WorldWideScience

Sample records for behandling med azathioprin

  1. Epstein-Barr-virus-associeret lymfom hos en patient med colitis ulcerosa i behandling med azathioprin

    DEFF Research Database (Denmark)

    Kofoed, Kristian; Kiszka-Kanowitz, Marianne; Albrectsen, Jens Mørch; Andersen, Ove

    2008-01-01

    A 28 year-old man with ulcerative colitis treated for 10 years with azathioprine (AZA) returned from Central Asia with fever, swollen lymph glands, hepatosplenomegaly, and pancytopenia. He was tested positive for acute Epstein-Barr virus (EBV) infection. Before the final diagnosis of EBV-associat......A 28 year-old man with ulcerative colitis treated for 10 years with azathioprine (AZA) returned from Central Asia with fever, swollen lymph glands, hepatosplenomegaly, and pancytopenia. He was tested positive for acute Epstein-Barr virus (EBV) infection. Before the final diagnosis of EBV...

  2. Azathioprine

    Science.gov (United States)

    ... immediately if you notice any changes in your skin or any lumps or masses anywhere in your body.Some teenage and young adult males who took azathioprine alone or with another medication called a tumor necrosis factor (TNF) blocker to treat Crohn's disease (a ...

  3. Klasstödjare med EQ uppdrag : Ett verktyg mot kränkande behandling

    OpenAIRE

    Boman Linnman, Pernilla

    2008-01-01

    Syftet med mitt arbete har varit att undersöka hur en skola använder sig av klasstödjare och EQ i arbetet mot kränkande behandling.  Den frågeställning som jag har utgått från är: Hur ser värdegrundsarbetet ut på en skola, med avseende på likabehandlingsteam, klasstödjare och EQ uppdrag? I min undersökning har jag tagit del av hur en skola arbetar med ett likabehandlingsteam och klasstödjare. Likabehandlingsteamet består av två lärare som tillsammans med klasstödjare, bestående av elever arbe...

  4. Parent Management Training - en foreldreveiledningsmetodefor behandling av barn med atferdsproblemer. Teori, behandlingsprogram og implementering i Norge

    OpenAIRE

    Apelseth, Eva Fohlin; Amlie, Christine

    2001-01-01

    Antisosial atferd blant barn og ungdom er et stort og økende helsemessig og økonomisk problem. Parent Management Training – Oregon (PMT-O), et behandlings- og forebyggingsprogram for familier med barn som fremviser antisosial adferd, blir for tiden implementert i Norge som ledd i satsingen på psykisk helsevern. PMT-O er basert på ”social learning interaction theory”, utviklet av Patterson og medarbeidere ved Oregon Social Learning Center. PMT-O er et detaljert program for styrking av foreldre...

  5. Behandling mot alla odds : En kvalitativ studie om den offentliga sektorns förutsättningar för arbete med behandling av spelberoende

    OpenAIRE

    Ekeroth, Helena; Yngström, Henrik

    2015-01-01

    Denna studies syfte är att belysa hur professionella som i sitt yrke möter hjälpsökande spelberoende individer uppfattar och reflekterar kring möjligheten att arbeta med hjälp och behandling av spelberoende utifrån sin organisations förutsättningar och ansvar. Studien har genomförts genom djupintervjuer med professionella inom kommun, landsting, en privat ägd behandlingsorganisation och en nationell organisation inriktade mot spelberoende i syfte att erhålla en så bred bild av spektrumet som ...

  6. Hvilken evidens er der for behandling af depression hos børn og unge med kognitiv terapi?

    DEFF Research Database (Denmark)

    Sørensen, Merete Juul; Thomsen, Per Hove

    2007-01-01

    Depression hos børn og unge er relativt hyppigt forekommende og kan have svære konsekvenser. Den specifikke antidepressive behandling kan være psykoterapeutisk eller medikamentel. I artiklen gennemgås på baggrund af systematisk litteratursøgning den videnskabelige evidens for effekten af kognitiv...... adfærdsterapi hos børn og unge med depression....

  7. Tandlægers erfaringer med at foreslå og få gennemført behandling med kroner og broer i privat praksis

    DEFF Research Database (Denmark)

    Isidor, F.; Moore, R.

    2003-01-01

    insurance system to support patients in need for more expensive treatments. Dansk: Hvilke subjektive erfaringer har danske tandlæger i privat praksis med at foreslå og få gennemført behandling med kroner og broer? Et postomdelt spørgeskema blev udfyldt og returneret af 216 privatpraktiserende tandlæger i en......English:What subjective experiences have Danish dentists in private practice to propose and implement treatment with crowns and bridges? A mailed questionnaire were completed and returned by 216 private practice dentists for a random sample from Aarhus. Of these, 22% thought that it was...... gennemsnit kun 36% der faktisk får denne behandling. Tandlægerne mente at begrundelsen herfor var at patienterne havde manglende økonomisk mulighed eller en anden økonomisk prioritering. Tandlæger der syntes at det var ubehageligt at foreslå kroner og broer, angav mere end fem gange hyppigere manglende...

  8. Musikbiografi og musikreminiscens som led i musikterapeutisk behandling af personer med frontotemporal demens

    DEFF Research Database (Denmark)

    Ridder, Hanne Mette Ochsner

    2005-01-01

    At reflektere over sine følelser og sin egen situation, være kreativ og fantasifuld, og kunne planlægge og udføre målrettede handlinger hænger sammen med funktioner der involverer den forreste del af hjernen. Disse evner eller funktioner kan skades ved frontotemporale demensformer. Fra Rigshospit...

  9. Mentaliseringsbaseret behandling og musikterapi

    DEFF Research Database (Denmark)

    Hannibal, Niels

    2013-01-01

    Denne artikel behandler spørgsmålet, om mentaliseringsbaseret terapi er en metode der medfører et skift i terapeutisk forholdemåde for analytisk orienterede musikterapeuter i arbejde med patienter med personlighedsforstyrrelse. Artiklen skal ses om en del af den teoretiske integrationer af MBT i...

  10. Medikamentell behandling av gravide med bipolar lidelse : en vurdering av risiko for fødselsmalformasjoner

    OpenAIRE

    2010-01-01

    Background: A significant number of women of childbearing age have bipolar disorder. Several of the drugs used in the treatment of bipolar disorder have been associated with an increased risk of congenital malformation. Objective: The purpose of this review is to examine the risk of major congenital malformations related to medications used in the treatment of pregnant women with bipolar disorder. Methods: A literature research, using MEDLINE/PubMed, EMBASE and Cochrane databases...

  11. Regnskapsmessig behandling av mer- og mindreuttak i petroleumsbransjen : er praksis forenlig med IFRS og NGAAP?

    OpenAIRE

    Endresen, Helge; Kaarigstad, Ole Marius

    2015-01-01

    Denne oppgaven omhandler regnskapsmessige problemstillinger knyttet til mer- og mindreuttak av petroleum. Disse uttaksdifferansene oppstår både som følger av måten oppstrømsvirksomheten i mange tilfeller er organisert, og som følger av praktiske sider ved produksjonen av petroleum. Problemstillingene aktualiseres blant annet i og med publiseringen av ny inntektsstandard innenfor IFRS – IFRS 15. Dessuten er sitasjonen per i dag slik at den gjeldende inntektsstandarden, IAS 18, e...

  12. Svær interstitiel lungesygdom på grund af infliximab og azathioprin hos en patient med colitis ulcerosa

    DEFF Research Database (Denmark)

    Hansen, L. K.; Cecere, Stefano; Thøgersen, Thøger

    A 41-year-old man developed severe interstitial lung disease (ILD) after treatment with infliximab (IFX) and azathioprine (AZA). A relapse of ulcerative colitis was treated with corticosteroids (CS) and IFX as rescue therapy. Following remission AZA was given as prophylaxis. AZA was initiated the...

  13. Behandling med amiodaron

    DEFF Research Database (Denmark)

    Adelborg, Kasper; Ebbehøj, Eva; Nielsen, Jens Cosedis;

    2015-01-01

    Amiodarone is an effective antiarrhythmic drug for supra­ven­tri­cular and ventricular arrhythmias. A majority of patients treated with amiodarone suffer from mild adverse events, however, serious life-threatening adverse events caused by amiodarone are also seen. This review describes the...... pharmacology, interac­tions, side and adverse effects of amiodarone and highlights the importance of a systematic interdisciplinary follow-up protocol for outpatients treated with amiodarone....

  14. Behandling med implanterbar defibrillator

    DEFF Research Database (Denmark)

    Roseva-Nielsen, Natasha G; Svendsen, Jesper Hastrup

    2003-01-01

    About 20 years ago the first patient received an implantable cardioverter defibrillator (ICD), and since then the number of implants have increased dramatically. The ICD can terminate ventricular fibrillation and ventricular tachycardia. Studies of secondary prophylaxis show that ICD treatment can...

  15. Afasi og flerspråklighet : hvilke faktorer påvirker logopedisk behandling av personer med afasi og flerspråklig bakgrunn? : en spørreundersøkelse fra Tyskland

    OpenAIRE

    2004-01-01

    Sammendrag Tittel Oppgavens overordnede tittel er Afasi og flerspråklighet . Undertittelen beskriver problemstillingen Hvilke faktorer påvirker logopedisk behandling av personer med afasi og flerspråklig bakgrunn? En spørreundersøkelse fra Tyskland . Bakgrunn og formål Med tysk som morsmål og norsk som hverdagsspråk har jeg en personlig interesse for problemstillinger innen flerspråklighet. Å miste språkferdigheter som følge av en hjerneskade forandrer hverdagen til den ram...

  16. Fototerapi av nyfødte med hyperbilirubinemi: behov for bedre behandling og oppfølging, 93-98

    Directory of Open Access Journals (Sweden)

    Ellen B. Roll

    2009-10-01

    Full Text Available   Lysbehandling av nyfødte med gulsott har vært brukt i mer enn 30 år uten at metoden har blitt videreutvikleti noen særlig grad. Man regner med at mellom 5 og 10% av alle nyfødte blir lysbehandlet. Behandlingengjennomføres ved at barnet legges i synlig lys fra spesielle fototerapilamper i mange timer, opptilflere dager. Lysets bølgelengde og intensitet har stor betydning for effektiviteten av behandlingen, og enskal ikke se bort fra risikoen for bivirkninger. Resultater av behandlingen bør undersøkes grundigere, bådefor å vurdere hvor mye bilirubinmengden reduseres, og for å oppdage mulige bivirkninger. Med tanke påbivirkninger kan det ta mer enn 30 år før disse er manifestert. Oppfølgingsstudier som har blitt foretatt, kanha for små tidsrammer, og det kan være spørsmål om det er lyseffekter eller effekter av bilirubintoksisitetsom har blitt registrert. Målet med vårt kliniske og eksperimentelle arbeid på området er å foreta studiersom kan bidra til at behandlingen kan bli mer optimal, særlig med hensyn til lysets intensitet og bølgelengde.I vårt epidemiologiske arbeid ønsker vi å se på langtidseffekter av lysbehandling, spesielt kreftutvikling(lymfatisk leukemi og malignt melanom.Roll EB, Christensen T. Phototherapy of newborns with hyperbilirubinemia – need for better  . Nor J Epidemiol 1997; 7 (1: 93-98.  ENGLISH SUMMARYTreating jaundiced newborns with artificial light has been done for the last three decades without substantialimprovements of the method. It can be estimated that between 5 and 10% of all newborns receivephototherapy. The standard treatment is the use of artificial, visible light sources for many hours up toseveral days. The wavelength and intensity of the light are factors influencing the effect of the treatment,however, the risk for long-term side effects should be considered. The results of the treatment need morethorough investigation for two purposes; to evaluate the therapeutic

  17. Behandling af hydatidose med albendazol

    DEFF Research Database (Denmark)

    Magnussen, P; Gelletlie, R; Bygbjerg, Ib Christian

    1989-01-01

    the patients had varying degrees of liver involvement which were reversible. Neutropenia did not occur. Various parameters for assessing the therapeutic effect are mentioned. Albendazol appears to be effective in the treatment of non-operable hydatid disease and to prevent recurrence after surgery....

  18. Behandling af insulinom med alkoholsklerosering

    DEFF Research Database (Denmark)

    Schnack, Christina; Hansen, Carina Ørts; Beck-Nielsen, Henning;

    2012-01-01

    The efficacy and safety of endoscopic ultrasound (EUS)-guided alcohol ablation of an insulinoma in a patient not candidate for surgery is being evaluated. A 89 year-old male patient with insulinoma and serious cardiac disease was treated with EUS-guided alcohol ablation. The only complication was a...... slight degree of pancreatitis. Two months after the ablation values of plasma glucose and serum pro-insulin were normalized. EUS-guided alcohol ablation is a safe and efficient alternative to surgical resection of insulinomas in poor surgical candidates....

  19. Variationer av mindfulness i klinisk behandling

    OpenAIRE

    Wetterholm, Petra

    2008-01-01

    Mindfulness i klinisk behandling är ingen enhetlig företeelse. Ett flertal sätt att definiera, operationalisera och tillämpa mindfulness samexisterar i det kliniska rummet. Syftet med denna studie var att åskådliggöra terapeuters kvalitativt varierande sätt att beskriva, använda och uppleva mindfulness i klinisk behandling och att undersöka faktorer av betydelse för dessa variationer. Elva terapeuters arbete studerades genom semistrukturerade intervjuer varpå en teoristyrd tematisk analys av ...

  20. ”Mitt barns medicin” : En kvalitativ studie om föräldrars upplevelser av deras barns behandling med Modifierad Atkins Diet och ketogenkost.

    OpenAIRE

    Holmström, Annika; Mårtensson, Lotta

    2012-01-01

    BAKGRUND Modifierad Atkins Diet (MAD) och ketogenkost är kostbehandlingar som ordineras till barn med svårbehandlad epilepsi. Andra patientgrupper som behandlas med dessa dieter är patienter med glukostransportprotein typ 1-brist. Kostbehandlingarna är kolhydratfattiga och fettrika. I Sverige finns fyra sjukhus som arbetar med MAD och ketogenkost. I dagsläget saknas studier som beskriver hur behandlingarna upplevs av berörda familjer. SYFTE Syftet med studien var att utforska hur föräldrar ti...

  1. Forandring uden behandling

    DEFF Research Database (Denmark)

    Elmeland, Karen; Hecksher, Dorte

    Hvordan kan det være, at nogle mennesker kan komme ud af deres afhængighed uden at få behandling? Hvordan adskiller de sig fra dem, der søger behandling? Det er noget af det, der forskes i på Center for Rusmiddelforskning....

  2. Strategier for udredning og behandling af dyspepsi

    DEFF Research Database (Denmark)

    Jarbøl, Dorte Ejg; Kjeldsen, H.C.; Schaffalitzky de Muckadell, Ove B.

    2004-01-01

    almen praksis er empirisk behandling med antisekretorisk medicin, med efterfølgende endoskopi for nonrespondere. Noninvasiv test for Helico-bacter pylori (Hp) efterfulgt af eradikationskur til Hp-positive (Hp- test-and-treat ) er en strategi, der anbefales i flere guidelines til yngre patienter......Dyspepsi er et heterogent symptomkompleks, der dækker over smerte og ubehag i den øvre del af abdomen. Selv om området er genstand for stor opmærksomhed, er der ikke konsensus om den optimale udrednings- og behandlingsstrategi. Den mest anvendte strategi i behandlingen af ikkeundersøgt dyspepsi i...

  3. Modregning med uklare krav

    DEFF Research Database (Denmark)

    Madsen, Lars Henrik Gam

    Bogen redegør for risici forbundet med at gøre misligholdelse gældende, når den anden part modregner. I den forbindelse behandles den såkaldte standpunktsrisiko, dvs. risikoen ved at indtage et forkert standpunkt. Det belyses, hvordan de almindelige principper om modregning kan begrænse kreditors...

  4. Behandling af digital dermatitis på KFC

    DEFF Research Database (Denmark)

    Krogh, Kenneth; Thomsen, Peter

    2008-01-01

    På Kvægbrugets Forsøgscenter blev de rutinemæssige klovbade i maj 2007 erstattet med månedlige tjek af klove i beskærerboks og behandling af klovlidelser, herunder især Digital Dermatitis. Behandlingseffekten har været høj med 90 % helbredte efter en måned. Udgivelsesdato: april 2008......På Kvægbrugets Forsøgscenter blev de rutinemæssige klovbade i maj 2007 erstattet med månedlige tjek af klove i beskærerboks og behandling af klovlidelser, herunder især Digital Dermatitis. Behandlingseffekten har været høj med 90 % helbredte efter en måned. Udgivelsesdato: april 2008...

  5. Gruppebaseret behandling af BED - et faseopdelt behandlingstilbud

    DEFF Research Database (Denmark)

    Laust, Jakob; Lau, Marianne Engelbrecht; Waaddegaard, Mette

    2015-01-01

    konsekvenser. BED blev i 2013 optaget i DSM-5 (Diagnostic and Statistical Manual of Mental Disorders) som en selvstændig diagnose og BED forventes medtaget i den forestående revision af det internationale diagnose system, ICD-11. Sundhedsstyrelsen gav på denne baggrund satspuljemidler til erfaringsopsamling......Titel: Afrapportering vedr. SATS-puljemidler til behandling og erfaringsopsamling vedr. BED for perioden 1. marts 2013 – 1. maj 2015. Baggrund: Binge Eating Disorder (BED), på dansk tvangsoverspisning, er en udbredt, men overset spiseforstyrrelse med alvorlige psykiske, fysiske og sociale...

  6. Hvilken evidens er der for medikamentel behandling af depression hos børn og unge?

    DEFF Research Database (Denmark)

    Thomsen, Per Hove; Sørensen, Merete Juul

    2007-01-01

    Depression hos børn og unge er relativt hyppigt forekommende og kan have svære konsekvenser. Den specifikke antidepressive behandling kan være psykoterapeutisk eller medikamentel. I artiklen gennemgås på baggrund af systematisk litteratursøgning den videnskabelige evidens for medikamentel...... behandling af depression hos børn og unge med hovedvægten lagt på de mest veldokumenterede medikamenter: selektive serotoningenoptagelseshæmmere....

  7. Azathioprine induced cholestatic hepatitis

    OpenAIRE

    Viju Moses; Banumathi Ramakrishna; Kurien Thomas

    2011-01-01

    We report a case of cholestatic hepatitis developed one week after exposure to azathioprine. The subsequent prolonged cholestatic phase was followed by full clinical remission. Current knowledge on pathogenesis and epidemiology and the diagnostic challenges presented by this rare complication are discussed, followed by recommendations for monitoring and management.

  8. Azathioprine induced cholestatic hepatitis

    Directory of Open Access Journals (Sweden)

    Viju Moses

    2011-01-01

    Full Text Available We report a case of cholestatic hepatitis developed one week after exposure to azathioprine. The subsequent prolonged cholestatic phase was followed by full clinical remission. Current knowledge on pathogenesis and epidemiology and the diagnostic challenges presented by this rare complication are discussed, followed by recommendations for monitoring and management.

  9. Behandling af diabetes mellitus med biologiske laegemidler

    DEFF Research Database (Denmark)

    Larsen, Claus Morten; Mandrup-Poulsen, Thomas

    2008-01-01

    Biologic therapeutics are currently not approved for the treatment of patients with type 1 and type 2 diabetes. However, promising results from recent randomized controlled studies suggest that biologic therapeutics have therapeutic potential. This article summarizes the causal steps of the...... pathogenesis of type 1 and type 2 diabetes which are targeted by biologic therapeutics and reviews the treatment results. Udgivelsesdato: 2008-Jun-9...

  10. Nyrefunktionen under behandling med angiotensinkonverterende enzymhaemmere

    DEFF Research Database (Denmark)

    Rasmussen, K; Heitmann, M; Nielsen, J I;

    1995-01-01

    The use of ACE-inhibitors has increased greatly during the last years. They were first used in treating hypertension, but nowadays cardiac diseases, mainly cardiac failure, are common indications. This means that the drugs are used in the treatment of more elderly patients who often have generali......The use of ACE-inhibitors has increased greatly during the last years. They were first used in treating hypertension, but nowadays cardiac diseases, mainly cardiac failure, are common indications. This means that the drugs are used in the treatment of more elderly patients who often have...... generalised atherosclerosis. This means that the patients must be controlled more often after initiation of treatment, especially concerning kidney function, since treatment with ACE-inhibitors can cause pronounced changes in renal haemodynamics and kidney function. This review focuses on the effects of ACE-inhibitors...... on renal haemodynamics and kidney function, which may be positive, with preservation of kidney function in diabetic and other chronic nephropathy, or negative, for example in cases with atherosclerotic stenosis of large or small renal arteries. It is concluded, that in cases of diabetic nephropathy an ACE-inhibitor...

  11. Behandl dig selv med honning"

    DEFF Research Database (Denmark)

    Mejrup, Kristian; Bjerring-Nielsen, Mattias

    2015-01-01

    Abstract: This article has a twofold purpose: to investigate the symbolic richness and abundant sweetness of honey and to employ ‘honey treatment’ as a strategy for reading the honeycombapocalypse comprised in the Jewish legend of Joseph and Aseneth. This text tells of Aseneth’s encounter with a...... entirely perturbed and paralysed. In fact, her free speech and wits remain as if protected by a honeysweetened agency. The article emphasizes the necessity of a ‘conversion’ by the reader enabling him to grasp the sublime potential of the aesthetics of sweetness....

  12. Impotens forarsaget af behandling med methotrexat

    DEFF Research Database (Denmark)

    Penninga, Ida Elisabeth Irene; Larsen, H.K.; Andersen, S.E.

    2008-01-01

    Methotrexate (MTX) is used in the treatment of malignant and non-malignant diseases. This case report describes impotence as a seldom but possible overlooked adverse effect to MTX treatment. A 58 year-old man was treated for erythrodermia with a weekly dose of 7.5 mg MTX. He developed erective...

  13. Behandling med kosmetiske bløddelsfyldere

    DEFF Research Database (Denmark)

    Thyssen, Jacob Pontoppidan; Christensen, Lise H; Zachariae, Claus O C

    2007-01-01

    An increasing number of patients undergo soft-tissue augmentation. The quality depends on the applied filler substance, the compliance of the patient and the physician. Long-term adverse reactions are referred to as nodules or granulomas. Nodules following degradable gels and polyacrylamide...

  14. Behandling af ideopatisk hypereosinofilt syndrom med imatinib

    DEFF Research Database (Denmark)

    Sørensen, Anne Louise; Larsen, Herdis

    2008-01-01

    We here report a case of idiopathic hypereosinophilic syndrome with prompt response to treatment with imatinib. The patient presented with chest pain, myalgias, fatigue and weakness. Blood tests and bone marrow examination revealed striking eosinophilia. Clonal or reactive disorders were excluded...... by a wide range of diagnostic examinations. Treatment with high-dosis corticosteroids and hydroxyurea had little effect. Additional treatment with imatinib resulted in prompt symptomatic improvement and full haematological remission within five days of therapy. Udgivelsesdato: 2008-Jan-21...

  15. Alternativ behandling av pasienter med atopisk dermatitt

    OpenAIRE

    2007-01-01

    Abstract Atopic dermatitis is a persistent, chronic, relapsing inflammatory skin disease, presenting most often in early childhood. It is strongly linked to hay fever, asthma an bronkitis. The cause of atopic dermatitis is unknown, though a genetic pre-dispotition and a combination of allergic and non-allergic factors appear to be important in determining disease expression. Conventional treatment consists of emollients and corticosteroids, dietary manipulation and habit reversal. The in...

  16. Seksuelle bivirkninger ved behandling med psykofarmaka

    DEFF Research Database (Denmark)

    Kristensen, Ellids

    2002-01-01

    Hovedparten af psykofarmaka har seksuelle bivirkninger. De seksuelle bivirkninger kan medføre en reduceret livskvalitet og være årsag til nonkomplians. For eksempel angives for antidepressiva, at 30-60 % af de behandlede patienter udvikler seksuel dysfunktion. Efterhånden er der dog udviklet enke...... af seksuel dysfunktion, fx sildenafil. Overordnet må det imidlertid konstateres, at der foreligger relativt få data inden for dette område, og især savnes der kontrollerede undersøgelser. Udgivelsesdato: 2002-Oct-7...

  17. Behandling af Tourettes syndrom med aripiprazol

    DEFF Research Database (Denmark)

    Stenstrøm, Anne Dorte; Sindø, Ingrid

    2008-01-01

    Tourette's syndrome (TS) is a motoric disorder characterised by multiple motor and vocal tics. The treatment for patients with moderate to severe TS includes antipsychotic medication. A case report is described in which a 20 year-old male had taken antipsychotic medication since the age of five......, due to TS. The initial treatment consisted of pimozide and risperidone, both of which had an unsatisfactorily efficacy on tics and side effects in the form of weight gain and sedation. The patient is now treated with aripiprazole and there is a marked reduction of tics and no side effects...

  18. Bilateral akillesseneruptur efter behandling med ciprofloxacin

    DEFF Research Database (Denmark)

    Attarzadeh, Amir Pasha; Ryge, Camilla

    2013-01-01

    We report a case of spontaneous non-traumatic bilateral rupture of the Achilles tendons following ciprofloxacin treatment. A 54-year-old man presented with spontaneous Achilles tendon rupture on the left side, tendinitis and partial tear on the right side following few days of treatment with...... ciprofloxacin 500 mg twice daily and long-term treatment with prednisolon 10 mg once daily. This rare side effect caused by concurrent treatment with steroids and ciprofloxacin should be kept in mind. Any signs of tendinitis following this treatment should arouse the physicians' suspicion towards ciprofloxacin....

  19. Azathioprine treatment during lactation

    DEFF Research Database (Denmark)

    Christensen, L.A.; Dahlerup, J.F.; Nielsen, M.J.;

    2008-01-01

    BACKGROUND: Thiopurines are widely used to maintain remission in inflammatory bowel disease. Treatment during pregnancy is generally recommended to improve the chance of a normal birth outcome, but advice concerning breastfeeding is conflicting. Aim To estimate the exposure of breastfed infants to...... 6-mercaptopurine, as a metabolite of azathioprine, from maternal milk. METHODS: Eight lactating women with inflammatory bowel disease receiving maintenance therapy with azathioprine 75-200 mg daily were studied. Milk and plasma samples were obtained 30 and 60 min after drug administration and hourly...... maternal milk. After 6 h an average of 10% of the peak values were measured. CONCLUSIONS: The major part of 6-mercaptopurine in breast milk is excreted within the first 4 h after drug intake. On the basis of maximum concentration measured, the infant ingests mercaptopurine of <0.008 mg/kg bodyweight/24 h...

  20. Omkostningseffektivitet ved hypertensionsbehandling med Losartan i Danmark

    DEFF Research Database (Denmark)

    Keiding, Hans; Hildebrandt, Per; Burke, Thomas;

    2006-01-01

    Formålet med denne analyse var set såvel fra samfundets som fra det danske sundhedsvæsens perspektiv at evaluere omkostningseffektiviteten af losartan sammenlignet med atenolol ved behandling af hypertension, baseret på Losartan Intervention For Endpoint (LIFE)-undersøgelsens data Udgivelsesdato...

  1. Azathioprine for primary biliary cirrhosis

    DEFF Research Database (Denmark)

    Gong, Yanzhang; Christensen, E; Gluud, C

    Azathioprine is used for patients with primary biliary cirrhosis, but the therapeutic responses in randomised clinical trials have been conflicting.......Azathioprine is used for patients with primary biliary cirrhosis, but the therapeutic responses in randomised clinical trials have been conflicting....

  2. Mindfulness som smertehåndteringsredskab for kvinder med endometriose

    DEFF Research Database (Denmark)

    Jensen, Mette Kold; Vedsted-Hansen, Hanne; Hansen, Tia G. B.

    2011-01-01

    Endometriose er en kronisk underlivssygdom med smerter og en række afledte problemer, som ikke nødvendigvis kan behandles med lægelige tiltag. Artiklen argumenterer for, at en mindfulness-baseret tilgang med fokus på smertehåndtering kan anvendes til denne klientgruppe. I vestlig terapeutisk samm...

  3. Evidens for akupunktur til patienter med kvalme og opkastning i forbindelse med kemoterapi? Et litteraturstudie

    DEFF Research Database (Denmark)

    Pedersen, Birgith; Bundgaard Sørensen, Lene; Stricker, Lisbeth;

    2008-01-01

    Patienter, der får kemoterapi med højemetogene stoffer lider stadig af kvalme og opkastning trods understøttende behandling med moderne antieemtika som 5HT3-antagonister eksempelvis ondansetron. Akupunkturstimulation anvendes for flere lidelser i sundhedsvæsenet og det undersøges om der er evidens...

  4. Akupunktur til patienten med kvalme og opkastning i forbindelse med kemoterapi - er der evidens for dette?

    DEFF Research Database (Denmark)

    Pedersen, Birgith; Sørensen, Lene Bundgaard; Stricker, Lisbeth;

    2008-01-01

      Patienter, der får kemoterapi med højemetogene stoffer lider stadig af kvalme og opkastning trods understøttende behandling med moderne antieemtika som 5HT3-antagonister eksempelvis ondansetron. Akupunkturstimulation anvendes for flere lidelser i sundhedsvæsenet og det undersøges om der er...

  5. Hypersensitivity and jaundice due to azathioprine.

    OpenAIRE

    Davis, M.; Eddleston, A L; Williams, R.

    1980-01-01

    A patient is described who suffered hypersenitivity reactions (anorexia, nausea and vomiting) as well as cholestatic jaundice from therapy with azathioprine. Evidence is given that the 2 reactions were mediated by different portions of the azathioprine molecule.

  6. Compound list: azathioprine [Open TG-GATEs

    Lifescience Database Archive (English)

    Full Text Available azathioprine AZP 00046 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human.../in_vitro/azathioprine.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/i...n_vitro/azathioprine.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vi...vo/Liver/Single/azathioprine.Rat.in_vivo.Liver.Single.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates

  7. Chronic idiopathic polyneuropathy treated with azathioprine.

    OpenAIRE

    Pentland, B; Adams, G G; Mawdsley, C

    1982-01-01

    The results of azathioprine therapy in five patients with chronic progressive or relapsing idiopathic inflammatory polyneuropathy are described. In four patients a sustained improvement followed treatment and in the other patient azathioprine successfully replaced corticosteroid therapy. The improvement was often delayed for up to three months. The literature on the use of azathioprine in chronic polyneuropathy is reviewed. We suggest that there is a place for azathioprine treatment in patien...

  8. Alternativ behandling og kræft

    DEFF Research Database (Denmark)

    Lunde, Anita; Johannessen, Helle

    2010-01-01

    Baggrund: Interessen for komplementær og alternativ behandling (KAB) er stadig stigende, og der kan dokumenteres et større forbrug af KAB blandt kræftpatienter. Patienter anvender primært KAB som supplement til deres konventionelle behandling, og mange så gerne KAB som en integreret praksis. Fler...

  9. Forskning i ergoterapeutisk behandling indenfor neurorehabilitering - en stor udfordring og nødvendighed!

    DEFF Research Database (Denmark)

    Schow, Trine

    2011-01-01

    Der sker i disse år meget indenfor både forskning og behandling i neurorehabilitering. Både grundforskning og kliniske studier bidrager til viden om neuroplasticitet og til udvikling og dokumentation af forskellige behandlingsformer og det er vigtigt at det ergoterapeutiske felt følger med. Denne...

  10. Utvärdering av prehospital vård och behandling av hjärtinfarktpatienter med tromboshämmande läkemedel : En fall/kontroll studie efter införandet av ny behandlingsrutin

    OpenAIRE

    Wasniowski, Benjamin; Melin, Carina

    2008-01-01

    Introduktion: Akut hjärtinfarkt är en vanlig dödsorsak. Viktigaste behandlingsinsatsen vid hjärtinfarkt är att snabbt öppna det ockluderade kranskärlet genom primär Perkutan Coronar Intervention (PCI). Viktigt är även att behandlingen förhindrar att kärlet åter ockluderar. Detta görs genom att behandla med det blodproppshämmande och kärlpåverkande läkemedlet Clopidogrel. Enligt en ny behandlingsrutin ges Clopidogrel redan i ambulansen vid konstaterande av hjärtinfarkt för att uppnå effekt så ...

  11. Livscyklusvurdering af behandling af deponeret shredderaffald

    DEFF Research Database (Denmark)

    Møller, Jacob; Damgaard, Anders; Brogaard, Line Kai-Sørensen;

    Denne rapport indeholder en livscyklusbaseret miljøvurdering (LCA) af behandling af deponeret shredderaffald. Livscyklusvurderingen blev udført for Miljøstyrelsen af DTU Miljø i perioden 2013-2014 som en del af en ydelsesaftale mellem Miljøstyrelsen og DTU om forskningsbaseret myndighedsbetjening...... in-den for affaldsområdet. Rapporten indgår i en større undersøgelse vedrørende bedre ressourceud-nyttelse af affald, hvori såvel den miljømæssige som den samfundsøkonomiske konsekvens for forskellige scenarier vedr. affaldshåndtering af shredderaffald, imprægneret træ, træ til genanven-delse samt...... fjernvarmerør undersøges. Livscyklusvurderingen blev udført vha. LCA-modellen EA-SETECH, som er udviklet af DTU Miljø til miljøvurdering af affaldssystemer. Livscyklusvurderingen blev udført i overensstemmelse med principperne for LCA, som beskrevet i DS/EN ISO-standard 14044. Afrapporteringen følger ISO...

  12. Multiple cutaneous neutropenic ulcers associated with azathioprine

    OpenAIRE

    Baisakhi Laha; Rajib Guha; Avijit Hazra

    2012-01-01

    We report a case of neutropenic ulceration in a 42-year-old woman receiving azathioprine for pemphigus vulgaris. She developed multiple indolent ulcers involving the nose, neck, and back, after about 6–8 weeks following commencement of azathioprine 50 mg daily. The ulcers were large, disfiguring, dry, and with basal necrotic slough. They were painless and did not discharge pus. The absolute neutrophil count was severely depressed initially, but normalized following azathioprine withdrawal. Sw...

  13. Pancytopenia related to azathioprine in rheumatoid arthritis.

    OpenAIRE

    Jeurissen, M E; Boerbooms, A M; van de Putte, L B

    1988-01-01

    Two patients with rheumatoid arthritis developed pancytopenia during treatment with azathioprine 100 mg daily. In one patient this side effect occurred after three weeks, in the other after eight weeks of treatment. Rapid fall of platelets in one patient necessitated platelet transfusion. In the other patient additional treatment with allopurinol was probably responsible for the toxic effect. Haematological side effects of azathioprine are discussed.

  14. Azathioprine favourably influences the course of malaria

    OpenAIRE

    Huber Stephan M; Föller Michael; Geiger Corinna; Koka Saisudha; Bobbala Diwakar; Lang Florian

    2009-01-01

    Abstract Background Azathioprine triggers suicidal erythrocyte death or eryptosis, characterized by cell shrinkage and exposure of phosphatidylserine at the erythrocyte surface. Eryptosis may accelerate the clearance of Plasmodium-infected erythrocytes. The present study thus explored whether azathioprine influences eryptosis of Plasmodium-infected erythrocytes, development of parasitaemia and thus the course of malaria. Methods Human erythrocytes were infected in vitro with Plasmodium falcip...

  15. Folkeretlige problemstillinger i forbindelse med konflikten mellem Ukraine og Rusland

    DEFF Research Database (Denmark)

    Buhl, Kenneth Øhlenschlæger

    Konflikten mellem Ukraine og Rusland udgør en trussel mod den internationale retsorden og dermed også hele den europæiske orden. Med henblik på at give et grundlag for at forstå omfanget af dette aspekt af konflikten behandles her lovligheden af nogle af de handlinger, som har været konfliktens...

  16. Forebyggelse og behandling af osteoporose i forbindelse med behandling af ikke-metastaserende prostatacancer

    DEFF Research Database (Denmark)

    Eiken, Pia Agnete; Langdahl, Bente Lomholt; Eiken, Frederik L;

    2011-01-01

    The prevention of cancer treatment-induced bone loss in patients with prostatae cancer due to gonadotropin-releasing hormone (GnRH)-agonist, GnRH-antagonist and orchidectomi therapy has a high priority. We present an algorithm for the prevention and treatment of osteoporosis during treatment of non......-metastatic prostate cancer....

  17. Hon må väl få behålla sin anorexi då : Behandlares upplevelser av utmaningar och svårigheter i behandling av anorexia nervosa

    OpenAIRE

    Nilsson, Tina; Sandström, Johanna

    2011-01-01

    Anorexia nervosa är en svårbehandlad sjukdom med hög dödlighet (Fichter, Quadflieg & Hedlund,2006). Studiens syfte var att undersöka behandlares upplevelser av utmaningar och svårigheter i behandling av patienter med anorexia nervosa som vid behandlingsavslut har kvarvarande symtom, samt sätta upplevelserna i relation till ett patientperspektiv. Semistrukturerade intervjuer genomfördes med sju behandlare. Intervjumaterialet analyserades med Interpretative Phenomenological Analysis (IPA) o...

  18. Severe megaloblastic anaemia associated with abnormal azathioprine metabolism.

    OpenAIRE

    Lennard, L; Murphy, M F; Maddocks, J L

    1984-01-01

    Severe anaemia is a rare, unexplained, side effect of azathioprine therapy. We report here such a case associated with a previously unreported abnormality in azathioprine metabolism. A 57 year old man on azathioprine therapy, for a presumed collagen vascular disease, developed severe megaloblastic anaemia. This resolved on cessation of azathioprine treatment. A very high concentration of an azathioprine metabolite, 6-thioguanine nucleotide, was found in the patient's red blood cells and this ...

  19. Leucocytoclastic vasculitis in a patient with azathioprine hypersensitivity.

    OpenAIRE

    Beckett, C. G.; Hill, P.; Hine, K R

    1996-01-01

    We report the case of a 77-year-old man admitted nine days after being commenced on azathioprine with symptoms initially thought to be secondary to sepsis but in fact due to azathioprine hypersensitivity. He developed histologically proven cutaneous leucocytoclastic vasculitis following the re-introduction of azathioprine. We review the literature concerning adverse reactions to azathioprine and the problems of making the diagnosis as well as highlighting azathioprine as a novel cause of leuc...

  20. Karakteristik, diagnostik og behandling af patienter med autoimmun hepatitis

    DEFF Research Database (Denmark)

    Ytting, Henriette; Larsen, Fin Stolze

    2012-01-01

    Autoimmune hepatitis is a relatively rare disease that may lead to rapidly progressing liver cirrhosis and even fulminant liver failure, if diagnosis and treatment is delayed or ineffective. Diagnosing the disease can be challenging, and one in five patients respond insufficiently to standard...

  1. Behandling af patienter med Guillan Barré syndrom

    DEFF Research Database (Denmark)

    Oliel, Vibeke S.

    2011-01-01

    Resumè Guillain Barrés syndrom er en autoimmum sygdom karakteriseret ved motorisk, sensorisk og autonom dysfunktion. I Danmark rammes omkring 80 personer i alle aldre årligt af sygdommen. Akut inflammatorisk polyradikoloneuropati rammer de perifere nervers nerveskeder og medfører progredierende...

  2. Palliativ behandling af patienter med terminal kronisk obstruktiv lungesygdom

    DEFF Research Database (Denmark)

    von Plessen, Christian; Nielsen, Thyge L; Steffensen, Ida E; Larsen, Shuruk Al-Halwai; Taudorf, Ebbe

    2011-01-01

    Terminal chronic obstructive pulmonary disease (COPD) and advanced cancer have similar prognosis and symptom burden. However, palliative care of patients with terminal COPD has been neglected in Denmark. We describe the symptoms of terminal COPD and suggest criteria for defining the palliative ph...... phase of the disease. Furthermore we discuss the prognostic and ethical challenges for patients, their families and their caregivers. Finally, we summarize the current evidence for palliative treatment of dyspnoea and ways to evaluate response to treatment....

  3. Graviditet i livmoderhalsen kan behandles konservativt med methotrexat

    DEFF Research Database (Denmark)

    Sørensen, Marie; Clausen, Helle Vibeke

    2011-01-01

    systemic methotrexate. The patient with the living cervical ectopic pregnancy had stable vital signs during the period of treatment. The patient with the fetal pole was admitted with heavy vaginal bleeding and anaemia and was stabilised before treatment was initiated. She was stable throughout the...

  4. Palliativ behandling af patienter med terminal kronisk obstruktiv lungesygdom

    DEFF Research Database (Denmark)

    von Plessen, Christian; Nielsen, Thyge L; Steffensen, Ida E;

    2011-01-01

    Terminal chronic obstructive pulmonary disease (COPD) and advanced cancer have similar prognosis and symptom burden. However, palliative care of patients with terminal COPD has been neglected in Denmark. We describe the symptoms of terminal COPD and suggest criteria for defining the palliative...

  5. Autisme : En litteraturstudie med hovedvekt på behandling

    OpenAIRE

    2006-01-01

    ABSTRACT: Our understanding and treatment of children with autism have changed dramatically since Leo Kinner first formally documented this disorder in 1943. This paper looks at the treatment of autism in children. The main focus of the paper is Pharmacological treatment with anti-depressives (SSRI and TCA), anti-psycotics and the hormone secretin and dietary intervention with Gluten and/or Casein free diets. The conclusion of the paper is that we still need a lot more research in ord...

  6. Behandling af gastrointestinal blodning fra angiodysplasier med somatostatinanalogen octreotid

    DEFF Research Database (Denmark)

    Boesby, L.; Kristensen, L.O.; Christensen, Niels Juel

    2008-01-01

    Angiodysplasias account for 2-8% of GI-bleeding episodes. We describe a 75-year-old patient with a history of anaemia for 1 year before being diagnosed with multiple angiodysplasias in the GI-tract. The patient needed weekly blood transfusions until he started treatment with octreotide. After 4...... months of treatment the need for transfusions had decreased dramatically and faeces was negative for blood. Treatment was switched to long-acting octreotide (Sandostatin Lar). The case illustrates the usefulness of somatostatin analogues in the treatment of bleeding GI-angiodysplasias Udgivelsesdato...

  7. Den haemostatiske balance under behandling med nyere p-pillepraeparater

    DEFF Research Database (Denmark)

    Petersen, K R; Skouby, S O; Sidelmann, Johannes Jakobsen;

    1994-01-01

    concentration of tissue plasminogen activator inhibitor. The ratio between thrombin-antithrombin-III-complexes and fibrin degradation products were unchanged signifying no effect of hormonal intake on the balance between thrombin formation and fibrin resolution. In conclusion, the dynamic balance between...... generation and resolution of fibrin was undisturbed during treatment with both hormonal compounds and our findings do not provide evidence for increased risk of thrombosis in normal women....

  8. Behandling af pilonidalcyster med neodynium-yttriumaluminiumgranat-laser

    DEFF Research Database (Denmark)

    Lindholt, Christine S; Lindholt, Jes Sanddal; Lindholt, Jan

    2008-01-01

    A 23 year-old woman with a nonsupporative pilonidal cyst was successfully treated causally with Nd-YAG laser, and without any recidivate after 9 months follow-up. The mechanism is presumed to be that YAG-laser has a wave-length of 1064 nm. Consequently, the wave penetration through the skin is de...... deeper than most other lasers before the energy is absorbed in melanin and oxyhaemoglobin, so the contents of the cyst can be reached and destroyed. The treatment could be a very attractive alternative to open surgery....

  9. Behandling af pilonidalcyster med neodynium-yttriumaluminiumgranat-laser

    DEFF Research Database (Denmark)

    Lindholt, Christine S; Lindholt, Jes S; Lindholt, Jan

    2008-01-01

    A 23 year-old woman with a nonsupporative pilonidal cyst was successfully treated causally with Nd-YAG laser, and without any recidivate after 9 months follow-up. The mechanism is presumed to be that YAG-laser has a wave-length of 1064 nm. Consequently, the wave penetration through the skin is de...... deeper than most other lasers before the energy is absorbed in melanin and oxyhaemoglobin, so the contents of the cyst can be reached and destroyed. The treatment could be a very attractive alternative to open surgery. Udgivelsesdato: 2008-Jun-23...

  10. Omkostningseffektivitet ved behandling af type 1-diabetes med insulinpumpe

    DEFF Research Database (Denmark)

    Nørgaard, Kirsten; Sohlberg, Anna; Goodall, Gordan

    2010-01-01

    This study's aim was to project the long-term clinical and economic outcomes of continuous subcutaneous insulin infusion (CSII) treatment compared to multiple daily injections (MDI) in type 1 diabetes patients in Denmark....

  11. Behandling af metforminassocieret laktatacidose med hæmodialyse

    DEFF Research Database (Denmark)

    Schousboe, K.; Rasmussen, K.; El Fassi, D.;

    2012-01-01

    Metformin-associated lactate acidosis is rare but serious and characterized by metabolic acidosis and elevated lactate. We describe a single-institution experience of four cases in one year. Despite pH levels of 6.85 to 7.12 and lactate levels of 11-28 mmol/l three of the patients survived. Two o...... the patients had normal kidney function previous to hospitalization. Treatment includes fluid replacement, IV sodium bicarbonate and haemodialysis....

  12. Muskuloskeletal behandling af 11-årig med artrogrypose

    DEFF Research Database (Denmark)

    Thomsen, Maria Morandi; Thomsen, Stig Aaberg; Due, Pernille

    2010-01-01

    A two-year-old patient was diagnosed with arthrogryposis because of inflected knees (15-20 degrees) and stiff hamstrings. All joints and reflexes were normal. Activities were described as age-appropriate, but the patient walked with inflected knees and increased lumbal lordosis. Physiotherapy and...

  13. Behandling af invert papillom med endonasal endoskopisk sinuskirurgi

    DEFF Research Database (Denmark)

    Andersen, Pia Juul; Kjeldsen, Anette Drøhse; Pedersen, Arne Toft

    2002-01-01

    INTRODUCTION: Inverted papilloma is a benign sinonasal tumour and has a marked tendency to recur after surgical excision. The tumour may be associated with malignancy and during growth it may destroy surrounding tissue. The treatment is either lateral rhinotomy or endoscopic sinus surgery. The aim...... of the study was to describe the course of all patients treated with endoscopic sinus surgery at the ENT Department at Vejle County Hospital during the period 1 January to 31 December 1999. MATERIAL AND METHODS: Twenty-eight journals of patients diagnosed with inverted nasal papillomas were reviewed...... with carcinoma. We did not see any serious side effects to the treatment. DISCUSSION: Endoscopic sinus surgery in combination with Caldwell-Luc can be recommended as an alternative treatment to lateral rhinotomy in patients with inverted papillomas. Preoperative staging with CT or MR...

  14. Legionella pneumoni hos patienter, der er i behandling med infliximab

    DEFF Research Database (Denmark)

    Vinter, Hanne; Nielsen, Henrik Ib

    2009-01-01

    Therapy with tumour necrosis factor-alfa inhibitors is widely used in various inflammatory disorders, but adverse events from severe infections with intracellular pathogens may occur. We describe two cases of severe pulmonary legionellosis in patients treated with infliximab for Crohn's disease a...... psoriasis, respectively. We conclude that legionella infections are probably more frequent in patients receiving immunosuppressive therapy with tumour necrosis factor-alfa inhibitors than in the background population. Udgivelsesdato: 2009-Jan-19...

  15. Bedre prognose af cystinose ved behandling med cysteamin og nyretransplantation

    DEFF Research Database (Denmark)

    Oczachowska-Kulik, Anne; Lund, A M; Skovby, F;

    2011-01-01

    Cystinosis is a rare, autosomal recessive disease with cystine deposits in different tissues. First signs come from kidneys and eyes, but during progression of the disease other organs can also be affected. Previously, patients with cystinosis had a very poor prognosis, but it is now considerably...... improved due to new methods of treatment. The purpose of this paper is to give a brief review of the disease and discuss the significant improvement of the prognosis, which has been achieved by specific medical treatment with cystine-depleting agents, and, if needed, by kidney transplantation....

  16. Safety of azathioprine use during pregnancy

    OpenAIRE

    Natekar, Aniket; Pupco, Anna; Bozzo, Pina; Koren, Gideon

    2011-01-01

    Question Quite a few of my female patients with rheumatic diseases and inflammatory bowel disease are using azathioprine. They are afraid to take a “cancer drug” during pregnancy. What is known about the risks?

  17. Azathioprine in chronic relapsing idiopathic polyneuropathy.

    OpenAIRE

    Pentland, B

    1980-01-01

    A 33-year-old housewife with a 14-year history of relapsing polyneuropathy of unknown cause who has apparently responded to azathioprine therapy is described. The place of this form of treatment in idiopathic polyneuropathy is discussed.

  18. Hypersensitivity to azathioprine in myasthenia gravis.

    OpenAIRE

    Watts, G. F.; Corston, R.

    1984-01-01

    A patient with myasthenia gravis is described who exhibited hypersensitivity including an apparent acute exacerbation of the underlying disorder when treated with azathioprine. 6-mercaptoprine (6-MP) also produced hypersensitivity which, in contrast, did not manifest as a myasthenic exacerbation.

  19. Azathioprine-induced fever in autoimmune hepatitis

    OpenAIRE

    Tawfik Khoury; Ollech, Jacob E; Shmuel Chen; Meir Mizrahi; Meir Shalit

    2013-01-01

    Underdiagnosis of drug-induced fever leads to extensive investigation and prolongation of hospitalization, and may lead to multiple unnecessary invasive procedures and a wrong diagnosis. Azathioprine is a widely used immunosuppressive drug. We report a case of a 53-year-old female patient diagnosed with autoimmune hepatitis treated with azathioprine, who presented to the emergency room with a 6-wk history of fever and chills without other associated symptoms. Since the patient’s fever ...

  20. Azathioprine associated acute respiratory distress syndrome: case report and literature review

    OpenAIRE

    Scherbak D; Wyckoff R; Singarajah C

    2014-01-01

    A 58-year-old Caucasian man treated with azathioprine to prevent rejection of an orthotopic liver transplant, presented to the Carl Hayden VA Medical Center with rapid respiratory decline and appeared septic. He required urgent intubation, mechanical ventilator support and empiric antibiotics. His clinical picture and imaging studies were consistent with acute respiratory distress syndrome; however, extensive infectious work up failed to reveal an offending organism. Review of his current med...

  1. "Hvis noen forteller om mobbing..." Utdypende undersøkelse av funn i Elevundersøkelsen om mobbing, urettferdig behandling og diskriminering

    OpenAIRE

    Lødding, Berit; Vibe, Nils

    2010-01-01

    Denne rapporten skal bidra til å forklare forskjeller mellom skoler når det gjelder andeler av elevene som over tid har rapportert om mobbing, urettferdig behandling eller diskriminering i Elevundersøkelsen. I hvilken grad programmer for å forebygge mobbing og bedre læringsmiljøet har effekt, er også en del av oppdraget fra Utdanningsdirektoratet. Hva elevene forstår med begrepene mobbing, urettferdig behandling og diskriminering og i hvilken grad de klarer å reflektere rundt begrepene, er og...

  2. Association between azathioprine therapy and lymphoma in rheumatoid disease.

    OpenAIRE

    Pitt, P I; Sultan, A H; Malone, M; Andrews, V.; Hamilton, E. B.

    1987-01-01

    Three out of 41 patients treated with azathioprine and low-dose corticosteroids from 1976 to 1983 developed non-Hodgkin's lymphoma. This strikingly high incidence of lymphoma may be a reflection of long-term use of azathioprine.

  3. Infliximab, azathioprine, or combination therapy for Crohn's disease

    DEFF Research Database (Denmark)

    Colombel, Jean Frédéric; Sandborn, William J; Reinisch, Walter;

    2010-01-01

    The comparative efficacy and safety of infliximab and azathioprine therapy alone or in combination for Crohn's disease are unknown.......The comparative efficacy and safety of infliximab and azathioprine therapy alone or in combination for Crohn's disease are unknown....

  4. Klinisk retningslinje for udredning og klassificering af personer med nakkebesvær

    DEFF Research Database (Denmark)

    Kjær, Per; Eirikstoft, Heidi; Ris Hansen, Inge

    2010-01-01

    anbefalinger til: • overordnet klassifikation af nakkebesvær • identificering af tegn på alvorlig patologi (røde flag) • identificering af personer med risiko for at udvikle uhensigtsmæssige copingstrategier i forbindelse med nakkebesvær • identificering af personer med risiko for at miste tilknytning til...... arbejdsmarked (gule flag) • identificering af mulige differentialdiagnoser • klassificering af almindelige lidelser i nakken med henblik på specifik behandling Patienter Retningslinjen giver anbefalinger om fysioterapeutisk undersøgelse og diagnostik af personer med uspecifikke nakkesmerter med eller uden...

  5. Portal hypertension secondary to azathioprine in myasthenia gravis.

    OpenAIRE

    Fonseca, V.; Havard, C W

    1988-01-01

    A 52 year old man with myasthenia gravis and normal liver function was treated with neostigmine, prednisolone and azathioprine. Three years after starting azathioprine he developed clinical evidence of portal hypertension. A liver biopsy showed nodular regenerative hyperplasia (NRH). The development of NRH following azathioprine treatment in a patient with myasthenia gravis strengthens the case for a causal role of azathioprine in producing NRH and portal hypertension.

  6. EMDR-behandling  : Barns och ungdomars upplevelser en kvalitetssäkringsstudie 

    OpenAIRE

    Fredin, Ingela

    2005-01-01

    Föreliggande studie är dels ett led i att kvalitetssäkra EMDR (Eye Movement Desensitization and Reprocessing) som behandlingsmetod för barn och ungdomar och dels att utröna om behandlingen bidragit till ett förbättrat mående. EMDR som behandlingsmetod för barn och ungdomar har stöd i kontrollerade studier, men ytterligare forskning behövs. I den här studien deltog åtta barn och ungdomar med varierande diagnoser, vilka fått EMDR-behandling i barn- och ungdomspsykiatrisk öppenvård. Behandlingen...

  7. Weekly azathioprine pulse versus daily azathioprine in the treatment of Parthenium dermatitis: A non-inferiority randomized controlled study

    OpenAIRE

    Kaushal K Verma; G Sethuraman; M Kalavani

    2015-01-01

    Background: Azathioprine in daily doses has been shown to be effective and safe in the treatment of Parthenium dermatitis. Weekly pulses of azathioprine (WAP) are also effective, but there are no reports comparing the effectiveness and safety of these two regimens in this condition. Aims: To study the efficacy and safety of WAP and daily azathioprine in Parthenium dermatitis. Methods: Sixty patients with Parthenium dermatitis were randomly assigned to treatment with azathioprine 300 mg weekly...

  8. Are we giving azathioprine too much time?

    Institute of Scientific and Technical Information of China (English)

    Fernando Gomollón; Santiago García López

    2008-01-01

    Azathioprine is Currently the key drug in the maintenance treatment of inflammatory bowel diseases. However, there are still some practical issues to be resolved: one is how long we must maintain the drug. Given that inflammatory bowel diseases are to date chronic, non-curable conditions, treatment should be indefinite and only the loss of efficacy or the appearance of serious side effects may cause withdrawal. As regards to efficacy and their maintenance over time, evidence supports the continuous usefulness of the drug in the long term: in fact its withdrawal very substantially increases the risk of relapse. About side effects, azathioprine is a relatively well tolerated drug and even indefinite use seems safe. The main theoretical risks of prolonged use would be the myelotoxicity, hepatotoxicity, and the development of cancer. In fact, serious bone marrow suppression or serious liver damage are uncommon, and can be minimized with proper use of the drug. Recent metanalysis suggests that the risk of lymphoma is real, but the individual risk is rather low, and decision analysis suggests a favorable benefit/risk ratio in the long term. Therefore, in patients with inflammatory bowel diseases in whom azathioprine is effective and well tolerated, the drug should not be stopped. This recommendation concerns the use of azathioprine as a single maintenance drug, and is not necessarily applicable to patients receiving concomitant biological therapy.

  9. Enkeltcenteropgorelse af nyretransplanterede patienters nyrefunktion og immunsuppressive behandling

    DEFF Research Database (Denmark)

    Frederiksen, A.M.; Ewers, B.; Gasbjerg, A.; Marckmann, P.; Hansen, Jesper Melchior

    2008-01-01

    (74%) were treated with triple-drug immunosuppression, in most cases (46%) with the combination prednisolone-ciclosporine-azathioprine. During recent years, azathioprine has been increasingly replaced by mycophenolate mofetil. CONCLUSIONS: The majority of kidney-transplanted patients with a...

  10. Mødet med patienten og kulturen i psykiatrien8

    DEFF Research Database (Denmark)

    Mark, Edith

    2012-01-01

    kan indebære at behandle en patient med en psykisk lidelse ligeværdigt og som person. Teksten kommer også ind på begrebet "urørlighedszoner" som udtryk for det meget konkrete og private råderum, som mennesker, der har opnået en vis alder, tager for givet. Teksten giver eksempler på krænkelser af...

  11. Behandling med dopaminagonister og udvikling af hjerteklapsygdom hos patienter med hyperprolaktinæmi

    DEFF Research Database (Denmark)

    Steffensen, Maria Charlotte; Mægbæk, Merete Lund; Laurberg, Peter;

    2014-01-01

    Treatment with dopamin agonists, particularly cabergoline, is the primary and preferred therapy for prolactinomas and symptomatic hyperprolactinaemia due to its effectiveness and tolerability. However, an association has been demonstrated between fibrotic heart valve disease and high-dose dopamin...

  12. Angioneurotisk ødem i forbindelse med behandling med angiotensinkonverterende enzym-haemmer

    DEFF Research Database (Denmark)

    Johansen, E C; Johansen, J B; Døssing, H

    1996-01-01

    Angioneurotic oedema secondary to angiotensin-converting enzyme (ACE) inhibitors is a rare condition, but it is a side effect which is likely to be seen more frequently because of the increased use of these drugs in the treatment of heart failure and hypertension. We report two cases which...... illustrate problems in the diagnosis and management of this life-threatening condition, and also demonstrate that angioedema re-occurs if the ACE inhibitor is not discontinued. If angioedema is suspected, therapy with any angiotensin converting-enzyme inhibitor should be discontinued promptly, respiratory...

  13. Spectrophotometric determination of azathioprine in pharmaceutical formulations.

    Science.gov (United States)

    Lakshmi, C S; Reddy, M N

    1998-12-01

    Four simple and sensitive visible spectrophotometric methods (A-D) have been described for the assay of azathioprine (ATP) either in pure form or in pharmaceutical formulations. Methods A and B are based on the oxidation of ATP with excess N-bromosuccinimide (NBS) or chloramine-T (CAT) and determining the consumed NBS or CAT with a decrease in colour intensity of celestine blue (CB) (method A) or gallocyanine (GC) (method B), respectively. Methods C and D are based on the diazotisation of reduced azathioprine (RATP) with excess nitrous acid and estimating either the consumed nitrous acid (HNO(2)) with cresyl fast violet acetate (CFVA) (method C) or by coupling reaction of the diazonium salt formed with N-1-naphthyl ethylene diamine dihydrochloride (NED) (method D). All of the variables have been optimized and the reactions presented. The concentration measurements are reproducible within a relative standard deviation of 1.0%. Recoveries are 99.2-100.3%. PMID:18967434

  14. A placebo controlled, crossover study of azathioprine in Reiter's syndrome.

    OpenAIRE

    Calin, A

    1986-01-01

    Eight patients with intractable Reiter's disease were entered into a double blind, placebo controlled, crossover study of azathioprine versus placebo--each patient serving as his own control. Drug therapy was administered for 16 weeks, patients receiving azathioprine (eight weeks) or placebo (eight weeks) in random order. Azathioprine was given as 1 mg/kg body weight for the first month and 2 mg/kg body weight for the second month. Six individuals completed both arms of the crossover. One wit...

  15. Monitoring and Safety of Azathioprine Therapy in Inflammatory Bowel Disease

    OpenAIRE

    Kim, Mi Jin; Choe, Yon Ho

    2013-01-01

    Azathioprine is the most common drug used to maintain clinical remission in inflammatory bowel disease. This drug is also important as a steroid-sparing agent in steroid-dependent and chronically active inflammatory bowel disease. Nevertheless, many questions remain concerning the optimal treatment regimens of azathioprine. The dose of azathioprine has to be reduced or the therapy has to be discontinued frequently because of drug-induced toxicity. In this review, we discuss monitoring of thio...

  16. Randomised controlled trial of azathioprine withdrawal in ulcerative colitis.

    OpenAIRE

    Hawthorne, A. B.; Logan, R. F.; Hawkey, C. J.; Foster, P. N.; Axon, A T; Swarbrick, E T; Scott, B B; Lennard-Jones, J E

    1992-01-01

    OBJECTIVE--To determine whether azathioprine can prevent relapse in ulcerative colitis. DESIGN--One year placebo controlled double blind trial of withdrawal or continuation of azathioprine. SETTING--Outpatient clinics of five hospitals. SUBJECTS--79 patients with ulcerative colitis who had been taking azathioprine for six months or more. Patients in full remission for two months or more (67), and patients with chronic low grade or corticosteroid dependent disease (12) were randomised separate...

  17. Egenvård hos personer med typ 2 diabetes

    OpenAIRE

    Holmberg, Carina

    2012-01-01

    Bakgrund: Våra levnadsvanor har en central roll vid uppkomsten och utvecklandet av diabetes. Det primära vid vård av personer med typ 2 diabetes är att stödja egenvården. Målet med behandling av diabetes är att behålla en god livskvalitet samt förhindra komplikationer orsakade av sjukdomen. Syfte: Syftet var att undersöka den egenvård som personer med typ 2 diabetes utför. Metod: En kvalitativ intervjustudie med semistrukturerade frågor användes. Tio personer med typ 2 diabetes intervjuades....

  18. Hydrotermisk stabilitet av mikroporøse materialer med CHA topologi

    OpenAIRE

    Nilsen, Fredrik Bø

    2015-01-01

    Dette arbeidet har undersøkt to materialer, zeolitten SSZ-13 og det zeotype materialet SAPO-34, begge med CHA-topologi. Materialene ble syntetisert ut i fra tidligere utarbeidete prosedyrer før de ble hydrotermisk behandlet. Betingelsene under behandlingen var temperaturer på 600⁰C og 700⁰C med en konstant vanntilførsel på 6 ml/time over 4 timer. Før og etter behandling ble prøvene karakterisert med XRD, N2 adsorpsjon og BET beregninger, SEM, EDS, FT-IR med CO og pyridin som probemolekyler og...

  19. Pancytopenia due to the interaction of allopurinol with azathioprine or mercaptopurine.

    Science.gov (United States)

    2000-04-01

    (1) Allopurinol increases the haematological toxicity of azathioprine and mercaptopurine, with a risk of pancytopenia. (2) Combination of allopurinol with azathioprine or mercaptopurine should be avoided. PMID:11503788

  20. Utslåtte kvinner og oppegående menn – Rusmisbrukere i behandling

    Directory of Open Access Journals (Sweden)

    Abbi Vandeskog

    2009-10-01

    Full Text Available  SAMMENDRAGDenne undersøkelsen fokuserer på kjønnsforskjeller blant mannlige og kvinnelige misbrukere med hensyntil sosiodemografi, behandlingshistorie og rusmiddelmisbruk. 149 klienter (51 kvinner ble rekruttert fra enbehandlingsinstitusjon. Flere kvinner enn menn er uten arbeid, og lever på ulike former for sosial støtte.Relativt sett få kvinner har mottatt behandling for sitt rusproblem tidligere, inkludert avrusning. De harkortere misbrukskarrierer før de kommer til behandling, og drikker mindre alkohol enn menn. Imidlertid erflere av dem blandingsmisbrukere, hyppigst kombineres alkohol og benzodiazepiner.Vandeskog A, Skutle A. Gender differences among substance abusers in treatment.Nor J Epidemiol  ENGLISH SUMMARYThe present study focuses on gender differences regarding sociodemography, treatment history, andalcohol and drug use among male and female abusers. One hundred and forty-nine subjects (51 womenwere recruited from a clinical setting. More women than men are unemployed and living on different formsof social benefits. Relatively few women have been in treatment earlier, including detoxification units.They have shorter abuse careers before entering treatment, and consume less alcohol than men. Morewomen are multiple substance abusers, most frequently combining alcohol and benzodiazepines.1996; 6 (1: 115-122.

  1. [Panzytopenia from combination therapy with azathioprin and allopurinol].

    Science.gov (United States)

    Seidel, W

    2004-10-01

    Azathioprine has been used in rheumatology for more than twenty years. Indications are collagen diseases with multiorgan involvement, where co-medications are frequently necessary. We describe a patient suffering from pancytopenia following a combination therapy of azathioprine and allopurinol because of lupus erythematodes and diabetic nephropathy with hyperuricemia. PMID:15517303

  2. Side effects of azathioprine in patients with Crohn's disease.

    NARCIS (Netherlands)

    Jong, Dirk de; Goullet, M.; Naber, A.H.J.

    2004-01-01

    OBJECTIVE: In clinical trials 0-15% of patients discontinued azathioprine due to side effects. The aim of this study was to assess the rate of side effects leading to discontinuation of azathioprine and to determine predictive factors for discontinuation. DESIGN: A retrospective cohort analysis of c

  3. Erfaringer med intervensjonsforsøk i yrkesepidemiologi: Basert på studier av miljøtiltak for å forbedre inneklima i kontormiljø

    OpenAIRE

    Knut Skyberg; Knut Skulberg

    2009-01-01

     SAMMENDRAGBasert på to intervensjonsforsøk rettet mot helseeffekter i hud og øvre luftveier før og etter inneklimatiltak,drøftes erfaringer med design, metoder og analyse av data. Intervensjonene som ble prøvet ut varantistatisk behandling av dataskjerm (n=117) og storrengjøring i kontormiljø (n=104). Det ble måltstøvkonsentrasjon under vanlig arbeid med direktevisende partikkelteller. Ved støvkonsentrasjoner > 50μg/m 3 hadde tiltakene effekt. Antistatisk behandling av skjermen førte til red...

  4. Evaluering af forsøgsprojekter vedrørende psykologbehandling af personer med lette og moderat svære depressioner i Fyns og Åhus Amter

    DEFF Research Database (Denmark)

    Christensen, Kaj Aage Sparle

    tendens. Samlet set tyder evalueringen på, at personer med lette og moderate depressive enkeltepisoder behandles lige effektivt i privat og offentlig psykologordning. Henvisning til den gratis offentlige ordning var imidlertid forbundet med længere ventetid på behandling og længere varighed af eventuel...... I 2004 blev det i forbindelse med overenskomstforhandlinger mellem Sygesikringens Forhandlingsudvalg og Dansk Psykologforening aftalt at afholde udgifterne til evaluering af to 1-årige forsøg med behandling af personer med lette og moderate depressioner i Århus og Fyns Amter. Behandlingstilbudet...... der en gradvis forøgelse af ventetiden på behandling i begge amter, mest udtalt i Århus. Den gennemsnitlige ventetid på behandling var 25.3 dage på Fyn og 51.2 dage i Århus. Tilsvarende var patienterne gennemsnitligt sygemeldt 83.8 dage på Fyn og 117.5 dage i Århus Amt. Patienterne på Fyn modtog i...

  5. Att leva med bipolär sjukdom : En litteraturstudie om patienters erfarenheter av att leva med bipolär sjukdom

    OpenAIRE

    Andersson, Linda; Lövström, Jennifer

    2015-01-01

    Bakgrund: Bipolär sjukdom är en kronisk sjukdom som karaktäriseras utav förändringar i patientens aktivitetsnivå och stämningsläge. Dessa episoder benämns som mani-, hypomani- och depressionsepisoder. Behandling och omvårdnad fokuseras på att lindra symtom. Syfte: Syftet med denna litteraturstudie var att belysa patienters erfarenheter av att leva med bipolär sjukdom. Metod: I litteraturstudien användes 8 kvalitativa vetenskapliga artiklar. Dessa har sammanställts och analyserats med inspirat...

  6. KBT behandling inom ramen för Rehabgarantin, uppfattning och upplevelser hos behandlare och patienter i primärvården, Jämtland

    OpenAIRE

    Reslegård, Christina

    2010-01-01

    En stor del (uppskattningsvis 30%) av primärvårdens patienter lider av psykisk ohälsa. Genom införandet av Rehabgarantin garanteras personer med ångest och depression evidensbaserad samtalsbehandling bland annat i form av kognitiv beteendeterapi. En enkätundersökning visar att behandlare inom primärvården i Jämtland ger en behandling som influeras av andra terapeutiska inriktningar tillsammans med KBT och att de anser att KBT i sig är en alltför begränsad metod för att möta behoven hos primär...

  7. Weekly azathioprine pulse versus daily azathioprine in the treatment of Parthenium dermatitis: A non-inferiority randomized controlled study

    Directory of Open Access Journals (Sweden)

    Kaushal K Verma

    2015-01-01

    Full Text Available Background: Azathioprine in daily doses has been shown to be effective and safe in the treatment of Parthenium dermatitis. Weekly pulses of azathioprine (WAP are also effective, but there are no reports comparing the effectiveness and safety of these two regimens in this condition. Aims: To study the efficacy and safety of WAP and daily azathioprine in Parthenium dermatitis. Methods: Sixty patients with Parthenium dermatitis were randomly assigned to treatment with azathioprine 300 mg weekly pulse or azathioprine 100 mg daily for 6 months. Patients were evaluated every month to assess the response to treatment and side effects. Results: The study included 32 patients in the weekly azathioprine group and 28 in the daily azathioprine group, of whom 25 and 22 patients respectively completed the study. Twenty-three (92% patients on WAP and 21 (96% on daily azathioprine had a good or excellent response. The mean pretreatment clinical severity score decreased from 26.4 ± 14.5 to 4.7 ± 5.1 in the WAP group, and from 36.1 ± 18.1 to 5.7 ± 6.0 in the daily azathioprine group, which was statistically significant and comparable (P = 0.366. Patients on WAP had a higher incidence of adverse effects (P = 0.02. Limitations: The study had a small sample size and the amount of clobetasol propionate used in each patient was not determined, though it may not have affected the study outcome due to its comparable use in both groups. Conclusions: Azathioprine 300 mg weekly pulse and 100 mg daily dose are equally effective and safe in the treatment of Parthenium dermatitis.

  8. Pasienter med tannbehandlingsvegring : en analyse av dagens tilbud i Aust-Agder med forslag til forbedringer, spesielt med tanke på innføring av dyp sedasjon som behandlingsmetode

    OpenAIRE

    2012-01-01

    Det finnes et ikke ubetydelig antall pasienter med tannbehandlingsvegring i Norge. Disse pasientene har ikke noe reelt behandlingstilbud innenfor det offentlige helsevesenet i dag. Vi har kartlagt omfanget av tannbehandlingsvegring og behov for et styrket tilbud til disse pasientene ved hjelp av et spørreskjema sendt ut til samtlige tannleger i Aust-Agder. Omfanget av behandlingsvegring tilsvarer i vår studie omtrent omfanget av dette i andre studier fra inn-og utland. Tannlegenes behandl...

  9. Azathioprine-induced Sweet's syndrome and published work review.

    Science.gov (United States)

    Choonhakarn, Charoen; Chaowattanapanit, Suteeraporn

    2013-04-01

    Hypersensitivity to azathioprine can manifest with a wide clinical spectrum. Azathioprine-induced Sweet's syndrome (SS) is rare and usually overlooked because it can mimic disease exacerbation and sepsis. This study aims to characterize the clinical findings of azathioprine-induced SS. A retrospective analysis of the records of three patients diagnosed with azathioprine-induced SS and a review of the relevant English-language published work was performed. Twelve (71%) of the 17 patients were male, ranging 9-89 years in age (mean, 47.2). The time of onset after starting azathioprine was 5-28 days (mean, 13.3). The most common associated disease was inflammatory bowel disease including ulcerative colitis and Crohn's disease (76%). The clinical features typically consisted of fever and classic rash of SS with pustules and vesicles. The lesions occurred most commonly on the face and trunk. Systemic involvement was rare and no hypotension or shock was reported as seen in azathioprine hypersensitivity syndrome. Thiopurine methyltransferase activity is not predictive of this type of adverse effect. Most patients dramatically responded to systemic corticosteroids. Azathioprine-induced SS may be underdiagnosed because it can be easily misinterpreted as inflammatory bowel disease-associated skin eruption. Patients with inflammatory bowel disease may be at higher risk of this condition. Early recognition and drug withdrawal can decrease morbidity of the patients. PMID:23294021

  10. Hjemtagning af dialysebehandling til grønlandske patienter med kronisk nyresvigt

    DEFF Research Database (Denmark)

    Kronborg, Christian; Kjær, Trine; Bech, Mickael

    Dronning Ingrids Hospital i Nuuk kan organiseres, herunder foreslået hvordan en enhed ved Dronning Ingrids Hospital kan samarbejde med Rigshospitalet i København om behandlingen af patienter med behov for dialyse. Det foreslås således, at opstart af dialysebehandlingen, som nu, skal foregå på...... Rigshospitalet, hvorefter behandling og kontrol foregår på Dronning Ingrids Hospital. På baggrund af danske data om forekomsten af behandlingskrævende nyresvigt vurderes det, at der i dag er færre grønlandske patienter i dialysebehandling end forventet. En hjemtagning af behandlingen kan muligvis ændre på dette...... andelen overstige 60 % (mod ca. 40 % i dag). Hvis andelen af patienter med behov, som faktisk tager imod behandling, fastholdes over de næste 10 år, hvis behandlingen fortsat skal foregå som nu (ca. 40 %), mens andelen øges ved en hjemtagning, vil behandling på Dronning Ingrids Hospital være forbundet med...

  11. PTCH mutations in basal cell carcinomas from azathioprine-treated organ transplant recipients

    OpenAIRE

    Harwood, C.A.; Attard, N R; O'Donovan, P.; Chambers, P; Perrett, C. M.; Proby, C M; McGregor, J. M.; Karran, P.

    2008-01-01

    The immunosuppressant azathioprine is used to prevent graft rejection after organ transplantation. To investigate whether azathioprine-associated mutagenesis contributes to the high incidence of skin tumours in organ transplant recipients (OTRs), we analysed PTCH gene mutations in 60 basal cell carcinomas (BCC); 39 from OTRs receiving azathioprine and 21 from individuals never exposed to azathioprine. PTCH was mutated in 55% of all tumours, independent of azathioprine treatment. In both the a...

  12. Histiocytoid Sweet syndrome treated with azathioprine: a case report.

    Science.gov (United States)

    Miller, Jonathan; Lee, Nicole; Sami, Naveed

    2015-01-01

    Histiocytoid Sweet syndrome (HSS) is a rare histologic variation of Sweet syndrome (SS) predominantly exhibiting mononuclear histiocytoid cells instead of neutrophils. We report a 22-year-old woman with HSS, who, after minimal improvement with colchicine and dapsone, had significant improvement of her cutaneous eruption and systemic symptoms following empiric treatment with azathioprine. Since azathioprine has historically been known to cause SS, this case highlights a previously unreported treatment response for the histiocytoid variant. PMID:26436977

  13. Histiocytoid Sweet syndrome treated with azathioprine: a case report

    OpenAIRE

    Miller, Jonathan; Lee, Nicole; Sami, Naveed

    2015-01-01

    Histiocytoid Sweet syndrome (HSS) is a rare histologic variation of Sweet syndrome (SS) predominantly exhibiting mononuclear histiocytoid cells instead of neutrophils. We report a 22-year-old woman with HSS, who, after minimal improvement with colchicine and dapsone, had significant improvement of her cutaneous eruption and systemic symptoms following empiric treatment with azathioprine. Since azathioprine has historically been known to cause SS, this case highlights a previously unreported t...

  14. Controlled trial of azathioprine in chronic ulcerative colitis.

    OpenAIRE

    Kirk, A P; Lennard-Jones, J E

    1982-01-01

    A double-blind controlled trial of azathioprine in a dose of 2-2.5 mg/kg body weight over six months was conducted among 44 patients with active chronic ulcerative colitis. Three patients treated with placebo did not complete the trial because their disease became so severe that colectomy was performed. Among patients who completed the trial the mean dose of prednisolone necessary to control the disease decreased in those treated with azathioprine and those treated with placebo; the reduction...

  15. Effect of interleukin-2 on the inhibition of the human mixed lymphocyte reaction (MLR) by azathioprine.

    OpenAIRE

    Szawlowski, P W; Maddocks, J L

    1985-01-01

    The effect of interleukin-2 on the response of the human MLR to azathioprine was studied. Azathioprine (36 microM) inhibited the MLR by 86% and interleukin-2 (25%) stimulated the MLR by 99%. Only partial relief (16%) of azathioprine (36 microM) inhibition was found in the interleukin-2 treated MLR compared with azathioprine treatment alone. However, [3H]-thymidine incorporation by azathioprine (36 microM) + interleukin-2 treated MLR was 4.3 times greater than that exposed to azathioprine alon...

  16. Musikterapi med personer med demens

    DEFF Research Database (Denmark)

    Ridder, Hanne Mette Ochsner

    2014-01-01

    Musikterapi er forholdsvist velkendt i forhold til mennesker med neurologiske problemstillinger som erhvervet hjerneskade eller demens. Delkapitlet her giver et bredt helserelateret og udviklingspsykologisk perspektiv på neurologiske problemstillinger som følge af forandringer i hjernen. Derfor i...

  17. Early pregnancy azathioprine use and pregnancy outcomes.

    LENUS (Irish Health Repository)

    Cleary, Brian J

    2012-02-01

    BACKGROUND: Azathioprine (AZA) is used during pregnancy by women with inflammatory bowel disease (IBD), other autoimmune disorders, malignancy, and organ transplantation. Previous studies have demonstrated potential risks. METHODS: The Swedish Medical Birth Register was used to identify 476 women who reported the use of AZA in early pregnancy. The effect of AZA exposure on pregnancy outcomes was studied after adjustment for maternal characteristics that could act as confounders. RESULTS: The most common indication for AZA use was IBD. The rate of congenital malformations was 6.2% in the AZA group and 4.7% among all infants born (adjusted OR: 1.41, 95% CI: 0.98-2.04). An association between early pregnancy AZA exposure and ventricular\\/atrial septal defects was found (adjusted OR: 3.18, 95% CI: 1.45-6.04). Exposed infants were also more likely to be preterm, to weigh <2500 gm, and to be small for gestational age compared to all infants born. This effect remained for preterm birth and low birth weight when infants of women with IBD but without AZA exposure were used as a comparison group. A trend toward an increased risk of congenital malformations was found among infants of women with IBD using AZA compared to women with IBD not using AZA (adjusted OR: 1.42, 95% CI: 0.93-2.18). CONCLUSIONS: Infants exposed to AZA in early pregnancy may be at a moderately increased risk of congenital malformations, specifically ventricular\\/atrial septal defects. There is also an increased risk of growth restriction and preterm delivery. These associations may be confounded by the severity of maternal illness.

  18. An audit of thiopurine methyltransferase genotyping and phenotyping before intended azathioprine treatment for dermatological conditions

    DEFF Research Database (Denmark)

    Vestergaard, T; Bygum, A

    2009-01-01

    Summary Background. Determining thiopurine methyltransferase (TPMT) genotype and phenotype before azathioprine treatment predicts which patients are most likely to develop myelosuppression. Aim. To evaluate the course of azathioprine treatment in people with TPMT heterozygosity and whether this d...

  19. Azathioprine with prednisone for polymyositis. A controlled, clinical trial.

    Science.gov (United States)

    Bunch, T W; Worthington, J W; Combs, J J; Ilstrup, D M; Engel, A G

    1980-03-01

    A controlled, prospective, double-blind, therapeutic trial of azathioprine was conducted in the initial therapy of polymyositis. Sixteen patients received 60 mg prednisone per day plus either azathioprine (2 mg/kg of body weight per day) or placebo for a period of 3 months. Creatine phosphokinase (CPK) levels fell to normal slightly sooner in the placebo group, but not significantly so. The azathioprine group did not become significantly stronger (P = 0.58) and did not manifest significantly greater improvement of histopathologic features of muscle (P = 0.80) than the placebo group. Initial CPK elevations were significantly related to the degree of muscle inflammation (P = 0.037), but this was not the case at 3 months (P greater than 0.05). Normalization of the CPK could not be equated with disease control. Type II fiber atrophy, attributed to steroid therapy, was more marked in women than in men (P less than 0.03). PMID:6986827

  20. Treatment of Crohn's disease recurrence after ileoanal anastomosis by azathioprine.

    Science.gov (United States)

    Berrebi, W; Chaussade, S; Bruhl, A L; Pariente, A; Valleur, P; Hautefeuille, P; Couturier, D

    1993-08-01

    Ileoanal anastomosis is a surgical procedure performed in patients with ulcerative colitis. In a small number of patients operated on for ulcerative colitis, Crohn's disease occurs in the reservoir, mimicking pouchitis, and may lead to pouch excision and to a permanent terminal ileostomy. Two patients with recurrent Crohn's disease in the reservoir after ileoanal anastomosis were treated with azathioprine for 18 and 24 months, respectively. Azathioprine induced a complete clinical and endoscopic remission. These two observations suggested that immunosuppressive drugs were a good option for permanent ileostomy in cases of recurrence of Crohn's disease in the reservoir after ileoanal anastomosis. PMID:8344116

  1. Biochemical and morphological study on hepatotoxicity of azathioprine in rat.

    Directory of Open Access Journals (Sweden)

    Watanabe,Akiharu

    1979-02-01

    Full Text Available Sprague-Dawley rats given azathioprine in the diet for 3 to 4 weeks developed severe liver damage. Elevations of serum alkaline phosphatase and gamma-glutamyl transpeptidase activities were associated with increased hepatic glucose 6-phosphate dehydrogenase levels and decreased liver glucose 6-phosphatase activities, i.e., conditions which were commonly observed in various hepatotoxin-induced liver injuries. Light and electron microscopic observations revealed centrolobular necrosis with large scars and the proliferation of the mitochondria and rough endoplasmic reticulum. This model could be used to study the mechanisms of azathioprine-induced liver damage and its prevention.

  2. Risk of non-melanoma skin cancer in myasthenia patients treated with azathioprine

    DEFF Research Database (Denmark)

    Pedersen, E G; Pottegård, A; Hallas, J;

    2014-01-01

    The association between use of azathioprine and risk of non-melanoma skin cancer (NMSC) in patients with myasthenia was evaluated in a nationwide setting. Treatment of autoimmune myasthenia frequently involves long-term exposure to immunosuppressants, including azathioprine. Use of azathioprine...

  3. Attenuation of murine graft-versus-host reactivity by azathioprine

    Energy Technology Data Exchange (ETDEWEB)

    Shand, F.L.

    1980-07-01

    The therapeutic effects of azathioprine were evaluated in a murine graft-versus-host (GVH) model. A single high dose (200 mg/kg) of azathioprine, administered to FI recipients 2 to 3 days after the injection of parental spleen cells, abrogated the ensuing GVH reaction. Lower doses of the drug, even when injected over an extended period of time (14 days), were found to be ineffective. However, high doses of azathioprine failed to protect when FI recipients were sublethally irradiated or injected with cyclophosphamide before GVH induction, and even the transfer of syngeneic FI spleen cells immediately after irradiation failed to alter this outcome. Further analysis of the changes that occurred in sublethally irradiated recipients revealed that the protective effect of azathioprine on CBA leads to (CBA x C57BL)FI GVH reaction was totally abrogated by doses of irradiation as low as 200 rad. Further experiments in which death was used as an indicator of GVH disease showed that lethality could not be reversed in sublethally irradiated FI recipients by the transfer of syngeneic FI spleen cells unless approximately 10 days were allowed to elapse between syngeneic reconstitution and GVH induction. Since syngeneic FI cells from spleen, lymph node, or bone marrow all behaved similarly, it seems likely that the increased severity of GVH reaction induced by prior immunosuppression may not be attributable to a simple cell deletion event.

  4. Attenuation of murine graft-versus-host reactivity by azathioprine

    International Nuclear Information System (INIS)

    The therapeutic effects of azathioprine were evaluated in a murine graft-versus-host (GVH) model. A single high dose (200 mg/kg) of azathioprine, administered to FI recipients 2 to 3 days after the injection of parental spleen cells, abrogated the ensuing GVH reaction. Lower doses of the drug, even when injected over an extended period of time (14 days), were found to be ineffective. However, high doses of azathioprine failed to protect when FI recipients were sublethally irradiated or injected with cyclophosphamide before GVH induction, and even the transfer of syngeneic FI spleen cells immediately after irradiation failed to alter this outcome. Further analysis of the changes that occurred in sublethally irradiated recipients revealed that the protective effect of azathioprine on CBA leads to (CBA x C57BL)FI GVH reaction was totally abrogated by doses of irradiation as low as 200 rad. Further experiments in which death was used as an indicator of GVH disease showed that lethality could not be reversed in sublethally irradiated FI recipients by the transfer of syngeneic FI spleen cells unless approximately 10 days were allowed to elapse between syngeneic reconstitution and GVH induction. Since syngeneic FI cells from spleen, lymph node, or bone marrow all behaved similarly, it seems likely that the increased severity of GVH reaction induced by prior immunosuppression may not be attributable to a simple cell deletion event

  5. Primary CNS lymphoma in a patient treated with azathioprine

    DEFF Research Database (Denmark)

    Glesner, Matilde Kanstrup; Ocias, Lukas Frans; Larsen, Thomas Stauffer; Pedersen, Court

    2014-01-01

    A 33-year-old man treated with azathioprine for 12 years for Crohn's disease presented with headache, nausea and vomiting accompanied by difficulty in putting words together and slight mental confusion. Prednisolone and antibiotics were without effect. MRI of the brain showed multiple focal lesions...

  6. Kan ullfrotté lindra de strålrelaterade hudbiverkningarna vid behandling av bröstcancer?

    OpenAIRE

    Bylund, Jennie; Johansson, Charlotte

    2015-01-01

    Syfte. Att jämföra strålrelaterade hudbiverkningar efter behandling av bröstcancer mellan kvinnor som använt en nyutvecklad bh innehållande ullfrotté, och kvinnor som inte använt bhn. Bakgrund. Bröstcancer är den vanligaste cancerdiagnosen för kvinnor i världen, där behandlingen främst utgörs av kirurgi med kompletterande cytostatika- och strålbehandling. En av de vanligaste biverkningarna vid strålbehandling är hudreaktioner. Design. Kvantitativ deskriptiv tvärsnittsstudie. Metod. Enkätstud...

  7. Mulig forbedret behandling af kolorektal cancer med sentinel lymph node-diagnostik

    DEFF Research Database (Denmark)

    Burgdorf, Stefan K; Eriksen, Jens Ravn; Gögenür, Ismail

    2014-01-01

    Possibly improved treatment of colorectal cancer by sentinel lymph node mapping Prognosis for colorectal cancer is dependent on radical surgical intervention. Chemotherapy in patients with advanced disease has improved the survival. A considerable proportion of the patients going through radical...... surgery will subsequently relapse. Adjuvant chemotherapy is reserved for patients with lymph node metastases, why undetected malignant lymph nodes will result in understaging and exclusion from the possible benefit of adjuvant chemotherapy. With sentinel lymph node mapping it may be possible to detect and...

  8. Et Patientperspektivistisk Studie i Brug af Alternativ Behandling hos Danske Patienter med Diabetes

    DEFF Research Database (Denmark)

    Gerbild, Helle Nygaard

    2008-01-01

    or cure, and the specific type of CAM used. The experiences of the patients were connected with these factors. The results of this study are that infrequent clients are not positioned towards CAM specificly for diabetes. The established clients using CAM were posited towards CAM supplying...... established clients, however, are positioned as user of both complementary and alternative medicine and conventional treatments, such as biological, homeopathic, and traditional Chinese medicine. The main factors that drive them to this are the aim, the hope, the belief, and knowledge how to cure diabetes....... Conclusion: The study shows that the decisive difference of how diabetics are positioned as to complementary and alternative self-care is the way in which they have the strength and hope, believe and knowledge of how to cure disease which by people in general is regarded as chronic....

  9. Hjertestop forårsaget af massiv lungeemboli under behandling med tranexamsyre

    DEFF Research Database (Denmark)

    Gybel, Mikkel; Kristensen, Kjeld; Roseva-Nielsen, Natasha

    2013-01-01

    Pulmonary embolism (PE) as the direct cause of cardiac arrest is well known but probably under-diagnosed. Treatment of menorrhagia with antifibrinolytics is a well documented treatment modality and it is considered safe although thromboembolic complications have been reported. We describe a case of...

  10. Kost og Idræt til behandling af børn med ADHD

    OpenAIRE

    Thorsdal-Hjeds, Michala Lykke; Lund, Kira; Elling, Fenja Sidse Rudkjøbing; Nielsen, Sif Hummelgaard

    2014-01-01

    Ritalin is the most common medication used for attention deficit hyperactivity disorder (ADHD) and figures show a radical increase in the production of this particular drug within the last decade, leading to the conclusion that more people - especially children showing erratic behavior - are being diagnosed with ADHD and treated for it medically. In opposition to this development of medicating an increasing number of children, this report focuses upon diet and exercise as alternative metho...

  11. Svær laryngomalaci hos børn kan behandles med laserkirurgi

    DEFF Research Database (Denmark)

    Meyer, Lars Christian; Godballe, Christian

    2012-01-01

    Laryngomalacia is the most common cause for congenital stridor. The stridor is caused by collapse of supraglottic structures during inspiration. Two severe cases treated with laser-assisted supraglottoplasty are presented. Our cases as well as the literature describe good effect of the treatment...

  12. Behandling og diagnostik af tuberkulose: fremad med små skridt

    DEFF Research Database (Denmark)

    Andersen, Ase Bengård; Lillebæk, Troels; Bang, Didi;

    2011-01-01

    Development of new drugs for the treatment of drug sensitive and drug resistent tuberculosis is badly needed. Substantial progress has been made in the field and presently six new drug components are in clinical phase I and II trials. Drugs approved for other indications e.g. newer fluoroquinolones...

  13. Udredning og behandling af osteoporose hos patienter med prostatacancer uden knoglemetastaser

    DEFF Research Database (Denmark)

    Eiken, Pia Agnete; Langdahl, Bente Lomholt; Eiken, Frederik L;

    2011-01-01

    The prevention of cancer treatment-induced bone loss in patients with prostate cancer due to gonadotropin-releasing hormone (GnRH)-agonist, GnRH-antagonist and orchidectomi therapy has a high priority. We present an algorithm for the prevention and treatment of osteoporosis during treatment of non......-metastatic prostate cancer....

  14. Effekt af trombolytisk behandling på udfaldet af tidlig arbejdstest hos patienter med akut myokardieinfarkt

    DEFF Research Database (Denmark)

    Svendsen, Jesper Hastrup; Madsen, J K; Saunamäki, K I;

    1994-01-01

    , systolic blood pressure and rate-pressure product were similar in the two groups. At maximum workload the streptokinase treated patients had a significantly higher median maximal heart rate than controls (136 vs. 126 min-1; p <0.01) but only a trend towards higher systolic blood pressure was seen (175 vs....... 163 mmHg; p = 0.09). Rate-pressure product at maximal exercise was 23.620 vs. 20.100 mmHg x min-1; p <0.01). A significantly smaller number of patients in the streptokinase group had exercise capacity below 50 W (0% vs. 15.9%; p <0.01). In conclusion: patients treated with intravenous streptokinase...... for acute myocardial infarction reach both higher heart rates and rate-pressure products at maximum workload than their controls thus indicating that the beneficial effects of thrombolysis after acute myocardial infarction are reflected in an improved heart rate response during exercise....

  15. Organisation af behandling og opfølgning af patienter med type 2-diabetes

    DEFF Research Database (Denmark)

    Drivsholm, Thomas Bo; Snorgaard, Ole

    2012-01-01

    The organization of treatment and control of type 2 diabetic patients in Denmark has undergone a major development within the last decade. From being based on local hospital guidelines, treatment and control have moved towards a more organized collaboration between primary and secondary care based...... on common national guidelines. Quality indicators from primary and secondary care are collected routinely, and gradually an increasingly precise depiction is documented in the National Indicator Project....

  16. Terapeuters forståelse og behandling av pasienter med psykose: en kvalitativ studie.

    OpenAIRE

    Due-Tønnessen, Maria; Erdal-Aase, Ragna

    2007-01-01

    This is a qualitative study based on interviews with 12 psychotherapists, that each have significant experience of individual psychotherapy with patients with psychosis. The aim of the study is to examine how psychosis is understood and how patients with psychosis are currently treated by therapists in Norway. The interviews were analysed using hermeneutic-fenomenological methods with elements from Consensual Qualitative Research. The results show a broad range both in the therapists’ underst...

  17. Hvordan kan mindfulness-basert behandling hjelpe for pasienter med tinnitus?

    OpenAIRE

    Valle, Linda

    2014-01-01

    Tinnitus is a common and severe disorder presenting big health issues for the many people affected. The fact that not all people are affected by their tinnitus, have been a puzzle for scientists. This has led to an expanded psychological view of tinnitus over time. Tinnitus as a functional disorder, is first of all a medical disorder, and treatment has been oriented from an audiological perspective. Studies and neurophysiology has shown tinnitus to be a transdiagnostic disorder, which mean th...

  18. Akut iliofemoral venøs trombose bør behandles med kateterbaseret trombolyse

    DEFF Research Database (Denmark)

    Broholm, Rikke; Just, Sven; Jørgensen, Maja; Bækgaard, Niels

    2012-01-01

    Treatment of acute iliofemoral deep venous thrombosis (DVT) with catheter-directed thrombolysis (CDT) has been performed in Denmark since 1999. The purpose of CDT is to dissolve thrombus and to restore the venous lumen as fast as possible and thereby save venous valve function and prevent...... postthrombotic syndrome. Danish studies have shown that treatment of acute iliofemoral DVT using CDT results in good patency, preserves venous valve function, reduces the frequency of PTS, and is associated with a higher quality of life....

  19. Behandling af kardiogent shock med perkutan mekanisk cirkulationsstøtte

    DEFF Research Database (Denmark)

    Junker, Anders; Kaltoft, Anne; Hassager, Christian; Christensen, Erika; Lippert, Freddy; Ravn, Hanne Berg; Eiskjær, Hans; Tilsted, Hans-Henrik; Schmidt, Henrik; De Haas, Inge; Møller, Jacob Eifer; Ravkilde, Jan; Lassen, Jens Flensted; Wachtell, Kristian; Holmvang, Lene; Jensen, Lisette Okkels; Greve, Matias Lindholm; Engstrøm, Thomas

    2013-01-01

    Despite rapid revascularisation with circulatory support using inotropes and intra-aortic balloon counterpulsation, the mortality of cardiogenic shock complicating acute myocardial infarction still exceeds 50%. An alternative treatment strategy is restoration of cardiac output by using a ventricu...

  20. Screening for tuberkuloseinfektion før behandling med biologiske lægemidler

    DEFF Research Database (Denmark)

    Ravn, Pernille

    2011-01-01

    Tumour necrosis factor antagonists (anti-TNFα) have become an invaluable treatment against chronic inflammatory diseases. Individuals treated with anti-TNFα have more than a fourfold increased risk of tuberculosis (TB) reactivation depending on the clinical setting and the TNF-antagonist used. All...... candidates for anti-TNFα treatment in Denmark should be evaluated for possible latent TB using history of exposure, chest X-ray and an interferon-γ release assay. Preventive chemotherapy is recommended for all individuals with latent TB infection before initiation of anti-TNFα as it is expected to reduce the...

  1. Segmentel vending af tyndtarmen til behandling af voksne patienter med korttarms syndrom

    DEFF Research Database (Denmark)

    Burgdorf, Stefan K; Qvist, Niels; Gögenur, Ismail

    2014-01-01

    Short bowel syndrome is the result of extensive surgical resection, inherited defects or loss of functional absorbing intestine. Parenteral nutrition is associated with high economical expenses, increased morbidity and decreased quality of life. Intestinal transplantation is associated with high...... morbidity and mortality rates. Segmental reversal of the small bowel can prolong the transit time in the small bowel and in many cases permanently end parenteral nutrition dependency. Segmental reversal of the small bowel should be integrated in the surgical treatment of adults with short bowel syndrome....

  2. Sykepleiekompetanse -en kvalitativ studie om sykepleieres erfaringer i behandling av pasienter med diagnosen paranoid schizofreni

    OpenAIRE

    Bakland, Maria

    2014-01-01

    Background and purpose: Today's political guidelines show increased investment in mental health care. Many people with mental illness, who have lost their employability, report that they feel they have not been treated for their mental health problem. As a nurse working with the patient with a diagnosis of paranoid schizophrenia , one is mostly dependent on using oneself as an instrument. It is therefore important to be aware of one's own skills, and the ways in which competence will affect t...

  3. Manglende evidens for skadelig effekt på knogleheling ved behandling med NSAID

    DEFF Research Database (Denmark)

    Janum, Susanne; Kristensen, Billy Bjarne

    2012-01-01

    The use of NSAIDs for postoperative pain management following orthopaedic surgery or during conservative treatment of fractures is controversial. Experimental animal models suggest NSAIDs inhibit bone healing. In a review of the literature, there was no clinical evidence to support categorical...... discard of NSAID for postoperative pain relief in uncomplicated cases. However, NSAID should be considered a potentiel risk factor of impaired bone healing and avoided in patients with a high risk of pseudoarthrosis. Recommended daily doses should be respected and duration of treatment should be limited....

  4. Spædbørnsdiabetes kan ofte behandles med sulfonylurinstof i stedet for insulin

    DEFF Research Database (Denmark)

    Lauridsen, Mette Høj; Boesgaard, Trine Welløv; Pedersen, Oluf Borbye; Hansen, Torben; Hertz, Birgitte

    2009-01-01

    A two-month-old Danish girl was admitted to the hospital in diabetic ketoacidosis and diagnosed with permanent neonatal diabetes mellitus (PNDM). She received continuous insulin treatment until she was genetically tested at the Steno Diabetes Centre. She carried a KCNJ11 Arg201His mutation, an...... activating mutation in the KCNJ11-gene which encodes the ATP-sensitive potassium subunit Kir6.2 in the beta cell which is responsible for insulin secretion. As recommended in the literature, she was successfully shifted from insulin therapy to sulfonylurea tablets at the age of three years and nine months...

  5. Spaedbørnsdiabetes kan ofte behandles med sulfonylurinstof i stedet for insulin

    DEFF Research Database (Denmark)

    Lauridsen, Mette Høj; Boesgaard, Trine Welløv; Pedersen, Oluf; Hansen, Torben; Hertz, Birgitte

    2009-01-01

    A two-month-old Danish girl was admitted to the hospital in diabetic ketoacidosis and diagnosed with permanent neonatal diabetes mellitus (PNDM). She received continuous insulin treatment until she was genetically tested at the Steno Diabetes Centre. She carried a KCNJ11 Arg201His mutation, an...... activating mutation in the KCNJ11-gene which encodes the ATP-sensitive potassium subunit Kir6.2 in the beta cell which is responsible for insulin secretion. As recommended in the literature, she was successfully shifted from insulin therapy to sulfonylurea tablets at the age of three years and nine months...

  6. Behandling og diagnostik af tuberkulose: fremad med små skridt

    DEFF Research Database (Denmark)

    Andersen, Ase Bengård; Lillebæk, Troels; Bang, Didi; Prahl, Julie

    2011-01-01

    and oxazolidinones are also being assessed in human phase II and III trials. Efforts are made to develop easy-to-handle diagnostic tools that will allow early detection of potential MDR or XDR cases. The Xpert RIF/MTB is a prototype of such an invention. At long last the field is moving slowly forward....

  7. Azathioprine-induced bullous Sweet's syndrome: a rare association.

    Science.gov (United States)

    Biswas, Sugata Narayan; Chakraborty, Partha Pratim; Gantait, Kripasindhu; Bar, Chittaranjan

    2016-01-01

    A 52-year-old man presented with high-grade fever, headache and painful vesicular skin rash involving the upper trunk and upper extremities, 8 days after initiation of chemotherapy with azathioprine (50 mg/day), which had been prescribed for acral vitiligo. There was neither any history of preceding respiratory or gastrointestinal tract infection, nor was the patient known to have malignancy, drug hypersensitivity, inflammatory bowel disease, vasculitis or other autoimmune disease. Laboratory results revealed leucocytosis with neutrophilia and markedly elevated acute phase reactants. Antinuclear antibody, perinuclear and cytoplasmic antineutrophil cytoplasmic antibody were found negative. Punch biopsy from skin of the upper trunk revealed dense neutrophilic infiltration of dermis without signs of vasculitis, suggestive of Sweet's syndrome. In view of the temporal association with azathioprine and absence of an obvious alternative aetiology, provisional diagnosis of drug-induced bullous Sweet's syndrome was made. Azathioprine was discontinued and high-dose oral prednisolone initiated. The response was dramatic with resolution of skin lesions within 72 h without further recurrence at fourth week of follow-up. PMID:27090551

  8. Azathioprine Induced Pancreatitis in a Patient with Co-Existing Autoimmune Pancreatitis and Hepatitis

    Directory of Open Access Journals (Sweden)

    Preethi GK Venkatesh

    2011-05-01

    Full Text Available Context Azathioprine induced pancreatitis usually runs a benign self limited course with rapid disappearance of signs and symptoms upon with drawl of the drug. Azathioprine is used in treating relapses in patients with autoimmune pancreatitis and maintenance of remission in autoimmune hepatitis. Acute pancreatitis complicated by symptomatic pseudocysts requiring drainage is not usually associated with drug induced pancreatitis. The risk of azathioprine use in patients with underlying disease of pancreas including autoimmune pancreatitis is unclear. Case report We report here a case of an African American patient with co-existing autoimmune pancreatitis and autoimmune hepatitis who developed azathioprine induced acute pancreatitis complicated by a large symptomatic pseudocyst compressing the duodenum requiring a cystoduodenostomy. Conclusions Future studies to investigate the risk of azathioprine induced pancreatitis in the presence of underlying disease of the pancreas including autoimmune pancreatitis are required to further understand the safety of azathioprine in this sub group of patients.

  9. Azathioprine pharmacokinetics after intravenous, oral, delayed release oral and rectal foam administration.

    OpenAIRE

    Van Os, E C; Zins, B J; Sandborn, W J; Mays, D C; Tremaine, W J; Mahoney, D W; Zinsmeister, A R; Lipsky, J J

    1996-01-01

    BACKGROUND: 6-Mercaptopurine and its prodrug azathioprine are effective medications for refractory inflammatory bowel disease. However, use of these drugs has been limited by concerns about their toxicity. Colonic delivery of azathioprine may reduce its systemic bioavailability and limit toxicity. AIM: To determine the bioavailability of 6-mercaptopurine after administration of azathioprine via three colonic delivery formulations. METHODS: Twenty four healthy human subjects each received 50 m...

  10. Azathioprine-induced accelerated cutaneous and pulmonary nodulosis in a patient with rheumatoid arthritis*

    OpenAIRE

    Kellet, Cristian Vera; Navarrete, Romina Andino; Bombardieri, Sergio González; Manriquez, Juan

    2015-01-01

    We report the case of a 42-year-old female with a 5-year history of rheumatoid arthritis treated with Rituximab and Azathioprine. Three months after the initiation of Azathioprine, the patient started with dry cough and noted the rapid development of multiple subcutaneous nodules on her right leg. CT scan of the chest demonstrates pulmonary nodulosis. Skin biopsy was compatible with rheumatoid nodule. A diagnosis of "accelerated cutaneous and pulmonary nodulosis" was considered. Azathioprine ...

  11. Azathioprine Induced Pancreatitis in a Patient with Co-Existing Autoimmune Pancreatitis and Hepatitis

    OpenAIRE

    Preethi GK Venkatesh; Udayakumar Navaneethan

    2011-01-01

    Context Azathioprine induced pancreatitis usually runs a benign self limited course with rapid disappearance of signs and symptoms upon with drawl of the drug. Azathioprine is used in treating relapses in patients with autoimmune pancreatitis and maintenance of remission in autoimmune hepatitis. Acute pancreatitis complicated by symptomatic pseudocysts requiring drainage is not usually associated with drug induced pancreatitis. The risk of azathioprine use in patients with underlying disease ...

  12. A study of the utility of azathioprine metabolite testing in myasthenia gravis.

    Science.gov (United States)

    Rae, William; Burke, Georgina; Pinto, Ashwin

    2016-04-15

    Myasthenia gravis (MG) is an autoimmune neuromuscular disorder characterised by fatigable voluntary skeletal muscle weakness. The underlying pathogenesis is complex involving adaptive autoimmune responses. Azathioprine remains a first line broad acting immunosuppressant for MG. Due to varied clinical responses to azathioprine we aimed to investigate the relationship between azathioprine metabolites and symptom control. Mild correlations between Quantitative Myasthenia Gravis Score (QMG) vs. 6-thioguanine nucleotides (R=-0.317 p=0.186) and QMG vs. lymphocyte count (R=0.402 p=0.08) were found. Azathioprine metabolite measurement should be considered in MG patients with; pancytopenia, deranged liver function or recurrent infections. PMID:27049566

  13. Azathioprine suppresses the mixed lymphocyte reaction of patients with Lesch-Nyhan syndrome.

    OpenAIRE

    Szawlowski, P W; Al-Safi, S A; Dooley, T.; Maddocks, J L

    1985-01-01

    The mixed lymphocyte reaction of Lesch-Nyhan patients (HGPRT deficient) was used to study the immunosuppressive effects of azathioprine and 6-mercaptopurine (6-MP). Mitogen stimulated lymphocytes of these patients are highly resistant to azathioprine and 6-MP. When both stimulator and responder lymphocytes in the MLR were HGPRT deficient, azathioprine (36 microM) was much more inhibitory than 6-MP (100 microM). Azathioprine produced inhibition of 98.2% and 78.5% compared with the values of 63...

  14. Det Intelligente Hjem:Et Dansk Energi Producerende Eksperiment Designet med Dagslys

    OpenAIRE

    Hansen, Ellen Kathrine; Olesen, Gitte Gylling Hammershøj; Mullins, Michael

    2013-01-01

    Artiklen sætter fokus på mulighederne for at høste energi direkte fra solen ved brug af intelligente vinduer. Design og udvikling af intelligente teknologier integreret i vinduets design skaber unikke udfordringer og muligheder for at designe bygninger med de bedst mulige omgivelser for mennesker og natur. Gennem en tværfaglig tilgang behandles samspillet mellem dagslys defineret i tekniske termer og dagslys er defineret i æstetiske, arkitektoniske udtryk. Gennem feltstudier af et dansk CO2 n...

  15. En gjennomgang av Salten-pasienter med ST-elevasjonsinfarkt i perioden 2005-2006

    OpenAIRE

    Lien, Marie Renée; Torstensen, Renate

    2007-01-01

    Bakgrunn: Akutt ST-elevasjons infarkt er en livstruende tilstand som krever rask behandling. Mange forskningsmiljøer har jobbet med problemstillingen trombolyse eller PCI som revaskulariseringsstrategi. Akutt PCI er under like tidsforhold å foretrekke fremfor trombolyse. Nord-Norges geografi medfører at en stor del av infarktpasientene ikke vil nå invasivt senter innen tidsvinduet for primær PCI. Vi ønsket derfor å analysere tidsforsinkelser i ulike deler av kjeden, og se på hvordan problemst...

  16. Endring i adaptiv atferd hos eldre personer med utviklingshemning - en sammenligning mellom personer med Down syndrom og personer med annen utviklingshemning

    Directory of Open Access Journals (Sweden)

    Anne Marit Bygdnes

    2012-01-01

    Full Text Available Bakgrunn: Stadig flere personer med utviklingshemning oppnår høg alder. Endring i adaptiv atferd kan være et tidlig tegn på aldersrelaterte lideleser som Alzheimers sykdom. Studien belyser om screeningsinstrumentet ABDQ kan benyttes av omsorgspersoner for å avdekke endring i adaptiv atferd.Materiale og metode: Undersøkelsen omfatter 87 personer med utviklingshemning som tidligere har bodd på en sentralinstitusjon. Datainnsamling skjedde ved at omsorgspersoner fylte ut ABDQ.  Resultater: Det var 24 % i utvalget som hadde nedgang i adaptiv atferd. Fortolkning: ABDQ er et hjelpemiddel til å avdekke nedgang i adaptiv atferd. Det er viktig at svikt avdekkes tidligst mulig og videreformidles til helsepersonell for utredning, diagnostisering, relevant behandling og tilrettelagte helse- og omsorgstjenester. Mange personer med utviklingshemning mestrer ikke å informere om egen helsetilstand og er avhengig av at omsorgspersonalet kan avdekke sykdom og lidelser så tidlig som mulig i sykdomsforløpet.

  17. Use of azathioprine and the risk of cancer in inflammatory bowel disease

    DEFF Research Database (Denmark)

    Pasternak, Björn; Svanström, Henrik; Schmiegelow, Kjeld;

    2013-01-01

    %) used azathioprine) in Denmark from 1997 to 2008. We linked registry data on filled drug prescriptions, cancer diagnoses, and covariates and compared rates of overall incident cancer and cancer subgroups between users and nonusers of azathioprine, adjusting for propensity scores. During a median 7...

  18. Treatment of progressive renal failure and nephrotic syndrome with azathioprine and prednisolone.

    OpenAIRE

    Baker, L R; Tucker, B; Macdougall, I C; Oommen, R

    1997-01-01

    Four patients with idiopathic membranous glomerulonephritis, heavy proteinuria and progressive renal failure received azathioprine and prednisolone. Renal function improved in all four and proteinuria declined sharply in three. We suggest that treatment with azathioprine and prednisolone may be of benefit in this form of idiopathic membranous glomerulonephritis.

  19. MedSun Reports

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Medical Product Safety Network (MedSun) is an adverse event reporting program launched in 2002. The primary goal for MedSun is to work collaboratively with the...

  20. Azathioprine therapy for acquired myasthenia gravis in five dogs.

    Science.gov (United States)

    Dewey, C W; Coates, J R; Ducoté, J M; Meeks, J C; Fradkin, J M

    1999-01-01

    Five dogs with acquired myasthenia gravis (MG), verified via positive serum acetylcholine (ACh) receptor antibody concentrations, were treated with a drug protocol including azathioprine (AZA). Four of the five dogs were concurrently treated with pyridostigmine. Azathioprine was used as the sole immunosuppressive agent in four dogs. One dog was temporarily treated with a combination of an immunosuppressive dose of prednisone and AZA, then maintained on AZA as the sole immunosuppressive drug. Three patients experienced complete remission of clinical signs within three months of therapy. In the four dogs for which follow-up serum ACh receptor antibody concentrations were available, initial versus final concentrations decreased substantially (81%), coincident with clinical improvement. One dog died suddenly due to a suspected myasthenic crisis before attaining the target dose of AZA. Two of the four surviving dogs were euthanized approximately one and seven years after diagnosis. One of these two dogs was euthanized because of a rib osteosarcoma, and the other dog was euthanized because of paraparesis of undetermined cause. The remaining two dogs were alive and doing well at the time of final follow-up evaluation, approximately six months and one year after diagnosis. The use of AZA as a therapeutic agent for acquired canine MG has not been investigated. The cases presented in this report suggest a potentially important role for AZA in the treatment of acquired MG in dogs. PMID:10493415

  1. Det var ikke min skyld : bruk av kognitiv behavioristiske metoder i arbeid med jenter som har vært utsatt for incest.

    OpenAIRE

    2003-01-01

    Oppgaven tar for seg jenter i grunnskolealder som har vært utsatt for incest, og bruken av kognitiv behavioristiske behandlingsmetoder. Jeg ønsket å se på mulighetene for å benytte denne behandlingsmetoden i arbeidet med incestofre for å dempe deres skyldfølelse og øke deres sosiale kompetanse. Problemstillingen er formulert som følger; ”I hvilken grad og på hvilken måte kan kognitiv behavioristiske behandlingsmetoder, med vekt på selvinstruksjoner, benyttes i behandling av jenter i ...

  2. Virtuelt skrivebord med open office

    DEFF Research Database (Denmark)

    Nielsen, Kurt Gammelgaard

    2009-01-01

    SDUs erfaringer med projektet Port 22: en virtuel platform med Open Office som kontorpakke til studerende.......SDUs erfaringer med projektet Port 22: en virtuel platform med Open Office som kontorpakke til studerende....

  3. Low-dose allopurinol plus azathioprine/cyclosporin/prednisolone, a novel immunosuppressive regimen.

    Science.gov (United States)

    Chocair, P; Duley, J; Simmonds, H A; Cameron, J S; Ianhez, L; Arap, S; Sabbaga, E

    1993-07-10

    Early rejection can still complicate renal transplantation even with cyclosporin. We added low-dose allopurinol (25 mg on alternative days) to "triple" immunosuppression with cyclosporin, prednisolone, and azathioprine for twelve recipients of cadaver renal grafts. The controls were fifteen patients on triple therapy alone. Only one rejection episode occurred among the allopurinol-treated patients, whereas eleven controls had rejections (seven with more than one episode). Allopurinol may be toxic when combined with azathioprine, yet the bone marrow tolerated the new regimen well. As expected, reduction of the azathioprine dose was necessary in the treated group. PMID:8100914

  4. Azathioprine as a corticosteroid-sparing agent in air-borne contact dermatitis

    Directory of Open Access Journals (Sweden)

    Verma Kaushal

    1996-01-01

    Full Text Available Two patients having air-borne contact dermatitis (ABCD caused by Parthenium hysterophorus.for 10 and 15 years respectively and without having had complete remissions in spite of oral betamethasone in a dose of 2-3 mg per day, experienced complete relief while taking 50-100 mg azathioprine for 5 and 12 weeks without having to take systemic corticosteroids. There were no side effects of azathioprine. With further experience and standardization of the treatment schedule, it may be possible to use azathioprine as a corticosteroid-sparing agent to reduce the side effects of corticosteroids in patients having ABCD.

  5. Nostalgitrip med Pikachu

    DEFF Research Database (Denmark)

    Konzack, Lars

    2016-01-01

    Sommeren 2016 vil blive husket for den omsiggribende dille, Pokémon Go, med over 100 millioner downloads. Tusindvis af især børn og unge, men også forældre med barnevogne og hele familier, kunne pludselig ses på gader og stræder, i parker og grønne områder med en smartphone i hånden på jagt efter...

  6. Processeringsoptimering med Canons software

    DEFF Research Database (Denmark)

    Precht, Helle

    2009-01-01

    . Muligheder i software optimering blev studeret i relation til optimal billedkvalitet og kontrol optagelser, for at undersøge om det var muligt at acceptere diagnostisk billedkvalitet og derved tage afsæt i ALARA. Metode og materialer Et kvantitativt eksperimentelt studie baseret på forsøg med teknisk og...... humant fantom. CD Rad fantom anvendes som teknisk fantom, hvor billederne blev analyseret med CD Rad software, og resultatet var en objektiv IQF værdi. Det humane fantom var et lamme pelvis med femur, der via NRPB’ er sammenlignelig med absorptionen ved et femårigt barn. De humane forsøgsbilleder blev...

  7. Utvärdering av logopedisk röstbehandling i Västerbottens läns landsting : Patienters självskattade röstbesvär före och efter behandling

    OpenAIRE

    Englund, Linn; Gunnarsson, Kristin

    2013-01-01

    Bakgrund Kraven på evidensbaserad vård ökar ständigt. Att jämföra patienters självskattade besvär före och efter behandling är ett sätt att utvärdera behandlingseffekten.  Rösthandikappindex (RHI) och VA-skala för röstbesvär är två verktyg för utvärdering av röstbehandling. Tidigare studier har visat att röstbehandling ger minskade självskattade röstbesvär. Syfte Syftet med denna studie var att med självskattningsformulär utvärdera effekten av logopedisk röstbehandling i Västerbottens läns la...

  8. Azathioprine and mercaptopurine in the management of patients with chronic, active microscopic colitis

    DEFF Research Database (Denmark)

    Münch, A; Fernandez-Banares, F; Munck, L K

    2013-01-01

    BACKGROUND: Microscopic colitis (MC) is a common chronic diarrhoeal disease, and remission can be induced with budesonide. However, diarrhoea relapses frequently when budesonide is tapered and a few patients become budesonide intolerant. AIM: To examine retrospectively the effect of azathioprine...

  9. Hyperbilirubinemi hos nyfødte – et kontroversielt tema. Erfaringer med nye indikasjoner for fototerapi og utskiftningstransfusjon

    OpenAIRE

    Alf Meberg

    2009-01-01

     SAMMENDRAGNye indikasjoner for behandling av hyperbilirubinemi hos nyfødte (bilirubinskjema fra Hillingdon sykehus,England) ble innført ved Vestfold sentralsykehus primo 1994. Endringene i panoramaet av behandlingstiltak(lysbehandling, utskiftningstransfusjon) ble registrert i kohortene av levende fødte ved sykehuset i toårsperioden1994-95 og sammenlignet med foregående treårsperiode 1991-93. Total lysbehandlingsprevalens falt signifikantfra 6,9% av levende fødte i perioden 1991-93 til 5,5% ...

  10. Haemolytic anaemia complicating the concurrent use of allopurinol & azathioprine after kidney transplantation

    OpenAIRE

    Neeraj Dhaun; Catherine Hanna; Maria Squires; Simon Watson

    2013-01-01

    Gout is a common problem in renal transplant recipients but often difficult to treat. Allopurinol can be combined with azathioprine but clinicians should be aware of the need for dose reduction, the potential to measure azathioprine breakdown products and the possible side effects of this combination. Leucopenia is a known side effect but this case report shows that haemolytic anaemia can also occur. [Int J Basic Clin Pharmacol 2013; 2(3.000): 330-332

  11. Haemolytic anaemia complicating the concurrent use of allopurinol & azathioprine after kidney transplantation

    Directory of Open Access Journals (Sweden)

    Neeraj Dhaun

    2013-06-01

    Full Text Available Gout is a common problem in renal transplant recipients but often difficult to treat. Allopurinol can be combined with azathioprine but clinicians should be aware of the need for dose reduction, the potential to measure azathioprine breakdown products and the possible side effects of this combination. Leucopenia is a known side effect but this case report shows that haemolytic anaemia can also occur. [Int J Basic Clin Pharmacol 2013; 2(3.000: 330-332

  12. Alopecia totalis in a patient with Crohn's disease and its treatment with azathioprine.

    OpenAIRE

    Goddard, C. J.; August, P. J.; Whorwell, P J

    1989-01-01

    A patient with Crohn's disease and alopecia totalis is described. Despite relative inactivity of the Crohn's disease, treatment with azathioprine was commenced. This led to complete regrowth of hair which was lost when the drug was discontinued. Re-institution of azathioprine restored hair to normal again and the patient has since declined to try stopping the drug despite the knowledge of potential side effects.

  13. Long-term azathioprine in rheumatoid arthritis: a double-blind study.

    OpenAIRE

    M. Silva; Hazleman, B L

    1981-01-01

    Several studies have demonstrated the beneficial effect of azathioprine in rheumatoid arthritis. But fears have been expressed about the possible mutagenic and teratogenic effects of prolonged use. If the drug could be withdrawn once remission is achieved, and this remission be then maintained with other agents, the possible complications of long-term therapy might be avoided. A double-blind controlled study was carried out over 8 months in 32 patients receiving long-term azathioprine therap...

  14. Randomised trial of mycophenolate mofetil versus azathioprine for treatment of chronic active Crohn's disease

    OpenAIRE

    Neurath, M; Wanitschke, R; Peters, M.; Krummenauer, F; zum, B; Schlaak, J.

    1999-01-01

    BACKGROUND—Crohn's disease is a chronic inflammatory disease of the alimentary tract. Azathioprine is an effective agent in the management of chronic active Crohn's disease leading to long term remission of disease activity. Such treatment leads to limited efficacy or side effects in a small subset of patients. 
AIMS—To compare efficacy and side effects of treatment with azathioprine plus corticosteroids versus mycophenolate mofetil (MMF) plus corticosteroids in patients wit...

  15. The effects of prednisone and azathioprine on circulating immunoglobulin levels and lymphocyte subpopulations in normal dogs.

    OpenAIRE

    Rinkardt, N E; Kruth, S.A.; A Kaushik

    1999-01-01

    This study investigates serum immunoglobulin (SIg) levels and lymphocyte subpopulations in normal dogs in response to putative immunosuppressive doses of prednisone and/or azathioprine. The objectives were to quantify SIg levels and lymphocyte subpopulations, including Thy-1+, CD4+, CD8+ and B cells, in normal dogs both before and after the administration of prednisone and/or azathioprine at 2 mg/kg, PO, each. Eighteen beagles were divided into 3 groups of 6 dogs each. Blood samples for radia...

  16. Are Pancreatic Autoantibodies Associated with Azathioprine-Induced Pancreatitis in Crohns Disease?

    OpenAIRE

    Weersma, Rinse K; Manou R Batstra; Kleibeuker, Jan H; van Dullemen, Hendrik M.

    2008-01-01

    Context Azathioprine is frequently used in the treatment of Crohn’s disease. A severe side effect is acute pancreatitis, which is specific for Crohn’s disease. Autoantibodies against exocrine pancreas occur in about 30% of Crohn’s disease cases but not in other inflammatory diseases. Pancreatic autoantibody positive Crohn’s disease patients might have a low grade inflammation of the pancreas which may be aggravated by the introduction of azathioprine, resulting in clinically overt acute pancr...

  17. Determination of azathioprine in bulk and pharmaceutical dosage form by HPTLC

    OpenAIRE

    Jain, Pritam S.; Pradip Thakre; Chaudhari, Amar J.; Chavhan, Manish L.; Surana, Sanjay J.

    2012-01-01

    Introduction: An HPTLC method for analysis of Azathioprine in bulk and pharmaceutical formulation has been established and validated. Materials and Methods: The analyte was separated on aluminium plates precoated with silica gel 60 F254. The mobile phase was Ethyl acetate: Methanol: Triethylamine (4:1:0.5v/v). Quantification was done by densitometric scanning at 300nm. Results: Response was a linear function of Azathioprine concentration in the range of 200-1200 ng/band. The limit of detectio...

  18. The effects of prednisone and azathioprine on circulating immunoglobulin levels and lymphocyte subpopulations in normal dogs.

    Science.gov (United States)

    Rinkardt, N E; Kruth, S A; Kaushik, A

    1999-01-01

    This study investigates serum immunoglobulin (SIg) levels and lymphocyte subpopulations in normal dogs in response to putative immunosuppressive doses of prednisone and/or azathioprine. The objectives were to quantify SIg levels and lymphocyte subpopulations, including Thy-1+, CD4+, CD8+ and B cells, in normal dogs both before and after the administration of prednisone and/or azathioprine at 2 mg/kg, PO, each. Eighteen beagles were divided into 3 groups of 6 dogs each. Blood samples for radial immunodiffusion assay of IgG, IgM and IgA, complete blood count (CBC)and flow cytometry were collected prior to the administration of any drugs and again after 14 d of azathioprine, prednisone or azathioprine and prednisone. Peripheral blood mononuclear cells were isolated using density centrifugation and were incubated with monoclonal antibodies reacting with CD4+, CD8+, Thy-1+ and membrane immunoglobulin. Lymphocyte subsets were quantified using flow cytometry. Azathioprine-treated dogs had no significant changes in SIg levels or lymphocyte subpopulations. Prednisone-treated dogs had significant (P azathioprine-treated dogs had significant (P dogs also had a significant decrease in erythrocyte number and a significant increase in the monocyte count. These findings suggest that azathioprine and prednisone in combination or prednisone alone may be useful for the treatment of T cell-mediated diseases since decreased circulating T cell levels were demonstrated following treatment. The combination of drugs or azathioprine alone may not be appropriate for treatment of acute or autoantibody-mediated immune disease, because SIg levels were minimally affected by treatment. PMID:9918329

  19. Meningspause med forstyrrelser

    DEFF Research Database (Denmark)

    Dehs, Jørgen

    1986-01-01

    Jürgen Habermas: "Der philosophische Diskurs der Moderne" - Æstetikken som krisesymptom, opgør med den fornuftskritiske tradition.......Jürgen Habermas: "Der philosophische Diskurs der Moderne" - Æstetikken som krisesymptom, opgør med den fornuftskritiske tradition....

  20. På vej med sproget

    DEFF Research Database (Denmark)

    Pedersen, Michael Svendsen

    Med udgangspunkt i et konkret undervisningsforløb, "Forberedelse til SOSU", hvor kvinder med anden etnisk baggrund end dansk forberedes til at tage en SOSU-uddannelse gennem en kombination af praktik og sprogundervisning, undersøges forskellige læringsdimensioner - kognitiv sprogtilegnelse...

  1. Unge med en twist

    DEFF Research Database (Denmark)

    Sørensen, Bo Wagner; Madsen, Diana Højlund

    Rapporten er baseret på gruppeinterview med 33 unge med etnisk minoritetsbaggrund. De unge er blevet spurgt om uddannelses- og erhvervsønsker og berører en række emner som familie, ligestilling, diskrimination og integration....

  2. Förälder till barn/ungdom med ätstörning – upplevelser och erfarenheter : En litteraturstudie

    OpenAIRE

    Kramer, Helena

    2015-01-01

    SAMMANFATTNING Bakgrund: Vid behandling av ätstörningar hos barn och ungdomar konstateras att föräldrars delaktighet har en betydande roll. Sjuksköterskan kan möta föräldrar till barn och ungdomar med ätstörning inom olika vårdinstanser och vårdformer och för att kunna ge stöd och god omvårdnad med familjen i fokus, är det av intresse att belysa upplevelser och erfarenheter hos föräldrar, av att leva med och/eller vårda barn/ungdom med ätstörning. Syfte: Att beskriva föräldrars upplevelser o...

  3. Tautomerism and spectroscopic properties of the immunosuppressant azathioprine

    Science.gov (United States)

    Makhyoun, Mohamed A.; Massoud, Raghdaa A.; Soliman, Saied M.

    2013-10-01

    The molecular structure and the relative stabilities of the four possible tautomers of the immunosuppressant azathioprine (AZA) are calculated by DFT/B3LYP method using different basis sets. The results of the energy analysis and thermodynamic treatment of the obtained data are used to predict the relative stabilities of the AZA tautomers. The effect of solvents such as DMSO and water on the stability of the AZA tautomers was studied using the polarized continuum method (PCM) at the same level of theory. The calculation predicted that, the total energies of all tautomers are decreased indicating that all tautomers are more or less stabilized by the solvent effect. The vibrational spectra of AZA are calculated using the same level of theory and the results are compared with the experimentally measured FTIR spectra. Good correlation is obtained between the experimental and calculated vibrational frequencies (R2 = 0.997). The electronic spectra of AZA in gas phase and in methanol as solvent are calculated using the TD-DFT method. The calculations predicted bathochromic shift in all the spectral bands in presence of solvent compared to the gas phase. Also the NMR spectra of all tautomers are calculated and the results are correlated with the experimental NMR chemical shifts where the most stable tautomer gives the best correlation coefficient (R2 = 0.996).

  4. Role of Rosemary Leaves Extract as A Protective Agent Against Azathioprine-Induced Toxicity in Rats

    Directory of Open Access Journals (Sweden)

    Hala M T El-Mougy*, Gehan A Youssef

    2011-04-01

    Full Text Available Background: Rosemary is widely found along the coasts of the Mediterranean Sea. Its leaves or extract were found to have a high antioxidant and anti-inflammatory activity. It is also used as an antispasmodic, analgesic, anti-rheumatic and expectorant. These actions are mainly due to its content of essential oils. Azathioprine (AZA is an immunosuppressive drug. It is widely used in many diseases. A major drawback is the occurrence of side-effects, especially acute pancreatitis. Aim of the work: This work was done to study the effect of dietary supplement of rosemary leaves as a strategy for amelioration of the side-effects of azathioprine. Material and Methods: Thirty-two adult male albino rats were used in this study. They were equally divided into four groups. Group I: control group, group II: rosemary group, the animals were given a daily oral dose of rosemary leaves extract. Group III: azathioprine group, the animals were given a single dose of AZA intraperitoneally. Group IV: rosemary azathioprine group: the rats were given daily doses of rosemary leaves extract then azathioprine in the last day of the experiment as in the previous regimen. The experiment continued for ten days. Blood samples were taken from all groups and examined for tumour necrosis factor alpha, serum amylase enzyme, C-reactive protein and renal function tests (serum urea and creatinine. Results: Rosemary significantly decreased the levels of tumour necrosis factor alpha, serum amylase enzyme and serum urea and C-reactive protein in rosemary AZA group compared to AZA group . Conclusion: The aqueous rosemary leaves extract has the ability to ameliorate the biochemical pathways of the side-effects of azathioprine, so it is advisable to give it concomitantly to patients treated by azathioprine.

  5. Relationship between red blood cell thiopurine methyltransferase activity and myelotoxicity in dogs receiving azathioprine.

    Science.gov (United States)

    Rodriguez, Damon B; Mackin, Andrew; Easley, Roger; Boyle, Carolyn R; Hou, Weiying; Langston, Cory; Walsh, Amy M; Province, Michael A; McLeod, Howard L

    2004-01-01

    Thiopurine methyltransferase (TPMT) produces inactive metabolites of azathioprine and, in humans, has a variable amount of activity. Humans with low TPMT activity commonly develop myelotoxicity when receiving azathioprine. Our study sought to characterize the distribution of TPMT activity in a population of dogs and to determine whether the pretreatment knowledge of red blood cell (RBC) TPMT activity could predict myelotoxicity in dogs receiving azathioprine. RBC TPMT activity was measured in 299 healthy dogs, and 9 dogs that represented a wide range of enzyme activity received azathioprine at a standard therapeutic dose for 30 days. TPMT activity in healthy dogs was log normally distributed and varied over an approximately 7-fold range. Geometric mean, minimum, and maximum RBC TPMT activities were 37.1, 16.3, and 115 nmol per gram of hemoglobin (gHb) per hour, respectively. TPMT deficiency was not identified. Two populations of TPMT activity in dogs were detected by statistical modeling (commingling analysis). Dogs with intermediate TPMT activity (14-38 nmol/gHb/h) receiving azathioprine had significantly lower neutrophil counts during week 4 than during weeks 0-3, whereas those with high activity (>39 nmol/gHb/h) did not have a significant change in neutrophil count. An analysis of TPMT activity in 6 dogs with a history of azathioprine-associated myelotoxicity in a clinical setting revealed either intermediate or high TPMT enzyme activity in all dogs, suggesting that TPMT activity, as measured in RBCs, is not the sole cause of severe azathioprine-associated myelosuppression in dogs. PMID:15188821

  6. DailyMed Webservices

    Data.gov (United States)

    U.S. Department of Health & Human Services — The DailyMed RESTful API is a web service for accessing current SPL information. It is implemented using HTTP and can be thought of as a collection of resources,...

  7. PubMed

    Data.gov (United States)

    U.S. Department of Health & Human Services — PubMed comprises more than 26 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to...

  8. DailyMed

    Data.gov (United States)

    U.S. Department of Health & Human Services — DailyMed provides high quality information about marketed drugs. This information includes FDA labels (package inserts). This Web site provides health information...

  9. Leg med vision

    DEFF Research Database (Denmark)

    Munk, Mette; Bertelsen, Katrine

    2011-01-01

    Bogen henvender sig primært til det pædagogiske personale med målgruppen daginstitutioner. Bogen skal stimulere arbejdet med at gøre bevægelse til en integreret del af kulturen i daginstitutioner - at få det pædagogiske personale til - at sætte ord på og spørgsmålstegn ved deres pædagogiske bevæg...

  10. Myelosuppression associated with azathioprine-allopurinol interaction after heart and lung transplantation.

    Science.gov (United States)

    Cummins, D; Sekar, M; Halil, O; Banner, N

    1996-06-15

    It is widely recommended that, during concurrent therapy with allopurinol, the azathioprine dosage should be decreased by at least two thirds. We retrospectively studied compliance with this guideline in 24 patients who had commenced allopurinol at a median of 33 months (range, 2-145 months) after heart and/or lung transplantation. The median reduction in azathioprine dose at initiation of allopurinol was 73.3% but ranged from 0% to 90% (>67% in 14 patients). Within 3 months, 11 (46%) of the patients became leukopenic (white blood cell count azathioprine by two thirds or greater reduced but did not abolish the risk of myelotoxicity. These data highlight the need for close hematological monitoring of patients treated with this drug combination. Agents other than allopurinol should be considered for treating hyperuricemia after thoracic organ transplantation. PMID:8669118

  11. Samomorilnost med mladimi

    OpenAIRE

    Kranjc, Teja

    2010-01-01

    V diplomskem delu predstavljamo problematiko samomorilnosti med mladimi. Opisali smo samomorilnost skozi zgodovino, statistične podatke o samomoru v Sloveniji in v Celjski regiji. V Sloveniji predstavlja samomorilnost velik problem, saj imamo izredno visok samomorilni količnik, v primerjavi z drugimi državami sveta, prisoten že več desetletij. Še zlasti pa je velika samomorilna problematika med mladimi, kjer statistični podatki beležijo porast samomorov v populaciji adolescentov. Z namenom, d...

  12. Azathioprine and 6-mercaptopurine (6-MP) suppress the human mixed lymphocyte reaction (MLR) by different mechanisms.

    OpenAIRE

    Al-Safi, S A; Maddocks, J L

    1984-01-01

    6-MP inhibitory effects on the MLR were reversed by AIC (46%), adenine (32%), hypoxanthine (89%), adenosine (86%) and inosine (93%). AIC, adenine, hypoxanthine and inosine had no effect on azathioprine inhibition of the MLR. Adenosine at 10 microM caused 29% reversal and had no effect at 100-400 microM on azathioprine inhibition of the MLR. Reversal of 6-MP suppression of the MLR was decreased with the delay of adenosine addition. Guanine, xanthine and guanosine caused no reversal of 6-MP or ...

  13. The effect of azathioprine on anastomotic healing: an experimental study in rats

    DEFF Research Database (Denmark)

    Stolzenburg, Tilo; Ljungmann, Ken; Christensen, Henrik

    2007-01-01

    healing was tested. METHODS: In an experimental study, rats were randomly given one oral dose of azathioprine (5 mg or 20 mg/kg body weight per day) or placebo. After 28 days of treatment, a left colonic anastomosis was performed. After three days of healing, the breaking strengths of the anastomoses were...... tested, along with measurements of azathioprine major metabolite concentrations: 6-thioguanine and 6-methyl-mercaptopurine. RESULTS: There were no significant differences in the anastomotic breaking strength between the three groups. CONCLUSIONS: Daily treatment for four weeks with high or low...

  14. Mycophenolate mofetil versus azathioprine for maintenance treatment of lupus nephritis.

    Science.gov (United States)

    Kaballo, Babikir G; Ahmed, Ahmed Elias; Nur, Musa Mohammed; Khalid, Ismail Osman; Abu-Aisha, Hasan

    2016-01-01

    To compare the efficacy of mycophenolate mofetil (MMF) with that of azathioprine (AZA) drugs in the maintenance therapy of lupus nephritis (LN) patients, we studied 81 Sudanese patients with LN (32 in Class III, 34 in Class IV, and 15 in combined Class V + IV of the ISN/RPS 2003 Classification). All patients received induction therapy consisting of monthly intravenous pulse doses of cyclophosphamide (CYC) (500 mg/m 2 of body-surface area) for six months, plus three consecutive pulses of intravenous methylprednisolone 15 mg/kg/day of body weight (maximum 500 mg). Subsequently, 41 (50.6%) patients were randomized into a group that received oral MMF (22 mg/kg/day), and 40 (49.4%) patients randomized to a group that received oral AZA (2 mg/kg/day). All patients initially received oral prednisone (1 mg/kg of body weight daily) for four weeks. The baseline characteristics of the two groups were similar. Total remission rate was 75.3% (80.5% in MMF and 70% in AZA), complete remission rate of 54.3% (56.1% with MMF and 52.5% with AZA), and a partial remission rate of 21% (24.4% with MMF and 17.5% with AZA) over 29 months. During maintenance therapy, six patients died (four in the AZA group and two in the MMF group), and end-stage renal disease (ESRD) developed in five patients (three in the AZA group and two in the MMF group). During the 36-months of the study, both groups had comparable event-free survival rate for the composite end point of death or ESRD and rate of relapse-free survival. Furthermore, both groups had no significant differences in terms of frequency of hospitalization, amenorrhea, infection, nausea, and vomiting. We conclude that our study showed that short-term therapy with intravenous CYC followed by maintenance therapy with oral MMF or AZA had similar efficacy and safety for the treatment of patients with moderate to severe LN. PMID:27424688

  15. Grensen mellom legitime markedsstrategier og markedsmanipulasjon ved HFT-handel: Om HFT-handel, ved bruk av enkelte markedsstrategier, kan være i strid med forbudet mot markedsmanipulasjon, og en komparativ fremstilling av nåværende og fremtidige plikter knyttet til bruken av HFT-handel.

    OpenAIRE

    Solbakken, Tone Jørgensen

    2015-01-01

    Oppgaven behandler og besvarer to problemstillinger. Den første problemstillingen er om man ved bruk av HFT som handelsmetode i visse typetilfeller kan rammes av forbudet mot markedsmanipulasjon i vphl. §3-8. Videre vil gjeldende informasjonsplikter som er nært knyttet til forbudet mot markedsmanipulasjon bli behandlet og sammelignet med nye reguleringsinitiativ for verdipapirmarkedene som er ment å regulere og adressere utfordringene ved HFT-handel. Den andre problemstillingen er om det økte...

  16. Professionalisme med innovativt potentiale

    DEFF Research Database (Denmark)

    Nielsen, Inger Marie

    To teoretiske sværvægtere bliver koblet sammen i Inger Marie Larsen-Nielsen arbejdspapir om professionalisme med innovativt potentiale. De to teoretikere er læringsteoretikeren John Dewey og socialpsykologen Georg Herbert Mead, som er sat sammen i en teoretisk forståelsesramme omkring professionel...

  17. Paclitaxels farmakogenomik hos patienter med kræft i æggestokken

    DEFF Research Database (Denmark)

    Bergmann, Troels Korshøj; Mirza, Mansoor Raza; Andersen, Charlotte Brasch;

    Formål og baggrund: Paclitaxel (Taxol®) er et kemoterapeutikum der bruges til behandling af bl.a æggestokkræft. Paclitaxel doseres individuelt (175mg/m2) men alligevel er der klinisk betydende variation i forekomsten af bivirkninger (neurotoksicitet, kvalme/opkast, knoglemarvspåvirkning m.......fl). Vores hypotese er at en betydelig del af variationen skyldes genetiske forskelle mellem patienterne. Den hyppigste kilde til genetisk variation er single nukleotide polymorphisms ie SNPs. Vi vil undersøge om SNPs i gener der koder for proteiner der har betydning for transport og omsætning af paclitaxel...... mellem patienterne og fungerer således som dobbeltblindede randomiserede expositioner. Data indsamles prospektivt ved at rekruttere patienter med æggestokkræft der skal have paclitaxel og carboplatin i Odense, Vejle, Herlev, Herning, Lund eller Linköping. Der tages blod fra til genanalyse og plasma til...

  18. Behandling af våd aldersrelateret makuladegeneration med vaskulaer endotel vaekstfaktorhaemmer. Gennemgang af et Cochrane-review

    DEFF Research Database (Denmark)

    Bloch, Sara Brandi; Larsen, Michael

    2009-01-01

    This evaluation of a Cochrane-review including five clinical trials of good methodological quality indicates that the antiangiogenic therapeutic agents, pegaptanib and ranibizumab, are effective treatment strategies for neovascular Age-Related Macular Degeneration (AMD). The review does not inclu...

  19. Mentaliseringsbaserad behandling av patienter med borderline personlighetsstörning : Infallsvinklar från patientgrupp och behandlare

    OpenAIRE

    Söderman, Lotta

    2008-01-01

    The aim of this paper was to illuminate the effect of mentalizationbased psychotherapy. The patients in the survey group were interviewed before and after treatment with regard to specific symptoms of borderline personality disorder and symptoms of other personality disorders with the semi structured interviews ZAN-BPD and SCID-II. Open interview questions that were worked up in a qualitative manner were as well put to the patients that had received the treatment program. A focus group interv...

  20. Behandling af renovaskulær hypertension med transluminal angioplastik--13 års erfaring--sekundærpublikation

    DEFF Research Database (Denmark)

    Øvrehus, Kristian Altern; Andersen, Poul Erik; Jacobsen, Ib Abildgaard

    2008-01-01

    angioplasty. A total of 124 patients were treated; 31% were normotensive immediately after angioplasty, 59% had improved blood pressure control and 10% had unchanged hypertension. The corresponding figures after six months and at the latest follow-up were 13, 72 and 15%. Udgivelsesdato: 2008-Jan-21...

  1. Behandling af reumatoid artrit med anti-tumornekrosefaktor-alpha-antistof. Individuel monitorering af biotilgaengelighed og immunogenicitet-- sekundaerpublikation

    DEFF Research Database (Denmark)

    Bendtzen, Klaus; Geborek, Pierre; Svenson, Morten;

    2007-01-01

    Remicade/infliximab is effective in rheumatoid arthritis (RA), but response failure is frequent. Sera from 106 RA patients were monitored using an RIA for functional infliximab and an RIA for anti-infliximab antibody (Ab). S-infliximab varied considerably, e.g. 0-22 microg/ml before the 3rd infus...

  2. Skandinaviske kliniske retningslinjer for præhospital behandling af patienter med svære hovedtraumer

    DEFF Research Database (Denmark)

    Juul, Niels; Sollid, Snorre; Sundstrøm, Terje;

    2008-01-01

    Head trauma causes the death of many young persons. The number of fatalities can be reduced through systematic management. Preventing secondary brain injury together with the fastest possible transport to a neurosurgical unit has been shown to be effective in reducing mortality and morbidity. Evi...

  3. Uppföljning av logopedisk behandling för patienter med träningsinducerad vocal cord dysfunction

    OpenAIRE

    Hamberg, Lena; Karlsson, Sanna

    2014-01-01

    Abstract. Several treatment options are described for patients with vocal cord dysfunction. At Karolinska University hospital, these patients are offered treatment by speech and language pathologists. The current study describes traits and treatment effects for 148 people diagnosed with exercise-induced vocal cord dysfunction at Karolinska University hospital who received treatment by speech and language pathologists in 2005-2012. Data were collected from medical records and through a questi...

  4. Behandling med duodenal-jejunal bypass-sleeve ved svær overvægt

    DEFF Research Database (Denmark)

    Rohde, Ulrich; Gylvin, Silas; Vilmann, Peter;

    2014-01-01

    Overweight and obesity are risk factors for several co-morbidities reducing life expectancy. Conservative treatment of obesity is generally ineffective in the long-term. Bariatric surgery has proven effective, but is associated with potential complications. Duodenal-jejunal bypass sleeve is a novel...

  5. Intrauterin insemination med donorsaed. Behandling af ufrivillig barnløshed på grund af mandlig infertilitet

    DEFF Research Database (Denmark)

    Vilsbøll, Tina; Helmsøe-Zinck, Lise; Andersen, A N

    1994-01-01

    Intrauterine insemination with cryopreserved donor semen was performed in 114 women in a total of menstrual 381 cycles during the period 1.2.1991 to 15.5.1993. Eighty-one pregnancies were recorded corresponding to a conception rate of 21% per insemination cycle. After ten cycles the probability of...... conception and expected delivery was respectively 96% and 86%. The results show that intrauterine insemination with donor semen is a good treatment for couples with male infertility. Ultrasonic measurement of the follicles and timing of hCG injection were used for optimal timing of intrauterine donor...... insemination. The quality of the semen used for insemination is important. It is recommended to inseminate with at least two million of spermatozoa where at least 20% have normal motility....

  6. Mentaliseringsbasert psykoterapi - En mulig tilnærming til behandling av pasienter med unnvikende og paranoide personlighetsforstyrrelser?

    OpenAIRE

    Mannsåker, Ingeborg; Sørensen, Kristine Bjørkaas; Zamfirova, Biliana

    2011-01-01

    The present thesis explores whether mentalization-based psychotherapy (MBT), on theoretical grounds, may be applicable in the treatment of patients with avoidant and paranoid personality disorders. We describe the development of mentalization and the principles of MBT. Characteristics of the two diagnostic groups in question are presented and compared with borderline personality disorder, for which the effectiveness of MBT has been empirically documented. We discuss whether pat...

  7. A Rare Case of Azathioprine-Induced Sweet's Syndrome in a Patient with Crohn's Disease.

    Science.gov (United States)

    Ben Salem, Chaker; Salem, Chaker B; Larif, Sofiene; Fathallah, Neila; Slim, Raoudha; Aounallah, Amina; Sakhri, Jaballah; Hmouda, Houssem

    2015-01-01

    Sweet's syndrome has been reported in association with inflammatory diseases such as Crohn's disease. It has also been reported in association with several drugs. Here, we report a rare case of Sweet's syndrome induced by azathioprine in a patient with Crohn's disease. PMID:26219289

  8. Comparative study of azathioprine-interferon g dispensing to patients with idiopathic pulmonary fibrosis

    Directory of Open Access Journals (Sweden)

    Fotios Drakopanagiotakis

    2009-01-01

    Full Text Available SUMMARY. Introduction: Idiopathic pulmonary fibrosis (IPF is characterized by progressive deterioration of lung function, leading ultimately to death. No pharmacological treatment has been found to stabilize the evolution of the disease, but interferon-g and azathioprine have been used as therapeutic options. Aim: To compare the effectiveness of treatment with interferon-g plus low dose prednisone or azathioprine plus low dose prednisone in patients with IPF. Materials and methods: Patients newly diagnosed with IPF were recruited, 22 in total, of whom 10 received azathioprine plus prednisone and 12 patients received interferon-g plus prednisone for six months. Clinical evaluation, lung function tests, HRCT, bronchoscopy and bronchoalveolar lavage (BAL were performed at baseline and after six months of treatment. Results: All patients were alive after six months of treatment. No statistically significant difference between the two groups was detected regarding clinical deterioration, inflammatory biomarkers such as erythrocyte sedimentation rate (ESR, C-reactive protein (CRP, and BAL cell sub-populations. There was a trend, not statistically significant, towards a greater reduction in forced vital capacity and diffusing capacity for carbon monoxide in the interferon-g group. Conclusion: Interferon-g does not offer any therapeutic advantage over azathioprine as regards the clinical course, lung function tests and BAL cell counts of patients with IPF. Pneumon 2009, 22(3:240-253.

  9. Use of azathioprine for non-thymoma myasthenia and risk of cancer

    DEFF Research Database (Denmark)

    Pedersen, E G; Pottegård, Anton; Hallas, J; Friis, S; Hansen, K; Jensen, P E H; Gaist, D

    2013-01-01

    BACKGROUND AND PURPOSE: To evaluate the association between the use of azathioprine and risk of cancer in patients with non-thymoma myasthenia gravis (MG) in a nationwide setting. METHODS: Case-control study based on population-based registries. Cases were patients with MG with a first time...

  10. Effect of levamisole and azathioprine on the human mixed lymphocyte reaction (MLR).

    OpenAIRE

    Al-Safi, S A; Maddocks, J L

    1984-01-01

    Levamisole (1.25-4.15 microM) had no effect on tritiated thymidine incorporation into DNA of mixed lymphocyte cultures. Moreover, it did not cause any reversal of azathioprine (18-36 microM) inhibitory effects on the MLR.

  11. Alcohol binging causes peliosis hepatis during azathioprine therapy in Crohn's disease

    Institute of Scientific and Technical Information of China (English)

    Christoph Elsing; Joerg Placke; Thomas Herrmann

    2007-01-01

    Patients with inflammatory bowel disease have normal life expectancy and, due to modern immunosuppressive therapies, also a normal quality of life. Since mostly young people are affected, their social behaviour suits this environment. Alcohol binging is an increasingly disturbing factor among young people. We describe a patient with Crohn's disease, treated with azathioprine,who developed peliosis hepatis after three epsiodes of alcohol binging. Liver toxicity was not observed previously during the course of the treatment.Azathioprine-induced peliosis hepatis is thought to be idiosyncratic in humans. From animal studies, however,it is clear that hepatic depletion of glutathione leads to azathioprine toxicity to the sinusoidal endothelial cells. Damage of these cells causes peliosis hepatis.Since alcohol binging leads to hepatic glutathione depletion, we conclude that in our patient the episodes of binging have reduced liver gluathione content and therefore this has increased azathioprine toxicity causing peliosis hepatis. The problem of alcohol binging has not yet been addressed in IBD patients undertaking immunosuppressive therapy. This should be reviewed in future considerations regarding patients advice.

  12. Responsiv webbutveckling med Joomla

    OpenAIRE

    Strandén, Pyry

    2013-01-01

    Responsiv design är ett begrepp som Ethan Marcotte gjorde känd i sin artikel ”Re-sponsive Web Design” i webbtidningen ”A list apart” år 2010. I dagens läge vet en webbutvecklare sällan i förhand med hurdan apparat människorna besöker sina publikationer med. Det kan vara en smarttelefon, surfplatta, bordsdator eller t.o.m. en televis-ion. Alla dessa apparater kan ha olika skärmstorlekar och funktioner och ställer då också krav på hur en webbutvecklare planerar sin webbplats. Att planera en web...

  13. Farlig sex med engle

    DEFF Research Database (Denmark)

    Mejrup, Kristian

    2013-01-01

    De fleste af os tænker ikke på engle som kønnede væsner med en seksualitet, og selv om vi er i stand til at acceptere engle i alle mulige afskygninger, fra juletræets tyksakker i glitrende guld til frygtindgydende skikkelser i de bibelske skrifter, så er vi tilbøjelig til at ignorere spørgsmålet ...

  14. Statistisk analyse med SPSS

    OpenAIRE

    Linnerud, Kristin; Oklevik, Ove; Slettvold, Harald

    2004-01-01

    Dette notatet har sitt utspring i forelesninger og undervisning for 3.års studenter i økonomi og administrasjon ved høgskolen i Sogn og Fjordane. Notatet er særlig lagt opp mot undervisningen i SPSS i de to kursene ”OR 685 Marknadsanalyse og merkevarestrategi” og ”BD 616 Økonomistyring og analyse med programvare”.

  15. Tiden med Elias

    DEFF Research Database (Denmark)

    Nagbøl, Søren

    - og studentereksamen - chancen til at gennemføre drømmen om at kunne beskæftige sig med de temaer, han formulerede som meningsfulde. Det er også en fortælling om at tidsånden, sådan som den organiseres i undervisningssystemerne nu om dage, ikke er en naturlov. At "Bildung" kan foregå på helt andre...

  16. Water desalination with MED

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez, Daniel; Caerols, Pablo; Olmedo, Juan Carlos [Enorchile (Chile)

    2010-07-01

    The greenhouse gas emissions from the Chilean copper mining industry account for 61% of total and this has been a serious cause for concern. The amount of water used for mining operations is also great and it has to be desalinated. The carbon footprint of desalinated water is large. This paper discusses the desalination of water using multi-effect desalination (MED). The most commonly used technology for desalination is the reverse osmosis process, where pre-treated water is forced through a semi-permeable membrane. The MED technology uses low-pressure steam from turbine or engine exhaust gases, which makes it highly efficient and cost effective. The process is briefly explained and a diagram shows the flow process. Advantages include low electricity consumption, low maintenance, and high reliability. Additionally, no pretreatment of the water is required and the process thus also decreases the carbon footprint. It can be concluded that MED combined with a power plant is a powerful solution for mine operations.

  17. MedPAC Data Book

    Data.gov (United States)

    U.S. Department of Health & Human Services — MedPACs Data Book is the result of discussions with congressional staff members regarding ways that MedPAC can better support them. Some of the information it...

  18. Matrixregning med SAS

    DEFF Research Database (Denmark)

    Andersen, Aage T.; Feilberg, Michael; Milhøj, Anders

    IML i SAS anvendes til matrixberegninger som en integreret del af SAS pakken. Den anvendes typisk til matrixberegninger i tilknytning til andre SAS applikationer, fx kan matricer let dannes ud fra datasæt i SAS. Desuden indeholder IML en række videregående matematiske og statistiske subroutiner......, der ikke findes andre steder i SAS.I bogen gennemgås matrixregning svarende til et indledende matematikkursus ved en højere læreanstalt. Den teoretiske gennemgang understøttes og demonstreres konsekvent med IML programmering, så fokus er på praktiske anvendelser af matricer....

  19. Long-term follow-up of cyclophosphamide compared with azathioprine for initial maintenance therapy in ANCA-associated vasculitis

    DEFF Research Database (Denmark)

    Walsh, M.; Faurschou, M.; Berden, A.;

    2014-01-01

    BACKGROUND AND OBJECTIVES: Treatment with azathioprine within 3 months of remission induction with cyclophosphamide is a common treatment strategy for patients with ANCA-associated vasculitis. This study comprised patients undergoing long-term follow-up who were randomly allocated to azathioprine...... after 3-6 months or after 12 months of cyclophosphamide treatment. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Patients from 39 European centers between 1995 and 1997 with a new diagnosis of ANCA-associated vasculitis that involved the kidneys or another vital organ were eligible. At the time of...... diagnosis, participants were randomly allocated to convert to azathioprine after 3-6 months (the azathioprine group) or after 12 months of cyclophosphamide (the cyclophosphamide group). Patients who did not achieve a remission within 6 months were excluded. This study assessed relapses, ESRD, and death...

  20. "Ett mönster som är svårt att förändra" : En kvalitativ studie om professionellas arbete med och syn på män som utövar våld i nära relationer

    OpenAIRE

    Hallborg, Stefanie; Ehrling, Isabell

    2016-01-01

    Studiens syfte var att undersöka kopplingen mellan hur professionella inom socialt arbete arbetar med män som utövat våld i en nära relation och hur de ser på problemet. Som metod användes en kvalitativ intervjustudie med sju yrkesverksamma inom socialt arbete. De informanter som deltog arbetade antingen inom socialtjänsten eller i verksamheter som erbjuder behandling för våldsutövande män. I studien användes ett genusperspektiv och den ekologiska modellen som teoretiska utgångspunkter. Studi...

  1. Le cas clinique du mois. Sclérose hepato-portale chez un patient traité par azathioprine

    OpenAIRE

    Roland, S.; Delwaide, Jean; Cornet, G.; Mahieu, Ph; Jacquet, N.; Belaiche, Jacques

    1998-01-01

    We report a case of hepatoportal sclerosis in a renal transplant patient treated with azathioprine. The initial symptom was ascites. On the biochemical level, there were cholestasis without cytolysis or hepatocellular insufficiency. A presinusoidal portal hypertension was found on haemodynamic studies, without portal thrombosis at CT-scan. A diagnosis of hepatoportal sclerosis was evoked on histology and attributed to azathioprine. This case gives an illustration of a classical albeit rare co...

  2. Lymphoproliferative cancer and other malignancy in patients with rheumatoid arthritis treated with azathioprine: a 20 year follow up study.

    OpenAIRE

    Silman, A.J.; Petrie, J.; Hazleman, B; Evans, S. J.

    1988-01-01

    Two hundred and two patients with rheumatoid arthritis (RA) starting treatment with large doses of azathioprine (median 300 mg/day) between 1964 and 1974 were followed up until March 1984. All but one patient (99.5%) were traced from either hospital or general practice records; and death certificates, where relevant, were obtained. A comparison group of 202 patients with RA not treated with azathioprine was selected from the diagnostic index of another rheumatology unit and followed up in 198...

  3. [Bone marrow depression after azathioprine. New discoveries on an old drug].

    Science.gov (United States)

    Löwhagen, G B; Lindstedt, G

    2000-02-01

    Azathioprine, a cytostatic and immunosuppressive drug in use for some 30 years, can give rise to life-threatening neutropenia and thrombocytopenia. This may be caused by unexpectedly high concentrations of cytotoxic metabolites due to abnormally slow inactivation of 6-mercaptopurine (6-MP) by thiopurine S-methyltransferase (TPMT) and/or xanthine oxidase. Low TPMT activity may be due to genetic polymorphism or interaction with drugs such as salicylic acid derivatives, while xanthine oxidase may be inhibited by allopurinol. High TPMT activity, on the other hand, may hamper cytostatic treatment. Safer and more effective treatment with azathioprine and its metabolite 6-MP becomes possible with new laboratory methods for pharmacotherapy monitoring. PMID:10707497

  4. Role of Rosemary Leaves Extract as A Protective Agent Against Azathioprine-Induced Toxicity in Rats

    OpenAIRE

    Hala M T El-Mougy*, Gehan A Youssef

    2011-01-01

    Background: Rosemary is widely found along the coasts of the Mediterranean Sea. Its leaves or extract were found to have a high antioxidant and anti-inflammatory activity. It is also used as an antispasmodic, analgesic, anti-rheumatic and expectorant. These actions are mainly due to its content of essential oils. Azathioprine (AZA) is an immunosuppressive drug. It is widely used in many diseases. A major drawback is the occurrence of side-effects, especially acute pancreatitis. Aim of the wor...

  5. Corticosteroids and Azathioprine Do Not Prevent Radiation-Induced Lung Injury

    OpenAIRE

    Eva Kwok; Chan, Charles K.

    1998-01-01

    The case of a man who presented with dyspnea and a dry cough six weeks after mediastinal radiotherapy for malignant thymoma is described. The patient was on prednisone (30 mg/day) and azathioprine (100 mg/day) throughout the course of radiation. The respiratory difficulties developed as the dose of prednisone was gradually decreased to 20 mg/day postradiation. Chest x-ray showed bilateral pulmonary infiltrates. Computed tomography scan of the thorax confirmed bilateral ground glass opacities,...

  6. Evaluation of Azathioprine-Induced Cytotoxicity in an In Vitro Rat Hepatocyte System

    OpenAIRE

    Abdullah Al Maruf; Luke Wan; O’Brien, Peter J

    2014-01-01

    Azathioprine (AZA) is widely used in clinical practice for preventing graft rejection in organ transplantations and various autoimmune and dermatological diseases with documented unpredictable hepatotoxicity. The potential molecular cytotoxic mechanisms of AZA towards isolated rat hepatocytes were investigated in this study using “Accelerated Cytotoxicity Mechanism Screening” techniques. The concentration of AZA required to cause 50% cytotoxicity in 2 hrs at 37°C was found to be 400 μM. A sig...

  7. Optimizing 6-mercaptopurine and azathioprine therapy in the management of inflammatory bowel disease

    OpenAIRE

    Bradford, Kara; Shih, David Q

    2011-01-01

    The thiopurine drugs, 6-mercaptopurine (6-MP) and azathioprine, are efficacious in the arsenal of inflammatory bowel disease (IBD) therapy. Previous reports indicate that 6-thioguanine nucleotide (6-TGN) levels correlate with therapeutic efficacy, whereas high 6-methylmercaptopurine (6-MMP) levels are associated with hepatotoxicity and myelotoxicity. Due to their complex metabolism, there is wide individual variation in patient response therein, both in achieving therapeutic drug levels as we...

  8. Pharmacogenetics of azathioprine in inflammatory bowel disease: A role for glutathione-S-transferase?

    OpenAIRE

    Stocco, Gabriele; Pelin, Marco; Franca, Raffaella; De Iudicibus, Sara; Cuzzoni, Eva; Favretto, Diego; Martelossi, Stefano; Ventura, Alessandro; Decorti, Giuliana

    2014-01-01

    Azathioprine is a purine antimetabolite drug commonly used to treat inflammatory bowel disease (IBD). In vivo it is active after reaction with reduced glutathione (GSH) and conversion to mercaptopurine. Although this reaction may occur spontaneously, the presence of isoforms M and A of the enzyme glutathione-S-transferase (GST) may increase its speed. Indeed, in pediatric patients with IBD, deletion of GST-M1, which determines reduced enzymatic activity, was recently associated with reduced s...

  9. Generation of radical anions from metronidazole, misonidazole and azathioprine by photoreduction in the presence of EDTA

    International Nuclear Information System (INIS)

    Ultraviolet irradiation of the nitroimidazole derivatives metronidazole, misonidazole, azathioprine and 1-methyl-4-nitroimidazole in aqueous solution with various reductants produced the respective nitro radical anions, as detected by electron spin resonance spectroscopy. The most effective reductant, yielding high concentrations of the radical anions, was EDTA at pH 10. NADH, NADPH, formaldehyde glutathione and methanol were also tested but were less efficient as reductants. (author)

  10. Generation of radical anions from metronidazole, misonidazole and azathioprine by photoreduction in the presence of EDTA

    Energy Technology Data Exchange (ETDEWEB)

    Moore, D.E.; Chignell, C.F.; Sik, R.H.; Motten, A.G.

    1986-11-01

    Ultraviolet irradiation of the nitroimidazole derivatives metronidazole, misonidazole, azathioprine and 1-methyl-4-nitroimidazole in aqueous solution with various reductants produced the respective nitro radical anions, as detected by electron spin resonance spectroscopy. The most effective reductant, yielding high concentrations of the radical anions, was EDTA at pH 10. NADH, NADPH, formaldehyde glutathione and methanol were also tested but were less efficient as reductants.

  11. Evaluation of azathioprine on lesion severity and lymphocyte blastogenesis in dogs with perianal fistulas.

    Science.gov (United States)

    Harkin, Kenneth R; Phillips, Dianne; Wilkerson, Melinda

    2007-01-01

    Fourteen dogs with perianal fistulas were entered into a prospective clinical study to investigate the effects of long-term azathioprine on clinical outcome and to determine if the clinical results correlated with lymphocyte blastogenesis tests. Complete remission of perianal fistulas was seen in eight (57%) of 14 dogs; partial remission occurred in one (7%) dog; and no response was detected in five (36%) dogs. The results of lymphocyte blastogenesis assays did not correlate with therapeutic response. PMID:17209081

  12. Mødet med Nanoscience

    DEFF Research Database (Denmark)

    Holmegaard, Henriette Tolstrup; Malm, Rie Hjørnegaard; Madsen, Lene Møller

    Formålet med undersøgelsen er at undersøge de studerendes møde med studiet, deres integration på studiet og de studerendes overvejelser om at blive eller forlade studiet. Undersøgelsen formidler de studerendes perspektiv på første studieår på nanoscience og bidrager med input, der kan bruges...

  13. Gruppemusikterapi med patienter med borderline-personlighedsforstyrrelse i dagbehandlingsregi

    DEFF Research Database (Denmark)

    Hannibal, Niels

    2008-01-01

    Denne artikel er første redegørelse for de erfaringer, som er gjort med gruppemusikterapi (GMT) for patienter med borderline-personlighedsforstyrrelse (BPF) i dagbehandlingsregi på Aalborg Psykiatriske Sygehus. Artiklen indeholder både konkrete anvisninger til aktiviteter og interventioner, ligesom...

  14. Instrumentell röstregistrering : En jämförande studie med talfonetogram och VoxLog

    OpenAIRE

    Jansson, Marie; Sund, Linda

    2014-01-01

    Bakgrund Röstproduktionen är föränderlig och påverkas av miljö och situation. Ofördelaktigt röstbeteende kan leda till röststörningar. Vid behandling av röststörningar är det essentiellt att kartlägga ogynnsamma röstbeteenden. Ljudstudioinspelningar har visat sig otillräckliga vid sådana kartläggningar. Ett verktyg med potential att möjliggöra en mer representativ bild av röstanvändandet är röstackumulatorn VoxLog. Syfte Syftet var att utifrån röstparametrarna SPL och F0 jämföra registreringa...

  15. En sjukdom i kropp och själ - Anorexia nervosa och behovet av avancerad omvårdnad : En intervjustudie med sjuksköterskor inom somatisk vård

    OpenAIRE

    Hall, Ida; Midestad, Erica

    2016-01-01

    Introduktion: Sjuksköterskor inom somatisk vård möter och vårdar vid ett antal tillfällen per år patienter med diagnosen anorexia nervosa. Anorexia nervosa är en allvarlig sjukdom med hög dödlighet. Diagnosen påverkar både patientens somatiska och psykiatriska status. Patienter med diagnosen anorexia nervosa beskriver ett omvårdnadsbehov ur både ett somatiskt- och psykiatriskt omvårdnadsperspektiv. En framgångsrik allians är viktig för att vård och behandling ska kunna uppnås och upprätthålla...

  16. Høreapparat med identifikationsenhed

    DEFF Research Database (Denmark)

    2006-01-01

    Denne frembringelse vedrører et høreapparat, der omfatter en identifikationsenhed med en antenne tilpasset til at modtage et aktiveringssignal og til at sende et svarsignal samt med en signalgenerator tilpasset til at genere svarsignalet når aktiveret af aktiveringssignalet, og ligeledes vedrører...

  17. Sweet syndrome on a patient with autoimmune hepatitis on azathioprine and CMV infection.

    Science.gov (United States)

    Xenophontos, Eleni; Ioannou, Antreas; Constantinides, Thrasos; Papanicolaou, Eleni

    2016-02-01

    Sweet syndrome (SS) is a rare inflammatory process presenting with painful erythematous skin eruptions, accompanied by fever and neutrophilia. It is associated with upper respiratory infection in fertile women (classic form), malignancy, infections, drugs and autoimmune diseases. Its pathogenesis remains to be determined. Nevertheless, cytokines may have a prominent role, due to a rapid response after corticosteroid administration. We describe a 32-year-old female with autoimmune hepatitis on azathioprine and prednisone, presenting with fever and inflammatory skin eruptions. Histologic examination of the skin lesions showed neutrophilic infiltrations of the dermis, confirming the diagnosis of SS. Concurrently, she tested borderline positive for recent CMV infection. PMID:26913201

  18. Erythema nodosum as azathioprine hypersensitivity reaction in a patient with bullous pemphigoid

    Directory of Open Access Journals (Sweden)

    Jose Antonio Vargas-Hitos

    2013-01-01

    Full Text Available A 65-year-old woman with bullous pemphigoid presented with fever and several red-purple nodular subcutaneous lesions on both lower legs 1 week after starting treatment with azathioprine (AZA. Biopsy of a skin nodule was compatible with erythema nodosum (EN and hypersensitivity reaction to AZA was suspected. AZA was subsequently discontinued, observing complete remission of fever and EN within 2 weeks. This case highlights the importance of recognizing EN as a possible manifestation of hypersensitivity reaction to AZA.

  19. Azathioprine in giant cell arteritis/polymyalgia rheumatica: a double-blind study.

    OpenAIRE

    M. Silva; Hazleman, B L

    1986-01-01

    The ability of azathioprine to reduce the maintenance prednisolone requirement of 31 patients with polymyalgia rheumatica (PMR) or giant cell arteritis (GCA), or both, was tested in a double-blind placebo controlled study over one year. Clinical and laboratory assessments were made at four-weekly intervals over a period of 52 weeks. A statistically significant difference (p less than 0.05) in mean prednisolone dose was noted between the two groups at the end of 52 weeks, there being a fall in...

  20. Pure red cell aplasia due to azathioprine therapy for Crohn′s disease

    Directory of Open Access Journals (Sweden)

    Nagesh Kamath

    2016-01-01

    Full Text Available Various mechanisms contribute to anemia in inflammatory bowel diseases (IBD, drug-related causes being less frequent. The hematological and other adverse events of azathioprine (AZA therapy are well documented, but drug-associated pure red cell aplasia (PRCA is an uncommon event. We hereby describe two cases of AZA-associated PRCA in patients with Crohn′s disease. The diagnosis was supported by pathological reports, and prompt hematological recovery was seen with discontinuation of the offending drug. This report highlights the need to consider this rare entity in IBD patients in appropriate settings and for adopting adequate precautionary measures.

  1. Fatal Epstein-Barr Virus Primo Infection in a 25-Year-Old Man Treated with Azathioprine for Crohn's Disease ▿

    OpenAIRE

    N'Guyen, Y.; Andreoletti, L; Patey, M; Lecoq-Lafon, C.; Cornillet, P; Léon, A.; Jaussaud, R.; Fieschi, C; Strady, C.

    2009-01-01

    We report a case of Epstein-Barr virus (EBV) primo infection with the development of successive infectious mononucleosis, hemophagocytic lymphohistiocytosis, and B-cell lymphoproliferative disorder in a patient treated with azathioprine for Crohn's disease. This case report suggests that specific EBV-related clinical and virological management should be considered when treating a patient with inflammatory bowel disease with azathioprine.

  2. Erfaringer med intervensjonsforsøk i yrkesepidemiologi: Basert på studier av miljøtiltak for å forbedre inneklima i kontormiljø

    Directory of Open Access Journals (Sweden)

    Knut Skyberg

    2009-10-01

    Full Text Available  SAMMENDRAGBasert på to intervensjonsforsøk rettet mot helseeffekter i hud og øvre luftveier før og etter inneklimatiltak,drøftes erfaringer med design, metoder og analyse av data. Intervensjonene som ble prøvet ut varantistatisk behandling av dataskjerm (n=117 og storrengjøring i kontormiljø (n=104. Det ble måltstøvkonsentrasjon under vanlig arbeid med direktevisende partikkelteller. Ved støvkonsentrasjoner > 50μg/m 3 hadde tiltakene effekt. Antistatisk behandling av skjermen førte til reduserte hudplager i ansiktet.Kolorimetrisk måling av rødfarge i ansiktet viste ingen forskjeller mellom intervensjon og placebo.Rengjøring av enkeltkontorer førte til reduserte slimhinneplager i øvre luftveier. Personer med tendenstil redusert nesepassasje viste økning av hulmål-parametre, målt med akustisk rhinometri. I beggeforsøk ble endring i helsevariabler før-etter i intervensjonsgruppen sammenlignet med endring ikontrollgruppen. Det konkluderes med at intervensjon som metode i arbeidsmedisinsk forskning erressurskrevende, men har en rekke fordeler som metoden deler med klinisk kontrollerte forsøk.Skyberg K, Skulberg K. Experiences from intervention trials in occupational epidemiology,based on studies of measures to improve indoor air in offices.Nor J Epidemiol ENGLISH SUMMARYBased on two intervention trials on health effects in skin and upper airways, before and after indoor airquality measures, experience with design, methods and data analysis are discussed. Applied interventionswere antistatic treatment of VDU (n=117 and comprehensive cleaning of the office (n=104. Dustconcentrations during usual work were measured, using a particle counter. The interventions showedeffect when the dust concentration was > 50 μg/m 3. Antistatic treatment of the VDU lead to reducedfacial skin symptoms. Colorimetric measurements, however, showed no differences between the interventionand control groups. Cleaning of single offices lead to a

  3. Optimizing 6-mercaptopurine and azathioprine therapy in the management of inflammatory bowel disease.

    Science.gov (United States)

    Bradford, Kara; Shih, David Q

    2011-10-01

    The thiopurine drugs, 6-mercaptopurine (6-MP) and azathioprine, are efficacious in the arsenal of inflammatory bowel disease (IBD) therapy. Previous reports indicate that 6-thioguanine nucleotide (6-TGN) levels correlate with therapeutic efficacy, whereas high 6-methylmercaptopurine (6-MMP) levels are associated with hepatotoxicity and myelotoxicity. Due to their complex metabolism, there is wide individual variation in patient response therein, both in achieving therapeutic drug levels as well as in developing adverse reactions. Several strategies to optimize 6-TGN while minimizing 6-MMP levels have been adopted to administer the thiopurine class of drugs to patients who otherwise would not tolerate these drugs due to side-effects. In this report, we will review different approaches to administer the thiopurine medications, including the administration of 6-mercaptopurine in those unsuccessfully treated with azathioprine; co-administration of thiopurine with allopurinol; co-administration of thiopurine with anti-tumor necrosis factor α; 6-TGN administration; desensitization trials; and split dosing of 6-MP. PMID:22072847

  4. Stability of acetazolamide, allopurinol, azathioprine, clonazepam, and flucytosine in extemporaneously compounded oral liquids.

    Science.gov (United States)

    Allen, L V; Erickson, M A

    1996-08-15

    The stability of drugs commonly prescribed for use in oral liquid dosage forms but not commercially available as such was studied. Acetazolamide 25 mg/mL, allopurinol 20 mg/mL, azathioprine 50 mg/mL, clonazepam 0.1 mg/mL, and flucytosine 10 mg/mL were prepared in 1:1 mixture of Ora-Sweet and Ora-Plus (Paddock Laboratories), a 1:1 mixture of Ora-Sweet SF and Ora-Plus (Paddock Laboratories), and cherry syrup and placed in polyethylene terephthalate bottles. The sources of the drugs were capsules and tablets. Six bottles were prepared per liquid; three were stored at 5 degrees C and three at 25 degrees C, all in the dark. A sample was removed from each bottle initially and at intervals up to 60 days and analyzed for drug concentration by stability-indicating high-performance liquid chromatography. At least 94% of the initial drug concentration was retained in all the oral liquids for up to 60 days. There were no substantial changes in the appearance or odor of the liquids, or in the pH. Acetazolamide 25 mg/mL, allopurinol 20 mg/mL, azathioprine 50 mg/mL, clonazepam 0.1 mg/mL, and flucytosine 10 mg/mL were stable for up to 60 days at 5 and 25 degrees C in three extemporaneously compounded oral liquids. PMID:8862208

  5. Optimizing 6-mercaptopurine and azathioprine therapy in the management of inflammatory bowel disease

    Institute of Scientific and Technical Information of China (English)

    Kara Bradford; David Q Shih

    2011-01-01

    The thiopurine drugs, 6-mercaptopurine (6-MP) and azathioprine, are efficacious in the arsenal of inflammatory bowel disease (IBD) therapy. Previous reports indicate that 6-thioguanine nucleotide (6-TGN) levels correlate with therapeutic efficacy, whereas high 6-methylmercaptopurine (6-MMP) levels are associated with hepatotoxicity and myelotoxicity. Due to their complex metabolism, there is wide individual variation in patient response therein, both in achieving therapeutic drug levels as well as in developing adverse reactions. Several strategies to optimize 6-TGN while minimizing 6-MMP levels have been adopted to administer the thiopurine class of drugs to patients who otherwise would not tolerate these drugs due to side-effects. In this report, we will review different approaches to administer the thiopurine medications, including the administration of 6-mercaptopurine in those unsuccessfully treated with azathioprine; co-administration of thiopurine with allopurinol; co-administration of thiopurine with anti-tumor necrosis factor a; 6-TGN administration; desensitization trials; and split dosing of 6-MP.

  6. Med Kingo på dybt vand

    DEFF Research Database (Denmark)

    Arndal, Lars Stubbe

    2014-01-01

    Tag med digteren Thomas Kingo ud på dybt vand i selskab med lektor og mag.art. Lars Arndal, der kaster nye perspektiver på Kingos forlisdigt Hierte-Suk. Arndal kommer hermed også med et bud på, hvordan man som lærer kan invitere eleverne med på opdagelse i digtet...

  7. Azathioprine-associated acute myeloid leukemia in a patient with Crohn's disease and thiopurine S-methyltransferase deficiency

    DEFF Research Database (Denmark)

    Yenson, P.R.; Forrest, D.; Schmiegelow, K.;

    2008-01-01

    risk of hematologic toxicity and leukemogenesis. We present such a patient who was a slow metabolizer for azathioprine, and developed a rapidly lethal form acute myeloid leukemia after relatively low dose exposure to the drug. There was prominent hemophagocytic activity in the bone marrow, and...

  8. Lack of evidence of a beneficial effect of azathioprine immune-mediated hemolytic anemia: a retrospective cohort study

    NARCIS (Netherlands)

    Piek, C.J.; Spil, Van W.E.; Junius, G.; Dekker, A.

    2011-01-01

    Background Azathioprine is used as an immunosuppressant in canine immune-mediated hemolytic anemia (IMHA), but this potentially toxic and carcinogenic drug has not been proven to be beneficial. The aim of this study was to determine the difference in outcome and survival of dogs with idiopathic IMHA

  9. Clinical and magnetic resonance imaging (MRI) findings of idiopathic aplastic pancytopenia in a dog treated with cyclosporine and azathioprine

    OpenAIRE

    Kim, Jung-Hyun; Kim, Ju-Won; Lim, Chae-Young; Park, Hee-Myung

    2012-01-01

    A dog was referred for pancytopenia. Bone marrow biopsy showed hypocellular fatty marrow. Magnetic resonance imaging had a high signal on T1-weighted image in the metaphyseal region of the femur. We suggest that MRI could be a valuable supportive diagnostic method and introduce a strategy of treatment with cyclosporine and azathioprine in canine aplastic pancytopenia.

  10. Clinical and magnetic resonance imaging (MRI) findings of idiopathic aplastic pancytopenia in a dog treated with cyclosporine and azathioprine.

    Science.gov (United States)

    Kim, Jung-Hyun; Kim, Ju-Won; Lim, Chae-Young; Park, Hee-Myung

    2012-04-01

    A dog was referred for pancytopenia. Bone marrow biopsy showed hypocellular fatty marrow. Magnetic resonance imaging had a high signal on T1-weighted image in the metaphyseal region of the femur. We suggest that MRI could be a valuable supportive diagnostic method and introduce a strategy of treatment with cyclosporine and azathioprine in canine aplastic pancytopenia. PMID:23024391

  11. Spilleregler i musikterapi med voksne

    DEFF Research Database (Denmark)

    Holck, Ulla

    Artiklen gennemgår udvalgt faglitteratur, der på et overordnet plan beskriver typer af spilleregler i musikterapi med (fortrinsvis) voksne klientgrupper. Udgangspunktet er Priestleys anvendelse af begrebet, og hendes inddeling af spilleregler i forhold til forskellige teknikker gennemgås, efterfu......Artiklen gennemgår udvalgt faglitteratur, der på et overordnet plan beskriver typer af spilleregler i musikterapi med (fortrinsvis) voksne klientgrupper. Udgangspunktet er Priestleys anvendelse af begrebet, og hendes inddeling af spilleregler i forhold til forskellige teknikker gennemgås...

  12. Datadriven beteendemodellering med genetisk programmering

    OpenAIRE

    Borak, Kim; Vilén, Gabriel

    2015-01-01

    Inom Totalförsvarets forskningsinstitut och Försvarsmakten finns behov av att enklare och mer effektivt (med avseende på kostnad och tid) kunna skapa bättre, mer realistiska och objektiva beteenden för de syntetiska aktörer som ingår i Försvarsmaktens simuleringsbaserade beslutsstöds- och träningsapplikationer. Den traditionella metoden för anskaffning av kunskap om ett beteende, vid utveckling av beteendemodeller, är att arbeta med experter inom ämnesområdet. Den här processen är ofta tidskr...

  13. Arbejdet med at optimere arbejdet

    DEFF Research Database (Denmark)

    Lystbæk, Christian Tang

    2014-01-01

    Optimering har en lang historie i arbejdslivet. Artiklen analyserer forskydninger i semantikkerne og teknikkerne omkring arbejdet med at optimere arbejdet i Human Resource Management. I HRM-litteraturen er det udbredt at skelne mellem to forskellige tilgange til arbejdet med at optimere arbejdet...... som et potentiale, der skal udvikles gennem løbende kompetenceudvikling i arbejdslivet. Ofte betegnes disse ofte for en ”hård” hhv. ”blød” tilgang (Storey 1992) eller en ”high performance” hhv. ”high commitment” tilgang til HRM (Legge 2005). Nærværende artikel videreudvikler denne analyse ved at...

  14. Ud at se med Erasmus

    DEFF Research Database (Denmark)

    Frandsen, Pernille

    2009-01-01

    Få lidt luft under vingerne, kom ud at møde udenlandske kolleger og se, hvordan man også kan lave uddannelsesbibliotek. Med begejstring fortæller tre bibliotekarer om deres oplevelser i det store udland – alt sammen finansieret af Erasmus.......Få lidt luft under vingerne, kom ud at møde udenlandske kolleger og se, hvordan man også kan lave uddannelsesbibliotek. Med begejstring fortæller tre bibliotekarer om deres oplevelser i det store udland – alt sammen finansieret af Erasmus....

  15. Symfoniorkestrets instrumenter med aktive elever

    DEFF Research Database (Denmark)

    Okkels, Else Marie

    Eleverne lærer symfoniorkestrets instrumenter at kende på en ny og spændende måde.Bl.a.instrumentbanko med klang; der er spilleplader til kopiering og "brikker" i lyd på den indlagte cd.......Eleverne lærer symfoniorkestrets instrumenter at kende på en ny og spændende måde.Bl.a.instrumentbanko med klang; der er spilleplader til kopiering og "brikker" i lyd på den indlagte cd....

  16. Informationsledelse med mindset-map

    DEFF Research Database (Denmark)

    Brodersen, Lars

    Teorien og modellerne om informationsledelse med mindset-map bygger på Aalborg Universitets PBL-model, naturvidenskabelige principper, tekniske principper og humanistiske teorier. I kombination udgør disse grundlag et stærkt grundlag, som sikrer resultater. Informationsledelse handler om projektf......Teorien og modellerne om informationsledelse med mindset-map bygger på Aalborg Universitets PBL-model, naturvidenskabelige principper, tekniske principper og humanistiske teorier. I kombination udgør disse grundlag et stærkt grundlag, som sikrer resultater. Informationsledelse handler om...

  17. Faldgruber ved investering med garanti

    DEFF Research Database (Denmark)

    Grosen, Anders

    Investeringsprodukter med garanti for et vist minimumsafkast er efterspurgt blandt private investorer. Men pga. produkternes faldgruber ender de ofte på avisernes forsider. Det seneste eksempel har Sampension leveret. Overskrifterne kom i hus ved Sampensions melding om at droppe kundernes pension...

  18. Unges friluftsliv set med integrationsbriller

    DEFF Research Database (Denmark)

    Gentin, Sandra

    Det er almindelig kendt, at indvandrere ikke deltager i foreningsliv i samme omfang som etniske danskere. Det er der forsøgt rådet bod på ved at invitere unge med anden etnisk baggrund end dansk til at dyrke spejdersport i henholdsvis Varde og København NV. Tilgangen til at integrere de unge var...

  19. Et eller andet med sprog

    DEFF Research Database (Denmark)

    Adamsen, Billy; Nielsen, Charlotte Marie Bisgaard; Dam Christensen, Mie;

    2012-01-01

    Sprogpsykologi har eksisteret som kandidat-uddannelse på Københavns Universitet i 40 år og har i øjeblikket 162 studerende. Deres baggrund er som regel en bachelor i sprog, sociologi, lingvistik eller retorik. - Hvad studerer man på Sprogpsykologi? - Aner det ikke. Er det noget med sprog og menne...

  20. Overview of the MEDLI Project

    Science.gov (United States)

    Gazarik, Michael J.; Little, Alan; Cheatwood, F. Neil; Wright, Michael J.; Herath, Jeff A.; Martinez, Edward R.; Munk, Michelle; Novak, Frank J.; Wright, Henry S.

    2008-01-01

    The Mars Science Laboratory Entry, Descent, and Landing Instrumentation (MEDLI) Project s objectives are to measure aerothermal environments, sub-surface heatshield material response, vehicle orientation, and atmospheric density for the atmospheric entry and descent phases of the Mars Science Laboratory (MSL) entry vehicle. The flight science objectives of MEDLI directly address the largest uncertainties in the ability to design and validate a robust Mars entry system, including aerothermal, aerodynamic and atmosphere models, and thermal protection system (TPS) design. The instrumentation suite will be installed in the heatshield of the MSL entry vehicle. The acquired data will support future Mars entry and aerocapture missions by providing measured atmospheric data to validate Mars atmosphere models and clarify the design margins for future Mars missions. MEDLI thermocouple and recession sensor data will significantly improve the understanding of aeroheating and TPS performance uncertainties for future missions. MEDLI pressure data will permit more accurate trajectory reconstruction, as well as separation of aerodynamic and atmospheric uncertainties in the hypersonic and supersonic regimes. This paper provides an overview of the project including the instrumentation design, system architecture, and expected measurement response.

  1. Privat voldgift med offentligretlige delspørgsmål

    DEFF Research Database (Denmark)

    Werlauff, Erik

    2008-01-01

    Artiklen behandler de offentligretlige delspørgsmål, der kan opstå under en voldgiftssag, fx vedrørende el-, varme-, naturgas- og anden forsyningslovgivning, national eller fællesskabsretlig konkurrencelovgivning, forskrifter om statsforvaltningens godkendelse af vilkårene for udtræden af...

  2. Arbejdsret med tilknyttede dele af socialretten og skatteretten

    DEFF Research Database (Denmark)

    Hasselbalch, Ole

    Indeholder en systematisk udtømmende gennemgang af hele arbejdsretsordningen. I første del behandles de almene problemer, herunder den historiske udvikling, organisationsvæsenet, retskilderne, tvisteløsningssystemerne, internationalt arbejdsretlige forhold m.v. Anden del tager retsforholdet melle...

  3. Fang CO2 med Aminosyrer

    DEFF Research Database (Denmark)

    Lerche, Benedicte Mai

    2010-01-01

    Med såkaldte “carbon capture-teknikker” er det muligt at rense røgen fra kulfyrede kraftværker, således at den er næsten helt fri for drivhusgassen CO2. Kunsten er at gøre processen tilstrækkeligt billig. Et lovende fangstredskab i denne proces er aminosyrer.......Med såkaldte “carbon capture-teknikker” er det muligt at rense røgen fra kulfyrede kraftværker, således at den er næsten helt fri for drivhusgassen CO2. Kunsten er at gøre processen tilstrækkeligt billig. Et lovende fangstredskab i denne proces er aminosyrer....

  4. EULAR randomised controlled trial of pulse cyclophosphamide and methylprednisolone versus continuous cyclophosphamide and prednisolone followed by azathioprine and prednisolone in lupus nephritis

    OpenAIRE

    Yee, C; Gordon, C.; Dostal, C.; Petera, P; Dadoniene, J; Griffiths, B; Rozman, B; Isenberg, D; Sturfelt, G; NIVED, O.; Turney, J.; Venalis, A; Adu, D.; Smolen, J.; Emery, P.

    2004-01-01

    Objective: To compare the efficacy and side effects of intermittent pulse cyclophosphamide plus methylprednisolone with continuous oral cyclophosphamide plus prednisolone, followed by azathioprine, in patients with proliferative glomerulonephritis caused by systemic lupus erythematosus (SLE).

  5. Human melioidosis reported by ProMED

    Directory of Open Access Journals (Sweden)

    Katherinn Melissa Nasner-Posso

    2015-06-01

    Conclusions: Internet-based reporting systems such as ProMED are useful to gather information and synthesize knowledge on emerging infections. Although certain areas need to be improved, ProMED provided good information about melioidosis.

  6. Unge homofile med minoritetsbakgrunn: En kvalitativ studie med sju lesbiske og homofile med minoritetsbakgrunn i Norge

    OpenAIRE

    Øvergaard, Georgina Demou

    2013-01-01

    Denne studien fokuserer på livssituasjonen til unge homofile med minoritetsbakgrunn bosatt i Norge. Fokuset er på hvilke identitetsrelaterte utfordringer en slik posisjon kan eller vil medføre, hvilken innvirkning stigma har, og hvordan ulike utfordringer håndteres ved hjelp av strategier. Det sentrale teoretiske perspektivet i denne studien er hentet fra Erwin Goffman og hans stigmateori. Hans konsepter av "den stigmatiserte", "de normale", og faktisk og tilsynelatende identitet benyttes for...

  7. Eudragit-S, Eudragit-L and cellulose acetate phthalate coated polysaccharide tablets for colonic targeted delivery of azathioprine.

    Science.gov (United States)

    Kotagale, Nandkishor; Maniyar, Mithun; Somvanshi, Sachin; Umekar, Milind; Patel, Chirag J

    2010-01-01

    The present work deals with the formulation and evaluation of polymer-coated polysaccharide tablets of azathioprine prepared by direct compression method using different ratios of avicel (MCC), inulin and triacetin. The tablets formulations containing 25 mg of azathioprine were prepared and evaluated for thickness, hardness, friability, weight variation, content uniformity and in vitro dissolution test. Hardness and percentage friability were in the range of 7.23-7.43 kg/cm(2) and 0.21-0.41%, respectively, and showed 99-100% uniformity in drug content. The coated tablets exploiting different polymer combinations were evaluated for drug release under different pH conditions. The formulation containing Eudragit-S, Eudragit-L and cellulose acetate phthalate (ES, EL and CAP) (1:1:1) displayed desired release pattern with only 9.75% drug release in first 5 h (lag phase) and satisfactory release in lowered pH conditions. Drug release increased with the plasticizer (triacetin) concentration. Increase in the concentration of inulin and citric acid above 5% w/w increases the drug release. The addition of inulin in the formulation with coating level 28% w/w demonstrated increased drug release in presence of rat cecal content. Thus inulin containing ES, EL and CAP (1:1:1) polymer-coated formulation system can be used for the targeted delivery of azathioprine with desired release pattern. PMID:20236031

  8. Successful low-dose azathioprine for myasthenia gravis despite hepatopathy from primary sclerosing cholangitis: a case report

    Directory of Open Access Journals (Sweden)

    Höflich Sonja

    2010-11-01

    Full Text Available Abstract Introduction Although myasthenia gravis is frequently associated with other disorders, it has not been reported together with primary sclerosing cholangitis, complicating the administration of liver-toxic immunosuppressive therapy. Case presentation A 73-year-old Caucasian woman with a history of arterial hypertension, thyroid dysfunction, glaucoma, right-sided ptosis and later generalized weakness, was diagnosed with myasthenia gravis. Additionally, primary sclerosing cholangitis was detected, initially prohibiting the administration of immunosuppressants. Despite treatment with steroids and pyridostigmine she repeatedly experienced myasthenic crises. After the fifth crisis and after antibody titers had reached levels > 100 nmol/L during two years of follow-up, it was decided to restart azathioprine. Interestingly, low-dose azathioprine (1.5 mg/kg/day was well tolerated, had a positive clinical and immunological effect and did not worsen primary sclerosing cholangitis. Conclusion Myasthenia gravis may occur together with primary sclerosing cholangitis in the same patient. Mild immunosuppression with azathioprine is feasible and effective in such a patient, without worsening myasthenia gravis or primary sclerosing cholangitis.

  9. Holocaust : med internett som kilde

    OpenAIRE

    Schønningsen, Patrick

    2012-01-01

    Masteroppgaven tar for seg holocaust med internett som kilde. Jeg tar utgangspunkt i ungdomsskole og videregående. Hvordan skal elevene forholde seg til internettet. Er det stor sannsynelighet for at elevene vil møte på holocaustfonektelse på nettet? Hvordan lære elevene å være kritisk til nettet? Jeg deler holocaust inn i 5 kategorier. Hvor kategori 1 er av de svært rasistiske nettsidene som ønsker at jødene skal utryddes. Kategori 3 tar for seg revisjonisme. Kategori 4 er forumer som diskut...

  10. ZASVOJENOST Z INTERNETOM MED MLADIMI

    OpenAIRE

    Rihtarič, Mitja

    2015-01-01

    Teoretična izhodišča: Internet nam je danes dosegljiv na vsakem koraku in nam tako olajša vsakdanja opravila. Postal je tudi idealno sredstvo za preživljanje prostega časa, sploh med mladimi. Prekomerno posvečanje aktivnostim na internetu, lahko privede do zasvojenosti. Mladi so v času adolescence močno izpostavljeni različnim dejavnikom in internet močno vpliva na izoblikovanje njihove osebnosti. V diplomskem delu smo opisali zasvojenost in podrobneje raziskali zasvojenost z internetom. R...

  11. Evaluation of Azathioprine-Induced Cytotoxicity in an In Vitro Rat Hepatocyte System

    Directory of Open Access Journals (Sweden)

    Abdullah Al Maruf

    2014-01-01

    Full Text Available Azathioprine (AZA is widely used in clinical practice for preventing graft rejection in organ transplantations and various autoimmune and dermatological diseases with documented unpredictable hepatotoxicity. The potential molecular cytotoxic mechanisms of AZA towards isolated rat hepatocytes were investigated in this study using “Accelerated Cytotoxicity Mechanism Screening” techniques. The concentration of AZA required to cause 50% cytotoxicity in 2 hrs at 37°C was found to be 400 μM. A significant increase in AZA-induced cytotoxicity and reactive oxygen species (ROS formation was observed when glutathione- (GSH- depleted hepatocytes were used. The addition of N-acetylcysteine decreased cytotoxicity and ROS formation. Xanthine oxidase inhibition by allopurinol decreased AZA-induced cytotoxicity, ROS, and hydrogen peroxide (H2O2 formation and increased % mitochondrial membrane potential (MMP. Addition of N-acetylcysteine and allopurinol together caused nearly complete cytoprotection against AZA-induced hepatocyte death. TEMPOL (4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl, a known ROS scavenger and a superoxide dismutase mimic, and antioxidants, like DPPD (N,N′-diphenyl-p-phenylenediamine, Trolox (a water soluble vitamin E analogue, and mesna (2-mercaptoethanesulfonate, also decreased hepatocyte death and ROS formation. Results from this study suggest that AZA-induced cytotoxicity in isolated rat hepatocytes may be partly due to ROS formation and GSH depletion that resulted in oxidative stress and mitochondrial injury.

  12. Should 6-thioguanine nucleotides be monitored in heart transplant recipients given azathioprine?

    Science.gov (United States)

    Schütz, E; Gummert, J; Mohr, F W; Armstrong, V W; Oellerich, M

    1996-06-01

    The commonly used immunosuppressive regimen after orthotopic heart transplantation consists of cyclosporine (CsA), azathioprine (AZA), and steroids. Although AZA therapy is generally regarded as unproblematic, its use can be associated with severe side effects, particularly myelosuppression. Since AZA is a prodrug, which must first be metabolized to its active metabolites, AZA therapy, in contrast to CsA therapy, cannot be controlled by measuring blood levels of this drug. Because of the myelosuppressive properties of the AZA metabolites, the 6-thioguanine nucleotides (6-TGN), the white blood cell count is usually monitored in patients on AZA therapy, and AZA is discontinued if neutropenia appears. In a group of 20 consecutive heart recipients, 6-TGN concentrations ranged from allopurinol, an inhibitor of xanthine oxidase, the other major detoxifying enzyme for AZA. In this patient AZA therapy could be individually adapted by RBC 6-TGN monitoring. Based on our experience, we suggest that RBC 6-TGN monitoring allows for better individualization of treatment with AZA and may help avoid fatal complications. PMID:8738760

  13. Evaluation of azathioprine-induced cytotoxicity in an in vitro rat hepatocyte system.

    Science.gov (United States)

    Al Maruf, Abdullah; Wan, Luke; O'Brien, Peter J

    2014-01-01

    Azathioprine (AZA) is widely used in clinical practice for preventing graft rejection in organ transplantations and various autoimmune and dermatological diseases with documented unpredictable hepatotoxicity. The potential molecular cytotoxic mechanisms of AZA towards isolated rat hepatocytes were investigated in this study using "Accelerated Cytotoxicity Mechanism Screening" techniques. The concentration of AZA required to cause 50% cytotoxicity in 2 hrs at 37°C was found to be 400 μM. A significant increase in AZA-induced cytotoxicity and reactive oxygen species (ROS) formation was observed when glutathione- (GSH-) depleted hepatocytes were used. The addition of N-acetylcysteine decreased cytotoxicity and ROS formation. Xanthine oxidase inhibition by allopurinol decreased AZA-induced cytotoxicity, ROS, and hydrogen peroxide (H2O2) formation and increased % mitochondrial membrane potential (MMP). Addition of N-acetylcysteine and allopurinol together caused nearly complete cytoprotection against AZA-induced hepatocyte death. TEMPOL (4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl), a known ROS scavenger and a superoxide dismutase mimic, and antioxidants, like DPPD (N,N'-diphenyl-p-phenylenediamine), Trolox (a water soluble vitamin E analogue), and mesna (2-mercaptoethanesulfonate), also decreased hepatocyte death and ROS formation. Results from this study suggest that AZA-induced cytotoxicity in isolated rat hepatocytes may be partly due to ROS formation and GSH depletion that resulted in oxidative stress and mitochondrial injury. PMID:25101277

  14. Pulmonary infection in patients with cyclosporine, azathioprine, and corticosteroids after cardiac transplantation; Clinical and radiographic assessment

    Energy Technology Data Exchange (ETDEWEB)

    Murayama, Sadayuki; Ikezoe, Junpei; Godwin, J.D.; Marglin, S.I.; Allen, M.D. (University of Washington Medical Center, Seattle, WA (United States))

    1991-07-01

    Between November 1985 and November 1989, 54 patients have undergone 55 cardiac transplants, 5 of whom died during operation or one week after transplantation. The remaining 49 patients with a minimum follow-up of 5 months were studied to examine pulmonary infection clinically and radiologically while receiving triple drug immunosuppression consisting of cyclosporine, azathioprine, and prednisolone. Pulmonary infection occurred in 14 patients (29%) with a total of 21 occasions. Causative organisms were identified in 9 occasions, with the most common organism being Cytomegalovirus (CMV). One patient died of pulmonary infection with Aspergillus. Causative organisms occurring in the remaining 12 occasions of pulmonary infection were unknown, which did not lead to death. Because pulmonary infection of unknown organisms rapidly responded to convensional antibiotics, it seemed to have been caused by bacteria. Pulmonary infection of unknown organism occurred 13.2{+-}3.2 months after transplantation, as compared with 3.3{+-}1.0 months in pulmonary infection of known organisms. Chest plain radiographic features fell into four types: (1) interstitial shadow seen in pulmonary infection of CMV, Pneumocystis carinii, or Hemophilia influenza, (2) patchy, and basilar and lobular consolidation shadows in bacterial pneumonia, (3) localized nodular shadow in aspergillosis, and (4) multiple patchy and confluent opacity patterns occurring in herpes simplex viral infection. Pulmonary infection of influenza bacteria for one patient and pulmonary infection of unknown organisms for 4 patients were difficult to identify from pulmonary infection of CMV. (N.K.).

  15. Radioactive Iodo-azathioprine as a possible model for cancer imaging and therapy

    International Nuclear Information System (INIS)

    Azathioprine (Aza) is antimetabolite drug, could be labeled with the auger emitters iodine-125. Aza could be used an ideal vehicle to deliver radioactive decay energy to DNA of tumor cells causing DNA double strand break, thus stop DNA synthesis. In this study, the process of labeling was done via direct labeling technique using chloramine-T as an oxidizing agent and heating to 75 degree C, for 30 minutes at ph using 0.5 M phosphate buffer. The radiochemical purity of the labeled compound, at the above conditions, was determined using electrophoresis technique and was above 90%. About 2.5x106 of enrich ascites carcinoma (EAC) was injected intraperitoneally(i.p) to produce ascites and intramuscularly (i.m) in the right thigh to produce solid tumor in female mice. Biodistribution studies were carried out by injecting solution of 125I-aza in normal and tumor bearing mice. The uptake in ascites was over 40 % of the injected dose at 12 h post injection and above 20 % in solid tumor . These data revealed localization of the tracer in the tumor tissues with high percentage sufficient to give radiotherapeutic effect as well as promising tool for diagnosis.

  16. Non-TPMT determinants of azathioprine toxicity in inflammatory bowel disease

    Directory of Open Access Journals (Sweden)

    K. Katsanos

    2010-04-01

    Full Text Available Azathioprine (AZA follows three metabolic routes: the first is the route to 6-thioguanine (TGN catalyzed by thiopurine methyltransferase (TPMT and the other two routes are S-methylation to methylmercaptopurine catalyzed also by TPMT or oxidation to thiouric acid via the enzyme xanthine oxidase. Bone marrow toxicity (BMT mainly in the form of leucopenia represents a major adverse event during AZA therapy in inflammatory bowel disease (IBD. Single nucleotide polymorphisms (SNPs in the TPMT gene locus affecting 6-TGN intracellular accumulation play a significant role in the occurrence of side effects including BMT. Conflicting data exist regarding the role of TPMT genotyping or TPMT enzyme activity in predicting AZA toxicity. Although some BMT cases can be explained by TPMT genotyping or enzyme activity in the majority of cases BMT remains unexplained. These limitations in TPMT testing pointed out to other genes involved in AZA metabolization. Many non-TPMT genes were investigated but their clinical importance is controversial. To explore the applicability of TPMT and non-TPMT genotyping for AZA toxicity monitoring, large prospective studies are needed. Until the results of such studies are available, the dose adjustments of AZA should be guided primarily by clinical response and peripheral blood counts.

  17. Pulmonary infection in patients with cyclosporine, azathioprine, and corticosteroids after cardiac transplantation

    International Nuclear Information System (INIS)

    Between November 1985 and November 1989, 54 patients have undergone 55 cardiac transplants, 5 of whom died during operation or one week after transplantation. The remaining 49 patients with a minimum follow-up of 5 months were studied to examine pulmonary infection clinically and radiologically while receiving triple drug immunosuppression consisting of cyclosporine, azathioprine, and prednisolone. Pulmonary infection occurred in 14 patients (29%) with a total of 21 occasions. Causative organisms were identified in 9 occasions, with the most common organism being Cytomegalovirus (CMV). One patient died of pulmonary infection with Aspergillus. Causative organisms occurring in the remaining 12 occasions of pulmonary infection were unknown, which did not lead to death. Because pulmonary infection of unknown organisms rapidly responded to convensional antibiotics, it seemed to have been caused by bacteria. Pulmonary infection of unknown organism occurred 13.2±3.2 months after transplantation, as compared with 3.3±1.0 months in pulmonary infection of known organisms. Chest plain radiographic features fell into four types: (1) interstitial shadow seen in pulmonary infection of CMV, Pneumocystis carinii, or Hemophilia influenza, (2) patchy, and basilar and lobular consolidation shadows in bacterial pneumonia, (3) localized nodular shadow in aspergillosis, and (4) multiple patchy and confluent opacity patterns occurring in herpes simplex viral infection. Pulmonary infection of influenza bacteria for one patient and pulmonary infection of unknown organisms for 4 patients were difficult to identify from pulmonary infection of CMV. (N.K.)

  18. Azathioprine as a single immunosuppressive drug in the treatment of myasthenia gravis.

    Science.gov (United States)

    Cosi, V; Lombardi, M; Erbetta, A; Piccolo, G

    1993-04-01

    We retrospectively evaluated results obtained from azathioprine (AZA) treatment on a selected sample of 40 patients affected by autoimmune myasthenia gravis (MG). Patients received AZA as a single immunosuppressive drug for at least 2 years. Twenty out of 40 patients received also a one-month course of cyclophosphamide (CP) before starting AZA. All patients started immunosuppressive treatment out of myasthenic crisis. After 3, 12 and 24 months of AZA treatment, 82.5%, 92.5% and 97.5% of the patients respectively showed improvement in functional state, disappearance of bulbar involvement, or both. The impressive percentage of short-term positive results did not seem influenced by pre-treatment by CP. Side effects included only minor and transitory gastrointestinal symptoms and reversible cytopenia. Although the patient population was either particularly suitable for AZA treatment or candidate to a better response, our data suggest that AZA might also have good short term effects in a subgroup of MG patients. PMID:8328322

  19. MED-SUV Data policy

    Science.gov (United States)

    Sangianantoni, Agata; Puglisi, Giuseppe

    2014-05-01

    MED-SUV proposes the development and implementation of a digital infrastructure for data access and for volcanic risk management aimed at applying the rationale of Supersites GEO initiative to Campi Flegrei/Vesuvius and Mt. Etna. It's fully recognized the clear need of an open data policy in order to ensure that data will be properly and in an ethical manner managed and can be used and accessed from its community. In MED-SUV there is a multitude of different partners with varying scientific, technical, legal and economical interests and therefore data and data products produced will be wide-ranging so it's necessary to set principles and legal arrangements. Within Europe several Directives and Regulations have brought into force which provide the leading guidelines in terms of the principle of openness to knowledge and access to scientific information. So in creating a suite policy the EC Supersites (MarSite and FutureVolc, under the EPOS umbrella) projects need to strength their efforts in defining a common data management strategy. In this presentation we will show the leading principles of the data policy, as for instance Open Access, flexibility of approach in order to harmonize the different methods of data distribution among its partners, Creative Commons licensing, data preservation and unique identification through Persistent Identifiers.

  20. Behandling av reinkalver med ivermectin første levehøst. Effekt på levendevekter andre levehøst

    Directory of Open Access Journals (Sweden)

    Eirik Heggstad

    1986-06-01

    Full Text Available Reinen lever i et svært sårbart miljø, hvor små inngrep kan gi uante følger på lengre sikt. Innføring av medikamentbruk i en næring som tradisjonelt har klart seg uten medfører derfor et betydelig ansvar. For eksempel vil bruk av ivermectin på flokker fra dårlige, overbelastede beiter sannsynligvis gi bra effekt, men samtidig kan det bidra til å kamuflere problemer som kunne løses på annen måte, f.eks. ved omlegging av flokkstruktur og slakteuttak. Imidlertid vil bruk av ivermectin i reinflokker som lever under normalt gode betingelser kunne gi et resultat i form av økt kjøttavkastning som gjør at et evt. rutinemessig behandlingsopplegg vil kunne være økonomisk fordelaktig.

  1. Præhospital behandling af svært tilskadekomne patienter med fokus på damage control-kirurgi

    DEFF Research Database (Denmark)

    Sørensen, Anne Marie; Larsen, Claus Falck; Steinmetz, Jacob

    2011-01-01

    The majority of patients undergoing damage control surgery initially receive prehospital treatment. Bleeding causes 40% of trauma deaths, half of which happen in the prehospital setting. Future research and improved treatment before hospital admission should focus on control of the bleeding......, avoidance of hypothermia, minimising the time to definitive surgery, and a restrictive and goal directed therapy with regard to the intake of fluids. On occasion, lifesaving procedures could be performed during transport to the hospital....

  2. Jämförelse mellan BKR/BSK och Eurokoders behandling av utmattning i traversbalkar med tillhörande svetsfogar

    OpenAIRE

    Woll, Joakim; Åberg, Max

    2012-01-01

    This report has been performed for WSP Construction Design located at Arenavägen 7 in Stockholm. WSP Construction Design is one of the leading departments in Sweden in construction solutions regarding everything from building construction to industrial building. Great competencies regarding steel, wood and concrete constructions are available within the department which is well sought. Crane girders used in the industry are exposed to large loads that vary over time that includes instantaneou...

  3. Patienter med basalcellenævussyndrom bør tilbydes tidlig interdisciplinær opfølgning og behandling

    DEFF Research Database (Denmark)

    Bay, Christiane; Ousager, Lilian Bomme; Jelsig, Anne Marie

    2016-01-01

    Basal cell naevus syndrome (Gorlin-Goltz syndrome) is a rare, autosomal dominantly inherited condition with a wide range of developmental and multiple organ-related anomalies. Cardinal features include multiple basal cell carcinomas, jaw cysts, palmoplantar pits and calcification of the falx...... cerebri. Other important clinical features are skeletal abnormalities and facial dysmorphism including macrocephaly. Germ-line mutations are found in PTCH1. Management of the syndrome requires a multidisciplinary approach, and in this article management guidelines are reviewed and discussed....

  4. Rusmisbruk, angst og depresjon etter 10 år: En prospektiv undersøkelse av stoffmisbrukere med og uten LAR-behandling

    Directory of Open Access Journals (Sweden)

    Ravndal Edle

    2015-12-01

    Full Text Available Substance abuse, anxiety and depression after 10 years: A prospective study of drug users in and outside OMT treatment AIMS - The national Opiate Maintenance Treatment (OMT program in Norway started officially in 1998. The same year a treatment study was initiated, including the most used treatment measures for drug users in Norway. The main aim in the present study was to investigate the prevalence of live OMT patients in the total sample after 10 years, and to compare the outcome of primarily substance abuse, anxiety and depression among OMT patients versus non-OMT patients. DESIGN & METHODS - Four hundred and seven patients, in Oslo and the nearby regions, who started in 16 different in- and outpatients programs, were followed from intake to treatment and during ten years (1998-2009. Patients in the sample were interviewed after one, two, seven and ten years, and they were divided into three different treatment groups: inpatient residency for grown-ups, outpatient psychiatric youth teams and youths living in collectives. Data was collected through use of EuropASI and HSCL-25 at all follow-ups. RESULTS - After ten years 15 % were deceased. Of the 333 persons left, 73 % (n=248 were interviewed after ten years. Forty percent (n=99 were then in OMT. After ten years there were no gender differences regarding attendance to OMT, but the OMT-group was older (30 vs .28 yrs, p<0.05, and they used more benzodiazepines (p<0.000 and cannabis (p<0.01 than the others. The OMT-group reported to a larger extent more anxiety and depression throughout the total observation period than the non OMT participants. Use of heroin and criminality were significantly reduced in both groups. CONCLUSIONS - In spite of reduced use of heroin, the OMT patients seemed to have more difficulties in reducing the use of benzodiazepines and cannabis, whereas the anxiety and depression scores were high and stable through the total observation time.

  5. Mænd med rejsningsbesvær efter radikal prostatektomi bør behandles efter sædvanlige retningslinjer

    DEFF Research Database (Denmark)

    Fode, Mikkel; Hansen, Rikke Bølling; Maigaard, Thomas; Sønksen, Jens

    method is effective in animal models, but the results cannot be confirmed in humans. At this time, treatment regimens which actually create erections and allow for sexual intercourse following surgery should be prescribed. These include PDE5 inhibitors, vacuum erection devices, injection therapy...

  6. Mænd med rejsningsbesvær efter radikal prostatektomi bør behandles efter sædvanlige retningslinjer

    DEFF Research Database (Denmark)

    Fode, Mikkel; Hansen, Rikke Bølling; Maigaard, Thomas; Sønksen, Jens

    2015-01-01

    method is effective in animal models, but the results cannot be confirmed in humans. At this time, treatment regimens which actually create erections and allow for sexual intercourse following surgery should be prescribed. These include PDE5 inhibitors, vacuum erection devices, injection therapy...

  7. OPUS: Randomiseret multicenterundersøgelse af integreret behandling sammenlignet med standardbehandling før første psykoseepisode--sekundaerpublikation

    DEFF Research Database (Denmark)

    Nordentoft, Merete; Petersen, Lone; Jeppesen, Pia;

    2006-01-01

    A total of 547 patients with first-episode psychosis were included in a randomised clinical trial comparing integrated treatment with standard treatment. The integrated treatment consisted of assertive community treatment with programmes for family involvement and social skills training. Patients...

  8. Nyttan med Revision : Med fokus på "kundnytteaspekter"

    OpenAIRE

    Mistry, Vibhuti; Avdija, Besnik

    2011-01-01

    Sammanfattning Den 1 november 2010 avskaffades revisionsplikten som innebär att 72 % av aktiebolagen i Sverige har berörts av den nya lagen. Detta medför till att valmöjligheten för fri revision är öppen för privata aktiebolag som underskrider gränsvärdet. Lagen om frivillig revision har påverkat revisorns roll och ansvar samtidigt som själva yrket har förändrats och gått mer mot rådgivning. Därmed har det blivit viktigt att klargöra nyttan med revision för att kunna visa värdet för småföreta...

  9. Stormfuld vandretur med nymodens teknik

    DEFF Research Database (Denmark)

    Nielsen, Niels Christian

    2008-01-01

    Lørdag den 1. marts 2008 havde en af vores samarbejdspartnere, Miljøforeningen på Fanø havde inviteret til vandretur ad Hjertestien ved Nordby. Vi benyttede lejligheden til at afprøve GPS-udstyr, der var anskaffet til ToLearn projektet, mhp. introduktion af nye steds-baserede teknologier og medie...... i turisme og kulturformidling. Forsøget lykkedes, da de indhentede geografiske data var af tilstrækkelig præcision, og da det med brug af frit tilgængeligt software lod sig gøre at lave grafisk tilfredsstillende illustrationer til brug i den lokale presse. Udgivelsesdato: 13/3 2008...

  10. REPORT: BioMedBridges standards workshop

    OpenAIRE

    Conte, Nathalie; Hancocks, Tom; Suhr, Stephanie

    2014-01-01

    This workshop, co-organized by BioMedBridges WP3 and 12, was held on 24-25 June and hosted by BioMedBridges partners at VUMC in Amsterdam. Attendees included BioMedBridges personnel, members from the ESFRI BMS research infrastructures and invited external experts from existing standards organisations. The following aspects of data standardisation were explored: Defining entity identifiers and identifiers best practice Development of a Meta models and Mappings Registry for bio...

  11. Reflektion over diskrimination af personer med fedme

    OpenAIRE

    Overbye, Adam Brandt; Møller-Nybye, Andreas; Lysell, Jimmy René; Bunch-Nielsen, Jonathan; Knudsholt, Martin; Commerou, Peter Winther; Papanikolaou, Phoivos Apollon

    2008-01-01

    Fedme er et voksende problem ikke kun i den vestlige verden men også i udviklingslande. Problemet har nået det punkt, hvor det kan kaldes en epidemi. I takt med udbredelsen af fedme er et interessant spørgsmål opstået med hensyn til forskelsbehandlingen af personer med fedme. I hvilken grad er denne forskelsbehandling diskriminerende eller legitim? Der forelægger ingen dokumentation for diskrimination af fedme, men der er dokumentation for fordomme mod personer med fedme. I denne rapport vil ...

  12. Alterations in rat pulmonary macrophage function by the immunosuppressive agents cyclosporine, azathioprine, and prednisolone.

    Science.gov (United States)

    Drath, D B; Kahan, B D

    1983-06-01

    Disturbances of the immune response of the lung induced by the action of immunosuppressive agents on the functional abilities of rat pulmonary alveolar macrophages (PAM) were analyzed following in vitro incubation or in vivo administration (for 30 days) of cyclosporinea, (CsA) azathioprine (Az) or prednisolone (Pr). Two major parameters were analyzed: oxygen consumption and superoxide release as indices of the overall state of oxygen metabolism of these cells reflecting the integrity of PAM oxidative mechanisms of microbicidal activity, and chemotaxis, an event clinically important for normal defense to infection. In vitro incubation with cyclosporine at concentrations as low as 10(-9) M caused a 52% inhibition of PAM superoxide release, but Az had no effect at concentrations up to 10(-6) M. Prednisolone caused a 38% inhibition of superoxide release; comparable levels of inhibition with Pr required concentrations at least 10-fold greater than with cyclosporine. Further experiments indicated that cyclosporine induced a 40% inhibition after contact with PAM for only 30 min. In vivo experiments indicated that cyclosporine (5 mg/kg), Az (20 mg/kg), or Pr (2 or 0.5 mg/kg) administered intraperitoneally had no effect on the number of PAM available for host defense, PAM oxygen consumption, or PAM superoxide release. However, PAM from cyclosporine-treated animals demonstrated complete inhibition of active migration or chemotaxis in modified Boyden chambers upon incubation with formylmethionyl-leucyl-phenylalanine (FMLP). The effect was apparently dampened by simultaneous administration of Pr with cyclosporine. These experiments suggest that with the exception of a marked effect on chemotaxis the in vivo effects of physiologic amounts of cyclosporine on PAM function are modest compared with the marked depression after in vitro addition. PMID:6306880

  13. Generalized Pyoderma Gangrenosum Associated with Ulcerative Colitis: Successful Treatment with Infliximab and Azathioprine.

    Science.gov (United States)

    Chatzinasiou, Foteini; Polymeros, Dimitrios; Panagiotou, Maro; Theodoropoulos, Konstadinos; Rigopoulos, Dimitrios

    2016-04-01

    Pyoderma gangrenosum (PG) is a rare ulcerative skin disease, part of the spectrum of neutrophilic and auto-inflammatory dermatoses. Its pathogenesis is unknown, although immune pathways have been implicated. Lesion biopsies show a predominantly neutrophilic infiltrate. The incidence of PG is uncertain, but it is estimated to be 3-10 per million per year, occurring at any age but most commonly between 20 and 50 years with a possible slightly higher incidence in women. Approximately 50% of patients with PG also have another disease associated with PG. The most common is inflammatory bowel disease (IBD), particularly Crohn's and ulcerative colitis (UC). Local treatment may be sufficient for mild cases, while for severe cases systemic immunosuppressants are the mainstay (1,2). We report the case of a patient with bullous PG and UC successfully treated with infliximab and azathioprine. A 32-year-old male Caucasian patient presented with painful violaceous vesicles and enlarging bullae of various sizes and with acute onset, located on the trunk and bilaterally on both the lower and the upper extremities. Lesions on the trunk were composed of hemorrhagic pustules with a surrounding erythematous overhanging border. Some of the lesions had undergone central necrosis and ulceration (Figure 1, a-d). The patient reported of the lesions had appeared one week ago, simultaneously with the exacerbation of a known inflammatory bowel disease with hemorrhagic mucoid diarrhea and fever of up to 38.5°C. The patient's medical history included UC affecting the whole colon (pancolitis), diagnosed 5 months prior to the onset of the epidermal lesions, for which the patient was receiving treatment with oral prednisolone 10 mg/day and mesalazine granules. Blood tests showed severe anemia, leukocytosis, and increased inflammatory markers (C-reactive protein, erythrocyte sedimentation rate). Antinuclear antibodies (ANA), anti-double stranded DNA (anti-dsDNA) andtibodies, antineutrophil

  14. Azathioprine therapy selectively ablates human Vδ2+ T cells in Crohn’s disease

    Science.gov (United States)

    McCarthy, Neil E.; Hedin, Charlotte R.; Sanders, Theodore J.; Amon, Protima; Hoti, Inva; Ayada, Ibrahim; Baji, Vidya; Giles, Edward M.; Wildemann, Martha; Bashir, Zora; Whelan, Kevin; Sanderson, Ian; Lindsay, James O.; Stagg, Andrew J.

    2015-01-01

    Tumor-derived and bacterial phosphoantigens are recognized by unconventional lymphocytes that express a Vγ9Vδ2 T cell receptor (Vδ2 T cells) and mediate host protection against microbial infections and malignancies. Vδ2 T cells are absent in rodents but readily populate the human intestine, where their function is largely unknown. Here, we assessed Vδ2 T cell phenotype and function by flow cytometry in blood and intestinal tissue from Crohn’s disease patients (CD patients) and healthy controls. Blood from CD patients included an increased percentage of gut-tropic integrin β7–expressing Vδ2 T cells, while “Th1-committed” CD27-expressing Vδ2 T cells were selectively depleted. A corresponding population of CD27+ Vδ2 T cells was present in mucosal biopsies from CD patients and produced elevated levels of TNFα compared with controls. In colonic mucosa from CD patients, Vδ2 T cell production of TNFα was reduced by pharmacological blockade of retinoic acid receptor-α (RARα) signaling, indicating that dietary vitamin metabolites can influence Vδ2 T cell function in inflamed intestine. Vδ2 T cells were ablated in blood and tissue from CD patients receiving azathioprine (AZA) therapy, and posttreatment Vδ2 T cell recovery correlated with time since drug withdrawal and inversely correlated with patient age. These results indicate that human Vδ2 T cells exert proinflammatory effects in CD that are modified by dietary vitamin metabolites and ablated by AZA therapy, which may help resolve intestinal inflammation but could increase malignancy risk by impairing systemic tumor surveillance. PMID:26168223

  15. Azathioprine therapy selectively ablates human Vδ2⁺ T cells in Crohn's disease.

    Science.gov (United States)

    McCarthy, Neil E; Hedin, Charlotte R; Sanders, Theodore J; Amon, Protima; Hoti, Inva; Ayada, Ibrahim; Baji, Vidya; Giles, Edward M; Wildemann, Martha; Bashir, Zora; Whelan, Kevin; Sanderson, Ian; Lindsay, James O; Stagg, Andrew J

    2015-08-01

    Tumor-derived and bacterial phosphoantigens are recognized by unconventional lymphocytes that express a Vγ9Vδ2 T cell receptor (Vδ2 T cells) and mediate host protection against microbial infections and malignancies. Vδ2 T cells are absent in rodents but readily populate the human intestine, where their function is largely unknown. Here, we assessed Vδ2 T cell phenotype and function by flow cytometry in blood and intestinal tissue from Crohn's disease patients (CD patients) and healthy controls. Blood from CD patients included an increased percentage of gut-tropic integrin β7-expressing Vδ2 T cells, while "Th1-committed" CD27-expressing Vδ2 T cells were selectively depleted. A corresponding population of CD27+ Vδ2 T cells was present in mucosal biopsies from CD patients and produced elevated levels of TNFα compared with controls. In colonic mucosa from CD patients, Vδ2 T cell production of TNFα was reduced by pharmacological blockade of retinoic acid receptor-α (RARα) signaling, indicating that dietary vitamin metabolites can influence Vδ2 T cell function in inflamed intestine. Vδ2 T cells were ablated in blood and tissue from CD patients receiving azathioprine (AZA) therapy, and posttreatment Vδ2 T cell recovery correlated with time since drug withdrawal and inversely correlated with patient age. These results indicate that human Vδ2 T cells exert proinflammatory effects in CD that are modified by dietary vitamin metabolites and ablated by AZA therapy, which may help resolve intestinal inflammation but could increase malignancy risk by impairing systemic tumor surveillance. PMID:26168223

  16. Clinical effects of adalimumab treatment with concomitant azathioprine in Japanese Crohn’s disease patients

    Directory of Open Access Journals (Sweden)

    Kumi Ishida

    2013-01-01

    Full Text Available AIM: To assess adalimumab’s efficacy with concomitant azathioprine (AZA for induction and maintenance of clinical remission in Japanese Crohn’s disease (CD patients. METHODS: This retrospective, observational, single-center study enrolled 28 consecutive CD patients treated with adalimumab (ADA. Mean age and mean disease duration were 38.1 ± 11.8 years and 11.8 ± 10.1 years, respectively. The baseline mean Crohn’s disease activity index (CDAI and C-reactive protein were 177.8 ± 82.0 and 0.70 ± 0.83 mg/dL, respectively. Twelve of these patients also received a concomitant stable dose of AZA. ADA was subcutaneously administered: 160 mg at week 0, 80 mg at week 2, followed by 40 mg every other week. Clinical response and remission rates were assessed via CDAI and C-reactive protein for 24 wk. RESULTS: The mean CDAI at weeks 2, 4, 8, and 24 was 124.4, 120.2, 123.6, and 135.1, respectively. The CDAI was significantly decreased at weeks 2 and 4 with ADA and was significantly suppressed at 24 wk with ADA/AZA. Overall clinical remission rates at weeks 4 and 24 were 66.7% and 63.2%, respectively. Although no statistically significant difference in C-reactive protein was demonstrated, ADA with AZA resulted in a greater statistically significant improvement in CDAI at 24 wk, compared to ADA alone. CONCLUSION: Scheduled ADA with concomitant AZA may be more effective for clinical remission achievement at 24 wk in Japanese Crohn’s disease patients.

  17. Relevansen af nyere psykodynamisk teori for det klinisk musikterapeutiske arbejde med psykiatriske patienter med personlighedsforstyrrelser

    DEFF Research Database (Denmark)

    Hannibal, Niels

    2007-01-01

    Denne artikel beskriver et rationale for anvendelse af musik i en psykoterapeutisk kontekst. Det eksplicitte og implicitte forandringsniveau i psykoterapi med patienter med borderline-personlighedsforstyrrelse (BPF) diskuteres herpå med henvisning til to forskellige syn på terapeutisk forandring...

  18. Automation med pneumatiske servodrev - status og fremtid

    DEFF Research Database (Denmark)

    Sørensen, Paul Haase

    Der er råd for problemer med ulineariteter. Med de nyeste metoder kan der lineære driftsområde udvides. Men pneumatikkomponenter skal være af høj kvalitet, når positionering skal være nøjagtig....

  19. Erfaringer med mentorordninger i Herning Kommune

    DEFF Research Database (Denmark)

    Frederiksen, Lisbeth Angela Lunde

    2011-01-01

    , etablerede lærere i konstruktivt samspil med understøttelsen af nyuddannede lærere, og som yderligere kan bidrage til professions- og organisationsudvikling, der sikrer og udvikler pædagogisk praksis med høj faglig kvalitet. På baggrund af international forskning og en forundersøgelse i Herning Kommune om at...

  20. Digital kommunikation med den offentlige sektor

    DEFF Research Database (Denmark)

    Berger, Jesper; Andersen, Kim Normann

    2013-01-01

    i front med at besvare e-mails, mens hver fjerde e-mail til staten ikke blev besvaret. Langt værre ser det dog ud med digital post. Kun godt halvdelen af kommunerne svarer på digital post. Ingen af ministerierne svarer på digital post. Alle regionerne svarer på digital post. Efter en dag havde 80...

  1. Set med egne øjne

    DEFF Research Database (Denmark)

    Paaske, Karen Annette

    2013-01-01

    Et empirisk pilotprojekt om sygeplejen i primær sundhedstjeneste i et patientologisk perspektiv med fokus på medinddragelse. Det er et kvalitativt metodisk projekt, hvor dataindsamlingsmetoden er videooptagelser med videobrillekameraer. videoerne optaget i en hverdagspraksis og kan anskues som en...

  2. Stimulation med 0,3 mg rekombinant human thyrotropin øger effekten af 131 I-behandling hos patienter med atoksisk nodulaer struma. En prospektiv, randomiseret, dobbeltblindet undersøgelse--sekundaerpublikation

    DEFF Research Database (Denmark)

    Nielsen, Viveque Egsgaard; Bonnema, Steen Joop; Boel-Jørgensen, Henrik; Grupe, Peter; Hegedüs, Laszlo

    2006-01-01

    In a randomized, double-blind, placebo-controlled trial, 57 patients with nontoxic nodular goiter were stimulated with either 0.3 mg recombinant human thyrotropin (rhTSH) or placebo before radioactive iodine 131I therapy. After one year the goiter reduction had improved by 35% compared to...... conventional 131I therapy. The difference was most pronounced in patients with a large goiter. Adverse effects, including development of permanent hypothyroidism, were significantly more frequent in the rhTSH group. Patient satisfaction was high and uninfluenced by the use of rhTSH....

  3. Stimulation med 0,3 mg rekombinant human thyrotropin øger effekten af 131 I-behandling hos patienter med atoksisk nodulaer struma. En prospektiv, randomiseret, dobbeltblindet undersøgelse--sekundaerpublikation

    DEFF Research Database (Denmark)

    Nielsen, Viveque Egsgaard; Bonnema, Steen Joop; Jørgensen, Henrik Boel; Grupe, Peter; Hegedüs, Laszlo

    2006-01-01

    In a randomized, double-blind, placebo-controlled trial, 57 patients with nontoxic nodular goiter were stimulated with either 0.3 mg recombinant human thyrotropin (rhTSH) or placebo before radioactive iodine 131I therapy. After one year the goiter reduction had improved by 35% compared to...... conventional 131I therapy. The difference was most pronounced in patients with a large goiter. Adverse effects, including development of permanent hypothyroidism, were significantly more frequent in the rhTSH group. Patient satisfaction was high and uninfluenced by the use of rhTSH. Udgivelsesdato: 2006-Nov-20...

  4. Et reformert helsevesen – rett behandling – på rett sted – til rett tid?

    OpenAIRE

    Nærheim, Ådne

    2015-01-01

    Bakgrunn: Samhandlingsreformen ble innført 1. Januar 2012. Denne førte med seg flere forandringer, både i spesialisthelsetjenesten og kommunehelsetjenesten. Det kreves en ny kompetanse ute i kommunene da pasientene som er utskrivningsklare fra sykehus er i dårligere fatning nå enn tidligere. Hensikten med oppgaven var å se hvordan en kan opprettholde faglig forsvarlig sykepleie til syke og skrøpelige eldre for å unngå reinnleggelser. Metode: Oppgaven er utført som et litteraturstudie. For ...

  5. Plasma exchange combined with azathioprine in multiple sclerosis using serial gadolinium-enhanced MRI to monitor disease activity: a randomized single-masked cross-over pilot study

    DEFF Research Database (Denmark)

    Sørensen, P.S.; Wanscher, B; Szpirt, W; Jensen, C.V.; Ravnborg, M; Christiansen, P; Schreiber, K; Nordenbo, Annette Mosbæk

    1996-01-01

    We enrolled 11 patients with secondary progressive MS in a randomized single-masked cross-over study of plasma exchange (PE) in combination with azathioprine 2 mg/kg. PE was performed once a week for 4 weeks and thereafter every second week for 20 weeks (14 treatments). Eight patients completed the...... whole trial, and three patients discontinued the trial, two during the run-in period of azathioprine treatment and one at the introduction of PE. The primary efficacy variables were the number of gadolinium-enhancing lesions and the occurrence of new enhancing lesions on serial MRI performed every 3...

  6. Preclinical evaluation of azathioprine plus buthionine sulfoximine in the treatment of human hepatocarcinoma and colon carcinoma

    Directory of Open Access Journals (Sweden)

    Borja Hernández-Breijo

    2011-01-01

    Full Text Available AIM: To evaluate the efficacy and the safety of azathioprine (AZA and buthionine sulfoximine (BSO by localized application into HepG2 tumor in vivo. METHODS: Different hepatoma and colon carcinoma cell lines (HepG2, HuH7, Chang liver, LoVo, RKO, SW-48, SW-480 were grown in minimal essencial medium supplemented with 10% fetal bovine serum and 1% antibiotic/antimycotic solution and maintained in a humidified 37 °C incubator with 5% CO2. These cells were pretreated with BSO for 24 h and then with AZA for different times. We examined the effects of this combination on some proteins and on cellular death. We also studied the efficacy and the safety of AZA (6 mg/kg per day and BSO (90 mg/kg per day in HepG2 tumor growth in vivo using athymic mice. We measured safety by serological markers such as aminotransferases and creatine kinase. RESULTS: The in vitro studies revealed a new mechanism of action for the AZA plus BSO combination in the cancer cells compared with other thiopurines (6-mercaptopurine, 6-methylmercaptopurine, 6-thioguanine and 6-methylthioguanine in combination with BSO. The cytotoxic effect of AZA plus BSO in HepG2 cells resulted from necroptosis induction in a mitochondrial-dependent manner. From kinetic studies we suggest that glutathione (GSH depletion stimulates c-Jun amino-terminal kinase and Bax translocation in HepG2 cells with subsequent deregulation of mitochondria (cytochrome c release, loss of membrane potential, and proteolysis activation leading to loss of membrane integrity, release of lactate dehydrogenase and DNA degradation. Some of this biochemical and cellular changes could be reversed by N-acetylcysteine (a GSH replenisher. In vivo studies showed that HepG2 tumor growth was inhibited when AZA was combined with BSO. CONCLUSION: Our studies suggest that a combination of AZA plus BSO could be useful for localized treatment of hepatocellular carcinoma as in the currently used transarterial chemoembolization method.

  7. To års erfaringer med quinoa

    OpenAIRE

    Blume, Steffen

    2010-01-01

    De økologiske kornpriser i 2008 og 2009 gjorde det relevant at kigge på andre afgrøder, der har potentiale for at hæve bundlinjen. Sidste år påbegyndte vi derfor i samarbejde med Københavns Universitet et demonstrationsprojekt med afgrøden quinoa. Både i 2009 og 2010 blev afgrøden afprøvet på tre forskellige lokaliteter – lokaliteten på Bornholm blev dog skiftet ud med en lokalitet ved Ballerup.

  8. PubMed Medical Publications From Libya

    OpenAIRE

    O, Bakoush; AA, Al-Tubuly; N, Ashammakhi; Elkhammas EA

    2007-01-01

    Medical research and publications are the back-bone for advancing the medical field. We identified the Pubmed medical publications that are affiliated with Libya to shed some light on the contribution of this country’s medical community to the PubMed database. All publications affiliated with Libya in the PubMed were counted over a five year period ending December 2006. We also used the same method to obtain data on the PubMed medical publications from Tunisia, Morocco and Yemen. Tunisia had ...

  9. Ljudkudde med stereoåtergivning

    OpenAIRE

    Axing, Erik

    2010-01-01

    Detta examensarbete är genomfört i samarbete med Thorbjörn Birging. Birging arbetar med RFID[1] och är även VD för CombiQ på Science Park i Jönköping. Under lång tid har han velat skapa en produkt som hjälper människor med sömnproblem, depression, ångest och stress. Författarens roll som ingenjörsstudent blev att utveckla hans ide till en färdig produkt. Birging upptäckte efter att ha läst en artikel om sömnproblem att det finns studier som visar att det är enklare att somna med ett svagt lju...

  10. [CanMEDS 2015: better doctors?].

    Science.gov (United States)

    Borleffs, J C C; Mourits, M J E; Scheele, F

    2016-01-01

    Recently, the CanMEDS model, which forms the basis for competency-based learning in both undergraduate and postgraduate training, has been renewed by the introduction of CanMEDS 2015. The most prominent change is the emphasis on leadership skills, which is also reflected by the name change for the role of 'manager' to 'leader'. The addition of milestones provides clearly defined targets for learning and assessment, which facilitates the monitoring of the progression in competence. Furthermore, CanMEDS 2015 strongly focusses on the overall coherence of the separate competencies. CanMEDS, designed as a model that helps to train young doctors to become good doctors, also helps us - the trainers - to become better doctors ourselves. PMID:27438391

  11. LactMed: Drugs and Lactation Database

    Science.gov (United States)

    ... ADVANCED SEARCH Search Search Term Records with Include Synonyms and CAS Numbers in Search Browse for terms ... LactMed Advanced Search Search Term Records with Include Synonyms and CAS Numbers in Search Search in fields. ...

  12. Lydpuder med musik til psykiatriske patienter

    DEFF Research Database (Denmark)

    Bonde, Lars Ole

    2009-01-01

    Kort gennemgang af musikmedicinske og musikterapeutiske målsætninger og arbejdsmåder i psykiatrien i Danmark. Omtale af forsøg med musiklytning via "lyttepude" til psykiatriske patienter.......Kort gennemgang af musikmedicinske og musikterapeutiske målsætninger og arbejdsmåder i psykiatrien i Danmark. Omtale af forsøg med musiklytning via "lyttepude" til psykiatriske patienter....

  13. Ud med Freud, Marx og Lacan

    DEFF Research Database (Denmark)

    Clasen, Mathias

    2009-01-01

    Det er på høje tid, at humanister løsriver sig fra deres forældede teorier. Freud, Marx og Lacan skal erstattes med evolutionspsykologi, biologi og kognitionsvidenskab.......Det er på høje tid, at humanister løsriver sig fra deres forældede teorier. Freud, Marx og Lacan skal erstattes med evolutionspsykologi, biologi og kognitionsvidenskab....

  14. Tourism in the MED 11 countries

    OpenAIRE

    Lanquar, Robert

    2011-01-01

    For the last two decades, MED11 countries (Algeria, Egypt, Israel, Jordan, Lebanon, Libya, Morocco, Palestinian Autonomy, Syria, Tunisia and Turkey) have recorded the highest growth rate in inbound world tourism. In the same time, domestic tourism in these countries was growing very fast. MED 11 tourism performances have been astonishing in light of the security risks, natural disasters, oil prices rises and economic uncertainties of the region. The last financial crisis had no severe consequ...

  15. Effektelektronik - teknologi med energibesparelser og forbedret performance

    DEFF Research Database (Denmark)

    Blaabjerg, Frede

    2004-01-01

    Lige siden transistoren blev opfundet, har det altid været ønskeligt at kunne anvende en sådan til at styre store strømme/spændinger i elektriske systemer. Det er teknologisk også sket, først med tyristorer til styring af store effekter, men siden hen også med den bipolare transistor MOSFET, samt...

  16. Lack of evidence of a beneficial effect of azathioprine in dogs treated with prednisolone for idiopathic immune-mediated hemolytic anemia: a retrospective cohort study

    Directory of Open Access Journals (Sweden)

    Junius Greet

    2011-04-01

    Full Text Available Abstract Background Azathioprine is used as an immunosuppressant in canine immune-mediated hemolytic anemia (IMHA, but this potentially toxic and carcinogenic drug has not been proven to be beneficial. The aim of this study was to determine the difference in outcome and survival of dogs with idiopathic IMHA treated with a protocol that included azathioprine and prednisolone versus a protocol that included prednisolone alone. Results The study included 222 dogs with a hematocrit lower than 0.30 L/L and either a positive Coombs' test or spherocytosis and no evidence of diseases that could trigger IMHA. The clinical and laboratory data at the time of diagnosis and the response to therapy and survival were compared in dogs treated according to the prednisolone and azathioprine protocol (AP protocol; n = 149 and dogs treated according to the prednisolone protocol (P protocol; n = 73. At study entry, the two groups were comparable, except that thrombocyte counts were significantly lower and clinical signs had been present significantly longer in the AP protocol group. No significant difference in survival was found between the two groups: the 1-year survival was 64% (95% CI 54 - 77% in the P protocol group and 69% (95% CI 59-80% in the AP protocol group, respectively. Conclusions Azathioprine would appear not to be beneficial as standard treatment for all cases of IMHA; however, a blinded, randomized clinical trial is needed to establish whether outcome is different with the two treatment protocols.

  17. Plasma exchange combined with azathioprine in multiple sclerosis using serial gadolinium-enhanced MRI to monitor disease activity: a randomized single-masked cross-over pilot study

    DEFF Research Database (Denmark)

    Sørensen, P.S.; Wanscher, B; Szpirt, W; Jensen, C.V.; Ravnborg, M; Christiansen, P; Schreiber, K; Nordenbo, Annette Mosbæk

    1996-01-01

    whole trial, and three patients discontinued the trial, two during the run-in period of azathioprine treatment and one at the introduction of PE. The primary efficacy variables were the number of gadolinium-enhancing lesions and the occurrence of new enhancing lesions on serial MRI performed every 3...

  18. Danske børn med sprogforstyrrelser

    DEFF Research Database (Denmark)

    Sundahl Olsen, Lone

    2013-01-01

    Denne afhandling sætter fokus på en gruppe af danske børn med specifikke sproglige vanskeligheder (SLI). Fælles for disse børn er, at de har en normal IQ og ingen påviste neurologiske, følelsesmæssige, sociale eller fysiske vanskeligheder; men dette til trods tilegner disse børn sig ikke sproget......) 18 kontrolbørn med upåfaldende sprog i alderen 5;0 til 9;0 år matchet til børnene med SLI på alder. (3) 9 kontrolbørn med upåfaldende sprog i alderen 4;2 til 6;5 år matchet til børnene med SLI på score i en grammatisk forståelses test (TROG-2DK). Børnenes sproglige og kognitive færdigheder blev...... uoverensstemmelse mellem krav og ressourcer i forbindelse med håndteringen af opgaver, der stiller krav til kognition. De opgaver og test som i dag anvendes i klinisk- og forskningsmæssigpraksis stiller ofte forskellige krav til sproglige og generelle kognitive færdigheder, derfor bør denne viden om forekomsten af...

  19. Kan kunstige søtede produkter bidra til forebygging og behandling av overvekt?

    OpenAIRE

    2011-01-01

    THE ROLE OF ARTIFICIAL SWEETENERS IN PREVENTING OVERWEIGHT Overweight, obesity, type 2 diabetes and cardiovascular disease are demanding public health issues. Nutrition and physical activity are important contributors in preventing overweight. This article addresses artificial sweeteners, especially non-nutritive beverages, their role in our diet and significance in preventing the epidemic of overweight and obesity. The article is based on non-systematically searches on PubMed, Cochra...

  20. The MED-SUV Multidisciplinary Interoperability Infrastructure

    Science.gov (United States)

    Mazzetti, Paolo; D'Auria, Luca; Reitano, Danilo; Papeschi, Fabrizio; Roncella, Roberto; Puglisi, Giuseppe; Nativi, Stefano

    2016-04-01

    In accordance with the international Supersite initiative concept, the MED-SUV (MEDiterranean SUpersite Volcanoes) European project (http://med-suv.eu/) aims to enable long-term monitoring experiment in two relevant geologically active regions of Europe prone to natural hazards: Mt. Vesuvio/Campi Flegrei and Mt. Etna. This objective requires the integration of existing components, such as monitoring systems and data bases and novel sensors for the measurements of volcanic parameters. Moreover, MED-SUV is also a direct contribution to the Global Earth Observation System of Systems (GEOSS) as one the volcano Supersites recognized by the Group on Earth Observation (GEO). To achieve its goal, MED-SUV set up an advanced e-infrastructure allowing the discovery of and access to heterogeneous data for multidisciplinary applications, and the integration with external systems like GEOSS. The MED-SUV overall infrastructure is conceived as a three layer architecture with the lower layer (Data level) including the identified relevant data sources, the mid-tier (Supersite level) including components for mediation and harmonization , and the upper tier (Global level) composed of the systems that MED-SUV must serve, such as GEOSS and possibly other global/community systems. The Data level is mostly composed of existing data sources, such as space agencies satellite data archives, the UNAVCO system, the INGV-Rome data service. They share data according to different specifications for metadata, data and service interfaces, and cannot be changed. Thus, the only relevant MED-SUV activity at this level was the creation of a MED-SUV local repository based on Web Accessible Folder (WAF) technology, deployed in the INGV site in Catania, and hosting in-situ data and products collected and generated during the project. The Supersite level is at the core of the MED-SUV architecture, since it must mediate between the disparate data sources in the layer below, and provide a harmonized view to

  1. PubMed Medical Publications From Libya

    Directory of Open Access Journals (Sweden)

    Bakoush O

    2007-01-01

    Full Text Available Medical research and publications are the back-bone for advancing the medical field. We identified the PubMed medical publications that are affiliated with Libya to shed some light on the contribution of this country’s medical community to the PubMed database. All publications affiliated with Libya in the PubMed were counted over a five year period ending December 2006. We also used the same method to obtain data on the PubMed medical publications from Tunisia, Morocco and Yemen. Tunisia had the largest number of PubMed publications among the studied countries: 20.4 publications per million population per year and 7.2 publications per year per one billion US$ GDP. Libya had much fewer publications: 2.4 publications per million population per year and 0.4 publications per one billion US$ GDP. The citation frequency for Libyan published research was very low compared to Tunisian and Moroccan related research. Conclusion: This preliminary analysis shows that medical research output in Libya is about twenty times less than in other countries with similar backgrounds, and that it needs to be enhanced.

  2. A marvel of precision: MedAustron

    CERN Multimedia

    Anaïs Schaeffer

    2013-01-01

    MedAustron, which is currently being built in Austria, will be one of the most advanced centres for ion beam therapy and research in Europe. It is based on the same design as the Italian National Centre for Oncological Hadrontherapy (CNAO), which in turn is based on the CERN-led Proton Ion Medical Machine Study (PIMMS). MedAustron should welcome its first patient at the end of 2015.   Layout of the MedAustron accelerator complex.  With three ion-sources, a linac, a synchrotron and four irradiation rooms (see picture), MedAustron is a huge accelerator complex. Among other equipment, it comprises 300 magnets of 30 different types, all designed at CERN but produced at different sites: “We are working with five main suppliers from Europe and Russia,” explains Thomas Zickler, leader of the MedAustron magnet group. “All the magnets come to CERN to undergo a series of strict acceptance tests.” From the interfaces, to the electrical insulation, the co...

  3. Mindfulness i behandling av deprimerte og suicidale pasienter : Kan mindfulness påvirke ruminering?

    OpenAIRE

    2012-01-01

    Bakgrunn: Sammenhengen mellom ruminering og suicidalitet er godt dokumentert, ruminering beskrives som en kognitiv prosess, en del av den suicidale prosess, og er spesielt sentral hos de hvor tilbakevendende depresjon er en fremtredende risikofaktor for suicidalitet. Formålet med denne studien er å undersøke om det i forskningslitteraturen er støtte for hypotesen om at mindfulness kan redusere ruminering, og gjennom en slik reduksjon være et alternativ som ledd i behandlingen av suicidale pas...

  4. Medialt tibialt stress-syndrom. Riskfaktorer och konservativ behandling. - En litteraturstudie

    OpenAIRE

    Österman, Emilia

    2011-01-01

    Syftet med examensarbetet är att ta reda på vilka riskfaktorerna är för medialt tibialt stress-syndrom (MTSS) och vilka konservativa behandlingsmetoder som rekommenderas. MTSS är ett smärttillstånd på posteromediala sidan (bakre inre sidan) av tibia (skenbenet) förorsakat av överansträngning. Bland idrottare är underbenssmärta ett ständigt förkommande problem. Inom friidrottsföreningen IF Raseborg (examensarbetets uppdragsgivare) har idrottare årligen drabbats av smärta på posteromediala sida...

  5. Hydraulstyrning med konfiguration över Bluetooth

    OpenAIRE

    Olofsson, Petter; Utterström, Jimmy

    2015-01-01

    Denna rapport omfattar konstruktionen av ett fristående drivkort med tillhörande mobilapplikation för styrning och konfiguration av ett hydraulsystem. Projektets syfte var att på beställaren Bosch Rexroth ABs begäran undersöka om pump control module (PCM) - en del ur det existerande Spider 3 styrsystemet - kunde användas som en fristående modul. Hårdvara med en Bluetoothmodul skapades och kopplades mot PCM för att möjliggöra kommunikation via Bluetooth. En mobilapplikation utvecklades i Andro...

  6. Forandringslæring med autismediagnoser?

    DEFF Research Database (Denmark)

    Gustafson, Kari Ingrid; Mørck, Line Lerche

    2013-01-01

    Rasmus’ ændringer i læring, selvforståelse og tilhørsforhold perspektiveres med andre ASF-diagnostiseredes læring udforsket bl.a. gennem gruppeinterviews i regi af Asperger-foreningen. Artiklen byder således på et alternativ i form af at forstå forandringslæring som overskridende læring, med langt større...... hvor fx Asperger-foreningen, lærere og skolebørns- og unges-fællesskaber, samt forældrene er vigtige aktører i overskridelsen af marginalisering....

  7. Ti år med formidlingspligt

    DEFF Research Database (Denmark)

    Meyer, Gitte

    2014-01-01

    Jubilæet blev markeret ved et symposium - men hvor var journalisterne, og hvor var forskerne? For få uger siden lagde TV 2 hus til et symposium om videnskab, formidling, journalistik og spin. Danske Videnskabsjournalister og Akademiet for de Tekniske Videnskaber tog med arrangementet et behjertet...... initiativ. De ville gøre status efter ti år med lovfæstet formidlingspligt på universiteterne. Samtidig lagde de op til et kritisk blik på universitetsverdenens kommunikationsafdelinger...

  8. Effektivt ingeniørarbeid med BIM

    OpenAIRE

    Haugsand, Magnus

    2010-01-01

    Byggebransjen har etter innføringen av datamaskiner hatt liten vekst i lønnsomhet sammenlignet med andre bransjer. BIM — bygningsinformasjonsmodellering — er en teknologi som kan fornye hele bransjen. Men selv om BIM har blitt innført, gjennomføres prosjekteringen fortsatt med tradisjonelle metoder. Denne masteroppgaven ønsker å undersøke hvordan informasjonen i en bygningsinformasjonsmodell kan utnyttes mer effektivt, og hvordan arbeidsmetodene må utformes for å oppnå dette. For å definere h...

  9. Azathioprine desensitizes liver cancer cells to insulin-like growth factor 1 and causes apoptosis when it is combined with bafilomycin A1

    International Nuclear Information System (INIS)

    Hepatoblastoma is a primary liver cancer that affects children, due to the sensitivity of this tumor to insulin-like growth factor 1 (IGF-1). In this paper we show that azathioprine (AZA) is capable of inhibiting IGF1-mediated signaling cascade in HepG2 cells. The efficiency of AZA on inhibition of proliferation differs in the evaluated cell lines as follows: HepG2 (an experimental model of hepatoblastoma) > Hep3B (derived from a hepatocellular carcinoma) > HuH6 (derived from a hepatoblastoma) ≫ HuH7 (derived from a hepatocellular carcinoma) = Chang Liver cells (a non-malignant cellular model). The effect of AZA in HepG2 cells has been proven to derive from activation of Ras/ERK/TSC2, leading to activation of mTOR/p70S6K in a sustained manner. p70S6K phosphorylates IRS-1 in serine 307 which leads to the uncoupling between IRS-1 and p85 (the regulatory subunit of PI3K) and therefore causing the lack of response of HepG2 to IGF-1. As a consequence, proliferation induced by IGF-1 is inhibited by AZA and autophagy increases leading to senescence of HepG2 cells. Our results suggest that AZA induces the autophagic process in HepG2 activating senescence, and driving to deceleration of cell cycle but not to apoptosis. However, when simultaneous to AZA treatment the autophagy was inhibited by bafilomycin A1 and the degradation of regulatory proteins of cell cycle (e.g. Rb, E2F, and cyclin D1) provoked apoptosis. In conclusion, AZA induces resistance in hepatoblastoma cells to IGF-1, which leads to autophagy activation, and causes apoptosis when it is combined with bafilomycin A1. We are presenting here a novel mechanism of action of azathioprine, which could be useful in treatment of IGF-1 dependent tumors, especially in its combination with other drugs. - Highlights: • Azathioprine activated Ras/ERK/TSC-2/mTOR/p70S6K signaling pathway in HepG2 cells. • Azathioprine inhibited IGF-1-mediated signaling cascade. • Azathioprine induced autophagy leading to cell cycle

  10. Azathioprine desensitizes liver cancer cells to insulin-like growth factor 1 and causes apoptosis when it is combined with bafilomycin A1

    Energy Technology Data Exchange (ETDEWEB)

    Hernández-Breijo, Borja [Departamento de Biología de Sistemas, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Universidad de Alcalá, 28871 Alcalá de Henares (Spain); Monserrat, Jorge [Departamento de Medicina y Especialidades Médicas, Universidad de Alcalá, 28871 Alcalá de Henares (Spain); Román, Irene D. [Departamento de Biología de Sistemas, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Universidad de Alcalá, 28871 Alcalá de Henares (Spain); González-Rodríguez, Águeda [Departamento de Biomedicina y Biotecnología, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Universidad de Alcalá, 28871 Alcalá de Henares (Spain); Fernández-Moreno, M. Dolores [Departamento de Biología de Sistemas, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Universidad de Alcalá, 28871 Alcalá de Henares (Spain); and others

    2013-11-01

    Hepatoblastoma is a primary liver cancer that affects children, due to the sensitivity of this tumor to insulin-like growth factor 1 (IGF-1). In this paper we show that azathioprine (AZA) is capable of inhibiting IGF1-mediated signaling cascade in HepG2 cells. The efficiency of AZA on inhibition of proliferation differs in the evaluated cell lines as follows: HepG2 (an experimental model of hepatoblastoma) > Hep3B (derived from a hepatocellular carcinoma) > HuH6 (derived from a hepatoblastoma) ≫ HuH7 (derived from a hepatocellular carcinoma) = Chang Liver cells (a non-malignant cellular model). The effect of AZA in HepG2 cells has been proven to derive from activation of Ras/ERK/TSC2, leading to activation of mTOR/p70S6K in a sustained manner. p70S6K phosphorylates IRS-1 in serine 307 which leads to the uncoupling between IRS-1 and p85 (the regulatory subunit of PI3K) and therefore causing the lack of response of HepG2 to IGF-1. As a consequence, proliferation induced by IGF-1 is inhibited by AZA and autophagy increases leading to senescence of HepG2 cells. Our results suggest that AZA induces the autophagic process in HepG2 activating senescence, and driving to deceleration of cell cycle but not to apoptosis. However, when simultaneous to AZA treatment the autophagy was inhibited by bafilomycin A1 and the degradation of regulatory proteins of cell cycle (e.g. Rb, E2F, and cyclin D1) provoked apoptosis. In conclusion, AZA induces resistance in hepatoblastoma cells to IGF-1, which leads to autophagy activation, and causes apoptosis when it is combined with bafilomycin A1. We are presenting here a novel mechanism of action of azathioprine, which could be useful in treatment of IGF-1 dependent tumors, especially in its combination with other drugs. - Highlights: • Azathioprine activated Ras/ERK/TSC-2/mTOR/p70S6K signaling pathway in HepG2 cells. • Azathioprine inhibited IGF-1-mediated signaling cascade. • Azathioprine induced autophagy leading to cell cycle

  11. Feltforsøk med vibreringsfri betong

    OpenAIRE

    Kompen, Reidar

    1999-01-01

    Den 1. februar 1999 ble de to 18,5 lange kulvertveggene i Kvennabakkundergangen, Rv 651 i Volda i Møre og Romsdal, utstøpt med vibreringsfri betong som et feltforsøk. Betongen inneholdt tilsetningsstoffet Sika Viscocrete 3.

  12. Elever med adfærdsvanskeligheder

    DEFF Research Database (Denmark)

    Nissen, Poul

    2001-01-01

    Artikel i særnummer om folkeskolens urolige elever, hvor der redegøres for den viden der aktuelt er i Danmark på området samt vanskelighederne med at skelne mellem de elever i skolen, der reagerer "sundt" på omgivelsernes pres og de elever som har alvorligere problemer. De kan se ens ud på...

  13. Digital kommunikation med den offentlige sektor

    DEFF Research Database (Denmark)

    Berger, Jesper Bull; Andersen, Kim Normann

    Udgangspunktet for vores undersøgelse om digital kommunikation med det offentlige er et positivt ståsted for så vidt angår den fremadrettede anvendelse af digitalisering. Vi deler således den normative målsætning udtrykt bl.a. i Regeringens, KLs og Danske Regioners 2015 - digitaliseringsstrategi...

  14. MedAustron - Austrian Hadron Therapy Centre

    CERN Document Server

    Benedikt, M; 10.1109/NSSMIC.2008.4774090

    2009-01-01

    MedAustron is a synchrotron based accelerator facility for cancer treatment with proton and carbon ion beams. In addition to the clinical application, the accelerator will also provide beams for non-clinical research, in the fields of medical radiation physics, radiation biology and experimental physics.

  15. Hvordan opplever de seilende på kontrakt med Statoil kontakten med Statoil Marin?

    OpenAIRE

    Hellesø, Bjørn Kristian Torsvik; Rasmussen, Niclas Elde; Hersvik, Robert Bordvik

    2012-01-01

    Statoil Marin ble opprettet i 1997, og er en viktig aktør i å hindre sammenstøt mellom fartøy og Statoils installasjoner. De har hatt en positiv utvikling fra tolv sammenstøt i 2000, til ingen i 2009 og 2010. Vi spør oss i denne oppgaven: hvordan opplever de seilende på kontrakt med Statoil kontakten med Statoil Marin? For å belyse dette ble det foretatt et besøk hos Statoil Marin på Sandsli i Bergen. Her ble det gitt en introduksjon i hva Statoil Marin arbeider med, og hvordan...

  16. MED-SUV Data Life Cycle

    Science.gov (United States)

    Sangianantoni, Agata; Puglisi, Giuseppe; Spampinato, Letizia; Tulino, Sabrina

    2015-04-01

    The MED-SUV project aims to implement a digital e-infrastructure for data access in order to promote the monitoring and study of key volcanic regions prone to volcanic hazards, and thus improve hazard assessment, according to the rationale of Supersite GEO initiative to Vesuvius- Campi Flegrei and Mt Etna, currently identified as Permanent Supersites. The present study focuses on the life cycle of MED-SUV data generated in the first period of the project and highlights the managing approach, as well as the crucial steps to be implemented for ensuring that data will be properly and ethically managed and can be used and accessed from both MED-SUV and the external community. The process is conceived outlining how research data being handled as the project progresses, describing what data are collected, processed or generated and how these data are going to be shared and made available through Open Access. Data cycle begins with their generation and ends with the deposit in the digital infrastructure, its key series of stages through which MED-SUV data passes are Collection, Data citation, Categorization of data, Approval procedure, Registration of datasets, Application of licensing models, and PID assignment. This involves a combination of procedures and practices taking into account the scientific core mission and the priorities of the project as well as the potential legal issues related to the management and protection of the Intellectual Property. We believe that the implementation of this process constitutes a significant encouragement in MED-SUV data sharing and as a consequence a better understanding on the volcanic processes, hazard assessment and a better integration with other Supersites projects.

  17. Acute Pancreatitis Induced by Azathioprine and 6-mercaptopurine Proven by Single and Low Dose Challenge Testing in a Child with Crohn Disease.

    Science.gov (United States)

    Yi, Geum-Chae-Won; Yoon, Ka-Hyun; Hwang, Jin-Bok

    2012-12-01

    We report here a case of drug-induced acute pancreatitis proved by elimination and single, low dose challenge test in a child with Crohn disease. A 14-year-old boy with moderate/severe Crohn disease was admitted due to high fever and severe epigastric pain during administration of mesalazine and azathioprine. Blood test and abdominal ultrasonography revealed acute pancreatitis. After discontinuance of the medication and supportive care, the symptoms and laboratory findings improved. A single, low dose challenge test was done to confirm the relationship of the adverse drug reaction and acute pancreatitis, and to discriminate the responsible drug. Azathioprine and 6-mercaptopurine showed positive responses, and mesalazine showed a negative response. We introduce the method of single, low dose challenge test and its interpretation for drug-induced pancreatitis. PMID:24010098

  18. Disseminated cutaneous herpes simplex infection in a patient with Crohn's disease under azathioprine and steroids: First case report and literature review.

    Science.gov (United States)

    Santos-Antunes, João; Abreu, Cândida; Magro, Fernando; Coelho, Rosa; Vilas-Boas, Filipe; Andrade, Patrícia; Lopes, Susana; Macedo, Guilherme

    2014-04-01

    Immunosuppressive treatments used in the management of Inflammatory Bowel Disease, namely steroids, thiopurines and anti-TNF drugs, raise the risk of acquiring opportunistic infections. However, most of these infections are mild and self-limited, not requiring specific therapy or suspension of the immunosuppressors. We report a case of disseminated cutaneous herpes simplex infection in a patient with Crohn's disease under steroids and azathioprine. PMID:24257435

  19. MED-SUV final strategic issues

    Science.gov (United States)

    Spampinato, Letizia; Puglisi, Giuseppe; Sangianantoni, Agata

    2016-04-01

    Aside the scientific, technical and financial aspects managed by the "Project Management" Work Package (WP1), the great challenge and more time consuming task of this WP has surely been the definition and application of some strategic guidelines crucial to trace the project right path to its final success and for the project outcome sustainability after month 36. In particular, given that one of the main objectives of MED-SUV is that to be compliant with the GEO initiative, particularly concerning the data sharing, great efforts have been made by WP1 at first to define the MED-SUV Data Policy Guidelines, and currently to make it suitable for the EU Supersites. At present, WP1 is also dealing with the exploitation of the achieved foreground among the project's participant and to define a Memorandum of Understanding to sustain the monitoring systems and e-infrastructure developed in the project framework. Whilst the Data Policy guidelines document was implemented in the first year of MED-SUV, WP1 is now focused on the last deliverable 'Strategic and Legal deliverables', which includes the remaining issues. To the aim, WP1 has strategically separated the Exploitation of Foreground document preparation from the Memorandum of Understanding definition. The Exploitation of Foreground process has regarded the identification of Foreground, the exploitable results, the purpose of such Foreground, the collection of information from either the scientific community of MED-SUV or industrial participants; to this aim WP1 circulated an ad hoc questionnaire to put together information on (the) every kind of MED-SUV outcome, on their owners, on the kind of ownership (single/joint), on the outcome exploitation, and on proposals for its sustainability. While the first information will allow us to prepare the final Exploitation Agreement among the project's participant, the information on the exploitation of the outcome and likely sustainability proposals will contribute to the

  20. Hydro-Quebec MED (Diametric Expansion Measurement)

    International Nuclear Information System (INIS)

    This paper describes a method for measuring the diametral expansion of the pressure tubes at Gentilly-2 nuclear generating station. The aim is to describe the solutions, the calibration tools, and the analytical methods developed for the project. To measure the diametral expansion of the pressure tubes, Hydro-Quebec modified the SLARette device and integrated a new module called MED. The measurement system is made up of three parts: 1. An inspection head, the MED (Hydro-Quebec) module, which has five ultrasonic probes that determine the distance between the inspections head and pressure tube. Measurements are always done under water and they are used to determine the diameter and thickness of the pressure tubes. 2. Tomoscan III acquisition system by R/D Tech to scan the five probes and save the data in an A-scan file. 3. An Analytical software: LogaMED (Hydro-Quebec). The advanced delivery machine (ADM) equipped with a SLARette device is primarily an axial inspection system. The ADM and SLARette device are not capable of performing an axial/rotational inspection and have no centering system. However, measuring the diametral creep requires spiral scanning and a centered tool. A method that would allow the walls of the tubes to be measured in an uncentered way and to recalculate the diameters as if the device were centered has been designed. An automatic analytical software program (LogaMED) was designed to perform the calculation. LogaMED reads A-scan file data and provides the user with information on diameter and thickness. Two methods can be used to determine the diameter. The first consists in moving lengthwise through the tube. Several passes can be done at different angles and the results compiled in LogaMED. The second method is used to measure the diameter at every angle with an angular displacement (3600 rotation). Two of the main problems that had to be resolved were the calibration of the calculation parameters and the determination of measurement

  1. Mobil tidsrapportering med tidstjänster

    OpenAIRE

    Gullberg, Fredrik

    2012-01-01

    Syftet med det här examensarbetet var att underlätta tidsrapporteringsprocessen för näringslivet genom att undersöka möjligheten till ett mobilt verktyg, mer specikt en iPhone-applikation, som använder sig av platstjänster för att känna igen vilken kund användaren jobbar med för tillfället. Metoden gick ut på att undersöka vilka tekniker som finns tillgängliga, skapa enskilda konceptapplikationer för att testa dem och slutligen skapa en större applikation som utnyttjar teknikerna. Slutsatsen ...

  2. Poetisk sortsyn med lys for enden

    DEFF Research Database (Denmark)

    Larsen, Peter Stein

    2015-01-01

    Ursula Andkjær Olsens digtsamling " Udgående fartøj" indledes med den følgende prægnante passage, der kan læses i sin helhed som " ugens digt" her på siden: " jeg har brugt tid på at tyde/ sprede dumpe fornemmelser / fra mit fjerne indre (...)......Ursula Andkjær Olsens digtsamling " Udgående fartøj" indledes med den følgende prægnante passage, der kan læses i sin helhed som " ugens digt" her på siden: " jeg har brugt tid på at tyde/ sprede dumpe fornemmelser / fra mit fjerne indre (...)...

  3. ARM i inbyggt system : med prototyp

    OpenAIRE

    Abdulhadi, Sami

    2009-01-01

    Inbyggda system blir allt vanligare i dagens samhälle. De inbyggda systemen finns i nästan allt nuförtiden, från diverse fordon till leksaker för barn. Dagens teknik innebär bland annat att gårdagens lösningar kan realiseras på en bråkdel av den tidigare ytan. Allt mer blir ytmonterat med mindre och mer komplexa kretsar. Detta är inte alltid till utvecklarnas fördel då montering av prototypkort blir en svår och/eller dyr process. Målet är att ta fram ett inbyggt system med en ARM-processor. S...

  4. RFID-avläsning med mobiltelefon

    OpenAIRE

    Svensson, Torbjörn

    2007-01-01

    MobileReader är en mobil RFID (Radio Frequency Identification) applikation. Syftet med denna applikation är att skapa en RFID-läsare som skall gå att bära med sig ute på fältet. I första hand kommer läsaren att kunna läsa passiva RFID-taggar på Lågfrekvens-bandet (LF) samt att vara anpassad för nyare mobiltelefoner av tillverkaren Sony Ericsson. Detta examensarbete resulterade i ett program avsett för en Atmel ATmega16 mikroprocessor. Mikroprocessorn tar emot data från en befintlig LF-läsare ...

  5. Fenologi hos alm visar samband med almsjuka

    OpenAIRE

    Black Samuelsson, Sanna; Ghelardini, Luisa

    2008-01-01

    • Almar angrips alltmer av almsjukan. Antalet insjuknade och döda träd har ökat påfallande senaste åren. Ett komplext samspel mellan trädet, svampen (Ophiostoma novo-ulmi), almsplintborren (Scolytus spp., insekten som överför svampen till trädet) och den omgivande miljön, avgör om trädet blir smittat eller inte. • Träd med tidig knoppsprickning på våren och sydligt ursprung löper lägst risk att bli smittade. • Hos träd med tidig knoppsprickning har vårveden hunnit övergå i sen ved, vars träng...

  6. Effects of carbon tetrachloride and azathioprine on diethylnitrosamine and N-2-fluorenylacetamide-induced hyperplastic liver nodule and hepatocellular carcinoma

    Directory of Open Access Journals (Sweden)

    Sakata,Tatsuro

    1984-12-01

    Full Text Available Effects of carbon tetrachloride (CCl4 and azathioprine (AZP on the evolution of hyperplastic liver nodules and foci and hepatocellular carcinoma (HCC were tested in short- and long-term in vivo experiments. In diethylnitrosamine (DEN-treated rats, which were fed a N-2-fluorenylacetamide (FAA-containing diet and additionally treated with repeated CCl4 injections, gamma-glutamyl transpeptidase (gamma-GTP-positive hyperplastic nodules were markedly developed in the 8th week of the experiment. However, their number and area in liver sections were remarkably small in DEN-treated rats fed a diet containing both FAA and AZP. Increased area of gamma-GTP-positive foci was also observed in the 12th week in DEN-injected rats fed a choline-devoid died alone or treated with repeated doses of CCl4 alone. Hepatocellular carcinoma in DEN-injected rats treated with both FAA and CCl4 was first detected in the 21st week, and the incidence up to the 36th week was very high. However, no hepatocellular carcinoma developed in DEN-injected rats treated with both FAA and AZP. The increased activity of liver aniline hydroxylase observed 12 h after the administration of FAA, AZP or DEN alone was not observed when AZP was administered simultaneously with FAA to DEN-injected rats. The mechanisms of the effects of CCl4 and AZP on hepatocarcinogenesis are discussed with special reference to drug interaction.

  7. Primary EBV-positive Hodgkin's lymphoma of the CNS under azathioprine treatment. Case report and review of the literature

    International Nuclear Information System (INIS)

    Retrospective and prospective cohort studies suggest that central nervous system involvement occurs in approximately 0.5 % of patients with advanced Hodgkin's lymphoma. The isolated primary intracranial manifestation of Hodgkin's lymphoma is an extremely rare finding, with few cases reported in the literature. Little is known about the optimal treatment and prognosis of these tumors. Here, we present a case report with a review of the literature. A 47-year-old Caucasian man with persistent frontal headache and unspecific vertigo for half a month was diagnosed with nodular space-occupying lesions in the cerebellum. His medical history included multiple sclerosis, which was treated for 20 years with the immunosuppressive drug azathioprine. Further staging revealed no additional lesions suspected of being malignant. The patient underwent total tumor resection. Immunohistopathological examination showed Epstein-Barr virus-associated classic Hodgkin's lymphoma. Diagnostic bone marrow punction excluded lymphoma involvement of the bone marrow. The patient had no B symptoms. Consequently, the patient was classified as having stage IEA disease according to the Modified Ann Arbor Classification of Hodgkin Lymphoma and received systemic chemotherapy followed by radiation therapy for the former cerebellar tumor region. He was in complete clinical remission at the last follow-up 9 months after the initial diagnosis. This case report and literature review suggest that multimodal treatment leads to a remarkable clinical outcome in Hodgkin's lymphoma with intracranial involvement. (orig.)

  8. Inklusion i folkeskolen med musik og musikterapi

    DEFF Research Database (Denmark)

    Lindvang, Charlotte

    2014-01-01

    I denne artikel sættes der fokus på nogle af de problemer og udfordringer som knytter sig til kravet om inklusion af børn med særlige behov i den almindelige folkeskole, og der argumenteres for at styrke anvendelsen af musik i forhold til at skabe fællesskab og optimere børnenes opmærksomhed og i...

  9. MEDSEBOJNI VPLIVI MED SISTEMI DVOSISTEMSKEGA PRENOSNEGA VODA

    OpenAIRE

    Lampret, Ernest

    2015-01-01

    Nesimetrije, ki se pojavijo v elektroenergetskem sistemu, lahko imajo izvor v nesimetričnem odjemu električne energije ali pa v samih elementih prenosnega sistema (transformatorjih, prenosnih vodih ....). Prav pri slednjih so napetostne in tokovne nesimetrije posledica elektromagnetne sklopljenosti med vodnik in sistemi, ki so asimetrično razporejeni v glavah stebrov. Izpeljani izrazi za izračun parametrov voda so bili uporabljeni kot vhodni podatki v modelu dvosistemskega prenosnega voda...

  10. Sydkorea: Teknologiske tigerspring med globale udfordringer

    DEFF Research Database (Denmark)

    Brynskov, Martin

    2010-01-01

    Sydkorea har gennemgået en utrolig udvikling fra u-land til førende i-land i løbet af få årtier. Helt centralt står den teknologiske eksport af elektronik, biler og skibsbyggeri i verdenseliten. Men på trods af de mange succeser er der også udfordringer. Denne analyse viser – med aktuelle eksempl...

  11. Technical development of PubMed Interact: an improved interface for MEDLINE/PubMed searches

    Directory of Open Access Journals (Sweden)

    Fontelo Paul

    2006-11-01

    Full Text Available Abstract Background The project aims to create an alternative search interface for MEDLINE/PubMed that may provide assistance to the novice user and added convenience to the advanced user. An earlier version of the project was the 'Slider Interface for MEDLINE/PubMed searches' (SLIM which provided JavaScript slider bars to control search parameters. In this new version, recent developments in Web-based technologies were implemented. These changes may prove to be even more valuable in enhancing user interactivity through client-side manipulation and management of results. Results PubMed Interact is a Web-based MEDLINE/PubMed search application built with HTML, JavaScript and PHP. It is implemented on a Windows Server 2003 with Apache 2.0.52, PHP 4.4.1 and MySQL 4.1.18. PHP scripts provide the backend engine that connects with E-Utilities and parses XML files. JavaScript manages client-side functionalities and converts Web pages into interactive platforms using dynamic HTML (DHTML, Document Object Model (DOM tree manipulation and Ajax methods. With PubMed Interact, users can limit searches with JavaScript slider bars, preview result counts, delete citations from the list, display and add related articles and create relevance lists. Many interactive features occur at client-side, which allow instant feedback without reloading or refreshing the page resulting in a more efficient user experience. Conclusion PubMed Interact is a highly interactive Web-based search application for MEDLINE/PubMed that explores recent trends in Web technologies like DOM tree manipulation and Ajax. It may become a valuable technical development for online medical search applications.

  12. Logopeders samtal med närstående till en person med afasi : En samtalsanalys

    OpenAIRE

    Jansson, Lisa; Höglund, Emelie

    2015-01-01

    I institutionella samtal såsom närståendesamtal mellan en logoped, en närstående till en person med afasi och personen med afasi råder en asymmetri gällande maktförhållandet. Asymmetrin som uppstår i det institutionella samtalet kan innebära att samtalsdeltagaren med minst makt upplever ansiktshot. I samtal ses förståelse som en dynamisk process och när förståelsen innebär ett problem i konversationen störs den pågående aktiviteten. Mottagaren kan lösa problemet som uppstått genom att ge tala...

  13. Tur-samspil i musikterapi med børn med svære kommunikationsvanskeligheder

    DEFF Research Database (Denmark)

    Holck, Ulla

    2006-01-01

    Tur-samspil udgør en vigtig grundsten i den tidlige sociale og kommunikative udvikling, og optræder ofte i musikterapeutiske samspil med kommunikationssvage børn. Artiklen præsenterer relevante begreber fra faglitteraturen om tur-samspil i voksendialoger (de såkaldte Konversationsanalyser), som kan...... bruges til at analysere musikterapeutiske samspil. Da karakteren af tur-organisering afhænger af udviklingsalder, sammenholdes de beskrevne cues med forskning i tidlige forældre-barn samspil. Fagbegreberne belyses gennem en række musikterapeutiske case-vignetter fra forfatterens ph.d. afhandling...... henvender sig dog bredt til alle med interesse for tidlige kommunikationsformer, også hos betydeligt ældre klientgrupper....

  14. Vrzeli med medicino in socialnim delom

    OpenAIRE

    Kvaternik, Ines; Grebenc, Vera

    2014-01-01

    Članek prikazuje diskurzivne vrzeli med medicino in socialnim delomter prinaša za socialno delo bolj uporabne poglede na vsakdanje potrebe ljudi, ki so v medicini oz. v psihiatriji prepoznani kot ljudje, ki imajo "dvojne diagnoze". Z njim hočemo opozoriti na pomen in vlogo socialnih služb pri obravnavi uporabnikov, ki imajo "kompleksne" potrebe. Če hočemo razumeti, kakšna so naloge socialnega dela na področju "dvojnih diagnoz", moramo prevetriti vlogo socialnega dela v zdravstvu in reflektira...

  15. : at vokse op med en global mediegigant

    OpenAIRE

    Drotner, Kirsten

    2003-01-01

    Alle har et forhold til Disneys figurer, der findes i ethvert dansk børneværelse - i blade, på film, som musik og som krammedyr, på tøj og skoletasker. Alligevel findes der kun ganske lidt samlet viden om, hvad verdens største mediegigant betyder for brugerne - børnene selv. Gennem analyse af interview med 48 børn og deres forældre belyses den indflydelse, Disneys univers har på danske børns identitet i spændingsfeltet mellem det globale og det lokale.

  16. Effektiv sikkerhetstesting av webapplikasjoner med rikt innhold

    OpenAIRE

    Eriksen, Ole Jacob Syrdahl

    2008-01-01

    I nyere webapplikasjoner er brukerinnhold, interaktivitet og rask responstid blitt viktig. Kravene medfører nye kommunikasjonsmodeller og applikasjonslogikk på klientsiden. Utviklingen har ført til at tradisjonelle teknikker for sikkerhetstesting ikke lenger gir et helhetlig bilde av de sårbarheter webapplikasjonen er utsatt for. Det blir i oppgaven sett på metoder for å effektivisere sårbarhetsanalysen av web-applikasjoner med rik klientkode. Som et ledd i å effektivisere sårbarhetsanalyse...

  17. Lineær programmering med Excel

    DEFF Research Database (Denmark)

    Lynggaard, Peter

    Publikationen giver en introduktion til faget "Lineær programmering". Formulering og løsning bygger på, at modellerne opstilles og løses i et Excel-regneark. Fremgangsmåden er forklaret trin for trin, således at hæftet kan bruges som selvstudiemateriale. Indholdsfortegnelse Generelt om styring og...... planlægning Lineær programmering Excel solveren Fortolkning af udskrifter Degeneration Excel tips Opgaver med løsninger...

  18. Metodeudvikling af hjælp til familier med børn med handicap

    DEFF Research Database (Denmark)

    Henriksen, Kirsten; Nørregård, Birgitte

    2000-01-01

    Et undersøgelses- og metodeudviklingsprojekt i relation til forældre til børn med handicap, der passer deres barn i hjemmet. Projektet var finansieret af satspuljemidler. projektet bestod af en række delprojekter, hvis resultater samt anbefalinger til Socialministeriet er samlet i denne evaluerin......Et undersøgelses- og metodeudviklingsprojekt i relation til forældre til børn med handicap, der passer deres barn i hjemmet. Projektet var finansieret af satspuljemidler. projektet bestod af en række delprojekter, hvis resultater samt anbefalinger til Socialministeriet er samlet i denne...

  19. Determination of 6-thioguanine and 6-methylmercaptopurine metabolites in renal transplantation recipients and patients with glomerulonephritis treated with azathioprine.

    Science.gov (United States)

    Chrzanowska, M; Krzymański, M

    1999-04-01

    The metabolism of azathioprine (AZA) was studied by monitoring the concentrations of red blood cell (RBC) 6-thioguanine nucleotides (6-TGN) and of 6-methylmercaptopurine metabolites (6-mMP) in 27 renal transplantation recipients and in 10 patient subjects with glomerulonephritis (GN). Concentrations of 6-TGNs and 6-mMP metabolites were measured using high-performance liquid chromatography (HPLC). Six patients from the group of renal transplantation recipients were also administered allopurinol. Median values of RBC 6-TGN and of 6-mMP metabolites concentrations in 21 renal transplantation recipients (without allopurinol) were 122 pmol/8x10(8) RBCs (range, allopurinol were significantly higher, despite AZA dose reduction, compared with the group without allopurinol and were equal to 363 and 122 pmol/8x10(8) RBC, p < 0.004, respectively. No significant differences were found between the concentrations of 6-mMP metabolites in either group. In the group of renal transplantation recipients, a significant correlation between white blood cell (WBC) count and 6-TGN concentration was established (r(s) = -0.59, p < 0.005). In the group of GN patients, the median values of 6-TGN and of 6-mMP metabolites concentrations were 108 pmol/8x10(8) RBCs (range, 0-297) and 420 pmol/8x10(8) RBC (range, 0-1440), respectively. There were no significant correlations between either the WBC count and 6-TGN concentrations or between 6-TGN concentrations and 6-mMP metabolites. We expect the results of our study to provide indications for better individualization of AZA therapy. PMID:10217345

  20. Læreren og spesialpedagogens møte med begavede elever og begavede elever med lærevansker

    OpenAIRE

    Nordlund, Lene

    2015-01-01

    Oppgavens tema er begavede elever og begavede elever med lærevansker, og har følgende tittel: Læreren og spesialpedagogens møte med begavede elever og begavede elever med lærevansker. Forskning har hittil vist at begavede elever ikke får tilpasset opplæring som de har behov for, og det råder en holdning om at begavede elever klarer seg selv. Formålet med denne oppgaven er å gi et innblikk i hvordan lærere og spesialpedagoger møter begavede elever og begavede elever med lærevansker. Hvilken...

  1. Ion Sources for MedAustron

    CERN Document Server

    Lettry, J; Wallner, J; Sargsyan, E; CERN. Geneva. BE Department

    2010-01-01

    The MedAustron Ion therapy center will be constructed in Wiener Neustadt (Austria) in the vicinity of Vienna. Its accelerator complex consists of four ion sources, a linear accelerator, a synchrotron and a beam delivery system to the three medical treatment rooms and to the research irradiation room. The ion sources shall deliver beams of H31+, C4+ and light ions with utmost reliability and stability. This paper describes the features of the ion sources presently planned for the MedAustron facility; such as ion source main parameters, gas injection, temperature control and cooling systems. A dedicated beam diagnostics technique is proposed in order to characterize ECR ions beams; in the first drift region after the ion source, a fraction of the mixed beam is selected via moveable aperture. With standard beam diagnostics, we then aim to produce position-dependant observables such as ion-current density, beam energy distribution and emittance for each charge states to be compared to simulations of ECR e-heating...

  2. MedAustron board visits CERN

    CERN Multimedia

    CERN Bulletin

    On 14 October, the board of EBG MedAustron, which is overseeing the construction of Austria’s hadron therapy centre, visited CERN. The visit recognized the relationship of shared knowledge, technology and training between CERN and MedAustron.   Normal.dotm 0 0 1 17 98 cern 1 1 120 12.0 0 false 18 pt 18 pt 0 0 false false false /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin-top:0cm; mso-para-margin-right:0cm; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0cm; line-height:115%; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin;} ...

  3. Digital kommunikation med den offentlige sektor

    DEFF Research Database (Denmark)

    Berger, Jesper Bull; Andersen, Kim Normann

    Denne rapport sammenfatter hovedresultaterne af en undersøgelse gennemført i juni måned 2013 om besvarelse af e-mail og digital post i den statslige, regionale og kommunale sektor. Allerede med eDag3 1. nov. 2010 skulle alle myndigheder have oprettet en digital postkasse, som borgerne kunne skrive...... til. I denne undersøgelse sættes der fokus på myndighedernes besvarelse af den digitale post. Digital post blev bl.a. etableret som et alternativ til almindelig e-mail for at det offentlige kan kommunikere med borgere og virksomheder på en sikker måde, dvs. uden at uvedkommende kan få adgang til...... følsomme oplysninger. Fokus for undersøgelsen er hvordan håndterer myndighederne besvarelserne i den digitale postkasse: svarer de på digital post og e-mail, hvor hurtigt svarer de og er svarene brugbare? Undersøgelsen medtager myndighedernes besvarelse af digital post og e-mail, dels for at kunne...

  4. COSMO-SkyMed and GIS applications

    Science.gov (United States)

    Milillo, Pietro; Sole, Aurelia; Serio, Carmine

    2013-04-01

    Geographic Information Systems (GIS) and Remote Sensing have become key technology tools for the collection, storage and analysis of spatially referenced data. Industries that utilise these spatial technologies include agriculture, forestry, mining, market research as well as the environmental analysis . Synthetic Aperture Radar (SAR) is a coherent active sensor operating in the microwave band which exploits relative motion between antenna and target in order to obtain a finer spatial resolution in the flight direction exploiting the Doppler effect. SAR have wide applications in Remote Sensing such as cartography, surface deformation detection, forest cover mapping, urban planning, disasters monitoring , surveillance etc… The utilization of satellite remote sensing and GIS technology for this applications has proven to be a powerful and effective tool for environmental monitoring. Remote sensing techniques are often less costly and time-consuming for large geographic areas compared to conventional methods, moreover GIS technology provides a flexible environment for, analyzing and displaying digital data from various sources necessary for classification, change detection and database development. The aim of this work si to illustrate the potential of COSMO-SkyMed data and SAR applications in a GIS environment, in particular a demostration of the operational use of COSMO-SkyMed SAR data and GIS in real cases will be provided for what concern DEM validation, river basin estimation, flood mapping and landslide monitoring.

  5. Circulating and in situ lymphocyte subsets and Langerhans cells in patients with compositae oleoresin dermatitis and increased ultraviolet A sensitivity during treatment with azathioprine

    Energy Technology Data Exchange (ETDEWEB)

    Baadsgaard, O.

    1986-04-01

    Circulating and in situ lymphocyte subsets and Langerhans cells in four patients with compositae oleoresin dermatitis and increased ultraviolet A sensitivity before and during treatment with azathioprine were estimated. It was found that the number of Leu 6+ Langerhans cells decreased during therapy. This decrease was accompanied by a reduction in the number of Leu 2a+, Leu 3a+, Leu 4+, DR+, and Leu M2+ cells in the blood and a reduction in the number of Leu 2a+, Leu 3a+, Leu 4+, and DR+ cells in the skin. Concomitantly with the changes in the number of immunocompetent cells, the eczema cleared.

  6. Circulating and in situ lymphocyte subsets and Langerhans cells in patients with compositae oleoresin dermatitis and increased ultraviolet A sensitivity during treatment with azathioprine

    International Nuclear Information System (INIS)

    Circulating and in situ lymphocyte subsets and Langerhans cells in four patients with compositae oleoresin dermatitis and increased ultraviolet A sensitivity before and during treatment with azathioprine were estimated. It was found that the number of Leu 6+ Langerhans cells decreased during therapy. This decrease was accompanied by a reduction in the number of Leu 2a+, Leu 3a+, Leu 4+, DR+, and Leu M2+ cells in the blood and a reduction in the number of Leu 2a+, Leu 3a+, Leu 4+, and DR+ cells in the skin. Concomitantly with the changes in the number of immunocompetent cells, the eczema cleared

  7. Behandling af demenssygdomme--hvem skal behandles?

    DEFF Research Database (Denmark)

    Hasselbalch, Steen; Kampmann, Jens Peter

    2009-01-01

    Recommendations for treatment with specific antidementia drugs in Denmark are given on the basis of recent evidence. Such evidence supports treatment of mild to moderate Alzheimer's Disease (AD) with acetylcholinesterase inhibitors (AchEI), and moderate to severe AD with memantine. Combination...... therapy with these drugs can be considered in moderate AD. Dementia with Lewy bodies and Parkinson's disease with dementia should be treated with rivastigmine. There is not sufficient evidence to recommend treatment with AchEI or memantine in pure vascular dementia or frontotemporal dementia...

  8. Upplevelsen av kontakten med sjukvården : En litteraturstudie om hur vuxna personer med typ 2 diabetes upplever kontakten med sjukvården

    OpenAIRE

    Petersson, David; Sunesson, Andreas

    2008-01-01

    Bakgrund: Diabetes typ 2 är en av de stora folksjukdomarna runt om i världen och antalet som insjuknar ökar. Ett livslångt levene med sjukdomen diabetes typ 2 kan förutom omfattande livsstilsförändringar innebära en intensiv kontakt med sjukvården. För att förstå personers erfarenheter av vården måste deras upplevelser bejakas. Syfte: Syftet med studien var att belysa hur vuxna personer med typ 2 diabetes upplevde kontakten med sjukvården. Metod: Metoden som användes var litteraturstudie. Res...

  9. Pilotstudie: skriftligt arbejde med egen studiekompetence

    DEFF Research Database (Denmark)

    Christensen, Torben Spanget

    2009-01-01

    Det internationale område (dio) er et skriftligt projektarbejde i hhx. Det radikalt nye i dio'en i forhold til traditionelt skriftligt projektarbejde er, at eleven eksplicit skal arbejde med sin egen studiekompetence. Elevens arbejde skal munde ud i en rapport, som har fire bestanddele, dels en...... tværgående forløb, studieområdet (SO), som dio'en er afslutningen på. I artiklen opstilles nogle refleksionsmodeller, som kan benyttes i alle former for fællesfaglig vejledning af eleverne og der gives et bud på nogle bedømmelseskriterier for fællesfaglige projektopgaver....

  10. Med historierne og flowet i centrum

    DEFF Research Database (Denmark)

    Kabel, Lars

    2014-01-01

    Historier, 16-17 timer i døgnet, året rundt på alle platforme, også de kuraterede og sociale medier. En endeløs strøm af data i realtid, der danner udgangspunkt for indholdsstrømmene i de måske 10-15 forskellige medier, platforme, kanaler og videoservere, som mediehuse, virksomheder og...... journalistisk værdiska- belse. Nye videoformater, der gør op med de klassiske konventioner. En model for et professionelt workflow i de sociale medier. I fire artikler udforsker rappor- ten helt centrale elementer af multimedieflowet via en række cases og giver for første gang et sammenhængende bud på, hvad...

  11. Prospective Evaluation of Pharmacogenomics and Metabolite Measurements upon Azathioprine Therapy in Inflammatory Bowel Disease: An Observational Study.

    Science.gov (United States)

    Fangbin, Zhang; Xiang, Gao; Liang, Ding; Hui, Liu; Xueding, Wang; Baili, Chen; Huichang, Bi; Yinglian, Xiao; Peng, Cheng; Lizi, Zhao; Yanjun, Chu; Feng, Xu; Minhu, Chen; Min, Huang; Pinjin, Hu

    2016-04-01

    Up to approximately 40% to 50% of patients discontinue thiopurine therapy during the course of inflammatory bowel disease (IBD). We investigated the role of the metabolite thiopurine in IBD treatment. This was a prospective study.IBD patients receiving azathioprine (AZA) were prospectively included. Thiopurine methyltransferase (TPMT) genotypes were examined before therapy, and thiopurine metabolite levels were examined at weeks 2, 4, 8, 12, 24, and 48. In total, 132 patients were included. The frequency of leucopenia increased at 6-thioguanine nucleotide (6-TGN) levels ≥420 pmol/8 × 10 RBC (odds ratio [OR] = 7.9; 95% confidence interval (95%CI): 3.5-18.0; P < 0.001) and increased more during the initial 12 weeks of thiopurine therapy (OR = 16.0; 95%CI: 5.7-44.9; P < 0.001). The patients with 6-TGN levels ≥420 pmol/8 × 10 RBC at weeks 4, 8, and 12 had an increased likelihood of leucopenia. Clinical response increased at 6-TGN levels ≥225 pmol/8 × 10 RBC (OR = 13.5; 95% CI: 3.7-48.9; P < 0.001) in Crohn disease (CD) patients. The CD patients with 6-TGN levels ≥225 pmol/8 × 10 RBC at weeks 8, 12, and 24 had an increased likelihood of successful clinical response. TPMT*3C had a specificity of 100%, but a sensitivity of 8% for predicting leucopenia.A 6-TGN level between 225 and 420 pmol/8 × 10 RBC could be a therapeutic window in patients receiving AZA therapy, and it could likely predict leucopenia in the initial 12 weeks of AZA therapy and a reasonable chance of successful clinical response in CD patients. The value of TPMT genotyping before thiopurine therapy is limited in Chinese patients with IBD, considering the low sensitivity of predicting leucopenia. PMID:27082580

  12. Brukermedvirkning i arbeid med individuell plan : - anerkjennelse og krenkelse

    OpenAIRE

    Humerfelt, Kristin

    2012-01-01

    Denne avhandlingen handler om individuell plan i forhold til brukere med rusmiddelproblemer, og med et særlig fokus på brukermedvirkning. Hensikten med studien har vært å få kunnskap om individuell plan er et nyttig redskap for brukere med omfattende rusmiddelproblemer. Dette er problematisert gjennom et fokus på om individuell plan fører til at brukerne mottar koordinerte, helhetlige og individuelt tilpassete tjenester og hva som fremmer og hemmer brukermedvirkning i dette arbeidet. Studien ...

  13. Med-arb and arb-med procedures in conflicts among professionals in agriculture

    OpenAIRE

    Alecu, Ioan Niculae; Ciocan, Felix-Dimitrie; Nicolae, Horia; Ciocan, Mihut Miki

    2015-01-01

    Disputes among professionals in agronomy are generally caused by failure in performing a contract, most often the result of unclear formulations or of some flaws in drafting a contract. These arise from a failure to observe objective law, the non-satisfaction of subjective law and a failure to perform one's obligations. These are moments when Med-Arb is needed to resolve disputes and preserve business relationships between farmers. First, we must emphasize that the ADR (Alternative Dispute Re...

  14. Problematika razmerja med notranjim revizorjem in nadzornim svetom – primerjava med Slovenijo, Nemčijo in ZDA

    OpenAIRE

    Mesarič, Patrik

    2016-01-01

    V diplomskem delu primerjamo razmerja med notranjim revizorjem in nadzornim svetom v dvotirnem sistemu upravljanja z razmerji med notranjim revizorjem in upravnim odborom enotirnega sistema upravljanja. Primerjavo izpeljujemo na osnovi razlik med korporacijskim pravom Nemčije, ki predvideva dvotirne sisteme, ter korporacijskim pravom ZDA, ki predvideva enotirne sisteme. Primerjavo apliciramo na pravni red in prakso slovenskega okolja, kjer se lahko družbe odločajo tako za en...

  15. Mars 2020 Entry, Descent and Landing Instrumentation (MEDLI2)

    Science.gov (United States)

    Bose, Deepak; Wright, Henry; White, Todd; Schoenenberger, Mark; Santos, Jose; Karlgaard, Chris; Kuhl, Chris; Oishi, TOmo; Trombetta, Dominic

    2016-01-01

    This paper will introduce Mars Entry Descent and Landing Instrumentation (MEDLI2) on NASA's Mars2020 mission. Mars2020 is a flagship NASA mission with science and technology objectives to help answer questions about possibility of life on Mars as well as to demonstrate technologies for future human expedition. Mars2020 is scheduled for launch in 2020. MEDLI2 is a suite of instruments embedded in the heatshield and backshell thermal protection systems of Mars2020 entry vehicle. The objectives of MEDLI2 are to gather critical aerodynamics, aerothermodynamics and TPS performance data during EDL phase of the mission. MEDLI2 builds up the success of MEDLI flight instrumentation on Mars Science Laboratory mission in 2012. MEDLI instrumentation suite measured surface pressure and TPS temperature on the heatshield during MSL entry into Mars. MEDLI data has since been used for unprecedented reconstruction of aerodynamic drag, vehicle attitude, in-situ atmospheric density, aerothermal heating, transition to turbulence, in-depth TPS performance and TPS ablation. [1,2] In addition to validating predictive models, MEDLI data has highlighted extra margin available in the MSL forebody TPS, which can potentially be used to reduce vehicle parasitic mass. MEDLI2 expands the scope of instrumentation by focusing on quantities of interest not addressed in MEDLI suite. The type the sensors are expanded and their layout on the TPS modified to meet these new objectives. The paper will provide key motivation and governing requirements that drive the choice and the implementation of the new sensor suite. The implementation considerations of sensor selection, qualification, and demonstration of minimal risk to the host mission will be described. The additional challenges associated with mechanical accommodation, electrical impact, data storage and retrieval for MEDLI2 system, which extends sensors to backshell will also be described.

  16. 47 CFR 95.628 - MedRadio transmitters.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false MedRadio transmitters. 95.628 Section 95.628... SERVICES Technical Regulations Technical Standards § 95.628 MedRadio transmitters. (a) Frequency monitoring...Radio transmitters that are capable of operating on multiple channels may transmit on the...

  17. NASILJE MED VRSTNIKI V DRUGEM TRILETJU OSNOVNE ŠOLE

    OpenAIRE

    Plošnik, Lucija

    2012-01-01

    Diplomsko delo z naslovom Nasilje med vrstniki v drugem triletju osnovne šole je razdeljeno na teoretični in empirični del. Teoretični del obsega najprej sam opis pojava – bullying. Kasneje preidemo na oblike nasilja in spregovorimo o značilnostih vpletenih v nasilje med vrstniki

  18. Spilleregler i musikterapi med børn

    DEFF Research Database (Denmark)

    Holck, Ulla

    Artiklen gennemgår udvalgte eksempler på anvendelse af spilleregler i musikterapi med børneklientgrupper. Efter en kort introduktion af Priestleys syn på analytisk musikterapi med børn, præsenteres læseren således for en række caseeksempler fra faglitteraturen, der giver indblik i udformning og...

  19. Tandlæger og personer med en spiseforstyrrelse

    DEFF Research Database (Denmark)

    Gehrt, Charlotte Astrid; Christensen, Lisa Bøge; Klinker, Sabine;

    2016-01-01

    Mødet mellem tandlæge og patient med spiseforstyrrelse Introduktion og formål: Det er velkendt, at tandlæger kan spille en rolle i forhold til tidlig identifikation af en spiseforstyrrelse. Der erimidlertid begrænset viden om, hvilke forventninger tandlæger og personer med en spiseforstyrrelse ha...

  20. Further confirmation of the MED13L haploinsufficiency syndrome

    NARCIS (Netherlands)

    van Haelst, M.M.; Monroe, G.R.; Duran, K.J.; van Binsbergen, E.; Breur, J.M.P.J.; Giltay, J.C.; van Haaften, G.W.

    2015-01-01

    MED13L haploinsufficiency syndrome has been described in two patients and is characterized by moderate intellectual disability (ID), conotruncal heart defects, facial abnormalities and hypotonia. Missense mutations in MED13L are linked to transposition of the great arteries and non-syndromal intelle

  1. Erfaringer med mobning fra barndommen og det levede liv

    DEFF Research Database (Denmark)

    Mathiassen, Charlotte; Viala, Eva Silberschmidt

    2009-01-01

    Gennem analyser af konkret levet liv med mobning i 1950érnes og 1960érnes skoleliv sættes der fokuspå menneskers erfaringer med mobning og deres position i en given historisk og sociokulturel kontekst. På den baggrund argumenteres det, at hvis man som forsker eller praktiker ikke anstrenger sig f...

  2. Effects of inhibitors of DNA, RNA, and protein synthesis on frequencies and types of premature chromosome condensation from x-ray induced micronuclei. [Cytosine arabinoside, azathioprine, thymidine, trenimon

    Energy Technology Data Exchange (ETDEWEB)

    Madle, S.; Nowak, J.; Obe, G.

    1976-10-28

    Cells containing x-ray induced micronuclei were treated for a few hours before fixation with inhibitors of DNA synthesis (cytosine arabinoside; azathioprine; thymidine; trenimon), of RNA synthesis (actinomycin D; ethidium bromide), and of protein synthesis (puromycin). Only the inhibitors of DNA synthesis lead to a significant suppression of the frequencies of mitoses with micronucleus derived premature chromosome condensation (PCC). We tend to interpret the result as follows: Micronuclei that are in the G1 phase of their cell cycles are accumulated at the G1/S border or in the early S phase of their cell cycles under the influence of the inhibitors of the DNA synthesis. Micronuclei blocked in this way cannot be induced to undergo PCC and seem to disappear from the cells.

  3. Hemossiderose pulmonar idiopática tratada com azatioprina: relato de caso em criança Idiopathic pulmonary hemosiderosis treated with azathioprine in a child

    Directory of Open Access Journals (Sweden)

    Clemax Couto Sant`Anna

    2007-12-01

    Full Text Available A hemossiderose pulmonar idiopática (HPI, principal causa de hemossiderose pulmonar em crianças, cursa com sangramento alveolar intermitente e presença de hemossiderófagos no escarro ou no lavado gástrico. O tratamento é baseado nos corticoesteróides e citostáticos, em condições especiais. Descreve-se o caso de uma menina de sete anos com HPI, que conseguiu controle parcial da doença mediante altas doses de corticoesteróide. O tratamento, no entanto, necessitou ser suspenso gradualmente visto a paciente ter desenvolvido fácies cushingóide. Foi iniciada a associação da azatioprina ao corticóide até a substituição total por azatioprina isolada, cujo uso foi mantido por quatro anos, com ótimo resultado.Idiopathic pulmonary hemosiderosis (IPH, the main cause of pulmonary hemosiderosis in children, is characterized by intermittent alveolar bleeding and hemosiderin-laden macrophages in sputum and in gastric lavage. The treatment is based on corticosteroids and cytotoxic drugs, under special conditions. We describe the case of a 7-year-old girl with IPH who achieved partial clinical remission with high doses of corticosteroids. However, the treatment had to be discontinued because the patient developed Cushing's syndrome. Treatment was started with an azathioprine-corticosteroid combination and then changed to azathioprine alone, which was maintained for four years, with excellent results.

  4. Fatal hæmofagocytisk lymfohistiocytose og mononukleose hos en patient med colitis ulcerosa

    DEFF Research Database (Denmark)

    Juul Ingvardsen, Charlotte; Ballegaard, Vibe Cecilie; Homøe, Preben

    2012-01-01

    We report a case of Epstein-Barr virus primo infection with the development of lethal haemophagocytic lymphohistiocytosis (HLH) in a 22 year-old man, who was being treated with azathioprin for colitis ulcerosa. HLH is a rare, life-threatening disease, which is caused by an inappropriate activation...

  5. Fatal hæmofagocytisk lymfohistiocytose og mononukleose hos en patient med colitis ulcerosa

    DEFF Research Database (Denmark)

    Juul Ingvardsen, Charlotte; Ballegaard, Vibe Cecilie; Homøe, Preben

    2012-01-01

    We report a case of Epstein-Barr virus primo infection with the development of lethal haemophagocytic lymphohistiocytosis (HLH) in a 22 year-old man, who was being treated with azathioprin for colitis ulcerosa. HLH is a rare, life-threatening disease, which is caused by an inappropriate activatio...

  6. Utveckling av webbsida med användargränssnittmetoder

    OpenAIRE

    Fried, Ulrika; Hallgren, Kristina

    2005-01-01

    Restaurangen Knäppingen – Stadsmuseets Café & Kök i Norrköping var i stort behov av en marknadsförande och informativ webbsida med en administrativ del. Syftet med detta arbete var skapa en webbsida med användbarhet enligt Usability Engineerings arbetspunkter. Användbarhet innebär att ett system är ändamålsenligt, effektivt och tillfredsställande. Förutom beställarnas krav hade vi ganska stor frihet att utforma det första designförslaget. Därefter fortsatte utvecklingen av webbsidan utifr...

  7. Definition and segmentation of BioMedBridges stakeholders

    OpenAIRE

    Brooksbank, Cath; Alfarez, Deborah

    2014-01-01

    The success of BioMedBridges will depend on outreach and inreach to diverse groups of stakeholders. This deliverable report describes the use of a survey to define the broad stakeholder groups with whom BioMedBridges needs to engage, and to collect information on how the individual ESFRI-BMS RIs currently engage with these groups. We wanted to know who these stakeholders are, how the RIs are currently engaging with them, and what aspects of BioMedBridges the respondents felt we should be cons...

  8. Kvinnors upplevelser av att leva med bröstcancer

    OpenAIRE

    Music, Sanela

    2010-01-01

    Bakgrund: Bröstcancer utgör en tredjedel av all cancer som kvinnor drabbas av. Tidigare studier indikerar att kvinnor upplever mycket starka känslor kring sjukdomen bröstcancer och att de har drabbats av den. Tanken av att förlora ett bröst är en av punkterna som bringar mycket ångest och lidande. Syfte: Syftet med studien är att belysa kvinnors upplevelser av att leva med bröstcancer. Metod: En litteraturstudie med självbiografiska böcker har utförts. Studiens syfte har besvarats genom att t...

  9. Bindemiddeltesting med dynamisk skjær-reometer etter Superpave

    OpenAIRE

    Jørgensen, Torbjørn

    1998-01-01

    Et Carri-Med kontrollert skjærspennings-reometer er blitt brukt til bitumenanalyser siden 1988. SHRP-prosjektet avdekket at temperaturkontrollen var for dårlig med det orginale utstyret. Veglaboratoriet/Vegteknisk ønsket å oppgradere sitt reometer slik at temperaturkontrollen ble pålitelig. Superpave-metodene skulle dessuten etableres. Temperaturkontrollen ble oppgradert med en målecelle montert på peltier-systemet. En vannbad-sirkulator sørget for forbedret temperaturkontroll.

  10. Pragmatiske ferdigheter hos barn med cochleaimplantat : - belyst ved et kasusstudie

    OpenAIRE

    2008-01-01

    Pragmatiske ferdigheter hos barn med cochleaimplantat - belyst ved et kasusstudie. Bakgrunn: Cochleaimplantat (CI) er et høreapparat som gir sterkt hørselshemmede muligheten til å oppfatte lyd. Elektroder implanteres i sneglehuset (cochlea) og stimulerer hørselsnerven direkte (MED-EL 2006, Waltzman 2005). Forskning rundt barn med CI og deres språkutvikling har hovedsakelig vært konsentrert rundt de lingvistiske sidene ved språket (Thoutenhoofd m. fl. 2005). Like viktig vil det være å se p...

  11. Praktisk database-administrasjon med persistens av objektorienterte systemer : kompendium

    OpenAIRE

    Hansson, Knut W.

    2012-01-01

    Ved Høgskolen i Buskerud, bachelorstudiene i IT, undervises kurset "Praktisk databaseadministrasjon". Kurset består av to hoveddeler: En del fokuserer på teori om store databaser i praksis og en annen del er praktisk med bruk av Oracle (PL/SQL og objekter) og persistens av objektorienterte systemer med Visual C# og NoSQL teknikker. Den teoretiske delen foreleses og er gjenstand for vanlig, skriftlig, individuell eksamen. Den praktiske delen undervises med sterk vekt på det prak...

  12. Musikterapi med kontakt- og kommunikationssvage børn

    DEFF Research Database (Denmark)

    Frederiksen, Britta Vinkler

    2009-01-01

    I artiklen beskrives, hvordan musikterapi er med til at støtte en målrettet udviklingsproces hos børn, med diagnoser som Asperger syndrom, autisme, opmærksomhedsforstyrrelser, ADHD o.lign. Musikkens kvaliteter beskrives og illustreres gennem vignetter fra terapiforløb, der alle er foregået i Klin...... for Musikterapi, Turesensgade 15, København. Forløbene er blevet mulige efter en velgørenhedskoncert på Hard Rock Café i København til fordel for musikterapi med børn....

  13. The Arabidopsis mediator complex subunits MED16, MED14, and MED2 regulate mediator and RNA polymerase II recruitment to CBF-responsive cold-regulated genes.

    Science.gov (United States)

    Hemsley, Piers A; Hurst, Charlotte H; Kaliyadasa, Ewon; Lamb, Rebecca; Knight, Marc R; De Cothi, Elizabeth A; Steele, John F; Knight, Heather

    2014-01-01

    The Mediator16 (MED16; formerly termed SENSITIVE TO FREEZING6 [SFR6]) subunit of the plant Mediator transcriptional coactivator complex regulates cold-responsive gene expression in Arabidopsis thaliana, acting downstream of the C-repeat binding factor (CBF) transcription factors to recruit the core Mediator complex to cold-regulated genes. Here, we use loss-of-function mutants to show that RNA polymerase II recruitment to CBF-responsive cold-regulated genes requires MED16, MED2, and MED14 subunits. Transcription of genes known to be regulated via CBFs binding to the C-repeat motif/drought-responsive element promoter motif requires all three Mediator subunits, as does cold acclimation-induced freezing tolerance. In addition, these three subunits are required for low temperature-induced expression of some other, but not all, cold-responsive genes, including genes that are not known targets of CBFs. Genes inducible by darkness also required MED16 but required a different combination of Mediator subunits for their expression than the genes induced by cold. Together, our data illustrate that plants control transcription of specific genes through the action of subsets of Mediator subunits; the specific combination defined by the nature of the stimulus but also by the identity of the gene induced. PMID:24415770

  14. The effects of real-time telemedicine video consultations between nurses and patients with severe Chronic Obstructive Pulmonary Disease (COPD)

    DEFF Research Database (Denmark)

    Sorknæs, Anne Dichmann

    Formålet med ph.d. studiet var at undersøge effekten af telekonsultationer som supplement til konventionel behandling sammenlignet med konventionel behandling hos udskrevne patienter med KOL med fokus på genindlæggelser, dødelighed, sundhedsøkonomi, sygeplejerskers og patienters oplevelse af tele...

  15. Intensiv musik- og psykomotorisk gruppeterapi m. flygtninge

    DEFF Research Database (Denmark)

    Beck, Bolette Daniels; Telcs, Cathrine

    2014-01-01

    Evaluering af gruppemusikterapi i kombination med psykomotorisk behandling med 3 traumatiserede flygtninge ved hjælp af spørgeskemaer ( WHOQOL) og interviews.......Evaluering af gruppemusikterapi i kombination med psykomotorisk behandling med 3 traumatiserede flygtninge ved hjælp af spørgeskemaer ( WHOQOL) og interviews....

  16. Økologisk mælkeproduktion: Resultater fra forsøg med selvforsyning med økologisk foder

    OpenAIRE

    Mogensen, Lisbeth; Kristensen, Troels

    2001-01-01

    Ved ad libitum foder med en stor andel kløvergræsensilage af god kvalitet gav en ration med byg som tilskudsfoder den samme ydelse som en ration med rapskage og byg . Ved en mindre gunstig grovfodersituation var der en stor effekt af en A-blanding som tilskudsfoder i stedet for byg. Selv ved en stor andel ad libitum foder af god kvalitet kunne grønpiller af standard kvalitet erstatte byg på tørstofbasis uden at EKM-ydelsen faldt signifikant. Ved samme areal til rådighed pr. ko, resulterer dyr...

  17. ADHD Meds Tied to Lower Bone Density in Kids

    Science.gov (United States)

    ... nlm.nih.gov/medlineplus/news/fullstory_157591.html ADHD Meds Tied to Lower Bone Density in Kids ... 3, 2016 (HealthDay News) -- Children on medications for attention deficit hyperactivity disorder (ADHD) may have lower bone density than their ...

  18. Alcohol Abuse Common Among Med Students, Study Finds

    Science.gov (United States)

    ... nlm.nih.gov/medlineplus/news/fullstory_157800.html Alcohol Abuse Common Among Med Students, Study Finds Research ... with burnout, the cost of medical education and alcohol abuse," she said in a Mayo news release. ...

  19. U.S. Pays Highest Prices for Cancer Meds

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_159218.html U.S. Pays Highest Prices for Cancer Meds: Study However, ... cancer drugs than Americans, he said, even though U.S. monthly drug prices are about three to six ...

  20. Many Addicts Going without Meds That Curb Opioid Abuse

    Science.gov (United States)

    ... Many Addicts Going Without Meds That Curb Opioid Abuse In 2013, just 17 percent were given drugs ... in the grip of an epidemic of opioid abuse. However, new research suggests that drugs that help ...

  1. MedWatch Safety Alerts for Human Medical Products

    Data.gov (United States)

    U.S. Department of Health & Human Services — MedWatch alerts provide timely new safety information on human drugs, medical devices, vaccines and other biologics, dietary supplements, and cosmetics. The alerts...

  2. More College Students Misusing ADHD Med as Study Aid

    Science.gov (United States)

    ... nih.gov/medlineplus/news/fullstory_157280.html More College Students Misusing ADHD Med as Study Aid Nonmedical use ... 16, 2016 TUESDAY, Feb. 16, 2016 (HealthDay News) -- College students aiming for an academic edge may explain a ...

  3. Skipping Meds Greatly Ups Heart Patients' Risk of Stroke

    Science.gov (United States)

    ... Skipping Meds Greatly Ups Heart Patients' Risk of Stroke: Study Fatal strokes seven times more likely if drugs to control ... are much more likely to die from a stroke if they don't take cholesterol-lowering statin ...

  4. ADHD Meds May Pose Heart Risks for Some Kids

    Science.gov (United States)

    ... ADHD Meds May Pose Heart Risks for Some Kids Study found slightly higher chance of irregular heartbeat ... when putting a child on methylphenidate, Pratt added. Kids with existing congenital heart disease are most affected ...

  5. Behandling af infantile spasmer

    DEFF Research Database (Denmark)

    Hansen, Lars Kjaersgård; Rasmussen, Niels Henrik

    2006-01-01

    Infantile spasms (IS) are characterised by neurodevelopmental regression, a unique type of seizures and a hypsarrhythmic EEG pattern. Studies recommend the medical treatment of IS as a positive short-term outcome with respect to the spasms and in the resolution of the hypsarrhythmia. However, the...

  6. Behandling af Dupuytrens kontraktur

    DEFF Research Database (Denmark)

    Raundrup Kornø, Maj; Søe, Niels Henrik; Dahlin, Lars B

    2015-01-01

    Dupuytren’s disease treatment Dupuytren’s disease is a hereditary fibroproliferative disease commonly affecting the palmar fascia of the hand, which results in progressive and irreversibly fixed flexion contractures of the hand. It may occur in the sole of the foot or in the penis. Gen­erally, tr......Dupuytren’s disease treatment Dupuytren’s disease is a hereditary fibroproliferative disease commonly affecting the palmar fascia of the hand, which results in progressive and irreversibly fixed flexion contractures of the hand. It may occur in the sole of the foot or in the penis. Gen...

  7. Samfundserhvervet pneumoni--behandling

    DEFF Research Database (Denmark)

    Andersen, Ljubica; Brock, Birgitte; Jakobsen, Preben;

    2008-01-01

    Penicillin is the drug of choice for treatment of community-acquired pneumonia (CAP) in Denmark. The primary determinant for therapeutic activity of penicillin is ''penicillin time'' (T>MIC), i.e. time with penicillin concentration above minimum inhibitory concentration. Eradication of S....... pneumoniae requires T>MIC above 40-50%. The second determinant for therapeutic activity is the ratio between maximum penicillin concentration in serum and MIC (Cmax/MIC). Considering penicillin pharmacokinetics, intravenous penicillin 2 million units four times a day is recommended as empirical treatment of...

  8. Behandling af lokaliseret prostatacancer

    DEFF Research Database (Denmark)

    Jakobsen, Henrik; Iversen, Peter; Mikines, Kári J; Nørgaard, Nis; Høyer, Morten

    2007-01-01

    vesicles performed as an open procedure or laparoscopically, external beam radiation therapy, or implantation of radioactive seeds into the prostate (brachytherapy). In older patients with good prognostic factors, active surveillance should be considered. The various therapeutic modalities are reviewed...

  9. Behandlingsresistent depression kan behandles

    DEFF Research Database (Denmark)

    Vinberg, Maj; Levinsen, Mette Frandsen; Kessing, Lars Vedel

    2011-01-01

    Depression is considered resistant when two treatment attempts with antidepressants from different classes fail to produce significant clinical improvement. In cases of treatment-resistant depression, it is recommended to reevaluate the diagnosis, clarify comorbidity, substance abuse and lack...... of compliance. Regarding treatment, evidence is sparse, but switching to a different antidepressant, and combination or augmentation with another agent, admission and treatment with ECT are the options. The choice of treatment must be based on the characteristics of the depression, the severity of treatment...

  10. Korrekt behandling af forfrysninger

    DEFF Research Database (Denmark)

    El-Charnoubi, Waseem Ghulam; Bonde, Christian; Alsbjørn, Bjarne F

    2011-01-01

    Frostbite is rare in Denmark and is often associated with psychiatric conditions or drug- and alcohol abuse. It is seen regularly in countries with an arctic climate and tradition for outdoor activities such as skiing and climbing. The past winter in Denmark was long and cold, so we may see this...

  11. Gentaget selvmordsforebyggende behandling

    DEFF Research Database (Denmark)

    Lind, Bertel

    2014-01-01

    ramme er casestudie (Yin 2009; George 2005; Flyvbjerg 1991). Casestudiet består af en række patientforløb, hvor hver patient har haft mere end ét registreret behandlingsforløb i databasen (n = 377). Kvantitativ undersøgelse blev udført ved hjælp af Microsoft SPSS 21 på de 377 patienter på baggrund af...

  12. The YLI-MED Corpus: Characteristics, Procedures, and Plans

    OpenAIRE

    Bernd, Julia; Borth, Damian; Elizalde, Benjamin; Friedland, Gerald; Gallagher, Heather; Gottlieb, Luke; Janin, Adam; Karabashlieva, Sara; Takahashi, Jocelyn; Won, Jennifer

    2015-01-01

    The YLI Multimedia Event Detection corpus is a public-domain index of videos with annotations and computed features, specialized for research in multimedia event detection (MED), i.e., automatically identifying what's happening in a video by analyzing the audio and visual content. The videos indexed in the YLI-MED corpus are a subset of the larger YLI feature corpus, which is being developed by the International Computer Science Institute and Lawrence Livermore National Laboratory based on th...

  13. Sprog hos børn med autisme

    DEFF Research Database (Denmark)

    Brynskov, Cecilia

    2010-01-01

    Spredningen i sproglige færdigheder hos børn med autisme er enorm. Dette forhold vanskeliggør forskning inden for området, og omvendt bevirker forskningen og de valg – og ikke mindst fravalg – som autismeforskere er nødt til at foretage, at gruppen af børn med autisme kommer til at fremstå mere...

  14. ANALIZA KORELACIJ MED ZADOVOLJSTVOM S KOMUNICIRANJEM V ORGANIZACIJI IN STRESOM

    OpenAIRE

    Matjan, Samo

    2011-01-01

    Namen diplomske naloge je bilo ugotoviti ali obstajajo korelacije med zadovoljstvom s komuniciranjem v organizaciji in stresom. Z raziskavo smo želeli prispevati k boljšemu razumevanju tesne povezanosti med zadovoljstvom s komuniciranjem v organizacijah in stresom. V teoretičnem delu diplome analiziramo pojem stresa in njegove posledice na posameznika in organizacijo v kateri je zaposlen. Analizirali smo pojem komuniciranja, vrste in načini komuniciranja,tehnike in metode komuniciranja,...

  15. PubMed searches: overview and strategies for clinicians.

    Science.gov (United States)

    Lindsey, Wesley T; Olin, Bernie R

    2013-04-01

    PubMed is a biomedical and life sciences database maintained by a division of the National Library of Medicine known as the National Center for Biotechnology Information (NCBI). It is a large resource with more than 5600 journals indexed and greater than 22 million total citations. Searches conducted in PubMed provide references that are more specific for the intended topic compared with other popular search engines. Effective PubMed searches allow the clinician to remain current on the latest clinical trials, systematic reviews, and practice guidelines. PubMed continues to evolve by allowing users to create a customized experience through the My NCBI portal, new arrangements and options in search filters, and supporting scholarly projects through exportation of citations to reference managing software. Prepackaged search options available in the Clinical Queries feature also allow users to efficiently search for clinical literature. PubMed also provides information regarding the source journals themselves through the Journals in NCBI Databases link. This article provides an overview of the PubMed database's structure and features as well as strategies for conducting an effective search. PMID:23442731

  16. Feed and Feed Preheating Effect on MED-TVC Enhancement

    International Nuclear Information System (INIS)

    Rapid and significant growth of world installed capacity of Reverse Osmosis (RO) followed by Multi-Effect Distillation (MED) has taken place year after year. Efforts are made to improve the system performance through increasing productivity and lowering specific power consumption by utilizing waste heat for seawater feed pre heat. The present work studies the importance of seawater pre heating in MED by utilizing power plants condenser cooling water. A steady state mathematical model for Multi - Effect Distillation combined with Thermal Vapor Compression (MED-TVC) system and the governing equations are solved using a computer program to evaluate the MED-TVC system performance. The model validity is examined by data collected from two MED - TVC plants which showed good agreement. Furthermore; the study results show that an increase of seawater feed temperature from 32 to 46 degree C enhances the system productivity. Also, it increases the Gain Output Ratio by 8.7%, and decreases the specific heat consumption and the heat transfer are a by 9.6% and 17.4% respectively

  17. GPIB- kommunikation och PID reglering med LabVIEW

    OpenAIRE

    Abbas, Azhar

    2009-01-01

    LabVIEW ger en snabb och enkel tillgång till att styra instrument och en mycket stor databas med drivrutiner för DAQ-kort och olika datorgränssnitt (GPIB, serie, osv.). Många instrument och datorer kan anslutas till GPIB-bussen.  Detta kan ge en praktisk modell för utveckling av instrumentets styrprogram i LabVIEW med hjälp av GPIB-gränssnittet. Ett program i LabVIEW 8.2 med hjälp av GPIB-bussen kan kopplas till t.ex. multimetern (HP-34401A) för att mäta och visa multimeters noggrannhet. Men ...

  18. Handledning på distans : Handledning med tematiken kost

    OpenAIRE

    Bergman, Hanna; Ratus, Jannice; Riikonen, Bettina; Åhman, Alexandra

    2015-01-01

    Abstrakt Detta examensarbete är en del inom projektet ”Det resursstarka barnet”. Syftet med arbetet är att pröva om virtuell handledning av barn i 4-års åldern fungerar. Målet är att pröva om virtuell handledning med barn fungerar och därmed skapa en checklista med tips och råd för den professionella att tillämpa i praktiskt arbete. Frågeställningen för arbetet är: Fungerar handledning av barn på distans via en surfplatta?” och ”Vad skall handledaren tänka på då hen handleder barn virtuel...

  19. Ergoterapeuters arbete med hund som en del av ergoterapiprocessen

    OpenAIRE

    Löfroth, Linnéa

    2012-01-01

    Som bakgrund till mitt examensarbete står det positiva bandet människan och hunden emellan samt hundens fördelaktiga påverkan på människans välmående. Syftet med arbetet är att redogöra för hur ergoterapeuter arbetar med hund som en del av klientens ergoterapiprocess samt redogöra för hur ergoterapeuter resonerar kring arbetet med hund som en del av ergoterapin. Föreningen Hundar inom fostran och rehabilitering rf är min undersöknings samarbetspartner. Som teoretisk referensram står den Canad...

  20. Tunnelerede centrale venekatetre til børn med cancer

    DEFF Research Database (Denmark)

    Schrøder, Henrik; Malchau, Emma; Larsen, Line Nordahl; Bugge, Kristina; Olsen, Lars Henning; Kamperis, Konstantinos

    2008-01-01

    overlevelsen af det først anlagte TCVK hos børn med nydiagnosticeret cancer. Materiale og metoder: I studiet indgår der oplysninger om alle børn med cancer, der fra den 1. januar 2000 til den 1. september 2006 fik anlagt et dobbeltløbet Hickman CVK (2-Hick) eller et dobbeltløbet Port-a-cath (2-PaC). Der er...... (p<0.01) korreleret til CVK-overlevelse. Konklusion: Anvendelse af dobbeltløbet Port-a-cath til børn i alle aldre er forbundet med signifikant færre fjernelser pga. komplikationer end anvendelse af Hickman CVK.  Udgivelsesdato: 28. januar 2008...

  1. Synchronously Driven Power Converter Controller Solution for MedAustron

    CERN Document Server

    Šepetavc, Luka; Tavčar, Rok; Moser, Roland; Gutleber, Johannes

    2011-01-01

    MedAustron is an ion beam cancer therapy and research centre currently under construction in Wiener Neustadt, Austria. This facility features a synchrotron particle accelerator for light ions. Cosylab is closely working together with MedAustron on the development of a power converter controller (PCC) for the 260 deployed power converters – power supplies. Power converters deliver power to magnets used for focusing and steering particle beams. We have designed and developed software and hardware which allows integration of different types of power converters into MedAustron's control system (MACS). PCC's role is to synchronously control and monitor connected power converters. Custom real-time fibre optics link and modular front end devices have been designed for this purpose. Modular front end devices make it possible to interface with almost any type of power converter – with or without built in regulation logic. We implemented realtime mechanisms and a dedicated real-time fibre link to ...

  2. Upplevelsen av att leva med diabetes mellitus typ 2

    OpenAIRE

    Nilsson, Louise; Forsander, Lina

    2016-01-01

    Diabetes typ 2 är en kronisk sjukdom som ökar över hela världen. Orsakerna till diabetes kan relateras till livsstil. En litteraturöversikt gjordes där elva artiklar med kvalitativ design granskades och analyserades. Syftet var att beskriva upplevelser av att leva med diabetes mellitus typ 2. I resultatet framkom fyra kategorier: att känna rädsla inför framtiden, känslomässiga konsekvenser av att leva med diabetes typ 2, vikten av att ha tillräcklig kunskap och att må bättre genom förändrade ...

  3. Beskrivelse af næringsstofomsætning med metabolomics

    DEFF Research Database (Denmark)

    Hedemann, Mette Skou

    I et forsøg med mink med lav eller høj foderkonvertering er der blevet taget blodprøver på tre tidspunkter. Blodprøverne er blevet taget i en periode, hvor minkene er blevet fodret restriktivt (en prøve) og i en periode med ad libitum fodring (to prøver). Blodprøverne blev analyseret ved hjælp af...... fra restriktivt fodrede mink end i plasma fra ad libitum fodrede mink - betain og carnitin. Derudover er der en lang række andre metabolitter, som også findes i forskellig koncentration som endnu ikke er identificeret....

  4. MedAustron: The Austrian ion therapy facility

    Science.gov (United States)

    Benedikt, Michael

    MedAustron is a synchrotron-based light-ion beam therapy center for cancer treatment as well as for clinical and non-clinical research in Wiener Neustadt, Austria. The center is designed for the treatment of up to 1200 patients per year and for non-clinical research in the areas of radiobiology and medical radiation physics, as well as in experimental physics. MedAustron is an interdisciplinary project, benefiting from close cooperation and knowledge transfer with medical, scientific and research institutes on the national and international level. Three medical irradiation rooms will allow quasi-permanent patient treatment during two shifts on working days. The remaining beam time will be used for non-clinical research applications in a dedicated fourth irradiation room. The expected start of operation of MedAustron is mid-2016...

  5. Utveckling av ett timrapporteringsverktyg med SharePoint

    OpenAIRE

    Ilama, Santtu

    2009-01-01

    Det här examensarbetet har två huvudsyften. I första delen presenteras Microsoft SharePoint, och i den andra delen visas genom att skapa ett timrapporteringsverktyg ett exempel på vad man kan göra med det. I SharePoint delen utreder jag först vad det är och hurdana mallar och verktyg man börjar med när man skapar en ny sajt. Sedan utreder jag skillnaderna mellan SharePoint-versionerna 3.0 och 2.0. Till slut utreder jag hur man installerar SharePoint 3.0 tillsammans med Microsoft Windows Small...

  6. Death, dying and informatics: misrepresenting religion on MedLine

    Directory of Open Access Journals (Sweden)

    Fins Joseph J

    2005-07-01

    Full Text Available Abstract Background The globalization of medical science carries for doctors worldwide a correlative duty to deepen their understanding of patients' cultural contexts and religious backgrounds, in order to satisfy each as a unique individual. To become better informed, practitioners may turn to MedLine, but it is unclear whether the information found there is an accurate representation of culture and religion. To test MedLine's representation of this field, we chose the topic of death and dying in the three major monotheistic religions. Methods We searched MedLine using PubMed in order to retrieve and thematically analyze full-length scholarly journal papers or case reports dealing with religious traditions and end-of-life care. Our search consisted of a string of words that included the most common denominations of the three religions, the standard heading terms used by the National Reference Center for Bioethics Literature (NRCBL, and the Medical Subject Headings (MeSH used by the National Library of Medicine. Eligible articles were limited to English-language papers with an abstract. Results We found that while a bibliographic search in MedLine on this topic produced instant results and some valuable literature, the aggregate reflected a selection bias. American writers were over-represented given the global prevalence of these religious traditions. Denominationally affiliated authors predominated in representing the Christian traditions. The Islamic tradition was under-represented. Conclusion MedLine's capability to identify the most current, reliable and accurate information about purely scientific topics should not be assumed to be the same case when considering the interface of religion, culture and end-of-life care.

  7. Taleteknologi for barn. En kvalitativ studie av fagpersoners erfaringer med kommunikasjonsmateriellet Pegasus.

    OpenAIRE

    Stølen, Mari

    2015-01-01

    Denne studien handler om alternativ og supplerende kommunikasjon, og har sett nærmere på taleteknologi for barn og kommunikasjonsmateriellet Pegasus. Barn med kommunikasjonsvansker har ikke samme forutsetninger som barn med typisk utvikling til å delta i sosialt samspill. Pegasus er utviklet for å hjelpe disse barna til å bli mer aktive i kommunikasjon, lek og samspill med andre. Formålet med studien var å undersøke erfaringer med å bruke Pegasus i samspill med barn med kommunikasjonsvansker....

  8. Mäns erfarenheter i samband med prostatektomi : En litteraturstudie

    OpenAIRE

    Olén, Jessica; Norenius, Caroline

    2015-01-01

    Bakgrund: Globalt sett är prostatacancer den näst vanligaste cancerformen bland män och drabbar oftast de som är över 70 år. Den vanligaste behandlingsmetoden som används kallas radikal prostatektomi och kan leda till erektionsproblematik och urininkontinens. Efter att ha genomgått prostatektomi kan även olika känslor av ångest, depression och psykologisk smärta uppkomma. Syfte: Syftet med föreliggande litteraturstudie var att belysa mäns erfarenheter i samband med prostatektomi. Metod: Syfte...

  9. Æstetisk smag – med mennesker som pynt?

    DEFF Research Database (Denmark)

    Eichberg, Henning

    2015-01-01

    Anmeldelse af Claus Bøje & Søren Riiskjær (red.): Tag på fælleden – idrættens huse. 20 år med Lokale og Anlægs-fonden. København: LOA.......Anmeldelse af Claus Bøje & Søren Riiskjær (red.): Tag på fælleden – idrættens huse. 20 år med Lokale og Anlægs-fonden. København: LOA....

  10. Musikterapi til reduktion af agitation hos personer med demens

    DEFF Research Database (Denmark)

    Ridder, Hanne Mette Ochsner; Stige, Brynjulf

    2015-01-01

    Urolig adfærd hos demensramte på plejehjem kan defineres og måles med fagbegrebet agitation. Agitation har alvorlige konsekvenser for de berørte og kan føre til fald i livskvalitet og øget medicinering hos personer med svær demens, og kan ligeledes føre til udbrændthed hos omsorgsgivere. Agitation...... regarding the single individual. A relevant method in an integrated and holistic approach is professional music therapy combined with other staffs’ use of music in daily dementia care....

  11. Razlike med slovensko in arabsko kulturo pri poslovnem komuniciranju

    OpenAIRE

    Djurović, Vanja

    2016-01-01

    V diplomskem delu smo najprej pojasnili, kaj pravzaprav je poslovno komuniciranje, kaj medkulturno komuniciranje in kaj vse zajema pojem kulture. V nadaljevanju smo predstavili značilnosti arabske in slovenske kulture v okviru poslovnega komuniciranja, na koncu pa izpostavili bistvene razlike med njima. Pri poslovanju v mednarodnem okolju je uspešna medkulturna komunikacija izjemnega pomena. Med seboj namreč poslujejo osebe, ki prihajajo iz različnih držav. Zato je za uspešno mednarodno p...

  12. Musikterapi som behandlingsform : - en intervjustudie med yrkesverksamma musikterapeuter

    OpenAIRE

    Tess, Glöckner

    2015-01-01

    Denna studie handlar om musikterapi som möjlig behandlingsform i svensk kontext. Syftet är att utforska terapiformen och dess användningsområden, med fokus på hur den kan fungera inom missbrukarvården i Sverige. Musikterapin kontrasteras mot verbala behandlingsmetoder och andra terapier. Studiens empiri utgörs av sju intervjuer med människor verksamma inom det musikterapeutiska arbetsfältet. Tre av dem är utbildade vid kungliga musikhögskolan och arbetar inom den psykodynamiskt inriktade musi...

  13. Personcentrerad omvårdnad till personer med demenssjukdom

    OpenAIRE

    Ekman, Emelie; Welander Ericsson, Marielle

    2011-01-01

    Syfte: Litteraturstudiens syfte var att beskriva åtgärder som kan användas för att ge personcentrerad omvårdnad till personer med demenssjukdom samt beskriva hur beteendemässiga och psykiska symtom vid demens (BPSD) påverkas av personcentrerad omvårdnad. Metod: Litteraturstudien innefattade 17 artiklar med såväl kvalitativ som kvantitativ ansats och söktes i databaserna Cinahl och Pubmed. Resultat: Utbildning i personcentrerad omvårdnad gav omvårdnadspersonalen ökad förståelse för personen oc...

  14. STRES IN IZGORELOST MED ŠOLSKIMI SVETOVALNIMI DELAVCI

    OpenAIRE

    Senekovič, Anja

    2013-01-01

    V diplomskem delu smo preiskovali stres in izgorelost med šolskimi svetovalnimi delavci. V teoretičnem delu so predstavljena poglavja o stresu, stresu na delovnem mestu, izgorelosti (na delovnem mestu) in o svetovalnem delu. V empiričnem delu je predstavljena raziskava, ki je bila izvedena med svetovalnimi delavci, zaposlenimi v vrtcih, osnovnih in srednjih šolah. Opravljena je bila z namenom, da bi opozorili na problem izgorevanja, ki vse pogosteje ogroža izvajalce različnih oblik pomoči. Ci...

  15. The impact of glutathione S-transferase genotype and phenotype on the adverse drug reactions to azathioprine in patients with inflammatory bowel diseases.

    Science.gov (United States)

    Liu, Hui; Ding, Liang; Zhang, Fangbin; Zhang, Yu; Gao, Xiang; Hu, Pinjin; Bi, Huichang; Huang, Min

    2015-10-01

    Azathioprine (AZA) is a thiopurine prodrug which is widely used in patients with inflammatory bowel disease (IBD). However, the use is limited in one-third of patients because of adverse drug reactions (ADRs) or a lack of clinical response. It has been considered that the polymorphic enzyme thiopurine S-methyltransferase (TPMT) plays an important role in the in vivo process of AZA and the occurrence of its myelotoxicity. Glutathione S-transferase (GST) mutation is another pharmacogenetic polymorphism which is probably involved in AZA metabolism and tolerance. The aim of this study was to investigate the association among GST polymorphism, enzyme activity and AZA-related ADRs in Chinese Han patients with IBD. We found that the patients who became neutropenic had a significantly higher GSTs activity when compared with of the patients who did not develop ADRs (analysis of variance, P GST activity constituted a pharmacogenetic high risk group for leucopenia during AZA treatment. GST-P1 Ile105/Ile105 genotype appeared to be a promising marker indicating predisposition to AZA-related ADRs. PMID:26432087

  16. The effect of methotrexate and azathioprine on the serum levels of IgA-a1-antitrypsin complex in juvenile chronic arthritis

    Directory of Open Access Journals (Sweden)

    J.K. Lacki

    1997-06-01

    Full Text Available In the present study we investigated the influence of methotrexate (MTX and azathioprine (AZA on the serum levels of the IgA-a1-antitrypsin (IgA-AT complex in patients with the systemic form of juvenile chronic arthritis (JCA. Fifty-six JCA patients (22 treated with MTX, 18 treated with AZA, and 16 not treated with any immunosuppressive agent were enrolled in the study. MTX dosage ranged from 0.3 to 0.5 mg kg-1 week-1, while AZA was given daily at an average dose of 1 mg/kg. MTX was given for 13 months (SD = 7 months whereas AZA for 11 months (SD = 6 months. The average value of the complex was higher in JCA patients than in both control groups (0.74 ± 0.73 U vs 0.37 ± 0.13 U (control children, Pa1-acid-glycoprotein (r = 0.45, Pa1-antichymotrypsin (r = 0.52, Pa1-antitrypsin (r = 0.40, P<0.01 and IgA (r = 0.56, P<0.01 was established

  17. Glassy carbon electrodes modified with a film of nanodiamond-graphite/chitosan: Application to the highly sensitive electrochemical determination of Azathioprine

    International Nuclear Information System (INIS)

    A novel modified glassy carbon electrode with a film of nanodiamond-graphite/chitosan is constructed and used for the sensitive voltammetric determination of azathioprine (Aza). The surface morphology and thickness of the film modifier are characterized using atomic force microscopy. The electrochemical response characteristics of the electrode toward Aza are investigated by means of cyclic voltammetry. The modified electrode showed an efficient catalytic role for the electrochemical reduction of Aza, leading to a remarkable decrease in reduction overpotential and enhancement of the kinetics of the electrode reaction with a significant increase of peak current. The effects of experimental variables, such as the deposited amount of modifier suspension, the pH of the supporting electrolyte, the accumulation potential and time were investigated. Under optimal conditions, the modified electrode showed a wide linear response to the concentration of Aza in the range of 0.2-100 μM with a detection limit of 65 nM. The prepared modified electrode showed several advantages: simple preparation method, high stability and uniformity in the composite film, high sensitivity, excellent catalytic activity in physiological conditions and good reproducibility. The modified electrode can be successfully applied to the accurate determination of trace amounts of Aza in pharmaceutical and clinical preparations.

  18. Glassy carbon electrodes modified with a film of nanodiamond-graphite/chitosan: Application to the highly sensitive electrochemical determination of Azathioprine

    Energy Technology Data Exchange (ETDEWEB)

    Shahrokhian, Saeed, E-mail: shahrokhian@sharif.ed [Department of Chemistry, Sharif University of Technology, Tehran 11155-9516 (Iran, Islamic Republic of); Institute for Nanoscience and Technology, Sharif University of Technology, Tehran (Iran, Islamic Republic of); Ghalkhani, Masoumeh [Department of Chemistry, Sharif University of Technology, Tehran 11155-9516 (Iran, Islamic Republic of)

    2010-04-15

    A novel modified glassy carbon electrode with a film of nanodiamond-graphite/chitosan is constructed and used for the sensitive voltammetric determination of azathioprine (Aza). The surface morphology and thickness of the film modifier are characterized using atomic force microscopy. The electrochemical response characteristics of the electrode toward Aza are investigated by means of cyclic voltammetry. The modified electrode showed an efficient catalytic role for the electrochemical reduction of Aza, leading to a remarkable decrease in reduction overpotential and enhancement of the kinetics of the electrode reaction with a significant increase of peak current. The effects of experimental variables, such as the deposited amount of modifier suspension, the pH of the supporting electrolyte, the accumulation potential and time were investigated. Under optimal conditions, the modified electrode showed a wide linear response to the concentration of Aza in the range of 0.2-100 muM with a detection limit of 65 nM. The prepared modified electrode showed several advantages: simple preparation method, high stability and uniformity in the composite film, high sensitivity, excellent catalytic activity in physiological conditions and good reproducibility. The modified electrode can be successfully applied to the accurate determination of trace amounts of Aza in pharmaceutical and clinical preparations.

  19. Værkanalyse med digitale 3D modeller

    DEFF Research Database (Denmark)

    Villaume, René Domine; Ørstrup, Finn Rude

    2006-01-01

    Projektet afprøve muligheder for Værkanalyse af danske arkitekturværker med anvendelse af digitale 3D modeller. Arkitektstuderende har i en workshop udarbejdet en 3D model af Arkitekt Vilhelm Lauritzens bygning til  Københavns Lufthavn fra 1939. Modellen er herefter videreudviklet og yderligere...

  20. By og Byg Resultater 005.Facaderenovering med glas

    DEFF Research Database (Denmark)

    Wittchen, Kim Bjarne

    Målinger i et forsøgsbyggeri med glasinddækkede altaner viser, at det er muligt at opnå store energibesparelser. Dette er sikret ved glasinddækkede altaner, luftsolfanger til forvarmning af ventilationsluften, udskiftning af vinduerne og opsætning af energialarmer. Samtidig har det været muligt a...

  1. Student employment opportunities within ORD, with an emphasis on MED

    Science.gov (United States)

    This is a talk to undergraduate Juniors and Seniors in the UW-Madison School of Pharmacy's Pharm/Tox program about student employment opportunities w/in ORD such as SSC, ORISE, etc. wtih an emphasis on MED. I would classify as this as Outreach: how to navigate EPA websites to f...

  2. Med hjerne og hjerte - et aktionsforskningsprojekt om demensomsorg

    DEFF Research Database (Denmark)

    Hansen, Helle Krogh; Rasmussen, Else Marie

    om værdier; individuelle interviews (8 pårørende og 3 frivillige); to kernekvalitetsundersøgelser (4 medarbejdere undersøgte kvaliteter og værdier ud fra D. Ofmans teori om kernekvaliteter); en kernekvalitetsundersøgelse i samarbejde med lederen; SWOT-analyser, udarbejdelse og analyse af...

  3. Specialiserede tilbud til borgere med handicap - efter reformen

    DEFF Research Database (Denmark)

    Bonfils, Inge Storgaard; Permin Berger, Nichlas

    Som en del af kommunalreformen fik kommunerne i 2007 det fulde ansvar for handicapområdet. AKF har i 2006-2010 undersøgt, hvilke forandringer brugere, medarbejdere og ledere på specialtilbuddene oplevede i forbindelse med reformen. Undersøgelsen viser, at brugerne kun har oplevet få eller ingen æ...

  4. Nitrogenoxider i køkkener med gaskomfur

    DEFF Research Database (Denmark)

    Jespersen, R.

    Meddelelsen redegør for en forundersøgelse af metode og udstyr til måling af koncentrationen af nitrogenoxider i forbindelse med anvendelse af gas i køkkener. Undersøgelsen havde desuden til formål at forberede et eventuelt større projekt til kortlægning af niveauet af nitrogenoxider....

  5. Højteknologisk dialysering i kombination med lavteknologisk sengecykling

    DEFF Research Database (Denmark)

    Mark, Edith; Agnholt, Hanne; Dollerup, Karin Hejlskov;

    Baggrund: Problemstillingen for mange hæmodialysepatienter er træthed og bundetheden til dialyseapparaturet. Det betyder, at patienterne ofte ikke har overskud til at motionere og oplever sig som passive. Forskningsprojektet giver indsigt i, hvordan ældre mennesker med kronisk nyresygdom oplever ...

  6. Grønnere skibsfart med modstandsdygtige motorer

    DEFF Research Database (Denmark)

    Lassen, Lisbeth

    2015-01-01

    Udledningen af forurening fra skibsmotorer skal sænkes kraftigt i de kommende år, og derfor står den maritime industri overfor helt nye krav til blandt andet hvilke brændstoffer, man kan bruge. På grund af de nye regler, der begrænser skibenes energiforbrug, er man også begyndt at sejle med nedsa...

  7. ADHD Meds May Pose Heart Risks for Some Kids

    Science.gov (United States)

    ... nlm.nih.gov/medlineplus/news/fullstory_159140.html ADHD Meds May Pose Heart Risks for Some Kids ... HealthDay News) -- Ritalin, a popular drug for treating attention-deficit hyperactivity disorder (ADHD), might increase the risk of an abnormal ...

  8. Notat om arbejdet med innovation i Randers Kommune

    DEFF Research Database (Denmark)

    Hansen, Morten Balle; Agger Nielsen, Jeppe

    2012-01-01

    hovedpunkter er; 1) udarbejdelse af de gode innovationsspørgsmål, 2) dobbeltudfordringen med på den ene side at sikre daglig drift og på den anden side at arbejde innovativt, 3) top-down versus bottom-up processer, dvs. hvor meget skal innovationsprocesserne designes og styres? 4) den særlige kontekst for...

  9. PubMed Central Canada: Beyond an Open Access Repository?

    Science.gov (United States)

    Nariani, Rajiv

    2013-01-01

    PubMed Central Canada (PMC Canada) represents a partnership between the Canadian Institutes of Health Research (CIHR), the National Research Council's Canada Institute for Scientific and Technical Information (NRC-CISTI), and the National Library of Medicine of the US. The present study was done to gauge faculty awareness about the CIHR Policy on…

  10. Arbejdsret med tilknyttede dele af socialretten og skatteretten

    DEFF Research Database (Denmark)

    Hasselbalch, Ole

    Lærebog og oversigtsværk indeholdende en systematisk gennemgang af hele arbejdsretten med tilknyttede dele af arbejdsmiljøretten, skatteretten og socialretten (sidstnævnte i hovedtræk). Fremstillingen er systematiseret efter retsområdets funktionelle sammenhænge, og systematikken svarer til den...

  11. Mandlig reproduktion og kemiske stoffer med østrogenlignende effekter

    DEFF Research Database (Denmark)

    Toppari, Jorma; Larsen, John Christian; Christiansen, Peter; Giwercman, Aleksander; Grandjean, Philippe; Guillette Jr., Louis J.; Jégou, Bernard; Jensen, Tina K.; Jouannet, Pierre; Keiding, Niels; Leffers, Henrik; McLachlan, John A.; Meyer, Otto A.; Müller, Jørn; Meyts, Ewa Rajpert-De; Scheike, Thomas; Sharpe, Richard; Sumpter, John; Skakkebæk, Niels E.

    Nye rapporter har påvist faldende sædkvalitet og stigende forekomst af testikelkræft og misdannelser i de mandlige kønsorganer. Årsagerne kendes ikke, men miljø- og livsstilsfaktorer menes involveret. Specielt er der peget på kemiske stoffer med virkning som det kvindelige kønshormon østrogen. De...

  12. Opfølgende hjemmebesøg med video

    DEFF Research Database (Denmark)

    Wentzer, Helle

    Denne publikation beskriver erfaringerne fra et udviklingsprojekt, hvor opfølgende hjemmebesøg kombineres med videokonference-teknologi. Projektet har bestået i at gennemføre et eksperiment, hvor video benyttes til at mediere samtalen mellem læge, hjemmesygeplejerske og den ældre medicinske patient...

  13. Primary EBV-positive Hodgkin's lymphoma of the CNS under azathioprine treatment. Case report and review of the literature

    Energy Technology Data Exchange (ETDEWEB)

    Henkenberens, Christoph; Christiansen, Hans [Medizinische Hochschule Hannover, Klinik fuer Strahlentherapie und Spezielle Onkologie, Hannover (Germany); Franzke, Anke [Medizinische Hochschule Hannover, Klinik fuer Haematologie, Haemostaseologie, Onkologie und Stammzelltransplantation, Hannover (Germany); Raab, Peter [Medizinische Hochschule Hannover, Institut fuer Diagnostische und Interventionelle Neuroradiologie, Hannover (Germany); Oschlies, Ilske; Klapper, Wolfram [Universitaetsklinikum Schleswig-Holstein, Institut fuer Pathologie, Sektion Haematopathologie, Kiel (Germany)

    2014-09-15

    Retrospective and prospective cohort studies suggest that central nervous system involvement occurs in approximately 0.5 % of patients with advanced Hodgkin's lymphoma. The isolated primary intracranial manifestation of Hodgkin's lymphoma is an extremely rare finding, with few cases reported in the literature. Little is known about the optimal treatment and prognosis of these tumors. Here, we present a case report with a review of the literature. A 47-year-old Caucasian man with persistent frontal headache and unspecific vertigo for half a month was diagnosed with nodular space-occupying lesions in the cerebellum. His medical history included multiple sclerosis, which was treated for 20 years with the immunosuppressive drug azathioprine. Further staging revealed no additional lesions suspected of being malignant. The patient underwent total tumor resection. Immunohistopathological examination showed Epstein-Barr virus-associated classic Hodgkin's lymphoma. Diagnostic bone marrow punction excluded lymphoma involvement of the bone marrow. The patient had no B symptoms. Consequently, the patient was classified as having stage I{sub E}A disease according to the Modified Ann Arbor Classification of Hodgkin Lymphoma and received systemic chemotherapy followed by radiation therapy for the former cerebellar tumor region. He was in complete clinical remission at the last follow-up 9 months after the initial diagnosis. This case report and literature review suggest that multimodal treatment leads to a remarkable clinical outcome in Hodgkin's lymphoma with intracranial involvement. (orig.) [German] Retrospektive und prospektive Kohortenstudien deuten daraufhin, dass eine Beteiligung des zentralen Nervensystems (ZNS) in etwa bei 0,5 % der Patienten mit fortgeschrittenem Hodgkin-Lymphom auftritt. Die isoliert primaer intrakranielle Manifestation des Hodgkin-Lymphoms ist extrem selten, mit wenigen bisher bekannten Faellen. Wenig ist auch ueber die optimale

  14. In-vitro immunosuppression of canine T-lymphocyte-specific proliferation with dexamethasone, cyclosporine, and the active metabolites of azathioprine and leflunomide in a flow-cytometric assay.

    Science.gov (United States)

    Nafe, Laura A; Dodam, John R; Reinero, Carol R

    2014-07-01

    A high rate of mortality, expense, and complications of immunosuppressive therapy in dogs underscores the need for optimization of drug dosing. The purpose of this study was to determine, using a flow-cytometric assay, the 50% T-cell inhibitory concentration (IC50) of dexamethasone, cyclosporine, and the active metabolites of azathioprine (6-mercaptopurine) and leflunomide (A77 1726) in canine lymphocytes stimulated with concanavalin A (Con A). Whole blood was collected from 5 privately owned, healthy dogs of various ages, genders, and breeds. Peripheral blood mononuclear cells, obtained by density-gradient separation, were cultured for 72 h with Con A, a fluorochrome-tagged cell proliferation dye, and various concentrations of dexamethasone (0.1, 1, 10, 100, 1000, and 10 000 μM), cyclosporine (0.2, 2, 10, 20, 30, 40, 80, and 200 ng/mL), 6-mercaptopurine (0.5, 2.5, 50, 100, 250, and 500 μM), and A77 1726 (1, 5, 10, 25, 50, and 200 μM). After incubation, the lymphocytes were labeled with propidium iodide and an antibody against canine CD5, a pan T-cell surface marker. Flow cytometry determined the percentage of live, proliferating T-lymphocytes incubated with or without immunosuppressants. The mean (± standard error) IC50 was 3460 ± 1900 μM for dexamethasone, 15.8 ± 2.3 ng/mL for cyclosporine, 1.3 ± 0.4 μM for 6-mercaptopurine, and 55.6 ± 22.0 μM for A77 1722. Inhibition of T-cell proliferation by the 4 immunosuppressants was demonstrated in a concentration-dependent manner, with variability between the dogs. These results represent the initial steps to tailor this assay for individual immunosuppressant protocols for dogs with immune-mediated disease. PMID:24982547

  15. Designing, Integrating, and Coordinating the Installation of MedAustron

    CERN Document Server

    Nicquevert, B; Benedikt, M

    2011-01-01

    "Give me a layout good enough and a building to place it, and I will install your accelerator". To paraphrase Archimedes, this is the role attributed to the Integration team in the MedAustron project. Starting with the optics layout and a building sketch, the integration work consists of a series of activities, interlinked in a complex manner. First the design and the integration of accelerator: list all items, define geometrical envelopes with interfaces, put them in position in CAD, identify conflicts and define input for design of items and of infrastructure. Then the various equipment is procured: verify and validate design data, follow-up manufacturing, fiducialize equipment and build supports. Lastly the global installation: check building and infrastructure, define survey framework, install and pre-align equipment on supports, move assemblies to their final location, survey actual position and adjust to theoretical position. The whole chain of operations from the layout to a real beam in MedAustron, i...

  16. L'opération Accor - Club Med

    OpenAIRE

    Grémont, Eric; Dudouet, François-Xavier

    2004-01-01

    Le vendredi 11 juin 2004 était annoncé le rachat par Accor des parts du groupe Agnelli et de la Caisse des Dépôts et Consignations (CDC) dans le Club Méditerranée (Club Med). Accor entrait ainsi à hauteur de 28,9 % dans le capital du Club Med, mettant ainsi fin à quelques trente années de compagnonnage entre la Famille Agnelli et le célèbre voyagiste français.[...]L’objet des présents développements est d’apporter un éclairage nouveau sur les conditions sous-jacentes du rapprochement, au trav...

  17. Vejbygning i områder med permafrost

    DEFF Research Database (Denmark)

    Jørgensen, Anders Stuhr

    2009-01-01

    Siden begyndelsen af 1990’erne er der registreret en markant stigning i den årlige middeltemperatur i Nunavik, Québec Canada. Dette har ført til en reduktion i udbredelsen af permafrost, hvilket truer stabiliteten af lufthavne og veje i området. I sommeren 2007 blev en teststrækning opført i...... Tasiujaq Lufthavn for at studere effekten af tre forskellige metoder, som skal være med til at reducere optøningen af permafrost under landingsbanen. De tre metoder, som er blevet undersøgt, er konvektionskøling (air convection embankment), varmeudtrækning (heat drain) samt et forsøg med ændring af...

  18. TeleMed: A distributed virtual patient record system

    Energy Technology Data Exchange (ETDEWEB)

    Forslund, D.W.; Phillips, R.L.; Kilman, D.G. [Los Alamos National Lab., NM (United States). Advanced Computing Lab.; Cook, J.L. [National Jewish Center for Immunology and Respiratory Medicine, Denver, CO (United States)

    1996-06-01

    TeleMed is a distributed diagnosis and analysis system, which permits physicians who are not collocated to consult on the status of a patient. The patient`s record is dynamically constructed from data that may reside at several sites but which can be quickly assembled for viewing by pointing to the patient`s name. Then, a graphical patient record appears, through which consulting physicians can retrieve textual and radiographic data with a single mouse click. TeleMed uses modern distributed object technology and emerging telecollaboration tools. The authors describe in this paper some of the motivation for this change, what they mean by a virtual patient record, and some results of some early implementations of a virtual patient record.

  19. Med 3. styrmand på Danmark-Ekspeditionen

    DEFF Research Database (Denmark)

    Trolles Legat har i samarbejde med Det grønlandske Selskab valgt at udgive en dagbog, der skildrer hverdagen gennem de to år. Det er 3. styrmand på ekspeditionsskibet ”Danmark” Christian Bendix Thostrups dagbøger, der tegner fine skildringer af det hårde liv i Nordøstgrønland fra en tid, hvor...... Nordøstgrønland. De er begge praktisk anlagt og har et overblik, der får stor betydning for ekspeditionen, da Mylius-Erichsens slædehold omkommer i Nordøstgrønland i 1907. Men inden da har Bendix sit hyr med at få tingene til at glide mellem den unge, ærekære skibschef Alf Trolle og den temperamentsfulde...

  20. Dimensionering af armerede betonbjælker med huller

    DEFF Research Database (Denmark)

    Hansen, Klavs Feilberg

    Rapporten beskriver brudmekanismen i armerede betonbjælker med huller, og på grundlag heraf angives dels metoder til dimensionering af ekstra armering ved huller der er så store at de griber ind i bjælkens normale måde at fungere på, dels kriterier for hvornår der blot skal placeres nogle få ekstra...

  1. The MEDiterranean SUpersite Volcanoes (MED-SUV) project

    Science.gov (United States)

    Puglisi, Giuseppe

    2014-05-01

    The MEDiterranean SUpersite Volcanoes (MED-SUV) project aims at gaining new insights in the knowledge of the processes on the base of the volcanic phenomena observable at the surface by using the broad inventory of multidisciplinary data available for Mt. Etna and Campi Flegrei/Vesuvius. These active volcanic areas, which have been here considered as a cluster of supersites, represent test cases since they embrace the main characteristics typical of both "opened- and closed-conduit" volcanic systems. For the purpose, MED-SUV objectives focus on the (i) development of novel monitoring instrumentations and data collection methods, (ii) implementation of the current observation infrastructures, (iii) better constraint of crucial volcanic parameters by integration of in-situ and satellite data, and (iv) the development of an e-infrastructure for data sharing. In this framework, MED-SUV is a great opportunity for scientific collaboration among diverse research institutions and industrial sectors. MED-SUV aims to use the achieved results to gain robust sets of multi-parametric observations using the most advanced analytic data processing techniques and volcanic process and hazard modelling methods. These will provide new insights in the current and past eruptive activity of the three test case volcanoes that will increase our technical-scientific ability of tracking volcanic-related hazards in the targeted areas, and of communicating with the proper decision-maker bodies. The implementation of an e-infrastructure compliant with EPOS and the other two supersite projects, MARsite and FUTUREVOLC, will contribute to the GEO/GEOSS interoperability principles and to the GEO 2012-15 work plan.

  2. Leitlinien-Suche jetzt auch bei MedPilot

    OpenAIRE

    Müller, W.

    2005-01-01

    MedPilot, die Virtuelle Fachbibliothek für Medizin (Suchzugriff auf eine umfangreiche Sammlung von Datenbanken) hat erneut Zuwachs erhalten. Das Spektrum der kostenfreien Recherchedatenbanken ist um den Zugriff auf die Leitlinien der Fachgesellschaften in der AWMF erweitert worden. Genutzt wird dazu die auf dem Universitäts-Rechenzentrum Düsseldorf installierte Suchmaschine des AWMF-Leitlinien-Informationssystems http://leitlinien.net.

  3. MED101: a laser-plasma simulation code. User guide

    International Nuclear Information System (INIS)

    Complete details for running the 1-D laser-plasma simulation code MED101 are given including: an explanation of the input parameters, instructions for running on the Rutherford Appleton Laboratory IBM, Atlas Centre Cray X-MP and DEC VAX, and information on three new graphics packages. The code, based on the existing MEDUSA code, is capable of simulating a wide range of laser-produced plasma experiments including the calculation of X-ray laser gain. (author)

  4. Ledelsesudvikling i ejerledede virksomheder med vækstambitioner

    DEFF Research Database (Denmark)

    Korsgaard, Steffen T.

    2006-01-01

    Dette bidrag beskriver konsulentvirksomheden Jonathan A/S' ledelsesudviklingsforløb 'Virksomheder i Vækst'. Forløbet henvender sig til ejerledere med vilje til og potentiale for vækst. Bidraget gør rede for Jonathan A/S' metoder og forudsætningerne for deres arbejde. Disse sættes løbende i relation...

  5. Typing av Legionella pneumophila med MALDI-TOF MS

    OpenAIRE

    Halgunset, Anders

    2012-01-01

    Legionella pneumophila er fakultativ intracellulære bakterier som lever naturlig i akvatiske habitater. De kan replikere i makrofager og protozoer, bli overført til mennesker gjennom areosoler og føre til smitte. Ved eventuelle utbrudd er det viktig å kunne identifisere kilden, noe som i dag bli gjort ved å typebestemme L. pneumophila med sekvensbasert typing (SBT). Samtidig har matrix-assisted laser desorption/ionization ? time-of-flight (MALDI?TOF) mass spectrometry...

  6. Hvad skal danske hospitaler med ungecaféer?

    DEFF Research Database (Denmark)

    Kvisgaard Knudsen, Kristina; Bregnballe, Vibeke

    forbedre unges oplevelse af at være indlagt, er der i Danmark etableret ungecaféer. Formål: At undersøge ungecaféers betydning for indlagte unge. Metode: Fire semistrukturerede interviews er foretaget med kronisk eller alvorligt syge unge i alderen 11-19 år. De unge har besøgt Café Nexus på Aarhus...

  7. Mitigation of Volcanic Risk: The COSMO-SkyMed Contribution

    Science.gov (United States)

    Sacco, Patrizia; Daraio, Maria Girolamo; Battagliere, Maria Libera; Coletta, Alessandro

    2015-05-01

    The Italian Space Agency (ASI) promotes Earth Observation (EO) applications related to themes such as the prediction, monitoring, management and mitigation of natural and anthropogenic hazards. The approach generally followed is the development and demonstration of prototype services, using currently available data from space missions, in particular the COSMO-SkyMed (Constellation of Small Satellites for Mediterranean basin observation) mission, which represents the largest Italian investment in Space System for EO and thanks to which Italy plays a key role worldwide. Projects funded by ASI provide the convergence of various national industry expertise, research and institutional reference users. In this context a significant example is represented by the ASI Pilot Projects, recently concluded, dealing with various thematic, such as volcanoes. In this paper a special focus will be addressed to the volcanic risk management and the contribution provided in this field by COSMO-SkyMed satellite constellation during the last years. A comprehensive overview of the various national and international projects using COSMO-SkyMed data for the volcanic risk mitigation will be given, highlighting the Italian contribution provided worldwide in this operational framework.

  8. Mars 2020 Entry, Descent and Landing Instrumentation 2 (MEDLI2)

    Science.gov (United States)

    Hwang, Helen H.; Bose, Deepak; White, Todd R.; Wright, Henry S.; Schoenenberger, Mark; Kuhl, Christopher A.; Trombetta, Dominic; Santos, Jose A.; Oishi, Tomomi; Karlgaard, Christopher D.; Mahzari, Milad; Pennington, Steven P.

    2016-01-01

    The Mars Entry Descent and Landing Instrumentation 2 (MEDLI2) sensor suite will measure aerodynamic, aerothermodynamic, and TPS performance during the atmospheric entry, descent, and landing phases of the Mars 2020 mission. The key objectives are to reduce design margin and prediction uncertainties for the aerothermal environments and aerodynamic database. For MEDLI2, the sensors are installed on both the heatshield and backshell, and include 7 pressure transducers, 17 thermal plugs, and 3 heat flux sensors (including a radiometer). These sensors will expand the set of measurements collected by the highly successful MEDLI suite, collecting supersonic pressure measurements on the forebody, a pressure measurement on the aftbody, direct heat flux measurements on the aftbody, a radiative heating measurement on the aftbody, and multiple near-surface thermal measurements on the thermal protection system (TPS) materials on both the forebody and aftbody. To meet the science objectives, supersonic pressure transducers and heat flux sensors are currently being developed and their qualification and calibration plans are presented. Finally, the reconstruction targets for data accuracy are presented, along with the planned methodologies for achieving the targets.

  9. Overview of the SkyMed/COSMO mission

    Science.gov (United States)

    Caltagirone, Francesco; Spera, Paolo; Vigliotti, R.; Manoni, Gemma

    1998-12-01

    The impact of natural and man-made disasters on the social and economic progress is going to become more significant, making necessary to consider natural disasters reduction. Therefore civil protection and resource managers need elements to make quicker and better decisions on a day-to-day basis, so giving the start to an emerging world-wide remote sensing market. A deep analysis on the potential users, mainly devoted to Mediterranean basin, highlights that existing and/or planned systems are not able to completely satisfy their requirements. To fulfill this gap, Italy decided to promote the SkyMed/COSMO system, presently financed by the Italian Space Agency. SkyMed/COSMO is a constellation of small satellites for observation, remote sensing and data exploitation for risks management and coastal zone monitoring, conceived to provide products, services and logistics to both institutional and commercial remote sensing users on global scale. Furthermore the system is able to satisfy a broad spectrum of important applications also in the field of the resource management, land use and law enforcement. The SkyMed/COSMO current system architecture foresees a constellation of small satellites in two different orbit planes composed by 4 satellite equipped with X-band SAR and 3 satellites equipped with optical sensors. The system is characterized by good spatial resolution, day and night/all-weather imaging capability and by a very good revisit time. The program, currently in phase B, is carried out by an industrial consortium lead by Alenia Aerospazio.

  10. Hyperbilirubinemi hos nyfødte – et kontroversielt tema. Erfaringer med nye indikasjoner for fototerapi og utskiftningstransfusjon

    Directory of Open Access Journals (Sweden)

    Alf Meberg

    2009-10-01

    Full Text Available  SAMMENDRAGNye indikasjoner for behandling av hyperbilirubinemi hos nyfødte (bilirubinskjema fra Hillingdon sykehus,England ble innført ved Vestfold sentralsykehus primo 1994. Endringene i panoramaet av behandlingstiltak(lysbehandling, utskiftningstransfusjon ble registrert i kohortene av levende fødte ved sykehuset i toårsperioden1994-95 og sammenlignet med foregående treårsperiode 1991-93. Total lysbehandlingsprevalens falt signifikantfra 6,9% av levende fødte i perioden 1991-93 til 5,5% i perioden 1994-95 (p betydelig fall i prevalensen av fullbårne barn som ble lysbehandlet for fysiologisk ikterus, fra 4,3% til 1,6% ihenholdsvis første og siste periode (p steg signifikant fra 2,0% av levende fødte til 3,2% (p økning i prematuritetsinsidensen, som steg fra 4,5% i perioden 1991-93 til 5,9% i perioden 1994-95 (p Andelen premature som ble lysbehandlet steg fra 45,2% i første til 53,1% i siste periode (p av blodgruppeimmuniserte barn som ble lysbehandlet var uforandret i de to periodene (henholdsvis 0,6% og0,7% (p > 0,05. Det var en markert reduksjon i prevalensen av barn som gjennomgikk utskiftningstransfusjon(fra 0,2 til 0,06% henholdsvis i de to periodene (p effekter av lysbehandling til friske fullbårne barn med ikterus, reduseres relativt betydelig med de moderatejusteringer av indikasjonene som er foretatt. Rutineskiftet har også betydd ressurssparing. På landsbasis vil en slikrutineendring medføre at 1000-2000 fullbårne barn hvert år kan unngå lysbehandling. Indikasjonene for fototerapiog utskiftningstransfusjon for hyperbilirubinemi hos nyfødte i Norge må diskuteres på nytt i lys av ny forskningmed tanke på nasjonal konsensus. Kortere liggetider for nyfødte i sykehus etter fødselen gjør det nødvendig medgode rutiner for oppfølging av hyperbilirubinemi utenfor sykehus.Meberg A. Hyperbilirubinemia – a controversial topic. Experiences with new guidelines for phototherapyand exchange transfusion . Nor J

  11. Crimean-Congo hemorrhagic fever infections reported by ProMED

    Directory of Open Access Journals (Sweden)

    Yavuz Ince

    2014-09-01

    Conclusions: Case reporting systems such as ProMED are useful to gather information and synthesize knowledge on the emerging infections. Although certain areas need to be improved, ProMED provided good information about Crimean-Congo hemorrhagic fever.

  12. Vejledning af og støtte til studerende med psykisk sårbarhed

    DEFF Research Database (Denmark)

    Grønkjær, Lene Gertsen

    2015-01-01

    Vejledning af og støtte til studerende med psykisk sår-barhed: Fremlæggelse af delresultater fra "Projekt vejledning af og støtte til studerende med psykisk sår-barhed". Delresultaterne har 2 foki: 1 med fokus på hvordan studerende med ADHD og depression beskriver deres læringsforudsætninger i kl...

  13. Kommunikation ved brug af mobile enheder med digital video i idræt

    DEFF Research Database (Denmark)

    Langagergaard Rødbro, Lise; Elbæk, Lars

    2012-01-01

    I artiklen redegøres kort for et projekt, som førte frem til en videoplatform, der er et bud på et ’lukket YouTube’, hvor video filmet med smartphone direkte kan uploades til, og med funktioner specifikt udviklet til skolens idrætsundervisning. Med afsæt i systemisk kommunikationsteori analyseres...

  14. Forskning i musikterapi - børn med en Autisme Spektrum Forstyrrelse

    DEFF Research Database (Denmark)

    Holck, Ulla

    2011-01-01

    Der er forskningsmæssig evidens for, at musikterapi med børn med en autisme spektrum forstyrrelse (ASF) har en signifikant effekt. Cochrane reviews påviser, at musikterapi fremmer verbal og navnlig nonverbal kommunikation hos børn med ASF. En RCT-undersøgelse viser endvidere en signifikant effekt...

  15. Patterns of 6-mercaptopurine and azathioprine maintenance therapy among a cohort of commercially insured individuals diagnosed with Crohn's disease in the United States

    Directory of Open Access Journals (Sweden)

    Lund JL

    2013-12-01

    Full Text Available Jennifer L Lund,1 Suzanne F Cook,2 Jeffery K Allen,2 Charlotte F Carroll,2 Michael D Kappelman3 1Department of Clinical Epidemiology, Aarhus University, Aarhus, Denmark; 2Worldwide Epidemiology, GlaxoSmithKline, Research Triangle Park, NC, USA; 3Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA Background and aims: Thiopurines, including 6-mercaptopurine (6-MP and azathioprine (AZA, are the mainstay of maintenance therapy for Crohn's disease (CD. However, studies examining their effectiveness in routine practice among diverse patient populations are lacking. Among a cohort of new users of 6MP/AZA, we described treatment patterns and changes in subsequent therapy. Methods: Using the Truven Health Analytics databases, we identified all individuals diagnosed with CD and initiating 6-MP/AZA monotherapy from 2001–2008 (n=3,657. We estimated the proportion of CD patients remaining on 6-MP/AZA monotherapy, using Kaplan–Meier methods, and identified predictors of treatment noncontinuation, using multivariable Cox regression. Among the “noncontinuers,” we described subsequent patterns of maintenance therapy and summarized the diagnosis and procedure codes and prescription drug claims preceding treatment discontinuation. Results: The 1-year 6-MP/AZA treatment continuation rate was 42%. Children (age ≤18 years and individuals with no prior anti-tumor necrosis factor (TNF use were more likely to continue 6-MP/AZA, while those dispensed more (>4 outpatient prescriptions for any drug before initiation of 6-MP/AZA were less likely to continue maintenance treatment. Overall, 1,128 (39% and 105 (4% individuals experienced a clinical event potentially indicating active disease or 6-MP/AZA-intolerance prior to discontinuation, respectively. Most patients discontinued therapy; among the remaining patients who failed to continue 6-MP/AZA, most augmented with an anti-TNF. Conclusion: Most patients initiating 6-MP

  16. PROSTORSKI RAZVOJ CELJA V OBDOBJU MED 1937-2011

    OpenAIRE

    Bratina, Andrej

    2016-01-01

    Diplomska naloga obravnava čas druge polovice dvajsetega stoletja, natančneje obdobje med leti 1937 in 2011. V tem času so na širitev mesta vplivali različni dejavniki, kot so: razvoj industrije, povečanje števila prebivalcev, gospodarski razvoj ter razvoj Celja kot upravnega, šolskega in kulturnega središča. Vsi ti dejavniki so povzročili nastanek novih industrijskih, bivalnih in rekreativnih površin. Prav tako so vplivali na razvoj cestnega in vodnega omrežja. Nastanek vseh teh novih površi...

  17. PRAVNA UREDITEV ODNOSOV MED NADZORNIM SVETOM IN REVIZIJSKO KOMISIJO

    OpenAIRE

    Obreza, Simon

    2012-01-01

    Upravljanje korporacij teorije razlagajo na različne načine. Njen obseg zajema poslovanje korporacije, obveznosti menedžerjev povezane z nadzorom uprave (poročanje, opravljanje revizije…). Bolj splošna definicija pa pravi, da je to zveza med različnimi udeleženci (delničarji, direktorji, delavci, upniki, itd.), ki vsi želijo začrtati smer poslovanja in njegovo izvajanje v korporaciji. Kar se tiče upravljanja družb, sta se glede na razmere v okolju, v katerem je nastala družba, razvila d...

  18. Konflikt med Rusijo in Ukrajino zaradi polotoka Krim

    OpenAIRE

    Juvan, Erik

    2016-01-01

    Za diplomsko delo sem si izbral zelo aktualno temo, in sicer konflikt med Rusijo in Ukrajino zaradi polotoka Krim. Tema je zanimiva, ker se veliko dogaja in je še vedno aktiven problem. Težav z literaturo nisem imel, saj je že na spletu ogromno podatkov. Moj prvi korak je bil nabrati ogromno virov iz različnih medijev, nato pa sem analiziral zgodovino tega območja in potek dogodkov na spornem območju. Prav tako pa sem raziskal, kako je na dogodke reagirala ena izmed največjih svetovnih organi...

  19. Quinoa - en afgrøde med potentiale

    OpenAIRE

    Blume, Steffen

    2009-01-01

    Med de nuværende afregningspriser på korn er det oplagt at kigge på andre afgrødearter, som ville kunne medføre et højere dækningsbidrag. Det er dog ikke så ligetil, idet afgrøder, der har potentiale for højere dækningsbidrag, som regel også medfører større risiko for fiasko. Dette gælder også quinoa.

  20. Celovit gospodarski in trgovinski sporazum med EU in Kanado (CETA)

    OpenAIRE

    Špur, Matic

    2016-01-01

    Diplomsko delo analizira Celovit gospodarski in trgovinski sporazum med EU in Kanado (CETA). Avtor najprej obravnava vzpostavitev območja proste trgovine z odpravo tarifnih postavk za blago. Pri tem se osredotoča, tako na industrijsko blago, s poudarkom na ribiški predelovalni in avtomobilski industriji, kot tudi na kmetijske izdelke. V okviru poglavja o blagu so predstavljena določila, ki se nanašajo na tehnične ovire trgovini, kot oblika necarinskih omejitev in na pravila izvora. V dipl...

  1. MED23: a new Mediator of H2B monoubiquitylation.

    Science.gov (United States)

    Streubel, Gundula; Bracken, Adrian P

    2015-12-01

    The Mediator multiprotein complex physically links transcription factors to RNA polymerase II and the basal transcription machinery. While the Mediator complex has been shown to be required for transcriptional initiation and elongation, the understanding of its interplay with histone modifying enzymes and post‐translational modifications remains elusive. In this issue of The EMBO Journal, Yao et al (2015) report that the MED23 subunit of the Mediator complex physically associates with the heterodimeric RNF20/40 E3‐ligase complex to facilitate the monoubiquitylation of histone H2B on gene bodies of actively transcribed genes. PMID:26438725

  2. Frequency of MED12 mutations in phyllodes tumors: Inverse correlation with histologic grade.

    Science.gov (United States)

    Yoon, Nara; Bae, Go Eun; Kang, So Young; Choi, Mi Sun; Hwang, Hye Won; Kim, Seok Won; Lee, Jeong Eon; Nam, Seok Jin; Gong, Gyungyub; Lee, Hee Jin; Bae, Young Kyung; Lee, Ahwon; Cho, Eun Yoon

    2016-06-01

    Phyllodes tumor (PT) is a rare breast biphasic tumor with a potential risk of recurrence and metastasis. In this study, the frequency of MED12 mutations in 176 PTs (49 benign, 49 borderline, and 78 malignant) was determined and the prognostic effect of these mutations in malignant type PT was evaluated. Analysis of MED12 mutations was performed by Sanger sequencing targeting the hotspot mutation region (exon 2) of MED12. Immunohistochemistry was also applied for evaluation of MED12 protein expression on tissue microarray blocks for 133 PTs including 50 benign, 50 borderline, and 33 malignant cases. A notable difference in the frequency of MED12 mutations was found according to histologic grade (71.4% of benign PTs, 51% of borderline PTs, 26.9% of malignant PTs; P expression was not correlated with MED12 mutation status. Patients with malignant PTs that harbored MED12 mutations demonstrated improved disease-free survival (DFS) compared with those without MED12 mutation (P = 0.07). MED12 mutation was a common molecular alteration in PT and the frequency of MED12 mutation decreased with increasing histologic grade. In malignant PT, MED12 exon 2 mutations showed improved DFS but without significance. © 2016 Wiley Periodicals, Inc. PMID:26856273

  3. MedCast: a discussion support system for cooperative work

    Science.gov (United States)

    Moreno, Ramon A.; Lima, Vinícius; Lopes, Isidro; Gutierrez, Marco A.

    2012-02-01

    The availability of low cost Internet connections and specialized hardware, like webcams and headsets, makes possible the development of solutions for remote collaborative work. These solutions can provide advantages compared to presential meetings, such as: availability of experts on remote locations; lower price compared to presential meetings; creation of online didactic material (e.g. video-classes); richer forms of interaction between participants. These technologies are particularly interesting for continent-sized countries where typically there is a short number of skilled people in remote areas. However, the application of these technologies in medical field represents a special challenge due to the more complex requirements of this area, such as: Provide confidentiality (patient de-identification) and integrity of patient data; Guarantee availability of the system; Guarantee authenticity of data and users; Provide simple and effective user interface; Be compliant with medical standards such as DICOM and HL7. In order to satisfy those requirements a prototype called MedCast is under development whose architecture allows the integration of the Hospital Information System (HIS) with a collaborative tool in compliance with the HIPAA rules. Some of the MedCast features are: videoconferencing, chat, recording of the sessions, sharing of documents and reports and still and dynamic images presentation. Its current version allows the remote discussion of clinical cases and the remote ECG evaluation.

  4. Fast ion extraction from the MedEBIS

    CERN Document Server

    Holtermann, H; Kleinod, M; Müller, I; 10.1088/1742-6596/2/1/012

    2004-01-01

    Cancer therapy synchrotrons profit from single turn injection in terms of size, costs and easy operation. The MEdically Dedicated EBIS (MedEBIS), built in Frankfurt, will deliver short (~1.5 mu s) and intense (~1.3 mA) pulses of highly charged light ions (C, N, O) to meet the requirements for therapy facilities. The MedEBIS operates with an electron beam of 400 mA at 5 keV and a ratio of beam to drift tube of 1/20. Drift tube potentials up to 1.6 kV are switched in some 100 ns to deliver a 1.5 mu s ion pulse at an axial field gradient of 6.5kV/m. On extraction, all potentials applied to the drift tubes are set to a given primary potential to define the extraction gradient. During extraction the drift tubes are not held at constant voltage to avoid spreading out of the pulse due to the restoration of the full space charge depression at locations where ions have already been extracted. To locally distribute the action of the applied potentials the drift tubes are fully interpenetrating each other with tapered f...

  5. MedAustron - Ion-Beam Therapy and Research Center

    International Nuclear Information System (INIS)

    MedAustron is a synchrotron-based light-ion beam therapy center for cancer treatment as well as for clinical and non-clinical research, currently in the commissioning phase in Wiener Neustadt, Austria. Recently, the first proton beam was transported successfully to one of the four irradiation rooms. Whilst the choice of basic machine parameters was driven by medical requirements, i.e. 60 MeV protons and 120 MeV/A to 400 MeV/A carbon ions, the accelerator complex design was also optimized to offer flexibility for research operation. The potential of the synchrotron is being exploited to increase the maximum proton energy far beyond the medical needs to up to 800 MeV, for experimental physics applications, mainly in the areas of proton scattering and detector research. The accelerator layout allows for the installation of up to four ion source-spectrometer units, to provide various ion types besides the clinical used protons and carbon ions. Besides experimental physics, the two main non-clinical research disciplines are medical radiation physics and radiation biology. To decouple research and medical operation, a dedicated irradiation room for non-clinical research was included providing the installation of different experiments. In addition, several labs have been equipped with appropriate devices for preparing and analyzing radio-biological samples. This presentation gives a status overview over the whole project and highlights the non-clinical research opportunities at MedAustron. (Author)

  6. Quince años de MedUNAB

    Directory of Open Access Journals (Sweden)

    Natalia Hérnandez Rey

    2013-08-01

    Full Text Available Para conmemorar los quince años de MedUNAB el comité estudiantil quiso escribir sobre el significado que tiene para cada uno de sus miembros pertenecer a ella. Es así como en este editorial recogemos las distintas experiencias que se han tenido, algunas de años, otras de meses. MedUNAB es una escuela editorial que hace posible que tres veces al año la comunidad académica de Latinoamérica cuente, tanto física como virtualmente, con una revista científica del área de la salud. Los miembros del comité estudiantil son seleccionados por el editor y por los integrantes con más antigüedad después de hacer un entrenamiento en el cual se aprenden las bases para el proceso editorial que va desde la recepción de los artículos, hasta cómo hacer llegar la revista a cada uno de ustedes en aulas de clase, congresos, simposios, charlas y consultorios, pasando por la evaluación de los escritos, basada en los estrictos parámetros internacionales, la búsqueda de revisores calificados, la corrección de estilo y la diagramación.

  7. Læringslandskaber for elever med indlæringsvanskeligheder

    DEFF Research Database (Denmark)

    Szulevicz, Thomas

    Baggrund Denne afhandling består af en empirisk undersøgelse af den pædagogiske praksis på Havredal Praktiske Landbrugsskole (HPL). HPL er en mesterlæreinspireret landbrugsuddannelse for unge elever mellem 16-25 år med indlæringsvanskeligheder. HPL fungerer som et moderne landbrug, der drives af...... elever og lærere i fællesskab. Der er 38 indskrevne elever på skolen, der dyrker 140 ha jord og har en besætning på 50 sortbrogede malkekøer i løsdriftsstald, 250 søer samt 10 heste. Elevernes uddannelse og læring er struktureret omkring deres deltagelse i landbrugsaktiviteterne på skolen. HPL er...... observationerne fandt sted i forskningsprojektets første 14 måneder. Herudover er der blevet foretaget kvalitative interviews med 12 elever fra HPL. Heraf blev de 7 af eleverne interviewet à 3 omgange. 7 lærere på HPL er blevet interviewet. Endelig er der blevet foretaget to videoobservationer af en elevs...

  8. Barn i familjer med missbruksproblem : En kvalitativ studie om daghemmets roll när ett barn kommer från en familj med missbruksproblem

    OpenAIRE

    Ålgars, Emma

    2010-01-01

    Ämnesområdet och temat för mitt arbete är barn i familjer med missbruksproblem. Syftet med min studie är att förstå vad det som barn innebär att leva i en familj med missbruksproblem och att se vilka konsekvenser det har för barnet. Jag vill även få reda på vad man på daghem kan göra för att stöda barn samt deras föräldrar i familjer med missbruksproblem. Mina tre frågeställningar för arbetet är; Hur ser barnets situation ut i en familj med missbruksproblem? Hur kan man på daghem identifiera ...

  9. Two Journeys and One University: King Christian I and Queen Dorothea's Journeys to Rome and the Foundation of the University of Copenhagen

    DEFF Research Database (Denmark)

    Jahnke, Carsten

    2014-01-01

    Behandler de omstændighederne omkring universitetsgrundlæggelsen og rydder op med den myte, at Københavns Universitet blev grundlagt af Christian I.......Behandler de omstændighederne omkring universitetsgrundlæggelsen og rydder op med den myte, at Københavns Universitet blev grundlagt af Christian I....

  10. Med5(Nut1 and Med17(Srb4 are direct targets of mediator histone H4 tail interactions.

    Directory of Open Access Journals (Sweden)

    Zhongle Liu

    Full Text Available The Mediator complex transmits activation signals from DNA bound transcription factors to the core transcription machinery. In addition to its canonical role in transcriptional activation, recent studies have demonstrated that S. cerevisiae Mediator can interact directly with nucleosomes, and their histone tails. Mutations in Mediator subunits have shown that Mediator and certain chromatin structures mutually impact each other structurally and functionally in vivo. We have taken a UV photo cross-linking approach to further delineate the molecular basis of Mediator chromatin interactions and help determine whether the impact of certain Mediator mutants on chromatin is direct. Specifically, by using histone tail peptides substituted with an amino acid analog that is a UV activatible crosslinker, we have identified specific subunits within Mediator that participate in histone tail interactions. Using Mediator purified from mutant yeast strains we have evaluated the impact of these subunits on histone tail binding. This analysis has identified the Med5 subunit of Mediator as a target for histone tail interactions and suggests that the previously observed effect of med5 mutations on telomeric heterochromatin and silencing is direct.

  11. A link between the cytoplasmic engulfment protein Elmo1 and the Mediator complex subunit Med31.

    Science.gov (United States)

    Mauldin, Joshua P; Lu, Mingjian; Das, Soumita; Park, Daeho; Ernst, Peter B; Ravichandran, Kodi S

    2013-01-21

    The cytoplasmic Elmo1:Dock180 complex acts as a guanine nucleotide exchange factor (GEF) for the small GTPase Rac and functions downstream of the phagocytic receptor BAI1 during apoptotic cell clearance, and in the entry of Salmonella and Shigella into cells. We discovered an unexpected binding between Elmo1 and the Mediator complex subunit Med31. The Mediator complex is a regulatory hub for nearly all gene transcription via RNA polymerase II, bridging the general transcription machinery with gene-specific regulatory proteins. Med31 is the smallest and the most evolutionarily conserved Mediator subunit, and knockout of Med31 results in embryonic lethality in mice; however, Med31 function in specific biological contexts is poorly understood. We observed that in primary macrophages, during Salmonella infection, Elmo1 and Med31 specifically affected expression of the cytokine genes Il10 and Il33 among the >25 genes monitored. Although endogenous Med31 is predominantly nuclear localized, Elmo1 increased the cytoplasmic localization of Med31. We identify ubiquitination as a novel posttranslational modification of Med31, with the cytoplasmic monoubiquitinated form of Med31 being enhanced by Elmo1. These data identify Elmo1 as a novel regulator of Med31, revealing a previously unrecognized link between cytoplasmic signaling proteins and the Mediator complex. PMID:23273896

  12. Novel de novo heterozygous loss-of-function variants in MED13L and further delineation of the MED13L haploinsufficiency syndrome.

    Science.gov (United States)

    Cafiero, Concetta; Marangi, Giuseppe; Orteschi, Daniela; Ali, Marwan; Asaro, Alessia; Ponzi, Emanuela; Moncada, Alice; Ricciardi, Stefania; Murdolo, Marina; Mancano, Giorgia; Contaldo, Ilaria; Leuzzi, Vincenzo; Battaglia, Domenica; Mercuri, Eugenio; Slavotinek, Anne M; Zollino, Marcella

    2015-11-01

    MED13L haploinsufficiency has recently been described as responsible for syndromic intellectual disability. We planned a search for causative gene variants in seven subjects with intellectual disability and overlapping dysmorphic facial features such as bulbous nasal tip, short mouth and straight eyebrows. We found two de novo frameshift variants in MED13L, consisting in single-nucleotide deletion (c.3765delC) and duplication (c.607dupT). A de novo nonsense variant (c.4420A>T) in MED13L was detected in a further subject in the course of routine whole-exome sequencing. By analyzing the clinical data of our patients along with those recently described in the literature, we confirm that there is a common, recognizable phenotype associated with MED13L haploinsufficiency, which includes intellectual disability and a distinctive facial appearance. Congenital heart diseases are found in some subjects with various degree of severity. Our observation of cleft palate, ataxia, epilepsy and childhood leukemia observed in single cases broadens the known clinical spectrum. Haploinsufficiency for MED13L should be considered in the differential diagnosis of the 1p36 microdeletion syndrome, due to overlapping dysmorphic facial features in some patients. The introduction of massive parallel-sequencing techniques into clinical practice is expected to allow for detection of other causative point variants in MED13L. Analysis of genomic data in connection with deep clinical evaluation of patients could elucidate genetic heterogeneity of the MED13L haploinsufficiency phenotype. PMID:25712080

  13. Kontinuerlig positionsbestämning med multipla kameror

    OpenAIRE

    Karlsson, Linda

    2010-01-01

    Arbetets syfte var att forska i möjligheten att utveckla ett positionsbestämningssystem för tävlande hästar på en travbana genom att använda de kameror som redan är i användning där för bedömning av loppen. Arbetet utgår från de förhållanden som gäller på Vermo travbana i Helsingfors. Frågeställnigen var om det är möjligt att bestämma positionen i världskoordinater för ett föremål med hastigheten 16 m/s tillräckligt snabbt och noggrant för att uppfylla krav på kontinuerlighet och realtid unde...

  14. Att bemöta kvinnor med anorexia nervosa

    OpenAIRE

    Erlandsson, Christian; Heiler, Linnéa; Henningsson, Sofie

    2005-01-01

    Studiens syfte har varit att se vad kvinnor med anorexia har för behov av och hur de upplever närståendes/vårdares omtanke och omsorg, och hur dessa ser på kvinnornas behov. Studien är en litteraturstudie där tre skönlitterära böcker som följer tre kvinnor drabbade av anorexia granskats. I bakgrunden framkommer att enligt Världshälsoorganisationen har skolbarnens hälsovanor förandrats sedan 1980-talet, då framförallt hos flickor. Idealvikten har blivit lägre och skönhetsidealen står i fokus h...

  15. BULLYING MED UČENCI OSNOVNE ŠOLE

    OpenAIRE

    Klein, Nastja

    2014-01-01

    Pri nasilju gre za naučen vedenjski vzorec, ki je nedopusten in kazniv. Gre za širok spekter negativnih ravnanj, ki pri žrtvah puščajo hude in dolgotrajne tako čustvene in fizične posledice. Otrok, ki je žrtev takšnega nasilja, lahko ima trajne posledice in je zaznamovan za vse življenje. Povzročitelj nasilja je za to odgovoren, žrtvi pa se nudi takojšnja pomoč. Strokovna literatura v grobem loči pet vrst nasilja: psihično, fizično, medvrstniško, spolno in nasilje v družini. Nasilje med v...

  16. SPLETNO NASILJE MED DIJAKI SREDNJIH ŠOL

    OpenAIRE

    Mezgec, Maja

    2015-01-01

    Zgodovina nas uči, da je nasilje prisotno med nami odkar pomnimo. Nenasilen pristop k reševanju konfliktov je za človeštvo dokaj nov, saj se je začel globalno uveljavljati po koncu 2. svetovne vojne z ustanovitvijo OZN. Vendar pa je za uveljavitev tako velikih ideoloških sprememb ter navad na globalnem nivoju potreben čas. Tako je bilo za generacije naših staršev popolnoma samoumevno izvajanje nasilja nad učenci s strani učiteljev. Pretirane pozornosti se ni posvečalo tudi fizičnemu obračunav...

  17. Peer til peer i arbejdet med udsatte mennesker

    DEFF Research Database (Denmark)

    Dindler, Camilla; Ahlmark, Nanna; Norrhäll, Oskar;

    mænd i risiko for at udvikle type 2 diabetes. En del af evalueringsopdraget har været at tilvejebringe viden om relevant litteratur om peer-metoder. I denne forbindelse er dette notat udarbejdet til Københavns Kommunes Forebyggelsescenter Nørrebro af evaluerings-teamet, som består af forsker, Nanna......Statens Institut for Folkesundhed, Syddansk Universitet har fået til opdrag at lave en formativ procesevaluering af Københavns Kommunes projekt Mænd i København. Projektet omhandler udvikling og implementering af en peer til peer indsats med henblik på at forbedre sundhed og trivsel blandt udsatte...... Ahlmark, adjunkt ved Aalborg Universitet Camilla Dindler, praktikant og specialestuderende Oskar Norrhäll og specialestuderende Pernille Hartvig Jensen. Notatet er en sammenfatning af udvalgt forskningslitteratur og rapporter om peer til peer-relaterede projekter målrettet udsatte grupper i forbindelse...

  18. Overview of the MedAustron design and technology choices

    CERN Document Server

    Benedikt, M; Palm, M; Pirkl, W; Dorda, U; Fabich, A

    2010-01-01

    MedAustron is a synchrotron based accelerator facility for cancer treatment in Austria currently in the development phase. The design is based on the PIMMS study [1] and CNAO [2] synchrotron. In addition to the clinical application, the accelerator will also provide beams for nonclinical research in the fields of medical radiation physics, radiation biology and experimental physics with an extended proton energy range beyond medical requirements to 800 MeV. The differences to others medical acceleratorbased facilities will be elaborated, specifically the used source technologies and configuration (starting up with protons (p) and carbon ions (C6+) allowing a later upgrade to ion species up to neon) and the online verification of all relevant beam parameters. The current project status is presented.

  19. Økolandsby med naturbasert avløpsrensing

    OpenAIRE

    Arnardóttir, Hildur Dabjört

    2013-01-01

    Vi lever i et forbrukersamfunn og vår levemåte kan ikke kalles for bærekraftig. Det er grenser for hvor lenge vi kan fortsette på denne måten. Samfunnet og omgivelsene må planlegges med det som hovedfokus å gjøre det lettere for folk å leve på en bærekraftig måte. I denne mastersoppgaven planlegger jeg en økolandsby på Gjernes i Risør kommune fra grunnen av, hvor det tilrettelegges for bærekraftig livstil. Gjennom litteratursøk, analyser, idealistiske ideer og løsninger og planlegging a...

  20. Mars Science Laboratory (MSL) Entry, Descent, and Landing Instrumentation (MEDLI): Complete Flight Data Set

    Science.gov (United States)

    Cheatwood, F. McNeil; Bose, Deepak; Karlgaard, Christopher D.; Kuhl, Christopher A.; Santos, Jose A.; Wright, Michael J.

    2014-01-01

    The Mars Science Laboratory (MSL) entry vehicle (EV) successfully entered the Mars atmosphere and landed the Curiosity rover safely on the surface of the planet in Gale crater on August 6, 2012. MSL carried the MSL Entry, Descent, and Landing (EDL) Instrumentation (MEDLI). MEDLI delivered the first in-depth understanding of the Mars entry environments and the response of the entry vehicle to those environments. MEDLI was comprised of three major subsystems: the Mars Entry Atmospheric Data System (MEADS), the MEDLI Integrated Sensor Plugs (MISP), and the Sensor Support Electronics (SSE). Ultimately, the entire MEDLI sensor suite consisting of both MEADS and MISP provided measurements that were used for trajectory reconstruction and engineering validation of aerodynamic, atmospheric, and thermal protection system (TPS) models in addition to Earth-based systems testing procedures. This report contains in-depth hardware descriptions, performance evaluation, and data information of the three MEDLI subsystems.