Leila V.; Kozachenko, Vladimir P.; Stratonnikov, Alexander A.; Stranadko, Eugene F.; Loschenov, Victor B.


    The method of fluorescent diagnostics (FD) of tumors is a promising tool that may allow to increase sensitivity of tumor detection especially at initial stages. One of the most promising photosensitizers today is 5-aminolevulinic acid (5-ALA) that, actually, is not photosensitizer itself but precursor of protoporphyrin IX (PpIX). This paper deals with cancer diagnostics in gynecology by means of ALA-induced Pp IX laser-fluorescence spectroscopy. The tissue fluorescence spectra in vivo were studied in patients with various pathologies of ovaries, uterine and vulva after 5-aminolevulinic acid administration. It was shown that different pathologies varies in accumulation of Pp IX. Coefficient of fluorescence kf for normal tissue is not high, but exceptions are endometrium and mucous membrane of uterine tubes. Benign tumors of uterus and ovary have low values of kf, but polyps of endometrium exhibit high kf. Optical express-biopsy is important for diagnosis of ovarian cancer and micrometastatic spread. Coefficients of diagnostic contrast were determined for cancer of endometrium, cervical cancer, vulvar cancer.

  15. 西藏左贡县医院妇科门诊疾病谱分析%Spectrum of disease at gynecology outpatient department in Zuogong county hospital

    Institute of Scientific and Technical Information of China (English)

    王玢; 洛松次登; 万荣; 冯正勇; 扎西松姆; 德尕


    目的:通过分析西藏左贡县医院妇科门诊妇科疾病谱,探讨当地妇女妇科疾病的发病特点,为制定预防和治疗措施提供依据。方法:回顾性分析2010年7月至2010年9月期间左贡县医院妇科门诊就诊病例1183例。结果:妇科疾病发病率前5位顺次为:慢性宫颈炎(41.50%)、阴道炎(36.01%)、盆腔炎(14.62%)、子宫肌瘤(3.63%)、功能性子宫出血(2.87%)。同时患有2种以上炎症性疾病的占33.13%,妇科炎症性疾病总发病率92.13%,明显高于国内报道;子宫肌瘤及功能性子宫出血发病率均低于国内报道。结论:西藏左贡县受特殊地理环境及特殊民族风俗影响,女性性生活开始较早、分娩次数较多、卫生经济状况较差,妇科炎症性疾病发病率较高,特别是两种以上炎症同时发病较多。做好计划生育的宣教、降低人工流产率、减少分娩次数、加强流产后及产后妇女的保健、加大对于基层妇产科专业人员的帮扶等,对于降低妇科炎症性疾病发病率、提高当地妇女生殖健康水平很有必要。%Objectives:To discuss the characteristics of female diseases by means of analyzing the women diseases spectrum at gynecology outpatient department of Zuogong county hospital,so as to provide evidence for making precautionary and therapeutic measures.Methods:1 1 83 patients at gynecology department of Zuogong county hospital were retrospectively analyzed From July to September in 201 0.Results:The top five female diseases with the highest morbidity were chronic cervicitis (41 .5%),vaginitis (36.01 %),pelvic infection (1 4.62%), myoma of uterus (3.63%)and dysfunctional uterus bleeding (2.87%).About 33.1 3% objects suffered from two kinds of inflammatory gynecologic diseases.The total morbidity of female inflammatory diseases was 92.1 3%,which was superior to that reported domestically,otherwise the

  16. Global epidemiology of hysterectomy: possible impact on gynecological cancer rates

    DEFF Research Database (Denmark)

    Hammer, Anne; Rositch, Anne; Kahlert, Johnny Abildgaard;


    Despite the fact that hysterectomy is the most common surgical procedure worldwide in gynecology, national reporting of the incidence rate of gynecological cancers rarely removes the proportion no longer at risk of the disease from the population-at-risk-denominator (ie. women who have had...... a hysterectomy). The incidence rate of gynecological cancers is thus likely underestimated. Since hysterectomy, as well as oophorectomy, incidence varies across countries, age, and over time, meaningful comparison of gynecological cancer incidence rates may be compromised. Without accurate estimates...... of gynecological cancer incidence rates, performed via removing the proportion of hysterectomized or oophorectomized women from the population-at-risk-denominator, the impact of prevention strategies may be masked or misinterpreted. Furthermore, since national cervical cancer screening guidelines are at least...

  17. Gynecologic cancers in pregnancy

    DEFF Research Database (Denmark)

    Amant, Frédéric; Halaska, Michael J; Fumagalli, Monica;


    insights and more experience were gained since the first consensus meeting 5 years ago. METHODS: Members of the European Society of Gynecological Oncology task force "Cancer in Pregnancy" in concert with other international experts reviewed the existing literature on their respective areas of expertise...

  18. Robotics in gynecologic surgery. (United States)

    Frick, A C; Falcone, T


    Robotic surgery has evolved from an investigational surgical approach to a clinically useful adjunct in multiple surgical specialties over the past decade. Advocates of robotic-assisted gynecologic surgery revere the system's wristed instrumentation, ergonomic positioning, and three-dimensional high-definition vision system as significant improvements over laparoscopic equipment's four degrees of freedom and two-dimensional laparoscope that demand the surgeon stand throughout a procedure. The cost, lack of haptic feedback, and the bulky size of the equipment make robotics less attractive to others. Studies evaluating outcomes in robotic-assisted gynecologic surgery are limited. Multiple small retrospective studies demonstrate the safety and feasibility of robotic hysterectomy. With increased surgeon experience, operative times are similar to, or shorter than, laparoscopic cases. Robotic assistance can facilitate suturing in laparoscopic myomectomies, and is associated with decreased blood loss and a shorter hospital stay, although may require longer operative times. Robotic assistance has also been applied to multiple procedures in the subspecialties of infertility, urogynecology and gynecologic oncology with good success and relatively low morbidity. However, further research is warranted to better evaluate the relative benefits and costs of robotic assisted gynecologic surgery.

  19. 清远市农村妇女妇科疾病患病状况的现况调查%Investigation on the current situation of prevalence of gynecological diseases among the rural women in Qingyuan city

    Institute of Scientific and Technical Information of China (English)

    伍杏梅; 张小新; 陈建华; 肖淑君; 向杏群; 沈锦红; 朱春燕


    目的:了解清远地区农村妇女常见妇科病的流行状况及流行特征,为建立有效的农村妇女保健运作模式提供依据.方法:采用整群随机抽样的方法抽取研究对象,抽中清远市贫困地区9个镇的年龄为18 ~59岁的全体已婚农村妇女作为调查对象.结果:农村妇女妇科病患病率为58.63%;患病前3位顺位为阴道炎、宫颈炎、卵巢肿瘤;不同年龄组患病率有统计学差异,41~50岁年龄组患病率最高(40.21%).结论:贫困地区妇女妇科疾病患病率较高,应建立有效的农村妇女保健运作机制,促进农村妇女的生殖健康.%Objective; To understand the current situation and characteristics of prevalence of common gynecological diseases a-mong the rural women in Qingyuan city, provide a basis for establishing an effective rural maternal health care mode. Methods: Cluster random sampling method was used to select study objects, all the married rural women aged 18 -59 years old in nine towns of poverty - stricken area of Qingyuan city were selected as respondents. Results; The prevalence of gynecological diseases among the rural women was 58. 63% , the top three gynecological diseases were vaginitis , cervicitis, and ovarian tumors; there was significant difference in the prevalence of gynecological diseases among different age groups, the prevalence among 41 -50 - year - old group was the highest (40. 21% ) . Conclusion; The prevalence of gynecological diseases among the rural women in poverty - stricken area was relatively high, effective rural maternal health care mode should be established to promote reproductive health of rural women.

  20. Complement Factor B Mutations in Atypical Hemolytic Uremic Syndrome—Disease-Relevant or Benign? (United States)

    Marinozzi, Maria Chiara; Vergoz, Laura; Rybkine, Tania; Ngo, Stephanie; Bettoni, Serena; Pashov, Anastas; Cayla, Mathieu; Tabarin, Fanny; Jablonski, Mathieu; Hue, Christophe; Smith, Richard J.; Noris, Marina; Halbwachs-Mecarelli, Lise; Donadelli, Roberta; Fremeaux-Bacchi, Veronique


    Atypical hemolytic uremic syndrome (aHUS) is a genetic ultrarare renal disease associated with overactivation of the alternative pathway of complement. Four gain-of-function mutations that form a hyperactive or deregulated C3 convertase have been identified in Factor B (FB) ligand binding sites. Here, we studied the functional consequences of 10 FB genetic changes recently identified from different aHUS cohorts. Using several tests for alternative C3 and C5 convertase formation and regulation, we identified two gain-of-function and potentially disease-relevant mutations that formed either an overactive convertase (M433I) or a convertase resistant to decay by FH (K298Q). One mutation (R178Q) produced a partially cleaved protein with no ligand binding or functional activity. Seven genetic changes led to near-normal or only slightly reduced ligand binding and functional activity compared with the most common polymorphism at position 7, R7. Notably, none of the algorithms used to predict the disease relevance of FB mutations agreed completely with the experimental data, suggesting that in silico approaches should be undertaken with caution. These data, combined with previously published results, suggest that 9 of 15 FB genetic changes identified in patients with aHUS are unrelated to disease pathogenesis. This study highlights that functional assessment of identified nucleotide changes in FB is mandatory to confirm disease association. PMID:24652797

  1. Investigating the role of Sirt1-modulated oxidative stress in relation to benign paroxysmal positional vertigo and Parkinson's disease. (United States)

    Tsai, Kun-Ling; Cheng, Yuan-Yang; Leu, Hsin-Bang; Lee, Yi-Yen; Chen, Tzeng-Ji; Liu, Ding-Hao; Kao, Chung-Lan


    Benign paroxysmal positional vertigo (BPPV) is one of the most frequently encountered primary complaints in dizziness clinics. The incidence of BPPV has been proven to increase with age. The relationship between BPPV and another neurodegenerative disease, Parkinson's disease (PD), has not been previously discussed. This study aimed to investigate the relationship of BPPV and PD with oxidative stress. A total of 30,811 subjects participated in our cohort study. The study cohort comprised 5057 BPPV patients and a comparison cohort of 25,754 nonBPPV patients. SIRT1 axis gene expression was investigated in BPPV patient blood samples and a PD cell model of 6-hydroxydopamine (6-OHDA)-treated PC-12 cells to elucidate the potential in vitro and in vivo mechanisms of degeneration in PD and BPPV. Our data suggest that BPPV patients with histories of head injuries show a significantly higher hazard to develop subsequent PD (hazard ratio, 3.942; confidence interval, 1.523-10.205, p = 0.005). We also observed that oxidative status is increased in blood samples from patients with BPPV. Our in vitro study suggests that SIRT1 function is inhibited by oxidative stress, which thereby promotes 6-hydroxydopamine-induced cell death. We conclude that BPPV is independently associated with an increased risk of PD. This finding may be attributed to oxidative stress-mediated inhibition of SIRT1 expression levels.

  2. Assessment of mothers’ satisfaction with the care of maternal care in Specialized Educational-Medical Centers in obstetrics and gynecological disease in Northwest, Iran

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    Simin Taghavi


    Full Text Available Introduction: Patients satisfaction includes the assessment of healthcare which she/he received. This study aims at assessment of mothers’ satisfaction with the care of maternal care in Specialized Educational-Medical Centers in obstetrics and gynecological disease in Northwest, Iran. Methods: In an analytic-descriptive cross-sectional study, 1000 female patients who admitted in educational-medical centers of Northwest were studied during a 2 years period (2010-2012. They asked to fill a 34-item closed-answer questionnaire (ranking from very unsatisfied to very satisfied responses following their discharge. Validity of the questionnaire was improved by gynecologist’s experts comments, and reliability of the questionnaire were assessed by test-retest methods (α = 0.946. Results: The satisfaction score (satisfied or very satisfied responses were 61.2, 55.8, 61.8 and 59.5 percent for admitting process, primary care services, treatments and therapeutic interventions and overall, respectively. The satisfaction score for access to doctors was highest in the morning and lowest at the night shifts. The satisfaction score about the personnel’s behavior was lowest during the night shifts. The satisfaction score about the residents’ behavior was highest for the morning shifts. There was no significant difference between the three working shifts regarding psychological feelings, humanitarian respect, and issues like nutrition and private and public hygiene. There was a significant direct correlation between the mean score of satisfaction and patients’ age (Spearman’s rho = 0.117, P < 0.001. Conclusion: The satisfaction level of patients hospitalized in Northwest of Iran's Hospitals was intermediate. Planning new strategies in this regard with emphasis on the main limitations may improve the satisfaction rate in the future.

  3. Sonographic Findings of Benign Breast Diseases, A Study of 111 Cases in Iranian Center for Breast Cancer

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    N. sedighi


    Full Text Available Introduction & Background: Benign lesions are very common in breast. The most important consideration for physicians is to differentiate benign processes from malignant ones .Hence the clinicians and radi-ologists both wish to differentiate them even before surgical procedures. The Iranian Center for Breast Cancer linked to Jahad Daneshgahi Center is a referral place for patients with breast complaints. Patients & Methods: Retrospective study of sonographic findings of 111 patients with benign patho-logic diagnosis revealed 72.1% accuracy for sonogra-phy in diagnosing benign masses. In 31 cases (27.9%, the sonographic diagnosis was incorrect. Among the different benign lesions, the most common lesions were cysts, fibradenomas, and fibrocystic changes with respective sonographic accuracy of 100%, 90%, and 62.5%. Results: It shows that sonography has a high sensitiv-ity for diagnosis of benign breast lesions and this sen-sitivity is higher in cysts and fibradenomas which are the most common benign pathologies of breast. Conclusion: As a result, in this center sonography is an imaging modality for evaluating benign breast le-sion especially in young patients with dense breasts and palpable masses. Its unique role in diagnosis of the cysts is valuable especially to avoid repeated biopsies.

  4. Gynecological cancer alarm symptoms:

    DEFF Research Database (Denmark)

    Balasubramaniam, Kirubakaran; Ravn, Pernille; dePont Christensen, René


    INTRODUCTION: To determine the proportion of patients who were referred to specialist care after reporting gynecological cancer alarm symptoms to their general practitioner. To investigate whether contact with specialist care was associated with lifestyle factors or socioeconomic status. MATERIAL...... contact with specialist care were obtained from the National Patient Register and the National Health Insurance Service Registry, while information about socioeconomic status was collected from Statistics Denmark. Main outcome measures were percentages of patients having contact with specialist care...... and odds ratios (ORs) for associations between specialist care contact, lifestyle factors and socioeconomic status. RESULTS: The study included 25 866 non-pregnant women; 2957 reported the onset of at least one gynecological cancer alarm symptom, and 683 of these (23.1%) reported symptoms to their general...

  5. Gynecology in Pompeii. (United States)

    Bliquez, L J


    By tracing the proveniences of the Greco-Roman surgical instruments in the Naples Museum, it is possible to identify sites in Pompeii where surgeons were active. Some of these sites attract special attention owing to the intricacy and quantity of the tools in their instrumentaria. In a few cases a surgical specialty is apparent. Into this category fall three houses that can be associated with the practice of gynecology.

  6. Robotics in gynecology. (United States)

    Falcone, Tommaso; Goldberg, Jeffrey M


    The surgical robot has the potential to enable a laparoscopic approach to procedures that are presently performed by laparotomy due to the technical difficulties intrinsic to laparoscopy. The use of the current robot prototypes are not cost-effective for gynecologic procedures that are already performed by laparoscopy. The rapid evolution of robotics will likely allow for more widespread application in all surgical specialties in the future.

  7. Epidemiological profile and postoperative complications of women undergoing gynecological surgery in a reference center in the northern brazilian legal amazon

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    Sônia Maria Coelho


    Full Text Available Objective: To evaluate the epidemiological profile and the operative complications of patients undergoing gynecological operations for benign diseases in a tertiary public hospital in the state of Roraima, Brazil. Methods: We conducted a retrospective survey through the analysis of 518 records of patients submitted to gynecological operations between January and June 2012. We included the three major operations during this period (n = 175: hysterectomy, colpoperineoplasty and suburethral sling placement. We excluded 236 cases of tubal ligation and 25 cases where it was not possible to access to medical records. Results: The mean age was 47.6 years; the education level of most patients was completed junior high (36.6%; 77% were from the State capital, 47.4% were in stable relationships and 26.3% were housewives. The majority of patients had given birth three or more times (86.6%, with previous vaginal delivery in 50.2%, and cesarean delivery, 21%. The main diagnostic indications for surgical treatment were uterine myoma (46.3%, urinary incontinence (27.4% and genital dystopias (17.7%. We found three cases (1.7% of high-grade intraepithelial lesions on Pap smear. The most common procedure was total hysterectomy (19.8%, 15.5% vaginally. The most common complication was wound infection (2.2%. Conclusion: Women undergoing gynecological operations due to benign disease had a mean age of 47 years, most had levels of basic education, came from the capital, were in stable relationships, predominantly housewives, multiparous and showed low operative complication rates.

  8. A very high amylase can be benign in paediatric Crohn's disease. (United States)

    Venkataraman, Devasmitha; Howarth, Lucy; Beattie, Robert Mark; Afzal, Nadeem Ahmad


    A 12.5-year-old boy with Crohn's disease with abdominal pain had a raised amylase of 1835 IU/l with normal lipase levels. Ultrasound showed no evidence of inflammation of pancreas. The amylase to creatinine clearance ratio, was 0.8% (reference interval 2%-5%; >6% consistent with acute pancreatitis; amylase with a corresponding reduced clearance of amylase in his urine, positively supporting the diagnosis of macroamylasemia. Macroamylasemia has no clinical significance other than misdiagnosis as acute pancreatitis. Awareness of this condition is important and a positive diagnosis should always be made to avoid unnecessary changes in treatments.

  9. 10-year experience of CO2-laser application in ambulance gynecology (United States)

    Stachanov, Michael L.; Masychev, Victor I.; Velsher, Leonid Z.; Kirkin, Vladimir V.; Zhashkov, Roman V.; Kocharian, Emilia A.


    CO2-laser surgical systems have come to stay in everyday practice of modern physicians and are successfully used in colposcopic and laparoscopic surgery. Results, obtained in ambulance gynecology are especially impressing. CO2- laser provides high medical- and cost-effective treatment. Presented work describes many-years experience of CO2- laser application. 439 patients with various vulvaric and cervix diseases were operated within this period. Laser beam parameters were selected according to requirements ((tau) =4 J/cm2) treatment without carbonization. Analyses of the results showed that the laser successfully destructs uterine cervix erosion, endocervicosis, dysplasia, leukoplakia, eritoplakia of uterine cervix, various benignant pathologies and focus degenerative process in ambulate conditions.

  10. Copper as ancillary diagnostic tool in preoperative evaluation of possible papillary thyroid carcinoma in patients with benign thyroid disease. (United States)

    Dragutinović, Vesna V; Tatić, Svetislav B; Nikolić-Mandić, Snežana D; Tripković, Tatjana M; Dunđerović, Duško M; Paunović, Ivan R


    Preoperative diagnosis of papillary thyroid carcinoma (PTC) comprises numerous diagnostic procedures which are mostly applicable in tertiary institutions. Normal thyroid function depends on the presence of many trace elements and copper (Cu) and zinc (Zn) are some of those. The study is based on retrospective review of 118 patients with preoperatively diagnosed benign thyroid disease (BTD) and 12 with PTC, who underwent thyroid surgery at the Center for Endocrine Surgery Clinical Center of Serbia, Belgrade, between 2010 and 2012. The objective was to evaluate concentrations of Cu and Zn in serum as possible prediction markers for PTC in patients who underwent surgery for preoperatively diagnosed BTD. Concentrations of Cu and Zn ions in serum were measured using atomic absorption spectrophotometer. Data were analyzed using methods of descriptive statistics, Anova and t-test (p papillary microcarcinoma-mPTC in 13 (11.0%) of BTD patients. The concentrations of Cu ions in serum of PTC patients as well as in serum of patients with mPTC were significantly higher than in serum of BTD patients (p thyroid surgery can be useful, easy available, and a low-cost tool in prediction of preoperatively undiagnosed PTC in patients with BTD.

  11. Benign Prostatic Hyperplasia: A New Metabolic Disease of the Aging Male and Its Correlation with Sexual Dysfunctions

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    Giovanni Corona


    Full Text Available Metabolic syndrome (MetS is a well-recognized cluster of cardiovascular (CV risk factors including obesity, hypertension, dyslipidemia, and hyperglycaemia, closely associated with an increased risk of forthcoming cardiovascular disease and type 2 diabetes mellitus. Emerging evidence indicates that benign prostate hyperplasia (BPH and its related lower urinary tract symptoms (LUTS represent other clinical conditions frequently observed in subjects with MetS. Several modifiable factors involved in MetS determinism, such as inadequate diet, lack of physical exercise, and smoking and drinking behaviours are emerging as main contributors to the development of BPH. The pathogenetic mechanisms underlying the connection between MetS and BPH have not been completely clarified. MetS and its components, hypogonadism, and prostate inflammation probably play an important role in inducing BPH/LUTS. Although historically considered as a “normal” consequence of the aging process, BPH/LUTS should now be faced proactively, as a preventable disorder of the elderly. Type of diet and level of physical activity are now considered important factors affecting prostate health in the aging male. However, whether physical exercise, weight loss, and modifications of dietary habit can really alter the natural history of BPH/LUTS remains to be determined. Further research is advisable to better clarify these points.

  12. In-vivo isotope diagnosis and radioiodine therapy of benign thyroid diseases

    Energy Technology Data Exchange (ETDEWEB)

    Spesshardt, K. (Sankt-Vincentius-Krankenhaeuser, Karlsruhe (Germany, F.R.). Radiologische Abt. mit Strahlentherapie und Nuklearmedizin)


    In-vivo diagnoses of thyroid diseases can be carried out using /sup 123/I, /sup 131/I, and /sup 99/sup(m)Tc-pertechnetate. For the thyroid scintiscan, /sup 99/sup(m)Tc-pertechnetate or /sup 123/I are used. Some functional parameters can be determined using /sup 99/sup(m)Tc-pertechnetate, but iodine is more accurate, so that thyroid clearance examinations with /sup 123/I are rapidly gaining importance. However, the iodine turnover in the thyroid can only be determined by a several-days' test using /sup 131/I. The available techniques of diagnosis are employed in several steps. Most thyroid diseases can already be diagnosed on the basis of the hormone parameters and a thyroid scan; otherwise, a TRH test and suppression and functional studies will be necessary. Treatment of enthyroid struma is limited to inoperable cases with functional blockage or compression of the trachea. In the treatment of diffuse hyperthyroidism, doses should be exact enough to counteract the hyperthyroid metabolism without inducing hypothyroidism. With exact doses, a second radioiodine therapy will only be necessary in about 40% of all cases. High doses should not be applied in the treatment of hyperthyroidism unless it is a case of excessive clinical hyperthyroid somatics as the risk of hypothyroidism is high. The diagnostic problem of autonomous adenoma is the highly varying hormone activity. The intention of radioiodine therapy here is a functional elimination of the autonomous adenoma. Radioiodine resection is indicated in cases where there are several small autonomous adenomas or where the operability of the patient is limited.

  13. Laparoscopic splenectomy in children with benign hematological diseases: Leaving nothing behind policy

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    Mohammad Gharieb Khirallah


    Full Text Available Context: Laparoscopic splenectomy (LS is considered the standard approach for the treatment of children with nonmalignant hematological diseases due to the advances in the minimal invasive surgery over the conventional splenectomy (CS. Different techniques are involved in the operation to secure the hilum. Aim: The use of (Ligasure™ is a safe, effective, less time consuming and with less complications rate. Materials and Methods: Sixty children (33 with thalassemia, 20 with immune thrombocytopenic purpura [ITP] and seven with spherocytosis were operated during the period from June 2007 to December 2014. These children had undergone LS using (Ligasure™. Three ports were used in small-sized spleens while four ports were used in large spleens. Results: There were 60 children (37 girls and 23 boys with a mean age of 10.2 years had LS using Ligasure™ with mean operative time of 85 min for cases of ITP and 120 min for other cases. There was no mortality. Two cases were converted to CS. Conclusions: Use of Ligasure™ alone was safe, less time consuming with less complications rates.

  14. Measuring disease-specific health status in men with benign prostatic hyperplasia. Measurement Committee of The American Urological Association. (United States)

    Barry, M J; Fowler, F J; O'Leary, M P; Bruskewitz, R C; Holtgrewe, H L; Mebust, W K


    In preparation for an outcomes study of benign prostatic hyperplasia (BPH), two measures of disease-specific health status were developed to supplement a symptom score and overall health status measures. The symptom problem index (SPI) captures how troublesome patients find their urinary symptoms. The BPH impact index (BII) measures how much their urinary problems affect various domains of health. A prospective revalidation of the refined instruments (N = 108 BPH patients and 50 controls) documented that both indices had good internal consistency (Cronbach's alpha = 0.88 and 0.79, respectively) and test-retest (r = 0.88 for both) reliabilities, correlated strongly with symptom scores (r = 0.86 and 0.77), and discriminated between BPH and control subjects (receiver-operating characteristic areas = 0.87 and 0.85, respectively). These indices were nearly as responsive as symptom scores in 50 men actively treated for BPH, and much more responsive than a non-disease-specific General Health Index (GHI), a Mental Health Index (MHI), and an Activity Index (AI). Finally, these measures capture most of the health status significance of BPH symptoms. In linear regression models constructed to predict scores on the GHI, MHI, and AI, symptom scores added little explanatory power to the SPI and, particularly, to the BII. These measures help clarify how BPH affects overall health status and function. Such measures have an important role to play in studies of the outcomes of treatment for BPH, and probably for other conditions that interfere with health status and function.

  15. Elective pneumonectomy for benign lung disease: modern-day mortality and morbidity. (United States)

    Conlan, A A; Lukanich, J M; Shutz, J; Hurwitz, S S


    This retrospective study of elective pneumonectomy for complicated inflammatory lung disease was done to define modern-day mortality and morbidity. One hundred twenty-four patients received elective pneumonectomy. Patient ages ranged from 6 months to 71 years. Past, recurrent, or new pulmonary tuberculosis was present in 107 patients (86.3%). Clinical presentation involved recurrent infections or severe suppurative sequelae (abscess, empyema). Forty-seven patients had chronic hemoptysis and 25 patients had past or recent massive hemoptysis (> 600 ml of hemoptysis fluid within 24 hours). Nutritional deficiencies were common. One hundred six patients (85.5%) had end-stage destroyed lungs. Evaluative bronchoscopy showed inflammatory endobronchial changes in 106 patients (85.5%), bronchial strictures in 4, and indolent endobronchial tumor in 2. Lung separation was by double-lumen tube in 96 patients, single lung-single tube in 6, bronchus blocker in 6, and prone posture in 9. Extrapleural pneumonectomy was done in 83 patients (66.9%). Fifty-seven of these procedures were left sided and 26 were right sided. Standard transpleural pneumonectomy was done in 41 patients (33.1%): 30 left sided and 11 right sided. Nine pneumonectomies were conducted with the patient in the prone position. Four patients had completion pneumonectomy. Hospital mortality was three deaths (2.4%). Morbidity included postpneumonectomy empyema in 19 patients (15.3%). Seven postoperative bronchopleural fistulas occurred. Empyema in most patients was managed by open pleural drainage (thoracostoma) and later space closure. Pneumonectomy proved effective therapy with low mortality but postpneumonectomy empyema posed serious morbidity.

  16. Radiotherapy of splenomegaly. A palliative treatment option for a benign phenomenon in malignant diseases

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    Kriz, Jan; Mueller, Rolf-Peter; Eich, Hans Theodor [Koeln Univ. (Germany). Dept. of Radiation Oncology; Micke, Oliver [St. Franziskus Hospital, Bielefeld (Germany). Dept. of Radiation Oncology; Bruns, Frank [Medical School Hannover (Germany). Dept. of Radiation Oncology; Haverkamp, Uwe [Clemens Hospital, Muenster (Germany). Dept. of Radiation and Radiation Oncology; Muecke, Ralph; Schaefer, Ulrich [Hospital Lippe (Germany). Dept. of Radiation Oncology; Seegenschmiedt, Heinrich [Center of Radiotherapy, Hamburg (Germany)


    Purpose: Since the 20{sup th} century, radiotherapy (RT) has been used for treatment of symptomatic splenomegaly (SM). SM occurs in association with hematologic disorders. The purpose of this analysis was to determine the indication, treatment concepts, and efficiency of RT. Material and Methods: Clinical features, treatment concepts, and outcome data during the past 20 years were analyzed. Endpoints were pain relief, symptomatic and hematological response, and treatment-related side effects. Results: From 1989-2009, a total of 122 patients received 246 RT courses because of symptomatic SM. Overall 31 patients had chronic myelogenous leukemia (CML), 37 had chronic lymphocytic leukemia (CLL), 23 had osteomyelofibrosis (OMF), 17 had polycythemia vera (PV), 5 had acute myelogenous leukemia, 4 had idiopathic thrombocytopenic purpura (ITP), 3 had non-Hodgkin lymphoma (NHL), and 2 had multiple myeloma (MM). Patients were treated with {sup 60}Co gamma rays or 5-15MV photons. The fraction size ranged from 10-200 cGy and the total dose per treatment course from 30-1600 cGy. Significant pain relief was achieved for 74.8% of the RT courses given for splenic pain. At least 50% regression was attained for 77% of the RT courses given for SM. 36 patients died within 2 months due to the terminal nature of their disease. Of the RT courses applied for cytopenia, 73.6% achieved a significant improvement of hematological parameters and reduction of transfusion need. Notable hematologic toxicities were reported < EORTC/RTOG II . Conclusion: The present analysis documents the efficacy of RT. In addition, RT as a palliative treatment option for symptomatic SM should not be forgotten. (orig.)

  17. Application of transrectal ultrasonography in the diagnosis of gynecologic disease%经直肠超声在妇科疾病诊断中的应用

    Institute of Scientific and Technical Information of China (English)

    陶珍; 魏玲玲; 张红安


    Objective To discuss the using value of transrectal ultrasonography in the diagnosis of patients with gynecologic disease and nonsexual history. Methods The uterine, ovarian and pelvic of 83 patients were observed by transrectal and abdomen ultrasonography. Results The positive rate of detection results was 78.3%,in which the change of polycystic ovary accounting for 53% of the total cases. Conclusion The detection method and result of transrectal ultrasonography is basically same as transvaginal scan for female patients with nonsexual history;transrectal combined with abdomen ultrasonography can raise the accurately diagnostic rate and provide powerful imaging diagnostic basis for clinical diagnosis through combining with clinical detection results,especially for the diagnosis of polycystic ovarian syndrome.%  目的探讨经直肠超声在无性生活史等患者妇科疾病诊断中的应用价值。方法本组83例患者,采用经直肠超声,结合腹部超声补充检查,观察子宫、卵巢及盆腔情况。结果检出阳性率为78.3%,其中卵巢多囊改变占病例总数的53%。结论对于无性生活史等女性患者,经直肠超声的检查方法及结果,基本等同于经阴道超声检查;把直肠超声和腹部超声结合应用,以提高诊断率,结合临床检验结果,为临床医生的临床诊断,特别是对多囊卵巢综合征的诊断提供了有力的影像诊断依据。

  18. Non-progressive juvenile spinal muscular atrophy of the distal upper limb (Hirayama's disease: a clinical variant of the benign monomelic amyotrophy

    Directory of Open Access Journals (Sweden)



    Full Text Available Hirayama's disease (HD is frequently found in Asia, and is rarely referred among westerners. It affects young people with higher incidence in males. It is a focal distal amyotrophy with unilateral or asymmetric bilateral involvement of C7, C8 and T1 innervated muscles. HD appears sporadically and has a benign evolution with clinical stabilization in around one year. We report four young male patients with clinical and electrophysiological alterations described in HD, which were followed-up during 5 years. Electromyographic findings were indicative of lower motor neuron involvement. We analyzed cervical MRI aiming at understanding if a questionable spinal cord compression could be implicated in the pathogenesis, but no abnormality was verified. In view of its clinical, and EMG characteristics, HD is no more than a benign monomelic amyotrophy (BMA clinical variant, and not a specific disease. This eponym could be considered only for the distal upper limb variant (Hirayama's variant of the BMA.

  19. Non-progressive juvenile spinal muscular atrophy of the distal upper limb (Hirayama's disease): a clinical variant of the benign monomelic amyotrophy. (United States)

    Nascimento, O J; Freitas, M R


    Hirayama's disease (HD) is frequently found in Asia, and is rarely referred among westerners. It affects young people with higher incidence in males. It is a focal distal amyotrophy with unilateral or asymmetric bilateral involvement of C7, C8 and T1 innervated muscles. HD appears sporadically and has a benign evolution with clinical stabilization in around one year. We report four young male patients with clinical and electrophysiological alterations described in HD, which were followed-up during 5 years. Electromyographic findings were indicative of lower motor neuron involvement. We analyzed cervical MRI aiming at understanding if a questionable spinal cord compression could be implicated in the pathogenesis, but no abnormality was verified. In view of its clinical, and EMG characteristics, HD is no more than a benign monomelic amyotrophy (BMA) clinical variant, and not a specific disease. This eponym could be considered only for the distal upper limb variant (Hirayama's variant) of the BMA.

  20. A multicenter, randomized, double-blind comparison of roxatidine with ranitidine in the treatment of patients with uncomplicated benign gastric ulcer disease. The Multicenter Roxatidine Cooperative Study Group. (United States)

    Brandstätter, G; Marks, I N; Lanza, F; Kogut, D; Cobert, B; Savitsky, J P; Bender, W; Labs, R; Wurzer, H


    Roxatidine (150 mg, 312 patients) was compared with ranitidine (300 mg, 308 patients) in a randomized, double-blind, parallel-group, 6-week therapeutic study for the treatment of patients with uncomplicated, benign gastric ulcer disease. The study end points (verified by using endoscopy results) were fully healed ulcers at 4 or 6 weeks. The results of roxatidine therapy were comparable to those of ranitidine therapy: healing rates of 52% and 54% at week 4 and 77% and 76% at week 6 were recorded for roxatidine and ranitidine, respectively. The drugs produced comparable reductions in ulcer diameters and decreases in abdominal pain. Adverse events associated with both roxatidine (27%) and ranitidine (28%) were headache, diarrhea, and dizziness; rash was associated in 6 of 8 cases and in only 1 case with roxatidine. In this trial, roxatidine 150 mg once daily was as efficacious and safe as ranitidine 300 mg once daily for treatment of patients with uncomplicated, benign gastric ulcer disease.

  1. Diagnostic Ultrasound in Gynecologic Diagnosis


    Coates, C. F.


    Diagnostic ultrasound is helpful in the assessment of many common gynecological conditions from early teens to the late postmenopause. Female pelvic anatomy and pathology are readily imaged through a distended urinary bladder. In gynecologic cancer, examination of peritoneal cavity, kidneys and liver can suggest metastatic spread, which aids tumor staging.

  2. Non-progressive juvenile spinal muscular atrophy of the distal upper limb (Hirayama's disease): a clinical variant of the benign monomelic amyotrophy




    Hirayama's disease (HD) is frequently found in Asia, and is rarely referred among westerners. It affects young people with higher incidence in males. It is a focal distal amyotrophy with unilateral or asymmetric bilateral involvement of C7, C8 and T1 innervated muscles. HD appears sporadically and has a benign evolution with clinical stabilization in around one year. We report four young male patients with clinical and electrophysiological alterations described in HD, which were followed-up d...

  3. Rational application of tumor marker CA 125 in gynecological oncology

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    Đurđević Srđan


    Full Text Available Introduction CA 125 determination started in 1981, when Bast et al. discovered monoclonal antibody OC-125 belonging to immunoglobulin G class (IgG1 using Köhler and Milstein's technique of hybridization. CA 125 antigen is produced in amniotic cells of the 7 week-old embryo, while in adults it can be detected in epithelium of most organs which originate from Müller ducts. The upper level of referent values for CA 125 in serum is 35 U/mL and can be seen in about 99% of healthy people. Application of tumor marker CA 125 in gynecological oncology More than 83% of patients with epithelial ovarian carcinoma have elevated values of CA 125 higher than 35 U/mL at the moment of diagnosing the disease. In cases of ovarian carcinoma, preoperatively determined values of CA 125 in serum are correlated with the extent of the expansion of the disease , histological type of tumor and degree of differentiation of malignant cells. Elevated values up to 65 U/mL in serum can also be found in other malignant tumors (pancreas, breast, colon, bladder, lungs, liver and in different benign diseases. The level of serum CA 125 after the surgery can indicate regression or progression of ovarian carcinoma in more than 90% of the patients who had had elevated values of CA125 prior to the surgery. Postoperative levels of CA 125 >35 U/mL in patients with no residual tumor and values >65 U/mL in those with residual tumor implants represent a separate prognostic factor in further course of the disease. Conclusion The importance of continuous determination of CA 125 tumor marker has to be adjusted to each single case.

  4. Disseminated intravascular coagulation in obstetric and gynecologic disorders. (United States)

    Montagnana, Martina; Franchi, Massimo; Danese, Elisa; Gotsch, Francesca; Guidi, Gian Cesare


    Disseminated intravascular coagulation (DIC) is a syndrome characterized by a massive, widespread, and ongoing activation of the coagulation system, secondary to a variety of clinical conditions. Many obstetric complications, such as abruptio placentae, amniotic fluid embolism, endotoxin sepsis, retained dead fetus, post-hemorrhagic shock, hydatidiform mole, and gynecologic malignancies, might trigger DIC. In these gynecologic and obstetric settings, DIC is usually associated with high mortality and morbidity rates. No single laboratory test is sensitive or specific enough to diagnose DIC definitively, but it can be diagnosed by using a combination of multiple clinical and laboratory tests that reflect the pathophysiology of the syndrome. At present, the therapeutical approach to pregnancy- and gynecologic-related DIC comprises the specific and aggressive treatment of the underlying disease, eventually followed by a supportive blood product replacement therapy and restoration of physiological anticoagulant pathways. This article reviews the etiopathogenesis, clinical manifestations, laboratory diagnosis, and therapy of pregnancy- and gynecologic-related DIC.

  5. A new method for analyzing diagnostic delay in gynecological cancer

    DEFF Research Database (Denmark)

    Vandborg, Mai Partridge; Edwards, Kasper; Kragtrup, Jakob;


    OBJECTIVE: The aim of this article is to present a new methodology to illustrate, understand, and measure delay in health care. The method is inspired by process mapping tools as analytical framework and demonstrates its usefulness for studying diagnostic delay in gynecological cancer. MATERIALS...... AND METHODS: Six women with a diagnostic delay of 6 weeks or more before treatment of gynecological cancer at a specialized regional department (the Department of Gynecology and Obstetrics, Odense University Hospital, Denmark) were included in the study. Maps of existing processes were performed for each...... to responsibilities and was shown to recurrently influence and contribute to the delay in the diagnostic process. Some important contributors to diagnostic delay in gynecological cancer, such as lack of cancer suspicion, competing diseases, negative test results, inexpedient referral patterns, and referrals without...

  6. A New Method for Analyzing Diagnostic Delay in Gynecological Cancer

    DEFF Research Database (Denmark)

    Vandborg, Mai Partridge; Edwards, Kasper; Kragstrup, Jakob;


    OBJECTIVE: The aim of this article is to present a new methodology to illustrate, understand, and measure delay in health care. The method is inspired by process mapping tools as analytical framework and demonstrates its usefulness for studying diagnostic delay in gynecological cancer. MATERIALS...... AND METHODS: Six women with a diagnostic delay of 6 weeks or more before treatment of gynecological cancer at a specialized regional department (the Department of Gynecology and Obstetrics, Odense University Hospital, Denmark) were included in the study. Maps of existing processes were performed for each...... to responsibilities and was shown to recurrently influence and contribute to the delay in the diagnostic process. Some important contributors to diagnostic delay in gynecological cancer, such as lack of cancer suspicion, competing diseases, negative test results, inexpedient referral patterns, and referrals without...

  7. The impact of robotic surgery on gynecologic oncology. (United States)

    Nick, Alpa M; Ramirez, Pedro T


    The objective of this article was to review the published scientific literature pertaining to robotic surgery and its applications in gynecologic malignancies and to summarize the impact of robotic surgery on the field of gynecologic oncology. Summarizing data from different gynecologic disease-sites, robotic-assisted surgery is safe, feasible, and demonstrates equivalent histopathologic and oncologic outcomes. In general, benefits to robotic surgery include decreased blood loss, fewer perioperative complications and decreased length of hospital stay. Disadvantages include accessibility to robot surgical systems, decreased haptic sensation and fixed cost as well as cost of disposable equipment. As robotic surgery becomes readily available it will be imperative to develop standardized training modalities. Further research is needed to validate the role of robotic surgery in the treatment of gynecologic malignancies.

  8. Optimal carbon dioxide insufflation pressure during robot-assisted thyroidectomy in patients with various benign and malignant thyroid diseases

    Directory of Open Access Journals (Sweden)

    Kim Hoon


    Full Text Available Abstract Background Currently, data are not available concerning a safe insufflation pressure that provides a proper view of the surgical field without adverse metabolic and hemodynamic changes in humans undergoing the robot-assisted thyroidectomy bilateral axillo-breast approach (BABA using the da Vinci robotic surgical system. The purpose of this study was to determine the optimal carbon dioxide (CO2 insufflation pressure in patients with various benign and malignant thyroid diseases when using the da Vinci robotic surgical system. Methods A total of 32 patients underwent thyroid surgery at 6 (n = 15, 9 (n = 15, and 12 (n = 2 mmHg. The partial pressure of carbon dioxide (PaCO2, pH, cardiac output, heart rate, and mean arterial pressure were measured at baseline, 30 min and 1, 1.5, and 2 hours after CO2 insufflation, and 30 min after desufflation. Results CO2 insufflation of 12 mmHg caused severe facial subcutaneous emphysema, hypercarbia, and acidosis during robot-assisted thyroidectomy with BABA. The study was stopped before completion for the patients’ safety in accordance with the study protocol. Applying 6- or 9- mmHg of CO2 insufflation pressure caused increases in PaCO2 and decreases in arterial pH. However, vital signs were stable and pH and PaCO2 were within the physiologic range during the surgery in the 6- and 9-mmHg groups. Conclusions We propose that a CO2 insufflation pressure under 10 mmHg in robot-assisted thyroidectomy with BABA is the optimal insufflation pressure for patient safety.

  9. Benign Prostatic Hyperplasia


    Gil Ortega, Joan


    Benign prostatic hyperplasia (BPH) is a prevalent disease but its molecular mechanism remains unknown. Using human tissue samples from 16 patients diagnosed with BPH, we performed an ultrastructural study to clarify the mechanism and the role of glandular cells in this pathology. We have made a description of all the changes that suffers the prostatic epithelium. We have shown that the glandular architecture presents many non-physiological forms such as papillae and papillary fronds. Basal c...

  10. Investigation of change of serum immunosuppressive acidic protein levels in gynecological tumors

    Institute of Scientific and Technical Information of China (English)


    Objective: To study the clinical significance for measuring serum immunosuppressive acidic protein(IAP) levels to diagnose and follow up survey patients with the gynecological tumor.Methods: Serum IAP levels were determined by IAP-single radial immunodiffusion test in 235 patients with the gynecological tumor,including 38 cases of benign tumor of ovary,41 cases of malignant tumor of ovary,66 cases of hysteromyoma,34 carcinomas of uterine cervix, 16 endometrial carcinomas,27 cases of chemotherapy,13 cases of recurrence, and the control group was 50 cases health women.Results: Serum IAP level was 889.4±207.8mg/L in malignant ovary tumors,which was significantly higher than that of health women and benign tumors of ovary (P<0.01).In patients with carcinoma of uterine cervix and endometrial carcinoma, their IAP levels were 741.4±212.6mg/L and 763.3±209.4mg/L,which were higher than those of the health women and benign tumor of ovary(P<0.01).After chemotherapy, serum IAP levels of malignant tumor of ovary were decreased;in patients with recurrence of tumor of ovary,IAP levels increased compared with the health women(P<0.01).Incidence of the abnormal value was 100%.Conclusion:Measuring IAP level of the gynecological tumor may be an auxiliary index for monitoring gynecological tumor and identifying benign and malignant tumor.

  11. Analysis on the results of general investigation of gynecological diseases in 2 928 female college teachers%2928例高校女教工妇科疾病普查结果分析

    Institute of Scientific and Technical Information of China (English)



    Objective: To explore the prevalence and related factors of gynecological diseases in female college teachers, provide a scientific basis for reproductive health, prevention and health care of female college teachers. Methods; The data of general investigation of 2 928 person - limes in Yunnan university were analyzed retrospectively. Results-. The prevalence rates of gynecological diseases in younger group and elder group were 85. 7% and 61. 1% , respectively. In younger group, the incidence of breast diseases was the highest (43. 2% ) , followed by cervicitis (30.7% ) , the incidence of hysteromyoma ranked the fourth place, showing an obvious increasing trend. In elder group, the incidence of vaginitis was the highest (41, 5% ) , followed by breast diseases (18.6% ) . Conclusion; The reproductive health status of female college teachers is not optimistic, breast diseases and reproductive tract infection are the key points for prevention and treatment of gynecological diseases currently.%目的:探讨高校女教职工妇科疾病的发病情况及其相关因素,为女教工生殖健康及预防保健工作提供科学依据.方法:回顾性分析云南大学2928人次妇科病普查资料.结果:低龄组和高龄组患病率分别为85.7%和61.1%.低龄组以乳腺疾病居第1位(43.2%),宫颈炎为第2位(30.7%),子宫肌瘤居第4位且逐年上升趋势明显.高龄组以阴道炎居首位(41.5%),乳腺疾病居其次(18.6%).结论:高校女教职工的生殖健康状况不容乐观,乳腺疾病及生殖道感染是当前妇女病防治工作的重点.

  12. Doppler ultrasound in obstetrics and gynecology. 2. rev. and enl. ed.

    Energy Technology Data Exchange (ETDEWEB)

    Maulik, D. [Winthrop Univ. Hospital, Mineola, NY (United States). Dept. of Obstetrics and Gynecology; Zalud, I. (eds.) [Kapiolani Medical Center for Women and Children, Honolulu, HI (United States)


    The second edition of Doppler Ultrasound in Obstetrics and Gynecology has been expanded and comprehensively updated to present the current standards of practice in Doppler ultrasound and the most recent developments in the technology. Doppler Ultrasound in Obstetrics and Gynecology encompasses the full spectrum of clinical applications of Doppler ultrasound for the practicing obstetrician-gynecologist, including the latest advances in 3D and color Doppler and the newest techniques in 4D fetal echocardiography. Written by preeminent experts in the field, the book covers the basic and physical principles of Doppler ultrasound; the use of Doppler for fetal examination, including fetal cerebral circulation; Doppler echocardiography of the fetal heart; and the use of Doppler for postdated pregnancy and in cases of multiple gestation. Chapters on the use of Doppler for gynecologic investigation include ultrasound in ectopic pregnancy, for infertility, for benign disorders and for gynecologic malignancies. (orig.)

  13. Radioiodine therapy of benign thyroid diseases: Graves' disease - current aspects; Radioiodtherapie gutartiger Schilddruesenerkrankungen: Morbus Basedow - aktuelle Aspekte

    Energy Technology Data Exchange (ETDEWEB)

    Reinhardt, M.J. [Klinik und Poliklinik fuer Nuklearmedizin, Univ. Bonn (Germany)


    Radioiodine therapy is a reliable and cost-effective alternative to medical treatment of Graves' hyperthyroidism. Current recommendations favour a risk-adapted therapeutic procedure. Medical treatment is preferred in patients with a low risk of relapse which are characterised by the combination of female gender, age of onset above 40 years, thyroid volume below 40 ml and TSH-receptor antibodies below 10 U/l. Because of the poor remission rate with medical treatment in patients at less than 40 years of age, male gender, thyroid volume above 40 ml and TSH receptor antibodies above 10 U/l, it is suggested that definitive treatment with radioiodine or surgery should be considered soon after disease presentation. Analysis of cost-effectiveness clearly favour ablative radioiodine treatment. Ablative treatment is even more favourable in terms of early resumption of a normal life style of the hyperthyroid patient. Recent publications suggest further an adaptation of the tissue-absorbed dose to the pre-treatment thyroid volume using Marinelli's formula to achieve thyroid ablation with a single radioiodine treatment. (orig.)

  14. Application of nano-silver materials in gynecological diseases%纳米银材料在妇科疾病中的应用

    Institute of Scientific and Technical Information of China (English)

    王芳; 毛熙光


    目的:分析比较纳米银凝胶对不同程度、不同类型阴道炎及宫颈糜烂的治疗效果,及高频电波刀环切术结合纳米银与单纯高频电波刀在妇科疾病中的应用效果.方法:以 "纳米银;纳米银凝胶;阴道炎;宫颈炎"为检索词,索2006-01/2010-12相关文章.纳入与纳米银凝胶治疗阴道炎相关研究文献;排除重复研究或Meta分析类文章.以25篇文献为主进行分析.结果:纳米银凝胶是采用先进的纳米技术,单质银制成粒径约25 nm左右粒子,于其量子效应、小尺寸效应和极大的比表面积特性,于吸收,果较好.纳米银凝胶可在阴道和宫颈部位形成层保护膜,而杀灭致病微生物.可减少阴道排液及缩短阴道排液时间.结论:纳米银制剂具有安全、广谱、高效的抗菌、杀菌作用,于为患者接受,纳米银的生物安全性还有待进一步研究.%OBJECTIVE: To analyze the effects of nano-silver gel on vaginitis and cervical erosion at different levels and different types, and to compare the efficacy of LEEP combined with nano-silver and simple LEEP in treatment of gynecological diseases.METHODS: Relevant articles published in 2006-01/2010-12 were searched using "nano-silver; nano-silver gel; vaginitis;cervicitis" as keywords. Repetitive articles and Meta-analysis were excluded. Twenty-five articles were included.RESULTS: Nano-silver gel is prepared by advanced nanotechnology, about 25 nm in diameter, and characterized as quantum effect, small size effect and large su rface area, easy to be absorbed. Nano-silver gel can form a protective membrane in the vaginal and cervical parts, which can kill pathogenic microorganisms, reduce vaginal discharge and shorten the time of vaginal discharge.CONCLUSION: The nano-silver preparation is safe with broad-spectrum and highly effective antibacterial and sterilization, which is easy for patients. However, the biological safety of nano-silver has yet needed further studies.

  15. Pretransplant prediction of posttransplant survival for liver recipients with benign end-stage liver diseases: a nonlinear model.

    Directory of Open Access Journals (Sweden)

    Ming Zhang

    Full Text Available BACKGROUND: The scarcity of grafts available necessitates a system that considers expected posttransplant survival, in addition to pretransplant mortality as estimated by the MELD. So far, however, conventional linear techniques have failed to achieve sufficient accuracy in posttransplant outcome prediction. In this study, we aim to develop a pretransplant predictive model for liver recipients' survival with benign end-stage liver diseases (BESLD by a nonlinear method based on pretransplant characteristics, and compare its performance with a BESLD-specific prognostic model (MELD and a general-illness severity model (the sequential organ failure assessment score, or SOFA score. METHODOLOGY/PRINCIPAL FINDINGS: With retrospectively collected data on 360 recipients receiving deceased-donor transplantation for BESLD between February 1999 and August 2009 in the west China hospital of Sichuan university, we developed a multi-layer perceptron (MLP network to predict one-year and two-year survival probability after transplantation. The performances of the MLP, SOFA, and MELD were assessed by measuring both calibration ability and discriminative power, with Hosmer-Lemeshow test and receiver operating characteristic analysis, respectively. By the forward stepwise selection, donor age and BMI; serum concentration of HB, Crea, ALB, TB, ALT, INR, Na(+; presence of pretransplant diabetes; dialysis prior to transplantation, and microbiologically proven sepsis were identified to be the optimal input features. The MLP, employing 18 input neurons and 12 hidden neurons, yielded high predictive accuracy, with c-statistic of 0.91 (P<0.001 in one-year and 0.88 (P<0.001 in two-year prediction. The performances of SOFA and MELD were fairly poor in prognostic assessment, with c-statistics of 0.70 and 0.66, respectively, in one-year prediction, and 0.67 and 0.65 in two-year prediction. CONCLUSIONS/SIGNIFICANCE: The posttransplant prognosis is a multidimensional nonlinear

  16. Benign positional vertigo (United States)

    Vertigo - positional; Benign paroxysmal positional vertigo; BPPV: dizziness- positional ... Benign positional vertigo is also called benign paroxysmal positional vertigo (BPPV). It is caused by a problem in the inner ear. ...

  17. Robotic Surgery in Gynecologic Oncology

    Directory of Open Access Journals (Sweden)

    Robert DeBernardo


    Full Text Available Robotic surgery for the management of gynecologic cancers allows for minimally invasive surgical removal of cancer-bearing organs and tissues using sophisticated surgeon-manipulated, robotic surgical instrumentation. Early on, gynecologic oncologists recognized that minimally invasive surgery was associated with less surgical morbidity and that it shortened postoperative recovery. Now, robotic surgery represents an effective alternative to conventional laparotomy. Since its widespread adoption, minimally invasive surgery has become an option not only for the morbidly obese but for women with gynecologic malignancy where conventional laparotomy has been associated with significant morbidity. As such, this paper considers indications for robotic surgery, reflects on outcomes from initial robotic surgical outcomes data, reviews cost efficacy and implications in surgical training, and discusses new roles for robotic surgery in gynecologic cancer management.

  18. [Oncologic gynecology and the Internet]. (United States)

    Gizler, Robert; Bielanów, Tomasz; Kulikiewicz, Krzysztof


    The strategy of World Wide Web searching for medical sites was presented in this article. The "deep web" and "surface web" resources were searched. The 10 best sites connected with the gynecological oncology, according to authors' opinion, were presented.

  19. Hypermetabolic Calcified Lymph Nodes on 18Fludeoxyglucose-Positron Emission Tomography/Computed Tomography in a Case of Treated Ovarian Cancer Recurrence: Residual Disease or Benign Formation?

    Directory of Open Access Journals (Sweden)

    Alexandra Nikaki


    Full Text Available The contribution of positron emission tomography/computed tomography (PET/CT with 18F-fludeoxyglucose (FDG in evaluating ovarian cancer recurrence even after a prolonged disease-free interval, and in therapy response is well-described. Calcifications observed in CT, although usually attributed to benign conditions, may actually represent active disease. Such an example of calcified formations is psammoma bodies. We present a case of 56-y. o. patient with ovarian cancer relapse at the supraclavicular area 18 years after complete response and disease-free interval. The patient received chemotherapy and underwent 18F-FDG-PET/CT for the evaluation of treatment response. Both CT corrected and uncorrected PET images showed hypermetabolism in the massively calcified lymph nodes in the neck, mediastinum, axilla and abdomen, indicative of active residual disease

  20. 左炔诺孕酮宫内缓释系统在妇科疾病治疗中的作用%Effects of levonorgestrel-releasing intrauterine system in treating gynecological diseases

    Institute of Scientific and Technical Information of China (English)

    李广华; 何金良


    背景:左炔诺孕酮宫内缓释系统有很高的避孕可靠性,可对子宫内膜产生明显的抑制作用.目的:阐述左炔诺孕酮宫内缓释系统在妇科疾病治疗中的作用.方法:由第一作者检索CBM、PubMed数据库(、万方数据库(及google学术网1990/2010有关左炔诺孕酮宫内缓释系统治疗妇科疾病的文献,排除重复性研究.结果与结论:共保留17篇文献进行归纳总结.结果显示,左炔诺孕酮宫内缓释系统作为释放微量孕激素的宫内缓释系统,可安全、有效地应用于避孕,治疗月经过多、内异症、子宫腺肌病,以及激素替代治疗中对子宫内膜的保护等,对治疗子宫肌瘤引起的月经过多也有良好效果.提示左炔诺孕酮宫内缓释系统治疗妇科疾病效果显著,但还需要大样本、长期的临床研究加以验证.%BACKGROUND: Levonorgestrel-releasing intrauterine system is reliable in contraception by inhibiting endometrium.OBJECTIVE: To elucidate effects of levonorgestrel-releasing intrauterine system in treating gynecological diseases.METHODS: A computer-based online search of CBM, PubMed database (, Wanfang database (, and google search was performed for articles related to levonorgestrel-releasing intrauterine system in treating gynecological diseases, published between 1990 and 2010. Repetitive studies were excluded.RESULTS AND CONCLUSION: A total of 17 articles were included. As intrauterine progestogen-releasing system,levonorgestrel-releasing intrauterine system can be used as a safe and effective contraception method. In addition, it can treat menorrhagia, endometriosis, adenomyosis, protect endometrium, and ameliorate hysteromyoma-induced menorrhagia. Results revealed that levonorgestrel-releasing intrauterine system can effectively treat gynecological diseases. However, large

  1. The Combined Analysis of Clinical Care of Diabetes Patients with Gyneco-logical Diseases, Perioperative%糖尿病合并妇科疾病病人的围术期临床护理分析

    Institute of Scientific and Technical Information of China (English)



    目的:总结糖尿病合并妇科疾病患者的围术期护理措施。方法选取2015年1月—2016年1月在该院住院治疗的68例糖尿病并发妇科疾病患者进行探讨,根据护理方式的不同将其分为常规组和围手术组,常规组患者给予常规护理,围手术组患者在常规护理基础上实施围手术期全面护理,并比较两组患者抑郁(SDS)和焦虑(SAS)评分情况、住院天数以及对护理服务满意度。结果围手术组患者SDS和SAS评分、住院天数以及患者对护理服务满意度均显著优于常规组(P<0.05)。结论临床上对糖尿病并发妇科疾病患者实施围手术期全面护理服务不仅能有效改善患者不良心理情绪,还能缩短患者住院时间和提高患者对护理服务满意度。%Objective Summary gynecological diseases diabetes mellitus Perioperative nursing. Methods Select January 2015 ~ January 2016 in our hospital treated 68 cases of diabetes complicated gynecological diseases were discussed, ac-cording to the different ways of care will be divided into groups and regular group perioperative routine group were given routine care, Wai surgery patients embodiment perioperative comprehensive care in routine care, based on the two groups were compared and depression(SDS) and anxiety (SAS) score, the number of days of hospitalization and nursing service sat-isfaction. Results Perioperative patients SDS and SAS scores, length of hospital stay and patient satisfaction with care were significantly superior to the conventional group(P<0.05). Conclusion Clinically, patients with diabetes mellitus gynecological diseases embodiment comprehensive perioperative care can not only improve mood in patients with adverse psychological, but also shorten the length of hospital stay, and increased patient satisfaction with nursing services.


    Institute of Scientific and Technical Information of China (English)



    [目的]了解贵阳市区及周边乡镇已婚育龄妇女乳腺和妇科疾病的病种、患病率及其影响因素,为今后开展妇女保健工作提供依据.[方法]对6125例已婚育龄妇女进行常规乳腺和妇科疾病检查,并根据普查结果对各年龄段已婚育龄妇女妇科疾病的患病人数以及患病率进行对比分析.[结果]常见妇科疾病患病人数1964例,患病率32.07%,其中宫颈糜烂患病人数最多,达608例,其次是阴道炎、子宫肌瘤、盆腔炎、附件囊肿;各年龄阶段妇科疾病患病率组间差异具有统计学意义(P﹤0.01),31~40岁患病率最高,约为10.36%;参加乳腺疾病普查人数5193例,常见乳腺疾病中乳腺增生患病人数最高,约为860例,患病率为16.6%.[结论]加强育龄妇女保健工作的宣传力度,提高妇女的自我保护意识;组织专业医疗队伍对育龄妇女进行定期普查,并制定相应的预防和治疗措施,减低发病率,提高治愈率.%[Objective] To investigate the disease categories, prevalence and impact factors of breast and gynecological diseases of manied childbearing age women in Guiyang city and its surrounding towns to provide the basis for canying out the work of women's health in the future. [Methods] 6 125 cases of married childbearing age women were given routine breast and gynecological disease inspections. Then compared the number of patients and the prevalence of women in different age groups.[ Results] The number of patients with common gynecological disease was 1 964 and the prevalence was 32.07%. The number of patients with cervical erosion prevalence accounted for the largest portion. reaching 608, followed by vaginitis. uterine. fibroids. pelvic inflammatory disease, and accessories cyst; There was a statistically significant difference on the prevalence of patients with gynecological diseases in different age groups (P < 0.01) , the highest one was among 31-40 years old, which was about 10.36%; The

  3. Evaluation of thyroid antibodies and benign disease prevalence among young adults exposed to 131I more than 25 years after the accident at the Chernobyl Nuclear Power Plant

    Directory of Open Access Journals (Sweden)

    Yuko Kimura


    Full Text Available Background. The Chernobyl Nuclear Power Plant (CNPP accident exposed a large number of inhabitants to internal 131I radiation. The associations between internal 131I exposure and thyroid autoimmunity and benign thyroid diseases remain controversial in the population living in the contaminated area around the CNNP. In this study, we evaluate the association of 131I with benign thyroid diseases. Methods. We compared the prevalence of Anti-Thyroid Autoantibodies (ATAs, thyroid function, and prevalence of thyroid ultrasound finding outcomes in 300 residents of the contaminated area of Ukraine who were 0–5 years of age at the time of the CNPP accident (group 1 and 300 sex-matched residents who were born after the accident (group 2. Results. We did not find any differences of the prevalence of Antithyroglobulin Antibodies (TGAb positive, Antithyroid Peroxidase Antibodies (TPOAb positive, and TGAb and/or TPOAb positive between the study groups. (11.7% vs 10.3%; p = 0.602, 17.3% vs 13.0%; p = 0.136, 21.0% vs 17.3%; p = 0.254, respectively; after adjusting for age and sex, the prevalence was not associated with the 131I exposure status in the study groups. The prevalence of subclinical and overt hypothyroidism cases was not significantly different (p = 0.093 and p = 0.320 in the two groups, nor was the prevalence of goiter (p = 0.482. On the other hand, the prevalence of nodules was significantly higher in group 1 (p = 0.003, though not significantly so after adjustment for age and sex. Discussion. Working 26–27 years after the CNNP accident, we found no increased prevalence of ATAs or benign thyroid diseases in young adults exposed to 131I fallout during early childhood in the contaminated area of Ukraine. Long-term follow-up is needed to clarify the effects of radiation exposure on autoimmunity reaction in the thyroid.

  4. Genetics of Breast and Gynecologic Cancers (PDQ®)—Health Professional Version (United States)

    Expert-reviewed information summary about the genetics of breast and gynecologic cancers, including information about specific genes and family cancer syndromes. The summary also contains information about interventions that may influence the risk of developing breast and gynecologic cancers in individuals who may be genetically susceptible to these diseases. Psychosocial issues associated with genetic testing are also discussed.

  5. The Lymphedema and Gynecologic Cancer (LEG) Study: Incidence, Risk Factors, and | Division of Cancer Prevention (United States)

    DESCRIPTION (provided by applicant): The proposed study, "Lymphedema and Gynecologic cancer (LEG): Incidence, Risk Factors and Impact", will innovatively utilize the cooperative group setting of the GOG (Gynecologic Oncology Group) to prospectively study 1300 women newly diagnosed with cervical, endometrial, or vulvar cancer to determine the incidence and impact of lower extremity lymphedema following surgical treatment of these diseases. |

  6. Laser treatment in gynecology (United States)

    de Riese, Cornelia


    This presentation is designed as a brief overview of laser use in gynecology, for non-medical researchers involved in development of new laser techniques. The literature of the past decade is reviewed. Differences in penetration, absorption, and suitable delivery media for the beams dictate clinical application. The use of CO2 laser in the treatment of uterine cervical intraepithelial lesions is well established and indications as well as techniques have not changed over 30 years. The Cochrane Systematic Review from 2000 suggests no obviously superior technique. CO2 laser ablation of the vagina is also established as a safe treatment modality for VAIN. CO2 laser permits treatment of lesions with excellent cosmetic and functional results. The treatment of heavy menstrual bleeding by destruction of the endometrial lining using various techniques has been the subject of a 2002 Cochran Database Review. Among the compared treatment modalities are newer and modified laser techniques. Conclusion by reviewers is that outcomes and complication profiles of newer techniques compare favorably with the gold standard of endometrial resection. The ELITT diode laser system is one of the new successful additions. CO2 laser is also the dominant laser type used with laparoscopy for ablation of endometriotic implants. Myoma coagulation or myolysis with Nd:Yag laser through the laparoscope or hysteroscope is a conservative treatment option. Even MRI guided percutaneous approaches have been described. No long-term data are available.

  7. The loneliness level of patients with gynecological cancer. (United States)

    Sevil, U; Ertem, G; Kavlak, O; Coban, A


    The purpose of this descriptive study was to determine the loneliness levels and the variables that have an effect on the loneliness of women with a gynecological cancer diagnosis. The main questions that the study addressed were as follows: (1) What is the loneliness level of patients with gynecological cancer? and (2) What kind of relationships are there between general demographic characteristics of patients with gynecological cancer and their loneliness? This descriptive study was conducted at Ege University, Faculty of Medicine, Application and Investigation Hospital, Maternity and Women Diseases Gynecology Clinic, from July to December 2002. Maternity and Women Diseases Clinic Oncology Service treated 161 patients during this time period. While all patients hospitalized between the specified dates constituted the universe of the investigation; the actual sample was 94 patients. As data collection tools, a questionnaire form, which aimed at identifying sociodemographic characteristics of patients and the features related to their diseases relevant to the literature and the UCLA-loneliness scale were used. The general loneliness mean score of women with gynecological cancer was 35.85 +/- 9.302. Women's mean scores of loneliness were affected by whether psychologic support was needed, genital organ diseases were treated, or a family member had a gynecological operation, and by the income situation. The disease of cancer, which creates the most fear and anxiety in the community, has adverse psychologic effects on both the patient and the family. In societies where men dominate, as is the case in our society, women's place in the society has been reduced to their reproductive capacity, and thus, the health of their genital organs is very important.

  8. Analyze the Eighth Item of Pulse Syndrome Complex and Treatment of Miscellaneous Gynecological Diseases from Jinkui Yaolve%《金匮要略·妇人杂病脉证并治》第八条浅析

    Institute of Scientific and Technical Information of China (English)

    杨娇娇; 徐光星


    [目的]探析《金匮要略》“妇人杂病脉证并治”篇第八条原文旨意。[方法]通过对《金匮要略》“妇人杂病脉证并治”篇的仔细研读、思考,并参阅历代医家对第八条条文的注解,围绕妇人杂病的因机证治对本条原文进行分析、阐释。[结果]《金匮要略》“妇人杂病脉证并治”篇第八条为妇女诸病纲领,“因虚、积冷、结气”六字为其病因机要,而“因虚”居六字之首;第2句“久成肺痈”之“痈”字当是“痿”字之误;病证“凝坚在上”、“在中盘结”,男女均可出现,非女子独有,“肺痿”、“寒疝”、“胁腹痛”、“脐下关元痛”、“劳热”、“肌肤甲错”等证在《金匮要略》其它篇章各有专述及记载;病证“在下”则专属妇人杂病,以经带诸病为主,证属虚寒夹瘀(郁)型。[结论]《金匮要略》妇人杂病脉证并治,开后世辨治妇人杂病之先河,随人类社会之发展,时代之更替,仲景对妇科杂病的认识至今仍具借鉴意义。%Objective]To explore and analyze its original implication of the eighth article in Chapter 22 from Jinkui Yaolve. [Methods]Through learning the Jinkui Yaolve closely and referring to the explanations of masters of generations,base on the original text to analyze and elaborate the etiology, pathogenesis, syndromes and therapeutic principles with regard to miscellaneous gynecological diseases.[Results] The eighth item is the general program of miscellaneous gynecological diseases,its principal pathogenic factors include deficiency, stale chills and stagnation of Qi.Moreover,the deficiency plays a leading role in the pathogenesis.Through exploring deeply,I hold that the pulmonary abscess is actually the pulmonary asthenia in the second sentence.When the pathogenic factors attack the body,the triple energizers manifest different symptoms and signs.There is no difference between male

  9. 张家口市2012年城镇女职工妇女病专项筛查情况分析%Analysis of gynecologic diseases screening results of in-service female workers in Zhangjiakou in 2012

    Institute of Scientific and Technical Information of China (English)

    陈立霞; 王艳; 李海荣; 宋志秀; 姜娟


    Objectives:To investigate the status and trends as well as prevalence rate of gynecological dis-ease,so as to provide a scientific basis for the development of interventions to gynecological diseases prevention and control and improve female health in Zhangjiakou.Methods:The special screening was implemented among 28,925 female workers,including routine gynecological,breast palpation,breast ultrasound,pelvic ultrasound,liquid -based cytology test (TCT examination the cervix).Results:In the 28,925 cases,20,189 (69.79%)got such dis-eases,the first four of which were breast disease (34.52%),cervical disease (24.24%),vulvovaginitis (7.60%)and uterine fibroids (3.76%).Conclusion:To carry out a special screening of gynecological diseases is a focus of female healthcare in the future.Health education should be carried out actively,to enhance female health knowledge popularization and improve the awareness of female self-care;interventions according female health-related factors shall be conducted to improve their health and quality of life.%目的:了解张家口地区妇女病发病状况和变化趋势,探讨妇女病的患病率,为制定妇女病防治工作的干预措施提供科学依据,以提高张家口地区妇女健康水平。方法:对28925例在职女职工进行专项筛查,主要包括妇科常规、乳腺触诊、乳腺彩超、盆腔彩超、液基薄层细胞检测(宫颈TCT检查)。结果:28925例中,患病20189(69.79%),前4位分别是乳腺疾病34.52%、宫颈疾病24.24%、外阴阴道炎7.60%和子宫肌瘤3.76%。结论:开展妇科病专项筛查是今后妇女保健工作的重点,应积极开展健康教育,加强妇女保健知识科普宣传,提高广大妇女的自我保健意识,针对影响妇女健康的相关因素采取干预措施,提高妇女健康水平和生活质量。

  10. 厦门市2004~2008年女职工妇科病普查情况分析%Analysis on the general investigation situation of gynecological diseases among the female staff in Xiamen city from 2004 to 2008

    Institute of Scientific and Technical Information of China (English)

    吴冬梅; 柯珣瑜


    目的:探讨厦门市2004~2008年女职工妇科常见疾病发病率及疾病谱的变化,采取相应对策和干预措施,降低妇科病的发病率,为妇女保健提供依据.方法:对2004~2008年厦门市100多家行政、企事业单位中20 ~65岁的54 581例女职工进行妇科病普查,按照厦门市统一制定的妇科普查卡片内容,对普查对象逐个询问病史填写卡片,常规进行妇科检查及辅助检查.结果:2004~2008年妇科病的患病率呈逐年上升趋势(P<0.005).除宫颈癌和乳腺癌以外,宫颈炎、阴道炎、子宫肌瘤、乳腺增生的患病率呈上升趋势(P <0.005).结论:厦门市女职工妇科病总体患病率呈上升趋势,几种常见的妇科病患病率也呈上升趋势,说明定期进行妇科病普查普治是必要的,同时应加强健康教育,提高女职工的自身保健知识,养成健康的生活方式,努力降低妇科常见疾病发病率,提高妇女健康水平.%Objective: To explore the incidences of common gynecological diseases among the female staff and the change of spectrum of disease in Xiamen city from 2004 to 2008, adopt corresponding countermeasures and interventional measures, reduce the incidences of gynecological diseases, provide a basis for women's health care. Methods; A total of 54 581 female staff aged 20 -65 years old from more than 100 administrative units, enterprises and institutions in Xiamen city from 2004 to 2008 underwent general investigation of gynecological diseases, the contents of general investigation cards of gynecological diseases were determined uniformly, then the medical history of the research objects were inquired one by one, the cards were finished, gynecological examination and assisted examination were performed routinely. Results: The incidences of gynecological diseases from 2004 to 2008 showed an increasing trend year by year ( P < 0.005) . The incidences of cervical inflammation, vaginitis, hysteromyoma, and breast

  11. Aromatase inhibitors in gynecologic cancers. (United States)

    Krasner, Carolyn


    The female genital tract is hormonally responsive, and consequently some tumors, which arise within in it, may be treated at least in part, with hormonal manipulation. The range of responses in clinical trials and case reports will be reviewed. Many of these diseases are too rare for clinical trial testing, and in some cases evidence is anecdotal at best. Recurrences of ovarian cancer have been treated with tamoxifen and megesterol acetate with variable response rates from 0 to 56%. The favorable toxicity profile of aromatase inhibitors led to trials of these agents for the treatment of relapsed epithelial ovarian cancer. These agents have proved tolerable with minor response rates but a significant disease stabilization rate, which may be prolonged in a minority of cases. It is unclear if these responses may be predicted by estrogen receptor expression or aromatase expression. Anastrazole has also been tried in combination with an EGFR receptor-inhibitor, again showing minor responses but possibly an increase in TTT in some patients. Granulosa cell tumors of the ovary are rare, hormonally sensitive tumors, with reported responses to a variety of hormonal manipulations, including aromatase inhibition. In addition, combined endocrine blockade, including aromatase inhibition, has been tried with reports of success. Endometrial cancers, particularly type I lesions, are often treated with hormonal manipulation, most commonly with progestins, but also with antiestrogens such as tamoxifen. A trial of aromatase inhibition in the treatment of recurrent endometrial cancer showed minimal responses. Endometrial stromal sarcoma, an uncommon uterine malignancy, has shown response to hormonal treatments, with multiple case reports of efficacy of aromatase inhibition. Despite the rarity of some of these tumor types, rare tumor study groups, such as within the Gynecologic Oncology Group, should make an effort to prospectively define the utility of these treatments.

  12. Application of laser in obstetrics and gynecology (United States)

    Ding, Ai-Hua


    Mainman developed the first ruby laser in 1960 and after 13 Kaplan successfully reported the use of CO2 laser in the treatment of cervicitis. Soon after, Chinese gynecologists started to use the laser for diagnosis and therapy. It had been proved that more than 30 kinds of gynecological diseases could be treated effectively by laser. The remarkable laser treatment technique partially replaced with conventional methods used in that century. However, the application of laser had shown a broad prospect along with its further investigation.

  13. Benign anal lesions, inflammatory bowel disease and risk for high-risk human papillomavirus-positive and -negative anal carcinoma.


    Frisch, M; Glimelius, B; van den Brule, A. J.; Wohlfahrt, J; Meijer, C. J.; Walboomers, J M; Adami, H. O.; Melbye, M.


    A central role in anal carcinogenesis of high-risk types of human papillomaviruses (hrHPV) was recently established, but the possible role of benign anal lesions has not been addressed in hrHPV-positive and -negative anal cancers. As part of a population-based case-control study in Denmark and Sweden, we interviewed 417 case patients (93 men and 324 women) diagnosed during the period 1991-94 with invasive or in situ anal cancer, 534 patients with adenocarcinoma of the rectum and 554 populatio...

  14. Benign cephalic histiocytosis. (United States)

    Gianotti, F; Caputo, R; Ermacora, E; Gianni, E


    Benign cephalic histiocytosis is a self-healing non-X, nonlipid cutaneous histiocytosis of children, characterized by a papular eruption on the head. Mucous membranes and viscera are always spared. In the 13 cases reported herein, the children were otherwise in good general health. The disease appeared during the first three years of life, and spontaneous regression was complete by the age of nine years in the four cases healed to date. The histiocytic infiltrate was localized in the upper and middle dermis and contained no lipids at any stage of evolution. All the histiocytes contained coated vesicles, and 5% to 30% also contained comma-shaped bodies in their cytoplasm.

  15. The role of selenium, vitamin C, and zinc in benign thyroid diseases and of selenium in malignant thyroid diseases: Low selenium levels are found in subacute and silent thyroiditis and in papillary and follicular carcinoma

    Directory of Open Access Journals (Sweden)

    Starzinger Matthias


    Full Text Available Abstract Background Thyroid physiology is closely related to oxidative changes. The aim of this controlled study was to evaluate the levels of nutritional anti-oxidants such as vitamin C, zinc (Zn and selenium (Se, and to investigate any association of them with parameters of thyroid function and pathology including benign and malignant thyroid diseases. Methods This controlled evaluation of Se included a total of 1401 subjects (1186 adults and 215 children distributed as follows: control group (n = 687, benign thyroid disease (85 children and 465 adults; malignant thyroid disease (2 children and 79 adults. Clinical evaluation of patients with benign thyroid disease included sonography, scintigraphy, as well as the determination of fT3, fT4, TSH, thyroid antibodies levels, Se, Zn, and vitamin C. Besides the routine oncological parameters (TG, TSH, fT4, ultrasound Se was also determined in the cases of malignant disease. The local control groups for the evaluation of Se levels were taken from a general practice (WOMED as well as from healthy active athletes. Blood samples were collected between 8:00 and 10:30 a.m. All patients lived in Innsbruck. Statistical analysis was done using SPSS 14.0. The Ho stated that there should be no differences in the levels of antioxidants between controls and thyroid disease patients. Results Among the thyroid disease patients neither vitamin C, nor Zn nor Se correlated with any of the following parameters: age, sex, BMI, body weight, thyroid scintigraphy, ultrasound pattern, thyroid function, or thyroid antibodies. The proportion of patients with benign thyroid diseases having analyte concentrations below external reference cut off levels were 8.7% of cases for vitamin C; 7.8% for Zn, and 20.3% for Se. Low Se levels in the control group were found in 12%. Se levels were significantly decreased in cases of sub-acute and silent thyroiditis (66.4 ± 23.1 μg/l and 59.3 ± 20.1 μg/l, respectively as well as in

  16. CCCT - NCTN Steering Committees - Gynecologic Cancers (United States)

    The Gynecologic Cancers Steering Committee evaluates and prioritizes concepts for phase 2 and 3 clinical trials in adult gynecologic cancers. The GCSC is also intent on fostering collaboration with international groups and institutions conducting trials.

  17. Robotic Surgery in Gynecology: An Updated Systematic Review

    Directory of Open Access Journals (Sweden)

    Lori Weinberg


    Full Text Available The introduction of da Vinci Robotic Surgery to the field of Gynecology has resulted in large changes in surgical management. The robotic platform allows less experienced laparoscopic surgeons to perform more complex procedures. In general gynecology and reproductive gynecology, the robot is being increasingly used for procedures such as hysterectomies, myomectomies, adnexal surgery, and tubal anastomosis. Among urogynecology the robot is being utilized for sacrocolopexies. In the field of gynecologic oncology, the robot is being increasingly used for hysterectomies and lymphadenectomies in oncologic diseases. Despite the rapid and widespread adoption of robotic surgery in gynecology, there are no randomized trials comparing its efficacy and safety to other traditional surgical approaches. Our aim is to update previously published reviews with a focus on only comparative observational studies. We determined that, with the right amount of training and skill, along with appropriate patient selection, robotic surgery can be highly advantageous. Patients will likely have less blood loss, less post-operative pain, faster recoveries, and fewer complications compared to open surgery and potentially even laparoscopy. However, until larger, well-designed observational studies or randomized control trials are completed which report long-term outcomes, we cannot definitively state the superiority of robotic surgery over other surgical methods.

  18. Combination of ultrasound-guided percutaneous microwave ablation and radioiodine therapy in benign thyroid disease. A 3-month follow-up study

    Energy Technology Data Exchange (ETDEWEB)

    Korkusuz, H.; Happel, C.; Koch, D.A.; Gruenwald, F. [Frankfurt University Hospital (Germany). Dept. of Nuclear Medicine


    Pilot studies of combined therapies treating benign nodular goiters reported promising results. The aim of this study was to investigate the effectiveness of combined microwave ablation (MWA) and radioiodine therapy (RIT) with a special focus on thyroid function at the 3-month follow-up. 15 patients (median age: 55 years) with a large goiter and benign thyroid nodules or Graves' disease were treated with the combined therapy. Serum levels of triiodothyronine (T3), thyroxine (T4), thyrotropin (TSH), thyroglobuline (Tg) and, additionally, antibody levels against thyroglobulin (TgAb), thyrotropin receptors (TRAb) and thyroid peroxidase (TPOAb) were measured at enrollment, post MWA and at the 3-month follow-up (3MFU). Furthermore, the goiter volume, I-131 dose and hospitalization time were analyzed to evaluate effectiveness. MWA was operated under local anesthesia with a system working in a wavelength field of 902 to 928 MHz. TSH, T4, T3 and Tg did not change at 3MFU, except for in two patients in whom the initial TSH levels improved to normal thyroid functioning levels at follow-up. One of the patients developed a high TRAb-level that receded back into the normal range. At 3MFU, the combined therapy showed a mean thyroid volume reduction of 26.4 ml ± 7.9 ml (30.5 % ± 4.6 % (p < 0.05)). By utilizing the combined therapy, administered activity could be reduced by 26.6 % ± 4.8 % (p < 0.05) and hospitalization time by 30.9 % ± 19.9 % (p < 0.05). The data confirmed the effectiveness of the combination of MWA with RIT. The combined therapy is an innovative and conservative approach and could become a safe alternative to surgery for the treatment of very large benign nodular goiters. Due to the short follow-up and the limited number of patients, further studies will be necessary.

  19. Application of the donkey-hide gelatin in gynecology diseases in the Qian Jin Fang%阿胶在《千金方》妇科疾病中的应用

    Institute of Scientific and Technical Information of China (English)

    王静; 王晓明; 田思胜


    Woman has the special physiological function, which determines different cure methods when they are ill. Catamenia, pregnancy, childbearing and lactation are all related with blood. The donkey-hide gelatin is regularly used in clinical practice with its function of regulating blood. It is a common gynecological herb in treatment of gynecological diseases, for the good effect of nourishing blood for moistening dryness and nourishing blood for preventing miscarriage. Because it is the sentient flesh thing, the donkey-hide gelatin can nourish Qi and blood, consolidate Chong vessel well in postpartum. This paper discusses the usage of donkey-hide gelatin in Qian Jin Fang which was written by SUN Si-miao for providing reference and inspiration in modern clinical and medical research.%妇人特殊的生理现象,决定了其治疗时立方有别.妇女经、孕、产、乳的生理活动均以血为用,而阿胶是治疗或调养时常用理血之药,同时为妇科疾病常用药,是养血润燥佳品,是养血安胎圣药,是产后调养气血,血肉有情之物,为养血固冲之上品.文章通过对阿胶在《千金方》中的运用浅析,以期阿胶在现代临床应用和医学研究中提供借鉴和启迪.

  20. [Synchronous tumors of the female genital tract: triple malignant and one benign tumor]. (United States)

    Dudnyikova, Anna; Vereczkey, Ildikó; Pete, Imre


    Synchronous tumors of the female genital tract are rare, accounting for 0.7-1.8% of all cases. Double synchronous tumors are most often mentioned in the literature. Reviewing the English literature on this topic, we have found only one case report of a triple synchronous tumor. The 55-year-old patient mentioned in our case has had advanced diabetes mellitus, and has been treated with corticosteroid therapy for a long time because of chronic obstructive pulmonary disease (COPD). She was examined because of her vulvar tumor. During the diagnostic procedure, cervical and endometrial malignant tumors and a benign ovarian cyst have also been found. This event brings to our attention the fact that we should be prepared to manage synchronous even triple malignant gynecological tumors.

  1. Multi-sequential surface plasmon resonance analysis of haptoglobin-lectin complex in sera of patients with malignant and benign prostate diseases. (United States)

    Kazuno, Saiko; Fujimura, Tsutomu; Arai, Takahiro; Ueno, Takashi; Nagao, Keiji; Fujime, Makoto; Murayama, Kimie


    Screening for prostate cancer remains unsatisfactory. Recent studies have examined the cancer diagnostic/prognostic values of various acute phase proteins, such as haptoglobin. We describe here a novel method of surface plasmon resonance (SPR) based on multi-sequential analysis with SNA-1, AAL, and PHA-L(4) lectin, to estimate the glycosylation status of haptoglobin in sera of patients with prostate cancer (n=15), benign prostate disease (BPD) including benign prostatic hypertrophy (n=20), and normal subjects (n=11). The SPR-based analysis involves the use of anti-haptoglobin as ligand and dilution of the analyte to 1400-fold and filtration, followed by detection of the sugar chain by lectin solution. The normalized RU of lectin to haptoglobin represents the binding amount of lectin divided by that of haptoglobin. The normalized RU by SNA-1 of the prostate cancer group was significantly higher than those of the control and BPD group. SNA-1 detected NeuAcα2,6 in a biantennary sugar chain, whose content was the highest among the major glycoproteins in serum. Serum samples diluted about 7000-fold were subjected to microanalysis at 10 ng/μl and 10 μl/min for 4 min. The combination of SNA-1 and haptoglobin by SPR multi-sequential analysis offered the most accurate diagnosis of prostate cancer without any modification of serum glycoproteins.

  2. The optimal organization of gynecologic oncology services: a systematic review (United States)

    Fung-Kee-Fung, M.; Kennedy, E.B.; Biagi, J.; Colgan, T.; D’Souza, D.; Elit, L.M.; Hunter, A.; Irish, J.; McLeod, R.; Rosen, B.


    Background A system-level organizational guideline for gynecologic oncology was identified by a provincial cancer agency as a key priority based on input from stakeholders, data showing more limited availability of multidisciplinary or specialist care in lower-volume than in higher-volume hospitals in the relevant jurisdiction, and variable rates of staging for ovarian and endometrial cancer patients. Methods A systematic review assessed the relationship of the organization of gynecologic oncology services with patient survival and surgical outcomes. The electronic databases medline and embase (ovid: 1996 through 9 January 2015) were searched using terms related to gynecologic malignancies combined with organization of services, patterns of care, and various facility and physician characteristics. Outcomes of interest included overall or disease-specific survival, short-term survival, adequate staging, and degree of cytoreduction or optimal cytoreduction (or both) for ovarian cancer patients by hospital or physician type, and rate of discrepancy in initial diagnoses and intraoperative consultation between non-specialist pathologists and gyne-oncology–specialist pathologists. Results One systematic review and sixteen additional primary studies met the inclusion criteria. The evidence base as a whole was judged to be of lower quality; however, a trend toward improved outcomes with centralization of gynecologic oncology was found, particularly with respect to the gynecologic oncology care of patients with advanced-stage ovarian cancer. Conclusions Improvements in outcomes with centralization of gynecologic oncology services can be attributed to a number of factors, including access to specialist care and multidisciplinary team management. Findings of this systematic review should be used with caution because of the limitations of the evidence base; however, an expert consensus process made it possible to create recommendations for implementation. PMID:26300679


    Institute of Scientific and Technical Information of China (English)



    [ Objective ] To assess transabdominal and transvaginal ultrasonography in the diagnosis of emergency of ob stetric and gynecological diseases. [Methods] From June 2007 to October 2010, transabdonminal and transvaginal ultrasonog raphy examination of 148 cases of acute abdomen in obstetrics and aynecology patients in our hospital were retrospectively, and the clinic data were collected to analyze the imaging features and ultrasonic diagnosis of acute abdomen in obstetrics and gyne cology. [ Results] The group of 148 cases were examined by abdominal and ultrasonography. 51 patients were ruptured ectopic pregnancy and abortion, 20 patients were avarian corpus luteum cystrupture , 5 patients were ovarian chocolate cyst rupture, 16 patients were ovarian torsion, 35 patients were acute pelvic inflammatory disease, 12 patients were various types of abortion and 9 patients were placental abruption. There were 148 cases showed coincidence in ultrasonography and pathological diagnasis, the rate of coincidence was 97.30%. [ Conclusion] Transabdominal and transvaginal ultrasonography can find pathological changes of obstetic and gynecological diseases accurately and rapidly, and this method has aspects of simple, accuracy and painless. This method could be preferred method in diagnosis of acute abdomen of obstetics and gynecology, and provide solid reference in determining treatment method.%[目的]探讨经腹部及阴道超声联合应用在妇产科急腹症中的诊断价值. [方法]对本院自2007年6月~2010年10月经腹部及阴道超声联合检查的148例妇产科急腹症患者的临床资料进行回顾性分析.分析其声像图特征及超声诊断对妇产科急腹症的诊断价值. [结果]本组148例患者经腹部及阴道超声联合检查,其中异位妊娠流产破裂患者51例,卵巢黄体囊肿破裂患者20例,卵巢巧克力囊肿破裂患者5例,卵巢蒂扭转患者16例,急性盆腔炎性疾病患者35例,各种类型流产患者12

  4. Lipomatosis simétrica benigna de la lengua en la enfermedad de Madelung Benign symmetric lipomatosis of the tongue in Madelung’s disease

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    A. López Ceres


    Full Text Available La enfermedad de Madelung, o lipomatosis simétrica benigna es una enfermedad rara caracterizada por acúmulos grasos no encapsulados localizados de forma simétrica alrededor de cuello y hombros. Esta enfermedad, afecta predominantemente a hombres en edades comprendidas entre los 30 y 60 años, con una relación hombre:mujer de 15:1. Existe una gran relación con el abuso del alcohol. Las personas no alcohólicas y las mujeres también pueden verse afectadas, aunque de forma más rara. Presentamos el caso de una mujer diagnosticada de Enfermedad de Madelung refiriendo engrosamiento progresivo de la lengua. Presentaba dificultad para tragar, disartria y disnea con el decúbito.Madelung´s disease, or benign symmetric lipomatosis, is an uncommon disease characterized by non-encapsulated accumulations of fat in a symmetric manner around the neck and shoulders. This uncommon disease predominantly affects men between the ages of 30 and 60 and it has a 15:1 ratio. There is a strong correlation with alcohol abuse. Nonalcoholics and women can also be affected although this is rare. We report the case of a woman diagnosed with Madelung’s disease, who described a gradual swelling of the tongue. She had difficulty swallowing, dysarthria and dyspnea while sleeping.

  5. Professor LIAN Yu-lin's Experience in Treating Gynecological Disorders by Acupuncture

    Institute of Scientific and Technical Information of China (English)



    @@ Professor LIAN Yu-lin, a chief doctor in the acupuncture department of the first affiliated hospital of Tianjin College of Traditional Chinese Medicine, has been engaged himself in Chinese medicine for over 30 years with perfect medical skills and rich experience in the treatment of cerebrovascular diseases and cervical and lumbar diseases, especially in the treatment of gynecological disorders by acupuncture. I follow professor Lian as an intern and have learnt some skillful techniques in the treatment of gynecological disorders by acupuncture.

  6. Vacuum-assisted breast biopsy: A comparison of 11-gauge and 8-gauge needles in benign breast disease

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    Kraemer Bernhard


    Full Text Available Abstract Background Minimal invasive breast biopsy is standard care for the diagnosis of suspicious breast lesions. There are different vacuum biopsy (VB systems in use. The aim of the study was to determine the differences between the 8-gauge and the 11-gauge needle with respect to a diagnostic reliability, b complication rate and c subjective perception of pain when used for vacuum-assisted breast biopsy. Methods Between 01/2000 and 09/2004, 923 patients at St. Josefs-Hospital Wiesbaden underwent VB using the Mammotome® (Ethicon Endosurgery, Hamburg. Depending on preoperative detection, the procedure was performed under sonographic or mammographic guidance under local anaesthesia. All patients included in the study were followed up both clinically and using imaging techniques one week after the VB and a second time after a median of 41 months. Excisional biopsy on the ipsilateral breast was an exclusion criteria. Subjective pain scores were recorded on a scale of 0 – 10 (0 = no pain, 10 = unbearable pain. The mean age of the patients was 53 years (30 – 88. Results 123 patients were included in the study in total. 48 patients were biopsied with the 8-gauge needle and 75 with the 11-gauge needle. The use of the 8-gauge needle did not show any significant differences to the 11-gauge needle with regard to diagnostic reliability, complication rate and subjective perception of pain. Conclusion Our data show that there are no relevant differences between the 8-gauge and 11-gauge needle when used for VB. Under sonographic guidance, the use of the 8-gauge needle is recommended for firm breast tissue due to its sharp scalpel point and especially for complete removal of benign lesions. We did not find any advantages in the use of the larger 8-gauge needle compared to the 11-gauge needle in the mammography setting. The utilisation costs of the 8-gauge needle are somewhat higher.

  7. The Ecology of Gynecological Care for Women

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    Chia-Pei Chang


    Full Text Available Gynecological care is vital to women’s health but utilization of gynecological care has been seldom addressed. We applied the population-based “ecology model” to demonstrate the utilization of gynecological care of women, with examples from Taiwan. We analyzed the claims data from the cohort datasets within the National Health Insurance Research Database in Taiwan. Women’s utilization of gynecological care in 2009 was computed. Of 1000 women, 319 utilized gynecological care at least once, 277 visited Western medicine clinics, 193 visited physician clinics, 118 visited hospital-based outpatient clinics, 73 visited traditional Chinese medicine clinics, eight were hospitalized, four were hospitalized in an academic medical center, and four visited emergency departments. More than 90% of young and middle-aged women who sought gynecological care visited gynecologist clinics. Elderly women were less likely to utilize gynecological care in all settings of medical care, but were more likely to be attended by non-gynecologists. Young women tended to visit emergency departments. The ecology model highlighted age disparities in women’s utilization of gynecological care in various settings of medical care. Since gynecological conditions were common among women, more attention should be paid on the availability of gynecologists and continuing medical education in gynecological care for non-gynecologists to guarantee women’s health.

  8. 常见妇科疾病引起的雌激素水平变化与骨转换的关系%The relationship between the estrogen level in patients with common gynecological diseases and the bone turnover

    Institute of Scientific and Technical Information of China (English)

    范璐; 林华


    女性常见的妇科疾病如子宫内膜异位症、子宫内膜癌、乳腺癌、Sheehan综合征等,其病程中体内雌激素水平变化,直接或间接地影响骨转换水平,导致骨量变化.本文研究不同疾病状态下,疾病本身因素或手术及药物治疗对女性卵巢功能和雌激素水平的影响,从而影响骨转换率,导致继发性骨质疏松.有助于预防和治疗女性激素相关性骨量下降和骨质疏松,提高女性患者的生活质量.%The estrogen level in women varies in some gynecological disease courses.These diseases include endometriosis, endometrial cancer, breast cancer, and Sheehan's syndrome.The variety directly or indirectly influences the level of bone turnover, leading to a change in bone mass.This article studies the effect of the diseases alone or the treatment using surgery and medicine on ovarian function and estrogen level under different disease status, and further on bone turnover rate that causes secondary osteoporosis.The study may contribute to prevention and treatment of osteoporosis due to female hormone - related bone loss, and to improve life quality of women.

  9. Perioperative management of hemostasis for surgery of benign hepatic adenomas in patients with glycogen storage disease type ia. (United States)

    Mollet-Boudjemline, Alix; Hubert-Buron, Aurélie; Boyer-Neumann, Catherine; Aldea, Roxana; Franco, Dominique; Trioche-Eberschweiller, Pascale; Mas, Anne-Elisabeth; Mabille, Mylène; Labrune, Philippe; Gajdos, Vincent


    The development of hepatocellular adenomas in the liver of patients with glycogen storage disease type I is a well-known complication of the disease. Surgical procedures and perioperative managements described so far have reported persistent and important morbidity. We report here a series of six patients (three males and three females) who underwent hepatic resection, and we propose a new hemostatic management protocol comprising glucose infusion, corticosteroids, desmopressin, and antifibrinolytic drugs, used to prevent efficaciously hepatic hemorrhage due to glycogen storage disease (GSD) platelet dysfunction.

  10. Systematic review of robotic surgery in gynecology: robotic techniques compared with laparoscopy and laparotomy. (United States)

    Gala, Rajiv B; Margulies, Rebecca; Steinberg, Adam; Murphy, Miles; Lukban, James; Jeppson, Peter; Aschkenazi, Sarit; Olivera, Cedric; South, Mary; Lowenstein, Lior; Schaffer, Joseph; Balk, Ethan M; Sung, Vivian


    The Society of Gynecologic Surgeons Systematic Review Group performed a systematic review of both randomized and observational studies to compare robotic vs nonrobotic surgical approaches (laparoscopic, abdominal, and vaginal) for treatment of both benign and malignant gynecologic indications to compare surgical and patient-centered outcomes, costs, and adverse events associated with the various surgical approaches. MEDLINE and the Cochrane Central Register of Controlled Trials were searched from inception to May 15, 2012, for English-language studies with terms related to robotic surgery and gynecology. Studies of any design that included at least 30 women who had undergone robotic-assisted laparoscopic gynecologic surgery were included for review. The literature yielded 1213 citations, of which 97 full-text articles were reviewed. Forty-four studies (30 comparative and 14 noncomparative) met eligibility criteria. Study data were extracted into structured electronic forms and reconciled by a second, independent reviewer. Our analysis revealed that, compared with open surgery, robotic surgery consistently confers shorter hospital stay. The proficiency plateau seems to be lower for robotic surgery than for conventional laparoscopy. Of the various gynecologic applications, there seems to be evidence that renders robotic techniques advantageous over traditional open surgery for management of endometrial cancer. However, insofar as superiority, conflicting data are obtained when comparing robotics vs laparoscopic techniques. Therefore, the specific method of minimally invasive surgery, whether conventional laparoscopy or robotic surgery, should be tailored to patient selection, surgeon ability, and equipment availability.

  11. [Tyrosine-protein kinase activity in breast neoplasm. Comparison with activity obtained in benign diseases and in normal tissues]. (United States)

    Pierart, J; Oñate, E; Klaassen, R; Cid, L; Gutierrez, S; Talbot, E; Ross, E; Zambrano, C; Burmeister, R; Puchi, M


    Tyrosine protein kinase (TPK) activity is associated to malignant cellular transformation. This work compares TPK activity in 27 surgical biopsy samples of mammary carcinoma, 10 samples of fibroadenomas, 13 samples of fibrocystic breast disease and 27 samples of normal mammary tissue. TPK activity was determined in tissue homogenates using (Val5) angiotensin II as exogenous substrate. In samples of mammary carcinoma, TPK activity was 33.86 +/- 31.98 pmol P32/mg protein/30 min. This value was significantly higher that those observed in fibrocystic disease (3.92 +/- 2.35), fibroadenomas (13.86 +/- 10.9) and normal tissue (3.56 +/- 3.02).

  12. Update on key topics in adolescent gynecology. (United States)

    Fisher, Martin; Lara-Torre, Eduardo


    AM:STARs, the Adolescent Medicine State of the Art Reviews series published by the American Academy of Pediatrics, devoted its April 2012 issue to the topic of Adolescent Gynecology. Developed in conjunction with the North American Society for Pediatric and Adolescent Gynecology (NASPAG), the issue consists of twelve articles, written mostly by members of NASPAG. As editors of the issue, we present in this review for the Journal of Pediatric and Adolescent Gynecology (JPAG) a synopsis of the most salient concepts presented in those 12 articles. This review of reviews is intended to be an update on the "state of the art" in adolescent gynecology.

  13. Clinical application of the multi-joint testing vaginitis in diagnosis of gynecological vaginal diseases%阴道炎多联检测在妇科阴道疾病诊断中的临床应用

    Institute of Scientific and Technical Information of China (English)



    目的:探讨阴道炎多联检测在妇科阴道疾病的诊断中的临床应用.方法:对1516例阴道分泌物进行多联检测(pH值、过氧化氢浓度、白细胞脂酶、唾液酸苷酶、脯氨酸氨基肽酶、N-乙酰氨基葡萄糖苷酶)和用Amsel方法检测,并对其中正常阴道组、霉菌性阴道炎、滴虫性阴道炎和BV组进行对照比较.结果:根据临床表现和多联检测,BV的发病率高达27.2%,滴虫性阴道炎占12.5%,霉菌性阴道炎占9.0%.结论:利用多项目联合检测法检测阴道分泌物,能快速、简单、客观而有效的对阴道疾病进行辅助诊断.%Objective: To discuss the clinical application of the multi - joint testing vaginitis in diagnosis of gynecological vaginal diseases. Methods: More than 1516 cases of vaginal secretions of joint detection ( pH value, hydrogen peroxide concentration, white blood lipase, neuraminidase, proline aminopeptidase, gan enzyme acetyl glucosamine )and detected by Amsel and on which normal vaginal group, fungal vaginitis and trichomonas vaginitis and BV group for comparison. Results: Based on clinical manifestations and multi -joint testing, BV incidence rate as high as 27.2%, 12.5% trichomoniasis vaginitis, fungal vaginitis 9.0%. Conclusion: The use of multi - project joint detection assay of vaginal secretions can rapid,simple,objective and effective diagnosis vaginal diseases.

  14. Genetic instability in Gynecological Cancer

    Institute of Scientific and Technical Information of China (English)

    ZHAO Qing-hua; ZHOU Hong-lin


    Defects of mismatch repair (MMR) genes also have beenidentified in many kinds of tumors. Loss of MMR functionhas been linked to genetic instability especially microsatelliteinstability that results in high mutation rate. In this review, wediscussed the microsatellite instability observed in thegynecological tumors. We also discussed defects in the DNAmismatch repair in these tumors and their correlation to themicrosatellite instability, as well as the gene mutations due tothe microsatellite instability in these tumors. From thesediscussion, we tried to understand the mechanism ofcarcinogenesis in gynecological tumors from the aspect ofgenetic instability due to mismatch repair defects.

  15. Obstetrics and Gynecology Hospitalist Fellowships. (United States)

    Vintzileos, Anthony M


    This article establishes the rationale and development of an obstetrics and gynecology (OB/GYN) hospitalist fellowship program. The pool of OB/GYN hospitalists needs to be drastically expanded to accommodate the country's needs. Fellowship programs should provide extra training and confidence for recent resident graduates who want to pursue a hospitalist career. Fellowships should train physicians in a way that aligns their interests with those of the hospital with respect to patient care, teaching, and research. Research in the core measures should be a necessary component of the fellowship so as to provide long-term benefits for all stakeholders, including hospitals and patients.

  16. 患妇科疾病老年女性性满意度现状及干预措施%The situation of sexual satisfaction in elderly female associated with gynecological diseases,and the intervention measures to it

    Institute of Scientific and Technical Information of China (English)

    于峰; 施瑜


    性生活满意度是人类对性的主观感受,是婚姻满意度的一个重要组成部分,更是人类情感表达的不可分割的一部分。在性生活满意度中,心理健康起着主导作用。然而在老年女性中,广泛存在性功能障碍,加上随着年龄的增加,老年妇女卵巢功能衰退,雌激素水平和应激能力降低,进而影响到神经系统,各器官组织逐渐出现衰老状态,易患各种妇科疾病,这些对其性生活满意度有着重要影响。事实上,作为医务工作者,与伴随妇科疾病的老年女性行“性谈话”并非难事,同时也有义务在临床上实施一系列干预措施以改善老年女性患者的性生活质量。本课题旨在研究老年女性伴随妇科疾病的性满意现状,探讨有效的综合干预措施,以期提高老年女性性生活质量。%Sexual satisfaction is the human subjective feeling,an important component of marital satisfaction,an integral part of human emotion;in sexual satisfaction,mental health plays a dominant role. However, in older women,widespread sexual dysfunction,and with the increase of age,their ovarian function decline,the estrogen level and the ability to stress reduce,and then affect the nervous system;each organ tissue gradually appeared in aging state,which induce them susceptible to a variety of gynecological diseases;above-mentioned these issues have important impact on their sexual satisfaction. In fact,medical workers associated with older women with gynaecology disease for "sex talk" doesn't matter,also have the obligation in the implementation of a series of clinical interventions to improve the sexual life quality of senile female patients. This topic was to investigate senile female gynecologic diseases patient's sexual satisfaction status and explore comprehensive intervention and effective measures,so as to improve the quality of sexual life of elderly women.

  17. Inner Ear Disease and Benign Paroxysmal Positional Vertigo: A Critical Review of Incidence, Clinical Characteristics, and Management

    Directory of Open Access Journals (Sweden)

    M. Riga


    Full Text Available Background. This study is a review of the incidence, clinical characteristics, and management of secondary BPPV. The different subtypes of secondary BPPV are compared to each other, as well as idiopathic BPPV. Furthermore, the study highlights the coexistence of BPPV with other inner ear pathologies. Methods. A comprehensive search for articles including in the abstract information on incidence, clinical characteristics, and management of secondary BPPV was conducted within the PubMed library. Results. Different referral patterns, different diagnostic criteria used for inner ear diseases, and different patient populations have led to greatly variable incidence results. The differences regarding clinical characteristics and treatment outcomes may support the hypothesis that idiopathic BPPV and the various subtypes of secondary BPPV do not share the exact same pathophysiological mechanisms. Conclusions. Secondary BPPV is often under-diagnosed, because dizziness may be atypical and attributed to the primary inner ear pathology. Reversely, a limited number of BPPV patients may not be subjected to a full examination and characterized as idiopathic, while other inner ear diseases are underdiagnosed. A higher suspicion index for the coexistence of BPPV with other inner ear pathologies, may lead to a more integrated diagnosis and consequently to a more efficient treatment of these patients.

  18. Evaluation of quality of life pre- and post-vestibular rehabilitation in patients with benign paroxysmal positional vertigo associated with Meniere's disease

    Directory of Open Access Journals (Sweden)

    Azzi, Viviane Jacintha Bolfe


    Full Text Available Introduction: Vertigo is a symptom that impacts the patients' quality of life and may force them to cease performing activities of daily living. Here, we discuss benign paroxysmal positional vertigo (BPPV and Meniere's disease (MD, which show exacerbated symptoms when they appear in association. Vestibular rehabilitation (VR is an effective treatment in reducing vertigo, especially in conjunction with other therapies. Aim: To evaluate the quality of life of patients with BPPV and MD before and after VR. Method: We conducted a descriptive observational qualitative and quantitative case study with 12 patients aged 35 to 86 years. All patients diagnosed with BPPV and MD received treatment in the ENT clinic. The Brazilian DHI questionnaire, which assesses the quality of life with a focus on physical, emotional, and functional aspects, was used for data collection, and was completed by patients before the first session and after the fifth session of VR. Data were tested using the Shapiro-Wilk normality test, followed by Wilcoxon, Friedman, and Spearman correlation tests (p < 0.05. Results: There were significant improvements in scores for all aspects, with median changes ranging from 12 to 0 in the physical, 6 to 1 in the emotional, and 11 to 1 in the functional aspect. There were no correlations between the scores and sample characteristics. Conclusion: VR was an effective method for the treatment of patients with BPPV and MD; it improves quality of life and shows the maximal influence on physical aspect scores, regardless of age or gender.

  19. [Immunomorphological research on human breast tumors using monoclonal antibodies to intermediate filament proteins. The proliferative epithelial structures in fibrocystic disease (dysplasia) and benign tumors]. (United States)

    Gel'shteĭn, V I; Chipysheva, T A; Ermilova, V D; Litvinova, L V; Bannikov, G A


    Proliferating epithelial structures were studied immunomorphologically in 16 cases of fibrocystic disease and benign tumours. Monoclonal antibodies were used to prekeratin (PK) C12, normally specific for the lining epithelium, to prekeratin (PK) E3 and to the protein of intermediate filaments in mesenchymal cells--vimentin, normally specific for myoepithelium. The immunofluorescent analysis of the most common proliferating structures has shown that there are elements with a variable combination of PK C12, PK E3 and vimentin among the proliferating cells. While there are cells similar to normal lining epithelium (PK C12) or myoepithelium (PK E3) and/or vimentin), many cells have no analogues either among normal cells, or among cells from ductal, lobular and tubular tumour forms. Since in the most common forms of breast cancer only cells containing PK C12 were found, the immunofluorescent study with the application of monoclonal antibodies to PK C12, PK E3 and vimentin can be recommended in difficult and dubious cases for the recognition of carcinogenic or dysplastic nature of morphologically similar proliferating structures.

  20. Smoking, DNA Adducts and Number of Risk DNA Repair Alleles in Lung Cancer Cases, in Subjects with Benign Lung Diseases and in Controls

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    Marco Peluso


    Full Text Available Smoke constituents can induce DNA adducts that cause mutations and lead to lung cancer. We have analyzed DNA adducts and polymorphisms in two DNA repair genes, for example, XRCC1 Arg194Trp and Arg399Gln genes and XRCC3 Thr241Met gene, in 34 lung cancer cases in respect to 30 subjects with benign lung cancer disease and 40 healthy controls. When the study population was categorized in base to the number of risk alleles, adducts were significantly increased in individuals bearing 3-4 risk alleles (OR=4.1 95% C.I. 1.28–13.09, P=.009. A significant association with smoking was noticed in smokers for more than 40 years carrying 3-4 risk alleles (OR=36.38, 95% C.I. 1.17–1132.84, P=.040. A not statistically significant increment of lung cancer risk was observed in the same group (OR=4.54, 95% C.I. 0.33–62.93, P=.259. Our results suggest that the analysis of the number of risk alleles predicts the interindividual variation in DNA adducts of smokers and lung cancer cases.

  1. Radiation therapy of benign diseases: patterns of care study in Germany; Strahlentherapie von gutartigen Erkrankungen: eine Bestandsaufnahme fuer Deutschland

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    Seegenschmiedt, M.H. [Alfried Krupp Krankenhaus Essen (Germany). Klinik fuer Radioonkologie, Strahlentherapie und Nuklearmedizin; Katalinic, A. [Erlangen-Nuernberg Univ., Erlangen (Germany). Inst. fuer Medizinische Statistik und Dokumentation; Makoski, H.B. [Staedtische Kliniken Duisburg (Germany). Strahlenklinik; Haase, W. [St. Vincentius Krankenhaus Karlsruhe (Germany). Klinik fuer Radioonkologie und Strahlentherapie; Gademann, G. [Magdeburg Univ. (Germany). Klinik fuer Strahlentherapie; Hassenstein, E. [Krankenhaus Nordwest, Frankfurt am Main (Germany). Radioonkologische Klinik


    A questionnaire was mailed in 3 years (1994, 1995, 1996) to all radiation facilities in Germany, which assessed equipment, indications, number of patients and treatment concepts. A total of 134 (88%) institutions returned all requested data: 22 in East and 112 in West Germany; 30 in university and 104 in community/private hospitals. The average data of each institution and of all institutions were analyzed for frequencies and ratios between different regions and institutions. A mean of 2 (range 1 to 7) megavoltage (Linac/Cobalt 60) and 1.4 (range 0 to 4) orthovoltage units were available per institution; 32 (24%) institutions had no orthovoltage equipment. A mean of 20,082 patients were treated per year: 456 (2%) for inflammatory diseases (221 hidradenitis, 78 nail bed infection, 23 parotitis, 134 not specified), 12,600 (63%) for degenerative diseases (2,711 peritendinitis humeroscapularis, 1,555 epicondylitis humeri, 1,382 heel spur, 2,434 degenerative osteoarthritis, 4,518 not specified), 927 (5%) for hypertrophic diseases (146 Dupuytren's contracture, 382 keloids, 155 Peyronie's disease, 244 not specified), 1,210 (6%) for functional disorders (853 Graves' orbitopathy, 357 not specified), and 4,889 (24%) for other disorders (e.g. 3,680 heterotopic ossification prophylaxis). In univariate analysis, there were significant geographical (West vs East Germany) differences in the use of radiotherapy for inflammatory and degenerative disorders and institutional differences (university vs community/private hospitals) in the use of radiotherapy for hypertrophic and functional disorders (p<0.05). The prescribed dose concepts were mostly in the low dose range (<10 Gy), but varied widely and inconsistently within geographic regions and institution types. (orig./MG) [German] 1994, 1995 und 1996 wurde an alle strahlentherapeutischen Institutionen in Deutschland ein Fragebogen verschickt, mit dem technische Ausstattung, Indikationsspektrum, Patientenzahl und

  2. Definitions of Obstetric and Gynecologic Hospitalists. (United States)

    McCue, Brigid; Fagnant, Robert; Townsend, Arthur; Morgan, Meredith; Gandhi-List, Shefali; Colegrove, Tanner; Stosur, Harriet; Olson, Rob; Meyer, Karenmarie; Lin, Andrew; Tessmer-Tuck, Jennifer


    The obstetric hospitalist and the obstetric and gynecologic hospitalist evolved in response to diverse forces in medicine, including the need for leadership on labor and delivery units, an increasing emphasis on quality and safety in obstetrics and gynecology, the changing demographics of the obstetric and gynecologic workforce, and rising liability costs. Current (although limited) research suggests that obstetric and obstetric and gynecologic hospitalists may improve the quality and safety of obstetric care, including lower cesarean delivery rates and higher vaginal birth after cesarean delivery rates as well as lower liability costs and fewer liability events. This research is currently hampered by the use of varied terminology. The leadership of the Society of Obstetric and Gynecologic Hospitalists proposes standardized definitions of an obstetric hospitalist, an obstetric and gynecologic hospitalist, and obstetric and gynecologic hospital medicine practices to standardize communication and facilitate program implementation and research. Clinical investigations regarding obstetric and gynecologic practices (including hospitalist practices) should define inpatient coverage arrangements using these standardized definitions to allow for fair conclusions and comparisons between practices.

  3. 下尿路症候群与前列腺疾病%Lower urinary tract symptoms and benign prostatic diseases

    Institute of Scientific and Technical Information of China (English)



    下尿路症候群(lower urinary tract symptoms,LUTS)是所有排尿障碍的总称。良性前列腺增生症(benign prostatich yperplasia,BPH),良性前列腺肥大症(benign prostatic enlargement,BPE)和良性前列腺梗阻(benign prostatic obstruction,BPO)是老年男性中能引起LUTS最常见的疾病,自然病程多为缓慢进行性发展,

  4. Gynecologic and obstetric findings related to nutritional status and adherence to a gluten-free diet in Brazilian patients with celiac disease. (United States)

    Kotze, L M S


    This study shows a broad analysis of gynaecological and obstetrical disturbances in patients with celiac disease in relation to their nutritional status and adherence to a gluten-free diet. Seventy-six adult celiac patients were analyzed according to nutritional status and 18 children/adolescents to gluten-free diet adherence. As controls, 84 adults and 22 adolescents with irritable bowel syndrome were used The significant findings were observed as follow: adult celiac patients, irrespective of the nutritional status, were younger than controls, presented delayed menarche, secondary amenorrhea, a higher percentage of spontaneous abortions, anemia and hypoalbuminemia. No differences were observed regarding the number of pregnancies, age at menopause and duration of the reproductive period. After treatment, patients presented with normal pregnancies and one patient presented spontaneous abortion. The adolescents who were not adherent to gluten-free diet presented delayed menarche and secondary amenorrhea. In conclusion, gluten per se could explain the disturbances and malnutrition would worsen the disease in a consequent vicious cycle. Therefore, celiac disease should be included in the screening of reproductive disorders.


    Institute of Scientific and Technical Information of China (English)

    冷金花; 朗景和; 黄荣丽; 刘珠凤; 孙大为


    Objective. To investigate retrospectively the complications and associated factors of gynecological laparescopies.Methods. 1769 laparoscopic surgeries were carried out from January 1994 to October 1999 at our department. The procedures included 1421 surgeries of ovary and tube, 52 myomectomies and 296 cases of laproscopic-assisted vaginal hysterectomy (LAVH). A total of 312 patients had a history of prior laparotomy (17.6%). Results. Complications occured in 34 cases, the overall complication rate was 1.92%. Unintended laparotomies occured in 6 cases(0.34% ). 12 complications were associated with insertion of Veress needle or trocar and creation of pneumoperitoneum, including 5 severe emphysema and 7 vascular injuries, this figure represents 35.3% of all complications of this series. Five intraopemtive complications (14.7 % ) occured during the laparescopic surgery (3 severe bleedings, one bladder injury and one skin bum of leg caused by damaged electrode plate), laparotomy was re-quired in four of these cases. Seventeen complications occured during postoperative stage: 2 intraperitoneal hemor-rhages needing laparotomy, 2 bowel injuries, 4 nerve paresis and 9 febrile morbidities. Cordusions. Operative gynecologic laparoscopy is associated with acceptable morbidity rate, but can not be over-looked. Complication rate seems to be higher in advanced procedures such as LAVH.

  6. Application of CAO Lingxian's Characteristic Couplet Medicinals in Treatment of Gynecological Diseases%曹玲仙应用特色药对治疗妇科疾病经验

    Institute of Scientific and Technical Information of China (English)

    曾薇薇; 殷岫绮


    总结妇科名医曹玲仙教授临床运用特色药对治疗妇科疾病经验,分别有茜草配乌贼骨,主治月经量少、月经后期及闭经;葛根配知母,治疗卵巢早衰或卵巢储备功能下降患者;炒酸枣仁配茯神,治疗肝血亏虚之失眠患者;半夏配北秫米,治疗不寐伴有胃不和、大便欠畅患者;地骨皮配桑白皮,瓜蒌配石斛,分别治疗多囊卵巢综合征有高雄激素临床表现及胰岛素抵抗患者;石菖蒲配远志,主治低促性腺激素性闭经.并举案例加以说明.%Professor CAO Lingxian's experience in treating gynecological diseases with characteristic couplet medicinals is summarized as follows:madder root combined with cuttlefish bone for treatment of hypomenorrhea,delayed menstrual cycle and amenorrhea,kudzuvine root combined with common anemarrhena rhizome for treatment of premature ovarian failure and diminished ovarian reserve,spine date seed combined with poria with hostwood for treatment of insomnia caused by deficiency of liver blood,pinellia combined with north husked sorghum for treatment of insomnia accompanied by symptoms like stomach disharmony and inhibited defecation,wolfberry bark combined with white mulberry root-bark and snakegourd fruit combined with dendrobium respectively for treatment of polycystic ovary syndrome patients with high androgen and insulin resistance,grassleaf sweetflag rhizome combined with polygala root for treatment of hypogonadotropic amenorrhea.To illustrate the experience,some examples are given.

  7. Perspectives on research in gynecologic oncology. (United States)

    DeVita, V T; Wasserman, T H; Young, R C; Carter, S K


    Gynecologic cancers present unusual opportunities to explore the fruits of well-designed clinical trials to assess the value of existing treatment using a combined modality approach soon after diagnosis. Cancers of the ovary and uterus have well-defined, familiar natural histories. Pathways of spread are clear and reasons for treatment failure are often blatantly obvious. In the case of ovarian cancer, regional treatment with surgery and radiotherapy has been relatively ineffective and generally has not improved the survival statistics in the last two decades. Spread of tumor cells widely throughout the abdominal cavity outside radiation or surgical fields, even in patients with apparently early disease, is the obvious reason. Studies are underway to assess the impact of long-term postoperative adjuvant chemotherapy with L-phenylalanine mustard, an alkylating agent effective in patients with advanced disease, in early stages of ovarian cancer following surgery and or x-irradiation. The search is on for more effective drugs, or combinations of drugs, that could subsequently serve as more effective adjuvant treatments. In carcinoma of the uterine cervix, chemotherapy as an adjunct to surgery and/or radiotherapy in patients with localized, or locally inoperable disease has been poorly evaluated; little data are available and the value of many established drugs in patients with metastatic cervical cancer is undermined. Some recent evidence suggests the use of hydroxyurea, a drug that by itself is not effective in controlling tumor, may enhance the effect of radiotherapy in patients with Stage II disease. Uterine fundal cancer is often successfully treated by surgery alone. The data for the use of pre- or postoperative radiotherapy are open to considerable question. While the relative nontoxic progesterone compounds are effective in a small but significant fraction of patients with advanced uterine cancer, no properly designed clinical trial has truly evaluated their

  8. Enhanced discrimination of malignant from benign pancreatic disease by measuring the CA 19-9 antigen on specific protein carriers.

    Directory of Open Access Journals (Sweden)

    Tingting Yue

    Full Text Available The CA 19-9 assay detects a carbohydrate antigen on multiple protein carriers, some of which may be preferential carriers of the antigen in cancer. We tested the hypothesis that the measurement of the CA 19-9 antigen on individual proteins could improve performance over the standard CA 19-9 assay. We used antibody arrays to measure the levels of the CA 19-9 antigen on multiple proteins in serum or plasma samples from patients with pancreatic adenocarcinoma or pancreatitis. Sample sets from three different institutions were examined, comprising 531 individual samples. The measurement of the CA 19-9 antigen on any individual protein did not improve upon the performance of the standard CA 19-9 assay (82% sensitivity at 75% specificity for early-stage cancer, owing to diversity among patients in their CA 19-9 protein carriers. However, a subset of cancer patients with no elevation in the standard CA 19-9 assay showed elevations of the CA 19-9 antigen specifically on the proteins MUC5AC or MUC16 in all sample sets. By combining measurements of the standard CA 19-9 assay with detection of CA 19-9 on MUC5AC and MUC16, the sensitivity of cancer detection was improved relative to CA 19-9 alone in each sample set, achieving 67-80% sensitivity at 98% specificity. This finding demonstrates the value of measuring glycans on specific proteins for improving biomarker performance. Diagnostic tests with improved sensitivity for detecting pancreatic cancer could have important applications for improving the treatment and management of patients suffering from this disease.

  9. Benign Paroxysmal Positional Vertigo (BPPV) (United States)

    ... Rated Nonprofit! Volunteer. Donate. Review. Benign Paroxysmal Positional Vertigo (BPPV) BPPV is the most common vestibular disorder. Benign ... al. Diagnosis and management of benign paroxysmal positional vertigo (BPPV). CMAJ. 2003 169(7):681-693. Nuti D, ...

  10. Imaging of gynecologic emergencies; Bildgebende Diagnostik gynaekologischer Notfaelle

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, Matthias W. [Universitaetsspital Zuerich (Switzerland). Inst. fuer Diagnostische und Interventionelle Radiologie; Huisman, Thierry A.G.M. [John Hopkins Bayview Medical Center, Baltimore, MD (United States). Dept. of Imaging and Imaging Science; John Hopkins Bayview Medical Center, Baltimore, MD (United States). Dept. of Pediatrc Radiology and Pediatric Neuroradiology; Kubik, Rahel A. [Kantonsspital Baden AG, Baden (Switzerland). Inst. fuer Radiologie


    Acute abdominal pain related to the female genital organs is frequently encountered in the emergency department. Gynecological emergencies are diseases of the female reproductive system that are potentially life-threatening and peril the sexual function and fertility. In the diagnostic work-up of acute abdominal pain, a wide variety of differential diagnoses needs to be considered depending on the age of the patient and a concomitant pregnancy. There is significant clinical overlap with gastrointestinal emergencies. Therefore, imaging plays a key role in diagnosing the cause of the pain and the planning of the therapy. The aim of this review is to illustrate the significant role of imaging in frequently encountered gynecologic emergencies.

  11. Palliative and hospice care in gynecologic cancer: a review. (United States)

    Lopez-Acevedo, Micael; Lowery, William J; Lowery, Ashlei W; Lee, Paula S; Havrilesky, Laura J


    Despite the increasing availability of palliative care, oncology providers often misunderstand and underutilize these resources. The goals of palliative care are relief of suffering and provision of the best possible quality of life for both the patient and her family, regardless of where she is in the natural history of her disease. Lack of understanding and awareness of the services provided by palliative care physicians underlie barriers to referral. Oncologic providers spend a significant amount of time palliating the symptoms of cancer and its treatment; involvement of specialty palliative care providers can assist in managing the complex patient. Patients with gynecologic malignancies remain an ideal population for palliative care intervention. This review of the literature explores the current state of palliative care in the treatment of gynecologic cancers and its implications for the quality and cost of this treatment.

  12. On use of ultrasonography in obstetrics and gynecology

    Energy Technology Data Exchange (ETDEWEB)

    Woo, Kwang Suk; Lee, Yong Woo [Seoul National University Hospital, Seoul (Korea, Republic of)


    Ultrasonography is playing an very important in diagnosis of normal pregnancy and the other diseases in the fields of obstetrics and gynecology. It is mainly used B-mode and Real time linear scan for pregnancy such as fetal movement during its early stage, fetal position, placenta location and biparietal diameter during its middle stage, and amniotic fluid and placenta previa during its late stage, as well as tumor accompanying pregnancy. Ultrasonography has been extensively used in the fields of obstetrics and gynecology for obtaining detailed images of soft tissues without hazard to the fetus and pregnant woman. In view of the need for its professionalism of high degree of skill, this treatise will introduce clinical instances and images obtained in the sonography room of the Seoul National University Hospital.


    Institute of Scientific and Technical Information of China (English)

    郭毅; 生秀杰; 刘阳; 花象锋


    Objective: To compare the quality of life (QOL) for gynecologic cancer patients with different cancer sites and to assess the impact of patients' characteristics, disease parameters, and treatments on the subscale and overall QOL. Methods: A prospective study was conducted including 146 gynecologic cancer patients. QOL data were collected using the general Functional Assessment of Cancer Therapy (FACT- G) QOL questionnaire. Results: Advanced stage patients showed significantly poor physical well-being, emotional well-being, and functional well-being, as compared with early stage patients. QOL was reported higher in older patients (P=0.03), patients above high school education (P=0.004), and patients with help at home (P=0.009). Conclusion: Patients with later stage, multi- modality therapy, poor education, and little social support have the most significant impairments and need more support.

  14. Benign anatomical mistakes: incidentaloma. (United States)

    Mirilas, Petros; Skandalakis, J E


    The concept of the "incidentaloma," a totally asymptomatic nonfunctional tumor that is clinically and biochemically silent and discovered "incidentally" in a totally asymptomatic patient, is a by-product of the evolving diagnostic techniques of the last three decades. Various authors have used the concept for "incidental" findings during diagnostic workup for symptoms unrelated to adrenal disease, or for "incidental" adrenal tumors unrelated to symptoms that could potentially be of adrenal origin. "Incidentaloma" has been used to encompass a wide and heterogeneous spectrum of pathologic entities including adrenocortical and medullary tumors, benign or malignant lesions, hormonally active or inactive lesions, metastases, infections, granulomas, infiltrations, cysts and pseudocysts, hemorrhages, and pseudoadrenal masses. The term "incidentaloma" does not indicate whether the mass is functional, or malignant, or adrenocortical in origin. "Incidentaloma" has also appeared in the literature in reference to other endocrine organs such as pituitary, thyroid, and parathyroids, as well as the liver or kidney. We question the scientific justification for this neologism and suggest that it should be abolished. Questionable lesions should be clearly and simply described as "incidentally found."

  15. Benign prostate hyperplasia (BPH) - resources (United States)

    Resources - benign prostatic hyperplasia (BPH); Prostate enlargement resources; BPH resources ... The following organizations provide information on benign prostatic hyperplasia ( prostate enlargement ... Urology Care Foundation -- www. ...


    Rabinerson, David; Yeoshua, Effi; Gabbay-Ben-Ziv, Rinat


    Hypnosis is an ancient method of treatment, in which an enhanced state of mind and elevated susceptibility for suggestion of the patient, are increased. Hypnosis is executed, either by a caregiver or by the person himself (after brief training). The use of hypnosis in alleviating labor pain has been studied as of the second half of the 20th century. In early studies, the use of hypnosis for this purpose has been proven quite effective. However, later studies, performed in randomized controlled trial terms, have shown controversial results. Other studies, in which the effect of hypnosis was tested in various aspects of both obstetrics and gynecology and with different levels of success, are elaborated on in this review.

  17. Benign positional vertigo - aftercare (United States)

    Vertigo - positional - aftercare; Benign paroxysmal positional vertigo - aftercare; BPPV - aftercare; Dizziness - positional vertigo ... Your health care provider may have treated your vertigo with the Epley maneuver . These are head movements ...

  18. Polymorphisms in estrogen-metabolizing and estrogen receptor genes and the risk of developing breast cancer among a cohort of women with benign breast disease

    Directory of Open Access Journals (Sweden)

    Thuita Lucy W


    Full Text Available Abstract Background A cohort study was conducted to examine the role of genetic polymorphisms in three estrogen metabolizing enzymes (COMT, CYP1A1, CYP1B1 and the two estrogen receptors (ESR1, ESR2 in the progression of benign breast disease (BBD to breast cancer. Methods Among participants in an ongoing cohort study, 1438 Caucasian women had a breast biopsy for BBD and were successfully genotyped for at least one of the polymorphisms examined in this study. Genotypes were determined using DNA extracted from blood specimens collected in 1989. Incident cases of breast cancer occurring subsequent to BBD diagnosis up to 2003 were identified through cancer registries. Results Among all participants, the ESR2 *5772G allele was associated with a significant decrease in the risk of breast cancer among women with BBD (Odds Ratio (OR 0.38; 95% Confidence Interval (CI 0.15, 0.96. Compared to the reference wild-type genotypes, marginally significant associations with the development of breast cancer were observed between carriers of the variant ESR1 – 104062T allele (OR 0.70, 95% CI 0.45, 1.09, the variant ESR2 *38A allele (OR 1.40; 95% CI 0.88, 2.25, and the variant CYP1B1 453Ser allele (OR 1.48, 95% CI 0.95, 2.32. Conclusion The results indicate that specific polymorphisms in the CYP1B1, ESR1, and ESR2 genes may play a role in progression of BBD to breast cancer among Caucasian women. Although additional studies are needed to confirm or refute our findings, these results suggest that genetic markers may aid in the identification of women who are at risk for progression of BBD to cancer.

  19. Oxidative stress in benign prostate hyperplasia. (United States)

    Zabaiou, N; Mabed, D; Lobaccaro, J M; Lahouel, M


    To assess the status of oxidative stress in benign prostate hyperplasia, a very common disease in older men which constitutes a public health problem in Jijel, prostate tissues were obtained by transvesical adenomectomy from 10 men with benign prostate hyperplasia. We measured the cytosolic levels of malondialdehyde (MDA) and glutathione (GSH) and cytosolic enzyme activities of superoxide dismutase, catalase, glutathione peroxidase and glutathione S-transferase. The development of benign prostate hyperplasia is accompanied by impaired oxidative status by increasing levels of MDA, depletion of GSH concentrations and a decrease in the activity of all the antioxidant enzymes studied. These results have allowed us to understand a part of the aetiology of benign prostate hyperplasia related to oxidative stress.

  20. Benign Metastatic Leiomyoma Presenting as a Hemothorax

    Directory of Open Access Journals (Sweden)

    Anna M. Ponea


    Full Text Available Uterine leiomyomas have been reported to metastasize to various organs including the lungs, skeletal muscles, bone marrow, peritoneum, and heart. They may present with symptoms related to the metastases several years after hysterectomy. These tumors regress after menopause, and it is rare to detect active tumors in postmenopausal women. Despite their ability to metastasize, they are considered to be benign due to the lack of anaplasia. Pulmonary benign metastasizing leiomyoma is usually detected in the form of pulmonary nodules incidentally on imaging. Tissue biopsy of these nodules is required to identify them as benign metastasizing leiomyomas. Immunohistochemical analysis and molecular profiling may further help detect any malignant transformation in it. Untreated pulmonary benign metastasizing leiomyoma may result in the formation of cystic structures, destruction of lung parenchyma, and hemothorax and may cause respiratory failure. Surgical resection and hormonal therapy help prevent progression of this disease and provide an avenue for a cure.

  1. Benign metastatic leiomyoma presenting as a hemothorax. (United States)

    Ponea, Anna M; Marak, Creticus P; Goraya, Harmeen; Guddati, Achuta K


    Uterine leiomyomas have been reported to metastasize to various organs including the lungs, skeletal muscles, bone marrow, peritoneum, and heart. They may present with symptoms related to the metastases several years after hysterectomy. These tumors regress after menopause, and it is rare to detect active tumors in postmenopausal women. Despite their ability to metastasize, they are considered to be benign due to the lack of anaplasia. Pulmonary benign metastasizing leiomyoma is usually detected in the form of pulmonary nodules incidentally on imaging. Tissue biopsy of these nodules is required to identify them as benign metastasizing leiomyomas. Immunohistochemical analysis and molecular profiling may further help detect any malignant transformation in it. Untreated pulmonary benign metastasizing leiomyoma may result in the formation of cystic structures, destruction of lung parenchyma, and hemothorax and may cause respiratory failure. Surgical resection and hormonal therapy help prevent progression of this disease and provide an avenue for a cure.

  2. Radiology illustrated. Gynecologic imaging. 2. ed.

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Seung Hyup (ed.) [Seoul National Univ. Hospital (Korea, Republic of). Dept. of Radiology


    Up-to-date and image-oriented for use in clinical practice. Chapters are organized by disease entity for quick reference. Includes high-quality images and schematic drawings. Radiology Illustrated: Gynecologic Imaging is an up-to-date, image-oriented reference in the style of a teaching file that has been designed specifically to be of value in clinical practice. Individual chapters focus on the various imaging techniques, normal variants and congenital anomalies, and the full range of pathology. Each chapter starts with a concise overview, and abundant examples of the imaging findings are then presented. In this second edition, the range and quality of the illustrations have been enhanced, and image quality is excellent throughout. Many schematic drawings have been added to help readers memorize characteristic imaging findings through pattern recognition. The organization of chapters by disease entity will enable readers quickly to find the information they seek. Besides serving as an outstanding aid to differential diagnosis, this book will provide a user-friendly review tool for certification or recertification in radiology.

  3. Analysis of the Clinical Value of Interventional Therapy in Gynecologic and Obstetric Hemorrhage Diseases%介入治疗在妇产科出血性疾病临床应用中的价值

    Institute of Scientific and Technical Information of China (English)



    [目的]探讨介入治疗方法在剖宫产术后瘢痕妊娠、宫颈妊娠、产后出血中的应用价值.[方法]对2008年7月以来本院收治的25例剖宫产术后瘢痕妊娠、14例宫颈部妊娠、6例产后出血患者.采用Seldinger技术,将明胶海绵颗粒均匀悬混于碘佛醇中,透视下经导管缓慢注入子宫动脉应用于清宫或产后出血.[结果]瘢痕妊娠者行介入治疗后出血明显减少.宫颈妊娠者及产后出血介入治疗后即刻止血.[结论]介入治疗手术时间短、疗效显著、创伤小、保留了子宫,在妇产科出血性疾病的治疗中具有推广价值.%[Objective] To explore the value of interventional therapy in cesarean scar pregnancy, cervical gestation and postpartum hemorrhage in order to provide the new methods for the treatment of above diseases. [Methods] Twenty five patients with cesarean scar pregnancy, 14 patients with cervical gestation and 6 pa tients with postpartum hemorrhage in our hospital from July 2008 to now were analyzed retrospectively. Gelat in sponge granules were evenly mixed to iovensol by Seldinger technique and infused into uterine artery under fluoroscopy for the treatment of post curettage or postpartum hemorrhage. [Results] The hemorrhage in pa tients with cesarean scar pregnancy decreased obviously after interventional therapy. Patients with cervical ges tation and postpartum hemorrhage stopped bleeding immediately after interventional therapy. [Conclusion] In terventional therapy has advantages such as short operation time, obvious effect, less trauma and the reserva tion of the uterine. Therefore, it has the value of clinical promotion in the treatment of gynecologic and obstet ric hemorrhage diseases.

  4. Major clinical research advances in gynecologic cancer in 2015 (United States)


    In 2015, fourteen topics were selected as major research advances in gynecologic oncology. For ovarian cancer, high-level evidence for annual screening with multimodal strategy which could reduce ovarian cancer deaths was reported. The best preventive strategies with current status of evidence level were also summarized. Final report of chemotherapy or upfront surgery (CHORUS) trial of neoadjuvant chemotherapy in advanced stage ovarian cancer and individualized therapy based on gene characteristics followed. There was no sign of abating in great interest in immunotherapy as well as targeted therapies in various gynecologic cancers. The fifth Ovarian Cancer Consensus Conference which was held in November 7–9 in Tokyo was briefly introduced. For cervical cancer, update of human papillomavirus vaccines regarding two-dose regimen, 9-valent vaccine, and therapeutic vaccine was reviewed. For corpus cancer, the safety concern of power morcellation in presumed fibroids was explored again with regard to age and prevalence of corpus malignancy. Hormone therapy and endometrial cancer risk, trabectedin as an option for leiomyosarcoma, endometrial cancer and Lynch syndrome, and the radiation therapy guidelines were also discussed. In addition, adjuvant therapy in vulvar cancer and the updated of targeted therapy in gynecologic cancer were addressed. For breast cancer, palbociclib in hormone-receptor-positive advanced disease, oncotype DX Recurrence Score in low-risk patients, regional nodal irradiation to internal mammary, supraclavicular, and axillary lymph nodes, and cavity shave margins were summarized as the last topics covered in this review. PMID:27775259

  5. Reasons for diagnostic delay in gynecological malignancies

    DEFF Research Database (Denmark)

    Vandborg, Mai Partridge; Christensen, René dePont Christensen; Kragstrup, Jakob;


    Aim The primary aim of this study was to identify and describe different delay types in women with gynecologic cancer, and to analyze the relationship between diagnostic delay and a number of characteristics for patients, cancers and the health care system. Setting A cohort study of women newly...... diagnosed with gynecological cancer at the Department of Gynecology and Obstetrics at Odense University Hospital (OUH) Denmark, during a 15-month period from October 1st 2006 to December 31st 2007. Method Data were obtained from four different questionnaires, the Electronic Patient Journal (EPJ......) and The Danish Gynecological Cancer Database (DGCD). 161 women were included; ovarian cancer: 63, endometrial cancer: 50, cervical cancer: 34 and vulvar cancer: 14. Outcome measures were different delay types counted in days and the influence of four clinical important variables: Presence of alarm symptoms, age...

  6. Gynecologic Malignancies Post-LeFort Colpocleisis

    Directory of Open Access Journals (Sweden)

    Rayan Elkattah


    Full Text Available Introduction. LeFort colpocleisis (LFC is a safe and effective obliterative surgical option for older women with advanced pelvic organ prolapse who no longer desire coital activity. A major disadvantage is the limited ability to evaluate for post-LFC gynecologic malignancies. Methods. We present the first case of endometrioid ovarian cancer diagnosed after LFC and review all reported gynecologic malignancies post-LFC in the English medical literature. Results. This is the second reported ovarian cancer post-LFC and the first of the endometrioid subtype. A total of nine other gynecologic malignancies post-LFC have been reported in the English medical literature. Conclusions. Gynecologic malignancies post-LFC are rare. We propose a simple 3-step strategy in evaluating post-LFC malignancies.

  7. Dynamic contrast-enhanced MRI in the differential diagnosis of benign and malignant breast disease%动态增强MRI在乳腺良恶性疾病鉴别诊断中的价值

    Institute of Scientific and Technical Information of China (English)



    Objective To explore the value of dynamic contrast-enhanced MRI in the differential diagnosis of benign and malignant breast diseases. Methods Retrospective analysis was conducted on MRI data of 70 cases (78 breasts) with breast lesions confirmed pathologically during the period of January 2012 to June 2014, including 46 breasts of carcinoma and 32 breasts of benign diseases. MRI signs and enhanced parameters of benign and malignant breast lesions were observed, and specificity, sensitivity and accuracy were compared between dynamic contrast-enhanced MRI scan and MRI plain scan in diagnosis of breast cancer. Results The average age of patients with benign lesions was significantly lower (t=8. 225, P0. 05). Emax of malignant breast lesions was significantly higher than benign tumors, but Tmax and Slopemax were significantly lower than benign lesions ( t value was 10. 286, 11. 445 and 7. 236, all P0.05);②乳腺恶性病变峰值增强率(Emax)显著高于良性肿块,峰值时间(Tmax)、最大强化速率(Slopemax)显著低于良性病变(t值分别为10.286、11.445、7.236,均P<0.05);③乳腺恶性病变SI-Time曲线廓清型、平台型、渐进型分别为38例、6例、2例,良性病变分别为0例、5例、27例,两组比较SI-Time曲线类型分布差异有统计学意义(χ2=10.381,P<0.05);④MRI动态增强扫描检查乳腺恶性病变灵敏度、特异度及准确率分别为100%、96.88%、98.72%,均高于 MRI 平扫的78.26%、78.13%、78.20%,比较差异有统计学意义(χ2值分别为7.382、8.164、8.237,均P<0.05)。结论乳腺良恶性疾病动态增强MRI扫描具有特异性表现,具有较高的鉴别诊断参考价值。

  8. Gynecologic imaging: Current and emerging applications

    Directory of Open Access Journals (Sweden)

    Iyer V


    Full Text Available Common diagnostic challenges in gynecology and the role of imaging in their evaluation are reviewed. Etiologies of abnormal uterine bleeding identified on pelvic sonography and sonohysterography are presented. An algorithmic approach for characterizing an incidentally detected adnexal mass and use of magnetic resonance imaging for definitive diagnosis are discussed. Finally, the role of F18-fluorodeoxyglucose positron emission tomography in the management of gynecological malignancies, and pitfalls associated with their use are examined.

  9. Developmental Venous Anomaly: Benign or Not Benign (United States)

    AOKI, Rie; SRIVATANAKUL, Kittipong


    Developmental venous anomalies (DVAs), previously called venous angiomas, are the most frequently encountered cerebral vascular malformations. However, DVA is considered to be rather an extreme developmental anatomical variation of medullary veins than true malformation. DVAs are composed of dilated medullary veins converging centripetally into a large collecting venous system that drains into the superficial or deep venous system. Their etiology and mechanism are generally accepted that DVAs result from the focal arrest of the normal parenchymal vein development or occlusion of the medullary veins as a compensatory venous system. DVAs per se are benign and asymptomatic except for under certain unusual conditions. The pathomechanisms of symptomatic DVAs are divided into mechanical, flow-related causes, and idiopathic. However, in cases of DVAs associated with hemorrhage, cavernous malformations (CMs) are most often the cause rather than DVAs themselves. The coexistence of CM and DVA is common. There are some possibilities that DVA affects the formation and clinical course of CM because CM related to DVA is generally located within the drainage territory of DVA and is more aggressive than isolated CM in the literature. Brain parenchymal abnormalities surrounding DVA and cerebral varix have also been reported. These phenomena are considered to be the result of venous hypertension associated with DVAs. With the advance of diagnostic imagings, perfusion study supports this hypothesis demonstrating that some DVAs have venous congestion pattern. Although DVAs should be considered benign and clinically silent, they can have potential venous hypertension and can be vulnerable to hemodynamic changes. PMID:27250700

  10. Standardized measures of lobular involution and subsequent breast cancer risk among women with benign breast disease: a nested case-control study. (United States)

    Figueroa, Jonine D; Pfeiffer, Ruth M; Brinton, Louise A; Palakal, Maya M; Degnim, Amy C; Radisky, Derek; Hartmann, Lynn C; Frost, Marlene H; Stallings Mann, Melody L; Papathomas, Daphne; Gierach, Gretchen L; Hewitt, Stephen M; Duggan, Maire A; Visscher, Daniel; Sherman, Mark E


    Lesser degrees of terminal duct-lobular unit (TDLU) involution predict higher breast cancer risk; however, standardized measures to quantitate levels of TDLU involution have only recently been developed. We assessed whether three standardized measures of TDLU involution, with high intra/inter pathologist reproducibility in normal breast tissue, predict subsequent breast cancer risk among women in the Mayo benign breast disease (BBD) cohort. We performed a masked evaluation of biopsies from 99 women with BBD who subsequently developed breast cancer (cases) after a median of 16.9 years and 145 age-matched controls. We assessed three metrics inversely related to TDLU involution: TDLU count/mm(2), median TDLU span (microns, which approximates acini content), and median category of acini counts/TDLU (0-10; 11-20; 21-30; 31-50; >50). Associations with subsequent breast cancer risk for quartiles (or categories of acini counts) of each of these measures were assessed with multivariable conditional logistic regression to estimate odds ratios (ORs) and 95 % confidence intervals (CI). In multivariable models, women in the highest quartile compared to the lowest quartiles of TDLU counts and TDLU span measures were significantly associated with subsequent breast cancer diagnoses; TDLU counts quartile4 versus quartile1, OR = 2.44, 95 %CI 0.96-6.19, p-trend = 0.02; and TDLU spans, quartile4 versus quartile1, OR = 2.83, 95 %CI = 1.13-7.06, p-trend = 0.03. Significant associations with categorical measures of acini counts/TDLU were also observed: compared to women with median category of 25 acini counts/TDLU were at significantly higher risk, OR = 3.40, 95 %CI 1.03-11.17, p-trend = 0.032. Women with TDLU spans and TDLU count measures above the median were at further increased risk, OR = 3.75 (95 %CI 1.40-10.00, p-trend = 0.008), compared with women below the median for both of these metrics. Similar results were observed for combinatorial metrics of TDLU

  11. Determination of attitudes with gynecologic examination and anxiety of Turkish women before gynecologic examination

    Directory of Open Access Journals (Sweden)

    Nülüfer Erbil


    Full Text Available Objective: This study was planned with the purpose determination of attitudes with gynecologic examination and anxiety of Turkish women before gynecologic examination.Material & Methods: The sample of this descriptive and cross-sectional constituted by 240 women, applying for gynecologic examination in Gynecologic Policlinic of Ordu Maternity-Gynecologic and Child Hospital of who accepted to participate in the research. The data were collected with of a questionnarie form and State Anxiety Inventory. This study was made between the dates of 4 April- 30 May 2006. In the analysis of data, frequency, percentage, standart deviation, arithmetic mean, Kruskal wallis test, t test, ANOVA varience analysis, Mann –Whitney U test and Chi square test were used.Results: In the research, it was determined that the state axiety average point of women is 43.85±5,41. It was been that level anxiety of women before gynecologic examination was “middle level anxiety”. It was found that there is a significant between state anxiety inventory points according to the job and gynecologic examination experience of women order in the family with state anxiety (P=,000. Doctor’s knowledge and capability (63,8%, doctor’s knowledge giving (44,6% and doctor’s complaisant (41,7% were important in women’ doctor preferring for gynecologic examination. It was found that 37,5% of the women desired only doctor and 37,1% of the women desired their husband during gynecologic examination. It was determined that women felt uncomfortable because of nakedness genital organs of them (67,1% and negatif communication between doctor and women (39,6% in previously gynecologic examination. Women perceived feelings as embarrassment (62,5%, distress (38,8%, fear (37,9%, pain (21,7% during gynecologic examination. Expectations of women from health professionals during gynecologic examination were complaisant (45,0%, interest (28,3%, perceptiveness (24,2%.Conclusion: This study

  12. Benign Fibrous Histiocytoma

    Directory of Open Access Journals (Sweden)

    Pushpa Varma


    Full Text Available Fibrous histiocytomas (FHs are mesenchymal tumors that may be benign or malignant. Ocular involvement by FHs is infrequent and primarily limited to the orbit. Rarely, FHs can also involve the conjunctiva and perilimbal area. We report the case of a 38-year-old male with lid, conjunctival, and neck FHs. The diagnosis was confirmed by histopathology.

  13. Benign Prostatic Hyperplasia (United States)

    ... prostate gets bigger, it may press on the urethra and cause the flow of urine to be slower and less forceful. "Benign" means the enlargement isn't caused by cancer or infection. "Hyperplasia" means enlargement. SymptomsWhat are the ...

  14. 我国城市、农村妇女接受妇女常见病普查情况的差异分析%Difference analysis of common gynecological diseases screening status in urban and rural women in China

    Institute of Scientific and Technical Information of China (English)

    郑睿敏; 李丽娟; 王临虹; 李醒; 狄江丽; 方利文


    Objective To learn the difference of common gynecological diseases screening status in urban and rural women in China, so as to provide scientific basis for improving common gynecological diseases screening and making relevant policy. Methods Beijing, Fujian, Shanxi, Hubei, Anhui, Heilongjiang, Xinjiang, Sichuan, Gansu and Guangxi province were selected as study areas and cluster sampling method was used to investigate 7 261 women from December 2007 to January 2008. Results During the period of 2004 to 2006, the ratio of common gynecological diseases screening was almost the same between urban and rural women, which was 43. 0% and 40. 9% respectively. The ratio of gynecological examination, cervical cytological examination, breast examination and vaginal secretion examination in urban women was higher than that in rural women, which was 90.5% ,32.7% ,59.4% and 51.9% ,and 81.2% ,19. 1% ,41.0% and 36.7% , respectively (x2 value was 67.593, 86.618, 124.728 and 85. 006,respectively ). The ratio of pelvic ultrasound examination in rural women was higher than that in urban women, and it was 82. 9% and 71. 8% ,respectively (x =63. 670 ). The ratio of abnormal screening results in rural women was higher than that in urban women, and it was 48. 6% and 35. 6% respectively (x2 =63. 884,P < 0.05 ). The ratio was higher in rural women who were satisfied with the screening service than that in urban women, which was 86. 8% and 81.2% ,respectively (x2 =20. 762,P <0. 05 ). Conclusion The utilization degree of common gynecological diseases screening is different between urban and rural women in various age and family average monthly income groups. The influencing factors of accepting gynecological diseases screening are different between urban and rural women, and the service quality of common gynecological diseases screening conducted in urban and rural women is different. Therefore, the difference in urban and rural areas should be considered in making common gynecological

  15. Single benign metastasising leiomyoma of an inguinal lymph node.

    NARCIS (Netherlands)

    Laban, KG; Tobon-Morales, Roberto; Hodge, Janice; Schreuder, HWR


    Benign metastasising leiomyoma (BML) is a rare benign disease associated with uterine leiomyoma and history of uterine surgery. It most frequently occurs in premenopausal woman, with a pulmonary localisation, and consisting of multiple nodules. We present an uncommon case of a 69-year-old woman with

  16. Benign cephalic histiocytosis: report of four cases. (United States)

    de Luna, M L; Glikin, I; Golberg, J; Stringa, S; Schroh, R; Casas, J


    We cared for four patients with benign cephalic histiocytosis, a self-healing non-X, nonlipid cutaneous histiocytosis of children. The age of onset of the disease was 5 to 9 months, with papules and erythematous macules involving the head (mainly the cheeks), and posterior spread to the trunk and limbs in three patients. Microscopic examination of skin biopsies revealed a histiocytic infiltrate in the superficial dermis that was S100 protein-negative by immunoperoxidase (PAP method). One patient showed comma-shaped bodies and desmosomelike junctions on electron microscopy. No Birbeck's granules were present. Benign cephalic histiocytosis is a self-limiting condition that requires no treatment.

  17. Evaluation of the treatment effect of laparoscopic surgery on benign diseases of gastroesophageal junction%腹腔镜手术治疗胃食管结合部良性疾病的疗效评估

    Institute of Scientific and Technical Information of China (English)

    秦鸣放; 赵宏志


    Benign diseases of gastroesophageal junction include gastroesophageal reflux disease,hiatal hernia and achalasia of the cardia.Surgical intervention is superior in the treatment of moderate to severe cases.With the rapid development of laparoseopic technology,minimally invasive surgical procedures,such as laparoscopic fundoplication,laparoscopic rear of hiatal hernia and laparoscopic cardiamyotomy are widely applied with excellent efficacy.According to our experience and clinical study,laparoscopic surgery,with advantages of minimal trauma,rapid recovery,safety and reliable efficacy,could be the first-line treatment for benign diseases of gastroesophageal junction.%@@ 胃食管结合部良性疾病临床上以胃食管反流病、食管裂孔疝和贲门失驰缓症较为常见.针对上述疾病的中、重度患者,非手术治疗效果不佳,最终需要施行外科手术[1].

  18. Pelvic Surgical Site Infections in Gynecologic Surgery

    Directory of Open Access Journals (Sweden)

    Mark P. Lachiewicz


    Full Text Available The development of surgical site infection (SSI remains the most common complication of gynecologic surgical procedures and results in significant patient morbidity. Gynecologic procedures pose a unique challenge in that potential pathogenic microorganisms from the skin or vagina and endocervix may migrate to operative sites and can result in vaginal cuff cellulitis, pelvic cellulitis, and pelvic abscesses. Multiple host and surgical risk factors have been identified as risks that increase infectious sequelae after pelvic surgery. This paper will review these risk factors as many are modifiable and care should be taken to address such factors in order to decrease the chance of infection. We will also review the definitions, microbiology, pathogenesis, diagnosis, and management of pelvic SSIs after gynecologic surgery.

  19. [Discussion on English translation of TCM gynecologic terms]. (United States)

    Jiang, Kun; Han, Bing; Wang, Kui


    The existent problems, principles that should be observed and methods for English translation of TCM gynecological terms were discussed, and a scheme of translation for 150 TCM gynecological terms was explored.

  20. Clinical statistics of gynecologic cancers in Japan (United States)

    Nagase, Satoru


    Cervical, endometrial, and ovarian cancers, have both high morbidity and mortality among the gynecologic malignant tumors in Japan. The present study was conducted using both the population-based cancer registry and the gynecologic cancer registry to elucidate the characteristics of gynecologic malignant tumors in Japan. Based on nationwide estimates from the population-based cancer registry in Japan, the morbidities and mortality of cervical, endometrial, and ovarian cancers were obtained and used for analysis. Clinicopathologic factors for cervical cancer, endometrial cancer, ovarian cancer, including age, clinical stage, postsurgical stage, histological type, therapeutic strategy, and prognosis were retrieved from the gynecologic cancer registry published by the Japan Society of Obstetrics and Gynecology and used for analysis. The morbidities of cervical, endometrial, and ovarian cancers were 10,908, 13,606, and 9,384 women in 2012, respectively. The prevalence of endometrial cancer has significantly and consistently been increasing and represents the most common gynecologic malignant tumor in Japan. The mortalities of cervical, endometrial, and ovarian cancers were 2.1, 1.3, and 3.2 per 100,000 in 2012, respectively. In 2014, 52.2% of cervical cancer patients were classified as stage I, 22.5% as stage II, 10.2% as stage III, and 11.2% as stage IV. In addition, 71.9% of endometrial cancer patients were classified as stage I, 6.0% as stage II, 13.3% as stage III, and 7.5% as stage IV. Finally, 43.2% of ovarian cancer patients were classified as stage I, 9.1% as stage II, 27.6% as stage III, and 7.2% as stage IV. Twelve point five percent of ovarian cancer patients received neoadjuvant chemotherapy. PMID:28198168

  1. What is an Obstetrics/Gynecology Hospitalist? (United States)

    McCue, Brigid


    The obstetrics/gynecology (OB/GYN) hospitalist is the latest subspecialist to evolve from obstetrics and gynecology. Starting in 2002, academic leaders recognized the impact of such coalescing forces as the pressure to reduce maternal morbidity and mortality, stagnant reimbursements and the increasing cost of private practice, the decrease in applications for OB/GYN residencies, and the demand among practicing OB/GYNs for work/life balance. Initially coined laborist, the concept of the OB/GYN hospitalist emerged. Thinking of becoming an OB/GYN hospitalist? Here is what you need to know.

  2. Patterns of care for radiotherapy in vulvar cancer: a Gynecologic Cancer Intergroup study

    DEFF Research Database (Denmark)

    Gaffney, David K; Du Bois, Andreas; Narayan, Kailash;


    BACKGROUND: This study aimed to describe radiotherapeutic practice in the treatment of vulvar cancer in member study groups of the Gynecologic Cancer Intergroup (GCIG). METHODS: A survey was developed and distributed to representatives of the member study groups of the GCIG, targeting the use...... of radiotherapy (RT) in vulvar cancer. RESULTS: Thirty-two surveys were returned from 12 different cooperative groups. The most common indications for neoadjuvant RT include unresectable disease or International Federation of Gynecology and Obstetrics stage >/=III. For the neoadjuvant treatment of vulvar cancer...... of a broadly accepted standard. This underscores the importance of international cooperation as in GCIG to gather more reliable data for uncommon tumors in gynecologic oncology....

  3. 21 CFR 884.4550 - Gynecologic surgical laser. (United States)


    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Gynecologic surgical laser. 884.4550 Section 884....4550 Gynecologic surgical laser. (a) Identification. A gynecologic surgical laser is a continuous wave carbon dioxide laser designed to destroy tissue thermally or to remove tissue by radiant light...

  4. Advances in the use of radiation for gynecologic cancers. (United States)

    Viswanathan, Akila N


    Radiation plays an integral role in the management of gynecologic cancers. The specific regimen must be carefully coordinated based on the details of a patient's personal history and pathologic findings. An integrated multidisciplinary approach that merges pathology, radiology, medical oncology, gynecologic oncology, and radiation oncology results in a greater understanding and, ideally, better outcomes for women suffering from gynecologic cancer.

  5. Early experience with the da Vinci® surgical system robot in gynecological surgery at King Abdulaziz University Hospital

    Directory of Open Access Journals (Sweden)

    Sait KH


    Full Text Available Khalid H SaitObstetrics and Gynecology Department, Faculty of Medicine, Gynecology Oncology Unit, King Abdulaziz University Hospital, Jeddah, Saudi ArabiaBackground: The purpose of this study was to review our experience and the challenges of using the da Vinci® surgical system robot during gynecological surgery at King Abdulaziz University Hospital.Methods: A retrospective study was conducted to review all cases of robot-assisted gynecologic surgery performed at our institution between January 2008 and December 2010. The patients were reviewed for indications, complications, length of hospital stay, and conversion rate, as well as console and docking times.Results: Over the three-year period, we operated on 35 patients with benign or malignant conditions using the robot for a total of 62 surgical procedures. The docking times averaged seven minutes. The mean console times for simple hysterectomy, bilateral salpingo-oophorectomy, and bilateral pelvic lymphadenectomy were 125, 47, and 62 minutes, respectively. In four patients, laparoscopic procedures were converted to open procedures, giving a conversion rate of 6.5%. All of the conversions were among the first 15 procedures performed. The average hospital stay was 3 days. Complications occurred in five patients (14%, and none were directly related to the robotic system.Conclusion: Our early experience with the robot show that with proper training of the robotic team, technical difficulty with the robotic system is limited. There is definitely a learning curve that requires performance of gynecological surgical procedures using the robot.Keywords: da Vinci robot, gynecological surgery, laparoscopy

  6. Clustered microcalcifications without mass on mammography : benignancy vs. malignancy

    Energy Technology Data Exchange (ETDEWEB)

    Han, Yoon Hee; Do, Young Soo; Oh, Hoon Il; Kim, Ki Hwan; Chin, Soo Yil [Korean Cancer Center Hostpital, Seoul (Korea, Republic of); Cho, Byung Jae [Chung Dam Radiologic Clinics, Seoul (Korea, Republic of); Han, Heon [Chungang Gil Hospital, Seoul (Korea, Republic of); Choi, Yeun Hyeun; Han, Boo Kyung [Sam Sung Medical Center, Seoul (Korea, Republic of); Park, Jung Mi [Asan Medical Center, Seoul (Korea, Republic of)


    The purpose of this study is to evaluate the accuracy of differentiation between benign and malignant clustered microcalcifications without mass on mammogram. Fourty six mammograms of 44 patients showing clustered microcalcifications without mass were interpreted blindly by five independent observers majoring in breast imaging from different institutions. Twenty two were malignant (10 infiltrating ductal carcinomas, 12 intraductal carcinomas) and 24 were benign (all fibrocystic disease). The observers judge benignancy or malignancy of microcalcifications. The authors assess the accuracy of differential diagnosis of clustered microcalcifications. Of 24 cases proved benign microcalcifications, five radiologists correctly interpreted 20 on average as benign and of malignant 22 cases, 16 on average were correctly interpreted as malignant. The diagnostic accuracy of malignant microcalcifications was 71.8% on average(63.6%{approx}81.8%) and the diagnostic accuracy for benign microcalcifications was 83% on average(71%{approx}92%). It was 9 among total 46 cases that were misinterpreted by more than three radiologists. Among these 9 cases, malignant microcalcifications that had been misinterpreted as benign were seven, benign microcalcifications misinterpreted as malignant were two. The diagnostic accuracy of clustered malignant microcalcifications(71.8%) without mass on mammogram was lower than that of benign microcalcifications(83.3%). So, in case of suspected malignant microcalcification on mammogram, it is preferable that along with magnification view, histopathologic confirmation by core biopsy must be obtained.

  7. Lower urinary tract symptoms, benign prostatic hyperplasia/benign prostatic enlargement and erectile dysfunction: are these conditions related to vascular dysfunction? (United States)

    Shimizu, Shogo; Tsounapi, Panagiota; Shimizu, Takahiro; Honda, Masashi; Inoue, Keiji; Dimitriadis, Fotios; Saito, Motoaki


    Although the pathogenesis of lower urinary tract symptoms, benign prostatic hyperplasia/benign prostatic enlargement and erectile dysfunction is poorly understood and thought to be multifactorial, it has been traditionally recognized that these conditions increase with age. There is increasing evidence that there is an association between cardiovascular disease and lower urinary tract symptoms as well as benign prostatic hyperplasia/benign prostatic enlargement and erectile dysfunction in elderly patients. Age might activate systemic vascular risk factors, resulting in disturbed blood flow. Hypertension, diabetes, hyperlipidemia and atherosclerosis are also linked to the etiology of lower urinary tract symptoms, benign prostatic hyperplasia/benign prostatic enlargement and erectile dysfunction. In the present review, we discuss the relationship between decreased pelvic blood flow and lower urinary tract symptoms, benign prostatic hyperplasia/benign prostatic enlargement and erectile dysfunction. Furthermore, we suggest possible common mechanisms underlining these urological conditions.

  8. Pelvic fibromatoses--a rare gynecological entity. (United States)

    Buckshee, K; Mittal, S; Agarwal, N; Chellani, M


    A rare case of pelvic fibromatoses is reported. This condition is rarely encountered in gynecological practice but when encountered, creates a diagnostic and therapeutic challenge. The reported patient highlights the difficulties encountered in surgical excision (done twice) and illustrates the local aggressive growth behavior of this entity.

  9. Proposal of a formal gynecologic endoscopy curriculum. (United States)

    Morozov, Vadim; Nezhat, Ceana


    As minimally invasive surgery becomes the standard of care in the United States and around the world, the formal training of endoscopic surgeons is an issue of growing concern. With the implementation of the American Association of Gynecologic Laparoscopists/Society of Reproductive Surgeons (AAGL/SRS)-sponsored fellowship training in gynecologic endoscopy and a growing number of hands-on courses, we have the challenge of credentialing and certifying future gynecologic endoscopists. The objective of this article is to propose and to illustrate a uniform standardized core curriculum for obstetrics and gynecology residents, fellows in AAGL/SRS-sponsored fellowship programs, and participants in postgraduate courses. Consisting of 3 discrete parts, this proposal addresses formal laparoscopic training for gynecologists, already implemented and available to general surgeons, and a novel proposition for core training in hysteroscopy. The curriculum is distributed in a quarterly system with specific educational objectives in each quarter. After quarters 1 and 2, an online examination is given; after quarter 3, participants are required to take and pass a hands-on examination at a specified testing facility; and at the end of quarter 4, participants must demonstrate leadership skills in the operating room and in a teaching capacity, and promote the principles of the AAGL.

  10. Gynecologic screening in hereditary nonpolyposis colorectal cancer

    NARCIS (Netherlands)

    Rijcken, FEM; Mourits, MJE; Kleibeuker, JH; Hollema, H; van der Zee, AGJ


    Objective. In hereditary nonpolyposis colorectal cancer (HNPCC), women with a mismatch repair (MMR) gene mutation have a cumulative lifetime risk of 25-50% for endometrial cancer and 8-12% for ovarian cancer. Therefore, female members of HNPCC families are offered an annual gynecologic and transvagi

  11. Integrating Prevention into Obstetrics/Gynecology. (United States)

    Carey, J. Christopher


    Discusses formats to teach preventive medicine in obstetrics and gynecology (including learning objectives, lectures/seminars, and rounds/office practice) and evaluation methods (oral examinations, computerized question banks, objective structured clinical examinations). Offers examples from specific programs at American medical schools, including…

  12. Possibilities of electrical impedance tomography in gynecology (United States)

    V, Trokhanova O.; A, Chijova Y.; B, Okhapkin M.; V, Korjenevsky A.; S, Tuykin T.


    The paper describes results of comprehensive EIT diagnostics of mammary glands and cervix. The data were obtained from examinations of 170 patients by EIT system MEM (multi-frequency electrical impedance mammograph) and EIT system GIT (gynecological impedance tomograph). Mutual dependence is discussed.

  13. A Sexuality Curriculum for Gynecology Residents (United States)

    Levine, Stephen B.; And Others


    The summary report of an educational research program conducted with the obstetrics and gynecology residents at University Hospitals of Cleveland in 1976 is presented. The goals were to provide residents with basic knowledge about female sexual problems, assess skill and comfort in interviewing patients with sexual problems, document the effects…

  14. Therapy: a new nonsurgical therapy option for benign thyroid nodules?

    DEFF Research Database (Denmark)

    Hegedüs, Laszlo


    Despite the increasing implementation of iodization programs, benign nodular thyroid disease will remain a prevalent therapeutic concern for decades. recent research suggests that nonsurgical therapy, including radioactive iodine, radiofrequency thermal ablation and percutaneous laser ablation...

  15. Effect of intervention on clinic visiting rate of woman with gynecological diseases after disease census among retired or poverty-stricken women%退休及生活困难女性妇女病普查后就诊干预研究

    Institute of Scientific and Technical Information of China (English)

    徐丽玲; 沈晔; 何萍; 黄璧琨; 孙雄


    目的 评价社区医生督促就诊措施对上海市长宁区江苏社区退休及生活困难女性妇女病普查后就诊率的干预效果.方法 采用前瞻性干预研究设计和整群抽样方法,利用妇科普查和入户调查相结合的方法,收集714名退休及生活困难女性相关信息进行分析.结果 江苏社区2008年妇女病普查患病并接受基线随访的退休及生活困难女性共714例,普查后半年内就诊率为36.27%;社区医生上门督促后1年左右再次接受调查的共681例,就诊率为54.48%;生活困难女性基线就诊率(13.04%)低于退休女性(37.87%);受教育程度为大专及以上或初中者督促后就诊率较高,分别为48.84%和33.33%;自感疾病严重程度和基线就诊率、督促后就诊率均呈正相关(OR=2.45,95%CI=1.82~3.30;OR=5.10,95%CI=3.21~8.10).结论 退休及生活困难女性妇女病普查检出率高,就诊率低,社区医生督促就诊对于提高就诊率有一定效果.%Objective To evaluate the effect of intervention on improving chinic visiting rate of women with gynecolological diseases after disease census among retired or poverty-stricken women in a community of Shanghai.Methods The prospective intervention study was executed in 714 subjects selected with cluster sampling from all retired or poverty-stricken women registered in the community.Data were collected through a questionnaire survey and physical examination.Results Among the 714 women with at least one gynecological disease,36.27% sought medical treatment during six months after the disease survey.After a face-to-face intervention on clinic visit by community doctor,54.48% of the women sought medical treatment.A decreased clinic visiting baseline rate was detected in the poverty-stricken women( 13.04% ).An increased clinic visiting rate after the intervention of community doctor was observed in the women with education of college and above(48.84% ) and middle school (33.33%).There was a

  16. Benign duodenocolic fistula. A case presenting with acidosis

    DEFF Research Database (Denmark)

    Benn, Marianne; Nielsen, F T; Antonsen, H K


    A case of benign duodenocolic fistula as a complication to peptic ulcer disease is presented, the case being interesting for the rarity of the diagnosis and by being complicated with acidosis. The etiology, clinical features, diagnosis, and treatment are reviewed.......A case of benign duodenocolic fistula as a complication to peptic ulcer disease is presented, the case being interesting for the rarity of the diagnosis and by being complicated with acidosis. The etiology, clinical features, diagnosis, and treatment are reviewed....

  17. Group Medical Visits to Provide Gynecologic Care for Women Affected by Breast Cancer

    Directory of Open Access Journals (Sweden)

    Sally R. Greenwald


    Full Text Available Purpose: Women with breast cancer have complex and unique gynecologic needs that are challenging to effectively and comprehensively meet in a traditional gynecology visit format. Group medical visits are an effective and well-received model of care in other disease settings and can provide comprehensive health education as an adjunct to one-on-one evaluation and treatment. There are limited data regarding the use of this type of health care delivery in providing gynecology-focused care to women affected by breast cancer. Methods: A group medical visit model was created for gynecology providers to see new breast cancer patient consults. From May 2012 to February 2014, 148 patients (3–6 per group participated in a 1-hour informational session followed by a 15- to 30-minute individual visit with a physician that included history, physical examination and evaluation. We surveyed 101 women who attended these visits to evaluate a group model for providing gynecologic care and educational support to women with breast cancer. Results: Of those who responded to the survey question, 100% agreed or somewhat agreed that their expectations for an initial intake visit were met during the group visit; 81% agreed or somewhat agreed that they felt a group visit was preferable to an individual introductory visit. More than 95% agreed or somewhat agreed that the information was understandable and their questions were answered during the visit. Only 5 respondents expressed dissatisfaction with the additional time commitment for this type of visit. Conclusions: The majority of women surveyed expressed satisfaction with their experience with a group visit format. The women who participated preferred this format compared to an individual intake appointment when establishing gynecology care after breast cancer diagnosis/treatment, regardless of age, menopausal status, cancer stage or hormone receptor status. While further studies are warranted to directly compare and

  18. 成都地区30~50岁环卫和白领女性妇科疾病发病状况调查%Investigation of Gynecological Disease for 30~50 Years Old Sanitation and White-collar Females in Chengdu

    Institute of Scientific and Technical Information of China (English)

    袁春梅; 王玲; 张红; 王巧蓉


    Objective To know the health status of women of sanitation workers and white-collars in Chengdu,and to ana-lyze the difference between two groups in order to providing the basis data for health education and preventing the Gynecological diseases.Methods The medical examination of gynecological diseases for sanitation women and white-collars women whose age is 30~50 lompere the incidence of the two groups.Results Top four gynecological diseases in the study are chronic cervicitis, uter-ine myoma, ascites and Annex anomaly.The morbidity of chronic cervicitis in sanitation women is significant higher than white-collars women.But,the morbidity of uterine myoma in white-collars women is significantly higher than in sanitation women.In sani-tation women and white-collars women, the morbidities of chronic cervicitis in 30~40 group are significantly higher than 40~50 group; however, the morbidities of uterine myoma, ascites in 40 ~ 50 group are significantly higher than 30 ~ 40 group.Conclusion For 30~40 year old women, chronic cervicitis is the prevention focus, but, uterine myoma is more important in 40~50 year old women.The health education should be given and health examination should be encouraged for women.These methods could raise health awareness of sanitation women, improve the sports consciousness of white-collar women, to prevent or reduce the morbidities of Gynecological diseases.%目的了解成都地区环卫和白领女性妇科疾病的患病状况及原因,为开展健康教育及妇科疾病的防治提供依据。方法对30~50岁的环卫和白领女性进行妇科疾病检测,比较两组的发病情况。结果成都30~50岁环卫和白领女性中妇科疾病前四位分别是慢性宫颈炎、子宫肌瘤、盆腔积液及附件异常。环卫女工慢性宫颈炎的发病率显著高于白领女性,而白领女性子宫肌瘤的发病率显著高于环卫女性,P<0.05;两组内30~40岁组慢性宫颈炎的发病率高于40~50岁组(P<0.05),而40

  19. Effect of Simotang ( 四磨汤 ) Oral Liquid on Anal Exhaust in Patients after Abdominal Gynecological Operation

    Institute of Scientific and Technical Information of China (English)

    CHEN Sheng-ping; WANG Xiang-ping


    Objective: To study the effect of Simotang (四磨汤) oral liquid and glycerin enema on the patients' bowel sound (BS) restoration and anal exhaust after abdominal gynecological operation. Method:Ninety patients with benign tumor who had undergone gynecological operation were randomly divided into the Simotang group, treated after operation with Simotang oral liquid; the enema group, treated with glycerin enema, and the control group, non-treated. The restoration time of BS and anal exhaust were observed. Results: Compared with the control group, the restoration time of BS and anus exhaust were both significantly shorter in the Simotang group and the enema group, showing statistical significance (P<0.05); but the difference between the two treated groups was insignificant ( P>0.05). Conclusion: Simotang oral liquid and glycerine enema both could benefit the restoration of anal exhaust and BS after abdominal operation.

  20. Challenges associated with the management of gynecological cancers in a tertiary hospital in South East Nigeria

    Directory of Open Access Journals (Sweden)

    Iyoke CA


    Full Text Available Chukwuemeka Anthony Iyoke,1 George Onyemaechi Ugwu,1 Euzebus Chinonye Ezugwu,1 Frank Okechukwu Ezugwu,2 Osaheni Lucky Lawani,3 Azubuike Kanayo Onyebuchi3 1Department of Obstetrics and Gynaecology, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, 2Department of Obstetrics and Gynaecology, Enugu State University Teaching Hospital, Park Lane, Enugu, 3Department of Obstetrics and Gynaecology, Federal Teaching Hospital, Abakaliki, Ebonyi State, Nigeria Background: There are reports of increasing incidence of gynecological cancers in developing countries and this trend increases the need for more attention to gynecological cancer care in these countries. Objective: The purpose of this study was to describe the presentation and treatment of gynecological cancers and identify barriers to successful gynecological cancer treatment in a tertiary hospital in South East Nigeria. Methods: This study was a retrospective longitudinal analysis of the presentation and treatment of histologically diagnosed primary gynecological cancers from 2000 to 2010. Analysis was by descriptive and inferential statistics at the 95% level of confidence using Statistical Package for the Social Sciences version 17 software. Results: Records of 200 gynecological cancers managed during the study period were analyzed. Over 94% of cervical cancers presented in advanced stages of the disease and received palliative/symptomatic treatment. Only 1.9% of cervical cancer patients had radical surgical intervention, and postoperative mortality from these radical surgeries was 100%. Approximately 76% of patients with ovarian cancer had debulking surgery as the mainstay of treatment followed by adjuvant chemotherapy. Postoperative mortality from ovarian cancer surgery was 63%. Cutting edge cytotoxic drugs were not used as chemotherapy for ovarian and chorionic cancers. Compliance with chemotherapy was poor, with over 70% of ovarian cancer patients failing to complete the

  1. Robot-assisted surgery in gynecological oncology

    DEFF Research Database (Denmark)

    Kristensen, Steffen E; Mosgaard, Berit J; Rosendahl, Mikkel


    INTRODUCTION: Robot-assisted surgery has become more widespread in gynecological oncology. The purpose of this systematic review is to present current knowledge on robot-assisted surgery, and to clarify and discuss controversies that have arisen alongside the development and deployment. MATERIAL...... AND METHODS: A database search in PubMed and EMBASE was performed up until 4 March 2016. The search strategy was developed in collaboration with an information specialist, and by application of the PRISMA guidelines. Human participants and English language were the only restrictive filters applied. Selection...... was performed by screening of titles and abstracts, and by full text scrutiny. From 2001 to 2016, a total of 76 references were included. RESULTS: Robot-assisted surgery in gynecological oncology has increased, and current knowledge supports that the oncological safety is similar, compared with previous...

  2. Benign paroxysmal positional vertigo recurrence and persistence


    Ricardo S. Dorigueto; Mazzetti,Karen R; Gabilan,Yeda Pereira L; Ganança, Fernando Freitas [UNIFESP


    Benign paroxysmal positional vertigo (BPPV) is one of the most common vestibular disorders. AIM: To study the recurrence and persistence of BPPV in patients treated with canalith repositioning maneuvers (CRM) during the period of one year. STUDY DESIGN: longitudinal contemporary cohort series. MATERIALS AND METHODS: One hundred patients with BPPV were followed up during 12 months after a treatment with CRM. Patients were classified according to disease evolution. Aquatic physiotherapy for ves...

  3. [Benign prostatic hypertrophy and prostate cancer]. (United States)

    Mourey, Loïc; Doumerc, Nicolas; Gaudin, Clément; Gérard, Stéphane; Balardy, Laurent


    Prostatic diseases are extremely common, especially in older men. Amongst them, benign prostatic hypertrophy may affect significantly the quality of life of patients by the symptoms it causes. It requires appropriate care. Prostate cancer is the second most common cancer in men after lung cancer and the fifth leading cause of cancer deaths in the world. It affects preferentially older men. An oncogeriatric approach is required for personalised care.

  4. Benign paroxysmal positional vertigo

    Directory of Open Access Journals (Sweden)

    Guo Xiang-Dong


    Full Text Available Benign paroxysmal positional vertigo (BPPV is a common clinical disorder characterized by brief recurrent spells of vertigo often brought about by certain head position changes as may occur with looking up, turning over in bed, or straightening up after bending over. It is important to understand BPPV not only because it may avert expensive and often unnecessary testing, but also because treatment is rapid, easy, and effective in >90% of cases. The diagnosis of BPPV can be made based on the history and examination. Patients usually report episodes of spinning evoked by certain movements, such as lying back or getting out of bed, turning in bed, looking up, or straightening after bending over. At present, the generally accepted recurrence rate of BPPV after successful treatment is 40%-50% at 5 years of average follow-up. There does appear to be a subset of individuals prone to multiple recurrences.

  5. [Acute benign cerebral angiopathy. 6 cases]. (United States)

    Rousseaux, P; Scherpereel, B; Bernard, M H; Guyot, J F


    The 6 cases reported here constitute, with 5 previously published cases, a special nosological entity tentatively called "acute benign cerebral angiopathy" by the authors. These 11 cases have in common certain radiological and clinical features. Arteriography shows segmental, multifocal and assymetrical stenoses involving the cerebral arteries between Willis' circle and the terminal arterioles and looking like "strings of sausages". The lesions disappear within one month and present the radiological characteristics of arteritis of medium caliber vessels. The clinical symptoms are suggestive of meningeal haemorrhage or acute cerebromeningeal oedema, with acute repetitive attacks of severe headache and agitation with obnubilation; epileptic seizures and transient neurological deficit may occur. True meningeal haemorrhage confirmed by lumbar puncture is seen in nearly one half of the cases; it seems to be due to alterations in the blood-brain barrier induced by the angiopathy. Intracerebral haematoma may develop, but the disease is usually benign and regresses spontaneously in a few days. None of the usual causes of cerebral arteritis (intra-cranial infection, collagen disease, allergic or toxic angitis) has been found. Pseudo-arteritis (notably spasm of ruptured arterial aneurysms) has been excluded. No aetiological factor common to the 11 cases reported has been elicited, although 6 of the patients had recently given birth and our 6 patients had benign virus infection before or during the clinical manifestations of the disease. In the authors' opinion, the most rewarding line of research would be the role of short acute attacks of arterial hypertension.

  6. The future of lasers in gynecology (United States)

    Keye, William R.


    There were many claims of extraordinary possibilities for laser surgery by the early gynecologic laser surgeons. They promised that by using the laser there would be increased speed of the operation, decreased blood loss, decreased infection rates, decreased thermal damage and finally increased clinical results. Despite this `hype,' our clinical experience over the last decade has demonstrated in a large part that the clinical results using the laser are equivalent to those using either sharp scalpel or electrocautery. It appears that the skill of the surgeon is a far more important variable than the type of instrument used by the surgeon. As a result, since 1990, the laser has begun to fall out of favor with gynecologists and, more recently, general surgeons. The gynecologic surgeon of the 1990s is now exploring the use of intra-abdominal endoscopically delivered sutures and staples as well as electrocautery. Considering the increased expense associated with lasers, it is likely that a gynecologic surgeon will continue to explore non-laser options in the future. With planning and cooperation and consultation between clinicians, basic scientists and industry, lasers may ultimately play an even more significant role than they have in the 1980s.

  7. 良性血性胸腔积液42例临床诊断分析%Clinical Analysis of 42 Cases with Bloody Pleural Effusion Caused by Benign Disease

    Institute of Scientific and Technical Information of China (English)

    王剑利; 杨硕; 俞珊; 李净; 陈红兵


    目的 探讨不同病因引起的良性血性胸腔积液的临床特点.方法 分析我院收治的42例良性血性胸腔积液患者的临床资料.结果 42例患者中有结核性胸膜炎27例,占62.8%,其他良性疾病15例(其中肺炎旁4例,系统性红斑狼疮性3例,类风湿性关节炎2例,充血性心力衰竭2例,结节病1例,肝硬化2例,慢性胰腺炎1例),这些患者在既往史、症状及实验室检查等方面各有其特点.结论 良性血性胸腔积液以结核性胸膜炎为主,亦见于其他良性疾病,如果排除恶性肿瘤,且抗结核治疗效果欠佳,则需仔细询问患者既往史,完善有针对性的实验室检查尽早明确病因,积极治疗原发病以改善预后.%Objective To analyze the clinical characteristics of benign bloody pleural effusion from various causes. Methods Analyzed of clinical data of 42 cases with bloody pleural effusion. Results Among 42 patients, 27 cases of the bloody pleural effusion caused by tuberculous pleural effusions( 62. 8% ),15 cases caused by other benign disease( 4 cases of pneumonia, 3 cases of systemic lupus eritematosus, 2 cases of rheumatoid arthritis, 2 cases of congestive heart failure, a case of sarcoidosis, 2 cases of hepatic cirrhosis, and a case of chronic pancreatitis ). These patients' past history, simultaneous symptoms and laboratory examination results were looked at. Conclusion Most bloody pleural effusions caused by tuberculous pleuritis, also other benign diseases. When the possibilities of malignant tumors were excluded and tuberculosis treatment has poor curative effects, it is critical to enquire about the past history of patients thoroughly and to take additional related examinations in order toto determine the diagnosis early, treat properly and improve prognosis.

  8. Natural history of benign prostate hyperplasia

    Institute of Scientific and Technical Information of China (English)

    WU Shi-liang; LI Ning-chen; XIAO Yun-xiang; JIN Jie; QIU Shao-peng; YE Zhang-qun; KONG Chui-ze; SUN Guang; NA Yan-qun


    Background Benign prostate hyperplasia is one of the most common diseases affecting the health of the aging males. Watchful waiting is an acceptable management strategy for benign prostate hyperplasia in which the patient is monitored by the physician but receives no active intervention. The epidemiological data on this are lacking in China. Our study was designed to evaluate the changes of signs and symptoms of patients with benign prostate hyperplasia during management by watchful waiting in China.Methods One hundred and forty-five patients with benign prostate hyperplasia aged > 50 years were enrolled in management by watchful waiting. All the patients were visited every 6 months and were given an International Prostate Symptom Score and Quality of Life questionnaire to complete. They also had uroflowmetry and were assessed using ultrasonography to get the volume of prostate, transition zone and amount of residual urine. The Student's t test, the Chi-square test, and variance analysis were used in the statistical analysis.Results All patients were visited after 6 months, the mean volume of transitional zone was found to haveincreased by 1.6 ml (P<0.01), International Prostate Symptom Score was increased by 0.8 (P<0.01) and Quality of Life was increased by 0.2 (P<0.01), and there was no statistical change in other data. Among these patients,17.9% (26/145) visited again after 12 months when the data failed to show a statistically significant difference among the three groups (0, 6, and 12 months).Conclusions After one year's follow-up, the progression of benign prostate hyperplasia was slow and the clinical data did not undergo much change.

  9. Novel nanomedicine-based MRI contrast agents for gynecological malignancies. (United States)

    Mody, Vicky V; Nounou, Mohamed Ismail; Bikram, Malavosklish


    Gynecological cancers result in significant morbidity and mortality in women despite advances in treatment and diagnosis. This is due to detection of the disease in the late stages following metastatic spread in which treatment options become limited and may not result in positive outcomes. In addition, traditional contrast agents are not very effective in detecting primary metastatic tumors and cells due to a lack of specificity and sensitivity of the diagnostic tools, which limits their effectiveness. Recently, the field of nanomedicine-based contrast agents offers a great opportunity to develop highly sophisticated devices that can overcome many traditional hurdles of contrast agents including solubility, cell-specific targeting, toxicities, and immunological responses. These nanomedicine-based contrast agents including liposomes, micelles, dendrimers, multifunctional magnetic polymeric nanohybrids, fullerenes, and nanotubes represent improvements over their traditional counterparts, which can significantly advance the field of molecular imaging.

  10. Combination of signal intensity measurements of lesions in the peripheral zone of prostate with MRI and serum PSA level for differentiating benign disease from prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Engelhard, K.; Kreckel, M. [Department of Radiology, Martha-Maria Hospital Nuernberg (Germany); Hollenbach, H.P.; Deimling, M. [Siemens Medical Engineering Group, Erlangen (Germany); Riedl, C. [Dept. of Urology, University of Erlangen-Nuernberg, Erlangen (Germany)


    The aim of this study was to predict the benign or malignant nature of a prostatic lesion by defining a threshold value of signal intensity ratio and a limiting value of serum prostate-specific antigen (PSA) in patients with elevated PSA level. Twenty-six patients with elevated PSA level and no hypoechogenic lesions at endosonography underwent MR imaging using an endorectal body phased-array coil at 1.5 T (Siemens Magnetom Symphony). A T2-weighted turbo-spin-echo (TSE) pulse sequence was applied in a transverse orientation. Two radiologists evaluated the images. In the presence of a pathological finding they defined regions of interest (ROI) in the suspicious pathological area of the peripheral zone and in muscle for reference. The quotient of the two ROIs was calculated and then correlated with the actual PSA level. Diagnosis was confirmed by prostate biopsy. Ten of 12 patients with quotients smaller than 4 showed cancer at histology. Nine of 12 men with cancer proven by biopsy had PSA levels higher than 10 ng/ml. A significant difference (p < 0.001) was found between the quotients of cancer and quotients of chronic prostatitis, fibrosis, or glandular atrophy. The accuracy of tumor differentiation of the method was 77 %. Measurement of signal intensity quotients in the peripheral zone of the prostate in combination with knowledge of defined limits of PSA levels the technique could be helpful in detecting additional cancer areas for prostate biopsy. False-negative tumor results of standard sextant biopsy can be reduced. In men with high PSA values the method has a role in differentiating between patients who require prostate biopsy and those of clinical observation. (orig.)

  11. Synchronous gynecologic cancer and the use of imaging for diagnosis. (United States)

    Boaventura, Camila Silva; Galvão, José Lucas Scarpinetti; Soares, Giovanna Milanes Bego; Bitencourt, Almir Galvão Vieira; Chojniak, Rubens; Bringel, Shenia Lauanna Rezende; Brot, Louise De


    Endometrial and cervical cancers are the most prevalent gynecologic neoplasms. While endometrial cancer occurs in older women, cervical cancer is more prevalente in young subjects. The most common clinical manifestation in these two gynecological cancers is vaginal bleeding. In the first case, diagnosis is made based on histological and imaging evaluation of the endometrium, while cervical cancers are diagnosed clinically, according to the International Federation of Gynecology and Obstetrics (FIGO). The authors present a case of synchronous gynecological cancer of the endometrium and cervix diagnosed during staging on MRI and confirmed by histological analysis of the surgical specimen.

  12. Breast and Gynecologic Cancer | Division of Cancer Prevention (United States)

    [[{"fid":"184","view_mode":"default","fields":{"format":"default","field_file_image_alt_text[und][0][value]":"Breast and Gynecologic Cancer Research Group Homepage Logo","field_file_image_title_text[und][0][value]":"Breast and Gynecologic Cancer Research Group Homepage Logo","field_folder[und]":"15"},"type":"media","attributes":{"alt":"Breast and Gynecologic Cancer Research Group Homepage Logo","title":"Breast and Gynecologic Cancer Research Group Homepage Logo","height":"266","width":"400"," | Prevention and early detection of breast, cervix, endometrial and ovarian cancers and their precursors.

  13. Gynecological endoscopic surgery in Cienfuegos.

    Directory of Open Access Journals (Sweden)

    Alberto Jorge Fernández


    Full Text Available Background: In the last few years less invasive techniques for patients have been developed and endoscopic surgery is important example. Objective: To determine the advantages of endoscopic surgery and to relate ultrasonographic findings with surgical diagnoses. Method: Case study of 73 surgeries performed by gynaecological endoscopic surgery at the University Hospital ¨Dr. Gustavo Aldereguía Lima¨ from Cienfuegos province in the period January 1998- May 2002. urgencies and and Salpingoclasias were excluded from this search. The statistical study included tests of percentage, accumulated frequency, Kappla´s index, mean and standard deviation. Results: The most recent gynaecological pathologies were: Pelvic Inflammatory Disease, infertility and ovarian cyst. The relationship between ultrasonographic and surgical diagnosis was good for P.I.D and the intrauterine device in the abdominal cavity but not for endometritis. The most frequent laparoscopic procedures were salpingovariolasis and fimbrioplasty , ovarian cystectomy and contrasted laparoscopy. The two complications were bleeding which was controlled and facial subcutaneous emphysema.

  14. Benign paroxysmal positional vertigo following septorhinoplasty. (United States)

    Koc, Eltaf Ayca Ozbal; Koc, Bulent; Eryaman, Esra; Ozluoglu, Levent N


    We present 2 cases of benign paroxysmal positional vertigo (BPPV) following septorhinoplasty. Benign paroxysmal positional vertigo following septorhinoplasty is an unusual entity. Two young women who had difficulty in breathing and nasal deformity underwent septorhinoplasty. On the second and the third postoperative days, the patients experienced vertigo that was induced by position changes. Both patients had neither preexisting ear disease nor vertigo before the surgery. All the examinations were normal. With Dix-Hallpike maneuver, which is the criterion-standard test, the characteristic nystagmus was observed. Right posterior canal BPPV was diagnosed, and they were both treated with Epley canalith repositioning maneuver. Publications related to postsurgical vertigo are available in literature, but it is still an underdiagnosed disorder. We would like to mention about this rare entity and inform the surgeons that they must keep in mind that a patient who is complaining about vertigo or dizziness after the surgery should be observed and investigated for BPPV.

  15. Der benigne paroxysmale Lagerungsschwindel

    Directory of Open Access Journals (Sweden)

    Wiest G


    Full Text Available Der benigne paroxysmale Lagerungsschwindel (BPPV ist eine häufige Störung des peripheren Vestibularorgans, welche bei allen Patienten mit lageabhängigem Schwindel suspiziert werden sollte. Obwohl kurzzeitige Drehschwindelattacken als pathognomonisches Symptom gelten, weisen viele Patienten auch unsystematisierten Schwankschwindel auf, was die Diagnosestellung oft erschwert. Auslöser des BPPV sind Klziumkarbonatkristalle (Otokonien, welche sich aus der Otolithenmatrix des Utriculus lösen und in einen der drei Bogengänge gelangen. Die Diagnosestellung erfolgt mit spezifischen Provokations- bzw. Lagerungstests, um den entsprechenden Lagerungsschwindel und Nystagmus zu induzieren. Die von Semont und Epley entwickelten Befreiungsmanöver zielen darauf ab, die in den Bogengängen lokalisierten Partikel in den Utriculus zu repositionieren, wo sie keinen Drehschwindel mehr auslösen. Zur Unterscheidung des BPPV von einem zentralen Lageschwindel bzw. Nystagmus können neben der Latenz auch der Verlauf und die Dauer des Lagerungsnystagmus beitragen, von entscheidender Bedeutung in der Differentialdiagnose ist allerdings die Schlagrichtung des induzierten Nystagmus.

  16. Nihilism: a benign denial. (United States)

    Skandalakis, John E; Mirilas, Petros


    Nihilism is the belief that all possible knowledge on a given topic has been amassed and codified. Ranging from benign denial to deliberate attempts at excommunication, nihilism is often encountered in the history of medicine. Eustachius, Columbus, and Sylvius strongly criticized Vesalius and defended the authority of Galen. Riolan fervently rejected Harvey's monumental work on the circulation of blood. Gross stated that no honest and sensible surgeon would ever sanction thyroidectomy. Sandstrom's discovery of the parathyroids was met with silence. Transplantation of parathyroids by Mandl was not appreciated when announced. Aristotle's dictum that the heart cannot withstand serious injury led to Paget's statement that cardiac surgery had reached the limits set by nature, which no new techniques could overcome. The first Billroth I operation was welcomed as, "Hopefully, also the last." Pancreatic surgery was opposed because the organ was of no clinical interest and was impossible for surgeons to reach. Pancreatic transplantation was rejected for many years, despite good results. When Blundell used blood transfusion for postpartum hemorrhage, critics averred that his next exploit would be radical removal of the spleen. Bassini stated that it could be risky to publish more about radical treatment of inguinal hernias. Carcinomas of the lower sigmoid and upper rectum were deemed untreatable because of their inaccessibility. Colostomy during pediatric surgery was rejected many times. Although it is difficult for the human mind to move from a familiar point of view, this propensity should not infect science, thereby impeding advancement.

  17. Proof of concept of the WOMED model of benign thyroid disease: Restitution of thyroid morphology after correction of physical and psychological stressors and magnesium supplementation

    Directory of Open Access Journals (Sweden)

    Roy Moncayo


    General significance: Our results challenge validity of the prevailing dogma of a destructive unstoppable “autoimmune” destructive process of the gland. At the same time it shows new therapeutic options for patients with thyroid disease.

  18. Unilateral Pigmented Extramammary Paget's Disease of the Axilla Associated with a Benign Mole: A Case Study and a Review of Literature


    Ladak, Aleem; Bramley, Maria; Titi, Sami


    Pigmented extramammary Paget's disease (PEMPD) is an uncommon intraepithelial adenocarcinoma and a rare variant of Paget's disease affecting skin that is rich in apocrine sweat glands such as the axilla, perianal region and vulva. It most commonly occurs in postmenopausal women and presents as a superficial pigmented scaly macule, mimicking a melanocytic lesion. The histological presentation is adenocarcinoma in situ with an increased number of melanocytes scattered between the Paget's cells....

  19. 妇科腹腔镜日间手术62例临床分析%Gynecological laparoscopic ambulatory surgery: A clinical analysis of 62 cases

    Institute of Scientific and Technical Information of China (English)

    刘海防; 陈旭; 刘彦; 孔玉屏


    目的 探讨腹腔镜日间手术在妇科应用的可行性和安全性.方法 收集2010年9月至2013年1月在本院及上海沃德医疗中心手术室进行的妇科腹腔镜日间手术62例,患者均实施全身麻醉,总结分析手术时间、术中出血量、术后疼痛评分、恶心与呕吐评分、患者满意度评分.结果 患者手术时间为(38.06±15.50)min,术中出血量为(30.40±18.98)ml,术后疼痛评分为2(1,3)分,术后呕吐评分为2(1,2),患者满意度评分为(95.21±3.74)分.所有患者均于手术当日17时前离开医院,术后4d内全部恢复正常工作.结论 良性妇科疾病的腹腔镜日间手术是可行且安全有效的.减少手术时间和出血量,并加强麻醉后镇痛和止吐处理可以提高患者满意度.%Objective To investigate the feasibility and safety of gynecological laparoscopic surgery in an ambulatory surgery center.Methods Between September 2010 and January 2013,62 patients who received laparoscopic surgeries under general anesthesia for benign gynecological diseases in the ambulatory operation room of our hospital and Shanghai Worldpath Clinic International Center were recruited.The duration of operation,loss of blood,post-operative pain,nausea-vomiting score and patients' satisfaction were summarized.Results The duration of operation was (38.06±15.50)min.The loss of blood was (30.40± 18.98) ml.The post-operative pain scale,2 (1,3).The nausea-vomiting score was 2 (1,2).Patients' satisfaction was 95.21±3.74.All the patients were discharged before 5 PM the some day following the surgery and resumed their work within 4 days.Conclusion Gynecological laparoscopic ambulatory surgery,which is associated with a shorter duration of operation,reduced loss of blood and improved patients' satisfaction following appropriate analgesia and anti-emetic therapy,can be feasible and safe in patients with benign diseases.

  20. Transumbilical single incision laparoscopic cholecystectomy for gallbladder benign diseases:A report of 80 cases%经脐单孔腹腔镜下胆囊切除术应用体会(附80例报告)

    Institute of Scientific and Technical Information of China (English)

    江弢; 孙晶; 岑刚; 裘正军


    Objective To investigate a single surgeon' s learning curve of transumbilical single incision laparoscopic cholecystectomy ( SILC ) in the treatment of gallbladder benign diseases. Methods Eighty patients with gallbladder benign disease accepted SILC operated by a single experienced laparoscopic surgeon. The operation was performed following the routine LC procedure. The perioperative data were recorded and the learning curve was defined by the operation time. Results Eighty patients accepted SILC successfully,including 56 cases of gallbladder stones, 16 cases of cholesterol polyps,3 cases of adenomatous polyp, 1 case of adenomyomatosis and 4 cases of complex diseases. No patients were converted to conventional LC or open surgery. The average operative duration was 46.9 ± 14.6 min. The average postoperative hospital stay was 1.8 ± 1.3 days. There was no perioperative complication. The learning curve of the SILC procedures indicated the first 40 cases as a learning phase for an experienced laparoscopic surgeon.Conclusion SILC is an easy and safe procedure for experienced laparoscopic surgeons. There are significant benefits as milder pain,lower incidence of port - related complications, better cosmetology and faster recovery. SILC may become another option for the treatment of gallbladder benign diseases.%目的 了解胆囊良性疾病行经脐单孔腹腔镜下胆囊切除术(SILC)的学习曲线.方法 80例胆囊良性疾病患者按常规手术步骤行SILC,记录并分析围手术期相关资料,以手术时间定义学习曲线.结果 80例患者成功接受SILC,其中胆囊结石56例,胆固醇性息肉16例,腺瘤性息肉3例,胆囊腺肌症1例和胆囊复杂病例4例,无患者中转为传统腹腔镜下胆囊切除术或开放手术.平均手术时间为(46.9±14.6)min,平均术后住院时间为(1.8±1.3)d.无围手术期并发症.学习曲线显示有经验的腹腔镜医师需要积累40例左右的手术经验才能度过学习期.结论 SILC对

  1. COX-2和VEGF-C基因在乳腺良恶性病变中的表达研究%Expression of COX-2 and VEGF-C mRNA in benign and malignant breast diseases

    Institute of Scientific and Technical Information of China (English)

    肖锋; 顾春燕; 姚建国; 陈咏梅; 李民


    Objective To investigate the expression of COX-2 and VEGF-C mRNA in benign and malignant breast diseases and their association with breast tumorigenesis. Methods Tissue specimens were collected from 8 cases of accessory breasts, 15 cases of adenosis, 16 cases of fibroadenoma, 11 cases of ductal carcinoma in situ (DCIS) and 40 cases of invasive ductal carcinoma (IDC). Real-time PCR was used to detect the expression of COX-2 and VEGF-C mRNA. Results The accessory breasts were all negative for COX-2 mRNA expression, and weakly expressed VEGF-C. The expression of COX-2 and VEGF-C mRNA were increased significantly in adenosis and fibroadenoma tissues (P<0.05). In DCIS and IDC the expressions of COX-2 and VEGF-C mRNA were higher than those in adenosis and fibroadenoma (P < 0. 05). In IDC the expressions of COX-2 and VEGF-C mRNA were correlated with the histological grades. In DCIS and IDC, there was a strong positive correlation between COX-2 and VEGF-C mRNA expression (r = 0.82, P=0.002;r = 0. 89,P= 0.000, respectively). Conclusion The expressions of COX-2 and VEGF-C genes are increased in both benign and malignant breast diseases, and the expression levels in malignant breast diseases are higher than those in benign diseases. These results suggest that they might be important factors in the breast tumorigenesis, especially in breast carcinogenesis and tumor development.%目的 研究COX-2和VEGF-C mRNA在乳腺良恶性病变中的表达情况,探讨两者在乳腺肿瘤发生过程中的相互关系.方法 运用Real-time PCR方法对90例乳腺良恶性病变组织中COX-2和VEGF-C mRNA的表达进行检测.结果 8例副乳腺组织中,COX-2和VEGF-C mRNA不表达或低表达,15例腺病和16例纤维腺瘤中两者表达明显增加(P<0.05),11例DCIS中,两者均高表达,高于腺病和纤维腺瘤(P<0.05),40例IDC中,两者同样高表达,并且肿瘤级别越高,表达水平越高.在DCIS和IDC中,两者表达存在正相关关系(分别r=0.82,P=0.002;r=0

  2. Fistulas secondary to gynecological and obstetrical operations

    Directory of Open Access Journals (Sweden)

    Jakovljević Branislava N.


    Full Text Available The authors present urogenital and rectogenital fistulas treated at the Department of Obstetrics and Gynecology in Novi Sad in the period from 1976 to 1999. The study comprised 28 cases of fistula out of which 17 were vesicovaginal, 3 ureterovaginal, 1 vesicorecto vaginal and 7 recto vaginal. During the investigated period there were 182 Wertheim operations, 3864 total abdominal hysterectomies, 1160 vaginal hysterectomies and 7111 cesarean sections. The vesicovaginal fistulas were most frequent with the incidence of 0.33%, whereas the tocogenic fistulas did not occur. Urogenital fistulas secondary to radical hysterectomy are extremely rare thanks to the administered measures of prevention during the surgical procedure.

  3. CT findings of benign omental lesions following abdominal cancer surgery

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Sang Yun; Kim, Dong Won; Cho, Jin Han; Kwon, Hee Jin; Ha, Dong Ho; Oh, Jong Young [Diagnostic Radiology, Dong-A University College of Medicine, Busan (Korea, Republic of)


    The greater omentum is the largest peritoneal fold and can be the origin of primary pathologic conditions, as well as a boundary and conduit for disease processes. Most diseases involving the omentum manifest with nonspecific and overlapping features on computed tomography (CT). In particular, varying benign disease processes of traumatic, inflammatory, vascular, or systemic origin can occur in the omentum during the follow-up period after surgery for intra-abdominal malignancy. It can be challenging for radiologists due to various spectrum of CT findings. Thus, we reviewed the CT findings of various benign omental lesions after surgery for intra-abdominal malignancy.

  4. Benign Breast Problems and Conditions (United States)

    ... with a needle. Another example is a simple fibroadenoma . Simple fibroadenomas usually shrink or go away on their own. ... Cyst: A sac or pouch filled with fluid. Fibroadenoma: A type of solid, benign breast mass. Hormone: ...

  5. [The utility of metalloproteinases (MMPs) and their inhibitors (TIMPs) in diagnostics of gynecological malignancies]. (United States)

    Mieszało, Katarzyna; Ławicki, Sławomir; Szmitkowski, Maciej


    Metalloproteinases (MMPs) are a family of proteolytic enzymes, involved in the degradation of collagen and other extracellular matrix components. They play a very important role in many physiological processes, i.e. angiogenesis, hemostasis, cyclic changes in the endometrium, wounds healing, as well as in tumor growth and spreading. Already performed studies have shown significant increase in the expression of MMP-2 and MMP-9 in the most common gynecological cancer (cervix, endometrium, ovary) compared to normal tissue and benign lesions. In addition, the MMP-9 concentration correlated with the clinical stage and the presence of distant metastases. Moreover the level of MMP-2 was significantly associated with the degree of malignancy. MMP-7 may be helpful in the diagnosis of ovarian cancer and useful in estimating of lymph node metastasis presence in endometrial cancer. In the detection of cervical cancer it may be useful to evaluate the expression of MMP-11 and MMP-12 (absent in normal cells) and their increase according to the degree of tissue damage. The usefulness of metalloproteinases in the diagnosis of gynecological cancer still requires confirmation test. However, it appears that they will be valuable factors in diagnostic complement, especially in combination with conventional markers, i.e. CA 125, SCCAg or HE-4.

  6. Two Gynecological Cancer Screening Among 4171 Women From a University Community in Beijing%北京市某高校社区妇女宫颈癌和乳腺癌筛查结果分析

    Institute of Scientific and Technical Information of China (English)

    王笑灵; 杨志云


    目的 对北京市海淀区某高校社区4 171例妇女官颈癌和乳腺癌筛查结果进行分析,了解该地区妇女生殖健康状况,为今后制定妇女病防治措施提供依据.方法 对社区25~65岁妇女采用妇科常规检查和官颈液基脱落细胞学(TCT)检查的方法进行官颈癌筛查;对40 ~ 60岁妇女采用乳腺彩色多普勒超声的方法进行乳腺癌筛查.可疑病例转至定点医院进行复诊,并由专人负责随访.结果 参加官颈癌筛查4 171人,筛查率10.67%;妇科疾病患病率23.66%,其中子宫肌瘤患病率最高(11.00%);宫颈癌可疑转诊病例实访率98.53%.官颈上皮内瘤变患病率16.78/万;宫颈浸润癌患病率2.40/万.参加乳腺癌筛查3 110人,筛查率13.58%;乳腺疾病患病率28.01%,其中乳腺增生患病率最高,为14.05%;乳腺癌可疑转诊病例实访率为96.43%.乳腺癌患病率96.5/10万.结论 北京市某高校社区妇女官颈癌和乳腺癌筛查率均不高,定期进行筛查,对降低两癌的发病率和死亡率具有重要意义.%Objective By analyzing the data of cervical carcinoma and breast cancer among 4 171 women in a university community, Haidian district, Beijing city, to evaluate women's reproductive health status, and thus to provide scientific basis for prevention and treatment of gynecological disease. Methods Women aged 25 - 65 were screened for cervical cancer with gynecological examination and domestic thinprep cytologic test and women aged 40 - 60 were performed color Doppler ultrasonography for breast cancer screening. Results A total of 4 171 women received cervical cancer screening with a screening rate of 10. 67% ; the prevalence of gynecological benign disease was 23. 66% ; the morbidity of hysteromyoma, cervical intraepithelial neoplasia ( CIN) and invasive carcinoma of cervix was 11.00% (the highest) , 16. 78/104, 2. 40/104, respectively. There were 3110 women received breast cancer screening with a

  7. 北京市海淀区妇女两癌筛查情况分析%Analysis of two gynecological cancer screening among women in Haidian District of Beijing

    Institute of Scientific and Technical Information of China (English)

    胡美娜; 徐文; 周钰; 赵温


    Objective To investigate the status of reproductive health of women in Haidian District of Beijing, and to screen cervical cancer and breast cancer which threaten women's health seriously so as to provide some scientific foundation for effective prevention and cure of gynecological diseases. Methods Women with Haidian household registration and aged 25-65 were screened for cervical cancer with gynecological examination and domestic thinprep cytologic test, and for women aged 40-60 color Doppler ultrasonography was performed for breast cancer screening. Results There were 87 102 women receiving cervical cancer screening, and the screening rate was 15.18%. The prevalence rate of gynecological benign diseases, cervical intraepithelial neoplasis ( CIN ) and cervical cancer was 24.67%, 9.07/10 000,4.59/100 000, respectively. There were 68 114 women receiving breast cancer screening and the screening rate was 18.89%. The prevalence rate of breast benign diseases was 30.50%, and the breast cancer prevalence rate was 80.75/100 000. Conclusion Carrying ont two gynecological cancer screening is of great importance for reducing incidence and mortality rate of cervical cancer and breast cancer.Health education should be further strengthened and the screening system be improved so as to increase screening rates and protect women's reproductive health.%目的 了解北京市海淀区妇女生殖健康状况,筛查严重危害妇女健康的子宫颈癌和乳腺癌,为制定切实有效的妇女病防治措施提供依据.方法 采用妇科检查和国产液基薄层细胞学技术对海淀区户籍25-65岁妇女进行宫颈癌筛查,彩色多普勒超声对其中40-60岁的妇女进行乳腺癌筛查.结果 参加宫颈癌筛查的妇女有87 102人,筛查率为15.18%;妇科良性疾病患病率为24.67%,宫颈癌前病变患病率为9.07/万,宫颈癌患病率为4.59/10万.参加乳腺癌筛查的妇女有68 114例,筛查率为18.89%;乳腺良性疾病患病率为30

  8. 42 CFR 493.855 - Standard; Cytology: gynecologic examinations. (United States)


    ... 42 Public Health 5 2010-10-01 2010-10-01 false Standard; Cytology: gynecologic examinations. 493... Complexity, Or Any Combination of These Tests § 493.855 Standard; Cytology: gynecologic examinations. To... HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Participation...

  9. 甲状腺良性病变的18氟-脱氧葡萄糖PET/CT表现探讨%Analysis of 18 F-fluorodexyoxyglucose PET/CT in benign thyroid disease

    Institute of Scientific and Technical Information of China (English)

    吴江; 朱虹; 王新刚; 桂一; 刘伟彦; 卢光明


    目的 探讨甲状腺良性病变的18氟-脱氧葡萄糖(18 F fluorodexyoxyglucose,18F-FDG) PET/CT表现,以提高对该病变PET/CT影像的认识.方法 回顾性分析经手术病理明确诊断的24例甲状腺良性病变的18F-FDG PET/CT影像学资料,包括结节性甲状腺肿13例、甲状腺腺瘤10例、甲状腺局限性增生2例、桥本氏甲状腺炎4例、慢性甲状腺炎1例、亚急性甲状腺炎1例,其中10例患者甲状腺存在两个或多个病变.结果 结节性甲状腺肿的异常PET/CT征象包括①甲状腺低密度结节或密度弥漫性减低;②甲状腺肿大;③钙化;④甲状腺局灶性或弥漫性FDG代谢增高.13例结节性甲状腺肿4例未见PET/CT异常征象,仅2例FDG代谢增高(局灶性、弥漫性).甲状腺腺瘤的PET/CT异常征象包括①甲状腺低密度或略低密度结节;②囊变;③钙化;④甲状腺局灶性FDG代谢增高.10例甲状腺腺瘤仅2例局灶性FDG代谢增高.甲状腺局限性增生的PET/CT异常征象包括①甲状腺低密度结节;②甲状腺局灶性FDG代谢增高.2例甲状腺局限性增生1例局灶性FDG代谢增高.桥本氏甲状腺炎的PET/CT异常征象包括①甲状腺密度弥漫性减低;②甲状腺肿大;③甲状腺弥漫性FDG代谢增高.4例桥本氏甲状腺炎2例弥漫性FDG代谢增高.亚急性甲状腺炎和慢性甲状腺炎的PET/CT异常征象包括①甲状腺片状低密度灶;②甲状腺局灶性或弥漫性FDG代谢增高.结论 甲状腺良性病变可出现FDG摄取增高,但在结节性甲状腺肿、甲状腺腺瘤、甲状腺局限性增生出现比例低,而在桥本氏甲状腺炎等炎性病变比例相对较高;甲状腺弥漫性FDG摄取多提示良性病变,而局灶性FDG摄取需作进一步的鉴别.%Objective This study was designed to investigat the performance of positron emission tomography/computer tomography (PET/CT) with 18F-fluorodexyoxyglucose (18F-FDG) for benign thyroid disease. Methods

  10. Clinical study of nutritional status in elderly patients with benign respiratory disease%老年良性呼吸疾病住院患者营养状态的临床研究

    Institute of Scientific and Technical Information of China (English)

    奚桓; 崔红元; 朱明炜; 周雪娇; 杨鑫; 唐普贤; 许小毛; 韦军民


    目的 观察老年良性呼吸疾病住院患者的营养状态,评估其与临床结局的相关性.方法 前瞻性研究2012年4-5月年龄≥65岁的老年良性呼吸疾病住院患者,应用微型营养评定精(MNA-SF)法了解其营养状态,并观察临床结局,分析其相关性. 结果 本研究纳入符合入选标准患者1 269例,平均年龄(74.0±6.5)岁;体质指数(23.3±3.8)kg/m2;利手握力为(16.7±17.2)kg,随增龄下降;上臂围(25.7±3.7)cm,小腿围(32.3±3.8)cm;1 224例患者完成了MNA-SF,营养不良145例(11.8%)、营养不良风险411例(33.6%)、营养正常668例(54.6%);随增龄,营养不良和营养不良风险发生率均增加;其中营养不良者的病死率高、住院时间长和总住院费多(均P<0.01). 结论 老年良性呼吸疾病的住院患者营养不良和营养不良风险发生率较高,可能导致其临床结局恶化,应重视住院期间的营养状况评价.%Objective To investigate the nutritional status in elderly patients with benign respiratory disease and assess the correlation between nutritional status and clinical outcomes.Methods A prospective study of the elderly patients with benign respiratory disease,aged 65 years and over,from April 2012 to May 2012,was conducted.Mini-Nutritional Assessment-Short Form (MNA-SF) was used to assess the nutritional status.Associations between nutritional status and clinical outcomes were analyzed.Results A total of 1269 patients who met inclusion criteria were enrolled in this study,with a mean age of (74.0±6.5) years,a mean body mass index of(23.3±3.8) kg/m2,a mean grip strength of (16.7±17.2) kg,a mean upper arm circumference of(25.7±3.7) cm,a mean calf circumference of (32.3±3.8)cm.The grip strength declined with the increase of age.1 224 subjects completed the MNA-SF,among whom 145 cases (11.8%) suffered from malnutrition,411 cases (33.6%) were at a risk of malnutrition,668 cases (54.6%) were well nourished.The incidence of malnutrition

  11. 三种途径子宫切除术治疗良性子宫疾病的比较%Comparison of Three Different Approaches in Hysterectomy for Benign Uterine Diseases

    Institute of Scientific and Technical Information of China (English)

    舒珊荣; 罗新; 帅翰林; 范瑾; 陈瑞萍


    Objective To compare the characteristics of vaginal hysterectomy ( VH ) , laparoscopically assisted vaginal hysterectomy ( LAVH ) and total laparoscopic hysterectomy ( TLH ) for benign uterine diseases . Methods We retrospectively collected 155 cases of hysterectomy for benign uterine diseases in our hospital during March 2011 to November 2013.The surgical approach was chosen by patients .There were 60 cases of VH, 50 cases of LAVH, and 45 cases of TLH.The operating time, blood loss, consumption of analgesics , and the length of hospital stay were compared among the three groups . Results The median operation time was 65 min (range, 40-85 min) in the VH group, 90 min (range, 45-150 min) in the LAVH group, and 120 min (range, 80-180 min) in the TLH group, with statistically significant difference (χ2 =89.105, P=0.000).The blood loss had no significant difference between the VH group (208 ml, 155-241 ml) and the TLH group (183 ml, 159-220 ml), but significantly less than that in the LAVH group [359 ml (316-413 ml),χ2 =72.609, P=0.000].The consumption of analgesics in the LAVH group (2 doses, 1-5 doses) was significantly less than that in the VH group (4 doses, 1-8 doses) and the TLH group (5 doses, 3-8 doses) (χ2 =59.243, P=0.000).There was no significant difference in postoperative hospital stay among the three groups . Conclusion For benign uterine disease , VH and LAVH are preferential surgical procedures .%目的:比较阴式子宫切除( vaginal hysterectomy ,VH)、腹腔镜辅助阴式子宫切除( laparoscopically assisted vaginal hysterectomy,LAVH)以及腹腔镜子宫切除(total laparoscopic hysterectomy ,TLH)治疗子宫良性疾病的特点。方法回顾性分析我院2011年3月~2013年11月因子宫良性病变行全子宫切除155例资料,由患者选择手术方式,VH组60例,LAVH组50例,TLH组45例。比较3组手术时间、出血量、止痛药的使用以及住院时间的差异。

  12. Surgical of treating benign lung disease by compietly video-assisted thoracoscopic surgery (VATS) 56case%全电视胸腔镜手术治疗肺良性疾病56例

    Institute of Scientific and Technical Information of China (English)

    李勇; 程远建; 魏强


    目的 探讨电视胸腔镜手术(VATS)治疗肺部良性疾病的价值,手术安全性,以利于手术方式微创化.方法 我科自2009年9月~2010年11月,在全胸腔镜下手术治疗肺部良性疾病56例.全部病例均在全胸腔镜下完成,按照垒球场原则胸腔镜三切口,无中转开胸病例.结果 所有病例均为局部切除,手术时间35~145min,平均65min,术中出血10~600ml,平均60ml,1例患者术中出血600ml,术中输血400ml.5例胸腔粘连严重,予以仔细游离粘连后,手术完成,无中转开胸病例,1例术后出血,经过保守治疗得以控制,2例患者术后发生张力性气胸,增加引流管治疗后治愈,其中1例患者系糖尿病,术后第5天发生张力性气胸,继而发生胸腔感染,另1例术后第2天于哮喘后发生张力性气胸,呼吸机辅助呼吸2d后顺利脱机.平均住院时间6d,全组患者无围手术期死亡.结论 全胸腔镜手术治疗肺良性疾病创伤小,恢复快,切口美观,手术安全,有广泛的开展价值.%Objective To review the value and surgical safety of treating benign lung disease by video-assisted thoracoscopic surgery (VATS) ,for facilitating minimally invasive surgery.Methods 56 patients with benign lung disease were performed by VATS during Sep 2009 ~Nov 2010.All the cases were accomplished by VATS, making three incisions in accordance with the principles of Softball Field, no case was changed to thoracotomy.Results All the cases were local excision.The average time for surgery was 65min ranging from 35 ~ 145min and the average blood loss in surgery was 60ml ranging from 10 ~ 600ml.Only 1 patient was transfued 400ml of blood who lost 600ml during operation;5 cases with severe adhesiolysis of thoracic cavity, whose operations were accomplished after separating adhesions carefully and no one was changed to thoracotomy; 1 case of postoperative bleeding, controlled by conservative treatment; 2 patients of postoperative tension pneumothorax

  13. The Application of Self Management Program of Chronic Disease in Patients With Gynecological Malignant Tumor PICC Chemotherapy%妇科恶性肿瘤PICC化疗患者中慢性病自我管理项目的应用

    Institute of Scientific and Technical Information of China (English)



    目的分析妇科恶性肿瘤PICC化疗患者实施慢性病自我管理项目的效果。方法本次200例恶性肿瘤PICC化疗患者从我院妇科2013年1月~2015年12月抽选,按照患者的入院编号分成不同组:对照组行基础化的护理措施,研究组实施慢性病自我管理项目,评定预后效果。结果研究组的护理满意率为98.0%,高于对照组的82.0%,P<0.05,差异有统计学意义;研究组的自我效能、自我监测、治疗依从性、健康状态等评分高于对照组,P<0.05,差异有统计学意义。结论临床针对妇科恶性肿瘤PICC化疗患者实施慢性病自我管理项目作用显著,可提高自我管理能力、治疗依从性,预防并发症。%Objective To analyze the effect of PICC chemotherapy on patients with gynecological malignant tumor.Methods 200 cases of chemotherapy in patients with malignant PICC, from January 2013 to December 2015 in our hospital, according to the patient's admission number, which were divided into different groups, the control group foundation of care measures, the implementation of the study group of patients of chronic diseases self-management program, assess prognosis.Results The study group care satisfaction rate 98.0%, 82.0% higher than the control group,P<0.05, was difference had statistically significance, self-efficacy study groups, self-monitoring, treatment compliance, health status score was higher than the control group,P<0.05, was difference had statistically signiifcance.Conclusion The clinical treatment of gynecological malignant tumor PICC chemotherapy patients with chronic disease self management project effect signiifcantly, can improve self-management ability, treatment compliance, prevention of complications.

  14. Use of 5-alpha-reductase inhibitors did not increase the risk of cardiovascular diseases in patients with benign prostate hyperplasia: a five-year follow-up study.

    Directory of Open Access Journals (Sweden)

    Teng-Fu Hsieh

    Full Text Available This nationwide population-based study investigated the risk of cardiovascular diseases after 5-alpha-reductase inhibitor therapy for benign prostate hyperplasia (BPH using the National Health Insurance Research Database (NHIRD in Taiwan.In total, 1,486 adult patients newly diagnosed with BPH and who used 5-alpha-reductase inhibitors were recruited as the study cohort, along with 9,995 subjects who did not use 5-alpha-reductase inhibitors as a comparison cohort from 2003 to 2008. Each patient was monitored for 5 years, and those who subsequently had cardiovascular diseases were identified. A Cox proportional hazards model was used to compare the risk of cardiovascular diseases between the study and comparison cohorts after adjusting for possible confounding risk factors.The patients who received 5-alpha-reductase inhibitor therapy had a lower cumulative rate of cardiovascular diseases than those who did not receive 5-alpha-reductase inhibitor therapy during the 5-year follow-up period (8.4% vs. 11.2%, P=0.003. In subgroup analysis, the 5-year cardiovascular event hazard ratio (HR was lower among the patients older than 65 years with 91 to 365 cumulative defined daily dose (cDDD 5-alpha-reductase inhibitor use (HR=0.63, 95% confidence interval (CI 0.42 to 0.92; P=0.018, however there was no difference among the patients with 28 to 90 and more than 365 cDDD 5-alpha-reductase inhibitor use (HR=1.14, 95% CI 0.77 to 1.68; P=0.518 and HR=0.83, 95% CI 0.57 to 1.20; P=0.310, respectively.5-alpha-reductase inhibitor therapy did not increase the risk of cardiovascular events in the BPH patients in 5 years of follow-up. Further mechanistic research is needed.

  15. Benign metastasizing leiomyoma in triple location: lungs, parametria and appendix (United States)

    Raś, Renata; Książek, Mariusz; Skręt-Magierło, Joanna; Kąziołka, Wojciech; Fudali, Ludmiła; Filipowska, Justyna; Skręt, Andrzej


    Benign metastasizing leiomyoma (BML) usually are situated in one organ, most often in lungs. BML patients typically have a history of uterine leiomyoma treated with hysterectomy, myomectomy or subtotal hysterectomy. The aim of the study was to present the case of a 53-year-old woman with triple location in the lungs, parametria and appendix. She had undergone a myomectomy 26 years earlier. In 2015, she was admitted to the surgical department because of abdominal pain, whereupon a cholecystectomy was performed. CT scans showed pelvic mass with pulmonary metastasis. Upon discharge the patient was referred to the Gynecology Clinic, where a laparotomy was performed. The intraoperative findings were: 1) uterus with multiple leiomyomas, 2) four tumors in the parametria, 3) tumor connected to the appendix. A subtotal hysterectomy, with a bilateral salpingo-oophorectomy, removal of the tumors from the parametria and appendectomy was performed. Pathology confirmed the diagnosis based on morphology and immunohistochemical staining (strongly positive for estrogen receptors and SMA, while Ki67 was very low, below 1%). Upon postoperative recovery, the patient was referred to the Thoracic Surgery Department. During the thoracotomy, multiple nodes, surrounded by lung parenchyma, were revealed. Wedge resection was performed, for localized pulmonary lesions, and sent for pathological examination. The final pathological diagnosis was benign metastasizing leiomyomatosis. In conclusion, the triple location of BML could possibly be a result of a parallel different metastasizing mechanism, although it is impossible to exclude one mechanism, which may be the cause of the metastases in three locations. PMID:27582687

  16. Subspecialist training in surgical gynecological oncology in the nordic countries

    DEFF Research Database (Denmark)

    Antonsen, Sofie L; Avall-Lundqvist, Elisabeth; Salvesen, Helga B;


    To survey the centers that can provide subspecialty surgical training and education in gynecological oncology in the Nordic countries we developed an online questionnaire in cooperation with the Nordic Society of Gynecological Oncology. The link to the survey was mailed to 22 Scandinavian...... gynecological centers in charge of surgical treatment of cancer patients. Twenty centers (91%) participated. Four centers reported to be accredited European subspecialty training centers, a further six were interested in being accredited, and 11 centers were accredited by the respective National Board. Fourteen...... (74%) centers were interested in being listed for exchange of fellows. Our data show a large Nordic potential and interest in improving the gynecologic oncology standards and can be used to enhance the awareness of gynecological oncology training in Scandinavia and to facilitate the exchange...

  17. The representations of adolescents about gynecological consultation

    Directory of Open Access Journals (Sweden)

    Vera Lúcia de Oliveira Gomes


    Full Text Available Objective: To analyze the social representation of adolescents about gynecological consultation and the influence of those in searching for consultations. Method: Qualitative descriptive study based on the Social Representations Theory, conducted with 50 adolescents in their last year of middle school. The data was collected between April and May of 2010 by Evocations and a Focal Group. The software EVOC and contextual analysis were used in the data treatment. Results: The elements fear and constraint, constant in the central nucleus, can justify the low frequency of adolescents in consultations. The term embarrassment in the peripheral system reinforce current sociocultural norms, while prevention, associated with learning about sex and clarifying doubts, allows to envision an educative function. Obtained testimonies in the focal groups exemplify and reinforce those findings. Conclusion: For an effective health education, professionals, including nurses, need to clarify the youth individually and collectively about their rights to privacy, secrecy, in addition to focus the gynecological consultation as a promotion measure to sexual and reproductive health.

  18. Benign Liver Tumors (United States)

    ... Baby Boomers Get Tested Core Programs HE Webinar Disney 2014 5 Ways to Love Your Liver Liver ... Drive Away Liver Disease Liver Lowdown Aug 2013 Disney Marathon In The Field Healthy Foods Diet Recommendations ...

  19. Unilateral Pigmented Extramammary Paget's Disease of the Axilla Associated with a Benign Mole: A Case Study and a Review of Literature. (United States)

    Ladak, Aleem; Bramley, Maria; Titi, Sami


    Pigmented extramammary Paget's disease (PEMPD) is an uncommon intraepithelial adenocarcinoma and a rare variant of Paget's disease affecting skin that is rich in apocrine sweat glands such as the axilla, perianal region and vulva. It most commonly occurs in postmenopausal women and presents as a superficial pigmented scaly macule, mimicking a melanocytic lesion. The histological presentation is adenocarcinoma in situ with an increased number of melanocytes scattered between the Paget's cells. Therefore, PEMPD may be misdiagnosed as a melanocytic tumour both clinically and histologically. The tumour cells are usually positive for cytokeratin 7, epithelial membrane antigen, Cam 5.2, HER2, and mucicarmine stain while S100 and human melanoma black-45 highlight the processes of reactive dendritic cells. The association between Paget's cells and intratumoural reactive melanocytes is still unclear. We report our first case of PEMPD associated with an intradermal naevus involving the axilla in a 63-year-old woman.

  20. The WOMED model of benign thyroid disease: Acquired magnesium deficiency due to physical and psychological stressors relates to dysfunction of oxidative phosphorylation

    Directory of Open Access Journals (Sweden)

    Roy Moncayo


    Conclusions: We interpret the elevated thyroid vascularization and low magnesium levels as signs of an inflammatory process related to the musculoskeletal changes. Improvement of thyroid function and morphology can be achieved after correcting the influence of stressors together with the supplementation regime. We hypothesize that the central biochemical event in thyroid disease is that of an acquired, altered mitochondrial function due to deficiency of magnesium, selenium, and coenzyme Q10.

  1. Benign mixed tumor of the lacrimal sac

    Directory of Open Access Journals (Sweden)

    Jong-Suk Lee


    Full Text Available Neoplasms of the lacrimal drainage system are uncommon, but potentially life-threatening and are often difficult to diagnose. Among primary lacrimal sac tumors, benign mixed tumors are extremely rare. Histologically, benign mixed tumors have been classified as a type of benign epithelial tumor. Here we report a case of benign mixed tumor of the lacrimal sac.

  2. Pitfalls in diagnostic imaging and assessment of benign asbestos-related thoracic diseases; Fallstricke in der radiologischen Diagnostik und Begutachtung der benignen asbestbedingten Erkrankungen des Thorax

    Energy Technology Data Exchange (ETDEWEB)

    Rehbock, B. [Praxis fuer Diagnostische Radiologie am St.-Hedwig-Krankenhaus Berlin-Mitte, Berlin (Germany). Diagnostische Radiologie; Hofmann-Preiss, K. [Radiologische Gemeinschaftspraxis Erlangen (Germany). Radiologische Diagnostik; Kraus, T. [Universitaetsklinikum der RWTH Aachen (Germany). Inst. fuer Arbeits- und Sozialmedizin


    The recognition of asbestos-related diseases of the lung and/or pleura as an occupational disease is of psychosocial, medical and legal importance to the insured person. Radiological imaging is an essential part of the assessment and requires an increasingly high level of competence in the field of radiological diagnosis of pneumoconiosis in interdisciplinary collaboration with occupational medicine and pneumonology. The chest radiogram remains an integral part of basic diagnostic procedures in asbestos-related diseases of the lungs and/or pleura. Its importance lies in the detection of extended pleural changes as well as substantial fibrosis. The inherent low sensitivity and specificity of projection radiography is taken into account by the increasing use of multi-slice high resolution (HR) CT (in low dose technique). Radiological pitfalls in pleural plaque assessment with respect to plain chest X-ray concern all structures that superimpose on the pleural circumference, particularly the anatomical layers of the chest wall (extra-pleural fatty tissue, muscles, thoracic skeleton) as well as other pulmonary findings that can only be reliably assigned using CT. Even if state-of the-art CT is applied, asymmetries and abnormal expression of anatomical structures and variants (e.g. muscles and blood vessels) can lead to false-positive findings. The interstitial fibrosis of asbestosis, manifested as usual interstitial pneumonia (UIP) is non-pathognomonic for asbestosis. Therefore, parietal pleural thickening as a coincident finding to UIP is considered as being the main feature and a highly suggestive indicator of asbestosis in patients with a history of asbestos exposure. (orig.)

  3. Chemotherapy-induced neutropenia and febrile neutropenia in patients with gynecologic malignancy. (United States)

    Hashiguchi, Yasunori; Kasai, Mari; Fukuda, Takeshi; Ichimura, Tomoyuki; Yasui, Tomoyo; Sumi, Toshiyuki


    Chemotherapy-induced neutropenia is a common complication in cancer treatment. In this study, we investigated chemotherapy-induced neutropenia that was recently detected in all patients with gynecologic malignancy. Between January 2009 and December 2011, we examined cases of chemotherapy-induced neutropenia reported in our hospital. We analyzed the incidence and clinical features of chemotherapy-induced neutropenia and febrile neutropenia in patients with gynecologic malignancy. During the study period, we administered over 1614 infusions (29 regimens) to 291 patients. The median age of the patients was 60 years (range 24-84 years). Chemotherapy-induced neutropenia occurred in 147 (50.5%) patients over 378 (23.4%) chemotherapy cycles. Febrile neutropenia occurred in 20 (6.9%) patients over 25 (1.5%) cycles. The mean duration of neutropenia and fever was 3.6 days (range 1-12 days) and 3.4 days (range 1-9 days), respectively. The source of fever was unexplained by examination or cultures in 14 (56.0%) cycles. There were two cases of neutropenia-related death. Chemotherapy-induced neutropenia was associated with older age (over 70 years) (PFebrile neutropenia was associated with poor performance status (Pneutropenia nor febrile neutropenia was associated with bone marrow metastases or previous radiotherapy. By identifying risk factors for febrile neutropenia, such as performance status, no previous chemotherapy, disseminated disease, and distant metastatic disease, the safe management of chemotherapy-induced neutropenia may be possible in patients with gynecologic malignancy.

  4. Spatial contrast sensitivity in benign intracranial hypertension. (United States)

    Bulens, C; Meerwaldt, J D; Koudstaal, P J; Van der Wildt, G J


    Spatial Contrast Sensitivity (CS) was studied in 20 patients with benign intracranial hypertension (BIH). At presentation CS loss was found in 43% of the eyes, and impairment of visual acuity attributed to BIH in only 16%. Nine patients had blurred vision or visual obscurations, all of whom had abnormal CS. The clinical application of CS measurement in BIH for monitoring the progression or regression of the disease is illustrated by serial measurements in 11 patients. Progressive visual loss in longstanding papilloedema and improvement of visual function in subsiding papilloedema can occur without any change in Snellen acuity or visual field charting. PMID:3225588

  5. Spatial contrast sensitivity in benign intracranial hypertension. (United States)

    Bulens, C; Meerwaldt, J D; Koudstaal, P J; Van der Wildt, G J


    Spatial Contrast Sensitivity (CS) was studied in 20 patients with benign intracranial hypertension (BIH). At presentation CS loss was found in 43% of the eyes, and impairment of visual acuity attributed to BIH in only 16%. Nine patients had blurred vision or visual obscurations, all of whom had abnormal CS. The clinical application of CS measurement in BIH for monitoring the progression or regression of the disease is illustrated by serial measurements in 11 patients. Progressive visual loss in longstanding papilloedema and improvement of visual function in subsiding papilloedema can occur without any change in Snellen acuity or visual field charting.

  6. Benign symmetric lipomatosis of the knees

    Institute of Scientific and Technical Information of China (English)

    Zhiqiang Yin; Di Wu; Yixin Ge; Meihua Zhang; Zhigang Bi; Dan Luo


    Benign symmetric lipomatosis(BSL) is a rare disease characterized by the presence of multiple, symmetric and nonencapsulated fat masses in the face, neck and other areas. It is commonly seen in middle-aged Caucasian Mediterranean males, while its etiology is still not clear. The majority of the patients with BSL have a history of alcohol abuse and hepatopathy. BSL of the limbs is very rare. This article reports a unique case of a 60-year-old Chinese woman with involvement of the knees confirmed by the results of magnetic resonance imaging(MRI) and histopathology, which was not described previously in published literatures.

  7. Application value of mammography combined with ultrasound in benign and malignant breast diseases%乳腺钼钯结合超声在乳腺良、恶性疾病中的应用价值

    Institute of Scientific and Technical Information of China (English)

    张君华; 张连江; 陈才霞


    Objective:To explore the application value of mammography combined with ultrasound in benign and malignant breast diseases.Methods:The clinical data of 100 cases of patients with breast neoplasms were analyzed retrospectively and the imaging features of mammography and ultrasonography were analyzed.Results:The diagnostic accuracy of mammography was 75.9%,the diagnostic accuracy of ultrasonography was 83.1%,and the diagnostic accuracy of mammography combined with ultrasound was 92.3% .Conclusion:Mammography combined with ultrasound could improve the diagnostic accuracy for breast neoplasms effectively and had good clinical application effect.%目的:探讨乳腺钼钯结合超声在乳腺良、恶性疾病中的应用价值。方法:回顾性分析收治的乳腺肿瘤患者100例的临床资料,分析乳腺钼钯技术和超声的影像表现。结果:乳腺钼钯诊断准确率75.9%,超声诊断准确率83.1%,乳腺钼钯结合超声诊断准确率92.3%。结论:乳腺钼钯结合超声能有效提高对乳腺肿瘤检测的准确率,临床应用效果良好。

  8. 涎腺良性淋巴上皮病超声诊断与病理对照分析%Comparative analysis of ultrasonography and pathology diagnosis of benign lymphoepithelial disease of salivary gland

    Institute of Scientific and Technical Information of China (English)

    邱金鸾; 陈琴; 戴俊臣; 吴昊; 周青; 邓惋月


    Objective To summarize the ultrasonographic manifestation of the benign lymphoepithelial disease of salivary gland, in order to enhance the accuracy of ultrasound diagnosis .Methods The ultrasonographic images of 21 cases ( 40 lesions ) from January 2009 to May 2015 in People′s Hospital of Sichuan Hospital were retrospectively analyzed and compared with pathological findings.Results The ultrasonographic manifestations of the benign lymphoepithelial disease of salivary gland were classified into 4 types:(1)Increased diffuse type,6(15.0%) were in submandibular gland,ultrasound showed submaxillary gland enlargement, heterogeneous internal echo of the glands;pathology revealed lesions start from the centrilobular of the lobules,lymphocyte infiltration in the acinus,less lymph follicles,more normal glandular structures.(2)Multiple nodules type,22(55%),ultrasound showed bilateral glands inhomogeneous echo, glands within the multiple oval or irregular hypoechoic nodules,pathology showed that lesions start from the centrilobular of the lymph follicles, developed increasingly, enlarged gradually, normal glandular structures reduced,the acinar lesions parts were destroyed and were replaced by intensive lymphocytes and histiocytes, lymphoid follicles and lymphocyte widely existed in epithelial myoepithelial island.( 3 ) Mass type, 6 (15.0%) ,ultrasound showed single or multiple masses,the masses were low echo or mixed echo;pathology showed lymphocytic infiltration, alveolar destruction, as a substitute for lymphocytes and tissue cells, and formed a solid epithelial clumps.In addition,intralobular duct expanded to be cyst cavity.(4) Sclerotic and atrophic type,6(15.0%),ultrasound showed the entire gland volume reduced,internal echo enhancement, uneven echo, and visible bands of strong echo;pathology showed glands were infiltrated by diffused lymphocyte,acinus almost disappeared, remnants of the gland ducts and myoepithelial island were visible sometimes.Conclusion The

  9. DNA Cytometry and Nuclear Morphometry in Ovarian Benign, Borderline and Malignant Tumors (United States)

    el Din, Amina A. Gamal; Badawi, Manal A.; Aal, Shereen E. Abdel; Ibrahim, Nihad A.; Morsy, Fatma A.; Shaffie, Nermeen M.


    BACKDROUND: Ovarian carcinoma is a leading cause of death in gynecological malignancy. Ovarian surface epithelial serous and mucinous tumours are classified as benign, borderline, and malignant. The identification of borderline tumours most likely to act aggressively remains an important clinical issue. AIM: This work aimed to study DNA ploidy and nuclear area in ovarian serous and mucinous; benign, borderline and malignant tumours. MATERIAL AND METHODS: This study included forty ovarian (23 serous and 17 mucinous) tumours. Paraffin blocks were sectioned; stained with haematoxylin and eosin for histopathologic and morphometric studies and with blue feulgen for DNA analysis. RESULTS: All four serous and six out of nine mucinous benign tumours were diploid. All eight serous and five mucinous malignant tumours were aneuploid. Nine of eleven (81.8%) serous and all three mucinous borderline tumours were aneuploid. There were highly significant differences in mean aneuploid cells percentage between serous benign (1.5%), borderline (45.6%) and malignant (74.5%) (p = 0.0001) and between mucinous benign (13.2%) and both borderline (63.7%) and malignant (68.4%) groups (p = 0.0001). There were significant differences in nuclear area between serous benign (26.191%), borderline (45.619%) and malignant (67.634 %) and a significant positive correlation between mean percentage aneuploid value and mean nuclear area in all serous and mucinous groups. CONCLUSION: We suggest that DNA ploidy and nuclear area combined, may be adjuncts to histopathology; in ovarian serous and mucinous benign, borderline and malignant neoplasms; identifying the aggressive borderline tumours. PMID:27275284

  10. Drug utilization study of gynecology OPD: In a tertiary care hospital.

    Directory of Open Access Journals (Sweden)

    Baig MS, Bagle TR,Gadappa SN, Deshpande Sonali, Doifode SM


    Full Text Available Background: The treatment of diseases by use of essential medicines, prescribed by generic names, has been emphasized by WHO and National Health Policy of India. Drugs used in gynaecology are one of the top selling drugs in India; however they are least studied with respect to drug utilization. Thus present study was undertaken to analyze drug utilization pattern of gynecology OPD in a tertiary care hospital. Materials and Methods: A retrospective, cross sectional, observational study of prescriptions in Gynecology OPD. Data was obtained from an electronic medical record database of patients that attended Gynecology OPD during the study period. Prescription records of patients were screened as per inclusion and exclusion criteria and 300 prescriptions were randomly selected by Openepi software. Patient related and drug related information was collected on a customized data collection sheet. Results: The mean age of patients was 30.19+9.83 years and common age of presentation was >18-30 years. In infective cases, vaginal discharge (10.33% was common, and in non-infective cases, menstrual disorders (24% were common. The average number of drugs per prescription was 3.47+1.53. In drug category, minerals (30.94% were most commonly prescribed, followed by antimicrobials (24.98%, and NSAIDs (13.37%. Polypharmacy was observed in 96.33% of the prescriptions. Conclusion: It is only by drug utilization studies that burden of diseases and corresponding utilization of drugs in gynecology can be measured. In our study majority of the drugs prescribed were generic which were from the essential medical list NLEM and WHO.

  11. Ultrasound Image Discrimination between Benign and Malignant Adnexal Masses Based on a Neural Network Approach. (United States)

    Aramendía-Vidaurreta, Verónica; Cabeza, Rafael; Villanueva, Arantxa; Navallas, Javier; Alcázar, Juan Luis


    The discrimination between benign and malignant adnexal masses in ultrasound images represents one of the most challenging problems in gynecologic practice. In the study described here, a new method for automatic discrimination of adnexal masses based on a neural networks approach was tested. The proposed method first calculates seven different types of characteristics (local binary pattern, fractal dimension, entropy, invariant moments, gray level co-occurrence matrix, law texture energy and Gabor wavelet) from ultrasound images of the ovary, from which several features are extracted and collected together with the clinical patient age. The proposed technique was validated using 106 benign and 39 malignant images obtained from 145 patients, corresponding to its probability of appearance in general population. On evaluation of the classifier, an accuracy of 98.78%, sensitivity of 98.50%, specificity of 98.90% and area under the curve of 0.997 were calculated.

  12. Retreatment with bevacizumab in patients with gynecologic malignancy is associated with clinical response and does not increase morbidity

    Directory of Open Access Journals (Sweden)

    Laskey RA


    Full Text Available Robin A Laskey,1 Scott D Richard,2 Ashlee L Smith,1 Jeff F Lin,1 Tiffany L Beck,3 Jamie L Lesnock,1 Joseph L Kelley 3rd,1 Alexander B Olawaiye,1 Paniti Sukumvanich,1 Thomas C Krivak4 1Division of Gynecologic Oncology, Magee-Womens Hospital of UPMC, Pittsburgh, 2Division of Gynecologic Oncology, Drexel University College of Medicine/Hahnemann University Hospital, Philadelphia, 3Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Hospital of UPMC, Pittsburgh, 4Division of Gynecologic Oncology, Western Pennsylvania Hospital, Pittsburgh, PA, USA Purpose: Bevacizumab (Bev is associated with improved progression-free survival in advanced epithelial ovarian cancer. The use of Bev in patients with gynecologic malignancy is increasing; however, little is known about cumulative toxicity and response in patients retreated with Bev. Our goal was to determine cumulative side effects and response in patients retreated with Bev. Patients and methods: Women with recurrent gynecologic malignancy treated with Bev between January 2007 and March 2012 at a single institution were identified, including a subset who received Bev in a subsequent regimen. The primary outcome was Bev-associated toxicity, and the secondary outcome was response. Results: Of 83 patients that received Bev for recurrent disease, 23 were retreated with Bev and four received Bev maintenance. Three patients (13% developed grade 3 or 4 hypertension; all had a history of chronic hypertension. One (4.3% patient developed grade 3 proteinuria, and one (4.3% developed an enterovaginal fistula. Four patients discontinued Bev secondary to toxicity. Toxicity was not related to the cumulative number of cycles. Twenty-six percent of patients responded to Bev retreatment. On univariate analysis, there was a significant (P=0.003 overall survival advantage when the Bev-free interval was >9 months (95% confidence interval [CI] 4.9–43.7 compared to ≤9 months (95% CI 2.1–11.5, 24

  13. Complications in gynecological minimal-access oncosurgery. (United States)

    Becker, Sven; De Wilde, Rudy Leon


    Complications are the limiting factors of all surgeries. More than performing the actual surgery, learning how to avoid complications before, during, and after surgery is the most important task of every surgeon. Severe complications can lead to patient death. Complications such as ureterovaginal fistulas, resulting from <2 s of inattentive preparation, can lead to years of hardship, suffering, accusation, and litigation. Excellent surgery is about performing the right surgery for the right patient without any complications. Minimally invasive surgery in complex cases is technically challenging. This article details the major causes of complications in laparoscopy for the gynecologic cancer patient and present strategies for prevention, early detection, and intra- and postoperative management.

  14. A prospective study of breast anthropomorphic measurements, volume and ptosis in 605 Asian patients with breast cancer or benign breast disease (United States)

    Mo, Miao; Chen, Jia-jian; Yang, Ben-long; Huang, Xiao-yan; Wu, Jiong


    Objectives The current study aims to summarize breast anthropomorphic measurement features in Chinese patients with breast diseases and to investigate their potential correlations with demographic factors. Materials and methods Fifteen breast anthropomorphic parameters of 605 Chinese female patients were collected prospectively. Breast ptosis status was scaled by two methods and breast volume was calculated according to a modified formula of BREAST-V. Results Among 1210 breasts, the average breast volume was 340.0±109.1 ml (91.8–919.2 ml). The distance from the nipple to the inframammary fold was 7.5±1.6 cm in the standing position. The width of the breast base was 14.3±1.4 cm (8.5–23.5 cm). The incidence of breast ptosis was 22.8% (274/1204), of which 37 (23.5%) and 79 (31.7%) women had severe ptosis assessed by different criteria. Increased height (OR[odds ratio] = 1.500, Pcosmetic and reconstructive breast surgery decisions. Post-menopausal status, increased BMI, and breastfeeding for more than six months were independent risk factors for both increased breast volume and breast ptosis. PMID:28192525

  15. Environmentally Benign Stab Detonators

    Energy Technology Data Exchange (ETDEWEB)

    Gash, A E


    The coupling of energetic metallic multilayers (a.k.a. flash metal) with energetic sol-gel synthesis and processing is an entirely new approach to forming energetic devices for several DoD and DOE needs. They are also practical and commercially viable manufacturing techniques. Improved occupational safety and health, performance, reliability, reproducibility, and environmentally acceptable processing can be achieved using these methodologies and materials. The development and fielding of this technology will enhance mission readiness and reduce the costs, environmental risks and the necessity of resolving environmental concerns related to maintaining military readiness while simultaneously enhancing safety and health. Without sacrificing current performance, we will formulate new impact initiated device (IID) compositions to replace materials from the current composition that pose significant environmental, health, and safety problems associated with functions such as synthesis, material receipt, storage, handling, processing into the composition, reaction products from testing, and safe disposal. To do this, we will advance the use of nanocomposite preparation via the use of multilayer flash metal and sol-gel technologies and apply it to new small IIDs. This work will also serve to demonstrate that these technologies and resultant materials are relevant and practical to a variety of energetic needs of DoD and DOE. The goal will be to produce an IID whose composition is acceptable by OSHA, EPA, the Clean Air Act, Clean Water Act, Resource Recovery Act, etc. standards, without sacrificing current performance. The development of environmentally benign stab detonators and igniters will result in the removal of hazardous and toxic components associated with their manufacturing, handling, and use. This will lead to improved worker safety during manufacturing as well as reduced exposure of Service personnel during their storage and or use in operations. The

  16. Design of environmentally benign processes

    DEFF Research Database (Denmark)

    Hostrup, Martin; Harper, Peter Mathias; Gani, Rafiqul


    This paper presents a hybrid method for design of environmentally benign processes. The hybrid method integrates mathematical modelling with heuristic approaches to solving the optimisation problems related to separation process synthesis and solvent design and selection. A structured method...... of solution, which employs thermodynamic insights to reduce the complexity and size of the mathematical problem by eliminating redundant alternatives, has been developed for the hybrid method. Separation process synthesis and design problems related to the removal of a chemical species from process streams...... mixture and the second example involves the determination of environmentally benign substitute solvents for removal of a chemical species from wastewater. (C) 1999 Elsevier Science Ltd. All rights reserved....

  17. Multicystic Benign Mesothelioma Complicating Pregnancy. (United States)

    Tamhankar, V A


    Multicystic benign mesothelioma (MBM) is a rare peritoneal pathology typically affecting women in reproductive age. Though MBM is considered benign, these lesions are prone to recurrence and their growth could be modulated by the presence of oestrogen receptors. Acute presentation of MBM is still very rare in pregnancy and management options are not established. We describe a case of MBM presenting in early pregnancy with acute pain. This was successfully treated with surgical resection. Pregnancy continued uneventfully to term and no evidence of recurrent MBM was found at Caesarean section.

  18. Multicystic Benign Mesothelioma Complicating Pregnancy

    Directory of Open Access Journals (Sweden)

    V. A. Tamhankar


    Full Text Available Multicystic benign mesothelioma (MBM is a rare peritoneal pathology typically affecting women in reproductive age. Though MBM is considered benign, these lesions are prone to recurrence and their growth could be modulated by the presence of oestrogen receptors. Acute presentation of MBM is still very rare in pregnancy and management options are not established. We describe a case of MBM presenting in early pregnancy with acute pain. This was successfully treated with surgical resection. Pregnancy continued uneventfully to term and no evidence of recurrent MBM was found at Caesarean section.

  19. Is "Benign Childhood Epilepsy with Centrotemporal Spikes” Always Benign?

    Directory of Open Access Journals (Sweden)

    Muhammad SAEED


    Full Text Available How to Cite This Article: Saeed M, Azam M, Shabbir N, Qamar ShA. Is "Benign Childhood Epilepsy with Centrotemporal Spikes" Always Benign? Iran J Child Neurol. 2014 Summer;8(3: 39-45.AbstractObjectiveTo determine the prevalence of associated behavioral problems and prognosis with Benign Childhood Epilepsy with CentroTemporal Spikes (BCECTS.Descriptive, Cross Sectional study that was conducted from October 2009 to April 2013 in the Department of Pediatric Neurology, the Children’s Hospital Taif, KSA.Material & MethodsThis study was conducted after approval from the Ethics Committee of the Children’s Hospital Taif, Saudi Arabia. Thirty-two patients from the age of 3 to 10 years old were recruited from the pediatric neurology clinic over a period of 4 years. All the patients were selected based on history, EEGs, and neuropsychological and neurological examinations.EEGs were performed for all the patients while in awake and sleep states. Those who had centrotemporal discharges were included in the study. All the patients also underwent a brain MRI. Only two patients had mild cortical atrophy but developmentally they were normal.ResultsIn our study, prevalence of BRE is 32/430 (7.44%. Among the 32 cases, 24 were male and eight were female. Six cases out of 32 indicated a family history of BRE. Twenty-eight cases had unilateral right sided centrotemporal discharges and four had bilateral discharges.ConclusionIt is possible that for BECTS, a high number of seizures might play an important role in the development of mild cognitive impairment and/or behavior disturbances.ReferencesBradley WG, Daroff RB, Fenichel JM, Jahrovic J. Neurology of clinical practice. 5th Ed. 2009: pp. 1953-1990.Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, Cross H, Van Emde Boas M, et al: Revised terminology and concepts for organization of seizures and epilepsies: Report of the ILAE Commission on Classification and Terminology, 2005–2009. Epilepsia. 2010

  20. [Benign recurring aseptic meningitis. What requires our attention?]. (United States)

    Kruis, T; Kredel, L; Nassir, M; Godbersen, M; Schneider, T


    Benign recurrent aseptic meningitis (BRAM) or Mollaret's meningitis is a rare disease characterized by recurrent episodes of aseptic meningitis followed by spontaneous recovery. Disease courses over several years have been reported. In most cases, BRAM is caused by HSV-2, less frequently by other viruses or autoimmune diseases. In up to 10 %, the aetiology remains unclear. We present a case of idiopathic BRAM and discuss clinical findings, diagnosis and therapeutic options of this rare illness.

  1. Clinical Analysis of Benign Paroxysmal Positional Vertigo Secondary to Otogenic Diseases%继发于耳源性疾病的良性阵发性位置性眩晕的临床分析

    Institute of Scientific and Technical Information of China (English)

    滕锦楠; 纪洋洋; 徐林根


    Objective:To analyze the clinical characteristics of benign paroxysmal positional vertigo (BPPV) secondary to otogenic diseases. Methods: The clinical data of 67 patients with otogenic BPPV admitted to department of otolaryngology in Third People's Hospital of Yancheng City from January 2010 to June 2012 was retrospectively analyzed. The outcome of patients with otogenic BPPV was compared with the idiopathic BPPV. All of the patients were treated with the canalith repositioning procedure (CRP). Results: Among the 67 patients, 22 cases were secondary to sudden deafness, 17 cases were secondary to labyrinthitis, 13 cases were secondary to Meniere's disease, 8 cases were secondary to operations on the middle or inner ear, and 7 cases were secondary to vestibular neuronitis. There were no statistical difference in age, gender, lesion location in semicircular canal between otogenic BPPV patients and idiopathic BPPV patients (P>0. 05). The patients secondary to sudden deafness were significantly older than idiopathic BPPV patients (P<0. 001), while CRP times of BPPV patients secondary to Meniere's disease was significantly more than that of idiopathic BPPV patients (P = 0. 003). Conclusions: The causes of otogenic BPPV is diverse, and prognosis of the otogenic BPPV is associated with the causes.%目的:探讨继发于耳源性疾病的良性阵发性位置性眩晕(benign paroxysmal positional vertigo,BPPV)的临床特征.方法:回顾分析盐城市第三人民医院耳鼻咽喉科2010年1月 2012年6月收治的67例继发于耳源性疾病的BPPV(耳源性BPPV)患者的临床资料,并与同期119例原发性BPPV患者对照比较,分析耳源性BPPV的临床特点、病因及预后.所有患者均采用管石复位法治疗.结果:耳源性BPPV患者中包括突发性耳聋22例(32.8%),迷路炎17例(25.4%),梅尼埃病13例(19.4%),中-内耳手术后8例(11.9%),前庭神经元炎7例(10.4%).耳源性BPPV与原发性BPPV两组患者年龄、性别、半

  2. Prevalence of autoimmune pancreatitis and other benign disorders in pancreatoduodenectomy for presumed malignancy of the pancreatic head

    NARCIS (Netherlands)

    M. van Heerde (Marc); K. Biermann (Katharina); P.E. Zondervan (Pieter); G. Kazemier (Geert); C.H.J. van Eijck (Casper); C.J. Pek (Chulja); E.J. Kuipers (Ernst); H.R. van Buuren (Henk)


    textabstractBackground: Occasionally patients undergoing resection for presumed malignancy of the pancreatic head are diagnosed postoperatively with benign disease. Autoimmune pancreatitis (AIP) is a rare disease that mimics pancreatic cancer. We aimed to determine the prevalence of benign disease a

  3. Benign concentric annular macular dystrophy

    Directory of Open Access Journals (Sweden)

    Luísa Salles de Moura Mendonça


    Full Text Available The purpose of the authors is to show clinical findings of a patient with benign concentric annular macular dystrophy, which is an unusual condition, and part of the "bull’s eye" maculopathy differential diagnosis. An ophthalmologic examination with color perception, fluorescein angiography, and ocular electrophysiology was performed.

  4. [110 years--University Obstetrics and Gynecology Hospital "Maichin dom"]. (United States)

    Zlatkov, V


    The first specialized Obstetrics and Gynecology Hospital in Bulgaria was founded based on the idea of Queen Maria Luisa (1883). Construction began in 1896 and the official opening of the hospital took place on November 19, 1903. What is unique about the University Obstetrics and Gynecology Hospital "Maichin dom" is above all the fact that the Bulgarian school of obstetrics and gynecology was founded within its institution. Currently, the hospital has nearly 400 beds and 600 employees who work at nine clinics and six laboratories, covering the entire spectrum of obstetric and gynecological activities. Its leading specialists still continue to embody the highest level of professionalism and dedication. The future development of the hospital is chiefly associated with the renovation of facilities, resources and equipment and with the enhancement of the professional competence of the staff and of the quality of hospital products to improve the health and satisfaction of the patients.

  5. North American Society for Pediatric and Adolescent Gynecology (United States)

    ... Education Short Curriculum Resident Education Long Curriculum PAGWebEd E-Learning Center Other Resources NASPAG Publications NASPAG Branded Publications Journal of Pediatric and Adolescent Gynecology NASPAG Newsletters Career ...

  6. 3T MR-Guided Brachytherapy for Gynecologic Malignancies

    CERN Document Server

    Kapur, Tina; Damato, Antonio; Schmidt, Ehud J; Viswanathan, Akila N; 10.1016/j.mri.2012.06.003


    Gynecologic malignancies are a leading cause of death in women worldwide. Standard treatment for many primary and recurrent gynecologic cancer cases includes a combination of external beam radiation, followed by brachytherapy. Magnetic Resonance Imaging (MRI) is benefitial in diagnostic evaluation, in mapping the tumor location to tailor radiation dose, and in monitoring the tumor response to treatment. Initial studies of MR-guidance in gynecologic brachtherapy demonstrate the ability to optimize tumor coverage and reduce radiation dose to normal tissues, resulting in improved outcomes for patients. In this article we describe a methodology to aid applicator placement and treatment planning for 3 Tesla (3T) MR-guided brachytherapy that was developed specifically for gynecologic cancers. This has been used in 18 cases to date in the Advanced Multimodality Image Guided Operating suite at Brigham and Women's Hospital. It is comprised of state of the art methods for MR imaging, image analysis, and treatment plann...

  7. Surgical Coagulator With Carbon Dioxide Laser For Gynecology (United States)

    Wolinski, Wieslaw; Kazmirowski, Antoni; Korobowicz, Witold; Olborski, Zbigniew


    The technical data and parameters of the CO2 surgical laser for gynecology are given. Coagulator was designed and constructed in Institute of Microelectronics and Optoelectronics Warsaw Technical University.

  8. Early prediction of a benign course of multiple sclerosis on clinical grounds : a systematic review

    NARCIS (Netherlands)

    Ramsaransing, G; Maurits, N; Zwanikken, C; De Keyser, J


    Background. There is growing consensus that neurologists should consider disease-modifying therapies early in multiple sclerosis (MS). However there is a subgroup with a natural benign course, in which treatment could be postponed. We sought to determine the frequency of benign MS and early clinical

  9. Levodopa-Responsive Benign Tremulous Parkinsonism

    Directory of Open Access Journals (Sweden)

    Osamu Kano


    Full Text Available Background: Benign tremulous parkinsonism (BTP is a tremor dominant syndrome characterized by mild, levodopa-resistant parkinsonism with limited disability or progression. Case Presentation: A 56-year-old woman presented with a 2-year history of tremor. Neurological examination revealed right-hand rest tremor and slow finger tapping with decreased amplitude; however, we did not observe posture tremor, rigidity, bradykinesia, or posture disability. She was diagnosed with Parkinson's disease (PD and received levodopa/carbidopa, effectively treating her rest tremor. At the age of 61 years, reoccurrence of the rest tremor was successfully treated again with levodopa/carbidopa and selegiline. Approximately 11 years have passed since symptom onset and the patient shows no further disease progression. Conclusion: This case broadens the characterization of BTP to include levodopa-responsive PD.

  10. 改良小切口甲状腺次全切术在甲状腺良性疾病中的应用%Application of Improved Mini-Incision Subtotal Thyroidectomy in the Be-nign Thyroid Disease

    Institute of Scientific and Technical Information of China (English)



    Objective To study the clinical effect of improved mini-incision subtotal thyroidectomy in the treatment of benign thy-roid disease. Methods 80 patients with benign thyroid disease treated from June 2013 to May 2014 in our hospital were selected and randomly divided into control group and experimental group, 40 cases in each group. The experimental group adopted the im-proved mini-incision subtotal thyroidectomy and control group adopted the conventional subtotal thyroidectomy. The indicators in-cluding hospitalization time, size of incision, intraoperative blood loss, operation time, paresthesia time of neck skin etc, as well as the recurrences and incidences of complications of the two groups were compared. Results The indicators like hospitalization time, size of incision, intraoperative blood loss, operation time, paresthesia time of neck skin of experimental group were significantly better than those of control group, P<0.05;the recurrence rate and incidence rate of complications of experimental group was signif-icantly lower than that of control group, P<0.05. Conclusion The improved mini-incision subtotal thyroidectomy can reduce the postoperative recurrences and incidences of complications, promote the patient's recovery and has fewer impacts on the normal cervical movements. It is worthy of clinical promotion.%目的:探析甲状腺良性病变进行改良小切口甲状腺次全切术疗法的临床效果。方法随机选取该院2013年6月-2014年5月甲状腺良性病变病人80例,根据随机数字表法分为对照组、实验组,每组40例,实验组进行改良小切口甲状腺次全切术疗法,对照组进行常规甲状腺全切术疗法,比较两组的住院时间、切口大小、术中出血量、手术时间、颈部皮肤感觉异常时间等指标;比较两组的复发情况和并发症发生情况。结果实验组的住院时间、切口大小、术中出血量、手术时间、颈部皮肤感染异常时间等指标显

  11. Benign Pancreatic Duct Strictures: Medical and Endoscopic Therapy

    Directory of Open Access Journals (Sweden)

    JE Geenen


    Full Text Available Pancreatic duct strictures usually reflect underlying pancreatic disease and are likely caused by one or more of the following: acute or chronic pancreatitis, benign or malignant pancreatic neoplasm, pseudocyst and trauma. The characteristics of pancreatic strictures are identified, and medical and endoscopic therapy options are reviewed.

  12. Current status of surgery for benign disorders of the esophagus

    NARCIS (Netherlands)

    Draaisma, Werner Adriaan


    This thesis aimed at exploring new techniques for the surgical treatment of benign disorders of the esophagus. Specifically, studies were performed on surgery for gastroesophageal reflux disease and large (type II-IV) hiatal hernia. The chapters presented in this thesis involve studies that have bee

  13. Obesity: internal medicine, obstetric and gynecological problems related to overweight. (United States)

    Grio, R; Porpiglia, M


    Obesity is the major nutritional problem affecting industrialised society. According to a recent ISTAT survey, 41% of men and 19% of women in the Italian population suffer from obesity. Obesity is a complex pathological entity with a multiform and often indeterminable etiology. Studies of natural and adopted children and twins suggest that a clear hereditary, constitutional predisposing factor is present in obesity which interacts with environmental conditions. The genetic factor is also suggested by the statistical finding that if neither parent is obese, then only 7-10% of their children will be obese, whereas if one parent is obese, 40-50% of children will probably become obese, and if both parents are obese as many as 70-80% of children will be obese. The risks related to obesity can be broadly categorised as mechanical and metabolic. The former include arthrosis, osteoporosis, degenerative diseases affecting the joints and bone matrix, muscular hypotrophy and respiratory deficits. The major metabolic risks include hypercholesterolemia, altered glycoregulation and hyperuricemia. From an obstetric point of view, apart from the fact that obesity is often associated with sterility, excess weight can often lead to sometimes dramatic complications during pregnancy, involving major risks for both mother and fetus. From a gynecological point of view the links between obesity, tumours and menopause are well known.

  14. Hereditary benign telangiectasia without family history in China

    Institute of Scientific and Technical Information of China (English)

    CAI Lin; SUN Qing-miao; ZANG Dong-jie; ZHANG Jian-zhong


    A case of hereditary benign telangiectasia without family history was reported. A 39-year-old woman presented with small and tiny telangiectases on the face, neck, upper trunk and forearms at birth. The numbers and sizes of the lesions increased gradually and she had no hemorrhagic diathesis and systemic diseases. No similar patients were found in her family. Upon physical examination, telangiectases were found on the face, neck, upper trunk and forearms; and a telangiectatic erythema was found on the right forearm 25 mm ×40 mm in size. Histopathology examination showed a normal epidermis and dilation of the capillaries at upper dermis. Hereditary benign telangiectasia without family history was diagnosed.

  15. Single benign metastasising leiomyoma of an inguinal lymph node. (United States)

    Laban, Kamil G; Tobon-Morales, Roberto E; Hodge, Janice A L; Schreuder, Henk W R


    Benign metastasising leiomyoma (BML) is a rare benign disease associated with uterine leiomyoma and history of uterine surgery. It most frequently occurs in premenopausal woman, with a pulmonary localisation, and consisting of multiple nodules. We present an uncommon case of a 69-year-old woman with a single BML of an inguinal lymph node. CT scans of thorax and abdomen excluded other metastasis localisation. The patient was cured with surgical excision of the mass. Lymph node involvement has been reported incidentally in BML literature. Lymphangitic spread can be considered a possible mechanism of BML metastasis.

  16. New radiation techniques in gynecological cancer. (United States)

    Ahamad, A; Jhingran, A


    Radiation therapy has been a major therapeutic modality for eradicating malignant tumors over the past century. In fact, it was not long after the discovery of radium that the first woman with cervical cancer underwent intracavitary brachytherapy. Progress in the way that this cytotoxic agent is manipulated and delivered has seen an explosive growth over the past two decades with technological developments in physics, computing capabilities, and imaging. Although radiation oncologists are educated in and familiar with the wealth of new revolutionary techniques, it is not easy for other key members of the team to keep up with the rapid progress and its significance. However, to fully exploit these enormous gains and to communicate effectively, medical and gynecological oncologists are expected to be aware of state-of-the-art radiation oncology. Here, we elucidate and illustrate contemporary techniques in radiation oncology, with particular attention paid to the external beam radiotherapy used for adjuvant and primary definitive management of malignancies of the female pelvis.

  17. Chlamydia trachomatis cervicitis in gynecologic outpatients. (United States)

    Ripa, K T; Svensson, L; Mårdh, P A; Weström, L


    Symptoms suggestive of a lower genital tract infection (LGTI) are common complaints in women who consult gynecologists. Sexually transmitted microorganisms, such as Chlamydia trachomatis. Neisseria gonorrhoeae, and Trichomonas vaginalis, are responsible for a substantial proportion of LGTI. This study was performed to establish the frequency of LGTI caused by C trachomatis in women attending a gynecologic outpatient clinic. Of 170 women with LGTI, 32.9% harbored one or more of these organisms: C trachomatis was found in 19.3%, N gonorrhoeae in 4.7%, and T vaginalis in 25.9%. The results of the isolation studies were correlated with clinical signs and symptoms. In women under 25 years of age, chlamydial cervicitis was found significantly more often in users of oral contraceptives than in nonusers. In women not taking such drugs, cervical erosion was found more often in Chlamydia-positive than Chlamydia-negative women. Since clinical examination failed to reveal any characteristic signs in cases of chlamydial infection, it was not possible to distinguish a chlamydial from a gonococcal infection. This study also reports the successful treatment of 15 women affected by chlamydial cervicitis with doxycycline or trimethoprim sulphamethoxazole.

  18. Controlled Prospective Longitudinal Study of Women with Cancer: I. Sexual Functioning Outcomes. (United States)

    Andersen, Barbara L.; And Others


    Studied 47 women treated for early gynecologic cancer, 18 women treated for benign gynecologic disease, and 57 gynecologically healthy women. Found that frequency of intercourse declined for women treated for disease, whether malignant or benign. Diminution of sexual excitement was pronounced for women with disease; more severe and distressing for…

  19. Diagnosis and Treatment of Benign Paroxysmal Positional Vertigo

    Directory of Open Access Journals (Sweden)

    Muhammed Dagkiran


    Full Text Available Benign paroxysmal positional vertigo is the cause of peripheral vertigo, which only takes seconds posed by certain head and body position and led to severe attacks of vertigo. Therefore, it is a disturbance that causes a continuous fear of fall and anxiety in some patients. Although benign paroxysmal positional vertigo is the most common cause of peripheral vertigo, it may cause unnecessary tests, treatment costs and the loss of labor due to the result of the delay in the diagnosis and treatment stages. Diagnosis and treatment of this disease is easy. High success rates can be achieved with appropriate repositioning maneuvers after taking a detailed medical history and accurate assessment of accompanying nystagmus. The aim of this paper was to review the updated information about benign paroxysmal positional vertigo. [Archives Medical Review Journal 2015; 24(4.000: 555-564

  20. Acute respiratory failure in a rapidly enlarging benign cervical goitre. (United States)

    Garingarao, Carlo Jan; Añonuevo-Cruz, Cecille; Gasacao, Ryan


    Benign goitres have the potential to reach massive sizes if neglected, but most have a protracted course that may or may not present with compressive symptoms. We report the case of a 57-year-old man who presented with a rapidly enlarging nodular goitre resulting in acute respiratory failure. Endotracheal intubation and emergency total thyroidectomy were performed, revealing massive thyroid nodules with minimal intrathoracic extension and tracheal erosion. Despite a course and clinical findings suggestive of malignant disease, histopathology was consistent with a benign multinodular goitre. Several cases of benign goitres necessitating endotracheal intubation have been reported. Airway compromise was attributed to a significant intrathoracic component, or inciting events such as thyroid haemorrhage, pregnancy, radioiodine uptake or major surgery. Obstructive symptoms may not correlate well with objective measures of upper airway obstruction such as radiographs or flow volume loops.

  1. Significance of isolated vasculitis in the gynecological tract: what clinicians do with the pathologic diagnosis of vasculitis? (United States)

    Roma, Andres A; Amador-Ortiz, Catalina; Liapis, Helen


    Vasculitides includes a heterogeneous group of disorders with the common histologic findings of vascular wall inflammation. Systemic or localized disease (eg, renal vasculitis) has serious consequences. The incidence of isolated gynecologic vasculitis diagnosed on pathology specimens and its significance is little known. We performed a 20 year retrospective review including 53 cases with vasculitis diagnosis affecting the female genital tract identified in pathology reports. None had prior symptoms or were diagnosed with generalized vasculitis, while one patient had prior diagnosis of fibromyalgia. Most patients presented with abnormal bleeding and were treated for conditions unrelated to vasculitis. The different types of vasculitis were: predominantly lymphocytic (nonspecific) 30 cases, necrotizing 17 cases and granulomatous 6 cases. Only 2 patients had additional serologic tests. None of the patients with isolated gynecologic vasculitis received corticosteroids or additional treatment related to the vasculitis. None of the patients developed systemic vasculitis at follow-up (2 months-19.5 years; mean, 5.5 years). Isolated gynecologic vasculitis diagnosed on pathology slides is rarely associated with systemic vasculitis. Potential isolated gynecologic vasculitis causes include: previous surgical interventions and vascular inflammation secondary to local neoplasm. In almost all cases, clinicians did not perform a thorough laboratory analysis to exclude systemic vasculitis and therapy was not required in any case, suggesting minimal clinical significance.

  2. Disease: H00844 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available H00844 Hailey-Hailey disease; Benign familial pemphigus Hailey-Hailey disease, also... known as familial benign pemphigus, is a rare, autosomal dominant skin disorder with onset in adolescence.

  3. 良性颅内压增高症误诊为眼部疾病临床分析%Clinical analysis of benign intracranial hypertension misdiagnosed as eye diseases

    Institute of Scientific and Technical Information of China (English)

    代艳; 王晓莉; 陈小虎


    目的 探讨在眼科临床诊治过程中对首诊于眼科的良性颅内压增高症(BIH)误诊的常见原因.方法 回顾分析2005年3月至2012年3月神经内、外科及眼科收治的BIH病例51例,研究其临床资料及误诊情况.结果 51例病例中有35例误诊为眼部疾病,其中误诊为视盘血管炎15例(42.9%),视神经乳头炎9例(25.7%),视神经网膜炎3例(8.6%),缺血性视神经病变1例(2.9%),青光眼2例(5.7%),外展神经麻痹5例(14.3%).结论 询问病史和神经系统检查不全面以及对良性颅内压增高症的临床特征不了解是误诊的主要原因.%Objective To discuss common reasons of benign intracranial hypertension (BIH) misdiagnosis as eye diseases in the primary survey in ophthalmology.Methods Retrospective study was taken to study the clinical data and misdiagnosis of the 51 cases with BIH from neurology,neurosurgery and ophthalmology department,from March 2005 to March 2012.Results Thirty-five of 51 cases were misdiagnosed as ocular diseases,15 cases as optic disk vasculitis (42.9%),9 cases as papillitis (25.7%),3 cases as neuroretinitis (8.6%),1 case as ischemic optic neuropathy (2.9%),2 cases as glaucoma (5.7%),5 cases as abducens paralysis (14.3%).Conclusions Main reasons of misdiagnosis for BIH include insufficient inquiry of case history,inadequate neurological exam and being not familiar with clinical features of BIH.

  4. Personalized Circulating Tumor DNA Biomarkers Dynamically Predict Treatment Response and Survival In Gynecologic Cancers.

    Directory of Open Access Journals (Sweden)

    Elena Pereira

    Full Text Available High-grade serous ovarian and endometrial cancers are the most lethal female reproductive tract malignancies worldwide. In part, failure to treat these two aggressive cancers successfully centers on the fact that while the majority of patients are diagnosed based on current surveillance strategies as having a complete clinical response to their primary therapy, nearly half will develop disease recurrence within 18 months and the majority will die from disease recurrence within 5 years. Moreover, no currently used biomarkers or imaging studies can predict outcome following initial treatment. Circulating tumor DNA (ctDNA represents a theoretically powerful biomarker for detecting otherwise occult disease. We therefore explored the use of personalized ctDNA markers as both a surveillance and prognostic biomarker in gynecologic cancers and compared this to current FDA-approved surveillance tools.Tumor and serum samples were collected at time of surgery and then throughout treatment course for 44 patients with gynecologic cancers, representing 22 ovarian cancer cases, 17 uterine cancer cases, one peritoneal, three fallopian tube, and one patient with synchronous fallopian tube and uterine cancer. Patient/tumor-specific mutations were identified using whole-exome and targeted gene sequencing and ctDNA levels quantified using droplet digital PCR. CtDNA was detected in 93.8% of patients for whom probes were designed and levels were highly correlated with CA-125 serum and computed tomography (CT scanning results. In six patients, ctDNA detected the presence of cancer even when CT scanning was negative and, on average, had a predictive lead time of seven months over CT imaging. Most notably, undetectable levels of ctDNA at six months following initial treatment was associated with markedly improved progression free and overall survival.Detection of residual disease in gynecologic, and indeed all cancers, represents a diagnostic dilemma and a potential

  5. Benign chondroblastoma - malignant radiological appearances

    Energy Technology Data Exchange (ETDEWEB)

    Schulze, K.; Treugut, H.; Mueller, G.E.


    The very rare benign chondroblastoma occasionally invades soft tissues and may grow beyond the epiphysis into the metaphysis. In the present case such a tumour did not show the typical radiological appearances, but presented malignant features both on plain films and on the angiogram. The importance of biopsy of tumours which cannot be identified with certainty must be stressed before radical surgery is carried out.

  6. Guidelines on chemotherapy in advanced stage gynecological malignancies: an evaluation of 224 professional societies and organizations.

    Directory of Open Access Journals (Sweden)

    Nikolaos P Polyzos

    Full Text Available BACKGROUND: Clinical practice guidelines are important for guiding practice, but it is unclear if they are commensurate with the available evidence. METHODS: We examined guidelines produced by cancer and gynecological societies and organizations and evaluated their coverage of and stance towards chemotherapy for advanced stage disease among 4 gynecological malignancies (breast, ovarian, cervical, endometrial cancer where the evidence for the use of chemotherapy is very different (substantial and conclusive for breast and ovarian cancer, limited and suggesting no major benefit for cervical and endometrial cancer. Eligible societies and organizations were identified through systematic internet searches (last update June 2009. Pertinent websites were scrutinized for presence of clinical practice guidelines, and relative guidelines were analyzed. RESULTS: Among 224 identified eligible societies and organizations, 69 (31% provided any sort of guidelines, while recommendations for chemotherapy on advanced stage gynecological malignancies were available in 20 of them. Only 14 had developed their own guideline, and only 5 had developed guidelines for all 4 malignancies. Use of levels of evidence and grades of recommendations, and aspects of the production, implementation, and timeliness of the guidelines did not differ significantly across malignancies. Guidelines on breast and ovarian cancer utilized significantly more randomized trials and meta-analyses. Guidelines differed across malignancies on their coverage of disease-free survival (p = 0.033, response rates (p = 0.024, symptoms relief (p = 0.005, quality of life (p = 0.001 and toxicity (p = 0.039, with breast and ovarian cancer guidelines typically covering more frequently these outcomes. All guidelines explicitly or implicitly endorsed the use of chemotherapy. CONCLUSIONS: Clinical practice guidelines are provided by the minority of professional societies and organizations

  7. 妇科常用中药介绍%Introducing common gynecological medicine

    Institute of Scientific and Technical Information of China (English)



    对用于治疗痛经、闭经、癥瘕,治疗崩漏证,治疗产后瘀阻腹痛及恶露不绝证,治疗产后虚热证等妇科疾病的中药归纳介绍。%The TCM was summarized and introduced, which for treating dysmenorrhea, amenorrhea, Zhengjia, metrorrhagia, postpartum blood stagnation abdominal pain, lochia must not, postpartum hot syndrome and other gynecological diseases.

  8. Expertise of radiation injuries in the GDR and examples of gynecological contact therapy

    Energy Technology Data Exchange (ETDEWEB)

    Arndt, D. (Staatliches Amt fuer Atomsicherheit und Strahlenschutz, Berlin (German Democratic Republic)); Lenz, U. (Betriebspoliklinik des Kombinats Elektro-Apparate-Werke Berlin-Treptow (German Democratic Republic)); Matschke, S. (Akademie der Wissenschaften der DDR, Berlin. Zentralinstitut fuer Krebsforschung); Schmidt, H. (Akademie der Wissenschaften der DDR, Leipzig. Zentralinstitut fuer Isotopen- und Strahlenforschung); Thormann, T. (Humboldt-Universitaet, Berlin (German Democratic Republic). Bereich Medizin (Charite))

    Expertise in cases of radiation injuries is given in the GDR by different institutions depending on etiological factors. Occupational diseases due to ionizing radiation are judged by the National Board of Nuclear Safety and Radiation Protection of the GDR while radiation injuries in medicine are dealt with by institutions for Medical Expertise. Details of organization and procedure of expertise are described as well as cooperation between the institutions mentioned. Two cases of iatrogenic radiation injuries in gynecological intracavitary contact therapy are dealt with and conclusions are drawn for future measures in guaranteeing full radiation protection.

  9. Manobra de Epley na vertigem posicional paroxística benigna associada à doença de Ménière Epley’s maneuver in benign paroxysmal positional vertigo associated with Meniere’s disease

    Directory of Open Access Journals (Sweden)

    Cristina Freitas Ganança


    Full Text Available Os efeitos da manobra de Epley na vertigem posicional paroxística benigna (VPPB associada à doença de Ménière são controvertidos. OBJETIVO: Avaliar a vertigem e o nistagmo de posicionamento após uma ou mais manobras de Epley na vertigem posicional paroxística benigna (VPPB associada à doença de Ménière e na recorrência da VPPB. MATERISL E MÉTODO: Estudo retrospectivo de 62 pacientes com VPPB associada à doença de Ménière submetidos à manobra de Epley e acompanhados durante 12 meses após a extinção do nistagmo de posicionamento. RESULTADOS: Para abolir o nistagmo de posicionamento, foi necessária uma manobra de Epley em 80,7% dos pacientes, duas em 16,1% e três em 3,2%. A vertigem foi eliminada em 71,0% dos pacientes, melhorou em 27,4% e permaneceu inalterada em 1,6%. Quatro semanas após a extinção do nistagmo de posicionamento, todos os pacientes ficaram assintomáticos. Recorrência da VPPB foi observada em 19,4% dos casos, com eliminação da vertigem e nistagmo de posicionamento à manobra específica para o canal afetado. CONCLUSÕES: Na VPPB associada à doença de Ménière, vertigem e nistagmo de posicionamento foram eliminados com uma, duas ou três manobras de Epley. A recorrência da VPPB foi resolvida com uma manobra para o canal envolvido.The effects of Epley’s maneuver in benign paroxysmal positional vertigo (BPPV associated with Menière’s disease are controversial. AIMS: To evaluate the progression of positional vertigo and nystagmus after one or more of Epley’s maneuvers in BPPV associated with Menière’s disease, and the recurrence of BPPV. METHOD: a retrospective study of 62 patients with BPPV associated with Menière’s disease, that underwent Epley’s maneuver, and that were monitored during 12 months after elimination of positional nystagmus. RESULTS: One Epley’s maneuver was required to eliminate positional nystagmus in 80.7% of the patients, two in 16.1%, and three in 3.2%; after

  10. Beta-adrenoceptors in obstetrics and gynecology. (United States)

    Modzelewska, Beata


    One hundred and twenty years after the description of extracts from the adrenal medulla, the use of beta-blockers and beta-agonists evolved from antianginal drugs and tocolytics to ligand-directed signaling. Beta-blockers in the fields of obstetrics and gynecology have so far been limited to the consideration of continuing treatment of disorders of the cardiovascular system and other dysfunctions that started before pregnancy. Studies in recent years have shown that beta-adrenoceptor signaling might be crucial in carcinogenesis and metastasis, apoptosis and anoikis. On the other hand, the use of beta-adrenoceptor agonists in tocolysis is, as yet, the primary method for inhibiting premature uterine contractions. Unfortunately, the efficacy of current pharmacological treatment for the management of preterm labor is regularly questioned. Moreover, studies related to non-pregnant myometrium performed to date indicate that the rhythmic contractions of the uterus are required for menstruation and have an important role in human reproduction. In turn, abnormal uterine contractility has been linked to dysmenorrhea, a condition associated with painful uterine cramping. The benefits of the use of beta2-adrenoceptor agonists in dysmenorrhea are still unclear and should be balanced against a wide range of adverse effects recognized with this class of medication. The ideal tocolytic agent is one which is effective for the pregnant or non-pregnant woman but has no side effects on either the woman or the baby. Looking to the future with both caution and hope, the potential metamorphosis of beta3-adrenoceptor agonists from experimental tools into therapeutic drugs for tocolysis warrants attention.

  11. Characterization of Pregnant Women with Heart Disease at the “Ramón Gonzalez Coro” Gynecologic and Obstetric Teaching Hospital Caracterización de las gestantes con cardiopatías en el Hospital Docente Ginecobstétrico “Ramón González Coro”

    Directory of Open Access Journals (Sweden)

    Yanara Gutierrez Aliaga


    Full Text Available Introduction: pregnancy-related heart disease is nowadays the first cause of maternal morbidity and mortality among pregnancy-related pathologies. Objective: to characterize pregnant women with heart disease according to demographic and clinical features. Method: a descriptive study with some analytic aspects was conducted in the Heart Disease and Pregnancy service of “Ramón Gonzalez Coro’’ Gynecologic and Obstetric Teaching Hospital from 2000-2009. The universe consisted on the 472 pregnant women with heart disease that received follow up during that period. They were treated according to the protocol applied since 2000. Data were obtained through a questionnaire and were processed using the SPSS 11,5 system for Windows, through determination of absolute and relative frequencies. They included: mothers’ age, first and third trimester functional classification, drugs used and cardiovascular complications. Results: valvular heart diseases (25, 6 % were the most common type of heart disease. Important modifications were found at the end of pregnancy for the functional degree. Complications were registered in 29,9 % of patients, being pulmonary acute edema (6,4 %, cardiac arrest (4,3 % and arrhythmias (3,5 %, the most common ones. Pulmonary thomboembolism was the cause of the two maternal deaths that occurred. Conclusion: valvular heart diseases were the most common cardiac disease detected in the patients included in our study. Most of them were classified as functional degree I, being pregnancy a potential risk for them.Introducción: el embarazo en las mujeres cardiópatas constituye hoy, la primera causa de morbi-mortalidad materna entre las patologías asociadas al embarazo. Objetivo: caracterizar a las gestantes con cardiopatía desde el punto de vista clínico y demográfico. Método: estudio

  12. Imaging of gynecological disorders in infants and children

    Energy Technology Data Exchange (ETDEWEB)

    Mann, Gurdeep S. [Alder Hey Children' s Hospital, Liverpool (United Kingdom). Dept. of Paediatric Radiology; Blair, Joanne C. [Alder Hey Children' s Hospital, Liverpool (United Kingdom). Dept. of Paediatric Endocrinology; Garden, Anne S. (eds.) [Alder Hey Children' s Hospital, Liverpool (United Kingdom). Dept. of Paediatric Gynaecology; Lancaster Univ. (United Kingdom). Lancaster Medical School


    This textbook provides a comprehensive review of gynecological imaging in infancy, childhood, and adolescence. Experts from the disciplines of pediatric radiology, gynecology, surgery, and endocrinology have come together to produce a textbook that, while written primarily from the perspective of the radiologist, will be of interest to all professionals involved in the management of these patients. The normal development of the female reproductive tract is described in detail through embryological development, normal childhood appearances, and puberty. Congenital abnormalities are addressed in chapters reviewing structural abnormalities of the reproductive tract and disorders of sex development. A symptoms-based approach is followed in chapters devoted to the assessment of the patient with gynecological pain and disorders of menstruation. Disorders of the breast and the imaging of patients with gynecological neoplasia are considered in dedicated chapters. The specialty of pediatric gynecology is evolving rapidly, drawing on the skills and expertise of professionals from a wide range of specialties. This textbook should prove valuable to all who are involved in this new field of medicine. (orig.)

  13. Risk stratification for benign prostatic hyperplasia. (United States)

    Zattoni, Fabio; Ficarra, Vincenzo; Novara, Giacomo


    Benign prostatic hyperplasia (BPH) represents an important public health problem in ageing men due to frequently associated lower urinary tract symptoms (LUTS), which may impair quality of life. BPH is also a progressive disease, mainly characterized by a worsening of LUTS over time, and in some patients by the occurrence of serious outcomes such as acute urinary retention and need for BPH-related surgery. The management of BPH and LUTS in men should move forward its focus on symptom control only. Indeed, the goals of therapy for BPH are not only to improve bothersome LUTS but also to identify those patients at risk of unfavourable outcomes in order to optimize their management and reduce complications. Risk stratification and tailored treatment should improve the reductions in both symptoms and the long-term consequences of BPH and BPH treatments. To do this, clinicians need to know possible factors that may support the develop of PBH and possible risks due to the BPH itself.

  14. Diffusion-Weighted Magnetic Resonance Imaging of Endometrial Cancer: Differentiation from Benign Endometrial Lesions and Preoperative Assessment of Myometrial Invasion

    Energy Technology Data Exchange (ETDEWEB)

    Takeuchi, M.; Matsuzaki, K.; Nishitani, H. (Dept. of Radiology, Univ. of Tokushima, Tokushima (Japan))


    Background: Uterine endometrial cancer is the most common gynecologic malignancy, and benign endometrial hyperplasia or polyps should be differentiated from endometrial cancer. In evaluating endometrial cancer on magnetic resonance imaging (MRI), the assessment of the depth of myometrial invasion is important because it closely correlates with the patient's prognosis. Purpose: To verify the feasibility of diffusion-weighted magnetic resonance imaging (DWI) to distinguish benign and malignant endometrial lesions, and to evaluate myometrial invasion of endometrial cancer. Material and Methods: Sixty-seven endometrial lesions including 45 cancers and 22 benign lesions (hyperplasia and polyps) were evaluated by DWI with apparent diffusion coefficient (ADC) measurement. The staging accuracies of DWI and gadolinium-enhanced T1-weighted images in the assessment of myometrial invasion were evaluated in 33 patients with endometrial cancer. Results: The ADC values (x10-3 mm2/s) in cancer and benign lesions were 0.84+-0.19 and 1.58+-0.36, respectively (P<0.01). The staging accuracy (superficial or deep myometrial invasion) was 94% for DWI and 88% for gadolinium-enhanced T1-weighted images. Coexisting adenomyosis and infiltrative myometrial invasion caused staging errors on gadolinium-enhanced T1-weighted images, whereas DWI could demonstrate the tumor extent correctly. Conclusion: DWI provides helpful information in evaluating benign and malignant endometrial lesions.

  15. Benign infantile seizures and paroxysmal dyskinesia caused by an SCN8A mutation

    DEFF Research Database (Denmark)

    Gardella, Elena; Becker, Felicitas; Møller, Rikke S


    Objective: Benign familial infantile seizures (BFIS), paroxysmal kinesigenic dyskinesia (PKD), and their combination-known as infantile convulsions and paroxysmal choreoathetosis (ICCA)-are related autosomal dominant diseases. PRRT2 (proline-rich transmembrane protein 2 gene) has been identified...

  16. Use of a Flexible Inflatable Multi-Channel Applicator for Vaginal Brachytherapy in the Management of Gynecologic Cancer


    Shin, Samuel M.; Duckworth, Tamara L.; Benjamin Thomas Cooper; Curtin, John P.; Schiff, Peter B.; J Keith DeWyngaert; Stella C Lymberis


    Introduction: Evaluate use of novel multi-channel applicator (MC) CapriTM to improve vaginal disease coverage achievable by single-channel applicator (SC) and comparable to Syed plan simulation. Material and Methods: 28 plans were evaluated from 4 patients with primary or recurrent gynecologic cancer in the vagina. Each received whole pelvis radiation, followed by 3 weekly treatments using HDR brachytherapy with a 13-channel MC. Upper vagina was treated to 5 mm depth to 1500 cGy/3 fractions...

  17. Use of a Flexible Inflatable Multi-Channel Applicator for Vaginal Brachytherapy in the Management of Gynecologic Cancer


    Shin, Samuel M.; Duckworth, Tamara L.; Cooper, Benjamin T; Curtin, John P.; Schiff, Peter B.; DeWyngaert, J. Keith; Stella C Lymberis


    Introduction Evaluate use of novel multi-channel applicator (MC) Capri™ to improve vaginal disease coverage achievable by single-channel applicator (SC) and comparable to Syed plan simulation. Materials and methods Twenty-eight plans were evaluated from four patients with primary or recurrent gynecologic cancer in the vagina. Each received whole pelvis radiation, followed by three weekly treatments using HDR brachytherapy with a 13-channel MC. Upper vagina was treated to 5 mm depth...

  18. Safety considerations for office-based obstetric and gynecologic procedures. (United States)

    Urman, Richard D; Punwani, Nathan; Bombaugh, Maryanne; Shapiro, Fred E


    The migration of gynecologic procedures to office-based settings provides numerous advantages for patients and providers alike, including reduced patient expenses, improved scheduling convenience, favorable provider reimbursement, and enhanced continuity of care and patient satisfaction. With rising health care costs-a major concern in health care-procedures will continue to shift to practice environments that optimize care, quality, value, and efficiency. It is imperative that gynecologic offices ensure that performance and quality variations are minimized across different sites of care; physicians should strive to provide care to patients that optimizes safety and is at least equivalent to that delivered at traditional sites. The gynecologic community should nonetheless heed the Institute of Medicine's recommendations and embrace continuous quality improvement. By exercising leadership, office-based gynecologists can forge a culture of competency, teamwork, communication, and performance measurement.

  19. Update on immune checkpoint inhibitors in gynecological cancers (United States)


    In recent years, progress in our understanding of immune-modulatory signaling pathways in immune cells and the tumor microenvironment (TME) has led to rejuvenated interest in cancer immunotherapy. In particular, immunotherapy targeting the immune checkpoint receptors such as cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), programmed cell-death 1 (PD-1), and programmed cell-death ligand 1 (PD-L1) have demonstrated clinical activity in a wide variety of tumors, including gynecological cancers. This review will focus on the emerging clinical data on the therapeutic role of immune checkpoint inhibitors, and potential strategies to enhance the efficacy of this class of compounds, in the context of gynecological cancers. It is anticipated that future biomarker-directed clinical trials will provide further insights into the mechanisms underlying response and resistance to immunotherapy, and help guide our approach to designing therapeutic combinations that have the potential to enhance the benefit of immunotherapy in patients with gynecologic cancers. PMID:28028993

  20. Annual report of the Committee on Gynecologic Oncology, the Japan Society of Obstetrics and Gynecology. (United States)

    Yamagami, Wataru; Aoki, Daisuke


    The Japan Society of Obstetrics and Gynecology collects and analyzes annual data on gynecologic cancers from member institutions. Here we present the Patient Annual Report for 2012 and the Treatment Annual Report for 2006. Data on 7028 patients with cervical cancer, 8217 with endometrial cancer, 5140 with ovarian cancer and 1725 with ovarian borderline tumor for whom treatment was initiated in 2012 were summarized in the Patient Annual Report. Data on the prognosis of 2699 patients with cervical cancer, 3243 with endometrial cancer and 1898 with ovarian cancer for whom treatment was initiated in 2006 were analyzed in the Treatment Annual Report. In the Patient Annual Report for 2012, stage I accounted for 55.4%, stage II for 23.0%, stage III for 11.0% and stage IV for 10.6% of all patients with cervical cancer. Stage I accounted for 72.2%, stage II for 7.0%, stage III for 13.4% and stage IV for 7.3% of all patients with endometrial cancer. Stage I accounted for 43.1%, stage II for 9.2%, stage III for 29.7% and stage IV for 7.2% of all patients with ovarian cancer. In the Treatment Annual Report for 2006, the 5-year overall survival rates for patients with cervical cancer were 92.9% for stage I, 74.6% for stage II, 55.3% for stage III and 24.3% for stage IV. The equivalent rates for patients with endometrial cancer were 96.3%, 92.7%, 80.6% and 35.8%, respectively; and those for patients with ovarian surface epithelial-stromal tumors were 90.6%, 82.9%, 48.7% and 40.9%, respectively.

  1. Diagnosis of gynecological pseudoaneurysms and embolization with cyanoacrylate. (United States)

    Fernández Bermúdez, M J; Fernández Martínez, A M; Domitrovic, L A; Balboa Arregui, Ó


    Pseudoaneurysms of the uterine artery are an uncommon cause of severe gynecological bleeding secondary to surgical manipulation of the pelvis or to instrumental delivery. The different imaging techniques are of vital importance in the diagnosis. Angiography is the technique used for confirmation and also for treatment in many cases. Endovascular treatment by embolizing the pseudoaneurysm has become established as the treatment of choice, making it possible to avoid hysterectomy in women of childbearing age. This article presents two cases of gynecological bleeding due to pseudoaneurysms (one secondary to surgery and one secondary to childbirth) that were embolized in a novel way using cyanoacrylate.

  2. [Gynecologic laparoscopy at the ABC Hospital. Analysis of 882 cases]. (United States)

    Díaz Argüello, D; Barrón Vallejo, J; Rojas Poceros, G; Kably Ambe, A


    The objective was to evaluate the indications and clinical evolution of patients treated with laparoscopy. Eight hundred eighty two women undergoing conventional laparoscopy for gynecological pathology, patients were not preselected, preoperative and postoperative data were registered retrospectively. Main indications to perform laparoscopy were dismenorrhea and infertility. Endometriosis and pelvic adhesions were the most frequent findings detected in the study subjects. Endoscopic treatment resulted in minimal complications and short postoperative stay. As conclusion classic laparoscopy is a safe and efficacious technique for treatment gynecological pathology.

  3. Predicting perioperative venous thromboembolism in Japanese gynecological patients.

    Directory of Open Access Journals (Sweden)

    Masae Ikeda

    Full Text Available OBJECTIVE: To develop a convenient screening method that can predict perioperative venous thromboembolism (VTE and identify patients at risk of fatal perioperative pulmonary embolism (PE. METHODS: Patients hospitalized for gynecological abdominal surgery (n = 183 underwent hematology tests and multidetector computed tomography (MDCT to detect VTE. All statistical analyses were carried out using the SPSS software program (PASWV19.0J. RESULTS: The following risk factors for VTE were identified by univariate analysis: plasmin-alpha2-plasmin inhibitor complex (PIC, thrombin-antithrombin III complex (TAT, and prolonged immobility (all p<0.001; age, neoadjuvant chemotherapy (NAC, malignancy, hypertension, past history of VTE, and hormone therapy (all p<0.01; and hemoglobin, transverse tumor diameter, ovarian disease, and menopause (all p<0.05. Multivariate analysis using these factors revealed that PIC, age, and transverse tumor diameter were significant independent determinants of the risk of VTE. We then calculated the incidence rate of perioperative VTE using PIC and transverse tumor diameter in patient groups stratified by age. In patients aged ≤40 years, PIC ≥1.3 µg/mL and a transverse tumor diameter ≥10 cm identified the high-risk group for VTE with an accuracy of 93.6%. For patients in their 50 s, PIC ≥1.3 µg/mL identified a high risk of VTE with an accuracy of 78.2%. In patients aged ≥60 years, a transverse tumor diameter ≥15 cm (irrespective of PIC or PIC ≥1.3 µg/mL identified the high-risk group with an accuracy of 82.4%. CONCLUSIONS: We propose new screening criteria for VTE risk that are based on PIC, transverse tumor diameter, and age. Our findings suggest the usefulness of these criteria for predicting the risk of perioperative VTE and for identifying patients with a high risk of fatal perioperative PE.

  4. Variáveis reprodutivas e risco para doenças benignas de mama: estudo caso-controle Reproductive variables and risk of benign breast diseases: a case-control study

    Directory of Open Access Journals (Sweden)

    Ellen E. Hardy


    Full Text Available Foram estudadas 257 mulheres com diagnóstico de doença benigna de mama (DBM, atestado por anatomopatológico ou citologia, e um controle para cada uma delas. Foram apresentados resultados das possíveis relações entre variáveis reprodutivas e o risco para DBM. Os casos e controles foram comparados levando em conta a idade na menarca e na menopausa, o número de gravidezes, de meses em que amamentaram e de ciclos menstruais ovulatórios, e os antecedentes familiares de câncer de mama. Mostraram influência significativa, em relação às DBM, a nuliparidade, aumentando o risco enquanto a idade de 30 ou mais anos no primeiro parto o reduziu; o número de ciclos ovulatórios, que foi significativamente maior para os casos, e a média de meses de uso de pílula, menor entre as mulheres com DBM. O uso de contraceptivos orais apresentou um efeito protetor apenas quando a duração total do uso foi maior que dois anos. Os resultados não se revelaram novos ou diferentes se comparados com outros estudos, mas confirmam a relativa concordância entre os fatores de risco para DBM e para câncer de mama, ainda que as relações entre esses fatores e as DBM não sejam tão claras como o são para o câncer, e existam também algumas discrepâncias.The purpose of the study was the identification of risk factors for benign breast diseases (BBD; 257 women with BBD diagnosed through pathological anatomy or citology and a matched control for each were studied. Subjects were selected at The State University of Campinas Hospital and at a private clinic. To enter the study cases had to have a first diagnosis of BBD between October 1979 and August 1984. The following BBD were considered: dysplasia, fibroadenoma, cystic disease, papilloma and ductal ectasia. Reproductive variables were studied as risk factors, including menstrual ovulatory cycles. The date on which the BBD was diagnosed was defined as the index date. For controls, data were considered up to when

  5. 21 CFR 884.4520 - Obstetric-gynecologic general manual instrument. (United States)


    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Obstetric-gynecologic general manual instrument... Surgical Devices § 884.4520 Obstetric-gynecologic general manual instrument. (a) Identification. An obstetric-gynecologic general manual instrument is one of a group of devices used to perform...

  6. Effectiveness of the Gynecology Teaching Associate in Teaching Pelvic Examination Skills. (United States)

    Guenther, Susan M.; And Others


    The effectiveness of using gynecology teaching associates is compared with training by gynecology residents on clinic patients for teaching the gynecologic examination. Sophomore medical students at the University of Iowa participated in the instruction and an evaluation session with a simulated patient trained to rate the students' examination…

  7. 76 FR 50485 - Obstetrics and Gynecology Devices Panel of the Medical Devices Advisory Committee; Amendment of... (United States)


    ... HUMAN SERVICES Food and Drug Administration Obstetrics and Gynecology Devices Panel of the Medical... Obstetrics and Gynecology Devices Panel of the Medical Devices Advisory Committee. This meeting was announced... July 14, 2011, FDA announced that a meeting of the Obstetrics and Gynecology Devices Panel of...

  8. The spectrum of benign esophageal lesions: imaging findings

    Energy Technology Data Exchange (ETDEWEB)

    Jang, Kyung Mi; Lee, Kyung Soo; Lee, Soon Jin; Kim, Eun A; Kim, Tae Sung; Han, Dae Hee; Shim, Young Mog [Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)


    Benign esophageal lesions occur in various diseases. Barium studies are useful for the evaluation of mucosal surface lesions but provide little information about the extramucosal extent of disease. Computed tomography and magnetic resonance imaging, on the other hand, permit the assessment of wall thickness, mediastinal involvement, adjacent lymphadenopathy, and distant spread. In diseases such as fibrovascular polyps, duplication cysts, scleroderma, trauma, caustic esophagitis, hiatal hernia, esophageal diverticulum, achalasia, and paraesophageal varices, the findings of imaging studies are specific, obviating the need for further invasive diagnostic work-up. The advent of helical computed tomography and its volume data set allows the acquisition of multiplanar images, and magnetic resonance imaging is useful both for this and for tissue characterization. Thus, multiplanar cross-sectional imaging further extends the role of imaging modalities to the evaluation of benign esophageal lesions. Through an awareness of the multiplanar cross-sectional appearances of various benign esophageal lesions, the radiologist can play an important role in the detection, diagnosis, further diagnostic planning, and treatment of the diseases in which they occur.

  9. Benign Papules and Nodules of Oral Mucosa

    Directory of Open Access Journals (Sweden)

    Mehmet Salih Gürel


    Full Text Available This article reviews some of the more common benign oral papules and nodules of oral mucosa with emphasis on their etiology, epidemiology, clinical presentation, histopathology, and treatment. These lesions include mucocele, traumatic fibroma, epulis, pyogenic granuloma, oral papilloma, oral warts, lymphangioma, hemangioma, lipoma, oral nevi and some soft tissue benign tumors. These benign lesions must be separated clinically and histologically from precancerous and malign neoplastic lesions. Accurate clinico-pathological diagnosis is mandatory to insure appropriate therapy.

  10. Assessing the prevalence of autoimmune, endocrine, gynecologic, and psychiatric comorbidities in an ethnically diverse cohort of female fibromyalgia patients: does the time from hysterectomy provide a clue?

    Directory of Open Access Journals (Sweden)

    Brooks L


    Full Text Available Larry Brooks,1 Joseph Hadi,2 Kyle T Amber,1 Michelle Weiner,3 Christopher L La Riche,4 Tamar Ference1 1Department of Rehabilitation Medicine, University of Miami Miller School of Medicine, Miami, 2Anesco Interventional Pain Institute, Margate, 3Miami Pain and Diagnostics, Miami, 4Department of Psychiatry and Behavioral Health, Florida International University Wertheim College of Medicine, University Park, FL, USABackground: This retrospective chart review investigated differences in the prevalence of medical comorbidity between women with fibromyalgia (FM (n=219 and a control group women with chronic pain (CP without FM (n=116. The specific aims were to compare the prevalence of autoimmune, psychiatric, endocrine, gynecologic pathology, the relationship between timing of gynecologic surgery, and pain onset. We additionally sought to compare the number of comorbidities in an ethnically diverse cohort.Methods: This was a retrospective chart review of patients seen in FM or CP clinics at an academic medical center in 2009–2010.Results: Logistic regression modeling found that gynecologic, endocrine, and autoimmune diagnoses were independently associated with a diagnosis of FM. Detailed analyses showed that thyroid disease (P<0.01 and gynecologic surgery (P<0.05 were significantly more common in FM. Women with FM were more likely to have multiple autoimmune, endocrine, gynecologic, or psychiatric pathologies. A relationship was observed between the timing of gynecologic surgery and pain onset in FM, with more surgeries observed in the years just prior to pain onset or in the year after pain onset. A similar pattern was not found in the control group.Conclusion: This study demonstrates that autoimmune, endocrine, and gynecologic pathologies occur more commonly in women with FM than in those with CP, which is consistent with findings in less ethnically diverse samples. Moreover, a relationship was found between timing of pain onset and gynecologic

  11. Anti-hemorrhagic effect of prophylactic tranexamic acid in benign hysterectomy-a double-blinded randomized placebo-controlled trial

    DEFF Research Database (Denmark)

    Topsoee, Märta Fink; Bergholt, Thomas; Ravn, Pernille;


    BACKGROUND: Hysterectomy is one of the most frequently performed major gynecological surgical procedures. Even when the indication for the procedure is benign, relatively high complication rates have been reported. Perioperative bleeding seems to represent the most common cause of complications...... and in 2004, 8% of all women in Denmark undergoing benign hysterectomy experienced a bleeding complication. Tranexamic acid is an antifibrinolytic agent that has shown to effectively reduce bleeding complications within other surgical and medical areas. However, knowledge about the drug's effect in relation...... 2014. A total of 332 women undergoing benign abdominal, laparoscopic, or vaginal hysterectomy were included in the trial, randomized to either 1 g of intravenous tranexamic acid or placebo at start of surgery. Chi-square test and Student t test statistical analyses were applied. RESULTS: The primary...

  12. Consideration of Drug Therapy in Benign Prostatic Hypertrophy

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    G. Diamantis


    Full Text Available Benign prostatic hypertrophy (BPH has become a major global health problem both in its frequency by which it determines the complications and the problems of diagnosis and treatment it requires. BPH is a heterogeneous disease. The symptoms attributed to BPH may have other coexisting causes and growth factors both androgen-dependent and independent, which promotes prostate enlargement. It is well known that prostate size correlates poorly with the symptoms so that reducing prostate using 5-alphareductase or alphablocants inhibitors may not always be sufficient. A better understanding of the pathophysiology of BPH and its interactions with other drugs will help the development of new substances with a better efficiency. This present work aims to be a modest contribution related to medical treatment in benign prostatic hyperplasia and the role that the generalist practitioner should play in managing of this urinary disease quite common in elderly men.

  13. Revised criteria for suspicion of non-benign positional vertigo. (United States)

    Soto-Varela, A; Rossi-Izquierdo, M; Sánchez-Sellero, I; Santos-Pérez, S


    Benign paroxysmal positional vertigo (BPPV) is the most commonly diagnosed vestibular vertigo. BPPV can be diagnosed by clinical examination and its treatment is based on particle repositioning manoeuvres, and specialized equipment is not required. Therefore, most patients could be diagnosed and treated by their general practitioner. Unfortunately, not all positional vertigos are benign. Symptoms similar to those of BPPV can be caused by diseases that affect the central nervous system. It must be possible to define criteria that allow us to suspect, in a patient with symptoms of positional vertigo, the possibility of a cerebral origin ('non-benign PV'). Requests for magnetic resonance imaging must be justified by the fulfillment of these criteria. That is especially relevant in primary care, because these criteria should make possible to distinguish between patients with positional vertigo that could be treated by general practitioner and patients that need to be directed to especialized units. We propose the following revised criteria for suspected non-benign PV: (i) association with signs or symptoms of neurological disorder, (ii) nystagmus without dizziness in positional diagnostic tests, (iii) atypical nystagmus direction, (iv) poor response to therapeutic manoeuvres and (v) recurrence (confirmed by positional tests) on at least three occasions.

  14. Hematological Toxicity After Robotic Stereotactic Body Radiosurgery for Treatment of Metastatic Gynecologic Malignancies

    Energy Technology Data Exchange (ETDEWEB)

    Kunos, Charles A., E-mail: [Department of Radiation Oncology, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine, Cleveland, Ohio (United States); Debernardo, Robert [Department of Obstetrics and Gynecology, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine, Cleveland, Ohio (United States); Radivoyevitch, Tomas [Department of Epidemiology and Biostatistics, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine, Cleveland, Ohio (United States); Fabien, Jeffrey; Dobbins, Donald C.; Zhang Yuxia; Brindle, James [Department of Radiation Oncology, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine, Cleveland, Ohio (United States)


    Purpose: To evaluate hematological toxicity after robotic stereotactic body radiosurgery (SBRT) for treatment of women with metastatic abdominopelvic gynecologic malignancies. Methods and Materials: A total of 61 women with stage IV gynecologic malignancies treated with abdominopelvic SBRT were analyzed after ablative radiation (2400 cGy/3 divided consecutive daily doses) delivered by a robotic-armed Cyberknife SBRT system. Abdominopelvic bone marrow was identified using computed tomography-guided contouring. Fatigue and hematologic toxicities were graded by retrospective assignment of common toxicity criteria for adverse events (version 4.0). Bone marrow volume receiving 1000 cGy (V10) was tested for association with post-therapy (median 32 days [25%-75% quartile, 28-45 days]) white- or red-cell counts, hemoglobin levels, and platelet counts as marrow toxicity surrogates. Results: In all, 61 women undergoing abdominopelvic SBRT had a median bone marrow V10 of 2% (25%-75% quartile: 0%-8%). Fifty-seven (93%) of 61 women had received at least 1 pre-SBRT marrow-taxing chemotherapy regimen for metastatic disease. Bone marrow V10 did not associate with hematological adverse events. In all, 15 grade 2 (25%) and 2 grade 3 (3%) fatigue symptoms were self-reported among the 61 women within the first 10 days post-therapy, with fatigue resolved spontaneously in all 17 women by 30 days post-therapy. Neutropenia was not observed. Three (5%) women had a grade 1 drop in hemoglobin level to <10.0 g/dL. Single grade 1, 2, and 3 thrombocytopenias were documented in 3 women. Conclusions: Abdominopelvic SBRT provided ablative radiation dose to cancer targets without increased bone marrow toxicity. Abdominopelvic SBRT for metastatic gynecologic malignancies warrants further study.

  15. Role of the chosen general practitioner in educating women on the importance of regular gynecological examinations

    Directory of Open Access Journals (Sweden)

    Markov Zlatka


    Full Text Available Introduction. Since regular screening is the best way of preventing the development of cervical cancer, the objective has been set to assess the motivation of women to have regular gynecological examinations and to estimate the role of the chosen general practitioner. Material and Methods. The survey was performed on the basis of the prospective study done at the Health Centre ”Novi Sad” in 2009 during the systematic regular examinations carried out by general practitioners. Results. It was found that 60.8% of the examined women had regular checkups; 21.5% visited their doctor once in the period of two to five years and 4.9% had undergone the examination in a period > 10 years, whereas 1.9 women had never had an examination. Other examinees had occasional check-ups with various time laps between them. Discussion. The reasons for not visiting a gynecologist were fear of the examination, absence of discomforts and lack of time. However, 87.2% of the examinees visited a gynecologist after they had been advised to do so by their general practitioner. Gynecological finding was good in 87.6% of the women, 3.4% were found to have carcinoma and 8.9% had some other abnormal finding. Conclusion. According to the obtained results, it has been concluded that the chosen general practitioner has a very important role in motivating women to have regular gynecological examinations and in educating them on the risk factors for developing malignant diseases and on the possible prevention.

  16. Development of an open source software module for enhanced visualization during MR-guided interstitial gynecologic brachytherapy. (United States)

    Chen, Xiaojun; Egger, Jan


    In 2010, gynecologic malignancies were the 4th leading cause of death in U.S. women and for patients with extensive primary or recurrent disease, treatment with interstitial brachytherapy may be an option. However, brachytherapy requires precise insertion of hollow catheters with introducers into the tumor in order to eradicate the cancer. In this study, a software solution to assist interstitial gynecologic brachytherapy has been investigated and the software has been realized as an own module under (3D) Slicer, which is a free open source software platform for (translational) biomedical research. The developed research module allows on-time processing of intra-operative magnetic resonance imaging (iMRI) data over a direct DICOM connection to a MR scanner. Afterwards follows a multi-stage registration of CAD models of the medical brachytherapy devices (template, obturator) to the patient's MR images, enabling the virtual placement of interstitial needles to assist the physician during the intervention.

  17. Laminaria species and usefulness in obstetrics and gynecology

    Institute of Scientific and Technical Information of China (English)

    Beuy Joob; Viroj Wiwanitkti


    Laminaria species is a group of marine algae that is generally known as sea brown algae. It can be seen around the world and the coastal people have known it for years. The use ofLaminaria spp. in medicine is very interesting. In this short article, the authors summarized and discussed onLaminaria spp. and usefulness in obstetrics and gynecology.

  18. Students' and Physicians' Evaluations of Gynecologic Teaching Associate Program. (United States)

    Plauche, Warren C.; Baugniet-Nebrija, Wendy


    Gynecologic teaching associates taught third-year medical students to perform physical examination of the female pelvis and breasts. Evaluations by the students of this teaching method and assessment by the teaching associates of student problems were obtained from questionnaires. (Author/MLW)

  19. Robotics in Gynecology: Why is this Technology Worth Pursuing? (United States)

    Ayala-Yáñez, Rodrigo; Olaya-Guzmán, Emilio José; Haghenbeck-Altamirano, Javier


    Robotic laparoscopy in gynecology, which started in 2005 when the Da Vinci Surgical System (Intuitive Surgical Inc) was approved by the US Food and Drug Administration for use in gynecologic procedures, represents today a modern, safe, and precise approach to pathology in this field. Since then, a great deal of experience has accumulated, and it has been shown that there is almost no gynecological surgery that cannot be approached with this technology, namely hysterectomy, myomectomy, sacrocolpopexia, and surgery for the treatment of endometriosis. Albeit no advantages have been observed over conventional laparoscopy and some open surgical procedures, robotics do seem to be advantageous in highly complicated procedures when extensive dissection and proper anatomy reestablishment is required, as in the case of oncologic surgery. There is no doubt that implementation of better logistics in finance, training, design, and application will exert a positive effect upon robotics expansion in gynecological medicine. Contrary to expectations, we estimate that a special impact is to be seen in emerging countries where novel technologies have resulted in benefits in the organization of health care systems. PMID:24453521

  20. A National Survey of Undergraduate Teaching in Obstetrics and Gynecology. (United States)

    And Others; Stenchever, Morton A.


    A survey of academic departments of obstetrics and gynecology was designed to assess undergraduate educational programs and the impact of efforts made to improve teaching in the specialty. It focuses on instructional patterns, the clinical clerkship, student evaluation, and program administration and evaluation. Prior surveys are noted.…

  1. First Nordic Conference on Obesity in Gynecology and Obstetrics (NOCOGO)

    DEFF Research Database (Denmark)

    Jørgensen, Jan Stener; Vinter, Christina A; Lamont, Ronald F;


    The First Nordic Conference in Obesity in Gynecology and Obstetrics (NOCOGO) took place in Billund, Denmark between 22(nd) and 24(th) October 2012. The goal of the meeting was to encourage attendance and interaction between obstetricians, gynecologists, nurses and midwives with regard to obesity...

  2. Continuum of Medical Education in Obstetrics and Gynecology. (United States)

    Dohner, Charles W.; Hunter, Charles A., Jr.


    Over the past eight years the obstetric and gynecology specialty has applied a system model of instructional planning to the continuum of medical education. The systems model of needs identification, preassessment, instructional objectives, instructional materials, learning experiences; and evaluation techniques directly related to objectives was…

  3. Lymphoid proliferations in the orbit: malignant or benign?


    van der Gaag, R.; Koornneef, L.; Heerde, P. van; Vroom, T M; Pegels, J H; Feltkamp, C.A.; Peeters, H J; Gillissen, J P; Bleeker, G M; Feltkamp, T E


    Clinical, pathological, and immunological analysis of 20 patients with ocular adnexal lymphoid disease has demonstrated several parameters which are useful for distinguishing malignant from benign lesions. Patients in the fourth or fifth decade of life presenting with an acute history of pain, oedema, epiphora, double vision, and ptosis, with a mass localised in the lacrimal gland area, are more likely to have a pseudolymphoma or a chronic inflammatory lesion than a true non-Hodgkin lymphoma ...

  4. Benign communicating hydrocephalus in children

    Energy Technology Data Exchange (ETDEWEB)

    Kendall, B.; Holland, I.


    A review was performed of the computed tomograms (CTs) of 500 children which had been reported as showing widening of the supratentorial subarachnoid spaces with normal cerebral substance. On the basis of this a radiological diagnosis of cerebral atrophy had been made in all but five, who were said to have mengalencephaly. From these, the children with large or abnormally enlarging heads, but normal or only slightly enlarged ventricles, were selected; there were 40 such cases (8%). The clinical condition either improved or remained stable over a period of 2 years; in the majority the scan abnormality regressed (22.5%) or remained static (67.5%). In three cases there was slight progression of the CT changes before stabilisation, but only one case developed classical communicating hydrocephalus necessitating a shunt procedure. This condition is a generally benign and mild form of communicating hydrocephalus, for which an aetiological factor was apparent in about two-thirds of the cases studied.

  5. Benign paroxysmal torticollis in infancy

    Directory of Open Access Journals (Sweden)

    Dimitrijević Lidija


    Full Text Available Background. Benign paroxysmal torticollis (BPT is an episodic functional disorder of unknown etiology, characterized by the periods of torticollic posturing of the head, that occurs in the early months of life in healthy children. Case report. We reported two patients with BPT. In the first patient the symptoms were observed at the age of day 20, and disappeared at the age of 3 years. There were 10 episodes, of which 2 were followed by vomiting, pallor, irritability and the abnormal trunk posture. In the second patient, a 12-month-old girl, BPT started from day 15. She had 4 episodes followed by vomiting in the first year. Both girls had the normal psychomotor development. All diagnostical tests were normal. Conclusion. The recognition of BPT, as well as its clinical course may help to avoid not only unnecessary tests and the treatment, but also the anxiety of the parents.

  6. Benign fibroxanthoma of the mandible

    Directory of Open Access Journals (Sweden)

    L Zouloumis


    Full Text Available Histiocytomas constitute a large group of tumors, the classification of which created a lot of confusion in the past. For this reason, various attempts were carried out during the last years so that a widely accepted classification system could be defined. Fibroxanthomas, according to contemporary data, are classified into benign histiocytomas and they are mostly located at the skin of extremities. They are rarely localized in the area of the head and neck, where they are found commonly in soft tissue. Fibroxanthomas located at the bones of oral and maxillofacial region are extremely rare. The purpose of this paper is to present a case of a fibroxanthoma located at the mandible as well as to analyze the histological findings of the lesion on which the diagnosis and differential diagnosis were based.

  7. The frequency of benign prostate hypertrophy in Calabar. (United States)

    Umezurike, B I; Ekanem, T B; Eluwa, M A; Etta, K K; Udo-Affah, G A; Aligwekwe, A U


    The present study was to find out through histopathological records the most frequently occurring disease of the prostate from suspected prostate diseases in Calabar, Cross River State, Nigeria. A total number of 324 cases of prostatic biopsies and autopsy materials recorded in the histopathology laboratory of the University of Calabar Teaching Hospital (UCTH), Calabar between 1986 and 1995 were used for this study. Benign prostatic hypertrophy was observed as the major pathology among all the diseases of the prostate gland recorded in UCTH in Calabar having accounted for 76.3% (261 out of 342) while prostatic carcinoma accounted for 19% (65 out of 324), rest 4.7% (16 out of 342) were inflammatory lesions. The result indicated that benign prostatic hypertrophy occurs in men from 40 years and above. The frequency increased with age, reaching a maximum of 34.5% (90 out of 261) in the age group (70-79) years old. The people in Cross River State should be informed of the high frequency of benign prostatic hypertrophy and should be advised to seek health care promptly in suspected prostate related illness.

  8. Benign cystic mesothelioma of the appendix presenting in a woman: a case report

    LENUS (Irish Health Repository)

    O' Connor, Donal B


    Abstract Introduction Benign cystic mesothelioma or peritoneal inclusion cysts are rare benign abdominal tumors usually occurring in females of reproductive age. These cysts present as abdominopelvic pain or masses but are often found on imaging or incidentally at surgery. They are commonly associated with pelvic inflammatory disease, endometriosis, or ovarian cysts. We report what is, to the best of our knowledge, the first case of a benign cystic mesothelioma complicating a presentation of acute appendicitis. Case Presentation A 19-year-old Irish Caucasian woman presented with abdominal pain. Imaging suggested appendicitis with abscess formation. She was treated with antibiotics and scheduled for interval appendicectomy. At laparoscopy, an unusual cystic mass was found arising from the appendix. Histology revealed benign cystic mesothelioma. Conclusion We report what is, to the best of our knowledge, the first case of a benign cystic mesothelioma arising from the appendix and complicating a presentation of acute appendicitis. This is a benign pathology, but recurrences are not uncommon. Benign cystic mesothelioma should be included in the differential when investigating pelvic masses or abscesses associated with either appendicitis or pelvic inflammatory disease in women.

  9. Will patients benefit from regionalization of gynecologic cancer care?

    Directory of Open Access Journals (Sweden)

    Kathleen F Brookfield

    Full Text Available OBJECTIVE: Patient chances for cure and palliation for a variety of malignancies may be greatly affected by the care provided by a treating hospital. We sought to determine the effect of volume and teaching status on patient outcomes for five gynecologic malignancies: endometrial, cervical, ovarian and vulvar carcinoma and uterine sarcoma. METHODS: The Florida Cancer Data System dataset was queried for all patients undergoing treatment for gynecologic cancers from 1990-2000. RESULTS: Overall, 48,981 patients with gynecologic malignancies were identified. Endometrial tumors were the most common, representing 43.2% of the entire cohort, followed by ovarian cancer (30.9%, cervical cancer (20.8%, vulvar cancer (4.6%, and uterine sarcoma (0.5%. By univariate analysis, although patients treated at high volume centers (HVC were significantly younger, they benefited from an improved short-term (30-day and/or 90-day survival for cervical, ovarian and endometrial cancers. Multivariate analysis (MVA, however, failed to demonstrate significant survival benefit for gynecologic cancer patients treated at teaching facilities (TF or HVC. Significant prognostic factors at presentation by MVA were age over 65 (HR = 2.6, p<0.01, African-American race (HR = 1.36, p<0.01, and advanced stage (regional HR = 2.08, p<0.01; advanced HR = 3.82, p<0.01, respectively. Surgery and use of chemotherapy were each significantly associated with improved survival. CONCLUSION: No difference in patient survival was observed for any gynecologic malignancy based upon treating hospital teaching or volume status. Although instances of improved outcomes may occur, overall further regionalization would not appear to significantly improve patient survival.

  10. Benign breast lesions detected by positron emission tomography-computed tomography

    Energy Technology Data Exchange (ETDEWEB)

    Benveniste, Ana P., E-mail: [Department of Diagnostic Radiology,The University of Texas MD Anderson Cancer Center, Houston, TX (United States); Yang, Wei, E-mail: [Department of Diagnostic Radiology,The University of Texas MD Anderson Cancer Center, Houston, TX (United States); Benveniste, Marcelo F., E-mail: [Department of Diagnostic Radiology,The University of Texas MD Anderson Cancer Center, Houston, TX (United States); Mawlawi, Osama R., E-mail: [Department of imaging physics, The University of Texas MD Anderson Cancer Center, Houston, TX (United States); Marom, Edith M., E-mail: [Department of Diagnostic Radiology,The University of Texas MD Anderson Cancer Center, Houston, TX (United States)


    {sup 18}F-fluorodeoxyglucose positron emission computed tomography (FDG PET-CT) is widely used in the initial staging and response evaluation of patients with malignancy. This review describes a spectrum of benign breast findings incidentally detected by FDG PET-CT at staging that may be misinterpreted as malignancy. We describe the pattern of distribution and intensity of FDG uptake in a spectrum of benign breast diseases with their corresponding typical morphological imaging characteristics to help the nuclear medicine physician and/or general radiologist identify benign lesions, avoiding unnecessary breast imaging work-up and biopsies.

  11. Baseline characteristics influencing quality of life in women undergoing gynecologic oncology surgery

    Directory of Open Access Journals (Sweden)

    Jenison Eric L


    Full Text Available Abstract Background Quality of life (QoL measurements are important in evaluating cancer treatment outcomes. Factors other than cancer and its treatment may have significant effects on QoL and affect assessment of treatments. Baseline data from longitudinal studies of women with endometrial or ovarian cancer or adnexal mass determined at surgery to be benign were analyzed to determine the degree to which QoL is affected by baseline differences in demographic variables and health. Methods This study examined the effect of independent variables on domains of the Functional Assessment of Cancer Therapy (FACT-G pre-operatively in gynecologic oncology patients undergoing surgery for pelvic mass suspected to be malignant or endometrial cancer. Patients also completed the Short Form Medical Outcomes Survey (SF-36 questionnaire (a generic health questionnaire that measures physical and mental health. Independent variables were surgical diagnosis (ovarian or endometrial cancer, benign mass, age, body mass index (BMI, educational level, marital status, smoking status, physical (PCS and mental (MCS summary scores of the SF-36. Multiple regression analysis was used to determine the influence of these variables on FACT-G domain scores (physical, functional, social and emotional well-being. Results Data were collected on 157 women at their pre-operative visit (33 ovarian cancer, 45 endometrial cancer, 79 determined at surgery to be benign. Mean scores on the FACT-G subscales and SF-36 summary scores did not differ as a function of surgical diagnosis. PCS, MCS, age, and educational level were positively correlated with physical well-being, while increasing BMI was negatively correlated. Functional well-being was positively correlated with PCS and MCS and negatively correlated with BMI. Social well-being was positively correlated with MCS and negatively correlated with BMI and educational level. PCS, MCS and age were positively correlated with emotional well

  12. Transphyseal spread of benign tumors and infections in pediatric patients: A series of six cases

    Directory of Open Access Journals (Sweden)

    Bagaria Vaibhav


    Full Text Available Epiphyseal extension of benign pathology is regarded as an infrequent occurrence. This observation has been attributed to anatomical and biochemical phenomenon unique to physeal cartilage. We report a retrospective series of six patients over a period of 4 years, diagnosed with benign pathologies that showed crossing of an open physeal plate by the disease. Four of these cases were infections and two were benign tumors. The patients were aged between 5 and 11 years, all of them were treated at a tertiary referral centre and followed up for a minimum period of 6 months to evaluate the progress of disease. The findings are more than just a pathological curiosity as they alter the management and surgical procedure that needs to be performed for these conditions. The recognition of the fact that benign tumors may occasionally present with transphyseal spread will prevent unjustified radical procedures that are best reserved for aggressive malignant conditions.

  13. Comparison among Minor Invasive Surgical Approaches to Hysterectomy for Benign Gynecological Diseases: A Systematic Review and Meta-analysis%良性疾病全子宫切除术不同微创术式间比较的系统评价

    Institute of Scientific and Technical Information of China (English)

    黄志华; 屠蕊沁; 吴利俊


    目的 比较和评价阴式全子宫切除术(total vaginal hysterectomy,TVH)、腹腔镜全子宫切除术(Lapros-copical hyterectomy,LH)、横切口开腹全子宫切除术(minilaporotomy hysterectomy,MiniLPT)等不同微创全子宫切除术式的效果及安全性,以指导临床选择最合理的术式.方法 检索CBM、中国期刊全文数据库、万方数据资源系统、MEDLINE、EMbase、CochraneDSR、ACP Journal Club、DARE、CCTR、CMR、HTA、和NHSEED等数据库中关于比较TVH、LH、MiniLPT术式中至少两种的随机对照试验、比较性研究、经济评价,罕见结局的报道可包括观察性研究.检索截止时间为2009年3月.采用GRADE标准及Cochrane Reviewer Handbook 4.2.3对RCT的质量评价标准进行评价.用Cochrane协作网提供的RevMan 4.2软件进行Meta分析.结果 最终纳入12个研究,包括10个随机对照试验,1个回顾性队列研究、1个前瞻性队列研究.Meta分析结果显示TVH组手术时间最短、出血量最少、术后疼痛最轻、恢复排便或者排气最快、出院最早.MiniLPT组术后住院时间比对照组(TVH/LAVH组)长,差异有统计学意义[WMD=37.0h,95%CI(13.5h,60.5h)];MiniLPT组术中出血量比对照组多,差异有统计学意义[WMD=208.5ml,95%CI(141.4ml,375.7ml)],MiniLPT组发热发生率比对照组高,差异有统计学意义[PetoOR=3.8,95%CI(1.1,12.6). TVH组手术时间比LH组短,差异有统计学意义[WMD=47.2min,95%CI(-62.3min,32.19min)];TVH组出血量比LAVH组少,差异有统计学意义[WMD=-158.7ml,95%CI(-190.9 ml,-126.4ml)];TVH组住院时间比LH组短,差异有统计学意义[WMD=-18.8 h,95%CI(-24.2 h,-13.5 h)];TVH组术后恢复排气或排便时间比LAVH组短,差异有统计学意义[WMD=8.1 h,95%CI(-10.8 h,-5.3 h)].另一方面,LH组创面缝合愈合不良事件发生率、继发感染发生率、发热发生率均比TVH组低,但差异无统计学意义.LH组比TVH组术后性功能质量更好.结论 在基本符合TVH适应证的情况下,TVH是最微创的手术方式,且性价比高.在TVH适应证以外,只要在可以操作的范围内,TVH仍然是创伤最小且效果最好的手术方式,但这一范围目前尚无统一标准,跟术者经验水平、手术习惯和患者具体情况相关.LH在改善术后生活质量、患者自我感觉方面较为优越.通过提高腹腔镜手术止血技巧减少术中出血量,减少一次性器具费用或其使用、增加其回收,可降低手术费用,并可以提高LH性价比.MiniLPT发展时间尚短,相关比较研究起步也晚,其优越性有待更多研究进一步评估.

  14. Gynecologic Cancer Information on YouTube: Will Women Watch Advertisements to Learn More? (United States)

    Cooper, Crystale Purvis; Gelb, Cynthia A; Chu, Jennifer


    The quality and accuracy of health content posted on YouTube varies widely. To increase dissemination of evidence-based gynecologic cancer information to US YouTube users, the Centers for Disease Control and Prevention (CDC) sponsored two types of advertisements: (1) pre-roll videos that users had to watch for at least 5 s before seeing a video they selected and (2) keyword-targeted listings that appeared in search results when users entered terms related to gynecologic cancer. From July 2012 to November 2013, pre-roll videos were shown 9.2 million times, viewed (watched longer than the mandatory 5 s) 1.6 million times (17.6 %), and cost $0.09 per view. Keyword-targeted listings were displayed 15.3 million times, viewed (activated by users) 59,766 times (0.4 %), and cost $0.31 per view. CDC videos in advertisements played completely in 17.0 % of pre-roll video views and 44.4 % of keyword-targeted listing views. Advertisements on YouTube can disseminate evidence-based cancer information broadly with minimal cost.

  15. Current status of benign breast diseases and metabolic syndrome in professional women in Chongqing and study on relative risk factors%重庆市职业女性乳腺良性疾病和代谢性疾病患病现状及相关危险因素研究

    Institute of Scientific and Technical Information of China (English)

    冉亮; 龚涛; 王永红; 罗蓉; 张明军; 邓学洁; 屈小英


    目的 探讨重庆市职业女性乳腺良性疾病和代谢综合征患病现状及其相关危险因素.方法 随机整群抽样,调查重庆市2 604名职业女性.胆固醇氧化酶法等测定血脂等生化指标,体检测定身高、体重等指标.卡方检验、多因素Logistic回归计分析.结果 乳腺良性疾病、代谢综合征、高血糖、高血压、血脂紊乱和超重肥胖总的患病率分别为19.27% (429/2 226)、7.91%( 176/2 226)、8.04%( 179/2 226)、23.23% (517/2 226)、24.21% (539/2 226)和20.5% (457/2 226).不同职业及不同年龄段的乳腺良性疾病患病率之间比较,其差异有统计学意义(P<0.01).公司文职人员和公务员乳腺良性疾病患病率较高,30 ~ 39岁组女性乳腺良性疾病患病率较高.年龄与乳腺良性疾病呈负相关.乳腺良性疾病与代谢综合征无相关性.结论 重庆市职业女性人群乳腺良性疾病和代谢综合征患病率较高.建议职业女性定期做乳腺自检或专科检查,以利早诊治.%Objective To study current status of benign breast diseases and metabolic syndrome in professional women in Chongqing and relative risk factors. Methods Professional women (2604 cases ) in Chongqing were surveyed by random cluster sampling.The biochemical indicators such as blood lipid were determined by cholesterin oxidase.The indicators such as height and weight were measured by physical examination.Chi-square test and logistic regression were used in statistical analysis. Results The morbidity rate of benign breast diseases, metabolic syndrome, hyperglycaemia, hypertension, hyperlipidemia, and obesity in our study was 19.27% (429/2226), 7.91% ( 176/2226 ), 8.04% ( 179/2226 ), 23.23% ( 517/2226 ), 24.21% ( 539/2226 ) and 20.5% (457/2226) respectively.The difference of mobidity rate between different age group and different career had statistical significance.Office workers and civil servants were high risk population.Age was

  16. Nocturia and benign prostatic hyperplasia

    Directory of Open Access Journals (Sweden)

    Laketić Darko


    Full Text Available Background/Aim. Nocturia often occurs in patients with benign prostate hyperplasia (BPH. The aim of the study was to investigate the frequency of nocturia in patients with BPH. Nocturia and other factors associated with it were also investigated. Methods. Forty patients with the confirmed diagnosis of BPH were studied. Transurethral and transvesical prostatectomy were performed in all the patients. Symptoms were evaluated with the International Prostate Symptom Score before, as well as three and six months after the surgery. All the results were compared with the control group. Results. There was no statistically significant difference between the patients before and after the surgery regarding nocturia. There was, however, a statistically significant difference between the operated patients and the control group regarding nocturia, as well as a statistically significant correlation between noctruia and the age of the patients in both the investigated and the control group. A correlation also existed between nocturia and the prostatic size. Conclusion. There was no statistically significant improvement in symptoms of nocturia after the surgery. It is necessary to be very careful in decision making in patients with nonabsolute indiction for surgery and isolated bothersome symptom of nocturia. Age of a patient should also be considered in the evaluation of favorable result of the surgery because of a significant correlation between noctura and the age of a patient.

  17. Benign Paroxysmal Positional Vertigo: An Integrated Perspective

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    Kourosh Parham


    Full Text Available Benign paroxysmal positional vertigo (BPPV, the most common cause of dizziness, occurs in all age groups. It presents with vertigo on head movement, but in older patients presentation may be typical and thus accounting for a low recognition rate in the primary care setting. It may be recurrent in up to 50% of cases. BPPV is associated with displacement of fragments of utricular otoconia into the semicircular canals, most commonly the posterior semicircular canal. Otoconia are composed of otoconin and otolin forming the organic matrix on which calcium carbonate mineralizes. Otoconia may fragment with trauma, age, or changes in the physiology of endolymph (e.g., pH and calcium concentration. Presentation varied because otoconia fragments can be displaced into any of the semicircular canals on either (or both side and may be free floating (canalolithiasis or attached to the cupula (cupulolithiasis. Most cases of BPPV are idiopathic, but head trauma, otologic disorders, and systemic disease appear to be contributory in a subset. Positional maneuvers are used to diagnose and treat the majority of cases. In rare intractable cases surgical management may be considered. A strong association with osteoporosis suggests that idiopathic BPPV may have diagnostic and management implications beyond that of a purely otologic condition.

  18. Clinical Investigation of Benign Asbestos Pleural Effusion. (United States)

    Fujimoto, Nobukazu; Gemba, Kenichi; Aoe, Keisuke; Kato, Katsuya; Yokoyama, Takako; Usami, Ikuji; Onishi, Kazuo; Mizuhashi, Keiichi; Yusa, Toshikazu; Kishimoto, Takumi


    There is no detailed information about benign asbestos pleural effusion (BAPE). The aim of the study was to clarify the clinical features of BAPE. The criteria of enrolled patients were as follows: (1) history of asbestos exposure; (2) presence of pleural effusion determined by chest X-ray, CT, and thoracentesis; and (3) the absence of other causes of effusion. Clinical information was retrospectively analysed and the radiological images were reviewed. There were 110 BAPE patients between 1991 and 2012. All were males and the median age at diagnosis was 74 years. The median duration of asbestos exposure and period of latency for disease onset of BAPE were 31 and 48 years, respectively. Mean values of hyaluronic acid, adenosine deaminase, and carcinoembryonic antigen in the pleural fluid were 39,840 ng/mL, 23.9 IU/L, and 1.8 ng/mL, respectively. Pleural plaques were detected in 98 cases (89.1%). Asbestosis was present in 6 (5.5%) cases, rounded atelectasis was detected in 41 (37.3%) cases, and diffuse pleural thickening (DPT) was detected in 30 (27.3%) cases. One case developed lung cancer (LC) before and after BAPE. None of the cases developed malignant pleural mesothelioma (MPM) during the follow-up.

  19. Clinical Investigation of Benign Asbestos Pleural Effusion

    Directory of Open Access Journals (Sweden)

    Nobukazu Fujimoto


    Full Text Available There is no detailed information about benign asbestos pleural effusion (BAPE. The aim of the study was to clarify the clinical features of BAPE. The criteria of enrolled patients were as follows: (1 history of asbestos exposure; (2 presence of pleural effusion determined by chest X-ray, CT, and thoracentesis; and (3 the absence of other causes of effusion. Clinical information was retrospectively analysed and the radiological images were reviewed. There were 110 BAPE patients between 1991 and 2012. All were males and the median age at diagnosis was 74 years. The median duration of asbestos exposure and period of latency for disease onset of BAPE were 31 and 48 years, respectively. Mean values of hyaluronic acid, adenosine deaminase, and carcinoembryonic antigen in the pleural fluid were 39,840 ng/mL, 23.9 IU/L, and 1.8 ng/mL, respectively. Pleural plaques were detected in 98 cases (89.1%. Asbestosis was present in 6 (5.5% cases, rounded atelectasis was detected in 41 (37.3% cases, and diffuse pleural thickening (DPT was detected in 30 (27.3% cases. One case developed lung cancer (LC before and after BAPE. None of the cases developed malignant pleural mesothelioma (MPM during the follow-up.

  20. Treating benign prostatic hyperplasia with botulinum neurotoxin. (United States)

    Brisinda, G; Vanella, S; Marniga, G; Crocco, A; Maria, G


    Botulinum toxin (BoNT) has been increasingly used in the interventional treatment of several disorders; the use of this agent has extended to a plethora of conditions including focal dystonia, spasticity, inappropriate contraction in most gastrointestinal sphincters, eye movement disorders, hyperhidrosis, genitourinary disorders and aesthetically undesirable hyperfunctional facial lines. In addition, BoNT is being investigated for the control of pain, and for the management of tension or migraine headaches and myofascial pain syndrome. Benign prostatic hyperplasia (BPH) is a common condition in ageing men; the goal of therapy is to reduce the lower urinary tract symptoms (LUTS) associated with BPH and to improve the quality of life. However, medical treatment, including drugs that relax smooth muscle within the prostate and drugs that shrink the gland are not totally effective or without complications. The standard surgical treatment for BPH is progressively changing to minimally invasive therapies, but none of them has provided clear results. The use of BoNT-A to inhibit the autonomic efferent effects on prostate growth and contraction, and inhibit the abnormal afferent effects on prostate sensation, might be an alternative treatment for BPH. BoNT injections have several advantages over drugs and surgical therapies in the management of intractable or chronic disease; systemic pharmacologic effects are rare, permanent destruction of tissue does not occur, and graded degrees of relaxation may be achieved by varying the dose injected. In this paper, clinical experience over the last years with BoNT in BPH impaired patients will be illustrated.


    Directory of Open Access Journals (Sweden)



    Full Text Available Benign intracranial hypotension, otherwise called as idiopathic intracranial hypotension is caused by CSF leaks due to disruption in spinal meninges. It is most commonly caused by disruption and leak at cervical and thoracic spine. Imaging is sometimes the most important key to the diagnosis of idiopathic intracranial hypotension, which helps in appropriate treatment of the patient. Here, we are presenting a case of benign intracranial hypotension associated with incidental parasagittal meningioma. The presence of benign intracranial hypotension was confirmed by taking MR myelogram.

  2. Designing a Standardized Laparoscopy Curriculum for Gynecology Residents

    DEFF Research Database (Denmark)

    Shore, Eliane M; Lefebvre, Guylaine G; Husslein, Heinrich


    surgery, and asked 39 experts in gynecologic education to rate the items on a Likert scale (1-5) for inclusion in the curriculum. Consensus was predefined as Cronbach α of ≥0.80. We then conducted another Delphi survey with 9 experienced users of laparoscopic virtual reality simulators to delineate...... of the curriculum Delphi, and after 2 rounds (Cronbach α=0.80) in the virtual reality curriculum Delphi. Consensus was reached for cognitive, technical, and nontechnical skills as well as for 6 virtual reality tasks. Median time and economy of movement scores defined benchmarks for all tasks. CONCLUSIONS......: This study used Delphi consensus to develop a comprehensive curriculum for teaching gynecologic laparoscopy. The curriculum conforms to current educational standards of proficiency-based training, and is suggested as a standard in residency programs....

  3. The clinical characteristics of the benign paroxysmal positional vertigo associated with Meniere's disease%继发梅尼埃病良性阵发性位置性眩晕的临床特点

    Institute of Scientific and Technical Information of China (English)

    李鹏; 曾祥丽; 李永奇; 张革化; 叶进


    Objective To explore the clinical characteristics of the benign paroxysmal positional vertigo (BPPV) associated with Meniere's disease (MD) in retrospect in an effort to improve the diagnosis and efficacy of treatment Method Fifteen cases (1 male and 14 female, aged 46 to 68 years old) of BPPV associated with MD from July 2007 to June 2009 were retrospectively analyzed. Patient clinically characterized with positional paroxysmal vertigo were diagnosed as MD by ECochG and glycerol test and were confirmed as BPPV associated with MD by Dix Hallpike test or roll test They were treated with Epley maneuver or Barbecue rol maneuver according to the type of BPPV, and the efficacy was evaluated. Result (1) Most cases involved female patients in this study; (2) BPPV occurred after MD in al of the cases, of which 13 cases were posterior semicircular canal lithiasis (9 cases in the same ear, 2 in the other and 2 in both) and 2 cases were horizontal semicircula canal lithiasis (cupula lithiasis in the same ear) ; (3) in this study, 10 patients were cured after 3-4 times of posture treatment (66.7% ), 4 patients were cured after 5 times and 1 patient received endolymphatic sac decompression because of recurrent vertigo. Conclusion (1) BPPV can result from MD, for which a possible mechanism may be the hydrolabyrinth that lead to eardust falling off. (2) Most cases of BPPV occurred in the posterior semicircular canal in the same ear. Most cases in incidence rate have obvious sexual bias in female. (3) Eardust reposition is an effective treatment for BPPV caused by MD; while it is refractory compared to ordinary BPPV and requiremultiple treatments, which may be related to the recurrence of hydrolabyrinth.%目的 回顾性分析继发于梅尼埃病(MD)的良性阵发性位置性眩晕(BPPV)的临床特点,并探讨该病的诊断与治疗特点.方法 自2007年7月至2009年6月于中山大学附属第三医院入院的梅尼埃病伴BPPV患者15例,男1例,女14例;年龄46~69

  4. Well-leg compartment syndrome after gynecological laparoscopic surgery

    DEFF Research Database (Denmark)

    Boesgaard-Kjer, Diana H; Boesgaard-Kjer, Daniel; Kjer, Jens Jørgen


    Well-leg compartment syndrome in the lower extremities after surgery in the lithotomy position is a rare but severe complication requiring early diagnosis and intervention. Several circumstances predispose to this condition as a consequence of increased intra-compartmental pressure, such as posit....... Potential risk factors and preventive initiatives are listed to reduce the risk in future patients. We describe two patients who underwent gynecologic laparoscopic surgery and postoperatively developed well-leg compartment syndrome....

  5. Copper-vapor laser in medical practice: gynecology (United States)

    Chvykov, Vladimir V.; Zazulya, O. I.; Zemskov, Konstantin I.


    About 100 patients were treated for cervical erosion, cervical leukoplakia, and vulval warts in the Gynecology Department of the adult polyclinic of the Zelenograd Center of Medicine. Copper vapor laser (CVL) was used with output average power up to 4 W in two lines (510 nm, 578 nm). Pulse repetition rate was about 10 kHz, pulselength approximately 20 - 40 ns. Four to twelve procedures were sufficient to recover.

  6. OCT in difficult diagnostic cases in gynecology (United States)

    Panteleeva, Olga; Shakhova, Natalia; Gelikonov, Grigory; Yunusova, Ekaterina


    The study is aimed at developing new methods for diagnosing causes of impairment of female reproductive function. An increase of infertility and chronic pelvic pains syndrome, a growing level of latent diseases of this group, as well as a stably high percentage (up to 25% for infertility and up to 60% for the chronic pelvic pains syndrome) of undetermined origin make this research extremely important. As a complementary technique to laparoscopy we propose to use optical coherence tomography. We have acquired OCT images of different parts of fallopian tubes and pelvic peritoneum and analyzed OCT criteria of unaltered tissues. The OCT images of the isthmic part of fallopian tubes and peritoneum have been morphologically verified for pelvic inflammatory diseases (PID) and endometriosis. Changes in the optical properties of the studied organs typical of PID and endometriosis have been investigated. Based on comparative analysis of the OCT data and the results of histological studies OCT criteria of the considered diseases have been developed. Statistical analysis of diagnostic efficacy of OCT in the case of PID has been carried out. High (75-85%) diagnostic accuracy of OCT in PID is shown.

  7. The epidemiologic status of gynecologic cancer in Thailand. (United States)

    Wilailak, Sarikapan; Lertchaipattanakul, Nuttapong


    Between the years of 2010-2012, it was estimated there were a total of 112,392 new cases of cancers in Thailand, thus, the total age-standardized rate (ASR) per 100,000 is 137.6. In regards to the most prevalent types of cancer in female, breast cancer has the highest ASR, followed by cervical cancer (ASR=14.4); liver and bile duct cancer; colon and rectum cancer; trachea, bronchus and lung cancer; ovarian cancer (ASR=6.0); thyroid cancer; non-Hodgkin lymphoma and uterine cancer (ASR=4.3). The trend of cervical cancer in Thailand is decreasing, one key factor in making this possible was the employment of dual tract strategy (Pap smear and visual inspection with acetic acid [VIA]) by the government in 2005. In the future, the government is also considering integrating human papillomavirus (HPV) vaccination into the national immunization program, which may assist in the prevention of cervical cancer. By studying the statistical data of gynecologic cancer, it will be possible to formulate measures for the prevention, control and treatment of gynecologic cancer. Eventually, it will potentially improve the quality of life (QoL) of patients as well as decrease the mortality rate caused by gynecologic cancer.

  8. Horizontal Canal Benign Positional Vertigo

    Directory of Open Access Journals (Sweden)

    Mohtaram Najafi


    Full Text Available Benign paroxysmal positional vertigo (BPPV is a syndrome characterized by transient episodes of vertigo in association with rapid changes in head position in Dix-Halpike Maneuver. This kind of vertigo is thought to be caused by migration of otoconial debris into canals other than the posterior canal, such as the anterior or lateral canals. It is also theoretically possible for many aberrant patterns of BPPV to occur from an interaction of debris in several canals, location of debris within the canal, and central adaptation patterns to lesions. The symptoms of BPPV are much more consistent with free-moving densities (canaliths in the posterior SCC rather than fixed densities attached to the cupula. While the head is upright, the particles sit in the PSC at the most gravity-dependent position. The best method to induce and see vertigo and nystagmus in BPPV of the lateral semicircular canal is to rotate head 90°while patient is in the supine position, nystagmus would appear in the unaffected side weaker but longer than the affected side. canal paresis has been described in one third of the patients with BPPV. Adaptation which is one of the remarkable features of BPPV in PSC is rarely seen in LSC. Rotations of 270° or 360° around the yaw axis (the so-called barbecue maneuver toward the unaffected ear are popular methods for the treatment of geotropic HC-BPPV. These maneuvers consist of sequential head turning of 90° toward the healthy side while supine. With these maneuvers, the free-floating otoconial debris migrates in the ampullofugal direction, finally entering the utricle through the nonampullated end of the horizontal canal. This kind of vertigo recovers spontaneously more rapidly and suddenly.

  9. Lipomatosis simétrica benigna tipo II (Enfermedad de Madelung: a propósito de un caso Type II benign symmetric lipomatosis (Madelung"s disease: case report

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    C. León Llerena


    Full Text Available Presentamos el caso de un varón de 56 años de edad con historia de 35 años de abuso de alcohol y sin otra patología asociada, que presentaba masas en hombros, mamas y flancos que habían aumentado de tamaño de forma progresiva durante los últimos dos años y medio, y que dificultaban su movilidad y su actividad laboral. El estudio mediante Tomografía Axial Computerizada apreció un exceso de deposito graso de distribución homogénea no encapsulado (difuso sobre los hombros, mamas y cintura abdominal, sin afectación de estructuras profundas. Consideramos importante conocer los dos tipos existentes de Lipomatosis Simétrica Benigna, por sus diferencias tanto en la localización de las masas lipomatosas como en la afectación de estructuras profundas. Es por ello que aportamos este caso de Lipomatosis Simétrica Benigna tipo II sin afectación cervical ni de estructuras profundas.We report the case of a 56 years-old man with a 35-years history of alcohol abuse, but no other illness. The patient presented masses on shoulders, breasts and flanks that had enlarged progressively over the previous two and a half years, and that hindered his work by restricting mobility. Computed Tomography revealed non-encapsulated excess fat deposits evenlydistributed on shoulders, breasts and abdomen, without affecting the deep structures. Awareness of the two types of Benign symmetric lipomatosis is necessary because of their differences, both in location of the lipomatous masses and in the involvement of the deep structures. We therefore report this case of type II Benign symmetric lipomatosis without cervical or deep structure involvement.

  10. Migraine with benign episodic unilateral mydriasis

    Directory of Open Access Journals (Sweden)

    Jabr FI


    Full Text Available Nedaa Skeik1, Fadi I Jabr21Mayo Clinic, Rochester, MN, USA; 2Horizon Medical Center, Hospital Medicine, Dickson, TN, USAAbstract: Pupil asymmetry or anisocoria can have benign or malignant causes, and be categorized as acute or chronic. It can also be a normal finding in about 20% of cases. Benign episodic unilateral mydriasis is an isolated benign cause of intermittent pupil asymmetry. The exact pathophysiology is not always understood. According to one hypothesis, it is due to discordance between the sympathetic and parasympathetic systems. It is occasionally seen in patients with migraine. Some authors consider it a limited form of ophthalmoplegic migraine. We report a case of benign episodic unilateral mydriasis diagnosed in a 30-year-old lady with a history of migraine who had extensive negative neurological evaluation.Keywords: anisocoria, migraine, unilateral episodic mydriasis

  11. Genetics Home Reference: benign familial neonatal seizures (United States)

    ... Facebook Share on Twitter Your Guide to Understanding Genetic Conditions Search MENU Toggle navigation Home Page Search ... Conditions Genes Chromosomes & mtDNA Resources Help Me Understand Genetics Home Health Conditions BFNS benign familial neonatal seizures ...

  12. Oromotor Dyspraxia in Benign Childhood Epilepsy


    J Gordon Millichap


    A six year old right handed boy with prolonged intermittent drooling, oromotor dyspraxia, and benign childhood epilepsy with centrotemporal spikes is reported from the Departments of Pediatrics and Neurology, Centre Hospitalier, Universitaire Vaudois, Lausanne, Switzerland.

  13. Genetics Home Reference: benign recurrent intrahepatic cholestasis (United States)

    ... All Close All Description Benign recurrent intrahepatic cholestasis (BRIC) is characterized by episodes of liver dysfunction called ... a lack of appetite. A common feature of BRIC is the reduced absorption of fat in the ...

  14. Oral benign fibrous histiocytoma: two case reports


    Menditti, Dardo; Laino, Luigi; Mezzogiorno, Antonio; Sava, Sara; Bianchi, Alexander; Caruso, Giovanni; Di Maio, Luigi; Baldi, Alfonso


    Fibrous histiocytoma is a benign soft tissue tumour arising as a fibrous mass everywhere in the human body. The involvement of the oral cavity is rare. We report two cases of benign fibrous histiocytoma that localized in the oral cavity. The clinical and histological features of the lesion are reported. Finally, a literature revision of this pathology at the level of the oral cavity is reported.

  15. Ectopic pregnancy: a life-threatening gynecological emergency

    Directory of Open Access Journals (Sweden)

    Lawani OL


    Full Text Available Osaheni L Lawani, Okechukwu B Anozie, Paul O Ezeonu Department of Obstetrics and Gynecology, Federal Teaching Hospital, Abakaliki, Nigeria Background: Ectopic pregnancy is a life-threatening gynecological emergency, and a significant cause of maternal morbidity and mortality in Nigeria. Objective: The aim of this work was to determine and evaluate the incidence, clinical presentation, risk factors, and management outcomes of ectopic pregnancies at Ebonyi State University Teaching Hospital (EBSUTH in Abakaliki. Methods: This was a retrospective, descriptive study of ectopic pregnancies managed in EBSUTH during the study period (June 1, 2002 to May 31, 2012. The medical records of the patients managed for ectopic pregnancy as well as the total birth record and gynecological admission records during the period under review were retrieved, and data were collected with the aid of data-entry forms designed for this purpose. There were 4,610 gynecological admissions and 9,828 deliveries, with 215 cases of ectopic pregnancies. A total of 205 cases were suitable for analysis after excluding cases with incomplete records. The relevant data collected were analyzed with SPSS version 15.0 for Windows. Results: Ectopic pregnancy constituted 4.5% of all gynecological admissions, and its incidence was 2.1%. The mean age of the patients was 27 ± 2 years, 196 of 205 (95.6% had ruptured ectopic pregnancies, and the remaining nine (4.4% were unruptured. The commonest (166 of 205, 80.0% clinical presentation was abdominal pain, and the commonest (105 of 205, 51.2% identified risk factor was a previous history of induced abortion. Three deaths were recorded, giving a case-fatality rate of 1.4% (three of 205. Conclusion: Ectopic pregnancy is a recognized cause of maternal morbidity and mortality and has remained a reproductive health challenge to Nigerian women, as well as a threat to efforts in achieving the UN's Millennium Development Goal 5 in sub-Saharan Africa

  16. Benign nontraumatic osteolytic vertebral collapse simulating malignancy

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    Sattari, Azadeh [Hopital Lariboisiere, Department of Musculoskeletal Radiology, Paris Cedex 10 (France); Quillard, Alain [Hopital Lariboisiere, Department of Pathology, Paris Cedex 10 (France); Laredo, Jean-Denis [Hopital Lariboisiere, Department of Musculoskeletal Radiology, Paris Cedex 10 (France); University of Pennsylvania Health System, Department of Radiology, Philadelphia, PA (United States)


    This study described the imaging features of a distinctive pattern of biopsy-proven benign non-traumatic vertebral collapse (VC) that can mimic malignancy. Among 240 patients referred with painful VC over a 10-year period, we retrospectively selected 15 cases of benign VC which simulated malignancy, due to cortical bone destruction on radiographs. The diagnosis of benign origin was documented by percutaneous biopsy and 12-months of follow-up. Radiographs, CT and MR images of the spine were reviewed. Findings suggestive of malignancy included destruction involving the anterolateral cortex, posterior cortex and pedicles of the vertebral body (46%,15% and 15% respectively) at CT, epidural soft-tissue masses on CT (23%) and MR images (21%), and diffuse low signal-intensity (SI) of the vertebral body (50%) and pedicles (79%) on T1-weighted images. Features suggestive of a benign origin included an intravertebral vacuum phenomenon on radiographs and CT (13%), fracture lines within the vertebral body (92%) or pedicles (62%) at CT and presence an intravertebral area of high SI on T2-weighted images (93%). Benign non-traumatic osteolytic VC can simulate malignancy on radiographs. The features, above mentioned on CT and MR suggestive of a benign VC, are useful in interpreting biopsy results of such lesions and avoiding unnecessary repeat biopsy. (orig.)

  17. To the point: obstetrics and gynecology global health experiences for medical students. (United States)

    Hampton, Brittany S; Chuang, Alice W; Abbott, Jodi F; Buery-Joyner, Samantha D; Cullimore, Amie J; Dalrymple, John L; Forstein, David A; Hueppchen, Nancy A; Kaczmarczyk, Joseph M; Page-Ramsey, Sarah; Pradhan, Archana; Wolf, Abigail; Dugoff, Lorraine


    This article, from the To the Point series prepared by the Association of Professors of Gynecology and Obstetrics Undergraduate Medical Education Committee, provides educators with an overview of considerations for obstetrics and gynecology global health experiences for the medical student. Options for integration of obstetrics and gynecology global health into undergraduate medical curricula are discussed. Specific considerations for global health clinical experiences for medical students, including choosing a clinical location, oversight and mentorship, goals and objectives, predeparture preparation, and evaluation, are reviewed.

  18. Phytotherapeutic Agents for Benign Prostatic Hyperplasia: An Overview. (United States)

    Passi, Neelima Dhingra


    Benign prostatic hyperplasia (BPH) the most common condition in aging men is the non malignant enlargement of the prostate gland with increase in numbers of both epithelial and stromal cells within the periurethal transition zone of the prostate. Sources of symptoms in patient with BPH appear to be both static and dynamic component. Management of BPH has undergone a rapid evolution over the past decade to aid men with lower urinary tract symptoms attributed to bladder outlet obstruction. Treatment of clinical BPH aims to improve symptoms, prevent urinary tract infections, avoid renal insult, relief obstruction and improve bladder emptying.Prostate cancer patients and those with benign prostatic hyperplasia are increasingly exploring the use of plant derived non-nutritive compounds with protective or disease preventive properties, especially due to long term side effects of pharmacological treatment and risk of mortality associated with surgical procedures. Phytotherapeutic preparations are plant extracts with different components obtained by different extraction procedures. Numerous mechanisms of action have been postulated for mono and combination plant extracts. This article give a brief account of rationale and efficacy of various existing phytotherapeutic agents in the management of benign prostatic hyperplasia, including the herbs which hold the potential promise are also mentioned , although much research is still required.

  19. Gastropericardial fistula complicating benign gastric ulcer: case report

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    Simice, P.; Zwirewich, C.V. [Univ. of British Columbia, Vancouver General Hospital, Dept. of Radiology, Vancouver, BC (Canada)


    Pneumopericardium is a rare radiologic finding and is most commonly associated with esophageal ulceration or trauma. Benign ulcers of the distal esophagus are the most frequent source of non-traumatic perforation into the pericardial sac. Other etiologies include fistula formation from diseased subdiaphragmatic hollow viscera or subphrenic abscess, recent cardiac surgery, an extension of pneumomediastinum into the pericardium sac, and primary septic pericarditis from gasforming organisms. Pneumopericardium caused by the penetration of a benign gastric ulcer is a recognized but rare phenomenon. Intrathoracic gastric perforations are more commonly associated with pneumomediastium. Risk factors associated with an increased risk of penetration of gastric ulcers into the pericardium include the presence of a giant ulcer in the gastric fundus, an ulcer within a hiatus hernia, a history of hiatus hernia repair, concurrent use of non-steroidal anti-inflammatory drugs and the Zollinger-Ellison syndrome. Scar tissue formation at the site of previous hiatal surgery may result in the adherence of the gastric fundus or lower esophagus to the pericardium and produce a pathway for benign ulcers to erode into the pericardium.

  20. What's the appeal? Testing public service advertisements to raise awareness about gynecologic cancer. (United States)

    Cooper, Crystale Purvis; Gelb, Cynthia A; Chu, Jennifer


    In 2013, the Centers for Disease Control and Prevention's (CDC) Inside Knowledge: Get the Facts About Gynecologic Cancer campaign tested creative concepts for English- and Spanish-language video advertisements (for use on television and the Internet) with women aged 35-64 years. Sixteen English and nine Spanish focus groups were conducted in four U.S. cities. CDC used animatics (a series of photographs edited together with a sound track) to simulate produced advertisements, without having to incur the high cost of filming and production. Advertisement concepts consistently resonating with participants featured cancer survivors, were straightforward, included information about cancer symptoms, displayed Inside Knowledge educational materials, and featured diverse women. In the general population focus groups, a primacy testing order effect was observed in which the concept tested first tended to be the most favorably received. Varying the order in which concepts were tested and considering testing order when interpreting results was critical.

  1. [Laparoscopic diagnosis and treatment of early adhesive small bowel obstruction after gynecological surgery]. (United States)

    Timofeev, M E; Breusenko, V G; Shapoval'iants, S G; Fedorov, E D; Larichev, S E; Kretsu, V N


    It is presented the results of diagnostic and curative laparoscopic interventions in 33 patients with acute early adhesive small bowel obstruction. Ileus developed after surgical treatment (laparotomy) of different gynecological diseases. Laparoscopy appeared as the most informative diagnostic method to confirm diagnosis in all patients, to estimate state of abdominal cavity and small pelvis organs what can help to determine method of surgical treatment. Contraindications for laparoscopic surgery were identified in 12 (36.4%) patients and conversion to laparotomy was applied in this group. Postoperative complications were diagnosed in 1 (8.3%) patient. 2 (16.6%) patients died. Early adhesive ileus was resolved laparoscopically in 21 (63.6%) of 33 patients. Recurrent acute early adhesive ileus was detected in 1 (4.7%) patient.

  2. Trichomonas vaginalis vaginitis in obstetrics and gynecology practice: new concepts and controversies. (United States)

    Coleman, Jenell S; Gaydos, Charlotte A; Witter, Frank


    Trichomonas vaginalis (TV) is the most common curable sexually transmitted infection worldwide. Annually, 7.4 million new infections are estimated in the United States, which is greater than combined new cases of Chlamydia, gonorrhea, and syphilis. Serious adverse reproductive health outcomes including pregnancy complications, pelvic inflammatory disease, and an increased risk of HIV acquisition have been linked to TV infection. There are several sensitive and specific diagnostic tests available, including a newly approved nucleic acid amplification test (NAAT) that utilizes the same instrumentation platform and clinical sample as Chlamydia and gonorrhea tests. In this article, we review TV pathogenicity, adverse reproductive health outcomes, detection, and treatment followed by clinical scenarios for which TV diagnosis may prove useful in obstetrics and gynecology practice.

  3. Benign multicystic mesothelioma: a case report of three sisters

    Directory of Open Access Journals (Sweden)

    Thomas Rutherford


    Full Text Available Benign multicystic mesothelioma (BMCM is a rare tumor of the abdomen-peritoneum of unknown etiology. This benign tumor was initially described by Plaut in 1928 when he observed loose cysts in the pelvis during a surgery for a uterine leiomyoma.2 The mesothelial origin was later confirmed by electron micro-scopy by Mennemeyer and Smith in 1979.3 To date, there are approximately 140 cases of BMCM reported in the literature.4 This disease primarily occurs in pre-menopausal women and is associated with a history of pelvic inflammatory disease, prior abdominal surgery, and endometriosis.4,5 The pathogenesis of this disease remains controversial, with possible etiologies including a neoplastic versus a reactive process.5 In the literature, a few case reports discuss a possible genetic or familial association with BMCM.6 Specifically, one report describes a man with familial Mediterranean fever who developed BMCM. Although familial Mediter-ranean fever is associated with malignant mesothelioma, he had only BMCM, and did not suffer from malignant mesothelioma.6 A genetic evaluation and chromosomal analysis were not able to identify a specific genetic cause of the family’s pattern of disease. This case report describes two female siblings diagnosed with BMCM. In addition, a third sister also had findings consistent with BMCM, however, the discrete histological diagnosis was never confirmed.

  4. 超声手术刀在妇科腹腔镜手术中的应用价值%Application of ultrasonic scalpel in gynecologic operative laparoscopy

    Institute of Scientific and Technical Information of China (English)

    林俊; 张信美; 徐开红


    Objective To investigate the applied value of the ultrasonic scalpel in gynecologic operative laparoscopy. Methods Gynecologic operations were performed using the ultrasonic scalpel under laparoscopy. Operative bleeding and time, perioperative body temperature and hemogram, and tissue damage were observed.Results Forty-two cases of benign gynecologic diseases were treated with the ultrasonic scalpel under laparoscopy. Among them, there were 4 hysterectomies, 9 ovarian cystectomies, 18 salpingotomies, 4 ectopic pregnancies, 3 myomectomies, 3 adhesiolysis and 1 adnexectomy. The amount of operative bleeding, operating time and the tissue injury were related to the type of operation. The minimual operative bleeding amount, operating time, depth of tissue necrosis, tissue injury score and fibrin deposition score were 24.77±4.71ml, 23.39±3.01 min, 0.22±0.10mm, 0.98±0.21 and 0.38±0.26, respectively. The maximal operative bleeding amount, operating time, depth of tissue necrosis, tissue injury score and fibrin deposition score were 166.7±47.18ml, 127.2±16.99 min, 0.35±0.20mm, 1.25±0.20 and 0.81±0.29, respectively. The levels of body temperature, white blood cells and hemoglobin before and after the operations were not statistically different (P>0.05) except for hysterectomy (P<0.05). Conclusion The ultrasonic scalpel can be safely applied for gynecologic operative laparoscopy and should be used widely.%目的探讨超声手术刀在妇科腹腔镜手术中的应用价值。方法在腹腔镜下应用超声手术刀进行各种妇科手术,观察术中失血量、手术时间、围手术期体温和血象变化以及组织的损伤程度。结果在腹腔镜下使用超声手术刀进行各种手术42例。其中子宫切除术4例,卵巢囊肿剥出或切除术9例,输卵管切除术18例,输卵管切开取胚术4例,子宫肌瘤挖出术3例,单纯粘连分离术3例,附件切除术1例。术中失血量、手术时间以及对组织的损伤程

  5. Analysis of obstetric and gynecological surgeries among adolescent girls: lessons for prevention

    Directory of Open Access Journals (Sweden)

    Ruchi Kalra


    Full Text Available Background: Health of adolescent girls is a priority. Any operative surgery affects her physical and psychological health adversely. Aim: The study was done to analyze the operative burden on adolescent girls and identify the health needs of adolescent girls at our institute. Methods: A cross sectional study was done from May 2010 till Aug 2013. All adolescent girls (19 years age and below operated during this period at department of obstetrics and gynaecology, People's college of medical science and RC, Bhopal were included. Results: The operations were done on 54 adolescent girls during this period which was 1.37% of the total surgeries. Age wise distribution was as 50% were of 19 years age, 37% were 18 years, 7.4% were of 17 years and 5.5% were 16 years and below. 41% of them were admitted with labour complaints, 26% cases as abortions, 13% cases with pain in abdomen. 11% of cases had cyclical pain with primary amenorrhoea 5% were admitted with Primary amenorrhoea, 4% had complaints of perineum pain. Maximum surgeries for obstetrical indications were caesarean sections (41% cases followed by suction evacuation for abortion(26%. Among gynecological surgeries, maximum were done for imperforate hymen and partial vaginal septum (11% casesexploratory laparotomy for benign ovarian masses (9.25% cases. Diagnostic laparoscopy for primary amenorrhea was done (5.5% cases and operative laparoscopy (3.7% cases. 1.85% cases each were of pelvic abscess and bartholin cyst where I and D and marsupialization were done respectively. Conclusions: Obstetric operative burden on adolescent girls was very high. 67% of obstetric related surgeries can be prevented by educating and encouraging them to delay the onset of sexual activity and also by providing health related and contraceptive advices in schools and community settings. [Int J Reprod Contracept Obstet Gynecol 2015; 4(2.000: 355-359

  6. [Acute benign ataxia in childhood]. (United States)

    Grippo, J; Arroyo, H A; Rocco, R D; Iraola, J


    The patogenesis and etiology of acute ataxia in childhood is not well known. It may occur without previous symptoms or may be the expression of specific infectious diseases. Forty patients hospitalized at the Hospital de Niños de Buenos Aires en 1972-1978, were studied. The neurological manifestations showed an acute onset, being ataxia the main sign, associate to tremor, nystagmus, dysartria, oculo-motor paresia, muscular weakness, and hyporeflexia. Most of the patients (82%) became cured within the first four weeks. It is advisable to establish a follow-up with periodic controls, mainly in those patients in whom an association with previous infectious diseases did not exist to be able to detect an association with degenerative or desmyelinizing diseases.

  7. 前列腺特异性膜抗原定量检测在前列腺良恶性疾病诊断中的应用%Detection of prostate specific membrane antigen for the diagnosis of malignant and benign prostate diseases

    Institute of Scientific and Technical Information of China (English)

    瞿虎; 汪中扬; 邹自灏; 毛晓鹏


    Objective: To determine the diagnostic yield of prostate specific membrane antigen ( PSMA) for the diagnosis of benign or malignant prostate diseases. Methods: The relative expression of serum PSMA was assayed in patients with prostate carcinoma ( group PCa, n = 63) , benign prostate hypertrophy ( group BPH, n = 99) and healthy controls (control group, n = 33) by using real-time quantitative polymerase chain reaction for further determination of the between-group difference. Results: The between-group difference in PSMA reached statistical significance ( all P 0. 05). Conclusion; The PSMA in peripheral blood as determined by real-time quantitative PCR may help differentiate prostate carcinoma and benign prostate hypertrophy but could serve as an adjuvant or complementary approach owing to the limited significance for differentiation between patients with prostate diseases and normal controls.%目的:探讨前列腺特异性膜抗原(PSMA)对于前列腺良恶性疾病的诊断价值.方法:采用实时荧光定量PCR方法检测前列腺癌患者(前列腺癌组,63例)、良性前列腺增生患者(良性前列腺增生组,99例)及健康者(正常对照组,33例)血液中PSMA的相对表达量,并分析3组之间的差异.结果:3组间PSMA相对表达量存在差异(P<0.05),良性前列腺增生组、前列腺癌组均低于正常组(P<0.05),前列腺癌组高于良性前列腺增生组(P<0.05),良性前列腺增生组、前列腺癌组PSMA相对表达量与血清总前列腺特异性抗原TPSA不具相关性(P>0.05).结论:实时荧光定量PCR检测外周血PSMA可用于区分前列腺癌与良性前列腺增生,但单纯检测外周血PSMA尚无法准确区分出前列腺疾病与健康对照人群,仅可作为一种辅助和补充检测手段.

  8. Benign Joint Hypermobility Syndrome – not so ‘Benign’

    Directory of Open Access Journals (Sweden)

    Yathish GC


    Full Text Available Benign joint hypermobility syndrome (BJHS was earlier considered as a mild or trivial entity, but nowadays it is reported as a multisystem hereditary connective tissue disorder with serious morbidities. In fact, the term ‘Benign’ has been removed, renaming the disease as ‘Joint Hypermobility Syndrome’ (JHS. In addition to the well-known musculoskeletal consequences of joint pain and instability, it can cause chronic widespread pain, gastrointestinal dysmotility, anxiety, phobic states and dysautonomia. We present here the case of a 53-year-old lady who presented with history of irritable bowel syndrome, elbow dislocation, repeated knee injuries, and instability resulting in severe secondary osteoarthritis (OA.

  9. 不同年龄段女性妇科炎症分析%Analysis of gynecological inflammation infection of women in different ages

    Institute of Scientific and Technical Information of China (English)



    目的 分析不同年龄阶段女性的妇科卫生状况,探讨妇科炎症的发生规律.方法 选取2009年7月-2011年6月期间来我院妇科就诊及住院病例共1 400例,对其临床检验结果作出统计学分析.结果 妇科炎症中以附件炎发生率最高;不同年龄段的妇科炎症发病率差异具有统计学意义(P<0.05),16 ~25岁年龄组感染率最高,这可能与其处于性活跃期但经验缺乏有一定关系;在感染途径上,内源性感染较医源性感染和性传播感染发生率为高,差异具有统计学意义(P<0.05).结论 不同年龄段女性妇科炎症发病率存在差异,应加强对年轻女性性知识和日常性卫生的健康教育,以减少妇科炎症的发生.%Objective To analyze the gynecological health of women in different ages and investigate the infection regularity of gynecological inflammation. Methods Form July 2009 to June 2011, the clinical test statistical resulta of a total of 1 400 cases of hospitalized patients with gynecological inflammation infection in our hospital were analyzed. Results The disease with highest incidence of gynecological inflammation infection is accessories inflammation,the gynecological inflammation infection in different ages were statistically significant different (P<0.05) ,16-25 years age group has the highest rate of infection, which may be related to sexually active but lack of experience. For the routes of infection, the incidence of iatrogenic infection is higher than endogenous infection and sexually transmitted infection, the difference has statistical significance (P < 0. 05). Conclusion The gynecological inflammation incidence of women in different ages is different, young women should be strengthened routine health knowledge and sexual health education to reduce the incidence of gynecological inflammation infection.

  10. 超声检查对妇科急腹症的诊断价值%The Diagnostic Value of Ultrasonography in Gynecologic Acute Abdomen

    Institute of Scientific and Technical Information of China (English)

    孝文娜; 姜艳娜


    Objective: The value of ultrasonography in the diagnosis of gynecologic acute abdomen were discussed. Methods: 80 cases in our hospital gynecological acute abdomen patients as objects, implementing ultrasound for all patients for ultrasound imaging characteristics and to analyze the value of gynecologic acute abdomen. Results: 80 cases of gynecological acute abdomen types include acute pelvic inflammatory disease, ectopic pregnancy, ruptured corpus luteum and ovarian cyst torsion, ultrasonography were detected 73 patients, the diagnostic accuracy was 91.3%. Conclusion: Ultrasonography of the abdomen in patients with gynecological examination, diagnosis accuracy, safe and noninvasive, help clinicians diagnose and provide more evidence for the treatment, it is worth popularization and application.%目的:对超声检查对妇科急腹症的诊断价值进行探讨。方法选取我院收治的80例妇科急腹症患者为对象,对所有患者实施超声检查,对妇科急腹症的影像学特点以及超声检查价值进行分析。结果80例妇科急腹症的疾病类型主要包括急性盆腔炎、异位妊娠、黄体破裂以及卵巢囊肿蒂扭转,超声检查共检出73例患者,诊断准确率为91.3%。结论采用超声检查对妇科急腹症患者进行检查,诊断准确率高,安全无创,有利于临床医师的诊断,为治疗提供更多依据,值得普及和应用。

  11. Robotic radical hysterectomy in the management of gynecologic malignancies. (United States)

    Pareja, Rene; Ramirez, Pedro T


    Robotic surgery is being used with increasing frequency in gynecologic oncology. To date, 44 cases were reported in the literature of radical hysterectomy performed with robotic surgery. When comparing robotic surgery with laparoscopy or laparotomy in performing a radical hysterectomy, the literature shows that robotic surgery offers an advantage over the other 2 surgical approaches with regard to operative time, blood loss, and length of hospitalization. Future studies are needed to further elucidate the equivalence or superiority of robotic surgery to laparoscopy or laparotomy in performing a radical hysterectomy.

  12. Payment Reform: Unprecedented and Evolving Impact on Gynecologic Oncology

    Directory of Open Access Journals (Sweden)

    Sachin eApte


    Full Text Available With the signing of the Medicare Access and CHIP Reauthorization Act (MACRA in April 2015, the Centers for Medicare and Medicaid Services (CMS is now positioned to drive the development and implementation of sweeping changes to how physicians and hospitals are paid for the provision of oncology related services. These changes will have a long-lasting impact on the sub-specialty of gynecologic oncology, regardless of practice structure, physician employment and compensation model, or local insurance market. Recently, commercial payers have piloted various models of payment reform via oncology specific clinical pathways, oncology medical homes, episode payment arrangements, and accountable care organizations. Despite the positive results of some pilot programs, adoption remains limited. The goals are to eliminate unnecessary variation in cancer treatment, provide coordinated patient-centered care, while controlling costs. Yet, meaningful payment reform in oncology remains elusive. As the largest payer for oncology services in the United States, CMS has the leverage to make cancer services more value-based. Thus far, the focus has been around pricing of physician-administered drugs with recent work in the area of the Oncology Medical Home. Gynecologic oncology is a unique sub-specialty which blends surgical and medical oncology, with treatment that often involves radiation therapy. This forward-thinking, multi-disciplinary model works to keep the patient at the center of the care continuum and emphasizes care coordination. Because of the breadth and depth of gynecologic oncology, this sub-specialty has both the potential to be disrupted by payment reform as well as potentially benefit from the aspects of reform which can align incentives appropriately to improve coordination. Although the precise future payment models are unknown at this time, focused engagement of gynecologic oncologists and the full care team is imperative to assure that the

  13. Payment Reform: Unprecedented and Evolving Impact on Gynecologic Oncology (United States)

    Apte, Sachin M.; Patel, Kavita


    With the signing of the Medicare Access and CHIP Reauthorization Act in April 2015, the Centers for Medicare and Medicaid Services (CMS) is now positioned to drive the development and implementation of sweeping changes to how physicians and hospitals are paid for the provision of oncology-related services. These changes will have a long-lasting impact on the sub-specialty of gynecologic oncology, regardless of practice structure, physician employment and compensation model, or local insurance market. Recently, commercial payers have piloted various models of payment reform via oncology-specific clinical pathways, oncology medical homes, episode payment arrangements, and accountable care organizations. Despite the positive results of some pilot programs, adoption remains limited. The goals are to eliminate unnecessary variation in cancer treatment, provide coordinated patient-centered care, while controlling costs. Yet, meaningful payment reform in oncology remains elusive. As the largest payer for oncology services in the United States, CMS has the leverage to make cancer services more value based. Thus far, the focus has been around pricing of physician-administered drugs with recent work in the area of the Oncology Medical Home. Gynecologic oncology is a unique sub-specialty that blends surgical and medical oncology, with treatment that often involves radiation therapy. This forward-thinking, multidisciplinary model works to keep the patient at the center of the care continuum and emphasizes care coordination. Because of the breadth and depth of gynecologic oncology, this sub-specialty has both the potential to be disrupted by payment reform as well as potentially benefit from the aspects of reform that can align incentives appropriately to improve coordination. Although the precise future payment models are unknown at this time, focused engagement of gynecologic oncologists and the full care team is imperative to assure that the practice remains patient centered


    Directory of Open Access Journals (Sweden)

    F. Ghaemmaghami T. Ashraf Ganjoie


    Full Text Available Early recognition of Gestational Trophoblastic Neoplasm (GTN will maximize the chances of cure with chemotherapy but some patients present with many different symptoms months or even years after the causative pregnancy making diagnosis difficult. Clinicians should be aware of the possibility of GTN in any reproductive age woman with bizarre central nervous system, gastrointestinal, pulmonary symptoms or radiographic evidence of metastatic tumor of unknown primary origin. We reported five cases of metastatic gestational trophoblastic neoplasms with bizarre pulmonary symptoms, acute abdomen, neurologic symptoms presenting without gynecological symptoms.

  15. Benign multicystic peritoneal mesothelioma: a case report

    Directory of Open Access Journals (Sweden)

    Papapaulou Leonidas


    Full Text Available Abstract Introduction We report the case of a patient with a benign multicystic peritoneal mesothelioma and describe its appearance on computed tomography scans and ultrasonography, in correlation with gross clinical and pathological findings. Case presentation A 72-year-old Caucasian woman presented to our emergency department with acute abdomen signs and symptoms. A clinical examination revealed a painful palpable mass in her left abdomen. Abdominal ultrasonography and computed tomography demonstrated the presence of a large cystic mass in her left upper abdomen, adjacent to her left hemidiaphragm. The lower border of the mass extended to the upper margin of her pelvis. A complete resection of the lesion was performed. Pathological analysis showed a benign multicystic peritoneal mesothelioma. Conclusions Benign multicystic peritoneal mesothelioma is a rare lesion with a non-specific appearance on imaging. Its diagnosis always requires pathological analysis.

  16. [Method and evaluation of hormone assays in practical obstetrics and gynecology]. (United States)

    Tanizawa, O


    Hormone assays are very important in obstetrics and gynecology. Today, I want to talk about how to measure hormones and how to evaluate the data obtained for therapeutic purposes. In humans, there are two mechanisms of control, neural control and endocrine control. Generally speaking, the neural system controls organs directly via various neurotransmitters, while the endocrine system controls organs by hormones transported in the blood. In fact, recent progress in hormone research has shown that this concept should be modified, because some hormones act as neurotransmitters or regulate other cells or even endocrine cells themselves in the same organ. But I shall not go into this. Today's lecture is focused on hormones that are closely related to clinical obstetrics and gynecology. The hormones that are important are those in females, reproduction, and pregnancy, and tumors. First, and most important, is that patients acquire femininity in the physiological and psychological sense by hormones. The hormones closely related to this are estrogens and pituitary hormones. For reproduction, cyclic hormonal change is important. In the reproductive period, women have menstruation and ovulation along with cyclic changes of ovarian and pituitary hormones. After conception, various kinds of hormones, including hCG, HPL and estriol, are secreted from the feto-placental system. These hormones are used clinically as a markers of placental function. Hormones also have important roles in oncology. hCG is an excellent marker of trophoblastic diseases. Endometrial cancer is expected respond to large doses of progestins if they have progesterone receptors. There are three types of hormone assays, biological assays, immunological assays and chemical assays.(ABSTRACT TRUNCATED AT 250 WORDS)


    Directory of Open Access Journals (Sweden)



    Full Text Available INTRODUCTION: Open biopsy is widely considered to be the procedure of choice for diagnostic tissue sampling of bone tumors. However, associated disadvantages include in - patient procedure requiring hospitalization, risk of infection, hematoma formation and pathological fractures. As an alternative FNA cytology is increasingly used as a diagnostic modality. It is a challenging technique due to difficulties in approaching bone lesions and obtaining adequate material. AIMS: 1. To study the prevalence and distribution of various breast lesions in women of various age groups. 2. To classify the smears into C1 - C5 category . 3. To enumerate the difficulties encountered in this study. 4. To emphasize the role of FNAC in diagnostic workup in breast lesions. MATERIALS AND METHODS: FNAC was done on 208 cases of breast lesions from September 2011 to July 2012 in department of Pathology, Bowring hospital, BMC&RI, Bangalore. Cases presenting to the OPD with b r east lumps were subjected for FNAC. Aspirations were carried out with 10ml disposable syringe with a 22guage needle, materi al was obtained. Aspirates were smeared and few of them were immediately fixed with methanol and stained with H&E, rest of the smears were air dried for MGG staining. The diagnostic criteria C1 - C5 as recommended by NHS breast screening program has been inc orporated for reporting the slides along with pathological diagnosis wherever possible. RESULTS : 1. In countries with limited resources like India, FNAC may be used as the first line of diagnostic tool for evaluating breast lesions. 2. Breast FNA continues its monopoly over core biopsy and open excision biopsy. Benign conditions of breast can be diagnosed easily on FNA if done accurately. The current usage of C1 - C5 categories in typing the breast lesions gives a wide scope for pathologist to place the doubt ful lesions freely in the categories. However a disease specific diagnosis was preferred by the clinicians. 3. In

  18. Benign fasciculations and Corticosteroid use: possible association? An update

    Directory of Open Access Journals (Sweden)

    Marco Orsini


    Full Text Available Fasciculations are characterized by visible subtle and fast contractions of muscle, even wormlike in movement, by the contraction of a fascicle of muscle fibers. The authors present the case study of a 28-year-old patient with the appearance of migratory and diffuse fasciculations with an onset after partial tapering off of oral corticosteroides (60 mg total dose indicated for treatment of Minimal change Glomerulopathy. Clinical Neurological physical exam allied with an ENMG, besides other complementary laboratory exams were used for screening the above-mentioned patient. Afterwards, current research relating to the topic at hand was made in order to update the data available in the Bireme, Scielo and PubMed Data Banks using the following key words: Fasciculation’s, motor neuron disease, and benign fasciculations in the Portuguese, English as well as Spanish language. Although fasciculation’s are most commonly associated with Motor neuron disease as well as with certain metabolic disorders, they may also be present in individuals with absolutely no underlying pathological disorders. In our case, fasciculation potentials that have been present for six months, with no other signs of a neurogenic disorder as well as absence of laboratory findings, the patient received a diagnosis of Benign Fasciculation Syndrome (BFS.We believe that the use of corticosteroides in high doses with subsequent tapering contributed to the fasciculation’s, especially due to the changes that this causes on the ionic channels. Fasciculation’s are symptoms seen in a large range of conditions, and also being the main symptom of the so-called Benign Fasciculation Syndrome. We have presented an example of this clinical syndrome in a patient whose complaint was fasciculation’s, with complete clinical remission of symptoms following complete tapering off of corticosteroid six months previously.

  19. The work place educational: climate in gynecological oncology fellowships across Europe: the impact of accreditation

    NARCIS (Netherlands)

    Piek, J.M.J.; Bossart, M.; Boor, K.; Halaska, M.J.; Haidopoulos, D.; Zapardiel, I.; Grabowski, J.P.; Kesic, V.; Cibula, D.; Colombo, N.; Verheijen, RHM; Manchanda, R.


    Background: A good educational climate/environment in the workplace is essential for developing high-quality medical (sub)specialists. These data are lacking for gynecological oncology training. Objective: This study aims to evaluate the educational climate in gynecological oncology training through

  20. Gynecologic oncology training systems in europe: a report from the European network of young gynaecological oncologists

    DEFF Research Database (Denmark)

    Gultekin, Murat; Dursun, Polat; Vranes, Boris;


    The objectives of the study were to highlight some of the differences in training systems and opportunities for training in gynecologic oncology across Europe and to draw attention to steps that can be taken to improve training prospects and experiences of European trainees in gynecologic oncology....

  1. Suprapubic compared with transurethral bladder catheterization for gynecologic surgery: a systematic review and meta-analysis.

    LENUS (Irish Health Repository)

    Healy, Eibhlín F


    Suprapubic catheterization is commonly used for postoperative bladder drainage after gynecologic procedures. However, recent studies have suggested an increased rate of complications compared with urethral catheterization. We undertook a systematic review and meta-analysis of randomized controlled trials comparing suprapubic catheterization and urethral catheterization in gynecologic populations.

  2. Handling Sexuality Concerns in Women with Gynecological Cancer: Egyptian Nurse's Knowledge and Attitudes (United States)

    Mansour, Suzan E.; Mohamed, Hanan E.


    Sexuality is an important part of normal human functioning. Gynecological cancer diagnosis and treatment has devastating effect on Sexual issues. Study aim was to investigate Oncology Nurses knowledge and attitudes in Relation to Provision of Sexual Health Care to Women Diagnosed with Gynecological Cancer. The study setting was conducted at…

  3. Radiofrequency ablation for benign thyroid nodules. (United States)

    Bernardi, S; Stacul, F; Zecchin, M; Dobrinja, C; Zanconati, F; Fabris, B


    Benign thyroid nodules are an extremely common occurrence. Radiofrequency ablation (RFA) is gaining ground as an effective technique for their treatment, in case they become symptomatic. Here we review what are the current indications to RFA, its outcomes in terms of efficacy, tolerability, and cost, and also how it compares to the other conventional and experimental treatment modalities for benign thyroid nodules. Moreover, we will also address the issue of treating with this technique patients with cardiac pacemakers (PM) or implantable cardioverter-defibrillators (ICD), as it is a rather frequent occurrence that has never been addressed in detail in the literature.

  4. 乳腺内钙化在乳腺良恶性病变中的X线诊断价值%Evaluation of the benign and malignant mammary disease judged by calcification in the mammary gland by the X-ray diagnosis

    Institute of Scientific and Technical Information of China (English)

    李秀红; 王彩云


    Objective:To study the evaluation of the benign and malignant mammary disease judged by calcification in the mammary gland by the X-ray diagnosis. Methods:Review and analysis were done of the 106 cases of the calcification judged by the breast X-ray imaging certified by pathology,the cases were classified by the BI-RADS. The classified results were compared twith the pathology results after surgery. Results:There were 71 cases of benign calcification,23 cases of malignant calcification and 12 cases of central type calcification manifested by the X-ray. Among them,there were 69 be-nign cases,20 malignant cases and 5 malignant cases correspondently in pathology. Conclusion:The morphology and the distribution of the calcification in the mammary gland is helpful for the differentiated diagnosis.%目的:探讨乳腺内钙化在乳腺良恶性病变中的X线诊断价值。方法回顾性分析经病理证实的乳腺X线摄影确认的106例钙化病例,采用乳腺影像报告和数据系统( BI-RADS)分级,并与手术病理结果对照分析。结果 X线征象为良性钙化的71例中,病理结果良性69例;X线征象为恶性钙化的23例中,病理结果恶性20例;X线征象为中间型钙化的12例中,病理结果恶性5例。结论乳腺内钙化的形态及分布有助于乳腺良恶性病变的鉴别诊断。

  5. Hope pictured in drawings by women newly diagnosed with gynecological cancer

    DEFF Research Database (Denmark)

    Hammer, Kristianna; Hall, Elisabeth; Mogensen, Ole


    BACKGROUND:: In mysterious ways, hope makes life meaningful even in chaotic and uncontrolled situations. When a woman is newly diagnosed with gynecologic cancer, hope is ineffable and needs exploring. Drawings help express ineffable phenomena. OBJECTIVE:: The aim of the study was to explore how...... women newly diagnosed with gynecologic cancer express the meaning of hope in drawings. METHOD:: Participants were 15 women who on the same day had received the diagnosis of gynecologic cancer. They were between 24 and 87 years (median, 52 years) with a variety of gynecologic cancer diagnoses. Data from...... through metaphors and incorporates internal, external, and relational aspects. With other words, inner willpower, experiences in open nature, and closeness to loved ones contribute to hope when newly diagnosed with gynecologic cancer. IMPLICATION FOR PRACTICE:: The use of drawings in clinical situations...

  6. Patient Perceptions of Open, Laparoscopic, and Robotic Gynecological Surgeries

    Directory of Open Access Journals (Sweden)

    Mohamad Irani


    Full Text Available Objective. To investigate patient knowledge and attitudes toward surgical approaches in gynecology. Design. An anonymous Institutional Review Board (IRB approved questionnaire survey. Patients/Setting. A total of 219 women seeking obstetrical and gynecological care in two offices affiliated with an academic medical center. Results. Thirty-four percent of the participants did not understand the difference between open and laparoscopic surgeries. 56% of the participants knew that laparoscopy is a better surgical approach for patients than open abdominal surgeries, while 37% thought that laparoscopy requires the surgeon to have a higher technical skill. 46% of the participants do not understand the difference between laparoscopic and robotic procedures. 67.5% of the participants did not know that the surgeon moves the robot’s arms to perform the surgery. Higher educational level and/or history of previous abdominal surgeries were associated with the highest rates of answering all the questions correctly (p<0.05, after controlling for age and race. Conclusions. A substantial percentage of patients do not understand the difference between various surgical approaches. Health care providers should not assume that their patients have an adequate understanding of their surgical options and accordingly should educate them about those options so they can make truly informed decisions.

  7. Changes in the Practice of Obstetrics and Gynecology. (United States)

    Rayburn, William F; Tracy, Erin E


    A projected shortage of obstetrician-gynecologists (OB-GYNs) is a result of both the increasing US population and the relatively static number of residency graduates. In addition, generational changes have contributed to increasing subspecialization, more desiring part-time employment, and earlier retirement. This article reviews data regarding changes in the practice of obstetrics and gynecology. Residency education is focusing more on a core curriculum in general obstetrics and gynecology, while subspecialty fellowship training has grown in popularity. There are no recent data to describe whether OB-GYNs are working fewer hours, yet more are employed in larger practices at mostly metropolitan locations. A team-based care model that incorporates nonphysician clinicians and digital conversion of clinical data has been encouraged to increase accessibility, improve comprehensiveness, commit to more continuity of care, and reduce redundancy. Compared with other medical specialists, OB-GYNs retire slightly earlier, especially females who will represent the field more. The specialty is moving toward a more comprehensive women's health care practice model that is more patient-centered, efficient, cost controlling, team-based, and adaptable to the needs of a diverse population. Implications from these changes for our practices and improving patient care are currently unclear and await more reported experience.


    Directory of Open Access Journals (Sweden)



    Full Text Available The ultimate controlling process of education is evaluation which not only monitors the progress and achievements of students but also provides important feedback towards modification and improvement of teaching learning process. Present study was conducted to evaluate the undergraduate curriculum in Obstetrics and Gynecology. Ninety one students of final MBBS students participated in the study. Student feedback was taken by preparing a questionnaire. The opinions were recorded and analyzed. In the present stud y 94.50% felt that the classes in the final year should be taken regularly by the senior faculty. In the clinical postings 14.28% had seen MTP and method of taking Pap smear was seen by 19.78% of student’s .At the end of the clinical posting the students w ere confident about conducting normal delivery and suturing episiotomy. They were not confident in seeing cross matching (9.89% and management of PPH (28.57%. The areas to be strengthened in the present curriculum are: More practical sessions in taking p ap smears, seeing cross matching and management of emergencies in Obstetrics and Gynecology.

  9. Cross-Cultural Obstetric and Gynecologic Care of Muslim Patients. (United States)

    Shahawy, Sarrah; Deshpande, Neha A; Nour, Nawal M


    With the growing number of Muslim patients in the United States, there is a greater need for obstetrician-gynecologists (ob-gyns) to understand the health care needs and values of this population to optimize patient rapport, provide high-quality reproductive care, and minimize health care disparities. The few studies that have explored Muslim women's health needs in the United States show that among the barriers Muslim women face in accessing health care services is the failure of health care providers to understand and accommodate their beliefs and customs. This article outlines health care practices and cultural competency tools relevant to modern obstetric and gynecologic care of Muslim patients, incorporating emerging data. There is an exploration of the diversity of opinion, practice, and cultural traditions among Muslims, which can be challenging for the ob-gyn who seeks to provide culturally competent care while attempting to avoid relying on cultural or religious stereotypes. This commentary also focuses on issues that might arise in the obstetric and gynecologic care of Muslim women, including the patient-physician relationship, modesty and interactions with male health care providers, sexual health, contraception, abortion, infertility, and intrapartum and postpartum care. Understanding the health care needs and values of Muslims in the United States may give physicians the tools necessary to better deliver high-quality care to this minority population.

  10. Insufficiency fractures following radiation therapy for gynecologic malignancies

    Energy Technology Data Exchange (ETDEWEB)

    Ikushima, Hitoshi; Takegawa, Yoshihiro; Matsuki, Hirokazu; Yasuda, Hiroaki; Kawanaka, Takashi; Shiba, Atsushi; Kishida, Yoshiomi; Iwamoto, Seiji; Nishitani, Hiromu [Tokushima Univ. (Japan). School of Medicine


    The purpose of this study was to investigate the incidence, clinical and radiological findings of insufficiency fractures (IF) of the female pelvis following radiation therapy. We retrospectively reviewed the radiation oncology records of 108 patients with gynecologic malignancies who underwent external beam radiation therapy of the whole pelvis. All patients underwent conventional radiography and computed tomography (CT) scan every 6 months in follow-up after radiation therapy and magnetic resonance imaging (MRI) and radionuclide bone scan were added when the patients complained of pelvic pain. Thirteen of 108 patients (12%) developed IF in the irradiated field with a median interval of 6 months (range 3-51) from the completion of external beam radiation therapy. All patients who developed IF were postmenopausal women. Age of the patients who developed IF was significantly higher than that of the other patients. The parts of IF were sacroiliac joints, pubis, sacral body and 5th lumbar vertebra and six of 14 patients had multiple lesions. Treatment with rest and nonsteroidal anti-inflammatory drugs lead to symptomatic relief in all patients, although symptoms lasted from 3 to 20 months. Radiation-induced pelvic IF following radiation therapy for gynecologic malignancies were frequently observed in the post-menopausal patients within 1 year after external beam radiation therapy. Symmetrical fractures of the bilateral sacroiliac joint and pubis were the characteristic pattern of pelvic IF. All patients healed with conservative treatment, and nobody became non-ambulant. (author)

  11. Gynecologic care of the female-to-male transgender man. (United States)

    Dutton, Lauren; Koenig, Karel; Fennie, Kristopher


    Transgender men are a vulnerable population whose health care needs have been difficult to identify because of limited research and an inability to identify the population. Limited evidence suggests that transgender men are at increased risk of having polycystic ovarian syndrome, contracting HIV, experiencing violence, and committing suicide. This qualitative study, conducted through face-to-face interviews of a convenient sample, was a three-part interview containing a demographic and health questionnaire, the Norbeck Social Support Questionnaire, as well as the Health Care Relationship Trust Scale. Audio recordings and written notes were reviewed and common themes were identified via content analysis. Six self-identified transgender men between the ages of 19 and 45 years were enrolled in the study. Participants were at varying degrees of social and medical transition. Four major themes were identified: 1) receiving gynecologic care was perceived to be important; 2) breasts caused the most gender identity conflict; 3) transgender men struggle with revealing their gender identity to health care providers; and 4) the male/female boxes on health intake forms, as well as pronoun usage by medical staff, were barriers to receiving health care. This gynecologic health care needs assessment of transgender men begins to characterize the barriers transgender men face when seeking health care.

  12. Stability and Change of Interest in Obstetrics-Gynecology among Medical Students: Eighteen Years of Longitudinal Data. (United States)

    Forouzan, Iraj; Hojat, Mohammadreza


    A study investigated, first, the percentage of medical students maintaining interest in obstetrics/gynecology during medical school compared to those maintaining interest in other specialties and, second, changes of interest from obstetrics/gynecology to other specialties and other specialties to obstetrics/gynecology. Results indicate instability…

  13. MR features of physiologic and benign conditions of the ovary

    Energy Technology Data Exchange (ETDEWEB)

    Tamai, Ken; Saga, Tsuneo; Kido, Aki; Kataoka, Masako; Umeoka, Shigeaki; Togashi, Kaori [Kyoto University, Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto (Japan); Koyama, Takashi [Kyoto University Hospital, Department of Radiology, Kyoto (Japan); Fujii, Shingo [Kyoto University, Department of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto (Japan)


    In reproductive women, various physiologic conditions can cause morphologic changes of the ovary, resembling pathologic conditions. Benign ovarian diseases can also simulate malignancies. Magnetic resonance imaging (MRI) can play an important role in establishing accurate diagnosis. Functional cysts should not be confused with cystic neoplasms. Corpus luteum cysts typically have a thick wall and are occasionally hemorrhagic. Multicystic lesions that may mimic cystic neoplasms include hyperreactio luteinalis, ovarian hyperstimulation syndrome, and polycystic ovary syndrome. Recognition of clinical settings can help establish diagnosis. In endometrial cysts, MRI usually provides specific diagnosis; however, decidual change during pregnancy should not be confused with secondary neoplasm. Peritoneal inclusion cysts can be distinguished from cystic neoplasms by recognition of their characteristic configurations. Ovarian torsion and massive ovarian edema may mimic solid malignant tumors. Recognition of normal follicles and anatomic structures is useful in diagnosing these conditions. In pelvic inflammatory diseases, transfascial spread of the lesion should not be confused with invasive malignant tumors. Radiologic identification of abscess formation can be a diagnostic clue. Many benign tumors, including teratoma, Brenner tumor, and sex-cord stromal tumor, frequently show characteristic MRI features. Knowledge of MRI features of these conditions is essential in establishing accurate diagnosis and determining appropriate treatment. (orig.)

  14. 良性甲状腺疾病患者血清 IgE、FcεRIα及其抗体水平分析%Analysis on the expressions of serum IgE, FcεRI and their antibodies in patients with benign thyroid diseases

    Institute of Scientific and Technical Information of China (English)

    王玉萍; 崔泽林; 蔺丽慧; 王娟; 李佳; 彭霞; 谢国钢; 李莉


    Objective To analyze the expressions of immunoglobulin E (IgE), FcεRIαand their antibodies in serum from patients with benign thyroid diseases and investigate their relationships with benign thyroid diseases. Methods A total of 41 Graves′disease (GD) patients, 36 Hashimoto′s thyroiditis (HT) patients, 36 thyroid nodule (TN) patients and 60 healthy subjects were enrolled.The expressions of FcεRIα, anti-IgE antibody and anti-FcεRI antibody were determined by competitive enzyme-linked immunosorbent assay ( ELISA), and the level of IgE was determined by rate nephelometry.Their differences in 4 groups and their relationships with benign thyroid diseases were analyzed.Results The levels of IgE in GD, HT and TN groups had no statistical significance compared with that in healthy control group (P >0.05).The serum levels of FcεRIαand anti-IgE antibody in GD, HT and TN groups were higher than that in healthy control group (P <0.05).The level of anti-FcεRI antibody in GD group was higher than that in healthy control group.The relationships of the serum levels of IgE, FcεRIα, anti-IgE antibody and anti-FcεRI antibody with thyroid hormone autoantibody (TRAb) were not observed in HT or TN group, but there was a negative correlation of serum FcεRIαwith TRAb (rs =-0.350, P <0.05), and there was a positive positive correlation of anti-IgE and anti-FcεRI antibodies with TRAb in GD group (rs =0.546 and 0.520, P <0.05).Conclusions There are high expressions of serum IgE, FcεRIαand their antibodies in patients with benign thyroid diseases and a significant correlation of them with TRAb in GD group.The results suggest that these antibodies may participate in the occurrence and progress of benign thyroid diseases.%目的:分析免疫球蛋白(IgE)、FcεRIα及其抗体水平在良性甲状腺疾病患者血清中的表达情况,探讨其与良性甲状腺疾病的相关性。方法收集41例 Graves′病(GD)、36例桥本甲状腺炎(HT)和36例甲

  15. A Public Health Priority: Disparities in Gynecologic Cancer Research for African-Born Women in the United States (United States)

    Pinder, Leeya F.; Nelson, Brett D.; Eckardt, Melody; Goodman, Annekathryn


    African-born immigrants comprise one of the fastest growing populations in the U.S., nearly doubling its population size in recent years. However, it is also one of the most underrepresented groups in health-care research, especially research focused on gynecologic and breast malignancies. While the opportunity exists for access to an advanced health-care system, as immigrants migrate to the U.S., they encounter the same health-care inequalities that are faced by the native-born population based on ethnicity and social class, potentiated by limitations of health literacy and lack of familiarity with U.S. health systems. Given the continued influx of African-born immigrants in the U.S., we sought to understand the representation of this population in cervical and breast cancer research, recognizing the population’s high risk for these diseases at baseline while residing in their native countries. We determined that there is limited research in these diseases that disproportionately affect them; yet, there are identifiable and potentially modifiable factors that contribute to this paucity of evidence. This clinical commentary seeks to underscore the clear lack of research available involving African-born immigrants with respect to gynecologic and breast malignancies in the existing literature, demonstrate the need for more robust research in this population, and provide fundamental insights into barriers and solutions critical to the continued health of this growing population. PMID:27499654

  16. Urodynamic implications of benign prostatic hyperplasia

    DEFF Research Database (Denmark)

    Jensen, K M; Andersen, J T


    By the age of 60, about 70% of men have developed benign prostatic hyperplasia (BPH), and 85%-95% of these have symptomatic dysfunction of the lower urinary tract, 10%-20% undergoing prostatectomy. Although transurethral resection of the prostate is generally considered to be a safe and effective...

  17. Laparoscopic Management of Benign Ovarian Masses

    Directory of Open Access Journals (Sweden)

    Rachana Saha


    Full Text Available Introduction: Laparoscopic surgery is one of the most common procedures performed for benign ovarian masses. The aim of the study was to analyze all benign ovarian masses treated laparoscopically to assess safety, feasibility and outcome. Methods: A prospective study was carried out at Kathmandu Medical College Teaching Hospital, Sinamangal, Nepal. All the patients undergoing laparoscopic surgery for benign ovarian masses from 1st January 2012 to 31st December 2012 were included in the study. The pre-operative findings, intra-operative findings, operative techniques and post-operative complications were analyzed. Results: Thirty-six patients were taken for the study. Two cases were excluded since intra-operatively they were tubo-ovarian masses. The most common tumor was dermoid cyst (n=13; 38.23% and endometriotic cyst (n=14; 41.17%. Out of 34 cases, five cases of endometriotic cyst (14.70% were converted to laparotomy due to severe adhesions and four cases of endometriotic cyst underwent deroofing surgery. Two cases underwent laparoscopic assisted vaginal hysterectomy with bilateral salphingo-oopherectomy. Successful cystectomies were carried out in 22 cases. None were malignant. Major complications were not noted while minor complications like port-site infection (n=3; 8.82% and subcutaneous emphysema (n=1; 2.9% were present. Conclusions: Laproscopic management of benign ovarian masses is safe and feasible.

  18. Imaging features of benign adrenal cysts

    Energy Technology Data Exchange (ETDEWEB)

    Sanal, Hatice Tuba [Department of Radiology, Gulhane Military Medical Academy, Ankara (Turkey)]. E-mail:; Kocaoglu, Murat [Department of Radiology, Gulhane Military Medical Academy, Ankara (Turkey); Yildirim, Duzgun [Department of Radiology, Gulhane Military Medical Academy, Ankara (Turkey); Bulakbasi, Nail [Department of Radiology, Gulhane Military Medical Academy, Ankara (Turkey); Guvenc, Inanc [Department of Radiology, Gulhane Military Medical Academy, Ankara (Turkey); Tayfun, Cem [Department of Radiology, Gulhane Military Medical Academy, Ankara (Turkey); Ucoz, Taner [Department of Radiology, Gulhane Military Medical Academy, Ankara (Turkey)


    Benign adrenal gland cysts (BACs) are rare lesions with a variable histological spectrum and may mimic not only each other but also malignant ones. We aimed to review imaging features of BACs which can be helpful in distinguishing each entity and determining the subsequent appropriate management.

  19. Benign prostatic hyperplasia: symptoms and objective interpretation

    DEFF Research Database (Denmark)

    Andersen, J T


    Considerable new knowledge about benign prostatic hyperplasia has been gained over the past two decades, particularly with regard to its natural history, hydrodynamic changes in the lower urinary tract, and the symptomatic and urodynamic results of treatment. A survey of the literature has been u...

  20. 高尔基糖蛋白73在各种良性终末期肝病肝组织中的表达%Expression of Golgi protein-73 in the liver tissue of patients with benign end-stage liver diseases

    Institute of Scientific and Technical Information of China (English)

    单姗; 陈虹; 王乐天


    背景:高尔基糖蛋白73是随着蛋白质组学技术发展而新近发现的糖蛋白,与各种急慢性肝炎及肝癌关系密切.目的:观察高尔基糖蛋白73在各种终末期良性肝病行肝移植的病肝组织和正常肝脏组织中的表达及其意义,并分析与预后的关系.方法:采用免疫组织化学染色SP法检测113例因各种终末期良性肝病行肝移植的石蜡标本及10例供肝正常肝脏组织中高尔基糖蛋白73的表达.结果与结论:高尔基糖蛋白73在因各种终末期良性肝病行肝移植的病肝组织中均有表达且表达水平高于正常肝脏组织.高尔基糖蛋白73在自身免疫性肝炎所致肝硬化中的表达水平高于其在乙肝肝硬化中的表达水平,高尔基糖蛋白73在其他各组病肝组织中表达均无差异.提示高尔基糖蛋白73在自身免疫性肝炎依赖的非病毒途径中的表达可能高于其在HBV病毒途径中的表达.%BACKGROUND: Golgi protein-73 is a glycoprotein which discovered with the proteomics technology development. It has close relation with acute and chronic hepatitis and hepatocellular cancer. OBJECTIVE: To investigate the expression of Golgi protein-73 in liver tissue of the patients with benign end-stage liver diseases and normal liver tissue, and to analyze their clinical significance and prognostic value. METHODS: 113 specimens of liver transplantation for patients with benign end-stage liver disease and 10 normal liver specimens were included in the study. The expressions of Golgi protein-73 in these specimens were detected by immunohistochemistry. RESULTS AND CONCLUSION: Golgi protein-73 expression levels in specimens of liver transplantation for patients with benign end-stage liver diseases were higher than those in normal liver specimens without liver disease. Golgi protein-73 expression levels in specimens of autoimmune hepatitis cirrhosis were higher than those in hepatitis B cirrhosis. There was no significant difference

  1. Selective progesterone receptor modulators (SPRMs): progesterone receptor action, mode of action on the endometrium and treatment options in gynecological therapies (United States)

    Wagenfeld, Andrea; Saunders, Philippa T.K.; Whitaker, Lucy; Critchley, Hilary O.D.


    ABSTRACT Introduction: The progesterone receptor plays an essential role in uterine physiology and reproduction. Selective progesterone receptor modulators (SPRMs) have emerged as a valuable treatment option for hormone dependent conditions like uterine fibroids, which have a major impact on women’s quality of life. SPRMs offer potential for longer term medical treatment and thereby patients may avoid surgical intervention. Areas covered: The authors have reviewed the functional role of the progesterone receptor and its isoforms and their molecular mechanisms of action via genomic and non-genomic pathways. The current knowledge of the interaction of the PR and different SPRMs tested in clinical trials has been reviewed. The authors focused on pharmacological effects of selected SPRMs on the endometrium, their anti-proliferative action, and their suppression of bleeding. Potential underlying molecular mechanisms and the specific histological changes in the endometrium induced by SPRMs (PAEC; Progesterone receptor modulator Associated Endometrial Changes) have been discussed. The clinical potential of this compound class including its impact on quality of life has been covered. Expert Opinion: Clinical studies indicate SPRMs hold promise for treatment of benign gynecological complaints (fibroids, heavy menstrual bleeding; HMB). There however remains a knowledge gap concerning mechanism of action. PMID:27138351

  2. Fibrocystic breast disease (United States)

    Fibrocystic breast disease; Mammary dysplasia; Diffuse cystic mastopathy; Benign breast disease; Glandular breast changes ... made in the ovaries may make a woman's breasts feel swollen, lumpy, or painful before or during ...

  3. The effect of the SNAPPS (summarize, narrow, analyze, probe, plan, and select) method versus teacher-centered education on the clinical gynecology skills of midwifery students in Iran (United States)


    This study aimed to determine the effect of the SNAPPS (summarize, narrow, analyze, probe, plan, and select) method versus teacher-centered education on the clinical skills of midwifery students in Iran. In this clinical trial, 36 midwifery students in their 4th year of education in 2015 were enrolled and divided into 6 groups, 3 groups for teacher-centered education and 3 groups for the SNAPPS method, with each group spending 10 days in the outpatient gynecology clinic. A questionnaire and a checklist were used to gather data. An independent t-test and chi-square test were used to analyze the data. Ability to gain the trust of the patient, verbal and nonverbal communication skills, history taking, preparation of the patient for gynecological examination, and diagnosis and treatment of common diseases were significantly better in the SNAPPS group compared to the teacher-centered education group (P<0.05). The SNAPPS education method can significantly improve the clinical skills of midwifery students in gynecology, in particular history taking, differential diagnosis, and treatment of common diseases. PMID:27894183

  4. The effect of the SNAPPS (summarize, narrow, analyze, probe, plan, and select method versus teacher-centered education on the clinical gynecology skills of midwifery students in Iran

    Directory of Open Access Journals (Sweden)

    Hamideh Barangard


    Full Text Available This study aimed to determine the effect of the SNAPPS (summarize, narrow, analyze, probe, plan, and select method versus teacher-centered education on the clinical skills of midwifery students in Iran. In this clinical trial, 36 midwifery students in their 4th year of education in 2015 were enrolled and divided into 6 groups, 3 groups for teacher-centered education and 3 groups for the SNAPPS method, with each group spending 10 days in the outpatient gynecology clinic. A questionnaire and a checklist were used to gather data. An independent t-test and chi-square test were used to analyze the data. Ability to gain the trust of the patient, verbal and nonverbal communication skills, history taking, preparation of the patient for gynecological examination, and diagnosis and treatment of common diseases were significantly better in the SNAPPS group compared to the teacher-centered education group (P<0.05. The SNAPPS education method can significantly improve the clinical skills of midwifery students in gynecology, in particular history taking, differential diagnosis, and treatment of common diseases.

  5. Benign monomelic amyotrophy of lower limb: report of three cases. (United States)

    Uncini, A; Servidei, S; Delli Pizzi, C; Cutarella, R; Di Muzio, A; Gambi, D; Tonali, P


    Three patients with wasting confined to a single lower limb are reported. The characteristic features were: sporadic occurrence, insidious onset with slow progression and in 2 cases arrested course for at least 4 years, wasting out of proportion with disability, absence of sensory, pyramidal tract or bulbar signs. CK, motor and sensory conductions, and lumbar MRI were normal. Muscle CT showed selective loss of muscle tissue and fat replacement in posterior leg muscles. Quantitative electromyography and histologic findings revealed neurogenic features not only in the affected legs, but also in clinically uninvolved limbs. Monomelic amyotrophy of lower limb is a variant of spinal muscular atrophy with a benign course. However, as in the early stages of the disease there are no distinctive clinical or laboratory findings with other motor neuron diseases, the diagnosis of monomelic amyotrophy may be made only retrospectively after a prolonged observation.

  6. Serum uric acid, dehydroepiandrosterone sulphate, and apolipoprotein E genotype in benign vs. progressive multiple sclerosis

    NARCIS (Netherlands)

    Ramsaransing, GSM; Heersema, DJ; De Keyser, J


    The majority of patients with multiple sclerosis (MS) experience gradual progression of disability, either as secondary progressive MS (SPMS) or primary progressive MS (PPMS). A subgroup with relapsing-remitting MS shows a benign course with little or no disease progression and minimal disability de

  7. Induction of eruptive benign melanocytic naevi by immune suppressive agents, including biologicals.

    NARCIS (Netherlands)

    Bovenschen, H.J.; Tjioe, M.; Vermaat, H.; Hoop, D. de; Witteman, B.M.; Janssens, R.W.A.; Stoof, T.J.; Kerkhof, P.C.M. van de


    BACKGROUND: Eruptive naevi have been described to potentially arise in immune compromised patients. OBJECTIVES: We describe three patients with eruptive benign melanocytic naevi during a phase of immunosuppressive therapy. METHODS/DIAGNOSIS: Two patients with Crohn disease were treated with either a

  8. Increased Antioxidant Quality Versus Lower Quantity Of High Density Lipoprotein In Benign Prostatic Hyperplasia

    Directory of Open Access Journals (Sweden)

    Aydin Ozgur


    Full Text Available Background: Oxidative stress may be involved in the pathogenesis of every human disease. To understand its possible role in benign prostatic hyperplasia (BPH, we measured the overall oxidative status of patients with BPH and the serum activity of the high density lipoprotein (HDL-related antioxidant enzymes paraoxonase 1 (PON1 and arylesterase (ARE.


    Directory of Open Access Journals (Sweden)

    B. Surendiran


    Full Text Available Breast cancer is the primary and most common disease found in women which causes second highest rate of death after lung cancer. The digital mammogram is the X-ray of breast captured for the analysis, interpretation and diagnosis. According to Breast Imaging Reporting and Data System (BIRADS benign and malignant can be differentiated using its shape, size and density, which is how radiologist visualize the mammograms. According to BIRADS mass shape characteristics, benign masses tend to have round, oval, lobular in shape and malignant masses are lobular or irregular in shape. Measuring regular and irregular shapes mathematically is found to be a difficult task, since there is no single measure to differentiate various shapes. In this paper, the malignant and benign masses present in mammogram are classified using Hue, Saturation and Value (HSV weight function based statistical measures. The weight function is robust against noise and captures the degree of gray content of the pixel. The statistical measures use gray weight value instead of gray pixel value to effectively discriminate masses. The 233 mammograms from the Digital Database for Screening Mammography (DDSM benchmark dataset have been used. The PASW data mining modeler has been used for constructing Neural Network for identifying importance of statistical measures. Based on the obtained important statistical measure, the C5.0 tree has been constructed with 60-40 data split. The experimental results are found to be encouraging. Also, the results will agree to the standard specified by the American College of Radiology-BIRADS Systems.

  10. Interleukin-1α Is a Paracrine Inducer of FGF7, a Key Epithelial Growth Factor in Benign Prostatic Hyperplasia


    Giri, Dipak; Ittmann, Michael


    Benign prostatic hyperplasia (BPH) is an extremely common disease of older men in which there is benign overgrowth of the prostatic transition zone, leading to obstruction of urine outflow. FGF7, a potent growth factor for prostatic epithelial cells, is increased by threefold in BPH and is correlated with increased epithelial proliferation in this condition. Immunohistochemistry of normal and hyperplastic prostate revealed that FGF7-expressing fibroblastic cells were present in higher numbers...

  11. Identification of potential hot spots in the carboxy-terminal part of the Epstein-Barr virus (EBV) BNLF-1 gene in both malignant and benign EBV-associated diseases

    DEFF Research Database (Denmark)

    Sandvej, K; Peh, S C; Andresen, B S;


    In this study, we have sequenced the C-terminal part of the Epstein-Barr virus (EBV)-BNLF-1 gene encoding for the latent membrane protein-1 from tissues of EBV-positive Danish Hodgkin's disease (HD) and of Danish and Malaysian peripheral T-cell lymphomas (PTLs) and from tonsils of Danish infectious...

  12. Review of Prostate Anatomy and Embryology and the Etiology of Benign Prostatic Hyperplasia. (United States)

    Aaron, LaTayia; Franco, Omar E; Hayward, Simon W


    Prostate development follows a common pattern between species and depends on the actions of androgens to induce and support ductal branching morphogenesis of buds emerging from the urogenital sinus. The human prostate has a compact zonal anatomy immediately surrounding the urethra and below the urinary bladder. Rodents have a lobular prostate with lobes radiating away from the urethra. The human prostate is the site of benign hyperplasia, prostate cancer, and prostatitis. The rodent prostate has little naturally occurring disease. Rodents can be used to model aspects of human benign hyperplasia, but care should be taken in data interpretation and extrapolation to the human condition.

  13. Benign isolated histiocytosis mimicking chicken pox in a neonate: report of two cases with ultrastructural study. (United States)

    Valderrama, E; Kahn, L B; Festa, R; Lanzkowsky, P


    Two cases of benign isolated cutaneous histiocytosis X in newborn infants are reported. Clinically, the lesions mimicked chicken pox, and the histologic findings in skin biopsies were indistinguishable from those described in infantile Letterer-Siwe disease. Electron microscopy showed Langerhans' cells with the classical trilaminar, racket-shaped granules. Our cases a well as 10 of the 21 previously reported cases showed spontaneous resolution of the skin lesions. Since this is a benign spontaneous resolving histiocytosis, we recommend that no therapy be given provided that no other signs of systemic involvement are found.

  14. MR动态增强和扩散加权成像对前列腺良恶性病变的评价%MRI Dynamic Contrast-enhancement and Diffusion-weighted Imaging for Evaluation of Benign and Malignant Diseases of Prostates

    Institute of Scientific and Technical Information of China (English)

    陈自谦; 吴道清; 倪萍


    目的 探讨MR动态增强(DEC-MRI)及扩散加权成像(DWI)在前列腺良恶性病变诊断中的价值.方法 对83例经病理证实的前列腺疾病患者行MRI常规平扫、DWI及MR动态增强检查,同时将55例正常志愿者作为对照组,分析正常组、前列腺增生组(BPH)以及前列腺癌肿组(Pca)的前列腺的外周带和中央叶的DEC-MRI信号变化、SI-T曲线特征及DWI-ADC值的变化特点.结果 MR动态增强和DWI对前列腺良恶性疾病的枪出具有较高的敏感性和特异性.SI-T曲线的达峰时间(Tmax)从高到低依次为正常前列腺外周带、正常中央叶、BPH及Pca(P=0.000);强化程度(SI%)从高到低为BPH、正常中央叶、Pca及正常外周带(P=0.000);强化率(R)从高到低为Pca、BPH、正常中央叶及正常外周带(P=0.000).ADC值从高到低为正常外周带、正常中央叶、BPH及Pca(P=0.000).结论 MR动态增强及DWI可明显提高对前列腺良恶性疾病的诊断和鉴别诊断率.%Objective To evaluate the value of MRI dynamic contrast-enhancement (DCE-MRI) and diffusion-weighted imaging(DWI) in diagnosis of benign and malignant diseases of prostates. Methods 39 benign prostatic hyperplasia (BPH), 44 prostatic carcinoma (PCa) and 55 healthy volunteers proved by pathology were scanned with conventional MR imaging, MR dynamic enhancement and DWI. The alteration of DCE-MR1 signal intensity,the characteristics of signal intensity-time curve (SI-T curve) and the ADCs were analyzed. Results DCE-MRI and DWI played an important role in diagnosis of prostate diseases and had high sensitivity and specificity.The peak time(Tmax) of ranking from high to low was the normal peripheral and central gland zone of control group, BPH nodules and PCa focus(ρ=0.000) respectively .The enhancement rate was reverse(ρ=0.000).The enhancement degree of ranking from high to low was BPH nodules,the normal central gland, PCa focus and normal peripheral zone (ρ=0.000). The differences of inter

  15. Surgery for invasive gynecologic cancer in the elderly female population. (United States)

    Lawton, F G; Hacker, N F


    Radical, curative surgery may not be considered in elderly patients with gynecologic cancer, yet the morbidity for this population from radiotherapy and cytotoxics may be high. This study compared the feasibility and outcome of such surgery in 226 consecutive patients, 72 women over 70 years old and 154 younger patients, in our institution over a 26-month period. Older patients presented with more advanced-stage cancers and, as a group, had significantly poorer presurgical performance status and more intercurrent medical problems. Nevertheless, the planned radical surgical procedure could be carried out in 90% of elderly patients, with a postoperative mortality of 1.5%. Minor postoperative complication rates were similar for the two groups and, except for vulvectomy patients, the mean inpatient stay was the same for both groups. Chronological age alone is a poor determinant of surgical risk, and elderly patients withstand radical surgery almost as well as their younger counterparts.

  16. Combination Adriamycin and radiation therapy in gynecologic cancers

    Energy Technology Data Exchange (ETDEWEB)

    Watring, W.G.; Byfield, J.E.; Lagasse, L.D.; Lee, Y.D.; Juillard, G.; Jacobs, M.; Smith, M.L.


    Anthracyclic antibiotics, of which adriamycin is representative, have the ability to bind to cellular DNA and thereby interfere with the X ray repair process. When radiation survival curves of tissue cultures were studied, increased cell-killing was noted in those cultures with adriamycin over those without the drug. The mechanism by which this occurs may be related to a reduced rate of DNA strand break rejoining, as demonstrated by use of alkaline sucrose gradient techniques. A preliminary clinical Phase I study, in which patients with advanced gynecologic malignancy were treated by simultaneous adriamycin and X radiation, suggests that combined therapy is well-tolerated, and that such combinations may prove useful in selected patients.

  17. Effective feedback strategies for teaching in pediatric and adolescent gynecology. (United States)

    Kaul, Paritosh; Gong, Jennifer; Guiton, Gretchen


    The clinical setting of pediatric and adolescent gynecology poses complex tasks for the physician with its numerous procedures and the communication demands of interacting with an adolescent and/or guardian. Needless to say, teaching within this setting is highly demanding. Regardless of the level of learner or the professional role (e.g., nurse, medical student, resident, physician assistant) represented, clinical teaching requires that the instructor provide feedback in ways that benefit the student. Recent research on feedback suggests a more complex understanding of feedback than in the past. This article highlights key research and its implication for effective feedback by presenting a three part framework; know your learner, understand what is to be learned, and plan for improvement.

  18. Metformin in obstetric and gynecologic practice: a review. (United States)

    McCarthy, Elizabeth A; Walker, Susan P; McLachlan, Kylie; Boyle, Jacqui; Permezel, Michael


    Metformin is a common treatment for women who have insulin resistance manifesting as type 2 diabetes or polycystic ovarian syndrome (PCOS). With an increasing number of these patients conceiving, it is expected that the use of metformin in and around the time of pregnancy will increase. This article reassesses the mechanisms, safety, and clinical experience of metformin use in obstetrics and gynecology. Metformin is an attractive therapeutic option because administration is simple, hypoglycemia rare, and weight loss promoted. There is a large volume of research supporting the use of metformin treatment in diabetes mellitus, androgenization, anovulation, infertility, and recurrent miscarriage. Although metformin is known to cross the placenta, there is, as yet, no evidence of teratogenicity. Metformin has an array of complex actions, accounting for the varied clinical roles, many of which are still to be fully evaluated. Much research is still needed.

  19. Phytochemicals: a multitargeted approach to gynecologic cancer therapy. (United States)

    Farrand, Lee; Oh, Se-Woong; Song, Yong Sang; Tsang, Benjamin K


    Gynecologic cancers constitute the fourth most common cancer type in women. Treatment outcomes are dictated by a multitude of factors, including stage at diagnosis, tissue type, and overall health of the patient. Current therapeutic options include surgery, radiotherapy, and chemotherapy, although significant unmet medical needs remain in regard to side effects and long-term survival. The efficacy of chemotherapy is influenced by cellular events such as the overexpression of oncogenes and downregulation of tumor suppressors, which together determine apoptotic responses. Phytochemicals are a broad class of natural compounds derived from plants, a number of which exhibit useful bioactive effects toward these pathways. High-throughput screening methods, rational modification, and developments in regulatory policies will accelerate the development of novel therapeutics based on these compounds, which will likely improve overall survival and quality of life for patients.

  20. Benign Multicystic Mesothelioma in the Left Round Ligament: Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Bae, So Young; Yi, Boem Ha; Lee, Hae Kyung; Park, Seong Jin; Cho, Gyu Seok; Kwak, Jeong Ja [Soonchunhyang University Bucheon Hospital, Bucheon (Korea, Republic of)


    Benign multicystic mesothelioma is a rare mesothelial lesion that forms multicystic masses in the upper abdomen, pelvis, and retroperitoneum. Most cases have a benign course. We present the ultrasound and MR findings of benign multicystic mesothelioma in the left round ligament, which caused a left inguinal hernia in a 46-year-old woman.