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Sample records for belgian post-menopausal women

  1. Sleep in post-menopausal women: differences between early and late post-menopause.

    Science.gov (United States)

    Hachul, Helena; Bittencourt, Lia Rita Azeredo; Soares, José Maria; Tufik, Sergio; Baracat, Edmund Chada

    2009-07-01

    The aim of this study was to evaluate the differences in sleep between women of early and late post-menopause. Thirty post-menopausal women who came to the climacteric service of their own volition were selected. Fourteen were in early post-menopause (less than 5 years after menopause), and sixteen were in late post-menopause (more than 5 years since menopause). None of the women were suffering from any other clinical diseases. Participants had no previous history of hormone therapy or hypnotic drug use. These patients were not previously selected with regard to any sleep complaints. All participants answered a sleep questionnaire and underwent a polysomnography recording. Subjective complaints included body pain, bruxism, anxiety, depression, lack of concentration, and sleepiness (measured by the Epworth Sleepiness Scale). These complaints were more frequent in the late post-menopause group. In contrast, complaints of memory impairment were more frequent in the early post-menopause group (psleep were higher in the late post-menopausal group.

  2. Why Do Only Some Women Develop Post-Menopausal Osteoporosis?

    Science.gov (United States)

    2015-05-01

    AWARD NUMBER: W81XWH-13-1-0307 TITLE: Why Do Only Some Women Develop Post- Menopausal Osteoporosis ? PRINCIPAL INVESTIGATOR: Marc D...Only Some Women Develop Post-Menopausal Osteoporosis ? 5a. CONTRACT NUMBER 5b. GRANT NUMBER W81XWH-13-1-0307 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S...proposed project addresses a novel and potentially important mechanism of osteoporosis which may determine which women suffer the disease. Confirmation

  3. Validity and reproducibility of a self-administered semi-quantitative food-frequency questionnaire for estimating usual daily fat, fibre, alcohol, caffeine and theobromine intakes among Belgian post-menopausal women.

    Science.gov (United States)

    Bolca, Selin; Huybrechts, Inge; Verschraegen, Mia; De Henauw, Stefaan; Van de Wiele, Tom

    2009-01-01

    A novel food-frequency questionnaire (FFQ) was developed and validated to assess the usual daily fat, saturated, mono-unsaturated and poly-unsaturated fatty acid, fibre, alcohol, caffeine, and theobromine intakes among Belgian post-menopausal women participating in dietary intervention trials with phyto-oestrogens. The relative validity of the FFQ was estimated by comparison with 7 day (d) estimated diet records (EDR, n 64) and its reproducibility was evaluated by repeated administrations 6 weeks apart (n 79). Although the questionnaire underestimated significantly all intakes compared to the 7 d EDR, it had a good ranking ability (r 0.47-0.94; weighted kappa 0.25-0.66) and it could reliably distinguish extreme intakes for all the estimated nutrients, except for saturated fatty acids. Furthermore, the correlation between repeated administrations was high (r 0.71-0.87) with a maximal misclassification of 7% (weighted kappa 0.33-0.80). In conclusion, these results compare favourably with those reported by others and indicate that the FFQ is a satisfactorily reliable and valid instrument for ranking individuals within this study population.

  4. Validity and Reproducibility of a Self-Administered Semi-Quantitative Food-Frequency Questionnaire for Estimating Usual Daily Fat, Fibre, Alcohol, Caffeine and Theobromine Intakes among Belgian Post-Menopausal Women

    Directory of Open Access Journals (Sweden)

    Selin Bolca

    2009-01-01

    Full Text Available A novel food-frequency questionnaire (FFQ was developed and validated to assess the usual daily fat, saturated, mono-unsaturated and poly-unsaturated fatty acid, fibre, alcohol, caffeine, and theobromine intakes among Belgian post-menopausal women participating in dietary intervention trials with phyto-oestrogens. The relative validity of the FFQ was estimated by comparison with 7 day (d estimated diet records (EDR, n 64 and its reproducibility was evaluated by repeated administrations 6 weeks apart (n 79. Although the questionnaire underestimated significantly all intakes compared to the 7 d EDR, it had a good ranking ability (r 0.47-0.94; weighted κ 0.25-0.66 and it could reliably distinguish extreme intakes for all the estimated nutrients, except for saturated fatty acids. Furthermore, the correlation between repeated administrations was high (r 0.71-0.87 with a maximal misclassification of 7% (weighted κ 0.33-0.80. In conclusion, these results compare favourably with those reported by others and indicate that the FFQ is a satisfactorily reliable and valid instrument for ranking individuals within this study population.

  5. Relationship between sleep quality and cardiovascular disease risk in Chinese post-menopausal women

    OpenAIRE

    Chair, Sek Ying; Wang, Qun; Cheng, Ho Yu; Lo, Sally Wai-Sze; Li, Xiao Mei; Wong, Eliza Mi-Ling; Sit, Janet Wing-Hung

    2017-01-01

    Background Menopause is an inevitable stage affecting every middle-aged woman. China has a large and increasing group of post-menopausal women. Most post-menopausal women suffer from increased risks for cardiovascular diseases (CVD) and sleep problems. Previous studies have demonstrated the associations between sleep disorders and increased CVD risks in general population. The current study is to examine the relationship between sleep quality and CVD risks among Chinese post-menopausal women....

  6. Adiposity, insulin and lipid metabolism in post-menopausal women.

    Science.gov (United States)

    Lovegrove, J A; Silva, K D R R; Wright, J W; Williams, C M

    2002-04-01

    To investigate relationships between body fat and its distribution and carbohydrate and lipid tolerance using statistical comparisons in post-menopausal women. Sequential meal, postprandial study (600 min) which included a mixed standard breakfast (30 g fat) and lunch (44 g fat) given at 0 and 270 min, respectively, after an overnight fast. Twenty-eight post-menopausal women with a diverse range of body weight (body mass index (BMI), mean 27.2, range 20.5-38.8 kg/m2) and abdominal fat deposition (waist, mean 86.4, range 63.5-124.0 cm). Women with BMI 37 kg/m2, age > 80 y and taking hormone replacement therapy (HRT) were excluded. Anthropometric measurements were performed to assess total and regional fat deposits. The concentrations of plasma total cholesterol, high density lipoprotein (HDL) cholesterol, triacylglycerol (TAG), glucose, insulin (ins), non-esterified fatty acids (NEFA) and apolipoprotein (apo) B-48 were analysed in plasma collected at baseline (fasted state) and at 13 postprandial time points for a 600 min period. Insulin concentrations in the fasted and fed state were significantly correlated with all measures of adiposity (BMI, waist, waist-hip ratio (W/H), waist-height ratio (W/Ht) and sum of skinfold thickness (SSk)). After controlling for BMI, waist remained significantly and positively associated with fasted insulin (r=0.559) with waist contributing 53% to the variability after multiple regression analysis. After controlling for waist, BMI remained significantly correlated with postprandial (IAUC) insulin (r=0.535) contributing 66% of the variability of this measurement. No association was found between any measures of adiposity and glucose concentrations, although insulin concentration in relation to glucose concentration (glucose-insulin ratio) was significantly negatively correlated with all measures of adiposity. A significant positive correlation was found between fasted TAG and BMI (r=0.416), waist (r=0.393) and Ssk (r=0.457) and

  7. Calcium and vitamin D in post menopausal women

    Directory of Open Access Journals (Sweden)

    Sameer Aggarwal

    2013-01-01

    Full Text Available Calcium and Vitamin D are widely used therapies for Osteoporosis. Vitamin D is not a vitamin in true sense since it is produced in response to the action of sunlight on skin. Vitamin D has multiple roles in the body, not all of them well-understood. Vitamin D supplementation must be considered a form of hormone replacement therapy. Therefore it raises all the questions about efficacy, dose, and side effects. The Efficacy of use of Calcium and Vitamin D in all post menopausal women in terms of the prevention of fracture is uncertain. The Annual worldwide sales of these supplements have been several billion dollars. The variation of the results from various studies of Calcium and Vitamin D supplementation in elderly women suggest that benefit of calcium plus vitamin D on bone mineral density or the risk of fracture is small and may vary from group to group and baseline Vitamin D status. Women taking supplemental vitamin D and calcium have a statistically increased incidence of renal stones, according to evidence from the Women′s Health Initiative. Studies have shown association between calcium use and increased risk for cardiovascular disease. In a recent review of evidence from 6 randomized trials evaluating the use of vitamin D and calcium to prevent fractures in postmenopausal women who are not living in a nursing home or other institution, the United States Preventive Task Force (USPTF found no evidence of a benefit from supplementation with 400 IU or less of vitamin D3 and 1000 mg or less of calcium. Also in a report from institute of Medicine Committee, there was insufficient evidence, particularly from randomized trials, that vitamin D treatment affected the risk of non skeletal outcomes like risk of cancer, cardiovascular disease, diabetes, infections, autoimmune disease, and other extra skeletal outcomes.

  8. CT measurement of fat in pre- and post-menopausal women with breast cancer

    International Nuclear Information System (INIS)

    Sato, Masanori; Ogura, Toshihiro

    2011-01-01

    Since breast cancer is the most common cancer among Japanese women, research leading to its prevention and early detection is important, and many studies have reported a relationship between this cancer and obesity. In addition, it has been reported that the risk of breast cancer posed by obesity differs between pre- and post-menopausal patients. In this study, we investigated the difference in the amount of body fat between pre- and post-menopausal breast cancer patients by measuring the areas of total, visceral, and subcutaneous fat on CT images acquired at the level of the umbilicus. The subjects were 136 women, comprising 63 with breast cancer (21 pre- and 42 post-menopausal) and 73 with other diseases (31 pre- and 42 post menopausal). We found that post-menopausal women with breast cancer had a significantly greater amount of fat than their pre-menopausal counterparts, presumably attributable to the action of estrogen. These results suggest that fat accumulation in post-menopausal women increases the risk of breast cancer. (author)

  9. Oestrogen therapy for urinary incontinence in post-menopausal women.

    Science.gov (United States)

    Cody, June D; Jacobs, Madeleine Louisa; Richardson, Karen; Moehrer, Birgit; Hextall, Andrew

    2012-10-17

    It is possible that oestrogen deficiency may be an aetiological factor in the development of urinary incontinence in women. This is an update of a Cochrane review first published in 2003 and subsequently updated in 2009. To assess the effects of local and systemic oestrogens used for the treatment of urinary incontinence. We searched the Cochrane Incontinence Group Specialised Register of trials (searched 21 June 2012) which includes searches of MEDLINE, the Cochrane Central Register of Controlled Trials (CENTRAL) and handsearching of journals and conference proceedings, and the reference lists of relevant articles. Randomised or quasi-randomised controlled trials that included oestrogens in at least one arm in women with symptomatic or urodynamic diagnoses of stress, urgency or mixed urinary incontinence or other urinary symptoms post-menopause. Trials were evaluated for risk of bias and appropriateness for inclusion by the review authors. Data were extracted by at least two authors and cross checked. Subgroup analyses were performed by grouping participants under local or systemic administration. Where appropriate, meta-analysis was undertaken. Thirty-four trials were identified which included approximately 19,676 incontinent women of whom 9599 received oestrogen therapy (1464 involved in trials of local vaginal oestrogen administration). Sample sizes of the studies ranged from 16 to 16,117 women. The trials used varying combinations of type of oestrogen, dose, duration of treatment and length of follow up. Outcome data were not reported consistently and were available for only a minority of outcomes.The combined result of six trials of systemic administration (of oral systemic oestrogens) resulted in worse incontinence than on placebo (risk ratio (RR) 1.32, 95% CI 1.17 to 1.48). This result was heavily weighted by a subgroup of women from the Hendrix trial, which had large numbers of participants and a longer follow up of one year. All of the women had had a

  10. Endurance exercise training enhances cutaneous microvascular reactivity in post-menopausal women.

    Science.gov (United States)

    Tew, Garry A; George, Keith P; Cable, N Tim; Hodges, Gary J

    2012-03-01

    To compare cutaneous microvascular reactivity between untrained young and post-menopausal women, and assess the effects of 48 weeks of endurance exercise training on cutaneous microvascular reactivity in post-menopausal women. Twenty post-menopausal and 12 young women completed this study. Using laser-Doppler flowmetry, an index of skin blood flow was measured on the forearm at rest, during post-occlusive reactive hyperaemia (PORH), and during localised heating to 42°C. Cutaneous vascular conductance (CVC) was calculated as the ratio of laser-Doppler flow to mean arterial pressure (in AU mm Hg(-1)). For the post-menopausal women, this assessment was also performed after 6, 12, 24, 36, and 48 weeks of endurance exercise training. PORH and maximum CVC responses were depressed in untrained post-menopausal women compared with young controls (P ≤ 0.011 for all methods of data expression). PORH was increased (Ptraining (0.51 ± 0.16 vs. 0.65 ± 0.23 AU mm Hg(-1)), with further increases after 36 and 48 weeks (0.76 ± 0.27 and 0.88 ± 0.32 AU mm Hg(-1), respectively). Similarly, maximum CVC was increased (Ptraining, the PORH and maximum CVC responses of the post-menopausal women did not differ to those of the young untrained women (P>0.05). Cutaneous microvascular reactivity is reduced in post-menopausal women compared to young controls and increased to similar levels after 24-36 weeks of mild-to-moderate endurance exercise. Copyright © 2011 Elsevier Inc. All rights reserved.

  11. An exploratory comparison of vaginal glycogen and Lactobacillus levels in pre- and post-menopausal women

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    Mirmonsef, Paria; Modur, Sharada; Burgad, Derick; Gilbert, Douglas; Golub, Elizabeth T.; French, Audrey L.; McCotter, Kerrie; Landay, Alan L.; Spear, Greg T.

    2014-01-01

    Objective Previous studies have suggested that glycogen expression in vaginal epithelium decreases at menopause, resulting in reduced levels of lactobacilli. However, free glycogen in genital fluids and its relationship to Lactobacillus levels has not been compared in pre- and post-menopausal women. Methods 82 cervico-vaginal lavage samples were collected at different phases of the menstrual cycle from 11 pre-menopausal (4 HIV-uninfected and 7 HIV-infected) and 12 post-menopausal (7 HIV-uninfected and 5 HIV-infected) women over a 1–3 month period. Free glycogen was quantified in genital fluid. Lactobacillus levels were quantified by real time PCR. Estrogen and progesterone levels in blood were determined by ELISA. Results Free glycogen was detected in both pre- and post-menopausal women. Across all samples, those from post-menopausal women had significantly lower levels of free glycogen than those from pre-menopausal women (median 0.002 vs. 0.065 µg/µl, respectively; p = 0.03). Lactobacillus levels correlated positively with free glycogen in both pre- (Spearman r=0.68, p Free glycogen was detected in both pre- and post-menopausal women and correlated with Lactobacillus in both groups. These results point to the complexity of the relationship between menopause and vaginal microbiota and indicate that more careful studies of the role played by glycogen are warranted. PMID:25535963

  12. Biomarkers of vascular function in pre- and recent post-menopausal women of similar age

    DEFF Research Database (Denmark)

    Nyberg, Michael Permin; Seidelin, Kåre; Rostgaard Andersen, Thomas

    2014-01-01

    Menopause is associated with an accelerated decline in vascular function, however, whether this is an effect of age and/or menopause and how exercise training may affect this decline remains unclear. We examined a range of molecular measures related to vascular function in matched pre- and post-menopausal...... women before and after 12 weeks of exercise training. Thirteen pre-menopausal and ten recently post-menopausal (1.6±0.3 (mean±SEM) years after final menstrual period) women only separated by three years (48±1 vs. 51±1 years) were included. Before training, diastolic blood pressure, soluble intercellular...... adhesion molecule-1 (sICAM-1) and skeletal muscle expression of thromboxane A synthase were higher in the post-menopausal women compared to the pre-menopausal women, all indicative of impaired vascular function. In both groups, exercise training lowered diastolic blood pressure, the levels of sICAM-1...

  13. Body fat distribution in pre-and post-menopausal women: metabolic and anthropometric variables.

    Science.gov (United States)

    Garaulet, M; Pérez-Llamas, F; Baraza, J C; Garcia-Prieto, M D; Fardy, P S; Tébar, F J; Zamora, S

    2002-01-01

    Abdominal obesity is associated with coronary risk although the causality is not well established. To compare body fat distribution and metabolic variables in obese pre- and post- menopausal women. The study was conducted in 55 obese female subjects (22 pre- and 33 post- menopausal) with body mass indices (BMI) from 27 to 35 Kg/m2. Body fat distribution was measured using waist and hip circumference and computerized tomography. Hormones such as estradiol, testosterone, androstenedione, dehydroepiandrosterone-sulfate, as well as plasma lipids such as triglycerides, total cholesterol, high density lipoprotein, low density lipoprotein, apoproteins A and B, were also determined. No significant differences were found between the two groups in BMI, percentage of body fat, waist circumference, triceps, biceps, suprailiac and abdominal skinfolds. Hip circumference, subscapular skinfold and subcutaneous abdominal adipose tissue area were significantly lower, and waist-hip ratio, visceral area and visceral to subcutaneous area ratios significantly higher in post- menopausal women (P low density lipoprotein, values were significantly higher in the post-menopausal group (P fat distribution changes according to menopausal status, with central obesity more pronounced in post- menopausal women. Metabolic abnormalities are related more to visceral adipose tissue and estrogen plasma levels than to BMI.

  14. Critical review of health effects of soyabean phyto-oestrogens in post-menopausal women

    DEFF Research Database (Denmark)

    Cassidy, A.; Albertazzi, P.; Nielsen, I. L.

    2006-01-01

    A consensus view of soyabean phyto-oestrogens in clinical interventions in post-menopausal women is presented that is based on data from the EU-funded project Phytohealth. The phyto-oestrogens, primarily genistein and daidzein, were given as soyabean-protein isolates, whole-soyabean foods...... or extracts, supplements or pure compounds. A comprehensive literature search was conducted with well-defined inclusion or exclusion criteria. For areas for which substantial research exists only placebo-controlled double-blind randomised controlled trials (RCT) conducted on healthy post-menopausal women were...... included. For emerging areas all available human studies in post-menopausal women were reviewed. In order to make cross comparisons between studies the doses of isoflavones were calculated as aglycone equivalents. There is a suggestion, but no conclusive evidence, that isoflavones from the sources studied...

  15. Alzheimer disease in post-menopausal women: Intervene in the critical window period

    Directory of Open Access Journals (Sweden)

    Nayer Jamshed

    2014-01-01

    Full Text Available Alzheimer disease (AD is a crippling neurodegenerative disorder. It is more common in females after menopause. Estrogen probably has a protective role in cognitive decline. Large amount of research has been carried out to see the benefits of hormone replacement therapy with regards to Alzheimer still its neuroprotective effect is not established. Recent studies suggest a reduced risk of AD and improved cognitive functioning of post-menopausal women who used 17 β-estradiol in the critical period. Use of 17 β-estradiol in young and healthy post-menopausal women yields the maximum benefit when the neurons are intact or neuronal stress has just started. Hence intervention in the critical period is key in the prevention or delay of AD in post-menopausal women.

  16. Relationship between sleep quality and cardiovascular disease risk in Chinese post-menopausal women.

    Science.gov (United States)

    Chair, Sek Ying; Wang, Qun; Cheng, Ho Yu; Lo, Sally Wai-Sze; Li, Xiao Mei; Wong, Eliza Mi-Ling; Sit, Janet Wing-Hung

    2017-09-11

    Menopause is an inevitable stage affecting every middle-aged woman. China has a large and increasing group of post-menopausal women. Most post-menopausal women suffer from increased risks for cardiovascular diseases (CVD) and sleep problems. Previous studies have demonstrated the associations between sleep disorders and increased CVD risks in general population. The current study is to examine the relationship between sleep quality and CVD risks among Chinese post-menopausal women. This study was a sub-study nested in a cross-sectional study that investigated the sleep quality of community-dwelling adults in Xian, Shaanxi Province, China. The Chinese version of the Pittsburgh Sleep Quality Index (PSQI) and the Framingham 10-year risk score (FRS) were used to measure sleep quality and CVD risk among 154 Chinese post-menopausal women. Multivariate regression and logistic regression were used to determine the association between sleep quality and CVD risk. The participants (age: 63.65 ± 4.47 years) experienced poor sleep quality (mean score of global PSQI = 8.58) and a 10-year risk of CVD of 12.54%. The CVD risk was significantly associated with sleep duration (β = - 0.18, p = 0.04) and sleep disturbance (β = 0.33, p sleep quality (PSQI ≤5) were less likely to be at high risk for CVD (FRS > 10%) (odds ratio = 0.51, p = 0.04). Poor sleep quality might increase the CVD risk in post-menopausal women. Interventions to promote the cardiovascular health of Chinese post-menopausal women may need to include sleep promotion strategies.

  17. Tooth Loss and Perceived Masticatory Ability in Post-Menopausal Women

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    Bunga Riadiani

    2014-10-01

    Full Text Available Post-menopausal women experience physiological hormonal changes that reduce bone density which leads to tooth loss and presumably affect masticatory function. Objective: This study aims to determine association between tooth loss and masticatory ability in post-menopausal women. Methods: Cross sectional study of 95 post-menopausal women at Posbindu Lansia Pergeri Depok, West Java was performed. Subjects answered questionnaires and intra oral examination was performed. Chi square analysis was conducted to relate age, menopausal period, education level, tooth loss and denture use with masticatory ability. Results: 47% subjects lost >10 teeth, 27% subjects lost 6-10 teeth and 26% subjects lost <6 teeth. Seventy-six percent of subjects did not wear dentures. Menopausal period, tooth loss, and age had significant correlation with masticatory ability (p<0.05. Conclusions: This study concludes that masticatory ability in post-menopausal women is significantly affected by length of menopausal period, tooth loss and age (p<0.05.

  18. Understanding the relation between socioeconomic position and inflammation in post-menopausal women

    DEFF Research Database (Denmark)

    Pedersen, Jolene Masters; Budtz-Jørgensen, Esben; De Roos, Anneclaire

    2017-01-01

    of education, income and occupational prestige on C-reactive protein (CRP) and to describe the relationship between these markers and CRP. Methods: The study was based on 2026 post-menopausal women enrolled in the Women’s Health Initiative-Observational Study. Occupational prestige was determined by linking...

  19. Study on the serum prolactin (PRL) level in post-menopausal women

    International Nuclear Information System (INIS)

    Li Wenqi; Li Xin; Zhou Jiwen; Zhou Zhengli

    2004-01-01

    Objective: To explore the clinical value of determination of serum PRL levels inpost-menopausal women. Methods: Serum PRL levels were determined with RIA in 596 post-menopausal women (age 45-59, mean 55). Results: The normal range of serum PRL level in this laboratory was 0-30 ng/ml. Among the 596 women tested, 77(13%) had their PRL levels above 30 ng/ml. Further investigation with CT and/or MRI revealed presence of micro-pituitary-adenoma in 31 of the Symptoms of menopausal syndrome and osteoporosis were much more severe in women with hyperprolactinemia then in those without. Conclusion: As hyperprolactinemia might be a high risk factor for development of breast cancer, hormone replacement therapy (HRT) in menopausal women with hyperprolactinemia should be applied very cautiously, even withheld at all. Determination of serum prolactin levels in post-menopausal women is of practical clinical value. (authors)

  20. Calcium status in premenopausal and post menopausal women

    International Nuclear Information System (INIS)

    Qureshi, H.J.; Hussain, G.; Bashir, M.U.; Latif, N.; Riaz, Z.

    2010-01-01

    Background: In postmenopausal women, the two major causes of bone loss are oestrogen deficiency after menopause and age related processes. Bone turnover increases to high levels and oestrogen deficiency may induce calcium loss by indirect effects on extra skeletal calcium homeostasis. Objective of this study was to evaluate calcium status in pre-menopausal and postmenopausal women. Methods: This cross sectional study was carried out in 34 premenopausal women and 33 postmenopausal women, in Department of Physiology, Services Institute of Medical Sciences, Lahore. Height and weight of each woman were taken to find out the body mass index (BMI). Serum calcium, parathyroid hormone and calcitonin levels of each subject were determined. Results: Premenopausal women were obese (BMI>30 Kg/m/sup 2/) while postmenopausal women were overweight (BMI>25 Kg/m/sup 2/). Serum calcium levels were significantly lower in postmenopausal women than in pre-menopausal women, while serum parathyroid hormone levels were significantly higher in postmenopausal woman. Serum calcitonin level was not significantly different in the two groups. Conclusion: Postmenopausal women are calcium deficient and have increased bone turnover as indicated by increased serum parathyroid hormone levels. (author)

  1. Periodontal status in post-menopausal osteoporosis: a preliminary clinical study in Taiwanese women.

    Science.gov (United States)

    Shen, E-Chin; Gau, Ching-Hwa; Hsieh, Yao Dung; Chang, Cheng-Yang; Fu, Earl

    2004-08-01

    Osteoporosis and periodontitis are common diseases affecting post-menopausal women; however, the exact relationship between the diseases is still uncertain. The purposes of this study were to examine the periodontal status in a group of type I post-menopausal women with and without osteoporosis and to elucidate the possible role of the osteoporosis in the pathogenesis of periodontal disease. Thirty-four patients (18 in the osteoporotic and 16 in the non-osteoporotic group) were selected from 329 post-menopausal Taiwanese women who had completed radiographic measurements of spinal bone mineral density and received full-mouth periodontal examination. Periodontal measurements, including O'Leary plaque index, probing depths, clinical attachment level, and gingival recession, on 6 sites of each tooth of full mouth were examined and recorded by 1 examiner. Significantly greater probing depth was noted at the interproximal, but not at the facio-lingual, osteoporotic sites if compared to those non-osteoporotic sites. The depth was also significantly influenced by the examining factors of plaque accumulation, tooth location, and jaws. By individual jaw, increased attachment loss accompanied by greater probing depth and gingival recession was found at the osteoporotic sites on mandible if compared to non-osteoporotic sites. On maxilla, however, less gingival recession and attachment loss were observed at the osteoporotic sites. In the present study, increased attachment loss accompanied by greater probing depth and gingival recession was found at the osteoporotic sites on mandible. However, the parameters were also influenced by the examining factors of plaque accumulation, tooth location, and jaws. Therefore, we suggest that post-menopausal osteoporosis may play a role in the pathogenesis of periodontal disease, especially on the mandible, although the etiology of periodontal disease is still multi-factorial.

  2. [Lifestyles and quality of life of post menopausal women].

    Science.gov (United States)

    López-Alegría, Fanny; De Lorenzi, Dino Roberto Soares

    2011-05-01

    During menopause the quality of life of women can be seriously deteriorated and influenced by lifestyles. To assess the prevalence of menopausal symptoms and their relationship with lifestyles and quality of life. The Menopause Rating Scale (MRS), a survey that measures menopausal symptoms and has questions related to lifestyles, was applied to 1023 women aged 54 ± 6 years (range 45 to 64 years), consulting in primary health care clinics. A multiple linear regression analysis was used to evaluate the association between menopausal symptoms and lifestyle. Fifty six percent of women did not have a paid work, 64% were nonsmokers and 90% did not perform any physical exercise. The most frequent menopausal symptoms referred were muscle and joint ailments (85%) followed by mental and physical exhaustion (80%). Sedentary women, smokers or those who did not to have time for leisure activities showed worst quality of life scores. Postmenopausal women with unhealthy lifestyles had the lower quality of life scores and more menopausal symptoms.

  3. Analysis of lipid status, body mass index and waist-hip ratio in post-menopausal women

    Directory of Open Access Journals (Sweden)

    Lejla Mešalić

    2012-09-01

    Full Text Available Introduction: Menopause is the absence of menses in the period longer that one year. It is widely accepted that menopause leads to changes in hormonal status, metabolism and lipid profi le. The aim of this study wasto analyze the infl uence of menopause on the concentrations of lipids, lipoproteins and also the influence of body mass index (BMI and waist-hip ratio (WHR on lipid profi le in post-menopausal women.Methods: Sixty post-menopausal women of average age of 52.82 years were compared to a group of 34 pre-menopausal women average age of 47.92 years.Results: Post-menopausal women had higher, but non signifi cant (p>0.05 concentrations of total cholesterol, very low density lipoproteins (VLDL, low density lipoproteins (LDL and triglycerides than pre-menopausal women. The concentration of high density lipoproteins (HDL was significantly lower in post-menopausal women than pre-menopausal (pbut without signifi cance (p>0.05. There was no difference between body mass index (BMI and waste-hip ratio (WHR, but the WHR has shown as a signifi cant predictor of the LDL and cholesterol concentrations inpost-menopausal women.Conclusion: We can conclude that menopause leads to changes in lipid profi le by lowering of HDL and increasing the levels of apolipoprotein B, that increases the risk for cardiovascular disease. The WHR is thesignifi cant predictor of cardiovascular risk in post-menopausal women.

  4. Rice Bran Extract Reduces the Risk of Atherosclerosis in Post-Menopausal Vietnamese Women.

    Science.gov (United States)

    Nhung, Bui Thi; Tuyen, Le Danh; Linh, Vu Anh; Anh, Nguyen Do Van; Nga, Tran Thuy; Thuc, Vu Thi Minh; Yui, Kei; Ito, Yukihiko; Nakashima, Yuri; Yamamoto, Shigeru

    2016-01-01

    We investigated whether pre-germinated brown rice bran extract containing acylated steryl glucosides (PSG) reduces the risk of atherosclerosis in post-menopausal Vietnamese women. A total of 60 post-menopausal Vietnamese women (45-65 y old) with high LDL cholesterol levels (over 140 mg/dL) were randomly divided into PSG (n=30) and placebo (n=30) groups. The subjects in the PSG group were assigned a daily intake of 6 capsules containing 50 mg PSG, and the subjects in the placebo group were assigned a daily intake of 6 capsules containing corn oil for 6 mo. Before baseline and after month 2, month 4, and month 6 of the intervention, we conducted anthropometric measurements, blood biochemical examinations, a nutrition survey, and physical activity, flow-mediated dilation (FMD), and cardio-ankle vascular index (CAVI) measurements. Serum LDL cholesterol concentrations were significantly reduced from 163.6±25.3 (mg/dL) to 135.9±26.8 (mg/dL) compared to the placebo group (p<0.001). FMD values of the placebo group were significantly reduced from 6.6±5.1 (%) to 4.7±2.6 (%) compared to the PSG group (p<0.05). Tumor necrosis factor (TNF)-α concentrations in the PSG group were significantly reduced from 19.8±11 (pg/mL) to 10.6±5.5 (pg/mL) compared to the placebo group (p<0.05). The findings suggest that PSG may improve LDL cholesterol, TNF-α levels, and FMD values. PSG might be considered in reducing the risk of atherosclerosis in post-menopausal Vietnamese women with high LDL cholesterol.

  5. Serum lipid responses to psyllium fiber: differences between pre- and post-menopausal, hypercholesterolemic women

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    Kuo Jennifer

    2008-08-01

    Full Text Available Abstract Background Cardiovascular disease is the leading cause of death in women and men. Psyllium, a soluble fiber has been known to reduce serum lipids. In this pilot study, we evaluated whether menopausal status would affect the serum lipid responses to psyllium fiber in women. Methods Eleven post-menopausal and eight pre-menopausal women with serum total cholesterol >200 mg/dL were included in the study. Subjects consumed their habitual diet and 15 g psyllium/d for 6 weeks. Psyllium was incorporated into cookies. Each cookie contained ≈5 g of psyllium fiber. Subjects ate one cookie in each meal. Results With psyllium fiber, total cholesterol concentration was significantly lower (≈5.2%, P Conclusion In this pilot study, post- and pre-menopausal, hypercholesterolemic women responded differently to psyllium fiber supplementation. Post-menopausal women would benefit from addition of psyllium to their diets in reducing the risk for heart diseases. The results of this study should be used with caution because the study was based on a small sample size.

  6. Analysis of lipid status, body mass index and waist-hip ratio in post-menopausal women

    Directory of Open Access Journals (Sweden)

    Lejla Mešalić

    2012-09-01

    Full Text Available Introduction: Menopause is the absence of menses in the period longer that one year. It is widely accepted that menopause leads to changes in hormonal status, metabolism and lipid profi le. The aim of this study wasto analyze the infl uence of menopause on the concentrations of lipids, lipoproteins and also the influence of body mass index (BMI and waist-hip ratio (WHR on lipid profi le in post-menopausal women.Methods: Sixty post-menopausal women of average age of 52.82 years were compared to a group of 34 pre-menopausal women average age of 47.92 years.Results: Post-menopausal women had higher, but non signifi cant (p>0.05 concentrations of total cholesterol, very low density lipoproteins (VLDL, low density lipoproteins (LDL and triglycerides than pre-menopausal women. The concentration of high density lipoproteins (HDL was significantly lower in post-menopausal women than pre-menopausal (p<0.05. The concentration of apolipoprotein B was also signifi cantly higher in post-menopausal women (p<0.05, but the concentrations of apolipoprotein and lipoprotein (a were lowerbut without signifi cance (p>0.05. There was no difference between body mass index (BMI and waste-hip ratio (WHR, but the WHR has shown as a signifi cant predictor of the LDL and cholesterol concentrations inpost-menopausal women.Conclusion: We can conclude that menopause leads to changes in lipid profi le by lowering of HDL and increasing the levels of apolipoprotein B, that increases the risk for cardiovascular disease. The WHR is thesignifi cant predictor of cardiovascular risk in post-menopausal women.

  7. Ribociclib for post-menopausal women with HR+/HER2- advanced or metastatic breast cancer.

    Science.gov (United States)

    Zangardi, Mark L; Spring, Laura M; Blouin, Gayle C; Bardia, Aditya

    2017-11-01

    The introduction of CDK4/6 inhibitors, such as ribociclib, has changed the treatment landscape for post-menopausal women with HR+/HER2- advanced or metastatic breast cancer. As first-line treatment of HR+/HER2- MBC, the addition of a CDK4/6 inhibitor to an aromatase inhibitor improves progression-free survival compared to an aromatase inhibitor alone. Areas covered: In this drug profile, we review the current market for HR+/HER2- MBC, as well as the characteristics, mechanism, pharmacology, pharmacodynamics, pharmacokinetics, metabolism, clinical efficacy, toxicities, monitoring, and dosing modification of the CDK4/6 inhibitor ribociclib. Expert commentary: CDK4/6 inhibitors, such as ribociclib, improve outcomes in post-menopausal women with HR+/HER2- MBC. The most common toxicity of ribociclib is neutropenia, which is generally not complicated and can be managed with dose modification and/or supportive care measures. Additional research will help better define the optimal clinical use of ribociclib.

  8. Assessment of bone mineral density with dual energy X-ray absorptiometry in pre-and post-menopausal women

    International Nuclear Information System (INIS)

    Salamat, M. R.; Rostampour, N.; Shanehsazzadeh, S.; Tavakoli, M. B.; Siavash, M.; Almasi, T.

    2008-01-01

    Osteoporosis is a chronic disease that contributes substantially to decrease physical activity and decline in the quality of life. Osteoporosis can be diagnosed easily with the use of dual-energy X-ray absorptiometry equipment. The aim of this study was to investigate the magnitude of bone loss on proximal femur and lumbar spine in pre-and post-menopausal women from Isfahan Osteoporosis Diagnosis Center since 2005. Materials and Methods: Bone mineral density measurements using dual-energy X-ray absorptiometry have been performed at Isfahan Osteoporosis Diagnosis Center. 185 pre-menopausal and 174 early post-menopausal women were selected randomly. A Norland XR46 system was used for the investigations. The student t-lest was done to find the difference between the T-scores of the femoral neck and lumbar spine in pre-and post-menopausal women. Results: Mean Bone mineral density for the femoral neck and lumbar spine in pre-menopausal women were 0.859 ± 0.136 and 1.012 ± 0.161 and in post-menopausal women were 0.816 ± 0.119 and 0.919 ± 0.140, respectively. Long-term Bone mineral density CVs of 1.0% and 1.2% for the lumbar spine and femoral neck were found, respectively. The differences between the femoral neck and lumbar spine for pre-and post-menopausal women were t = -9.02, P < 0.05 and t = -3.50, P < 0.05, respectively. Conclusion: In spite of, the reported lower Bone mineral density T-scores for the lumbar spine compared With the femoral neck for women, we found that the femoral neck had significantly lower T-score than lumbar spine for both pre-and post-menopausal women.

  9. Expression of estrogen receptors in the pelvic floor of pre- and post-menopausal women presenting pelvic organ prolapse

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    Marie Laure Kottler

    2011-10-01

    Full Text Available The precise role of estrogen in the pathogenesis of pelvic organ prolapse (POP is still unclear, while the results concerning the effect of selective estrogen receptor modulators on pelvic organ prolapse are contradictory. Our aim was to test whether alteration in the expression of estrogen receptors in the pelvic floor of preand post-menopausal women is related to genital prolapse status. The mRNA levels of ERα and ERβ in 60 biopsy specimens were measured. Significantly higher expression of ERα and higher ERα/ERβ ratio were demonstrated in post-menopausal women compared to pre-menopausal women. Higher expression of ERα and higher ERα/ERβ ratio were detected in all studied groups with POP, thus it did not reach significance in the post-menopausal group. Pre-menopausal and post-menopausal women presenting pelvic organ prolapse had no difference in the ERα expression. Our preliminary study may indicate that pelvic organ prolapse is associated with higher expression of ERα/ERβ in the pelvic floor of both pre- and post-menopausal women; thus not reaching statistical significance in the post-menopausal women was probably due to the group’s size. We believe that the inevitable changes in the estrogen receptor expression over women’s different lifetimes may affect the risk of genital prolapse progression, and might contribute to the further search for appropriate selective estrogen receptor modulators as a treatment for women with pelvic organ prolapse. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 3, pp. 521–527

  10. Impact of Estrogen Therapy on Lymphocyte Homeostasis and the Response to Seasonal Influenza Vaccine in Post-Menopausal Women.

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    Flora Engelmann

    Full Text Available It is widely recognized that changes in levels of ovarian steroids modulate severity of autoimmune disease and immune function in young adult women. These observations suggest that the loss of ovarian steroids associated with menopause could affect the age-related decline in immune function, known as immune senescence. Therefore, in this study, we determined the impact of menopause and estrogen therapy (ET on lymphocyte subset frequency as well as the immune response to seasonal influenza vaccine in three different groups: 1 young adult women (regular menstrual cycles, not on hormonal contraception; 2 post-menopausal (at least 2 years women who are not receiving any form of hormone therapy (HT and 3 post-menopausal hysterectomized women receiving ET. Although the numbers of circulating CD4 and CD20 B cells were reduced in the post-menopausal group receiving ET, we also detected a better preservation of naïve B cells, decreased CD4 T cell inflammatory cytokine production, and slightly lower circulating levels of the pro-inflammatory cytokine IL-6. Following vaccination, young adult women generated more robust antibody and T cell responses than both post-menopausal groups. Despite similar vaccine responses between the two post-menopausal groups, we observed a direct correlation between plasma 17β estradiol (E2 levels and fold increase in IgG titers within the ET group. These findings suggest that ET affects immune homeostasis and that higher plasma E2 levels may enhance humoral responses in post-menopausal women.

  11. Sexual dysfunction and the underlying medical problems in post-menopausal women

    Directory of Open Access Journals (Sweden)

    Soheila Nazarpour

    2016-02-01

    Full Text Available Background: Sexual dysfunction could be under the influence of some underlying medical problems. The purpose of this study is to examine the relationship between medical problems and sexual function in post-menopausal women. Methods: This is a community-based, descriptive-correlation study of 405 post-menopausal women residing in Chalus and Nowshahr cities, North of Iran, aged 40 to 65 years old from October 2013 to May 2014. A multistage, randomized sampling was conducted. The data was acquired through interviews using the Female Sexual Function Index (FSFI questionnaire and a researcher-made questionnaire, and was analyzed using descriptive and analytical tests such as multiple linear regression and logistic regression models. Results: 51.4% of the subjects had medical conditions. Cardiovascular disorders were the most common diseases among the subjects. 61% of the women were suffering from female sexual dysfunction (FSD. Sexual dysfunction in patients with medical conditions was significantly higher (P= 0.037. Scores of arousal (P= 0.000, orgasm (P= 0.018, and satisfaction (P= 0.026, as well as the FSFI total score (P= 0.005, were significantly lower in subjects with cardiovascular disorders. Scores of desire (P= 0.001, arousal (P= 0.006, lubrication (P= 0.010, orgasm (P= 0.004, and satisfaction (P= 0.022, as well as the FSFI total score (P= 0.017, were significantly lower in subjects with diabetes. Scores of pain were significantly lower in subjects with musculoskeletal disorders (P= 0.041, they experienced more pain during intercourse. In domains of arousal (P= 0.030, satisfaction (P= 0.040, and pain (P= 0.044, the scores of those taking antihypertensive medications were significantly lower than the scores of the rest of the subjects. Scores of desire (P= 0.001, arousal (P= 0.006, orgasm (P= 0.006, and satisfaction (P= 0.048, as well as the FSFI total score (P= 0.006, were significantly lower in those taking antidiabetic drugs. And lastly

  12. Comparison of myocardial function between post-menopausal and pre-menopausal women: evaluation by gated myocardial SPECT

    International Nuclear Information System (INIS)

    Hwang, K. H.; Choa, Won Sick; Yoon, Min Ki

    2005-01-01

    In addition to inhibiting coronary atherosclerosis, estrogen is expected to have protective effects on cardiac myocytes. We investigated the difference in myocardial functional parameters evaluated by gated myocardial SPECT after adenosine-stress between post-menopausal and pre-menopausal healthy women. This study included 22 healthy post-menopausal women (mean age: 53.0 yr) and 20 pre-menopausal women (mean age: 43.0 yr) who performed Tc-99m tetrofosmin gated myocardial SPECT after adenosine-stress. Measured hemodynamic parameters, EDV, ESV, stroke volume, EF, cardiac output and cardiac index were compared between the two groups. For comparison, similar-aged two male groups with matched numbers were also studied. There was no significant difference in hemodynamic parameters. EDV, ESV, stroke volume, EF, or cardiac output between the post-menopausal and pre-menopausal women. However, post-menopausal women have a smaller cardiac index (mean: 1.95 L/min/m2 vs 2.20 L/min/m2; p=0.045) and adenosine-induced HR increase (mean : 80.5/min vs 89.7/min ; p=0.03), compared to the pre-menopausal women. On the contrary, the two male groups of the same age range and numbers with the women groups showed no significant difference in any myocardial parameters. These results suggest that menopause may be correlated with reduced increase in cardiac index and HR increase after adenosine-stress

  13. Comparison of myocardial function between post-menopausal and pre-menopausal women: evaluation by gated myocardial SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, K. H.; Choa, Won Sick; Yoon, Min Ki [Gachon Medical School, Gil Hospital, Incheon (Korea, Republic of)

    2005-07-01

    In addition to inhibiting coronary atherosclerosis, estrogen is expected to have protective effects on cardiac myocytes. We investigated the difference in myocardial functional parameters evaluated by gated myocardial SPECT after adenosine-stress between post-menopausal and pre-menopausal healthy women. This study included 22 healthy post-menopausal women (mean age: 53.0 yr) and 20 pre-menopausal women (mean age: 43.0 yr) who performed Tc-99m tetrofosmin gated myocardial SPECT after adenosine-stress. Measured hemodynamic parameters, EDV, ESV, stroke volume, EF, cardiac output and cardiac index were compared between the two groups. For comparison, similar-aged two male groups with matched numbers were also studied. There was no significant difference in hemodynamic parameters. EDV, ESV, stroke volume, EF, or cardiac output between the post-menopausal and pre-menopausal women. However, post-menopausal women have a smaller cardiac index (mean: 1.95 L/min/m2 vs 2.20 L/min/m2; p=0.045) and adenosine-induced HR increase (mean : 80.5/min vs 89.7/min ; p=0.03), compared to the pre-menopausal women. On the contrary, the two male groups of the same age range and numbers with the women groups showed no significant difference in any myocardial parameters. These results suggest that menopause may be correlated with reduced increase in cardiac index and HR increase after adenosine-stress.

  14. Changes in serum somatomedin and growth hormone concentrations after 3 weeks oestrogen substitution in post-menopausal women; a pilot study

    NARCIS (Netherlands)

    Duursma, S. A.; Bijlsma, J. W.; van Paassen, H. C.; van Buul-Offers, S. C.; Skottner-Lundin, A.

    1984-01-01

    Oestrogens have a preventive effect on bone loss in post-menopausal women; however, little is known about their mechanism of action. The aim of this study was to investigate the changes in somatomedins (SM) and growth hormone (GH) concentrations in serum in post-menopausal women after 3 weeks of

  15. Effects of 17β-oestradiol and norethisterone acetate on sulfonation and sialylation of gonadotrophins in post-menopausal women

    Science.gov (United States)

    Naessén, Tord; Eriksson, Karin

    2010-01-01

    Background The number of terminal sialic acid and sulfonated N-acetylgalactosamine (SO3-GalNAc) on gonadotrophins in serum varies during the menstrual cycle and changes at menopause, suggesting that gonadal steroids modify their oligosaccharide synthesis. Our objective was to determine the effects of 17β-oestradiol (E2) and a progestogen, norethisterone acetate (NETA), on the sulfonation and sialylation of gonadotrophins in post-menopausal women. Methods Serum samples were obtained from eight post-menopausal women treated with 20 mg E2 implants every 6 months, from four women who in addition were treated daily with 5 mg NETA orally for a 2-week period, and from four women who got this NETA treatment during a 4-week period. Sera from 11 non-treated post-menopausal women served as a reference group. The gonadotrophin serum concentrations, the number of SO3-GalNAc and sialic acid residues per serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) molecule, and the distributions of molecules with 0-1-2-3-4 sulfonated residues were measured. Results The E2-treated post-menopausal women had considerably less (P sulfonation of LH (P sulfonation of LH and FSH. The primary effect of the NETA therapy was an increase in the sulfonation of LH and FSH concomitantly with secondary and consequentially decreases in sialylation of LH. PMID:20141368

  16. Effects of 17beta-oestradiol and norethisterone acetate on sulfonation and sialylation of gonadotrophins in post-menopausal women.

    Science.gov (United States)

    Wide, Leif; Naessén, Tord; Eriksson, Karin

    2010-05-01

    The number of terminal sialic acid and sulfonated N-acetylgalactosamine (SO(3)-GalNAc) on gonadotrophins in serum varies during the menstrual cycle and changes at menopause, suggesting that gonadal steroids modify their oligosaccharide synthesis. Our objective was to determine the effects of 17beta-oestradiol (E(2)) and a progestogen, norethisterone acetate (NETA), on the sulfonation and sialylation of gonadotrophins in post-menopausal women. Serum samples were obtained from eight post-menopausal women treated with 20 mg E(2) implants every 6 months, from four women who in addition were treated daily with 5 mg NETA orally for a 2-week period, and from four women who got this NETA treatment during a 4-week period. Sera from 11 non-treated post-menopausal women served as a reference group. The gonadotrophin serum concentrations, the number of SO(3)-GalNAc and sialic acid residues per serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) molecule, and the distributions of molecules with 0-1-2-3-4 sulfonated residues were measured. The E(2)-treated post-menopausal women had considerably less (P sulfonation of LH (P sulfonation of LH and FSH. The primary effect of the NETA therapy was an increase in the sulfonation of LH and FSH concomitantly with secondary and consequentially decreases in sialylation of LH.

  17. [Diagnostic accuracy of malignancy risk index II in post-menopausal women with adnexal tumours].

    Science.gov (United States)

    Treviño-Báez, Joaquín Darío; Cantú-Cruz, Javier Alejandro; Medina-Mercado, Javier; Abundis, Alberto

    2016-01-01

    The purpose of the diagnostic evaluation of adnexal tumours is to exclude the possibility of malignancy. The malignancy risk index II identifies patients at high risk for ovarian cancer. The cut-off value is greater than 200. To evaluate the diagnostic accuracy of malignancy risk index II in post-menopausal women with adnexal tumours in relation to the histopathological results. A total of 138 women with an adnexal mass were studied. The malignancy risk index II was determined in all of them. They were divided into two groups according to the histopathology results; 69 patients with benign tumours and 69 patients with malignant tumours. A diagnostic test type analysis was performed with respect to the results of malignancy risk index II ≤ 200 or greater than this. The percentages and 95% confidence intervals were calculated. The accuracy was 81.8% (75.5-88.3), sensitivity 76.8% (66.9-86.7), specificity 87% (79.1-94.9), with a positive predictive value of 85.5% (76.7-94.3), and a negative predictive value of 78.9% (69.7-88.1). The positive likelihood ratio was 590, and the negative likelihood ratio was 0.266. The malignancy risk index II has good performance in the proper classification of post-menopausal women with adnexal masses, both benign and malignant, with an accuracy of 81.8%. Copyright © 2015 Academia Mexicana de Cirugía A.C. Published by Masson Doyma México S.A. All rights reserved.

  18. Characteristics of post-menopausal women with genitourinary syndrome of menopause: Implications for vulvovaginal atrophy diagnosis and treatment selection.

    Science.gov (United States)

    Castelo-Branco, Camil; Biglia, Nicoletta; Nappi, Rossella E; Schwenkhagen, Anne; Palacios, Santiago

    2015-08-01

    Vulvovaginal atrophy (VVA), also known as genitourinary syndrome of menopause, exerts a negative impact on the sexuality, health and quality of life of post-menopausal women. A better understanding of post-menopausal women's profiles as defined by their attitude and behaviours in relation to their VVA symptoms may improve public health policies and will allow appropriate targeting of public health campaigns. These improvements may help women of middle and advanced age recover and maintain their quality of life. In this study, we analysed the attitudes of post-menopausal women, aged 45-74 years, with VVA symptoms from five European countries, with the aim of identifying profile markers to improve healthcare strategies. Two consecutive cross-sectional studies were conducted in five European countries (the UK, France, Spain, Germany and Italy). An initial exploratory study (n=69) was based on interviews and then an analytical study (n=749) was based on online surveys to validate women's profiles by means of a multi-level approach. We identified eight profiles: self-treater, pragmatic, vivacious, reserved, silent sufferer, expressive, stoic and sad. The percentage distribution varied among the countries. The 'pragmatic', 'vivacious' and 'expressive' women were the most proactive, talkative and open with their healthcare professional, whereas women with the 'reserved' and 'stoic' profiles showed less interest in searching for information about their VVA symptoms, either from their healthcare professional or from other sources. The attitudes and behaviours of post-menopausal women in relation to their VVA allow for the clear definition of a series of profiles with varying representation across countries. This study reveals the importance of identifying post-menopausal women's profiles to develop interventions to help them overcome barriers to the diagnosis, management and treatment of VVA. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  19. The effect of depressive symptomatology on plasma cortisol responses to acute bicycle exercise among post-menopausal women

    NARCIS (Netherlands)

    van der Pompe, G.; Bernards, N; Meijman, T.F.; Heijnen, C.J

    1999-01-01

    The present study was designed to elucidate the effect of depressive symptomatology on the cortisol response to strenuous exercise. Thirteen healthy, post-menopausal women participated in this study. The results show that acute bicycle exercise activates the hypothalamic-pituitary-adrenal (HPA) axis

  20. Metabolic alteration of urinary steroids in pre- and post-menopausal women, and men with papillary thyroid carcinoma

    Directory of Open Access Journals (Sweden)

    Chung Bong

    2011-08-01

    Full Text Available Abstract Background To evaluate the metabolic changes in urinary steroids in pre- and post-menopausal women and men with papillary thyroid carcinoma (PTC. Methods Quantitative steroid profiling combined with gas chromatography-mass spectrometry was used to measure the urinary concentrations of 84 steroids in both pre- (n = 21, age: 36.95 ± 7.19 yr and post-menopausal female (n = 19, age: 52.79 ± 7.66 yr, and male (n = 16, age: 41.88 ± 8.48 yr patients with PTC. After comparing the quantitative data of the patients with their corresponding controls (pre-menopause women: n = 24, age: 33.21 ± 10.48 yr, post-menopause women: n = 16, age: 49.67 ± 8.94 yr, male: n = 20, age: 42.75 ± 4.22 yr, the levels of steroids in the patients were normalized to the mean concentration of the controls to exclude gender and menopausal variations. Results Many urinary steroids were up-regulated in all PTC patients compared to the controls. Among them, the levels of three active androgens, androstenedione, androstenediol and 16α-hydroxy DHEA, were significantly higher in the pre-menopausal women and men with PTC. The corticoid levels were increased slightly in the PTC men, while progestins were not altered in the post-menopausal PTC women. Estrogens were up-regulated in all PTC patients but 2-hydroxyestrone and 2-hydroxy-17β-estradiol were remarkably changed in both pre-menopausal women and men with PTC. For both menopausal and gender differences, the 2-hydroxylation, 4-hydroxylation, 2-methoxylation, and 4-methoxylation of estrogens and 16α-hydroxylation of DHEA were differentiated between pre- and post-menopausal PTC women (P P -7. Conclusions These results are expected be helpful for better understanding the pathogenic differences in PTC according to gender and menopausal conditions.

  1. [Association between cardiovascular risk and lycopene consumption in pre- and post-menopausal women].

    Science.gov (United States)

    Torresani, María Elena

    2009-06-01

    This work aimed at assessing association between cardiovascular risk (CVR) and lycopene intake in pre- and post-menopausal women, as well as its correlation with LDL-C and HDL-C values and waist circumference (WC). A transversal design of comparison and correlation was carried out for independent samples. A 316 women (40-65 y) sample attending nutritional consultation at a Research Foundation for Endocrino Metabollic Diseases in Buenos Aires city (2005-2007) was randomized according to biological stage (35.8% premenopausal and 64.2% postmenopausal women). CVR was obtained based on Framingham Score and lycopene intake (source food and all lycopene containing food) according to weekly consumption frequency (mg/d and weekly/servings). Association between variables was calculated with the Student Test, Fisher Test and Pearson Correlation Coefficient (alpha significance level: 0.05). At both biological stages and for each CVR category, an inverse relationship was observed with lycopene intake, but only in premenopausal women with low CVR (Category III), lycopene intake was significantly greater than in those women who had moderate CVR (Category II). There was a significant correlation in postmenopausal women between LDL-C values and lycopene intake supplied by source food. However, in both biological stages a significant correlation was found between LDL-C values and all lycopene containing food consumption. No significant correlation was found between lycopene intake, HDL-C values and WC. These findings point out the relevances of a preventive nutritional approach at woman's different biological stages.

  2. Aromatase Inhibitors and the Risk of Colorectal Cancer in Post-Menopausal Women with Breast Cancer.

    Science.gov (United States)

    Khosrow-Khavar, F; Yin, H; Barkun, A; Bouganim, N; Azoulay, L

    2017-12-27

    A large trial of post-menopausal women with breast cancer reported an imbalance in colorectal cancer events with aromatase inhibitors (AIs), compared with tamoxifen in the adjuvant setting. This unexpected signal was observed within 3 years of randomization. To date, no observational studies have examined this important safety question in the natural setting of clinical practice. Thus, the objective of this study was to determine whether AIs, when compared with tamoxifen, are associated with increased risk of colorectal cancer in post-menopausal women with breast cancer. Using the United Kingdom Clinical Practice Research Datalink, we identified women, at least 55 years of age, with breast cancer newly-treated with either AIs or tamoxifen between January 1, 1996 and September 31, 2015, with follow-up until September 31, 2016. High-dimensional propensity score-adjusted Cox proportional hazards models were used to estimate hazard ratios (HRs) with 95% confidence intervals (CIs) of incident colorectal cancer associated with AIs when compared with tamoxifen overall, by cumulative duration of use, and time since initiation. All exposures were lagged by one year for latency considerations. A total of 9701 and 8893 patients initiated AIs and tamoxifen as first-line hormonal therapy (median follow-up of 2.4 and 2.9 years, respectively). Compared with tamoxifen, AIs were not associated with an increased risk of colorectal cancer (incidence rates of 150 per 100,000 person-years in both groups; adjusted HR: 0.90, 95% CI: 0.53-1.52). Similarly, there was no evidence of an association with cumulative duration of use (p-heterogeneity=0.54), and time since initiation (p-heterogeneity=0.66). In this first population-based study, the use of AIs was not associated with an increased risk of colorectal cancer. These findings should provide reassurance to the concerned stakeholders. © The Author 2017. Published by Oxford University Press on behalf of the European Society for Medical

  3. ENDOCRINE RESPONSE TO AN ULTRA-MARATHON IN PRE- AND POST-MENOPAUSAL WOMEN

    Directory of Open Access Journals (Sweden)

    J.L. Copeland

    2014-07-01

    Full Text Available Ultra-endurance competitions are becoming increasingly popular but there is limited research on female participants. The purpose of this study was to examine changes in estrogen and the IGF-I system in women after an ultra-marathon. Six pairs of pre- and post- menopausal women were matched for race finish times;mean finish time was 20 hours. Blood samples were drawn 24 hours before the race, at the finish, and 24 hours into recovery. Samples were analysed for estradiol, total IGF-I, IGFBP-1, and intact IGFBP-3. There was a significant increase in estradiol following the race in both groups (P<0.05. Total IGF-I decreased after the race (P<0.01 and remained lower in recovery. IGFBP-1 increased after the race (P<0.001 but returned to pre-race levels after 24 hours, while intact IGFBP-3 was significantly lower post-race and in recovery (P<0.001. Postmenopausal women had significantly lower estradiol at baseline, but there were no other group differences. These results demonstrate that among recreational female runners, an ultra-marathon is associated with IGF system changes that are consistent with an energy-deficient, catabolic state. Further research is needed to confirm the effect of these endocrine changes on health and performance

  4. Effect of osteoporosis on periodontal therapy among post-menopausal women.

    Science.gov (United States)

    Gomes-Filho, Isaac S; Oliveira, Tiago J S; Passos, Johelle S; Cerqueira, Eneida de M M; da Cruz, Simone S; Barreto, Maurício L; Coelho, Julita M F; Trindade, Soraya C; Santos, Carlos A S T; Sarmento, Viviane A

    2013-03-01

    This intervention study aimed to investigate the effect of osteoporosis on periodontal condition among 48 post-menopausal women undergoing periodontal therapy. The experimental group, which underwent non-surgical periodontal therapy, was composed of 16 women with periodontitis to be treated, and the control group was formed by 32 women without periodontitis. Oral condition was assessed on three occasions: at the start of the treatment (first examination), 1 month (first re-examination) and 4 months after the end of the therapy (second re-examination). In the second re-examination, recurrence of periodontal disease was evaluated by comparing the clinical measurements obtained pre- and post-treatment. The diagnosis of osteoporosis was made by investigating densitometry reports obtained previously. Descriptive analysis, analysis of variance and the Bonferroni post hoc test were applied to the data gathered, with statistical significance level of 5%. The frequency of periodontitis was 50% in the treated group and 25% in the group without periodontitis. In both groups, this recurrence was greater in subjects with osteoporosis (37.5 and 18.75%, respectively) than in the individuals without osteoporosis (12.5 and 6.25%, respectively). The preliminary results indicate that osteoporosis possibly has an influence on periodontal condition among individuals undergoing non-surgical periodontal treatment. © 2012 The Gerodontology Society and John Wiley & Sons A/S.

  5. Association of LRP5 genotypes with osteoporosis in Tunisian post-menopausal women.

    Science.gov (United States)

    Sassi, Rim; Sahli, Hela; Souissi, Chiraz; El Mahmoudi, Hejer; Zouari, Bechir; Ben Ammar ElGaaied, Amel; Sellami, Slaheddine; Ferrari, Serge Livio

    2014-04-30

    Osteoporosis is a highly heritable trait. Among the genes associated with bone mineral density (BMD), the low-density lipoprotein receptor-related protein 5 gene (LRP5) has been consistently identified in Caucasians. However LRP5 contribution to osteoporosis in populations of other ethnicities remains poorly known. To determine whether LRP5 polymorphisms Ala1330Val and Val667Met are associated with BMD in North Africans, these genotypes were analyzed in 566 post-menopausal Tunisian women with mean age of 59.5 ± 7 .7 years, of which 59.1% have low bone mass (T-scoreosteoporosis than in women with normal BMD (p=0.066). Adjusting for body size and other potential confounders, LRP5 genotypes were no longer significantly associated with aBMD at any site. The less common Val667Met polymorphism showed no association with osteoporosis. The Ala1330Val polymorphism is weakly associated with lower lumbar spine bone density and osteopenia/osteoporosis in postmenopausal Tunisian women. These observations expand our knowledge about the contribution of LRP5 genetic variation to osteoporosis risk in populations of diverse ethnic origin.

  6. Phenolic metabolites of anthocyanins following a dietary intervention study in post-menopausal women.

    Science.gov (United States)

    de Ferrars, Rachel M; Cassidy, Aedín; Curtis, Peter; Kay, Colin D

    2014-03-01

    Numerous studies feeding anthocyanin-rich foods report limited bioavailability of the parent anthocyanins. The present study explores the identity and concentration of the phenolic metabolites of anthocyanins in humans. Anthocyanin metabolites were quantified in samples collected from a previously conducted 12-wk elderberry intervention study in healthy post-menopausal women. Individual 1-, 2- and 3-h post-bolus urine samples and pooled plasma samples following acute (single bolus) and chronic (12-wk supplementation) anthocyanin consumption (500 mg/day) were analysed using HPLC-ESI-MS/MS. Twenty-eight anthocyanin metabolites were identified in urine and 21 in plasma (including sulfates of vanillic, protocatechuic and benzoic acid). Phenolic metabolites reached peak concentrations of 1237 nM in plasma, while anthocyanin conjugates only reached concentrations of 34 nM. Similarly, in urine, phenolic metabolites were detected at concentrations of 33,185 ± 2549 nM/mM creatinine, while anthocyanin conjugates reached concentrations of 548 ± 219 nM/mM creatinine. There was no evidence that chronic exposure had any impact on either the profile or quantity of metabolites recovered relative to acute exposure. An extensive range of phenolic metabolites of anthocyanin was identified following elderberry consumption in humans, including 11 novel metabolites, which were identified at much higher concentrations than their parent compounds. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. Determinants of plasma alkylresorcinol concentration in Danish post-menopausal women.

    Science.gov (United States)

    Landberg, R; Kamal-Eldin, A; Aman, P; Christensen, J; Overvad, K; Tjønneland, A; Olsen, A

    2011-01-01

    Alkylresorcinols (AR), a group of phenolic lipids present in the outer parts of wheat and rye grain kernels, have been suggested as biomarkers of whole-grain wheat and rye intake. In this study, we investigated potential determinants of plasma AR concentration in a free-living population. Non-fasting samples from post-menopausal women enrolled in the Danish Diet, Cancer and Health study (n = 360) were selected. Diet was assessed using a semi-quantitative food frequency questionnaires (FFQ) and the association between food items likely to contain AR and relevant non-dietary factors were studied by analysis of covariance models. The median AR concentration was 78 nmol/l (interquartile range = 106.9 nmol/l). Intake of rye bread, identified as the main determinant, was associated with 87% higher plasma total AR concentration per 100 g of bread (95% confidence interval = 46-139%). About 8-12% of the total variation (depending on the AR homologue) in plasma AR concentration was explained by the selected dietary variables. At a nutrient level, total dietary fiber and cereal fiber were significantly associated with plasma total AR concentration (P = 0.05), but only ≈2% of the total plasma AR concentration was explained by the dietary fiber or cereal fiber intake. In the studied population, AR plasma concentration was mainly affected by rye bread intake among investigated determinants.

  8. Mammographic parenchymal texture as an imaging marker of hormonal activity: a comparative study between pre- and post-menopausal women

    Science.gov (United States)

    Daye, Dania; Bobo, Ezra; Baumann, Bethany; Ioannou, Antonios; Conant, Emily F.; Maidment, Andrew D. A.; Kontos, Despina

    2011-03-01

    Mammographic parenchymal texture patterns have been shown to be related to breast cancer risk. Yet, little is known about the biological basis underlying this association. Here, we investigate the potential of mammographic parenchymal texture patterns as an inherent phenotypic imaging marker of endogenous hormonal exposure of the breast tissue. Digital mammographic (DM) images in the cranio-caudal (CC) view of the unaffected breast from 138 women diagnosed with unilateral breast cancer were retrospectively analyzed. Menopause status was used as a surrogate marker of endogenous hormonal activity. Retroareolar 2.5cm2 ROIs were segmented from the post-processed DM images using an automated algorithm. Parenchymal texture features of skewness, coarseness, contrast, energy, homogeneity, grey-level spatial correlation, and fractal dimension were computed. Receiver operating characteristic (ROC) curve analysis was performed to evaluate feature classification performance in distinguishing between 72 pre- and 66 post-menopausal women. Logistic regression was performed to assess the independent effect of each texture feature in predicting menopause status. ROC analysis showed that texture features have inherent capacity to distinguish between pre- and post-menopausal statuses (AUC>0.5, pcontraception use and hormonal replacement therapy (HRT) use lead to a modest model improvement (AUC=0.78) while texture features maintained significant contribution (p<0.05). The observed differences in parenchymal texture features between pre- and post- menopausal women suggest that mammographic texture can potentially serve as a surrogate imaging marker of endogenous hormonal activity.

  9. Diagnostic efficacy of panoramic radiography in detection of osteoporosis in post-menopausal women with low bone mineral density.

    Science.gov (United States)

    Bhatnagar, Sunanda; Krishnamurthy, Vasavi; Pagare, Sandeep S

    2013-01-01

    The aim of the study was to evaluate panoramic radiograph, a commonly taken dental radiograph as a screening tool to detect early osseous changes (normal, mildly or severely eroded) of the mandibular inferior cortex and measure the mandibular cortical width (CW) in post-menopausal women and correlate it with the bone mineral density (BMD) measured by the ultrasound bone sonometer at the mid-shaft tibia region. The study included females between 45 years and 65 years of age in their post-menopausal stage (no menstruation for at least 6-12 months). Mandibular indices (mandibular CW and mandibular cortical shape) were evaluated from panoramic radiographs. The BMD assessment was carried out at the mid-shaft tibia region, exactly half-way between the heel and the knee joint perpendicular to the direction of the bone, using an ultrasound bone sonometer. It is a non-invasive device designed for quantitative measurement of the velocity of ultrasound waves as speed of sound in m/s, capable of measuring bone density at one or more skeletal sites. Using 1994 WHO criteria the study subjects were categorized as Group 1: Normal, Group 2: Osteopenia, Group 3: Osteoporosis. (WHO T score for tibia BMD can be used as a standard). The diagnostic efficacy of the panoramic radiograph in detecting osseous changes in post-menopausal women with low BMD was shown to have 96% specificity and 60% sensitivity with mandibular cortical shape and 58% specificity and 73% sensitivity with mandibular CW measurement. Factorial ANOVA analysis carried out indicated a significant correlation of BMD classification with mandibular cortical shape (F = 29.0, P panoramic radiograph are effective indicators of osteoporosis in post-menopausal women.

  10. Metabolic alteration of urinary steroids in pre- and post-menopausal women, and men with papillary thyroid carcinoma

    International Nuclear Information System (INIS)

    Choi, Man Ho; Moon, Ju-Yeon; Cho, Sung-Hee; Chung, Bong Chul; Lee, Eun Jig

    2011-01-01

    To evaluate the metabolic changes in urinary steroids in pre- and post-menopausal women and men with papillary thyroid carcinoma (PTC). Quantitative steroid profiling combined with gas chromatography-mass spectrometry was used to measure the urinary concentrations of 84 steroids in both pre- (n = 21, age: 36.95 ± 7.19 yr) and post-menopausal female (n = 19, age: 52.79 ± 7.66 yr), and male (n = 16, age: 41.88 ± 8.48 yr) patients with PTC. After comparing the quantitative data of the patients with their corresponding controls (pre-menopause women: n = 24, age: 33.21 ± 10.48 yr, post-menopause women: n = 16, age: 49.67 ± 8.94 yr, male: n = 20, age: 42.75 ± 4.22 yr), the levels of steroids in the patients were normalized to the mean concentration of the controls to exclude gender and menopausal variations. Many urinary steroids were up-regulated in all PTC patients compared to the controls. Among them, the levels of three active androgens, androstenedione, androstenediol and 16α-hydroxy DHEA, were significantly higher in the pre-menopausal women and men with PTC. The corticoid levels were increased slightly in the PTC men, while progestins were not altered in the post-menopausal PTC women. Estrogens were up-regulated in all PTC patients but 2-hydroxyestrone and 2-hydroxy-17β-estradiol were remarkably changed in both pre-menopausal women and men with PTC. For both menopausal and gender differences, the 2-hydroxylation, 4-hydroxylation, 2-methoxylation, and 4-methoxylation of estrogens and 16α-hydroxylation of DHEA were differentiated between pre- and post-menopausal PTC women (P < 0.001). In particular, the metabolic ratio of 2-hydroxyestrone to 2-hydroxy-17β-estradiol, which could reveal the enzyme activity of 17β-hydroxysteroid dehydrogenase, showed gender differences in PTC patients (P < 1 × 10 -7 ). These results are expected be helpful for better understanding the pathogenic differences in PTC according to gender and menopausal conditions

  11. Real-world effectiveness of osteoporosis therapies for fracture reduction in post-menopausal women.

    Science.gov (United States)

    Yusuf, Akeem A; Cummings, Steven R; Watts, Nelson B; Feudjo, Maurille Tepie; Sprafka, J Michael; Zhou, Jincheng; Guo, Haifeng; Balasubramanian, Akhila; Cooper, Cyrus

    2018-03-21

    Studies examining real-world effectiveness of osteoporosis therapies are beset by limitations due to confounding by indication. By evaluating longitudinal changes in fracture incidence, we demonstrated that osteoporosis therapies are effective in reducing fracture risk in real-world practice settings. Osteoporosis therapies have been shown to reduce incidence of vertebral and non-vertebral fractures in placebo-controlled randomized clinical trials. However, information on the real-world effectiveness of these therapies is limited. We examined fracture risk reduction in older, post-menopausal women treated with osteoporosis therapies. Using Medicare claims, we identified 1,278,296 women age ≥ 65 years treated with zoledronic acid, oral bisphosphonates, denosumab, teriparatide, or raloxifene. Fracture incidence rates before and after treatment initiation were described to understand patients' fracture risk profile, and fracture reduction effectiveness of each therapy was evaluated as a longitudinal change in incidence rates. Fracture incidence rates increased during the period leading up to treatment initiation and were highest in the 3-month period most proximal to treatment initiation. Fracture incidence rates following treatment initiation were significantly lower than before treatment initiation. Compared with the 12-month pre-index period, there were reductions in clinical vertebral fractures for denosumab (45%; 95% confidence interval [CI] 39-51%), zoledronic acid (50%; 95% CI 47-52%), oral bisphosphonates (24%; 95% CI 22-26%), and teriparatide (72%; 95% CI 69-75%) during the subsequent 12 months. Relative to the first 3 months after initiation, clinical vertebral fractures were reduced for denosumab (51%; 95% CI 42-59%), zoledronic acid (25%; 95% CI 17-32%), oral bisphosphonates (23%; 95% CI 20-26%), and teriparatide (64%; 95% CI 58-69%) during the subsequent 12 months. In summary, reductions in fracture incidence over time were observed in cohorts

  12. Enhanced HIV-1 replication in ex vivo ectocervical tissues from post-menopausal women correlates with increased inflammatory responses.

    Science.gov (United States)

    Rollenhagen, C; Asin, S N

    2011-11-01

    Knowledge about early innate immune responses at the mucosal surfaces of the female genital tract is important in understanding the pathogenesis of heterosexual transmission of human immunodeficiency virus type-1 (HIV-1). As estradiol decreases inflammatory responses, we postulated that an estradiol-deficient state such as post-menopause could enhance expression of inflammatory factors that stimulate HIV-1 replication. We compare HIV-1 integration, transcription, and viral p24 release levels among ectocervical tissues obtained from pre- and post-menopausal donors. We detected enhanced HIV-1 p24 release levels in post- compared with pre-menopausal tissues (Ppost-menopausal tissues exhibited levels of HIV-1 transcription above background compared with only 60% of pre-menopausal tissues. Increased HIV-1 transcription was associated with enhanced interleukin (IL)-1β, IL-6, monocyte chemotactic protein-1, growth-regulated oncogene-α, and interferon-γ-inducible protein-10 expression. Neutralization and nuclear factor-κB-targeting small-interfering RNA experiments both decreased HIV-1 transcription, suggesting that the early inflammatory response may facilitate HIV-1 replication in ex vivo ectocervical tissues from post-menopausal women.

  13. Pyometra presenting in conjunction with bowel cancer in a post-menopausal women: a case report.

    Science.gov (United States)

    Soleymani Majd, Hooman; Watermeyer, Sean; Ismail, Lamiese

    2008-07-08

    This case describes a 71 year old, post-menopausal woman who developed vaginal discharge. This complaint ultimately led to the discovery of bowel cancer in conjunction with a large sterile pyometra.The pyometra was not due to genital malignancy. The most likely conclusion is that the pyometra may have arisen as an inflammatory response to the adjacent bowel pathology. This case report highlights the need for clinicians to consider non-gynaecological cancer as a possible cause for otherwise unexplained pyometra.

  14. Pyometra presenting in conjunction with bowel cancer in a post-menopausal women: a case report

    OpenAIRE

    Soleymani majd, Hooman; Watermeyer, Sean; Ismail, Lamiese

    2008-01-01

    This case describes a 71 year old, post-menopausal woman who developed vaginal discharge. This complaint ultimately led to the discovery of bowel cancer in conjunction with a large sterile pyometra. The pyometra was not due to genital malignancy. The most likely conclusion is that the pyometra may have arisen as an inflammatory response to the adjacent bowel pathology. This case report highlights the need for clinicians to consider non-gynaecological cancer as a possible cause for otherwise u...

  15. Diagnostic Efficacy of Panoramic Radiography in Detection of Osteoporosis in Post-Menopausal Women with Low Bone Mineral Density

    Directory of Open Access Journals (Sweden)

    Sunanda Bhatnagar

    2013-01-01

    Full Text Available Objective: The aim of the study was to evaluate panoramic radiograph, a commonly taken dental radiograph as a screening tool to detect early osseous changes (normal, mildly or severely eroded of the mandibular inferior cortex and measure the mandibular cortical width (CW in post-menopausal women and correlate it with the bone mineral density (BMD measured by the ultrasound bone sonometer at the mid-shaft tibia region. Materials and Methods: The study included females between 45 years and 65 years of age in their post-menopausal stage (no menstruation for at least 6-12 months. Mandibular indices (mandibular CW and mandibular cortical shape were evaluated from panoramic radiographs. The BMD assessment was carried out at the mid-shaft tibia region, exactly half-way between the heel and the knee joint perpendicular to the direction of the bone, using an ultrasound bone sonometer. It is a non-invasive device designed for quantitative measurement of the velocity of ultrasound waves as "speed of sound" in m/s, capable of measuring bone density at one or more skeletal sites. Using 1994 WHO criteria the study subjects were categorized as Group 1: Normal, Group 2: Osteopenia, Group 3: Osteoporosis. (WHO T score for tibia BMD can be used as a standard. Results: The diagnostic efficacy of the panoramic radiograph in detecting osseous changes in post-menopausal women with low BMD was shown to have 96% specificity and 60% sensitivity with mandibular cortical shape and 58% specificity and 73% sensitivity with mandibular CW measurement. Factorial ANOVA analysis carried out indicated a significant correlation of BMD classification with mandibular cortical shape (F = 29.0, P < 0.001, partial eta squared [η2 ] =0.85, a non-significant correlation with mandibular CW, (F = 1.6, P = 0.23, η2 = 0.86, and a more significant correlation with combined cortical shape and width (F = 3.3, P < 0.05, η2 = 0.70. Conclusion: The study concludes that the combined mandibular

  16. Increased Intake of Selected Vegetables, Herbs and Fruit may Reduce Bone Turnover in Post-Menopausal Women

    Directory of Open Access Journals (Sweden)

    Caroline Ann Gunn

    2015-04-01

    Full Text Available Increased consumption of vegetables/herbs/fruit may reduce bone turnover and urinary calcium loss in post-menopausal women because of increased intake of polyphenols and potassium, but comparative human studies are lacking. The main aim was to compare bone turnover markers and urinary calcium excretion in two randomised groups (n = 50 of healthy post-menopausal women consuming ≥9 servings of different vegetables/herbs/fruit combinations (three months. Group A emphasised a generic range of vegetables/herbs/fruit, whereas Group B emphasised specific vegetables/herbs/fruit with bone resorption-inhibiting properties (Scarborough Fair Diet, with both diets controlled for potential renal acid load (PRAL. Group C consumed their usual diet. Plasma bone markers, urinary electrolytes (24 h and estimated dietary PRAL were assessed at baseline and 12 weeks. Procollagen type I N propeptide (PINP decreased (−3.2 μg/L, p < 0.01 in the B group only, as did C-terminal telopeptide of type I collagen (CTX (−0.065 μg/L, p < 0.01 in women with osteopenia compared to those with normal bone mineral density (BMD within this group. Intervention Groups A and B had decreased PRAL, increased urine pH and significantly decreased urinary calcium loss. Urinary potassium increased in all groups, reflecting a dietary change. In conclusion, Group B demonstrated positive changes in both turnover markers and calcium conservation.

  17. Association between Soy Isoflavone Intake and Breast Cancer Risk for Pre- and Post-Menopausal Women: A Meta-Analysis of Epidemiological Studies

    Science.gov (United States)

    Zheng, Yi; Wei, Shiqing; Li, Ye; Guo, Tong; Yin, Ping

    2014-01-01

    Background Conclusions drawn from meta-analyses on the association between soy isoflavone intake and breast cancer risk for pre- and post-menopausal women are not fully consistent. These meta-analyses did not explore the influence of different study designs on the pooled results on the basis of distinguishing between pre- and post-menopausal women. Methodology and Principal Findings We performed a meta-analysis of 35 studies which reported results of association between soy isoflavone intake and breast cancer risk for pre- and/or post-menopausal women, calculated pooled odds ratios and their 95% confidence intervals of pre- and post-menopausal women respectively, and further explored soy isoflavone-breast cancer association on the basis of considering different study regions and designs. Summary results suggested that soy isoflavone intake has a protective effect against breast cancer for both pre- and post-menopausal women. However, they are influenced by study design and region. Pooled ORs of studies carried out in Asian countries suggested that soy isoflavone’s protective effect exist in both pre- and post-menopausal women (OR = 0.59, 95%CI: 0.48–0.69 for premenopausal women; OR = 0.59, 95%CI: 0.44–0.74 for postmenopausal women). However, there are some differences between the results pooled from different study designs for women in Asian countries (test for consistency, P = 0.04). Pooled OR of studies on postmenopausal women in Western countries suggested that soy isoflavone intake has a marginally significant protective effect (OR = 0.92; 95%CI: 0.83∼1.00), but further analyses stratifying by study design found no statistically significant association. Conclusions We meta-analyzed more and newer research results, and separated women according to menopausal status to explore soy isoflavone-breast cancer association. We founded that soy isoflavone intake could lower the risk of breast cancer for both pre- and post-menopausal women in

  18. The theory of modulated hormone therapy for the treatment of breast cancer in pre- and post-menopausal women

    Science.gov (United States)

    Wiley, Teresa S.; Haraldsen, Jason T.

    2012-03-01

    We present a theory that questions the standard of care for pre- and post-menopausal women with breast cancer. Through the use of modulated hormones to mimic the natural multiphasic fluctuations of estrogen and progesterone cycles of healthy young women, it can be expected that patients will not only exhibit increased quality of life such as better sleep, well-being, and libido, but also memory improvement and less joint pain. Additionally, this regimen may engage genetic pathways that protect women in youth from breast cancers. We present a mathematical basis for the coupling of the hormone cycles through the use of Gaussian curves that provides the foundation of a new format of hormone replacement in women.

  19. The theory of modulated hormone therapy for the treatment of breast cancer in pre- and post-menopausal women

    Directory of Open Access Journals (Sweden)

    Teresa S. Wiley

    2012-03-01

    Full Text Available We present a theory that questions the standard of care for pre- and post-menopausal women with breast cancer. Through the use of modulated hormones to mimic the natural multiphasic fluctuations of estrogen and progesterone cycles of healthy young women, it can be expected that patients will not only exhibit increased quality of life such as better sleep, well-being, and libido, but also memory improvement and less joint pain. Additionally, this regimen may engage genetic pathways that protect women in youth from breast cancers. We present a mathematical basis for the coupling of the hormone cycles through the use of Gaussian curves that provides the foundation of a new format of hormone replacement in women.

  20. Pyometra in elderly post-menopausal women: a sign of malignity.

    Science.gov (United States)

    Kerimoglu, O S; Pekin, A; Yilmaz, S A; Bakbak, B B Gençoğlu; Celik, C

    2015-01-01

    To describe the clinical and histopathological characteristics of 12 patients with pyometra and highlight the increased incidence of gynecological malignancy in these patients. The authors examined the medical records of 12 patients with pyometra, who were treated between 2009 and 2013. All patients were post-menopausal, and their mean age was 70.83 ± 6.978 years (min = 61, max = 82). To remove purulent fluid via dilation and because of the probability of malignancy, three patients (25%) underwent cervical biopsy and endometrial curettage; the other nine patients (75%) underwent curettage alone, with suitable antibiotic therapy. Of the 12 patients, nine (75%) had gynecologic malignancy [(endometrial cancer, n = 5, 41.6%), (cervical cancer, n = 3, 25%), (uterine leiomyosarcoma, n = 1, 8.3%)]. In three (25%) patients, the cause of pyometra was benign pathologies, among which the most common were leiomyomas (n = 2, 66.6%). Pyometra diagnosed during the post-menopausal period should be considered a complication caused by gynecological malignancy until proven otherwise.

  1. [β-estradiol activates BK(Ca) in mesenteric artery smooth muscle cells of post-menopause women].

    Science.gov (United States)

    Cheng, Jun; Zeng, Xiao-Rong; Li, Peng-Yun; Lu, Ting-Ting; Tan, Xiao-Qiu; Wen, Jing; Yang, Yan

    2012-04-25

    The aim of the present study was to study the effect of β-estradiol (β-E(2)) on the large-conductance Ca(2+)-activated potassium (BK(Ca)) channel in mesenteric artery smooth muscle cells (SMCs). The mesenteric arteries were obtained from post-menopause female patients with abdominal surgery, and the SMCs were isolated from the arteries using an enzymatic disassociation. According to the sources, the SMCs were divided into non-hypertension (NH) and essential hypertension (EH) groups. Single channel patch clamp technique was used to investigate the effect of β-E(2) and ICI 182780 (a specific blocker of estrogen receptor) on BK(Ca) in the SMCs. The results showed the opening of BK(Ca) in the SMCs was voltage and calcium dependent, and could be blocked by IbTX. β-E(2) (100 μmol/L) significantly increased open probability (Po) of BK(Ca) in both NH and EH groups. After β-E(2) treatment, NH group showed higher Po of BK(Ca) compared with EH group. ICI 182780 could inhibit the activating effect of β-E(2) on BK(Ca) in no matter NH or EH groups. These results suggest β-E(2) activates BK(Ca) in mesenteric artery SMCs from post-menopause women via estrogen receptor, but hypertension may decline the activating effect of β-E(2) on BK(Ca).

  2. Study on the relationship between serum testosterone level and forearm distal bone density in post-menopausal women

    International Nuclear Information System (INIS)

    Li Wenqi; Zhou Zhengli; Li Xin; Zhou Jiwen

    2002-01-01

    Objective: To study the relationship between the androgen level and bone density in post-menopausal women. Methods: Serum testosterone (T) level and forearm distal bone density (BMD) were measured in 39 past-menopausal women who had never taken any estrogen or calcium preparation. Their serum estradiol (E 2 ) levels were about the same. According to their BMD, the 39 subjects were divided into normal (n = 22) and osteoporotic (n = 17) groups. Results: The mean serum testosterone (T) level in the normal group was significantly higher than that in the osteoporotic group (p 1 = 0.72, r 2 0.75; p 1 and r 2 was 0.14, suggesting similarity of the positive cor-relationship for both groups (p > 0.05). Conclusion: Serum testosterone level seems to bear close relationship with bone density and osteoporosis

  3. Misoprostol prior to hysteroscopy in premenopausal and post-menopausal women. A systematic review and meta-analysis.

    Science.gov (United States)

    Polyzos, N P; Zavos, A; Valachis, A; Dragamestianos, C; Blockeel, C; Stoop, D; Papanikolaou, E G; Tournaye, H; Devroey, P; Messinis, I E

    2012-07-01

    Although several randomized controlled trials (RCTs) have examined the effect of misoprostol prior to hysteroscopy for cervical dilatation, no solid conclusion has been reached. We therefore set out to perform a meta-analysis of RCTs. We searched MEDLINE, the ISI Web of Science and the Cochrane Library to identify RCTs comparing misoprostol versus placebo or control prior to hysteroscopy. No restrictions on language or time were applied. Relative risks (RRs) and 95% confidence intervals (CIs) were calculated for all dichotomous outcomes, whereas mean differences (MDs) and 95% CIs were calculated for continuous outcomes using the Mantel-Haenszel or DerSimonian-Laird model according to the heterogeneity. Of the initial 141 potentially relevant articles that were retrieved, 21 RCTs involving 1786 patients were included in the meta-analysis. Subgroup analyses were performed according to menopausal status and according to whether diagnostic or operative hysteroscopy was performed. Premenopausal women treated with misoprostol had a significantly lower risk for further cervical dilatation in the diagnostic setting [RR (95% CI): 0.56 (0.34-0.92)] and a significantly lower risk for cervical laceration in the operative setting [RR (95% CI): 0.22 (0.09-0.54)], compared with placebo. In contrast, post-menopausal patients did not experience any clear benefit from misoprostol compared with placebo regarding the need for further cervical dilatation [RR (95% CI): 0.99 (0.76-1.30)] and the cervical laceration rate [RR (95% CI): 1.15 (0.40-3.29)]. In addition, the mean cervical width prior to hysteroscopy was significantly higher in premenopausal women treated with misoprostol compared with placebo [MD (95% CI): 2.47 mm (1.81-3.13)] but did not differ among post-menopausal patients [MD (95% CI): 0.39 mm (-0.42 to 1.21)]. Misoprostol prior to hysteroscopy appears to facilitate an easier and uncomplicated procedure only in premenopausal women.

  4. The relative efficacy of nine osteoporosis medications for reducing the rate of fractures in post-menopausal women

    Directory of Open Access Journals (Sweden)

    Pullenayegum Eleanor

    2011-09-01

    Full Text Available Abstract Background In the absence of head-to-head trials, indirect comparisons of randomized placebo-controlled trials may provide a viable option to assess relative efficacy. The purpose was to estimate the relative efficacy of reduction of fractures in post-menopausal women, and to assess robustness of the results. Methods A systematic literature review of multiple databases identified randomized placebo-controlled trials with nine drugs for post-menopausal women. Odds ratio and 95% credibility intervals for the rates of hip, non-vertebral, vertebral, and wrist fractures for each drug and between drugs were derived using a Bayesian approach. A drug was ranked as the most efficacious if it had the highest posterior odds ratio, or had the highest effect size. Results 30 studies including 59,209 patients reported fracture rates for nine drugs: alendronate (6 studies, denosumab (1 study, etidronate (8 studies, ibandronate (4 studies, raloxifene (1 study, risedronate (7 studies, strontium (2 study, teriparatide (1 study, and zoledronic acid (1 study. The drugs with the highest probability of reducing non-vertebral fractures was etidronate and teriparatide while the drugs with the highest probability of reducing vertebral, hip or wrist fractures were teriparatide, zoledronic acid and denosumab. The drugs with the largest effect size for vertebral fractures were zoledronic acid, teriparatide and denosumab, while the drugs with the highest effect size for non-vertebral, hip or wrist fractures were alendronate or risedronate. Estimates were consistent between Bayesian and classical approaches. Conclusion Teriparatide, zoledronic acid and denosumab have the highest probabilities of being most efficacious for non-vertebral and vertebral fractures, and having the greatest effect sizes. The estimates from indirect comparisons were robust to differences in methodology.

  5. Breast size, thoracic kyphosis & thoracic spine pain - association & relevance of bra fitting in post-menopausal women: a correlational study.

    Science.gov (United States)

    Spencer, Linda; Briffa, Kathy

    2013-07-01

    Menopause would seem to exist as a period of accelerated changes for women and their upper torso mechanics. Whether these anthropometric changes reflect changes in pain states remains unclear. Plausible mechanisms of pain exist for the independent and combined effect of increasing breast size and thoracic kyphosis. Bra fit has the potential to change when the anthropometric measures (chest circumference and bust circumference) used to determine bra size change, such as postmenopausally.Identifying an association between breast size, thoracic kyphosis and thoracic spine pain in postmenopausal women and identifying the relevance of bra fit to this association may be of importance to the future management and education of post-menopausal women presenting clinically with thoracic spine pain. A cross-sectional study design. Fifty-one postmenopausal bra-wearing women were recruited. Measures included breast size (Triumph International), thoracic kyphosis (flexible curve), bra fitted (Y/N) and pain (Short Form McGill Pain Questionnaire) and tenderness on palpation (posteroanterior pressure testing). These measures were collected in one session at a physiotherapy clinic. The majority of the women in this study were overweight or obese and wearing an incorrect sized bra. Pain was significantly related to breast size, body weight and BMI at mid thoracic levels (T7-8). In contrast self-reported thoracic pain was not correlated with age or index of kyphosis (thoracic kyphosis). Women with thoracic pain were no more likely to have their bra professionally fitted whereas women with a higher BMI and larger breasts were more likely to have their bra professionally fitted. The findings of this study show that larger breasts and increased BMI are associated with thoracic pain in postmenopausal women. This is unrelated to thoracic kyphosis. Increasing breast size and how a bra is worn may have biomechanical implications for the loaded thoracic spine and surrounding musculature. Post-menopause

  6. Whole body retention of Tc-99m Methylene Diphosphonate (MDP) in monitoring skeletal calcium status in post-menopausal women

    International Nuclear Information System (INIS)

    Patel, R.B.; Rangarajan, V.; Samuel, A.M.; Joshi, D.P.; Ray, S.; Raste, A.S.; Gadhre

    2003-01-01

    The detection and estimation of skeletal calcium loss has become an important consideration in the management of post-menopausal women. The need to supplement large amounts of calcium of 1000-1500 mg per day is recommended to forestall the risk of skeletal fractures. The added supplementation of estrogens and progesterone for several years is also recommended to prevent bone calcium loss. The need to record the calcium status in post-menopausal women is becoming necessary in the present scenario. A total of 159 women in the peri-menopausal, menopausal and post-menopausal groups were selected. None of them had other systemic diseases. They were healthy and not on any medication. They were randomly grouped into 3 groups. One was considered as control and no medication was advised. The second group was advised 1000-1500 mg of calcium carbonate daily. The third group was given the same dose of calcium, but also received additionally another 2 mg of estradiol daily. Whole Body Retention (WBR) studies of Tc-99m MDP were carried out before starting treatment and at 6 monthly intervals for a period of 5 years. Serum calcium and alkaline phosphatase were estimated on fasting samples at the start of the study and at every 6 monthly intervals. WBR studies were done using a shadow shield whole body counter attached with a 5 inch diameter sodium iodide crystal detector and a 5 mm wide slit collimator. The WBR of Tc-99m MDP at 24 hours was found to be 27.55 ± 6.76% in women in the peri-menopausal age range of 25-45 years. It was also observed that at the time of menopause 13.3% of the women had WBR values above 2 SD of the normal values. This suggests that calcium loss from the skeleton is present only in a small number of women at menopause. However in women who were not supplemented with calcium or subjected to hormonal and calcium treatment, the number of women who showed loss of bone calcium increased within a period of 1-2 years after menopause. This simple method of WBR

  7. Up to one-third of breast cancer cases in post-menopausal Mediterranean women might be avoided by modifying lifestyle habits: the EPIC Italy study.

    Science.gov (United States)

    Masala, Giovanna; Bendinelli, Benedetta; Assedi, Melania; Occhini, Daniela; Zanna, Ines; Sieri, Sabina; Agnoli, Claudia; Sacerdote, Carlotta; Ricceri, Fulvio; Mattiello, Amalia; Panico, Salvatore; Tumino, Rosario; Frasca, Graziella; Saieva, Calogero; Palli, Domenico

    2017-01-01

    Breast cancer (BC) is the most frequent cancer among women in developed countries. Physical activity (PA), body mass index (BMI), and alcohol intake have been identified as relevant lifestyle modifiable risk factors for post-menopausal BC. We aimed to evaluate the role of these factors in modulating post-menopausal BC risk and to estimate the proportion of BC cases attributable to low PA, high BMI, and alcohol taking into account non-modifiable factors. In the Italian section of the EPIC study, 15,010 post-menopausal women were recruited and provided information about dietary and lifestyle habits including PA, smoking, reproductive history, and anthropometric measurements. During 14.8 years of median follow-up, 672 incident BC cases (607 invasive and 65 in situ) were identified. In multivariate models, inverse associations with BC risk emerged for increasing level of total (p trend 0.02), leisure time (p trend 0.04), and occupational (p trend 0.007) PA. High BMI (HR 1.21; 95% CI 1.02-1.43 and HR 1.33; 95% CI 1.06-1.65 for overweight and obesity, respectively) and alcohol consumption higher than 10 g/day (HR 1.30; 95% CI 1.09-1.54) were associated with BC risk. We estimated that 30% (95% CI 8-50%) of post-menopausal BC cases would be avoided through an increase of leisure time PA, a BMI below 25.0, and consuming no more than one drink/day. This large study carried out in Mediterranean women confirms the role of PA, BMI, and alcohol consumption in modulating post-menopausal BC risk and supports the potential benefits obtainable by modifying these lifestyle factors.

  8. The association between breast tissue optical content and mammographic density in pre- and post-menopausal women.

    Directory of Open Access Journals (Sweden)

    Kristina M Blackmore

    Full Text Available Mammographic density (MD, associated with higher water and lower fat content in the breast, is strongly related to breast cancer risk. Optical attenuation spectroscopy (OS is a non-imaging method of evaluating breast tissue composition by red and near-infrared light transmitted through the breast that, unlike mammography, does not involve radiation. OS provides information on wavelength dependent light scattering of tissue and on absorption by water, lipid, oxy-, deoxy-hemoglobin. We propose that OS could be an alternative marker of breast cancer risk and that OS breast tissue measures will be associated with MD. In the present analysis, we developed an algorithm to estimate breast tissue composition and light scattering parameters using a spectrally constrained global fitting procedure employing a diffuse light transport model. OS measurements were obtained from 202 pre- and post-menopausal women with normal mammograms. Percent density (PD and dense area (DA were measured using Cumulus. The association between OS tissue composition and PD and DA was analyzed using linear regression adjusted for body mass index. Among pre-menopausal women, lipid content was significantly inversely associated with square root transformed PD (β = -0.05, p = 0.0002 and DA (β = -0.05, p = 0.019; water content was significantly positively associated with PD (β = 0.06, p = 0.008. Tissue oxygen saturation was marginally inversely associated with PD (β = -0.03, p = 0.057 but significantly inversely associated with DA (β = -0.10, p = 0.002. Among post-menopausal women lipid and water content were significantly associated (negatively and positively, respectively with PD (β lipid = -0.08, β water = 0.14, both p<0.0001 and DA (β lipid = -0.10, p<0.0001; β water = 0.11, p = 0.001. The association between OS breast content and PD and DA is consistent with more proliferation in dense tissue of younger women, greater lipid content in low density tissue and higher water

  9. Responses to concurrent radiotherapy and hormone-therapy and outcome for large breast cancers in post-menopausal women

    International Nuclear Information System (INIS)

    Bollet, Marc A.; Kirova, Youlia M.; Antoni, Guillemette; Pierga, Jean-Yues; Sigal-Zafrani, Brigitte; Laki, Fatima; Campana, Francois; Dendale, Remi; Salmon, Remy; Cottu, Paul; Fourquet, Alain

    2007-01-01

    Introduction: This study aimed to evaluate responses and outcome of hormone-therapy (HT) and radiotherapy (RT) given concurrently for large breast cancers in post-menopausal women. Material and methods: Forty-two breast carcinomas in 41 women were treated with HT and concurrent RT to the breast ± lymph node bearing areas. For 30 tumours this was followed by breast surgery (with axillary lymph node dissection when the axilla had not been irradiated). RT delivered a median dose to the tumour of 50 Gy (48-66) and 75 Gy (65-84) for, respectively, preoperative and exclusive RT-HT. Median follow-up was 64 months. Results: Out of 42 clinically assessable tumours (after a mean dose of 50 Gy), 9 tumours (21%) had complete clinical responses, 24 (57%) partial responses, 9 (21%) stable disease. Breast-conserving surgery or exclusive RT-HT was possible in 74% of tumours. For 29 patients who underwent breast surgery, the rate of pathological complete responses was 17%. At 50 Gy no skin toxicity higher than grade 2 occurred. Five year OS, RFS and local control were, respectively, 85%, 84% and 97%. Lymphoedema occurred in one patient. Conclusion: Concurrent association of RT-HT demonstrated good efficacy, both in terms of clinical and pathological complete responses. It allowed breast conservation with acceptable tolerance and good 5-year local control

  10. Contribution of physical fitness, cerebrovascular reserve and cognitive stimulation to cognitive function in post-menopausal women.

    Science.gov (United States)

    Eskes, Gail A; Longman, Stewart; Brown, Allison D; McMorris, Carly A; Langdon, Kristopher D; Hogan, David B; Poulin, Marc

    2010-01-01

    Studies of the effects of physical fitness on cognition suggest that exercise can improve cognitive abilities in healthy older adults, as well as delay the onset of age-related cognitive decline. The mechanisms for the positive benefit of exercise and how these effects interact with other variables known to influence cognitive function (e.g., involvement in cognitive activities) are less well understood. The current study examined the associations between the physical fitness, cerebrovascular blood flow regulation and involvement in cognitive activities with neuropsychological function in healthy post-menopausal women. Forty-two healthy women between the ages of 55 and 90 were recruited. Physical fitness (V˙O2 max), cerebrovascular reserve (cerebral blood flow during rest and response to an increase in end-tidal (i.e., arterial) PCO2), and cognitive activity (self-reported number and hours of involvement in cognitive activities) were assessed. The association of these variables with neuropsychological performance was examined through linear regression. Physical fitness, cerebrovascular reserve and total number of cognitive activities (but not total hours) were independent predictors of cognitive function, particularly measures of overall cognitive performance, attention and executive function. In addition, prediction of neuropsychological performance was better with multiple variables than each alone. Cognitive function in older adults is associated with multiple factors, including physical fitness, cerebrovascular health and cognitive stimulation. Interestingly, cognitive stimulation effects appear related more to the diversity of activities, rather than the duration of activity. Further examination of these relationships is ongoing in a prospective cohort study.

  11. Disparities of time trends and birth cohort effects on invasive breast cancer incidence in Shanghai and Hong Kong pre- and post-menopausal women.

    Science.gov (United States)

    Wang, Feng; Tse, Lap Ah; Chan, Wing-Cheong; Kwok, Carol Chi-Hei; Leung, Siu-Lan; Wu, Cherry; Mang, Oscar Wai-Kong; Ngan, Roger Kai-Cheong; Li, Mengjie; Yu, Wai-Cho; Tsang, Koon-Ho; Law, Sze-Hong; Miao, Xiaoping; Wu, Chunxiao; Zheng, Ying; Wu, Fan; Yang, Xiaohong R; Yu, Ignatius Tak-Sun

    2017-05-23

    Breast cancer is the leading cause of cancer morbidity among Shanghai and Hong Kong women, which contributes to 20-25% of new female cancer incidents. This study aimed to describe the temporal trend of breast cancer and interpret the potential effects on the observed secular trends. Cancer incident data were obtained from the cancer registries. Age-standardized incidence rate was computed by the direct method using the World population of 2000. Average annual percentage change (AAPC) in incidence rate was estimated by the Joinpoint regression. Age, period and cohort effects were assessed by using a log-linear model with Poisson regression. During 1976-2009, an increasing trend of breast cancer incidence was observed, with an AAPC of 1.73 [95% confidence interval (CI): 1.54-1.92)] for women in Hong Kong and 2.83 (95% CI, 2.26-3.40) in Shanghai. Greater upward trends were revealed in Shanghai women aged 50 years old or above (AAPC = 3.09; 95% CI, 1.48-4.73). Using age at 50 years old as cut-point, strong birth cohort effects were shown in both pre- and post-menopausal women, though a more remarkable effect was suggested in Shanghai post-menopausal women. No evidence for a period effect was indicated. Incidence rate of breast cancer has been more speedy in Shanghai post-menopausal women than that of the Hong Kong women over the past 30 years. Decreased birth rate and increasing environmental exposures (e.g., light-at-night) over successive generations may have constituted major impacts on the birth cohort effects, especially for the post-menopausal breast cancer; further analytic studies are warranted.

  12. Cytokines and T-lymphocyte subsets in healthy post-menopausal women: estrogen retards bone loss without affecting the release of IL-1 or IL-1ra

    DEFF Research Database (Denmark)

    Abrahamsen, Bo; Bendtzen, Klaus; Beck-Nielsen, H

    1997-01-01

    Interleukin (IL)-1 is a potent inducer of bone resorption, and an increased secretion of the IL-1 agonists IL-1 alpha and IL-1 beta relative to the IL-1 receptor antagonist (IL-1ra) has been proposed as a mechanism leading to post-menopausal osteoporosis. T-lymphocytes are capable of secreting bone...... resorptive cytokines and have also been linked with bone metabolism and the development of osteoporosis. Cytokine secretion from whole blood cell cultures was compared between two randomized groups of healthy early post-menopausal women (mean age 52.5 yrs, N = 91) and lymphocyte subsets were quantitated......, and there was no effect of ERT on lymphocyte subsets. The number of CD3+ CD56+ T-cells showed a highly significant negative correlation with femoral and lumbar bone density in untreated women (r = -0.42, p osteoporosis, indicating that these adherent mononuclear...

  13. Polymorphisms in the P2X7 receptor gene are associated with low lumbar spine bone mineral density and accelerated bone loss in post-menopausal women

    DEFF Research Database (Denmark)

    Gartland, Alison; Skarratt, Kristen K; Hocking, Lynne J

    2012-01-01

    the functional P2RX7 SNPs are associated with lumbar spine (LS) bone mineral density (BMD), a key determinant of vertebral fracture risk, in post-menopausal women. We genotyped 506 post-menopausal women from the Aberdeen Prospective Osteoporosis Screening Study (APOSS) for the above SNPs. Lumbar spine BMD...... SNPs (n=48) had nearly ninefold greater annualised percent change in LS-BMD than subjects who were wild type at the six SNP positions (n=84; rate of loss=-0.94%/year and -0.11%/year, respectively, P=0.0005, unpaired t-test). This is the first report that describes association of the c.946A (p.Arg307Gln...

  14. Evaluation of the prevalence and correlated factors for decreased bone mass density among pre- and post-menopausal educated working women in Saudi Arabia.

    Science.gov (United States)

    Mahboub, Samira M; Al-Muammar, May N; Elareefy, Azza A

    2014-09-01

    Most of the previous studies on osteoporosis have focused on post-menopausal women, and more research is needed to evaluate its prevalence in pre-menopausal women. This study was carried out to evaluate the prevalence and correlated factors for decreased bone mass density among pre- and post-menopausal women. This was a cross-sectional study carried out in Applied Medical Sciences College under King Saud University. All pre- and post-menopausal women working there were invited to participate in the study. Measurement of bone mass density was done by quantitative ultrasound densitometry. One-fourth of the pre-menopausal females had osteopaenia. There was a significant correlation between having osteoporosis and increasing age, fertility period, parity, menopausal duration, gynaecological age, and presence of co-morbidity, especially hypertension and diabetes mellitus. Pre-menopausal females had high prevalence of osteopaenia (24.8%), and it is recommended to implement health education campaigns demonstrating the preventive measures of osteoporosis.

  15. A comparison of gluteus medius, gluteus minimus and tensor facia latae muscle activation during gait in post-menopausal women with and without greater trochanteric pain syndrome.

    Science.gov (United States)

    Ganderton, Charlotte; Pizzari, Tania; Harle, Tanya; Cook, Jill; Semciw, Adam

    2017-04-01

    The effect of greater trochanteric pain syndrome (GTPS) on gluteus medius (GMed) and minimus (GMin) activation in post-menopausal women is unknown. The aim of this study was to compare segmental muscle activation and variability of the GMed, GMin and tensor fascia latae (TFL) during gait in post-menopausal women with and without GTPS. Intramuscular electrodes were inserted into segments of GMin (x2) and GMed (x3) and a surface electrode placed on TFL. Ten control participants and 8 with GTPS completed six walking trials. Peak amplitude, average amplitude and time to peak from each phase of the gait cycle (0-30%, 30%- toe off (TO), total stance and swing) were compared between groups using independent t-tests and effect-size (ES) calculations. Variability of muscle activation was calculated using the mean coefficient of variation (CV). Reversal of anterior GMin electromyographic burst pattern and greater average muscle activity was found in the GTPS group compared to controls: 0-TO for anterior GMin (p<0.05), anterior and middle GMed (p<0.01); 0-30% for posterior GMin (p<0.01) and GMed (p<0.05). No significant differences were identified in TFL. Overall, this study found increased segmental gluteal muscle activation, decreased hip abduction strength, and reduced variability in muscle activation in post-menopausal women with GTPS, compared with controls. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. Effects of Resveratrol on Cognitive Performance, Mood and Cerebrovascular Function in Post-Menopausal Women; A 14-Week Randomised Placebo-Controlled Intervention Trial

    Directory of Open Access Journals (Sweden)

    Hamish M. Evans

    2017-01-01

    Full Text Available We tested whether chronic supplementation with resveratrol (a phytoestrogen could improve cerebrovascular function, cognition and mood in post-menopausal women. Eighty post-menopausal women aged 45–85 years were randomised to take trans-resveratrol or placebo for 14 weeks and the effects on cognitive performance, cerebral blood flow velocity and pulsatility index (a measure of arterial stiffness in the middle cerebral artery (using transcranial Doppler ultrasound, and cerebrovascular responsiveness (CVR to both cognitive testing and hypercapnia were assessed. Mood questionnaires were also administered. Compared to placebo, resveratrol elicited 17% increases in CVR to both hypercapnic (p = 0.010 and cognitive stimuli (p = 0.002. Significant improvements were observed in the performance of cognitive tasks in the domain of verbal memory (p = 0.041 and in overall cognitive performance (p = 0.020, which correlated with the increase in CVR (r = 0.327; p = 0.048. Mood tended to improve in multiple measures, although not significantly. These results indicate that regular consumption of a modest dose of resveratrol can enhance both cerebrovascular function and cognition in post-menopausal women, potentially reducing their heightened risk of accelerated cognitive decline and offering a promising therapeutic treatment for menopause-related cognitive decline.

  17. Screening for osteoporosis among post-menopausal women in community pharmacy

    Directory of Open Access Journals (Sweden)

    Barris Blundell D

    2006-06-01

    Full Text Available Objectives: To identify postmenopausal women with risk of osteoporosis through quantitative ultrasound imaging (QUI and to value the medical intervention after the determination of the bone mineral density (BMD. Methods: Cross-sectional descriptive study developed in a community pharmacy. During the month of June of 2005 the community pharmacy enrolled postmenopausal women into the study. Women in treatment with calcium, vitamin D, hormone replacement therapy, estrogen receptor modulators, calcitonin or biphosphonates were considered criteria for exclusion. To all the women that consent to participate, the pharmacist measured BMD with the device Sahara Hologic Ultrasound Bone Densitometer at right calcaneus. Following the World Health Organization, women were classified as osteoporotic if their T-Score was less than -2.5 and as osteopenic if their T-Score ranged between -2.5 and -1.0. Results: Of the 100 women screened, 11 (11% presented risk of osteoporosis and 61 (61% of osteopenia. The 18.5% postmenopausal women with body mass index lesser than 30 presented risk of osteoporosis and the 63.0% osteopenia. Conclusions: The QUI constitutes a useful tool in community pharmacy for the screening of osteoporosis and it supposes a greater integration of the community pharmacy within the health care.

  18. Soyfood consumption and risk of glycosuria in post-menopausal women

    Directory of Open Access Journals (Sweden)

    Nurmillah Nurmillah

    2016-02-01

    Full Text Available Menopause is a natural event to be experienced by every woman and appears to be associated with increased risk for developing type 2 diabetes mellitus. It has been postulated that a diet high in legumes may be beneficial for the prevention of glycosuria. These unique components of soy have been shown to have beneficial effects on glucose and insulin homeostasis. The objective of the present study was to examine the possibility of an association between soy food consumption and risk of glycosuria in postmenopausal women. A cross-sectional study was conducted among 94 postmenopausal women attending Mampang Prapatan Health Center, Mampang Prapatan subdistrict, South Jakarta. Anthropometric measurements were taken using standard instruments and dietary intake was assessed with a validated food-frequency questionnaire. A dipstick semiquantitative assay for urinary glucose was used to define glycosuria (positive. The results showed that 12.8% of postmenopausal women had glycosuria and mean isoflavone intake was 69.5 ± 61.4 g/d. Intake of isoflavone was inversely associated with risk of glycosuria. Compared to women in the lowest quintile of isoflavone intake (Q1, postmenopausal women in the highest quintile (Q5 had a lower risk for glycosuria of 0.30 times that of Q1, which risk was however statistically not significant (OR = 0.30; 95% CI = 0.02 – 3.14. In conclusion, isoflavone may play a role in the prevention of glycosuria (an important indicator of diabetes among postmenopausal women.

  19. Soyfood consumption and risk of glycosuria in post-menopausal women

    Directory of Open Access Journals (Sweden)

    Nurmillah

    2010-12-01

    Full Text Available Menopause is a natural event to be experienced by every woman and appears to be associated with increased risk for developing type 2 diabetes mellitus. It has been postulated that a diet high in legumes may be beneficial for the prevention of glycosuria. These unique components of soy have been shown to have beneficial effects on glucose and insulin homeostasis. The objective of the present study was to examine the possibility of an association between soy food consumption and risk of glycosuria in postmenopausal women. A cross-sectional study was conducted among 94 postmenopausal women attending Mampang Prapatan Health Center, Mampang Prapatan subdistrict, South Jakarta. Anthropometric measurements were taken using standard instruments and dietary intake was assessed with a validated food-frequency questionnaire. A dipstick semiquantitative assay for urinary glucose was used to define glycosuria (positive. The results showed that 12.8% of postmenopausal women had glycosuria and mean isoflavone intake was 69.5 ± 61.4 g/d. Intake of isoflavone was inversely associated with risk of glycosuria. Compared to women in the lowest quintile of isoflavone intake (Q1, postmenopausal women in the highest quintile (Q5 had a lower risk for glycosuria of 0.30 times that of Q1, which risk was however statistically not significant (OR = 0.30; 95% CI = 0.02 – 3.14. In conclusion, isoflavone may play a role in the prevention of glycosuria (an important indicator of diabetes among postmenopausal women.

  20. Periodontitis and bone mineral density among pre and post menopausal women: A comparative study

    Directory of Open Access Journals (Sweden)

    Suresh Snophia

    2010-01-01

    Full Text Available Aim: The aim of the study was to assess the relationship between bone mineral density and periodontitis in premenopausal and postmenopausal women. Materials and Methods: Twenty women between the age group of 45-55 years were selected for this study. Ten premenopausal women with healthy periodontium constituted the control group and 10 postmenopausal women with ≥2mm of clinical attachment loss in> 30% of sites constituted the study group. All patients were assessed for plaque index, probing depth and clinical attachment loss. Radiographs (six IOPA and two posterior bitewing were taken and assessed for interproximal alveolar bone loss. The patients were scanned to assess the bone mineral density of lumbar spine (L2 and femur using dual energy X-ray absorptiometry (DEXA. Results: The bone mineral densities of lumbar spine (L2 and femur were significantly lower in the study group than the control group. Osteopenia of the lumbar spine and femur was observed in 60% whereas osteoporosis of lumbar spine was observed in 30% of cases in study group. Conclusion: Increased proportion of osteopenia and osteoporosis cases of lumbar spine and femur in postmenopausal women with periodontitis suggests that there is association between bone mineral density and periodontitis.

  1. Loading intensity of jumping exercises in post-menopausal women: Implications for osteogenic training

    DEFF Research Database (Denmark)

    Smale, K B; Hansen, L H; Kristensen, J K

    2018-01-01

    Post‐menopausal women frequently exhibit low bone mineral density, and therefore, evidence‐based exercises that induce osteogenic loading and prevent osteoporosis are often essential. The purpose of this study was to investigate the loading intensity of 3 different jumping exercises in post‐menop...

  2. [Periodontal disease in women in post-menopause and its relationship with osteoporosis].

    Science.gov (United States)

    Bertulucci, Lívia de Almeida Barros; Pereira, Flavia Maria Barros Guimarães; de Oliveira, Ana Emília Figueiredo; Brito, Luciane Maria Oliveira; Lopes, Fernanda Ferreira

    2012-12-01

    To investigate the relationship between periodontitis and osteoporosis, using a case-control study about periodontal status of postmenopausal women. A total of 99 postmenopausal women were divided into three groups: normal bone (Gn, n=45), osteopenia (Gpenia, n=31) and osteoporosis (Gporosis, n=23). The categorization of bone mass was measured by dual energy absorptiometry with X-rays in the lumbar spine (L2 - L4), by assessing bone mineral density. Clinical attachment level (CAL), gingival bleeding index (GI), plaque index (PI), and probing depth (PD) were determined in all participants by a single examiner. The data were submitted to BioEstat 2.0 software through parametric analysis of variance (ANOVA) and the Bonferroni test, with the level of significance set at 5%. Women with osteoporosis presented the highest percentage of periodontal disease, with higher average CAL (2.6±0.4 mm) and PD (2.8±0.6 mm), GI (72.8±25.9 mm) and PI (72.9±24.2 mm). Statistical analysis revealed a significant difference in periodontal situation between Gn and Gporosis (p=0,01) and between Gpenia and Gporosis (p=0,03). Osteoporosis may have an influence on periodontal condition, based on the relation between periodontitis and osteoporosis in postmenopausal women.

  3. Influence of diet, exercise and serum vitamin D on sarcopenia in post-menopausal women

    Science.gov (United States)

    Mason, Caitlin; Xiao, Liren; Imayama, Ikuyo; Duggan, Catherine R.; Foster-Schubert, Karen E.; Kong, Angela; Campbell, Kristin L.; Wang, Ching-Yun; Villasenor, Adriana; Neuhouser, Marian L.; Alfano, Catherine M.; Blackburn, George L.; McTiernan, Anne

    2012-01-01

    Purpose To investigate the effects of 12 months of dietary weight loss and/or aerobic exercise on lean mass and the measurements defining sarcopenia in postmenopausal women, and to examine the potential moderating effect of serum 25-hydroxyvitamin D (25(OH)D) and age. Methods 439 overweight and obese postmenopausal women were randomized to: diet modification (N=118); exercise (N=117), diet+exercise (N=117), or control (N=87). The diet intervention was a group-based program with a 10% weight loss goal. The exercise intervention was 45 mins/day, 5 days/week of moderate-to-vigorous intensity aerobic activity. Total and appendicular lean mass were quantified by dual Xray absorptiometry (DXA) at baseline and 12 months. A skeletal muscle index (SMI=appendicular lean mass (kg)/m2) and the prevalence of sarcopenia (SMIlean mass, and a borderline significant decrease in appendicular lean mass and SMI compared to controls. In contrast, aerobic exercise significantly preserved appendicular lean mass and SMI. Diet + exercise attenuated the loss of appendicular lean mass and SMI compared to diet alone, and did not result in significant loss of total- or appendicular lean mass compared to controls. Neither serum 25(OH)D nor age were significant moderators of the intervention effects. Conclusions Aerobic exercise added to dietary weight loss can attenuate the loss of appendicular lean mass during weight loss, and may be effective for the prevention and treatment of sarcopenia among overweight and obese postmenopausal women. PMID:23190588

  4. Histological pattern of endometrial samples in post-menopausal women with abnormal uterine bleeding

    International Nuclear Information System (INIS)

    Deeba, F.; Shaista, A.; Khan, B.

    2017-01-01

    Abnormal uterine bleeding is one of the most common clinical problems in gynaecological practice and is an indicator of various underlying disorders. An endometrial biopsy should be done in all women over 35 years with AUB to rule out endometrial cancer or pre-malignant lesion and to initiate treatment. However, wide range of histological patterns on endometrial biopsy offer a diagnostic challenge to practicing pathologists. The objective of this study was to determine histological patterns of endometrium in postmenopausal women with abnormal uterine bleeding. Methods: This cross-sectional study was conducted in the department of obstetrics and gynaecology, Benazir Bhutto Shaheed women and children teaching hospital, Abbottabad from 15/11/2014 to 14/05/2015. This study involved 110 postmenopausal women presenting with abnormal uterine bleeding. A written informed consent was obtained from every patient. Results: The mean age of the patients was 61.60+-6.17 years and the mean duration of AUB was 5.20+-2.80 years. Most of the patients were para 6 (28.2 percent) and para 5 (28.2 percent) followed by para 4 (18.2 percent) and para 3 (17.3 percent) while only 8.2 percent were para 1. The most common histological pattern observed was complex hyperplasia without atypia (30.9 percent) followed by atrophic endometrium (24.5 percent), simple hyperplasia (23.6 percent), malignancy (12.7 percent), complex hyperplasia with atypia (4.5 percent) and benign endometrial polyp (3.6 percent). When stratified the data, there was no significant difference of histological patterns across various age groups (p=.673), duration of AUB (p=.064) and parity (p=.242). Conclusion: The most common histological pattern observed in postmenopausal women with AUB was complex hyperplasia without atypia (30.9 percent) followed by atrophic endometrium (24.5 percent), simple hyperplasia (23.6 percent), malignancy (12.7 percent), complex hyperplasia with atypia (4.5 percent) and benign endometrial polyp

  5. Role of transvaginal ultrasonography in diagnosing endometrial hyperplasia in pre- and post-menopause women

    OpenAIRE

    Shokouhi, Behrooz

    2015-01-01

    Background: Abnormal uterine bleeding (AUB) is the most common presenting symptom of endometrial hyperplasia (EH). Transvaginal ultrasonography (TVS) is a diagnostic tool in the evaluation of AUB and EH with various sensitivity and specificity. However, the exact accuracy of TVS in diagnosing EH had not been evaluated. In this study, we aim to evaluate the accuracy of TVS in detecting EH. Materials and Methods: In this retrospective study, 120 women (mean age of 48.64 ± 6.74 years) with AUB w...

  6. Food matrix and isoflavones bioavailability in early post menopausal women: An European clinical study

    Directory of Open Access Journals (Sweden)

    Brigitte Chanteranne

    2008-12-01

    Full Text Available Brigitte Chanteranne1,2, Francesco Branca3, A Kaardinal4, K Wahala5, Véronique Braesco6, Philippe Ladroite7, Fred Brouns8, Véronique Coxam1,21INRA, Centre Clermont-Ferrand – Theix, UMR1019, Unité Nutrition Humaine, St Genès Champanelle, France; 2Univ Clermont 1, UFR Médecine, UMR1019, Unité Nutrition Humaine, Clermont-Ferrand, France; 3INRAN, Human Nutrition Unit, Ardeatina, Rome, Italy; 4TNO Nutrition and Food Research, Zeist, The Netherlands; 5Department of Chemistry, University of Helsinki, Helsinki, Finland; 6Danone Vitapole, Le Plessis Robinson, France; 7Nutrition Santé, Ravel, France; 8Eridania Beghin Say, Vilvoorde Research and Development Centre, Vilvoorde, BelgiumAbstract: The estrogenic effects of soy isoflavones (IF on symptoms of menopause are of particular interest. The aim of the present study was to improve compliance of IF in two IF-enriched foods providing the same IF circulating levels in postmenopausal women. Forty-two healthy postmenopausal women (mean age: 53.28 years were recruited for a randomized, crossover, multicenter trial conducted in the Netherlands, Italy and France. Over 18 days, volunteers were assigned to two groups and supplemented with two different IF-enriched foods (100 mg IF aglycones/two servings. The first group had to eat two biscuits daily for three days. After a wash-out period (11 d, they received cereal bars for three days. The second group started with the cereal bars and finished with biscuits. After IF intake, plasma and urinary levels of genistein, daidzein, O desmethyl angolensin and equol significantly increased and returned to baseline level after the washout period. There was no difference between biscuits and cereals bars intake, as shown by group values at each end of experimental period (day 4 or day 18. Both matrixes are comparable in terms of IF-circulating levels and could be used independently.Keywords: soy isoflavones, bioavailability, food processing, postmenopausal women

  7. Evaluation of the Association Between Periodontal Parameters Osteoporosis and Osteopenia in Post Menopausal Women

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    Amir Moeintaghavi

    2013-01-01

    Full Text Available Objective: Different studies have reported contradictory results about the effect of osteoporosis on periodontal status. We performed this study to evaluate the periodontal status of menopausal women by methods with enough accuracy and confidence.Materials and Methods: This study was performed based on the evaluation of bone mineral density using dual energy X-ray absorptiometry in 2010. A total of 60 patients who met the inclusion criteria were selected and divided into three groups of osteoporosis, osteopenia, and normal. Then, evaluation of periodontal markers such as pocket depth (DP, attachment loss (AL, and tooth loss (TL was performed by a dental student. A panoramic radiography was performed for those who were suspicious of periodontal disease and bone decline. Finally, evaluation of the periodontal indexes was compared among the three groups using ANOVA with 95% confidence interval.Results: Mean bone decline was higher in the osteoporosis group compared to the other two groups, but the difference was not significant (P=0.065. In addition, mean of plaque index (P=0.123, pocket depth (P=0.856, attachment loss (p=0.525, and tooth loss (p=0.884, the number of people with attachment loss ≥ 2millimeter (P=0.866 and the number of people with alveolar bone loss ≥ 2 millimeter (P=0.348 were not significantly different between the three groups.Conclusion: In this study, no significant difference was observed between the three groups in terms of plaque index, pocket depth, attachment loss, or tooth loss. However, further studies are required that could control all the possible confounding variables.

  8. Evaluation of the association between periodontal parameters, osteoporosis and osteopenia in post menopausal women.

    Science.gov (United States)

    Moeintaghavi, Amir; Pourjavad, Monireh; Dadgar, Sepideh; Tabbakh, Najmeh Shayesteh

    2013-09-01

    Different studies have reported contradictory results about the effect of osteoporosis on periodontal status. We performed this study to evaluate the periodontal status of menopausal women by methods with enough accuracy and confidence. This study was performed based on the evaluation of bone mineral density using dual energy X-ray absorptiometry in 2010. A total of 60 patients who met the inclusion criteria were selected and divided into three groups of osteoporosis, osteopenia, and normal. Then, evaluation of periodontal markers such as pocket depth (DP), attachment loss (AL), and tooth loss (TL) was performed by a dental student. A panoramic radiography was performed for those who were suspicious of periodontal disease and bone decline. Finally, evaluation of the periodontal indexes was compared among the three groups using ANOVA with 95% confidence interval. Mean bone decline was higher in the osteoporosis group compared to the other two groups, but the difference was not significant (P=0.065). In addition, mean of plaque index (P=0.123), pocket depth (P=0.856), attachment loss (p=0.525), and tooth loss (p=0.884), the number of people with attachment loss ≥ 2millimeter (P=0.866) and the number of people with alveolar bone loss ≥ 2 millimeter (P=0.348) were not significantly different between the three groups. In this study, no significant difference was observed between the three groups in terms of plaque index, pocket depth, attachment loss, or tooth loss. However, further studies are required that could control all the possible confounding variables.

  9. First-line treatment disruption among post-menopausal women with HR+/HER2- metastatic breast cancer: a retrospective US claims study.

    Science.gov (United States)

    Tang, Derek H; Li, Nanxin; Du, Ella X; Peeples, Miranda; Chu, Lihao; Xie, Jipan; Barghout, Victoria

    2017-12-01

    This study assessed disruption of first-line treatments initiated after the approval of the first CDK 4/6 inhibitor, palbociclib, among post-menopausal women with HR+/HER2- metastatic breast cancer (mBC) in the US. Post-menopausal women with HR+/HER2- mBC who initiated first-line endocrine therapy or chemotherapy (index therapy) between February 3, 2015 (palbociclib approval date) and February 29, 2016 (end of data) were identified from the Symphony Source Lx database. Patients were required to have continuous quarterly activity (defined as ≥1 pharmacy or medical claim) for 12 months prior to and 1 month after the initiation of the index therapy (index date). Treatment disruption was defined as a treatment gap of ≥60 days or adding an agent after the original therapy. Kaplan-Meier analyses were conducted to estimate treatment disruption rates during the 6 months following the index date. Patients without treatment disruption were censored at the end of continuous quarterly activity or end of data. A total of 8,160 and 2,153 eligible patients initiated endocrine therapy or chemotherapy as their first-line mBC treatment, with a median follow-up of 6.7 and 7.6 months, respectively. The three most prevalent metastatic sites were bone (28.1-42.2%), liver (8.8-17.3%), and lung (8.6-9.5%). Overall, 37.7% (n = 3,074) of patients receiving endocrine therapy and 86.1% (n = 1,852) of patients receiving chemotherapy encountered treatment disruption at 6 months (log-rank test p disruption rates of first-line therapies were sub-optimal among post-menopausal women with HR+/HER2- mBC, primarily driven by chemotherapy users. New therapies or interventions are needed to reduce treatment disruption in this patient population.

  10. Nonoperative management of atypical endometrial hyperplasia and grade 1 endometrial cancer with the levonorgestrel intrauterine device in medically ill post-menopausal women.

    Science.gov (United States)

    Baker, William D; Pierce, Stuart R; Mills, Anne M; Gehrig, Paola A; Duska, Linda R

    2017-07-01

    To assess the endometrial response rates to treatment with the levonorgestrel intrauterine device in post-menopausal women with atypical hyperplasia/endometrial intraepithelial neoplasia and grade 1 endometrioid (AH/EC) endometrial carcinoma who are not surgical candidates. Chart review was undertaken of patients with AH/EC who underwent levonorgestrel intrauterine device insertion by a gynecologic oncologist within two academic health systems between 2002 and 2013. When available, tissue blocks were evaluated with immunohistochemical staining for progesterone receptor expression. A total of 41 patients received treatment for AH/EC with the levonorgestrel intrauterine device. Follow up sufficient to assess response occurred in 36 women (88%). Complete response was documented in 18 of 36 women (50%), no response in 8 patients (22%), partial response in 3 women (8%) and progression of disease in 7 patients (19%). Four of 18 patients with complete response (22%) later experienced relapse of hyperplasia or cancer. Four patients (10%) died during the study period: none had evidence of metastatic disease and 1 of the 4 woman died of perioperative complications following hysterectomy for stage I disease. Patients responding to treatment had significantly lower progesterone receptor expression on post-treatment biopsies. Intrauterine levonorgestrel is a viable treatment option for post-menopausal women with AH/EC who are poor candidates for standard surgical management. The response rate in this series is similar to published reports in premenopausal patients and includes cases of disease recurrence following conversion to benign endometrium. Copyright © 2017 Elsevier Inc. All rights reserved.

  11. Deuterium-labeled steroids for study in humans. II. Preliminary studies on estrogen production rates in pre- and post-menopausal women

    Energy Technology Data Exchange (ETDEWEB)

    Pinkus, J.L.; Charles, D.; Chattoraj, S.C.

    1979-01-01

    6,7-Dideuterio-3-hydroxy-1,3,5(10)-estratrien-17-one (dideuterio-estrone) and 4-deuterio-1,3,5(10)-estratriene-3,17 beta-diol (monodeuterio-17 beta-estradiol) were used for the estimation of estrogen production rates in pre- and post-menopausal women. The results are concordant with those obtained by radioisotope administration as reported in the literature. This preliminary study suggests that one or more steroids labeled with one or multiple deuterium and/or other stable isotopes may be employed for the measurement of production rates of steroid hormones which are derived from multiple precursors.

  12. Long-term aerobic exercise and omega-3 supplementation modulate osteoporosis through inflammatory mechanisms in post-menopausal women: a randomized, repeated measures study

    Directory of Open Access Journals (Sweden)

    Kanaley Jill

    2011-10-01

    Full Text Available Abstract Background Evidence indicates that dietary fats and physical activity influence bone health. The purpose of this study was to examine the effects of long-term aerobic exercise and omega-3 (N-3 supplementation on serum inflammatory markers, bone mineral density (BMD, and bone biomarkers in post-menopausal women. Methods Seventy-nine healthy sedentary post-menopausal women aged 58-78 years participated in this study. Subjects were randomized to one of 4 groups: exercise + supplement (E+S, n = 21, exercise (E, n = 20, supplement (S, n = 20, and control (Con, n = 18 groups. The subjects in the E+S and E groups performed aerobic exercise training (walking and jogging up to 65% of HRmax, three times a week for 24 weeks. Subjects in the E+S and S groups consumed 1000 mg/d N-3 for 24 weeks. The lumbar spine (L2-L4 and femoral neck BMD, serum tumor necrosis factor (TNF α, interleukin (IL 6, prostaglandin (PG E2, estrogen, osteocalcin, 1, 25-dihydroxyvitamin D3 (1, 25 Vit D, C-telopeptide (CTX, parathyroid hormone (PTH and calcitonin (CT were measured at baseline, the end of week 12 and 24. Results Serum estrogen, osteocalcin, 1, 25 Vit D, CT, L2-L4 and femoral neck BMD measures increased (P 2 decreased (P 2-L4 and femoral neck BMD, estrogen, osteocalcin, and CT were negatively (P 2. PTH and CT were correlated positively and negatively with IL-6, respectively (P Conclusions The present study demonstrates that long-term aerobic exercise training plus N-3 supplementation have a synergistic effect in attenuating inflammation and augmenting BMD in post-menopausal osteoporosis.

  13. Association between circulating levels of adiponectin and indices of bone mass and bone metabolism in middle-aged post-menopausal women.

    Science.gov (United States)

    Tenta, R; Kontogianni, M D; Yiannakouris, N

    2012-03-01

    Adiponectin, a fat derived cytokine, is a potential independent contributor to bone mineral density (BMD); however, its action on bone metabolism in humans is still unclear. The aim of this study was to investigate the relationship of adiponectin with bone mass indices and bone metabolic markers in middle-aged post-menopausal women without diabetes. A random sample consisted of 81 post-menopausal women (age range 45-61 yr, osteopenic/osteoporotic no.=43) was studied. Lumbar-spine BMD (BMD(L2-L4)) and total-body bone mineral content (TBBMC) were measured with dual X-ray absorptiometry. Plasma levels of total and high-molecular weight (HMW) adiponectin, osteoprotegerin (OPG), soluble receptor activator of nuclear factor-κB ligand (sRANKL) and IGF-I were determined. No association was observed between total or HMW adiponectin and BMD(L2-L4) or TBBMC. On the contrary, adiponectin levels were positively associated with OPG levels (partial r=0.276, p=0.015) and negatively with IGF-I (partial r=-0.438, pfailed to show statistically significant association between circulating adiponectin levels and indices of bone mass in women during the postmenopausal period, we showed significant associations with OPG and IGF-I levels, suggesting an anabolic role of adiponectin, which may contribute in the understanding of the interplay between adipose tissue-derived hormones and bone metabolism. © 2012, Editrice Kurtis.

  14. Correlation of physical aptitude; functional capacity, corporal balance and quality of life (QoL) among elderly women submitted to a post-menopausal physical activities program.

    Science.gov (United States)

    de Souza Santos, César Augusto; Dantas, Estélio Enrique Martin; Moreira, Maria Helena Rodrigues

    2011-01-01

    The objective of this study was to evaluate the effect of physical activity from the "Menopause in Form" program on physical aptitude, functional capacity, corporal balance and QoL among elderly women. In addition, correlations among these variables were examined. The present work was a longitudinal study that was quasi-experimental and correlational. A total of 323 elderly women (age: 69.0±5.53 years) participated in this study. Subjects were non-institutionalized, post-menopausal individuals residing at the Elderly Care Center in Belém Municipality (Pará, Brazil) and practiced one activity (i.e., dancing or walking) over a 10-month period. The assessment protocols used were the following: the Fullerton functional fitness test battery (physical aptitude); the activities of daily living (ADL) indices (functional capacity); the Tinetti-scale (corporal balance); and the WHOQOL-OLD questionnaire (QoL). The adopted significance level was pcapacity (Δ%=5.63%; p=0.0001) and general QoL (Δ%=9.19%; p=0.001). These results suggest that the physical activities employed during the "Menopause in Form" program resulted in significant improvements in the functional capacity and QoL of post-menopausal elderly women. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  15. Association of collagen type I alpha1 (COLIA1) Sp1 polymorphism with osteoporotic fracture in Caucasian post-menopausal women: a meta-analysis.

    LENUS (Irish Health Repository)

    Ji, G-R

    2012-01-06

    This study was designed to summarize quantitatively the evidence for a relationship between collagen type I alpha1 (COLIA1) Sp1 polymorphism and osteoporotic fracture risk in Caucasian post-menopausal women. This meta-analysis included 16 studies, which analysed 2294 patients with fractures and 10 285 controls. The combined results showed that there was a significant difference in genotype distribution (SS odds ratio [OR] 0.72; Ss OR 1.18; ss OR 1.97) between patients with fractures and controls. When stratifying by the fracture site, it was found that: (i) patients with vertebral fractures had a significantly higher frequency of the Ss genotype and a lower frequency of the SS genotype than controls; and (ii) patients with non-vertebral fractures had a significantly higher frequency of the ss genotype and a lower frequency of the SS genotype than controls. This meta-analysis suggests that the COLIA1 Sp1 polymorphism may be associated with osteoporotic fracture in Caucasian post-menopausal women.

  16. Voiding characteristics and related hormonal changes in peri-menopausal and post-menopausal women: a preliminary study.

    Science.gov (United States)

    Kwon, Jong Kyu; Kim, Jae Heon; Choi, Hoon; Chang, In Ho; Park, Bo Ra; Kwon, Soon-Sun; Lee, Eun Sil; Choi, Gyu Yeon; Lee, Jeong Jae; Lee, Im Soon

    2014-11-01

    To characterize voiding symptoms during the peri- and post-menopausal periods and to investigate related hormonal changes. We enrolled a total of 55 patients between February 10, 2013, and August 15, 2013, to participate in this cross-sectional study. To characterize patients' voiding symptoms, we administered voiding questionnaires, including the International Prostate Symptom Score (IPSS), Overactive Bladder Symptom Score (OABSS), and Sandvik Severity Index. Measured hormones included E2, FSH, TSH, prolactin, progesterone, and testosterone. In the univariate analysis, there were significant intergroup differences for all of the hormones except progesterone. Among the voiding symptoms, straining (IPSS question 1), frequency (IPSS question 2), and SUI were significantly different between the two groups (p=0.039. 0.010, and 0.017, respectively). In the multivariate analysis, frequency (IPSS question 2) and SUI were significantly different between the two groups (p=0.020 and 0.011, respectively). Among the hormones, only testosterone was marginally different between the two groups (p=0.059). During the transition to menopause, voiding symptoms, such as frequency, can potentially worsen in the peri-menopausal period, and SUI is more prevalent in the post-menopausal period. Additionally, testosterone may have a role in voiding changes that occur during the menopausal transition. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  17. An exploratory study into the effect of exhausting bicycle exercise on endocrine and immune responses in post-menopausal women : Relationships between vigour and plasma cortisol concentrations and lymphocyte proliferation following exercise

    NARCIS (Netherlands)

    van der Pompe, G; Bernards, N; Kavelaars, A; Heijnen, C

    It is well-established that bicycle exercise alters the endocrine and immune responses in men, but little information is available for women, especially middle-aged, post-menopausal women. The purpose of our study was to document the endocrine and immune reactivity to exhausting bicycle exercise in

  18. Use of digital panoramic radiography as an auxiliary means of low bone mineral density detection in post-menopausal women.

    Science.gov (United States)

    Valerio, C S; Trindade, A M; Mazzieiro, E T; Amaral, T P; Manzi, F R

    2013-01-01

    To correlate the radiomorphometric indices obtained using digital panoramic radiography (DPR) with bone mineral densities, evaluated by the dual-energy X-ray absorptiometry test, in a population of post-menopausal females to identify patients with asymptomatic low bone mineral densities. The morphology of the mandibular cortex was evaluated using the mandibular cortical index (MCI) and the inferior mandibular cortex width was evaluated using the mental index (MI) in 64 female patients who had undergone dual-energy X-ray absorptiometry assessment. Of these patients, 21 were diagnosed with osteopaenia and 20 with osteoporosis, and 23 were normal. Three new indices for evaluating the inferior mandibular cortex width were designed: the mental posterior index 1 (MPI1), MPI2 and MPI3. Statistical analyses were performed using the χ(2) and Kruskal-Wallis tests and the receiver operating characteristic curve. There were significant differences between the normal and lower bone mineral density groups (osteopaenia and osteoporosis) for MCI (p < 0.01). In the osteoporosis group, the MI, MPI1, MPI2 and MPI3 were significantly different from the normal and osteopaenia groups (p < 0.05). The MI, MPI1, MPI2 and MPI3 showed that there is an area in the mandibular cortex, located between the mental foramen and the antegonial region, which is valid for identifying females at high risk for osteoporosis. The MCI, MI, MPI1, MPI2, and MPI3 radiomorphometric indices evaluated using DPR can be used to identify post-menopausal females with low bone densities and to provide adequate medical treatment for them.

  19. Fatores associados à dislipidemia na pós-menopausa Factors associated with women's dyslipidemia in the post-menopause

    Directory of Open Access Journals (Sweden)

    Ticihana Ribeiro de Oliveira

    2008-12-01

    sample showed to be homogeneous for the socioeconomic characteristics (income, occupation and schooling, physical activity practice, etilism and tabagism, and food ingestion, with no significant correlation with dyslipidemia. The groups presented an income up to two minimal wages, low schooling level (up to the fourth grade of lower school, and the housewife occupation. Smoking and drinking alcohol was not very frequent. Practicing physical activity was non-existent, thus characterizing a sedentary population. Food ingestion was adequate for carbohydrates, protein, lipids, but not for cholesterol (excessive and fibers (insufficient, in both groups. Concerning the anthropometric evaluation, there has been an association with dyslipidemia, as the body mass index (BMI and the waist circumference (WC were significantly larger in case than in control. The waist-hip ratio has been similar in both groups. Weight excess has been found in most of the cases (73.3% as almost half of them (44% presented WC >88 cm, which represents a very increased risk. CONCLUSIONS: it is possible to conclude that, in the studied sample, only the anthropometric measurements have been considered as risk factors associated with dyslipidemia, during post-menopause.

  20. Using Radon transform of standard radiographs of the hip to differentiate between post-menopausal women with and without fracture of the proximal femur.

    Science.gov (United States)

    Boehm, H F; Lutz, J; Körner, M; Mutschler, W; Reiser, M; Pfeifer, K-J

    2009-02-01

    Texture features based on the Radon transform were extracted from clinical radiographs of the hip in post-menopausal women. The novel algorithm allowed us to identify patients with fracture of the proximal femur and may provide an alternative to measuring bone mineral density in predicting the fracture-risk in osteoporosis, especially where densitometry is regionally unavailable. The aim of this study is to introduce an algorithm for differentiation between patients with and without fracture of the hip using parameters based on the Radon transform (RT) and applied to standard radiographs of the proximal femur and to compare the results with bone mineral density (BMD). The study comprised 50 post-menopausal women (78.6 +/- 11.5 years of age), including 25 patients with hip fracture and 25 age-matched controls. We obtained lumbar and femoral BMD and standard femoral radiographs. In the radiographs we analysed trabecular patterns of the hip in a region-of-interest of 57 x 29 mm using the RT. From the histogram-representation of the RT, we extracted several characteristic parameters. By ROC and discriminant-analysis, we assessed the statistical power of both methods. For correct differentiation between fracture and non-fracture cases by femoral BMD, area-under-the-curve (AUC) was 0.78; AUC for the RT-based parameters ranged from 0.73 to 0.8. By combination of densitometric and textural information in a multivariate model the fracture status of 84% of subjects was predicted correctly, identification of fracture cases rose to 88%. Identification of fracture patients by RT applied to femoral radiographs was feasible and seemed to have a discriminative potential comparable to that of standard densitometry. In the future, the new method may provide an alternative to DXA or in conjunction with conventional densitometry may enhance the detection of patients with elevated risk of hip fracture.

  1. Hypovitaminosis D is associated with a reduction in upper and lower limb muscle strength and physical performance in post-menopausal women: a retrospective study.

    Science.gov (United States)

    Iolascon, Giovanni; de Sire, Alessandro; Calafiore, Dario; Moretti, Antimo; Gimigliano, Raffaele; Gimigliano, Francesca

    2015-10-01

    Elderly people experience a gradual loss of muscle strength and a reduction of serum levels of vitamin D and of vitamin D receptor expression in skeletal muscle cells. The aim of our study was to evaluate the association among serum levels of 25-hydroxy-vitamin D [25(OH)D3], muscle strength, and physical performance in post-menopausal women. In our retrospective case-control study, we analyzed data from medical records of post-menopausal women aged ≥ 50 years. We compared subjects with hypovitaminosis D [25(OH)D3 Strength Test (HGS) and Knee Extension Strength Test (KES) to evaluate upper and lower limb muscle strength, respectively; Short Physical Performance Battery (SPPB) and usual 4-m gait speed (4 MGS) to evaluate physical performance. We examined 80 patients (mean aged 65.92 ± 7.69 years): forty-six subjects with hypovitaminosis D (mean aged 66.09 ± 7.71 years) and 34 with normal levels of vitamin D (mean aged 65.71 ± 7.78 years). There was a statistically significant difference between hypovitaminosis D group and subjects with normal levels of vitamin D in HGS (12.13 ± 4.34 vs. 19.14 ± 5.59; p lower limb muscle strength and physical performance than subjects with normal levels of 25(OH)D3. Our results support the hypothesis that there is a significant positive association among serum 25(OH)D3 levels and upper and lower limb muscle functioning.

  2. The change in motivating factors influencing commencement, adherence and retention to a supervised resistance training programme in previously sedentary post-menopausal women: a prospective cohort study.

    Science.gov (United States)

    Viljoen, Janet Erica; Christie, Candice Jo-Anne

    2015-03-12

    Understanding motivators for exercise participation in post-menopausal women may impact retention to exercise programmes and inform intervention trial designs. The purpose of this investigation was to assess self-reported motivational factors influencing adherence and retention to a 24-week progressive resistance training programme. Post-menopausal females (n = 34) were passively recruited to undertake a 24-week progressive resistance training protocol, in small-group sessions, on three non-consecutive days of the week. Attendance was recorded by the researcher. Qualitative reports were sourced from the sample for four phases of the study: pre-study (prior to week 1), recruitment (week 1), during study (weeks 2 - 24), and post-intervention (beyond week 24). Responses were categorised according to ten descriptors: specific health index improvement, education, flexibility of time, social contact, conscience (loyalty to the researcher), wellness, weight management, organisation parameters (pertaining to the study programme) and enjoyment of the exercises. Of the initial sample, 76.5% (n = 26) met the specified ≥80% attendance criterion. The primary findings were that motivation to volunteer for the study was driven by a perceived need for a structured exercise programme (50% of respondents). A commitment to the researcher was the primary motivator for continued adherence to the study for 50% of participants. Social contact with other participants was cited by 60% of the sample as the primary reason for adherence for the full duration of 24 weeks. A desire to maintain the "wellness" derived from the programme was cited by 60% as a reason for continuing an exercise routine post-study. This study identified that routine and supervision initially attract women to exercise programmes, while social cohesion of the group setting contributes to retention over time. Understanding the changing nature of motivating factors may contribute to better overall adherence

  3. Stress at the place of work and cognitive functions among women performing intellectual work during peri- and post-menopausal period.

    Science.gov (United States)

    Gujski, Mariusz; Pinkas, Jarosław; Juńczyk, Tomasz; Pawełczak-Barszczowska, Adrianna; Raczkiewicz, Dorota; Owoc, Alfred; Bojar, Iwona

    2017-10-06

    The analysis of the relationship between stress at work and results of cognitive functions amongst women, at peri- and post-menopausal age, performing intellectual work. The study group included women, aged 45-66 years old, employed as intellectual workers. Research instruments were: the Montreal Cognitive Assessment; computer tests of the CNS Vital Signs; the Subjective Work Characteristics Questionnaire, and a questionnaire designed by the author. The results were statistically analyzed. Nearly a half of respondents experienced high stress at the place of work; 1/3 - on the average level, on a low level - every fifth. The largest number of respondents experienced stress caused by social contacts. Among a half of the women, stress was caused by the lack of awards at work, followed by the lack of support. Slightly fewer of them experienced stress caused by the feeling of psychological load related to the complexity of work or the feeling of uncertainty caused by the organization of work. Every third woman experienced stress due to the sense of responsibility or the lack of control. The smallest number experienced stress caused by physical arduousness, the sense of threat and unpleasant working conditions. The examined women obtained the best results with respect to simple attention, the worst results - with respect to the reaction time. The results concerning the remaining 9 cognitive functions were ranked in the middle of the aforementioned results. The intensity of stress at work and factors which caused this stress, negatively correlated with simple attention of women in the early peri-menopausal period, while positively correlating with the psychomotor and processing speed of women in the late peri-menopausal period. Among the post-menopausal women, negative correlations were observed between the majority of cognitive functions and the intensity of stress at work, and the majority of factors which caused this stress. Cognitive functions of the examined women

  4. The effects of water-based exercise in combination with blood flow restriction on strength and functional capacity in post-menopausal women.

    Science.gov (United States)

    Araújo, Joamira P; Neto, Gabriel R; Loenneke, Jeremy P; Bemben, Michael G; Laurentino, Gilberto C; Batista, Gilmário; Silva, Júlio C G; Freitas, Eduardo D S; Sousa, Maria S C

    2015-12-01

    Water-based exercise and low-intensity exercise in combination with blood flow restriction (BFR) are two methods that have independently been shown to improve muscle strength in those of advancing age. The objective of this study was to assess the long-term effect of water-based exercise in combination with BFR on maximum dynamic strength and functional capacity in post-menopausal women. Twenty-eight women underwent an 8-week water-based exercise program. The participants were randomly allocated to one of the three groups: (a) water exercise only, (b) water exercise + BFR, or (c) a non-exercise control group. Functional capacity (chair stand test, timed up and go test, gait speed, and dynamic balance) and strength testing were tested before and after the 8-week aquatic exercise program. The main findings were as follows: (1) water-based exercise in combination with BFR significantly increased the lower limb maximum strength which was not observed with water-based exercise alone and (2) water-based exercise, regardless of the application of BFR, increased functional performance measured by the timed up and go test over a control group. Although we used a healthy population in the current study, these findings may have important implications for those who may be contraindicated to using traditional resistance exercise. Future research should explore this promising modality in these clinical populations.

  5. Fermentation of calcium-fortified soya milk does not appear to enhance acute calcium absorption in osteopenic post-menopausal women.

    Science.gov (United States)

    Cheung, Anne Lise Tang Fook; Wilcox, Gisela; Walker, Karen Z; Shah, Nagendra P; Strauss, Boyd; Ashton, John F; Stojanovska, Lily

    2011-01-01

    Ageing women may choose to drink soya milk to reduce menopausal symptoms. As fermentation enriches soya milk with isoflavone aglycones, its beneficial qualities may improve. To reduce osteoporotic risk, however, soya milk must be Ca enriched, and it is not known how fermentation affects Ca bioavailability. A randomised crossover pilot study was undertaken to compare the Ca absorption of fortified soya milk with that of fermented and fortified soya milk in twelve Australian osteopenic post-menopausal women. The fortified soya milk was inoculated with Lactobacillus acidophilus American Type Culture Collection (ATCC) 4962 and fermented for 24 h at 37°C. Ca absorption from soya milk samples was measured using a single isotope radiocalcium method. Participants had a mean age of 54·8 (sd 12·3) years, with mean BMI of 26·5 (sd 5·5) kg/m2 and subnormal to normal serum 25-hydroxyvitamin D (mean 62·5 (sd 19·1) nmol/l). Participants consumed 185 kBq of 45Ca in 44 mg of Ca carrier. The mean fractional Ca absorption (α) from soya milk and fermented soya milk was 0·64 (sd 0·23) and 0·71 (sd 0·29), respectively, a difference not of statistical significance (P = 0·122). Although fermentation of soya milk may provide other health benefits, fermentation had little effect on acute Ca absorption.

  6. The Effects of Exercising in Different Natural Environments on Psycho-Physiological Outcomes in Post-Menopausal Women: A Simulation Study

    Directory of Open Access Journals (Sweden)

    Mathew P. White

    2015-09-01

    Full Text Available The current study examined potential psycho-physiological benefits from exercising in simulated natural environments among a sample of post-menopausal women using a laboratory based protocol. Participants cycled on a stationary exercise bike for 15 min while facing either a blank wall (Control or while watching one of three videos: Urban (Grey, Countryside (Green, Coast (Blue. Blood pressure, heart rate and affective responses were measured pre-post. Heart rate, affect, perceived exertion and time perception were also measured at 5, 10 and 15 min during exercise. Experience evaluation was measured at the end. Replicating most earlier findings, affective, but not physiological, outcomes were more positive for exercise in the simulated Green and, for the first time, Blue environment, compared to Control. Moreover, only the simulated Blue environment was associated with shorter perceived exercise duration than Control and participants were most willing to repeat exercise in the Blue setting. The current research extended earlier work by exploring the effects of “blue exercise” and by using a demographic with relatively low average levels of physical activity. That this sample of postmenopausal women were most willing to repeat a bout of exercise in a simulated Blue environment may be important for physical activity promotion in this cohort.

  7. The Effects of Exercising in Different Natural Environments on Psycho-Physiological Outcomes in Post-Menopausal Women: A Simulation Study

    Science.gov (United States)

    White, Mathew P.; Pahl, Sabine; Ashbullby, Katherine J.; Burton, Francesca; Depledge, Michael H.

    2015-01-01

    The current study examined potential psycho-physiological benefits from exercising in simulated natural environments among a sample of post-menopausal women using a laboratory based protocol. Participants cycled on a stationary exercise bike for 15 min while facing either a blank wall (Control) or while watching one of three videos: Urban (Grey), Countryside (Green), Coast (Blue). Blood pressure, heart rate and affective responses were measured pre-post. Heart rate, affect, perceived exertion and time perception were also measured at 5, 10 and 15 min during exercise. Experience evaluation was measured at the end. Replicating most earlier findings, affective, but not physiological, outcomes were more positive for exercise in the simulated Green and, for the first time, Blue environment, compared to Control. Moreover, only the simulated Blue environment was associated with shorter perceived exercise duration than Control and participants were most willing to repeat exercise in the Blue setting. The current research extended earlier work by exploring the effects of “blue exercise” and by using a demographic with relatively low average levels of physical activity. That this sample of postmenopausal women were most willing to repeat a bout of exercise in a simulated Blue environment may be important for physical activity promotion in this cohort. PMID:26404351

  8. Wrinkle reduction in post-menopausal women consuming a novel oral supplement: a double-blind placebo-controlled randomized study.

    Science.gov (United States)

    Jenkins, G; Wainwright, L J; Holland, R; Barrett, K E; Casey, J

    2014-02-01

    The maintenance of youthful skin appearance is strongly desired by a large proportion of the world's population. The aim of the present study was therefore to evaluate the effect on skin wrinkling, of a combination of ingredients reported to influence key factors involved in skin ageing, namely inflammation, collagen synthesis and oxidative/UV stress. A supplemented drink was developed containing soy isoflavones, lycopene, vitamin C and vitamin E and given to post-menopausal women with a capsule containing fish oil. We have performed a double-blind randomized controlled human clinical study to assess whether this cocktail of dietary ingredients can significantly improve the appearance of facial wrinkles. We have shown that this unique combination of micronutrients can significantly reduce the depth of facial wrinkles and that this improvement is associated with increased deposition of new collagen fibres in the dermis. This study demonstrates that consumption of a mixture of soy isoflavones, lycopene, vitamin C, vitamin E and fish oil is able to induce a clinically measureable improvement in the depth of facial wrinkles following long-term use. We have also shown, for the first time with an oral product, that the improvement is associated with increased deposition of new collagen fibres in the dermis. © 2013 Unilever UK Central Resources Limited.

  9. Alterations in Circulating miRNA Levels following Early-Stage Estrogen Receptor-Positive Breast Cancer Resection in Post-Menopausal Women

    DEFF Research Database (Denmark)

    Kodahl, Annette R; Zeuthen, Pernille; Binder, Harald

    2014-01-01

    INTRODUCTION: Circulating microRNAs (miRNAs) exhibit remarkable stability and may serve as biomarkers in several clinical cancer settings. The aim of this study was to investigate changes in the levels of specific circulating miRNA following breast cancer surgery and evaluate whether these altera...... and could potentially be used to monitor whether all cancer cells have been removed at surgery and/or, subsequently, whether the patients develop recurrence.......INTRODUCTION: Circulating microRNAs (miRNAs) exhibit remarkable stability and may serve as biomarkers in several clinical cancer settings. The aim of this study was to investigate changes in the levels of specific circulating miRNA following breast cancer surgery and evaluate whether...... these alterations were also observed in an independent data set. METHODS: Global miRNA analysis was performed on prospectively collected serum samples from 24 post-menopausal women with estrogen receptor-positive early-stage breast cancer before surgery and 3 weeks after tumor resection using global LNA...

  10. CORRELATION OF PHYSICAL ACTIVITY LEVEL WITH BONE MINERAL DENSITY, CARDIO-RESPIRATORY FITNESS AND BODY COMPOSITION IN POST-MENOPAUSAL WOMEN

    Directory of Open Access Journals (Sweden)

    Niyati N Khona

    2017-09-01

    Full Text Available Background: Due to the hormonal changes in postmenopausal women they are prone for many complications like increased CVD risk factors, osteoporosis, obesity, mood swings and urinary incontinence. Physical inactivity in postmenopausal women leads to higher risk of developing CVD and osteoporosis. The objective was to find out the correlation of physical activity level with BMD, cardio-respiratory fitness and body composition in post-menopausal women Methods: 42 postmenopausal women were included. A detailed clinical evaluation with physical activity level (IPAQ-METS-mins/week, , BMD ( T-Scores, body composition (BMI, waist circumference, BIA & Skin fold calliper for fat %, cardio-respiratory fitness was measured by Balke protocol and VO2peak (ml/kg/min is estimated. Correlation of physical activity level with BMD, cardio-respiratory fitness and body composition were analysed using “Pearson’s product moment correlation co-efficient and Spearman’s rho.” Results: Spearman’s rank correlation rho for IPAQ with VO2 peak was 0.420,BMI was -0.388 and visceral fat was -0.384 indicating moderate positive correlation between IPAQ and cardio-respiratory fitness and weak negative correlation between IPAQ and BMI and visceral fat. Pearson’s product moment correlation coefficient of IPAQ with BMD was 0.147, body fat was -0.234 and waist circumference was -0.256 indicating no correlation. P value was significant for correlation of IPAQ with CRF (0.006, BMI (0.011 and Visceral fat (0.012. Conclusion: There is moderate positive correlation between IPAQ and cardio-respiratory fitness, weak negative correlation between IPAQ and BMI and visceral fat and no correlation between IPAQ and BMD, body fat and waist circumference

  11. Opinion of South African pre- and post-menopausal women on the potential menopause-related health benefits of soy and soy products

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    Magdalena JC Bosman

    2008-11-01

    Full Text Available The increased use of alternative treatment for menopausal symptoms is mainly due to women’s changing opinions of conventional hormone replacement therapy (HRT. The objective of this study was to assess the opinion of pre and post-menopausal South African women regarding the potential menopause-related health benefits of soy. The sample used for the study was a sub-dataset of 825 respondents, which included only pre- and post-menopausal women that had heard of soy before, selected from a representative sample of the adult South African metropolitan and rural populations. A structured questionnaire was used. Neither age nor racial groups differed practically significantly in opinion regarding any of the various statements. The study also shows that a practically significant lower proportion of women in the sub-population across both age and race groups had a positive opinion on the health benefits of soy as an alternative to HRT and reliever of menopausal symptoms than those who acknowledged its benefit for preventing cardiovascular disease and osteoporosis. Practically significantly more women who used soy than women who never used soy agreed that soy keeps bones strong. In addition, more women who were of opinion that soy has few or no health benefits disagreed that soy could be used as an alternative to HRT compared to women who held a positive opinion. Opsomming Die toenemende gebruik van alternatiewe behandelings vir menopousale simptome kan aan vroue se veranderende opinies oor konvensionele hormoonvervangingsterapie (HVT toegeskryf word. Die doel van hierdie studie was om pre- en post- menopousale Suid-Afrikaanse vroue se opinie aangaande die potensiële menopouseverwante gesondheids-voordele van soja te bepaal. Die steekproef vir die studie het uit ‘n subdatastel bestaan van 825 vroue in hul pre- en post-menopousale stadium wat al voorheen van soja gehoor het, en is vanuit ‘n verteenwoordigende steekproef van die volwasse Suid

  12. Age of Menopause and Fracture Risk in Post-Menopausal Women Randomized to Calcium + Vitamin D, Hormone Therapy, or the combination: Results from the Women’s Health Initiative Clinical Trials

    Science.gov (United States)

    Sullivan, Shannon D.; Lehman, Amy; Nathan, Nisha K.; Thomson, Cynthia A.; Howard, Barbara V.

    2016-01-01

    OBJECTIVE We previously reported that in the absence of hormone therapy (HT) or calcium/vitamin D (Ca/D) supplementation, earlier menopause age was associated with decreased bone mineral density (BMD) and increased fracture risk in healthy post-menopausal women. Treatment with HT and Ca/D are protective against fractures after menopause. In this analysis, we asked if age of menopause onset alters fracture risk in healthy post-menopausal women receiving HT, Ca/Vit D, or the combination. METHODS Hazard ratios (HR) for any fracture among 21,711 healthy post-menopausal women enrolled in the Women’s Health Initiative Clinical Trial (WHI-CT), who were treated with HT, Ca/Vit D, or HT + Ca/D, and who reported age of non-surgical menopause of menopause menopause 40-49 or ≥50, regardless of treatment intervention [HR (95% CI): menopause menopause menopause age (menopause ages. The effect of menopause age on fracture risk was not altered by any of the treatment interventions (HT, Ca/D, HT+Ca/D), suggesting that early age of menopause is an independent contributor to postmenopausal fracture risk. PMID:27801706

  13. A systems biology approach investigating the effect of probiotics on the vaginal microbiome and host responses in a double blind, placebo-controlled clinical trial of post-menopausal women.

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    Jordan E Bisanz

    Full Text Available A lactobacilli dominated microbiota in most pre and post-menopausal women is an indicator of vaginal health. The objective of this double blinded, placebo-controlled crossover study was to evaluate in 14 post-menopausal women with an intermediate Nugent score, the effect of 3 days of vaginal administration of probiotic L. rhamnosus GR-1 and L. reuteri RC-14 (2.5×109 CFU each on the microbiota and host response. The probiotic treatment did not result in an improved Nugent score when compared to when placebo. Analysis using 16S rRNA sequencing and metabolomics profiling revealed that the relative abundance of Lactobacillus was increased following probiotic administration as compared to placebo, which was weakly associated with an increase in lactate levels. A decrease in Atopobium was also observed. Analysis of host responses by microarray showed the probiotics had an immune-modulatory response including effects on pattern recognition receptors such as TLR2 while also affecting epithelial barrier function. This is the first study to use an interactomic approach for the study of vaginal probiotic administration in post-menopausal women. It shows that in some cases multifaceted approaches are required to detect the subtle molecular changes induced by the host to instillation of probiotic strains.ClinicalTrials.gov NCT02139839.

  14. THE CALCIOTROPIC HORMONE RESPONSE TO OMEGA-3 SUPPLE-MENTATION DURING LONG-TERM WEIGHT-BEARING EXERCISE TRAINING IN POST MENOPAUSAL WOMEN

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    Bakhtiar Tartibian

    2010-06-01

    Full Text Available The purpose of this study was to examine the effects of ingestion of omega-3 (n-3 and aerobic exercise intervention on the calcium regulating hormones in healthy postmenopausal women. To this end, 56 healthy sedentary postmenopausal women with mean age 57.7 ± 3.5 yrs participated in this study. Participants were randomly divided into exercise plus supple-ment (E+S; n = 14, exercise (E; n = 14, supplement (S; n = 14 and control (Con, n = 14 groups. The subjects in E+S and E groups performed aerobic exercise training (walking and jog-ging up to 65% of exercise HRmax, three times a week for 16 weeks. Subjects in E+S and S groups were asked to consume 1000 mg/d omega-3 for 16 weeks. The blood ionized Calcium (Ca+2, Parathyroid hormone (PTH, estrogen and Calcitonin (CT were measured before and after 16 weeks of exercise training. Results indicated that consuming 1000 mg·day-1 omega-3 during 16 weeks and or the aerobic exercise, significantly increased CT (p = 0.001 in E+S, E and S groups and significantly decreased PTH (p = 0.001 levels in E+S and E groups, also significantly increased estrogen (p = 0.024 levels in E+S and E groups, but had no significant effects on blood Ca+2 (p = 0.619 levels. The results of present study demonstrate that omega-3 in combination with regular aerobic exercise training have significant effects on serum CT, estrogen and PTH in non-athletic post-menopausal women, suggesting that participating in moderate intensity weight-bearing exercise and incorporating sources of omega-3 in the diet a possible intervention to help slow the loss of bone that occurs following menopause

  15. Comparison of multi- and single-frequency bioelectrical impedance analysis with dual-energy X-ray absorptiometry for assessment of body composition in post-menopausal women: effects of body mass index and accelerometer-determined physical activity.

    Science.gov (United States)

    Gába, A; Kapuš, O; Cuberek, R; Botek, M

    2015-08-01

    Bioelectric impedance analysis (BIA) is commonly used in research to assess body composition. However, studies that validate the accuracy of BIA exclusively in post-menopausal women are lacking. The main purpose of the present study was to evaluate the agreement of multi-frequency (MF)-BIA and single-frequency (SF)-BIA with dual-energy X-ray absorptiometry (DXA) in the estimation of fat mass (FM) and fat-free mass (FFM) among post-menopausal women with variation in body mass index (BMI) and physical activity (PA). FM and FFM were estimated by BIA and DXA in 146 post-menopausal women with a mean (SD) age of 62.8 (5.2) years. PA was determined by an accelerometer. The mean (SD) difference between MF-BIA and DXA was -1.8 (1.8) kg (P = 0.08) and 1.3 (1.8) kg (P = 0.01) for FM and FFM, respectively. SF-BIA provided a significantly lower estimate of FM [-2.0 (2.2) kg; P = 0.04] and a higher estimate of FFM [1.8 (2.4) kg; P obese and insufficiently active subjects. In other BMI and PA groups, both BIA devices showed a similar deviation from DXA. BIA tends to underestimate FM and overestimate FFM relative to DXA. MF-BIA appears to be a more appropriate method for the assessment of body composition than SF-BIA in post-menopausal woman with BMI >30 kg/m(2) and in those who are insufficiently active. © 2014 The British Dietetic Association Ltd.

  16. Association between the serum concentration of triiodothyronine with components of metabolic syndrome, cardiovascular risk, and diet in euthyroid post-menopausal women without and with metabolic syndrome.

    Science.gov (United States)

    Luna-Vazquez, Fabiola; Cruz-Lumbreras, Rosalía; Rodríguez-Castelán, Julia; Cervantes-Rodríguez, Margarita; Rodríguez-Antolín, Jorge; Arroyo-Helguera, Omar; Castelán, Francisco; Martínez-Gómez, Margarita; Cuevas, Estela

    2014-01-01

    To determine the association between the serum concentration of triiodothyronine (T3) with components of metabolic syndrome (MetS), cardiovascular risk (CVR), and diet in euthyroid post-menopausal women without and with MetS. A cross-sectional study was performed in 120 voluntary women of an indigenous population from Tlaxcala-México. Euthyroid status was assessed measuring the serum concentration of thyrotropin (TSH) and thyroid hormones, while that of estradiol was measured to confirm the postmenopausal condition. MetS was diagnosed using the American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement (AHA/NHLBI) criterion. Estimation of CVR was calculated based on the Framingham scale. Diet components were evaluated based on survey applications. Correlations, logistic regression analyses, ANOVA or Kruskall-Wallis, and chi-square tests were used to determine significant differences (P ≤ 0.05) between women without MetS and women with MetS having different serum concentrations of T3. Triiodothyronine was positively correlated with insulin but negatively correlated with glucose, high-density lipoprotein cholesterol (HDL-C), and CVR. Compared to women without MetS, women with MetS and low-normal T3 concentration showed a high risk for hyperglycemia and moderate/high risk for CVR. In contrast, a high-normal T3 concentration increased the risk to have a big waist circumference, a high concentration of HDL-C, and insulin resistance. Diet analysis showed a high grade of malnutrition in women from all groups. The intake of calories was positively affected by the T3 concentration, albeit it did not affect the extent of malnutrition. In contrast to concentrations of TSH, total thyroxin (T4), and free T4, the concentration of serum T3 was strongly correlated with cardio-metabolic variables in euthyroid postmenopausal women. In comparison to women without MetS, a high-normal serum concentration of T3 in women with MetS is positively

  17. Quality of life among post-menopausal women due to oxidative stress boosted by dysthymia and anxiety.

    Science.gov (United States)

    Sánchez-Rodríguez, Martha A; Castrejón-Delgado, Lizett; Zacarías-Flores, Mariano; Arronte-Rosales, Alicia; Mendoza-Núñez, Víctor Manuel

    2017-01-03

    Menopause is the onset of aging in women. During this process, some women experience physical changes that may impact upon their psychological and social status, also affecting their quality of life. Furthermore, several psychological changes following menopause have been shown to act as pro-oxidant, but the association between the psychological status that modify the quality of life and oxidative stress in postmenopausal women is still unclear. The aim of this study was to determinate the relationship between oxidative stress with psychological disturbances, low self-esteem, depressive mood and anxiety, and quality of life in the postmenopausal women. We carried out a cross-sectional study with101 premenopausal and 101 postmenopausal women from Mexico City. As markers of oxidative stress we measured plasma lipoperoxide levels, erythrocyte superoxide dismutase and glutathione peroxidase activities, and total antioxidant status. We calculate a stress score as global oxidative stress status, with cut-off values for each parameter; this score range from 0 to 6, representing the severity of markers modifications. All the women were rated using the Coopersmith Self-Esteem Inventory, the Zung Self-Rating Anxiety and the Zung Self-Rating Depression Scales, and the WHO Quality of Life-brief. The postmenopausal women with low quality of life in the WHO Quality of Life-brief and their subscales had higher stress score compared with premenopausal women with high quality of life (p Life-brief scores (r = -0.266, p Life-brief, after adjusted for pro-oxidant factors. Zung Self-Rating Anxiety and Zung Self-Rating Depression Scales scores also contribute to increase lipoperoxides levels, but not significant. Our findings suggest that oxidative stress is increased in postmenopausal women with psychological disturbances and low quality of life.

  18. Comparison of bone mineral density among pre- and post-menopausal women with and without chronic generalized periodontitis

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    Priyadarshini Ramasubramanian Svedha

    2017-01-01

    Full Text Available Background: There have been a very limited number of studies regarding the assessment of bone mineral density (BMD using dual energy X-ray absorptiometry scan. Hence, the purpose of the study was to assess the relationship between BMD and periodontal health in three different study groups. Materials and Methods: The study comprised of thirty female individuals who were categorized into three groups: ten premenopausal women with healthy periodontium (Group A, ten premenopausal women with generalized chronic periodontitis (Group B, and ten postmenopausal women with generalized chronic periodontitis (Group C. Number of teeth, plaque index, probing depth, clinical attachment level, interproximal alveolar bone loss, T-score for dual femur and posteroanterior (PA spine, and BMD for dual femur and PA spine of each individual were recorded in all the three groups. Results: The BMD and T-score of dual femur and PA spine were found to be low in Group C when compared to Group A and B which was statistically significant. Conclusion: Postmenopausal women with generalized chronic periodontitis (Group C exhibited severe periodontal destruction with less BMD. Hence, it is suggested that periodontitis may be a risk indicator for osteoporosis in postmenopausal women and vice versa.

  19. Effects of a Pilates exercise program on muscle strength, postural control and body composition: results from a pilot study in a group of post-menopausal women.

    Science.gov (United States)

    Bergamin, M; Gobbo, S; Bullo, V; Zanotto, T; Vendramin, B; Duregon, F; Cugusi, L; Camozzi, V; Zaccaria, M; Neunhaeuserer, D; Ermolao, A

    2015-12-01

    Participation in exercise programs is heartily recommended for older adults since the level of physical fitness directly influences functional independence. The aim of this present study was to investigate the effects of supervised Pilates exercise training on the physical function, hypothesizing that a period of Pilates exercise training (PET) can increase overall muscle strength, body composition, and balance, during single and dual-task conditions, in a group of post-menopausal women. Twenty-five subjects, aged 59 to 66 years old, were recruited. Eligible participants were assessed prior and after 3 months of PET performed twice per week. Muscular strength was evaluated with handgrip strength (HGS) test, 30-s chair sit-to-stand test (30CST), and abdominal strength (AST) test. Postural control and dual-task performance were measured through a stabilometric platform while dynamic balance with 8 ft up and go test. Finally, body composition was assessed by means of dual-energy X-ray absorptiometry. Statistically significant improvements were detected on HGS (+8.22%), 30CST (+23.41%), 8 ft up and go test (-5.95%), AST (+30.81%), medio-lateral oscillations in open eyes and dual-task condition (-22.03% and -10.37%). Pilates was effective in increasing upper body, lower body, and abdominal muscle strength. No changes on body composition were detected. Results on this investigation indicated also that 12-week of mat Pilates is not sufficient to determine a clinical meaningful improvement on static balance in single and dual-task conditions.

  20. The effect of Korean pine nut oil on in vitro CCK release, on appetite sensations and on gut hormones in post-menopausal overweight women

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    Hendriks Henk FJ

    2008-03-01

    Full Text Available Abstract Appetite suppressants may be one strategy in the fight against obesity. This study evaluated whether Korean pine nut free fatty acids (FFA and triglycerides (TG work as an appetite suppressant. Korean pine nut FFA were evaluated in STC-1 cell culture for their ability to increase cholecystokinin (CCK-8 secretion vs. several other dietary fatty acids from Italian stone pine nut fatty acids, oleic acid, linoleic acid, alpha-linolenic acid, and capric acid used as a control. At 50 μM concentration, Korean pine nut FFA produced the greatest amount of CCK-8 release (493 pg/ml relative to the other fatty acids and control (46 pg/ml. A randomized, placebo-controlled, double-blind cross-over trial including 18 overweight post-menopausal women was performed. Subjects received capsules with 3 g Korean pine (Pinus koraiensis nut FFA, 3 g pine nut TG or 3 g placebo (olive oil in combination with a light breakfast. At 0, 30, 60, 90, 120, 180 and 240 minutes the gut hormones cholecystokinin (CCK-8, glucagon like peptide-1 (GLP-1, peptide YY (PYY and ghrelin, and appetite sensations were measured. A wash-out period of one week separated each intervention day. CCK-8 was higher 30 min after pine nut FFA and 60 min after pine nut TG when compared to placebo (p This study suggests that Korean pine nut may work as an appetite suppressant through an increasing effect on satiety hormones and a reduced prospective food intake.

  1. A comparative study on BMD of lumbar spine and proximal femur in post-menopausal women using dual energy X-ray absorptiometry

    International Nuclear Information System (INIS)

    Yoon, Han Sik; Mo, Eun Hee

    1999-01-01

    Osteoporosis, which causes mainly fracture of the spine, proximal femur and distal radius by minimal trauma, is a major public health problem and its prevalence is steadily increasing in Korea according to the development of public health care. There are reliable methods for diagnosis based on bone densitometry. Early detection and intervention are important for reducing the incidence of fractures. A consensus definition of osteoporosis, based on bone density measurement, has been developed by the World Health Organization(WHO). In this study, bone mineral density(BMD) was measured by dual energy x-ray absorptiometry(DEXA) at the proximal femur and lumbar spine in 132 post-menopausal women. The purpose of this study is to find influential factors on the BMD of the proximal femur and the lumbar spine and to analyze correlation between BMD and the problematic factors. We obtained the following results : 1. Mean BMD score, T-score and Z-score of the proximal femur were 0.81(g/cm 2 ), -2.45(S.D.) and -2.09(S.D.) respectively and in the lumber spine were 0.83(g/cm 2 ), -2.02(S.D.), -2.43(S.D.) respectively. 2. In correlation analysis between BMD and many factors, correlation coefficients were -0.467, 0.212, -0.321 and 0.241 in age, height, duration after menopause respectively. BMI and the residuals were comparatively small. 3. Correlation coefficients to age matched BMD, in height and body weight were 0.222 and 0.241, in age and duration after menopause were -0.268, -0.282. 4. The fracture threshold of proximal femur BMD to the 90th percentile was 0.845(g/cm 2 ). 5. At the result of multiple regression analysis, age, body weight, BMI(kg/m 2 ) and duration after menopause described as significant variables

  2. Fractal dimension analysis in digital periapical radiographs: A diagnostic indicator of osteoporosis in post-menopausal women

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    Mathivanan Kavitha

    2017-01-01

    Full Text Available Objectives: To assess the alveolar bone density by fractal dimension (FD analysis in radiovisiograph of postmenopausal women of mandibular posterior region and to correlate FD values with t-scores of quantitative ultrasound of the calcaneus bone. Materials and Methods: This study, approved by the institutional review board, included 40 participants, aged 45–60 years divided into two groups. Twenty postmenopausal women with osteoporosis comprised group 1, and 20 postmenopausal women without osteoporosis comprised group 2 based on bone mineral density assessment of ultrasound of the calcaneus bone. Digital dental radiograph of mandibular first molar were obtained and used for assessing alveolar bone density by FD analysis and were correlated with t-scores of ultrasound of calcaneus bone. Results: The mean FD values were evaluated using SPSS 14 version software, and were found to be 1.738 and 1.867 for group 1 and group 2, respectively, which was statistically significant (P 0.05. Conclusion: FD analysis using direct digital periapical radiographs is a novel method, which can be used for early diagnosis of osteoporosis in the alveolar bone.

  3. Acylated Ghrelin Level Response to Daily Step in the Post-Menopause Active and Sedentary Elderly Women

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    Farzad Nazem

    2014-07-01

    Full Text Available Objectives: Plasmatic total ghrelin levels (ie, acylate & unacylated isoformes are changeable during malnutrition, starvation regime, exercise bouts, obesity and hyperglycemia conditions. Studies have reported increases, decreases or no change in total ghrelin concentrations as a resultsresults of exercise. WalkingSince walking is used as a movement current pattern with a different lifestyle conditions, especially in several social jobs activities of daily livings of the middle-aged and elderly, the aim of the present study is to evaluate whether therelationship betweenthe number of step per day steps per day andwith acylated ghrelin of menopausal women is related to different life styles.as well, the effects of physical activity volume on this peptide hormone. Methods & Materials: Daily step volumes voluntarily were measured in the health postmenopausal women (n=40 by the electronic pedometer. Subjects (aged 55.9±4.6 divided by as active group (AG=20 and sedentary group (SG=20. Results: Daily step average in the AG (8022±2659 step/day significantly was higher than SG (3450±913 step/day (P<0.001. Acylated ghrelin and Insulin concentrations were markedly not different in AG (195.4±131 pg/ml, 9.2±3.03 μU/ml respectively and SG (165.4±73 pg/ml, 11.5±4.7 μU/ml respectively as well, step per day were not associated with these hormones. There was a significant difference in body composition variables (BMI, %BF, WHR among 2 groups and significant inverse correlations were found between activity and body composition variables in women. Conclusion: According to the results, it is recommended that trainers, organizations and institutions that deal with the elderly, use the cycling and walking exercises, especially walking and jogging to reduce the risk of further problem in these people.

  4. Is handgrip strength normalized to body weight a useful tool to identify dynapenia and functional incapacity in post-menopausal women?

    Directory of Open Access Journals (Sweden)

    Maude Dulac

    Full Text Available ABSTRACT Objective To investigate whether handgrip strength normalized to body weight could be a useful clinical tool to identify dynapenia and assess functional capacity in post-menopausal women. Method A total of 136 postmenopausal women were recruited. Body composition (Dual Energy X-ray Absorptiometry [DEXA], Bio-electrical Impedence Analysis [BIA], grip strength (dynamometer and functional capacity (senior fitness tests were evaluated. Dynapenia was established according to a handgrip strength index (handgrip strength divided by body weight (BW in Kg/KgBW obtained from a reference population of young women: Type I dynapenic (<0.44 kg/KgBW and type II dynapenic (<0.35 kg/KgBW. Results The results show a positive correlation between handgrip strength index (in kg/KgBW and alternate-step test (r=0.30, p<0.001, chair-stand test (r=0.25, p<0.005 and one-leg stance test (r=0.335, p<0.001. The results also showed a significant difference in non-dynapenic compared to type I dynapenic and type II dynapenic for the chair-stand test (Non-dynapenic: 12.0±3.0; Type I: 11.7±2.5; Type II: 10.3±3.0 (p=0.037 and p=0.005, respectively and the one-leg stance test (Non-dynapenic: 54.2±14.2; Type I: 43.8±21.4; Type II: 35.0±21.8 (p=0.030 and p=0.004, respectively. Finally, a significant difference was observed between type II dynapenic and non-dynapenic for the chair-stand test (p=0.032, but not with type I dynapenic. Conclusion The results showed that handgrip strength was positively correlated with functional capacity. In addition, non-dynapenic women displayed a better functional status when compared to type I and type II dynapenic women. Thus, the determination of the handgrip strength thresholds could be an accessible and affordable clinical tool to identify people at risk of autonomy loss.

  5. Differential genetic basis for pre-menopausal and post-menopausal salt-sensitive hypertension.

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    Victoria L M Herrera

    Full Text Available Essential hypertension affects 75% of post-menopausal women in the United States causing greater cardiovascular complications compared with age-matched men and pre-menopausal women. Hormone replacement and current anti-hypertensive therapies do not correct this post-menopausal increased risk suggesting a distinct pathogenic framework. We investigated the hypothesis that distinct genetic determinants might underlie susceptibility to salt sensitive hypertension in pre-menopausal and post-menopausal states. To determine whether distinct genetic loci contribute to post-menopausal salt-sensitive hypertension, we performed a genome-wide scan for quantitative trait loci (QTLs affecting blood pressure (BP in 16-month old post-menopausal F2 (Dahl S×R-intercross female rats characterized for blood pressure by radiotelemetry. Given identical environments and high salt challenge, post-menopausal BP levels were significantly higher than observed in pre-menopausal (post-menopausal versus pre-menopausal SBP, P<0.0001 and ovariectomized (post-menopausal versus ovariectomized SBP, P<0.001 F2-intercross female rats. We detected four significant to highly significant BP-QTLs (BP-pm1 on chromosome 13, LOD 3.78; BP-pm2 on chromosome 11, LOD 2.76; BP-pm3 on chromosome 2, LOD 2.61; BP-pm4 on chromosome 4, LOD 2.50 and two suggestive BP-QTLs (BP-pm5 on chromosome 15, LOD 2.37; BP-f1 on chromosome 5, LOD 1.65, four of which (BP-pm2, BP-pm3, BP-pm4, BP-pm5 were unique to this post-menopausal cohort. These data demonstrate distinct polygenic susceptibility underlying post-menopausal salt-sensitive hypertension providing a pathway towards the identification of mechanism-based therapy for post-menopausal hypertension and ensuing target-organ complications.

  6. Intravaginally applied oxytocin improves post-menopausal vaginal atrophy.

    Science.gov (United States)

    Al-Saqi, Shahla H; Uvnäs-Moberg, Kerstin; Jonasson, Aino F

    2015-09-01

    To explore the efficacy of local oxytocin for the treatment of post-menopausal vaginal atrophy. Double-blinded randomised controlled trial. Healthy post-menopausal women in Stockholm, Sweden. Sixty four post-menopausal women between February and June 2012 at the Karolinska University Hospital Huddinge/Sweden. The efficacy of oxytocin for treatment of vaginal atrophy after seven weeks and cytological evaluation. The percentage of superficial cells in the vaginal smears and the maturation values were significantly increased after seven weeks of treatment with vagitocin 400 IU (p = 0.0288 and p = 0.0002, respectively). The vaginal pH decreased significantly after seven weeks of treatment with vagitocin 100 IU (p = 0.02). The scores of vaginal atrophy, according to the histological evaluation, were significantly reduced after administration of vagitocin 100 IU (p = 0.03). The thickness of the endometrium did not differ between the treatment and placebo groups after seven weeks of treatment. The symptom experienced as the most bothersome was significantly reduced after seven weeks of treatment in the women receiving vagitocin 400 IU compared to women in the placebo group (p = 0.0089). Treatment with intravaginally applied oxytocin could be an alternative to local estrogen treatment in women with post-menopausal vaginal atrophy. © The Author(s) 2015.

  7. Histopathological findings of Post-Menopausal bleeding in ...

    African Journals Online (AJOL)

    Background: Postmenopausal bleeding is an alarming sign that may be associated with uterine malignancy. In recent years about 60% of women with post menopausal bleeding are said to have no organic cause in developed countries. There is no data concerning about this issue in Ethiopia. Objective: To determine ...

  8. Qualitative cross-cultural exploration of vaginal bleeding/spotting symptoms and impacts associated with hormone therapy in post-menopausal women to inform the development of new patient-reported measurement tools.

    Science.gov (United States)

    Arbuckle, Rob; Humphrey, Louise; Abraham, Lucy; Dennerstein, Lorraine; Simon, James A; Mirkin, Sebastian; Bonner, Nicola; Walmsley, Steven; Tatlock, Sophi; Symonds, Tara

    2014-07-01

    To understand the vaginal bleeding/spotting experiences of postmenopausal (PM) women taking estrogen plus progestin therapies (EPT) and develop measures to assess these symptoms and their impact on women's daily lives in four countries. (1) Concept elicitation interviews were conducted with PM women in the US (n=14), Italy (n=15), Mexico (n=15) and China (n=15) to explore vaginal bleeding/spotting symptoms associated with EPT. The Post-Menopausal Bleeding Questionnaire (PMBQ) was also debriefed to evaluate understanding and comprehensiveness. (2) Based on concept elicitation, a single item electronic daily diary was developed and the PMBQ modified to form a 12-item impact measure. (3) The measures were pilot-tested and then cognitively debriefed with US women receiving EPT. All qualitative data was subject to thematic analysis. The Vaginal Bleeding/Spotting Daily Diary, (VBS-DD) and Post-Menopausal Bleeding Impact Questionnaire (PMBIQ) were developed in this study. Concept elicitation identified vaginal bleeding and spotting as important symptoms for women taking EPT, impacting their emotional wellbeing, social life, ability to move freely, clothing and sexual activity. Based on pilot testing and cognitive debriefing, women demonstrated good understanding of the VBS-DD and the PMBQ was reduced to 10 items due to conceptual redundancy. Women taking EPT in the US, China, Mexico and Italy reported vaginal bleeding/spotting symptoms that have a detrimental impact on their quality of life. Two new measures were developed to assess the severity and impact of vaginal bleeding/spotting specific to EPT. This work highlights the need for EPT-related symptoms to be a part of treatment decision-making. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  9. Risk of chronic liver disease in post-menopausal women due to body mass index, alcohol and their interaction: a prospective nested cohort study within the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS

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    Paul M Trembling

    2017-06-01

    Full Text Available Abstract Background We investigated the risk of chronic liver disease (CLD due to alcohol consumption and body mass index (BMI and the effects of their interaction in a prospective cohort study of women recruited to the UKCTOCS trial. Methods 95,126 post-menopausal women without documented CLD were stratified into 12 groups defined by combinations of BMI (normal, overweight, obese and alcohol consumption (none, <1–15, 16–20 and ≥21 units/week, and followed for an average of 5.1 years. Hazard ratios (HR were calculated for incident liver-related events (LRE. Results First LREs were reported in 325 (0.34% participants. Compared to women with normal BMI, HR = 1.44 (95% CI; 1.10–1.87 in the overweight group and HR = 2.25 (95% CI; 1.70–2.97 in the obese group, adjusted for alcohol and potential confounders. Compared to those abstinent from alcohol, HR = 0.70 (95% CI; 0.55–0.88 for <1–15 units/week, 0.93 (95% CI; 0.50–1.73 for 16–20 units/week and 1.82 (95% CI; 0.97–3.39 for ≥21 units/week adjusted for BMI and potential confounders. Compared to women with normal BMI drinking no alcohol, HR for LRE in obese women consuming ≥21 units/week was 2.86 (95% CI; 0.67–12.42, 1.58 (95% CI; 0.96–2.61 for obese women drinking <1–15 units/week and 1.93 (95% CI; 0.66–5.62 in those with normal BMI consuming ≥21 units/week after adjustment for potential confounders. We found no significant interaction between BMI and alcohol. Conclusion High BMI and alcohol consumption and abstinence are risk factors for CLD in post-menopausal women. However, BMI and alcohol do not demonstrate significant interaction in this group. Trial registration UKCTOCS is registered as an International Standard Randomised Controlled Trial, number ISRCTN22488978 . Registered 06/04/2000.

  10. Fatores associados à obesidade global e à obesidade abdominal em mulheres na pós-menopausa Factors associated with body and abdominal obesity in post-menopausal women

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    Ana Paula França

    2008-03-01

    Full Text Available OBJETIVOS: avaliar a prevalência de obesidade global e obesidade abdominal, em mulheres pós-menopausa, segundo o grau de instrução, nível de atividade física, uso de terapia hormonal na menopausa (THM e paridade. MÉTODOS: foram entrevistadas 157 mulheres na pós-menopausa, atendidas em dois ambulatórios públicos da cidade de São Paulo, São Paulo, Brasil. A obesidade foi determinada segundo o índice de massa corporal (IMC > 30,0 e segundo o percentual de gordura corporal (%GC > 37%. A obesidade abdominal foi determinada pela relação cintura-quadril (RCQ > 0,85. RESULTADOS: a prevalência de obesidade global foi 34,4% (segundo o IMC e de 40,1% (segundo o %GC. A prevalência de obesidade abdominal foi de 73,8%. Grande parte das entrevistadas referiu até sete anos de instrução formal (47,8%, foi considerada sedentária ou insuficientemente ativa (52,3% e nunca tinha utilizado THM oral ou tinha utilizado por menos de 12 meses (72,0%. Foi constatada maior prevalência de obesidade global no grupo de mulheres sedentárias ou insuficientemente ativas e no grupo de não usuárias de THM (pOBJECTIVES: to evaluate the body and abdominal obesity in post-menopausal women, according to educational level, level of physical activity, use of hormone therapy (HT, and parity. METHODS: 157 post-menopausal women, attending two public out-patients clinics in the city of São Paulo, State of São Paulo, Brazil, were interviewed. The prevalence of body obesity was calculated using the body mass index (BMI >30.0 and the body fat percentage (%BF > 37%. Abdominal obesity was calculated using the waist hip ratio (WHR >0.85. RESULTS: the prevalence of body obesity was 34.4% (using the BMI and 40.1% (using %BF. The prevalence of abdominal obesity was 73.8%. Most of the women had up to seven years of formal schooling (47.8%, were considered sedentary or insufficiently active (52.3%, and had never used oral HT or had been using it for less than 12 months (72

  11. Microrna-139-5p Inhibits Epithelial-Mesenchymal Transition and Fibrosis in Post-Menopausal Women with Interstitial Cystitis by Targeting LPAR4 via the PI3K/Akt Signaling Pathway.

    Science.gov (United States)

    Jiang, Chen; Tong, Zhen; Fang, Wei-Lin; Fu, Qi-Bo; Gu, Yin-Jun; Lv, Ting-Ting; Liu, Dong-Ming; Xue, Wei; Lv, Jian-Wei

    2017-12-14

    The study explores whether miR-139-5p targeting LPAR4 affects epithelial-mesenchymal transition (EMT) and fibrosis in post-menopausal women with interstitial cystitis (IC) via the PI3K/Akt signaling pathway. Bladder tissues of IC and normal bladder tissues were collected. The pathology of bladder tissues was observed by HE, Masson and Picrosirius red staining. LPAR4 positive expression rate were determined by IHC. ELISA was performed to detect the levels of IL-6, IL-8, IL-10 and TNF-α. Rat IC models were randomized into seven different groups. miR-139-5p, LPAR1, LPAR2, LPAR3, LPAR4, LPAR5, P13K, Akt, E-cadherin, N-cadherin, Vimentin, TGF-β1 and CTGF expression were determined by RT-qPCR and Western blotting. Dual luciferase reporter gene assay verified that LPAR4 is a target gene of miR-139-5p. Fibrosis was a pathological manifestation of IC. The IC group showed higher LPAR4, PI3K, Akt, p-PI3K, p-Akt, N-cadherin, Vimentin, TGF-β1 and CTGF expression but lower miR-139-5p and E-cadherin expression than the normal group. The levels of IL-6, IL-8, IL-10 and TNF-α expression decreased while HB-EGF increased in the IC group in comparison of the normal group. Compared with the blank and NC groups, E-cadherin expression was increased in the miR-139-5p mimic and siRNA-LPAR4 groups, while LPAR4, PI3K, Akt, p-P13K, p-Akt, N-cadherin, Vimentin, TGF-β1 and CTGF expression were decreased. An opposite trend was found in the miR-139-5p inhibitor group. The miR-139-5p decreased in the miR-139-5p inhibitor + siRNA-LPAR4 and miR-139-5p inhibitor + wortmannin groups. Conclusively, miR-139-5p targeting LPAR4 inhibits EMT and fibrosis in post-menopausal IC women through the PI3K/Akt signaling pathway. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  12. Effects of the addition of a resistance training programme to a caloric restriction weight loss intervention on psychosocial factors in overweight and obese post-menopausal women: a Montreal Ottawa New Emerging Team study.

    Science.gov (United States)

    Messier, Virginie; Rabasa-Lhoret, Rémi; Doucet, Eric; Brochu, Martin; Lavoie, Jean-Marc; Karelis, Antony; Prud'homme, Denis; Strychar, Irene

    2010-01-01

    The aim of this study was to examine the effects of the addition of a resistance training programme to a caloric restriction weight loss intervention on psychosocial profile. The study sample consisted of 137 overweight and obese post-menopausal women. Participants were randomized to a caloric restriction group and caloric restriction + resistance training group. Psychosocial, anthropometric, and metabolic variables were measured before and after the 6-month weight loss intervention. Both groups presented similar weight loss and there were no significant differences between the caloric restriction group and caloric restriction + resistance training group for changes in psychosocial profile. Thereafter, all participants were classified into quintiles based on the amount of weight loss. In all quintiles, women markedly improved body esteem and self-esteem, and decreased hunger and perceived risk for diabetes mellitus (P or =2.4 % body weight loss), decreases in disinhibition in quintiles 3-5 (> or =4.9 %), increases in self-efficacy in quintiles 3-5 (> or =4.9 %), and increases in health perceptions in quintile 5 (> or =11.1%). The results of this study do not support the hypothesis that the addition of a resistance training programme to a caloric restriction weight loss intervention has additional benefits on psychosocial profile. Overall, the significant improvements in the psychosocial profile observed were mostly accounted for by the degree of weight loss.

  13. Comparison of the in vivo uptake and metabolism of /sup 3/H-oestrone and /sup 3/H-oestradiol by normal breast and breast tumour tissues in post-menopausal women

    Energy Technology Data Exchange (ETDEWEB)

    McNeill, J.M.; Reed, M.J.; Beranek, P.A.; Bonney, R.C.; Ghilchik, M.W.; Robinson, D.J.; James, V.H.

    1986-08-15

    After infusion of /sup 3/H-oestradiol or /sup 3/H-oestrone into post-menopausal women with breast cancer, there was a significant uptake of both steroids by breast tumour and normal tissue. The proportion of oestrogen present in tumour tissue as /sup 3/H-oestradiol after infusion of /sup 3/H-oestradiol (89.4 +/- 3.5%, mean +/- SD, n = 4) was significantly higher (p less than 0.001) than in normal breast tissue (72.8 +/- 3.3%) obtained from the same women. Similarly, after infusion of /sup 3/H-oestrone, the proportion of oestrogen present as /sup 3/H-oestradiol (48.4 +/- 14.4%) was significantly higher than in normal breast tissue (19.1 +/- 6.4%). These results suggest that conversion of oestrone to oestradiol is enhanced in breast tumour tissue with little metabolism of oestradiol. This would account for the higher concentrations of oestradiol reported in breast tumour tissue in the presence of increased oestradiol 17 beta-hydroxysteroid dehydrogenase activity.

  14. Treatment patterns and duration in post-menopausal women with HR+/HER2- metastatic breast cancer in the US: a retrospective chart review in community oncology practices (2004-2010).

    Science.gov (United States)

    Macalalad, Alexander R; Hao, Yanni; Lin, Peggy L; Signorovitch, James E; Wu, Eric Q; Ohashi, Erika; Zhou, Zhou; Kelley, Caroline

    2015-02-01

    Clinical guidelines prefer endocrine therapy (ET) as initial treatment for post-menopausal women with hormone receptor positive (HR+)/human epidermal growth factor receptor 2 negative (HER2-) metastatic breast cancer (mBC). Chemotherapy (CT) should be reserved for patients who develop symptomatic visceral disease or have no clinical benefit after three sequential ET regimens. It is unclear if real-world clinical practice reflects these guidelines. To describe treatment patterns and treatment durations by lines of therapy for ET and CT among post-menopausal HR+/HER2- mBC patients. Charts were reviewed from a network of community-based oncology practices of eligible patients who had progressed after initiating adjuvant or first-line treatment for mBC between 1 January 2004 and 30 September 2010. Extracted chart data included demographics, treatment histories, and outcomes. Treatment duration was estimated using Kaplan-Meier estimators. A total of 144 patients were studied. Patients received a median of two lines of ET, and <10% had three or more lines of ET before receiving CT. From first line to second line, the median treatment duration was 11.6 to 4.9 months for ET overall; 13.8 to 10.5 months for anastrozole; 18.6 to 7.0 months for letrozole; and 5.1 to 2.9 months for fulvestrant. For CT, the median duration was 5.1 months in the first line and 3.7 months and below in subsequent lines. During the study period (1 January 2004 - 30 September 2012), most patients received <3 lines of ET before receiving CT. The drop in median duration of ET from first to second line suggests that single agent ETs might not be as effective beyond the first line. A key limitation of this study was the small sample size. In addition, more research is needed to further investigate the short treatment duration of fulvestrant across early lines of therapy (which could indicate lack of efficacy).

  15. Collagen type 1 (COL1A1) Sp1 binding site polymorphism is associated with osteoporotic fractures but not with bone density in post-menopausal women from the Canary Islands: a preliminary study.

    Science.gov (United States)

    Navarro, Mary C; Sosa, Manuel; del Pino-Montes, Javier; Torres, Armando; Salido, Eduardo; Saavedra, Pedro; Corral-Gudino, Luis; Montilla, Carlos A

    2007-02-01

    An association between the polymorphism for transcription factor Sp1 in the gene COL1A1 and low bone density (BMD) and osteoporotic fractures has been described but not confirmed for all races and ages. The aim of this preliminary work was to ascertain whether this association is present in women from the Canary Islands. Polymerase chain reaction RFLP was used to determine COL1A1 polymorphism Sp1 in 199 consecutive outpatient post-menopausal Caucasian women from the Canary Islands, aged 50-70 years. BMD was measured at lumbar spine and hip by DXA and at third lumbar vertebrae by QCT. Prevalent vertebral fractures were recorded on standard lateral X-ray film. Non-vertebral osteoporotic fractures were registered by medical record and self-reported history. Biochemical markers (serum osteocalcin, tartrate-resistant acid phosphatase), blood calcium and phosphate were also assessed. Distribution genotypes were 113 (50.8%) GG homozygotes, 73 (36.7%) Ss heterozygotes and 7 (3.5%) TT homozygotes. All patients with osteoporotic fractures carried the GG allele more frequently than TT homozygotic women. The odds ratio was 3.01 (95% CI 1.6-5.7) for prevalent vertebral fractures (n=62) and 2.33 (95% CI 1.2-4.4) for all osteoporotic fractures (n=65) for the T-carrying allele vs TT homozygotic women. There was no difference in BMD measured by DXA or QCT, nor in bone markers, blood calcium or phosphate. This preliminary study confirmed that the presence of at least one copy of the T allele is associated with osteoporotic fractures, but not with low BMD, in women from the Canary Islands.

  16. Diagnostic value of quantitative ultrasound and Osteoporosis self-assessment tool in comparison with DXA in detecting low bone mineral density in post-menopausal women in Riyadh, Kingdom of Saudi Arabia

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    AlJohara M AlQuaiz

    2015-11-01

    Full Text Available The objective of this study was to assess the diagnostic value of quantitative ultrasound (QUS and Osteoporosis self-assessment tool (OST compared with Dual Energy x-ray absorptiometry (DXA, and to identify the best cut-off value for determining low bone mineral density (BMD among postmenopausal women in Riyadh, Saudi Arabia. We conducted a community based cross-sectional study on 224 randomly selected post-menopausal women. Women visited primary heath care centers for answering self-administered questionnaireand screening for low BMD using QUS technique. OST was calculated based on age and weight. DXA scanwas performedforlumbar spine and femur neck at King Khalid University Hospital, Riyadh. Mean age of participants was 58.05(±8.97 years. The prevalence of low BMD at lumbar spine and femur neck was 56% and 28% respectively. The best cut-off value for QUS and OST was ≤-1 and ≤2 respectively. QUS yielded sensitivity and specificity of 73% vs 47% for lumbar spine (area under curve (AUC 0.56 and 84% vs 43% for femur neck (AUC 0.61. OST yielded sensitivity and specificity of 38% vs 84% for lumbar spine (AUC 0.62 and 48% vs 78% for femur neck (AUC 0.68. On combining the results, sensitivity and specificity were81% vs 41% (AUC 0.61 for lumbar spine and 89% vs 35% for femur neck (AUC 0.68 respectively. QUS and OST separately have limited diagnostic value, however on combining both instruments there is improvement in sensitivity to detect low BMD for both lumbar spine and femur neck.

  17. Effect of Dietary Supplementation with Conjugated Linoleic Acid on Bone Mineral Density, Bone Metabolism Markers and Inflammatory Markers in Healthy Post-menopausal Women: a Randomized Double Blind Placebo Controlled Trial

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    reza tavakoli

    2014-02-01

    Full Text Available AbstractIntroduction: Conjugated linoleic acid (CLA has been shown to positively influence on calcium and bone metabolism in experimental animals and cell culture, but there are limited human data available.Material and Methods: This double-blind, placebo-controlled trial study was done on 76 healthy post-menopausal women (aged 55.1 which randomly assigned to receive daily four CLA capsules G80 containing 3.2 g isomer blend (50:50% cis-9, trans-11: trans-10, cis-12 isomers or four capsules containing high oleic sunflower oil as placebo for 12 weeks. Urine and blood samples were collected at weeks 0 and 12 and were analyzed for biomarkers of calcium and bone metabolism and inflammatory markers (TNF-α and IL-6. Subjects completed 3-day dietary records during the trial, in weeks 0 (baseline, 6 and 12.Results: supplementation with 3.2 g CLA isomer blend (50:50% cis-9,trans-11:trans-10,cis-12 isomers for 12 weeks had no significant effects on bone formation markers (serum osteocalcin, bone-specific alkaline phosphatase or bone resorption (urine C-telopeptide-related fraction of type 1 collagen degradation products, parathyroid hormone (PTH, urinary calcium, urinary creatinine and CTP to creatinine ratio. But serum interlukine-6 did not change significantly over 12 weeks in postmenopausal women.Conclusion: Under the conditions tested in postmenopausal women, 3.2 g CLA isomer blend (50:50% cis-9, trans-11: trans-10, cis-12 isomers did not affect markers of bone metabolism and calcium.

  18. Post-Menopausal Vaginal Hemorrhage Related to the Use of a Hop-Containing Phytotherapeutic Product

    NARCIS (Netherlands)

    van Hunsel, Florence; van de Koppel, Sonja; van Puijenbroek, Eugène

    2015-01-01

    Two 54-year-old women developed abdominal cramps and vaginal hemorrhage as a result of endometrial hyperplasia during treatment with a hop-containing phytotherapeutic product (MenoCool®) for post-menopausal complaints. The women used the hop-containing phytotherapeutic product (418 mg of hop per

  19. Temporal changes in clinic and ambulatory blood pressure during cyclic post-menopausal hormone replacement therapy

    DEFF Research Database (Denmark)

    Sørensen, M B; Rasmussen, Verner; Jensen, Gorm Boje

    2000-01-01

    OBJECTIVE: Post-menopausal hormone replacement (HRT) might protect against cardiovascular disease, possibly by arterial vasodilation and reduced blood pressure. Progestogens are needed to avoid endometrial disease but vascular effects are controversial. The objective was to assess temporal changes...... in blood pressure (BP) by two measurement techniques during a cyclic hormone replacement regimen. DESIGN AND METHODS: Sixteen healthy and normotensive post-menopausal women (age 55 +/- 3 years) were studied in a placebo-controlled, randomized crossover study, and were randomized to 17beta-oestradiol plus...

  20. Association of Sex Hormones and SHBG with Depressive Symptoms in Post-menopausal Women: the Multi-Ethnic Study of Atherosclerosis

    Science.gov (United States)

    Colangelo, Laura A; Craft, Lynette L.; Ouyang, Pamela; Liu, Kiang; Schreiner, Pamela J.; Michos, Erin D.; Gapstur, Susan M

    2012-01-01

    Objective Sex hormones are thought to play an important role in the pathophysiology of depressive disorders in women. This study assessed the associations of total testosterone (T), bioavailable T, estradiol (E2), dehydroepiandrosterone (DHEA) and sex hormone binding globulin (SHBG) with depressive symptoms stratified on postmenopausal stage to determine whether associations were strongest for early postmenopausal women. Methods Women (N=1824) free of depressive symptoms at baseline (2000–2002) in the Multi-Ethnic Study of Atherosclerosis were categorized into tertiles of years postmenopause: T1, 0–10 years; T2, 11–20 years; and T3, 21–58 years. Multivariable-adjusted relative risks (RR) and 95% confidence intervals were computed for the incidence of depressive symptoms, as defined by a score of 16 or higher on the Center for Epidemiologic Studies Depression scale at examination 3 (2004–2005). Results In analysis including all sex hormones, the RRs for incident depressive symptoms associated with 1 unit higher log(total T) was 0.57 (p=0.13), log(E2) was 0.78 (p=0.04), log(SHBG) was 1.84 (p=0.003) and log(DHEA) was 1.45 (p=0.08) in T1. Without adjustment for SHBG, the RR for log(bioavailable T) was 0.16 (p=0.04). However, in T2 and T3, there were no meaningful associations of hormone or SHBG levels with incident depressive symptoms. When stratified by HT use, results were consistent for HT users but attenuated for HT non-users. Conclusions In women early postmenopause, sex hormones were associated with incident depressive symptoms. PMID:22415566

  1. Risk of breast cancer by type of menopausal hormone therapy: a case-control study among post-menopausal women in France.

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    Emilie Cordina-Duverger

    Full Text Available BACKGROUND: There is extensive epidemiological evidence that menopausal hormone therapy (MHT increases breast cancer risk, particularly combinations of estrogen and progestagen (EP. We investigated the effects of the specific formulations and types of therapies used by French women. Progestagen constituents, regimen (continuous or sequential treatment by the progestagen, and time interval between onset of menopause and start of MHT were examined. METHODS: We conducted a population-based case-control study in France in 1555 menopausal women (739 cases and 816 controls. Detailed information on MHT use was obtained during in-person interviews. Odds ratios and 95% confidence interval adjusted for breast cancer risk factors were calculated. RESULTS: We found that breast cancer risk differed by type of progestagen among current users of EP therapies. No increased risk was apparent among EP therapy users treated with natural micronized progesterone. Among users of EP therapy containing a synthetic progestin, the odds ratio was 1.57 (0.99-2.49 for progesterone-derived and 3.35 (1.07-10.4 for testosterone-derived progestagen. Women with continuous regimen were at greater risk than women treated sequentially, but regimen and type of progestagen could not be investigated independently, as almost all EP combinations containing a testosterone-derivative were administered continuously and vice-versa. Tibolone was also associated with an increased risk of breast cancer. Early users of MHT after onset of menopause were at greater risk than users who delayed treatment. CONCLUSION: This study confirms differential effects on breast cancer risk of progestagens and regimens specifically used in France. Formulation of EP therapies containing natural progesterone, frequently prescribed in France, was not associated with increased risk of breast cancer but may poorly protect against endometrial cancer.

  2. Analysis of the Relationship between Estradiol and Follicle-Stimulating Hormone Concentrations and Polymorphisms of Apolipoprotein E and LeptinGenes in Women Post-Menopause.

    Science.gov (United States)

    Rył, Aleksandra; Jasiewicz, Andrzej; Grzywacz, Anna; Adler, Grażyna; Skonieczna-Żydecka, Karolina; Rotter, Iwona; Sipak-Szmigiel, Olimpia; Rumianowski, Bogdan; Karakiewicz, Beata; Jurczak, Anna; Parczewski, Miłosz; Urbańska, Anna; Grabowska, Marta; Laszczyńska, Maria

    2016-05-28

    Menopause is the permanent cessation of menstruation due to loss of ovarian follicular activity. A review of the available literature indicates that correlations between the changes that take place in a woman's body after menopause and different genetic variants are still being sought. The study was conducted in 252 women who had completed physiological menopause. The women were divided into groups according to the time elapsed since menopause. The total concentrations of estradiol and follicle-stimulating hormone were determined by means of electrochemiluminescence. The apolipoprotein E (APOE) and lepitn (LEP) genotypes were determined by real-time PCR and polymerase chain reaction-restriction fragment length polymorphism, respectively. We observed that people with the APOE3/E3 genotype entered menopause insignificantly later compared to other genotypes. Additionally, in the group of patients with the APOE3/E3 genotypes, differences in the E2 concentration were significantly related to the time since their last menstruation. There is no association found in the literature between these polymorphisms of the LEP gene and hormones. To date, attempts to formulate a model describing the association between E2 and FSH concentration with the polymorphisms of various genes of menopause in women have not been successful. This relationship is difficult to study because of the number of nongenetic factors. Environmental factors can explain variation in postmenopausal changes in hormone levels.

  3. Analysis of the Relationship between Estradiol and Follicle-Stimulating Hormone Concentrations and Polymorphisms of Apolipoprotein E and LeptinGenes in Women Post-Menopause

    Directory of Open Access Journals (Sweden)

    Aleksandra Rył

    2016-05-01

    Full Text Available Background: Menopause is the permanent cessation of menstruation due to loss of ovarian follicular activity. A review of the available literature indicates that correlations between the changes that take place in a woman’s body after menopause and different genetic variants are still being sought. Methods: The study was conducted in 252 women who had completed physiological menopause. The women were divided into groups according to the time elapsed since menopause. The total concentrations of estradiol and follicle-stimulating hormone were determined by means of electrochemiluminescence. The apolipoprotein E (APOE and lepitn (LEP genotypes were determined by real-time PCR and polymerase chain reaction–restriction fragment length polymorphism, respectively. Results: We observed that people with the APOE3/E3 genotype entered menopause insignificantly later compared to other genotypes. Additionally, in the group of patients with the APOE3/E3 genotypes, differences in the E2 concentration were significantly related to the time since their last menstruation. There is no association found in the literature between these polymorphisms of the LEP gene and hormones. Conclusions: To date, attempts to formulate a model describing the association between E2 and FSH concentration with the polymorphisms of various genes of menopause in women have not been successful. This relationship is difficult to study because of the number of nongenetic factors. Environmental factors can explain variation in postmenopausal changes in hormone levels.

  4. Low-Load Very High-Repetition Resistance Training Attenuates Bone Loss at the Lumbar Spine in Active Post-menopausal Women.

    Science.gov (United States)

    Nicholson, Vaughan P; McKean, Mark R; Slater, Gary J; Kerr, Ava; Burkett, Brendan J

    2015-06-01

    This study determined the effect of 6 months of low-load very high-repetition resistance training on bone mineral density (BMD) and body composition in nonosteoporotic middle-aged and older women. Fifty healthy, active community-dwelling women aged 56-75 years took part in the two-group, repeated-measures randomized controlled trial. Participants either undertook 6 months of low-load very high-repetition resistance training in the form of BodyPump™ or served as control participants. Outcome measures included BMD at the lumbar spine, hip, and total body; total fat mass; fat-free soft tissue mass and maximal isotonic strength. Significant group-by-time interactions were found for lumbar spine BMD and maximal strength in favor of the BodyPump™ group. No favorable effects were found for hip BMD, total body BMD, total fat mass, or fat-free soft tissue mass. Three participants withdrew from the intervention group due to injury or fear of injury associated with training. Under the conditions used in this research, low-load very high-repetition resistance training is effective at attenuating losses in lumbar spine BMD compared to controls in healthy, active women aged over 55 years but did not influence hip and total body BMD or fat mass and fat-free soft tissue mass.

  5. Treatment of Sweating, Hot Flushing and Sleep ‎Disturbance in Peri and Post MenopausalWomen with Oral Pometone

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    Milal Muhammad Al- Jeborry

    2017-12-01

    Full Text Available Vasomotor symptoms, such as hot flushes and night sweats, are very common during the menopausal transition. One of the important alternative treatments is foods or supplements enriched with phytoestrogens. Aim of the study To assess the efficacy, safety and acceptability of pometone supplements for reducing sweating, hot flushes and sleep disturbance in peri and postmenopausal women. Methods This cross sectional randomized clinical therapeutic trail involved 44 peri and postmenopausal women. All patients took oral pometone capsule 500mg twice daily for one month period. Result The mean of hot flush, sweating score before treatment was 8.11±1.72. After four weeks of treatment, it became 1.36 ±2.10; P value was < 0.0001. The mean of sleep disturbance score before treatment was 4.40±3.03. After four weeks of treatment, it become 1.22 ±1.80 ; P value was  < 0.0001 . No side effect was reported during the course of this study. Conclusion Pometone is effective, safe and cheep treatment to reduce hot flushes , night sweat and sleep disturbance in peri and postmenopausal women

  6. Correlative analysis of plasma and urine neopterin levels in the pre- and post-menopausal women with periodontitis, following nonsurgical periodontal therapy

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    Jammula Surya Prasanna

    2017-01-01

    Full Text Available Context: Periodontitis is an inflammatory condition which is distinguished by the devastation of the supported tooth structures. In such inflammatory conditions, some biomarkers such as neopterin will be secreted and elevated in the body fluids, which can be used as a diagnostic marker for the present and future disease activity. Aims: Assessment of the neopterin as a biomarker in inflammatory conditions such as menopause and periodontitis. Settings and Design: A cross-sectional interventional study. Materials and Methods: Sixty female individuals with a mean age of 40–60 years with chronic periodontitis were included in this study. All were categorized into two groups of thirty each, depending on their menstrual history: Group I – thirty premenopausal women and Group II – thirty postmenopausal women. Urine and plasma were collected from both groups to estimate neopterin levels. ELISA kit was used to assess the neopterin levels at baseline and after 3 months of nonsurgical periodontal therapy (NSPT. Statistical Analysis Used: IBM SPSS version 21 software. Results: A significant depreciation in the mean values of all the parameters from baseline to 3 months (P < 0.001, in the intragroup analysis, was observed. Plasma (0.006 and urine (0.004 reduction was seen. Conclusions: In both the groups, in 3 months after NSPT, decreased neopterin levels were found, suggesting that the NSPT is the definitive therapy. Further, suggesting that, neopterin levels in the plasma and urine can be used as an index to identify the periodontal inflammation and destruction.

  7. Short- and long-term eating habit modification predict weight change in overweight, post-menopausal women: results from the WOMAN Study

    Science.gov (United States)

    Gibbs, Bethany Barone; Kinzel, Laura S.; Gabriel, Kelley Pettee; Chang, Yue-fang; Kuller, Lewis H.

    2012-01-01

    Background Standard behavioral obesity treatment produces poor long-term results. Focusing on healthy eating behaviors, rather than caloric intake, may be an alternative strategy. Furthermore, important behaviors might differ for short- vs. long-term weight control. Objective To describe and compare associations between changes in eating behaviors and weight after 6 and 48 months Design Secondary analysis of data collected during a randomized weight loss intervention trial with 48-month follow-up Participants 465 overweight and obese postmenopausal women enrolled in the Women on the Move through Activity and Nutrition (WOMAN) Study Main outcome measures Changes in weight from baseline to 6 and 48 months. Statistical analyses performed Linear regression models examined the associations between 6- and 48-month changes in eating habits assessed by the Conner Diet Habit Survey and changes in weight. Analyses were conducted in the combined study population and stratified by randomization group. Results At 6 months in the combined population, weight loss was independently associated with decreased desserts (peating (p=0.042), sugar-sweetened beverages (p=0.009), and fried foods (peating behaviors were associated with weight change, though important behaviors differed for short- and long-term weight change and by randomization group. Future studies should determine whether interventions targeting these behaviors could improve long-term obesity treatment outcomes. PMID:22939439

  8. Vitamin D inadequacy in Belgian postmenopausal osteoporotic women

    Directory of Open Access Journals (Sweden)

    Collette Julien

    2007-04-01

    Full Text Available Abstract Background Inadequate serum vitamin D [25(OHD] concentrations are associated with secondary hyperparathyroidism, increased bone turnover and bone loss, which increase fracture risk. The objective of this study is to assess the prevalence of inadequate serum 25(OHD concentrations in postmenopausal Belgian women. Opinions with regard to the definition of vitamin D deficiency and adequate vitamin D status vary widely and there are no clear international agreements on what constitute adequate concentrations of vitamin D. Methods Assessment of 25-hydroxyvitamin D [25(OHD] and parathyroid hormone was performed in 1195 Belgian postmenopausal women aged over 50 years. Main analysis has been performed in the whole study population and according to the previous use of vitamin D and calcium supplements. Four cut-offs of 25(OHD inadequacy were fixed : Results Mean (SD age of the patients was 76.9 (7.5 years, body mass index was 25.7 (4.5 kg/m2. Concentrations of 25(OHD were 52.5 (21.4 nmol/L. In the whole study population, the prevalence of 25(OHD inadequacy was 91.3 %, 87.5 %, 43.1 % and 15.9% when considering cut-offs of 80, 75, 50 and 30 nmol/L, respectively. Women who used vitamin D supplements, alone or combined with calcium supplements, had higher concentrations of 25(OHD than non-users. Significant inverse correlations were found between age/serum PTH and serum 25(OHD (r = -0.23/r = -0.31 and also between age/serum PTH and femoral neck BMD (r = -0.29/r = -0.15. There is a significant positive relation between age and PTH (r = 0.16, serum 25(OHD and femoral neck BMD (r = 0.07. (P Vitamin D concentrations varied with the season of sampling but did not reach statistical significance (P = 0.09. Conclusion This study points out a high prevalence of vitamin D inadequacy in Belgian postmenopausal osteoporotic women, even among subjects receiving vitamin D supplements.

  9. Mandibulo-osseous predictors of osteoporosis: A double-blind study on the correlation and comparison of mental index with bone mineral density in post-menopausal women

    Directory of Open Access Journals (Sweden)

    Shefali Waghray

    2015-01-01

    Full Text Available Introduction: Osteoporosis is a metabolic bone disease characterized by microarchitectural deterioration in bone tissue leading to fractures, and is essentially a preventable disease when detected in the early stages. Novel methods for early identification of osteoporosis can have a great impact in combating this otherwise progressive disease. Aims: The present study was conducted with the objectives of evaluating the precision of a radiomorphometric index [mental index (MI] measured on a panoramic radiograph in early diagnosis of osteoporosis and finding its correlation with bone mineral density (BMD measured by digital X-ray radiogrammetry method. Materials and Methods: The study consisted of 71 women who were in natural menopause. The MI was calculated by two investigators, with each investigator recording two sets of measurements. The BMD was assessed and the T-score was obtained by digital X-ray radiogrammetry method. Based on the T-score obtained, the patients were divided into three study groups of normal (n = 24, osteopenic (n = 30, and osteoporotic (n = 17. The values obtained were tabulated for statistical analysis. Results: In the present study, it was found that there was a statistically significant difference in the mean scores of MI among normal, osteopenic, and osteoporotic subjects. Normal subjects had significantly higher MI (P < 0.001 than the osteopenic subjects and, similarly, the osteopenic subjects had significantly higher MI (P < 0.001 than the osteoporotic subjects. The inter- and intra-investigator variability was found to be low. Conclusion: Based on the results of the present study, it was concluded that a simple radiomorphometric index (MI which is relatively easier to measure on a panoramic radiograph can be an indicator of osteoporosis and may aid in early detection and treatment planning of one of the most prevalent metabolic bone diseases.

  10. Bone remodeling in post-menopausal osteoporosis.

    Science.gov (United States)

    Lerner, U H

    2006-07-01

    Bone mass in the skeleton is dependent on the coordinated activities of bone-forming osteoblasts and bone-resorbing osteoclasts in discrete bone multi-cellular units. Remodeling of bone in these units is important not only for maintaining bone mass, but also to repair microdamage, to prevent accumulation of too much old bone, and for mineral homeostasis. The activities of osteoblasts and osteoclasts are controlled by a variety of hormones and cytokines, as well as by mechanical loading. Most importantly, sex hormones are very crucial for keeping bone mass in balance, and the lack of either estrogen or testosterone leads to decreased bone mass and increased risk for osteoporosis. The prevalence of osteoporotic fractures is increasing dramatically in the Western part of the world and is a major health problem in many countries. In the present review, the cellular and molecular mechanisms controlling bone remodeling and the influence of sex hormones on these processes are summarized. In a separate paper in this issue, the pathogenesis of post-menopausal osteoporosis will be compared with that of inflammation-induced bone remodeling, including the evidence for and against the hypothesis that concomitant post-menopausal osteoporotic disease influences the progression of periodontal disease.

  11. Metabolismo de repouso de mulheres pós-menopausadas submetidas a programa de treinamento com pesos (hipertrofia Resting metabolism of post-menopause women submitted to a training program with weights (hypertrophy

    Directory of Open Access Journals (Sweden)

    Mara Cléia Trevisan

    2007-04-01

    Full Text Available O estudo objetivou avaliar o gasto energético de repouso (GER de mulheres pós-menopausadas submetidas a programa de treinamento com pesos. Foram estudadas 30 mulheres (FSH > 40mIU/mL entre 45 e 70 anos, separadas em dois grupos (GT: treinamento, n = 15 e GC: controle, n = 15. Calculou-se o índice de massa corporal (kg/m² e por meio da impedância bioelétrica (BIA determinaram-se o percentual de gordura corporal e a massa muscular. O GER foi obtido por meio da calorimetria indireta (O2 e CO2 respiratórios e calculado pela equação de Weir. A mensuração ocorreu após 12 horas de jejum, durante 30 minutos sob temperatura e umidade controladas. O GT participou do programa de treinamento com pesos durante 16 semanas, na freqüência de três vezes por semana. Os dados analisados pelos testes t de Student, Mann-Whitney e ANOVA (p The study had as objective to evaluate the resting energy expenditure (REE of post-menopause women submitted to a training program with weights. Thirty women, age between 45 and 70 years (FSH > 40 mIUmL, separated in two groups (TG: training n = 15 and CG: control n = 15 were studied. The body mass index (kg/m² was calculated and the body fat percentage and the muscular mass were determined through bioelectric impedance (BIA. The REE was obtained through indirect calorimetry (respiratory O2 and CO2 and calculated by the Weir equation. The measurement occurred after 12 hours of fasting, during 30 minutes under controlled temperature and humidity. The TG participated of the training program with weights during 16 weeks, in the frequency of three times per week. The analyzed data by the t-Student, Mann-Whitney and ANOVA tests (p < 0.05 demonstrated that the TG had body mass increased in the 1.8 kg mean, muscular mass in 2.0 kg and the REE presented increase of 8.4% in relation to the CG. In conclusion, the training with weights increased muscular mass and REE. Therefore, this kind of exercise is recommended part of

  12. Quality of life in post-menopausal osteoporosis

    Directory of Open Access Journals (Sweden)

    Ortolani Sergio

    2005-12-01

    Full Text Available Abstract Background To evaluate the impact of osteoporosis on the patients' quality of life, particularly in the absence of fractures. Methods 100 post-menopausal women (age 50-85 - 62 with uncomplicated primary osteoporosis and 38 with primary osteoporosis complicated by vertebral fractures; all already treated - were studied using two validated questionnaires: Qualeffo-41 for quality of life in osteoporosis, and Zung for depression. Data were compared to those of 35 controls of comparable age, affected by a different chronic disease (hypothyroidism. Results Family history of osteoporosis and T-score of spine were similar in the two subgroups of osteoporotic women. Body mass index, age at menopause and education level were similar in the two subgroups of osteoporotic women and in the control group. The patients affected by osteoporosis perceived it as a disease affecting their personal life with undesirable consequences: chronic pain (66% of women with fractures and 40% of women without fractures, impaired physical ability, reduced social activity, poor well-being (21% of women without fractures and depressed mood (42% of women irrespective of fractures. Overall, 41% of the women showed a reduced quality of life. On the contrary, in the control group only 11% reported a reduced quality of life. Conclusion The quality of life of osteoporotic patients should be investigated even before fractures, in order to develop appropriate counselling, support and care interventions to help patients develop efficient strategies for accepting the disease and coping with it.

  13. Efectos de la terapia de reemplazo hormonal sobre la función autonómica en mujeres postmenopáusicas Effects of estrogen replacement therapy on autonomic function of post-menopausal women

    Directory of Open Access Journals (Sweden)

    Juan C Guzmán

    2007-02-01

    para mejorar los síntomas de la menopausia durante un tiempo corto, principalmente en mujeres postmenopáusicas jóvenes no hipertensas.Background: estrogen deficit during menopause may be related to cardiac autonomic function imbalance, reducing the cardiovagal reflex response that could potentially increase cardiovascular risk. The physiological mechanisms that lead to this alteration in postmenopausal women remain unclear. In this article, the effect of hormonal replacement therapy on autonomic function in women submitted to hysterectomy is discussed. Methods: Fifty women with a previous hysterectomy and amenorrhea for 1 year prior to surgery were enrolled in a prospective randomized crossover double-blind placebo controlled trial. Either oral estrogen replacement therapy (ERT conjugated estrogens 0.625 mg once a day or placebo, were randomly administered in a crossover design during 12 weeks with a 2 week washout period. Cardiovagal autonomic function was assessed by conventional techniques and through venous occlusion plethysmography in order to evaluate vascular autonomic function calculating forearm blood flow (FBF and peripheral vascular resistance (PVR at baseline, and during head-up tilt (HUT and a non-hypotensive stimuli (-10mmHg lower-body negative pressure (LBNP. Results: No differences were found in cardiovagal autonomic function comparing ERT vs. placebo at baseline resting conditions, nor during HUT and LBNP. A significant difference was identified in supine FBF [1.9(0.5 vs. 1.5(0.5, p=0.02] as well as in PVR [53.5(18.2 vs. 68.6(34, p=0.02] comparing ERT vs. placebo interventions. Conclusions: Short term ERT did not improve cardiovascular autonomic reflex responses in postmenopausal women, but increased vascular relaxation primarily by reducing peripheral vascular resistance. Hormone replacement therapy can be used under adequate supervision in order to improve menopausal symptoms during a short period of time, mainly in young non-hypertensive post-menopausal

  14. Temporal changes in clinic and ambulatory blood pressure during cyclic post-menopausal hormone replacement therapy

    DEFF Research Database (Denmark)

    Sørensen, M B; Rasmussen, Verner; Jensen, Gorm Boje

    2000-01-01

    OBJECTIVE: Post-menopausal hormone replacement (HRT) might protect against cardiovascular disease, possibly by arterial vasodilation and reduced blood pressure. Progestogens are needed to avoid endometrial disease but vascular effects are controversial. The objective was to assess temporal changes...... in blood pressure (BP) by two measurement techniques during a cyclic hormone replacement regimen. DESIGN AND METHODS: Sixteen healthy and normotensive post-menopausal women (age 55 +/- 3 years) were studied in a placebo-controlled, randomized crossover study, and were randomized to 17beta-oestradiol plus...... and in the ninth weeks of treatment in both periods. RESULTS: Clinic systolic and diastolic BP were reduced after 10 days of oestradiol (-5.1 and -3.2 mmHg respectively, P

  15. Hormone-related factors and post-menopausal onset depression: results from KNHANES (2010-2012).

    Science.gov (United States)

    Jung, Sun Jae; Shin, Aesun; Kang, Daehee

    2015-04-01

    Although hypotheses have been proposed regarding the biological mechanisms of hormonal fluctuations in mood disorders, few epidemiological studies have addressed this issue. The aim of this study was to examine the association between hormone-related life events and postmenopausal depression. Of 13,918 women who participated in the Korean National Health and Nutrition Examination Survey (KNHANES) V, a total of 4869 post-menopausal women who had completed information on depression onset age and additional reproductive factors were included in the analysis. A multivariate logistic regression was applied to calculate the odds ratios between reproductive factors and post-menopausal onset depression. A total of 276 women (5.7%) were diagnosed with depression after menopause. Longer reproductive years were associated with a reduced risk of depression (for more than 35 reproductive years: OR=0.41, 95% CI: 0.27-0.62, P-trenddepression (OR=0.35, 95% CI: 0.22-0.55) compared to the women with a menopausal age younger than 46 years. Greater numbers of pregnancies and exogenous hormone use were also associated with increased risk of depression. All data were collected from interviews using questionnaires. There may be some inaccuracies in recall of lifetime reproductive events, but women generally recalled their hormonal events correctly. Early menopause and the use of exogenous hormones were associated with the risk of post-menopausal depression. Clinicians should closely monitor and consider further screening for depressed women who undergo early menopause or those with exogenous hormone use. Copyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.

  16. Evaluation of Levothyroxine Bioavailability after Oral Administration of a Fixed Combination of Soy Isoflavones in Post-menopausal Female Volunteers.

    Science.gov (United States)

    Persiani, S; Sala, F; Manzotti, C; Colovic, M; Zangarini, M; Donazzolo, Y; Barbetta, B; Vitalini, C; Giacovelli, G; Benvenuti, C; Rovati, L C

    2016-03-01

    Post-menopausal women under treatment with levothyroxine for their medical conditions may take concomitantly dietary supplements containing soy isoflavones in combination to treat their post-menopausal symptoms. The aim of this study was to investigate the effect of a fixed combination of soy isoflavones on the oral bioavailability of levothyroxine in post-menopausal female volunteers. 12 healthy post-menopausal female, who were on stable oral levothyroxine as replacement/supplementation therapy for hypothyroidism, received a single recommended oral dose of a food supplement containing 60 mg of soy isoflavones (>19% genistin and daidzin) concomitantly with (test) and 6 h later (reference) the administration of levothyroxine in a randomized, open label, crossover fashion. Plasma concentrations of levothyroxine and soy isoflavones (daidzin, daidzein, genistin, genistein, S-equol) were determined by LC-MS/MS. Pharmacokinetic (PK) parameters were determined by non-compartmental analysis. No effect of soy isoflavones was assumed if the 90% confidence intervals (CIs) for the estimated ratio test/reference was included in the acceptance limits 0.80-1.25 for PK parameters Cmax and AUCt. The test/reference ratios Cmax and AUCt of levothyroxine were very close to unity (1.02 and 0.99, respectively) and the corresponding 90% CIs (0.99-1.04 and 0.88-1.12, respectively) fell entirely within the acceptance bioequivalence limits. The combination of soy isoflavones used in the present investigation does not affect the rate and extent of levothyroxine absorption when administered concomitantly in post-menopausal women. © Georg Thieme Verlag KG Stuttgart · New York.

  17. A experiência da perimenopausa e pós-menopausa com mulheres que fazem uso ou não da terapia de reposição hormonal Peri-menopausal and post-menopausal experience among women with and without hormone replacement therapy

    Directory of Open Access Journals (Sweden)

    Sônia Maria Garcia Vigeta

    2004-12-01

    Full Text Available Este estudo, uma pesquisa qualitativa, tem por objetivo conhecer o significado da perimenopausa/pós-menopausa e o vivenciar de seus sinais e sintomas para mulheres que usam ou não a terapia de reposição hormonal (TRH. Os dados empíricos foram obtidos por meio de entrevista realizada com 11 mulheres, de 45 a 59 anos de idade, usuárias ou não de TRH e freqüentadoras de diferentes serviços de saúde no Município de São Paulo, Brasil. A análise foi realizada por meio da hermenêutica. Os resultados mais significativos revelam que as mulheres que não fazem uso da TRH apresentam os sintomas da perimenopausa, mas convivem com eles; as mulheres que fazem uso da isoflavona procuram por terapias alternativas para os sintomas que as incomodam; ao passo que as mulheres sob o uso da TRH declaram uma sensação de bem estar. O artigo sugere a importância de capacitar os profissionais da área de saúde para compreenderem que a perimenopausa e a pós-menopausa fazem parte do processo de envelhecimento e, portanto, devem ser consideradas como processo vital e não patológico.This qualitative study focuses on peri-menopausal and post-menopausal experience and its signs and symptoms for women with and without use of hormone replacement therapy (HRT. Empirical data were obtained through interviews with 11 women (range: 45 to 59 years with or without HRT at different health clinics in the Municipality of São Paulo, Brazil. The analysis used the hermeneutic method. Most significantly, women who are not on HRT present peri-menopausal symptoms, but they "live with" such symptoms; meanwhile, women in use of isoflavone rely on alternative therapies for the bothersome symptoms; women using HRT report a feeling of wellbeing. The article suggests the importance of training health professionals to understand the peri-menopausal and post-menopausal periods as part of the aging process, and thus as a vital rather than pathological process.

  18. Migraine in the post-menopausal period is associated with higher levels of mood disorders, disability, and more menopausal symptoms

    OpenAIRE

    Carturan, Paula; Scorcine, Claudio; Fragoso, Yara Dadalti

    2016-01-01

    ABSTRACT Objective To assess the prevalence of headache in post-menopausal women. Methods Women attending gynecology outpatient services in the coastal region of the state of Sao Paulo, Brazil were invited to participate in this study. Only those with non-surgical menopause and no hormone replacement therapy were included. Prevalence and characterization of headaches were assessed, as well as the burden of migraine, traits of anxiety and depression, and menopausal symptomatology. Results...

  19. Lycium chinense Improves Post-Menopausal Obesity via Regulation of PPAR-γ and Estrogen Receptor-α/β Expressions.

    Science.gov (United States)

    Kim, Mi Hye; Kim, Eun-Jung; Choi, You Yeon; Hong, Jongki; Yang, Woong Mo

    2017-01-01

    The fruit of Lycium chinense Miller (Solanaceae) is used as a functional food and a medicinal herb for treating many specific health concerns. Weight gain induced by estrogen deficiency is a problem for post-menopausal women around the globe. The present study investigates the effects of aqueous extract of L. chinense (LC) on post-menopausal obesity. Female C57BL/6 mice were ovariectomized and fed on high-fat diet (HFD) for 12 weeks to induce post-menopausal obesity. LC extract (1[Formula: see text]mg/kg and 10[Formula: see text]mg/kg) was orally administrated for 6 weeks with continuous HFD feeding. Ovarian adipose tissues and uterus were weighed. Serum triglyceride, cholesterol, LDL-cholesterol and fasting glucose levels were analyzed. The expressions of adipocyte-specific factors and estrogen receptors (ERs) were investigated. Additionally, lipid accumulation was confirmed in differentiated 3T3-L1 adipocytes. Increased body weight due to post-menopausal obesity was ameliorated about 14.7% and 17.76% by treatment of 1[Formula: see text]mg/kg and 10[Formula: see text]mg/kg LC, respectively. LC treatment reduced both of serum lipid and fasting blood glucose levels. Adipocyte hypertrophy and fatty liver were ameliorated in LC-treated groups. In LC-treated adipocyte cells, lipid accumulation was significantly inhibited. The expression of perilipin in adipose tissues was decreased by LC. In addition, expression of PPAR-[Formula: see text] protein was down-regulated in adipose tissues and differentiated adipocytes, while GLUT4 expression was increased in adipose tissues by LC treatment. Moreover, LC treatment up-regulated the expressions of ER-[Formula: see text]/[Formula: see text] accompanied with increased uterine weight. These results showed the ameliorative effects of LC on overweight after menopause. Post-menopausal obesity may be improved by LC treatment.

  20. Clinicopathological Spectrum of Endometrial Changes in Peri-menopausal and Post-menopausal Abnormal Uterine Bleeding: A 2 Years Study.

    Science.gov (United States)

    Damle, Rajshri P; Dravid, N V; Suryawanshi, Kishor H; Gadre, Arundhati S; Bagale, Priya S; Ahire, Neelam

    2013-12-01

    Abnormal uterine bleeding is the Common presenting complaint in Gynaecology Outpatient Department in all age groups. It is due to the anovulatory cycles which are commonly seen in adolescent and peri-menopausal women. Abnormal uterine bleeding is caused by wide variety of organic or non-organic causes. Histopathological examination of endometrial sample remains the gold standard for diagnosis of endometrial pathology. To study the clinicopathological spectrum of endometrium in abnormal uterine bleeding in peri-menopausal and post-menopausal age groups. The study included prospective analysis of 119 cases of endometrial samples in patients of abnormal uterine bleeding above 40 years of age. The specimens were routinely processed and H&E stained slides were studied. Patients were categorized into peri-menopausal (40-49 years) and post-menopausal (> 50 years) age group. A total of 119 specimens of endometrium were analyzed. Maximum number (73.94%) of cases were from peri-menopausal age group. The most common presenting complaint was menorrhagia (48.86%) followed by post-menopausal bleeding (26.05%). In peri-menopausal age group proliferative endometrium (35.22%) was the predominant histopathological pattern followed by endometrial hyperplasia (23.86%). Atrophic endometrium (25.80%) was the most frequent finding followed by endometrial hyperplasia (19.35%) in post-menopausal age group. Three cases of endometrial carcinoma were reported in post-menopausal age group only. A thorough histopathological work up and clinical correlation is mandatory in cases of abnormal uterine bleeding above the age of 40 years to find out organic lesions. Careful screening can detect early cancer of endometrium which has excellent prognosis and it will help in further management.

  1. Comparative study of transvaginal hysterosonography and biopsy for theevaluation of post-menopausal bleeding

    International Nuclear Information System (INIS)

    Abu-Ghazzeh, Y.; Sahkoury, Waheed A.; Barqawi, R.

    1999-01-01

    The aim of this prospective study was to evaluate transvaginalhysterosonography (TVHS) in post-menopausal bleeding (PMB) as an alternativeto endometrial biopsy. The study was conducted at the Zarka MilitaryHospital, Amman, Jordan, over a one year period from 1996 to 1997. The studycomprised 98 women presenting with post-menopausal bleeding who had beenlisted for diagnostic dilatation and curettage. Transvaginal sonography (TVS)and transvaginal hysterosonography were performed one week before operation.The mean age of the women was 75 years, and all of them had their menopausefor at least six months. Sixty-one women (62%) demonstrated endometrialthickness of more than 5mm by transvaginal sonography. All the women hadtransvaginal hysterosonography, except seven on whom hysterosonography couldnot be performed for technical reasons and who had to be excluded from thestudy, leaving a total 54 women. TVS confirmed the presence of endoluminalmass in 30 of 54 women (60%). Twenty-two of the 30 endoluminal mass caseswere pedunculated while eight were sessile. Sixteen of the pedunculated caseswere endometrial polyps while the remaining six were fibroid polyps. Five ofthe sessile cases were fibroid, two were endometrial hyperplasia, and thelast one endometrial carcinoma. The other 44 out of the 98 patients alsounderwent transvaginal hysterosonography. No pathology could be detected inthese patients, but they were noted to have atrophic endometrium afterdilatation and curettage. The combination of transvaginal sonography andtransvaginal hysterosonography is both sensitive and specific with regard todetecting and excluding endoluminal masses as the cause of post-menopausalbleeding. Diagnostic dilatation and curettage fails to detect a largepercentage of some lesions, so TVS in combination with TVHS should beconsidered as the initial examination in the evaluation of all women withpost-menopausal bleeding. (author)

  2. HORMONE REPLACEMENT AND STRENGTH TRAINING POSITIVELY INFLUENCE BALANCE DURING GAIT IN POST-MENOPAUSAL FEMALES: A PILOT STUDY

    Directory of Open Access Journals (Sweden)

    Stephen D. Perry

    2005-12-01

    Full Text Available This study examined the effects of hormone replacement combined with strength training on improving dynamic balance control in post-menopausal women. Thirty one participating post-menopausal women were divided into three groups (hormone replacement (HR, non-hormone replacement (NR and control (CR group. HR and NR groups were tested for muscle strength and balance control during gait, prior to training and following a six week lower body strength training program. Quadriceps muscle strength was evaluated as isokinetic peak torque (60°·sec-1 using a CYBEX NORM and balance control was evaluated by center of mass - base of support relationships and ground reaction forces during gait perturbations. Only the HR group showed significantly (p < 0.05 improved balance control during the initial phase of unexpected gait termination and single stance periods while walking across uneven terrain following training. The strength gains in the HR group tended to be greater than in the NR group over the six week training program, although neither group showed statistically significant increases. The CR group showed no significant differences between testing times. HR in post-menopausal females may enhance dynamic balance control when combined with a strength training program, even if no statistically significant gains in strength are achieved

  3. Influência da proteína de soja e dos exercícios com pesos sobre o gasto energético de repouso de mulheres na pós-menopausa Influence of soy protein and exercises with weights on the resting energy expenditure of women in post-menopause

    Directory of Open Access Journals (Sweden)

    Mara Cléia Trevisan

    2010-01-01

    Full Text Available OBJETIVO: Analisar a influência da ingestão alimentar de proteína da soja e dos exercícios com pesos sobre o gasto energético de repouso (GER de mulheres na pós-menopausa. MÉTODOS: Ensaio clínico, 16 semanas, envolvendo 60 mulheres, 59 (7 anos, distribuídas em quatro grupos: G1 (proteína da soja e exercício, G2 (placebo e exercício, G3 (proteína da soja e sem exercício e G4 (placebo e sem exercício. A proteína da soja e o placebo (maltodextrina foram distribuídos, aleatoriamente, sob a forma de pó, na porção de 25 gramas/dia. Foram 10 exercícios com pesos, realizados em três sessões semanais, com 3 séries de 8-12 repetições cada, carga de 60%-80% de uma repetição máxima (RM. O GER foi calculado a partir do O2 e CO2, obtidos por calorimetria indireta (Quinton-QMC®, durante 30 minutos, sob temperatura e umidade controladas. Na análise estatística foi utilizada ANOVA, teste T de Student e regressão múltipla, por meio do software Stata 9.2, αOBJECTIVE: The main objective of this study was to analyze the influence of soy protein ingestion and exercises with weights, on resting energy expenditure (REE of women in post-menopause. METHODS: Clinical trial, 16 weeks, involving 60 women, 59 (7 years, distributed in 4 groups: G1 (soy protein and exercise, G2 (placebo and exercise, 3 (soy protein and without exercise and 4 (placebo and without exercise. Randomly, soy protein and placebo (maltodextrin were distributed in powder form, in portions of 25 grams/ day. There were 10 exercises with weights, performed in 3 sessions a week with 3 sets of 8-12 repetitions each, load of 60-80% of 1 maximum repetition (RM. The REE was calculated from the O2 and CO2, obtained through indirect calorimetry (Quinton QMC® for 30 minutes under controlled temperature and humidity. For statistical analysis, ANOVA, Student's t test and multiple regression were used with the software Stata 9.2, α<0.05. RESULTS: Women presented homogeneity in

  4. Associação entre os polimorfismos HaeIII e MspI do gene para o receptor alfa de estrogênio e densidade mamográfica em mulheres após a menopausa Association between HaeIII and MspI polymorphisms of estrogen receptor alpha gene and mammographic density in post-menopausal women

    Directory of Open Access Journals (Sweden)

    Eduardo Henrique de Moura Ramos

    2006-10-01

    Full Text Available OBJETIVO: Avaliar a presença dos polimorfismos HaeIII e MspI do gene para o receptor de estrogênio alfa, bem como fatores clínicos e suas possíveis associações com a densidade mamográfica em mulheres após a menopausa. MÉTODOS: Foram avaliadas 115 mulheres após a menopausa, não usuárias de terapia hormonal e sem lesão mamária clínica ou mamograficamente identificada. A densidade mamográfica foi determinada por três observadores independentes, tomando-se como base a classificação dos padrões mamográficos do ACR-BIRADS®, 2003 (duas avaliações subjetivas e uma computadorizada - Adobe Photoshop® 7.0. Amostras de raspado bucal foram obtidas para extração de DNA e em seguida foi realizada uma PCR-RFLP (Polymerase Chain Reation - Restriction Fragment Length Polymorphism para análise de polimorfismos presentes no íntron 1 e éxon 1 do gene do REalfa (HaeIII e MspI. RESULTADOS: O polimorfismo HaeIII foi encontrado em 43 (37,4% das 115 mulheres, ao passo que o MspI estava presente em 96 (83,5% das mesmas. Houve alto grau de concordância entre os três observadores na determinação da densidade mamográfica. Trinta e quatro (29,6% mulheres tinham mamas densas, e 81 (70,4%, mamas lipossubstituídas. CONCLUSÃO: Não houve associação entre o polimorfismo HaeIII do gene para o receptor de estrogênio alfa e densidade mamográfica (Fisher = 0,712. Houve associação próxima à significância estatística entre o polimorfismo MspI e densidade (Fisher = 0,098. Idade, paridade e índice de massa corporal mostraram-se associados com densidade mamográfica.PURPOSE: To assess the presence of estrogen receptor gene polymorphisms HaeIII and MspI as well as clinical factors, and their possible associations with high mammographic density in post-menopausal women. METHODS: One hundred and fifteen post-menopausal women, not in use of hormonal therapy and without clinical or mammographic lesions were evaluated. Three independent observers

  5. Menopausal symptoms: do life events predict severity of symptoms in peri- and post-menopause?

    Science.gov (United States)

    Pimenta, Filipa; Leal, Isabel; Maroco, João; Ramos, Catarina

    2012-08-01

    Hormonal changes during menopausal transition are linked to physical and psychological symptoms' emergence. This study aims to explore if life events predict menopausal symptoms. This cross-sectional research encompasses a community sample of 992 women who answered to socio-demographic, health, menopause-related and lifestyle questionnaires; menopausal symptoms and life events were assessed with validated instruments. Structural equation modeling was used to build a causal model. Menopausal status predicted only three symptoms: skin/facial hair changes (β=.136; p=.020), sexual (β=.157; p=.004) and, marginally, vasomotor symptoms (β=.094; p=.054). Life events predicted depressive mood (β=-.391; p=.002), anxiety (β=-.271; p=.003), perceived cognitive impairment (β=-.295; p=.003), body shape changes (β=-.136; p=.031), aches/pain (β=-.212; p=.007), skin/facial hair changes (β=-.171; p=.021), numbness (β=-.169; p=.015), perceived loss of control (β=-.234; p=.008), mouth, nails and hair changes (β=-.290; p=.004), vasomotor (β=-.113; p=.044) and sexual symptoms (β=-.208; p=.009). Although women in peri- and post-menopausal manifested higher symptoms' severity than their pre-menopausal counterparts, only three of the menopausal symptoms assessed were predicted by menopausal status. Since the vast majority of menopausal symptoms' severity was significantly influenced by the way women perceived their recent life events, it is concluded that the symptomatology exacerbation, in peri- and post-menopausal women, might be due to life conditions and events, rather than hormonal changes (nonetheless, the inverse influence should be investigated in future studies). Therefore, these should be accounted for in menopause-related clinical and research settings. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  6. Periodontal disease-associated micro-organisms in peri-menopausal and post-menopausal women using or not using hormone replacement therapy. A two-year follow-up study

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    Furuholm Jussi

    2010-04-01

    Full Text Available Abstract Background Despite conflicting results on the use of hormone replacement therapy (HRT there is no doubt that many women benefit from it. Women using HRT are known to be more health conscious in general with putative positive implications in the mouth. However, we observed recently in our cohort hardly any difference in oral health status between HRT-users and non-users. There are only a few studies about HRT and oral microbiota. We hypothesized that counts of periodontal micro-organisms are lower in health-conscious HRT-users than non-users. Methods Two-year open follow-up study was conducted on originally 200 HRT-users and 200 non-users from age cohorts of 50-58 years. After clinical examination pooled subgingival plaque samples were taken for polymerase chain reaction analyses. The results of finally 135 women meeting the inclusion criteria were analyzed with cross-tabulation and chi-square test. Explanatory factors were studied by step-wise logistic regression analysis. Results In HRT group, the numbers of positive samples for Porphyromonas gingivalis (P. gingivalis, p Prevotella intermedia (P. intermedia, p Tannerella forsythia (T. forsythia, p P. gingivalis (p T. forsythia (p Conclusion Although use of HRT did not correlate with periodontal health status, HRT led to decreasing numbers of positive samples of the periodontal pathogens P. gingivalis and T. forsythia. Further studies with longer observation time are needed to observe the clinical relevance of the results.

  7. Doença periodontal em mulheres na pós-menopausa e sua relação com a osteoporose Periodontal disease in women in post-menopause and its relationship with osteoporosis

    Directory of Open Access Journals (Sweden)

    Lívia de Almeida Barros Bertulucci

    2012-12-01

    Full Text Available OBJETIVO: Verificar a relação entre periodontite e osteoporose em um estudo caso-controle sobre a condição periodontal das mulheres na pós-menopausa. MÉTODOS: A amostra foi composta por 99 mulheres na pós-menopausa, divididas em três grupos: osso normal (Gn, osteopenia (Gpenia e osteoporose (Gporose, com 45, 31 e 23 casos, respectivamente. A categorização da massa óssea foi aferida pela absorciometria de dupla emissão com raios X na área lombar (L2 - L4, e pela avaliação da densidade mineral óssea. Os índices de nível de inserção clínica (NIC, sangramento gengival (IG, de placa (IP e profundidade de sondagem (PS foram obtidos de todas as participantes, por apenas um examinador. Foi utilizado o programa BioEstat 2.0 para análise dos dados com os testes paramétricos análise de variância (ANOVA e teste de Bonferroni, empregando-se o nível de significância de 5%. RESULTADOS: O grupo de mulheres com osteoporose apresentou o maior percentual de presença da doença periodontal, com maior média do NIC (2,6±0,4 mm, assim como PS (2,8±0,6 mm, IG (72,8±25,9 mm e IP (72,9±24,2 mm. Após a realização do tratamento estatístico, observou-se que houve diferença significativa para a situação periodontal, principalmente entre os grupos Gn e Gporose (p=0,01 e entre os grupos Gpenia e Gporose (p=0,03. CONCLUSÃO: A osteoporose pode ter uma influência na condição periodontal, por haver relação entre periodontite e osteoporose em mulheres na pós-menopausa.PURPOSE: To investigate the relationship between periodontitis and osteoporosis, using a case-control study about periodontal status of postmenopausal women. METHODS: A total of 99 postmenopausal women were divided into three groups: normal bone (Gn, n=45, osteopenia (Gpenia, n=31 and osteoporosis (Gporosis, n=23. The categorization of bone mass was measured by dual energy absorptiometry with X-rays in the lumbar spine (L2 - L4, by assessing bone mineral density. Clinical

  8. Comparison of clinical semi-quantitative assessment of muscle fat infiltration with quantitative assessment using chemical shift-based water/fat separation in MR studies of the calf of post-menopausal women

    Energy Technology Data Exchange (ETDEWEB)

    Alizai, Hamza; Nardo, Lorenzo; Karampinos, Dimitrios C.; Joseph, Gabby B.; Yap, Samuel P.; Baum, Thomas; Krug, Roland; Majumdar, Sharmila; Link, Thomas M. [University of California, San Francisco, Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, San Francisco, CA (United States)

    2012-07-15

    The goal of this study was to compare the semi-quantitative Goutallier classification for fat infiltration with quantitative fat-fraction derived from a magnetic resonance imaging (MRI) chemical shift-based water/fat separation technique. Sixty-two women (age 61 {+-} 6 years), 27 of whom had diabetes, underwent MRI of the calf using a T1-weighted fast spin-echo sequence and a six-echo spoiled gradient-echo sequence at 3 T. Water/fat images and fat fraction maps were reconstructed using the IDEAL algorithm with T2* correction and a multi-peak model for the fat spectrum. Two radiologists scored fat infiltration on the T1-weighted images using the Goutallier classification in six muscle compartments. Spearman correlations between the Goutallier grades and the fat fraction were calculated; in addition, intra-observer and inter-observer agreement were calculated. A significant correlation between the clinical grading and the fat fraction values was found for all muscle compartments (P < 0.0001, R values ranging from 0.79 to 0.88). Goutallier grades 0-4 had a fat fraction ranging from 3.5 to 19%. Intra-observer and inter-observer agreement values of 0.83 and 0.81 were calculated for the semi-quantitative grading. Semi-quantitative grading of intramuscular fat and quantitative fat fraction were significantly correlated and both techniques had excellent reproducibility. However, the clinical grading was found to overestimate muscle fat. (orig.)

  9. Estudo de custo-efetividade do anastrozol adjuvante no câncer de mama em mulheres pós-menopausa Cost-effectiveness analysis of adjuvant anastrozol in post-menopausal women with breast cancer

    Directory of Open Access Journals (Sweden)

    Andre Deeke Sasse

    2009-01-01

    Full Text Available OBJETIVOS: Análise econômica com dados nacionais sobre a possível incorporação do anastrozol como terapia adjuvante hormonal no câncer de mama em pacientes pós-menopausa. MÉTODOS: Foi feita estimativa de custo-efetividade no tratamento adjuvante do câncer de mama, em mulheres pós-menopausa, do anastrozol versus tamoxifeno em três perspectivas: do paciente, de planos de saúde e do governo. Modelo de Markov foi desenvolvido utilizando dados extraídos de publicação do estudo ATAC após seguimento de 100 meses, com projeção de desfechos em 25 anos para uma coorte hipotética de 1000 pacientes com câncer de mama pós-menopausa no Brasil. Dados de utilização de recursos e custos associados foram obtidos de fontes preestabelecidas e de opinião de especialistas. O custo associado aos tratamentos foi extraído separadamente, dependendo do ponto de vista estudado. O benefício foi inserido no modelo para obtenção do custo por ano de vida ganho ajustado pela qualidade (QALY. RESULTADOS: Extrapolando benefícios encontrados para 25 anos de seguimento, o anastrozol, em relação ao tamoxifeno, resultou numa estimativa de ganho de 0,29 QALY. A razão de custo-efetividade por QALY ganho dependeu da perspectiva utilizada. Houve incremento de R$ 32.403,00/QALY no ponto de vista do SUS; de R$ 32.230,00/QALY no dos planos de saúde; e de R$ 55.270,00/QALY no das pacientes. CONCLUSÃO: O benefício encontrado no uso do anastrozol adjuvante em pacientes com câncer de mama operado na pós-menopausa está associado a grandes diferenças na razão de custo-efetividade, dependendo da perspectiva utilizada para o cálculo. Comparando com parâmetros usualmente aceitos pela OMS, o incremento é aceitável sob a perspectiva do SUS e dos planos de saúde, mas não sob a ótica do paciente.OBJECTIVES: Carry out an economic analysis of the incorporation of anastrozole as adjuvant hormone therapy in postmenopausal women with breast cancer in a Brazilian

  10. Proteomics of muscle chronological ageing in post-menopausal women

    NARCIS (Netherlands)

    Gueugneau, M.; Coudy, C.; Gourbeyre, O.; Chambon, C.; Combaret, L.; Polge, C.; Tailandier, D.; Attaix, D.; Friguet, B.; Maier, A.B.; Butler-Browne, G.; Bechet, D.

    2014-01-01

    Background: Muscle ageing contributes to both loss of functional autonomy and increased morbidity. Muscle atrophy accelerates after 50 years of age, but the mechanisms involved are complex and likely result from the alteration of a variety of interrelated functions. In order to better understand the

  11. Treating osteoporosis in post-menopausal women: a case approach.

    Science.gov (United States)

    Keller, Michael I

    2004-10-01

    We now have several agents of different classes for treating postmenopausal osteoporosis. In this paper, a case report serves as the focus for a discussion of the risk factors for postmenopausal osteoporosis and of the available therapies.

  12. Why Do Only Some Women Develop Post Menopausal Osteoporosis

    Science.gov (United States)

    2016-03-01

    The decrease of soluble RAGE levels in rheumatoid arthritis patients following hormone replacement therapy is associated with increased bone mineral...effects of the Maillard reaction on the physical properties and cell interactions of collagen. Pathologie biologie, 54(7), 387-395. doi: 10.1016

  13. Efficacy of risedronate in a post-menopausal woman affected by osteoporosis and inflammatory bowel disease

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    Stefano Palomba

    2010-06-01

    Full Text Available Post-menopausal osteoporosis is a skeletal disease that can be asymptomatic and is sometimes underdiagnosed and undertreated. Post-menopausal osteoporosis can be associated with fractures and consequent impaired quality of life and increase of health care costs. Bisphosphonates are a therapeutic choice, because they proved to be effective in preventing bone loss. The current case report shows the efficacy of six-month risedronate administration in a post-menopausal woman affected by osteoporosis and inflammatory bowel disease in reducing biochemical bone turnover markers and increasing bone mineral density.

  14. Migraine in the post-menopausal period is associated with higher levels of mood disorders, disability, and more menopausal symptoms

    Directory of Open Access Journals (Sweden)

    Paula Carturan

    Full Text Available ABSTRACT Objective To assess the prevalence of headache in post-menopausal women. Methods Women attending gynecology outpatient services in the coastal region of the state of Sao Paulo, Brazil were invited to participate in this study. Only those with non-surgical menopause and no hormone replacement therapy were included. Prevalence and characterization of headaches were assessed, as well as the burden of migraine, traits of anxiety and depression, and menopausal symptomatology. Results One hundred and three women were included in the study. Migraine affected 14.7% of them. Some previous type of headache was reported by 86.2% of the women, most of whom improved during menopause but still presented with headache attacks. There was a correlation between higher migraine disability and depressive traits. Conclusions Many women believe that their headaches, particularly migraine, will end after menopause. This is, unfortunately, not the case for many of them.

  15. Comparison of post menopausal voice changes across professional and non-professional users of the voice

    Directory of Open Access Journals (Sweden)

    Pallavi Vishwas Sovani

    2010-12-01

    Full Text Available Menopause effects a permanent change in certain body functions, one of them being voice. Moreover, if the voice is used continuously as a part of one’s occupation, this may further impact postmenopausal voice changes. The present study investigated the impact of menopause and professional voice use, and their interaction effect, on the voice. 92 women were classified into reproductive (52 and postmenopausal (40. Each group was divided into Level II (teachers and Level IV (clerks of Koufman and Isaacson’s (1991 classification. Acoustic parameters were analyzed using the VisiPitch III software. Aerodynamic parameters were manually calculated. The VHI (Voice Handicap Index was also included to improve the face validity of the study. Results suggest that Fo, SFo and MPT reduce post menopause while NHR and VTI increase. Some changes are accelerated in teachers as compared to clerks while some are decelerated. VHI scores of teachers are significantly greater than clerks, though not significantly different across menopause. Thus the presence or absence of voice use in one’s profession differentially affects postmenopausal changes. The study has implications in improving the condition of teachers in India, developing norms for menopausal changes and modifying allowable limits for voice recognition systems in future.

  16. Variable aromatase inhibitor plasma concentrations do not correlate with circulating estrogen concentrations in post-menopausal breast cancer patients.

    Science.gov (United States)

    Hertz, Daniel L; Speth, Kelly A; Kidwell, Kelley M; Gersch, Christina L; Desta, Zeruesenay; Storniolo, Anna Maria; Stearns, Vered; Skaar, Todd C; Hayes, Daniel F; Henry, N Lynn; Rae, James M

    2017-10-01

    The aromatase inhibitors (AI) exemestane (EXE), letrozole (LET), and anastrozole suppress estrogen biosynthesis, and are effective treatments for estrogen receptor (ER)-positive breast cancer. Prior work suggests that anastrozole blood concentrations are associated with the magnitude of estrogen suppression. The objective of this study was to determine whether the magnitude of estrogen suppression, as determined by plasma estradiol (E2) concentrations, in EXE or LET treated patients is associated with plasma AI concentrations. Five hundred post-menopausal women with ER-positive breast cancer were enrolled in the prospective Exemestane and Letrozole Pharmacogenetic (ELPh) Study conducted by the COnsortium on BReast cancer phArmacogomics (COBRA) and randomly assigned to either drug. Estrogen concentrations were measured at baseline and after 3 months of AI treatment and drug concentrations were measured after 1 or 3 months. EXE or LET concentrations were compared with 3-month E2 concentration or the change from baseline to 3 months using several complementary statistical procedures. Four-hundred patients with on-treatment E2 and AI concentrations were evaluable (EXE n = 200, LET n = 200). Thirty (7.6%) patients (EXE n = 13, LET n = 17) had 3-month E2 concentrations above the lower limit of quantification (LLOQ) (median: 4.75; range: 1.42-63.8 pg/mL). EXE and LET concentrations were not associated with on-treatment E2 concentrations or changes in E2 concentrations from baseline (all p > 0.05). Steady-state plasma AI concentrations do not explain variability in E2 suppression in post-menopausal women receiving EXE or LET therapy, in contrast with prior evidence in anastrozole treated patients.

  17. Single-nucleotide polymorphisms in the P2X7 receptor gene are associated with post-menopausal bone loss and vertebral fractures

    DEFF Research Database (Denmark)

    Rye Jørgensen, Niklas; Husted, Lise Bjerre; Skarratt, Kristen K

    2012-01-01

    to bone mass and fracture incidence in post-menopausal women. A total of 1694 women (aged 45-58) participating in the Danish Osteoporosis Prevention Study were genotyped for 12 functional P2X7 receptor variants. Bone mineral density was determined at baseline and after 10 years. In addition, vertebral...... had increased bone loss. In contrast, the Gln460Arg polymorphism was associated with protection against bone loss. The Ala348Thr polymorphism was associated with a lower vertebral fracture incidence 10 years after menopause. Finally, we developed a risk model, which integrated P2RX7 genotypes. Using...

  18. A study of post-menopausal breast abscesses in West Africa ...

    African Journals Online (AJOL)

    Results: Their ages ranged from 11 to 78 years, averaged 40.5 years and peaked between 31 and 40 years. Breast abscess was seen in 53 of them. Conclusion: Breast abscess is common (22.3%) in post-menopausal Igbo patients aged over 50 years. Keywords: fibroadenoma, tumour, mammary, dysplasia, galactocele.

  19. A radioimmunoassay for equilin in post-menopausal plasma: plasma levels of equilin determined after oral administration of conjugated equine oestrogens (Premarin)

    International Nuclear Information System (INIS)

    Morgan, M.R.A.; Whittaker, P.G.; Fuller, B.P.; Dean, P.D.G.

    1980-01-01

    Preparations containing equilin are widely used in hormone therapy at the menopause. No suitable routine assay exists for this steroid. Antisera have been raised to equilin-3-hemisuccinyl-bovine serum albumin, and have been found to be highly specific for equilin. A direct sensitive assay for this steroid in post-menopausal plasma has been established. The implications of the cross-reaction data for the synthesis of oestrogen immunogens are discussed. Equilin has been assayed in samples obtained from oophorectomised women receiving conjugated equine oestrogens (Premarin). (author)

  20. Identifying predictive motor factors for falls in post-menopausal breast cancer survivors.

    Directory of Open Access Journals (Sweden)

    Marek Zak

    Full Text Available Breast cancer treatment, including radical surgery, is also pursued as late as the 7th - 8th decade of women's lives. Standard physical rehabilitation procedures offered to those women are predominantly focused on attenuating specific functional deficits of the upper limb and trunk. Seldom do they entail any regimens specifically aimed at recovering overall functionality, and reducing exposure to falls-risk. The study aimed to assess potential interrelationships between the self-reported falls, individual functional capabilities and appreciably reducing exposure to falls-risk in a group of post-menopausal, post-surgical breast cancer survivors.The study recruited 102 women (aged 65-79; mean age 70.2, post-surgical breast cancer survivors. The subjects were stratified by age into three groups: Group 1 (65-69 years; Group 2 (70-74 years, and Group 3 (75-79 years. Individual functional capabilities were assessed with Eight-foot up & go test (8UG, chair stand test (CST, and 2-minute step test (2ST. Tinetti POMA test was applied to assess gait and balance disorders. Self-reported falls in the past year were ascertained through a questionnaire.Assessment of individual aerobic endurance (2ST also demonstrated a clear deficit in the mean scores category in all respective age sub-groups, as compared against the reference values. The deficits ranged from 4.86 to 15.90 steps less than the normative values; the oldest subjects demonstrating the largest deficit. The aerobic endurance tests results significantly impacted the ultimate assessment of an individual falls-risk in the oldest group. The analysis of the number of falls sustained within the recent year indicated that 43.67% of the subjects fell victim of such incidents.An individual exposure to falls-risk was found to be appreciably more dependent upon individual aerobic endurance rather than overall strength of the lower part of the body in the breast cancer survivors over 75.

  1. EVALUATION OF THE EFFECTS OF HORMONAL SUBSTITUTION THERAPY UPON THE PERIODONTAL STATUS IN FEMALE PATIENTS DURING PRE- AND POST-MENOPAUSE

    Directory of Open Access Journals (Sweden)

    Irina Ursărescu

    2012-12-01

    Full Text Available Scope of the study. To evaluate the bone mass loss in women, during menopause and post-menopause (a period associated with a deficit of estrogen and the effect of the substitution hormonal therapy. Materials and method. The experimental group included 46 female subjects, evaluated in the beginning of menopause and also at post-menopause, with and without hormonal substitution therapy (in the moment of the consultation. The periodontal clinical (probing depth, CPITN, index of gingival recession, index of dental mobility, index of furcation involvement and radiological indices were evaluated, on following the evolution of the periodontal status from the first consultation in the 3 years. Results. It has been demonstrated that, in patients with periodontitis, early onset menopause and the estrogen deficit, the frequency of gingival bleeding on probing and the clinical loss of attachment were higher, comparatively with the patients having followed a hormonal substitution therapy. Discussion. Apparently, estrogen has a protecting effect upon the periodontium and also upon the severity of the periodontal disease. More than that, the alveolar bone that may be affected by osteoporosis also contributes to the benefic effects of HT, in preventing osteoporosis, the risk of suffering the negative effects of edentation in postmenopause women who receive HT being lower. Conclusions. The present study evidenced the increased incidence of both gingivitis and periodontal pathology, of the ratio of edentation in women at menopause, while the absence of the hormonal substitution therapy seems to be associated with the severity of the periodontal disease.

  2. Mechanisms underlying social inequality in post-menopausal breast cancer.

    Science.gov (United States)

    Hvidtfeldt, Ulla Arthur

    2014-10-01

    This thesis is based on studies conducted in the period 2010-2014 at Department of Public Health, University of Copenhagen and at Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York. The results are presented in three scientific papers and a synopsis. The main objective of the thesis was to determine mechanisms underlying social inequality (defined by educational level) in postmenopausal breast cancer (BC) by addressing mediating effects through hormone therapy (HT) use, BMI, lifestyle and reproductive factors. The results of previous studies suggest that the higher risk of postmenopausal BC among women of high socioeconomic position (SEP) may be explained by reproductive factors and health behaviors. Women of higher SEP generally have fewer children and give birth at older ages than women of low SEP, and these factors have been found to affect the risk of BC - probably through altered hormone levels. Adverse effects on BC risk have also been documented for modifiable health behaviors that may affect hormone levels, such as alcohol consumption, high BMI, physical inactivity, and HT use. Alcohol consumption and HT use are likewise more common among women of higher SEP. The analyses were based on the Social Inequality in Cancer (SIC) cohort and a subsample of the Women's Health Initiative Observational Study (WHI-OS). The SIC cohort was derived by pooling 6 individual studies from the Copenhagen area including 33,562 women (1,733 BC cases) aged 50-70 years at baseline. The subsample of WHI-OS consisted of two case-cohort studies with measurements of endogenous estradiol (N = 1,601) and insulin (N = 791). Assessment of mediation often relies on comparing multiplicative models with and without the potential mediator. Such approaches provide potentially biased results, because they do not account for mediator-outcome confounding, exposure-dependent mediator-outcome confounding, exposure-mediator interaction and interactions

  3. study on the serum levels of E2, IL-6 and IGF-I in patients with post-menopausal osteoporosis (PMO)

    International Nuclear Information System (INIS)

    Lv Kuan; Liu Chunyu; Lu Yingju

    2006-01-01

    Objective: To study the changes of serum levels of E 2 , IL-6, IGF-I in patients with post-menopausal osteoporosis (PMO). Methods: Serum levels of E 2 (with CLIA), IL-6, IGF-I, BGP (with RIA) were measured in the following subjects: (1) 32 patients with PMO (2) 32 post-menopausal women without PMO and (3) 30 pre-menopausal controls. Serum P, Ca and AKP levels were also determined. Results: As a whole, serum levels of IL -6 in postmenopausal women were higher than those in controls. Levels in subjects with PMO were significantly higher than those without PMO (P 2 and BMD index (r=-0. 587, - 0. 438 respectively, P 2 and BMD index (r=0.569, 0.433 respectively, P 2 levels will in someway promote the expression of IL-6 ( osteoclastic) and reduce the expression of IGF-I (osteoclastic), resulting in lessening of bone mass. HRT, despite of the controversy over cardio-vascalar safety, is beneficial for osteoporosis. (authors)

  4. Inflammation-induced bone remodeling in periodontal disease and the influence of post-menopausal osteoporosis.

    Science.gov (United States)

    Lerner, U H

    2006-07-01

    During physiological conditions, the skeleton is remodeled in so-called bone multi-cellular units. Such units have been estimated to exist at 1-2 x 10(6) sites in the adult skeleton. The number and activities of these units are regulated by a variety of hormones and cytokines. In post-menopausal osteoporosis, lack of estrogen leads to increased numbers of bone multi-cellular units and to uncoupling of bone formation and bone resorption, resulting in too little bone laid down by osteoblasts compared with the amount of bone resorbed by osteoclasts. Inflammatory processes in the vicinity of the skeleton, e.g., marginal and apical periodontitis, will affect the remodeling of the nearby bone tissue in such a way that, in most patients, the amount of bone resorbed exceeds that being formed, resulting in net bone loss (inflammation-induced osteolysis). In some patients, however, inflammation-induced bone formation exceeds resorption, and a sclerotic lesion will develop. The cellular and molecular pathogenetic mechanisms in inflammation-induced osteolysis and sclerosis are discussed in the present review. The cytokines believed to be involved in inflammation-induced remodeling are very similar to those suggested to play crucial roles in post-menopausal osteoporosis. In patients with periodontal disease and concomitant post-menopausal osteoporosis, the possibility exists that the lack of estrogen influences the activities of bone cells and immune cells in such a way that the progression of alveolar bone loss will be enhanced. In the present paper, the evidence for and against this hypothesis is presented.

  5. Targeted inhibition of sclerostin for post-menopausal osteoporosis therapy: A critical assessment of the mechanism of action.

    Science.gov (United States)

    Bhattacharyya, Sharmistha; Pal, Subhashis; Chattopadhyay, Naibedya

    2018-05-05

    Promising news in the treatment of osteoporosis is that sequestering sclerostin from circulation with antibodies stimulates robust bone formation. Pre-clinical studies on rodents and monkeys have confirmed that treatment with anti-sclerostin monoclonal antibody (Scl-Ab) increases bone mass, improves bone strength and enhances fracture repair. Clinical trials show that bone gain (anabolic effect) is transient and are primarily at central (spine and hips) than peripheral (wrist) sites. Interestingly Scl-Ab also inhibited bone resorption. Thus Scl-Ab is being regarded as the pharmacologic agent with dual properties - stimulating bone formation and decreasing bone resorption. Sclerostin neutralization transiently increases bone formation markers in post-menopausal women and like parathyroid hormone (PTH) activates osteoblasts and lining cells resulting in bone anabolic effect. However, unlike PTH, sclerostin antibody also decreases bone resorption (anti-catabolic). Although, the U.S. Food and Drug Administration have accepted the Biologics License Application for one of the monoclonal antibodies against sclerostin (romosozumab) for review, many questions remain before romosozumab can be introduced as a skeletal anabolic agent to clinical practice. For example, neutralizing sclerostin alters calcium homeostasis and increases PTH. In addition, sclerostin depletion in preclinical studies has been reported to severely compromises B cell depletion in bone marrow. We have reviewed the currently available evidences that support the use of sclerostin antibody in treating osteoporosis and compare its efficacy and mechanism of action with the currently available anabolic drug, human PTH. Copyright © 2018 Elsevier B.V. All rights reserved.

  6. Do Current Fortification and Supplementation Programs Assure Adequate Intake of Fat-Soluble Vitamins in Belgian Infants, Toddlers, Pregnant Women, and Lactating Women?

    Directory of Open Access Journals (Sweden)

    Isabelle Moyersoen

    2018-02-01

    Full Text Available Adequate intakes of fat-soluble vitamins are essential to support the growth and development of the foetus, the neonate, and the young child. By means of an online self-administered frequency questionnaire, this study aimed to evaluate the intake of vitamins A, D, E, and K in Belgian infants (n = 455, toddlers (n = 265, pregnant women (n = 161, and lactating women (n = 165. The contribution of foods, fortified foods, and supplements on the total intake was quantified. 5% of toddlers, 16% of pregnant women, and 35% of lactating women had an inadequate vitamin A intake. Conversely, excessive vitamin A intakes were associated with consumption of liver (products. Furthermore, 22% of infants were at risk for inadequate vitamin D intake due to the lack of prophylaxis, while consumption of highly dosed supplements posed a risk for excessive intakes in 6%–26% of infants. Vitamin D intake in pregnant women and lactating women was inadequate (median of 51%, respectively, 60% of the adequate intake. In all groups, the risk for inadequate intake of vitamin E and K was low. Contribution of fortified foods to vitamin A, D, E, and K intake was minor, except in toddlers. National fortification strategies should be investigated as an alternative or additional strategy to prevent vitamin D and A deficiency. There is a need to revise and set uniform supplement recommendations. Finally, non-users of vitamin D prophylaxis need to be identified for targeted treatment.

  7. Lifetime moderate-to-vigorous physical activity and ER/PR/HER-defined post-menopausal breast cancer risk.

    Science.gov (United States)

    Shi, Joy; Kobayashi, Lindsay C; Grundy, Anne; Richardson, Harriet; SenGupta, Sandip K; Lohrisch, Caroline A; Spinelli, John J; Aronson, Kristan J

    2017-08-01

    To assess the relationship of moderate-to-vigorous physical activity (MVPA) in leisure-time, household, and occupational domains across the total lifetime and in four age periods with breast cancer risk, as defined by estrogen receptor (ER)/progesterone receptor (PR) status and ER/PR/human epidermal growth factor-2 (HER2) status, among post-menopausal women. Data were from 692 women with incident breast cancer and 644 controls in the Canadian Breast Cancer Study, a case-control study of women aged 40-80 years in British Columbia and Ontario. Mean metabolic equivalent (MET)-hours/week for questionnaire-assessed leisure-time, household, and occupational MVPA were calculated for the total lifetime and four age periods (12-17, 18-34, 45-49, and ≥50 years). Odds ratios (ORs) for the relationships between domain-specific MVPA at each lifetime period and risks of ER/PR-defined and ER/PR/HER2-defined breast cancers were estimated using polytomous logistic regression. Trend tests for dose-response relationships were calculated for the ORs across increasing tertiles of mean MET-hours/week of MVPA. Total lifetime leisure-time MVPA was associated with reduced risk of ER-/PR- breast cancer in a dose-response fashion (p trend  = 0.014). In contrast, total lifetime household MVPA was associated with reduced risk of ER+ and/or PR+ breast cancer (p trend  PR-/HER2- breast cancers and lifetime household MVPA was associated with reduced risk of ER+ and/or PR+ breast cancer, regardless of HER2 status.

  8. Long-term effect of exercise on bone mineral density and body composition in post-menopausal ex-elite athletes: a retrospective study.

    Science.gov (United States)

    Andreoli, A; Celi, M; Volpe, S L; Sorge, R; Tarantino, U

    2012-01-01

    The aim of this retrospective study was to determine the long-term effect of exercise on bone mineral density (BMD), bone mineral content (BMC) and body composition (BC) in post-menopausal women who were elite athletes during their youth compared with sedentary controls. It is a retrospective study and carried out in an outpatient clinic. A total of 48 post-menopausal women (54-73 years of age) were enrolled. Ex-elite athletes with long-term (>20 years) histories of significant training and performance were divided into two groups: weight-bearing sports (runners, n=12) and non-weight-bearing sports (swimmers, n=12). The athletes were age matched with sedentary controls (n=24). BMD, BMC and BC were measured using dual-energy X-ray absorptiometry. Healthcare and sport activity histories were evaluated using a questionnaire. No significant differences were found with regard to body weight, height, body mass index and hours of activity between the two groups of athletes. There were no significant differences in activity levels between athletes and controls at the time of this study. BMD and BMC were not significantly different between athletes; they were significantly higher in athletes than in controls (Pex-athletes did not significantly differ in BC, left and right lean arm mass and arm BMD were significantly higher in swimmers than in runners (P<0.0001). The high level of physical activity observed in female athletes is associated with improved muscle mass, BMD and BMC, and physical activity during youth seems to have a beneficial effect on bone mass and helps to prevent bone loss due to aging.

  9. Cardiorenal disease connection during post-menopause: The protective role of estrogen in uremic toxins induced microvascular dysfunction

    NARCIS (Netherlands)

    Pei, J. (Jiayi); M. Harakalova (Magdalena); H.M. den Ruijter (Hester ); G. Pasterkamp (Gerard); D.J.G.M. Duncker (Dirk); M.C. Verhaar (Marianne); F.W. Asselbergs (Folkert); C. Cheng (Caroline)

    2017-01-01

    textabstractFemale gender, post-menopause, chronic kidney disease (CKD) and (CKD linked) microvascular disease are important risk factors for developing heart failure with preserved ejection fraction (HFpEF). Enhancing our understanding of the interrelation between these risk factors could greatly

  10. Cardiorenal disease connection during post-menopause : The protective role of estrogen in uremic toxins induced microvascular dysfunction

    NARCIS (Netherlands)

    Pei, Jiayi; Harakalova, Magdalena; den Ruijter, Hester; Pasterkamp, Gerard; Duncker, Dirk J.; Verhaar, Marianne C.; Asselbergs, Folkert W.; Cheng, Caroline

    2017-01-01

    Female gender, post-menopause, chronic kidney disease (CKD) and (CKD linked) microvascular disease are important risk factors for developing heart failure with preserved ejection fraction (HFpEF). Enhancing our understanding of the interrelation between these risk factors could greatly benefit the

  11. A histerectomia simples realizada no menacme e a densidade mineral óssea da mulher na pós-menopausa Pre-menopausal simple hysterectomy and post-menopausal female bone mineral density

    Directory of Open Access Journals (Sweden)

    João Daniel Hobeika

    2002-12-01

    Full Text Available O objetivo foi avaliar a densidade mineral óssea de mulheres na pós-menopausa, com o antecedente de histerectomia com conservação ovariana bilateral, realizada no menacme, comparadas a um grupo de mulheres com menopausa natural, não histerectomizadas. Tratou-se de um estudo de corte transversal, com trinta mulheres na pós-menopausa e histerectomizadas no menacme e 102 mulheres menopausadas naturalmente, comparando-se as respectivas densitometrias ósseas, em nível do fêmur e coluna lombar. A análise mostrou que as variáveis idade e índice de massa corporal estavam fortemente associadas à densidade mineral óssea do fêmur e da coluna lombar, sendo o índice de massa corporal diretamente e a idade inversamente associados. Posteriormente, as trinta mulheres histerectomizadas, foram pareadas por idade e índice de massa corporal, com trinta mulheres não-histerectomizadas, não apresentando diferenças estatisticamente significantes da densidade mineral óssea. Esses resultados sugerem que a histerectomia com conservação ovariana bilateral, realizada em mulheres no menacme, não parece ocasionar redução adicional da massa óssea, quando avaliadas na pós-menopausa.This study aimed to evaluate the bone mineral density (BMD of post-menopausal women with previous pre-menopausal hysterectomy including bilateral ovarian conservation compared to a group of non-hysterectomized women with natural menopause. Data from a cross-sectional study of 30 pre-menopausally hysterectomized women evaluated in the post-menopause were compared with 102 naturally post-menopausal women, analyzing their respective bone densitometry, measuring the femoral and lumbar spinal BMD. Multiple regression analysis of the 132 women showed that age and body mass index (BMI were heavily associated with femoral and lumbar spinal BMD, BMI directly associated, and age inversely associated with BMD. In addition, 30 hysterectomized women were matched by age and BMI to the

  12. Resveratrol, tryptophanum, glycine and vitamin E: a nutraceutical approach to sleep disturbance and irritability in peri- and post-menopause.

    Science.gov (United States)

    Parazzini, F

    2015-02-01

    The climacteric syndrome is characterized by several symptoms: hot flashes are the most common and reported by about 70% of peri- post-menopausal women. Sleep disorders, particularly decreased sleep quality, and irritability are also commonly reported. There is a clinical and epidemiological relationship between these symptoms. Common biological mechanisms may explain in part the relationship between hot flushes, sleep disorders and irritability. For example, withdrawal of hormones causes change in the serotonin levels. Tryptophan is an essential amino acid. it is the precursor for the serotonin synthesis and is naturally found in food such as turkey, cheese, and nuts. The serotonergic system is implicated in sleep, mood, and hot flashes. Glycine is an amino acid found mainly in protein-rich food such as meat, fish, dairy products, cheese and vegetables. It is an inhibitory neurotransmitter in the central nervous system. Studies have shown that glycine can promote a deeper level of sleep. Resveratrol has a similar chemical structure to the diethylstilbestrol and 17-beta estradiol and acts as a phytoestrogen. Resveratrol at doses of 3-10 micromoles inhibited the estradiol-estrogen receptor binding and showed an estrogen-like activity. Vitamin E is found naturally in some food and available as a dietary supplement. It has an antioxidant activity. It has been suggested that the oxidative stress may also play a role in sleep disorders. Some studies have shown protective effect of vitamins E on sleep quality. In conclusion, hot flashes, sleep disturbances and mood disorders may represent a continuum in the climacteric syndrome, which recognize in the hormonal changes and the neurotrasmettitors level alteration a potential common pathway. The nutraceutical approach may be useful in a preventive perspective. Among the large choice of functional food available, the combination of resveratrol, tryptophanum, glycine and vitamin E may represent an interesting opportunity in

  13. Analysis of Amygdalar-Cortical Network Covariance During Pre- versus Post-menopausal Estrogen Levels: Potential Relevance to Resting State Networks, Mood, and Cognition

    Science.gov (United States)

    Ottowitz, William E.; Derro, David; Dougherty, Darin D.; Lindquist, Martin A.; Fischman, Alan J.; Hall, Janet E.

    2014-01-01

    Objectives 1.) Expand the scope of neuroendocrine applications of functional neuroimaging techniques. 2.) Compare the covariance of amygdalar activity with that of the rest of the brain during pre- and post-menopausal levels of estrogen (E2). Based on the distribution of cortical E2 receptors and the neocortical regions where E2 has been shown to preferentially accumulate, we predict that E2 infusion will increase covariance of amygdalar activity with that of the temporal and frontal cortices. Design This basic physiology study employed a within-subject design. All participants were post-menopausal women (n =7). Analysis of covariance between whole brain and amygdalar regional cerebral glucose consumption (CMRglc) was conducted in a voxel-wise manner by means of the basic regression option in SPM2 and was applied to FDG-PET scans acquired at baseline and after a 24 hour graded E2 infusion. Setting an academic medical center; Massachusetts General Hospital, Boston, Massachusetts. Results E2 levels (mean ± sem) were significantly greater at 24 hours (257.9 pg/mL ± 29.7) than at 0 hours (28.1 pg/mL ± 3.4). Right amygdalar CMRglc showed a significant covariance with activity of three different regions of the temporal cortex during E2 infusion, but none at baseline. In addition, right amygdalar CMRglc covaried with that of the right medial and superior frontal gyri only during E2 infusion. Conclusions In addition to suggesting changes in amygdalar-cortical network connectivity as a result of short-term E2 exposure, these analyses provide evidence that basic neuroendocrine research may benefit from further use of FDG-PET and other functional neuroimaging modalities for network level analyses. PMID:18766152

  14. Effect of Bisphosphonates on the Levels of Rankl and Opg in Gingival Crevicular Fluid of Patients With Periodontal Disease and Post-menopausal Osteoporosis.

    Science.gov (United States)

    Verde, María E; Bermejo, Daniela; Gruppi, Adriana; Grenón, Miriam

    2015-12-01

    The Receptor activator of nuclear factor-kappa B ligand (RANKL)/RANK/Osteoprotegerine (OPG) system has been proposed as essential for osteoclast biology and identified as key part in regulating the physiology and pathology of the skeletal system. The study of the RANKL/RANK/OPG system has increased the understanding of the mechanisms involved in the bone remodeling process, especially in postmenopausal osteoporosis and periodontal disease. Bisphosphonates have become the mainstay of the treatment and prevention of post-menopausal osteoporosis. They inhibit the formation and dissolution of calcium phosphate crystals in bone and also osteoclasts, thus reducing bone turnover.Current investigations relate osteoporosis with the appearance and progression of periodontal disease. Although the etiology of both is different, the bone loss present in both shares several characteristics. Thus, therapy used for osteoporosis can be considered of value in the treatment of periodontal disease. The aim of this study was to evaluate the levels of RANKL, OPG and their relationship in gingival crevicular fluid (GCF) in patients with periodontal disease and postmenopausal osteoporosis/ osteopenia in relation to consumption of bisphosphonates. We studied 66 periodontal active sites obtained from 17 post- menopausal women patients aged between 45-70 years old with osteoporosis/osteopenia and periodontal disease. GCF samples were collected using sterile filter paper strips. To determine the concentration of RANKL and OPG, a commercial ELISA assay was used. The values of RANKL, OPG and their ratio (RANKL/ OPG) were compared with Mann-Whitney U Test. The values of RANKL, OPG and their ratio obtained in patients with osteoporosis/osteopenia and periodontal disease with or without bisphosphonates treatment showed no differences. Bisphosphonates do not alter the concentration of RANKL and OPG and their ratio in the GCF of patients with osteoporosis/ osteopenia and periodontal disease

  15. Sintomas climatéricos e estado nutricional de mulheres na pós-menopausa usuárias e não usuárias de terapia hormonal Climacteric symptoms and nutritional status of women in post-menopause users and non-users of hormone therapy

    Directory of Open Access Journals (Sweden)

    Angela Andréia França Gravena

    2013-04-01

    Full Text Available OBJETIVO: Analisar os sintomas climatéricos e estado nutricional em mulheres na pós-menopausa, usuárias e não usuárias de terapia hormonal (TH. MÉTODOS: Estudo analítico, exploratório, tipo inquérito populacional domiciliar, realizado na área urbana do município de Maringá, Paraná, incluindo 456 mulheres com idade entre 45 e 69 anos, no período pós-menopausa. A coleta teve como base de referência os setores censitários urbanizados (368 do município, de acordo com o Censo Demográfico Brasileiro. Foi utilizada amostra aleatória simples proporcional às mulheres residentes em cada setor censitário e, por meio de visita domiciliar, aplicou-se um questionário e verificaram-se as medidas antropométricas e pressão arterial. Para avaliação dos sintomas climatéricos, foi utilizado o Índice Menopausal de Blatt e Kupperman. A variável desfecho foi o uso de TH. RESULTADOS: A média de idade foi de 58,7 anos. O excesso de peso esteve presente em 72,6% das mulheres e a obesidade abdominal em 81,4% delas. Sintomas climatéricos de intensidade leve foram evidenciados em 69,5% das mulheres. Apenas 18,4% das mulheres faziam uso de TH e eram, na sua maioria, brancas, não fumantes, sem comorbidades e sem companheiro. Usuárias de TH apresentaram menor frequência de excesso de peso e obesidade abdominal e tiveram menor prevalência de sintomas climatéricos de intensidade severa. CONCLUSÃO: O excesso de peso e a obesidade abdominal foram prevalentes na amostra estudada. Embora em menor número, as usuárias de TH apresentaram uma frequência menor de excesso de peso e sintomas climatéricos leves e intensos na pós-menopausa.PURPOSE: To analyze the climacteric symptoms, nutritional status and distribution of abdominal fat in postmenopausal women using or not hormone therapy. METHODS: exploratory analytical study of the population survey type in the urban area of Maringa, Parana, conducted on 456 postmenopausal women aged 45 to 69

  16. Increased number of endothelial progenitors in peripheral blood as a possible early marker of tumour growth in post-menopausal breast cancer patients.

    Science.gov (United States)

    Rhone, P; Ruszkowska-Ciastek, B; Celmer, M; Brkic, A; Bielawski, K; Boinska, J; Zarychta, E; Rosc, D

    2017-02-01

    The aim of the study was to evaluate the number of circulating endothelial progenitor cells (circulating EPCs) in the blood of patients diagnosed with breast cancer and to make an attempt at finding associations with the number of circulating EPCs and selected clinic-pathological factors; TNM and histological grading, molecular subtype of breast cancer, hormonal status, the expression of Ki-67 and the size of tumour. The study involved 96 Caucasian ethnicity post-menopausal women. Sixty-six women aged 48 - 63 (mean age 55) with breast cancer diagnosis without distant metastases (M0). The median value of the tumour diameter was 1.51 cm. The control group consisted of 30 healthy, non-smoking, post-menopausal women, mean age 49, range 44 - 54 years of age. The exclusion criteria for all the participants were hypertension, hyperlipidaemia, and hyperglycaemia, acute and chronic infection. With regard to the fresh blood samples the number of circulating endothelial progenitors was determined using flow cytometry. The fluorescence of 100,000 cells was measured during the analysis. Circulating EPCs were identified with the immune-phenotype CD45 - , CD34 + , CD133 + , CD31 + . A significantly higher number of circulating EPCs in the study group, as compared to the controls (P = 0.0001) and a significantly higher number of circulating EPCs in women over 60 with breast cancer than in the younger women (P = 0.0029) were reported. A positive correlation was noted between circulating EPCs and age as well as between circulating EPCs and HER-2 (P = 0.0231, P = 0.0414, respectively), and a negative correlation between circulating EPCs and histological grading of breast cancer (P = 0.0272). The study has shown a higher number of circulating EPCs in breast cancer patients, which indicates stimulation of neovascularization. Additionally, since bone morrow-derived circulating EPCs are more intensively mobilised in older and overweight breast cancer patients, we can speculate that more

  17. Análise de correspondência para avaliação do perfil de mulheres na pós-menopausa e o uso da terapia de reposição hormonal Correspondence analysis for the evaluation of women's profile during post-menopause and hormone replacement therapy

    Directory of Open Access Journals (Sweden)

    Renata Nunes Aranha

    2004-02-01

    Full Text Available Neste estudo ilustra-se a utilização da técnica de análise de correspondência na caracterização do perfil das usuárias e das não-usuárias da Terapia de Reposição Hormonal (TRH. Analisou-se dados seccionais de 195 mulheres com relato de menopausa natural, entre 2.240 participantes do Estudo Pró-Saúde (Rio de Janeiro. As mulheres não-usuárias da TRH apresentaram perfil mais desfavorável em relação às usuárias dessa terapia, por exemplo, ganho ponderal mais acentuado na vida adulta, idade mais avançada, menopausa mais tardia e menor nível de escolaridade. O uso desta ferramenta analítica deveria ser estimulada na área da saúde, em análises exploratórias das inter-relações entre um grande número de variáveis em populações de interesse.This study illustrates the use of correspondence analysis to identify distinct profiles characterizing hormone replacement therapy (HRT users and non-users, allowing the visualization of concurrent characteristics associated with this self-selection process. We analyzed cross-sectional information provided by 195 women reporting natural menopause, among 2,240 participants in the Pro-Saude Study (Rio de Janeiro, Brazil. Non-users had an unfavorable profile, including greater weight gain during adult life, older age, later menopause, and less schooling. This analytic tool should be used more extensively in public health research, in exploratory analyses of the relations among a large number of variables in key populations.

  18. Radiation Therapy in Treating Post-Menopausal Women With Early Stage Breast Cancer Undergoing Surgery

    Science.gov (United States)

    2017-06-07

    Ductal Breast Carcinoma In Situ; Estrogen Receptor Negative; Estrogen Receptor Positive; HER2/Neu Negative; Invasive Cribriform Breast Carcinoma; Invasive Ductal Carcinoma, Not Otherwise Specified; Lobular Breast Carcinoma In Situ; Mucinous Breast Carcinoma; Papillary Breast Carcinoma; Progesterone Receptor Positive; Stage I Breast Cancer; Stage II Breast Cancer; Stage IIIA Breast Cancer; Stage IIIC Breast Cancer; Tubular Breast Carcinoma

  19. Opinion of South African pre- and post-menopausal women on the ...

    African Journals Online (AJOL)

    Afrikaanse vroue, van beide ouderdoms- en rasgroepe, 'n positiewe opinie oor die gesondheidsvoordele van soja as HVT en verligter van menopousale simptome gehad het as oor soja se voordele om kardiovaskulêre siektes en osteoporose te ...

  20. Periodontal disease in women in post-menopause and its relationship with osteoporosis

    OpenAIRE

    Bertulucci, Lívia de Almeida Barros; Pereira, Flavia Maria Barros Guimarães; Oliveira, Ana Emília Figueiredo de; Brito, Luciane Maria Oliveira; Lopes, Fernanda Ferreira

    2012-01-01

    OBJETIVO: Verificar a relação entre periodontite e osteoporose em um estudo caso-controle sobre a condição periodontal das mulheres na pós-menopausa. MÉTODOS: A amostra foi composta por 99 mulheres na pós-menopausa, divididas em três grupos: osso normal (Gn), osteopenia (Gpenia) e osteoporose (Gporose), com 45, 31 e 23 casos, respectivamente. A categorização da massa óssea foi aferida pela absorciometria de dupla emissão com raios X na área lombar (L2 - L4), e pela avaliação da densidade mine...

  1. The efficacy and safety of vertebral fracture prevention therapies in post-menopausal osteoporosis treatment: Which therapies work best? a network meta-analysis.

    Science.gov (United States)

    Wang, G; Sui, L; Gai, P; Li, G; Qi, X; Jiang, X

    2017-07-01

    Osteoporosis has become an increasing concern for older people as it may potentially lead to osteoporotic fractures. This study is designed to assess the efficacy and safety of ten therapies for post-menopausal women using network meta-analysis. We conducted a systematic search in several databases, including PubMed and Embase. A random-effects model was employed and results were assessed by the odds ratio (OR) and corresponding 95% confidence intervals (CI). Furthermore, with respect to each outcome, each intervention was ranked according to the surface under the cumulative ranking curve (SUCRA) value. With respect to preventing new vertebral fractures (NVF), all ten drugs outperformed placebo, and etidronate proved to be the most effective treatment (OR 0.24, 95% CI 0.14 to 0.39). In addition, zoledronic acid and parathyroid hormone ranked higher compared with the other drugs. With respect to preventing clinical vertebral fractures (CVF), zoledronic acid proved to be the most effective drug (OR = 0.25, 95% CI 0.08 to 0.92), with denosumab as a desirable second option (OR = 0.48, 95% CI 0.22 to 0.96), when both were compared with placebo. As for adverse events (AE) and severe adverse events (SAE), no significant difference was observed. According to SUCRA, etidronate ranked first in preventing CVF; parathyroid hormone and zoledronic acid ranked highly in preventing NVF and CVF. Raloxifene was safe with a high rank in preventing AEs and SAEs though performed unsatisfactorily in efficacy. This study suggests that, taking efficacy and safety into account, parathyroid hormone and zoledronic acid had the highest probability of satisfactory performance in preventing osteoporotic fractures. Cite this article: G. Wang, L. Sui, P. Gai, G. Li, X. Qi, X. Jiang. The efficacy and safety of vertebral fracture prevention therapies in post-menopausal osteoporosis treatment: Which therapies work best? a network meta-analysis. Bone Joint Res 2017;6:452-463. DOI: 10

  2. Sedentary Lifestyle and High-Carbohydrate Intake are Associated with Low-Grade Chronic Inflammation in Post-Menopause: A Cross-sectional Study.

    Science.gov (United States)

    Alves, Bruna Cherubini; Silva, Thaís Rasia da; Spritzer, Poli Mara

    2016-07-01

    Introduction Cardiovascular disease (CVD) is the leading cause of death in post menopausal women, and inflammation is involved in the atherosclerosis process. Purpose to assess whether dietary pattern, metabolic profile, body composition and physical activity are associated with low-grade chronic inflammation according to high-sensitivity C-reactive protein (hs-CRP) levels in postmenopausal women. Methods ninety-five postmenopausal participants, with no evidence of clinical disease, underwent anthropometric, metabolic and hormonal assessments. Usual dietary intake was assessed with a validated food frequency questionnaire, habitual physical activity was measured with a digital pedometer, and body composition was estimated by bioelectrical impedance analysis. Patients with hs-CRP ≥10 mg/L or using hormone therapy in the last three months before the study were excluded from the analysis. Participants were stratified according to hs-CRP lower or ≥3 mg/L. Sedentary lifestyle was defined as walking fewer than 6 thousand steps a day. Two-tailed Student's t-test, Wilcoxon-Mann-Whitney U or Chi-square (χ(2)) test were used to compare differences between groups. A logistic regression model was used to estimate the odds ratio of variables for high hs-CRP. Results participants with hs-CRP ≥3 mg/L had higher body mass index (BMI), body fat percentage, waist circumference (WC), triglycerides, glucose, and homeostasis model assessment of insulin resistance (HOMA-IR) (p = 0.01 for all variables) than women with hs-CRP sedentary lifestyle (p sedentary lifestyle (4.7, 95% confidence interval [95%CI] 1.4-15.5) and carbohydrate intake (2.9, 95%CI 1.1-7.7). Conclusions sedentary lifestyle and high-carbohydrate intake were associated with low-grade chronic inflammation and cardiovascular risk in postmenopause. Thieme Publicações Ltda Rio de Janeiro, Brazil.

  3. Efficacy and tolerability of high dose "ethinylestradiol" in post-menopausal advanced breast cancer patients heavily pre-treated with endocrine agents.

    Science.gov (United States)

    Agrawal, Amit; Robertson, John F R; Cheung, K L

    2006-07-11

    High dose estrogens (HDEs) were frequently used as endocrine agents prior to the introduction of tamoxifen which carries fewer side effects. Due to the development of resistance to available endocrine agents in almost all women with metastatic breast cancer, interest has renewed in the use of HDEs as yet another endocrine option that may have activity. We report our experience with one of the HDEs ("ethinylestradiol" 1 mg daily) in advanced breast cancer (locally advanced and metastatic) in post-menopausal women who had progressed on multiple endocrine agents. According to a database of advanced breast cancer patients seen in our Unit since 1998, those who had complete set of information and fulfilled the following criteria were studied: (1) patients in whom further endocrine therapy was deemed appropriate i.e., patients who have had clinical benefit with previous endocrine agents or were not fit or unwilling to receive chemotherapy in the presence of potentially life-threatening visceral metastases; (2) disease was assessable by UICC criteria; (3) were treated with "ethinylestradiol" until they were withdrawn from treatment due to adverse events or disease progression. Twelve patients with a median age of 75.1 years (49.1-85 years) were identified. Majority (N = 8) had bony disease. They had ethinylestradiol as 3rd to 7th line endocrine therapy. One patient (8%) came off treatment early due to hepato-renal syndrome. Clinical benefit (objective response or durable stable disease for > or = 6 months) was seen in 4 patients (33.3%) with a median duration of response of 10+ (7-36) months. The time to treatment failure was 4 (0.5-36) months. Yet unreported, high dose "ethinylestradiol" is another viable therapeutic strategy in heavily pre-treated patients when further endocrine therapy is deemed appropriate. Although it tends to carry more side effects, they may not be comparable to those of other HDEs (such as diethylstilbestrol) or chemotherapy.

  4. Effect of yoga therapy on reaction time, biochemical parameters and wellness score of peri and post-menopausal diabetic patients

    Directory of Open Access Journals (Sweden)

    Madanmohan

    2012-01-01

    Discussion : Shortening of RT implies an improvement in the information processing and reflexes and is the first such report in diabetic patients. This has clinical significance and is worth further exploration with wider, well controlled, randomized studies in the diabetic population. Changes in blood glucose levels may be due to improved insulin sensitivity, decline in insulin resistance and increased sensitivity of the pancreatic b cells to glucose signals. Yoga improved the ′heart friendly′ status of lipid profile in our subjects and as our participants were peri and post-menopausal, the decrease in cardiovascular risk profile is of greater significance. A comprehensive yoga therapy program has the potential to enhance the beneficial effects of standard medical management of diabetes mellitus and can be used as an effective complementary or integrative therapy program.

  5. Cardiorenal disease connection during post-menopause: The protective role of estrogen in uremic toxins induced microvascular dysfunction.

    Science.gov (United States)

    Pei, Jiayi; Harakalova, Magdalena; den Ruijter, Hester; Pasterkamp, Gerard; Duncker, Dirk J; Verhaar, Marianne C; Asselbergs, Folkert W; Cheng, Caroline

    2017-07-01

    Female gender, post-menopause, chronic kidney disease (CKD) and (CKD linked) microvascular disease are important risk factors for developing heart failure with preserved ejection fraction (HFpEF). Enhancing our understanding of the interrelation between these risk factors could greatly benefit the identification of new drug targets for future therapy. This review discusses the evidence for the protective role of estradiol (E 2 ) in CKD-associated microvascular disease and related HFpEF. Elevated circulating levels of uremic toxins (UTs) during CKD may act in synergy with hormonal changes during post-menopause and could lead to coronary microvascular endothelial dysfunction in HFpEF. To elucidate the molecular mechanism involved, published transcriptome datasets of indoxyl sulfate (IS), high inorganic phosphate (HP) or E 2 treated human derived endothelial cells from the NCBI Gene Expression Omnibus database were analyzed. In total, 36 genes overlapped in both IS- and HP-activated gene sets, 188 genes were increased by UTs (HP and/or IS) and decreased by E 2 , and 572 genes were decreased by UTs and increased by E 2 . Based on a comprehensive in silico analysis and literature studies of collected gene sets, we conclude that CKD-accumulated UTs could negatively impact renal and cardiac endothelial homeostasis by triggering extensive inflammatory responses and initiating dysregulation of angiogenesis. E 2 may protect (myo)endothelium by inhibiting UTs-induced inflammation and ameliorating UTs-related uremic bleeding and thrombotic diathesis via restored coagulation capacity and hemostasis in injured vessels. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

  6. Belgian Firms Visit CERN

    CERN Multimedia

    2001-01-01

    Fifteen Belgian firms visited CERN last 2 and 3 April to present their know-how. Industrial sectors ranging from precision machining to electrical engineering and electronics were represented. And for the first time, companies from the Flemish and Brussels regions of the country joined their Walloon compatriots, who have come to CERN before. The visit was organised by Mr J.-M. Warêgne, economic and commercial attaché at the Belgian permanent mission for the French-speaking region, Mr J. Van de Vondel, his opposite number for the Flemish region, and Mrs E. Solowianiuk, economic and commercial counsellor at the Belgian permanent mission for the Brussels-Capital region.

  7. Belgian national report

    International Nuclear Information System (INIS)

    Berthe, J.

    1998-01-01

    Status of Belgian nuclear power plants includes licensing, in-service inspection programs, state of electrical equipment and predictive maintenance. In terms of life management of NPPs degradation phenomena affect the design life of each component. Combination of in-service inspection, periodic testing, specific measurements, qualification test and overall experience supports maintenance programs and enable repairs and replacements in due time. These programs are part of continuous safety assessments performed. Managing NPP life encompasses technical aspects for safe and reliable operation and economical aspects. The approach of Belgian authorities resulted in high availability, competitive cost and reasonable long-term perspectives

  8. Efficacy and tolerability of high dose "ethinylestradiol" in post-menopausal advanced breast cancer patients heavily pre-treated with endocrine agents

    Directory of Open Access Journals (Sweden)

    Robertson John FR

    2006-07-01

    Full Text Available Abstract Background High dose estrogens (HDEs were frequently used as endocrine agents prior to the introduction of tamoxifen which carries fewer side effects. Due to the development of resistance to available endocrine agents in almost all women with metastatic breast cancer, interest has renewed in the use of HDEs as yet another endocrine option that may have activity. We report our experience with one of the HDEs ("ethinylestradiol" 1 mg daily in advanced breast cancer (locally advanced and metastatic in post-menopausal women who had progressed on multiple endocrine agents. Patients and methods According to a database of advanced breast cancer patients seen in our Unit since 1998, those who had complete set of information and fulfilled the following criteria were studied: (1 patients in whom further endocrine therapy was deemed appropriate i.e., patients who have had clinical benefit with previous endocrine agents or were not fit or unwilling to receive chemotherapy in the presence of potentially life-threatening visceral metastases; (2 disease was assessable by UICC criteria; (3 were treated with "ethinylestradiol" until they were withdrawn from treatment due to adverse events or disease progression. Results Twelve patients with a median age of 75.1 years (49.1 – 85 years were identified. Majority (N = 8 had bony disease. They had ethinylestradiol as 3rd to 7th line endocrine therapy. One patient (8% came off treatment early due to hepato-renal syndrome. Clinical benefit (objective response or durable stable disease for ≥ 6 months was seen in 4 patients (33.3% with a median duration of response of 10+ (7–36 months. The time to treatment failure was 4 (0.5–36 months. Conclusion Yet unreported, high dose "ethinylestradiol" is another viable therapeutic strategy in heavily pre-treated patients when further endocrine therapy is deemed appropriate. Although it tends to carry more side effects, they may not be comparable to those of other

  9. Body image disturbance and surgical decision making in egyptian post menopausal breast cancer patients.

    Science.gov (United States)

    Shoma, Ashraf M; Mohamed, Madiha H; Nouman, Nashaat; Amin, Mahmoud; Ibrahim, Ibtihal M; Tobar, Salwa S; Gaffar, Hanan E; Aboelez, Warda F; Ali, Salwa E; William, Soheir G

    2009-08-13

    In most developing countries, as in Egypt; postmenopausal breast cancer cases are offered a radical form of surgery relying on their unawareness of the subsequent body image disturbance. This study aimed at evaluating the effect of breast cancer surgical choice; Breast Conservative Therapy (BCT) versus Modified Radical Mastectomy (MRM); on body image perception among Egyptian postmenopausal cases. One hundred postmenopausal women with breast cancer were divided into 2 groups, one group underwent BCT and the other underwent MRM. Pre- and post-operative assessments of body image distress were done using four scales; Breast Impact of Treatment Scale (BITS), Impact of Event Scale (IES), Situational Discomfort Scale (SDS), and Body Satisfaction Scale (BSS). Preoperative assessment showed no statistical significant difference regarding cognitive, affective, behavioral and evaluative components of body image between both studied groups. While in postoperative assessment, women in MRM group showed higher levels of body image distress among cognitive, affective and behavioral aspects. Body image is an important factor for postmenopausal women with breast cancer in developing countries where that concept is widely ignored. We should not deprive those cases from their right of less mutilating option of treatment as BCT.

  10. Low-Dose Intravaginal Estriol and Pelvic Floor Rehabilitation in Post-Menopausal Stress Urinary Incontinence.

    Science.gov (United States)

    Castellani, Daniele; Saldutto, Pietro; Galica, Vikiela; Pace, Gianna; Biferi, Daniela; Paradiso Galatioto, Giuseppe; Vicentini, Carlo

    2015-01-01

    Pelvic floor muscle training (PFMT) and electrical stimulation (ES) are conservative models of therapy for treating female stress urinary incontinence (SUI). The presence of estradiol receptors in the lower urinary tract advances the case for estradiol therapy in SUI. The aim of our study was to investigate the effects of the combination of pelvic floor rehabilitation and intravaginal estriol (IE) on SUI treatment in postmenopausal women. Sixty-two women with SUI were randomized to PFMT, ES and biofeedback (Group 1) or the same treatment plus 1 mg IE (Group 2) for 6 months. Patients were evaluated with medical history, pelvic examination, urodynamics, 24-hour pad test. Urinary incontinence was evaluated using the International Consultation on Incontinence questionnaire on urinary incontinence short form and quality of life using the Incontinence Impact Questionnaire-Short Form. Two patients were lost at follow-up and one discontinued the study. Mean urine leakage at the 24-hour pad test dropped from 42.3 ± 20.2 g/die to 31.5 ± 14.2 g/die in Group 1 and from 48.3 ± 19.8 g/die to 22.3 ± 10.1 g/die in Group 2. Symptoms scores and incontinence status were statistically significant better in Group 2 when compared to Group 1. IE added to PFMT, ES and BF is a safe and efficacious first-line therapy in postmenopausal women with SUI. © 2015 S. Karger AG, Basel.

  11. Upper gastrointestinal bleed in a post menopausal woman due to combination of high first dose aspirin and clopidogrel prescribed for acute coronary syndrome

    Directory of Open Access Journals (Sweden)

    Vishal R Tandon

    2015-01-01

    Full Text Available Combination of aspirin, clopidogrel and enoxaparin remains the standard treatment for acute coronary syndrome (ACS but is known to increase the incidence of upper gastrointestinal bleed (UGIB. We hereby report an unusual case of gastrointestinal bleed (GIB as it resulted inspite of proton pump inhibitor (PPI prophylaxis within the second day of treatment in a post-menopausal woman (PMW with high first dose of aspirin clopidogrel dual combination in a patient of ACS.

  12. Serum follicle-stimulating hormone level is associated with human epidermal growth factor receptor type 2 and Ki67 expression in post-menopausal females with breast cancer.

    Science.gov (United States)

    Zhou, Jun; Chen, Yiding; Huang, Yiting; Long, Jinpei; Wan, Fang; Zhang, Suzhan

    2013-10-01

    The present study aimed to determine the association between levels of the gender hormones, follicle-stimulating hormone (FSH), luteinizing hormone (LH), progesterone (P) and prolactin (PRL), and two breast cancer molecular markers, human epidermal growth factor receptor 2 (Her-2) and Ki67, in post-menopausal patients with breast cancer. A retrospective study of the serum hormone levels of FSH, LH, P and PRL and the expression status of Her-2 and Ki67 was performed using 187 post-menopausal females with breast cancer. Her-2 + breast cancer patients exhibited higher serum FSH levels compared with Her-2 - patients (69.47±3.219 vs. 58.56±1.516 IU/l). The patients with high Ki67 expression [immunohistochemistry (IHC), 3+] displayed higher FSH (72.51±4.616 vs. 60.53±1.476 IU/l) and LH (32.33±1.916 vs. 26.98±0.8852 IU/l) levels than those with lower Ki67 expression. No correlation was identified between the FSH, LH, P and PRL hormone levels, tumor stages and lymphovascular invasion (LVI). In conclusion, a higher serum FSH level was identified in Her-2 + post-menopausal patients with breast cancer. Higher serum FSH and LH levels were also observed in breast cancer patients with high Ki67 expression. FSH and LH may function in the progression of breast cancer.

  13. Treatment patterns and real world clinical outcomes in ER+/HER2- post-menopausal metastatic breast cancer patients in the United States.

    Science.gov (United States)

    Zanotti, Giovanni; Hunger, Matthias; Perkins, Julia J; Horblyuk, Ruslan; Martin, Monique

    2017-06-02

    With several new therapies becoming available, treatment of metastatic breast cancer (mBC) is evolving. The objective of this study is to describe patient characteristics, treatment patterns and real-world clinical outcomes in post-menopausal women with ER+, HER2- mBC and to obtain insight into patient outcomes and potential unmet needs with current therapies. The current study is a physician survey followed by a retrospective chart review of patient medical records by physicians in the US between March and April 2015. One hundred three physicians were asked to complete an online survey aiming to understand their satisfaction and expectations with current available treatments and potential areas of unmet need for mBC patients. Medical records from 178 females were extracted for the chart review. Using these data from medical records, patient characteristics and treatment patterns were analyzed descriptively. Time to progression (TTP) on first line, and progression-free survival (PFS) on second and third line of therapy were analyzed using the Kaplan-Meier method. Sixty-seven percent (n = 119) of patients had metastatic disease at initial diagnosis of breast cancer. Mean age at chart data extraction was 65.8 (SD: 9.4) years. Aromatase inhibitors (AIs) were prescribed for 58% and around 13% of patients in first line and second line, respectively. Chemotherapy was prescribed to 14% in first line and 31% in second line. Median TTP on first line therapy was 12 months for patients receiving AIs as compared to 7.9 months for patients receiving chemotherapy. Across all treatment lines, bone pain and fatigue were reported as the main symptoms associated with disease progression which had an impact on patient quality of life. Physicians expressed that prolonging life was deemed the most important treatment goal, followed by preservation or improvement of quality of life. In this study the majority of patients received endocrine therapy as first line treatment and current

  14. Symptomatic ovarian steroid cell tumor not otherwise specified in a post-menopausal woman

    Directory of Open Access Journals (Sweden)

    Neha Sood

    2016-06-01

    Full Text Available Steroid cell tumor not otherwise specified (NOS is a rare subtype of sex cord stromal tumor of the ovary and contributes less than 0.1% of all ovarian neoplasms. The majority of tumors occur in pre-menopausal women (mean age: 43 years, in which 56-77% of patients present with virilization due to excess testosterone. An 80-year-old woman with worsening alopecia and excessive growth of coarse hair on abdomen and genital area was found to have elevated serum testosterone level (462 ng/mL. Radiologic studies were consistent with bilateral adrenal adenomas. Bilateral adrenal venous sampling ruled out the adrenal gland as origin of hormone secretion. A diagnostic and therapeutic bilateral salpingooophorectomy confirmed steroid cell tumor NOS of the left ovary. Post-operatively, the patient had complete resolution of her symptoms and normalization of testosterone level. Our case emphasizes the importance of a clinical suspicion for an occult testosterone secreting ovarian tumor in a symptomatic patient without obvious ovarian mass on imaging.

  15. Osteocalcin carboxylation is not associated with body weight or percent fat changes during weight loss in post menopausal women

    Science.gov (United States)

    Osteocalcin (OC) is a vitamin K-dependent bone protein used as a marker of bone formation. Mouse models have demonstrated a role for the uncarboxylated form of OC (ucOC) in energy metabolism, including energy expenditure and adiposity, but human data are equivocal. To determine the associations betw...

  16. Optical Transillumination Spectroscopy of Breast Tissue to Determine the Cancer Risk in Pre and Post-Menopausal Women

    National Research Council Canada - National Science Library

    Lilge, Lothar

    2003-01-01

    Cancer risk assessment is becoming an important tool in determining an individual's screening and surveillance needs in order to maximize the probability of early cancer detection, or to initiate interventions...

  17. Effect of long-term estrogen therapy on dopaminergic responsivity in post-menopausal women--a preliminary study

    NARCIS (Netherlands)

    Craig, M. C.; Cutter, W. J.; Wickham, H.; van Amelsvoort, T. A. M. J.; Rymer, J.; Whitehead, M.; Murphy, D. G. M.

    2004-01-01

    Females have a higher prevalence than men of neuropsychiatric disorders in which dopaminergic abnormalities play a prominent role, e.g. very late-onset schizophrenia and Parkinson's disease (PD). The biological basis of these sex differences is unknown but may include modulation of the dopaminergic

  18. Study on reproductive endocrinological function in postmenopausal women treated with estriol

    International Nuclear Information System (INIS)

    Li Wenqi; Zhou Zhenli; Zhou Jiwen; Li Xin

    2002-01-01

    Objective: To investigate the reproductive endocrinological function in postmenopausal women treated with ultralente estriol for 3 years. Methods: Serum levels of six reproductive hormones (FSH, LH, PRL, T, E 2 , P) were measured with RIA in 1) 136 normal 1-5yrs post-menopausal women 2) 48 post-menopausal women treated with estriol for 3 years 3) 131 healthy women of child-bearing age during follicular and luteal phases. Results: Serum levels of the six reproductive hormones in women of child-bearing age at both follicular and luteal phases were significantly different from those in post-menopausal women (p 2 , P and T levels were not significant (p > 0.05). Conclusion: Serum reproductive hormones assay is important for monitoring hormone replacement therapy in aging women

  19. Two Belgian University Hospitals

    Directory of Open Access Journals (Sweden)

    M. Huylebrouck

    2012-01-01

    Full Text Available Background. Bevacizumab (BEV, a humanized immunoglobulin G1 monoclonal antibody that inhibits VEGF has demonstrated activity against recurrent high-grade gliomas (HGG in phase II clinical trials. Patients and Methods. Data were collected from patients with recurrent HGG who initiated treatment with BEV outside a clinical trial protocol at two Belgian university hospitals. Results. 19 patients (11 M/8 F were administered a total of 138 cycles of BEV (median 4, range 1–31. Tumor response assessment by MRI was available for 15 patients; 2 complete responses and 3 partial responses for an objective response rate of 26% for the intent to treat population were observed on gadolinium-enhanced T1-weighted images; significant regressions on T2/FLAIR were documented in 10 out of 15 patients (67%. A reduced uptake on PET was documented in 3 out of 4 evaluable patients. The six-month progression-free survival was 21% (95% CI 2.7–39.5. Two patients had an ongoing tumor response and remained free from progression after 12 months of BEV treatment. Conclusions. The activity and tolerability of BEV were comparable to results from previous prospective phase II trials. Reduced uptake on PET suggests a metabolic response in addition to an antiangiogenic effect in some cases with favorable clinical outcome.

  20. Postmenopausal Experiences in Nigerian Women | Adegoke ...

    African Journals Online (AJOL)

    A questionnaire study of 358 randomly selected post menopausal women in the Lagos metropolis was undertaken. Their menopausal symptoms and manner of coping with adverse side effects were enquired about. Questions were also asked about the ages respondents started and stopped menstruation as well as their ...

  1. Open Access to the Belgian Nuclear higher Education Network

    International Nuclear Information System (INIS)

    Simons, S.

    2005-01-01

    Under the name of the Belgian Nuclear higher Education Network, five Belgian universities, Universite Catholique de Louvain, Universiteit Gent, Universite de Liege, Vrije Universiteit Brussel have established in 2002, in collaboration with the Belgian Nuclear Research Centre SCK-CEN, a common Belgian Interuniversity Programme of the third cycle leading to the academic degree of Master of Science in Nuclear Engineering. Under the lead of the SCK-CEN a project to use and share the acquired experience of the Consortium BNEN - in order to support the realization of a common European Education Programme in Nuclear Engineering - has been accepted by the European Commission for funding under the EU's Sixth Research Framework Programme.The project wants to contribute actively to the development of a more harmonised approach for education in nuclear sciences and engineering in Europe. It brings the European higher Education Area closer to realization and helps to safeguard the necessary competence and expertise for the continued safe use of nuclear energy and other uses of radiation in industry and medicine in Europe. The project foresees input and participation from stakeholders from different countries of the enlarged European Union (EU-25) and will therefore contribute to the integration of the new member states into the European Research Area and thus to the enlargement of Europe. The set-up of the project foresees an active role for female experts with the intention to reinforce the place and role of women in science

  2. Clinicopathological Spectrum of Endometrial Changes in Peri-menopausal and Post-menopausal Abnormal Uterine Bleeding: A 2 Years Study

    OpenAIRE

    Damle, Rajshri P.; Dravid, N.V.; Suryawanshi, Kishor H.; Gadre, Arundhati S.; Bagale, Priya S.; Ahire, Neelam

    2013-01-01

    Background: Abnormal uterine bleeding is the Common presenting complaint in Gynaecology Outpatient Department in all age groups. It is due to the anovulatory cycles which are commonly seen in adolescent and peri-menopausal women. Abnormal uterine bleeding is caused by wide variety of organic or non-organic causes. Histopathological examination of endometrial sample remains the gold standard for diagnosis of endometrial pathology.

  3. Study on the therapeutic effect of small dose of estradiol and progesterone on post-menopausal osteoporosis

    International Nuclear Information System (INIS)

    Li Wenqi; Li Xin; Zhou Jiwen; Zhou Zhengli

    2004-01-01

    Objective: To explore the therapeutic effect and possible adverse side-effects of small dose of estradiol and progesterone on postmenopausal osteoporosis. Methods: Applying a GBD-928 mono-photon BMD radiometer, 68 women (past-menopausal over 3 years, age 52-59, body weight index 2 0.5 mg with MPA (medroxyprogesterone acetate) 0.5 mg daily. The medication laster for a whole years and BMD value was measured again. All subjects underwent gynecological physical examination, vaginal sonography, vaginal smear study and breast examination with infra-red ray both before and after the test period. Results: After one year medication, mean value of BMD in Group A was 0.49 ± 0.05, three percentage points higher than before. In Group B, this was 0.52 ± 0.06, another three percentage points higher. Ten Women with mild lobular hyperplasia and nine women with small uterine myoma ( 3 ) were all allocated to the hormone treated group. The lesions showed either little change or slight regression after the test period. Conclusion: Osteoporotic women receiving additional small doses of female hormones responded much better than those receiving calcium only. The WHI report which advised against HRT should be more critically studied

  4. Legal claims against Belgian reactors?

    International Nuclear Information System (INIS)

    Raetzke, Christian

    2016-01-01

    The Belgian reactors Tihange 2 and Doel 3 have been restarted in November 2015 after the problem of hydrogen flakes in the reactor pressure vessels had been investigated. The permission to restart has been the object both of critical statements by the German Federal Ministry of the Environment (BMUB) and of lawsuits filed with Belgian law courts by a group of German municipalities led by the city of Aachen and by the Land North-Rhine-Westphalia. According to a general principle of the law of nations, a state is not permitted to operate installations near its border, which cause significant environmental damage in a neighbouring state. However, it is not quite clear how this principle applies to the issue of potential accidents of nuclear power plants. According to the author, a tangible threat of an accident is required; mere doubts and concerns about the extent of safety margins are not sufficient.

  5. Radioimmunological methods of hormone profile investigation in postmenopause women

    International Nuclear Information System (INIS)

    Chernova, N.V.; Shatins'ka-Mitsik, Yi.S.; Mitsik, Yu.O.

    2009-01-01

    The investigation of the peculiarities of hypophyseothyroid system and pathogenetic role of hyperandrogeny in coronary artery disease in women with abdominal obesity in post-menopause allowed to establish a positive correlation of low density lipoproteids with thyrotropic hormone level and negative with free thyroxin.

  6. Prevalence of osteoporosis increased in postmenopausal women with postural scoliosis

    Directory of Open Access Journals (Sweden)

    Maria Regina Rachmawati

    2015-12-01

    In post menopausal women with postural scoliosis found a higher incidence of osteoporosis. High endurance of erector spinae muscle lowers the risk of scoliosis. Exercise to improve posture and increase endurance of erector spinae muscle need to be done to prevent decline of BMD.

  7. Scintigraphic examinations during pregnancy and in breast-feeding women: a survey of Belgian nuclear medicine physician's attitudes; Examens scintigraphiques durant la grossesse et chez les femmes en periode d'allaitement: enquete a propos des attitudes pratiques des nuclearistes belges

    Energy Technology Data Exchange (ETDEWEB)

    Tondeur, M.; Ham, H. [Centre Hospitalier Universitaire Saint Pierre, Bruxellex (Belgium); Sand, A. [CEDRI, Vilvoorde (Belgium)

    2003-05-01

    Radiation protection is of major importance in pregnant and breast feeding women. This work was undertaken to assess the practices of Belgian nuclear medicine physicians towards performing diagnostic tests during pregnancy and in breast feeding women. A questionnaire was sent to 201 Belgian nuclear medicine physicians; 82 answers (41 %) were received. 51 % of the responding physicians agree to perform lung perfusion scan during pregnancy provided a reduced dose is administered, 33% refuse to perform it during first three months and 24% refuse to perform it for pregnancies older than three months. For the Tc-99m ventilation scan 79% and 66% refuse to perform it before and after first three months. Better agreement was observed for other Tc-99m scintigraphies or tests using other radionuclides. In breast feeding women 89% agree to perform Tc-99m tests provided a breast feeding break; however, the duration of this break appears variable. The need for obtaining a written informed consent appears controversial. Given the variability of the attitudes of nuclear medicine physicians, official guidelines for nuclear medicine diagnostic tests during pregnancy is needed. (authors)

  8. Benefits of Walking on Menopausal Symptoms and Mental Health Outcomes among Chinese Postmenopausal Women

    Directory of Open Access Journals (Sweden)

    Liang Hu

    2017-09-01

    Conclusion: Walking could be recommended for post-menopausal women to manage menopausal symptoms and promote psychological well-being. Life satisfaction may be enhanced through the improvement of mental and physical parameters (e.g., menopausal symptoms, BMI and depression.

  9. The Belgian nuclear research centre

    International Nuclear Information System (INIS)

    Moons, F.

    2001-01-01

    The Belgian Nuclear Research Centre is almost exclusively devoted to nuclear R and D and services and is able to generate 50% of its resources (out of 75 million Euro) by contract work and services. The main areas of research include nuclear reactor safety, radioactive waste management, radiation protection and safeguards. The high flux reactor BR2 is extensively used to test fuel and structural materials. PWR-plant BR3 is devoted to the scientific analysis of decommissioning problems. The Centre has a strong programme on the applications of radioisotopes and radiation in medicine and industry. The centre has plans to develop an accelerator driven spallation neutron source for various applications. It has initiated programmes to disseminate correct information on issues of nuclear energy production and non-energy nuclear applications to different target groups. It has strong linkages with the IAEA, OECD-NEA and the Euratom. (author)

  10. Detection of carotid artery calcification on the panoramic images of post-menopausal females is significantly associated with severe abdominal aortic calcification: a risk indicator of future adverse vascular events.

    Science.gov (United States)

    Friedlander, A H; El Saden, S M; Hazboun, R C; Chang, T I; Wong, W K; Garrett, N R

    2015-01-01

    Outcome studies among post-menopausal females with calcified carotid artery plaque (CCAP) on their panoramic images have not been previously undertaken. We sought to compare the extent of abdominal aortic calcification (AAC) on lateral lumbar spine radiographs (LLSRs), among groups of females with (CCAP+) and without (CCAP-) carotid lesions on their panoramic images. "Severe" levels of AAC have previously been validated as a risk indicator of future adverse cardiovascular events. This cross-sectional case-control study included a "CCAP+ group" consisting of females more than 50 years of age having the carotid lesion diagnosed by their dentists and an atherogenic risk factor (age, body mass index, hypertension, diabetes and dyslipidaemia)-matched "CCAP- group". A physician radiologist, using the Framingham index, evaluated the LLSRs for the magnitude of AAC. Summary statistics for key variables were computed and conditional logistic regression techniques were considered. Members of the CCAP+ group were significantly (p=0.038) more likely to demonstrate "severe" levels of AAC on their LLSRs than members of the CCAP group. This is the first published study demonstrating that CCAP on panoramic images of post-menopausal females is significantly associated with "severe" levels of AACs on LLSRs independent of traditional risk factors. Given that these levels of AAC are a validated risk indicator of future myocardial infarction and stroke, dentists must evaluate the panoramic images of post-menopausal females for the presence of CCAP. Patients with carotid atheromas should be referred to their physicians for further evaluation given the systemic implications.

  11. Belgian Federalism after the Sixth State Reform

    Directory of Open Access Journals (Sweden)

    Goossens Jurgen

    2015-11-01

    Full Text Available This paper highlights the most important institutional evolutions of Belgian federalism stemming from the implementation of the sixth state reform (2012-2014. This reform inter alia included a transfer of powers worth 20 billion euros from the federal level to the level of the federated states, a profound reform of the Senate, and a substantial increase in fiscal autonomy for the regions. This contribution critically analyses the current state of Belgian federalism. Although the sixth state reform realized important and long-awaited changes, further evolutions are to be expected. Since the Belgian state model has reached its limits with regard to complexity and creativity, politicians and academics should begin to reflect on the seventh state reform with the aim of increasing the transparency of the current Belgian institutional labyrinth.

  12. Obstructive sleep apnea in postmenopausal women: a comparative study using drug induced sleep endoscopy.

    Science.gov (United States)

    Koo, Soo Kweon; Ahn, Gun Young; Choi, Jang Won; Kim, Young Jun; Jung, Sung Hoon; Moon, Ji Seung; Lee, Young Il

    The key to successful treatment of OSAS is to individually tailor such treatment. Thus, it is very important to determine the severity of OSAS, its pattern, and the extent of collapse, by gender, age, and BMI. The objective of the study was to understand the characteristics of obstructive sleep apnea in postmenopausal women by comparing postmenopausal and premenopausal subjects, and men, using DISE. We hope that our work will help the medical community to consult on, diagnose, and treat OSAS more effectively. A total of 273 patients (195 males and 78 females) diagnosed with OSAS were enrolled. Female patients were divided into pre-menopausal (n=41) and post-menopausal patients (n=37). The group of post-menopausal female patients was matched with a group of male patients with similar age and body mass index (BMI). DISE findings were compared between pre-menopausal female patients and post-menopausal female patients, and also between post-menopausal female patients and male patients matched for age and BMI. Upon PSG examination, post-menopausal patients (who had a significantly higher BMI than did pre-menopausal patients; 25.6kg/m 2 vs. 23.5kg/m 2 ; p=0.019) tended to have a higher AHI and a lower lowest SaO 2 , but the differences did not attain statistical significance. With DISE analysis, post-menopausal female patients showed higher values in all obstruction sites, with significantly higher value in lateral diameter of retropalatal (1.49 vs. 0.90; p=0.001) and retrolingual levels (1.14 vs. 0.61; p=0.003) compared to pre-menopausal females patients. Post-menopausal female patients showed significantly more retrolingual collapse (antero-posterior, AP, p≤0.0001, and lateral diameter, p=0.042) in the lower BMI group (BMI<25) and more concentric retropalatal collapse (lateral diameter, p=0.017 and tonsillar obstruction, p=0.003) in higher BMI group (BMI≥25) than BMI and age matched male patients. Post-menopausal female patients showed a different pattern of airway

  13. Obstructive sleep apnea in postmenopausal women: a comparative study using drug induced sleep endoscopy

    Directory of Open Access Journals (Sweden)

    Soo Kweon Koo

    Full Text Available Abstract Introduction: The key to successful treatment of OSAS is to individually tailor such treatment. Thus, it is very important to determine the severity of OSAS, its pattern, and the extent of collapse, by gender, age, and BMI. Objective: The objective of the study was to understand the characteristics of obstructive sleep apnea in postmenopausal women by comparing postmenopausal and premenopausal subjects, and men, using DISE. We hope that our work will help the medical community to consult on, diagnose, and treat OSAS more effectively. Methods: A total of 273 patients (195 males and 78 females diagnosed with OSAS were enrolled. Female patients were divided into pre-menopausal (n = 41 and post-menopausal patients (n = 37. The group of post-menopausal female patients was matched with a group of male patients with similar age and body mass index (BMI. DISE findings were compared between pre-menopausal female patients and post-menopausal female patients, and also between post-menopausal female patients and male patients matched for age and BMI. Results: Upon PSG examination, post-menopausal patients (who had a significantly higher BMI than did pre-menopausal patients; 25.6 kg/m2 vs. 23.5 kg/m2; p = 0.019 tended to have a higher AHI and a lower lowest SaO2, but the differences did not attain statistical significance. With DISE analysis, post-menopausal female patients showed higher values in all obstruction sites, with significantly higher value in lateral diameter of retropalatal (1.49 vs. 0.90; p = 0.001 and retrolingual levels (1.14 vs. 0.61; p = 0.003 compared to pre-menopausal females patients. Post-menopausal female patients showed significantly more retrolingual collapse (antero-posterior, AP, p ≤ 0.0001, and lateral diameter, p = 0.042 in the lower BMI group (BMI < 25 and more concentric retropalatal collapse (lateral diameter, p = 0.017 and tonsillar obstruction, p = 0.003 in higher BMI group (BMI ≥ 25 than BMI and age matched

  14. Effect of 17β-estradiol on plasma lipids and LDL oxidation in postmenopausal women with type II diabetes mellitus

    NARCIS (Netherlands)

    Brussaard, H.E.; Leuven, J.A.G.; Kluft, C.; Krans, H.M.J.; Duyvenvoorde, W. van; Buytenhek, R.; Laarse, A. van der; Princen, H.M.G.

    1997-01-01

    In type II diabetes mellitus the altered hormonal state after menopause may represent an additional cardiovascular risk factor. Estrogen replacement therapy (ERT) is associated with a decreased cardiovascular risk, at least in nondiabetic post-menopausal women. We studied the effect of ERT on plasma

  15. The impact of gendered friendship patterns on the prevalence of homophobia among belgian late adolescents.

    Science.gov (United States)

    Hooghe, Marc

    2011-06-01

    In order to assess the determinants of homophobia among Belgian adolescents, a shortened version of the Homophobia scale (Wright et al., 1999) was included in a representative survey among Belgian adolescents (n = 4,870). Principal component analysis demonstrated that the scale was one-dimensional and internally coherent. The results showed that homophobia is still widespread among Belgian adolescents, despite various legal reforms in the country aiming to combat discrimination of gay women and men. A multivariate regression analysis demonstrated that boys, ethnic minorities, individuals with high levels of ethnocentrism and an instrumental worldview, Muslim minorities, and those with low levels of associational involvement scored significantly higher on the scale. While among boys an extensive friendship network was associated with higher levels of homophobia, the opposite phenomenon was found among girls. We discuss the possible relation between notions of masculinity within predominantly male adolescent friendship networks and social support for homophobia.

  16. Positive effects of a chicken eggshell powder-enriched vitamin-mineral supplement on femoral neck bone mineral density in healthy late post-menopausal Dutch women

    NARCIS (Netherlands)

    Schaafsma, A; van Doormaal, JJ; Muskiet, FAJ; Hofstede, GJH; Pakan, [No Value; van der Veer, E

    Although bone metabolism is largely under genetic control, the role of nutrition is considerable. The present study evaluates the effects of chicken eggshell powder, a new source of dietary Ca, and purified CaCO3 on bone mineral density (BMD) of the lumbar spine and hip. Besides BMD we also looked

  17. The effect of Korean pine nut oil on in vitro CCK release, on appetite sensations and on gut hormones in post-menopausal overweight women

    NARCIS (Netherlands)

    Pasman, W.J.; Heimerikx, J.; Rubingh, C.M.; Berg, R. van den; O'Shea, M.; Gambelli, L.; Hendriks, H.F.J.; Einerhand, A.W.C.; Scott, C.; Keizer, H.G.; Mennen, L.I.

    2008-01-01

    Appetite suppressants may be one strategy in the fight against obesity. This study evaluated whether Korean pine nut free fatty acids (FFA) and triglycerides (TG) work as an appetite suppressant. Korean pine nut FFA were evaluated in STC-1 cell culture for their ability to increase cholecystokinin

  18. Texture analysis of clinical radiographs using radon transform on a local scale for differentiation between post-menopausal women with and without hip fracture

    Science.gov (United States)

    Boehm, Holger F.; Körner, Markus; Baumert, Bernhard; Linsenmaier, Ulrich; Reiser, Maximilian

    2011-03-01

    Osteoporosis is a chronic condition characterized by demineralization and destruction of bone tissue. Fractures associated with the disease are becoming an increasingly relevant issue for public health institutions. Prediction of fracture risk is a major focus research and, over the years, has been approched by various methods. Still, bone mineral density (BMD) obtained by dual-energy X-ray absorptiometry (DXA) remains the clinical gold-standard for diagnosis and follow-up of osteoporosis. However, DXA is restricted to specialized diagnostic centers and there exists considerable overlap in BMD results between populations of individuals with and without fractures. Clinically far more available than DXA is conventional x-ray imaging depicting trabecular bone structure in great detail. In this paper, we demonstrate that bone structure depicted by clinical radiographs can be analysed quantitatively by parameters obtained from the Radon Transform (RT). RT is a global analysis-tool for detection of predefined, parameterized patterns, e.g. straight lines or struts, representing suitable approximations of trabecular bone texture. The proposed algorithm differentiates between patients with and without fractures of the hip by application of various texture-metrics based on the Radon-Transform to standard x-ray images of the proximal femur. We consider three different regions-of-interest in the proximal femur (femoral head, neck, and inter-trochanteric area), and conduct an analysis with respect to correct classification of the fracture status. Performance of the novel approach is compared to DXA. We draw the conclusion that performance of RT is comparable to DXA and may become a useful supplement to densitometry for the prediction of fracture risk.

  19. Plasma Metabolic Profiles in Women are Menopause Dependent.

    Directory of Open Access Journals (Sweden)

    Chaofu Ke

    Full Text Available Menopause is an endocrinological transition that greatly affects health and disease susceptibility in middle-aged and elderly women. To gain new insights into the metabolic process of menopause, plasma metabolic profiles in 115 pre- and post-menopausal women were systematically analyzed by ultra-performance liquid chromatography/mass spectrometry in conjunction with univariate and multivariate statistical analysis. Metabolic signatures revealed considerable differences between pre- and post-menopausal women, and clear separations were observed between the groups in partial least-squares discriminant analysis score plots. In total, 28 metabolites were identified as potential metabolite markers for menopause, including up-regulated acylcarnitines, fatty acids, lysophosphatidylcholines, lysophosphatidylethanolamines, and down-regulated pregnanediol-3-glucuronide, dehydroepiandrosterone sulfate, p-hydroxyphenylacetic acid and dihydrolipoic acid. These differences highlight that significant alterations occur in fatty acid β-oxidation, phospholipid metabolism, hormone metabolism and amino acid metabolism in post-menopausal women. In conclusion, our plasma metabolomics study provides novel understanding of the metabolic profiles related to menopause, and will be useful for investigating menopause-related diseases and assessing metabolomic confounding factors.

  20. Chocolate-candy consumption and three-year weight gain among postmenopausal U.S. women

    Science.gov (United States)

    Greenberg, James A.; Manson, JoAnn E.; Buijsse, Brian; Wang, Lu; Allison, Matthew A.; Neuhouser, Marian L.; Tinker, Lesley; Waring, Molly E.; Isasi, Carmen R.; Martin, Lisa W.; Thomson, Cynthia A.

    2014-01-01

    OBJECTIVE To test the hypothesis that greater chocolate-candy intake is associated with more weight gain in postmenopausal women. DESIGN AND METHODS Prospective cohort study involving 107,243 post-menopausal American women aged 50–79 years (mean=60.7) at enrolment in the Women’s Health Initiative (WHI), with three-year follow up. Chocolate-candy consumption was assessed by food frequency questionnaire and body weight was measured. Linear mixed models, adjusted for demographic, socio-economic, anthropomorphic and behavioral variables, were used to test our main hypotheses. RESULTS Compared to women who ate a 1 oz (~28 g) serving of chocolate candy chocolate-candy intake level increased as BMI increased above the normal range (18.5–25 kg/m2), and as age decreased. CONCLUSIONS Greater chocolate-candy intake was associated with greater prospective weight gain in this cohort of post-menopausal women. PMID:25644711

  1. The Belgian Nuclear Higher Education Network

    International Nuclear Information System (INIS)

    Moons, F.; D'Haeseleer, W.; Giot, M.

    2004-01-01

    Full text: BNEN, the Belgian Nuclear Higher Education Network has been created in 2001 by five Belgian universities and the Belgian Nuclear Research Centre (SCK-CEN) as a joint effort to maintain and further develop a high quality programme in nuclear engineering in Belgium. In a country where a substantial part of electricity generation will remain of nuclear origin for a number of years, there is a need for well educated and well trained engineers in this area. Public authorities, regulators and industry brought their support to this initiative. In the framework of the new architecture of higher education in Europe, the English name for this 60 ECTS programme is 'Master of Science in Nuclear Engineering'. To be admitted to this programme, students must already hold a university degree in engineering or equivalent. Linked with university research, benefiting from the human resources and infrastructure of SCK-CEN, encouraged and supported by the partners of the nuclear sector, this programme should be offered not only to Belgian students, but also more widely throughout Europe and the world. The master programme is a demanding programme where students with different high level backgrounds in engineering have to go through highly theoretical subjects like neutron physics, fluid flow and heat transfer modelling, and apply them to reactor design, nuclear safety and plant operation and control. At a more interdisciplinary level, the programme includes some important chapters of material science, with a particular interest for the fuel cycle. Radiation protection belongs also to the backbone of the programme. All the subjects are taught by academics appointed by the partner universities, whereas the practical exercises and laboratory sessions are supervised by researchers of SCK-CEN. The final thesis offers an opportunity for internship in industry or in a research laboratory. More information: http://www.sckcen.be/BNEN. (author)

  2. Relationship of homocysteine levels with lumbar spine and femur neck BMD in postmenopausal women

    OpenAIRE

    Elton Bahtiri; Hilmi Islami; Sylejman Rexhepi; Hasime Qorraj-Bytyqi; Kujtim Thaçi; Shpetim Thaçi; Çağla Karakulak; Rexhep Hoxha

    2015-01-01

    Objective: The focus of several studies in recent years has been the association between increased plasma concentrations of homocysteine (Hcy), reduced bone mineral density and increased risk of bone fractures. Nevertheless, inconsistencies persist in the literature. Thus, the objective of this study was to investigate the possible relationship between serum Hcy and vitamin B12 status, and bone mineral density, on a group of post-menopausal women. Materials and methods: One hundred thirty-nin...

  3. Efficacy and tolerability of high dose "ethinylestradiol" in post-menopausal advanced breast cancer patients heavily pre-treated with endocrine agents

    OpenAIRE

    Agrawal, Amit; Robertson, John FR; Cheung, KL

    2006-01-01

    Abstract Background High dose estrogens (HDEs) were frequently used as endocrine agents prior to the introduction of tamoxifen which carries fewer side effects. Due to the development of resistance to available endocrine agents in almost all women with metastatic breast cancer, interest has renewed in the use of HDEs as yet another endocrine option that may have activity. We report our experience with one of the HDEs ("ethinylestradiol" 1 mg daily) in advanced breast cancer (locally advanced ...

  4. Association between the polymorphisms of angiotensin converting enzyme (Peptidyl-Dipeptidase A INDEL mutation (I/D and Angiotensin II type I receptor (A1166C and breast cancer among post menopausal Egyptian females

    Directory of Open Access Journals (Sweden)

    Rania Mohamed El Sharkawy

    2014-09-01

    Results: A statistically significant difference in AT1R A1166C SNP genotype frequencies was found among the studied groups. The patients group showed higher frequency of “CC” (2.9% vs 0% and “AC” (44.3% vs 24% and lower frequency of “AA” genotype (52.9% vs 76% than controls. The patients also showed significant higher frequency of allele “C” (25% vs 12% which was associated with increased breast cancer risk with an Odds ratio of 2.4444 (95% CI: 1.1967–4.9931. Testing the dominant model of inheritance revealed a statistically higher frequency of exposed genotypes “AC and CC” among the patients group (47.1% vs 24%, respectively; p = 0.013 with substantial increase in breast cancer risk among the exposed genotypes with an Odds ratio of 2.8243 (95% CI: 1.2679–6.2913. The present study demonstrated that (AC and CC genotypes of AT1R A1166C SNP and increased BMI can be considered as predictors for breast cancer risk among post menopausal Egyptian females. Results also revealed that A1166C SNP of AT1R gene and ACE/ID polymorphism could not be considered as predictors for breast cancer prognosis.

  5. Fatores associados à qualidade de vida após menopausa Factors related to quality of life in post-menopause

    Directory of Open Access Journals (Sweden)

    Dino Roberto Soares De Lorenzi

    2006-10-01

    Full Text Available OBJETIVO: Avaliar a qualidade de vida de mulheres na pós-menopausa. MÉTODOS: Estudo transversal de 323 mulheres pós-menopáusicas com idade entre 45 e 60 anos atendidas em um serviço universitário de atenção ao climatério entre junho e outubro de 2002. A qualidade de vida foi avaliada através do Women's Health Questionnaire. Na análise estatística, utilizou-se o teste t de Student e a análise de variância, seguidos de regressão linear múltipla. RESULTADOS: A qualidade de vida se mostrou comprometida entre a população estudada, em especial nos domínios relacionados a sintomas somáticos, humor deprimido e ansiedade. Por meio de análise multivariada, constatou-se que quanto menor a escolaridade (pOBJECTIVE: To assess quality of life of postmenopausal women. METHODS: A cross-section study of 323 women between 45 and 60 years of age attended at a university climacteric clinic from June to October 2002was carried out. Quality of life was assessed by the Women's Health Questionnaire (WHQ. Statistical analysis was performed with Student's t Test and analysis of variance, followed by multiple linear regression analysis. RESULTS: This study found quality of life impaired especially in the domains related to somatic symptoms, depressed mood, and anxiety. Multivariate analysis showed that lower educational level (p<0.01, frequency of sexual activity (p<0.01 and the confirmation of previous clinical co-morbidities (p=0.03 were associated to the worst scores of quality of life. On the other hand, regular physical activity was related to better quality of life (p=0.01. Hormone therapy, in particular, was not related to quality of life (p=0.48. CONCLUSION: Quality of life was found not only to be influenced by biological factors, but also by psychossocial and cultural factors. Middle aged women frequently attributed eventual symptoms associated to clinical co-morbidities or previous emotional difficulties to menopause, distorting their

  6. Measurement of the natural radiation of the Belgian territory

    International Nuclear Information System (INIS)

    Gillard, J.; Flemal, J.M.; Deworm, J.P.; Slegers, W.

    1989-01-01

    A measurement campaign of natural occuring radionuclides was set up on the Belgian territory in order to assess the doses received by the Belgian population. The results of the measurements are published together with a map of natural occuring radionuclides and exposure rates. (L.D.C.)

  7. Atividade física habitual e risco cardiovascular na pós-menopausa Habitual physical activity and cardiovascular risk in post menopause

    Directory of Open Access Journals (Sweden)

    Raimunda Beserra da Silva

    2006-08-01

    Full Text Available OBJETIVO: Avaliar a prevalência de atividade física habitual e risco cardiovascular em mulheres na pós-menopausa. MÉTODOS: Estudo de coorte transversal com 162 mulheres, entre 40 e 65 anos, em amenorréia há no mínimo 12 meses, acompanhadas no Ambulatório de Menopausa do CAISM/UNICAMP. As mulheres responderam oralmente o questionário International Physical Activity Questionnaire para avaliação do nível de atividade física, que abordou a freqüência e duração das atividades ocorridas durante uma semana normal, realizadas no transporte, trabalho, em casa e no lazer, classificando-as em sedentárias, insuficientemente ativas, ativas e muito ativas. Foram realizados exames laboratoriais para dosagem sérica de colesterol total, lipoproteína de alta densidade, lipoproteína de baixa densidade, triglicérides, glicemia de jejum e medidas de pressão arterial sistólica e diastólica. RESULTADOS: A média de idade das mulheres foi de 56,5 anos e idade na menopausa de 46 anos. A prevalência de atividade física foi de 83,3%, sendo que 2,5% foram classificadas como muito ativas, 80,8% ativas e 16,7% insuficientemente ativas. A maioria realizava atividades, principalmente no transporte e em casa, e apenas 38,3% realizavam atividade física durante o lazer. Nesta população, 87,7% das mulheres apresentavam escore de Framingham inferior a 10, considerado de baixo risco cardiovascular. CONCLUSÃO: Mulheres na pós-menopausa apresentam alta prevalência de atividade física habitual e baixa aderência ao exercício físico. O risco cardiovascular foi baixo na população estudada. É importante incentivar e orientar esta população a praticar atividade física compatível com suas condições físicas, estimulando a prática não somente da atividade física habitual, mas também do exercício físico.BACKGROUND: To evaluate the prevalence of habitual physical activity and cardiovascular risk in postmenopausal women. METHODS: A cross

  8. Facial visualizations of women's voices suggest a cross-modality preference for femininity.

    Science.gov (United States)

    Röder, Susanne; Fink, Bernhard; Feinberg, David R; Neave, Nick

    2013-03-01

    Women with higher-pitched voices and more feminine facial features are commonly judged as being more attractive than are women with lower-pitched voices and less feminine faces, possibly because both features are affected by (age-related) variations in endocrine status. These results are primarily derived from investigations of perceptions of variations in single-modality stimuli (i.e., faces or voices) in samples of young adult women. In the present study we sought to test whether male and female perceptions of women's voices affect visual representations of facial femininity. Eighty men and women judged voice recordings of 10 young girls (11-15 years), 10 adult women (19-28 years) and 10 peri-/post-menopausal women (50-64 years) on age, attractiveness, and femininity. Another 80 men and women were asked to indicate the face they think each voice corresponded to using a video that gradually changed from a masculine looking male face into a feminine looking female face. Both male and female participants perceived voices of young girls and adult women to be significantly younger, more attractive and feminine than those of peri-/post-menopausal women. Hearing young girls' and adult women's voices resulted in both men and women selecting faces that differed markedly in apparent femininity from those associated with peri-/post-menopausal women's voices. Voices of young girls had the strongest effect on visualizations of facial femininity. Our results suggest a cross-modal preference for women's vocal and facial femininity, which depends on female age and is independent of the perceiver's sex.

  9. Performance of X-ray absorptiometry in post-menopausal vertebral osteoporosis. Discriminant value of vertebral and femoral measurements, fracture threshold, reproducibility

    International Nuclear Information System (INIS)

    Pouilles, J.M.; Tremollieres, F.; Ribot, C.

    1990-01-01

    The aim of this study was to assess the performance of a new bone densitometry technique, X-ray absorptiometry, in vertebral osteoporosis with fracture(s). Vertebral and femoral (neck, Ward's triangle and trochanter) bone density was measured in 60 women with at least one vertebral compression fracture of osteoporotic origin (mean age: 61), 100 controls of the same age and in 40 young adults (mean age: 30). Osteoporosis patients had significantly (p 2 , this value giving the best compromise between sensitivity (83%) and specificity (95%) with 91% of subjects appropriately classifed. Reproducibility was assessed in the short term in 9 osteoporosis patients. The mean standard deviation of measurements was 0.017 g/cm 2 (coefficient of variation: 2.6%) as compared with 0.010 g/cm 2 (coefficient of variation: 0.8%) in the young adult. These results emphasise the true advance represented by X-ray absorptiometry in the area of bone densitometry, notably in the assessment and monitoring of demineralisation disorders [fr

  10. Consumption of onion juice modulates oxidative stress and attenuates the risk of bone disorders in middle-aged and post-menopausal healthy subjects.

    Science.gov (United States)

    Law, Yat-Yin; Chiu, Hui-Fang; Lee, Hui-Hsin; Shen, You-Cheng; Venkatakrishnan, Kamesh; Wang, Chin-Kun

    2016-02-01

    Osteoporosis is a chronic inflammatory condition that is characterized by the loss of bone mineral density (BMD). The current study was undertaken to evaluate the impact of onion juice intake on the bone mineral density (BMD) and bone loss in corroboration with antioxidant effects in human (in vivo) as well as inhibitory effects on the differentiation of osteoclasts in the cell line (in vitro). For in vitro studies, the RAW 264.7 (osteoclast progenitor) cells were used to examine the anti-osteoclastogenic effect of onion. In the case of in vivo studies, twenty-four subjects were divided into two groups and advised to intake 100 mL of onion juice or placebo for 8 weeks. Anthropometric measurements and blood samples were collected at the initial, 2(nd), 6(th), 8(th) and 10(th) week. The result of in vitro studies indicated that onion extract would effectively inhibit the osteoclastogenesis and its differentiation. Significant changes in the levels of alkaline phosphatase (ALP), free radicals, total antioxidant capacity (TEAC) and various antioxidants were observed in onion administered subjects. The BMD of three postmenopausal women was also found to be mildly improved on supplementation with onion juice. Onion juice consumption showed a positive modulatory effect on the bone loss and BMD by improving antioxidant activities and thus can be recommended for treating various bone-related disorders, especially osteoporosis.

  11. History of the Belgian nuclear power controversy

    International Nuclear Information System (INIS)

    Laes, E.

    2009-01-01

    Partly because nuclear energy technology continues to provoke profound controversy, the Flemish institute for technology assessment (viWTA) took the initiative to order a study aimed at mapping out the historical dynamics of the societal debate on nuclear energy. This study was carried out by the Belgian Nuclear Research Centre (SCK-CEN, under the research programme PISA) together with the Free university of Brussels (VUB, research group MEKO) in 2004. In 2007, the report was updated and published by Acco (Leuven) under the title Kernenergie (on)besproken. This study had three main objectives: 1) to discuss the societal debate on nuclear energy in Belgium in relation to major events (Chernobyl, TMI, etc.); 2) to elucidate the role of social actors in the controversy on both a national and international level and 3) to discuss possible alternatives for a better structuring of the debate in the future, building on existing approaches

  12. Enhancing earwig populations in Belgian orchards.

    Science.gov (United States)

    Gobin, B; Marien, A; Davis, S; Leirs, H

    2006-01-01

    Earwigs are key generalist predators to a variety of orchard pests. However, the once held believe that earwigs damage and spoil fruits led to control strategies and eventually the loss of large earwig populations in Belgian orchards. In recent years, Integrated and Organic fruit growers have tried to re-establish earwig populations, thus far with little success. We started a study linking various components of orchard management and the earwig life history to identify potential periods in which earwigs are vulnerable and management factors hazardous to earwigs. As a first step, detailed knowledge of earwig phenology in orchards is necessary to identify vulnerable stages in the life cycle. Here we describe the first results from organic apple orchards.

  13. Focal epilepsy in the Belgian shepherd

    DEFF Research Database (Denmark)

    Berendt, Mette; Gulløv, Christina Hedal; Fredholm, Merete

    2009-01-01

    OBJECTIVES: To establish the mode of inheritance and describe the clinical features of epilepsy in the Belgian shepherd, taking the outset in an extended Danish dog family (199 individuals) of Groenendael and Tervueren with accumulated epilepsy. METHODS: Epilepsy positive individuals (living...... and deceased) were ascertained through a telephone interview using a standardised questionnaire regarding seizure history and phenomenology. Living dogs were invited to a detailed clinical evaluation. Litters more than five years of age, or where epilepsy was present in all offspring before the age of five......, were included in the calculations of inheritance. results: Out of 199 family members, 66 dogs suffered from epilepsy. The prevalence of epilepsy in the family was 33%. Fifty-five dogs experienced focal seizures with or without secondary generalisation, while four dogs experienced primary generalised...

  14. The Belgian National Seismic Monitoring Network

    Science.gov (United States)

    van Camp, M.; Lecocq, T.; Vanneste, K.; Rapagnani, G.; Martin, H.; Devos, F.; Bukasa, B.; Hendrickx, M.; Collin, F.; Camelbeeck, T.

    2009-04-01

    The Royal Observatory of Belgium (ROB) is responsible for the seismic activity monitoring in Belgium. For this purpose the ROB operates a network of 24 seismic stations. In addition 18 accelerographs have been installed since 2001 in the most seismic active zones. Seismometers allow detecting and localizing any earthquake of magnitude larger than 1.0 in Belgium and surrounding regions. The location of the accelerometric stations is chosen in function of the type of sub-soil and in some places in function of the nearness of important infrastructures as well. Seven seismic stations are now sending their data in real time to the Observatory (in Uccle) using ADSL lines. This will be increased in a near future. Among them 3 broad-band stations are also sending data to the ORFEUS and IRIS data centres. IRIS also receives data from the Belgian superconducting gravimeter. In addition, in 2010, a broadband borehole seismometer is to be installed at the Princess Elizabeth Antarctic station (71°57' S - 23°20' E), on the bedrock, 180 km away from the coastline. Recently a low-cost seismic alert system was developed for the Belgian territory, based on the connection flow on the ROB website (http://www.seismology.be), in parallel to an automatic control of the "Did you feel it ?" macroseismic inquiries, implemented in 2002. The alert is then confirmed at the latest by the seismic signals from five seismic stations that appear on the website with a delay of more or less ten minutes. It was successfully tested during the earthquake sequence that has been observed in the region at the southwest of Brussels since July 2008.

  15. Contact allergy caused by methylisothiazolinone: the Belgian-French experience.

    Science.gov (United States)

    Aerts, Olivier; Goossens, An; Giordano-Labadie, Françoise

    2015-01-01

    The chemical Kathon CG(®), a mixture of the preservatives methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI), was the leading cause of a worldwide epidemic of contact-allergic reactions in the eighties. From 2000 on, MI alone became allowed in industrial products and in 2005 authorities gave a green light for its use in leave-on and rinse-off cosmetics up to a maximum concentration of 100 ppm (0.01%). Following initial occupational cases, a continuously increasing number of consumers sensitized to MI have been reported and both Belgian and French allergy groups decided to routinely test MI in their baseline series from 2010 onwards. Two multicenter studies, comprising 8,680 and 7,874 patients in Belgium and France respectively, both clearly show the rise in contact allergy caused by MI, with a spectacular sensitization rate of ∼ 6.0% in 2012, even increasing to 7.0% in 2013. Mostly middle-aged women, presenting with facial-and/or hand dermatitis, were affected, although very young children were reported as well. Furthermore, the data confirmed that sensitization is primarily caused by cosmetics (mostly leave-on, but also rinse-off), household detergents and water-based paint. This unprecedented outbreak of contact sensitization to a preservative agent in Europe, and beyond, should have alerted the authorities much sooner and meanwhile the need for safer use concentrations of MI in cosmetics, detergents and industrial products is becoming more urgent every day.

  16. The attitudes of Belgian adolescents towards peers with disabilities

    NARCIS (Netherlands)

    Bossaert, Goele; Colpin, Hilde; Pijl, Sip Jan; Petry, Katja

    2011-01-01

    This study aimed to explore Belgian adolescents' attitudes towards peers with disabilities and to explore factors associated with these attitudes. Based on the theory of persuasive communication, this study focused on receiver variables (the "whom"), characteristics of students with disabilities

  17. A quality control exercise of radionuclide calibrators among Belgian hospitals

    International Nuclear Information System (INIS)

    Reher, D.F.G.; Merlo, P.

    1990-01-01

    On the initiative of the Belgian Association of Hospital Physicists, eleven Belgian hospitals participated in a quality control of radionuclide calibrators conducted in collaboration with the Central Bureau for Nuclear Measurements of the Commission of the European Communities. For practical reasons the nuclide 57 Co was chosen. The results from 20 different radionuclide calibrators show a fair agreement with a similar comparison carried out in 1980 in the UK. (orig.)

  18. [Analysis of diversity of vaginal microbiota in healthy Chinese women by using DNA-fingerprinting].

    Science.gov (United States)

    Xiao, Bing-bing; Liao, Qin-ping

    2012-04-18

    To analyze the diversity of healthy women's vaginal dominant flora in different physiological states with PCR-denaturing gradient gel electrophoresis (PCR-DGGE), to establish the basis for the future study of lower genital tract infections, and to provide a theoretical basis for the development of vaginal probiotics adapted to Chinese females. Women who underwent routine gynecologic examinations in Peking University First Hospital from October 2009 to January 2010 were enrolled, including 30 at reproductive age and 30 at post menopause age. Vaginal samples were collected and then total bacterial DNA was extracted. Universal bacterial primers were used to amplify the V3 region of 16S rDNA gene. PCR products were analyzed by denatured gradient gel electrophoresis (DGGE). Featured bands on DGGE were recovered, cloned and sequenced. Alignment with known sequence was made by using Blast on GenBank to identify bacterial strains so as to analyze the diversity of healthy women's vaginal dominant flora in different physiological states. (1) Vaginal flora in healthy Chinese women at their reproductive age were relatively simple, Lactobacillus were the dominant bacteria. Common bacteria included: Lactobacillus crispatus, Lactobacillus iners,and Lactobacillus gasseri. While L. iners were the dominant vaginal bacteria that could not be recognized by traditional method. (2) Vaginal bacteria in the women at post menopause age were more complex than in those at reproductive age. Common bacteria included: Lactobacillus iners, Lactobacillus crispatus, Escherichia coli, Streptococcus agalactiae, Streptococcus gallolyticus, Veillonella sp., Streptococcus intermedius, Streptococcus anginosus, Prevotella sp., Anaerococcus lactolyticus and Bacteroides fragilis. Based on the DGGE analysis, the most common vaginal bacteria in Chinese healthy women at reproductive age are Lactobacillus crispatus, Lactobacillus iners,and Lactobacillus gasseri. the most common vaginal bacteria in healthy post-menopausal

  19. Determinants of fracture risk in a UK-population-based cohort of older women: a cross-sectional analysis of the Cohort for Skeletal Health in Bristol and Avon (COSHIBA)

    OpenAIRE

    Clark, Emma M.; Gould, Virginia C.; Morrison, Leigh; Masud, Tahir; Tobias, Jon

    2011-01-01

    Background: identification of individuals with high fracture risk from within primary care is complex. It is likely that the true contribution of falls to fracture risk is underestimated. Methods: cross-sectional analysis of a population-based cohort of 3,200 post-menopausal women aged 73???4 years. Self-reported data were collected on fracture, osteoporosis clinical risk factors and falls/mobility risk factors. Self-reported falls were compared with recorded falls on GP computerised records....

  20. Belgian Photography: Towards a Minor Photography.

    Directory of Open Access Journals (Sweden)

    Jan Baetens

    2011-08-01

    Full Text Available

    Abstract: This article investigates Belgian photography from within the national framework. Using the notion of "banal nationalism" (Billig, it explores how even in the case of a nation widely perceived as non-existing , a nation in which the “official” national culture has completely eroded, the relationship between  photography and national culture are worth wile addressing. Furthermore, this text shows that Belgian photography, repeatedly described as having no schools, no centre, no towering figures, nor strong institutions, in short as lacking any positive identity, can not be approached in any essentializing way. In order to study the photographic production made in Belgium, new questions are needed, questions reaching beyond the traditional aesthetic questions of styles, masters, evolutions; questions that address the medium in its multiplicity and its context sensitiveness. This article tries to develop such a new set of questions by proposing a transfer of the notion of “minor literature” as it was theorized by Gilles Deleuze and Felix Guattari to the study of the photographic medium.

     

    Résumé: Le présent article examine la photographie belge du point de vue des liens entre culture et nation. En partant du concept de

  1. A hospital based study of biochemical markers of bone turnovers & bone mineral density in north Indian women

    Directory of Open Access Journals (Sweden)

    Ashok Kumar

    2013-01-01

    Full Text Available Background & objectives: The osteoporotic risk for women increases soon after menopause. Bone turnover markers are known to be associated with bone loss and fracture risk. This study was aimed to assess bone turnover using bone markers and their correlation with bone mineral density (BMD in pre- and post-menopausal women. Methods: A total of 255 healthy women (160 pre- and 95 post-menopausal were enrolled. Serum bone alkaline phosphatase (sBAP and serum N-terminal telopeptide of type I collagen (NTX were measured to evaluate the bone formation and resorption, respectively. Bone mineral density was determined at lumbar spine (L2-L4 anteroposteriorly, femoral neck and Ward′s triangle using Prodigy dual-energy X-ray absorptiometry (DXA system. The comparison of years since menopause with respect to BMD and bone markers was also evaluated. Results: NTX and sBAP showed significant negative correlation with BMD of femur neck and Ward′s triangle in postmenopausal women. BMD of all three sides were significant variables for NTX and BMD of femur neck and Ward′s triangle for sBAP in postmenopausal women. BMD lumbar spine was a significant variable for sBAP in premenopausal women. The mean values of NTX increased significantly with increase in the duration of years since menopause. The BMD of all three sides decreased significantly with increase in the duration of years since menopause. Interpretation & conclusions: Serum NTX and sBAP were inversely correlated to BMD of femur neck and Ward′s triangle in post-menopausal women. Simultaneous measurements of NTX and BMD in the north Indian women, suggest that bone resorption in women with low BMD remains high after menopause.

  2. Individual and environmental correlates of objectively measured sedentary time in Dutch and Belgian adults.

    Directory of Open Access Journals (Sweden)

    Femke van Nassau

    Full Text Available As the detrimental health effects of sedentary behaviour are well established, insight into the individual and environmental factors that influence adults' sedentary behaviour is needed. Most studies to date rely on self-reported measures of sedentary time. Therefore, the aim of the current study was to examine individual and environmental correlates of objectively measured sedentary time in Dutch and Belgian adults. Between March and August 2014, Belgian (n = 133 and Dutch (n = 223 adults, recruited as sub-sample of the SPOTLIGHT survey, wore an ActiGraph accelerometer to provide objectively measured sedentary and moderate to vigorous physical activity time. Participants completed a questionnaire assessing sociodemographic (country of residence, age, gender and educational level, lifestyle (sleep, smoking, sugar-containing beverage consumption, alcohol intake, health (body mass index, self-rated health, work (employment status and type of work, happiness, physical environmental (owning a car, number of screens, socioeconomic status and residential density and social environmental factors (social network, social cohesion. Univariate and multivariable regression analyses showed that Belgian participants had a lower odds of being sedentary for at least 9 hours per day compared to Dutch participants. Women, older participants and those meeting the WHO recommendation for physical activity were also less likely to sit for 9 hours or more per day. Participants doing (heavy manual work or being in education, homemaker, unemployed had lower odds of being sedentary for at least 9 hours per day compared to participants with a sitting job. Those with a higher self-reported social network also had lower odds for sedentary time. No associations between physical and other social environmental characteristics and sedentary time were found. Our findings add to the growing evidence of factors associated with prolonged sedentary time in adults. These findings may

  3. Inventory of nuclear liabilities - The Belgian perspective

    International Nuclear Information System (INIS)

    Minon, Jean-Paul

    2003-01-01

    Like all countries that use radioactive materials for producing electricity or for other peaceful purposes, Belgium is faced with an important challenge: the safe management of all these materials, in both the short and long term. Of course there is a price to pay for this management, which in accordance with the ethical principle of inter-generational fairness should be borne mainly by the current generations. However, it is possible that when the moment has come, the financial resources to cover the costs of decommissioning and remediation of these installations, prove to be insufficient or even completely non-existent: this then results in a nuclear liability. This kind of situation can have several causes, such as an underestimation of the actual costs by the operator or the owner of the nuclear installation or by the holder or the owner of the radioactive materials, negligence, transfer of ownership of the nuclear installation or the nuclear site without transfer of the corresponding provisions, a reduction in the operating time, a bankruptcy as well as ignorance. Because it wishes to avoid the occurrence of new nuclear liabilities, the Belgian legislator, by virtue of article 9 of the programme law of 12.12.97, charged ONDRAF/NIRAS, the Belgian Agency for Radioactive Waste and Enriched Fissile Materials, with collecting all the elements that are necessary in order to examine to which degree the decommissioning and remediation costs can be actually covered when the time comes. ONDRAF/NIRAS was specifically charged with ascertaining all facts of a technical and financial nature which should enable the minister responsible for energy to verify whether every operator or owner of a nuclear installation and every holder or owner of radioactive materials have provided in time for the requisite financial resources to cover the future costs of decommissioning and remediation. This evaluation of course also serves to enable the government to take the necessary

  4. The Belgian Nuclear Higher Education Network: Your way to the European Master in Nuclear Engineering

    International Nuclear Information System (INIS)

    Moons, F.; D'haeseleer, W.; Giot, M.

    2004-01-01

    BNEN, the Belgian Nuclear Higher Education Network has been created in 2001 by five Belgian universities and the Belgian Nuclear Research Centre (SCK CEN) as a joint effort to maintain and further develop a high quality programme in nuclear engineering in Belgium. More information: http://www.sckcen.be/BNEN. (author)

  5. A CO2-strategy for BTC [Belgian Development Agency

    Energy Technology Data Exchange (ETDEWEB)

    Bailly, J. [Prospect C and S, Brussels (Belgium); Hanekamp, E. [Partners for Innovation, Amsterdam (Netherlands)

    2008-09-15

    The CO2 footprint is determined the CO2 strategy is developed for the Belgian Technical Cooperation (BTC). BTC is the Belgian agency for development cooperation, and finances development projects in 23 partner countries. The CO2 footprint covered BTC's activities in 2007 in all their offices worldwide. Footprint and strategy were finalised and adopted by the Executive Board at the end of 2008. Meanwhile, the BTC began with the introduction of the proposed strategy. Partners for Innovation and Prospect were asked to support the introduction of the strategy and to determine the CO2 footprint of 2008.

  6. Modernity and the Belgian Congo | Fraiture | Tydskrif vir letterkunde

    African Journals Online (AJOL)

    This article will explore the intellectual context in which French-Belgian colonial writing developed from the turn of the twentieth century to the late 1930s. This period is marked by a gradual shift from evolutionism to cultural relativism. The analysis will first focus on the Tervuren colonial exhibition of 1897 and the progressive ...

  7. EC initiatives promise mixed blessings: a Belgian utility perspective

    International Nuclear Information System (INIS)

    Fraix, J.

    1992-01-01

    The potential effects on nuclear power of European Community initiatives are analysed from the viewpoint of a Belgian utility. The initiatives fall under the three broad headings of: East-West co-operation; completing the internal market; and carbon dioxide emission. (Author)

  8. Wabbes and the Milan Triennales: Representing the Belgian Nation

    NARCIS (Netherlands)

    Floré, F.M.W.; Ferran-Wabbes, Marie; Strauven, Iwan

    2012-01-01

    The work of the Brussels based furniture designer and interior architect Jules Wabbes played a significant role in the Belgian section of two successive Milan Triennials, that of 1957 and 1960. His sophisticated modern furniture and lightning designs were well qualified to represent the nation.

  9. The Relation Between Blood Lead Levels and Osteoporosis in Turkish Women

    Directory of Open Access Journals (Sweden)

    Nurver Turfaner Ertürk

    2004-03-01

    Full Text Available Lead is a toxic heavy element which is to 90% deposited in bone until the 6th decade and is given to the blood with pregnancy, lactation and physiologic osteoporosis. When it is over certain amounts it may cause osteoporosis and an increase in cardiac events and cancer. In order to evaluate the effect of menopause and osteoporosis on blood lead 20 post-menopausal osteoporotic, 19 non-osteoporotic and 21 pre-menopausal women were selected and their blood levels were measured. In post-menopausal women, its relation with bone mineral density was also investigated. There was no difference between osteoporotic and non-osteoporotic women and pre and postmenopausal women in terms of blood lead (Pb. There was no relation between age and Pb levels but in non-osteoporotic postmenopausal women there was a negative correlation between Pb levels and duration of menopause. There was no relation between bone mineral density and blood lead whereas blood lead and environmental pollution displayed a meaningful correlation.

  10. Assessment of marine debris on the Belgian Continental Shelf.

    Science.gov (United States)

    Van Cauwenberghe, Lisbeth; Claessens, Michiel; Vandegehuchte, Michiel B; Mees, Jan; Janssen, Colin R

    2013-08-15

    A comprehensive assessment of marine litter in three environmental compartments of Belgian coastal waters was performed. Abundance, weight and composition of marine debris, including microplastics, was assessed by performing beach, sea surface and seafloor monitoring campaigns during two consecutive years. Plastic items were the dominant type of macrodebris recorded: over 95% of debris present in the three sampled marine compartments were plastic. In general, concentrations of macrodebris were quite high. Especially the number of beached debris reached very high levels: on average 6429±6767 items per 100 m were recorded. Microplastic concentrations were determined to assess overall abundance in the different marine compartments of the Belgian Continental Shelf. In terms of weight, macrodebris still dominates the pollution of beaches, but in the water column and in the seafloor microplastics appear to be of higher importance: here, microplastic weight is approximately 100 times and 400 times higher, respectively, than macrodebris weight. Copyright © 2013 Elsevier Ltd. All rights reserved.

  11. Iron microbial communities in Belgian Frasnian carbonate mounds

    OpenAIRE

    Boulvain, F.; De Ridder, C.; Mamet, B.; Preat, A.; Gillan, D.

    2001-01-01

    The Belgian Frasnian carbonate mounds occur in three stratigraphic levels in an overall backstepping succession. Petit-Mont and Arche Members form the famous red and grey “marble” exploited for ornamental stone since Roman times. The evolution and distribution of the facies in the mounds is thought to be associated with ecologic evolution and relative sea-level fluctuations. Iron oxides exist in five forms in the Frasnian mounds; four are undoubtedly endobiotic organized structures: (1) micro...

  12. The Odd One Out? Revisiting the Belgian Welfare State

    Directory of Open Access Journals (Sweden)

    Cor Wagenaar

    2014-08-01

    Full Text Available Michael Ryckewaert publication Building the Economic Backbone of the Belgian Welfare State. Infrastructure, planning and architecture 1945-1973 describes the evolution of the welfare state and Belgium, more specifically its spatial characteristics. This by now historical socio-political model had decidedly collectivist traits, culminating in the provision of social security networks and a vast expansion of the public domain. If collectivism was one of the key elements of the welfare state, the absence of centralized planning appears to make the Belgian variant somewhat problematic.Whereas in countries like the Netherlands, Germany and France, modernism became the house style of the welfare state, thanks to the massive investments in public housing, this did not happen in Belgium. Here, the De Taeye Act of 1948 sponsored the construction of individual, detached houses; not surprisingly, most clients preferred traditional architecture and refrained from modern experiments. Industrial parks, office buildings and shops, on the other hand, developed into the cornerstones of Belgian modern architecture after 1945. Both the low-density sprawl and the industrial parks depend heavily on the use of the car, which was accommodated by the construction of a network of highways.

  13. Belgium’s expansionist history between 1870 and 1930: imperialism and the globalisation of Belgian business

    OpenAIRE

    Abbeloos, Jan-Frederik

    2008-01-01

    This chapter considers if and how the political action of imperialism and the globalisation of business influenced each other in Belgium between 1870 and 1930. In addition to the role that Belgian King Leopold II played in the territorial partition of Africa and the opening up of China, the period sees a growing amount of capital and industrial know-how from Belgium being invested in markets outside Europe. Before World War I, the globalisation of Belgian business and Belgian imperialism oper...

  14. Health risks in the cleaning industry: a Belgian census-linked mortality study (1991-2011).

    Science.gov (United States)

    Van den Borre, Laura; Deboosere, Patrick

    2018-01-01

    Cleaning work has been associated with a wide range of occupational health hazards. However, little is known about mortality risks in the cleaning industry. This study examines differences in cause-specific mortality between cleaners, manual and non-manual workers. Using exhaustive census-linked mortality data, the total Belgian working population aged 30-60 was selected from the 1991 census. Analyses were based on 202,339 male and 58,592 female deaths between 1 March 1991 and 31 December 2011. Standardized Mortality Ratios were calculated and indirectly adjusted for smoking (SMR). In addition, Cox proportional hazards regression models were used to account for age, educational level, part-time employment and marital status. Large mortality differences were observed between cleaners, manual and non-manual workers. In 2001-2011, smoking-adjusted SMRs for all-cause mortality were higher among cleaners than among non-manual workers (Men 1.25 CI 1.22-1.28; women 1.10 CI 1.07-1.13). SMRs also show cleaners had significantly more deaths due to COPD (men 2.13 CI 1.92-2.37; women 2.03 CI 1.77-2.31); lung cancer (men 1.31 CI 1.22-1.39; women 1.21 CI 1.11-1.32); pneumonia (men 1.64 CI 1.35-1.97; women 1.31 CI 1.00-1.68); ischaemic heart diseases (men 1.22 CI 1.13-1.31; women 1.40 CI 1.25-1.57) and cerebrovascular diseases (men 1.19 CI 1.05-1.35; women 1.13 CI 1.00-1.27). Mortality risks among cleaners remained elevated after adjustment for education. Respiratory and cardiovascular mortality is considerably higher for male and female cleaners than for non-manual workers.

  15. Association between bone mineral density and low backache in postmenopausal women

    International Nuclear Information System (INIS)

    Qayum, M.; Ali, W.

    2017-01-01

    Objective: To determine association between bone mineral density (BMD) and low backache in post menopausal women in general population of Lahore. Study Design: Descriptive study. Place and Duration of Study: Gynaecological outpatint department of Punjab Rangers Hospital Lahore during the period, from Feb 2015 to Feb 2016. Material and Methods: Screening for association between BMD and low backache in 481 post menopausal women was carried out. Low back pain was considered clinically relevant if the patient complained of moderate to severe pain, or if the patient needed any medical treatment. Their BMD was measured. The measurement site for BMD was the calcaneus of patient. The diagnosis was based on T score. Data was analyzed. Result: Osteoporosis was found in 303 (88.3%) of 50-60 years age group and 40 (11.7%) of 61-plus years age group. Conclusion: Bone mineral density was significantly lower in postmenopausal women and there was a strong association between low back ache and decreased BMD value. (author)

  16. Changes in physical activity, sedentary time, and risk of falling: The Women's Health Initiative Observational Study.

    Science.gov (United States)

    Bea, Jennifer W; Thomson, Cynthia A; Wallace, Robert B; Wu, Chunyuan; Seguin, Rebecca A; Going, Scott B; LaCroix, Andrea; Eaton, Charles; Ockene, Judith K; LaMonte, Michael J; Jackson, Rebecca; Jerry Mysiw, W; Wactawski-Wende, Jean

    2017-02-01

    Falling significantly affects quality of life, morbidity, and mortality among older adults. We sought to evaluate the prospective association between sedentary time, physical activity, and falling among post-menopausal women aged 50-79years recruited to the Women's Health Initiative Observational Study between 1993 and 1998 from 40 clinical centers across the United States. Baseline (B) and change in each of the following were evaluated at year 3 (Y3) and year 6 (Y6; baseline n=93,676; Y3 n=76,598; Y6 n=75,428): recreational physical activity (MET-h/wk), sitting, sleeping (min/day), and lean body mass by dual energy X-ray absorptiometry (subset N=6475). Falls per year (0, 1, 2, ≥3) were assessed annually by self-report questionnaire and then dichotomized as ≤1 and ≥2falls/year. Logistic regression models were adjusted for demographics, body mass index, fall history, tobacco and alcohol use, medical conditions, and medications. Higher baseline activity was associated with greater risk of falling at Y6 (18%; p for trend resistance training, should be evaluated to assist post-menopausal women in reaching or maintaining levels of aerobic activity known to prevent and manage several chronic diseases. Copyright © 2016 Elsevier Inc. All rights reserved.

  17. BNAIC 2008 : Proceedings of BNAIC 2008, the twentieth Belgian-Dutch Artificial Intelligence Conference

    NARCIS (Netherlands)

    Nijholt, Anton; Pantic, Maja; Poel, Mannes; Hondorp, Hendri

    2008-01-01

    This book contains the proceedings of the 20th edition of the Belgian-Netherlands Conference on Artificial Intelligence. The conference was organized by the Human Media Interaction group of the University of Twente. As usual, the conference was under the auspices of the Belgian-Dutch Association for

  18. The actual practice of air cleaning in Belgian nuclear facilities

    Energy Technology Data Exchange (ETDEWEB)

    Goossens, W.R. [PEGO, Mol (Belgium)

    1995-02-01

    With 60% of its power generation from nuclear stations Belgium has 7 nuclear power stations in operation with a total capacity of 5.4 MWe. Enriched uranium is imported and converted to fuel assemblies. The actinides of reprocessed fuel are recycled as MOX fuel. A main waste conditioning operation has been performed in the PAMELA vitrifier. The actual practice of nuclear air cleaning in the Belgian PWR station DOEL-4 and in the PAMELA -vitrification plant for high level liquid waste is reviewed.

  19. Operating experience with diesel generators in Belgian nuclear power plants

    International Nuclear Information System (INIS)

    Merny, R.

    1986-01-01

    Various problems have occurred on the diesel generators in the Belgian nuclear power plants, independently of the D.G. manufacturer or from the operating crew. Furthermore no individual part of the D.G. can be incriminated as being the main cause of the incidents. The incidents reported in this paper are chosen because of the importance for the safety or for the long repair period. The unavailability of a D.G. can only be detected by periodic tests and controls. Combined with a good preventive maintenance, the risks of incidents can be reduced. (author)

  20. Immune activation in HIV-infected aging women on antiretrovirals--implications for age-associated comorbidities: a cross-sectional pilot study.

    Directory of Open Access Journals (Sweden)

    Maria L Alcaide

    Full Text Available Persistent immune activation and microbial translocation associated with HIV infection likely place HIV-infected aging women at high risk of developing chronic age-related diseases. We investigated immune activation and microbial translocation in HIV-infected aging women in the post-menopausal ages.Twenty-seven post-menopausal women with HIV infection receiving antiretroviral treatment with documented viral suppression and 15 HIV-negative age-matched controls were enrolled. Levels of immune activation markers (T cell immune phenotype, sCD25, sCD14, sCD163, microbial translocation (LPS and biomarkers of cardiovascular disease and impaired cognitive function (sVCAM-1, sICAM-1 and CXCL10 were evaluated.T cell activation and exhaustion, monocyte/macrophage activation, and microbial translocation were significantly higher in HIV-infected women when compared to uninfected controls. Microbial translocation correlated with T cell and monocyte/macrophage activation. Biomarkers of cardiovascular disease and impaired cognition were elevated in women with HIV infection and correlated with immune activation.HIV-infected antiretroviral-treated aging women who achieved viral suppression are in a generalized status of immune activation and therefore are at an increased risk of age-associated end-organ diseases compared to uninfected age-matched controls.

  1. Risk factors for high blood pressure in women attending menopause clinics in Italy.

    Science.gov (United States)

    2006-01-10

    We analysed risk factors for high blood pressure (BP) among women around menopause. Eligible women were consecutively attending first-level outpatient menopause clinics in Italy for general counseling or treatment of menopausal symptoms. During the visit BP was measured three times. The mean of second and third of the three diastolic BP values for women was >90mm of mercury and/or reporting any current pharmacological treatment for high BP were considered hypertensive. Out of 45,204 women who entered the study with information on blood pressure, 12,150 had high BP. The odds ratios (OR) of high BP increased with age: in comparison with women aged or =58, respectively. Women with high BP were less educated than those without (OR education >12 versus 26. In comparison with women reporting no regular physical activity, the multivariate OR of high BP was 0.93 (95% CI, 0.87-0.99) for women reporting regular activity. In comparison with peri-menopausal women, post-menopausal women were at increased risk (OR 1.14, 95% CI, 1.03-1.24) and the risk tended to increase with age at menopause. Current use of hormonal replacement therapy (HRT) was associated with a lower risk of high BP (OR 0.88, 95% CI, 0.84-0.94). This large cross-sectional study suggests that, after taking into account the effect of age, post-menopausal women are at greater risk of high BP, but current HRT use slightly lowers the risk. Other determinants of high BP were low level of education, overweight, and low level of physical activity.

  2. Technical improvements in 19th century Belgian window glass production

    Science.gov (United States)

    Lauriks, Leen; Collette, Quentin; Wouters, Ine; Belis, Jan

    Glass was used since the Roman age in the building envelope, but it became widely applied together with iron since the 19th century. Belgium was a major producer of window glass during the nineteenth century and the majority of the produced window glass was exported all over the world. Investigating the literature on the development of 19th century Belgian window glass production is therefore internationally relevant. In the 17th century, wood was replaced as a fuel by coal. In the 19th century, the regenerative tank furnace applied gas as a fuel in a continuous glass production process. The advantages were a clean production, a more constant and higher temperature in the furnace and a fuel saving. The French chemist Nicolas Leblanc (1787-1793) and later the Belgian chemist Ernest Solvay (1863) invented processes to produce alkali out of common salt. The artificial soda ash improved the quality and aesthetics of the glass plates. During the 19th century, the glass production was industrialized, influencing the operation of furnaces, the improvement of raw materials as well as the applied energy sources. Although the production process was industrialized, glassblowing was still the work of an individual. By improving his work tools, he was able to create larger glass plates. The developments in the annealing process followed this evolution. The industry had to wait until the invention of the drawn glass in the beginning of the 20th century to fully industrialise the window glass manufacture process.

  3. Multiple sclerosis in Belgian children: A multicentre retrospective study.

    Science.gov (United States)

    Verhelst, Helene; De Waele, Liesbeth; Deconinck, Nicolas; Ceulemans, Berten; Willekens, Barbara; Van Coster, Rudy

    2017-03-01

    Although the diagnosis of multiple sclerosis (MS) in the paediatric population remains challenging, paediatric-onset MS is increasingly recognized worldwide. We report on the clinical and biochemical features of a Belgian multicentre cohort of paediatric MS patients in a national retrospective descriptive study. Twenty one paediatric MS patients from four Belgian University Hospitals were included. In nine patients, onset of MS was before the age of ten years which makes the study cohort of special interest. We report a higher incidence of acute disseminated encephalomyelitis (ADEM)-like first MS attacks and an overall higher proportion of polysymptomatic episodes than in adult and most paediatric cohorts reported in the literature. The clinical presentation in our cohort was rather severe with high median EDSS-score during the first clinical manifestation and barely more than half of our study patients showing full recovery after their first clinical manifestation. Also, a significant proportion of children in our cohort has severe disease progression despite disease modifying therapy and 9.5% of patients showed transition to secondary progressive multiple sclerosis during adolescence. An early and correct diagnosis of paediatric MS is essential to start early adequate treatment. As illustrated by our study cohort, current treatment options in childhood are unsatisfactory. Copyright © 2016 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.

  4. Pyrrolizidine alkaloids in food and feed on the Belgian market.

    Science.gov (United States)

    Huybrechts, Bart; Callebaut, Alfons

    2015-01-01

    Pyrrolizidine alkaloids (PAs) are widely distributed plant toxins with species dependent hepatotoxic, carcinogenic, genotoxic and pneumotoxic risks. In a recent European Food Safety Authority (EFSA) opinion, only two data sets from one European country were received for honey, while one feed data set was included. No data are available for food or feed samples from the Belgian market. We developed an LC-MS/MS method, which allowed the detection and quantification of 16 PAs in a broad range of matrices in the sub ng g(-1) range. The method was validated in milk, honey and hay and applied to honey, tea (Camellia sinensis), scented tea, herbal tea, milk and feed samples bought on the Belgian market. The results confirmed that tea, scented tea, herbal tea and honey are important food sources of pyrrolizidine alkaloid contamination in Belgium. Furthermore, we detected PAs in 4 of 63 commercial milk samples. A high incidence rate of PAs in lucerne (alfalfa)-based horse feed and in rabbit feed was detected, while bird feed samples were less contaminated. We report for the first time the presence of monocrotaline, intermedine, lycopsamine, heliotrine and echimidine in cat food.

  5. Care coordination in bone health screening between individual behaviors and health care services among Korean-American women across three age groups

    Directory of Open Access Journals (Sweden)

    Young-Shin Lee

    2017-01-01

    Full Text Available Integrated continuous care is important to prevent and treat brittle bone status in the aging process; however, minority groups often have limited access to health services. The purpose of this study was to identify the care coordination among women’s perceptions about their bone health, information from health care providers, and the results of Bone Mineral Density (BMD tests across three age groups. The study was a cross-sectional comparative design. A total of 63 Korean American women completed both the assessment of BMD of the femoral neck and an interview survey. One’s own risks of osteoporosis, screening behaviors, and health care providers’ advice were analyzed according to three age (pre-, peri-, and post-menopausal groups, BMD levels, and health insurance coverage. Overall, health insurance coverage and having a primary health care provider of Korean American women were 59.0% and 32.0%, respectively; 61.9% had lower than normal BMD levels, which were significantly increased by advanced age. Individual awareness of risks of osteoporosis and screening behaviors were significantly higher in peri-menopausal than in pre- and post-menopausal groups, but no differences were found in health care providers’ information. The awareness and care providers’ information by BMD level or health insurance did not differ. The findings show a discrepancy between individual perceptions and behaviors and health care providers’ recommendations regard to bone health. Health behaviors should be guided by professional health care providers. The women in the post-menopausal stage need to be educated about the high risk of osteoporosis and its management.

  6. Thyroid-Stimulating Hormone (TSH) Concentration at Birth in Belgian Neonates and Cognitive Development at Preschool Age.

    Science.gov (United States)

    Trumpff, Caroline; De Schepper, Jean; Vanderfaeillie, Johan; Vercruysse, Nathalie; Van Oyen, Herman; Moreno-Reyes, Rodrigo; Tafforeau, Jean; Vanderpas, Jean; Vandevijvere, Stefanie

    2015-11-02

    The main objective of the study was to investigate the effect of MID during late pregnancy, assessed by the thyroid-stimulating hormone (TSH) concentration at neonatal screening, on cognitive development of preschool children. A retrospective cohort study including 311 Belgian preschool children of 4-6 years old was conducted. Children were selected at random from the total list of neonates screened in 2008, 2009, and 2010 by the Brussels new-born screening center. Infants with congenital hypothyroidism, low birth weight, and/or prematurity were excluded from the selection. The selected children were stratified by gender and TSH-range (0.45-15 mIU/L). Cognitive abilities were assessed using Wechsler Preschool and Primary Scale of Intelligence-third edition. In addition, several socioeconomic, parental, and child confounding factors were assessed. Neonatal TSH concentration-a surrogate marker for MID-was not associated with Full Scale and Performance IQ scores in children. Lower Verbal IQ scores were found in children with neonatal TSH values comprised between 10-15 mIU/L compared to lower TSH levels in univariate analysis but these results did not hold when adjusting for confounding factors. Current levels of iodine deficiency among pregnant Belgian women may not be severe enough to affect the neurodevelopment of preschool children.

  7. Thyroid-Stimulating Hormone (TSH Concentration at Birth in Belgian Neonates and Cognitive Development at Preschool Age

    Directory of Open Access Journals (Sweden)

    Caroline Trumpff

    2015-11-01

    Full Text Available The main objective of the study was to investigate the effect of MID during late pregnancy, assessed by the thyroid-stimulating hormone (TSH concentration at neonatal screening, on cognitive development of preschool children. A retrospective cohort study including 311 Belgian preschool children of 4–6 years old was conducted. Children were selected at random from the total list of neonates screened in 2008, 2009, and 2010 by the Brussels new-born screening center. Infants with congenital hypothyroidism, low birth weight, and/or prematurity were excluded from the selection. The selected children were stratified by gender and TSH-range (0.45–15 mIU/L. Cognitive abilities were assessed using Wechsler Preschool and Primary Scale of Intelligence—third edition. In addition, several socioeconomic, parental, and child confounding factors were assessed. Neonatal TSH concentration—a surrogate marker for MID—was not associated with Full Scale and Performance IQ scores in children. Lower Verbal IQ scores were found in children with neonatal TSH values comprised between 10–15 mIU/L compared to lower TSH levels in univariate analysis but these results did not hold when adjusting for confounding factors. Current levels of iodine deficiency among pregnant Belgian women may not be severe enough to affect the neurodevelopment of preschool children.

  8. Response rates to oestrogen treatment in perimenopausal women

    DEFF Research Database (Denmark)

    Rejnmark, Lars; Vestergaard, P; Tofteng, Charlotte L.

    2004-01-01

    OBJECTIVE: To characterise women with no response or with a good response to hormone replacement therapy (HRT), evaluated by change in bone mineral density (BMD). Design: Nested case-control study within a comprehensive cohort study. SUBJECTS AND METHODS: In the Danish Osteoporosis Prevention Study...... responders according to changes in BMD of the femoral neck and lumbar spine, respectively. Combining measuring sites, 2.6% were non-responders and 20% were good responders. Non-responders at the femoral neck were more often smokers and had a lower spine BMD. Good responders were older, had a higher body...... weight, and higher alcohol consumption. In addition, good responders at both measurements sites had a lower BMD at the total hip. CONCLUSION: A favourable BMD response to HRT can be expected in most post-menopausal women especially if they are non-smokers with a moderate--as opposed to low...

  9. Annual report for the steering committee of the association Euratom-Belgian State for fusion 1998

    Energy Technology Data Exchange (ETDEWEB)

    Decreton, M

    1998-10-01

    This report is prepared for the annual steering committee meting of the Association Euratom - Belgian State in the area of fusion reactor technology. The Belgian contribution focuses on the assessment of the first wall and blanket materials under radiation and coolant interaction and on developments for the remote handling in maintenance activities. The period October 1997 to September 1998 is reported on.The fusion technology work performed at the Belgian Nuclear Research Centre SCK/CEN, the Department of Metallurgy and Materials Engineering of the Louvain University (Belgium) and S.A. Gradel, a Luxemburg-based organisation, is described.

  10. Annual report for the steering committee of the association Euratom-Belgian State for fusion 1998

    International Nuclear Information System (INIS)

    Decreton, M.

    1998-10-01

    This report is prepared for the annual steering committee meting of the Association Euratom - Belgian State in the area of fusion reactor technology. The Belgian contribution focuses on the assessment of the first wall and blanket materials under radiation and coolant interaction and on developments for the remote handling in maintenance activities. The period October 1997 to September 1998 is reported on.The fusion technology work performed at the Belgian Nuclear Research Centre SCK/CEN, the Department of Metallurgy and Materials Engineering of the Louvain University (Belgium) and S.A. Gradel, a Luxemburg-based organisation, is described

  11. Annual report for the steering committee of the association Euratom-Belgian State for fusion 1999

    International Nuclear Information System (INIS)

    Decreton, M.

    1999-10-01

    This report is prepared for the annual steering committee meting of the Association Euratom - Belgian State in the area of fusion reactor technology. The Belgian contribution focuses on the assessment of the first wall and blanket materials under radiation and coolant interaction and on developments for the remote handling in maintenance activities. The period October 1998 to September 1999 is reported on.The fusion technology work performed at the Belgian Nuclear Research Centre SCK/CEN, the Department of Metallurgy and Materials Engineering of the Louvain University (Belgium) and S.A. Gradel, a Luxemburg-based organisation, is described

  12. Annual report for the steering committee of the association Euratom-Belgian State for fusion 1999

    Energy Technology Data Exchange (ETDEWEB)

    Decreton, M

    1999-10-01

    This report is prepared for the annual steering committee meting of the Association Euratom - Belgian State in the area of fusion reactor technology. The Belgian contribution focuses on the assessment of the first wall and blanket materials under radiation and coolant interaction and on developments for the remote handling in maintenance activities. The period October 1998 to September 1999 is reported on.The fusion technology work performed at the Belgian Nuclear Research Centre SCK/CEN, the Department of Metallurgy and Materials Engineering of the Louvain University (Belgium) and S.A. Gradel, a Luxemburg-based organisation, is described.

  13. Comparison of HE4, CA125 and ROMA algorithm in women with a pelvic mass: correlation with pathological outcome.

    Science.gov (United States)

    Sandri, M T; Bottari, F; Franchi, D; Boveri, S; Candiani, M; Ronzoni, S; Peiretti, M; Radice, D; Passerini, R; Sideri, M

    2013-02-01

    The quality of first surgery is one of the most important prognostic factors in ovarian cancer patients. Pre-surgical distinction of benign and malignant pelvic mass plays a critical role in ovarian cancer management and survival. The aim of this study was to evaluate the clinical performance of ROMA algorithm and of CA125 and HE4 in the triage of patients with a pelvic mass undergoing surgery, in order to discriminate benign from malignant disease. Three hundred and forty-nine pre- and post-menopausal women, aged 18 years or older undergoing surgery because of a pelvic mass were enrolled: serum concentrations of CA125 and HE4 were determined and ROMA was calculated for each sample. Median serum CA125 and HE4 levels were higher in patients with EOC compared to subjects with benign disease (p<0.0001). The resultant accuracy (using Receiver Operating Characteristics, ROC Area) values for HE4, CA125 and ROMA showed a good performance ranging from 89.8% for CA125 in pre-menopausal patients to 93.3% for ROMA in post-menopausal patients: AUC for ROMA resulted significantly higher in comparison to CA125 alone (93.3% vs 90.3%, p=0.0018) in post menopausal patients. A sub-analysis considering the 40 patients with endometrioid disease showed the highest accuracy of HE4 in these patients. Data presented confirm the accuracy of HE4 and of the ROMA algorithm in the distinction of ovarian carcinoma from benign disease, with a trend towards better performance for ROMA than for CA125 alone, statistically significant in postmenopausal patients. Copyright © 2012 Elsevier Inc. All rights reserved.

  14. Belgian Workshop (November 2003) - Executive Summary and International Perspective

    International Nuclear Information System (INIS)

    2004-01-01

    The fourth workshop of the OECD/NEA Forum on Stakeholder Confidence (FSC) was hosted by ONDRAF/NIRAS, the Belgian Agency for Radioactive Waste Management and enriched fissile materials. The central theme of the workshop was 'Dealing with interests, values and knowledge in managing risk' within the Belgian context of local partnerships for the long term management of low-level, short-lived radioactive waste. The four-day workshop started with a half-day session in Brussels giving a general introduction on the Belgian context and the local partnership methodology. This was followed by community visits to three local partnerships, PaLoFF in Fleurus-Farciennes, MONA in Mol, and STOLA in Dessel. After the visits, the workshop continued with two full-day sessions in Brussels. One hundred and nineteen registered participants, representing 13 countries, attended the workshop or participated in the community visits. About two thirds were Belgian stakeholders; the remainder came from FSC member organisations. The participants included representatives of municipal governments, civil society organisations, government agencies, industrial companies, the media, and international organisations as well as private citizens, consultants and academics. The four-day meeting was structured as follows: Day 1 morning was devoted to introductory presentations. Information was given on the general radioactive waste management context in Belgium. Regarding the management of LLW, and in particular the search for a disposal facility site, the workshop heard about the local partnership methodology developed by university researchers of the University of Antwerp and the Fondation Universitaire Luxembourgeoise (FUL). These partnerships between the potential host municipalities and the radwaste agency have the mission to develop an integrated facility proposal adapted to local conditions. Community visits took place on Day 1 afternoon and Day 2. Visits offered an opportunity for

  15. Characteristics of suicide hotspots on the Belgian railway network.

    Science.gov (United States)

    Debbaut, Kevin; Krysinska, Karolina; Andriessen, Karl

    2014-01-01

    In 2004, railway suicide accounted for 5.3% of all suicides in Belgium. In 2008, Infrabel (Manager of the Belgian Railway Infrastructure) introduced a railway suicide prevention programme, including identification of suicide hotspots, i.e., areas of the railway network with an elevated incidence of suicide. The study presents an analysis of 43 suicide hotspots based on Infrabel data collected during field visits and semi-structured interviews conducted in mental health facilities in the vicinity of the hotspots. Three major characteristics of the hotspots were accessibility, anonymity, and vicinity of a mental health institution. The interviews identified several risk and protective factors for railway suicide, including the training of staff, introduction of a suicide prevention policy, and the role of the media. In conclusion, a comprehensive railway suicide prevention programme should continuously safeguard and monitor hotspots, and should be embedded in a comprehensive suicide prevention programme in the community.

  16. The German and Belgian accreditation models for diabetic foot services.

    Science.gov (United States)

    Morbach, Stephan; Kersken, Joachim; Lobmann, Ralf; Nobels, Frank; Doggen, Kris; Van Acker, Kristien

    2016-01-01

    The International Working Group on the Diabetic Foot recommends that auditing should be part of the organization of diabetic foot care, the efforts required for data collection and analysis being balanced by the expected benefits. In Germany legislature demands measures of quality management for in- and out-patient facilities, and, in 2003, the Germany Working Group on the Diabetic Foot defined and developed a certification procedure for diabetic foot centres to be recognized as 'specialized'. This includes a description of management facilities, treatment procedures and outcomes, as well as the organization of mutual auditing visits between the centres. Outcome data is collected at baseline and 6 months on 30 consecutive patients. By 2014 almost 24,000 cases had been collected and analysed. Since 2005 Belgian multidisciplinary diabetic foot clinics could apply for recognition by health authorities. For continued recognition diabetic foot clinics need to treat at least 52 patients with a new foot problem (Wagner 2 or more or active Charcot foot) per annum. Baseline and 6-month outcome data of these patients are included in an audit-feedback initiative. Although originally fully independent of each other, the common goal of these two initiatives is quality improvement of national diabetic foot care, and hence exchanges between systems has commenced. In future, the German and Belgian accreditation models might serve as templates for comparable initiatives in other countries. Just recently the International Working Group on the Diabetic Foot initiated a working group for further discussion of accreditation and auditing models (International Working Group on the Diabetic Foot AB(B)A Working Group). Copyright © 2016 John Wiley & Sons, Ltd.

  17. Assessment of doses received by the Belgian population due to the Chernobyl releases

    International Nuclear Information System (INIS)

    Govaerts, P.; Fieuw, G.; Deworm, J.P.; Zeevaert, Th.

    1986-01-01

    The consequences of the exposure during the first year and beyond the first year after the Chernobyl accident in terms of radiation effects on the Belgian population are discussed as well as some uncertainties in these evaluations. (A.F.)

  18. Annual report for the steering committee of the association Euratom-Belgian State for fusion 1996

    Energy Technology Data Exchange (ETDEWEB)

    Moons, F.; Bogaerts, W.; Decreton, M.; Biver, E.; Coenen, S.; Benoit, Ph.; Coheur, L.; Deboodt, P.; Andreev, D.

    1996-09-01

    This report is prepared for the annual steering committee meting of the Association Euratom - Belgian State for Fusion. The period October 1995 to September 1996 is reported on.The fusion technology work performed at the Belgian Nuclear Research Centre SCK/CEN, the Department of Metallurgy and Materials Engineering of the Louvain University (Belgium) and S.A. Gradel, a Luxemburg company, is described.

  19. Annual report for the steering committee of the association Euratom-Belgian State for fusion 1996

    International Nuclear Information System (INIS)

    Moons, F.; Bogaerts, W.; Decreton, M.; Biver, E.; Coenen, S.; Benoit, Ph.; Coheur, L.; Deboodt, P.; Andreev, D.

    1996-09-01

    This report is prepared for the annual steering committee meting of the Association Euratom - Belgian State for Fusion. The period October 1995 to September 1996 is reported on.The fusion technology work performed at the Belgian Nuclear Research Centre SCK/CEN, the Department of Metallurgy and Materials Engineering of the Louvain University (Belgium) and S.A. Gradel, a Luxemburg company, is described

  20. A longitudinal study of survival in belgian shepherds with genetic epilepsy

    DEFF Research Database (Denmark)

    Gulløv, Christina Hedal; Toft, Nils; Berendt, Mette

    2012-01-01

    Belgian Shepherds have focal genetic epilepsy. The prevalence of epilepsy has been estimated as 9.5% in the breed and as 33% in the family investigated. Dogs with epilepsy might have an increased risk of premature death.......Belgian Shepherds have focal genetic epilepsy. The prevalence of epilepsy has been estimated as 9.5% in the breed and as 33% in the family investigated. Dogs with epilepsy might have an increased risk of premature death....

  1. Performance of X-ray absorptiometry in post-menopausal vertebral osteoporosis. Discriminant value of vertebral and femoral measurements, fracture threshold, reproducibility. Performances de l'absorptiometrie a rayons X dans l'osteoporose vertebrale post-menopausique

    Energy Technology Data Exchange (ETDEWEB)

    Pouilles, J.M.; Tremollieres, F.; Ribot, C. (Hopital Purpan, 31 - Toulouse (FR))

    1990-12-01

    The aim of this study was to assess the performance of a new bone densitometry technique, X-ray absorptiometry, in vertebral osteoporosis with fracture(s). Vertebral and femoral (neck, Ward's triangle and trochanter) bone density was measured in 60 women with at least one vertebral compression fracture of osteoporotic origin (mean age: 61), 100 controls of the same age and in 40 young adults (mean age: 30). Osteoporosis patients had significantly (p<0.0005) low bone density values in comparison with the young adults. Measurements using the spine and Ward's triangle had the best discriminant values assessed by the ROC (Receiver Operating Characteristics) technique (areas under the curve: 95% and 84% respectively). The fracture threshold was fixed at a vertebral bone density of 0.78 g/cm{sup 2}, this value giving the best compromise between sensitivity (83%) and specificity (95%) with 91% of subjects appropriately classifed. Reproducibility was assessed in the short term in 9 osteoporosis patients. The mean standard deviation of measurements was 0.017 g/cm{sup 2} (coefficient of variation: 2.6%) as compared with 0.010 g/cm{sup 2} (coefficient of variation: 0.8%) in the young adult. These results emphasise the true advance represented by X-ray absorptiometry in the area of bone densitometry, notably in the assessment and monitoring of demineralisation disorders.

  2. Importance of physical examination in early detection of lump in breast in women of different age groups

    International Nuclear Information System (INIS)

    Abbas, H.; Imran, S.; Waris, Noorul-ain-Hafeez; Khanam, A.; Khurshid, R.

    2010-01-01

    Background: The spectrum of breast lesions in adolescents varies markedly from that for adults, with the former lesions being overwhelmingly benign. Fine needle biopsy can be used to distinguish benign and malignant tumour. Study Design: This study examined the characteristics and outcome of women with different age groups in whom physical examination was their sole method of lump in breast detection. Patients and Methods: A total of 200 patients were included in the study. These were divided into 3 groups. Group A was consisting of 75 girls with age of pubescent. Group B included 69 suspected breast cancer women with age range 26-38 years. Fifty-six suspected breast cancer women with age range 41-60 year were included as group C. Study was carried out in patients admitted in the Department/Out-door of Surgery, Sir Ganga Ram Hospital, Lahore, Pakistan. Study period was 6 months. All women received a physical examination by a breast surgeon. Proforma including demographic and clinical characteristics were filled. The diagnosis for patients in this study was achieved by core needle biopsy using a 14-gauge cutting needle. Results: It was observed that early age at menarche ( 25 may be a risk factor in peri/post menopausal women. Active life style is more important with increasing age as it decreases the risk of developing tumour state. Family history was more common in women with peri/post menopausal status as compared to other age groups. Clinical characteristics showed that lump size <2.5 cm was more common in both pubescent and reproductive age. While lump size with a range of 2.5-5.0 cm, was observed in all groups of patients. Fibroadenoma is observed in almost all women with pubescent age while both benign and malignant tumour observed in women with reproductive age. Malignant tumour was observed mostly in women with peri/post menopausal status. Conclusion: Study concluded that early detection or clinical examination with FNA cut out the patients from harassment

  3. Cooking up a culinary identity for Belgium. Gastrolinguistics in two Belgian cookbooks (19th century).

    Science.gov (United States)

    Parys, Nathalie

    2013-12-01

    The notion of cookbooks as socio-historic markers in a society is generally accepted within food studies. As both representations and prescriptions of food practices, perceived habits and attitudes towards food, they represent a certain identity for their readers. This paper investigates the nature of the identity that Belgian cookbooks constructed through their rhetoric. An important part of this study is to explore how and to what extent explicit reference to Belgium was made. To this end recipe titles/labels and recipe comments used in two leading bourgeois cookbooks from nineteenth-century Belgium were subjected to a quantitative and qualitative content analysis. The analysis showed that clear attention was paid to national culinary preferences. In terms of a domestic culinary corpus, it became apparent that both the Dutch and French editions of these cookbooks promoted dishes that were ascribed a Belgian origin. Internationality, however, was also an important building block of Belgian culinary identity. It was part of the desire of Belgian bourgeoisie to connect with an international elite. It fit into the 'search for sophistication', which was also expressed through the high representation of the more costly meats and sweet dishes. In addition, other references associated with bourgeois norms and values, such as family, convenience and frugality, were additional building blocks of Belgian culinary identity. Other issues such as tradition, innovation and health, were also matters of concerns to these Belgian cookbooks. Copyright © 2013 Elsevier Ltd. All rights reserved.

  4. Prevalence of hormone replacement therapy in a sample of middle-aged women

    DEFF Research Database (Denmark)

    Pedersen, S H; Jeune, B

    1988-01-01

    A survey based on a postal questionnaire sent to a random sample of Danish women aged 40-59 yr living on the island of Fünen (n = 401, response rate = 79%) revealed that the overall prevalence of the use of hormone replacement therapy (HRT) was 16%, the highest rate being in the 50-54 age group (21......%). Among post-menopausal women the rate was 21% and it was highest of all (37%) in those who had undergone an artificial menopause. The median age at the start of treatment was 44.3 yr among the artificial menopause and 48.9 yr among the natural menopause subjects. About half of the women were treated...

  5. The rate of progression of renal disease may not be slower in women compared with men

    DEFF Research Database (Denmark)

    Jafar, Tazeen H; Schmid, Christopher H; Stark, Paul C

    2003-01-01

    patient characteristics, and changes from baseline to follow-up systolic blood pressure (SBP) and urine protein (UP) excretion. RESULTS: The total number of patients was 1860: 645 (35%) females and 1215 (65%) males. Mean duration of follow-up was 2.2 years. The proportions randomized to ACEI (51%), mean...... ACEIs and baseline UP, and 1.36 (1.06-1.75) after adjusting for baseline variables and changes in SBP and UP during follow-up. Similar results were found for the outcome of ESRD. CONCLUSIONS: Our findings suggest that the rate of renal disease progression may not be slower, and may even be faster...... in women compared with men, after adjusting for other factors associated with a faster rate of progression. We caution that most women in our database were of post-menopausal age, and thus our findings may not extend to younger women....

  6. The radiological impact of the Belgian phosphate industry

    Energy Technology Data Exchange (ETDEWEB)

    Vanmarcke, H.; Paridaens, J. [Belgian Nuclear Research Centre, SCK.CEN, Boeretang 200, 2400 Mol (Belgium)

    2006-07-01

    The Belgian phosphate industry processes huge amounts of phosphate ore (1.5 to 2 Mton/year) for a wide range of applications, the most important being the production of phosphoric acid, fertilizers and cattle food. Marine phosphate ores show high specific activities of the natural uranium decay series (usually indicated by Ra-226) (e.g. 1200 to 1500 Bq/kg for Moroccan ore). Ores of magmatic origin generally contain less of the uranium and more of the thorium decay series (up to 500 Bq/kg). These radionuclides turn up in by-products, residues or product streams depending on the processing method and the acid used for the acidulation of the phosphate rock. Sulfuric acid is the most widely used, but also hydrochloric acid and nitric acid are applied in Belgium. For Flanders, the northern part of Belgium, we already have a clear idea of the production processes and waste streams. The five Flemish phosphate plants, from 1920 to 2000, handled 54 million ton of phosphate ore containing 65 TBq of radium-226 and 2.7 TBq of thorium- 232. The total surface area of the phosphogypsum and calcium fluoride sludge deposits amounts to almost 300 ha. There is also environmental contamination along two small rivers receiving the waste waters of the hydrochloric production process: the Winterbeek (> 200 ha) and the Grote Laak (12 ha). The data on the impact of the phosphate industry in the Walloon provinces in Belgium is less complete. A large plant produced in 2004 0.8 Mton of phosphogypsum, valorizing about 70 % of the gypsum in building materials (plaster, cement), in fertilizers, and in other products such as paper. The remainder was stored on a local disposal site. The radiological impact of the Belgian phosphate industry on the local population will be discussed. At present most contaminated areas are still recognizable as waste deposits and inaccessible to the population. However as gypsum deposits and other contaminated areas quickly blend in with the landscape, it is

  7. Fat-soluble vitamin intake from the consumption of food, fortified food and supplements: design and methods of the Belgian VITADEK study.

    Science.gov (United States)

    Moyersoen, Isabelle; Demarest, Stefaan; De Ridder, Karin; Tafforeau, Jean; Lachat, Carl; Van Camp, John

    2017-01-01

    The adequacy of micronutrient intake is a public health concern, as both insufficient and excessive intake levels may result in adverse health effects. Data on dietary intake are needed to evaluate potential problems regarding inadequate intake at population level and to formulate effective public health and food safety recommendations. Assessing the intake of micronutrients in population subgroups such as infants, toddlers, pregnant and lactating women is challenging and requires specific approaches. This paper describes the Belgian VITADEK study, developed to assess fat-soluble vitamin intake from the consumption of food, fortified foods and supplements in four vulnerable groups namely infants, toddlers, pregnant and lactating women. Subjects were selected according to a multi-stage stratified sampling design with a selection of clusters proportionate to the population size. Recruitment occurred in collaboration with Belgian child health consultation centres and obstetric clinics. Participants were asked to complete a self-administered online food frequency questionnaire (FFQ) or to answer the questionnaire by phone if online participation was not possible. The questionnaire was tailored to the specific diet of the different target populations. In order to capture vitamin intake from the consumption of foods, fortified foods and supplements, a market study was conducted to take an inventory of the fortified foods and supplements available on the Belgian market. The food list of the FFQ was based on both this inventory and the top 90% food groups that contribute to fat-soluble vitamin intake. Since fortification differs at brand level, food groups and subgroups were split up to the level of the brand of foods. Brand pictures were used as mnemonics to facilitate the recall of the consumed food items and portion pictures were used to facilitate the reproduction of the consumed portion sizes. Finally a composition table was compiled allowing for the computation of

  8. Variability of patient safety culture in Belgian acute hospitals.

    Science.gov (United States)

    Vlayen, Annemie; Schrooten, Ward; Wami, Welcome; Aerts, Marc; Barrado, Leandro Garcia; Claes, Neree; Hellings, Johan

    2015-06-01

    The aim of this study was to measure differences in safety culture perceptions within Belgian acute hospitals and to examine variability based on language, work area, staff position, and work experience. The Hospital Survey on Patient Safety Culture was distributed to hospitals participating in the national quality and safety program (2007-2009). Hospitals were invited to participate in a comparative study. Data of 47,136 respondents from 89 acute hospitals were used for quantitative analysis. Percentages of positive response were calculated on 12 dimensions. Generalized estimating equations models were fitted to explore differences in safety culture. Handoffs and transitions, staffing, and management support for patient safety were considered as major problem areas. Dutch-speaking hospitals had higher odds of positive perceptions for most dimensions in comparison with French-speaking hospitals. Safety culture scores were more positive for respondents working in pediatrics, psychiatry, and rehabilitation compared with the emergency department, operating theater, and multiple hospital units. We found an important gap in safety culture perceptions between leaders and assistants within disciplines. Administration and middle management had lower perceptions toward patient safety. Respondents working less than 1 year in the current hospital had more positive safety culture perceptions in comparison with all other respondents. Large comparative databases provide the opportunity to identify distinct high and low scoring groups. In our study, language, work area, and profession were identified as important safety culture predictors. Years of experience in the hospital had only a small effect on safety culture perceptions.

  9. Proba "spacecraft family" small autonomous satellites - a Belgian innovative exportproduct

    Science.gov (United States)

    Bermyn, J.; Du Pre, T.; Bernaerts, Dirk; Baudoux, Dominique

    2004-11-01

    After the successful realisation of Proba 1, a 100 kg small autonomous satellite for ESA technology demonstration purposes now generating for more then 2,5 years splendid earth observation images, and the first steps set in the development of its successor PROBA 2, Verhaert and Spacebel teamed for the further worldwide commercialisation of this innovative Belgian product. In PROBA 1, Verhaert was the prime contractor and acted as the small systems integrator, where Spacebel was responsible for the on-board software development. Verhaert and Spacebel offer now a complete small satellite system solution to the user community. The combined company team deals with the system aspects, while Verhaert is responsible for the satellite platform realisation and the launch procurement. Spacebel realizes the control and exploitation ground segment and is responsible for all data management aspects (on board and ground software). Other elements, such as payload development and operations, are covered by other companies on a case-by-case basis in function of the client's wishes.

  10. Dietary intake of artificial sweeteners by the Belgian population.

    Science.gov (United States)

    Huvaere, Kevin; Vandevijvere, Stefanie; Hasni, Moez; Vinkx, Christine; Van Loco, Joris

    2012-01-01

    This study investigated whether the Belgian population older than 15 years is at risk of exceeding ADI levels for acesulfame-K, saccharin, cyclamate, aspartame and sucralose through an assessment of usual dietary intake of artificial sweeteners and specific consumption of table-top sweeteners. A conservative Tier 2 approach, for which an extensive label survey was performed, showed that mean usual intake was significantly lower than the respective ADIs for all sweeteners. Even consumers with high intakes were not exposed to excessive levels, as relative intakes at the 95th percentile (p95) were 31% for acesulfame-K, 13% for aspartame, 30% for cyclamate, 17% for saccharin, and 16% for sucralose of the respective ADIs. Assessment of intake using a Tier 3 approach was preceded by optimisation and validation of an analytical method based on liquid chromatography with mass spectrometric detection. Concentrations of sweeteners in various food matrices and table-top sweeteners were determined and mean positive concentration values were included in the Tier 3 approach, leading to relative intakes at p95 of 17% for acesulfame-K, 5% for aspartame, 25% for cyclamate, 11% for saccharin, and 7% for sucralose of the corresponding ADIs. The contribution of table-top sweeteners to the total usual intake (sweeteners.

  11. Tai Chi for osteopenic women: design and rationale of a pragmatic randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Fischer Mary

    2010-03-01

    Full Text Available Abstract Background Post-menopausal osteopenic women are at increased risk for skeletal fractures. Current osteopenia treatment guidelines include exercise, however, optimal exercise regimens for attenuating bone mineral density (BMD loss, or for addressing other fracture-related risk factors (e.g. poor balance, decreased muscle strength are not well-defined. Tai Chi is an increasingly popular weight bearing mind-body exercise that has been reported to positively impact BMD dynamics and improve postural control, however, current evidence is inconclusive. This study will determine the effectiveness of Tai Chi in reducing rates of bone turnover in post-menopausal osteopenic women, compared with standard care, and will preliminarily explore biomechanical processes that might inform how Tai Chi impacts BMD and associated fracture risks. Methods/Design A total of 86 post-menopausal women, aged 45-70y, T-score of the hip and/or spine -1.0 and -2.5, have been recruited from primary care clinics of a large healthcare system based in Boston. They have been randomized to a group-based 9-month Tai Chi program plus standard care or to standard care only. A unique aspect of this trial is its pragmatic design, which allows participants randomized to Tai Chi to choose from a pre-screened list of community-based Tai Chi programs. Interviewers masked to participants' treatment group assess outcomes at baseline and 3 and 9 months after randomization. Primary outcomes are serum markers of bone resorption (C-terminal cross linking telopeptide of type I collagen, bone formation (osteocalcin, and BMD of the lumbar spine and proximal femur (dual-energy X-ray absorptiometry. Secondary outcomes include health-related quality-of-life, exercise behavior, and psychological well-being. In addition, kinetic and kinematic characterization of gait, standing, and rising from a chair are assessed in subset of participants (n = 16 to explore the feasibility of modeling skeletal

  12. Relationship of homocysteine levels with lumbar spine and femur neck BMD in postmenopausal women

    Directory of Open Access Journals (Sweden)

    Elton Bahtiri

    2015-10-01

    Full Text Available Objective: The focus of several studies in recent years has been the association between increased plasma concentrations of homocysteine (Hcy, reduced bone mineral density and increased risk of bone fractures. Nevertheless, inconsistencies persist in the literature. Thus, the objective of this study was to investigate the possible relationship between serum Hcy and vitamin B12 status, and bone mineral density, on a group of post-menopausal women. Materials and methods: One hundred thirty-nine postmenopausal women were recruited to enter this cross-sectional study. Bone mineral density (BMD of total hip, femoral neck and lumbar spine was measured by dual-energy X-ray absorptiometry (DXA and serum Hcy, vitamin B12, parathyroid hormone (PTH, total calcium and magnesium levels were determined. In addition, we investigated the relationship of Hcy and vitamin B12 and BMD using a meta-analysis approach. Results: Serum Hcy levels were significantly higher in osteoporotic women when compared to other BMD groups, and were inversely related to lumbar spine BMD and femur neck BMD. Body mass index and serum Hcy levels were shown to be significant predictors of BMD at lumbar spine, femur neck and total hip. The performed meta-analysis showed that serum Hcy levels were significantly higher in osteoporotic subjects compared to normal BMD subjects. Conclusion: This study shows that Hcy status, but not vitamin B12 status, is associated with BMD in this cohort of postmenopausal women. We therefore confirm that high Hcy levels are an independent risk factor for osteoporosis. BMD evaluation in women at post menopause with high Hcy levels may be helpful in advising precautionary measures.

  13. The usefulness of Belgian formulae in third molar-based age assessment of Indians.

    Science.gov (United States)

    Bhowmik, Biyas; Acharya, Ashith B; Naikmasur, Venkatesh G

    2013-03-10

    The third molars are one of few useful predictors for assessing the degree of maturity in adolescence and young adulthood. It has application in age estimation in the age group of 14-23 years, in general, and in juvenile/adult status prediction, in particular. Using a 10-stage grading of third molars, Gunst et al. developed regression formulae on a large sample of Belgians (n=2513) for estimating age. Their research has been recommended as a 'reference study' in age estimation guidelines. The present study has ventured to determine if estimating age in Indians using the Belgian formulae produced results comparable to those reported in the Belgian study; in addition, this study attempts to determine if the same formulae predicted juvenile/adult status (age aged between 14 and 23 years. The OPGs included a mix of one, two, three and four third molars. In total, 916 teeth were assessed using the same 10-stage grading. Age in each OPG was estimated by applying the relevant Belgian regression formulae (regression formulae are available for one, two, three and four third molars). To determine if the formulae produced age estimates comparable to those in the Belgian study, the percentage of Indian subjects whose actual age fell within the 68% confidence interval (CI) (calculated from the ± 1 S.D. value available for each Belgian formula) was ascertained. If ≥ 68% of Indian subjects' age fell inside this interval, it indicates that the Belgian formulae are applicable in Indians. To assess the suitability of the Belgian formulae in predicting juvenile/adult status in Indians, the accuracy of the age estimation per se was not considered, rather, the number of correct age predictions only was noted. Overall, ≈ 74% of Indian subjects' actual age fell within the 68% CI; with regards to the Belgian formulae being able to correctly predict juvenile/adult status, 78% of all subjects were categorized to the correct age group (age estimation per se of Indians; however, the

  14. Endocrine identification of menopausal status of Sudanese women

    International Nuclear Information System (INIS)

    Khalid, M. M. M.

    2010-12-01

    the early peri-menopause with mild signs and symptoms to the late peri-menopausal stage which almost resembles the post-menopause. The new classification system using its three key tools had successfully classified the heterogeneous peri-menopausal stage into three distinct sub-classes with characteristic hormonal and symptomatic manifestation for each. The three subclasses are early peri-menopausal women who are characterized by presence of normal hormonal levels (FSH and LH) but who suffer amenorrhea. FSH level of this subclass although within the normal range, it is higher than that of the preceding class pre-menopausal stage, but the difference is not statistically significant. Therefore, women who suffer irregular cycles and amenorrhea due to other endocrine causes (hyperprolactinaemia, hypo- and hyperthyroidism, etc) can be mis classified as early peri-menopausal. Therefore, the other endocrine causes should be ruled out before including them in this subclass by measurement of respective hormones, namely, prolactin and TSH levels. The second subclass is the med peri-menopausal women who are characterized by elevated FSH levels but unlike the preceding subclass they do not suffer amenorrhea, the reason for this is not clear, but it seems the ovary is still secreting sufficient oestrogen levels to prime the uterus and maintains regular menstrual cycles. However, further research with a larger sample size is needed to clarify this situation. The third subclass is the late peri-menopausal women who are having elevated FSH levels, but normal LH levels and they suffer amenorrhea, indicating the beginning of cessation menstruation. The new classification scheme indicated that LH levels increase sharply immediately after menopause signaling the end of reproductive life and beginning of the post menopausal life. The new classification scheme indicated that early post-menopausal women are those who have elevated FSH and LH, but who experience a menstrual cycle during the

  15. REMOVABLE PARTIAL DENTURE MANAGEMENT ON POST-MENOPAUSE OSTEOPOROTIC FEMALE

    Directory of Open Access Journals (Sweden)

    Nina Ariani

    2015-06-01

    Full Text Available Osteoporosis is a condition of generalised skeletal fragility caused by diminishing bone amount and disturbance in bone microarchitecture with implication that the bone's ability to withstand forces is decreased. This condition leads to more bone resorption. Some researchers show that this condition also affects jaw bone. Therefore we must take this condition into consideration during prothodontic treatment. Dental prostheses are made to restore stomatognatic function as well as to preserve what was left including alveolar bone. The ability of dental prostheses to preserve residual alveolar bone differs according to type of prostheses. The case presented here propose the treatment of osteoporotic female in Prosthodontics Clinic FKG UI with removable partial denture. Considerations in selecting the type and design of dental prostheses and attempts to modify factors that might play a role in bone resorption in connection with the patient's physical and psychological status will be discussed. Thorough examination, careful planning and good communication with the patient can provide optimum results.

  16. Treatment of post-menopausal osteoporosis: beyond bisphosphonates.

    Science.gov (United States)

    Ishtiaq, S; Fogelman, I; Hampson, G

    2015-01-01

    Osteoporosis is a highly prevalent condition, characterized by compromised bone strength and fragility fractures and with an important associated socio-economic burden. Bisphosphonates are well established as the first line treatment for osteoporosis. However, while randomized control trials have in general demonstrated reasonable anti-fracture efficacy at the spine, they have shown moderate reduction in fracture incidence for non-vertebral sites. Furthermore, oral bisphosphonates are commonly associated with adverse gastrointestinal effects and both oral and parenteral bisphosphonates have been linked with osteonecrosis of the jaw and atypical femoral fracture, two rare but debilitating side effects. In addition, bisphosphonates are not recommended in patients with GFR bisphosphonates. Over the past 20 years, knowledge and a deeper understanding of the various signalling pathways involved in bone remodelling has increased, enabling identification of additional targets for therapy. This review focuses on these newer therapies and includes anti-resorptive agents such as raloxifene and other selective oestrogen receptor modulators, the monoclonal antibody denosumab (which inhibits the RANKL pathway), odanacatib, a cathepsin K inhibitor and the anabolic agents, PTH analogue; PTH (1-34) and anti-sclerostin antibodies (activator of the Wnt pathway). Strontium ranelate will not be reviewed as recent reports highlight concerns surrounding its cardiovascular safety and together with an apparent increased risk of thrombosis, its future use remains uncertain. Some of these agents such as raloxifene, denosumab and teriparatide are already in clinical use whilst others are at varying stages of development. This review will provide an overview of the mechanisms of action of these therapeutic agents on the skeleton and assess their efficacy in osteoporosis and fracture prevention.

  17. Impact of grazing on carbon balance of a Belgian grassland

    Science.gov (United States)

    Jérôme, Elisabeth; Beckers, Yves; Bodson, Bernard; Moureaux, Christine; Dumortier, Pierre; Beekkerk van Ruth, Joran; Aubinet, Marc

    2013-04-01

    This work analyzes the impact of grazing on the carbon balance of a grassland grazed by the Belgian Blue breed of cattle. The research was run at the Dorinne terrestrial observatory (DTO). The experimental site is a permanent grassland of ca. 4.2 ha located in the Belgian Condroz (50° 18' 44" N; 4° 58' 07" E; 248 m asl.). Other studies are conducted at the DTO including measurements of methane (CH4) and nitrous oxide fluxes (Dumortier et al., Geophysical Research Abstracts, Vol. 15, EGU2013-2083-1, 2013; Beekkerk van Ruth et al., Geophysical Research Abstracts, Vol. 15, EGU2013-3211, 2013, respectively). Grassland carbon budget (Net Biome Productivity, NBP) was calculated from Net Ecosystem Exchange (NEE) measured by eddy covariance by taking imports and exports of organic C and losses of carbon as CH4 into account. After 2 years of measurements (May 2010 - May 2012), the grassland behaved on average as a CO2 source (NEE = 73 ±31 g C m-2 y-1). After inclusion of all the C inputs and outputs the site was closed to equilibrium (NBP = 23 ±34 g C m-2 y-1). To analyze the impact of grazing on CO2 fluxes, we studied the temporal evolution of gross maximal photosynthetic capacity GPPmax and dark respiration Rd (deduced from the response of daytime fluxes to radiation over 5-day windows). We calculated GPPmax and Rd variation between the end and the beginning of grazing or non-grazing periods (ΔGPPmax and ΔRd, respectively). We observed a significant decrease of GPPmax during grazing periods and measured a ΔGPPmax dependence on the average stocking rate. This allows us to quantify the assimilation reduction due to grass consumption by cattle. On the contrary, no Rd decrease was observed during grazing periods. Moreover, we found that cumulated monthly NEE increased significantly with the average stocking rate. In addition, a confinement experiment was carried out in order to analyze livestock contribution to Total Ecosystem Respiration. Each experiment extended over

  18. Emergence of bovine ehrlichiosis in Belgian cattle herds.

    Science.gov (United States)

    Guyot, Hugues; Ramery, Eve; O'Grady, Luke; Sandersen, Charlotte; Rollin, Frédéric

    2011-06-01

    Bovine ehrlichiosis is a tick-borne rickettsial disease caused by Anaplasma phagocytophilum. The disease can also be transmitted to humans. Outbreaks in cattle have been described in many European countries. In Belgium, infections caused by A. phagocytophilum have been reported in humans and dogs; however, this paper details the first report of ehrlichiosis in cattle herds in Belgium. The first case described was in a dairy herd located in eastern Belgium. Clinical signs included hyperthermia, polypnea, and swelling of the limbs. The other case was diagnosed in a second, mixed purpose herd in western Belgium. Within the second herd, all of the affected animals came from the same pasture. All animals in that pasture showed recurrent hyperthermia, and some also showed signs of mastitis and late-term abortions. Blood smears and serology revealed the presence of A. phagocytophilum in the majority of animals with pyrexia. Furthermore, the presence of leptospirosis, Neospora caninum, and Q fever antibodies was tested by serological analysis, but all results were negative. Paired serology for Adenovirus, BHV-4, BHV-1, BVD, PI3, and RSV-B did not show any significant seroconversion. Milk samples from cows affected by mastitis revealed minor pathogens. Fecal testing for the presence of Dictyocaulus viviparus in the first herd was negative. Recurrent pyrexia in pastured cattle is a non-specific sign, and can be related to several different pathogens. Bovine ehrlichiosis is transmitted by the tick species Ixodes ricinus which is known to be present throughout Belgium. Belgian practitioners should include ehrlichiosis in their differential diagnosis when confronted with pastured cattle suffering from recurrent pyrexia. Copyright © 2011 Elsevier GmbH. All rights reserved.

  19. The mesozooplankton community of the Belgian shelf (North Sea)

    Science.gov (United States)

    Van Ginderdeuren, Karl; Van Hoey, Gert; Vincx, Magda; Hostens, Kris

    2014-01-01

    This manuscript presents the mesozooplankton community structure and its spatial and temporal variabilities in the Belgian part of the North Sea (BPNS), a first thorough study on this topic in nearly 40 years. Monthly sampling campaigns at ten stations in the BPNS in 2009 and 2010 yielded a total of 137 mesozooplankton taxa (46 holoplanktonic, 50 meroplanktonic and 41 tychoplanktonic), of which nine species had never been reported in the area. Smaller neritic copepods, especially Temora longicornis and Acartia clausi, were present in all samples and dominated zooplankton densities (66%), together with the appendicularian Oikopleura dioica (10%). They were joined by high numbers of meroplanktonic echinoderm larvae (9%) in spring and summer. Based on diversity alone, the mesozooplankton could be typified as one neritic zooplankton community, due to the ubiquitous presence in time and space of the dominant copepods. Yet, these neritic species were often joined by low numbers of oceanic species that are occasionally imported with the inflow of Atlantic oceanic water in the BPNS. Based on a combination of abundance and diversity, our results indicate distinct seasonal and spatial distribution patterns in the mesozooplankton. Months with highest average densities were May, June and July, lowest densities were noted in December and January. Only limited long-term zooplankton data are available for the BPNS from the Continuous Plankton Recorder surveys or the long-term monitoring stations in the vicinity of our research area. However, our data suggest that nowadays zooplankton species appear earlier in the BPNS, comparable with other areas in the North Sea. Densities varied between 150 and 15,000 ind.m- 3, and averaged highest at midshore stations, then nearshore and offshore. This is partially comparable with the spatial patterns recorded for other ecosystem components, such as demersal fish, epibenthos and macrobenthos, of which densities peak in a stretch almost

  20. A survey of bacteria found in Belgian dairy farm products

    Directory of Open Access Journals (Sweden)

    N'Guessan, E.

    2015-01-01

    Full Text Available Description of the subject. Due to the potential hazards caused by pathogenic bacteria, farm dairy production remains a challenge from the point of view of food safety. As part of a public program to support farm diversification and short food supply chains, farm dairy product samples including yogurt, ice cream, raw-milk butter and cheese samples were collected from 318 Walloon farm producers between 2006 and 2014. Objectives. Investigation of the microbiological quality of the Belgian dairy products using the guidelines provided by the European food safety standards. Method. The samples were collected within the framework of the self-checking regulation. In accordance with the European Regulation EC 2073/2005, microbiological analyses were performed to detect and count Enterobacteriaceae, Listeria monocytogenes, Salmonella spp., Escherichia coli and Staphylococcus aureus. Results. Even when results met the microbiological safety standards, hygienic indicator microorganisms like E. coli and S. aureus exceeded the defined limits in 35% and 4% of butter and cheese samples, respectively. Unsatisfactory levels observed for soft cheeses remained higher (10% and 2% for S. aureus and L. monocytogenes respectively than those observed for pressed cheeses (3% and 1% and fresh cheeses (3% and 0% (P ≥ 0.05. Furthermore, the percentages of samples outside legal limits were not significantly higher in the summer months than in winter months for all mentioned bacteria. Conclusions. This survey showed that most farm dairy products investigated were microbiologically safe. However, high levels of hygiene indicators (e.g., E. coli in some products, like butter, remind us of applying good hygienic practices at every stage of the dairy production process to ensure consumer safety.

  1. Belgian nuclear forum - launching the public debate on nuclear energy

    International Nuclear Information System (INIS)

    Leclere, Robert; Van Landeghem, Yves

    2010-01-01

    In the past decades, public opinion on nuclear power was dominated by a 'sleeping', indifferent majority. Nothing moved until (a minority of) opponents began to stir. Their activism strongly contrasted with the low-profile attitude of the nuclear players and pushed a considerable part of the indifferent majority towards a more negative attitude. A 2007 opinion poll (IFOP) confirmed this trend. The poll also revealed a major lack of objective and factual information. Incorrect and incomplete arguments tended to demonize nuclear energy, and 'nuclear' became a brand polarizing public opinion. This had a negative impact on decision-makers and culminated in the Belgian phase-out law of 2003. Based on the opinion poll, the members of the Belgian Nuclear Forum decided to launch a public information campaign, which they would jointly finance, with these goals: - In 3 to 4 years time, create greater public awareness on energy matters and move public opinion towards a more positive attitude. - Gain recognition of nuclear energy's legitimate place in the mix, and of the importance of peaceful nuclear applications. - Attract attention to the Belgian know-how and the importance of the industry on the scientific and economical level. - Optimize conditions for important nuclear issues such as long-term operation of NPPs, new nuclear research projects (MYRRHA),.. A 'push-pull' approach was adopted: push communication to the public (campaign) to pull (involve) decision-makers and get nuclear back on the political agenda. The Forum also opted for a sustained, long-term effort based on public campaigning, public relations and public affairs. Considering its long-time absence from the public debate, the Forum and its agency Saatchi and Saatchi agreed upon the following principles to underpin the campaign: - No 'pro-campaign'; that would be highly unrealistic and have a negative effect; - No taboos: bring up both the pros and cons; - No emotions: bring reason into a mainly emotional

  2. Importance of physical examination in early detection of lump in breast in women of different age groups.

    Science.gov (United States)

    Abbas, Hafsa; Imran, Saira; Waris, Noorul-ain-Hafeez; Khanam, Andleeb; Khurshid, Rukshshan

    2010-01-01

    The spectrum of breast lesions in adolescents varies markedly from that for adults, with the former lesions being overwhelmingly benign. Fine needle biopsy can be used to distinguish benign and malignant tumour. This study examined the characteristics and outcome of women with different age groups in whom physical examination was their sole method of lump in breast detection. A total of 200 patients were included in the study. These were divided into 3 groups. Group A was consisting of 75 girls with age of pubescent. Group B included 69 suspected breast cancer women with age range 26-38 years. Fifty-six suspected breast cancer women with age range 41-60 year were included as group C. Study was carried out in patients admitted in the Department/Out-door of Surgery, Sir Ganga Ram Hospital, Lahore, Pakistan. Study period was 6 months. All women received a physical examination by a breast surgeon. Proforma including demographic and clinical characteristics were filled. The diagnosis for patients in this study was achieved by core needle biopsy using a 14-gauge cutting needle. It was observed that early age at menarche (25 may be a risk factor in peri/post menopausal women. Active life style is more important with increasing age as it decreases the risk of developing tumour state. Family history was more common in women with peri/post menopausal status as compared to other age groups. Clinical characteristics showed that lump size early detection or clinical examination with FNA cut out the patients from harassment of malignancy and complications especially in the pubescent age. It is also found that Physical examination remain the useful indicators of prognosis in diagnosing cancer. Further research is needed to fully understand the reasons for variations in breast disease outcomes i.e. malignant or benign.

  3. Hypnosis for hot flashes among postmenopausal women study: A study protocol of an ongoing randomized clinical trial

    Directory of Open Access Journals (Sweden)

    Johnson Aimee K

    2011-10-01

    Full Text Available Abstract Background Hot flashes are a highly prevalent problem associated with menopause and breast cancer treatments. The recent findings from the Women's Health Initiative have important implications for the significance of a non-hormonal, mind-body intervention for hot flashes in breast cancer survivors. Women who take hormone therapy long-term may have a 1.2 to 2.0 fold increased risk of developing breast cancer. In addition, it is now known that hormone therapy with estrogen and progestin is associated with increased risk of cardiovascular disease and stroke. Currently there are limited options to hormone replacement therapy as non-hormonal pharmacological agents are associated with only modest activity and many adverse side effects. Because of this there is a need for more alternative, non-hormonal therapies. Hypnosis is a mind-body intervention that has been shown to reduce self-reported hot flashes by up to 68% among breast cancer survivors, however, the use of hypnosis for hot flashes among post-menopausal women has not been adequately explored and the efficacy of hypnosis in reducing physiologically measured hot flashes has not yet been determined. Methods/design A sample of 180 post-menopausal women will be randomly assigned to either a 5-session Hypnosis Intervention or 5-session structured-attention control with 12 week follow-up. The present study will compare hypnosis to a structured-attention control in reducing hot flashes (perceived and physiologically monitored in post-menopausal women in a randomized clinical trial. Outcomes will be hot flashes (self-report daily diaries; physiological monitoring; Hot Flash Related Daily Interference Scale, anxiety (State-Trait Anxiety Inventory; Hospital Anxiety and Depression Scale (HADS; anxiety visual analog scale (VAS rating; depression (Center for Epidemiologic Studies Depression Scale, sexual functioning (Sexual Activity Questionnaire, sleep quality (Pittsburgh Sleep Quality Index and

  4. Healthy lifestyle and decreasing risk of heart failure in women: the Women's Health Initiative observational study.

    Science.gov (United States)

    Agha, Golareh; Loucks, Eric B; Tinker, Lesley F; Waring, Molly E; Michaud, Dominique S; Foraker, Randi E; Li, Wenjun; Martin, Lisa W; Greenland, Philip; Manson, JoAnn E; Eaton, Charles B

    2014-10-28

    The impact of a healthy lifestyle on risk of heart failure (HF) is not well known. The objectives of this study were to evaluate the effect of a combination of lifestyle factors on incident HF and to further investigate whether weighting each lifestyle factor has additional impact. Participants were 84,537 post-menopausal women from the WHI (Women's Health Initiative) observational study, free of self-reported HF at baseline. A healthy lifestyle score (HL score) was created wherein women received 1 point for each healthy criterion met: high-scoring Alternative Healthy Eating Index, physically active, healthy body mass index, and currently not smoking. A weighted score (wHL score) was also created in which each lifestyle factor was weighted according to its independent magnitude of effect on HF. The incidence of hospitalized HF was determined by trained adjudicators using standardized methodology. There were 1,826 HF cases over a mean follow-up of 11 years. HL score was strongly associated with risk of HF (multivariable-adjusted hazard ratio [HR] [95% confidence interval (CI)] 0.49 [95% CI: 0.38 to 0.62], 0.36 [95% CI: 0.28 to 0.46], 0.24 [95% CI: 0.19 to 0.31], and 0.23 [95% CI: 0.17 to 0.30] for HL score of 1, 2, 3, and 4 vs. 0, respectively). The HL score and wHL score were similarly associated with HF risk (HR: 0.46 [95% CI: 0.41 to 0.52] for HL score; HR: 0.48 [95% CI: 0.42 to 0.55] for wHL score, comparing the highest tertile to the lowest). The HL score was also strongly associated with HF risk among women without antecedent coronary heart disease, diabetes, or hypertension. An increasingly healthy lifestyle was associated with decreasing HF risk among post-menopausal women, even in the absence of antecedent coronary heart disease, hypertension, and diabetes. Weighting the lifestyle factors had minimal impact. Copyright © 2014 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

  5. Regional osteoporosis in western Sydney women

    International Nuclear Information System (INIS)

    Larcos, G.; Lawson-Smith, R.

    1998-01-01

    Full text: Recently, 15% of elderly Japanese-American women have been shown to have marked heterogeneity of bone mineral density (BMD) between measured sites. The purposes of this study were to determine (1 ) the prevalence of this finding in an Australian population; and (2) potential association with clinical factors such as age, years since menopause (YSM), alcohol, smoking, family history, exercise, and body mass index. One hundred and fourteen peri-or post- menopausal Caucasian women (mean age 55 + 8.8 years) were referred for osteoporotic (OP) fracture risk assessment. Patients (pts) had no disorders or drugs known to affect BMD and no evidence of scoliosis or arthritic change. Bone densitometry of the lumbar spine (PA), hip and distal radius were measured using a Norland XR-26. According to WHO criteria, 30 pts (26%) were normal (T score > -1) at all sites; no pts (0%) had generalised OP (T score < -2.5); 29 (25%) had OP in one or two sites only (hip = 25, spine = 13, wrist = 1); the remaining 55 pts (48%) were osteogenic (-2.5 < T score < -1) in at least one site. Using multivariate logistic regression analysis, only YSM predicted regional OP (odds ratio = 1.14; p< O.001) Thus, clinically important heterogeneity of BMD occurs in about 25% of Western Sydney women; of clinical factors only YSM is independently associated with regional OP. Fracture risk classification may be improved by BMD measurement of multiple sites

  6. Attitude of a group of Belgian stakeholders towards proposed agricultural countermeasures after a radioactive contamination: synthesis of the discussions within the Belgian EC-FARMING group

    Energy Technology Data Exchange (ETDEWEB)

    Vandecasteele, C.M. [FANC, Ravenstein Street 36, B-1000 Brussels (Belgium)]. E-mail: christian.vandecasteele@fanc.fgov.be; Hardeman, F. [SCK.CEN, Boeretang 200, B-2400 Mol (Belgium); Pauwels, O. [CGCCR, rue Ducale, B-1000 Brussels (Belgium); Bernaerts, M. [CGCCR, rue Ducale, B-1000 Brussels (Belgium); Carle, B. [SCK.CEN, Boeretang 200, B-2400 Mol (Belgium); Sombre, L. [FANC, Ravenstein Street 36, B-1000 Brussels (Belgium)

    2005-07-01

    In the case of radioactive contamination of the environment with an impact on the food chain, the remediation strategy will not only be based on scientific knowledge and technical experience, but will also be dictated by peculiarities of the country. These characteristics include the agro-industrial structure, the local and international economical contexts and the political configuration including the distribution of responsibilities and competencies. This paper identifies and illustrates the most relevant characteristics of the Belgian agricultural system and political environment; it also describes the past experience with food chain contamination, which is expected to influence the attitude of Belgian stakeholders, who would be involved in the setting up of countermeasure strategies for maintaining agricultural production and food safety. The picture drawn explains why several countermeasures aiming to reduce the contamination in food products, although scientifically sound and technically feasible, are hardly acceptable or even not acceptable at all, to the stakeholders.

  7. Attitude of a group of Belgian stakeholders towards proposed agricultural countermeasures after a radioactive contamination: synthesis of the discussions within the Belgian EC-FARMING group

    International Nuclear Information System (INIS)

    Vandecasteele, C.M.; Hardeman, F.; Pauwels, O.; Bernaerts, M.; Carle, B.; Sombre, L.

    2005-01-01

    In the case of radioactive contamination of the environment with an impact on the food chain, the remediation strategy will not only be based on scientific knowledge and technical experience, but will also be dictated by peculiarities of the country. These characteristics include the agro-industrial structure, the local and international economical contexts and the political configuration including the distribution of responsibilities and competencies. This paper identifies and illustrates the most relevant characteristics of the Belgian agricultural system and political environment; it also describes the past experience with food chain contamination, which is expected to influence the attitude of Belgian stakeholders, who would be involved in the setting up of countermeasure strategies for maintaining agricultural production and food safety. The picture drawn explains why several countermeasures aiming to reduce the contamination in food products, although scientifically sound and technically feasible, are hardly acceptable or even not acceptable at all, to the stakeholders

  8. Belgian nuclear forum - launching the public debate on nuclear energy

    Energy Technology Data Exchange (ETDEWEB)

    Leclere, Robert [Belgian Nuclear Forum, Gulledelle, 1200 Brussels (Belgium); Van Landeghem, Yves [Saatchi and Saatchi Belgium, Avenue Rogier, 1030 Brussels (Belgium)

    2010-07-01

    In the past decades, public opinion on nuclear power was dominated by a 'sleeping', indifferent majority. Nothing moved until (a minority of) opponents began to stir. Their activism strongly contrasted with the low-profile attitude of the nuclear players and pushed a considerable part of the indifferent majority towards a more negative attitude. A 2007 opinion poll (IFOP) confirmed this trend. The poll also revealed a major lack of objective and factual information. Incorrect and incomplete arguments tended to demonize nuclear energy, and 'nuclear' became a brand polarizing public opinion. This had a negative impact on decision-makers and culminated in the Belgian phase-out law of 2003. Based on the opinion poll, the members of the Belgian Nuclear Forum decided to launch a public information campaign, which they would jointly finance, with these goals: - In 3 to 4 years time, create greater public awareness on energy matters and move public opinion towards a more positive attitude. - Gain recognition of nuclear energy's legitimate place in the mix, and of the importance of peaceful nuclear applications. - Attract attention to the Belgian know-how and the importance of the industry on the scientific and economical level. - Optimize conditions for important nuclear issues such as long-term operation of NPPs, new nuclear research projects (MYRRHA),.. A 'push-pull' approach was adopted: push communication to the public (campaign) to pull (involve) decision-makers and get nuclear back on the political agenda. The Forum also opted for a sustained, long-term effort based on public campaigning, public relations and public affairs. Considering its long-time absence from the public debate, the Forum and its agency Saatchi and Saatchi agreed upon the following principles to underpin the campaign: - No 'pro-campaign'; that would be highly unrealistic and have a negative effect; - No taboos: bring up both the pros and cons; - No

  9. Antibiotic use and resistance in animals: Belgian initiatives.

    Science.gov (United States)

    Daeseleire, Els; De Graef, Evelyne; Rasschaert, Geertrui; De Mulder, Thijs; Van den Meersche, Tina; Van Coillie, Els; Dewulf, Jeroen; Heyndrickx, Marc

    2016-05-01

    The widespread use of antibiotics in animals is causing concerns about the growing risk for development and the spread of antibiotic-resistant bacteria. Antibiotic consumption is higher in animals than in humans as reported in a joint publication of EFSA (European Food Safety Agency), ECDC (European Centre for Disease Prevention and Control), and EMA (European Medicines Agency) using data from 2011 and 2012. Both in humans and animals, positive associations between the consumption of antibiotics and resistant bacteria are observed. Responsible use of antibiotics in humans and animals should therefore be promoted. In this paper some general aspects of antibiotic resistance such as microbiological versus clinical resistance, intrinsic versus acquired resistance, resistance mechanisms, and transfer of resistance are briefly introduced. In 2012, the Belgian Center of Expertise on Antimicrobial Consumption and Resistance in Animals (AMCRA) was founded. Its mission is to collect and analyze all data related to antibiotic use and resistance in animals in Belgium and to communicate these findings in a neutral and objective manner. One of AMCRA's 10 objectives is a 50% reduction in antibiotic consumption in veterinary medicine in Belgium by 2020. The aim of this paper is to report on the achievements of this national project. The Institute for Agricultural and Fisheries Research (ILVO, Merelbeke-Melle), in collaboration with Ghent University, is currently working on three nationally funded projects on antibiotic resistance in animal husbandry. In the first project, an in vitro model is used to study the influence of low antibiotic concentrations due to carry-over after production and usage of medicated feed on the development of resistance in the pig gut. Part of that project is to develop a quantitative risk assessment model. A second project focuses on tracking excreted antibiotics used in pig rearing and their influence on the development of antibiotic resistance in pig

  10. Aromatase inhibitors, efficacy and metabolic risk in the treatment of postmenopausal women with early breast cancer

    Directory of Open Access Journals (Sweden)

    Stefano Gonnelli

    2008-12-01

    Full Text Available Stefano Gonnelli1, Roberto Petrioli21Department of Internal Medicine, Endocrine-Metabolic Science and Biochemistry, University of Siena, Italy (Dir. R. Nuti.; 2Department of Human Pathology and Oncology, Medical Oncology Section, University of Siena, Italy (Dir. G. FranciniAbstract: The third-generation aromatase inhibitors (AIs, letrozole, anastrozole and exemestane, are becoming the first choice endocrine drugs for post-menopausal women with breast cancer, since they present greater efficacy when compared with tamoxifen in both adjuvant and metastatic setting. In particular, several large and well designed trials have suggested an important role for AIs in the adjuvant treatment of postmenopausal women with estrogen-receptor positive breast cancer either in the upfront, sequential or extended adjuvant mode. Overall, AIs are associated with a small but significant improvement in disease free survival. The expanding use of AIs in the treatment of early breast cancer means that individual patients will be exposed to the agents for longer durations, making it increasingly important to establish their long-term safety. This review focused on the effects of AIs on bone metabolism, serum lipids and cardiovascular risk. AIs have adverse effects on bone turnover with a reduction of bone mineral density and an increase in the rate of fragility fractures. With respect to tamoxifen AIs present lower thrombotic risk and a less favorable impact on lipid profile, whereas the true effects on cardiovascular risk still remain to be clarified. An adequate monitoring of bone mineral density (BMD and lipid profile could be recommended for post-menopausal women candidate to AIs.Keywords: breast cancer, aromatase inhibitors, bone loss, lipids, cardiovascular risk

  11. Correlation between Reproductive Hormonal Level and Osteoporosis among Women in Mongolia

    Directory of Open Access Journals (Sweden)

    Unentsatsral Lkhagvasuren

    2016-05-01

    Results: The mean menopausal age was 48.4±3.4, which is comparable to the Mongolian population mean menopausal age. The mean serum estradiol level in the normal BMD group was 18.3±13.1 pg/ml and  15.8±10.7 pg/ml in the osteoporotic group. The mean serum FSH in the normal BMD group was 54.5±44.1 pg/ml and 81.3±34.2 pg/ml in the osteoporotic group. The mean serum LH level in the normal BMD group was 53.1±41.2 and 75.1±26.1 pg/ml in the osteoporotic group. The mean T and Z score were lower in the osteoporotic group. FSH and LH levels significantly differed across menopause stages in that those who were post-menopausal had higher levels compared to those who were pre- or peri-menopausal. Both hormones, FSH and LH, showed weak negative correlations with BMD level, but not E2. There were significant negative correlations between FSH and Speed of Sound (SOS (r=-0.16; p<0.01, and  between osteoporosis with age (r=-0.30, p<0.05 and number of childbirths (r=-0.14 p<0.05. Discussion: Osteoporosis is a significant problem with associations to hormone levels in post-menopausal women. In our study, mean serum estradiol levels decreased with age, and the mean FSH and LH levels were higher in women of later menopausal stage. Further study is warranted to investigate the bone related studies to establish better statistical references among Mongolian women.

  12. The labelling and reporting of euthanasia by Belgian physicians: a study of hypothetical cases

    NARCIS (Netherlands)

    Smets, T.; Cohen, J.; Bilsen, J.; van Wesemael, Y.; Rurup, M.L.; Deliens, L.

    2012-01-01

    Background: Belgium legalized euthanasia in 2002. Physicians must report each euthanasia case to the Federal Control and Evaluation Committee. This study examines which end-of-life decisions (ELDs) Belgian physicians label 'euthanasia', which ELDs they think should be reported and the physician

  13. Draft Genome Sequence of Taylorella equigenitalis Strain MCE529, Isolated from a Belgian Warmblood Horse

    OpenAIRE

    Hébert, Laurent; Touzain, Fabrice; de Boisséson, Claire; Breuil, Marie-France; Duquesne, Fabien; Laugier, Claire; Blanchard, Yannick; Petry, Sandrine

    2014-01-01

    Taylorella equigenitalis is the causative agent of contagious equine metritis (CEM), a sexually transmitted infection of horses. We herein report the genome sequence of T. equigenitalis strain MCE529, isolated in 2009 from the urethral fossa of a 15-year-old Belgian Warmblood horse in France.

  14. Draft Genome Sequence of Taylorella equigenitalis Strain MCE529, Isolated from a Belgian Warmblood Horse.

    Science.gov (United States)

    Hébert, Laurent; Touzain, Fabrice; de Boisséson, Claire; Breuil, Marie-France; Duquesne, Fabien; Laugier, Claire; Blanchard, Yannick; Petry, Sandrine

    2014-11-26

    Taylorella equigenitalis is the causative agent of contagious equine metritis (CEM), a sexually transmitted infection of horses. We herein report the genome sequence of T. equigenitalis strain MCE529, isolated in 2009 from the urethral fossa of a 15-year-old Belgian Warmblood horse in France. Copyright © 2014 Hébert et al.

  15. Irradiation-assisted stress corrosion cracking[1997 Scientific Report of the Belgian Nuclear Research Centre

    Energy Technology Data Exchange (ETDEWEB)

    Moons, F.

    1998-07-01

    The programme on corrosion at the Belgian Nuclear Research Centre SCK-CEN started in 1996 and focusses on modelling irradiation-assisted stress corrosion cracking and on developing in-pile electrochemical sensors and diagnostic equipment. The objective of this programme is to predict the behaviour of LWR core internals with respect to IASCC. Progress for 1997 is summarised.

  16. Late onset of Strongyloides stercoralis meningitis in a retired Belgian miner.

    Science.gov (United States)

    Pypen, Y; Oris, E; Meeuwissen, J; Vander Laenen, M; Van Gompel, F; Coppens, G

    2015-12-01

    We report a rare case of Strongyloides stercoralis meningitis in an immunocompromised patient treated for a lung carcinoma. Despite his Belgian origin, he was infected with S. stercoralis due to his former work as a miner. Although mostly prevalent in (sub)tropical areas, there are temperate regions where this nematode can occur.

  17. A Belgian margarine manufacturer is testing the green cogeneration; Un margarinier belge experimente la cogeneration verte

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2006-01-15

    Aigremont, an independent Belgian margarine manufacturer, is exploiting a 'green cogeneration' unit fueled with vegetal and animal fats. This unit generates 770 kW electrical power which is injected into the power grid and the same quantity of thermal power which is consumed by the fabrication process. Short paper. (J.S.)

  18. The Use of English as Ad Hoc Institutional Standard in the Belgian Asylum Interview

    Science.gov (United States)

    Maryns, Katrijn

    2017-01-01

    In institutional settings of globalization, labelled languages are generally preferred over multilingual repertoires and mobile language resources. Drawing on linguistic-ethnographic analysis of the way English is treated as an invariable "ad hoc" idiom in the Belgian asylum interview, this article demonstrates how institutional measures…

  19. Can metacognition compensate for intelligence in the first year of Belgian higher education?

    NARCIS (Netherlands)

    Minnaert, A

    1996-01-01

    This study reports on the effects of metacognitive knowledge and skills compensating for intelligence in relation to academic performance in the first year of Belgian higher education. About 600 freshmen of educational sciences, medicine and psychology participated in this project. Tasks and

  20. Comparing Compositional Effects in Two Education Systems: The Case of the Belgian Communities

    Science.gov (United States)

    Danhier, Julien; Martin, Émilie

    2014-01-01

    The Belgian educational field includes separate educational systems reflecting the division of the country into linguistic communities. Even if the French-speaking and the Dutch-speaking communities keep sharing important similarities in terms of funding rules and structures, they present a huge gap between their respective pupils' achievement.…

  1. Where is the Frame? : Victims and Intruders in the Belgian Press Coverage of the Asylum Issue

    NARCIS (Netherlands)

    Gorp, B. van

    2005-01-01

    In this article an empirically oriented conceptualization of frames is developed, using the issue of asylum and illegal immigration in the Belgian press as a test case. The methodological focus of this study is on the question of how these frames can be detected in the coverage. How can they be

  2. Estimation of price-cost margins and union bargaining power for Belgian manufacturing

    NARCIS (Netherlands)

    Dobbelaere, S.

    2004-01-01

    This paper extends Hall's (1988) [Hall, R.E., 1988. The relationship between price and marginal cost in US industry, Journal of Political Economy, 96, 921-947] methodology to analyze imperfections in both the product and the labor market for firms in the Belgian manufacturing industry over the

  3. Clonal expansion of the Belgian Phytophthora ramorum populations based on new microsatellite markers

    Science.gov (United States)

    A. Vercauteren; I. De Dobbelaere; N. J. Grünwald; P. Bonants; E. Van Bockstaele; M. Maes; K. Heungens

    2010-01-01

    Co-existence of both mating types A1 and A2 within the EU1 lineage of Phytophthora ramorum has only been observed in Belgium, which begs the question whether sexual reproduction is occurring. A collection of 411 Belgian P. ramorum isolates was established during a 7-year survey. Our main objectives were genetic characterization of this population to test for sexual...

  4. Cultural Differences in Complex Addition: Efficient Chinese versus Adaptive Belgians and Canadians

    Science.gov (United States)

    Imbo, Ineke; LeFevre, Jo-Anne

    2009-01-01

    In the present study, the authors tested the effects of working-memory load on math problem solving in 3 different cultures: Flemish-speaking Belgians, English-speaking Canadians, and Chinese-speaking Chinese currently living in Canada. Participants solved complex addition problems (e.g., 58 + 76) in no-load and working-memory load conditions, in…

  5. Avoiding Compliance and Resistance through Collaboration? A Belgian Teaching Portfolio Case

    Science.gov (United States)

    Wouters, Pascale; Clement, Mieke; Frenay, Mariane; Buelens, Herman; Gilis, Annelies

    2014-01-01

    In this paper, the authors describe the implementation process of a teaching portfolio at a Belgian university. The case is intriguing because it departs substantially from what others have described as the typical antagonistic way in which academic developers interact with formal leaders. Rather than being caught in an edgy game of compliance and…

  6. Proceedings of the 9th Dutch-Belgian Information Retrieval Workshop

    NARCIS (Netherlands)

    Aly, Robin; Hauff, C.; den Hamer, Ida; Hiemstra, Djoerd; Huibers, Theo W.C.; de Jong, Franciska M.G.

    Welcome to the 9th Dutch-Belgian Information Retrieval Workshop (DIR). I very well remember the DIR workshop in 2001 that was also organized in Twente. It took place exactly one day before my PhD defense, to give us the opportunity to have one of the PhD committee members, Stephen Robertson, as the

  7. Treatment of chronic generalized periodontitis at women in the period of postmenopause

    Directory of Open Access Journals (Sweden)

    Ostrovskaya L.U.

    2015-03-01

    Full Text Available Purpose: an assessment of efficiency of complex treatment of periodontitis at women in a period of postmenopause with the use of zoledronic acid. Material and methods. Examination and treatment of 90 patients with a chronic generalized periodontitis against post-menopausal osteoporosis has been conducted. Material is processed statistically. Results. Application of preparations of zoledronic acid in complex treatment of system osteoporosis and periodontitis allows to reduce the frequency of recurrence of periodontal disease and to improve indicators of bone remodeling. Conclusion. In conclusion it is worth while determining that zoledronic acid in complex therapy of periodontitis is an effective method of drug correction of a mineral exchange before periodontological surgery.

  8. Development of clinical pharmacy in Belgian hospitals through pilot projects funded by the government.

    Science.gov (United States)

    Somers, A; Spinewine, A; Spriet, I; Steurbaut, S; Tulkens, P; Hecq, J D; Willems, L; Robays, H; Dhoore, M; Yaras, H; Vanden Bremt, I; Haelterman, M

    2018-04-30

    Objectives The goal is to develop clinical pharmacy in the Belgian hospitals to improve drug efficacy and to reduce drug-related problems. Methods From 2007 to 2014, financial support was provided by the Belgian federal government for the development of clinical pharmacy in Belgian hospitals. This project was guided by a national Advisory Working Group. Each funded hospital was obliged to describe yearly its clinical pharmacy activities. Results In 2007, 20 pharmacists were funded in 28 pilot hospitals; this number was doubled in 2009 to 40 pharmacists over 54 institutions, representing more than half of all acute Belgian hospitals. Most projects (72%) considered patient-related activities, whereas some projects (28%) had a hospital-wide approach. The projects targeted patients at admission (30%), during hospital stay (52%) or at discharge (18%). During hospital stay, actions were mainly focused on geriatric patients (20%), surgical patients (15%), and oncology patients (9%). Experiences, methods, and tools were shared during meetings and workshops. Structure, process, and outcome indicators were reported and strengths, weaknesses, opportunities, and threats were described. The yearly reports revealed that the hospital board was engaged in the project in 87% of the cases, and developed a vision on clinical pharmacy in 75% of the hospitals. In 2014, the pilot phase was replaced by structural financing for clinical pharmacy in all acute Belgian hospitals. Conclusion The pilot projects in clinical pharmacy funded by the federal government provided a unique opportunity to launch clinical pharmacy activities on a broad scale in Belgium. The results of the pilot projects showed clear implementation through case reports, time registrations, and indicators. Tools for clinical pharmacy activities were developed to overcome identified barriers. The engagement of hospital boards and the results of clinical pharmacy activities persuaded the government to start structural

  9. The Women's Health Questionnaire (WHQ: Frequently Asked Questions (FAQ

    Directory of Open Access Journals (Sweden)

    Hunter Myra S

    2003-09-01

    Full Text Available Abstract The Women's Health Questionnaire (WHQ is a measure of mid-aged women's emotional and physical health. Since its publication in 1992 the WHQ has been widely used in multinational clinical trials, in epidemiological studies as well as in the evaluation of non-medical treatments. In particular the WHQ has been included as a quality of life measure in trials of hormonal preparations for peri and post menopausal women and in studies using a variety of preventative interventions for mid-aged and older women. The questionnaire was developed in English and standardised on a sample of women aged 45–65 years. It is reliable, has good concurrent validity and is sensitive to detecting change, and is available in 27 languages. The range of subscales included in the WHQ enable a detailed assessment of dimensions of emotional and physical health, such as depression, anxiety, sleep problems, somatic symptoms, with optional subscales for menstrual problems and sexual difficulties. The WHQ is the first measure to be included in the MAPI Research Institute's database, the International Health-related Quality of Life Outcomes Database (IQOD. Drawing upon data from international studies this project aims to produce reference values for cross-culturally valid, reliable and responsive quality of life instruments. In addition to this work, a revised shorter version of the WHQ is currently being developed.

  10. Insulin Resistance Is Associated with Prevalence of Physician-Diagnosed Urinary Incontinence in Postmenopausal Non-Diabetic Adult Women: Data from the Fourth Korea National Health and Nutrition Examination Survey.

    Directory of Open Access Journals (Sweden)

    Byung Il Yoon

    Full Text Available To investigate the association between insulin resistance (IR and urinary incontinence in Korean adult women by analyzing the data from the Korea National Health and Nutrition Examination Survey IV (KNHANES 2007-2009.A nationally representative sample of 5318 non-diabetic Korean women ≥19-years-of-age (3043 premenopausal and 2275 postmenopausal women was included from KNHANES 2008-2010. IR was measured using the homeostasis model assessment of IR (HOMA-IR. Participants in the highest and lowest quartile of HOMA-IR were defined as insulin-resistant and insulin-sensitive respectively. Women who have current physician-diagnosed urinary incontinence were classified as having urinary incontinence.Incontinence was found in 9.18% of the total population, 8.51% of the premenopausal population, and 10.86% of the postmenopausal population. The prevalence of incontinence increased with age, reaching a peak at 60-69-years-of-age. The prevalence of urinary incontinence increased significantly with higher HOMA-IR quartiles in pre- and post-menopausal women (p for linear association = 0.0458 and 0.0009 respectively. Among post-menopausal women, those in the highest quartile of HOMA-IR were significantly more likely to have urinary incontinence compared to those in the lowest quartile [adjusted odds ratio, 1.72; 95% confidence interval, 1.07-2.77]. However premenopausal population exhibited no association between incontinence and HOMA-IR quartiles.Our results suggest that the prevalence of incontinence increased across HOMA-IR in non-diabetic adult women, and especially, IR might be a risk factor for incontinence in postmenopausal non-diabetic women.

  11. Cost-effectiveness of a 21-gene recurrence score assay versus Canadian clinical practice in women with early-stage estrogen- or progesterone-receptor-positive, axillary lymph-node negative breast cancer

    International Nuclear Information System (INIS)

    Hannouf, Malek B; Xie, Bin; Brackstone, Muriel; Zaric, Gregory S

    2012-01-01

    A 21-gene recurrence score (RS) assay may inform adjuvant systematic treatment decisions in women with early stage breast cancer. We sought to investigate the cost effectiveness of using the RS-assay versus current clinical practice (CCP) in women with early-stage estrogen- or progesterone-receptor-positive, axilliary lymph-node negative breast cancer (ER+/ PR + LN- ESBC) from the perspective of the Canadian public healthcare system. We developed a Markov model to project the lifetime clinical and economic consequences of ESBC. We evaluated adjuvant therapy separately in post- and pre-menopausal women with ER+/ PR + LN- ESBC. We assumed that the RS-assay would reclassify pre- and post-menopausal women among risk levels (low, intermediate and high) and guide adjuvant systematic treatment decisions. The model was parameterized using 7 year follow up data from the Manitoba Cancer Registry, cost data from Manitoba administrative databases, and secondary sources. Costs are presented in 2010 CAD. Future costs and benefits were discounted at 5%. The RS-assay compared to CCP generated cost-savings in pre-menopausal women and had an ICER of $60,000 per QALY gained in post-menopausal women. The cost effectiveness was most sensitive to the proportion of women classified as intermediate risk by the RS-assay who receive adjuvant chemotherapy and the risk of relapse in the RS-assay model. The RS-assay is likely to be cost effective in the Canadian healthcare system and should be considered for adoption in women with ER+/ PR + LN- ESBC. However, ongoing assessment and validation of the assay in real-world clinical practice is warranted

  12. [Joséphine Schouteden-Wéry on the Belgian coast: a biologist involved in field work and collection building].

    Science.gov (United States)

    Heizer, Alda; Cerqueira, Aline Cardoso

    2014-01-01

    This text presents the findings and other aspects about the fieldwork of biologist Joséphine Schouteden-Wéry on the coast of Belgium. The information is taken from an article published in 1911 in Recueil de L'Institut Botanique Léo Errera, a periodical of the University of Brussels. Schouteden-Wéry replied to the Royal Society for Medical and Natural Sciences of Brussels (Société Royale des Sciences Médicales et Naturelles de Bruxelles) about the geological, climatic, hydrological and other factors that regulate the geographical distribution of species. She took part in study trips to the Congo, a Belgian colony in Africa, and was a leading member of the Union of Colonial Women (L'Union des Femmes Coloniales).

  13. Total reflection X-ray fluorescence analysis of oral fluids of women affected by osteoporosis and osteopenia

    International Nuclear Information System (INIS)

    Sanchez, Hector Jorge; Valentinuzzi, Maria Cecilia; Grenon, Miram; Abraham, Jose

    2008-01-01

    Osteoporosis is a disease characterized by low bone mass and microarchitectural deterioration of bone tissue, leading to bone fragility and an increased susceptibility to fractures; the early stage of decreased bone density is called osteopenia. More than 200 million people are affected and about 50% of post-menopausic women are expected to develop the disease. Osteoporosis, osteopenia and periodontal disease have in common several risk factors, being hyperthyroidism and smoking habits the most important ones. There is scarce information in the literature about the association between periodontal disease and osteoporosis and/or osteopenia. Some works suggest that osteoporotic women are susceptible to a higher loss of periodontal insertion, alveolar bones, and teeth. Thirty adult post-menopausic women were studied; some of them were healthy (control group) and the rest of them were undergoing some stage of osteoporosis or osteopenia. All the subjects were healthy, non-smokers, not having dental implants, and with communitarian periodontal index higher than 1(CPI > 1). Samples of saliva and gingival crevice fluid were extracted with calibrated micro-capillaries and deposited on Si reflectors. Known amounts of Ga were added to the samples in order to act as internal standard for quantification by the total reflection x-ray fluorescence technique. Experimental concentrations of several elements (P, S, Cl, K, Ca, Cr, Fe, NI, Cu, and Zn) were determined. The concentration of some elements in saliva showed different behavior as compared to gingival crevice fluid. Some critical elements of bone composition, such as Ca and Zn, present very distinguishable behavior. Improvements in the statistics are required for a better assessment of a routine method and to establish some correlation with periodontal disease. TXRF seems to be a promising method to evaluate the evolution of osteoporosis

  14. Total reflection X-ray fluorescence analysis of oral fluids of women affected by osteoporosis and osteopenia

    Science.gov (United States)

    Sánchez, Héctor Jorge; Valentinuzzi, María Cecilia; Grenón, Miram; Abraham, José

    2008-12-01

    Osteoporosis is a disease characterized by low bone mass and microarchitectural deterioration of bone tissue, leading to bone fragility and an increased susceptibility to fractures; the early stage of decreased bone density is called osteopenia. More than 200 million people are affected and about 50% of post-menopausic women are expected to develop the disease. Osteoporosis, osteopenia and periodontal disease have in common several risk factors, being hyperthyroidism and smoking habits the most important ones. There is scarce information in the literature about the association between periodontal disease and osteoporosis and/or osteopenia. Some works suggest that osteoporotic women are susceptible to a higher loss of periodontal insertion, alveolar bones, and teeth. Thirty adult post-menopausic women were studied; some of them were healthy (control group) and the rest of them were undergoing some stage of osteoporosis or osteopenia. All the subjects were healthy, non-smokers, not having dental implants, and with communitarian periodontal index higher than 1(CPI > 1). Samples of saliva and gingival crevice fluid were extracted with calibrated micro-capillaries and deposited on Si reflectors. Known amounts of Ga were added to the samples in order to act as internal standard for quantification by the total reflection x-ray fluorescence technique. Experimental concentrations of several elements (P, S, Cl, K, Ca, Cr, Fe, NI, Cu, and Zn) were determined. The concentration of some elements in saliva showed different behavior as compared to gingival crevice fluid. Some critical elements of bone composition, such as Ca and Zn, present very distinguishable behavior. Improvements in the statistics are required for a better assessment of a routine method and to establish some correlation with periodontal disease. TXRF seems to be a promising method to evaluate the evolution of osteoporosis.

  15. Total reflection X-ray fluorescence analysis of oral fluids of women affected by osteoporosis and osteopenia

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez, Hector Jorge [Facultad de Matematica Astronomia y Fisica, Universidad Nacional de Cordoba, 5000 Cordoba (Argentina)], E-mail: jsan@famaf.unc.edu.ar; Valentinuzzi, Maria Cecilia [Facultad de Matematica Astronomia y Fisica, Universidad Nacional de Cordoba, 5000 Cordoba (Argentina); Grenon, Miram [Facultad de Odontologia, Universidad Nacional de Cordoba, 5000 Cordoba (Argentina); Abraham, Jose [Facultad de Matematica Astronomia y Fisica, Universidad Nacional de Cordoba, 5000 Cordoba (Argentina)

    2008-12-15

    Osteoporosis is a disease characterized by low bone mass and microarchitectural deterioration of bone tissue, leading to bone fragility and an increased susceptibility to fractures; the early stage of decreased bone density is called osteopenia. More than 200 million people are affected and about 50% of post-menopausic women are expected to develop the disease. Osteoporosis, osteopenia and periodontal disease have in common several risk factors, being hyperthyroidism and smoking habits the most important ones. There is scarce information in the literature about the association between periodontal disease and osteoporosis and/or osteopenia. Some works suggest that osteoporotic women are susceptible to a higher loss of periodontal insertion, alveolar bones, and teeth. Thirty adult post-menopausic women were studied; some of them were healthy (control group) and the rest of them were undergoing some stage of osteoporosis or osteopenia. All the subjects were healthy, non-smokers, not having dental implants, and with communitarian periodontal index higher than 1(CPI > 1). Samples of saliva and gingival crevice fluid were extracted with calibrated micro-capillaries and deposited on Si reflectors. Known amounts of Ga were added to the samples in order to act as internal standard for quantification by the total reflection x-ray fluorescence technique. Experimental concentrations of several elements (P, S, Cl, K, Ca, Cr, Fe, NI, Cu, and Zn) were determined. The concentration of some elements in saliva showed different behavior as compared to gingival crevice fluid. Some critical elements of bone composition, such as Ca and Zn, present very distinguishable behavior. Improvements in the statistics are required for a better assessment of a routine method and to establish some correlation with periodontal disease. TXRF seems to be a promising method to evaluate the evolution of osteoporosis.

  16. Translation and adaption of the interRAI suite to local requirements in Belgian hospitals

    Directory of Open Access Journals (Sweden)

    Wellens Nathalie IH

    2012-09-01

    Full Text Available Abstract Background The interRAI Suite contains comprehensive geriatric assessment tools designed for various healthcare settings. Although each instrument is developed for a particular population, together they form an integrated health evaluation system. The interRAI Acute Care Minimum Data Set (interRAI AC is tailored for hospitalized older persons. Our aim in this study was to translate and adapt the interRAI AC to the Belgian hospital context, where it can be used together with the interRAI Home Care (HC and the interRAI Long Term Care Facility (LTCF. Methods A systematic, comprehensive, and rigorous 10-step approach was used to adapt the interRAI AC to local requirements. After linguistic translation by an official translator, five researchers assessed the translation for appropriate hospital jargon. Three researchers double-checked for translation accuracy and proposed additional items. A provisional version was converted into the three official languages of Belgium—Flemish, French, and German. Next, a multidisciplinary panel of nine experts judged item relevance to the Belgian care context and advised which country-specific items should be added. After these suggestions were incorporated into the interRAI AC, hospital staff from nine Flemish hospitals field-tested the tool in their practice. After evaluating field-test results, we compared the interRAI AC with Belgian versions of the interRAI HC and interRAI LTCF. Next, the Flemish, French, and German versions of the Belgian interRAI portfolio were harmonized. Finally, we submitted the Belgian interRAI AC to the interRAI organization for ratification. Results Eighteen administrative items of the interRAI AC were adapted to the Belgian healthcare context (e.g., usual residence, formal community services prior to admission. Fourteen items assessing the ‘informal caregiver’, and 17 items, including country-specific items, were added (e.g., advanced directive for euthanasia

  17. Translation and adaption of the interRAI Suite to local requirements in Belgian hospitals.

    Science.gov (United States)

    Wellens, Nathalie I H; Flamaing, Johan; Moons, Philip; Deschodt, Mieke; Boonen, Steven; Milisen, Koen

    2012-09-07

    The interRAI Suite contains comprehensive geriatric assessment tools designed for various healthcare settings. Although each instrument is developed for a particular population, together they form an integrated health evaluation system. The interRAI Acute Care Minimum Data Set (interRAI AC) is tailored for hospitalized older persons. Our aim in this study was to translate and adapt the interRAI AC to the Belgian hospital context, where it can be used together with the interRAI Home Care (HC) and the interRAI Long Term Care Facility (LTCF). A systematic, comprehensive, and rigorous 10-step approach was used to adapt the interRAI AC to local requirements. After linguistic translation by an official translator, five researchers assessed the translation for appropriate hospital jargon. Three researchers double-checked for translation accuracy and proposed additional items. A provisional version was converted into the three official languages of Belgium-Flemish, French, and German. Next, a multidisciplinary panel of nine experts judged item relevance to the Belgian care context and advised which country-specific items should be added. After these suggestions were incorporated into the interRAI AC, hospital staff from nine Flemish hospitals field-tested the tool in their practice. After evaluating field-test results, we compared the interRAI AC with Belgian versions of the interRAI HC and interRAI LTCF. Next, the Flemish, French, and German versions of the Belgian interRAI portfolio were harmonized. Finally, we submitted the Belgian interRAI AC to the interRAI organization for ratification. Eighteen administrative items of the interRAI AC were adapted to the Belgian healthcare context (e.g., usual residence, formal community services prior to admission). Fourteen items assessing the 'informal caregiver', and 17 items, including country-specific items, were added (e.g., advanced directive for euthanasia). The interRAI AC was adapted to local requirements using a

  18. Estimation of inbreeding rates and extinction risk of forty one Belgian chicken breeds in 2005 and 2010

    OpenAIRE

    Moula, Nassim; Philippe, François-Xavier; Antoine-Moussiaux, Nicolas; Leroy, Pascal; Michaux, Charles

    2014-01-01

    In Belgium, as generally in Europe, the dominant position of the high producing commercial strains specialized in meat or eggs production threats of extinction the local traditional breeds. In this work, a follow up of the changes in populations size, and the rates of inbreeding of the Belgian poultry breeds, has been carried out in 2005 and 2010. About forty breeds were concerned. The Belgian hen breeds being overwhelmingly under threat of extinction, because of the low number of individu...

  19. Endogenous androgens and carotid intimal-medial thickness in women.

    Science.gov (United States)

    Bernini, G P; Sgro', M; Moretti, A; Argenio, G F; Barlascini, C O; Cristofani, R; Salvetti, A

    1999-06-01

    The influence of endogenous androgens on atherosclerotic disease in women is unknown. In this study involving 101 pre- and post-menopausal females, we evaluated the relationship between serum androgen levels and both carotid artery intimal-medial thickness (IMT) and major cardiovascular risk factors. In addition to evaluation of blood pressure, body mass index, and waist-to-hip ratio, serum dehydroepiandrosterone sulfate (DHEA-S), androstenedione (A), total testosterone (TTS), free testosterone (FTS), insulin, cholesterol (total and high density lipoproteins), triglycerides, and glucose were measured. All women underwent carotid ultrasonography. Spearman correlation coefficients showed that serum DHEA-S and A levels were negatively related (P body mass index (P < 0.02). Stepwise multiple regression analysis indicated that A and FTS showed an inverse association with IMT measures (P < 0.05-0.001). In conclusion, our data indicate that in women serum DHEA-S and androgens decline with age and that normal hormonal levels are not associated with major cardiovascular risk factors. They also show that higher DHEA-S and androgen concentrations are related to lower carotid wall thickness; for A this association is independent of cardiovascular risk factors. Our results suggest that, in the physiological range, DHEA-S and androgens in women are correlated with lower risk of carotid artery atherosclerosis.

  20. Seismic qualification of the primary loop of the non-seismically designed Belgian NPP

    International Nuclear Information System (INIS)

    Detroux, P.; Van Vyve, J.

    1989-01-01

    This paper describes the non linear time history analysis performed to seismically qualify the primary loop of the three first Belgian PWR plants. These plants (Chooz A 300 MWe - commissioned in 1966, and Doel 1/2 2 x 390 MWe - commissioned in 1974 and 1975) were not seismically designed, no seismic event being specified at that time. But, after respectively 20 years and 10 years of operation, the safety authorities required to seismically qualify the primary loop of these plants, for a SSE event. Both primary loops and, particularly, the Chooz A primary loop, have a supporting system that differs from the other seismically qualified Belgian NPP. A seismic qualification by analogy was thus not possible, but they are equipped with restraints designed for LOCA/SLB that will certainly be active in case of an SSE

  1. The influence of a smoking ban on the profitability of Belgian restaurants.

    Science.gov (United States)

    De Schoenmaker, Sofie; Van Cauwenberge, Philippe; Vander Bauwhede, Heidi

    2013-05-01

    To examine whether the nationwide smoking ban, imposed in 2007, had an impact on the profitability of Belgian restaurants. Objective financial reporting data on 1613 restaurants were analysed with return on assets as the outcome measure. The data were collected from the Belfirst database and cover the period 2004-2009. To assess the impact of the smoking ban, a differences-in-differences estimation method was used, with bars serving as the control group. The regression model was estimated, while controlling for firm-specific characteristics and unobserved firm-level heterogeneity. The variable of interest is the interaction between the smoking ban dummy and the dummy for the treatment group. The coefficient of this variable is insignificant. The adoption of the nationwide smoking ban did not affect the profitability of Belgian restaurants.

  2. Application of American and French rules for the next belgian PWR

    International Nuclear Information System (INIS)

    Roch, M.; Cavaco, A.

    1987-01-01

    The licensing practice in Belgium is evolving from the precedent compliance with the USNRC rules (as applied to the 4 last Belgian PWRs) to a more sophisticated approach applied to the next Belgian PWR (N8), which incorporates a mixed compliance with the USNRC or with French rules, depending on the equipment, the structure or the system considered. In this paper, we present the approach concerning the licensing rules applicable to N8. The following aspects are covered: rules applicable to the NSSS; rules applicable to the BOP (codes of design for systems and structures); rules applicable to the equipment (code of construction for mechanical and electrical components); impact on the lay-out of the plant. Some examples of application of this methodology are given. (author)

  3. Characterization of a dopamine transporter polymorphism and behavior in Belgian Malinois

    OpenAIRE

    Lit, Lisa; Belanger, Janelle M; Boehm, Debby; Lybarger, Nathan; Haverbeke, Anouck; Diederich, Claire; Oberbauer, Anita M

    2013-01-01

    Abstract Background The Belgian Malinois dog breed (MAL) is frequently used in law enforcement and military environments. Owners have reported seizures and unpredictable behavioral changes including dogs’ eyes “glazing over,” dogs’ lack of response to environmental stimuli, and loss of behavioral inhibition including owner-directed biting behavior. Dogs with severe behavioral changes may be euthanized as they can represent a da...

  4. How does the average Belgian view nuclear technology? Barometer assesses knowledge and risk perception

    International Nuclear Information System (INIS)

    Turcanu, C.; Perko, T.

    2011-01-01

    Irrespective of the choices made in the future, questions about nuclear safety, radiation protection and waste management will always be of topical interest. SCK-CEN has consciously opted for social research on risk perception, sustainable development, and communication. SCK-CEN founded the Barometer in 2002 in order to keep both feet firmly planted in society: a regular, large-scale survey amongst the Belgian population on radiation and nuclear technology. The findings of the third edition were published in 2010.

  5. Reactor pressure vessel steels[1997 Scientific Report of the Belgian Nuclear Research Centre

    Energy Technology Data Exchange (ETDEWEB)

    Van De Velde, J.; Fabry, A.; Van Walle, E.; Chaouuadi, R.

    1998-07-01

    Research and development activities related to reactor pressure vessel steels during 1997 are reported. The objectives of activities of the Belgian Nuclear Research Centre SCK/CEN in this domain are: (1) to develop enhanced surveillance concepts by applying micromechanics and fracture-toughness tests to small specimens, and by performing damage modelling and microstructure characterization; (2) to demonstrate a methodology on a broad database; (3) to achieve regulatory acceptance and industrial use.

  6. Human African trypanosomiasis in a Belgian traveller returning from the Masai Mara area, Kenya, February 2012.

    Science.gov (United States)

    Clerinx, J; Vlieghe, E; Asselman, V; Van de Casteele, S; Maes, M B; Lejon, V

    2012-03-08

    A Belgian traveller was diagnosed with human African trypanosomiasis (HAT) due to Trypanosoma brucei rhodesiense nine days after visiting the Masai Mara area in Kenya. He presented with an inoculation chancre and was treated with suramin within four days of fever onset. Two weeks earlier, HAT was also reported in a German traveller who had visited the Masai Mara area. Because no cases have occurred in the area for over 12 years, this may indicate a focal cluster of HAT.

  7. Changes in body fat distribution through menopause increase blood pressure independently of total body fat in middle-aged women: the Korean National Health and Nutrition Examination Survey 2007-2010.

    Science.gov (United States)

    Park, Jin Kyu; Lim, Young-Hyo; Kim, Kyung-Soo; Kim, Soon Gil; Kim, Jeong Hyun; Lim, Heon Gil; Shin, Jinho

    2013-05-01

    Blood pressure in women increases sharply in middle age, especially after menopause. As the menopausal transition is known to induce changes in body fat distribution, the aim of this study was to investigate the effect of body fat distribution as compared with the effect of total body fat on blood pressure through the menopausal transition. We analyzed 1422 subjects aged 45-55 years using the database from the Korean National Health and Nutrition Examination Survey 2007-2010. The waist circumference (WC) of post-menopausal women was larger than that of pre-menopausal women (80.44 cm, 95% confidence interval (CI) 79.36-81.52 vs. 78.94 cm, 95% CI 78.27-79.61, P=0.013), but there was no statistically significant difference in body mass index (BMI). Systolic and diastolic blood pressure (SBP and DBP) were significantly higher in post-menopausal women than in pre-menopausal women: SBP was 118.33 mm Hg, 95% CI 116.52-120.15 vs. 115.22 mm Hg, 95% CI 114.17-116.28 (P=0.003) and DBP was 76.94 mm Hg, 95% CI 75.88-77.99 vs. 75.25 mm Hg, 95% CI 74.57-75.93 (P=0.009). BMI and WC were positively correlated with BP. After adjustment for BMI, the correlation of WC with SBP remained significant (β=0.250, 95% CI 0.024-0.476, P=0.030). In a stratified analysis, WC correlated with SBP in women with BMIchanges in body fat distribution through the menopausal transition are associated with SBP, independent of total body fat. This finding indicates that alterations in the localization of body fat are another cause of menopause-related changes in BP.

  8. Socioeconomic position, population density and site-specific cancer mortality: A multilevel analysis of Belgian adults, 2001-2011.

    Science.gov (United States)

    Hagedoorn, Paulien; Vandenheede, Hadewijch; Vanthomme, Katrien; Gadeyne, Sylvie

    2018-01-01

    Our study explores the association between individual and neighborhood socioeconomic position (SEP) and all-cancer and site-specific cancer mortality. Data on all Belgian residents are retrieved from a population-based dataset constructed from the 2001 census linked to register data on emigration and mortality for 2001-2011. The study population contains all men and women aged 40 years or older during follow-up. Individual SEP is measured using education, employment status and housing conditions. Neighborhood SEP is measured by a deprivation index (in quintiles). Directly age-standardized mortality rates and multilevel Poisson models are used to estimate the association between individual SEP and neighborhood deprivation and mortality from all-cancer and cancer of the lung, colon and rectum, pancreas, prostate and female breast. The potential confounding role of population density is assessed using multilevel models as well. Our findings show an increase in mortality from all-cancer and site-specific cancer by decreasing level of individual SEP for both men and women. In addition, individuals living in highly deprived neighborhoods experience significantly higher mortality from all-cancer, lung cancer, pancreatic cancer and female colorectal cancer after controlling for individual SEP. Male colorectal and prostate cancer and female breast cancer are not associated with neighborhood deprivation. Population density acts as a confounder for female lung cancer only. Our study indicates that deprivation at both the individual and neighborhood level is associated with all-cancer mortality and mortality from several cancer sites. More research into the role of life-style related and clinical factors is necessary to gain more insight into causal pathway. © 2017 UICC.

  9. Determination of contamination pathways of phthalates in food products sold on the Belgian market.

    Science.gov (United States)

    Van Holderbeke, Mirja; Geerts, Lieve; Vanermen, Guido; Servaes, Kelly; Sioen, Isabelle; De Henauw, Stefaan; Fierens, Tine

    2014-10-01

    As numerous studies have indicated that food ingestion is the most important exposure pathway to several phthalates, this study aimed to determine possible contamination pathways of phthalates in food products sold on the Belgian market. To do this, concentrations of eight phthalates (dimethyl phthalate (DMP), diethyl phthalate (DEP), diisobutyl phthalate (DiBP), di-n-butyl phthalate (DnBP), benzylbutyl phthalate (BBP), dicyclohexyl phthalate (DCHP), di(2-ethylhexyl) phthalate (DEHP) and di-n-octyl phthalate (DnOP)) were determined in 591 foods and 30 packaging materials. In general, the four most prominent phthalates in Belgian food products were DEHP, DiBP, DnBP and BBP. Special attention was given to the origin of these phthalates in bread, since high phthalate concentrations (especially DEHP) were determined in this frequently consumed food product. Phthalates seemed to occur in Belgian bread samples due to the use of contaminated ingredients (i.e. use of contaminated flour) as well as due to migration from phthalate containing contact materials used during production (e.g. coated baking trays). Also the results of the conducted concentration profiles of apple, bread, salami and two cheese types revealed the important role of processing - and not packaging - on phthalate contents in foods. Copyright © 2014 Elsevier Inc. All rights reserved.

  10. Detection of noroviruses in shellfish and semiprocessed fishery products from a Belgian seafood company.

    Science.gov (United States)

    Li, Dan; Stals, Ambroos; Tang, Qing-Juan; Uyttendaele, Mieke

    2014-08-01

    Shellfish have been implicated in norovirus (NoV) infection outbreaks worldwide. This study presents data obtained from various batches of shellfish and fishery products from a Belgian seafood company over a 6-month period. For the intact shellfish (oysters, mussels, and clams), 21 of 65 samples from 12 of 34 batches were positive for NoVs; 9 samples contained quantitative NoV levels at 3,300 to 14,300 genomic copies per g. For the semiprocessed fishery products (scallops and common sole rolls with scallop fragments), 29 of 36 samples from all eight batches were positive for NoVs; 17 samples contained quantitative NoV levels at 200 to 1,800 copies per g. This convenience study demonstrated the performance and robustness of the reverse transcription quantitative PCR detection and interpretation method and the added value of NoV testing in the framework of periodic control of seafood products bought internationally and distributed by a Belgian seafood processing company to Belgian food markets.

  11. Last developments in the Belgian disposal programme for low and intermediate short-lived waste

    International Nuclear Information System (INIS)

    Boyazis, Jean-Paul

    2006-01-01

    After an historical reminder of the several phases of the Belgian program for the disposal of low and medium level short-lived waste since the creation of ONDRAF/NIRAS and the bad results obtained in the 90's by using a pure technical approach, the presentation will explain the main lines of the new methodology developed, as a consequence of the government decision of 16 January 1998 in ONDRAF/NIRAS to improve local acceptance for the disposal project. The way local partnerships were created with four nuclear municipalities under the form of a non-profit organization with a clear mission, the functioning, on a voluntary base, of the different partnerships during four to six years and the concrete results obtained until now using this very innovative method will be addressed. The last developments of the Belgian program for the disposal of low and medium level and short-lived waste will be presented, including the recent and very important decision of the Belgian government of 23 June 2006 to dispose of the low and medium active short-lived waste in a surface disposal installation on the territory of the municipality Dessel. (author)

  12. Microbial diversity and metabolite composition of Belgian red-brown acidic ales.

    Science.gov (United States)

    Snauwaert, Isabel; Roels, Sanne P; Van Nieuwerburg, Filip; Van Landschoot, Anita; De Vuyst, Luc; Vandamme, Peter

    2016-03-16

    Belgian red-brown acidic ales are sour and alcoholic fermented beers, which are produced by mixed-culture fermentation and blending. The brews are aged in oak barrels for about two years, after which mature beer is blended with young, non-aged beer to obtain the end-products. The present study evaluated the microbial community diversity of Belgian red-brown acidic ales at the end of the maturation phase of three subsequent brews of three different breweries. The microbial diversity was compared with the metabolite composition of the brews at the end of the maturation phase. Therefore, mature brew samples were subjected to 454 pyrosequencing of the 16S rRNA gene (bacteria) and the internal transcribed spacer region (yeasts) and a broad range of metabolites was quantified. The most important microbial species present in the Belgian red-brown acidic ales investigated were Pediococcus damnosus, Dekkera bruxellensis, and Acetobacter pasteurianus. In addition, this culture-independent analysis revealed operational taxonomic units that were assigned to an unclassified fungal community member, Candida, and Lactobacillus. The main metabolites present in the brew samples were L-lactic acid, D-lactic acid, and ethanol, whereas acetic acid was produced in lower quantities. The most prevailing aroma compounds were ethyl acetate, isoamyl acetate, ethyl hexanoate, and ethyl octanoate, which might be of impact on the aroma of the end-products. Copyright © 2016 Elsevier B.V. All rights reserved.

  13. Air crew exposure on board of long-haul flights of the Belgian airlines

    International Nuclear Information System (INIS)

    Verhaegen, F.; Poffijn, A.

    2000-01-01

    New European radiation protection recommendations state that measures need to be taken for flight crew members whose annual radiation exposure exceeds 1 mSv. This will be the case for flight crew members who accumulate most of their flying hours on long-haul flights. The Recommendations for the Implementation of the Basic Safety Standards Directive states that for annual exposure levels between 1 and 6 mSv individual dose estimates should be obtained, whereas for annual exposures exceeding 6 mSv, which might rarely occur, record keeping with appropriate medical surveillance is recommended. To establish the exposure level of Belgian air crews, radiation measurements were performed on board of a total of 44 long-haul flights of the Belgian airlines. The contribution of low linear energy transfer (LET) radiation (photons, electrons, protons) was assessed by using TLD-700H detectors. The exposure to high-LET radiation (mostly neutrons) was measured with bubble detectors. Results were compared to calculations with an adapted version of the computer code CARI. For the low-LET radiation the calculations were found to be in good agreement with the measurements. The measurements of the neutron dose were consistently lower than the calculations. With the current flight schedules used by the Belgian airlines, air crew members are unlikely to receive annual doses exceeding 4 mSv. (author)

  14. Osteoporosis, vertebral fractures and metabolic syndrome in postmenopausal women.

    Science.gov (United States)

    El Maghraoui, Abdellah; Rezqi, Asmaa; El Mrahi, Salwa; Sadni, Siham; Ghozlani, Imad; Mounach, Aziza

    2014-12-10

    The combined effect of the metabolic syndrome (MS) risk factors on bone health has led to controversial results and it is still not clear whether this effect is protective or detrimental. The study aimed to examine the association between MS and bone mineral density (BMD), osteoporosis, and vertebral fractures (VFs) among ambulatory older postmenopausal women. 270 post-menopausal women with a mean age of 61.0 years ± 7.8 (50 to 90) with no prior known diagnosis of osteoporosis were recruited. BMD and Lateral vertebral fracture assessment (VFA) images were obtained using a GE Healthcare Lunar Prodigy densitometer. VFs were defined using a combination of Genant semiquantitative approach and morphometry. The MS as defined by the NCEP-ATP III was present in 62 women (23.0%). According to the WHO classification, 82 had osteoporosis at any site (30.4%). VFs were identified in 116 (43.0%): 80 (29.6%) had grade 1 and 36 (13.3%) had grade 2 or 3. Women with MS had a significantly higher BMD and lower prevalence of osteoporosis (17.7% vs. 34.1%) than those without MS. No significant statistical difference was noted in prevalence of VFs (14.5 vs. 13.0%). There were significantly less women with MS among the group of osteoporotic women (13% vs. 27%; p = 0.018). Conditional regression binary analysis assessing the presence of osteoporosis as the dependent variable showed that women with a MS had a significant 71% decrease in the odds of being osteoporotic by BMD compared with women who had not MS accounting for age, BMI, number of parities and years since menopause. Women with MS had higher BMD at the hip and spine, suggesting a protective effect of MS on bone. However, the prevalence of VFs was similar between women with or without MS.

  15. Occurrence of Organophosphorus Flame Retardants and Plasticizers (PFRs) in Belgian Foodstuffs and Estimation of the Dietary Exposure of the Adult Population.

    Science.gov (United States)

    Poma, Giulia; Sales, Carlos; Bruyland, Bram; Christia, Christina; Goscinny, Séverine; Van Loco, Joris; Covaci, Adrian

    2018-02-20

    The occurrence of 14 organophosphorus flame retardants and plasticizers (PFRs) was investigated in 165 composite food samples purchased from the Belgian market and divided into 14 food categories, including fish, crustaceans, mussels, meat, milk, cheese, dessert, food for infants, fats and oils, grains, eggs, potatoes and derived products, other food (stocks), and vegetables. Seven PFRs [namely, tri-n-butyl phosphate (TnBP), tris(2-chloroethyl) phosphate (TCEP), tris(1-chloro-2-propyl) phosphate (TCIPP), tris(1,3-dichloro-2-propyl) phosphate (TDCIPP), triphenyl phosphate (TPHP), 2-ethylhexyldiphenyl phosphate (EHDPHP), and tris(2-ethylhexyl) phosphate (TEHP)] were detected at concentrations above quantification limits. Fats and oils were the most contaminated category, with a total PFR concentration of 84.4 ng/g of wet weight (ww), followed by grains (36.9 ng/g of ww) and cheese (20.1 ng/g of ww). Our results support the hypothesis that PFR contamination may occur during industrial processing and manipulation of food products (e.g., packaging, canning, drying, etc.). Considering the daily average intake of food for the modal adult Belgian (15-64 years of age), the dietary exposure to sum PFRs was estimated to be ≤7500 ± 1550 ng/day [103 ± 21 ng/kg of body weight (bw)/day]. For individual PFRs, TPHP contributed on average 3400 ng/day (46.6 ng/kg of bw/day), TCIPP 1350 ng/day (18.5 ng/kg of bw/day), and EHDPHP 1090 ng/day (15 ng/kg of bw/day), values that were lower than their corresponding health-based reference doses. The mean dietary exposure mainly originated from grains (39%), followed by fats and oils (21%) and dairy products (20%). No significant differences between the intakes of adult men and women were observed.

  16. Relation with HOMA-IR and thyroid hormones in obese Turkish women with metabolic syndrome.

    Science.gov (United States)

    Topsakal, S; Yerlikaya, E; Akin, F; Kaptanoglu, B; Erürker, T

    2012-03-01

    The aim of this study was to investigate the relationship between insulin resistance and thyroid function in obese pre- and postmenopausal women with or without metabolic syndrome (MetS). 141 obese women were divided into two groups, HOMA-IRHOMA-IR>2.7, to evaluate relation with HOMA-IR and fatness, hormone and blood parameters. They were then divided into four groups as pre- and postmenopausal with or without MetS. Various fatness, hormone and blood parameters were examined. Statistically significant difference was found in weight, body mass index (BMI), waist circumference, fat%, fasting insulin, TSH, FT3, FT4, FSH, Anti-microsomal antibody (ANTIM) and triglycerides levels in HOMA-IRHOMA-IR>2.7 obese Turkish women. This study showed that age, weight, BMI, waist circumference, fat%, fasting insulin, FT3, ANTIM, FSH, LH, total cholesterol, triglycerides, HDL, HOMA-IR, systolic and diastolic blood pressure levels were related in preand post menopausal status in obese women with or without MetS. Obesity may influence the levels of thyroid hormones and increases the risk of MetS in women. Postmenopausal status with MetS is associated with an increased TSH, FT3 and FT4 levels and HOMA-IR in obese women. Strong relation was observed with MetS and TSH and FT3 levels.

  17. Is cardiovascular risk in women with PCOS a real risk? Current insights.

    Science.gov (United States)

    Papadakis, Georgios; Kandaraki, Eleni; Papalou, Olga; Vryonidou, Andromachi; Diamanti-Kandarakis, Evanthia

    2017-12-01

    Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive aged women. PCOS incorporates not only symptoms related to the reproductive system but also a clustering of systemic metabolic abnormalities that are linked with increased risk for cardiovascular disease (CVD). More specifically, metabolic aberrations such as impaired glucose and lipid metabolism, accompanied by increased low-grade inflammation as well as elevated coagulation factors appear to contribute to the increased cardiovascular risk. Even though many studies have indicated a rise in surrogate biomarkers of CVD in women with PCOS, it is still doubtful to what extent and magnitude this elevation can be translated to real cardiovascular events. Furthermore, the cardiovascular risk factors appear to vary significantly in the different phenotypes of the syndrome. Women with PCOS have the potential for early atherosclerosis, myocardial and endothelial dysfunction. Whether PCOS women are at real cardiovascular risk compared to controls remains between the verge of theoretical and real threat for the PCOS women at any age but particularly in the post-menopausal state. Interestingly, although the presence of the CVD risk factors is well documented in PCOS women, their combination on different phenotypes may play a role, which eventually results in a spectrum of clinical manifestations of CVD with variable degree of severity. The present manuscript aims to review the interaction between PCOS and the combination of several cardiovascular risk factors.

  18. Optimism predicts sustained vigorous physical activity in postmenopausal women

    Directory of Open Access Journals (Sweden)

    Ana M. Progovac

    2017-12-01

    Full Text Available Optimism and cynical hostility are associated with health behaviors and health outcomes, including morbidity and mortality. This analysis assesses their association with longitudinal vigorous physical activity (PA in postmenopausal women of the Women's Health Initiative (WHI. Subjects include 73,485 women nationwide without history of cancer or cardiovascular disease (CVD, and no missing baseline optimism, cynical hostility, or PA data. The Life Orientation Test-Revised Scale measured optimism. A Cook Medley questionnaire subscale measured cynical hostility. Scale scores were divided into quartiles. Vigorous PA three times or more per week was assessed via self-report at study baseline (1994–1998 and through follow-up year 6. Descriptive analysis mapped lifetime trajectories of vigorous PA (recalled at ages 18, 25, 50; prospectively assessed at baseline, and 3 and 6 years later. Hierarchical generalized linear mixed models examined the prospective association between optimism, cynical hostility, and vigorous PA over 6 years. Models adjusted for baseline sociodemographic variables, psychosocial characteristics, and health conditions and behaviors. Vigorous PA rates were highest for most optimistic women, but fell for all women by approximately 60% between age 50 and study baseline. In adjusted models from baseline through year 6, most vs. least optimistic women were 15% more likely to exercise vigorously (p < 0.001. Cynical hostility was not associated with lower odds of longitudinal vigorous PA after adjustment. Results did not differ by race/ethnicity or socioeconomic status. Higher optimism is associated with maintaining vigorous PA over time in post-menopausal women, and may protect women's health over the lifespan.

  19. Midlife women, bone health, vegetables, herbs and fruit study. The Scarborough Fair study protocol.

    Science.gov (United States)

    Gunn, Caroline A; Weber, Janet L; Kruger, Marlena C

    2013-01-10

    Bone loss is accelerated in middle aged women but increased fruit/vegetable intake positively affects bone health by provision of micronutrients essential for bone formation, buffer precursors which reduce acid load and phytochemicals affecting inflammation and oxidative stress. Animal studies demonstrated bone resorption inhibiting properties of specific vegetables, fruit and herbs a decade ago. To increase fruit/vegetable intake in post menopausal women to 9 servings/day using a food specific approach to significantly reduce dietary acid load and include specific vegetables, fruit and herbs with bone resorbing inhibiting properties to assess effect on bone turnover, metabolic and inflammatory markers. The Scarborough Fair Study is a randomised active comparator controlled multi centre trial. It aimed to increase fruit and vegetable intake in 100 post menopausal women from ≤ 5 servings/day to ≥ 9 servings/day for 3 months. The women in the dietary intervention were randomly assigned to one of the two arms of the study. Both groups consumed ≥ 9 servings/day of fruit/vegetables and selected herbs but the diet of each group emphasised different fruit/vegetables/herbs with one group (B) selecting from a range of vegetables, fruit and culinary herbs with bone resorbing inhibiting properties. 50 women formed a negative control group (Group C usual diet). Primary outcome variables were plasma bone markers assessed at baseline, 6 weeks and 12 weeks. Secondary outcome variables were plasma inflammation and metabolic markers and urinary electrolytes (calcium, magnesium, potassium and sodium) assessed at baseline and 12 weeks. Dietary intake and urine pH change also were outcome variables. The dietary change was calculated with 3 day diet diaries and a 24 hour recall. Intervention participants kept a twice weekly record of fruit, vegetable and herb intake and urine pH. This study will provide information on midlife women's bone health and how a dietary intervention

  20. The Belgian nuclear higher education network: the evolution of an academic programme in nuclear engineering

    International Nuclear Information System (INIS)

    Berkvens, T.; Coeck, M.

    2014-01-01

    The master-after-master in nuclear engineering provided by the Belgian Nuclear higher Education Network (BNEN) is a one-year, 60 ECTS programme which combines the expertise of six Belgian universities and SCK.CEN, the Belgian Nuclear Research Centre, which participates through its Academy for Nuclear Science and Technology. It was created in close collaboration with representatives of academia, research centres, industry and other nuclear stakeholders. The BNEN consortium Due to its modular programme, BNEN is accessible for both full-time students (mainly young engineering graduates) as well as young professionals already employed in the nuclear industry. The programme is offered in English to facilitate the participation of international students. One of the important aspects of the BNEN programme is the fact that exercises and hands-on sessions in the specialised laboratories of SCK.CEN complement the theoretical classes to bring the students into contact with all facets of nuclear energy. Several of SCK.CEN's researchers provide valuable contributions to the programme through seminars and practical exercises. From their daily practices and responsibilities they give an expert view on the subjects that are being taught. In 2012, in the framework of an official accreditation process all aspects of the BNEN programme were audited by an international visitation panel. The most important outcome of this process is the current reform of the academic programme, which will be implemented in the academic year 2014-2015, taking into account the recommendations by the visitation panel. In this paper, the history of the BNEN programme will be discussed, the new BNEN programme will be presented as well as the process that has led to its implementation. (authors)

  1. Hydrophilic interaction chromatography and evaporative light scattering detection for the determination of polar analytes in Belgian endive.

    Science.gov (United States)

    Annaratone, Carlo; De Roeck, Ans; Hertog, Maarten L A T M; Nicolaï, Bart M

    2017-08-15

    Belgian endive (Cichorium intybus L. var. foliosum Hegi), a popular produce in northern Europe, has been thoroughly studied in regard to its bitter sesquiterpene lactones content. Much less is known about on its sweetness and crunchiness, which are typically linked to the content of polar compounds such as sugars, organic acids and salts. Through HILIC-HPLC-MS, it was shown that simple sugars, amino acids, and potassium chloride are abundant in Belgian endive extracts. Subsequently, a HILIC-HPLC-ELSD method for the analysis of such compounds with run times below six minutes was developed. Recoveries varied between 80 and 110% and an average reproducibility was 7.5RSD%. Finally, the method was applied to the study of three difference Belgian endive varieties. Takine, a variety known for its sweet taste, was found to contain significantly higher levels of fructose, and lower levels of potassium and glutamine. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. [Menopause-related symptoms in middle-aged women residing in the Zaragoza Province].

    Science.gov (United States)

    Pérez-Roncero, Gonzalo Ramón; Martínez-Dearth, Rebeca; López-Baena, María Teresa; Ornat-Clemente, Lía

    2013-01-01

    The aim of this study was to assess menopausal symptoms and related sociodemographic conditions in middle-aged women from the Spanish province of Zaragoza. This was a cross-sectional study in which 241 women (40-59 years old) from the Zaragoza province completed the Menopause Rating Scale (MRS) and a sociodemographic questionnaire containing personal and partner data to assess symptoms associated with the menopause. The most prevalent symptoms were musculoskeletal, followed by hot flushes and perspiration. Somatic, psychological and urogenital symptoms were more severe in post-menopausal women. Somatic and urogenital symptoms worsen with age, body mass index, age at menopause, and partner age. Multiple linear regression analysis (MA) for somatic symptoms was related with the menopausal status, psychiatric treatment, problems with sexual relationships, and history of gender violence. The MA for psychological symptoms was associated with menopausal status, psychiatric treatment and a history of gender violence. The MA for urogenital symptoms was associated with menopausal status, problems with sexual relationships, urinary incontinence and partner alcohol abuse. A history of gender violence was reported by 11.6% of the women. In this sample of middle-aged women, menopausal symptoms were related to menopausal status, and other factors associated with their partner factors, including gender violence. Copyright © 2013 Elsevier España, S.L. All rights reserved.

  3. Assessing the Risk of K-loss within the Belgian TSO

    International Nuclear Information System (INIS)

    Bernard, B.

    2016-01-01

    Full text: Organisations lose knowledge. Considering knowledge as a valuable asset, attention must be paid to the risk of losing it. The contribution of this paper is to propose a model—the knowledge critical grid (KCG)—that aims at assessing the risk of knowledge loss. Applied within the Belgian TSO, this model focuses on community-of-practices and network issues. Grounded on five knowledge issues, the KCG intends to assess the knowledge volatility and vulnerability levels of an organisation and define the best relevant knowledge management actions. (author).

  4. Determining the marketing mix for a start-up travel agency aimed at the Belgian market

    OpenAIRE

    Hanák, Marek

    2014-01-01

    This thesis suggests a marketing mix consisting of 4 P's for a start-up travel agency. It created a product according to the quantitative research, n=140, and a qualitative research on the Belgian market. It includes the price of the product according to a competitor analysis, price expectation of the segment and a calculation of all costs connected with providing the service. It suggests also a promotion strategy aimed at the target audience and describes the place in terms point of sale ded...

  5. Age diversity practices through an OD approach. Interventions in Belgian organizations

    OpenAIRE

    MARTENS, Hilda; LAMBRECHTS, Frank; DE WEERDT, Sven; VANDENBERK, Anneleen

    2005-01-01

    People need to work longer. Belgian legal regulations do not stimulate people to work longer. This will change in the future. Organizations will have to keep their workforce until the age of 60 to 65 instead of to 50 or 55. A (pro-)active change in mindset and behaviour of management, HR, workers, unions thus of all stakeholders of the organization is needed. How can we, by using an OD approach (OD), initiate and install a dynamic to make that the different parties, HR, management, workers an...

  6. Contamination levels observed on the Belgian territory subsequent to the Chernobyl accident

    International Nuclear Information System (INIS)

    Cottens, E.

    1986-01-01

    A summary of the data from different laboratories concerning the fallout on the Belgian territory following the Chernobyl emissions is presented. The evolution of the particulate air activity at ground level, the integrated fallout captured in water, the deposition on soil surface directly for different localities in Belgium are given. The grass contamination, the milk contamination from individual farms, the concentration levels on leafy vegetables, surface waters and water basins and the contamination of meat during the month of May are presented. (A.F.)

  7. Methods used to seismically upgrade. The safety related components of Belgian plants

    International Nuclear Information System (INIS)

    Lafaille, J.P.

    1993-01-01

    Belgian nuclear power amounts to about 6,000 MW, generated by seven plants that started operation as early as 1967. The latest plant started in 1985. Some of these plants were designed with no seismic requirements whatsoever. Even for those that had seismic requirements at the design stage, seismic demand was raised after design had been frozen (late during construction or at the 10 years revision). As a consequence all the plants had to undergo, to a variable extent, a seismic reevaluation and/or backfitting. Civil structures were concerned as well as electro-mechanical equipment and piping systems. The present paper deals with the mechanical aspect of the problem (equipment and piping). In order to minimize hardware modifications, advanced analytical techniques were used throughout the process, starting with the elaboration of a site specific spectrum, and using a full soil-structure interaction in order to get as 'realistic' as possible floor response spectra. In some instances, non linear elasto-plastic time history analysis was performed on piping-systems in order to qualify them without hardware modifications. In other cases a 'Load Coefficient Method' was used. Sometimes stresses or displacements taken from the original stress reports and scaled by comparison of applicable spectra, allowed to assess the seismic validity of the system under investigation. Seismic acceptability of installed active equipment is more difficult to demonstrate, as this is usually done by testing. This problem is a generic issue in the US, identified under the label USI-A-46 (Unresolved Safety Issue). It is treated by. a group of Utilities (SQUG = Seismic Qualification Utilities Group). The Belgian Utility is member of that group since 1985. The application of this program is starting in the US. SQUG methodology has been applied to three Belgian plants starting in 1988 and is now completed. The required fixes are being implemented. Experience gained in the process has been applied

  8. The GAy MEn Sex StudieS erectile dysfunction among Belgian gay men

    Directory of Open Access Journals (Sweden)

    Vansintejan J

    2013-07-01

    Full Text Available Johan Vansintejan, Jan Vandevoorde, Dirk Devroey Department of Family Medicine, Vrije Universiteit Brussel (VUB, Brussels, Belgium Aim: To determine the prevalence of erectile dysfunction (ED in a sample of the Belgian men who have sex with men (MSM population, and to assess the relevance of major predictors such as age, relationship, and education. We investigated the use of phosphodiesterase type 5 (PDE5 inhibitors among Belgian MSM. Methods: An internet-based survey on sexual behavior and sexual dysfunctions, called GAy MEn Sex StudieS (GAMESSS, was administered to MSM, aged 18 years or older, between the months of April and December 2008. The questionnaire used was a compilation of the Kinsey's Heterosexual–Homosexual Rating Scale, Erection Quality Scale (EQS, and the shortened version of the International Index of Erectile Function (IIEF-5. Results: Of the 1752 participants, 45% indicated having some problems getting an erection. In this group of MSM, 71% reported mild ED; 22% mild to moderate ED; 6% moderate ED; and 2% severe ED. Independent predictors for the presence of ED were: age (odds ratio [OR] = 1.04, P < 0.0001, having a steady relationship (OR = 0.59, P < 0.0001, frequency of sex with their partner (OR = 1.22, P < 0.0001, versatile sex role (OR = 1.58, P = 0.016, passive sex role (OR = 3.12, P < 0.0001, problems with libido (OR = 1.15, P = 0.011, ejaculation problems (OR = 1.33, P < 0.0001, and anodyspareunia (OR = 0.87, P < 0.0001. Ten percent of the Belgian MSM used a PDE5 inhibitor (age 43 ± 11 years; mean ± standard deviation and 83% of them were satisfied with the effects. "Street drugs" were used by 43% of MSM to improve ED. Conclusion: Forty-five percent of participating Belgian MSM reported some degree of ED and 10% used a PDE5 inhibitor to improve erections. Older MSM reported more ED. MSM, who were in a steady relationship or frequently had sex with a partner, reported less ED. MSM with ejaculation problems

  9. Protocol of the Belgian food consumption survey 2014: objectives, design and methods.

    Science.gov (United States)

    Bel, Sarah; Van den Abeele, Sofie; Lebacq, Thérésa; Ost, Cloë; Brocatus, Loes; Stiévenart, Charlotte; Teppers, Eveline; Tafforeau, Jean; Cuypers, Koenraad

    2016-01-01

    Dietary patterns are one of the major determinants as far as health and burden of disease is concerned. Food consumption data are essential to evaluate and develop nutrition and food safety policies. The last national food consumption survey in Belgium took place in 2004 among the Belgian population aged 15 years and older. Since dietary habits are prone to change over time a new Belgian National Food Consumption Survey (BNFCS2014) was conducted in 2014-2015. The BNFCS2014 is a cross-sectional study. A representative sample (n = 3200) of the Belgian population aged 3 to 64 years old was randomly selected from the National Population Register following a multistage stratified sampling procedure. Data collection was divided equally over the four seasons and days of the week in order to incorporate seasonal effects and day-to-day variation in food intake. Information on food intake was collected in adults with two non-consecutive 24-h dietary recalls (using the GloboDiet® software). In children food intake was collected with two non-consecutive one-day food diaries followed by a completion interview with GloboDiet. Additional data on socio-demographic characteristics, eating habits, lifestyle, food safety (at household level), physical activity and sedentary behaviour were collected with a face-to-face questionnaire using a computer-assisted personal interviewing technique. In the time between the two visits, participants were asked to complete a self-administered food frequency questionnaire and health questionnaire. Height, weight and waist circumference were measured. In addition, children and adolescents were asked to wear an accelerometer and keep a logbook for seven consecutive days to objectively measure physical activity and sedentary behaviour. The main objective of the BNFCS2014 is to evaluate the habitual food, energy and nutrient intake in the Belgian population and to compare these with recommendations from the national dietary guidelines. A second

  10. Midlife women, bone health, vegetables, herbs and fruit study. The Scarborough Fair study protocol

    Directory of Open Access Journals (Sweden)

    Gunn Caroline A

    2013-01-01

    Full Text Available Abstract Background Bone loss is accelerated in middle aged women but increased fruit/vegetable intake positively affects bone health by provision of micronutrients essential for bone formation, buffer precursors which reduce acid load and phytochemicals affecting inflammation and oxidative stress. Animal studies demonstrated bone resorption inhibiting properties of specific vegetables, fruit and herbs a decade ago. Objective: To increase fruit/vegetable intake in post menopausal women to 9 servings/day using a food specific approach to significantly reduce dietary acid load and include specific vegetables, fruit and herbs with bone resorbing inhibiting properties to assess effect on bone turnover, metabolic and inflammatory markers. Methods/Design The Scarborough Fair Study is a randomised active comparator controlled multi centre trial. It aimed to increase fruit and vegetable intake in 100 post menopausal women from ≤ 5 servings/day to ≥ 9 servings/day for 3 months. The women in the dietary intervention were randomly assigned to one of the two arms of the study. Both groups consumed ≥ 9 servings/day of fruit/vegetables and selected herbs but the diet of each group emphasised different fruit/vegetables/herbs with one group (B selecting from a range of vegetables, fruit and culinary herbs with bone resorbing inhibiting properties. 50 women formed a negative control group (Group C usual diet. Primary outcome variables were plasma bone markers assessed at baseline, 6 weeks and 12 weeks. Secondary outcome variables were plasma inflammation and metabolic markers and urinary electrolytes (calcium, magnesium, potassium and sodium assessed at baseline and 12 weeks. Dietary intake and urine pH change also were outcome variables. The dietary change was calculated with 3 day diet diaries and a 24 hour recall. Intervention participants kept a twice weekly record of fruit, vegetable and herb intake and urine pH. Discussion This study will provide

  11. Legacy of Colonialism in the Empowerment of Women in Rwanda

    Directory of Open Access Journals (Sweden)

    Ilaria Buscaglia

    2012-03-01

    Full Text Available The empowerment of women in Rwanda is rooted in colonial times. In the second half of the 1940s, the Belgian administration, together with religious missionaries, started some educational and social welfare programs for women, known as the foyers sociaux (social homes. This paper explores how this program of female promotion and its progeny affected the domestication of Rwandan women, what caused the situation to change following the genocide against the Tutsi in 1994, and what more might be done to stimulate full gender equality in education and employment for women in Rwanda.

  12. Preventive Care Use among the Belgian Elderly Population: Does Socio-Economic Status Matter?

    Directory of Open Access Journals (Sweden)

    Sarah Hoeck

    2013-12-01

    Full Text Available Objective: To analyze the association between influenza and pneumococcus vaccination and blood cholesterol and blood sugar measurement by Belgian elderly respondents (≥65 years and socio-demographic characteristics, risk factors, health status and socio-economic status (SES. Methods: A cross-sectional study based on 4,544 non-institutionalized elderly participants of the Belgian Health Interview Surveys 2004 and 2008. Multivariate logistic regression models were constructed to examine the independent effect of socio-demographic characteristics, risk factors, health status and SES on the four preventive services. Results: After adjustment for age, sex, region, survey year, living situation, risk factors (body mass index, smoking status, physical activity and health status (self-assessed health and longstanding illness lower educated elderly were significantly less likely to report a blood cholesterol and blood sugar measurement. For instance, elderly participants with no degree or only primary education were less likely to have had a cholesterol and blood sugar measurement compared with those with higher education. Pneumococcus vaccination was not related to educational level, but lower income groups were more likely to have had a pneumococcus immunization. Influenza vaccination was not significantly related to SES. Conclusion: The results highlight the need to promote cholesterol and blood sugar measurement for lower SE groups, and pneumococcus immunization for the entire elderly population. Influenza immunization seems to be equally spread among different SE groups.

  13. The energy sources and nuclear energy - The point of view of the Belgian Catholic Church

    International Nuclear Information System (INIS)

    Hoenraet, Christian

    2000-01-01

    The problems related to the environment are reported regularly to the public by means of the newspapers, on radio and television. The story is the product of a journalistic process and in general does not bear much resemblance to the original event. The rate and type of reportage depend not only on the body of data available to the journalist but on the information sources the journalist chosen to use. The same story is reported in a positive or negative way. Finally people are overwhelmed by contradictory information and became uncertain or frightened. In order to provide the general public with objective information about nuclear energy in particular and to made a statement about the position of the Belgian Catholic Church concerning this matter, the results of the study were published in Dutch under the form of a book with the title 'The Energy Sources and Nuclear Energy - Comparative analysis and ethical thoughts written the same author. Thia paper is a short survey of the results of the study and to present the point of view of the Belgian Catholic Church in the energy debate

  14. Occupational stress, work-home interference and burnout among Belgian veterinary practitioners

    Directory of Open Access Journals (Sweden)

    Hansez I

    2008-04-01

    Full Text Available Abstract There have been few formal studies on stress in veterinary surgeons and, in the rare studies available, stress is not examined jointly through the levels of job strain and job engagement, the sources of stress in the issue of work environment and the work-home interference. The authors' goal in this study was to analyse job engagement, job strain, burnout, work-home interference and job stress factors among 216 Belgian veterinary surgeons. Rural practice was compared to small animal and mixed activity. The mean job strain and job engagement level in veterinary surgeons was not higher than what we found in other working populations. However, 15.6% of the group were found to be suffering from high burnout. Rural practitioners had a lower level of job engagement than small animal veterinary surgeons. These small animal practitioners had a lower level of job strain than the mixed practitioners. The level of burnout did not differ significantly across the three types of activity. In comparison to other Belgian and Dutch workers, veterinary surgeons perceived more negative work-home interference. Bovine and mixed practitioners were the most concerned with this problem. The two most important sources of stress reported by bovine practitioners were relations to farmers and working time management (including emergencies and availability.

  15. Contribution of the Belgian hospital physicists association to quality assurance in radiotherapy

    International Nuclear Information System (INIS)

    Hoornaert, M.Th.; Vynckier, S.; Dam, J. van; Bouiller, A.

    1997-01-01

    In 1987, the Belgian Hospital Physicists Association (BHPA) has started a program in order to uniformize the dosimetry in the Belgian radiotherapy centres. Several initiatives were taken: a) Dosimetry, of photon beams: Endorsement of the Dutch dosimetry, code of practice (NCS) (1), calibration of ionisation chambers in a common laboratory (Laboratory for standard dosimetry, RUG), on site visits where, besides mechanical checks of simulators and radiation units, absorbed dose was measured at different locations in a water phantom. Since 1987, a total of 23 centres were visited involving 18 simulators, 17 cobalt units and 22 linear accelerators with 33 photon beams. The energy of those photon beams ranged from 4 to 25 MeV (2). b) Dosimetry of electron beams: Endorsement of the Dutch dosimetry code of practice (3), calibration of several parallel plate chambers following the recommendations of the IAEA (4) and the NCS, on site visits for local measurements in electron beams. This program started last year. three centres were visited with a total of 23 energies ranging from 4.5 to 21 MeV. c) Elaboration of procedures and common reporting form for daily quality control will be published. (author)

  16. Molecular characterization of Belgian pseudorabies virus isolates from domestic swine and wild boar.

    Science.gov (United States)

    Verpoest, Sara; Cay, Ann Brigitte; De Regge, Nick

    2014-08-06

    Aujeszky's disease is an economically important disease in domestic swine caused by suid herpesvirus 1, also called pseudorabies virus (PRV). In several European countries, including Belgium, the virus has successfully been eradicated from the domestic swine population. The presence of PRV in the wild boar population however poses a risk for possible reintroduction of the virus into the domestic pig population. It is therefore important to assess the genetic relatedness between circulating strains and possible epidemiological links. In this study, nine historical Belgian domestic swine isolates that circulated before 1990 and five recent wild boar isolates obtained since 2006 from Belgium and the Grand Duchy of Luxembourg were genetically characterized by restriction fragment length polymorphism (RFLP) analysis and phylogenetic analysis. While all wild boar isolates were characterized as type I RFLP genotypes, the RFLP patterns of the domestic swine isolates suggest that a shift from genotype I to genotype II might have occurred in the 1980s in the domestic population. By phylogenetic analysis, Belgian wild boar isolates belonging to both clade A and B were observed, while all domestic swine isolates clustered within clade A. The joint phylogenetic analysis of both wild boar and domestic swine strains showed that some isolates with identical sequences were present within both populations, raising the question whether these strains represent an increased risk for reintroduction of the virus into the domestic population. Copyright © 2014 Elsevier B.V. All rights reserved.

  17. All-Cause Mortality Among Belgian Military Radar Operators: A 40-Year Controlled Longitudinal Study

    International Nuclear Information System (INIS)

    Degrave, Etienne; Autier, Philippe; Grivegnee, Andre-Robert; Zizi, Martin

    2005-01-01

    Background: It has been suggested that exposure to radiofrequency/microwaves radiations could be associated with greater health hazards and higher mortality. Methods: The all-cause mortality of 27,671 Belgian militaries who served from 1963 until 1994 in battalions equipped with radars for anti-aircraft defence was studied over the period 1968-2003. End of the seventies, technical modifications brought to the shielding of the micro-wave generators resulted in a reduction in irradiations. A control group was formed by 16,128 militaries who served during the same period in the same military area but who were never exposed to radars. Administrative procedures for identifying militaries and their vital status were equivalent in the radar and the control groups. Results: The age-standardized mortality ratio (SMR) in the radar battalions was 1.05 (95% CI: 0.95-1.16) in professional militaries, and 0.80 (95% CI: 0.75-0.85) in conscripts. In professional militaries no difference in mortality was found according to duration (less than, or five years or more) or to period of service (before 1978 or after 1977). Conclusions: During a 40-year period of observation, we found no increase in all-cause mortality in Belgian militaries who were in close contact with radar equipments of anti-aircraft defence battalions

  18. Risk perception of the Belgian population. Results of the public opinion survey in 2006

    International Nuclear Information System (INIS)

    Van Aeken, K.; Turcanu, C.; Bombaerts, G.; Carle, B.; Hardeman, F.

    2007-01-01

    The Belgian Nuclear Research Center SCK-CEN 2006 risk perception barometer is based on over 1000 Computer Assisted Personal Interviews, taken from persons selected to be representative for the Belgian 18+ population, and all realized in the period March 21st to April 12th 2006. Besides the classical background variables used to obtain the quota for representativity (age, language, habitat, gender and social class), we also included a series of questions assessing the sociological context and the psychological personality profile. The main topics in the survey were I) risk perception and confidence in authorities; II) acceptance of legal norms for food products; III) acceptance of countermeasures for the food chain in case of a radiological contamination and associated consumers behaviour; IV) energy; v) disposal of radioactive waste; vi) perception of the Chernobyl accident and its consequences. Some of the questions asked in 2006 are similar to those enquired in the SCK barometer of 2002, in order to study the time evolution of the risk perception associated with various issues. For the part related to acceptance of legal norms and of countermeasures for the food chain, simulated news bulletins were used in order to better reproduce the real-life context of a contamination.

  19. Reforming the Belgian market for orthotic braces: what can we learn from the international experience?

    Science.gov (United States)

    Simoens, Steven; De Coster, Sandra; Moldenaers, Ingrid; Guillaume, Paul; Depoorter, Antony; Van den Steen, Dirk; Van de Sande, Stefaan; Debruyne, Hans; Ramaekers, Dirk; Lona, Murielle

    2008-05-01

    This article aims to review regulation governing outpatient orthotic braces (neck, wrist and knee braces) in France, the Netherlands and Sweden with a view to reforming the Belgian market. Information about the regulatory framework was derived from an analysis of legal texts and a survey completed by national experts. Strategies to keep down prices include public procurement in Sweden, maximum prices in France, and exclusion of expensive braces from reimbursement in the Netherlands. Reimbursement is linked to a medical indication or a chronic condition in France, the Netherlands and Sweden. To gain reimbursement, the cost-effectiveness of orthotic braces needs to be demonstrated in France and the Netherlands. Orthotic braces tend to be initially prescribed by a specialist physician and distributed by orthotists, medical equipment shops and/or community pharmacies. Extensive government intervention exists in the outpatient orthotic brace market in the countries studied. Our recommendations to reform the Belgian market for prefabricated orthotic braces are to separate reimbursement for service provision from reimbursement for braces; to set prices by means of a tendering process or an international price comparison; and to make reimbursement conditional on effectiveness and cost-effectiveness of braces.

  20. Drawing on international experience to reform the Belgian market for ostomy appliances.

    Science.gov (United States)

    Simoens, Steven; Van den Steen, Dirk; Vanleene, Veerle; De Maré, Luc; Moldenaers, Ingrid; Debruyne, Hans; Ramaekers, Dirk

    2007-02-01

    This article aims to review the regulatory framework governing the Belgian ostomy appliance market in the light of the experience of Denmark, France, the Netherlands and Ontario (Canada) with regulation of ostomy appliances. Information about the regulatory framework was derived from the international literature, analysis of legal texts and a survey completed by national experts. The comparative analysis revealed that these countries have adopted varying approaches towards regulating their domestic ostomy appliance market. Strategies to keep down prices include public procurement in Denmark, maximum prices in France and exclusion of expensive appliances from reimbursement in the Netherlands. To contain public expenditure on ostomy appliances, consumption patterns are monitored in the Netherlands, the quantity of reimbursed appliances is limited in Belgium and public reimbursement is restricted in Ontario. Ostomy appliances are generally distributed by community pharmacies and medical equipment shops. In countries that emphasise home care delivery such as Denmark, domiciliary distributors dominate the market to the detriment of community pharmacies which do not seem to be able to offer this service at a competitive price. An avenue for reforming the Belgian ostomy appliance market is proposed which valorizes the role of ostomy care nurses in guiding the choice of ostomy appliances. Furthermore, it is recommended that a competitive tendering process determines the price of ostomy appliances, that reimbursement for service provision by distributors is separated from reimbursement of appliances, and that patients receive a fixed grant from the third-party payer to buy ostomy appliances.

  1. Risk perception of the Belgian population. Results of the public opinion survey in 2006

    Energy Technology Data Exchange (ETDEWEB)

    Van Aeken, K.; Turcanu, C.; Bombaerts, G.; Carle, B.; Hardeman, F.

    2007-01-15

    The Belgian Nuclear Research Center SCK-CEN 2006 risk perception barometer is based on over 1000 Computer Assisted Personal Interviews, taken from persons selected to be representative for the Belgian 18+ population, and all realized in the period March 21st to April 12th 2006. Besides the classical background variables used to obtain the quota for representativity (age, language, habitat, gender and social class), we also included a series of questions assessing the sociological context and the psychological personality profile. The main topics in the survey were I) risk perception and confidence in authorities; II) acceptance of legal norms for food products; III) acceptance of countermeasures for the food chain in case of a radiological contamination and associated consumers behaviour; IV) energy; v) disposal of radioactive waste; vi) perception of the Chernobyl accident and its consequences. Some of the questions asked in 2006 are similar to those enquired in the SCK barometer of 2002, in order to study the time evolution of the risk perception associated with various issues. For the part related to acceptance of legal norms and of countermeasures for the food chain, simulated news bulletins were used in order to better reproduce the real-life context of a contamination.

  2. Belgian surveillance plans to assess changes in Salmonella prevalence in meat at different production stages.

    Science.gov (United States)

    Ghafir, Yasmine; China, Bernard; Korsak, Nicolas; Dierick, Katelijne; Collard, Jean-Marc; Godard, Claudine; De Zutter, Lieven; Daube, Georges

    2005-11-01

    From 1997 to 1999, the prevalence of Salmonella was assessed at different stages through the pork, poultry, and beef meat production chains. Different dilutions of the initial sample suspension were analyzed to provide a semiquantitative evaluation of Salmonella contamination and to determine the most representative dilution necessary to detect a reduction in prevalence. An average of 300 samples for each type of meat were analyzed. According to Fisher's exact test, the dilution to be used to detect a reduction in prevalence was chosen based on an initial prevalence of 20 to 26%. Based on this introductory study, a new sampling plan representative of the nationwide Belgian meat production process was used from 2000 through to 2003. This study confirmed the consistently high rate and level of contamination of poultry meat: broiler and layer carcasses were the most contaminated samples followed by broiler fillets and poultry meat preparations. A constant and significant decrease in Salmonella prevalence was observed for pork carcasses, trimmings, and minced meat and for beef minced meat. Less than 3% of beef carcasses and trimming samples were positive for Salmonella. The Belgian plan, as utilized from 2000 to 2003, was suitable for monitoring of zoonoses because the sampling plan was representative of nationwide production processes, covered all periods of the year, and was executed by trained samplers and the analyses were carried out by recognized laboratories using an identical analytical method.

  3. SCK-CEN 2006 barometer on risk perception of the Belgian population

    International Nuclear Information System (INIS)

    Carle, B.

    2009-01-01

    Starting with 2000, the expert group Society and Policy Support carries out research on various aspects of risk governance. Measuring several risk perception items at regular intervals with the Belgian population is an important part of this research. SCK-CEN has organised a first risk perception barometer in 2002 and a second one in 2006. The 2006 barometer is based on 1063 Computer Assisted Personal Interviews, with a duration of approximately 35 minutes. The large scale of the survey ensures that general trends can be detected and allows specific and detailed analysis on subgroups of the population. Besides the classical background variables used to obtain a sample representative for the Belgian 18+ population (age, language, habitat, gender and social class), several questions were included assessing the sociological context and the psychological personality profile. A series of questions on risk perception, confidence in authorities and specific nuclear topics were repeated in 2006 and constitute a fixed core, allowing comparison over time in Belgium, as well as with the results from the IRSN French barometer. In addition, a number of topics such as acceptance of legal norms and management options for radioactively contaminated milk, energy, nuclear waste and the perception of the Chernobyl accident were covered in detail in the 2006 edition of the SCK-CEN barometer

  4. Focal epilepsy in the Belgian shepherd: evidence for simple Mendelian inheritance.

    Science.gov (United States)

    Berendt, M; Gulløv, C H; Fredholm, M

    2009-12-01

    To establish the mode of inheritance and describe the clinical features of epilepsy in the Belgian shepherd, taking the outset in an extended Danish dog family (199 individuals) of Groenendael and Tervueren with accumulated epilepsy. Epilepsy positive individuals (living and deceased) were ascertained through a telephone interview using a standardised questionnaire regarding seizure history and phenomenology. Living dogs were invited to a detailed clinical evaluation. Litters more than five years of age, or where epilepsy was present in all offspring before the age of five, were included in the calculations of inheritance. results: Out of 199 family members, 66 dogs suffered from epilepsy. The prevalence of epilepsy in the family was 33%. Fifty-five dogs experienced focal seizures with or without secondary generalisation, while four dogs experienced primary generalised seizures. In seven dogs, seizures could not be classified. The mode of inheritance of epilepsy was simple Mendelian. This study identified that the Belgian shepherd suffers from genetically transmitted focal epilepsy. The seizure phenomenology expressed by family members have a strong resemblance to what has been reported for familial partial (focal) epilepsy in humans with variable foci with suggestion of linkage to chromosome 2 and chromosome 22q12.

  5. Bronchiolitis management by the Belgian paediatrician: discrepancies between evidence-based medicine and practice.

    Science.gov (United States)

    de Bilderling, G; Bodart, E

    2003-01-01

    There is no therapy with proven effect on bronchiolitis outcome. This leads to large variations in its management between different countries. In order to evaluate how this disease was managed in our country, a questionnaire was sent to all Belgian paediatricians. With a response rate above 40% of active paediatricians, we found that bronchodilators (74.7% vs. 77.2%), physiotherapy (76.2% vs. 85.6%) and antibiotics (63.8% vs. 74.4%) were still largely prescribed in in- and outpatient settings respectively, corticosteroids (orally or intravenously) being prescribed more often in hospitals (54.3% vs. 17.0%). There were also some variations in admission criteria (minimal age 2 months (75%) to 6 months (8.2%), lower limit for oxygen saturation: 90% (21.5%) to 95% (26.5%)) and 1/3 of the respondents did not use pulse oxymetry to evaluate hypoxaemia in infants with bronchiolitis. Logistic regression analyses allowed us to identify patterns of prescription based on age, type and level of activity and language. Many therapies with no proven effect are still used by Belgian paediatricians to treat children with bronchiolitis. Based on these results, we believe that publishing national guidelines will allow a reduction in the cost associated with this disease.

  6. Caracterização da qualidade de vida segundo o estado menopausal entre mulheres da Região Sul do Brasil Characterization of the quality of life by menopausal status among women in the South region of Brazil

    Directory of Open Access Journals (Sweden)

    Dino Roberto Soares De Lorenzi

    2009-12-01

    Full Text Available OBJETIVOS: caracterizar a qualidade de vida de mulheres climatéricas residentes na Região Sul segundo o estado menopausal delas. MÉTODOS: foram entrevistadas 236 mulheres com idades entre 40 e 65 anos, durante feira de saúde realizada em cidade do Sul do Brasil, em março de 2005. Na avaliação da qualidade de vida, utilizou-se a versão brasileira do instrumento Menopause Rating Scale. RESULTADOS: das entrevistadas, 133 eram pré-menopáusicas e 103 pós-menopáusicas. As primeiras referiram sintomas climatéricos moderados e severos em 37,6% e 24,0%, respectivamente, enquanto as mulheres pós-menopáusicas, relataram sintomas moderados e severos em 36,9% e 39,4% dos casos, respectivamente. Os escores globais de qualidade de vida não mostraram diferenças entre os grupos estudados (p=0,12, ainda que o grupo pré-menopáusico tenha referido mais sintomas psicológicos (p=0,05 e o pós-menopáusico mais sintomas somato-vegetativos (pOBJECTIVES: to characterize the quality of life of climacteric women residing in the South region by menopausal status. METHODS: two hundred and thirty-six women aged between 40 and 65 were interviewed during a health fair held in March 2005 in a city in the South of Brazil. Their quality of life was assessed using the Brazilian version of the Menopause Rating Scale. RESULTS: of those interviewed, 133 were pre-menopausal and 103 post-menopausal. Moderate and severe climacteric symptoms were reported by 37.6% and 24.0% of the former, respectively, while 36.9% and 39.4% of the post-menopausal women reported moderate and severe symptoms, respectively. There were no differences between the two groups studied in terms of overall scores on the quality of life scale (p=0.12, although the pre-menopausal group reported more psychological symptoms (p=0.05 and the post-menopausal group more somatic-vegetative (p<0.01 and urinogenital (p=0.01 symptoms. CONCLUSIONS: quality of life was not influenced by menopausal status

  7. [Association between the 5-HTTLPR Polymorphism of Serotonin Transporter Gene and EEG in Young and Postmenopausal Women].

    Science.gov (United States)

    VolF, N V; Belousova, L V; Kulikov, A V

    2015-01-01

    Effect of ovarian steroids on serotonin neurotransmission suggests that the modulating effect of polymorphisms of the serotonin transporter gene on brain activity in women may change with age related changes in hormonal status. Objective of the study was to identify relationships between 5-HTTLPR polymorphism of the serotonin transporter gene and characteristics of baseline EEG in healthy young women (19-35 years, N = 85) and in women in post menopause (55-80 years, N = 44). It was shown that in S'/S'(SA/SA, SA/LG) and L'/L' (LA/LA) genotypes carriers' women of the older age group had lower delta, alpha 2 and alpha 3 band power than the young. In older women genetic differences in the power of these rhythms were due to lower values in carriers of S'/S' and L'/L' compared with S'/L' genotype. S'/L' genotype was characterized by higher beta 1 rhythm power in elderly compared with young women. These results demonstrate the difference in the neurophysiological mechanisms of age-related changes in brain activity which are associated with the polymorphism of 5-HTTLPR.

  8. Association of SLC2A9 genotype with phenotypic variability of serum urate in pre-menopausal women

    Directory of Open Access Journals (Sweden)

    Ruth eTopless

    2015-10-01

    Full Text Available The SLC2A9 gene, that encodes a renal uric acid reuptake transporter, has genetic variants that explain ~3% of variance in urate levels. There are previous reports of non-additive interaction between SLC2A9 genotype and environmental factors which influence urate control. Therefore our aim was to further investigate the general phenomenon that such non-additive interactions contribute to genotype-specific association with variance at SLC2A9. Data from 14135 European individuals were used in this analysis. The measure of variance was derived from a ranked inverse normal transformation of residuals obtained by regressing known urate-influencing factors (sex, age and BMI against urate. Variant rs6449173 showed the most significant effect on serum urate variance at SLC2A9 (P = 7.9x10-14, which was maintained after accounting for the effect on average serum urate levels (P=0.022. Noting the stronger effect in a sub-cohort that consisted of pre-menopausal women and younger men, the participants were stratified into males and pre-menopausal and post-menopausal women. This revealed a strong effect on variance in pre-menopausal women (P=3.7x10-5 with a weak effect in post-menopausal women (P=0.032 and no effect in men (P=0.22. The T-allele of rs6449173, which associates with increased urate levels, was associated with the greater variance in urate. There was a non-additive interaction between rs6449173 genotype and female gender in control of serum urate levels that was driven by a greater increase in urate levels associated with the T-allele in women. Female hormones, and/or other factors they influence or are associated with (such as iron levels, temperature, testosterone interact with SLC2A9 genotype in women to determine urate levels. The association of SLC2A9 with greater variance in pre-menopausal women may reflect the cyclical changes resulting from menstruation.

  9. Musculoskeletal pain among women of menopausal age in Puebla, Mexico.

    Science.gov (United States)

    Sievert, Lynnette Leidy; Goode-Null, Susan K

    2005-06-01

    Worldwide, complaints of musculoskeletal pain are more frequent than complaints of hot flashes amongst women of menopausal age. The purpose of this study was to examine musculoskeletal pain among women of menopausal age in the city of Puebla, Mexico. An opportunity sample was recruited from public parks and markets, with representation from all social classes (n=755). Mean age was 50.1 years, and the majority were employed as saleswomen in small businesses. Symptom frequencies were collected by open-ended interviews and with a structured symptom list that queried symptom experience during the two weeks prior to interview. In response to open-ended questions, "dolores de huesos" (bone pain) was volunteered by 47% of respondents as a symptom associated with menopause, second only to hot flashes (53%). From the structured symptom list, 55.8% and 55.6% reported back pain and joint stiffness during the two weeks prior to interview. Women with back pain and joint stiffness were less likely to report being active during their leisure time (p<.01). The results of backwards stepwise logistic regressions indicate that women with back pain were more likely to be older, with less education, a higher BMI, and ate less meat. Women with joint pain were more likely to be post-menopausal, with less education, more children, a higher BMI, and were likely to drink milk and coffee more than once/week but less than once/day. While menopause is not necessarily a risk factor for musculoskeletal pain, it is important to recognize the pervasiveness of this complaint among women of menopausal age.

  10. Association between Smoking and Health Outcomes in Postmenopausal Women Living with Multiple Sclerosis

    Directory of Open Access Journals (Sweden)

    Rachel Jawahar

    2014-01-01

    Full Text Available Background. In multiple sclerosis (MS, symptom management and improved health-related quality of life (HrQOL may be modified by smoking. Objective. To evaluate the extent to which smoking is associated with worsened health outcomes and HrQOL for postmenopausal women with MS. Methods. We identified 251 Women’s Health Initiative Observational Study participants with a self-reported MS diagnosis. Using a linear model, we estimated changes from baseline to 3 years for activities of daily living, total metabolic equivalent tasks (MET hours per week, mental and physical component scales (MCS, PCS of the SF-36, and menopausal symptoms adjusting for years since menopause and other confounders. Results. Nine percent were current and 50% past smokers. Age at smoking initiation was associated with significant changes in MCS during menopause. PCS scores were unchanged. While women who had ever smoked experienced an increase in physical activity during menopause, the physical activity levels of women who never smoked declined. Residual confounding may explain this finding. Smoking was not associated with change in menopausal symptoms during the 3-year follow-up. Conclusion. Smoking was not associated with health outcomes among post-menopausal women with MS.

  11. Circadian as well as circannual rhythms of circulating aldosterone have decreased amplitude in aging women.

    Science.gov (United States)

    Cugini, P; Scavo, D; Centanni, M; Halberg, F; Haus, E; Lakatua, D; Schramm, A; Pusch, H J; Franke, H; Kawasaky, T

    1983-02-01

    Age differences in the characteristics of the circadian rhythm in circulating radioimmunoassayable aldosterone were studied on nine 20 to 26 year-old and ten 70 to 78 year-old women and ten 23 to 26 year old and ten 70 to 80 year old men in Würzburg, West Germany. These diurnally active-nocturnally resting subjects were sampled every 3 hours for 15 hours. A classical analysis of variance and a multivariate analysis of rhythm characteristics revealed major effects of age exerted on the circadian aldosterone amplitude in women (p = 0.003) but not in concomitantly sampled men. These observations complement the study of circadian and circannual rhythms in 8 young adults (15-21 years), 10 mature adults (29-36 years) and 10 post-menopausal (44-59 years) North American women, sampled at 100 minute intervals for 24 hours, once in each season, and document that the adrenocortical aldosterone-producing system remains rhythmic with at least two frequencies up to the late decades of human life, although in women it may be characterized by a reduction in the extent of spectral change after 70 years of age.

  12. Relationship between metabolic syndrome and its components with bone densitometry in postmenopausal women.

    Science.gov (United States)

    Abbasi, Mahnaz; Farzam, Seyed Amir; Mamaghani, Zahra; Yazdi, Zohreh

    2017-11-01

    Prevention of osteoporosis and bone fracture and the relationship between metabolic syndrome and bone density are controversial issues. The aim of this study was to evaluate the association between metabolic syndrome and its components with bone mineral density in post menopausal women referred for bone mineral density (BMD) test. A total of 143 postmenopausal women with at least one year of menopause experience participated in this cross-sectional study. Demographic and anthropometric characteristics for all participants were collected. Also, biochemical parameters including fasting blood sugar, Cholesterol (HDL and LDL), triglyceride were measured. Association between the components of metabolic syndrome and bone densitometry were analyzed by statistical methods. In this study, 72% of participants did not have metabolic syndrome. Among them, 43.4% and 28.7% had osteoporosis and normal density, respectively. Of remaining participants with metabolic syndrome, 12.6% and 15.4% had osteoporosis and normal density, respectively. Among the metabolic syndrome components, waist circumference, HDL cholesterol, and waist to hip ratio were significantly associated with bone mass (Pmetabolic syndrome did not have significant differences than women without metabolic syndrome in terms of lumbar and femoral neck density (P>0.05). Results from this study showed that metabolic syndrome and its components did not induce bone mass loss. The discrepancies of the studies in this area call for more large scale studies in population so as to prevent women problems in this area. Copyright © 2016 Diabetes India. Published by Elsevier Ltd. All rights reserved.

  13. Association of LRP5 gene polymorphism with type 2 diabetes mellitus and osteoporosis in postmenopausal women.

    Science.gov (United States)

    Xuan, Miao; Wang, Yonglan; Wang, Wenxing; Yang, Jun; Li, Ying; Zhang, Xiuzhen

    2014-01-01

    This study was to explore the association of low-density lipoprotein receptor related protein 5 (LRP5) gene polymorphism with bone mineral density (BMD), bone turnover markers and glycometabolism in postmenopausal women with type 2 diabetes mellitus (T2DM) and/or osteoporosis (OP) in Shanghai. 354 unrelated Han Chinese post-menopausal women were recruited from Shanghai and divided into 4 groups: OP group (n=90), T2DM group (n=96), T2DM + OP group (n=90) and control group (n=78). The LRP5 genotypes were determined by DNA sequencing. The BMD was measured by dual-energy X-ray absorptiometry. The bone transformation indicators and glycometabolism index (HbA1c and Fasting insulin) were also detected. The association of LRP5 polymorphism with BMD, bone turnover markers and glycometabolism was evaluated. Result showed that, In OP group, the BMD of L2-4 was higher in patients with rs3736228 CC genotype than those with CT/TT genotypes (P0.05). Thus, LRP5 gene is an impressionable gene in postmenopausal women with OP in Shanghai. T2DM patients have a high BMD when compared with controls, which may be related to BMI and FINS. LRP5 genotype is not an impressionable gene in postmenopausal women with T2DM in Shanghai.

  14. The Human Face of Health News: A Multi-Method Analysis of Sourcing Practices in Health-Related News in Belgian Magazines.

    Science.gov (United States)

    De Dobbelaer, Rebeca; Van Leuven, Sarah; Raeymaeckers, Karin

    2018-05-01

    Health journalists are central gatekeepers who select, frame, and communicate health news to a broad audience, but the selection and content of health news are also influenced by the sources journalists, rely on (Hinnant, Len-Rios, & Oh, 2012). In this paper, we examine whether the traditional elitist sourcing practices (e.g., research institutions, government) are still important in a digitalized news environment where bottom-up non-elite actors (e.g., patients, civil society organizations) can act as producers (Bruns, 2003). Our main goal, therefore, is to detect whether sourcing practices in health journalism can be linked with strategies of empowerment. We use a multi-method approach combining quantitative and qualitative research methods. First, two content analyses are developed to examine health-related news in Belgian magazines (popular weeklies, health magazines, general interest magazines, and women's magazines). The analyses highlight sourcing practices as visible in the texts and give an overview of the different stakeholders represented as sources. In the first wave, the content analysis includes 1047 health-related news items in 19 different Belgian magazines (March-June 2013). In the second wave, a smaller sample of 202 health-related items in 10 magazines was studied for follow-up reasons (February 2015). Second, to contextualize the findings of the quantitative analysis, we interviewed 16 health journalists and editors-in-chief. The results illustrate that journalists consider patients and blogs as relevant sources for health news; nonetheless, elitist sourcing practices still prevail at the cost of bottom-up communication. However, the in-depth interviews demonstrate that journalists increasingly consult patients and civil society actors to give health issues a more "human" face. Importantly, the study reveals that this strategy is differently applied by the various types of magazines. While popular weeklies and women's magazines give a voice to

  15. Correlation between Reproductive Hormonal Level and Osteoporosis among Women in Mongolia.

    Science.gov (United States)

    Lkhagvasuren, Unentsatsral; Jav, Sarantuya; Zagdsuren, Battogtokh

    2015-01-01

    Postmenopausal osteoporosis is the most common bone metabolic disease associated with low bone mineral density (BMD) and osteopathic fragility fractures, which can lead to significant morbidity. The objective of this study was to investigate the relationship between serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2) levels and bone mineral density (BMD) across the stages of menopause in Mongolian women. Two hundred sixty participants aged 50.1±4.4 years were enrolled in the study. Blood samples were obtained from each participant and analyzed using ELISA. Data were first stratified and analyzed by bone mineral density status (osteoporotic, osteopenic, and normal) and then by menopause status. Between group differences were analyzed using t-tests, and correlations were assessed using the Spearman rank order test, with Bonferonni correction. The data were analyzed using Statistical Package Statistical Software version 20.0 (SPSS Inc., Chicago, IL). Significance was set at p <0.05. The mean menopausal age was 48.4±3.4, which is comparable to the Mongolian population mean menopausal age. The mean serum estradiol level in the normal BMD group was 18.3±13.1 pg/ml and 15.8±10.7 pg/ml in the osteoporotic group. The mean serum FSH in the normal BMD group was 54.5±44.1 pg/ml and 81.3±34.2 pg/ml in the osteoporotic group. The mean serum LH level in the normal BMD group was 53.1±41.2 and 75.1±26.1 pg/ml in the osteoporotic group. The mean T and Z score were lower in the osteoporotic group. FSH and LH levels significantly differed across menopause stages in that those who were post-menopausal had higher levels compared to those who were pre- or peri-menopausal. Both hormones, FSH and LH, showed weak negative correlations with BMD level, but not E2. There were significant negative correlations between FSH and Speed of Sound (SOS) (r=-0.16; p<0.01), and between osteoporosis with age (r=-0.30, p<0.05) and number of childbirths (r=-0.14 p

  16. Factors with regard to computerisation of the Dutch and the Belgian national general practitioner sentinel networks: a comparative analysis.

    NARCIS (Netherlands)

    Schweikardt, C.; Casteren, V. van; Verheij, R.A.; Coppieters, Y.

    2013-01-01

    Background: A general practitioner (GP) sentinel network observes a sample of the population by supplying reports on the incidence and epidemiological characteristics of specific diseases and on procedures in primary health care. In the 1970s, the Dutch and the Belgian national GP sentinel networks

  17. Comparing landscape evolution models with quantitative field data at the millennial time scale in the Belgian loess belt

    NARCIS (Netherlands)

    Temme, A.J.A.M.; Peeters, I.; Buis, E.; Veldkamp, A.; Govers, G.

    2011-01-01

    This study compares three landscape evolution models and their ability to correctly simulate measured 2500¿year landscape evolution in two small catchments in the Belgian loess belt. WATEM LT and LAPSUS both model tillage and water erosion and deposition and have detachment-limited descriptions for

  18. The Belgian Minister of Economy, Energy, Foreign Trade and Science Policy, Marc Verwilghen, with CERN's Director-General, Robert Aymar.

    CERN Multimedia

    Michel Blanc

    2005-01-01

    Marc Verwilghen, Belgian Minister of Economy, Energy, Foreign Trade and Science Policy, came to CERN on 8 April 2005, where he visited the CMS assembly hall and underground cavern, as well as the hall where the LHC superconducting magnets are being tested.

  19. In search of the creation of news frames in Flemish newspapers: The case of the Belgian ‘Syria warriors’

    NARCIS (Netherlands)

    Boesman, J.L.J.; Berbers, A.; d'Haenens, L.; Van Gorp, B.

    2014-01-01

    This paper investigates the framing construction of Flemish newspaper journalists regarding the so-called ‘Syria-warriors’. When the Syrian conflict developed, the rebels against the Assad regim were joined by young muslims from Western European countries. Figures of the number of Belgian fighters

  20. Predictors of physical activity at 12 month follow-up after a supervised exercise intervention in postmenopausal women.

    Science.gov (United States)

    Aparicio-Ting, Fabiola E; Farris, Megan; Courneya, Kerry S; Schiller, Ashley; Friedenreich, Christine M

    2015-05-05

    Few studies have examined recreational physical activity (RPA) after participating in a structured exercise intervention. More specifically, little is known about the long-term effects of exercise interventions in post-menopausal women. This study had two objectives: 1) To compare RPA in postmenopausal women in the exercise group and the control group 12 months after the end of the Alberta Physical Activity and Breast Cancer Prevention (ALPHA) Trial; and 2) To apply the Theory of Planned Behaviour (TPB) to identify predictors of RPA 12 months post-intervention among women in the exercise group. Self-reported RPA 12-months post-intervention from a validated questionnaire was used to estimate RPA levels for control group (118/160, 74% response) and exercise group participants (126/160, 79% response). Bivariate analysis was used to compare RPA between exercise and control group participants and to identify TPB variables for multivariate analysis. Logistic regression was applied to TPB data collected from self- administered questionnaires at end of trial by exercise group participants (126/160, 79% response) to identify predictors of long-term RPA. At 12 months post-intervention, 62% of women in the exercise group were active compared to 58% of controls (p = 0.52). Of the TPB constructs examined, self-efficacy (OR =2.98 (1.08-8.20)) and behavioural beliefs (OR = 1.46 (1.03-2.06)) were identified as predictors of RPA for exercise group participants. Levels of RPA in the exercise and control groups were comparable 12 months post intervention, indicating that participation in the ALPHA trial was associated with increased physical activity in previously inactive women, regardless of randomization into either the exercise group or in the control group. Exercise interventions that promote self-efficacy and positive behavioural beliefs have the potential to have long-term impacts on physical activity behaviour, although further research is needed to examine additional

  1. DHEA, important source of sex steroids in men and even more in women.

    Science.gov (United States)

    Labrie, Fernand

    2010-01-01

    A major achievement from 500 million years of evolution is the establishment of a high secretion rate of dehydroepiandrosterone (DHEA) by the human adrenal glands coupled with the indroduction of menopause which stops secretion of estrogens by the ovary. Cessation of estrogen secretion at menopause eliminates the risks of endometrial hyperplasia and cancer which would result from non-opposed estrogen stimulation during the post-menopausal years. In fact, from the time of menopause, DHEA becomes the exclusive and tissue-specific source of sex steroids for all tissues except the uterus. Intracrinology, a term coined in 1988, describes the local formation, action and inactivation of sex steroids from the inactive sex steroid precursor DHEA. Over the past 25 years most, if not all, the genes encoding the human steroidogenic and steroid-inactivating enzymes have been cloned and sequenced and their enzymatic activity characterized. The problem with DHEA, however, is that its secretion decreases from the age of 30 years and is already decreased, on average, by 60% at time of menopause. In addition, there is a large variability in the circulating levels of DHEA with some post-menopausal women having barely detectable serum concentrations of the steroid while others have normal values. Since there is no feedback mechanism controlling DHEA secretion within 'normal' values, women with low DHEA will remain with such a deficit of sex steroids for their remaining lifetime. Since there is no other significant source of sex steroids after menopause, one can reasonably believe that low DHEA is involved, in association with the aging process, in a series of medical problems classically associated with post-menopause, namely osteoporosis, muscle loss, vaginal atrophy, fat accumulation, hot flashes, skin atrophy, type 2 diabetes, memory loss, cognition loss and possibly Alzheimer's disease. A recent randomized, placebo-controlled study has shown that all the signs and symptoms of

  2. RISCOM Applied to the Belgian Partnership Model: More and Deeper Levels

    Energy Technology Data Exchange (ETDEWEB)

    Bombaerts, Gunter; Bovy, Michel; Laes, Erik [SCKCEN, Mol (Belgium). PISA

    2006-09-15

    Technology participation is not a new concept. It has been applied in different settings in different countries. In this article, we report a comparing analysis of the RISCOM model in Sweden and the Belgian partnership model for low and intermediate short-lived nuclear waste. After a brief description of the partnerships and the RISCOM model, we apply the latter to the first and come to recommendations for the partnership model. The strength of the partnership approach is at the community level. In one of the villages, up to one percent of the population was motivated to discuss at least once a month for four years the nuts and bolts of the repository concept. The stress on the community level and the lack of a guardian includes a weakness as well. First of all, if communities come into competition, the inter-community discussions can start resembling local politics and can become less transparent. Local actors are concerned actors but actors at the national level are concerned as well. The local decisions influence how the waste will be transported. The local decisions also determine an extra cost of electricity. We therefore recommend a broad (in terms of territory) public debate on the participation experiments preceding and concluding the local participation process in which this local process maintains an important position. The conclusions of our comparative analysis are: (1) The guardian of the process at the national level is missing. Since the Belgian nuclear regulator plays a controlling role after the process, we recommend a technology assessment institute at the federal level. (2) We state that stretching in the partnership model can happen more profoundly and recommend a 'counter institute' at the European level. The role of non-participative actors should be valued. (3) Recursion levels can be taken as a point of departure for discussion about the problem framing. If people accept them, there is no problem. If people clearly mention issues

  3. Medical Orders: Catholic and Protestant Missionary Medicine in the Belgian Congo 1880-1940

    Directory of Open Access Journals (Sweden)

    Sokhieng Au

    2017-03-01

    Full Text Available The history of religious missions and the provisioning of western medical care in the region that was known as the Congo Free State and later the Belgian Congo reveals the complicated dynamics between competing religious missions vis à vis the Belgian colonial state. This essay highlights divisions between identities and purposes of different religious groups in medical care provisioning, focusing on the divide between the Catholic and Protestant churches. Because most Protestant missions in the Congo were American or British, the medical care provided by the Protestant church was outside of, and sometimes at odds with, the Belgian colonial state until the 1920s. In contrast, the Catholic Church served in an auxiliary role in the colonial state’s medical infrastructure. This was not an ideal situation, leading Catholic leaders to attempt to rework the church’s role in medical provisioning. Ultimately, mission, medicine, and empire were not always comfortable bedfellows. Medische Orders: katholieke en protestantse missiegeneeskunde in de Belgische Congo 1880-1940De geschiedenis van de religieuze missies en het voorzien in westerse medische gezondheidszorg in de Congo Vrijstaat – later de Belgische Congo – onthult de ingewikkelde dynamiek tussen de concurrerende religieuze missies vis à vis de Belgische koloniale staat. Dit artikel belicht verschillende religieuze groepen die medische zorg verleenden in deze regio en hun verdeeldheid inzake identiteiten en doelen. Hierbij wordt vooral gefocust op de tweedracht tussen de katholieke en protestantse kerk. Omdat de meeste protestantse missies die in de Congo gevestigd waren uit Amerika of Engeland kwamen, werd de medische zorg die zij verstrekten vaak buiten de Belgische koloniale staat om geleverd en leefden staat en protestantse kerk tot in de jaren 1920 soms op gespannen voet met elkaar. Dit staat in sterk contrast tot de katholieke kerk die wat betreft medische infrastructuur juist een

  4. RISCOM Applied to the Belgian Partnership Model: More and Deeper Levels

    International Nuclear Information System (INIS)

    Bombaerts, Gunter; Bovy, Michel; Laes, Erik

    2006-01-01

    Technology participation is not a new concept. It has been applied in different settings in different countries. In this article, we report a comparing analysis of the RISCOM model in Sweden and the Belgian partnership model for low and intermediate short-lived nuclear waste. After a brief description of the partnerships and the RISCOM model, we apply the latter to the first and come to recommendations for the partnership model. The strength of the partnership approach is at the community level. In one of the villages, up to one percent of the population was motivated to discuss at least once a month for four years the nuts and bolts of the repository concept. The stress on the community level and the lack of a guardian includes a weakness as well. First of all, if communities come into competition, the inter-community discussions can start resembling local politics and can become less transparent. Local actors are concerned actors but actors at the national level are concerned as well. The local decisions influence how the waste will be transported. The local decisions also determine an extra cost of electricity. We therefore recommend a broad (in terms of territory) public debate on the participation experiments preceding and concluding the local participation process in which this local process maintains an important position. The conclusions of our comparative analysis are: (1) The guardian of the process at the national level is missing. Since the Belgian nuclear regulator plays a controlling role after the process, we recommend a technology assessment institute at the federal level. (2) We state that stretching in the partnership model can happen more profoundly and recommend a 'counter institute' at the European level. The role of non-participative actors should be valued. (3) Recursion levels can be taken as a point of departure for discussion about the problem framing. If people accept them, there is no problem. If people clearly mention issues that are

  5. A federal audit of the Belgian radiotherapy departments in breast cancer treatment

    International Nuclear Information System (INIS)

    Houtte, Paul van; Bourgois, Nicolas; Renard, Francoise; Huget, Philippe; D'hoore, William; Scalliet, Pierre

    2007-01-01

    Background: The Belgian Federal College of Radiotherapy carried out an external audit of breast cancer patient documentation in the 26 Belgian radiotherapy centres. The objective was to assess compliance with the recommendations regarding minimal requirements for documentation of radiotherapy prescription and administration. All centres volunteered to take part in this audit. Methods: Two experienced radiation oncologists site-visited the departments over a 6 month period (Sept. 2003-Feb. 2004), with a list of items to be verified, including details on the surgery, the pathological report, details on systemic treatments, details on the radiotherapy prescription (and consistency with therapeutic guidelines) and delay surgery/radiotherapy. Findings: Three hundred and eighty-nine patients files were reviewed, for a total of 399 breast cancers (10 patients with bilateral cancer). Mean age was 57.8 y (range 29-96). Breast conservative surgery (BCS) was used in 71%; radical mastectomy in 29%. A complete pathological report was present in all files but 2 (99.5% conformity). 5.2% were treated for DCIS, 61.6% for pT1, 28.2% for pT2 and 5% for pT3-4. Data regarding resection margins were specified to be free in 76.2%, tangential in 12% (within 2 mm) and positive for DCIS in 3.8% or invasive cancer in 1.5% (no information, on margins in 6.5%). The pT stage was always specified, and consistent with the macroscopic and microscopic findings. Hormonal receptors were routinely assessed (94.7%), as well as Her2neu (87.4%). Axillary surgery was carried out in 92%, either by sentinel node biopsy or by complete clearance, in which case the median number of nodes analysed was 12 for all centres together (7-17). All radiotherapy prescriptions were in line with evidence-based standards of therapy (i.e., irradiation of breast after BCS or after mamectomy (in case of pN+), but one. The mean delay between surgery and radiotherapy was 5.5 weeks (SD 11days). Conclusion: There was a high

  6. [Diagnostic yield of video capsule endoscopy in premenopausal women with iron-deficiency anemia].

    Science.gov (United States)

    Garrido Durán, Carmen; Iyo Miyashiro, Eduardo; Páez Cumpa, Claudia; Khorrami Minaei, Sam; Erimeiku Barahona, Alicia; Llompart Rigo, Alfredo

    2015-01-01

    Clinical practice guidelines recommend video capsule endoscopy (VCE) studies in patients with iron-deficiency anemia (IDA) after conventional upper and lower endoscopies but there is a need for studies demonstrating the diagnostic yield, clinical impact, and cost in some patient subgroups. 1.To determine the diagnostic yield of VCE in premenopausal women with IDA compared with that in men and postmenopausal women. 2. To identify the presence of VCE predictors in premenopausal women. 3. To estimate the cost-clinical impact relationship associated with VCE in this indication. We retrospectively analyzed 408 patients who underwent VCE. Patients with IDA were enrolled (premenopausal, postmenopausal women, and men), with previous normal work-up by conventional endoscopies. A total of 249 patients were enrolled: 131 women (52.6%), of which 51 were premenopausal and 80 were post-menopausal, and 118 men. The mean age was 60.7±16 years. The diagnostic yield of VCE for the diagnosis of IDA was 44.6% (95% CI 39.9 - 50.8). Diagnostic yield was 50.8% vs 38.9% in men vs women (p=0.05) and was 55% vs 13.7% in postmenopausal vs premenopausal women (p<0.001). No predictors of small bowel lesions were found in premenopausal women. The most common findings in the postmenopausal group were angioectasias (70.5%) and erosions (57.1%) in the premenopausal group. The cost in premenopausal women was 44.727€ and 86.3% of the procedures had no clinical impact. The diagnostic yield of VCE is low in the etiological study of IDA in premenopausal women and there is no cost-effectiveness in relation to clinical impact. No predictors of small bowel lesions were found in this group. Copyright © 2015 Elsevier España, S.L.U. and AEEH y AEG. All rights reserved.

  7. Microstructural properties of trabecular bone autografts: comparison of men and women with and without osteoporosis.

    Science.gov (United States)

    Xie, Fen; Zhou, Bin; Wang, Jian; Liu, Tang; Wu, Xiyu; Fang, Rui; Kang, Yijun; Dai, Ruchun

    2018-03-05

    The microstructure of autologous bone grafts from men over 50 years old and postmenopausal women undergoing spinal fusion were evaluated using micro-CT. We demonstrated postmenopausal women, especially those with osteoporosis (OP) presented more serious microarchitectural deterioration of bone grafts. This study was undertaken to determine microstructural properties of cancellous bone used as autologous bone grafts from osteoporosis patients undergoing lumbar fusion by comparing microstructural indices to controls. Cancellous bone specimens from spinous processes were obtained from 41 postmenopausal women (osteoporosis women, n = 19; controls, n = 22) and 26 men over 50 years old (osteoporosis men, n = 8; controls, n = 18) during lumbar fusion surgery. The microstructural parameters were measured using micro-CT. Significant difference in bone volume fraction (BV/TV), specific bone surface (BS/BV), trabecular thickness (Tb.Th), and structure model index (SMI) value existed between postmenopausal women with OP and controls. Significant difference in trabecular number (Tb.N) existed between men over 50 years old with OP and controls. Postmenopausal women exhibited lower BV/TV, Tb.Th, and higher SMI value than men over 50 years old. Postmenopausal women with OP exhibited lower BV/TV, Tb.Th, and higher BS/BV than men over 50 years old with OP. Post-menopausal women and older men with OP have worse bone quality in autografts than non-osteoporotic men and women. Postmenopausal women with OP presented serious microarchitectural deterioration in older population.

  8. Sustainability of Global and Local Food Value Chains: An Empirical Comparison of Peruvian and Belgian Asparagus

    Directory of Open Access Journals (Sweden)

    Jana Schwarz

    2016-04-01

    Full Text Available The sustainability of food value chains is an increasing concern for consumers, food companies and policy-makers. Global food chains are often perceived to be less sustainable than local food chains. Yet, thorough food chain analyses and comparisons of different food chains across sustainability dimensions are rare. In this article we analyze the local Belgian and global Peruvian asparagus value chains and explore their sustainability performance. A range of indicators linked to environmental, economic and social impacts is calculated to analyze the contribution of the supply chains to economic development, resource use, labor relations, distribution of added value and governance issues. Our findings suggest that none of the two supply chains performs invariably better and that there are trade-offs among and between sustainability dimensions. Whereas the global chain uses water and other inputs more intensively and generates more employment per unit of land and higher yields, the local chain generates more revenue per unit of land.

  9. Qualification of non-destructive examination for belgian nuclear reactor pressure vessel inspection

    International Nuclear Information System (INIS)

    Couplet, D.; Francoise, T.

    2001-01-01

    In Service Inspection (ISI) participates to the assessment of Nuclear Reactor Pressure Vessel Integrity. The performance of Non Destructive Examination (NDE) techniques must be demonstrated according to predefined objectives. The qualification process is essential to trust the reliability of the information provided by NDE. In Belgian Nuclear Power Plants, the qualification was conducted through a collaboration between the vendor and a technical group from the Electricity Utility. The important facts of this qualification will be presented: - the detailed definition of the inspection and qualifications objectives, based on a combination of the ASME code and the European Methodology for Qualification; - the systematic verification of the NDE performance and limitations, for each ISI objective, through an adequate combination of tests on blocks and technical justification; - the continuous improvement of the NDE procedure; - the feedback and the lessons learnt from site experience; - the necessary multi-disciplinary approach (NDE, degradation mechanisms, structural integrity)

  10. Cloning of a vacuolar invertase from Belgian endive leaves (Cichorium intybus).

    Science.gov (United States)

    Van Den Ende, Wim; Michiels, An; Le Roy, Katrien; Van Laere, André

    2002-08-01

    Although a lot of vacuolar invertase (EC 3.2.1.26) cDNAs are available from a diversity of plant species, up to now no sequence information is available on invertases from any dicot fructan-containing species. Therefore, we describe the cloning of vacuolar acid invertase cDNA from etiolated Belgian endive leaves (Cichorium intybus L. var. foliosum cv. Flash), formed throughout the forcing process of the witloof chicory roots. Full-length cDNA was obtained by a combination of RT-PCR, PCR and 5'- and 3' RACE RT-PCR, starting with primers based on conserved amino acid sequences. The cloned chicory acid invertase groups together with vacuolar type invertases and fructan biosynthetic enzymes. A putative role for vacuolar type invertases in fructan synthesizing plants is discussed.

  11. Natural genetic transformation by agrobacterium rhizogenes . Annual flowering in two biennials, belgian endive and carrot

    Science.gov (United States)

    Limami; Sun; Douat; Helgeson; Tepfer

    1998-10-01

    Genetic transformation of Belgian endive (Cichorium intybus) and carrot (Daucus carota) by Agrobacterium rhizogenes resulted in a transformed phenotype, including annual flowering. Back-crossing of transformed (R1) endive plants produced a line that retained annual flowering in the absence of the other traits associated with A. rhizogenes transformation. Annualism was correlated with the segregation of a truncated transferred DNA (T-DNA) insertion. During vegetative growth, carbohydrate reserves accumulated normally in these annuals, and they were properly mobilized prior to anthesis. The effects of individual root-inducing left-hand T-DNA genes on flowering were tested in carrot, in which rolC (root locus) was the primary promoter of annualism and rolD caused extreme dwarfism. We discuss the possible adaptive significance of this attenuation of the phenotypic effects of root-inducing left-hand T-DNA.

  12. Health effects[1997 Scientific Report of the Belgian Nuclear Research Centre

    Energy Technology Data Exchange (ETDEWEB)

    Mahieu, L.

    1998-07-01

    The objectives of the research in the field of epidemiology , performed at the Belgian Nuclear Research Centre SCK-CEN are (1) to study cancer mortality and morbidity in nuclear workers in Belgium; (2) to document the feasibility of retrospective cohort studies in Belgium; (3) to participate in the IARC study. For radiobiology, the main objectives are: (1) to elucidate the mechanisms of the effects of ionizing radiation on the mammalian embryo during the early phase of its development, (2) to assess the genetic risks of maternal exposure to ionizing radiation, (3) to elucidate the mechanisms by which damage to the brain and mental retardation are caused in man after prenatal irradiation. The main achievements in these domains for 1997 are presented.

  13. Safety culture in a Belgian nuclear research centre from a social science point of view

    International Nuclear Information System (INIS)

    Fucks, I.; Hardeman, F.

    2002-01-01

    This paper is the result of a reflection within the framework of a Ph.D. research at SCK-CEN (Belgian Nuclear Research Centre) in collaboration with the University of Liege. The starting point of the work was the 'safety culture' model presented in the IAEA report 75-INSAG-4. This model is applied to the working organization of the SCK-CEN, also considering the safety culture as an open concept given its multi dimensionality. The methodology is based on three methods: observations, focus groups and interviews. The fieldwork was limited to two main installations: a research reactor, and a dismantling site. The preliminary findings are based on the data resulting from 4 Focus Groups. The most prominent components of a safety culture and the multiplicity of safety cultures in a large organization such as SCK-CEN will be discussed. (author)

  14. 1997 Scientific Report[1997 Scientific Report of the Belgian Nuclear Research Centre

    Energy Technology Data Exchange (ETDEWEB)

    Govaerts, P.

    1998-07-01

    The 1997 Scientific Report of the Belgian Nuclear Research Centre SCK-CEN describes progress achieved in nuclear safety, radioactive waste management, radiation protection and safeguards. In the field of nuclear research, the main projects concern the behaviour of high-burnup and MOX fuel, the embrittlement of reactor pressure vessels, the irradiation-assisted stress corrosion cracking of reactor internals, and irradiation effects on materials of fusion reactors. In the field of radioactive waste management, progress in the following domains is reported: the disposal of high-level radioactive waste and spent fuel in a clay formation, the decommissioning of nuclear installations, the study of alternative waste-processing techniques. For radiation protection and safeguards, the main activities reported on are in the field of site and environmental restoration, emergency planning and response and scientific support to national and international programmes.

  15. Behaviour of the steam generators in the Belgian nuclear power plants

    International Nuclear Information System (INIS)

    Balthazar, J.; Roofthooft, R.; Melsen, C. van

    1981-01-01

    After a brief review of the degradations occurring on tubes of Inconel 600 in steam generators of PWR power stations emphasis is put on the conditioning of the secondary water and more particularly on the condensate treatment in the units of Doel which work on heavily polluted brackish water. The important role of non-destructive testing and eddy-current testing is also pointed out, method developed by Laborelec. The operational experience shows that Belgian stations are nearly not concerned by the degradations mostly found in power stations in other countries which shows the efficiency of the conditioning of the secondary water. On the other hand, other problems have occurred, resulting from: damage caused by foreign objects; fouling of tube before commissioning, cracking of bends and at the limit of the dudgeoning and leaking plugs. (AF)

  16. Piping design and analysis: comparison between the Belgian applications of French and American rules

    International Nuclear Information System (INIS)

    Daoust, Ph.; Geraets, L.H.; Lafaille, J.P.

    1989-01-01

    In the process of a feasibility study of a new nuclear power plant in Belgium, the French and American rules for piping design have been compared. The Belgian method rests on the American nuclear set of rules and uses the ASME code. French rules were initially based on the American rules (1978). Subsequent individual development led to a differentiation of the rules. Presently, the mechanical part of the French rules is mainly contained in the RCCP ('Regles de Conception et de Construction relatives aux Procedes') and the RCCM ('Regles de Conception et de Construction des materiels Mecaniques'). This paper compares the piping design rules from a general point of view; examples of applications allow benefits or drawbacks of the use of ASME or RCCM codes to identified. (author)

  17. The Belgian initiative G1000. A feasible model of deliberative cyber democracy

    Directory of Open Access Journals (Sweden)

    Laura Tejedor Fuentes

    2016-11-01

    Full Text Available In 2010, after five hundred days without any stable form of government, a group of Belgian citizens from a wide range of social backgrounds launched a citizenship summit called 'G1000'. The aim of the event was to create citizen involvement in politics by stimulating participants to take part in debates about social issues and by applying innovative techniques of deliberative democracy. In order to verify whether the model mentioned meets the criteria of an “online democratic-deliberative” experiment, this article carried out a quantitative analysis of the G1000 based on the work of Fishkin, Chadwick and Habermas. According to the majority of authors who have contributed to the topic, including the spokesperson and organizer of the event, Vincent Jacquet the results demonstrate that the G1000 summit is, in fact, a genuine democratic-deliberative initiative.

  18. 226Ra, 222Rn AND PERMEABILITY OF BELGIAN SOILS IN RELATION WITH INDOOR RADON RISK.

    Science.gov (United States)

    Licour, C; Tondeur, F; Gerardy, I; Alaoui, N Medaghri; Dubois, N; Perreaux, R; Gerardy, N; Christiaens, D

    2017-11-01

    Knowing the concentration of 226Ra in soil and of 222Rn in soil gas is important for the analysis of indoor radon data and the prediction of radon-prone areas. Except for soil Rn in Ardenne, the data concerning these two radionuclides in Belgian soils are very scarce. In the context of Master theses and international courses, students made 92 measurements of 226Ra in soil samples, 105 of 222Rn in soil gas, and 74 of soil permeability, a significant addition to the existing similar data. The data are analysed in relation with soil texture, geological units and indoor radon risk. There is no clear correlation between radium in soil and indoor radon risk, the most important factor of risk being soil permeability. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  19. Congomania in Academia. Recent Historical Research on the Belgian Colonial Past

    Directory of Open Access Journals (Sweden)

    S.E. Kiangu

    2011-01-01

    Full Text Available The Congo has recently been the subject of much academic research. This article discusses the major trends and developments. It primarily focuses on the Congo crisis of 1960, which was commemorated in 2010 and has been inquired into by many historians, including American, British and Russian ones. A comparison of their conclusions reveals that Flanders has largely come to terms with its colonial past, but that the French-speaking community has a more problematic memory. Belgian academia, by contrast, has left the old controversies about Leopold II and Lumumba behind and embarked on the path of new imperial history. It approaches the Congolese past from new angles and with new paradigms, such as reciprocity, science, exhibition, representation, etc. Congolese academia suffers from the economic problems of the country, but has managed to produce a number of studies, focusing mainly on regions, religion, and resistance. Strikingly, Congolese historians have little criticism of the colonial era.

  20. Predicting mortality and incident immobility in older Belgian men by characteristics related to sarcopenia and frailty

    DEFF Research Database (Denmark)

    Kruse, C; Goemaere, S; De Buyser, S

    2018-01-01

    and bone mineral density scores were the most important predictors. INTRODUCTION: Machine learning principles were used to predict 5-year mortality and 3-year incident severe immobility in a population of older men by frailty and sarcopenia characteristics. METHODS: Using prospective data from 1997 on 264......There is an increasing awareness of sarcopenia in older people. We applied machine learning principles to predict mortality and incident immobility in older Belgian men through sarcopenia and frailty characteristics. Mortality could be predicted with good accuracy. Serum 25-hydroxyvitamin D...... the most important predictors of immobility. Sarcopenia assessed by lean mass estimates was relevant to mortality prediction but not immobility prediction. CONCLUSIONS: Using advanced statistical models and a machine learning approach 5-year mortality can be predicted with good accuracy using a Bayesian...

  1. Self-reported racial discrimination and endothelial reactivity to acute stress in women.

    Science.gov (United States)

    Wagner, Julie A; Tennen, Howard; Finan, Patrick H; Ghuman, Nimrta; Burg, Matthew M

    2013-08-01

    This study investigated the effect of self-reported racial discrimination on endothelial responses to acute laboratory mental stress among post-menopausal women. One-hundred thirteen women (n = 94 self-identified as White and n = 19 self-identified as racial/ethnic minority), 43% with type 2 diabetes, reported lifetime experiences of racial/ethnic discrimination. Repeated assessments of flow-mediated dilation were performed at baseline, immediately after 5 min of mental arithmetic and at 20-min recovery. Both White and racial/ethnic minority women reported lifetime discrimination, with rates significantly higher among minorities. Self-reported lifetime discrimination was associated with attenuated flow-mediated dilation at recovery. Confounding variables, including clinical characteristics, mood, personality traits, other life stressors and general distress, did not better account for the effect of racial discrimination. Neither race/ethnicity nor diabetes status moderated the effect. The perceived stressfulness of the mental arithmetic was not associated with the endothelial response. In conclusion, self-reported lifetime discrimination is associated with attenuated endothelial recovery from acute mental stress. Elucidating the effects of discrimination and the biological mechanisms through which it affects the vasculature may suggest interventions to improve health. Copyright © 2012 John Wiley & Sons, Ltd.

  2. Incidence and risk factors of lower leg fractures in Belgian soccer players.

    Science.gov (United States)

    Vanlommel, Luc; Vanlommel, Jan; Bollars, Peter; Quisquater, Laurent; Van Crombrugge, Kris; Corten, Kristoff; Bellemans, Johan

    2013-12-01

    Soccer is the world's most popular sport and one that is physically demanding and highly competitive. Consequently, the rate of injuries resulting from this sport is only increasing. It is estimated that 2-20% of all such injuries are fractures, one-third of which are located in the lower extremities. The aim of this epidemiological study was to investigate the incidence of lower-leg fractures (LLFs) in Belgian soccer players and determine the possible risk factors that lead to them. All injuries of players associated with the Royal Belgium Football Association (RBFA) were reported and collected in a nationwide registry. We retrospectively compared the incidence rate of and risk factors for LLFs in Belgian soccer players during two seasons, 1999-2000 and 2009-2010. In total, 1600 fractures (3%) were located in the lower leg. After a decade, the number of LLFs remained unchanged. Ankle fractures were the most common (37%), followed by foot and tibia fractures (33% and 22%, respectively). The least common were fibula fractures, which accounted for just 9%. A higher incidence of every type of LLF was observed in older and amateur-level soccer players, when compared with their younger and professional counterparts. Male players experienced more tibia and foot fractures, whereas the incidences of ankle and fibula fractures were comparable with those in female soccer players. The vast majority of fractures occurred during soccer games. Ankle fractures and foot fractures represented two-thirds of all fractures noted in this analysis. Male gender, recreational level and adult age were important risk factors for LLFs. After 10 years, the incidence of LLFs did not decrease. Given the socioeconomic impact of these injuries, improved prevention techniques are required to reduce their incidence, particularly with regard to the frequently occurring ankle and foot fractures in this population. Copyright © 2013 Elsevier Ltd. All rights reserved.

  3. Belgian citizens' and broiler producers' perceptions of broiler chicken welfare in Belgium versus Brazil.

    Science.gov (United States)

    Vanhonacker, F; Tuyttens, F A M; Verbeke, Wim

    2016-07-01

    New EU regulations require more stringent country-of-origin labeling, while imports of broiler meat from non-EU countries are increasing. In light of these trends, we have studied citizens' and producers' perceptions of broiler meat originating from Belgium versus Brazil and their perception of broiler production in Belgium versus Brazil. A particular focus was the association between country of origin and perceived level of animal welfare. We also investigated the perception of scaling-up and outdoor access in terms of perceived level of animal welfare. Cross-sectional survey data was collected among Flemish citizens (n = 541) and broiler producers (n = 114). In accordance with literature on general farm animal welfare, both stakeholder types claimed to allocate great importance to broiler welfare and generally agreed with the Welfare Quality model of broiler welfare. Citizens disagreed with the producers that 1) consumers are not willing to pay more for higher welfare products, 2) that broilers suffer little, 3) that broiler welfare in current Belgian production units is generally non-problematic, 4) that scaling-up production units would not have a positive impact on profitability nor a profoundly negative impact on broiler welfare, and 5) that the impact of providing broilers with outdoor access is negative for consumers, farmers, and broilers. Country of origin had a strong influence on the perception of both broiler production and broiler meat. Belgian citizens, and producers (much more than citizens) considered nearly all aspects related to broiler production and broiler meat to be significantly superior for chicken produced in Belgium compared to Brazil. Further research should focus on how these perceptions influence purchase intentions and production decisions. Future avenues for research are to quantify market opportunities for country-of-origin labeling and to investigate to which extent stakeholders' perceptions correspond with reality. © 2016 Poultry

  4. Overweight, obesity and related non-communicable diseases in Asian Indian girls and women.

    Science.gov (United States)

    Chopra, S M; Misra, A; Gulati, S; Gupta, R

    2013-07-01

    The prevalence of obesity is rising globally and in India. Overweight, obesity and related diseases need to be delineated in Asian Indian women. A literature search was done using key words like 'obesity', 'Asian Indian women', 'body fat distribution', 'type 2 diabetes', 'fertility', 'polycystic ovarian disease', metabolic syndrome', 'cardiovascular disease', 'non-alcoholic fatty liver disease', 'gender', 'sex' and 'prevalence' up to September 2012 in Pubmed and Google Scholar search engines. This review highlights the Asian Indian body composition with regards to obesity and provides a collated perspective of gender-specific prevalence of the co-morbidities. Recent data show that women (range of prevalence of overweight and obesity from different studies 15-61%) have higher prevalence of overweight and obesity as compared with men (range of prevalence of overweight and obesity from different studies 12-54%) in India and that obesity is increasing in the youth. The prevalence of overweight and obesity in both men and women steeply rose in a Punjabi community from Jaipur. Importantly, prevalence of abdominal obesity has been consistently higher in women than in men. The lowest prevalence (6.0%) of type 2 diabetes mellitus in women is reported from South India (rural Andhra Pradesh; 2006) and the highest (14.0%) by the National Urban Diabetes Survey (2001). Although the clustering of cardiovascular disease risk factors was generally high, it increased further in post-menopausal women. There are a number of factors that predispose Indian women to obesity; sedentary behaviour, imbalanced diets, sequential and additive postpartum weight gain and further decrease in physical activity during this period and cultural issues. In view of these data, preventive measures should be specifically targeted to Indian women.

  5. Body fatness and breast cancer risk in women of African ancestry.

    Science.gov (United States)

    Bandera, Elisa V; Chandran, Urmila; Zirpoli, Gary; Gong, Zhihong; McCann, Susan E; Hong, Chi-Chen; Ciupak, Gregory; Pawlish, Karen; Ambrosone, Christine B

    2013-10-14

    Obesity has been shown to be inversely associated with breast cancer risk in premenopausal women, while increasing risk in postmenopausal women. However, the current evidence is largely based on studies in Caucasian populations. Associations in women of African ancestry (AA), who have a higher prevalence of obesity, have been evaluated in few studies and results suggest different effects. We evaluated the impact of body size, body fat distribution, and body composition on breast cancer risk among AA women (978 cases and 958 controls) participating in the Women's Circle of Health Study, a multi-site case-control study in New York City (NYC) and New Jersey (NJ). Cases were newly diagnosed with histologically confirmed ductal carcinoma in situ or invasive breast cancer, age 20-75 yrs. In NYC, cases were recruited through hospitals with the largest referral patterns for AA women and controls through random digit dialing (RDD). In NJ, cases were identified in seven counties in NJ thorough the NJ State Cancer Registry, and controls through RDD and community-based recruitment. During in-person interviews, questionnaires were administered and detailed anthropometric measurements were obtained. Body composition was assessed by bioelectrical impedance analysis. BMI did not have a major impact on pre- or post-menopausal breast cancer, but was significantly associated with reduced risk of ER-/PR- tumors among postmenopausal women (OR: 0.37; 95% CI: 0.15-0.96 for BMI > 30 vs. BMI women were above one, confidence intervals included the null value. Our study suggests that in AA women BMI is generally unrelated to breast cancer. However, higher waist and hip circumferences were associated with increased pre-menopausal breast cancer risk, while general obesity was associated with decreased risk of ER-/PR- tumors. Larger studies are needed to confirm findings and to evaluate the impact of obesity on breast cancer subtypes.

  6. [The relationship of nutritional status, body and mandibular bone mineral density, tooth loss and fracture risk (FRAX) in pre-and postmenopausal women with periodontitis].

    Science.gov (United States)

    Aguilera-Barreiro, de Los Angeles; Dávalos-Vázquez, Karla Fabiola; Jiménez-Méndez, Carolina; Jiménez-Mendoza, Daniel; Olivarez-Padrón, Luis Ángel; Rodríguez-García, Mario Enrique

    2014-06-01

    During menopause there is weight gain and a decrease in bone mineral density (BMD) that has been related with periodontal disease (incidence between 5-30%); therefore, it is essential to assess the risk factors related with anthropometry and BMD. To assess the relationship between body mass index (BMI), skeletal composition, waist circumference, tooth loss, fracture risk, BMD of the spine, hip, femur, and mandible in pre and post-menopausal women with periodontitis. We studied 60 women aged 35-60 years, divided in 4 groups (n = 15): premenopausal women without periodontitis; Experimental group 1: premenopausal women with periodontitis; Experimental group 2: postmenopausal women without periodontitis; and Experimental group 3: postmenopausal women with periodontitis. Periodontitis was diagnosed by means of a computerized digital periodontal probe; BMD of the mandible by means of digital radiograph with X ray conversion, the number of teeth by digital panoramic radiograph. We measured: BMI, skeletal composition, waist circumference, risk fracture by the FRAX questionnaire. The variables with a negative correlation with periodontitis were: weight, BMI, and BMD of the mandible with risk fracture (p fracture risk is associated with low weight and BMI and low BMD of the mandible. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.

  7. Use of Gelatinized Maca (Lepidium Peruvianum) in Early Postmenopausal Women

    Science.gov (United States)

    Meissner, H. O.; Kapczynski, W.; Mscisz, A.; Lutomski, J.

    2005-01-01

    Objective: This double-blind, placebo-corrected clinical pilot study was aimed at assessing the use of hypocotyls of cruciferous Andean plant Maca (Lepidium peruvianum Chacon), in alleviating symptoms of menopausal discomfort experienced by women in early post menopause as measured by profiles of serum hormones: Luteinizing Hormone (LH), Follicle-stimulating Hormone (FSH), Estrogen (E2) and Progesterone (PG) and as assessed by Greene’s Menopausal Index. Design: Study was conducted on 20 Caucasian healthy early-postmenopausal women volunteers during the three months period (Trial I) and on eight women during nine months period (Trial II). Hormone levels were determined in blood with a simultaneous assessment of menopausal index at the start of study, after one month use of placebo, and after two and eight months administration of 2g gelatinized Maca root powder (Maca-GO) in the form of two 500mg hard gel capsules, twice daily. Results: In comparison to placebo, after both, two and eight months administration of Maca-GO capsules to EPMW, level of FSH significantly (PMaca-GO treatment only. There was a significant (PMaca-GO when used in EPMW, depending on the length of use, was acting as a toner of hormonal processes as reflected by decrease in FSH and increased LH secretion, which stimulated production of both ovarian hormones, E2 and PG and resulted in a substantial reduction of menopausal discomfort felt by women participating in the study, with a distinctive placebo effect, thus, fully justifying further, more complex study on effectiveness of Maca-GO as a reliable alternative to HRT program. PMID:23674952

  8. Characterization of patients in the European Forsteo Observational Study (EFOS): postmenopausal women entering teriparatide treatment in a community setting

    DEFF Research Database (Denmark)

    Rajzbaum, Gerald; Jakob, Franz; Karras, Dimitrios

    2007-01-01

    OBJECTIVE: The European Forsteo Observational Study (EFOS) study was primarily designed to assess fracture incidence, degree of pain, health-related quality of life (HRQoL) and compliance in women prescribed teriparatide in a community setting. This report describes the design of the study and ch.......CONCLUSIONS: The post-menopausal women prescribed teriparatide were severely osteoporotic, with a high fracture risk and poor HRQoL, despite previous therapy for osteoporosis. Moderate to severe back pain was very common. Udgivelsesdato: 2007-Dec-20......OBJECTIVE: The European Forsteo Observational Study (EFOS) study was primarily designed to assess fracture incidence, degree of pain, health-related quality of life (HRQoL) and compliance in women prescribed teriparatide in a community setting. This report describes the design of the study...... and characteristics of the patients at entry.METHODS: At entry, 1645 postmenopausal women with a diagnosis of osteoporosis and about to initiate teriparatide treatment were enrolled in eight European countries. Baseline data were collected on demographic characteristics, medical and osteoporosis history, disease...

  9. Attention bias in older women with remitted depression is associated with enhanced amygdala activity and functional connectivity.

    Science.gov (United States)

    Albert, Kimberly; Gau, Violet; Taylor, Warren D; Newhouse, Paul A

    2017-03-01

    Cognitive bias is a common characteristic of major depressive disorder (MDD) and is posited to remain during remission and contribute to recurrence risk. Attention bias may be related to enhanced amygdala activity or altered amygdala functional connectivity in depression. The current study examined attention bias, brain activity for emotional images, and functional connectivity in post-menopausal women with and without a history of major depression. Attention bias for emotionally valenced images was examined in 33 postmenopausal women with (n=12) and without (n=21) a history of major depression using an emotion dot probe task during fMRI. Group differences in amygdala activity and functional connectivity were assessed using fMRI and examined for correlations to attention performance. Women with a history of MDD showed greater attentional bias for negative images and greater activity in brain areas including the amygdala for both positive and negative images (pcorr amygdala activity for negative images was correlated with attention facilitation for emotional images. Women with a history of MDD had significantly greater functional connectivity between the amygdala and hippocampal complex. In all participants amygdala-hippocampal connectivity was positively correlated with attention facilitation for negative images. Small sample with unbalanced groups. These findings provide evidence for negative attentional bias in euthymic, remitted depressed individuals. Activity and functional connectivity in limbic and attention networks may provide a neurobiological basis for continued cognitive bias in remitted depression. Copyright © 2016 Elsevier B.V. All rights reserved.

  10. Quantitative Comparison of Un-Stimulated Whole Saliva Flow Rate Among Menopausal Women and Same Aged Men

    Directory of Open Access Journals (Sweden)

    Ahadian H.

    2010-01-01

    Full Text Available AbstractBackground and Objectives: Menopause can be associated with psycho-somatic changes in oro-facial areas like xerostomia and Burning Mouth Syndrome, although these findings are controversial. The present study sought to compare the Un-stimulated Whole Saliva (UWS flow rate of a group including menopausal & postmenopausal women and same-aged men.Methods: In this cross-sectional analytic-descriptive study 40 menopausal & post-menopausal women (as experimental-group and 40 same-aged men (as control group without any systemic diseases and any drug consumption were divided into 2 groups, xerostomia was evaluated by a questionnaire, and their psychological conditions were assessed with HAD scale. UWS flow rate was measured by the spitting method. Data were analyzed by chi-square, Krusscal Walis and Mann-Whitney tests. Results: Mean of UWS flow rates in experimental group was significantly less than that in control group (P=0.006; no significant difference was found between the two groups regarding psychological condition. Also, menopausal women had significantly greater xerostomia than men (45% vs 15% (P=0.003.Conclusion: Based on this study, xerostomia and reduction in UWS flow rate are sequences of menopause, these findings necessitate the increasing awareness of menopausal & postmenopausal women for controlling the methods of these problems.Keywords: Menopause; Xerostomia; Saliva.

  11. Quantitative Comparison of Un-Stimulated Whole Saliva Flow Rate Among Menopausal Women and Same Aged Men

    Directory of Open Access Journals (Sweden)

    H Ahadian

    2012-05-01

    Full Text Available

    Background and Objectives: Menopause can be associated with psycho-somatic changes in oro-facial areas like xerostomia and Burning Mouth Syndrome, although these findings are controversial. The present study sought to compare the Un-stimulated Whole Saliva (UWS flow rate of a group including menopausal & postmenopausal women and same-aged men.

    Methods: In this cross-sectional analytic-descriptive study 40 menopausal & post-menopausal women (as experimental-group and 40 same-aged men (as control group without any systemic diseases and any drug consumption were divided into 2 groups, xerostomia was evaluated by a questionnaire, and their psychological conditions were assessed with HAD scale. UWS flow rate was measured by the spitting method. Data were analyzed by chi-square, Krusscal Walis and Mann-Whitney tests.

    Results: Mean of UWS flow rates in experimental group was significantly less than that in control group (P=0.006; no significant difference was found between the two groups regarding psychological condition. Also, menopausal women had significantly greater xerostomia than men (45% vs 15% (P=0.003.

    Conclusion: Based on this study, xerostomia and reduction in UWS flow rate are sequences of menopause, these findings necessitate the increasing awareness of menopausal & postmenopausal women for controlling the methods of these problems

  12. Does the financial analysts' usage of non-financial information influence the analysts' forecast accuracy? Some evidence from the Belgian sell-side financial analyst

    OpenAIRE

    ORENS, Raf; LYBAERT, Nadine

    2007-01-01

    This paper examines whether the use of non-financial information by sell-side financial analysts influences the accuracy of analysts' forecasts. The research findings, based on a survey of Belgian financial analysts, suggest that financial analysts who use more forward-looking information and more internal-structure information offer more accurate forecasts. Furthermore, the listed Belgian firms examined in this study have improved their non-financial information reporting over time. However...

  13. Are patterns of bone loss in anorexic and postmenopausal women similar? Preliminary results using high resolution peripheral computed tomography.

    Science.gov (United States)

    Milos, Gabriella; Häuselmann, Hans-Jörg; Krieg, Marc-Antoine; Rüegsegger, Peter; Gallo, Luigi M

    2014-01-01

    This study intended to compare bone density and architecture in three groups of women: young women with anorexia nervosa (AN), an age-matched control group of young women, and healthy late postmenopausal women. Three-dimensional peripheral quantitative high resolution computed-tomography (HR-pQCT) at the ultradistal radius, a technology providing measures of cortical and trabecular bone density and microarchitecture, was performed in the three cohorts. Thirty-six women with AN aged 18-30 years (mean duration of AN: 5.8 years), 83 healthy late postmenopausal women aged 70-81 as well as 30 age-matched healthy young women were assessed. The overall cortical and trabecular bone density (D100), the absolute thickness of the cortical bone (CTh), and the absolute number of trabecules per area (TbN) were significantly lower in AN patients compared with healthy young women. The absolute number of trabecules per area (TbN) in AN and postmenopausal women was similar, but significantly lower than in healthy young women. The comparison between AN patients and post-menopausal women is of interest because the latter reach bone peak mass around the middle of the fertile age span whereas the former usually lose bone before reaching optimal bone density and structure. This study shows that bone mineral density and bone compacta thickness in AN are lower than those in controls but still higher than those in postmenopause. Bone compacta density in AN is similar as in controls. However, bone inner structure in AN is degraded to a similar extent as in postmenopause. This last finding is particularly troubling. © 2013.

  14. [Quality of life and related factors among climacteric women from south Brazil].

    Science.gov (United States)

    de Lorenzi, Dino R S; Saciloto, Bruno; Artico, Graziela R; Fontana, Sabrina K R

    2009-01-01

    This study aimed to evaluate the quality of life in climacteric and associated factor among women from Southeast Brazil. A cross-section study of 506 women aged between 45 and 60 years old attended at a university climacteric clinic from South Brazil from June to October 2002. Hysterectomized women, as well as hormonal therapy or hormonal contraceptive users were excluded. The quality of life was evaluated by the Women's Health Questionnaire (WHQ). Statistical analysis was performed with multiple linear regression analysis. The average of the age among the studied women was 51.3 (+/- 4.5) years old. About 15.4% were premenopausal, 34.4% perimenopausal and 50.2% postmenopausal women. The quality of life showed up deteriorated among the studied women. The factors related with quality of life were: the educational level (p < 0.01), the confirmation of smoking in the last year (p < 0.01), regular physical activity (p < 0.01), the confirmation of previous co-morbidities (p < 0.01) and the menopausal status (p < 0.01). A higher educational level, as well as the confirmation of regular physical activity led to a significant increase on their life quality. Smoking and previous clinical co-morbidities were responsible for the lower scores of quality of life. The pre-menopause was associated with a higher life quality level if compared to peri and post menopause. No differences in relation to the scores of life were identified among the perimenopausal and postmenopausal women. Nevertheless the menopausal status showed up associated to the quality of life, the results of the study pointed out that the climacteric is not just influenced by biological factors, but also by psychosocial and cultural factors.

  15. The Study of Prehistoric Artefacts in National Context: Belgian Archaeologists and the Problem of Ancient Stone Implements

    Directory of Open Access Journals (Sweden)

    Matthew R. Goodrum

    2013-09-01

    Full Text Available During the early nineteenth century European archaeologists were formulating new ideas about the significance of ancient stone artefacts. Some, such as Christian Thomsen in Copenhagen, believed that in Scandinavia, a Stone Age had preceded the Bronze and Iron Ages. In France some excavations had retrieved stone artefacts from deep levels of peat and cave deposits that suggested that these objects were of very great antiquity. While the collection and study of stone artefacts occurred across much of Europe, there were regional variations in their interpretation. Assisted by local institutions and motivated by patriotism, Belgian archaeologists who participated in this research, had much in common with their colleagues elsewhere in Europe, but the nature of local archaeological sites and the ideas of local researchers had an impact on the development and contributions of Belgian prehistoric archaeology.

  16. Towards a PSA harmonization French-Belgian comparison of the level 1 PSA for two similar PWR types

    International Nuclear Information System (INIS)

    Dupuy, P.; Corenwinder, F.; Lanore, J.M.; Gryffroy, D.; Gelder, P. de; Hulsmans, M.

    2002-06-01

    In the framework of the cooperation between French and Belgian regulatory authorities, a PSA (Probabilistic Safety Assessment) comparison exercise has been carried out for several years. This comparison deals with two PSA level 1 studies for internal events, performed for both power and shutdown states: the French PSA of the 900 MWe-series PWR, and the Belgian PSA of the Tihange 1 PWR, which both concern PWRs with a similar Framatome design. The purpose of this paper is to describe the PSA comparison methodology and to present, in a qualitative way, an overview of the insights obtained up to now. It also shows that such an 'a posteriori' benchmark exercise turns out to be a step towards PSA harmonization, and gives more confidence in the results of plant specific PSA when used for applications like precursor analysis or evaluations of importance to safety. (authors)

  17. Accidental release of iodine 131 by the IRE of the Fleurus site: return on experience by the Belgian safety authority

    International Nuclear Information System (INIS)

    Vandecasteele, C.M.; Sonck, M.; Degueldre, D.

    2010-01-01

    After a presentation of the activities of the IRE, the Belgian National Institute of Radio-elements, i.e. the production of radionuclides used in nuclear medicine, this report describes the process and chemical reaction which caused an accidental release of iodine 131. It analyzes the causes of this incident, and how the incident has been managed by the Belgian safety authority. It discusses the first assessment of radiological consequences, describes how the incident has been managed at the federal level, and how population and media have been informed. It discusses the actual radiological consequences through measurements performed on grass and vegetables (graphs and maps indicate contamination levels and contaminated areas), and through the assessment of exposure of adults and children by different ways. Lessons learned are then discussed

  18. Urban environmental quality in two Belgian cities, evaluated on the basis of residential choices and GIS data

    OpenAIRE

    Isabelle Reginster; Florence Goffette-Nagot

    2005-01-01

    Our objective in this paper is to analyse empirically the effects of environmental quality on residential location choices in two Belgian cities, using a detailed description of the urban environment derived from remotely sensed data and using GIS tools. According to urban models which include amenities, environmental quality may influence land rents and location by income in the city. In order to test these relations, average land rents and mean income per district are regressed on distance ...

  19. Culture-Based Methods and Molecular Tools for Azole-Resistant Aspergillus fumigatus Detection in a Belgian University Hospital

    OpenAIRE

    Montesinos, I.; Argudín, M. A.; Hites, M.; Ahajjam, F.; Dodémont, M.; Dagyaran, C.; Bakkali, M.; Etienne, I.; Jacobs, F.; Knoop, C.; Patteet, S.; Lagrou, K.

    2017-01-01

    Azole-resistant Aspergillus fumigatus is an increasing worldwide problem with major clinical implications. Surveillance is warranted to guide clinicians to provide optimal treatment to patients. To investigate azole resistance in clinical Aspergillus isolates in our institution, a Belgian university hospital, we conducted a laboratory-based surveillance between June 2015 and October 2016. Two different approaches were used: a prospective culture-based surveillance using VIPcheck on unselected...

  20. The Exchange Programme of the Belgian American Educational Foundation: An Institutional Perspective on Scientific Persona Formation (1920-1940.

    Directory of Open Access Journals (Sweden)

    P. Huistra

    2016-12-01

    Full Text Available In this article we propose an institutional perspective on persona formation. Not unlike individual scientists, institutions such as funding bodies took an active interest in shaping the scientific persona. As a case in point, we discuss the Belgian American Educational Foundation (BAEF that sent hundreds of aspiring Belgian scientists to the United States during the Interwar period. The BAEF went to great lengths to optimise its selection procedure and formulated conditions pertaining to both the mental and physical fitness of its grantees. In this way, the BAEF cut off some repertoires of being a scientist and encouraged its fellows to demonstrate certain qualities when in front of the funding body. This, we argue, points to the performative and occasional character of scientific personae. Geschikt om te reizen. Het uitwisselingsprogramma van de Belgian American Education Foundation. Een institutioneel perspectief op de vorming van wetenschappelijke personae (1920-1940. In dit artikel benaderen wij de vorming van personae vanuit een institutioneel perspectief. Net als individuele wetenschappers zijn instituties zoals funding bodies actief betrokken bij het scheppen en in standhouden van wetenschappelijke personae. Als voorbeeld hiervan bespreken wij de Belgian American Educational Foundation (BAEF. In het Interbellum zond de BAEF honderden wetenschappers-in-wording naar de Verenigde Staten. Daarbij getroostte de organisatie zich veel moeite om de selectieprocedure te optimaliseren en stelde zij voorwaarden aan zowel de mentale als fysieke conditie van haar fellows. De BAEF maakte hiermee sommige repertoires van het wetenschapper-zijn onmogelijk, terwijl zij haar fellows aanmoedigde om bepaalde andere kwaliteiten voor het voetlicht te brengen voor de ogen van de funding body. Dit toont aan, zo betogen wij, dat de wetenschappelijke persona gesitueerd en performatief is.

  1. The Exchange Programme of the Belgian American Educational Foundation: An Institutional Perspective on Scientific Persona Formation (1920-1940

    Directory of Open Access Journals (Sweden)

    Pieter Huistra

    2016-12-01

    Full Text Available In this article we propose an institutional perspective on persona formation. Not unlike individual scientists, institutions such as funding bodies took an active interest in shaping the scientific persona. As a case in point, we discuss the Belgian American Educational Foundation (BAEF that sent hundreds of aspiring Belgian scientists to the United States during the Interwar period. The BAEF went to great lengths to optimise its selection procedure and formulated conditions pertaining to both the mental and physical fitness of its grantees. In this way, the BAEF cut off some repertoires of being a scientist and encouraged its fellows to demonstrate certain qualities when in front of the funding body. This, we argue, points to the performative and occasional character of scientific personae. Geschikt om te reizen. Het uitwisselingsprogramma van de Belgian American Education Foundation. Een institutioneel perspectief op de vorming van wetenschappelijke personae (1920-1940In dit artikel benaderen wij de vorming van personae vanuit een institutioneel perspectief. Net als individuele wetenschappers zijn instituties zoals funding bodies actief betrokken bij het scheppen en in standhouden van wetenschappelijke personae. Als voorbeeld hiervan bespreken wij de Belgian American Educational Foundation (BAEF. In het Interbellum zond de BAEF honderden wetenschappers-in-wording naar de Verenigde Staten. Daarbij getroostte de organisatie zich veel moeite om de selectieprocedure te optimaliseren en stelde zij voorwaarden aan zowel de mentale als fysieke conditie van haar fellows. De BAEF maakte hiermee sommige repertoires van het wetenschapper-zijn onmogelijk, terwijl zij haar fellows aanmoedigde om bepaalde andere kwaliteiten voor het voetlicht te brengen voor de ogen van de funding body. Dit toont aan, zo betogen wij, dat de wetenschappelijke persona gesitueerd en performatief is.

  2. Improved Emergency Preparedness For Management Of The Food chain Via Stakeholder Involvement: Belgian and European Experience

    International Nuclear Information System (INIS)

    Hardeman, Frank; Carle, Benny; Turcanu, Catrinel; Vandecasteele, Christian

    2006-01-01

    Initiatives involving stakeholder engagement have gained increasing importance in sustainable decision making for many risk-related issues. This paper describes a Belgian experience within a European context related to food management options in the event of a radioactive contamination of the food chain. Under the auspices of the European Commission's 5. Framework Programme, the F.A.R.M.I.N.G. (F.A.R.M.I.N.G. 2000) project (co-ordinated by H.P.A.) a stakeholder network was established in a number of European countries, following a successful approach originally adopted in the UK. In a comparable approach, national working groups were thus established in Belgium, Finland, France and Greece in order to organise stakeholder panels and to discuss the outcomes of scientific and technical research related to management options for the food chain. The results of these panels were exchanged between participating Member States and on a wider international basis at the W.I.S.D.O.M.2. workshop in 2003. The F.A.R.M.I.N.G. project had many achievements and there were also several important lessons learned for Belgium (Vandecasteele et al., 2005): Firstly, many stakeholders showed a real interest in tackling problems relating to food chain contamination; Secondly, the Belgian agricultural system is very intensive and technically and economically optimised, making many of the options envisaged difficult to implement; thirdly, the applicability of management options is also limited by political and legal issues (e.g. competencies, environmental legislation), operational constraints (e.g. waste treatment, supplies of materials), societal and ethical aspects (e.g. milk disposal to sea, animal welfare), and economics (e.g. who pays the intervention cost?); fourthly, there is a now a greater awareness of these problems in both the food production sector and among the experts involved in emergency management; Fifthly, increased attention is now given in Belgium to the medium and long

  3. Improved Emergency Preparedness For Management Of The Food chain Via Stakeholder Involvement: Belgian and European Experience

    Energy Technology Data Exchange (ETDEWEB)

    Hardeman, Frank; Carle, Benny [SCK.CEN, the Belgian Nuclear Research Centre, Boeretang 200, 2400 Mol (Belgium); Turcanu, Catrinel [Universite Libre de Bruxelles, Av. F. Roosevelt 50, 1050 Brussels (Belgium); Vandecasteele, Christian [FANC, Federal Agency for Nuclear Control, Ravensteinstraat 36, 1000 Brussels (Belgium)

    2006-07-01

    Initiatives involving stakeholder engagement have gained increasing importance in sustainable decision making for many risk-related issues. This paper describes a Belgian experience within a European context related to food management options in the event of a radioactive contamination of the food chain. Under the auspices of the European Commission's 5. Framework Programme, the F.A.R.M.I.N.G. (F.A.R.M.I.N.G. 2000) project (co-ordinated by H.P.A.) a stakeholder network was established in a number of European countries, following a successful approach originally adopted in the UK. In a comparable approach, national working groups were thus established in Belgium, Finland, France and Greece in order to organise stakeholder panels and to discuss the outcomes of scientific and technical research related to management options for the food chain. The results of these panels were exchanged between participating Member States and on a wider international basis at the W.I.S.D.O.M.2. workshop in 2003. The F.A.R.M.I.N.G. project had many achievements and there were also several important lessons learned for Belgium (Vandecasteele et al., 2005): Firstly, many stakeholders showed a real interest in tackling problems relating to food chain contamination; Secondly, the Belgian agricultural system is very intensive and technically and economically optimised, making many of the options envisaged difficult to implement; thirdly, the applicability of management options is also limited by political and legal issues (e.g. competencies, environmental legislation), operational constraints (e.g. waste treatment, supplies of materials), societal and ethical aspects (e.g. milk disposal to sea, animal welfare), and economics (e.g. who pays the intervention cost?); fourthly, there is a now a greater awareness of these problems in both the food production sector and among the experts involved in emergency management; Fifthly, increased attention is now given in Belgium to the medium and

  4. Postprandial glucose and not triglyceride concentrations are associated with carotid intima media thickness in women with normal glucose metabolism: the Hoorn prandial study.

    Science.gov (United States)

    Alssema, M; Schindhelm, R K; Dekker, J M; Diamant, M; Kostense, P J; Teerlink, T; Scheffer, P G; Nijpels, G; Heine, R J

    2008-02-01

    The present study aimed to compare the associations of postprandial glucose (ppGL) and postprandial triglycerides (ppTG) with carotid intima media thickness (cIMT) in women with normal glucose metabolism (NGM) and type 2 diabetes (DM2). Post-menopausal women (76 with NGM, 78 with DM2), received two consecutive fat-rich and two consecutive carbohydrate-rich meals on separate occasions. Blood samples were taken before and 1, 2, 4, 6 and 8h following breakfast; lunch was given at t=4. Ultrasound imaging of the carotid artery was performed to measure cIMT. In women with NGM, an increase of 1.0 mmol/l glucose following the fat-rich meals was associated with a 50 microm cIMT increase (p=0.04), and following the carbohydrate meals, an increase of 1.8 mmol/l glucose was associated with a 50 microm larger cIMT (p=0.08). These associations were not explained by classical cardiovascular risk factors. However, no association between ppGL and cIMT was found in women with DM2 and ppTG were not associated with cIMT. The association between ppGL and cIMT in normoglycaemic women suggests that ppGL in the normal range is a marker or a risk factor for atherosclerosis. Postprandial glucose levels might be a better indicator of risk than post-OGTT glucose levels or triglyceride levels.

  5. Prevalence and molecular typing of Coxiella burnetii in bulk tank milk in Belgian dairy goats, 2009-2013.

    Science.gov (United States)

    Boarbi, Samira; Mori, Marcella; Rousset, Elodie; Sidi-Boumedine, Karim; Van Esbroeck, Marjan; Fretin, David

    2014-05-14

    Q fever, a worldwide zoonosis, is an arousing public health concern in many countries since the recent Dutch outbreak. An emerging C. burnetii clone, genotype CbNL01, was identified as responsible for the Dutch human Q fever cluster cases. Since 2009, Q fever surveillance in the goat industry was implemented by the Belgian authorities. The herd prevalence (December 2009-March 2013) ranged between 6.3 and 12.1%. Genotypic analysis highlighted the molecular diversity of the Belgian strains from goats and identified an emerging CbNL01-like genotype. This follow-up allowed the description of shedding profiles in positive farms which was either continuous (type I) and associated to the CbNL01-like genotype; or intermittent (type II) and linked to other genotypes. Despite the circulation of a CbNL01-like strain, the number of notified Belgian human cases was very low. The mandatory vaccination (in June 2011) on positive dairy goat farms in Belgium, contributed to a decrease in shedding. Copyright © 2014 Elsevier B.V. All rights reserved.

  6. [Impact of an exercise program in adiposity and muscular condition of postmenopausal women].

    Science.gov (United States)

    Rocha, Josiane Santos Brant; Ogando, Betânia Maria Araujo; Reis, Vivianne Margareth Chaves Pereira; Matos e Avila, Waldney Roberto de; Carneiro, André Gomes; Gabriel, Ronaldo Eugénio Calcada Dias; Moreira, Maria Helena Rodrigues

    2012-09-01

    To evaluate the effect of an exercise program on fat mass (FM), visceral fat area (VFA), skeletal muscle mass (SMM) and skeletal muscle mass index (SMMI) of post-menopausal women. A sample of 169 women (56.8±6.4 years) was randomized into an exercise group (EG, n=91) and a control group (CG=78). The first performed 12 months of physical exercise, including step, weight training and flexibility, with three weekly sessions of 60 minutes each. The basal metabolic rate (BMR) and the corporal composition were evaluated by octopolar InBody 720 bioimpedance and the food record method was considered. The variables modification rates were determined and the comparison of the average values was realized by Student's t-test, with the level of significance of 5%. In absolute terms, the CG increased (p<0.01) the FM (1.8%) and VFA (3.9 cm²) and worsened muscle condition (-1.06%), with consequences for BMR (-27.9 kcal/day). Differences were found (p<0.05) between the EG and the CG for Δ% FM (-4.2%), ΔVFA (-4.00 cm²), ΔSM (3.09%), ΔSMI (0.03%) and ΔBMR (2.9%). The results suggest that exercise attenuated the increase in the levels of total and central adiposity and muscle loss associated with menopause and aging.

  7. Characterization of a dopamine transporter polymorphism and behavior in Belgian Malinois.

    Science.gov (United States)

    Lit, Lisa; Belanger, Janelle M; Boehm, Debby; Lybarger, Nathan; Haverbeke, Anouck; Diederich, Claire; Oberbauer, Anita M

    2013-05-30

    The Belgian Malinois dog breed (MAL) is frequently used in law enforcement and military environments. Owners have reported seizures and unpredictable behavioral changes including dogs' eyes "glazing over," dogs' lack of response to environmental stimuli, and loss of behavioral inhibition including owner-directed biting behavior. Dogs with severe behavioral changes may be euthanized as they can represent a danger to humans and other dogs. In the dog, the dopamine transporter gene (DAT) contains a 38-base pair variable number tandem repeat (DAT-VNTR); alleles have either one or two copies of the 38-base pair sequence. The objective of this study was to assess frequency of DAT-VNTR alleles, and characterize the association between DAT-VNTR alleles and behavior in MAL and other breeds. In an American sample of 280 dogs comprising 26 breeds, most breeds are predominantly homozygous for the DAT-VNTR two-tandem-repeat allele (2/2). The one-tandem-repeat allele is over-represented in American MAL (AM-MAL) (n = 144), both as heterozygotes (1/2) and homozygotes (1/1). All AM-MAL with reported seizures (n = 5) were 1/1 genotype. For AM-MAL with at least one "1" allele (1/1 or 1/2 genotype, n = 121), owners reported higher levels of attention, increased frequency of episodic aggression, and increased frequency of loss of responsiveness to environmental stimuli. In behavior observations, Belgian Military Working Dogs (MWD) with 1/1 or 1/2 genotypes displayed fewer distracted behaviors and more stress-related behaviors such as lower posture and increased yawning. Handlers' treatment of MWD varied with DAT-VNTR genotype as did dogs' responses to handlers' behavior. For 1/1 or 1/2 genotype MWD, 1) lower posture after the first aversive stimulus given by handlers was associated with poorer obedience performance; 2) increased aversive stimuli during protection exercises were associated with decreased performance; 3) more aversive stimuli during obedience were associated

  8. A survey on biosecurity and management practices in selected Belgian cattle farms.

    Science.gov (United States)

    Sarrazin, Steven; Cay, Ann Brigitte; Laureyns, Jozef; Dewulf, Jeroen

    2014-11-01

    The shift from cure towards prevention in veterinary medicine involves the implementation of biosecurity, which includes all measures preventing pathogens from entering a herd and reducing the spread of pathogens within a herd. In Belgium no studies have considered the implementation of biosecurity measures in the daily management of cattle farms. Therefore the aim of the study was to map the current application of biosecurity measures in Belgian cattle farms in the prevention of disease transmission within and between farms. Between March 2011 and April 2013 the data were collected as part of a larger cross-sectional study, conducted to identify risk factors for reinfection with BVDV in cattle herds assumed free from BVDV. Questionnaire data from 33 dairy farms, 16 beef farms and 25 mixed (dairy and beef cattle) farms were analyzed using a combination of a linear scoring system, a categorical principal component analysis and a two-step cluster analysis to differentiate these farms based on their biosecurity levels and visit frequencies. Further enhancement of preventive measures considering external and internal biosecurity was still possible for each farm, as none of the farms obtained an overall high biosecurity level. Three groups of cattle farms were differentiated with a biosecurity level varying from low to high-medium, of which the group with the lowest biosecurity level mainly consisted of mixed farms. Animal-to-animal contacts with cattle from other herds were frequently possible as only 12% of the farmers purchasing cattle quarantined purchased animals at least three weeks and contacts over fences on pasture were possible in 70% of the herds. Basic biosecurity measures such as farm-specific protective clothing and boots were present in the majority of the farms, but they were insufficiently or incorrectly used. Cattle farms were very often visited by professional visitors of which the herd veterinarian, the AI technician and the cattle salesman most

  9. Sustainable employability for older workers: an explorative survey of belgian companies.

    Science.gov (United States)

    Verbrugghe, Mathieu; Kuipers, Yoline; Vriesacker, Bart; Peeters, Ilse; Mortelmans, Katrien

    2016-01-01

    The European Agency for Safety and Health at Work (EU-OSHA) is developing an online e-guide, which will provide tips and practical information for each EU country (in their national language(s)) on ageing and occupational health and safety. The e-guide will be launched in 2016 as part of the EU-OSHA campaign on Healthy Workplaces for all ages. The e-guide will present evidence, tools and practical examples of how companies can take action and effectively promote sustainable employability. As part of the development of the e-guide, a cross-sectional study was conducted to survey Belgian employers in April 2015 to determine their specific needs concerning older workers' occupational health and safety issues. Researchers from Milieu Ltd. (Brussels, Belgium), the consultancy company coordinating the e-guide project, and Mensura Occupational Health Services (Brussels, Belgium) developed a 13-item questionnaire. The survey addressed the needs and importance given to sustainable employability of older workers in Belgian companies and evaluated corporate knowledge regarding relevant national policies. The questionnaire was distributed electronically to the management of 22,084 private-sector companies affiliated with Mensura. Ten percent (n = 2133) of recipients opened the e-mail, and 37 % (n = 790) of these completed the questionnaire. In 89 % of the responding companies, sustainable employability of workers aged ≥55 years plays an important role; 70 % have no active sustainable employability policy/initiative; 18 % experience difficulties promoting sustainable employability; and 86 % indicate no need for support to promote sustainable employability. Respondents noted the following health complaints among workers aged ≥55 years: work-related health problems (31 %), stress (26 %), work agreements/type of work (17 %), work/life balance (15 %), and career development and/or training (9 %). Topics concerning health and well-being of workers aged ≥55

  10. Breast cancer in Mexican women: an epidemiological study with cervical cancer control

    Directory of Open Access Journals (Sweden)

    Tovar-Guzmán Víctor

    2000-01-01

    Full Text Available INTRODUCTION: In Mexico, breast cancer (BC is one of the main causes of cancer deaths in women, with increasing incidence and mortality in recent years. Therefore, the aim of the study is identify possible risk factors related to BC. METHODS: An epidemiological study of hospital cases of BC and controls with cervical uterine cancer (CUCA was carried out at eight third level concentration hospitals in Mexico City. The total of 353 incident cases of BC and 630 controls with CUCA were identified among women younger than 75 years who had been residents of the metropolitan area of Mexico City for at least one year. Diagnosis was confirmed histologically in both groups. Variables were analyzed according to biological and statistical plausibility criteria. Univariate, bivariate and multivariate analyses were carried out. Cases and controls were stratified according to the menopausal hormonal status (pre and post menopause. RESULTS: The factors associated with BC were: higher socioeconomic level (OR= 2.77; 95%CI = 1.77 - 4.35; early menarche (OR= 1.32; 95%CI= 0.88 - 2.00; old age at first pregnancy (>31 years: OR= 5.49; 95%CI= 2.16 - 13.98 and a family hi