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Sample records for behandling af patienter

  1. Behandling af den hypoterme patient

    DEFF Research Database (Denmark)

    Kjærgaard, Benedict; Rudolph, Søren Finnemann; Lucas, Alexander

    2008-01-01

    Treatment of the hypothermic patient depends more on the clinical condition than on the core temperature. Unconscious patients need thorough investigation, and they can often be rewarmed with warm water in the pleural cavities. Cardiac arrest requires cardio pulmonary rescue until rewarming can...

  2. Choledocholitiasis. Endoskopisk behandling af 416 konsekutive patienter

    DEFF Research Database (Denmark)

    Pedersen, F M; Brandt, C J; Schaffalitzky de Muckadell, O B

    1998-01-01

    patients who underwent ERC for common bile duct stones between January 1990 and January 1995. The overall success rate of achieving a common bile duct free of stones was 89.0%, and in 94.7% of the patients endoscopic treatment was definitive. The overall complication rate was 9.6% and the 30-day mortality...

  3. Tværsektorielt samarbejde ved behandling af patienter med type 2-diabetes

    DEFF Research Database (Denmark)

    Munch, Lene; Røder, Michael E; Hansen, Ida H

    2018-01-01

    Hovedbudskaber • Sundhedsstyrelsen lægger vægt på tværsektorielt samarbejde omkring patienten med type 2-diabetes, men denne tankegang er dog ikke implementeret i det danske sundhedsvæsen • På organisatorisk niveau kan en stratificerings- og forløbsmodel give anvisninger til opgave- og...... udnyttelse af sundhedsvæsenets ressourcer samtidig med, at behandling af høj kvalitet fastholdes og udvikles for patienter med type 2-diabetes...

  4. Behandling af misbrugere med tilbagefald

    DEFF Research Database (Denmark)

    Sørensen, Johanne Korsdal

    igen er på stoffer og ønsker et nyt behandlingforløb. Tilbagefaldsbehandlingen består af 14 dages afgiftning på Kongens Ø, derefter seks ugers Gorski behandling på Knogens Ø, hvor der er fokus på tilbagefaldsproblematikken. Derefter kommer klienterne tilbage til Esbjerg, hvor de starter i...

  5. Enkeltcenteropgorelse af nyretransplanterede patienters nyrefunktion og immunsuppressive behandling

    DEFF Research Database (Denmark)

    Frederiksen, A.M.; Ewers, B.; Gasbjerg, A.

    2008-01-01

    INTRODUCTION: The number of kidney-transplanted patients is growing. This report describes the age, sex distribution, kidney function, graft age, and immunosuppressive drugs of kidney-transplanted patients followed at the outpatient clinic of the nephrology department at Copenhagen University...... (131 males, 110 females) was equal. The average patient age was 52 years (SD 12), the average glomerular filtration rate 43 ml/min/1.73 m2 (range 6-114 ml/min/1.73 m2), and the average graft age was 8.3 years (range 0-28 years). Hyperparathyroidism was highly prevalent (64%). The majority of patients...

  6. Behandling af kroniske sygdomme hos patienter med demens

    DEFF Research Database (Denmark)

    Pedersen, Hanne; Klinkby, Kristian Skikkild; Waldorff, Frans Borch

    2017-01-01

    Comorbidity is common in patients with dementia, and due to the nature of the dementia disease, patients with dementia have special challenges in relation to comorbidity. This article is about dementia and heart failure, chronic obstructive pulmonary disease, urinary incontinence, falls...

  7. Karakteristik, diagnostik og behandling af patienter med autoimmun hepatitis

    DEFF Research Database (Denmark)

    Ytting, Henriette; Larsen, Fin Stolze

    2012-01-01

    Autoimmune hepatitis is a relatively rare disease that may lead to rapidly progressing liver cirrhosis and even fulminant liver failure, if diagnosis and treatment is delayed or ineffective. Diagnosing the disease can be challenging, and one in five patients respond insufficiently to standard...... treatment. Patients, who are diagnosed late in the disease course or only respond partly to medical treatment, are at high risk of developing severe liver insufficiency. This article summarizes the present knowledge and evidence regarding diagnostics, therapy and disease course....

  8. Endoskopi af patienter i antitrombotisk og antikoagulerende behandling

    DEFF Research Database (Denmark)

    Kjeldsen, Jens; Kjærulf Pless, Torsten; Meisner, Søren

    2009-01-01

    Drugs that interfere with haemostasis are widely used for thromboembolic diseases and cardiovascular protection. Gastrointestinal bleeding is a well-known complication, and endoscopists are often faced with decisions concerning the safety of endoscopic procedures in these patients. Based on exper...

  9. Medicinsk behandling af patienter med primær hyperparathyroidisme

    DEFF Research Database (Denmark)

    Vestergaard, Peter; Mosekilde, Leif

    2009-01-01

    Surgery is the recommended treatment for primary hyperparathyroidism. For exceptional medical treatment, the main drugs available are cinacalcet to normalize plasma calcium, and bisphosphonates to prevent bone loss. The patients eligible for medical therapy are those who cannot be operated or whose...

  10. Palliativ behandling af patienter med terminal kronisk obstruktiv lungesygdom

    DEFF Research Database (Denmark)

    von Plessen, Christian; Nielsen, Thyge L; Steffensen, Ida E

    2011-01-01

    Terminal chronic obstructive pulmonary disease (COPD) and advanced cancer have similar prognosis and symptom burden. However, palliative care of patients with terminal COPD has been neglected in Denmark. We describe the symptoms of terminal COPD and suggest criteria for defining the palliative ph...

  11. Bivirkninger ved N-acetylcystein-behandling af paracetamolforgiftede patienter

    DEFF Research Database (Denmark)

    Schmidt, L E; Dalhoff, K P

    1999-01-01

    Treatment of paracetamol intoxication with N-acetylcysteine (NAC) is standard in Denmark. NAC is considered safe with relatively few side effects. It is recommended that all patients be treated irrespective of paracetamol dose or time from intoxication to treatment start. Consequently a higher nu...

  12. Gruppebaseret behandling af BED - et faseopdelt behandlingstilbud

    DEFF Research Database (Denmark)

    Laust, Jakob; Lau, Marianne Engelbrecht; Waaddegaard, Mette

    2015-01-01

    Titel: Afrapportering vedr. SATS-puljemidler til behandling og erfaringsopsamling vedr. BED for perioden 1. marts 2013 – 1. maj 2015. Baggrund: Binge Eating Disorder (BED), på dansk tvangsoverspisning, er en udbredt, men overset spiseforstyrrelse med alvorlige psykiske, fysiske og sociale...... konsekvenser. BED blev i 2013 optaget i DSM-5 (Diagnostic and Statistical Manual of Mental Disorders) som en selvstændig diagnose og BED forventes medtaget i den forestående revision af det internationale diagnose system, ICD-11. Sundhedsstyrelsen gav på denne baggrund satspuljemidler til erfaringsopsamling...... vedr. BED. I den forbindelse ansøgte Ambulatorium for Spiseforstyrrelser på Psykoterapeutisk Center Stolpegård ovenstående midler til at udvikle en ambulant, primært psykoterapeutisk gruppebehandling til patienter med moderat til svær BED med fokus på såvel spiseforstyrrelse såvel som overvægt. Metode...

  13. Organisation af behandling og opfølgning af patienter med type 2-diabetes

    DEFF Research Database (Denmark)

    Drivsholm, Thomas Bo; Snorgaard, Ole

    2012-01-01

    The organization of treatment and control of type 2 diabetic patients in Denmark has undergone a major development within the last decade. From being based on local hospital guidelines, treatment and control have moved towards a more organized collaboration between primary and secondary care based...... on common national guidelines. Quality indicators from primary and secondary care are collected routinely, and gradually an increasingly precise depiction is documented in the National Indicator Project....

  14. Fysisk rehabilitering i forbindelse med behandling af hæmatologiske sygdomme

    DEFF Research Database (Denmark)

    Høgdal, Nina; Bartels, Frederik Reith; Smith, Nicholas Simon

    2015-01-01

    I denne statusartikel vurderes det, hvorvidt det eksisterende fysioterapeutiske træningstilbud under behandling af maligne sygdomme med højdosis kemoterapi og perifer stamcellestøtte (HD-ASCT) lever op til anbefalingerne i Kræftplan III. Alle seks hospitaler i Danmark, som behandler patienter med...

  15. Eksperimentel bakteriofagterapi til behandling af kronisk Pseudomonas aeruginosaotitis hos hund

    DEFF Research Database (Denmark)

    Moodley, Arshnee; Mølgaard, Jesper

    2016-01-01

    Vi beskriver en case med anvendelsen af bakteriofager til behandling af kronisk otitis forårsaget af multiresistente Pseudomonas aeruginosa som en sidste behandlingsmulighed før aflivning. Trods gentagne behandlinger, både topikalt og systemisk, med op til seks forskellige antibiotika over en...

  16. Orale senfølger af behandling for hoved-halscancer

    DEFF Research Database (Denmark)

    Assaad, Hala; Dynesen, Anja Weirsøe; Thisted, Lise Bjerrum

    2014-01-01

    Forebyggelse af orale senfølger af behandling for hoved-hals-cancer er vigtig for orale funktioner og livskvalitet Patienter, der er strålebehandlet for hovedhals-cancer, oplever betydelige senfølger i mundhulen; herunder xerostomi og hyposalivation, oral candidose, ubehag og smerte fra...... orale senfølger....

  17. Behandling af hydatidose med albendazol

    DEFF Research Database (Denmark)

    Magnussen, P; Gelletlie, R; Bygbjerg, Ib Christian

    1989-01-01

    Eight patients with hydatidosis treated with albendazol in daily doses of 10 mg/kg daily in courses of 28 days (4-6 courses) were analysed. The patients came from Morocco, Spain, Turkey and Yugoslavia. Seven patients had a cyst (or cysts) in the liver and one had also cysts in the kidneys. One...

  18. stausartikel: behandling af subcutane abscesser

    DEFF Research Database (Denmark)

    Hardgrib, Nina; Petersen, Klaus Kjær

    2017-01-01

    be administered, and the cavity should be closed without dead space. Antibiotics should not routinely be given, but always be considered in immunocompromised patients or patients with septicaemia. Routine examination of the microbiology has no influence on the treatment and is not recommended.......Simple subcutaneous abscesses are common, and we have examined the literature concerning the ideal treatment of subcutaneous abscesses. We recommend radical debridement with removal of all pus, the abscess wall and any necrosis. If primary suture is chosen, preoperative antibiotics should...

  19. Kirurgisk behandling af cancer pancreatis

    DEFF Research Database (Denmark)

    Bergenfeldt, Magnus; Hansen, Carsten Palnaes; Mortensen, Michael Bau

    2010-01-01

    Surgery remains the only hope for cure in pancreatic cancer. The most common procedures are reviewed. Postoperative morbidity and mortality below 30% and 5%, respectively, are the standard. The benefit of extended lymph node dissection and portal-mesenteric vein resection is dubious. Selected...... patients with locally advanced cancer may be down-staged with chemo-radiotherapy and eventually resected. Endoscopic stent placement is the preferred method to relieve biliary and/or gastrointestinal obstruction. The outcome is better for patients treated at high-volume centres than at smaller hospitals....

  20. Kirurgisk behandling af lumbal diskusprolaps

    DEFF Research Database (Denmark)

    Støttrup, Christian; Andresen, Andreas K; Ernst, Carsten

    2018-01-01

    The Danish Health Authority has recently published a new guideline on the treatment of lumbar disc herniation with radiculopathy. This paper goes through the surgical treatment and considers the evidence behind surgical treatment of these patients, along with the outcome reported in literature...

  1. Rekommandation for behandling af paracetamolforgiftning

    DEFF Research Database (Denmark)

    Clemmesen, J O; Ott, P; Dalhoff, K P

    1996-01-01

    Based on recent reports concerning the efficacy of N-acetylcysteine (NAC) in paracetamol (acetaminophen) poisoning, guidelines for treatment and control of these patients are reviewed by a study group under the Danish Association for the Study of the Liver. It is recommended that NAC-treatment is...

  2. Onkologisk behandling af meningeal carcinomatose

    DEFF Research Database (Denmark)

    Sulim, S.; Høyer, Morten

    2005-01-01

    Meningeal carcinomatosis (MC) occurs in 5-8% of cancer patients. In the       majority of cases, MC appears in patients with advanced disease. The       increase in incidence is probably caused by improved survival due to       improvements in systemic therapy and an increased awareness of MC among......       clinicians. Diagnosis is based on CSF cytology and neuroimaging. MC is a       devastating condition that is associated with a poor prognosis, with a       median survival time of 4-11 weeks. The treatment is in most cases       palliative and involves radiotherapy and/or chemotherapy...

  3. Udredning og behandling af reflekssynkoper

    DEFF Research Database (Denmark)

    Mehlsen, Jesper; Mehlsen, Anne-Birgitte

    2008-01-01

    Syncope is associated with considerable costs to society as well as to the patient. Syncope may arise on a neurological, cardiac, or neurovascular background. Cardiac and neurological causes are evaluated by standard methods. Neurovascular syncope is diagnosed by tilt table testing and carotid ma...... massage. The treatment of neurological or cardiac syncope aims at the underlying cause, whereas the treatment of neurovascular syncope consists of information and instruction in reasonable precautions. In persisting cases, medical treatment or pacemaker implantation may be necessary....

  4. Diagnostik og behandling af fenylketonuri

    DEFF Research Database (Denmark)

    Bayat, Allan; Møller, Lisbeth Birk; Lund, Allan Meldgaard

    2015-01-01

    Primary phenylalanine hydroxylase deficiency, also known as phenylketonuria, results in accumulation of phenylalanine in the blood. Early identification and treatment prevents the majority of clinical sequelae to the disease, but psychological and neurodevelopmental problems can occur in some...... patients. This article reviews the symptoms, diagnosis, classification and strategies of treatment and management of phenylketonuria. Finally we review new pharmacological and non-pharmaco-logical means of treatment....

  5. Udredning og behandling af reflekssynkoper

    DEFF Research Database (Denmark)

    Mehlsen, Jesper; Mehlsen, Anne-Birgitte

    2008-01-01

    Syncope is associated with considerable costs to society as well as to the patient. Syncope may arise on a neurological, cardiac, or neurovascular background. Cardiac and neurological causes are evaluated by standard methods. Neurovascular syncope is diagnosed by tilt table testing and carotid...... massage. The treatment of neurological or cardiac syncope aims at the underlying cause, whereas the treatment of neurovascular syncope consists of information and instruction in reasonable precautions. In persisting cases, medical treatment or pacemaker implantation may be necessary....

  6. Diagnose og behandling af binyrebarkkarcinom

    DEFF Research Database (Denmark)

    Abildgaard, Julie; Pappot, Helle; Petersen, Peter Meidahl

    2013-01-01

    Adrenocortical carcinomas (ACC) are rare tumours responsible for only 0.02% of the total number of malignant diseases. However the ACC are aggressive with a mean fiveyears survival of 20-50% and are often associated with increased production of adrenocortical hormones. The effect of the treatment...... is controversial and often based on small retrospective series or expert opinions. Centralization, international attention and collaboration in the treatment of ACC are mandatory. Randomized clinical trials are needed to determine the best treatment strategy in order to increase survival in patients with ACC....

  7. Udredning og behandling af hoste

    DEFF Research Database (Denmark)

    Laursen, Lars Christian

    2013-01-01

    Cough is frequently a reason for seeing a doctor. Cough has a wide range of causes and the diagnosis can be difficult to make. Cough is often benign and self-limiting but can also be the first sign of malignancy. Especially chronic cough reduces the patients' quality of life. The purpose...... of this review was to present the most common reasons for cough, a rational method of investigation and a management protocol. Cough is a condition, which in most cases can be treated when using a systematic approach....

  8. Skattemæssig behandling af virtuelle valutaer

    DEFF Research Database (Denmark)

    Kjærsgaard, Louise Fjord; Weber, Katja Dyppel

    2018-01-01

    Udbredelsen og anvendelsen af virtuelle valutaer er stigende, og der synes derfor behov for en analyse af den skattemæssige kvalifikation og behandling heraf. Skatterådet har ved to lejligheder haft mulighed for at foretage denne analyse; i henholdsvis SKM2014.226.SR om Bitcoins og SKM2017.520.SR...

  9. Behandling af digital dermatitis på KFC

    DEFF Research Database (Denmark)

    Krogh, Kenneth; Thomsen, Peter

    2008-01-01

    På Kvægbrugets Forsøgscenter blev de rutinemæssige klovbade i maj 2007 erstattet med månedlige tjek af klove i beskærerboks og behandling af klovlidelser, herunder især Digital Dermatitis. Behandlingseffekten har været høj med 90 % helbredte efter en måned. Udgivelsesdato: april 2008......På Kvægbrugets Forsøgscenter blev de rutinemæssige klovbade i maj 2007 erstattet med månedlige tjek af klove i beskærerboks og behandling af klovlidelser, herunder især Digital Dermatitis. Behandlingseffekten har været høj med 90 % helbredte efter en måned. Udgivelsesdato: april 2008...

  10. Udredning og behandling af osteoporose hos patienter med kronisk obstruktiv lungesygdom

    DEFF Research Database (Denmark)

    Eiken, Pia Agnete; Brask-Lindemann, Dorte; Vestbo, Jørgen

    2012-01-01

    Patients with chronic obstructive pulmonary disease have a high risk of osteoporosis and fractures. We present an algorithm for the prevention and treatment of osteoporosis in patients with chronic obstructive pulmonary disease....

  11. Behandling af højt blodtryk hos patienter med akut apopleksi

    DEFF Research Database (Denmark)

    Olsen, T S; Jørgensen, H S; Garde, E

    1995-01-01

    The study was performed to investigate how often reduction of high blood pressure (> or = 220 mmHg systolic and or > or = 120 mmHg diastolic) was attempted in patients with acute stroke or transient ischemic attacks (TIA). Of 1351 consecutive patients with acute stroke or TIA 119 had high blood...... encephalopathy. It is concluded that reduction of high blood pressure in patients with stroke or TIA is attempted too often. As autoregulation is commonly impaired in acute stroke, reduction of systemic blood pressure may enhance ischaemic tissue damage. Reduction of blood pressure in acute stroke should...... pressure on admission. In 15 patients the stroke was so severe that treatment was not considered. In the remaining 104 patients reduction of the blood pressure was attempted in 28 (27%); in 23 patients immediately following admission. None of the patients had symptoms or signs of hypertensive...

  12. Enkeltcenteropgørelse af nyretransplanterede patienters nyrefunktion og immunsuppressive behandling

    DEFF Research Database (Denmark)

    Frederiksen, Anne Mette; Hansen, Jesper Melchior; Ewers, Bettina

    2008-01-01

    (131 males, 110 females) was equal. The average patient age was 52 years (SD 12), the average glomerular filtration rate 43 ml/min/1.73 m2 (range 6-114 ml/min/1.73 m2), and the average graft age was 8.3 years (range 0-28 years). Hyperparathyroidism was highly prevalent (64%). The majority of patients...... with a functioning graft have sufficient kidney function to keep the patients free of uremic symptoms. Hyperparathyroidism is frequent. The immunosuppressive regimens used for kidney-transplanted patients are currently changing....

  13. Toksoplasmose-chorioretinitis: klinisk forløb og behandling af syv patienter

    DEFF Research Database (Denmark)

    Lebech, A M; Lebech, M; Børme, K K

    1996-01-01

    Toxoplasmosis is a major and preventable cause of severe visual loss and blindness in young people. Ocular toxoplasmosis is the leading cause of posterior uveitis and in most cases it represents a late manifestation of a congenital infection. The clinical picture and anti-Toxoplasma therapy...... of seven patients referred to the Department of Infectious Diseases, Hvidovre Hospital is described. All patients had clinical ocular toxoplasmosis at initial examination with unilateral focal necrotizing retinitis associated with typical old, pigmented scars. All patients had anti-toxoplasmosis Ig......G antibodies. After anti-Toxoplasma therapy with sulfadiazine, pyrimethamine and corticosteroid the ocular lesions were healed to atrophic scars and the inflammatory activity disappeared. We conclude that when the clinical picture is compatible with toxoplasmosis, antibodies to Toxoplasma gondii...

  14. Udredning og behandling af osteoporose hos patienter med prostatacancer uden knoglemetastaser

    DEFF Research Database (Denmark)

    Eiken, Pia A; Langdahl, Bente Lomholt; Eiken, Frederik L

    2011-01-01

    The prevention of cancer treatment-induced bone loss in patients with prostate cancer due to gonadotropin-releasing hormone (GnRH)-agonist, GnRH-antagonist and orchidectomi therapy has a high priority. We present an algorithm for the prevention and treatment of osteoporosis during treatment of non...

  15. Udredning og behandling af osteoporose hos patienter med prostatacancer uden knoglemetastaser

    DEFF Research Database (Denmark)

    Eiken, Pia Agnete; Langdahl, Bente Lomholt; Eiken, Frederik L

    2011-01-01

    The prevention of cancer treatment-induced bone loss in patients with prostate cancer due to gonadotropin-releasing hormone (GnRH)-agonist, GnRH-antagonist and orchidectomi therapy has a high priority. We present an algorithm for the prevention and treatment of osteoporosis during treatment of no...

  16. Medicinsk behandling af osteoporose hos patienter med moderat til svaert nedsat nyrefunktion

    DEFF Research Database (Denmark)

    Eiken, Pia A; Vestergaard, Peter

    2012-01-01

    Both chronic kidney disease and osteoporosis are frequent conditions in the general population. Most drugs for treating osteoporosis seem safe in terms of affecting renal function for patients with mildly to moderate decreased renal function. There are very few data on the efficacy (reduction in ...

  17. Behandling af svær anæmi hos patienter, der afviser blodtransfusion

    DEFF Research Database (Denmark)

    Lorentzen, Kristian; Kjær, Bjarne Nordstrøm; Olsen, Karsten Skovgaard

    2014-01-01

    In situations involving serious bleeding and anaemia, a refusal of blood transfusion puts the clinician in an ethical and medical dilemma, as standard treatment is not an option, and the patient risks dying of a potentially reversible cause. This status article describes methods of treatment under...

  18. Dobbeltballonendoskopi til diagnostik og behandling af sygdomme i tyndtarmen. De forste danske erfaringer fra 31 patienter

    DEFF Research Database (Denmark)

    Jensen, T.M.; Vilmann, P.; Hendel, J.W.

    2008-01-01

    2004 to September 2006. RESULTS: A total of 42 DBE (32 oral, ten anal) were performed. Insertion-length for the oral and anal DBE was 206 cm (range 40-500 cm) beyond the Ligament of Treitz and 141 cm (range 10-200 cm) beyond the ileo-cecal valve, respectively. Duration was 128 min/124 min (range 55......-285 min/60-155 min), respectively. In two patients a total inspection of the small bowel was possible. The diagnostic yield was 74% (CI: 57%-86%) with a therapeutic yield in 21 patients (68% CI: 50%-81%). One major complication with perforation occurred due to improper handling of the endoscope....... CONCLUSION: DBE is a new effective method for the diagnosis and treatment of small bowel diseases. If used correctly, DBE is safe with few complications. DBE is expected to become an essential endoscopic method for handling small bowel diseases in close conjunction with capsule endoscopy. DBE demands...

  19. Organtransplanterede patienter har behov for intensiv kontrol og behandling af hudcancer

    DEFF Research Database (Denmark)

    Togsverd-Bo, Katrine; Sørensen, Søren Schwartz; Hædersdal, Merete

    2013-01-01

    The risk of non-melanoma skin cancer (NMSC) and in particular squamous cell carcinoma is significantly increased in organ transplant recipients due to long-term treatment with immunosuppressives. Dermatologic management in the form of a multidisciplinary approach, including patient education, skin...... surveillance and early treatment of premalignant and malignant lesions is recommended. Field-directed rather than lesional therapy is preferred for actinic keratosis in field-cancerized skin; and high-efficacy therapies are recommended in NMSC due to an increased risk of recurrences and metastases....

  20. Et Patientperspektivistisk Studie i Brug af Alternativ Behandling hos Danske Patienter med Diabetes

    DEFF Research Database (Denmark)

    Gerbild, Helle Nygaard

    2008-01-01

    prevalence in use of CAM, which is generally rather low, especially the CAM used specifically for diabetes. The objective of this paper is to develop concepts to understand patients having experiences and positions of diabetes in their use of CAM. Methods: This qualitative study its inspiration from grounded...... treatment, and this to a relatively low degree. Analyses show that they do not have the strength to follow the conventional recommendations and the alternative self-care management (CAM) at the same time, which may contribute to the understanding of diabetic non-CAM positions. Some of the established...... clients, however, are positioned as user of both complementary and alternative medicine and conventional treatments, such as biological, homeopathic, and traditional Chinese medicine. The main factors that drive them to this are the aim, the hope, the belief, and knowledge how to cure diabetes. Conclusion...

  1. Succesfuld behandling af svær dabigatranoverdosering med idarucizumab hos en patient med nyresvigt

    DEFF Research Database (Denmark)

    Poulsen, Christina Gjerlev; Bestle, Morten; Boesby, Lene

    2017-01-01

    In the course of an uncomplicated sigmoidostomy a 63-year-old male who had severe comorbidity developed a critical bleeding due to dabigatran intoxication induced by acute kidney injury. Massive blood transfusions, tranexamic acid, Octaplex and haemodialysis were not effective. Administration of ...... of idarucizumab induced immediate clinical and paraclinical improvement. Dabigatran should be carefully administrated in patients who have any degree of renal insufficiency. Idarucizumab may be effective in severe bleeding caused by dabigatran.......In the course of an uncomplicated sigmoidostomy a 63-year-old male who had severe comorbidity developed a critical bleeding due to dabigatran intoxication induced by acute kidney injury. Massive blood transfusions, tranexamic acid, Octaplex and haemodialysis were not effective. Administration...

  2. Noninvasiv behandling af slid og erosion

    DEFF Research Database (Denmark)

    Pallesen, Ulla; Dijken, Jan van

    2012-01-01

    Slid og erosion af tænder synes i dag at være et voksende problem for mange patienter. I de fleste tilfælde kan tandlægens tidlige diagnostik føre til, at forebyggende tiltag iværksættes i tide, så fortsatte skader ophører, eller progressionen begrænses. Desværre er det ikke altid muligt, og hvis...... restaureret med fuldkroner på alle tænder. Hvis behandlingen udføres med direkte plast, kan det også betyde, at omkostningerne bliver mindre, så flere får mulighed for at få udført en nødvendig rekonstruktion af tandsættet. I det følgende vil forskellige faktorer i forbindelse med tandslid og erosion blive...

  3. Udvikling af medicinsk behandling mod bipolar lidelse

    DEFF Research Database (Denmark)

    Ellegaard, Pernille Kempel

    2015-01-01

    Selvom Esbjerg ligger i vandkants Danmark, er det den Psykiatriske Forskningsenhed i denne by, der er primus motor for et stort forsøg blandt mennesker, der lider af bipolar lidelse. Forsøget hedder ”NACOS”, og er et medicinsk forsøg til mennesker, der befinder sig i den depressive fase.......Selvom Esbjerg ligger i vandkants Danmark, er det den Psykiatriske Forskningsenhed i denne by, der er primus motor for et stort forsøg blandt mennesker, der lider af bipolar lidelse. Forsøget hedder ”NACOS”, og er et medicinsk forsøg til mennesker, der befinder sig i den depressive fase....

  4. Hvilken evidens er der for medikamentel behandling af depression hos børn og unge?

    DEFF Research Database (Denmark)

    Thomsen, Per Hove; Sørensen, Merete Juul

    2007-01-01

    Depression hos børn og unge er relativt hyppigt forekommende og kan have svære konsekvenser. Den specifikke antidepressive behandling kan være psykoterapeutisk eller medikamentel. I artiklen gennemgås på baggrund af systematisk litteratursøgning den videnskabelige evidens for medikamentel...... behandling af depression hos børn og unge med hovedvægten lagt på de mest veldokumenterede medikamenter: selektive serotoningenoptagelseshæmmere....

  5. Biologisk behandling af sjaeldne inflammatoriske reumatiske sygdomme

    DEFF Research Database (Denmark)

    Baslund, Bo

    2008-01-01

    The current status of the use of biological medicine in the treatment of adult onset morbus still, Wegeners granulomatosis and systemic lupus erythematosus (SLE) is reviewed. The need for controlled trials is emphasized. Anti-CD20 treatment for SLE patients with kidney involvement and patients...... with Wegeners granulomatosis seems promising. Anti-TNF and IL1 receptor antagonist can control disease activity in most patients with adult morbus still....

  6. Interventionel behandling af carotisstenoser--status 2007

    DEFF Research Database (Denmark)

    Schroeder, Torben V; Sillesen, Henrik H

    2007-01-01

    Only symptomatic patients with severe carotid stenosis should be considered for interventional management. Treatment should be initiated within weeks after the first neurological symptom. To save time, diagnostic investigation should be feasible the first time patients are seen. Open surgery...... is evidence-based and first choice. Carotid stenting has not proven superior to carotid endarterectomy. Until further evidence is provided, CAS should be reserved for patients with high surgical risks. All patients, symptomatic as well as asymptomatic, should undergo aggressive risk factor modification....

  7. Lenalidomid til behandling af transfusionskraevende myelodysplastisk syndrom

    DEFF Research Database (Denmark)

    Risum, Malene; Dufva, I.H.

    2010-01-01

    Lenalidomide is the first drug to induce transfusion independence and cytogenetic remission in patients with myelodysplastic syndrome (MDS) with deletion 5q and low or intermediate risk score. Transfusion independence can be obtained within five weeks. Three out of four patients also obtain...

  8. Behandling af Tourettes syndrom med aripiprazol

    DEFF Research Database (Denmark)

    Stenstrøm, Anne Dorte; Sindø, Ingrid

    2008-01-01

    Tourette's syndrome (TS) is a motoric disorder characterised by multiple motor and vocal tics. The treatment for patients with moderate to severe TS includes antipsychotic medication. A case report is described in which a 20 year-old male had taken antipsychotic medication since the age of five......, due to TS. The initial treatment consisted of pimozide and risperidone, both of which had an unsatisfactorily efficacy on tics and side effects in the form of weight gain and sedation. The patient is now treated with aripiprazole and there is a marked reduction of tics and no side effects...

  9. Behandling af diabetes mellitus med biologiske laegemidler

    DEFF Research Database (Denmark)

    Larsen, Claus Morten; Mandrup-Poulsen, Thomas

    2008-01-01

    Biologic therapeutics are currently not approved for the treatment of patients with type 1 and type 2 diabetes. However, promising results from recent randomized controlled studies suggest that biologic therapeutics have therapeutic potential. This article summarizes the causal steps of the patho......Biologic therapeutics are currently not approved for the treatment of patients with type 1 and type 2 diabetes. However, promising results from recent randomized controlled studies suggest that biologic therapeutics have therapeutic potential. This article summarizes the causal steps...... of the pathogenesis of type 1 and type 2 diabetes which are targeted by biologic therapeutics and reviews the treatment results. Udgivelsesdato: 2008-Jun-9...

  10. Operativ behandling af thoracic outlet syndrome

    DEFF Research Database (Denmark)

    Birkeland, Peter; Stiasny, Jerzy

    2012-01-01

    of the brachial plexus. At surgery, we found and severed a fibrous band that compressed the inferior trunk. Postoperatively, the pain subsided and fine hand movements improved. One patient had no cervical rib, however, in the two other cases we found rudimentary cervical ribs. Magnetic resonance imaging...

  11. Biofarmaka til behandling af reumatoid artritis

    DEFF Research Database (Denmark)

    Baslund, Bo; Bendtzen, Klaus

    2008-01-01

    The current status on the use of biopharmaceuticals in the treatment of rheumatoid arthritis is reviewed. Blocking of TNF-alpha, co-stimulation of CD28+ T-cells and depletion of CD20+ B-cells are all effective ways to diminish inflammation and joint damage. However, not all patients react to thes...

  12. Behandling af diabetes mellitus med biologiske laegemidler

    DEFF Research Database (Denmark)

    Larsen, Claus Morten; Mandrup-Poulsen, Thomas

    2008-01-01

    Biologic therapeutics are currently not approved for the treatment of patients with type 1 and type 2 diabetes. However, promising results from recent randomized controlled studies suggest that biologic therapeutics have therapeutic potential. This article summarizes the causal steps...... of the pathogenesis of type 1 and type 2 diabetes which are targeted by biologic therapeutics and reviews the treatment results. Udgivelsesdato: 2008-Jun-9...

  13. Biologisk behandling af psoriasis og psoriasisartritis

    DEFF Research Database (Denmark)

    Kragballe, Knud; Deleuran, Bent

    2008-01-01

    Psoriasis is an immune-mediated inflammatory skin disease which may be associated with psoriatic arthritis. Biological therapy is indicated in patients who do not respond to, or are intolerant to, or have contraindication against traditional therapy. TNFalpha antagonists are used for both skin...

  14. Udredning og behandling af osteoporotiske hoftefrakturer

    DEFF Research Database (Denmark)

    Eiken, Pia A; Abrahamsen, Bo

    2010-01-01

    INTRODUCTION: Osteoporosis is a major cause of low-energy hip fractures. Although there are pharmacologic agents available for both prevention and treatment, less than 10% of hip fracture cases initiate anti-osteoporotic treatment. MATERIAL AND METHODS: In 1995 and 2008, questionnaires were sent ...... departments with orthopaedic surgery functions refer patients to further investigation. There is, however, still room for improvement. Udgivelsesdato: 2010-Mar-1...

  15. Behandling af ideopatisk hypereosinofilt syndrom med imatinib

    DEFF Research Database (Denmark)

    Sørensen, Anne Louise; Larsen, Herdis

    2008-01-01

    We here report a case of idiopathic hypereosinophilic syndrome with prompt response to treatment with imatinib. The patient presented with chest pain, myalgias, fatigue and weakness. Blood tests and bone marrow examination revealed striking eosinophilia. Clonal or reactive disorders were excluded...... by a wide range of diagnostic examinations. Treatment with high-dosis corticosteroids and hydroxyurea had little effect. Additional treatment with imatinib resulted in prompt symptomatic improvement and full haematological remission within five days of therapy. Udgivelsesdato: 2008-Jan-21...

  16. Medicinsk vs. kirurgisk behandling af svært overvægtige patienter med type 2-diabetes

    DEFF Research Database (Denmark)

    Svane, Maria Saur; Bojsen-Møller, Kirstine Nyvold; Madsbad, Sten

    2016-01-01

    Bariatric surgery induces large and sustainable weight loss in obese patients and improves glycaemic control in patients with Type 2 diabetes. Eleven randomized controlled trials have shown superior glycaemic outcomes after bariatric procedures vs. medical therapy/intensive lifestyle interventions...... in obese patients with Type 2 diabetes. Furthermore, many patients experience remission of Type 2 diabetes after surgery but relapse may occur during follow-up. Data from observational studies show reduced incidence of micro- and macrovascular complications in addition to reduced cardiovascular and total...... mortality after surgery....

  17. Behandling af epilepsi ved stimulation af nervus vagus

    DEFF Research Database (Denmark)

    Hansen, Christian Pilebaek; Sidenius, Per Christian; Gyllenborg, Jesper

    2010-01-01

    Epilepsy is a common neurological disorder, and between one fourth and one third of the patients do not obtain seizure freedom after treatment with antiepileptic drugs. If the epileptic seizures in such patients have severe consequences, the patients should be assessed for epilepsy surgery. In ca...

  18. Forebyggelse af infektioner hos patienter, der har kronisk inflammatorisk tarmsygdom og er i behandling med TNF-hæmmere

    DEFF Research Database (Denmark)

    Risager Christensen, Katrine; Steenholdt, Casper

    2014-01-01

    suppression of the immune system. National and international guidelines recommend screening and vaccination for selected infectious agents prior to anti-TNF initiation as well as during ongoing anti-TNF therapy. This review focuses on current available recommendations and discusses physicians’ and patients......Prevention of infections in patients with inflammatory bowel disease during TNF inhibitor treatment Treatment of inflammatory bowel disease with anti-tumour necrosis factor (TNF)-alpha biopharmaceuticals is generally well tolerated, but increases the risk of infections due to globally induced...

  19. Behandling af epilepsi ved stimulation af nervus vagus

    DEFF Research Database (Denmark)

    Hansen, Christian Pilebaek; Sidenius, Per Christian; Gyllenborg, Jesper

    2010-01-01

    epilepsy surgery is not feasible, vagus nerve stimulation (VNS) should be offered. VNS seems to have an effect in all epilepsy syndromes and seizure types. VNS is generally well-tolerated, and may even improve mood and quality of life. Many more epilepsy patients in Denmark should be offered VNS....

  20. Forebyggelse og behandling af osteoporose i forbindelse med behandling af ikke-metastaserende prostatacancer

    DEFF Research Database (Denmark)

    Eiken, Pia Agnete; Langdahl, Bente Lomholt; Eiken, Frederik L

    2011-01-01

    The prevention of cancer treatment-induced bone loss in patients with prostatae cancer due to gonadotropin-releasing hormone (GnRH)-agonist, GnRH-antagonist and orchidectomi therapy has a high priority. We present an algorithm for the prevention and treatment of osteoporosis during treatment of non......-metastatic prostate cancer....

  1. Non-invasiv behandling af slid og erosion

    DEFF Research Database (Denmark)

    Pallesen, Ulla; van Dijken, Jan WV

    2011-01-01

    Slid og erosion af tænder synes i dag at være et voksende problem for mange patienter. I de fleste tilfælde kan tandlægens tidlige diagnostik føre til, at forebyggende tiltag iværksættes i tide, så fortsatte skader ophører eller progressionen begrænses. Desværre er det ikke altid muligt og hvis s...

  2. Non-invasiv behandling af slid og erosion

    DEFF Research Database (Denmark)

    Pallesen, Ulla; van Dijken, Jan WV

    2011-01-01

    Slid og erosion af tænder synes i dag at være et voksende problem for mange patienter. I de fleste tilfælde kan tandlægens tidlige diagnostik føre til, at forebyggende tiltag iværksættes i tide, så fortsatte skader ophører eller progressionen begrænses. Desværre er det ikke altid muligt og hvis...... restaureret med fuldkroner på alle tænder. Hvis behandlingen udføres med direkte plast, kan det også betyde, at omkostningerne bliver mindre, så flere får mulighed for at få udført en nødvendig rekonstruktion af tandsættet. I det følgende vil forskellige faktorer i forbindelse med tandslid og erosion blive...

  3. Alternativ behandling og kræft

    DEFF Research Database (Denmark)

    Lunde, Anita; Johannessen, Helle

    2010-01-01

    Baggrund: Interessen for komplementær og alternativ behandling (KAB) er stadig stigende, og der kan dokumenteres et større forbrug af KAB blandt kræftpatienter. Patienter anvender primært KAB som supplement til deres konventionelle behandling, og mange så gerne KAB som en integreret praksis. Fler...

  4. Momsmæssig behandling af porteføljeforvaltning

    DEFF Research Database (Denmark)

    Thygesen, Jette

    2015-01-01

    I 2012 kom EU-domstolens afgørelse i Deutsche Bank sagen. Med Deutsche Bank afgørelsen kom der en ny udvikling i fortolkningen af sammensatte ydelsers momsmæssige status. Således afgjorde EU-domstolen, at når en sammensat ydelse ikke kan opdeles, uden dette virker kunstigt, da ydelsen bestå af...

  5. Længerevarende behandling af børn og unge i sikrede pladser

    DEFF Research Database (Denmark)

    Bonke, Jens; Kofoed Rasmussen, Lene

    I slutningen af 1990'erne blev der åbnet for, at landets sikrede institutioner kunne anvendes til længerevarende behandlingsforløb for unge kriminelle eller kriminalitetstruede. Ordningen har kun været benyttet i ringe grad og har været praktiseret meget forskelligt i de involverede institutioner....... Denne evaluering bidrager således først og fremmest til at rejse en række spørgsmål, der kan være med til at kvalificere perspektiverne i at anbringe og behandle unge i sikret regi. Nogle institutioner har iværksat en egentlig behandlingsindsats, mens andre i højere grad har set det som deres opgave...... hurtigst muligt at få de unge anbragt i ikke-sikret regi. De unge er desuden meget forskellige, hvilket gør det vanskeligt at vurdere virkningen af længerevarende behandling i sikret regi. Evalueringen af ordningen bygger på interview med de respektive amter, med de implicerede institutioner, med unge der...

  6. Hvilken evidens er der for behandling af depression hos børn og unge med kognitiv terapi?

    DEFF Research Database (Denmark)

    Sørensen, Merete Juul; Thomsen, Per Hove

    2007-01-01

    Depression hos børn og unge er relativt hyppigt forekommende og kan have svære konsekvenser. Den specifikke antidepressive behandling kan være psykoterapeutisk eller medikamentel. I artiklen gennemgås på baggrund af systematisk litteratursøgning den videnskabelige evidens for effekten af kognitiv...... adfærdsterapi hos børn og unge med depression....

  7. Receptindløst anti-osteoporotisk behandling i Danmark

    DEFF Research Database (Denmark)

    Hansen, Carrinna; Konradsen, Hanne; Pedersen, Birthe D.

    den farmaceutiske behandling er fortsat uklare. Formål: At opnå en dybere forståelse af patienters liv med osteoporose ved at bestemme omfanget af, samt beskrive faktorer vedrørende receptindløst compliance og vedholdenhed af oral anti-osteoporotisk behandling blandt nye brugere af oral anti......-osteoporotisk medicin i Danmark. Metode: En epidemiologisk registerbaseret national åben kohorte undersøgelse af compliance og vedholdenhed af anti-osteoporotisk behandling. Undersøgelsen omfattede 100.949 mænd og kvinder. Statistiske analyser blev anvendt til at forklare årsager til behandlingssvigt, herunder backward...... præparater, hormon behandling, prednisolon og anti-depressiva, ko-morbiditeter særligt 3 og derover, lunge og reumatologisk lidelser. Konklusion: Studiets fund bidrager med ny viden vedrørende compliance problematikken, ved at beskrive afgørende faktorer for potentielle risikogrupper. Resultaterne peger...

  8. Behandling af peritoneal karcinose med laparoskopisk intraperitoneal kemoterapi under tryk

    DEFF Research Database (Denmark)

    Graversen, Martin; Pfeiffer, Per; Mortensen, Michael Bau

    2016-01-01

    Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a new treatment option in patients with peritoneal carcinomatosis (PC). PIPAC has proven efficacious in the treatment of PC from ovarian, colon and gastric cancer. PIPAC has a favourable profile regarding safety for patients and occupati......Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a new treatment option in patients with peritoneal carcinomatosis (PC). PIPAC has proven efficacious in the treatment of PC from ovarian, colon and gastric cancer. PIPAC has a favourable profile regarding safety for patients...

  9. Behandling af suicidalpatienter: Collaborative Assessment and Management of Suicidality

    DEFF Research Database (Denmark)

    Arkov, Kirsten; Rosenbaum, Bent; Christiansen, Lene

    2008-01-01

    There is still a need for more knowledge about effective methods of assessing and treating the suicidal patient. The method The Collaborative Assessment and Management of Suicidality (CAMS) was tested on a group of out-patients.......There is still a need for more knowledge about effective methods of assessing and treating the suicidal patient. The method The Collaborative Assessment and Management of Suicidality (CAMS) was tested on a group of out-patients....

  10. Muskuloskeletal behandling af 11-årig med artrogrypose

    DEFF Research Database (Denmark)

    Thomsen, Maria Morandi; Thomsen, Stig Aaberg; Due, Pernille

    2010-01-01

    A two-year-old patient was diagnosed with arthrogryposis because of inflected knees (15-20 degrees) and stiff hamstrings. All joints and reflexes were normal. Activities were described as age-appropriate, but the patient walked with inflected knees and increased lumbal lordosis. Physiotherapy and...... and botox did not improve the condition. Because of pain and hampered activities, the patient - now aged 11 years - was treated with musculoskeletal medicine. After treatment the patient could walk normally without pain and stand with stretched knees.......A two-year-old patient was diagnosed with arthrogryposis because of inflected knees (15-20 degrees) and stiff hamstrings. All joints and reflexes were normal. Activities were described as age-appropriate, but the patient walked with inflected knees and increased lumbal lordosis. Physiotherapy...

  11. Trombosering af mekanisk mitralklapprotese under behandling med dabigatran

    DEFF Research Database (Denmark)

    Thomsen, Jakob Hartvig; Kjaergaard, Jesper; Saust, Laura Trolle

    2014-01-01

    Dabigatran has been approved for prevention of thromboembolic complications in nonvalvular atrial fibrillation. We present a case of thrombosis of a mechanical prosthetic mitral valve during anticoagulation with dabigatran, switched from warfarin. The patient presented with cardiogenic shock......, was treated with thrombolytic therapy and discharged with warfarin therapy. Dabigatran in patients with mechanical valve prosthesis should be avoided and echocardiography is indicated if dyspnoea develops in such patients....

  12. Farmakologisk behandling af mild ukompliceret hypertension i almen praksis

    DEFF Research Database (Denmark)

    Paulsen, Maja Skov; Christensen, Bo; Søndergaard, Jens

    2013-01-01

    Hypertension is an important risk factor for cardiovascular disease. In Denmark, patients with hypertension are primarily managed in primary care. A recent Cochrane review concluded that pharmacotherapy of patients with mild hypertension (systolic blood pressure 140-159 mmHg; diastolic blood...... pressure 90-99 mmHg; no diabetes or cardiovascular disease) did not reduce mortality or morbidity. The evidence for pharmacotherapy in patients having mild/uncomplicated hypertension is weak. However, current Danish guidelines have taken this into consideration in their recommendations of pharmacotherapy...... to patients with mild/uncomplicated hypertension....

  13. Gener efter behandling af almindeligt forekommende akutte øjenlidelser

    DEFF Research Database (Denmark)

    Krogsgaard, M R; Danborg, L; Jensen, P

    1990-01-01

    was present. Patients with photoelectric conjunctivitis and conjunctivitis caused by chemical products had the shortest durations of symptoms. Patients with pain should be treated with analgesic tablets as the pain-relief after application of local anaesthetics was brief. Only half of those who had...

  14. Salmonella typhi--tid til aendring af den empiriske behandling

    DEFF Research Database (Denmark)

    Gade, Christina; Engberg, Jørgen; Weis, Nina

    2008-01-01

    In the present case series report we describe seven recent cases of typhoid fever. All the patients were travellers returning from Pakistan, where typhoid is endemic. Salmonella typhi isolated from the patients by blood culture were reported as intermediary susceptible to fluoroquinolones in six...

  15. Ventrikulaere takyarytmier. En retrospektiv analyse af aetiologi, demografi og behandling

    DEFF Research Database (Denmark)

    Christensen, Alex Hørby; Henningsen, Kristoffer; Svendsen, Jesper Hastrup

    2008-01-01

    INTRODUCTION: The aim of this study was to investigate the age, sex, etiology, frequency of implantable cardioverter-defibrillator (ICD) and previous cardiac arrest among patients discharged from the Department of Cardiology, Rigshospitalet (Copenhagen University Hospital), Denmark, due to ventri......INTRODUCTION: The aim of this study was to investigate the age, sex, etiology, frequency of implantable cardioverter-defibrillator (ICD) and previous cardiac arrest among patients discharged from the Department of Cardiology, Rigshospitalet (Copenhagen University Hospital), Denmark, due...... unknown etiology; 492 (50%) of the patients overall had an ICD implanted, the majority of whom had been categorized as having ventricular tachycardia (92%); 168 patients had previous cardiac arrest, 127 of whom did not have a potential reversible cause. Of this group 75 (59%) had an ICD implanted...

  16. Omkostningseffektivitet ved behandling af type 1-diabetes med insulinpumpe

    DEFF Research Database (Denmark)

    Nørgaard, Kirsten; Sohlberg, Anna; Goodall, Gordan

    2010-01-01

    This study's aim was to project the long-term clinical and economic outcomes of continuous subcutaneous insulin infusion (CSII) treatment compared to multiple daily injections (MDI) in type 1 diabetes patients in Denmark.......This study's aim was to project the long-term clinical and economic outcomes of continuous subcutaneous insulin infusion (CSII) treatment compared to multiple daily injections (MDI) in type 1 diabetes patients in Denmark....

  17. Linezolid som behandling af infektiøs endokarditis

    DEFF Research Database (Denmark)

    Lauridsen, Trine Kiilerich; Arpi, Magnus; Bruun, Niels Eske

    2010-01-01

    In Denmark enterococci causes 15 to 20% of all endocarditis (IE) cases. The development of multi-resistant bacterial strains has increased the need for new antibiotics. Linezolid is an alternative to conventional treatment of infections with gram positive cocci. In this case report linezolid...... was used to treat IE in a patient, who was allergic to penicillin and where conventional treatment caused development of acute renal failure. No side effects were observed and the patient responded well to the treatment....

  18. Behandling af metforminassocieret laktatacidose med hæmodialyse

    DEFF Research Database (Denmark)

    Schousboe, Karin; El Fassi, Daniel; Secher, Erik Lilja

    2012-01-01

    Metformin-associated lactate acidosis is rare but serious and characterized by metabolic acidosis and elevated lactate. We describe a single-institution experience of four cases in one year. Despite pH levels of 6.85 to 7.12 and lactate levels of 11-28 mmol/l three of the patients survived. Two o...... of the patients had normal kidney function previous to hospitalization. Treatment includes fluid replacement, IV sodium bicarbonate and haemodialysis....

  19. Behandling af juvenile angiofibromer med partikelembolisering og endoskopisk kirurgi

    DEFF Research Database (Denmark)

    Thuesen, Anne Daugaard; Jakobsen, John; Nepper-Rasmussen, Jørgen

    2005-01-01

    AND METHODS: A retrospective review of the eight patients who have been treated since 1997 was done. The embolization, which was carried out in the radiotherapy department, was done with polyvinyl alcohol particles in the vessels that supply the tumor. The operation was then performed in the ear, nose...... and throat department of OUH. The tumor was removed endoscopically in all cases in which it was possible. RESULTS: All eight patients were embolized preoperatively. The average preoperative bleeding was 375 ml, a little less when endoscopic access was possible. This is in agreement with the literature...

  20. Salmonella typhi--tid til aendring af den empiriske behandling

    DEFF Research Database (Denmark)

    Gade, Christina; Engberg, Jørgen; Weis, Nina

    2008-01-01

    In the present case series report we describe seven recent cases of typhoid fever. All the patients were travellers returning from Pakistan, where typhoid is endemic. Salmonella typhi isolated from the patients by blood culture were reported as intermediary susceptible to fluoroquinolones in six...... out of seven cases. We recommend that empiric treatment of suspected cases of typhoid fever includes a third generation cephalosporin such as ceftriaxon. Furthermore, the present report stresses the importance of typhoid vaccination of travellers to areas where typhoid is endemic. Udgivelsesdato: 2008...

  1. Ikkekirurgisk behandling af lumbal nerverodspåvirkning

    DEFF Research Database (Denmark)

    Andersen, Mikkel Østerheden; Andresen, Andreas K; Lorenzen, Marianne Dyrby

    2017-01-01

    evidence is found regarding non-surgical treatment of patients with lumbar radiculopathy. Physiotherapy, in the form of group sessions, seems to have the best level of evidence. However, evidence is still very limited and of poor quality. No evidence has been found with regards to acupuncture...

  2. Behandling af metforminassocieret laktatacidose med hæmodialyse

    DEFF Research Database (Denmark)

    Schousboe, Karin; El Fassi, Daniel; Secher, Erik Lilja

    2012-01-01

    Metformin-associated lactate acidosis is rare but serious and characterized by metabolic acidosis and elevated lactate. We describe a single-institution experience of four cases in one year. Despite pH levels of 6.85 to 7.12 and lactate levels of 11-28 mmol/l three of the patients survived. Two...

  3. Utilfredsstillende langtidsresultater efter konservativ behandling af patellofemoralt smertesyndrom

    DEFF Research Database (Denmark)

    Rathleff, Michael Skovdal; Rasmussen, Sten; Olesen, Jens Lykkegaard

    2012-01-01

    This review overviews the long-term prognosis of conservatively treated patients with patellofemoral pain syndrome (PFPS). Median values of the 16 included studies show that 29% of soldiers, 27.8% of sports active and 24,7% of the general public will become pain free after they are diagnosed...

  4. Nyrepåvirkning ved behandling af hjertesvigt

    DEFF Research Database (Denmark)

    Rasmussen, Zhiying Zhang; Barfod, Toke; Klit, Jakob

    2009-01-01

    The case of a 66-year-old male with heart failure and cardiorenal syndrome is presented. The patient had normal renal function before intensive treatment with diuretics and ACE inhibitor. Shortly after the ACE inhibitor was stopped and diuretics were either stopped or reduced in dosage, his renal...

  5. Behandling af centralnervesystemlymfom efter transplantation med monoklonalt antistof og ganciclovir

    DEFF Research Database (Denmark)

    Hansen, P.B.; Al-Farra, G.

    2010-01-01

    A 35-year-old female was diagnosed with a primary central nervous system posttransplant Epstein-Barr-virus-associated lymphoproliferative disorder three years after a renal transplantation. The histological diagnosis of the brain tumour was a diffuse large B-cell lymphoma. The patient had had...

  6. Den initiale behandling af svært tilskadekomne traumepatienter

    DEFF Research Database (Denmark)

    Steinmetz, Jacob; Svendsen, Lars Bo

    2014-01-01

    Multitrauma is usually defined as injury to several organ systems. The more severe the injury, the higher is the mortality. It is essential that a trauma team assess and treat these patients using a rapid, structured approach in order to increase the survival. Damage control surgery and resuscita...

  7. Rituximab (MabThera) til behandling af aktiv reumatoid artritis

    DEFF Research Database (Denmark)

    El Fassi, Daniel; Nielsen, Claus Henrik; Bendtzen, Klaus

    2006-01-01

    Rituximab (RTX) is a murine/human monoclonal antibody to CD20, a protein expressed almost exclusively on human B-lymphocytes. RTX induces rapid and marked B-cell depletion with beneficial clinical effects in 1/3 to 1/2 of rheumatoid arthritis patients. Treatment is given as two iv. infusions with...

  8. Diagnostik og behandling af paroksystisk supraventrikulær takykardi

    DEFF Research Database (Denmark)

    Rujic, Dragana; Sundbøll, Jens; Tofig, Bawer Jalal

    2016-01-01

    The paroxysmal supraventricular tachycardias (SVT) are commonly encountered arrhythmias and include atrioventricular nodal re-entrant tachycardia, atrioventricular reciprocating tachycardia, and focal atrial tachycardia. These tachycardias share several clinical features as well as similar...... management strategies. The probable mechanism of paroxysmal SVT can often be diagnosed from the clinical findings and a 12-lead ECG. This review describes the initial evaluation and treatment of patients with paroxysmal SVT, including distinctive features from the most important differential diagnoses....

  9. Intranasal glukagon til behandling af hypoglykaemi. En fremtidig behandlingsmulighed

    DEFF Research Database (Denmark)

    Carstens, S; Andersen, I; Gustafsson, Ida

    1994-01-01

    Nearly 10% of IDDM patients receiving conventional insulin treatment and about three times as many in intensive insulin therapy yearly experience severe hypoglycaemia (requiring external assistance) The conventional treatment of severe hypoglycaemia is glucagon given intramuscularly by a relative...... or glucose administered intravenously by a physician. These are however not optimal treatments. Obtaining intravenous access requires a medical doctor and glucagon injection is not always properly done by family members. Glucagon administered intranasally has been proven to raise blood glucose levels...

  10. Fækal mikrobiota-transplantation til behandling af tarmlidelser

    DEFF Research Database (Denmark)

    Rode, Anne A; Chehri, Mahtab; Petersen, Andreas Munk

    2017-01-01

    Faecal microbiota transplantation (FMT) is the transferral of faeces from a healthy donor to a patient with a disease linked to disturbances in the gut microbiota. The treatment has been implemented at several hospitals in Denmark, and banks with frozen donor stool material have been established........ The effect of FMT for recurrent Clostridium difficile infection is well-documented. FMT cannot be recommended for routine clinical use for inflammatory bowel disease and irritable bowel syndrome because of lack of data from clinical trials....

  11. Ticsundertrykkelse er en ny evidensbaseret nonfarmakologisk behandling af ticslidelse

    DEFF Research Database (Denmark)

    Sørensen, Camilla Birgitte; Debes, Nanette Mol; Skov, Liselotte

    2017-01-01

    Chronic tic disorder and Tourette syndrome are both chronic and impairing neurobiological disorders starting in childhood with a prevalence between 0.4 and 1.6%. Traditionally, pharmacological therapies have been first-line treatment but are often associated with adverse effects. Recently...... behavioural therapy has shown to be effective in treating tics and today both habit reversal (HR) and exposure and response prevention (ERP) are recommended as first-line treatments. HR and ERP are now available for Danish patients. This article describes the evidence and recommendations for both therapies....

  12. Filetlap til behandling af livstruende tryksår

    DEFF Research Database (Denmark)

    Gunnarsson, Gudjon Leifur; Høimyr, Hilde; Rossi, Paolo Emilio

    2014-01-01

    reconstruction of the defect was performed. The patient made uneventful recovery to normal activity within six weeks and had a stable result after one year follow-up. The case is a reminder of the importance of early intervention and preventive management of pressure ulcers and elaborates the benefits......A 71-year-old multi-morbid, paraplegic male with five pressure ulcers and a left-sided open trochanter fracture with chronic osteomyelitis was admitted to hospital. His condition required exarticulation of the left hip joint. A radical wound revision and a pedicled lower extremity fillet flap...... of interdisciplinary team efforts in the treatment of advanced ulcers....

  13. Behandling af centralnervesystemlymfom efter transplantation med monoklonalt antistof og ganciclovir

    DEFF Research Database (Denmark)

    Hansen, P.B.; Al-Farra, G.

    2010-01-01

    A 35-year-old female was diagnosed with a primary central nervous system posttransplant Epstein-Barr-virus-associated lymphoproliferative disorder three years after a renal transplantation. The histological diagnosis of the brain tumour was a diffuse large B-cell lymphoma. The patient had had...... diabetes mellitus for 28 years and was treated with four weekly doses of the monoclonal antibody rituximab, the antiviral drug ganciclovir and high-dose prednisolone, and the immune suppression was reduced. After four weeks of treatment, a control magnetic resonance image showed complete regression...

  14. Endoventrikulaer venstre ventrikel-rekonstruktion til behandling af hjerteinsufficiens

    DEFF Research Database (Denmark)

    Funder, Jonas Amstrup; Klaaborg, Kaj-Erik; Egeblad, Henrik

    2009-01-01

    INTRODUCTION: Surgical ventricular reconstruction is an option for treatment of heart failure elicited by left ventricular aneurism. The aim of this study was to report the results of such treatment in our tertiary centre. MATERIAL AND METHODS: From January 2002 through October 2007 surgical...... data retrospectively. RESULTS: Eighty-five percent of the patients received additional operative procedures, in most cases coronary artery bypass grafting. Ninety-six percent survived the follow-up period which had a median duration of 392 days (1-1777). At follow-up left ventricular ejection fraction...

  15. Forekomst og behandling af seksuel dysfunktion ved hjertesygdom

    DEFF Research Database (Denmark)

    Mickley, Hans

    2002-01-01

    Several links have been established between sexual dysfunction and heart disease. Indeed, many risk factors for developing sexual dysfunction are shared by coronary artery disease: age, smoking, diabetes, hypertension, and hypercholesterolaemia. It should also be borne in mind that in men several...... cardiac drugs are responsible for erectile dysfunction (ED). Lastly it should be remembered that treatment of ED may be associated with cardiovascular side-effects. Data from the literature show that men with coronary artery disease, hypertension or diabetes have an up to fourfold higher risk...... of developing ED than have age-matched controls. Thiazide diuretics and beta-blockers are the most common drugs that produce ED. Current therapies for ED are safe and effective in the large majority of patients with cardiovascular disease. However, the concomitant use of nitrates and sildenafil may be life...

  16. Tiotropium. Nyt antikolinergikum til behandling af kronisk obstruktiv lungesygdom

    DEFF Research Database (Denmark)

    Pedersen, Steffen Thirstrup; Lange, Peter

    2003-01-01

    Tiotropium is a new anti-cholinergic drug with a long duration of action designed for maintenance treatment of chronic obstructive pulmonary disease (COPD). Tiotropium is the first drug specifically developed for the treatment of COPD, but it is also amongst the most expensive drugs used for this......Tiotropium is a new anti-cholinergic drug with a long duration of action designed for maintenance treatment of chronic obstructive pulmonary disease (COPD). Tiotropium is the first drug specifically developed for the treatment of COPD, but it is also amongst the most expensive drugs used...... for this condition. The clinical pharmacology of tiotropium and results from published controlled clinical trials are reviewed. It is concluded that tiotropium seems suitable as a symptomatic treatment for patients with moderate to severe COPD (typically a forced expiratorical volume FEV1 predicted...

  17. Præhospital behandling af svært tilskadekomne patienter med fokus på damage control-kirurgi

    DEFF Research Database (Denmark)

    Sørensen, Anne Marie; Larsen, Claus Falck; Steinmetz, Jacob

    2011-01-01

    The majority of patients undergoing damage control surgery initially receive prehospital treatment. Bleeding causes 40% of trauma deaths, half of which happen in the prehospital setting. Future research and improved treatment before hospital admission should focus on control of the bleeding, avoi...

  18. Præhospital behandling af svært tilskadekomne patienter med fokus på damage control-kirurgi

    DEFF Research Database (Denmark)

    Sørensen, Anne Marie; Larsen, Claus Falck; Steinmetz, Jacob

    2011-01-01

    The majority of patients undergoing damage control surgery initially receive prehospital treatment. Bleeding causes 40% of trauma deaths, half of which happen in the prehospital setting. Future research and improved treatment before hospital admission should focus on control of the bleeding...

  19. Betydningen af kroppens stilling for det diuretiske respons ved behandling af dekompenseret cirrose og morbus cordis

    DEFF Research Database (Denmark)

    Wilken-Jensen, C; Ring-Larsen, H; Henriksen, Jens Henrik Sahl

    1989-01-01

    The diuretic effect of the supine position was evaluated in six patients with cirrhosis and ascites and six with congestive cardiac failure. All patients received 1 mg bumethanide intravenously and were randomly assigned to either bed rest in the supine position or normal daily activity in the up...

  20. Kvaliteten af diagnostik og behandling af kronisk obstruktiv lungesygdom i almen praksis--sekundaerpublikation

    DEFF Research Database (Denmark)

    Lange, Peter; Rasmussen, Finn Vejlø; Borgeskov, Hanne

    2008-01-01

    included in the first audit and 2394 in the second audit. We observed a significantly increased utilisation of spirometry from the first (52.7%) to the second audit (71.4%) (p quality of management. We conclude that participation in an educational......We investigated whether the quality of management of COPD in general practice could be improved by the participation of general practitioners and their staff in a COPD-specific educational programme. One-hundred and fifty-four doctors participated in the study, and 2549 patient record forms were...... programme can improve the quality of COPD care in general practice....

  1. Prognostiske faktorer af betydning for den recidivfrie overlevelse efter kirurgisk behandling af hoved-hals-melanom

    DEFF Research Database (Denmark)

    Andersson, A P; Gottlieb, J; Søndergaard, K

    1993-01-01

    , range 1 month to 25 years. Sex, age, ulcerated tumor and tumor thickness were found by Cox multivariate regression analysis to act as independent prognostic factors for recurrence-free survival. In addition, size of the excision margin was found of no significance for survival without relapse when......The clinico-pathological and therapeutic data of 512 patients with clinical stage I invasive head and neck melanoma of the skin were re-evaluated. There were 287 females and 225 males. The median age at primary surgery was 65 years, range 18 to 96 years. The median observation period was 5 years...

  2. Prognostiske faktorer af betydning for den recidivfrie overlevelse efter kirurgisk behandling af hoved-hals-melanom

    DEFF Research Database (Denmark)

    Andersson, A P; Gottlieb, J; Søndergaard, K

    1993-01-01

    The clinico-pathological and therapeutic data of 512 patients with clinical stage I invasive head and neck melanoma of the skin were re-evaluated. There were 287 females and 225 males. The median age at primary surgery was 65 years, range 18 to 96 years. The median observation period was 5 years......, range 1 month to 25 years. Sex, age, ulcerated tumor and tumor thickness were found by Cox multivariate regression analysis to act as independent prognostic factors for recurrence-free survival. In addition, size of the excision margin was found of no significance for survival without relapse when...

  3. Akut induceret diabetes mellitus hos en patient i behandling for metastaserende malignt melanom

    DEFF Research Database (Denmark)

    Bisgaard Jørgensen, Line; Yderstræde, Knud Bonnet

    2018-01-01

    Behandling med immuncheckpointhæmmere ved dissemineret malignt melanom har vundet betydeligt indpas i de seneste par år pga. effekten på overlevelsen hos patienterne med denne lidelse. Der er beskrevet en række endokrinologisk relaterede bivirkninger af behandlingen, herunder hypofysitis og...... tyroiditis/myksødem. På kasuistisk niveau er der desuden beskrevet få tilfælde af akut opstået diabetes mellitus...

  4. Effekt af kompenserende strategier rettet mod kognitive deficits ved skizofreni

    DEFF Research Database (Denmark)

    Hansen, Jens Peter; Hounsgaard, Lise; Jensen, Birte Østergaard

    konkluderes, hvorvidt CAT kan tilbydes som supplement til nuværende tilbud. Formålet med undersøgelsen: At evaluere effekten af CAT behandling sammenlignet konventionel behandling med fokus på sociale funktioner, symptomer, tilbagefald, genindlæggelser og livskvalitet, hos ambulante patienter med skizofreni...

  5. Dermatologiske reaktioner hos patienter i antineoplastisk behandling

    DEFF Research Database (Denmark)

    Prasad, Sumangali Chandra; Vestergaard, Hanne; Bygum, Anette

    2014-01-01

    Every year more than 33,000 Danish patients are treated with traditional chemotherapy or targeted therapy against cancer. Cutaneous side effects to these therapies are common and may contribute significantly to the morbidity, but rarely to the mortality of the patients undergoing these treatments....... We present the most classical types of drug rashes associated with antineoplastic therapy. Haematologists, oncologists and dermatologists should be aware of these reactions and early recognition and management is important for providing optimal care....

  6. The effects of real-time telemedicine video consultations between nurses and patients with severe Chronic Obstructive Pulmonary Disease (COPD)

    DEFF Research Database (Denmark)

    Sorknæs, Anne Dichmann

    Formålet med ph.d. studiet var at undersøge effekten af telekonsultationer som supplement til konventionel behandling sammenlignet med konventionel behandling hos udskrevne patienter med KOL med fokus på genindlæggelser, dødelighed, sundhedsøkonomi, sygeplejerskers og patienters oplevelse af tele...

  7. Forskelle på ordinationsmønstret af analgetika ved behandling af cancersmerter på seks danske smertebehandlingsenheder

    DEFF Research Database (Denmark)

    Olesen, Anne Estrup; Jarvig, Line; Hansen, Ole Bo

    2007-01-01

    30-40% of cancer patients suffer from pain at diagnosis while 70-80% of patients at progressed stages of the disease suffer from pain. Background pain is treated with long-acting opioids. Breakthrough pain can be treated with shorter acting non-opioid analgesics or opioids. The aim of this study ...

  8. ACE-inhibitorer er fortsat førstevalg ved behandling af hjertesvigt--en gennemgang af et Cochranereview

    DEFF Research Database (Denmark)

    Gadsbøll, Niels; Torp-Pedersen, Christian Tobias

    2013-01-01

    A new Cochrane metaanalysis has reviewed the literature on the use of angiotensin receptor blockers (ARB) in patients with heart failure and left ventricular systolic dysfunction. The conclusion supports the present recommendation from the European Society of Cardiology that angiotensin converting...... enzyme inhibitors (ACE-I) are first choice and that ARBs should be reserved to patients who are intolerant to ACE-Is. Neither ACE-Is nor ARBs are effective in the treatment of heart failure patients with normal left ventricular function....

  9. Fedmekirurgi er mere effektiv end medicinsk behandling til opnåelse af remission af type 2-diabetes

    DEFF Research Database (Denmark)

    Klein, Mads; Rosenberg, Jacob; Gögenur, Ismail

    2013-01-01

    Observational studies have shown that bariatric surgery can lead to remission of diabetes mellitus type 2 (DMII), but randomized controlled trials have been lacking. Recently, randomized controlled trials comparing bariatric surgery with optimal medical treatment in patients suffering from poorly...... controlled DMII, have been performed. These trials show that bariatric surgery in general, and the malabsorptive procedures in particular, are more effective than medical treatment in achieving remission of DMII. These procedures should therefore be considered in the treatment of patients with DMII...

  10. Behandling af reumatoid artrit med anti-tumornekrosefaktor-alpha-antistof. Individuel monitorering af biotilgaengelighed og immunogenicitet-- sekundaerpublikation

    DEFF Research Database (Denmark)

    Bendtzen, Klaus; Geborek, Pierre; Svenson, Morten

    2007-01-01

    Remicade/infliximab is effective in rheumatoid arthritis (RA), but response failure is frequent. Sera from 106 RA patients were monitored using an RIA for functional infliximab and an RIA for anti-infliximab antibody (Ab). S-infliximab varied considerably, e.g. 0-22 microg/ml before the 3rd infus...

  11. Forskelle på ordinationsmønstret af analgetika ved behandling af cancersmerter på seks danske smertebehandlingsenheder

    DEFF Research Database (Denmark)

    Olesen, Anne Estrup; Jarvig, Line; Hansen, Ole Bo

    2007-01-01

    was to describe the medical treatment of pain in cancer patients in connection with six Danish hospital units with special expertise in pain treatment. Differences in the prescription of analgesics were studied. The study was performed as a cross section study of prescribed analgesics. Data was collected...... of breakthrough pain. Differences in the prescription of analgesics between the six hospital units were observed in this study....

  12. Behandling af reumatoid artrit med anti-tumornekrosefaktor-alpha-antistof. Individuel monitorering af biotilgaengelighed og immunogenicitet-- sekundaerpublikation

    DEFF Research Database (Denmark)

    Bendtzen, Klaus; Geborek, Pierre; Svenson, Morten

    2007-01-01

    infusion, and 44% were Ab-positive after 6 months. Low s-infliximab was associated with Ab development and later therapeutic failure, and high Ab levels could be related to dose increases, side-effects and cessation of therapy. Pharmacological monitoring should help optimize anti-TNF therapies.......Remicade/infliximab is effective in rheumatoid arthritis (RA), but response failure is frequent. Sera from 106 RA patients were monitored using an RIA for functional infliximab and an RIA for anti-infliximab antibody (Ab). S-infliximab varied considerably, e.g. 0-22 microg/ml before the 3rd...

  13. Behandling af blødende øsofagusvaricer med selvekspanderende metalstenter

    DEFF Research Database (Denmark)

    Dahlerup, Jens F; Kruse, Aksel; Grønbaek, Henning

    2007-01-01

    We report that haemostasis was obtained by the use of SEMS in two patients with bleeding oesophageal varices which failed conventional therapy (vasoactive drugs, antibiotics, endoscopy, and Sengstaken balloon tamponade). One patient subsequently died of sepsis; the other was treated with TIPS...

  14. Omkostningseffektiv ændring af behandling ved delhudstransplantat på crus

    DEFF Research Database (Denmark)

    Vennegaard Kalialis, Louise; von Sperling, Marie Louise; Hoyer, A.P.

    2012-01-01

    We present a clinical comparison of short stretch bandage versus a two-layer compression bandage and early mobilization after split skin grafting to lower leg defects. A total of 38 patients were included. The first group were immobilized for four days and given a short stretch support bandage....... Group 2 were mobilized one day after the operation with a two-layer compression bandage (Pro-Guide). There was no difference in healing or frequency of complications. The patients treated with Pro-Guide had significantly fewer admission days and out-patient consultations. Larger randomized trials...

  15. Diagnostik og behandling af kvinder med urin-inkontinens på danske gynaekologiske afdelinger

    DEFF Research Database (Denmark)

    Vejtorp, M; Fischer-Rasmussen, W; Blaabjerg, J

    1990-01-01

    The routine practice in the diagnosis and treatment of urinary incontinence was investigated by means of a questionnaire to which all 32 departments replied. Miction charts were employed routinely in 17 departments and for selected patients in eight departments. Weighing of diapers was employed...... differences in the routine practices in Danish gynaecological departments in the diagnosis and treatment of utinary incontinence. This appears to be a suitable field for so called reference programmes....... in 13 departments for all patients investigated for incontinence, but only for selected patients in ten departments. Cystometry was employed in cases of stress-incontinence in 23 departments and in cases of urge-incontinence in 30 departments. As regards the choice of operative treatment, 22 departments...

  16. Sekundær prævention af apopleksi med effektiv antihypertensiv behandling

    DEFF Research Database (Denmark)

    Boye Knudsen, Signe; Strandgaard, Svend; Paulson, Olaf B

    2013-01-01

    In this meta-analysis, four of five placebo-controlled studies showed that antihypertensive treatment prevented stroke recurrence, most markedly in a study with a combination of an angiotensin-converting enzyme inhibitor and a diuretic. Studies with beta-blockers were not included. Two head......-to-head comparisons of a calcium antagonist and an angiotensin receptor antagonist showed no clear difference. Danish studies show that approximately 60% of patients with stroke are hypertensive one year after discharge from hospital. Antihypertensive treatment should be started or intensified in such patients....

  17. Sekundær prævention af apopleksi med effektiv antihypertensiv behandling

    DEFF Research Database (Denmark)

    Knudsen, Signe Boye; Strandgaard, Svend; Paulson, Olaf B.

    2013-01-01

    In this meta-analysis, four of five placebo-controlled studies showed that antihypertensive treatment prevented stroke recurrence, most markedly in a study with a combination of an angiotensin-converting enzyme inhibitor and a diuretic. Studies with beta-blockers were not included. Two head......-to-head comparisons of a calcium antagonist and an angiotensin receptor antagonist showed no clear difference. 
Danish studies show that approximately 60% of patients with stroke are hypertensive one year after discharge from hospital. Antihypertensive treatment should be started or intensified in such patients....

  18. Adjuverende medicinsk behandling tilpatienter med lokoregionalt recidiv af brystkræft

    DEFF Research Database (Denmark)

    Farooq, Farah Choudary; Kamby, Claus

    2016-01-01

    There is 10-30% risk of developing isolated locoregional recurrence (ILRR) after mastectomy for primary breast cancer. Currently, there is no standard treatment for ILRR and therefore patients with ILRR cause an oncological task. This review investigates existing literature concerning relevant ra...

  19. Omkostningseffektiv ændring af behandling ved delhudstransplantat på crus

    DEFF Research Database (Denmark)

    Vennegaard Kalialis, Louise; von Sperling, Marie Louise; Hoyer, A.P.

    2012-01-01

    We present a clinical comparison of short stretch bandage versus a two-layer compression bandage and early mobilization after split skin grafting to lower leg defects. A total of 38 patients were included. The first group were immobilized for four days and given a short stretch support bandage. G...

  20. Ballondilatation af det eustakiske rør er ny behandling til kronisk otitis media

    DEFF Research Database (Denmark)

    Møller, Martin Nue; Wanscher, Jens; Larsen, Per Leganger

    2014-01-01

    Balloon dilation of Eustachian tube is a novel method for managing chronic ventilatory dysfunction in patients with chronic otitis media, as an alternative to classic grommet insertion. Although few retrospective studies have been conducted the method seems to be rapid, simple and safe...

  1. Omkostningseffektiv ændring af behandling ved delhudstransplantat på crus

    DEFF Research Database (Denmark)

    Vennegaard Kalialis, Louise; von Sperling, Marie Louise; Høyer, Anette Pernille

    2012-01-01

    We present a clinical comparison of short stretch bandage versus a two-layer compression bandage and early mobilization after split skin grafting to lower leg defects. A total of 38 patients were included. The first group were immobilized for four days and given a short stretch support bandage...

  2. Liraglutids glukose- og vægtreducerende effekt ved behandling af type 2-diabetes

    DEFF Research Database (Denmark)

    Penninga, Ida Elisabeth Irene; Færch, Kristine; Almdal, Thomas

    2011-01-01

    Treatment with glucagon-like peptide-1 analogues including liraglutide is a new treatment option for patients with type 2 diabetes. Treatment with liraglutide decreases HbA1c by 1-2%, and additionally liraglutide has a reducing effect on weight, lipids and blood pressure. Most adverse events...

  3. Epilepsikirurgisk behandling af danske børn 1996-2002

    DEFF Research Database (Denmark)

    Uldall, Peter V; Nielsen, Hanne; Alving, Jørgen

    2002-01-01

    Epilepsy surgery is done in order to obtain seizure freedom or to reduce the number of epileptic seizures in selected patients not responding to medical treatment. Few Danish children have had this treatment, most probably because of some restrictions imposed by The Danish National Health Board. We...... present the results of the first 22 Danish children who have had epilepsy surgery....

  4. Diagnostik og behandling af kvinder med urin-inkontinens på danske gynaekologiske afdelinger

    DEFF Research Database (Denmark)

    Vejtorp, M; Fischer-Rasmussen, W; Blaabjerg, J

    1990-01-01

    The routine practice in the diagnosis and treatment of urinary incontinence was investigated by means of a questionnaire to which all 32 departments replied. Miction charts were employed routinely in 17 departments and for selected patients in eight departments. Weighing of diapers was employed...

  5. Laparoskopisk versus åben højresidig hemikolektomi til behandling af koloncancer

    DEFF Research Database (Denmark)

    Pommergaard, H C; Olsen, J.A.; Burgdorf, S.K.

    2010-01-01

    the Danish Colorectal Cancer Group (DCCG) database, we identified two groups each with 42 patients who underwent either laparoscopic right hemicolectomy (LRH) or open right hemicolectomy (ORH). The two groups were compared with respect to demographic data, length of hospital stay, number of glands harvested......INTRODUCTION: In Denmark, we are still debating whether a laparoscopic approach is beneficial for patients scheduled for right-sided hemicolectomy. The aim of this study was to compare the outcome of laparoscopic versus open resection for right-sided colon cancer. MATERIAL AND METHODS: Using...... to ORH with regards to morbidity, mortality and blood loss. Furthermore, LRH is associated with a shorter hospital stay and a higher radical lymph node harvest than ORH. The results and the thesis that LRH will result in fewer hernias and better cosmetic outcomes makes LRH a promising surgical procedure...

  6. Måltidet på hospitalet - Behandling eller bespisning af ældre

    OpenAIRE

    Røjel, Terkel Søndergaard

    2016-01-01

    The purpose of this master thesis is to examine the field of research with relevance to the topic geriatric malnutrition in order to propose recommendations that can stimulate the appetite, increase food intake, and stabilize the nutritional status of the geriatric patient at risk of malnutrition. For this purpose searches were conducted in the bibliographical databases: PubMed, PsycINFO and Sociological Abstracts along with various other resources. Based on these searches an analysis of the ...

  7. Overlevelse efter lynnedslag og behandling af tilstødende komplikationer

    DEFF Research Database (Denmark)

    Pedersen, Malene Lægdsgaard; Uslu, Bülent; Lind, Morten Nikolaj

    2011-01-01

    Lightning strike is an unpredictable weather phenomenon which can cause a variety of injuries to the human body. We present a case report with a 24-year-old male football player, who survived prolonged cardiac arrest after a lighting strike and then presented with multiple organ dysfunction due t...... to cellular swelling, extreme rhabdomyolysis and global hypoperfusion. We describe the clinical observations, therapy and injuries which may be expected. Furthermore, the pathophysiology and factors influencing the survival of this patient are discussed....

  8. Behandling af idiopatisk perifer facialisparese, også kaldet Bells parese

    DEFF Research Database (Denmark)

    Meyer, Martin Willy; Hahn, Christoffer Holst

    2013-01-01

    Bell's palsy is defined as an idiopathic peripheral facial nerve paralysis of sudden onset. It affects 11-40 persons per 100,000 per annum. Many patients recover without intervention; however, up to 30% have poor recovery of facial muscle control and experience facial disfigurement. The aim...... of this study was to make an overview of which pharmacological treatments have been used to improve outcomes. The available evidence from randomized controlled trials shows significant benefit from treating Bell's palsy with corticosteroids but shows no benefit from antivirals....

  9. Ny behandling af peritoneal karcinose fra kolorektal cancer. Cytoreduktiv kirurgi og hyperterm intraperitoneal kemoterapi

    DEFF Research Database (Denmark)

    Iversen, Lene Hjerrild; Rasmussen, Peter C; Laurberg, Søren

    2007-01-01

    Peritoneal carcinomatosis (PC) is commonly seen in colorectal cancer and is uniformly fatal. Cytoreductive surgery (CS) combined with hyperthermic intraperitoneal chemotherapy (HIIC) is a new treatment in strictly selected patients with PC. CS includes peritonectomy procedures and resection...... of infiltrated viscera leaving no macroscopic tumor thicker than 2.5 mm behind. Peritoneal perfusion with mitomycin C at a temperature of 40 degrees -41 degrees C is performed at the end of surgery. The postoperative morbidity and mortality rates are 20%-30% and 4%-8% respectively. Median survival is 1-2 years...

  10. Behandling af Dupuytrens kontraktur

    DEFF Research Database (Denmark)

    Raundrup Kornø, Maj; Søe, Niels Henrik; Dahlin, Lars B

    2015-01-01

    Dupuytren’s disease treatment Dupuytren’s disease is a hereditary fibroproliferative disease commonly affecting the palmar fascia of the hand, which results in progressive and irreversibly fixed flexion contractures of the hand. It may occur in the sole of the foot or in the penis. Gen­erally, tr......Dupuytren’s disease treatment Dupuytren’s disease is a hereditary fibroproliferative disease commonly affecting the palmar fascia of the hand, which results in progressive and irreversibly fixed flexion contractures of the hand. It may occur in the sole of the foot or in the penis. Gen...

  11. Korrekt behandling af forfrysninger

    DEFF Research Database (Denmark)

    El-Charnoubi, Waseem Ghulam; Bonde, Christian; Alsbjørn, Bjarne F

    2011-01-01

    Frostbite is rare in Denmark and is often associated with psychiatric conditions or drug- and alcohol abuse. It is seen regularly in countries with an arctic climate and tradition for outdoor activities such as skiing and climbing. The past winter in Denmark was long and cold, so we may see...

  12. Behandling af infantile spasmer

    DEFF Research Database (Denmark)

    Kjærsgård, Lars; Rasmussen, Niels

    2006-01-01

    Infantile spasms (IS) are characterised by neurodevelopmental regression, a unique type of seizures and a hypsarrhythmic EEG pattern. Studies recommend the medical treatment of IS as a positive short-term outcome with respect to the spasms and in the resolution of the hypsarrhythmia. However...

  13. Behandling af rolandisk epilepsi

    DEFF Research Database (Denmark)

    Miranda, Maria Jose; Ahmad, Banoo Bakir

    2017-01-01

    Recent literature indicates, that rolandic epilepsy/epilepsy of childhood with centrotemporal spikes may not be as benign as previously assumed. This study investigates the existing evidence, which describes the treatment effects on seizure frequency as well as improvement of cognition in children...... with rolandic epilepsy. We conclude, that treatment with anti-epileptic drugs could be justified, if treatment reduces seizures, prevents the evolution to atypical forms, or diminishes the negative cognitive consequences associated with the disease. Levetiracetam and sulthiame are the recommended treatments...

  14. Korrekt behandling af forfrysninger

    DEFF Research Database (Denmark)

    El-Charnoubi, Waseem Ghulam; Bonde, Christian; Alsbjørn, Bjarne F

    2011-01-01

    Frostbite is rare in Denmark and is often associated with psychiatric conditions or drug- and alcohol abuse. It is seen regularly in countries with an arctic climate and tradition for outdoor activities such as skiing and climbing. The past winter in Denmark was long and cold, so we may see...... this phenomenon more frequently in the future. We report two cases from the winter 2009/2010 and summarize the pathophysiology and briefly present the treatment strategy....

  15. Behandling af hypertermi

    DEFF Research Database (Denmark)

    Mørch, Sofie Søndergaard; Andersen, Johnny Dohn Holmgren; Bestle, Morten Heiberg

    2017-01-01

    Hyperthermia is an uncontrolled elevation of body temperature exceeding the body's ability to dissipate heat. Hyperthermia can result in dangerously high core temperatures and can rapidly become fatal. Common causes include heat stroke, malignant hyperthermia, serotonin syndrome, neuroleptic...... syndrome, a few endocrine emergencies as well as numerous intoxications. Rapid diagnosis and prompt cooling are pivotal, since the condition triggers a cascade of metabolic events which may progress to irreversible injury or death. Ice-water immersion and evaporative cooling are the methods of choice....

  16. Identitetskonstruktioner af patienter

    DEFF Research Database (Denmark)

    Lassen, Inger; Ottesen, Aase Marie; Strunck, Jeanne

    2015-01-01

    This paper focuses on patient identity in the Danish Health Act. Traditionally, the ideology of the welfare state has been based on equality and solidarity and the state has so far been responsible for the provision of health care services. Recent research suggests, however, that the implementation...... of New Public Management affects the welfare model and creates increasing inequality among citizens. These developments make it relevant to study how underlying ideologies may affect the construction of patient identity and health in the Danish welfare system. This would imply studying the role...... of identity at societal level, and in this paper we therefore ask whether the Danish Health Act constructs persons in need of care as vulnerable patients or as empowered citizens in line with recommendations by policy makers. The question we ask is whether the construction of patient identity in the Danish...

  17. Depressive patienters oplevelse af at modtage ECT

    DEFF Research Database (Denmark)

    Jensen, Christine Damsbo

    Dette studie handler om, hvordan det opleves for den voksne depressive patient at gennemgå et ECT-behandlingsforløb (electroconvulsive therapy). Formålet med projektet er dels at undersøge, hvordan processen omkring ECT-behandlingen udspiller sig og dels at undersøge patienternes oplevelse......, reaktioner og tanker omkring ECT-behandlingen. Studiet bygger på den eksisterende viden om patienters oplevelse af ECT. Metoden er feltforskning med deltagende observation og etnografisk interview. Dette suppleres af to spørgeskemaer. Der blev inkluderet 8 patienter i undersøgelsen. Analysen udspringer af...... konstruktivistisk epistemiologisk vinkel. Ved en teoristyret analyse fremkom 2 overordnede temaer: Anspændthed og tryghed. Disse temaer blev behandlet i en procesorienteret forståelse af ECT-forløbet. Denne proces bestod af: Betingelser, interaktion og konsekvenser. Diskussionen er en kritisk diskussion af fund og...

  18. Teknologiers mellemkomst i ambulant behandling og egenomsorg

    DEFF Research Database (Denmark)

    Ballegaard, Stinne Aaløkke; Aarhus, Rikke

    2009-01-01

    Vigtige tendenser i den danske sundhedssektor i disse år er centralisering af behandling og øget egenomsorg. Teknologi ses ofte som en del af denne udvikling, omend der eksisterer både dystopiske og utopiske forestillinger om, hvorvidt teknologi fremmedgør eller støtter patienten. I denne artikel...

  19. Behandling af demenssygdomme--hvem skal behandles?

    DEFF Research Database (Denmark)

    Hasselbalch, Steen; Kampmann, Jens Peter

    2009-01-01

    Recommendations for treatment with specific antidementia drugs in Denmark are given on the basis of recent evidence. Such evidence supports treatment of mild to moderate Alzheimer's Disease (AD) with acetylcholinesterase inhibitors (AchEI), and moderate to severe AD with memantine. Combination...... therapy with these drugs can be considered in moderate AD. Dementia with Lewy bodies and Parkinson's disease with dementia should be treated with rivastigmine. There is not sufficient evidence to recommend treatment with AchEI or memantine in pure vascular dementia or frontotemporal dementia...

  20. Behandling af demenssygdomme--hvem skal behandles?

    DEFF Research Database (Denmark)

    Hasselbalch, Steen; Kampmann, Jens Peter

    2009-01-01

    therapy with these drugs can be considered in moderate AD. Dementia with Lewy bodies and Parkinson's disease with dementia should be treated with rivastigmine. There is not sufficient evidence to recommend treatment with AchEI or memantine in pure vascular dementia or frontotemporal dementia......Recommendations for treatment with specific antidementia drugs in Denmark are given on the basis of recent evidence. Such evidence supports treatment of mild to moderate Alzheimer's Disease (AD) with acetylcholinesterase inhibitors (AchEI), and moderate to severe AD with memantine. Combination...

  1. Legionella pneumoni hos patienter, der er i behandling med infliximab

    DEFF Research Database (Denmark)

    Vinter, Hanne; Nielsen, Henrik Ib

    2009-01-01

    Therapy with tumour necrosis factor-alfa inhibitors is widely used in various inflammatory disorders, but adverse events from severe infections with intracellular pathogens may occur. We describe two cases of severe pulmonary legionellosis in patients treated with infliximab for Crohn's disease...

  2. Randomiseret klinisk undersøgelse af effekten af kognitiv adaptationstræning: design og metodediskussion

    DEFF Research Database (Denmark)

    Hansen, Jens Peter; Østergaard, Birte; Nordentoft, Merete

    2009-01-01

      Kognitiv adaptations træning er afprøvet gennem randomiserede studier i udlandet, men er ikke afprøvet på nydebuterede patienter, som modtager intensiv pleje og behandling. I denne artikel præsenteres et forskningsprojekt, som skal afgøre om kognitiv adaptations træning er velegnet i en dansk...... kontekst som supplement til nuværende tilbud til patienter med debuterende skizofreni. Studiet gennemføres som et randomiseret multicenter forsøg, hvor 164 konsekutivt inkluderede patienter fordeles til henholdsvis kognitiv adaptations træning og standardbehandling. Effekten af interventionen evalueres med......, fordelingsprocedure, bortfald, udvælgelse af patienter og sammenlignelighed mellem tilknyttede centre. Dette studie er det første studie, hvor kognitiv adaptations træning sammenlignes med et ambulant tilbud bestående af psykiatrisk behandling kombineret med hyppige hjemmebesøg ved distriktssygeplejersker. Studiet...

  3. Fysisk træning som behandling af nedsat funktionsevne hos svage, hjemmeboende 75+-årige

    DEFF Research Database (Denmark)

    Vad, Esther; Worm, Charlotte; Lauritsen, Jens

    2002-01-01

    The aim of this study was to establish the value of physical training as a treatment of reduced physical ability in frail, elderly patients living at home.......The aim of this study was to establish the value of physical training as a treatment of reduced physical ability in frail, elderly patients living at home....

  4. Hjertestop uden for hospital. Prospektiv undersøgelse af forskellige typer af udvidet præhospital behandling i Odense

    DEFF Research Database (Denmark)

    Nielsen, J R; Lybecker, H; Andersen, C

    1990-01-01

    by the Danish National Board of Health (6 months]. Out of 28 patients brought in by the medically staffed ambulance, two (7%) were discharged alive. Out of 57 patients brought in the phase with the motorized doctor nine (16%) were discharged alive. Out of 78 patients brought in by heart ambulance one (1...

  5. En krobjektiv lidelse? Forståelse og behandling af kroniske, diffuse smertelidelser med fibromyalgi som eksempel

    Directory of Open Access Journals (Sweden)

    Rie Lykke Danielsen

    2011-12-01

    Full Text Available The article deals with the disease field chronic diffuse pains, here exemplified by fibromyalgia, where patients are frequently rendered homeless in an objectivity focused medical treatment system, whose specialities (ideally seen are mutually exclusive, and where the absence of a diagnosis therefore poses a fundamental problem. In the treatment field there is, however, also a bio-psycho-social approach, and these two treatment regimes are respectively termed as a chrObjective approach and a holistic subject approach.By empirical examples, from stories by both therapists and patients, the article describes how the actors navigate between the two treatment regimes, to which the patients must necessarily adapt in their wish for acceptance and assistance from both sides. The authors further discuss to which degree the two treatment regimes are actually incompatible. The interviews and observation of participants, which constitute the empirical basis for the article, were carried out among therapists and patients in Denmark in 2010.

  6. Fortsat behov for både endovaskulær og åben kirurgisk behandling af abdominalt aortaaneurisme

    DEFF Research Database (Denmark)

    de la Motte, Louise; Jensen, Leif Panduro

    2012-01-01

    Abdominal aortic aneurysm can be treated by open surgical repair or by endovascular repair (EVAR) - a less invasive procedure, with lower 30-day mortality and morbidity rates. Twelve studies have been evaluated. The results indicate that for large aneurysms > 5.5 cm, EVAR can be recommended...... for patients with intermediate to high operative risk. For younger patients, with low operative risk, OR is the preferred method, in light of the continued small risk of rupture after EVAR and the need for lifelong surveillance....

  7. Behandling af renovaskulær hypertension med transluminal angioplastik--13 års erfaring--sekundærpublikation

    DEFF Research Database (Denmark)

    Øvrehus, Kristian Altern; Andersen, Poul Erik; Jacobsen, Ib Abildgaard

    2008-01-01

    angioplasty. A total of 124 patients were treated; 31% were normotensive immediately after angioplasty, 59% had improved blood pressure control and 10% had unchanged hypertension. The corresponding figures after six months and at the latest follow-up were 13, 72 and 15%. Udgivelsesdato: 2008-Jan-21......The result of treatment of renovascular hypertension by renal angioplasty over a period of 13 years was analysed. Patients with a positive diagnostic work-up with renography or renal vein renin measurement had renal angiography performed and in cases of renal artery stenosis, transluminal...

  8. Behandling med statiner medfører en øget risiko for udvikling af type 2-diabetes

    DEFF Research Database (Denmark)

    Solis, Anette Bratt; Pilemann-Lyberg, Sascha; Gæde, Peter

    2014-01-01

    Statins are important in the prevention of cardiovascular (CV) disease. However, they are associated with new-onset diabetes in a dose-dependent manner, particularly when the patient is already in risk of contracting diabetes. Meta-analyses estimate that the risk is increased by 9%. In absolute t...

  9. Behandling af defaekationsblokade som følge af dyb fossa recto-genitalis med total baekkenbundsrekonstruktion med Prolene-net

    DEFF Research Database (Denmark)

    Møller, P; Monrad, H; Kehlet, H

    1992-01-01

    The causes of severe defaecation blockage resulting from compression of the rectum and deep recto-genital fossa are reviewed and are illustrated by three patients who had previously undergone hysterectomy and who had incapacitating defaecation blockage and abdominal pain requiring morphine in two...... of the patients. The condition had not been diagnosed despite previous hospital contact for many years in two of the patients. Complete reconstruction of the pelvic floor with prolene net was performed. Subsequent defaecography showed normalization of defaecation without rectal compression and with relief...... of the abdominal pain and dependence on morphine in two of the patients. Rectal compression resulting from an abnormally deep recto-genital fossa should be included in the differential diagnostic deliberations in patients with severe constipation and defaecation blockage. Complete reconstruction of the pelvic...

  10. Patienters vurdering af medicinpakningernes indlaegssedler

    DEFF Research Database (Denmark)

    Horwitz, Anna; Reuther, Lene; Andersen, Stig Ejdrup

    2009-01-01

    effects had made them stop taking their medicine. Future studies should bring into focus the reason for medication adherence, how written information can be made easier to read, comprehensive and correct without contributing to anxiety and non-adherence. Udgivelsesdato: 2009-Feb......INTRODUCTION: The objective was to investigate patients' perception of patient information leaflets, including their readability, comprehensibility and their impact on adherence. MATERIAL AND METHODS: A 14-item questionnaire was prepared and answered by unselected patients in a general practice...... in Copenhagen. RESULTS: A total of 111 patients were included. Eighty-eight patients (79%) always or often read the patient information leaflets. Among these, 77% attached importance to adverse effects. A mere 13% attached importance to all leaflet information. In all, 21% never or rarely read patient...

  11. Kirurgisk behandling af cancer pancreatis

    DEFF Research Database (Denmark)

    Bergenfeldt, Magnus; Hansen, Carsten Palnaes; Mortensen, Michael Bau

    2010-01-01

    Surgery remains the only hope for cure in pancreatic cancer. The most common procedures are reviewed. Postoperative morbidity and mortality below 30% and 5%, respectively, are the standard. The benefit of extended lymph node dissection and portal-mesenteric vein resection is dubious. Selected pat...

  12. Diagnostik og behandling af trigeminusneuralgi

    DEFF Research Database (Denmark)

    Maarbjerg, Stine; Heinskou, Tone Bruvik; Wolfram, Frauke

    2016-01-01

    Trigeminal neuralgia (TN) is characterized by unilateral evoked short-lasting intense pain paroxysms in the face. A concomitant persistent background pain is frequently present. Neurovascular contact causing displacement or atrophy of the trigeminal nerve is important to TN aetiology. TN can also...

  13. Diagnostik og behandling af trigeminusneuralgi

    DEFF Research Database (Denmark)

    Maarbjerg, Stine; Heinskov, Tone Bruvik; Wolfram, Frauke

    2016-01-01

    Diagnostics and treatment of trigeminal neuralgia Trigeminal neuralgia (TN) is characterized by unilateral evoked short-lasting intense pain paroxysms in the face. A concomitant persistent background pain is frequently present. Neurovascular contact causing displacement or atrophy of the trigeminal...

  14. Korrekt behandling af akut akillesseneruptur

    DEFF Research Database (Denmark)

    Barfod, Kristoffer W; Ganestam, Ann; Madsen, Bjørn Lindegård

    2015-01-01

    to an increased risk of re-rupture and operative treatment to an increased risk of other complications such as adhesions, infection and nerve injury. When a non-operative treatment protocol is chosen it is paramount that sufficient expertise is present to guide the treatment and rehabilitation....

  15. Observation af kritisk syge patienter

    DEFF Research Database (Denmark)

    Fuhrmann, Lone; Hesselfeldt, Rasmus; Lippert, Anne

    2009-01-01

    The aim of this study was to estimate to which extent patients with abnormal vital signs on general wards had their vital signs monitored and documented and to establish if staff concern for patients influenced the level of monitoring and was predictive of increased mortality....

  16. Behandlingseffekt af Digital Dermatitis

    DEFF Research Database (Denmark)

    Krogh, Kenneth; Thomsen, Peter

    2008-01-01

    af klovlidelser herunder især Digital Dermatitis. Klovregistreringerne viser, at der er stor dynamik og mange nyinfektioner af Digital Dermatitis svarende til problematikken ved mastitis. Behandlingseffekten ved Digital Dermatitis er høj (omkring 90 %) ved den udførte behandling. Behandlingen bestod...

  17. Implementering af evidensbaseret praksis

    DEFF Research Database (Denmark)

    Scheel, Linda Schumann; Hansen, Ida Rode

    2014-01-01

    Projektet omhandler implementering af den kliniske retningslinje om identifikation, forebyggelse og behandling af delirium – i denne sammenhæng relateret til hjertepatienter. Projektet foregår på to hospitaler i Hjertecentret på Rigshospitalet, et intensivt afsnit og et sengeafsnit, i tæt...

  18. Implementering af evidensbaseret praksis

    DEFF Research Database (Denmark)

    Scheel, Linda Schumann; Tewes, Marianne; Petersen, Preben Ulrich

    2015-01-01

    Projektet omhandler implementering af den kliniske retningslinje om identifikation, forebyggelse og behandling af delirium – i denne sammenhæng relateret til hjertepatienter. Projektet foregår på to hospitaler i Hjertecentret på Rigshospitalet, et intensivt afsnit og et sengeafsnit, i tæt...

  19. Klinisk retningslinje for opsporing af angst og/eller depression hos indlagte og ambulante patienter med kronisk obstruktiv lungesygdom

    DEFF Research Database (Denmark)

    Strømstad, Grisja Vorre; Stassen, Ingelise Trosborg; Lassen Nielsen, Stine

    2015-01-01

    Formålet med den kliniske retningslinje er, at identificere screeningsredskaber der kan opspore angst og depression hos patienter med KOL, så patienter med angst og/eller depression bliver tilbudt relevant behandling....

  20. ARCgame - gamification af undervisning

    DEFF Research Database (Denmark)

    Jensen, Camilla Gyldendahl

    2014-01-01

    Gamification er et begreb, der anvendes til at beskrive brugen af spilelementer i andre miljøer for at forbedre brugernes oplevelse. Følgende tekst har til formål at behandle emnet i forhold til af opnå en forståelse for de elementer der indvirker på en ”gamification af et undervisningsforløb”, her...

  1. Gentaget selvmordsforebyggende behandling

    DEFF Research Database (Denmark)

    Lind, Bertel

    2014-01-01

    ramme er casestudie (Yin 2009; George 2005; Flyvbjerg 1991). Casestudiet består af en række patientforløb, hvor hver patient har haft mere end ét registreret behandlingsforløb i databasen (n = 377). Kvantitativ undersøgelse blev udført ved hjælp af Microsoft SPSS 21 på de 377 patienter på baggrund af...

  2. Psykomotorisk behandling og wellness til personer med demens

    DEFF Research Database (Denmark)

    Stamp, Anne Schinkel; Frausing, Kristian Park

    Rapporten evaluerer projektet Psykomotorisk behandling af personer med demens gennem fokusgruppeinterviews med deltagende studerende og personale fra deltagende centre. Samlet peges der på gavnligt udbytte for de demente beboere samt både personligt og fagligt udbytte for de deltagende studerende...

  3. Tilfredshedsundersøgelse af Palliativt Team Fyn

    DEFF Research Database (Denmark)

    Paulsen, Maja Skov

    2007-01-01

    Behandling af døende patienter i eget hjem kan være en vanskelig og udfor­ drende opgave. Målet med behand­ lingen skifter fra kurativt til lindrende, hvilket udfordrer selvopfattelsen som be­ handler, og samtidig vil palliativ behand­ ling ofte rumme komplicerede medicinsk faglige problemstillin...... problemstillinger samt eksisten­ tielle spørgsmål. Gennem de senere år er der etableret specialiserede palliative teams med udgående funktioner som støtte til de primære behandlere af dø­ ende mennesker....

  4. Midler til lindring af mundtørhed og stimulation af spytsekretion

    DEFF Research Database (Denmark)

    Dynesen, Anja Weirsøe; Pedersen, Anne Marie Lynge; Jensen, Allan Bardow

    2013-01-01

    Hvordan kan mundtørhed lindres og spytsekretion stimuleres? De eksisterende anbefalinger for behandling af mundtørhed og hyposalivation er i vid udstrækning empiriske, idet erfaringsgrundlaget fra randomiserede interventionsstudier af høj kvalitet er begrænset. Desuden er langtidseffekten af de f...

  5. Bernhard af Clairvaux. Teolog eller mystiker?

    DEFF Research Database (Denmark)

    Pedersen, Else Marie Wiberg

    En monografi om Bernhard af Clairvaux's teologi. Bogen er et opgør med at forstå Bernhard som mystiker, og forfatteren giver et grundigt indblik i Bernhards teologi ud fra hans egen kontekst. Bogen er den mest omfattende danske behandling af Bernhards teologi, og den viser, hvorfor han var det 12....... århundredes førende teolog i Europa....

  6. OPUS: Randomiseret multicenterundersøgelse af integreret behandling sammenlignet med standardbehandling før første psykoseepisode--sekundaerpublikation

    DEFF Research Database (Denmark)

    Nordentoft, Merete; Petersen, Lone; Jeppesen, Pia

    2006-01-01

    A total of 547 patients with first-episode psychosis were included in a randomised clinical trial comparing integrated treatment with standard treatment. The integrated treatment consisted of assertive community treatment with programmes for family involvement and social skills training. Patients...

  7. Træning har positiv effekt på helbredsrelateret livskvalitet hos kræftpatienter i behandling--en gennemgang af et Cochranereview

    DEFF Research Database (Denmark)

    Lønkvist, Camilla Kjær; Højman, Pernille; Gehl, Julie

    2013-01-01

    Cancer and treatment of cancer affects the health-related quality of life (HRQoL) in patients. A recent Cochrane review concludes that exercise may have positive effects on HRQoL and several other domains. Other reviews have shown that physical activity may protect against development of cancer a...

  8. Kirurgisk behandling af cancer ventriculi på et universitetshospital. En retrospektiv opgørelse for perioden 1990-1995

    DEFF Research Database (Denmark)

    Hillingsø, Jens; Hviid, Kirsten; Mynster, T

    2001-01-01

    AIM: A retrospective study of 69 cases of gastric cancer seen during the period from 1/1-1990 to 31/12-1994 treated in a University Hospital. The aim of the study was to describe morbidity, mortality and identify independent prognostic variables for mortality. METHOD: Patient data were recovered ......, operative technique and the necessary routine for the surgeons. All gastric ulcers must be considered malignant and biopsies taken accordingly....

  9. Kirurgisk behandling af cancer ventriculi på et universitetshospital. En retrospektiv opgørelse for perioden 1990-1995

    DEFF Research Database (Denmark)

    Hillingsø, Jens; Hviid, Kirsten; Mynster, T

    2001-01-01

    AIM: A retrospective study of 69 cases of gastric cancer seen during the period from 1/1-1990 to 31/12-1994 treated in a University Hospital. The aim of the study was to describe morbidity, mortality and identify independent prognostic variables for mortality. METHOD: Patient data were recovered.......001) as independent variables. DISCUSSION: The overall five-year survival is low and has not changed over two decades in Denmark, whereas mortality and morbidity rates have improved. It should be recommended that: The treatment of gastric cancer must be centralised in order to develop preoperative examinations...

  10. Patients' Obligation, Embodiment, Motives, and Self in Hypertension - a Qualitative Study from General Practice (PhD thesis)

    DEFF Research Database (Denmark)

    Sångren, Henrik

    Resume: Afhandlingen besk‘ftiger sig med hvordan patienter oplever at blive diagnosticeret med forh›jet blodtryk (hypertension). Unders›gelsen unders›ger hvilke motiver der bev‘ger patienter til at acceptere medicinsk behandling af deres forh›jede blodtryk, og hvorledes de oplever livet med hyper...

  11. International trends in clinical characteristics and oral anticoagulation treatment for patients with atrial fibrillation: Results from the GARFIELD-AF, ORBIT-AF I, and ORBIT-AF II registries

    NARCIS (Netherlands)

    Steinberg, B.A.; Gao, H.; Shrader, P.; Pieper, K.; Thomas, L.; Camm, A.J.; Ezekowitz, M.D.; Fonarow, G.C.; Gersh, B.J.; Goldhaber, S.; Haas, S.; Hacke, W.; Kowey, P.R.; Ansell, J.; Mahaffey, K.W.; Naccarelli, G.; Reiffel, J.A.; Turpie, A.; Verheugt, F.W.; Piccini, J.P.; Kakkar, A.; Peterson, E.D.; Fox, K.A.

    2017-01-01

    Atrial fibrillation (AF) is the most common cardiac arrhythmia in the world. We aimed to provide comprehensive data on international patterns of AF stroke prevention treatment. METHODS: Demographics, comorbidities, and stroke risk of the patients in the GARFIELD-AF (n=51,270), ORBIT-AF I (n=10,132),

  12. Risikostratificering af patienter med diabetes mellitus

    DEFF Research Database (Denmark)

    Qvist, Peter; Glintborg, Dorte; Andries, Alin

    2008-01-01

    with diabetes mellitus. MATERIAL AND METHODS: We included patients with diabetes from the catchment areas of four diabetes out-patient clinics in southern Denmark. Patients were risk-stratified to 3 follow-up levels (level 1 - follow-up only by their GP, level 2 - intensified follow-up by GP and/or shared care...... schemes, level 3 - follow-up only in out-patient clinics). The results were subsequently compared with the patients' actual follow-up status. RESULTS: A total of 647 patients (563 type 2 diabetes and 84 type 1 diabetes) were included from 15 GPs. Among these, 139 were stratified to level 1, 409 to level 2...

  13. Rehabilitering af patienter med erhvervet hjerneskade

    DEFF Research Database (Denmark)

    Rasmussen, Anne Almskou; Jørgensen, Henrik Stig; Nielsen, Jørgen Feldbæk

    2014-01-01

    the needs of patients with the most severe ABIs. Only recently rehabilitation of patients with ABI has been anchored in the medical specialty of neurology. Since then the development has taken an up-going curve. This process has been supported by The Danish Health and Medicines Authority publishing several......In Denmark the development of rehabilitation of patients with acquired brain injury (ABI) has differed from most parts of Europe. Denmark has no medical rehabilitation specialty. In 2000 two specialized hospital units were established to serve the population of 5.7 million inhabitants. They cover...... papers that highlights evidence-based organization and interventions. Current development aim to define: 1) skills of the medical doctor engaged in the rehabilitation of patients with ABI, 2) stratification to different levels of specialization at hospital and in the community, and 3) national guidelines...

  14. Kirurgisk behandling af urininkontinens hos kvinder

    DEFF Research Database (Denmark)

    Ammendrup, A.C.; Sørensen, Helle Christina; Sander, Pia

    2010-01-01

    (TVT) was the preferred sling in 2006. A total of 20 (47%) UI surgeons used only TVT, seven (17%) only transobturator slings (TOS) and 15 (36%) both TVT and TOS. Only 11 (24%) performed > 25 TVT per year and 11 (27%) performed > 25 TOS per year. In all, UI surgeons had experience with ten different...

  15. Diagnostik og behandling af pruritus ani

    DEFF Research Database (Denmark)

    Thomsen, Simon Francis; Larsen, Helle Kiellberg; Hagen, Kikke

    2009-01-01

    Pruritus ani is defined as an intense itching sensation affecting the perianal skin. The condition affects up to 5% of the population, and occurs four times more commonly in men than in women. Pruritus ani occurs in a primary form caused by overt but insufficient cleansing of the perianal skin...

  16. Diagnostik og behandling af benigne levertumorer

    DEFF Research Database (Denmark)

    Eriksen, Peter Lykke; Schultz, Nicolai Aagaard; Larsen, Lars P.S.

    2016-01-01

    Due to the expanding use of diagnostic imaging, an increasing number of liver tumours are discovered. Benign tumours are very common; they rarely cause symptoms and often they do not require any treatment. However, because of differences in the natural history including risk of complications...... and malignant transformation exact diagnosis is important. Dedicated radiological examinations serve as important diagnostic tools reducing the need for biopsy. In this review we provide an update on the diagnosis and treatment of benign liver tumours adding to existing recommendations on hepatocellular...

  17. Kirurgisk behandling af midt og lav rectumcancer

    DEFF Research Database (Denmark)

    Bjørn, Maya Xania; Perdawood, Sharaf Karim

    2017-01-01

    -assisted TME may overcome the technical difficulties and shows comparable oncological results, yet it is associated with significant additional costs. Transanal TME is a promising method which seems to overcome the technical and financial issues of the other techniques, without compromising the short......Total mesorectal excision (TME) is standard treatment of mid- and low rectal cancer and has evolved with minimally invasive surgery. Laparoscopic TME has proven to be technically challenging, and recent randomized controlled studies fail to prove it oncologically superior to open TME. Robotic...

  18. Impotens forarsaget af behandling med methotrexat

    DEFF Research Database (Denmark)

    Penninga, Ida Elisabeth Irene; Larsen, H.K.; Andersen, S.E.

    2008-01-01

    impotence nine months after initiation of treatment. Two weeks after discontinuation of MTX the impotence subsided, but when MTX treatment was reintroduced, the impotence returned after two months. Only a few other cases of impotence associated with MTX have been described previously Udgivelsesdato: 2008/1/28...

  19. MINDFULNESS BEHANDLING AF DANSKE VETERANER - ET PILOTSTUDIE

    DEFF Research Database (Denmark)

    Fjorback, Lone

    2015-01-01

    I foråret 2014 mødtes en gruppe på 12 danske veteraner en gang om ugen i 9 uger for at deltage i programmet Mindfulness Baseret Stress Reduktion (MBSR). Deltagerne havde meldt sig frivilligt, og gruppen var blandet mht. alder, køn, antal udsendelser og diagnoser. Det, de havde til fælles, var...

  20. Radiologisk diagnostik og behandling af akut cholecystitis

    DEFF Research Database (Denmark)

    Arsic, Ivan; Abrahamsen, Jan; Gammelgård, Lise

    2017-01-01

    Acute cholecystitis (AC) it to 90% caused by stones in the gall bladder. The most predominant symptom of AC is pain localized to the upper right quadrant of the abdominal wall associated with fever, leucocytosis and a rise in CRP. Although cholescintigraphy has the highest sensitivity (97...

  1. Behandling af peritonsillær absces

    DEFF Research Database (Denmark)

    Anthonsen, Kristian; Trolle, Waldemar

    2012-01-01

    Peritonsillar abscess (PTA) is associated with high morbidity and can cause serious and life-threatening complications. In Denmark, the most commonly isolated bacteria are Fusobacterium necrophorum and Streptococcus pyogenes gr. A. The incidence of PTA in Denmark is 41/100,000/year, the highest...

  2. Abatacept til behandling af reumatoid artritis

    DEFF Research Database (Denmark)

    Nielsen, Henrik; Hansen, Annette

    2009-01-01

    Abatacept (CTLA4Ig) is a human fusion protein which consists of a cytotoxic lymphocytic-associated type 4 antigen which is bound to the Fc part of the IgG1. Abatacept binds to CD80/CD86 on antigen-presenting cells thus blocking the co-stimulatory signal to the naïve T cells and interfering with a...

  3. Kirurgisk behandling af type 2-diabetes

    DEFF Research Database (Denmark)

    Olesen, Stine Chabert; Hansen, Dorte Lindqvist; Almdal, Thomas

    2009-01-01

    The resolution of diabetes after gastric bypass is already observed during the first days after the operation, while the control of diabetes after gastric banding occurs after weight loss. Other mechanisms than weight loss must therefore explain the improved glucose tolerance. Focus has been on a...... with the aim of curing type 2-diabetes are warranted. Udgivelsesdato: 2009-Feb-16...

  4. Ny behandling af kronisk hepatitis B

    DEFF Research Database (Denmark)

    Andersen, Ellen Sloth; Weis, Nina M

    2008-01-01

    Worldwide, 350 million people are infected with chronic hepatitis B. Over the last few years, it has been possible to treat chronic hepatitis B. Treatment very often consists of nucleos(t)ide analogs and in a few cases of pegylated alpha-interferon. In 2007, a new nucleoside analog, Telbivudine......, was approved to treat chronic hepatitis B. In phase II and ongoing phase III studies, Telbivudine has proven more effective than the nucleoside analog, Lamivudine, which was very often used up until recently. Udgivelsesdato: 2008-Nov-24...

  5. Smitteopsporing og profylaktisk behandling af tuberkulose

    DEFF Research Database (Denmark)

    Seersholm, Niels; Wilcke, Torgny

    2011-01-01

    Contact tracing is an integrated part on tuberculosis management and is conducted by the medical officer in collaboration with the local chest clinics. The principle of contact tracing is to begin with the household contacts and expanding to more peripheral contacts depending of the number...

  6. Kirurgisk behandling af type 2-diabetes

    DEFF Research Database (Denmark)

    Olesen, Stine Chabert; Hansen, Dorte Lindqvist; Almdal, Thomas

    2009-01-01

    on appetite-regulating gut hormone, particularly peptide YY and glucagon-like peptide-1. Nevertheless, other unknown hormones or mechanisms may be involved in the dramatic changes in the glucose metabolism. Development of new drugs and treatments based on the endocrine changes observed after bariatric surgery...

  7. Diagnostik og behandling af akut colonpseudoobstruktion

    DEFF Research Database (Denmark)

    Ertberg, Pia; Vilandt, Jesper; Bødker, Birgit

    2013-01-01

    Acute colonic pseudo-obstruction (ACPO), also known as Ogilvie's syndrome, is a clinical condition with acute dilatation of the colon without a provable mechanical cause. Early recognition and treatment of the condition is important in order to improve the outcome. The diagnosis is based...

  8. Kirurgisk behandling af aldersrelateret makuladegeneration (AMD)?

    DEFF Research Database (Denmark)

    Kiilgaard, Jens Folke

    2001-01-01

    oftalmologi, aldersrelateret makuladegeneration, transplantation, grise, øjne, kirurgisk udvikling......oftalmologi, aldersrelateret makuladegeneration, transplantation, grise, øjne, kirurgisk udvikling...

  9. Kirurgisk behandling af urininkontinens hos kvinder

    DEFF Research Database (Denmark)

    Ammendrup, A.C.; Sørensen, Helle Christina; Sander, Pia

    2010-01-01

    . MATERIAL AND METHODS: Surgeons performing UI procedures were identified and mailed a questionnaire in 2007 concerning 2006. Questions included specialisation, number of procedures, type of surgery, complications and attitude towards learning surgery and maintaining a sufficient level of routine. RESULTS...... slings. This study did not allow for a quantitative assessment of complications. The attitude was that 10-25 operations are needed to learn the procedure, and that > 10 operations per year are needed to maintain a sufficient level of routine. CONCLUSION: Practice and attitudes among urinary incontinence......INTRODUCTION: During the last decade, minimal invasive procedures have been introduced for treatment of urinary incontinence (UI) in women leading to shorter hospitalisation and fewer complications. The aim of this study was to outline clinical practice and attitudes among Danish UI surgeons...

  10. Ny behandling af kronisk hepatitis B

    DEFF Research Database (Denmark)

    Andersen, Ellen Sloth; Weis, Nina M

    2008-01-01

    Worldwide, 350 million people are infected with chronic hepatitis B. Over the last few years, it has been possible to treat chronic hepatitis B. Treatment very often consists of nucleos(t)ide analogs and in a few cases of pegylated alpha-interferon. In 2007, a new nucleoside analog, Telbivudine, ...

  11. Udredning og behandling af morbus Osler

    DEFF Research Database (Denmark)

    Kjeldsen, Anette Drøhse; Andersen, Poul Erik; Tørring, Pernille Mathiesen

    2011-01-01

    Morbus Osler or hereditary haemorrhagic telangiectasia (HHT) is a genetic disorder resulting in development of arteriovenous malformations in the mucosa and in visceral organs. The most common symptom is epistaxis. The disease may, however, cause a variety of other serious manifestations such as ......Morbus Osler or hereditary haemorrhagic telangiectasia (HHT) is a genetic disorder resulting in development of arteriovenous malformations in the mucosa and in visceral organs. The most common symptom is epistaxis. The disease may, however, cause a variety of other serious manifestations...

  12. Forskning i ergoterapeutisk behandling indenfor neurorehabilitering - en stor udfordring og nødvendighed!

    DEFF Research Database (Denmark)

    Schow, Trine

    2011-01-01

    Der sker i disse år meget indenfor både forskning og behandling i neurorehabilitering. Både grundforskning og kliniske studier bidrager til viden om neuroplasticitet og til udvikling og dokumentation af forskellige behandlingsformer og det er vigtigt at det ergoterapeutiske felt følger med. Denne...

  13. Postoperativ smertebehandling af ældre patienter

    DEFF Research Database (Denmark)

    Friesgaard Christensen, Kristian; Nikolajsen, Lone

    2013-01-01

    The management of post-operative pain in the elderly represents a challenge due to coexisting diseases, concurrent medications, and age-related pharmacodynamic and pharmacokinetic changes. Analgesic therapy in this group of patients should balance the potential efficacy with the risk...... of interactions and side effects. In general, doses should be smaller and the dosing intervals longer ("start low and go slow") and the use of regional blocks and non-pharmacological treatment should be encouraged. Continuous assessment of pain, pain relief and side effects is particularly important in elderly...

  14. An adherent nerve root – Classification and exercise therapy in a patient diagnosed with lumbar disc prolapse

    DEFF Research Database (Denmark)

    Melbye, Martin

    2010-01-01

    Patienter med diskusprolaps får oftest besked på, at det ikke skal gøre ondt for at gøre godt, i forbindelse med behandling og genoptræning. Der findes dog en ganske lille gruppe patienter som udvikler en restriktiv tilstand, hvor der dannes adhærencer ved nerveroden, i forbindelse med opheling a...... prolapsen. Tilstanden remodelleres med smertefulde hjemmeøvelser som gradvist progredieres over nogle måneder. En ny case-rapport i Manual Therapy dokumenterer fysioterapidiagnostik, klinisk ræsonnering og behandling af en patient med denne lidelse. Udgivelsesdato: 2010...

  15. Diabetisk ketoacidose hos en hiv-positiv patient i antiretroviral behandling

    DEFF Research Database (Denmark)

    Holm, Malene Rahbek; Hansen, Birgitte Rønde; Røder, Michael E

    2006-01-01

    Following the introduction of highly active antiretroviral therapy (HAART), a number of metabolic and morphologic alterations, known as HIV-associated lipodystrophy syndrome (HALS), have been increasingly common in HIV-infected patients being treated with this therapy. The use of protease inhibit...

  16. Evaluering af ordning med psykologbehandling af personer med let til moderat depression

    DEFF Research Database (Denmark)

    Fjeldsted, Rita; Christensen, Kaj Sparle

    tidligere evaluering af forsøgsordning af psykologbehandling af depression i perioden 2005-06. 18.419 personer i alderen 18-37 år blev henvist til psykolog i den undersøgte ordning i perioden 1.2.2009 – 31.1.2010, svarende til en henvisningshyppighed på 1,6 % af baggrundsbefolkningen i samme aldersgruppe...... samme niveau som fandtes i evalueringen fra 2007. Remissionsraten for personer med depression ved behandlingsstart er 87 % målt med MDI. Patienters selvrapporterede effekt er 95 %. I opfølgningsgruppen har 89 % ingen depression 3 år efter afsluttet behandling, 56 % har oplevet mindst én ny...... for begge køn, og der ses et fald på 40 % for kvinder og 70 % for mænd over de givne 3 år. Tidsperspektivet er for denne gruppe mere relevant for overordnet vurdering, men der savnes en sammenligningsgruppe. Ifølge spørgeskemadata øges andelen af personer, der er i arbejde, selvforsørgelse eller på SU fra...

  17. Serumelektrolytter og medikamentel behandling hos patienter indlagt på en geriatrisk afdeling

    DEFF Research Database (Denmark)

    Sørensen, I J; Matzen, L E

    1993-01-01

    The distributions of sodium and potassium in the serum on admission, and the types of medicine used were studied retrospectively in hospitalized geriatric patients (n = 1418). Sodium concentrations below 130 mmol/l were found in 7.4% and potassium concentrations below 3.0 mmol/l in 5.0% of patien......+amiloride was frequently withdrawn. 38% were given benzodiazepines on discharge. In 40.4% of these, treatment had been started during the hospital stay, most often on account of insomnia. Udgivelsesdato: 1993-Nov-29....... Risk factors for low sodium concentrations were treatment with the combination of thiazide+amiloride, potassium-sparing diuretics, thiazides, emergency hospitalization and low body weight. Risk factors for low potassium concentrations were treatment with the combination of thiazide+amiloride, thiazides...... and female gender. On an average, patients were given two different drugs from specified groups both on admission and on discharge, but changes in medical treatment were often performed during the hospital stay. Prehospital treatment with thiazide diuretics and the combination of thiazide...

  18. Røveri af bil - forbrydelsen der ikke findes

    DEFF Research Database (Denmark)

    Lentz, Lene Wacher

    2018-01-01

    Artiklen behandler den særegne strafferetlige problematik, at røveri af bil ikke straffes som sådan, men alene som ulovlig tvang og brugstyveri. Dette skyldes en formodning om, at tyven kun vil bruge bilen, ikke tilegne sig bilen. Konsekvensen bliver en langt lavere straf for "røveri af bil", end...

  19. Sparring på evaluering af Destination Trivsel

    DEFF Research Database (Denmark)

    Schulz, Anette

    , konklusion – hvor udsagn fra elever i henholdsvis indskolingen, mellemtrinnet og udskolingen indledningsvist behandles separat og deskriptivt. Efterfølgende er data analyseret med afsæt i en kryds-case-analyse, hvor der på baggrund af den deskriptive analyse koblet til de respektive målgrupper er udledt en...

  20. Skandinaviske kliniske retningslinjer for præhospital behandling af patienter med svære hovedtraumer

    DEFF Research Database (Denmark)

    Juul, Niels; Sollid, Snorre; Sundstrøm, Terje

    2008-01-01

    . Evidence-based guidelines already exist that focus on all steps in the management. This article, which was written by members of the Scandinavian Neurotrauma Committee, presents recommendations on the pre-hospital management of traumatic brain injury adapted to the infrastructure of Scandinavia...

  1. Valg af behandling af akut, purulent divertikulitis er uafklaret

    DEFF Research Database (Denmark)

    Hupfeld, Line; Burcharth, Jakob; Pommergaard, Hans-Christian

    2015-01-01

    Inflammation in colonic diverticula can develop into acute diverticulitis. Treatment varies depending on illness severity. Perforated diverticulitis with faecal peritonitis is treated surgically and Hartmann's procedure is the preferred operation. Peritoneal lavage might be an alternative...

  2. Hospitalizations in patients with atrial fibrillation: an analysis from ROCKET AF

    Science.gov (United States)

    DeVore, Adam D.; Hellkamp, Anne S.; Becker, Richard C.; Berkowitz, Scott D.; Breithardt, Guenter; Hacke, Werner; Halperin, Jonathan L.; Hankey, Graeme J.; Mahaffey, Kenneth W.; Nessel, Christopher C.; Singer, Daniel E.; Fox, Keith A. A.; Patel, Manesh R.; Piccini, Jonathan P.

    2016-01-01

    Abstract Aims The high costs associated with treatment for atrial fibrillation (AF) are primarily due to hospital care, but there are limited data to understand the reasons for and predictors of hospitalization in patients with AF. Methods and results The ROCKET AF trial compared rivaroxaban with warfarin for stroke prophylaxis in AF. We described the frequency of and reasons for hospitalization during study follow-up and utilized Cox proportional hazards models to assess for baseline characteristics associated with all-cause hospitalization. Of 14 171 patients, 14% were hospitalized at least once. Of 2614 total hospitalizations, 41% were cardiovascular including 4% for AF; of the remaining, 12% were for bleeding. Compared with patients not hospitalized, hospitalized patients were older (74 vs. 72 years), and more frequently had diabetes (46 vs. 39%), prior MI (23 vs. 16%), and paroxysmal AF (19 vs. 17%), but less frequently had prior transient ischaemic attack/stroke (49 vs. 56%). After multivariable adjustment, lung disease [hazard ratio (HR) 1.46, 95% confidence interval (CI) 1.29–1.66], diabetes [1.22, (1.11–1.34)], prior MI [1.27, (1.13–1.42)], and renal dysfunction [HR 1.07 per 5 unit GFR < 65 mL/min, (1.04–1.10)] were associated with increased hospitalization risk. Treatment assignment was not associated with differential rates of hospitalization. Conclusion Nearly 1 in 7 of the moderate-to-high-risk patients with AF enrolled in this trial was hospitalized within 2 years, and both AF and bleeding were rare causes of hospitalization. Further research is needed to determine whether care pathways directed at comorbid conditions among AF patients could reduce the need for and costs associated with hospitalization. PMID:27174904

  3. Tuberkulose forårsaget af Mycobacterium africanum

    DEFF Research Database (Denmark)

    Bek, Dorte; Kjeldsen, Marianne Kirstine; Hansen, Nikolaj Friis

    2010-01-01

    Tuberkulose (TB) forårsages af patogene arter fra Mycobacterium tuberculosis komplekset (MTBC) og har en incidens på cirka 7/100.000 i Danmark. På mistanke om TB hos en akut indlagt 40 årig afrikansk mand initieredes anti-TB behandling. Efter 13 timers indlæggelse afgik patienten ved døden. Fra...

  4. Håndtering af illikviditet i APV modellen

    DEFF Research Database (Denmark)

    Brandt, Mads; Dalgaard, Rune; Plenborg, Thomas

    2014-01-01

    Denne artikel behandler illikviditetspræmien i forbindelse med værdiansættelser. Mere præcist udledes den korrektion af illikviditetspræmien, der skal foretages, for at sikre konsistens i værdiansættelsen med henholdsvis Discounted Cash Flow (DCF) og Adjusted Present Value (APV) modellen. Artiklen...

  5. Review af Business Process Reengineering litteraturen fra 1990-98

    DEFF Research Database (Denmark)

    Wit, Camilla Kølsen de

    1998-01-01

    Formålet med papiret er dels at biddrage med et overblik over centrale kilder om BPR, og dels at kommentere udviklingen i litteraturens behandling af hhv. BPR begrebet og BPR projektet. Reviewet er bygget op om en kronologisk tabel, der opsummerer kildernes hovedsynspunkter....

  6. Rivaroxaban in patients with atrial fibrillation: from ROCKET AF to everyday practice.

    Science.gov (United States)

    Barón-Esquivias, Gonzalo; Marín, Francisco; Sanmartín Fernandez, Marcelo

    2017-05-01

    Registries and non-interventional studies offer relevant and complementary information to clinical trials, since they have a high external validity. Areas covered: The information regarding the efficacy and safety of rivaroxaban compared with warfarin, or rivaroxaban alone in clinical practice was reviewed in this manuscript. For this purpose, a search on MEDLINE and EMBASE databases was performed. The MEDLINE and EMBASE search included both medical subject headings (MeSH) and keywords including: atrial fibrillation (AF) OR warfarin OR clinical practice OR ROCKET AF AND rivaroxaban. Case reports were not considered. Expert commentary: In ROCKET AF, rivaroxaban was at least as effective as warfarin for the prevention of stroke in patients with nonvalvular AF at high risk of stroke, but, importantly, with a lesser risk of intracranial, critical and fatal bleedings. A number of observational comparative and non-comparative studies, with more than 60,000 patients included treated with rivaroxaban, have analyzed the efficacy and safety of rivaroxaban in real-life patients with AF in different clinical settings. These studies have shown that in clinical practice, rates of stroke and major bleeding were consistently lower than those reported in ROCKET AF, likely due to the lower thromboembolic and bleeding risk observed in these patients.

  7. Faktorer af betydning for tidlig og sen indlaeggelse af patienter med apopleksi og transitorisk cerebral iskaemi

    DEFF Research Database (Denmark)

    Rasmussen, Berit H; Germer, Ulla; Kammersgaard, Lars Peter

    2003-01-01

    predictors of early admission. DISCUSSION: Patients with stroke or TIA in a Danish metropolitan area arrive at hospital a median of 2.6 hours after the stroke. Admission by ambulance after calling emergency was associated with the shortest onset to admission time. Udgivelsesdato: 2003-Jan-13...

  8. Brug af nervestimulator ved anlaeggelse af nervus ischiadicus-blokade hos en crusamputeret patient

    DEFF Research Database (Denmark)

    Heiring, Christian; Kristensen, Billy B

    2008-01-01

    We present a case of a sciatic nerve block performed with the nerve stimulation technique. This technique is normally not used in amputees because detection of a motor response to an electrical stimulation is impossible. In our patient the stimulation provoked a phantom sensation of movement...

  9. How do Patients Experience Consultations in an Outpatient AF-clinic?

    DEFF Research Database (Denmark)

    Thrysøe, Lars

    over time? (Phase II) What economic consequences can be derived from the AF-clinic? (Phase III) Methods The first research question (Phase I) includes 14 patients, and will be answered by fieldwork and interviews. Afterwards, the ongoing Phase II includes 150 patients who reply the same questionnaire...... three times over a period of one year. Phase III will be answered through register-based research. Results The abstract describes results from Phase I. The patients were unsure what was going to happen during consultations and they have almost no information from GP about AF. The information...... at the first consultation by the physician was overwhelmingly, and thereby difficult for the patients to be involved in decision-making and to remember afterwards. Several of the patients expressed fear of dyeing before first consultation and were calm knowing it was not going to happen because of AF...

  10. Relationship of plasma level of NT- ProBNP with development of AF in CABG patients

    Directory of Open Access Journals (Sweden)

    Tanaray B

    2010-10-01

    Full Text Available "nBackground: Studies of the association between post operative AF and Plasma level of NT- Pro BNP have reported conflicting findings. The aim of the present study was evaluation of the association between post coronary bypass graft- Atrial Fibrillation (AF and Plasma level of NT- ProBNP as an independent risk factor of AF development in patients undergoing coronary artery bypass graft."n "nMethods: In a cohort study, 79 patients with sinus rhythm who admitted in Imam Khomeini Hospital in Tehran, Iran, during February 2009 and February 2010 for CABG are included the study and followed for developing post operative AF rhythm."n "nResults: Post operative AF was found in 17.7% of patients. The peak time from the operation to the first AF episode was in second post op day in ten patients (71.4%. The serum level of ProBNP in patients with AF was significantly higher (1624± 647 versus 221± 238 pg/ml, p< 0/0001. Increased age, Increased LA size and high plasma level of ProBNP were associated with increased risk for post op AF. After adjustment of risk factors, plasma level of ProBNP was the most important risk factor with odds ratio of 15.34 with CI 95% 1.77-132.95 and then LA diameter with odds ratio of 6.11 with CI 95% 0.99-37.42 was independently correlated with post op AF. Correlation between plasma level of ProBNP with age and LA size was seen too (LA size r = 0.0281, p= 0.012. Between age and ProBNP (r= 0.337, p= 0.002. The best cut off point for plasma ProBNP as a predictor of post op AF was 854 pg/ml."n "nConclusion: Increased level of preoperative ProBNP levels could be an independent predictor of post operative Atrial Fibrillation.

  11. Mediernes ret til at offentliggøre billeder af offentligt kendte personer efter von Hannover nr. 2

    DEFF Research Database (Denmark)

    Riis, Thomas; Udsen, Henrik; Borberg, Vibeke

    2015-01-01

    Artiklen er baseret på en analyse af den Europæiske Menneskerettighedsdomstols dom i den anden sag vedrørende prinsesse Caroline von Hannover af Monaco, som gennem mange år har forsøgt at beskytte sit privatliv mod eksponering i ugebladspressen (von Hannover nr. 2). Artiklen behandler også spørgs...

  12. Fremlæggelse af projekt med Epworth søvnighedsskema, opgørelse af data fra 2009-2014: "Prevalence of excessive daytime sleepiness in patients treated with orthognathic surgery"

    DEFF Research Database (Denmark)

    Linderup, Mette Werner

    Fremlæggelse af projekt med Epworth søvnighedsskema, opgørelse af data fra 2009-2014: "Prevalence of excessive daytime sleepiness in patients treated with orthognathic surgery"......Fremlæggelse af projekt med Epworth søvnighedsskema, opgørelse af data fra 2009-2014: "Prevalence of excessive daytime sleepiness in patients treated with orthognathic surgery"...

  13. Klimavenlig majs ved minimal tilførsel af kvælstof

    OpenAIRE

    Ambus, Per

    2009-01-01

    Majs-biomasse kan omdannes til klimavenlig CO2-neutral energi ved behandling til bioetanol og biogas. Men gødskes majsen med affaldet fra biogasanlægget, dannes der betragtelige mængder af den kraftige drivhusgas, lattergas. Herved reduceres klimagevinsten mærkbart. Dyrkning af majs til energiformål skal derfor ske med ingen eller lille tilførsel af N.

  14. Progression of atrial fibrillation after catheter ablation procedure and antiarrhythmic drug therapy in patients with paroxysmal AF

    Directory of Open Access Journals (Sweden)

    А. А. Симонян

    2016-11-01

    Full Text Available Aim. This prospective randomized study was aimed to assess the progression of atrial fibrillation (AF after ablation procedure and antiarrhythmic drug therapy (AAD in patients with paroxysmal AF by means of implantable cardiac monitors (ICM. Methods. The study enrolled 92 patients with paroxysmal AF, who were eligible either for catheter ablation or AAD. The patients were randomized into two groups: 1 AAD + ICM implantation (group I; n=46, and 2 AF catheter ablation (CA + ICM implantation (group II; n=46, and 2. The primary endpoint was AF progression according to ICM data. The AF progression was defined as AF burden > 30%. A complication rate after ablation procedure and side effects of AAD were determined as the secondary endpoints. The follow up of this study was 24 months. Results. By the end of the follow-up period, AF progression was observed in 27 (58.7% patients in the AAD group and 10 (21.7% patients in the CA group (р=0.0003; HR 0.37, 95% CI [0.17-0.76], р=0.007, Cox regression. 13 (28,3% patients in the AAD group and 2 (4.3% in the CA group (р=0.002 developed persistent AF. The complication rate in the AAD group was 24% (11 patients and 6.5 % (3 patients in the CA group (р=0.02.Conclusion. Radiofrequency ablation of AF leads to a significant decrease in AF progression when compared with antiarrhythmic drug therapy in patients with paroxysmal AF, which was confirmed by implantable cardiac monitors data.Received 12 July 2016. Accepted 22 August 2016.Funding: The study had no sponsorship.Conflict of interest: The authors declare no conflict of interest.

  15. Drikkevands optagelse af cadmium og bly fra armaturer

    DEFF Research Database (Denmark)

    Nielsen, K.

    Notatet omfatter rapporter fra to forsøgsrækker vedr. brugsvands optagelse af bly og cadmium. Den første omhandler brugsvandsarmaturers afgivelse af bly og cadmium til syntetisk brugsvand med en sammensætning svarende til en sur, blød vandtype. Forsøgene omfatter 10 armaturer og armaturdele....... Resultatet af forsøgene var, at et af armaturerne gav vandet et cadmiumindhold, der var væsentlig over den af WHO fastsatte grænse, mens 3 af armaturerne gav blyindhold, der var noget over denne grænse. Den anden rapport behandler afgivelse af cadmium og bly fra forskellige overflader til 3 forskellige...... at eksponere nogle armaturdele, som i Norge i praksis har vist at afgive meget store mængder bly og cadmium....

  16. Vena saphena magna in situ-bypass til ankel og fod. En prospektiv opg|relse af resultaterne af 101 procedurer hos 94 amputationstruede patienter

    DEFF Research Database (Denmark)

    Røder, Ole Christian; Jensen, L P; Schroeder, T V

    1997-01-01

    The results of 101 in situ by-pass operations to the ankle and foot are given. Seventy-five percent of the patients had other arteriosclerotic manifestations and 55% were diabetics. Ninety-nine percent of the operations were limb salvage surgery. The accumulative secondary patency rate was 87% af...

  17. Baggrundsundersøgelser ifm. udarbejdelse af Nationale Annekser til EN1990 og EN1991

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard; Munch-Andersen, Jørgen; Hansen, Svend Ole

    . Endvidere beskrives kombination af laster for STR/GEO og EQU/UPL og kalibrering af partialkoefficienter for laster og materialer. I kapitel 3 behandles udmattelse. I kapitel 4 omtales baggrunden for hvorledes vandret masselast indføres i det nationale anneks til EN1990. Kapitel 5, 6 og 7 beskriver...... baggrunden for nogle af valgene i de nationale annekser til EN1991-1-1 (nyttelast), EN1991-1-3 (snelast) og EN 1991-1-4 (vindlast). kapitel 8 beskriver konsekvensvurderinger dels i form af sammenligninger af regningsmæssige nyttelaster i fleretages huse og dels i et eksempel med eksempler på...

  18. Selvstyring af peroral antikoagulationsbehandling hos patienter med kunstige hjerteklapper

    DEFF Research Database (Denmark)

    Hasenkam, J. Michael; Kimose, H H; Grønnesby, H

    1998-01-01

    of training. No patients experienced major bleeds or thrombo-embolic events. A control group of 20 patients from our department was matched, retrospectively, to the study group. The self-managing patients were within the therapeutic INR range 78% of the study period compared to 54% for the control patients....... All self-managing patients had their median INR-value within the therapeutic range, versus only 14 in the control group. Self-management of oral anticoagulant therapy seems feasible for selected patients. Udgivelsesdato: 1998-Nov-16...

  19. Nyrearteriestenose - diagnostik og behandling

    DEFF Research Database (Denmark)

    Pedersen, Erling Bjerregaard; Andersen, Ulrik Bjørn

    2009-01-01

    Screening for renal artery stenosis (RAS) should be restricted to patients with a high RAS risk. Captopril renography, computed tomography (CT)-angiography, magnetic resonance (MR)-angiography and ultrasound (US) Doppler can be used. Most patients should receive medical treatment. If predictive...

  20. The RecordAF study: design, baseline data, and profile of patients according to chosen treatment strategy for atrial fibrillation

    DEFF Research Database (Denmark)

    Le Heuzey, Jean-Yves; Breithardt, Günter; Camm, John

    2010-01-01

    ,814 patients with AF were registered, and 5,604 were eligible for evaluation. Rhythm- and rate-control strategies were applied to 55% and 45% of patients, respectively, at study inclusion. Rhythm-control patients mainly received class III agents (45%) or beta blockers (51%), except for sotalol, and rate......-control patients mainly received beta blockers (72%), except for sotalol, or cardiac glycosides (34%). Patients receiving a rhythm-control strategy were younger, had a lower resting heart rate, were more frequently symptomatic, and were more likely to have recently diagnosed AF or paroxysmal AF compared...

  1. Rivaroxaban vs. warfarin in Japanese patients with atrial fibrillation – the J-ROCKET AF study –.

    Science.gov (United States)

    Hori, Masatsugu; Matsumoto, Masayasu; Tanahashi, Norio; Momomura, Shin-ichi; Uchiyama, Shinichiro; Goto, Shinya; Izumi, Tohru; Koretsune, Yukihiro; Kajikawa, Mariko; Kato, Masaharu; Ueda, Hitoshi; Iwamoto, Kazuya; Tajiri, Masahiro

    2012-01-01

    The global ROCKET AF study evaluated once-daily rivaroxaban vs. warfarin for stroke and systemic embolism prevention in patients with atrial fibrillation (AF). A separate trial, J-ROCKET AF, compared the safety of a Japan-specific rivaroxaban dose with warfarin administered according to Japanese guidelines in Japanese patients with AF. J-ROCKET AF was a prospective, randomized, double-blind, phase III trial. Patients (n=1,280) with non-valvular AF at increased risk for stroke were randomized to receive 15 mg once-daily rivaroxaban or warfarin dose-adjusted according to Japanese guidelines. The primary objective was to determine non-inferiority of rivaroxaban against warfarin for the principal safety outcome of major and non-major clinically relevant bleeding, in the on-treatment safety population. The primary efficacy endpoint was the composite of stroke and systemic embolism. Non-inferiority of rivaroxaban to warfarin was confirmed; the rate of the principal safety outcome was 18.04% per year in rivaroxaban-treated patients and 16.42% per year in warfarin-treated patients (hazard ratio [HR] 1.11; 95% confidence interval 0.87-1.42; PROCKET AF demonstrated the safety of a Japan-specific rivaroxaban dose and supports bridging the global ROCKET AF results into Japanese clinical practice.

  2. The RecordAF study: design, baseline data, and profile of patients according to chosen treatment strategy for atrial fibrillation

    DEFF Research Database (Denmark)

    Le Heuzey, Jean-Yves; Breithardt, Günter; Camm, John

    2010-01-01

    The REgistry on Cardiac rhythm disORDers assessing the control of Atrial Fibrillation (RecordAF) is the first worldwide, 1-year observational, longitudinal study of the management of paroxysmal/persistent atrial fibrillation (AF) in recently diagnosed patients. The study was conducted at 532 sites...

  3. Behandling med implanterbar defibrillator

    DEFF Research Database (Denmark)

    Roseva-Nielsen, Natasha G; Svendsen, Jesper Hastrup

    2003-01-01

    About 20 years ago the first patient received an implantable cardioverter defibrillator (ICD), and since then the number of implants have increased dramatically. The ICD can terminate ventricular fibrillation and ventricular tachycardia. Studies of secondary prophylaxis show that ICD treatment can...

  4. KOL-patienters oplevelse af dyspnø

    DEFF Research Database (Denmark)

    Christiansen, Sytter; Frederiksen, Kirsten

    2010-01-01

    Dyspnø er en subjektiv oplevelse, der kun vanskeligt lader sig beskrive med objektive målemetoder. Flere små adskilte kvalitative studier beskriver, hvordan patienter med kronisk obstruktiv lungelidelse (KOL) oplever dyspnø. Formål: At syntetisere den eksisterende viden om KOL-patienters oplevels...

  5. Ultralydsskanning af lungerne hos den kritisk syge patient

    DEFF Research Database (Denmark)

    Jepsen, Søren Vad; Christiansen, Aage; Sloth, Erik

    2009-01-01

    Lung sonography is an old technique applied in a new fashion. Applying lung sonography in the examination of an acute patient with pulmonary problems is a novelty in Denmark. Applications, limitations, techniques, equipment and general principles for lung sonography are reviewed. We introduce...... the "typical signs" such as lung sliding and artefacts. The rationale for lung ultrasonography in the treatment of acute patients seems obvious when comparing this technique with conventional diagnostic tools for the diagnosis of pulmonary status. Udgivelsesdato: 2009-Aug-31...

  6. Hjemtagning af dialysebehandling til grønlandske patienter med kronisk nyresvigt

    DEFF Research Database (Denmark)

    Kronborg, Christian; Kjær, Trine; Bech, Mickael

    en periode på 10 år forventes at medføre ekstraomkostninger på ca. 13,9 millioner kroner sammenlignet med at lade patienterne behandle som nu på Rigshospitalet i København. Det vil altså sige en gennemsnitlig ekstraomkostning på ca. 4 millioner kroner om året. Estimatet er dog påvirkeligt at flere...

  7. Årsager, udredning og behandling af abortus habitualis

    DEFF Research Database (Denmark)

    Larsen, Elisabeth Clare; Christiansen, Ole Bjarne

    2012-01-01

    facing RM should be offered tender loving care; i.e. repeated measurements of hCG and ultrasound scans. Further treatments are directed against the underlying cause: surgery, hormone supplementation, anticoagulation and immunomodulation. However, the effect of these treatments needs further documentation....

  8. Antibiotika som primær behandling af appendicitis

    DEFF Research Database (Denmark)

    Hupfeld, Line; Pommergaard, Hans-Christian; Burcharth, Jakob

    2014-01-01

    Acute appendicitis has traditionally been treated surgically. Conservative approach with antibiotic treatment has been suggested as an alternative to the surgical procedure. The available studies on surgery versus antibiotics may indicate the safe use of conservative treatment for uncomplicated...... appendicitis, but the available studies are typically of low quality. Thus, further studies are needed to clarify the role of conservative treatment, and in the meantime appendectomy remains the standard treatment for acute appendicitis....

  9. Status og perspektiver for behandling af de kroniske myeloproliferative neoplasier

    DEFF Research Database (Denmark)

    Ocias, Lukas Frans; Holmström, Morten Orebo; Riley, Caroline Hasselbalch

    2015-01-01

    of these malignancies has focused on lowering their inherent thromboembolic risk but with the discovery of the JAK2-V617F mutation and most recently the calreticulin mutations new therapeutic options such as interferon-alpha, JAK2-inhibitors and statins are being contemplated. This article reviews these new treatment...

  10. Flibanserin som farmakologisk behandling af nedsat lyst hos kvinder

    DEFF Research Database (Denmark)

    Eldon, Anne Sofie; Giraldi, Annamaria

    2017-01-01

    Flibanserin was approved by the Food and Drug Administration in the USA in August 2015 as the first drug for the treatment of American women with the dysfunction hypoactive sexual desire disorder (HSDD) and is a 5-HT1A agonist and 5-HT2A antagonist. The neurophysiological effects of flibanserin...... on these receptors are consistent with the clinical effects, i.e. significantly increasing sexual desire and frequency of satisfying sexual experiences. As such, shifting the balance between inhibitory and excitatory neurotransmitters of importance to sexual desire, flibanserin pharmacologically broaches a possible...... new approach to the treatment of HSDD....

  11. Sammenlimning af begge øjne skal ikke behandles konservativt

    DEFF Research Database (Denmark)

    Øgard, Carsten; Kjaerbo, Hadi; Sørensen, Torben Lykke

    2010-01-01

    We describe a case of a 4-year-old boy who accidentally had both eyes glued together. The eyelashes were cut and the boy's eyelids were separated in general anaesthesia. When both eyes are glued together, we do not recommend expectancy, especially not in paediatric cases. For psychological reason...

  12. Fotodynamisk behandling af kolangiokarcinom hos 80-årig

    DEFF Research Database (Denmark)

    Ulstrup, Thomas; Pedersen, Finn Møller

    2013-01-01

    70% of cholangiocarcinomas (CC) are perihilar lesions. At the time of diagnosis few are candidates for complete resection, and the standard palliative therapy has been biliary stenting. Studies have shown that photodynamic therapy (PDT) improves survival time. In this case report we describe an 80...

  13. Linezolid som behandling af infektiøs endokarditis

    DEFF Research Database (Denmark)

    Lauridsen, Trine Kiilerich; Arpi, Magnus; Bruun, Niels Eske

    2010-01-01

    In Denmark enterococci causes 15 to 20% of all endocarditis (IE) cases. The development of multi-resistant bacterial strains has increased the need for new antibiotics. Linezolid is an alternative to conventional treatment of infections with gram positive cocci. In this case report linezolid...

  14. Osteoporosens betydning for behandling af frakturer og ortopaediske muligheder

    DEFF Research Database (Denmark)

    Lauritzen, J B

    2001-01-01

    be delayed. The structural grafts may be biologically inert or osteoconductive, but also osteoinductive, and various osteoinductive growth factors and hormones could be a supplement to treatment. Several types of osteosyntheses have improved the clinical outcome, among them: sliding hip screw, neck screws...

  15. Evidensbaseret behandling af psykisk syge hjemløse

    DEFF Research Database (Denmark)

    Larsen, Maja; Nordentoft, Merete

    2010-01-01

    A systematic review of the literature shows that it is possible to reduce homelessness among mentally ill homeless persons, partly by offering access to housing and partly by providing intensive care through Assertive Community Treatment. Assertive Community Treatment can, to some extent, decrease...

  16. Udredning og behandling af osteoporose ved cancer mammae uden knoglemetastaser

    DEFF Research Database (Denmark)

    Eiken, Pia Agnete; Hansen, Mogens; Kristensen, Bent

    2011-01-01

    The prevention of cancer-treatment-induced bone loss due to chemotherapy and long-term adjuvant breast cancer therapy has a high priority. We present an algorithm for the prevention and treatment of osteoporosis during treatment of nonmetastatic breast cancer.......The prevention of cancer-treatment-induced bone loss due to chemotherapy and long-term adjuvant breast cancer therapy has a high priority. We present an algorithm for the prevention and treatment of osteoporosis during treatment of nonmetastatic breast cancer....

  17. Behandling af pilonidalcyster med neodynium-yttriumaluminiumgranat-laser

    DEFF Research Database (Denmark)

    Lindholt, Christine S; Lindholt, Jes S; Lindholt, Jan

    2008-01-01

    A 23 year-old woman with a nonsupporative pilonidal cyst was successfully treated causally with Nd-YAG laser, and without any recidivate after 9 months follow-up. The mechanism is presumed to be that YAG-laser has a wave-length of 1064 nm. Consequently, the wave penetration through the skin is de...... is deeper than most other lasers before the energy is absorbed in melanin and oxyhaemoglobin, so the contents of the cyst can be reached and destroyed. The treatment could be a very attractive alternative to open surgery. Udgivelsesdato: 2008-Jun-23...

  18. Behandling af pilonidalcyster med neodynium-yttriumaluminiumgranat-laser

    DEFF Research Database (Denmark)

    Lindholt, Christine S; Lindholt, Jes Sanddal; Lindholt, Jan

    2008-01-01

    A 23 year-old woman with a nonsupporative pilonidal cyst was successfully treated causally with Nd-YAG laser, and without any recidivate after 9 months follow-up. The mechanism is presumed to be that YAG-laser has a wave-length of 1064 nm. Consequently, the wave penetration through the skin is de...... is deeper than most other lasers before the energy is absorbed in melanin and oxyhaemoglobin, so the contents of the cyst can be reached and destroyed. The treatment could be a very attractive alternative to open surgery....

  19. Medicinsk behandling af osteoporose hos mænd

    DEFF Research Database (Denmark)

    Eiken, Pia A; Vestergaard, Peter

    2015-01-01

    One in five men over the age of 50 years will suffer an osteoporotic fracture during their lifetime, and men who sustain fractures have an increased mortality risk compared to women. Three bisphosphonates (alendronate, risedronate and zolendronic acid), denosumab, strontium ranelate and teriparat...... and teriparatide are currently approved in Denmark for the treatment of osteoporosis in men. This review summarizes the available therapeutic options....

  20. Udredning og behandling af osteoporose ved cancer mammae uden knoglemetastaser

    DEFF Research Database (Denmark)

    Eiken, Pia Agnete; Hansen, Mogens; Kristensen, Bent

    2011-01-01

    The prevention of cancer-treatment-induced bone loss due to chemotherapy and long-term adjuvant breast cancer therapy has a high priority. We present an algorithm for the prevention and treatment of osteoporosis during treatment of nonmetastatic breast cancer....

  1. Medicinsk behandling af osteoporose hos mænd

    DEFF Research Database (Denmark)

    Eiken, Pia A; Vestergaard, Peter

    2016-01-01

    One in five men over the age of 50 years will suffer an osteoporotic fracture during their lifetime, and men who sustain fractures have an increased mortality risk compared to women. Three bisphosphonates (alendronate, risedronate and zolendronic acid), denosumab, strontium ranelate and teriparat...

  2. Medicinsk behandling af osteoporose hos mænd

    DEFF Research Database (Denmark)

    Eiken, Pia A; Vestergaard, Peter

    2015-01-01

    One in five men over the age of 50 years will suffer an osteoporotic fracture during their lifetime, and men who sustain fractures have an increased mortality risk compared to women. Three bisphosphonates (alendronate, risedronate and zolendronic acid), denosumab, strontium ranelate and teriparat...

  3. Medicinsk behandling af vandladningsproblemer hos mænd

    DEFF Research Database (Denmark)

    Andersen, Jens Thorup; Nordling, Jørgen; Walter, Steen

    2007-01-01

    Lower Urinary Tract Symptoms (LUTS) e.g. in prostatic infravesical obstruction and symptoms of overactive bladder (OAB) in men can be treated effectively with drugs. The current evidence for use of alpha-adrenergic blocking agents, 5-alpha-reductase inhibitors, combination therapy and antimuscari...... by the administration of a loop-diuretic in the late afternoon. Udgivelsesdato: 2007-May-14...

  4. Endovenøs termisk behandling af varicer i underekstremiteterne

    DEFF Research Database (Denmark)

    Bækgaard, Niels; Schroeder, Torben V

    2011-01-01

    Using a systematic review process, we identified 15 randomised controlled trials comparing either of the two endovenous thermal techniques, radiofrequency or laser ablation, with conventional open surgery for great saphenous varicose veins. The majority of trials were small and had short-term fol...

  5. Laktatacidose ved behandling af type 2-diabetes med metformin

    DEFF Research Database (Denmark)

    Holst, Helle; Eldrup, Ebbe; Guldstad, Nana Harriet

    2012-01-01

    Metformin (MET) is the first-line agent in treatment of type 2 diabetes. However, MET has been associated with lactic acidosis (MALA), a potential but rare complication which has influenced treatment strategies in decades. Recently, guidelines have been changed in regards of age and heart failure...... and the contradiction of chronic renal impairment has been debated. This article identifies potential risk groups and situations that would benefit from a temporary interruption in the MET treatment....

  6. Diagnose og behandling af cerebral venøs sinustrombose

    DEFF Research Database (Denmark)

    Birkeland, Peter; Stilling, Margit Vejen; Høgedal, Lisbeth

    2015-01-01

    Thrombosis of the cerebral sinuses most often affects younger adults. Headache is a common complaint and can be accom­panied by vomiting and papilloedema. The diagnosis rests on magnetic resonance imaging and the treatment consists of heparin or low-molecular weight heparin followed by vitamin K...

  7. Kombineret kirurgisk og onkologisk behandling af kolorektale levermetastaser

    DEFF Research Database (Denmark)

    Bergenfeldt, M.; Jensen, B.V.

    2008-01-01

    Isolated colorectal liver metastases should be referred for multispecialist management at a liver centre. Long-time survival is possible after resection and adjuvant therapy. If unresectable, newer chemotherapy with oxaliplatin, irinitecan, bevacizumab and cetuximab may result in a median survival...

  8. Kirurgisk behandling af fedme hos børn

    DEFF Research Database (Denmark)

    Hansen, Ann Berit; Gögenur, Ismail; Støckel, Mikael

    2014-01-01

    Morbid obesity in teenagers has become an increasing problem. Conventional diet has not yet shown effective long-term weight loss. Alternatively, bariatric surgery on adolescents has resulted in substantial weight loss, recovery from diabetes, improvement of cardiovascular risk factors...... and improvement in psychosocial status. Still, surgery performed on adolescents provides ethical challenges such as the unknown long-term prognosis after surgery. Despite these challenges, in cases of severe intractable obesity or development of life-threatening complications due to obesity, surgery should...

  9. Årsager, udredning og behandling af abortus habitualis

    DEFF Research Database (Denmark)

    Larsen, Elisabeth Clare; Christiansen, Ole Bjarne

    2012-01-01

    Recurrent miscarriage (RM) is defined as three or more consecutive early pregnancy losses and affects 1% of couples. RM is probably a multifactorial disease and evaluation includes parental karyotyping, testing for uterine anomalies, thyroid dysfunction, thrombophilia and immune factors. Couples...

  10. Evidensbaseret behandling af psykisk syge hjemløse

    DEFF Research Database (Denmark)

    Larsen, Maja; Nordentoft, Merete

    2010-01-01

    A systematic review of the literature shows that it is possible to reduce homelessness among mentally ill homeless persons, partly by offering access to housing and partly by providing intensive care through Assertive Community Treatment. Assertive Community Treatment can, to some extent, decrease...... psychiatric symptoms and increase quality of life. It is evident that by offering housing, homelessness may be reduced, but the comparison of independent housing and group living did not reveal big differences....

  11. Klinik, diagnostik og behandling af Lyme-borreliose

    DEFF Research Database (Denmark)

    Ocias, Lukas Frans; Jensen, Bo Bødker; Knudtzen, Fredrikke Christie

    2017-01-01

    Lyme borreliosis is an infection caused by the Borrelia burgdorferi sensu lato complex and transmitted by Ixodes ricinus ticks in Denmark. It can manifest itself in several different forms of which erythema migrans is the most common and is diagnosed by clinical assessment of the characteristic...

  12. Effektiv behandling af hyperkalcaemi ved neonatal subkutan fedtnekrose

    DEFF Research Database (Denmark)

    Bergstein, Katrine Ryttov; Jacobsen, Ronni Bengtson; Jacobsen, Bengt Brock

    2010-01-01

    This is a description of two cases of subcutaneous fat necrosis due to asphyxia in two newborns, and associated hypercalcaemia. Treatment with intravenous pamidronate 0.5 mg/kg for three days was very successful and well-tolerated. In conclusion, the treatment of hypercalcaemia was effective...

  13. Dasatinib. En ny tyrosinkinaseinhibitor til behandling af kronisk myeloid leukaemi

    DEFF Research Database (Denmark)

    Bjerrum, Ole Weis; Dufva, Inge Høgh; Stentoft, Jesper

    2008-01-01

    Chronic myeloid leukaemia is characterized by an abnormal tyrosin kinase in the cytoplasm of the clonal cells. The enzyme is derived from a fusion gene on the Philadelphia-chromosome, evolved by a translocation between chromosomes 9 and 22. Understanding the biology of the tyrosin kinase led to t...... to targeted therapy, inhibiting the ATP-binding site by a small molecule--imatinib (Glivec). A novel 2nd generation tyrosin kinase inhibitor--dasatinib (Sprycel)--is now available in cases of insufficient response or intolerance to imatinib. Udgivelsesdato: 2008-Jan-28...

  14. Salmonella typhi--tid til aendring af den empiriske behandling

    DEFF Research Database (Denmark)

    Gade, Christina; Engberg, Jørgen; Weis, Nina

    2008-01-01

    out of seven cases. We recommend that empiric treatment of suspected cases of typhoid fever includes a third generation cephalosporin such as ceftriaxon. Furthermore, the present report stresses the importance of typhoid vaccination of travellers to areas where typhoid is endemic. Udgivelsesdato: 2008...

  15. Kirurgisk behandling af anale fistler ved Crohns sygdom

    DEFF Research Database (Denmark)

    Heyckendorff-Diebold, Tina; Maeda, Yasuko; Buntzen, Steen

    2012-01-01

    The treatment of transsphincteric anal fistulas in Crohn's disease is a balance between the elimination of the sepsis and the functional outcome. Loose setons can be used as a preoperative drainage or chronic treatment. Fibrin glue and the anal fistula plug are methods with excellent functional...

  16. Narrativ og evidensbaseret behandling af komplekst traumatiserede mennesker

    DEFF Research Database (Denmark)

    Riber, Karin; Lindvig, Ditte

    2011-01-01

    Many survivors of potentially traumatizing events develop serious psychological problems. This article aims to critically examine two fundamentally different treatment paradigms. The article presents and discusses Michael White's narrative therapy, Metin Basoglu's modified behaviour therapy and F...

  17. Telemedicinsk praehospital diagnostik og visitation af en patient med aortadissektion

    DEFF Research Database (Denmark)

    Terkelsen, Astrid Juhl; Lambrechtsen, Jess; Kaltoft, Anne

    2008-01-01

    Thoracic aortic dissection is a life-threatening emergency that must be met and surmounted immediately to increase survival. In this case, telemedicine involving ECG and GSM-based communication between the patient in the ambulance and the centre doctor was used to obtain remote pre-hospital suspi...

  18. Telemedicinsk praehospital diagnostik og visitation af en patient med aortadissektion

    DEFF Research Database (Denmark)

    Terkelsen, Astrid Juhl; Lambrechtsen, Jess; Kaltoft, Anne

    2008-01-01

    Thoracic aortic dissection is a life-threatening emergency that must be met and surmounted immediately to increase survival. In this case, telemedicine involving ECG and GSM-based communication between the patient in the ambulance and the centre doctor was used to obtain remote pre-hospital...

  19. Udvikling af sklerodermisk krise hos patient med uerkendt sklerodermi

    DEFF Research Database (Denmark)

    Madsen, Kristine Lindhard; Hansen, Alastair; Halberg, Poul

    2014-01-01

    Less than 10% of the patients with systemic scleroderma develop renal crisis, i.e. acute renal failure and severe hypertension in most cases. Kidney biopsy shows hypertensive arteriolar changes. This complication was lethal until treatment with captopril was introduced in 1976. Since that time...

  20. Hurtig identifikation af patienter med neutropeni og feber bedrer prognosen

    DEFF Research Database (Denmark)

    Johansson, Sofia; Jensen, Lars Henrik

    2015-01-01

    The purpose of this article is to describe the management of febrile neutropenia in the medical emergency room. Symptoms and signs of inflammation in patients receiving chemotherapy may be blunted or absent and fever may be the only sign of severe infection. Early initiation of empirical antibiot......The purpose of this article is to describe the management of febrile neutropenia in the medical emergency room. Symptoms and signs of inflammation in patients receiving chemotherapy may be blunted or absent and fever may be the only sign of severe infection. Early initiation of empirical...... antibiotics is essential for the outcome. A beta-lactam antibiotic is the treatment of choice and the regimen should be re-evaluated frequently in absence of clinical improvement. The treating oncologist should always be involved for advice and for assuring adjustments in future chemotherapy....

  1. ROCKET AF adds more concerns about Digoxin safety in patients with atrial fibrillation

    Science.gov (United States)

    ElMaghawry, Mohamed

    2015-01-01

    In a recent article in the Journal, we have reviewed the adverse cardiovascular outcomes observed with digoxin use in the PALLAS study.1 The PALLAS study was designed to determine if dronedarone would reduce major vascular events in patients with permanent atrial fibrillation (AF).2 However the study was stopped early because of safety reasons, as a significant number of patients on the dronedarone arm reached the co-primary end point composite of stroke, myocardial infarction, systemic embolism, or cardiovascular death. Data sub-analyses suggested that digoxin-dronedarone interaction was responsible for the higher arrhythmic death rate observed in the trial. These observations are consistent with several other studies that demonstrate the potential hazard of the use of digoxin in heart failure and/or atrial fibrillation. A more recent article published in the Lancet studied the use and outcomes of digoxin in the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism in Atrial Fibrillation (ROCKET AF) trial.3 The investigators concluded that digoxin treatment was associated with a significant increase in all-cause mortality, vascular death, and sudden death in patients with AF. PMID:26779514

  2. Medicinsk teknologivurdering af akupunktur til gravide

    DEFF Research Database (Denmark)

    Feenstra, Maria Monberg; Johansen, Marianne; Sørensen, Lisbeth Falborg

    -, organisatorisk- og økonomisk perspektiv. Metode: Der blev udarbejdet en medicinsk teknologivurdering (MTV). En alsidig og systematisk litteraturgennemgang af akupunkturbehandling til gravide med emesis/hyperemesis gravidarum, bækkenrelaterede smerter eller depression/angst blev udført. Den udvalgte litteratur...... behandlingen udføres korrekt af TCM-uddannet sundhedspersonale. Undersøgelser har vist høj patienttilfredshed blandt gravide ved akupunkturbehandling. Økonomiske beregninger dokumenterer, at akupunktur er et billigt behandlingstilbud. Konsekvenser for praksis: Det anbefales, at tilbyde gravide med emesis/hyperemesis...... gravidarum akupunkturbehandling. Udvalgt sundhedspersonale skal uddannes til at give behandlingen, og der bør tilstræbes kontinuitet i behandlingsforløbet. Yderligere studier, der undersøger evidensen for behandling af bækkenrelaterede smerter og depression/angst med akupunktur, anbefales....

  3. Kliniske retningslinjer for træning af aerob kapacitet og muskelstyrke til patienter med reumatoid artrit

    DEFF Research Database (Denmark)

    Larsen, Birgit Tine; Læssøe, Uffe; Kjær, Thomas

    Baggrund: Patienter med reumatoid artrit har en forhøjet risiko for udviklingen af cardio-vaskulære lidelser (CVD) ogtidlig død. Inflammation, smerter og generel træthed resulterer i nedsat muskelstyrke og lavt fysiskfunktions- og aktivitetsniveau hos mange af disse patienter, hvilket yderligere...... forstærker denne risiko. Formål: Gennem effektiv og sikker træning at øge RA patienters aerob kapacitet og muskel styrke for dermed atlette patienternes daglige aktiviteter. Patienter: Voksne patienter (> 18 år) med diagnosen reumatoid artrit ifølge ARA eller ACR/EULAR kriterierne,funktionsklasserne I, II og...... reumatoid artrit. Kortvarig landbaseret højintensitets træning af aerob kapacitet og muskelstyrke bør overvejes itræningen af patienter med reumatoid artrit. Længerevarende landbaseret højintensitets træning af aerob kapacitet og muskelstyrke bør overvejes itræningen af patienter med reumatoid artrit...

  4. Rivaroxaban for stroke prevention in East Asian patients from the ROCKET AF trial.

    Science.gov (United States)

    Wong, Ka Sing Lawrence; Hu, Dai Yi; Oomman, Abraham; Tan, Ru-San; Patel, Manesh R; Singer, Daniel E; Breithardt, Günter; Mahaffey, Kenneth W; Becker, Richard C; Califf, Robert; Fox, Keith A A; Berkowitz, Scott D; Hacke, Werner; Hankey, Graeme J

    2014-06-01

    In Rivaroxaban Once Daily Oral Direct Factor Xa Inhibitor Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) trial, rivaroxaban was noninferior to dose-adjusted warfarin in preventing stroke or systemic embolism among patients with nonvalvular atrial fibrillation at moderate to high stroke risk. Because of differences in patient demographics, epidemiology, and stroke risk management in East Asia, outcomes and relative effects of rivaroxaban versus warfarin were assessed to determine consistency among East Asians versus other ROCKET AF participants. Baseline demographics and interaction of treatment effects of rivaroxaban and warfarin among patients within East Asia and outside were assessed. A total of 932 (6.5%) ROCKET AF participants resided in East Asia. At baseline, East Asians had lower weight, creatinine clearance, and prior vitamin K antagonist use; higher prevalence of prior stroke; and less congestive heart failure and prior myocardial infarction than other participants. Despite higher absolute event rates for efficacy and safety outcomes in East Asians, the relative efficacy of rivaroxaban (20 mg once daily; 15 mg once daily for creatinine clearance of 30-49 mL/min) versus warfarin with respect to the primary efficacy end point (stroke/systemic embolism) was consistent among East Asians and non-East Asians (interaction P=0.666). Relative event rates for the major or nonmajor clinically relevant bleeding in patients treated with rivaroxaban and warfarin were consistent among East Asians and non-East Asians (interaction P=0.867). Observed relative efficacy and safety of rivaroxaban versus warfarin were similar among patients within and outside East Asia. Rivaroxaban, 20 mg once daily, is an alternative to warfarin for stroke prevention in East Asians with nonvalvular atrial fibrillation. © 2014 American Heart Association, Inc.

  5. Definitionen af CFC-indkomst og adgangen til dispensation

    DEFF Research Database (Denmark)

    Schmidt, Peter Koerver

    2014-01-01

    I artiklen kommenteres to nyere afgørelser omhandlende CFC-reglerne for selskaber. Først behandles Skatterådets afgørelse i SKM2013.649.SR, der bl.a. angik, hvorvidt et udenlandsk datterselskabs indkomst udgjorde CFC-indkomst i form af vederlag for anvendelse af immaterielle aktiver. Derpå omtale...... kendelsen SKM2014.280.LSR, hvori Landsskatteretten - modsat Skatterådet - kom frem til, at betingelserne for dispensation fra CFC-reglerne var opfyldt....

  6. Characteristics and outcomes of atrial fibrillation patients with or without specific symptoms: results from the PREFER in AF registry.

    Science.gov (United States)

    Bakhai, Ameet; Darius, Harald; De Caterina, Raffaele; Smart, Angela; Le Heuzey, Jean-Yves; Schilling, Richard John; Zamorano, José Luis; Shah, Mit; Bramlage, Peter; Kirchhof, Paulus

    2016-10-01

    Atrial fibrillation (AF) is a common condition that is a major cause of stroke. A significant proportion of patients with AF are not classically symptomatic at diagnosis or soon after diagnosis. There is little information comparing their characteristics, treatment, and outcomes of patients with symptoms, which predominate in clinical trials to those without. We analysed data from the Prevention of Thromboembolic Events-European Registry in Atrial Fibrillation. This was a prospective, real-world registry with a 12-month follow-up that included AF patients aged 18 years and over. Patients were divided into those with and without AF symptoms using the European Heart Rhythm Association (EHRA) score (Category I vs. Categories II-IV). Of the 6196 patients (mean age 72 years) with EHRA scores available, 501 (8.1%) were asymptomatic. A lower proportion of asymptomatic patients was female (22.8 vs. 41.2%), with less noted to have heart failure and coronary artery disease (P attack; P = 0.840). Patients with higher CHA2DS2-VASc and HAS-BLED scores experienced more events, independent of symptoms. Antithrombotic therapy was comparable for both groups at baseline and at follow-up. The similar clinical characteristics and frequency of adverse events between asymptomatic and symptomatic AF patients revives the question of whether screening programmes to detect people with asymptomatic AF are worthwhile, particularly in those aged 65 and over potentially likely to have clinical and economic benefits from anticoagulants. This evidence may be informative if clinicians may not be comfortable participating in future clinical trials, leaving asymptomatic patients with AF and high stroke risk without anticoagulation.

  7. Patients' time in therapeutic range on warfarin among US patients with atrial fibrillation: Results from ORBIT-AF registry.

    Science.gov (United States)

    Pokorney, Sean D; Simon, DaJuanicia N; Thomas, Laine; Fonarow, Gregg C; Kowey, Peter R; Chang, Paul; Singer, Daniel E; Ansell, Jack; Blanco, Rosalia G; Gersh, Bernard; Mahaffey, Kenneth W; Hylek, Elaine M; Go, Alan S; Piccini, Jonathan P; Peterson, Eric D

    2015-07-01

    Time in therapeutic range (TTR) of international normalized ratio (INR) of 2.0 to 3.0 is important for the safety and effectiveness of warfarin anticoagulation. There are few data on TTR among patients with atrial fibrillation (AF) in community-based clinical practice. Using the US Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF), we examined TTR (using a modified Rosendaal method) among 5,210 patients with AF on warfarin and treated at 155 sites. Patients were grouped into quartiles based on TTR data. Multivariable logistic regression modeling with generalized estimating equations was used to determine patient and provider factors associated with the lowest (worst) TTR. Overall, 59% of the measured INR values were between 2.0 and 3.0, with an overall mean and median TTR of 65% ± 20% and 68% (interquartile range [IQR] 53%-79%). The median times below and above the therapeutic range were 17% (IQR 8%-29%) and 10% (IQR 3%-19%), respectively. Patients with renal dysfunction, advanced heart failure, frailty, prior valve surgery, and higher risk for bleeding (ATRIA score) or stroke (CHA2DS2-VASc score) had significantly lower TTR (P range. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

  8. Higher risk of death and stroke in patients with persistent vs. paroxysmal atrial fibrillation: results from the ROCKET-AF Trial

    Science.gov (United States)

    Steinberg, Benjamin A.; Hellkamp, Anne S.; Lokhnygina, Yuliya; Patel, Manesh R.; Breithardt, Günter; Hankey, Graeme J.; Becker, Richard C.; Singer, Daniel E.; Halperin, Jonathan L.; Hacke, Werner; Nessel, Christopher C.; Berkowitz, Scott D.; Mahaffey, Kenneth W.; Fox, Keith A.A.; Califf, Robert M.; Piccini, Jonathan P.

    2015-01-01

    Aim Anticoagulation prophylaxis for stroke is recommended for at-risk patients with either persistent or paroxysmal atrial fibrillation (AF). We compared outcomes in patients with persistent vs. paroxysmal AF receiving oral anticoagulation. Methods and results Patients randomized in the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET-AF) trial (n = 14 264) were grouped by baseline AF category: paroxysmal or persistent. Multivariable adjustment was performed to compare thrombo-embolic events, bleeding, and death between groups, in high-risk subgroups, and across treatment assignment (rivaroxaban or warfarin). Of 14 062 patients, 11 548 (82%) had persistent AF and 2514 (18%) had paroxysmal AF. Patients with persistent AF were marginally older (73 vs. 72, P = 0.03), less likely female (39 vs. 45%, P < 0.0001), and more likely to have previously used vitamin K antagonists (64 vs. 56%, P < 0.0001) compared with patients with paroxysmal AF. In patients randomized to warfarin, time in therapeutic range was similar (58 vs. 57%, P = 0.94). Patients with persistent AF had higher adjusted rates of stroke or systemic embolism (2.18 vs. 1.73 events per 100-patient-years, P = 0.048) and all-cause mortality (4.78 vs. 3.52, P = 0.006). Rates of major bleeding were similar (3.55 vs. 3.31, P = 0.77). Rates of stroke or systemic embolism in both types of AF did not differ by treatment assignment (rivaroxaban vs. warfarin, Pinteraction = 0.6). Conclusion In patients with AF at moderate-to-high risk of stroke receiving anticoagulation, those with persistent AF have a higher risk of thrombo-embolic events and worse survival compared with paroxysmal AF. PMID:25209598

  9. Higher risk of death and stroke in patients with persistent vs. paroxysmal atrial fibrillation: results from the ROCKET-AF Trial.

    Science.gov (United States)

    Steinberg, Benjamin A; Hellkamp, Anne S; Lokhnygina, Yuliya; Patel, Manesh R; Breithardt, Günter; Hankey, Graeme J; Becker, Richard C; Singer, Daniel E; Halperin, Jonathan L; Hacke, Werner; Nessel, Christopher C; Berkowitz, Scott D; Mahaffey, Kenneth W; Fox, Keith A A; Califf, Robert M; Piccini, Jonathan P

    2015-02-01

    Anticoagulation prophylaxis for stroke is recommended for at-risk patients with either persistent or paroxysmal atrial fibrillation (AF). We compared outcomes in patients with persistent vs. paroxysmal AF receiving oral anticoagulation. Patients randomized in the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET-AF) trial (n = 14 264) were grouped by baseline AF category: paroxysmal or persistent. Multivariable adjustment was performed to compare thrombo-embolic events, bleeding, and death between groups, in high-risk subgroups, and across treatment assignment (rivaroxaban or warfarin). Of 14 062 patients, 11 548 (82%) had persistent AF and 2514 (18%) had paroxysmal AF. Patients with persistent AF were marginally older (73 vs. 72, P = 0.03), less likely female (39 vs. 45%, P < 0.0001), and more likely to have previously used vitamin K antagonists (64 vs. 56%, P < 0.0001) compared with patients with paroxysmal AF. In patients randomized to warfarin, time in therapeutic range was similar (58 vs. 57%, P = 0.94). Patients with persistent AF had higher adjusted rates of stroke or systemic embolism (2.18 vs. 1.73 events per 100-patient-years, P = 0.048) and all-cause mortality (4.78 vs. 3.52, P = 0.006). Rates of major bleeding were similar (3.55 vs. 3.31, P = 0.77). Rates of stroke or systemic embolism in both types of AF did not differ by treatment assignment (rivaroxaban vs. warfarin, Pinteraction = 0.6). In patients with AF at moderate-to-high risk of stroke receiving anticoagulation, those with persistent AF have a higher risk of thrombo-embolic events and worse survival compared with paroxysmal AF. © The Author 2014. Published by Oxford University Press on behalf of the European Society of Cardiology.

  10. The RecordAF study: design, baseline data, and profile of patients according to chosen treatment strategy for atrial fibrillation

    DEFF Research Database (Denmark)

    Le Heuzey, Jean-Yves; Breithardt, Günter; Camm, John

    2010-01-01

    in 21 countries across Europe, America, and Asia; recruitment was completed in April 2008. The primary objectives were to prospectively assess the therapeutic success and clinical outcomes in rhythm- and rate-control strategies. The study design and patient baseline data are reported. A total of 5......The REgistry on Cardiac rhythm disORDers assessing the control of Atrial Fibrillation (RecordAF) is the first worldwide, 1-year observational, longitudinal study of the management of paroxysmal/persistent atrial fibrillation (AF) in recently diagnosed patients. The study was conducted at 532 sites......,814 patients with AF were registered, and 5,604 were eligible for evaluation. Rhythm- and rate-control strategies were applied to 55% and 45% of patients, respectively, at study inclusion. Rhythm-control patients mainly received class III agents (45%) or beta blockers (51%), except for sotalol, and rate...

  11. Implementering af ny standard for forebyggelse af delir i forhold til ældre svagelige patienter > 65 år med hoftefraktur

    DEFF Research Database (Denmark)

    Bagger, Bettan; Rehder, Bente; Pedersen, Niels

    2013-01-01

    Baggrund: Pro-hip er et inter-regionalt projekt www.prohip.eu der blandt andet har til formål at evidensbasere den rehabiliterende sygepleje til hoftepatienten i forhold til indsatsområderne; ernæring, urinretention/UVI, delir og tryksår. Delirium er et hyppigt forekommende problem blandt patienter...... standard. Intentionen er således at udvikle en evidensbaseret standard eller instruks, der har til formål at opspore tidlige symptomer på konfusion og dermed forebygge udviklingen af deliriøs tilstand hos patienten med hoftefraktur. Metode: Der er udarbejdet et systematisk review med henblik på...

  12. U.2010 B.1; Fagforeningers kontrol af virksomheders løn- og arbejdsvilkår

    DEFF Research Database (Denmark)

    Lind, Martin Gräs

    2010-01-01

    Artiklen behandler spørgsmålet, om og i hvilket omfang fagforeninger har ret til at kontrollere især overenskomstforpligtede arbejdsgivere. Det stigende antal udenlandske arbejdstagere på det danske arbejdsmarked har medført øget fokus på og behov for kontrolførelse af overenskomstens bestemmelse......, bl.a. for at sikre mod illegal beskæftigelse, omgåelse af overenskomsterne og social dumping....

  13. Outcomes after cardioversion and atrial fibrillation ablation in patients treated with rivaroxaban and warfarin in the ROCKET AF trial.

    Science.gov (United States)

    Piccini, Jonathan P; Stevens, Susanna R; Lokhnygina, Yuliya; Patel, Manesh R; Halperin, Jonathan L; Singer, Daniel E; Hankey, Graeme J; Hacke, Werner; Becker, Richard C; Nessel, Christopher C; Mahaffey, Kenneth W; Fox, Keith A A; Califf, Robert M; Breithardt, Günter

    2013-05-14

    This study sought to investigate the outcomes following cardioversion or catheter ablation in patients with atrial fibrillation (AF) treated with warfarin or rivaroxaban. There are limited data on outcomes following cardioversion or catheter ablation in AF patients treated with factor Xa inhibitors. We compared the incidence of electrical cardioversion (ECV), pharmacologic cardioversion (PCV), or AF ablation and subsequent outcomes in patients in a post hoc analysis of the ROCKET AF (Efficacy and Safety Study of Rivaroxaban With Warfarin for the Prevention of Stroke and Non-Central Nervous System Systemic Embolism in Patients With Non-Valvular Atrial Fibrillation) trial. Over a median follow-up of 2.1 years, 143 patients underwent ECV, 142 underwent PCV, and 79 underwent catheter ablation. The overall incidence of ECV, PCV, or AF ablation was 1.45 per 100 patient-years (n = 321; 1.44 [n = 161] in the warfarin arm, 1.46 [n = 160] in the rivaroxaban arm). The crude rates of stroke and death increased in the first 30 days after cardioversion or ablation. After adjustment for baseline differences, the long-term incidence of stroke or systemic embolism (hazard ratio [HR]: 1.38; 95% confidence interval [CI]: 0.61 to 3.11), cardiovascular death (HR: 1.57; 95% CI: 0.69 to 3.55), and death from all causes (HR: 1.75; 95% CI: 0.90 to 3.42) were not different before and after cardioversion or AF ablation. Hospitalization increased after cardioversion or AF ablation (HR: 2.01; 95% CI: 1.51 to 2.68), but there was no evidence of a differential effect by randomized treatment (p value for interaction = 0.58). The incidence of stroke or systemic embolism (1.88% vs. 1.86%) and death (1.88% vs. 3.73%) were similar in the rivaroxaban-treated and warfarin-treated groups. Despite an increase in hospitalization, there were no differences in long-term stroke rates or survival following cardioversion or AF ablation. Outcomes were similar in patients treated with rivaroxaban or warfarin

  14. Elektronisk journalplatform i den fysioterapeutiske praksis til kvalitetssikring og dokumentation af praksis

    DEFF Research Database (Denmark)

    Larsen, Birgit Tine; Bie Larsen, Jesper; Harboe, Michael

    deltog firmaet DIGIfys i undervisningen på modul 3, og 11, hvor de studerende blev inddraget i projektet gennem anvendelse af den elektroniske platform i tilrettelæggelsen af træningsprogrammer og gennemførsel af tests til specifikke undersøgelsesfelter. Et planlagt bachelorprojekt, hvor de studerende...... af evidensen af den fysioterapeutiske behandling, medfødte et ønske om inddragelse af egnede elektroniske undersøgelsesredskaber og spørgeskemaer. Med udgangspunkt i dette initierede fysioterapiuddannelsen, UCN, indeværende projekt i samarbejde med software firmaet DIGIfys. Formål: At videreudvikle...... den elektroniske journalplatform DIGIfys, ved at skabe mulighed for at indsamle undersøgelsesfund i kombination med behandlingsinterventioner igennem udvælgelse og implementering af de – ifølge litteraturen - bedst egnede validerede spørgeskemaer. Metode og Resultater: Undervisere på...

  15. Gastrointestinal Bleeding in Patients With Atrial Fibrillation Treated With Rivaroxaban or Warfarin: ROCKET AF Trial.

    Science.gov (United States)

    Sherwood, Matthew W; Nessel, Christopher C; Hellkamp, Anne S; Mahaffey, Kenneth W; Piccini, Jonathan P; Suh, Eun-Young; Becker, Richard C; Singer, Daniel E; Halperin, Jonathan L; Hankey, Graeme J; Berkowitz, Scott D; Fox, Keith A A; Patel, Manesh R

    2015-12-01

    Gastrointestinal (GI) bleeding is a common complication of oral anticoagulation. This study evaluated GI bleeding in patients who received at least 1 dose of the study drug in the on-treatment arm of the ROCKET AF (Rivaroxaban Once-daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation) trial. The primary outcome was adjudicated GI bleeding reported from first to last drug dose + 2 days. Multivariable modeling was performed with pre-specified candidate predictors. Of 14,236 patients, 684 experienced GI bleeding during follow-up. These patients were older (median age 75 years vs. 73 years) and less often female. GI bleeding events occurred in the upper GI tract (48%), lower GI tract (23%), and rectum (29%) without differences between treatment arms. There was a significantly higher rate of major or nonmajor clinical GI bleeding in rivaroxaban- versus warfarin-treated patients (3.61 events/100 patient-years vs. 2.60 events/100 patient-years; hazard ratio: 1.42; 95% confidence interval: 1.22 to 1.66). Severe GI bleeding rates were similar between treatment arms (0.47 events/100 patient-years vs. 0.41 events/100 patient-years; p = 0.39; 0.01 events/100 patient-years vs. 0.04 events/100 patient-years; p = 0.15, respectively), and fatal GI bleeding events were rare (0.01 events/100 patient-years vs. 0.04 events/100 patient-years; 1 fatal events vs. 5 fatal events total). Independent clinical factors most strongly associated with GI bleeding were baseline anemia, history of GI bleeding, and long-term aspirin use. In the ROCKET AF trial, rivaroxaban increased GI bleeding compared with warfarin. The absolute fatality rate from GI bleeding was low and similar in both treatment arms. Our results further illustrate the need for minimizing modifiable risk factors for GI bleeding in patients on oral anticoagulation. Copyright © 2015 American College of Cardiology Foundation. Published by

  16. Use and Outcomes of Antiarrhythmic Therapy in Patients with Atrial Fibrillation Receiving Oral Anticoagulation: Results from the ROCKET AF Trial

    Science.gov (United States)

    Steinberg, Benjamin A.; Hellkamp, Anne S.; Lokhnygina, Yuliya; Halperin, Jonathan L.; Breithardt, Günter; Passman, Rod; Hankey, Graeme J.; Patel, Manesh R.; Becker, Richard C.; Singer, Daniel E.; Hacke, Werner; Berkowitz, Scott D.; Nessel, Christopher C.; Mahaffey, Kenneth W.; Fox, Keith A.A.; Califf, Robert M.; Piccini, Jonathan P.

    2014-01-01

    Background Antiarrhythmic drugs (AAD) and anticoagulation are mainstays of atrial fibrillation (AF) treatment. Objective We aimed to study the use and outcomes of AAD therapy in anticoagulated AF patients. Methods Patients in the ROCKET AF trial (n=14,264) were grouped by AAD use at baseline: amiodarone, other AAD, or no AAD. Multivariable adjustment was performed to compare stroke, bleeding, and death across groups, as well as across treatment assignment (rivaroxaban or warfarin). Results Of 14,264 patients randomized, 1681 (11.8%) were treated with an AAD (1144 [8%] with amiodarone, 537 [3.8%] with other AADs). Amiodarone-treated patients were less-often female (38% vs. 48%), had more persistent AF (64% vs. 40%), and more concomitant heart failure (71% vs. 41%) than patients receiving other AADs. Patients receiving no AAD more closely-resembled amiodarone-treated patients. Time in therapeutic range was significantly lower in warfarin-treated patients receiving amiodarone versus no AAD (50% vs. 58%, p<0.0001). Compared with no AAD, neither amiodarone (adjusted HR 0.98, 95% CI 0.74–1.31, p=0.9) nor other AADs (adjusted HR 0.66, 95% CI 0.37–1.17, p=0.15) were associated with increased mortality. Similar results were observed for embolic and bleeding outcomes. Rivaroxaban treatment effects in patients not on an AAD were consistent with the overall trial (primary endpoint adjusted HR 0.82, 95% CI 0.68–0.98, pinteraction=0.06; safety endpoint adjusted HR 1.12, 95% CI 0.90–1.24, pinteraction=0.33). Conclusion Treatment with AADs was not associated with increased morbidity or mortality in anticoagulated patients with AF. The influence of amiodarone on outcomes in patients receiving rivaroxaban requires further study. PMID:24833235

  17. Two-year outcomes of patients with newly diagnosed atrial fibrillation: results from GARFIELD-AF

    Science.gov (United States)

    Bassand, Jean-Pierre; Accetta, Gabriele; Camm, Alan John; Cools, Frank; Fitzmaurice, David A.; Fox, Keith A.A.; Goldhaber, Samuel Z.; Goto, Shinya; Haas, Sylvia; Hacke, Werner; Kayani, Gloria; Mantovani, Lorenzo G.; Misselwitz, Frank; ten Cate, Hugo; Turpie, Alexander G.G.; Verheugt, Freek W.A.; Kakkar, Ajay K.

    2016-01-01

    Abstract Aims The relationship between outcomes and time after diagnosis for patients with non-valvular atrial fibrillation (NVAF) is poorly defined, especially beyond the first year. Methods and results GARFIELD-AF is an ongoing, global observational study of adults with newly diagnosed NVAF. Two-year outcomes of 17 162 patients prospectively enrolled in GARFIELD-AF were analysed in light of baseline characteristics, risk profiles for stroke/systemic embolism (SE), and antithrombotic therapy. The mean (standard deviation) age was 69.8 (11.4) years, 43.8% were women, and the mean CHA2DS2-VASc score was 3.3 (1.6); 60.8% of patients were prescribed anticoagulant therapy with/without antiplatelet (AP) therapy, 27.4% AP monotherapy, and 11.8% no antithrombotic therapy. At 2-year follow-up, all-cause mortality, stroke/SE, and major bleeding had occurred at a rate (95% confidence interval) of 3.83 (3.62; 4.05), 1.25 (1.13; 1.38), and 0.70 (0.62; 0.81) per 100 person-years, respectively. Rates for all three major events were highest during the first 4 months. Congestive heart failure, acute coronary syndromes, sudden/unwitnessed death, malignancy, respiratory failure, and infection/sepsis accounted for 65% of all known causes of death and strokes for <10%. Anticoagulant treatment was associated with a 35% lower risk of death. Conclusion The most frequent of the three major outcome measures was death, whose most common causes are not known to be significantly influenced by anticoagulation. This suggests that a more comprehensive approach to the management of NVAF may be needed to improve outcome. This could include, in addition to anticoagulation, interventions targeting modifiable, cause-specific risk factors for death. Clinical Trial Registration http://www.clinicaltrials.gov. Unique identifier: NCT01090362. PMID:27357359

  18. Effekten af cellebehandling hos patienter med kronisk iskæmisk hjertesygdom--en gennemgang af et Cochranereview

    DEFF Research Database (Denmark)

    Mathiasen, Anders Bruun; Qayyum, Abbas Ali; Kastrup, Jens

    2015-01-01

    The present Cochrane review included 23 studies randomized placebo-controlled clinical trials with a total of 1,255 patients. The effect of autologous cell therapy versus placebo was examined on left ventricular ejection fraction (LVEF), adverse effects and mortality in patients with chronic isch...

  19. Studie af den amerikanske doktrin for Counterinsurgency

    DEFF Research Database (Denmark)

    Møller, Nicolai Stahlfest

    2006-01-01

    Specialet omhandler den amerikanske doktrin for Counter-insurgency under den givne overordnede problemstilling asymmetri. Erfaringerne fra Irak og Afghanistan har forårsaget den nyskrivning af doktrinen, som behandles efterfølgende. Doktrinen er potentielt interessant for Danmark, grundet valget af...... strategisk partner, og den mulige indsættelse i missioner, hvor kontakt med, og måske bekæmpelse af, fjendtlige oprørsbevægelser vil forekomme. Maos teori og den nyere radikale islams teori ses som værende repræsentative for oprørsbevægelser ift. både amerikanske erfaringer og det forventede danske...... synes også at være udtalt i imødegåelsen af radikal islam, hvilket er en stor udfordring for både militære og civile myndigheder og organisationer. For at fungere som COIN enhed kræver det veluddannede enheder, da de udover de basale soldateropgaver også skal kunne støtte ifm. CIMIC opgaver, løsning af...

  20. Role of LncRNA-AF085935, IL-10 and IL-17 in Rheumatoid Arthritis Patients With Chronic Hepatitis C.

    Science.gov (United States)

    Sabry, Dina; Elamir, Azza; Mahmoud, Rania Hosny; Abdelaziz, Ahmed Ali; Fathy, Wael

    2017-05-01

    The current study aimed at testing the effect of corticosteroid therapy on serum levels of interleukin-10 (IL-10) and IL-17 as well as lncRNA-AF085935 in patients of rheumatoid arthritis (RA) associated with hepatitis C virus (HCV) and evaluating the usefulness of using these parameters to predict the therapeutic efficacy of steroids in these patients. Thirty healthy control subjects and 65 chronic HCV patients with RA were included in our study. Patients were subjected to clinical examination, abdominal ultrasound, and liver biopsy and received 6-methyl-prednisolone (PDN) 16 mg/day for 48 weeks. Blood samples were collected from all subjects and serum was separated to assess IL-10 and IL-17 by ELISA and HCV RNA and lncRNA-AF085935 by qRT-PCR. Our study revealed that there were significant increases in serum levels of IL-10, IL-17 and lncRNA-AF085935 in RA patients associated with HCV compared with healthy control subjects. Also there were significant increases in serum levels of IL-10 and HCV RNA and a significant decrease in serum level of IL-17 in patients after corticosteroid therapy, while lncRNA-AF085935 is not significantly changed. LncRNA-AF085935 might be a useful candidate biomarker for the early detection of RA associated with HCV, providing potential new strategies for early screening and therapy of these patients. IL-17 is a non-invasive prognostic marker to predict the efficacy of corticosteroid therapy in RA patients associated with chronic hepatitis C.

  1. An illness-specific version of the Revised Illness Perception Questionnaire in patients with persistent atrial fibrillation (AF-IPQ-R): Unpacking beliefs about treatment control, personal control and symptom triggers.

    OpenAIRE

    Taylor, Elaina Charlotte; O'Neill, Mark; Hughes, Lyndsay Dawn; Moss-Morris, Rona

    2017-01-01

    Objective: This study modified the Revised Illness Perception Questionnaire (IPQ-R) in patients with persistent Atrial Fibrillation (AF).Design: Qualitative interviews and think-aloud techniques informed modification of the IPQ-R to be specific to AF patients. Confirmatory Factor Analysis (CFA) (n=198) examined the validity of the modified IPQ-R (AF-IPQ-R). Exploratory Factor Analysis (EFA) examined the new AF-triggers scale. Construct validity examined associations between the AF-IPQ-R, qual...

  2. Der mangler undersøgelser af effekten af psykologbehandling til patienter med kræft og depression

    DEFF Research Database (Denmark)

    Johnsen, Anna Thit; Ross, Lone; Guldin, Mai-Britt

    2016-01-01

    Depression is a well-known co-morbidity of cancer. A possible intervention for depression is psychological treatment defined as psychotherapy provided by a psychologist. In this narrative review we investigated the effect of psychological treatment on depression for patients with cancer. Six...... Cochrane reviews of 38 studies investigating psychological or psychosocial interventions were reviewed. One of the 38 studies could not be assessed. None of the included studies investigated psychological treatment for patients who were diagnosed with depression or included because of depression symptoms....

  3. Koffein som adjuverende analgetikum til behandling af akutte smerter – en gennemgang af et Cochranereview

    DEFF Research Database (Denmark)

    Nikolajsen, Lone; Haroutiunian, Simon

    2013-01-01

    Based on 19 studies (7,238 participants) a Cochrane review concludes that the addition of caffeine to an analgesic drug provides superior analgesia compared with the analgesic drug alone. The benefit is small, with a number needed to treat of approx. 16. The use of analgesics containing caffeine...... is associated with an increased risk of the development of physical dependence, overuse headache, and withdrawal symptoms upon abrupt discontinuation. Combination analgesics with caffeine should only be used temporarily and exclusively for the treatment of acute pain conditions....

  4. Ultralydskanning ved diagnostik og behandling af hoftedysplasi. Vurdering af en selektiv screeningsprocedure

    DEFF Research Database (Denmark)

    Strandberg, C.; Konradsen, L.A.; Ellitsgaard, N.

    2008-01-01

    INTRODUCTION: With the intention of reducing the treatment frequency of Developmental Dysplasia of the Hip (DDH), two hospitals in Copenhagen implemented a screening and treatment procedure based on selective referral to ultrasonography of the hip (US). This paper describes and evaluates the proc......INTRODUCTION: With the intention of reducing the treatment frequency of Developmental Dysplasia of the Hip (DDH), two hospitals in Copenhagen implemented a screening and treatment procedure based on selective referral to ultrasonography of the hip (US). This paper describes and evaluates...... the procedure. MATERIALS AND METHODS: The procedure defines procedures for referral, diagnosis, treatment and follow-up of DDH. From 1998 to 2003 children with risk factors or with positive Ortolanis or Barlows test were referred to US. RESULTS: The treatment rate was 0.47%, and the rate of late diagnosed cases...... of the outcome of minor dysplastic/NFD hips must be based on a minimum of two US. An individualization of the treatment length was possible, and treatment length could be shortened in many cases. Compared with the incidence of DDH in Gentofte Hospital before the use of US, we suggest that this selective...

  5. Behandling med dopaminagonister i den tidlige fase af Parkinsons sygdom: gennemgang af et Cochrane-review

    DEFF Research Database (Denmark)

    Bode, Matthias

    2009-01-01

    The Cochrane analysis confirms some well-known facts: initial therapy with dopamine agonists (DA) delays the incidence of motor complications, but is associated with inferior motor control and a higher frequency of non-motor adverse events (AE) compared with levodopa. Some serious AE are missing...

  6. Systemisk prokinetisk behandling af postoperativ ileus efter abdominalkirurgi. Gennemgang af et Cochrane-review

    DEFF Research Database (Denmark)

    Holte, Kathrine

    2010-01-01

    Based on the evidence presented in the Cochrane review "Systemic prokinetic pharmacologic treatment for postoperative adynamic ileus following abdominal surgery in adults", routine administration of systemic prokinetics for the prevention of postoperative ileus is not recommendable. The potential...... of selective opioid antagonists and intravenous lidocaine should be further investigated, particularly in conjunction with laparoscopic surgery, epidural pain management and fast-track surgery....

  7. Behandling af placenta percreta kræver involvering af flere specialer

    DEFF Research Database (Denmark)

    Clausen, Caroline; Lönn, Lars; Albrechtsen, Charlotte Krebs

    2011-01-01

    Placenta percreta is a rare life-threatening obstetrical condition, often resulting in severe haemorrhage and hysterectomy. The incidence seems to be increasing, probably secondary to the increase in caesarean section rates. We present a protocol for an elective multidisciplinary approach...

  8. Ultralydskanning ved diagnostik og behandling af hoftedysplasi. Vurdering af en selektiv screeningsprocedure

    DEFF Research Database (Denmark)

    Strandberg, Charlotte; Konradsen, Lars Aage Glud; Ellitsgaard, Niels

    2008-01-01

    With the intention of reducing the treatment frequency of Developmental Dysplasia of the Hip (DDH), two hospitals in Copenhagen implemented a screening and treatment procedure based on selective referral to ultrasonography of the hip (US). This paper describes and evaluates the procedure....

  9. Behandling af placenta percreta kræver involvering af flere specialer

    DEFF Research Database (Denmark)

    Clausen, Caroline; Lönn, Lars; Albrechtsen, Charlotte Krebs

    2011-01-01

    Placenta percreta is a rare life-threatening obstetrical condition, often resulting in severe haemorrhage and hysterectomy. The incidence seems to be increasing, probably secondary to the increase in caesarean section rates. We present a protocol for an elective multidisciplinary approach with pr...

  10. Population pharmacokinetics and pharmacodynamics of rivaroxaban in patients with non-valvular atrial fibrillation: results from ROCKET AF.

    Science.gov (United States)

    Girgis, I G; Patel, M R; Peters, G R; Moore, K T; Mahaffey, K W; Nessel, C C; Halperin, J L; Califf, R M; Fox, K A A; Becker, R C

    2014-08-01

    Two once-daily rivaroxaban dosing regimens were compared with warfarin for stroke prevention in patients with non-valvular atrial fibrillation in ROCKET AF: 20 mg for patients with normal/mildly impaired renal function and 15 mg for patients with moderate renal impairment. Rivaroxaban population pharmacokinetic (PK)/pharmacodynamic (PD) modeling data from ROCKET AF patients (n = 161) are reported and are used to confirm established rivaroxaban PK and PK/PD models and to re-estimate values of the models' parameters for the current AF population. An oral one-compartment model with first-order absorption adequately described rivaroxaban PK. Age, renal function, and lean body mass influenced the PK model. Prothrombin time and prothrombinase-induced clotting time exhibited a near-linear relationship with rivaroxaban plasma concentration; inhibitory effects were observed through to 24 hours post-dose. Rivaroxaban plasma concentration and factor Xa activity had an inhibitory maximum-effect (Emax ) relationship. Renal function (on prothrombin time; prothrombinase-induced clotting time) and age (on factor Xa activity) had moderate effects on PK/PD models. PK and PK/PD models were shown to be adequate for describing the current dataset. These findings confirm the modeling and empirical results that led to the selection of doses tested against warfarin in ROCKET AF. © 2014, The American College of Clinical Pharmacology.

  11. Mobile Health Technology for Atrial Fibrillation Management Integrating Decision Support, Education, and Patient Involvement: mAF App Trial.

    Science.gov (United States)

    Guo, Yutao; Chen, Yundai; Lane, Deirdre A; Liu, Lihong; Wang, Yutang; Lip, Gregory Y H

    2017-12-01

    Mobile Health technology for the management of patients with atrial fibrillation is unknown. The simple mobile AF (mAF) App was designed to incorporate clinical decision-support tools (CHA 2 DS 2 -VASc [Congestive heart failure, Hypertension, Age ≥75 years, Diabetes Mellitus, Prior Stroke or TIA, Vascular disease, Age 65-74 years, Sex category], HAS-BLED [Hypertension, Abnormal renal/liver function, Stroke, Bleeding history or predisposition, Labile INR, Elderly, Drugs/alcohol concomitantly], SAMe-TT 2 R 2 [Sex, Age App vs usual care) in a cluster randomized design pilot study. Patients' knowledge, quality of life, drug adherence, and anticoagulation satisfaction were evaluated at baseline, 1 month, and 3 months. Usability, feasibility, and acceptability of the mAF App were assessed at 1 month. A total of 113 patients were randomized to mAF App intervention (mean age, 67.4 years; 57.5% were male; mean follow-up, 69 days), and 96 patients were randomized to usual care (mean age, 70.9 years; 55.2% were male; mean follow-up, 95 days). More than 90% of patients reported that the mAF App was easy, user-friendly, helpful, and associated with significant improvements in knowledge compared with the usual care arm (P values for trend App versus usual care (all P App arm versus usual care, with anxiety and depression reduced (all P App, integrating clinical decision support, education, and patient-involvement strategies, significantly improved knowledge, drug adherence, quality of life, and anticoagulation satisfaction. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  12. Responders and nonresponders after catheter ablation procedure and antiarrhythmic drug therapy in patients with paroxysmal AF: data from implantable cardiac monitors

    Directory of Open Access Journals (Sweden)

    А. А. Симонян

    2016-11-01

    Full Text Available Aim. The aim of this study was to assess the number of responders and nonresponders after catheter ablation procedure and antiarrhythmic drug therapy (AAD in patients with paroxysmal AF through implantable cardiac monitors (ICM. Methods. 92 patients with paroxysmal AF were randomized into two groups: 1 AAD + ICM implantation (group I; n=46, and 2 AF catheter ablation (CA + ICM implantation (group II; n=46, and 2. Patients with an AF% < 0.5% were considered AF-free (responders. Patients with AF% > 0.5% were classified as nonresponders. The follow up of this study was 24 months.Results. At the end of the follow-up period 13 (28.3% patients in AAD group and 29 (63 % patients in CA group were responders (log-rank test; р=0.0009; HR 2,6; 95% CI [1.44-4.69], р=0.001, Cox regression. According to multivariate logistic regression analysis data, AF burden>4.5% during the first two months after treatment (odds ratio [OR]=38,9; 95% confidence interval [CI], 6.2–245; P<0.001, arterial hypertension (OR=12.7; 95% CI, 1.9–85.3; P=0.009 and AF duration more than 5 years (OR=8.5; 95% CI, 1.04–69.6; P=0.044 were independent predictors of AF burden progression Conclusion. According to implantable cardiac monitors data, in patients with paroxysmal AF radiofrequency catheter ablation as compared to antiarrhythmic drug therapy results in higher percentage of responders.Received 10 July 2016. Accepted 22 August 2016.Funding: The study had no sponsorship. Conflict of interest: The authors declare no conflict of interest.

  13. Preventive AF ablation in patients with mitral valve lesion and left atrium enlargement: 3-month follow-up results

    Directory of Open Access Journals (Sweden)

    A. V. Bogachev-Prokophiev

    2017-07-01

    Full Text Available Aim. Persistence or appearance of atrial fibrillation (AF after mitral valve surgery significantly reduces the number of excellent and good results in the long-term period. AF leads to heart failure and pulmonary hypertension and increases the risk of thromboembolic events and stroke. Drug strategies for prevention of new-onset AF in the postoperative period are well developed, while invasive methods are still under development and clinical trials. This study aims to evaluate the safety and efficacy of surgical prevention of atrial fibrillation in patients with left atrium enlargement and mitral valve (MV lesion at 3-month follow-up.Methods. Forty patients operated in our clinic over a period of 2015–2017 were included in the study. All patients had MV lesion and left atrial dilatation greater than 60 mm. All patients had a sinus rhythm at the time of the operation and no documented AF in the history. The mean age of the patients was 48.9±10.1 (23-69 years. All patients had indications for mitral valve surgery and were randomized into two groups. The first group included patients who underwent a concomitant preventive ablation procedure (n = 20. The second group included patients with isolated MV surgery (n = 20. Complications and heart rhythm were evaluated within 3 months after surgery.Results. Patients who underwent preventive ablation within 3 months after the surgery did not differ significantly in the number of complications as compared with the control. In the group of patients with preventive ablation, a higher freedom from AF in comparison with the group of patients with isolated MV surgery was observed: 95 vs. 40%, respectively. Conclusion. Preventive atrial fibrillation ablation in patients with mitral valve lesion and left atrium enlargement is a safe and effective procedure. Preventive ablation reduces the risk of atrial fibrillation by 1.6 times within 3-month follow-up.Received 24 April 2017. Accepted 28 June 2017.Funding: The

  14. Behandling af akut myeloid leukæmi uden transfusion af blodprodukter hos et medlem af Jehovas Vidner

    DEFF Research Database (Denmark)

    Larsen, Christian; Jensen, Morten Krogh

    2011-01-01

    We present a case in which a young woman was diagnosed with acute myeloid leukaemia, FAB-classification type M2. As a member of Jehovah's Witnesses she refused to accept any treatment involving blood transfusions. A modified induction and consolidation chemotherapy regimen was applied, tailored...... to reduce prolonged myelosuppression. Despite severe anaemia, she survived to achieve complete remission. She is currently under treatment-free observation after two courses of consolidation treatment....

  15. Behandling af akut myeloid leukæmi uden transfusion af blodprodukter hos et medlem af Jehovas Vidner

    DEFF Research Database (Denmark)

    Larsen, Christian; Jensen, Morten Krogh

    2011-01-01

    We present a case in which a young woman was diagnosed with acute myeloid leukaemia, FAB-classification type M2. As a member of Jehovah's Witnesses she refused to accept any treatment involving blood transfusions. A modified induction and consolidation chemotherapy regimen was applied, tailored...

  16. Nyrearteriestenose--diagnostik og behandling

    DEFF Research Database (Denmark)

    Pedersen, Erling Bjerregaard; Andersen, Ulrik Bjørn

    2009-01-01

    Screening for renal artery stenosis (RAS) should be restricted to patients with a high RAS risk. Captopril renography, computed tomography (CT)-angiography, magnetic resonance (MR)-angiography and ultrasound (US) Doppler can be used. Most patients should receive medical treatment. If predictive...

  17. Kirurgisk behandling ved lokalavanceret pancreascancer

    DEFF Research Database (Denmark)

    Fristrup, Claus Wilki; Pless, Torsten; Hovendal, Claus

    2009-01-01

    Treatment of patients with locally advanced pancreatic cancer remains a challenge, and the exact role of surgery with vascular resection remains unclear. Several studies on selected patient populations have addressed the problem, but with varying results. Although venous resection may be performe...

  18. Skal alkoholmisbrug overhovedet behandles i almen praksis

    DEFF Research Database (Denmark)

    Barfod, Sverre Malm

    1995-01-01

    Som en del af en international undersøgelse gennemførtes telefon-interviews ud fra et semi-struktureret spørgeskema af 12 tilfældigt udvalgte praktiserende læger samt personlige interviews af seks nøglepersoner i sundhedsvæsenet. Alle de udspurgte praktiserende læger var interesserede i at udføre...

  19. Self-observation of total life situation in patients with Acromegalia

    DEFF Research Database (Denmark)

    Jensen, Jonna Gintberg

      36 patienters selviagttagelser af lidelser og livskvalitet i forbindelse med sygdommen akromegali.  Baggrund Akromegali er en kronisk sygdom fordrende livslang kontrol. Ca. 350 danskere har diagnosticeret akromegali. Det er vanskeligt for patientgruppen at finde oplysninger om sygdommen....... Litteratursøgning i 2006 tydeliggjorde ingen undersøgelser af, hvordan patienter selv iagttager deres situation. I indlæggelsesafsnittet var en instruks for den instrumentelle sygepleje, men ingen klinisk retningslinje, patientinformation eller vejledende plejeplan. På den baggrund formuleredes forskningsspørgsmålet......: ‘Hvordan iagttager patienter med akromegali selv deres livssituation, livskvalitet samt den sygepleje og behandling de får i forbindelse med kontrol-indlæggelser?'   Hensigt At afdække patienternes syn på: Hvordan det har været at leve med en sygdom i utallige år (sygdomslidelse)? Hvordan de iagttager...

  20. Forebyggelse af dyb venetrombose (DVT) i underekstremiteter hos voksne hospitalsindlagte patienter gennem mobilisering

    DEFF Research Database (Denmark)

    Jensen, Jonna Gintberg

    2011-01-01

    strømper, men som et veldokumenteret supplement. Metode: Et litteratur studie med det fokuserede spørgsmål: Kan tidlig mobilisering reducere forekomsten af DVT i underekstremiteterne hos voksne. Systematiske søgninger blev foretaget i: PubMed, Cochrane, Embase, Cinahl og Trip. Litteratursøgningen afdækkede...

  1. Hypertension--forekomst og behandling

    DEFF Research Database (Denmark)

    Ibsen, Hans; Jørgensen, Torben; Jensen, Gorm B

    2009-01-01

    Hypertension is the most important modifiable risk factor for cardiovascular disease. However, less than half of all hypertensives have their blood pressure reduced to relevant goals. The prevalence of hypertension in Denmark was found to be between 26% and 40% of the adult population. Just over ...... half were aware of the diagnosis, but less than half were in treatment. Blood pressure control in patients who are undergoing treatment has improved during recent years, but there is still a gap to achievable control rates....

  2. Pneumocystepneumoni ved behandling med infliximab

    DEFF Research Database (Denmark)

    Josephson, Maria Eklund; Kristensen, Lena Hagelskjaer; Andersen, Vibeke

    2008-01-01

    The treatment of ulcerative colitis has improved since the appearance of Tumor Necrosis Factor (TNF)-alpha inhibitors. However, the use of TNF-alpha inhibitors increases the risk of opportunistic infections. We describe two cases of Pneumocystis jiroveci pneumonia during infliximab therapy...... for active ulcerative colitis. They were successfully treated with sulfametoxazole/trimetroprim. High awareness of P. jiroveci pneumonia in patients who develop pulmonary symptoms with hypoxia during TNF-alpha modulator therapy is recommended....

  3. Hypertension--forekomst og behandling

    DEFF Research Database (Denmark)

    Ibsen, Hans; Jørgensen, Torben; Jensen, Gorm B

    2009-01-01

    Hypertension is the most important modifiable risk factor for cardiovascular disease. However, less than half of all hypertensives have their blood pressure reduced to relevant goals. The prevalence of hypertension in Denmark was found to be between 26% and 40% of the adult population. Just over ...... half were aware of the diagnosis, but less than half were in treatment. Blood pressure control in patients who are undergoing treatment has improved during recent years, but there is still a gap to achievable control rates. Udgivelsesdato: 2009-Jun-8...

  4. Alternative calculations of individual patient time in therapeutic range while taking warfarin: results from the ROCKET AF trial.

    Science.gov (United States)

    Singer, Daniel E; Hellkamp, Anne S; Yuan, Zhong; Lokhnygina, Yuliya; Patel, Manesh R; Piccini, Jonathan P; Hankey, Graeme J; Breithardt, Günter; Halperin, Jonathan L; Becker, Richard C; Hacke, Werner; Nessel, Christopher C; Mahaffey, Kenneth W; Fox, Keith A A; Califf, Robert M

    2015-03-03

    In the ROCKET AF (Rivaroxaban-Once-daily, oral, direct Factor Xa inhibition Compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation) trial, marked regional differences in control of warfarin anticoagulation, measured as the average individual patient time in the therapeutic range (iTTR) of the international normalized ratio (INR), were associated with longer inter-INR test intervals. The standard Rosendaal approach can produce biased low estimates of TTR after an appropriate dose change if the follow-up INR test interval is prolonged. We explored the effect of alternative calculations of TTR that more immediately account for dose changes on regional differences in mean iTTR in the ROCKET AF trial. We used an INR imputation method that accounts for dose change. We compared group mean iTTR values between our dose change-based method with the standard Rosendaal method and determined that the differences between approaches depended on the balance of dose changes that produced in-range INRs ("corrections") versus INRs that were out of range in the opposite direction ("overshoots"). In ROCKET AF, the overall mean iTTR of 55.2% (Rosendaal) increased up to 3.1% by using the dose change-based approach, depending on assumptions. However, large inter-regional differences in anticoagulation control persisted. TTR, the standard measure of control of warfarin anticoagulation, depends on imputing daily INR values for the vast majority of follow-up days. Our TTR calculation method may better reflect the impact of warfarin dose changes than the Rosendaal approach. In the ROCKET AF trial, this dose change-based approach led to a modest increase in overall mean iTTR but did not materially affect the large inter-regional differences previously reported. URL: ClinicalTrials.gov. Unique identifier: NCT00403767. © 2015 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

  5. Anmeldelse af Ulrik Rammeskow Bang-Pedersen, Lasse Højlund Christensen, Kim Sommer Jensen, Christian Jul Madsen & Andreas Kærsgaard Mylin: Rekonstruktion – teori og praksis (2011)

    DEFF Research Database (Denmark)

    Werlauff, Erik

    2011-01-01

    Artiklen anmelder det nævnte værk, som i detaljer behandler lov nr. 718 af 25. juni 2010, der indførte regler i konkursloven, som muliggør rekonstruktion af både fysiske og juridiske personer med henblik på virksomhedsoverdragelse og tvangsakkord, og således at skyldneren ikke selv kan standse re...

  6. Effect of ColchiciNe on the InciDence of Atrial Fibrillation in Open Heart Surgery Patients: END-AF Trial.

    Science.gov (United States)

    Tabbalat, Ramzi A; Hamad, Nidal M; Alhaddad, Imad A; Hammoudeh, Ayman; Akasheh, Bassam F; Khader, Yousef

    2016-08-01

    Atrial fibrillation (AF) is a common arrhythmia in patients undergoing cardiac surgery and may result in significant morbidity and increased hospital stay. This study was conducted to determine if colchicine administered preoperatively to patients undergoing cardiac surgery and continued during hospitalization is effective in reducing the incidence of postoperative AF. In this multicenter prospective randomized open-label study, consecutive patients with no history of AF and scheduled to undergo elective cardiac surgery (n = 360) were randomized to colchicine (n = 179) or no-colchicine (n = 181). Main exclusion criteria were history of AF or supraventricular arrhythmias or absence of sinus rhythm at enrolment, and contraindications to colchicine. Colchicine was orally administered 12 to 24 hours preoperatively and continued until hospital discharge. The primary efficacy end point was documented AF lasting more than 5 minutes. Safety end point was colchicine adverse effects. In-hospital mortality was 3.3%. The primary end point of AF occurred in 63 patients (17.5%): 26 (14.5%) in the colchicine group and 37 (20.5%) in the no-colchicine group (relative risk reduction 29.3% [P = .14]). Diarrhea occurred in 54 patients, 44 (24.6%) on colchicine and 10 (5.5%) on no-colchicine (P colchicine in 23 (52%) of the 44 patients. Colchicine administered preoperatively to patients undergoing cardiac surgery and continued until hospital discharge failed to significantly reduce the incidence of early postoperative AF. Diarrhea was the most common adverse effect of colchicine leading to its discontinuation in more than half of the patients with this adverse effect. Copyright © 2016 Elsevier Inc. All rights reserved.

  7. Coaching patients to self-care: a primary responsibility of nursing

    DEFF Research Database (Denmark)

    Hørdam, Britta

    2010-01-01

    Anmelselse af international forskning:Formål: En australsk undersøgelse har fokus på aktivt at støtte og guide ældre til en rehabiliterende egenomsorg efter udskrivelse fra behandling på sygehus. Metode: Med afsæt i grounded theory udvikles en model for rehabiliterende sygepleje, hvor sygeplejers...

  8. Management of major bleeding events in patients treated with rivaroxaban vs. warfarin: results from the ROCKET AF trial.

    Science.gov (United States)

    Piccini, Jonathan P; Garg, Jyotsna; Patel, Manesh R; Lokhnygina, Yuliya; Goodman, Shaun G; Becker, Richard C; Berkowitz, Scott D; Breithardt, Günter; Hacke, Werner; Halperin, Jonathan L; Hankey, Graeme J; Nessel, Christopher C; Mahaffey, Kenneth W; Singer, Daniel E; Califf, Robert M; Fox, Keith A A

    2014-07-21

    There are no data regarding management and outcomes of major bleeding events in patients treated with oral factor Xa inhibitors. Using data from ROCKET AF, we analysed the management and outcomes of major bleeding overall and according to the randomized treatment. During a median follow-up of 1.9 years, 779 (5.5%) patients experienced major bleeding at a rate of 3.52 events/100 patient-years with a similar event rate in each arm (n = 395 rivaroxaban vs. n = 384 warfarin). The median number of transfused packed red blood cells (PRBC) per episode was similar in both arms [2 (25th, 75th: 2, 4) units]. Overall, few transfusions of whole blood (n = 14), platelets (n = 10), or cryoprecipitate (n = 2) were used. Transfusion of fresh frozen plasma (FFP) was significantly less in the rivaroxaban arm (n = 45 vs. n = 81 units) after adjustment for covariates [odds ratio (OR) 0.43 (95% CI 0.29-0.66); P ROCKET AF, the use of FFP and PCC was less among those allocated rivaroxaban compared with warfarin. However, use of PRBCs and outcomes after bleeding were similar among patients randomized to rivaroxaban or to warfarin. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2014. For permissions please email: journals.permissions@oup.com.

  9. An illness-specific version of the Revised Illness Perception Questionnaire in patients with atrial fibrillation (AF IPQ-R): Unpacking beliefs about treatment control, personal control and symptom triggers.

    Science.gov (United States)

    Taylor, Elaina C; O'Neill, Mark; Hughes, Lyndsay D; Moss-Morris, Rona

    2018-04-01

    This study modified the Revised Illness Perception Questionnaire (IPQ-R) in patients with persistent atrial fibrillation (AF). Qualitative interviews and think-aloud techniques informed modification of the IPQ-R to be specific to AF patients. Confirmatory Factor Analysis (CFA) (n = 198) examined the validity of the modified IPQ-R (AF-IPQ-R). Exploratory factor analysis (EFA) examined the new AF-triggers scale. Construct validity examined associations between the AF-IPQ-R, quality of life (QoL) and beliefs about medicines. Test-retest and internal reliability were examined. Interviews indicated that patients viewed triggers of AF rather than initial causes of illness as more applicable. Patients believed specific behaviours such as rest could control AF. Treatment control beliefs related to pharmacological and procedural treatments. These data were used to modify the IPQ-R subscales and to develop a triggers of AF scale. CFA indicated good model fit. EFA of the triggers scale indicated three factors: emotional; health behaviours; and over-exertion triggers. Expected correlations were found between the AF-IPQ-R, QoL and treatment beliefs, evidencing good construct validity. The AF-IPQ-R showed sound psychometric properties. It provides more detailed specification than the IPQ-R of beliefs that may help to understand poor QoL in AF patients, and guidance for future interventions in this area.

  10. Metodik til studiet af strategiske ledelsesprocesser i organisationer

    Directory of Open Access Journals (Sweden)

    Jørgen Gulddahl Rasmussen

    2010-10-01

    Full Text Available Denne artikel handler om at skabe viden om en hverdagspraksis, der sjældent er sat ord på. Den behandler de ledelsesprocesser, der i virksomheder producerer strategi og omsætter sådanne strategier i produktive handlinger. Det er processer, der i små og mellemstore virksomheder er præget af intuition og af meget uformelle samspil mellem virksomhedsledere og medarbejdere. Metodikken er en videreudvikling af de metoder til produktion af kvalitative data, som FIRM-gruppen har eksperimenteret med gennem nogle år. Artiklen kan ses som en afrapportering af et flerårigt metodeudviklingsarbejde. Da erfaringer fra sådanne virksomheder viser, at strategiske processer i høj grad udvikler sig gennem uformel kommunikation, og at lederes intuition spiller en meget stor rolle, arbejder metodikken med en struktureret udviklingsdialog mellem et mindre antal virksomhedsledere med strategiske opgaver og forskere. Denne udviklingsdialog har til formål at følge og forstå de processer, der skaber ledernes egne praksisrelaterede ”teorier” for strategisk handling. Efter en præsentation af temaet gennemgås metodikkens praktiske fremgangsmåde med undersøgelser i en række virksomheder, opbygning af cases i samarbejde med ledere fra disse virksomheder, diskussion af disse og foreløbige konklusioner hen mod de næste trin i metodikken. Artiklen er skrevet samtidigt med arbejdet på et igangværende forskningsprojekt og vil derfor både være en præsentation og en udvikling af muligheder og vanskeligheder i metodikken.

  11. Diagnostik af urinvejsinfektion i almen praksis

    DEFF Research Database (Denmark)

    Bjerrum, Lars; Grinsted, Per; Højbjerg, Tove

    2012-01-01

    Patienter med symptomer på urinvejsinfektion (UVI) tegner sig for 2-5% af alle kontakter i almen praksis, men kun omkring halvdelen af de patienter, der henvender sig i almen praksis med typiske symptomer, har signifi kant bakteriuri. Artiklen, der er skrevet af erfarne almenmedicinske klinikere og...

  12. Monitorering af fysisk aktivitetsniveau (MOAN) hos indlagte patienter på geriatrisk afdeling - forsøgsprotokol

    DEFF Research Database (Denmark)

    Villumsen, Morten; Jørgensen, Martin Grønbech; Andreasen, Jane

    genvinder disse igen.(1) Der er desuden god dokumentation for at også ældre patienter med demens kan forbedre funktionsniveau ved træning.(2) Særligt styrketræning af underekstremiteterne med høj intensitet, har vist sig at være effektivt. Hvilket blandt andet har kunnet registreres med ”Timed up and go...... udskrivelse? 2. At undersøge hvilken betydning tiden stående/gående har for ændringen i Barthel Index under indlæggelsen. Metode: Undersøgelsen gennemføres som et observationssstudie af aktivitetsniveau fra indlæggelse til udskrivelse for patienter indlagt på geriatrisk afdeling Aalborg sygehus. Timed up...... and Go (TUG), rejse-sætte sig testen og Barthel score registreres for alle patienter ved indlæggelse og udskrivelse. Øvrige oplysninger vedrørende alder, køn, vægt, højde, demens, depression, årsag til indlæggelse, boligform, og pårørende indhentes fra journalen. Primær outcome for undersøgelsen er den...

  13. Rivaroxaban in the Prevention of Stroke and Systemic Embolism in Patients with Non-Valvular Atrial Fibrillation: Clinical Implications of the ROCKET AF Trial and Its Subanalyses.

    Science.gov (United States)

    Spencer, Ryan J; Amerena, John V

    2015-12-01

    Atrial fibrillation (AF) is an increasingly common cause of stroke and systemic embolism. While warfarin has been the mainstay of stroke prevention in patients with AF, newer novel oral anticoagulant medications are now available. Rivaroxaban, a direct factor Xa inhibitor with a rapid onset and offset after oral administration, offers potential advantages over warfarin, predominantly due to its predictable pharmacokinetics across wide patient populations. It requires no coagulation monitoring, and only two different doses are needed (20 mg daily for patients with normal renal function and 15 mg daily in those with reduced renal function). A large randomized trial (ROCKET AF) has shown non-inferiority to warfarin for preventing stroke or systemic embolism in the per-protocol population and superiority to warfarin in the on-treatment safety population. Several subanalyses confirm that the treatment effect of rivaroxaban is consistent across different patient subgroups, including those with reduced renal function. The tolerability of rivaroxaban appears similar to that of warfarin, with comparable overall bleeding rates in clinical trials. In ROCKET AF, significantly lower rates of fatal and intracranial bleeding were seen with rivaroxaban, while lower rates of gastrointestinal bleeding were seen with warfarin. Important contraindications to rivaroxaban include valvular AF, the presence of a prosthetic valve (mechanical or bioprosthetic) or valve repair, the need for concurrent dual antiplatelet therapy, and creatinine clearance <30 ml/min. Once-daily dosing and the lack of coagulation monitoring may increase utilization and adherence compared with warfarin, potentially decreasing the large burden of care associated with stroke secondary to AF. Overall, rivaroxaban offers a useful alternative to warfarin for stroke prevention in patients with AF.

  14. Usefulness of limited echocardiography with A-F mnemonic in patients with suspected non‑ST-segment elevation acute coronary syndrome.

    Science.gov (United States)

    Sobczyk, Dorota; Nycz, Krzysztof; Żmudka, Krzysztof

    2014-01-01

    When diagnosing the causes of acute chest pain, both acute coronary syndromes (ACSs) and other serious conditions should be considered. The aim of the study was to assess the usefulness of limited transthoracic echocardiography (TTE) with an A-F mnemonic in patients with suspected non-ST-segement elevation ACS (NSTE-ACS) and the effect of TTE on therapeutic decisions. This retrospective study was conducted at an emergency department for 12 months. The study population consisted of consecutive patients with a preliminary diagnosis of NSTE-ACS. We analyzed demographic data, clinical condition, medical history, electrocardiography, TTE, and the levels of necrotic markers. TTE with the A-F mnemonic was performed within 15 minutes from admission. A total of 916 consecutive patients were enrolled to the study. The diagnosis of ACS was confirmed in 70.19% of the patients. TTE with the A-F mnemonic revealed regional wall motion abnormalities in 74.03% of the ACS group and significant echocardiographic abnormalities in 2.18% of the ACS group and 55.31% of patients without ACS. On the basis of those findings, 4.69% of the patients underwent invasive treatment other than myocardial revascularization. A comparative analysis revealed that patients with ACS were older, more likely to have ST-segment depression, higher levels of necrotic markers, and lower left ventricular ejection fraction, while patients without ACS had more echocardiographic abnormalities in points B-F according to the A-F scheme. Limited TTE with the A-F mnemonic should be performed in all patients with suspected NSTE-ACS. It allows to confirm ischemia and detect other life-threatening conditions. TTE with the A-F mnemonic covers a sufficient spectrum of cardiac abnormalities and has a significant effect on therapeutic decision making in patients with suspected NSTE-ACS.  

  15. Overweight and obesity in patients with atrial fibrillation: Sex differences in 1-year outcomes in the EORP-AF General Pilot Registry.

    Science.gov (United States)

    Boriani, Giuseppe; Laroche, Cécile; Diemberger, Igor; Fantecchi, Elisa; Meeder, Joan; Kurpesa, Malgorzata; Baluta, Monica Mariana; Proietti, Marco; Tavazzi, Luigi; Maggioni, Aldo P; Lip, Gregory Y H

    2018-04-01

    The impact of overweight and obesity on outcomes in "real world" patients with atrial fibrillation (AF) is not fully defined. Second, sex differences in AF outcomes may also exist. The aim was to investigate outcomes at 1 year follow-up for AF patients enrolled in the EORP-AF Registry, according to BMI (kg/m 2 ), comparing patients with normal BMI (18.5 to obesity (≥ 30 kg/m 2 ), in relation to sex differences. Among 2,540 EORP AF patients (38.9% female; median age 69) with 1 year follow-up data available, 720 (28.3%) had a normal BMI, 1,084 (42.7%) were overweight, and 736 (29.0%) were obese. Obese patients were younger and with more prevalent diabetes mellitus and hypertension (P different according to BMI among female patients (9.3% normal BMI, 5.3% overweight, and 4.3 % obese, P = 0.023), but not among male patients (P = 0.748). The composite outcome of thromboembolic events and death was also significantly different, being lower in obese females (P = 0.035). Among male patients, bleeding events were significantly more frequent in obese subjects (P = 0.035). On multivariable Cox analysis, BMI was not independently associated with all-cause mortality. Among AF patients, overweight and obesity are common and associated with better outcomes in females (a finding previously reported as "obesity paradox"), while no significant differences in outcomes are detected among male patients. Final multivariable model found that increasing BMI was not associated with increased risk of all-cause death; conversely, age and comorbidities persisted as major determinants. © 2018 Wiley Periodicals, Inc.

  16. Efficacy and safety of rivaroxaban compared with warfarin in patients with carotid artery disease and nonvalvular atrial fibrillation: Insights from the ROCKET AF trial.

    Science.gov (United States)

    Kochar, Ajar; Hellkamp, Anne S; Lokhnygina, Yuliya; Jones, W Schuyler; Becker, Richard C; Berkowitz, Scott D; Breithardt, Günter; Fox, Keith A A; Halperin, Jonathan L; Hankey, Graeme J; Mahaffey, Kenneth W; Nessel, Christopher C; Singer, Daniel E; Piccini, Jonathan P; Patel, Manesh R

    2018-01-01

    Atrial fibrillation (AF) increases risk of stroke 5-fold. Carotid artery disease (CD) also augments the risk of stroke, yet there are limited data about the interplay of these 2 diseases and clinical outcomes in patients with comorbid AF and CD. Among patients with both AF and CD, use of rivaroxaban when compared with warfarin is associated with a lower risk of stroke. This post hoc analysis from ROCKET AF aimed to determine absolute rates of stroke/systemic embolism (SE) and bleeding, and the efficacy and safety of rivaroxaban compared with warfarin in patients with AF and CD (defined as history of carotid occlusive disease or carotid revascularization [endarterectomy and/or stenting]). A total of 593 (4.2%) patients had CD at enrollment. Patients with and without CD had similar rates of stroke or SE (adjusted hazard ratio [HR]: 0.99, 95% confidence interval [CI]: 0.66-1.48, P = 0.96), and there was no difference in major or nonmajor clinically relevant bleeding (adjusted HR: 1.04, 95% CI: 0.88-1.24, P = 0.62). The efficacy of rivaroxaban compared with warfarin for the prevention of stroke/SE was not statistically significant in patients with vs those without CD (interaction P = 0.25). The safety of rivaroxaban vs warfarin for major or nonmajor clinically relevant bleeding was similar in patients with and without CD (interaction P = 0.64). Patients with CD in ROCKET AF had similar risk of stroke/SE compared with patients without CD. Additionally, there was no interaction between CD and the treatment effect of rivaroxaban or warfarin for stroke prevention or safety endpoints. © 2018 Wiley Periodicals, Inc.

  17. OCD og orofaciale dyskinesier forårsaget af sjælden basalganglielidelse

    DEFF Research Database (Denmark)

    Elmgreen, Søren Bruno; Danielsen, Erik Hvid

    2014-01-01

    Bevægeforstyrrelser hos psykiatriske patienter skyldes sædvanligvis ekstrapyramidale bivirkninger til antipsykotisk medicin. Her beskrives en sjælden årsag til orofaciale dyskinesier, tungedystoni og koreiforme bevægelser hos en 31-årig mand i behandling for obsessiv-kompulsiv lidelse (OCD)....

  18. Drivers of hospitalization for patients with atrial fibrillation: Results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF).

    Science.gov (United States)

    Steinberg, Benjamin A; Kim, Sunghee; Fonarow, Gregg C; Thomas, Laine; Ansell, Jack; Kowey, Peter R; Mahaffey, Kenneth W; Gersh, Bernard J; Hylek, Elaine; Naccarelli, Gerald; Go, Alan S; Reiffel, James; Chang, Paul; Peterson, Eric D; Piccini, Jonathan P

    2014-05-01

    Atrial fibrillation (AF) is the most common cardiac dysrhythmia and contributes significantly to health care expenditures. We sought to assess the frequency and predictors of hospitalization in patients with AF. The ORBIT-AF registry is a prospective, observational study of outpatients with AF enrolled from June 29, 2010, to August 9, 2011. The current analysis included 9,484 participants with 1-year follow-up. Multivariable, logistic regression was used to identify baseline characteristics that were associated with first cause-specific hospitalization. Overall, 31% of patients with AF studied (n = 2,963) had 1 or more hospitalizations per year and 10% (n = 983) had 2 or more. The most common hospitalization cause was cardiovascular (20 per 100 patient-years vs 3.3 bleeding vs 17 noncardiovascular, nonbleeding). Compared with those not hospitalized, hospitalized patients were more likely to have concomitant heart failure (42% vs 28%, P heart failure, hypertension, age ≥75, or diabetes; 2 points for prior stroke or transient ischemic attack) scores (2.5 vs 2.2, P Heart Rhythm Association class severe symptoms 18% vs 13%, P heart failure (adjusted hazard ratio [HR] 1.57 for New York Heart Association III/IV vs none, P heart rate at baseline (adjusted HR 1.11 per 10-beats/min increase >66, P Heart Rhythm Association severe vs none, P heart failure and AF symptoms. Improved symptom control, rate control, and comorbid condition management should be evaluated as strategies to reduce health care use in these patients. Copyright © 2014 Mosby, Inc. All rights reserved.

  19. Validity of a 5-minute focused echocardiography with A-F mnemonic performed by non-echocardiographers in the management of patients with acute chest pain.

    Science.gov (United States)

    Sobczyk, Dorota; Nycz, Krzysztof; Andruszkiewicz, Pawel

    2015-03-26

    To validate the practicality of focused echocardiography with A-F mnemonic performed by non-specialists in patients with suspected acute coronary syndrome (ACS). This prospective observational study was conducted in the Emergency Room within 12 months period. Study population consisted of consecutive patients with preliminary diagnosis of an ACS. The following data were analyzed: demographics, clinical condition, medical history, ECG, transthoracic echocardiography (TTE) and levels of cardiac necrotic markers. TTE was performed within the first 15 minutes after the admission by the resident on-call. TTE images were interpreted and reported with mnemonic A-F. All studies were recorded and reviewed within 24 hours by the cardiologist. 1312 consecutive patients were enrolled to the study. TTE with A-F mnemonic revealed: RWMAs in 82.87% patients with confirmed ACS, other significant cardiac pathologies were found in 2.21% in ACS and 46.52% in non-ACS groups respectively. On the basis of these findings, 20 (1.92%) ACS and 29 (10.62%) non-ACS group patients underwent target operative treatment. Survey showed that both echocardiographic image acquisition and its interpretation with A-F mnemonic, took less than 5 minutes in 95% of cases. Residents found A-F mnemonic algorithm simple and useful. No differences were found in key findings between TTE performed by resident and the cardiologist. Focused echocardiography with A-F mnemonic allows both confirmation of acute myocardial ischemia and detection of the other life-threatening cardiac conditions resulting in proper bedside decision of directed treatment. Mnemonic based TTE enables reliable examination by properly trained residents.

  20. Comparison of the 2MACE and TIMI-AF Scores for Composite Clinical Outcomes in Anticoagulated Atrial Fibrillation Patients

    DEFF Research Database (Denmark)

    Pastori, Daniele; Rivera-Caravaca, José Miguel; Esteve-Pastor, María Asunción

    2018-01-01

    "clinically relevant events" (CREs). ROC curves showed similar predictive ability for MACE for 2MACE and TIMI-AF, in both the ATHERO-AF (0.698 vs. 0.688, respectively P=0.783) and AMADEUS (0.657 vs. 0.569, respectively P=0.057) cohorts. Similarly, the TIMI-AF showed a comparable c-index with 2MACE for NCOs...... in the ATHERO-AF (0.676 vs. 0.667, P=0.737), and AMADEUS (0.666 vs. 0.663, P=0.859) cohorts. No differences were found between the 2 scores for the prediction of CREs (0.675 vs. 0.684, P=0.740 in ATHERO-AF and 0.669 vs. 0.667, P=0.889 in AMADEUS for 2MACE and TIMI-AF, respectively). CONCLUSIONS: This study...

  1. Exploration of the possible effect on survival of lead-time associated with implementation of cancer patient pathways among symptomatic first-time cancer patients in Denmark

    DEFF Research Database (Denmark)

    Jensen, Henry; Vedsted, Peter

    2017-01-01

    Implementeringen af standardiserede kræftpakkeforløb har medført hurtigere udredning og behandling af kræftpatienter, og kræftoverlevelsen rapporteres samtidig at være forbedret. Overlevelsen kan dog være forbedret på falsk baggrund, da diagnosen – som en følge af kræftpakkerne – stilles tidliger...

  2. Safety and Efficacy of Rivaroxaban in Patients With Cardiac Implantable Electronic Devices: Observations From the ROCKET AF Trial.

    Science.gov (United States)

    Leef, George C; Hellkamp, Anne S; Patel, Manesh R; Becker, Richard C; Berkowitz, Scott D; Breithardt, Günter; Halperin, Jonathan L; Hankey, Graeme J; Hacke, Werner; Nessel, Christopher C; Singer, Daniel E; Fox, Keith A A; Mahaffey, Kenneth W; Piccini, Jonathan P

    2017-06-14

    Although implantation of cardiac implantable electronic devices (CIEDs) in patients receiving warfarin is well studied, limited data are available on the use of oral factor Xa inhibitors in this setting. Using data from Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) (n=14 264), we compared baseline characteristics and clinical outcomes in patients with atrial fibrillation randomized to rivaroxaban versus warfarin who did and did not undergo CIED implantation or revision. In this post-hoc, postrandomization, on-treatment analysis, only the first intervention per patient was analyzed. During a median follow-up of 2.2 years, 453 patients (242 rivaroxaban group; 211 warfarin group) underwent de novo CIED implantation (64.2%) or revision procedures (35.8%). Patients who received CIEDs were older, more likely to be male, and more likely to have past myocardial infarction, but had similar stroke risk compared to patients who did not receive CIEDs. Most patients who received a device had study drug interrupted for the procedure and did not receive bridging anticoagulation. During the 30-day postprocedural period, 11 patients (4.55%) in the rivaroxaban group experienced bleeding complications compared with 15 (7.13%) in the warfarin group. Thromboembolic complications occurred in 3 patients (1.26%) in the rivaroxaban group and 1 (0.48%) in the warfarin group. Event rates were too low for formal hypothesis testing. Bleeding and thromboembolic events were low in both rivaroxaban- and warfarin-treated patients. Periprocedural use of oral factor Xa inhibitors in CIED implantation requires further study in prospective, randomized trials. URL: http://www.clinicaltrials.gov. Unique identifier: NCT00403767. © 2017 The Authors, Bayer US LLC, and Janssen Research and Development. Published on behalf of the American Heart Association, Inc., by Wiley.

  3. Restaurering af Skjern Å

    DEFF Research Database (Denmark)

    Jessen, K.; Boysen Larsen, B.; Bundgaard, P.

    Denne rapport indeholder resultaterne af den natur- og miljøovervågning, der blev iværksat som en del af naturgenopretningen af Skjern Å 1999-2002. Ved projektet ophørte den kunstige afvanding af den vestlige del af Skjern Å dalen. Størstedelen af de dyrkede arealer ændredes til ekstensive græsni...

  4. Avancering af maksillen ved brug af osseodistraktion

    DEFF Research Database (Denmark)

    Andersen, Kristian; Svenstrup, M; Nørholt, Sven Erik

    2010-01-01

    . Gennemgangen omfatter emnerne: 1) stabilitet og recidiv, 2) peroperativ og postoperativ morbiditet samt gener, 3) ændringer af blødtvæv under distraktion, 4) ændringer af velopharynx og taleevne samt 5) psykosociale effekter af behandlingen. Resultater – De eksisterende artikler har samlet set generelle...

  5. Efficacy and safety of rivaroxaban compared with warfarin in patients with peripheral artery disease and non-valvular atrial fibrillation: insights from ROCKET AF.

    Science.gov (United States)

    Jones, William Schuyler; Hellkamp, Anne S; Halperin, Jonathan; Piccini, Jonathan P; Breithardt, Gunter; Singer, Daniel E; Fox, Keith A A; Hankey, Graeme J; Mahaffey, Kenneth W; Califf, Robert M; Patel, Manesh R

    2014-01-01

    Vascular disease is included in a risk scoring system to predict stroke in patients with non-valvular atrial fibrillation (AF). This post hoc analysis of ROCKET AF aimed to determine the absolute rates of stroke and bleeding, and the relative effectiveness and safety of rivaroxaban vs. warfarin in patients with and without peripheral artery disease (PAD). Peripheral artery disease was defined on the case-report form as the presences of intermittent claudication, amputation for arterial insufficiency, vascular reconstruction, bypass surgery, or percutaneous intervention to the extremities, or previously documented abdominal aortic aneurysm. ROCKET AF was a double-blind, double-dummy, randomized-controlled trial comparing rivaroxaban and warfarin for the prevention of stroke or systemic embolism. A total of 839 (5.9%) patients in ROCKET AF had PAD. Patients with and without PAD had similar rates of stroke or systemic embolism [HR: 1.04, 95% CI (0.72, 1.50), P = 0.84] and major or non-major clinically relevant (NMCR) bleeding [HR: 1.11, 95% CI (0.96, 1.28), P = 0.17], respectively. The efficacy of rivaroxaban when compared with warfarin for the prevention of stroke or systemic embolism was similar in patients with PAD (HR: 1.19, 95% CI: 0.63-2.22) and without PAD (HR: 0.86, 95% CI: 0.73-1.02; interaction P = 0.34). There was a significant interaction for major or NMCR bleeding in patients with PAD treated with rivaroxaban compared with warfarin (HR: 1.40, 95% CI: 1.06-1.86) compared with those without PAD (HR: 1.03, 95% CI: 0.95-1.11; interaction P = 0.037). Patients with PAD in ROCKET AF did not have a statistically significant higher risk of stroke or systemic embolism than patients without PAD, and there were similar efficacy outcomes in patients treated with rivaroxaban and warfarin. In PAD patients, there was a higher risk of major bleeding or NMCR bleeding with rivaroxaban when compared with warfarin (interaction P = 0.037). Further investigation is warranted to

  6. Intermittent vs. Continuous Anticoagulation theRapy in patiEnts with Atrial Fibrillation (iCARE-AF): a randomized pilot study.

    Science.gov (United States)

    Stavrakis, Stavros; Stoner, Julie A; Kardokus, Joel; Garabelli, Paul J; Po, Sunny S; Lazzara, Ralph

    2017-01-01

    We hypothesized that intermittent anticoagulation based on daily rhythm monitoring using the novel oral anticoagulants (NOACs) is feasible and safe among patients with paroxysmal atrial fibrillation (AF). Patients with paroxysmal AF and ≥1 risk factors for stroke were randomized to either intermittent or continuous anticoagulation. Those in the intermittent group were instructed to transmit a daily ECG using an iPhone-based rhythm monitoring device. If AF was detected, patients received one of the NOACs for 48 h-1 week. Patients who failed to transmit an ECG for three consecutive days or more than 7 days total were crossed over to continuous anticoagulation. Patients in the continuous group received one of the NOACs. Fifty-eight patients were randomized to either intermittent (n = 29) or continuous anticoagulation (n = 29). Over a median follow-up of 20 months, 20 patients in the intermittent group failed to submit a daily ECG at least once (median three failed submissions). Four patients (14 %) crossed over to continuous anticoagulation due to failure to submit an ECG for three consecutive days. One stroke (continuous group) occurred during the study. Major bleeding occurred in two patients in the continuous and one patient in the intermittent group, after crossing over to continuous anticoagulation. In a prespecified per-protocol analysis, gastrointestinal bleeding was more frequent in the continuous group (16 vs. 0 %; p = 0.047). Intermittent anticoagulation based on daily rhythm monitoring is feasible and may decrease bleeding in low-risk patients with paroxysmal AF. A larger trial, adequately powered to detect clinical outcomes, is warranted.

  7. Status of oral anticoagulant treatment in patients with nonvalvular atrial fibrillation in Spain. REACT-AF Study.

    Science.gov (United States)

    de Andrés-Nogales, F; Oyagüez, I; Betegón-Nicolás, L; Canal-Fontcuberta, C; Soto-Álvarez, J

    2015-03-01

    Oral anticoagulant therapy is complex due to the need for control and the hemorrhagic risk the therapy entails. This study aims to determine the standard clinical practice in the treatment for preventing stroke in patients with nonvalvular atrial fibrillation (NVAF) in Spain. The Real Evidence of Anti Coagulation Treatment in AF is a European, multicenter, multinational, observational, retrospectively monitored cohort of patients with NVAF. This study included patients recruited in Spain with at least one visit during the period of inclusion (May 2010/April 2012). The study evaluated the following: a) persistence of oral anticoagulant treatment (time to discontinuation); b) persistence rate (% of patients in treatment) at 6, 12 and 24 months and at 5 years; c) therapeutic compliance (medication possession ratio); d) the correlation between the treatment followed and that recommended by the European Society of Cardiology; and the incidence of stroke and hemorrhagic events. The patients treated with oral anticoagulants (n=7,526) had a median time to discontinuation of treatment of 1.99 years and a persistence rate at 5 years of 26% (discontinuation ≥3 months). The compliance (mean MPR) was 0.54±0.36. The incidence of stroke was 0.3/100 person-years, and the incidence of hemorrhagic events was 2.4/100 person-years. Fifty-eight percent of the patients with NVAF (n=12,514) followed the recommendations of the European Society of Cardiology. Forty-two percent of the patients with NVAF did not follow the recommendations of the European Society of Cardiology. We detected low persistence and treatment compliance rates for oral anticoagulants. Copyright © 2014 Elsevier España, S.L.U. All rights reserved.

  8. Efficacy and safety of rivaroxaban versus warfarin in patients from mainland China with nonvalvular atrial fibrillation: A subgroup analysis from the ROCKET AF trial.

    Science.gov (United States)

    Sun, Yihong; Hu, Dayi; Stevens, Susanna; Lokhnygina, Yuliya; Becker, Richard C; Berkowitz, Scott D; Breithardt, Günter; Hacke, Werner; Halperin, Jonathan L; Hankey, Graeme J; Mahaffey, Kenneth W; Nessel, Christopher C; Piccini, Jonathan P; Singer, Daniel E; Fox, Keith A A; Patel, Manesh R

    2017-08-01

    The ROCKET AF study evaluated once-daily rivaroxaban versus dose-adjusted warfarin for the prevention of stroke and systemic embolism in patients with atrial fibrillation (AF). In this analysis, we compared rivaroxaban with warfarin in patients with AF from China, East Asia, and the rest of the world (ROW). We assessed baseline demographics and interaction of treatment effects of rivaroxaban versus warfarin among patients from mainland China, other East Asian countries, and ROW. Of the 14,236 patients enrolled in the per-protocol population, 495 were from mainland China, 433 from other East-Asian regions, and 13,308 from the rest of the world (ROW). At baseline, patients from China had significantly higher rates of previous stroke/transient ischemic attack (TIA) compared with patients from other East Asian regions and ROW (79.6%, 44.6%, 51.6% respectively; p0.12). Numerically higher rates of intracranial bleeding were seen in patients from China receiving warfarin versus rivaroxaban. In patients from China, rates of intracranial hemorrhage were numerically lower among those receiving rivaroxaban and consistent with the overall trial. URL: https://www.clinicaltrials.gov/. Unique identifier: NCT00403767. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. Præsentation af symptomer i almen praksis hos patienter med cancer

    DEFF Research Database (Denmark)

    Nielsen, Tine Nørgaard; Hansen, Rikke Pilegaard; Vedsted, Peter

    2010-01-01

    and prostate cancer presented diagnosis-specific symptoms (change in bowel habits, cough and bladder dysfunction) as well as more non-specific symptoms (pain, weight loss and fatigue). The GPs interpreted the symptoms as alarm symptoms in 49%, as general symptoms in 24% and as non-cancer specific symptoms...... was 3,208 corresponding to 1.7 reported symptoms per patient. The majority (57.6%) of patients presented only one symptom. Symptoms varied with the type of cancer. Patients with breast cancer and malignant melanoma mainly presented with diagnosis-specific symptoms. Patients with colorectal, lung......INTRODUCTION: For the majority of cancer patients, the diagnostic investigations begin in general practice. The aim of the study was to investigate for which symptoms cancer patients consulted their general practitioner (GP). MATERIAL AND METHODS: All newly diagnosed cancer patients and their GPs...

  10. Visitation af patienter, som indlægges akut på mistanke om hjertesygdom

    DEFF Research Database (Denmark)

    Okkels Jensen, Lisette; Holmvang, Lene; Forberg, Jakob Lundager

    2013-01-01

    Overall, the future emergency departments in Denmark serve as a single portal of entry for all acute patients. At the same time an expansion of prehospital diagnosing and triage will take place. In patients suspected of life-threatening cardiac conditions with specialized treatment requirements...... where the time factor is important, the prehospital triage will be important to identify patients who should be transferred directly to a cardiac care unit to reduce prehospital and in-hospital delays of treatment....

  11. Effekten af cellebehandling hos patienter med kronisk iskæmisk hjertesygdom

    DEFF Research Database (Denmark)

    Mathiasen, Anders Bruun; Ali Qayyum, Abbas; Kastrup, Jens

    2015-01-01

    The present Cochrane review included 23 studies randomized placebo-controlled clinical trials with a total of 1,255 patients. The effect of autologous cell therapy versus placebo was examined on left ventricular ejection fraction (LVEF), adverse effects and mortality in patients with chronic isch...

  12. PET/CT i opfølgningen af patienter opereret for kolorektalcancer

    DEFF Research Database (Denmark)

    Hansen, Anne Fogh; Jensen, Mads Radmer; Nordholm-Carstensen, Andreas

    2016-01-01

    ) on visualizing relapse in patients with CRC after curative surgery. Therefore, PET/CT could probably be valuable in patients with unexplained increase in carcinoembryonic antigen level or a clinical suspicion of relapse, but PET/CT is not recommended as a standard in follow-up after CRC....

  13. Psykoterapeutisk dagbehandling af svaert personlighedsforstyrrede patienter. En toårsopgørelse

    DEFF Research Database (Denmark)

    Christensen, Nils Balle; Toft, John; Petersen, Brian

    2007-01-01

    INTRODUCTION: A psychotherapeutic day treatment (DT) for patients with severe personality disorders (PD) was established in January 2003, consisting of five months of intensive psychodynamic based integrated therapy for 14 patients. This paper presents results from the first two years. MATERIAL A...

  14. Sikkerhed af magnetisk resonans-skanning hos patienter med pacemaker og implanterbar defibrillator

    DEFF Research Database (Denmark)

    Al-Sabagh, Kifah Hekmat; Christensen, Britta Ege; Thøgersen, Anna Margrethe

    2010-01-01

    INTRODUCTION: The presence of a cardiac implantable device is ICD considered an absolute contraindication to magnetic resonance imaging (MRI). The purpose of this study was to evaluate the safety of performing MRI in patients with cardiac pacemakers and ICDs that had a compelling clinical need...... for MRI examination. MATERIAL AND METHODS: During a period of nine years we have included 65 patients with cardiac devices (60 pacemakers and five ICDs) who underwent a total of 73 MRI examinations at 1.5 T. All pacemakers were reprogrammed before MRI to asynchronous mode to avoid MRI-induced inhibition...... safely in 63 patients. Inhibition of pacemaker output was observed in one patient and induction of ventricular fibrillation was observed in another with ICD. A significant increase in PCT was rare and only detected in 1% of all electrodes. CONCLUSION: MRI can be performed safely in patients...

  15. Energirenovering af Traneparken

    DEFF Research Database (Denmark)

    Rose, Jørgen; Thomsen, Kirsten Engelund; Mørck, Ove

    Nærværende rapport udgør en del af afrapporteringen af PSO ELFORSK projektet Vejledning for energirenovering af boligblokke til lavenergiklasse 2015 og 2020. Arbejdet har været finansieret af PSO midler via ELFORSK, projekt: 347-023. Formålet med projektet er at udvikle en vejledning for dybtgående...

  16. Undervisning af tosprogede elever

    DEFF Research Database (Denmark)

    Horst, Christian

    2003-01-01

    Artiklen fremdrager hovedresultaterne fra Virginia P. Collier's og Wayne P. Thomas's længdeundersøgelser af tosprogede elever i USA, som formentlig er de mest omfattende undersøgelser af undervisningen af tosprogede elever overhovedet. Resultaterne diskuteres i relation til udviklingen af en...

  17. Om distributionen af hvidhed

    DEFF Research Database (Denmark)

    Frello, Birgitta

    2007-01-01

    Med udgangspunkt i John Fords Western, Forfølgeren fra 1956, præsenteres en analyse af repræsentationer af race og overskridelse af raceskel, særligt i relation til konstitueringen af subjektpositioner, hvorfra spørgsmål om hvidhed og ikke-hvidhed kan afgøres....

  18. Lyden-af-Leg

    DEFF Research Database (Denmark)

    Toft, Herdis

    Præsentation af seniorforsker-projekt Lyden-af-Leg i et traderingsperspektiv og med indledende fokus på YouTube som traderings-platform.......Præsentation af seniorforsker-projekt Lyden-af-Leg i et traderingsperspektiv og med indledende fokus på YouTube som traderings-platform....

  19. Intrauterin insemination med donorsaed. Behandling af ufrivillig barnløshed på grund af mandlig infertilitet

    DEFF Research Database (Denmark)

    Vilsbøll, Tina; Helmsøe-Zinck, Lise; Andersen, A N

    1994-01-01

    Intrauterine insemination with cryopreserved donor semen was performed in 114 women in a total of menstrual 381 cycles during the period 1.2.1991 to 15.5.1993. Eighty-one pregnancies were recorded corresponding to a conception rate of 21% per insemination cycle. After ten cycles the probability...... of conception and expected delivery was respectively 96% and 86%. The results show that intrauterine insemination with donor semen is a good treatment for couples with male infertility. Ultrasonic measurement of the follicles and timing of hCG injection were used for optimal timing of intrauterine donor...... insemination. The quality of the semen used for insemination is important. It is recommended to inseminate with at least two million of spermatozoa where at least 20% have normal motility....

  20. Individualisering af behandling af osteoartikulære infektioner hos børn kan afkorte behandlingsforløbet

    DEFF Research Database (Denmark)

    Kristensen, Kim; Andersen, Jesper; Hansen, Kjeld Gade

    2014-01-01

    Older studies have suggested that antibiotic treatment for less than 21 days in children with osteoarticular infections is associated with relapse, and therefore traditionally these infections have been treated for six weeks with an intravenous phase of one week. However, four new prospective...... studies suggest that if the duration of treatment is individualized and made dependent on the clinical response and the C-reactive protein level, the treatment course may be shortened substantially without increasing the risk of relapse or sequelae. This article reviews older and newer literature...

  1. Behandling af våd aldersrelateret makuladegeneration med vaskulaer endotel vaekstfaktorhaemmer. Gennemgang af et Cochrane-review

    DEFF Research Database (Denmark)

    Bloch, Sara Brandi; Larsen, Michael

    2009-01-01

    This evaluation of a Cochrane-review including five clinical trials of good methodological quality indicates that the antiangiogenic therapeutic agents, pegaptanib and ranibizumab, are effective treatment strategies for neovascular Age-Related Macular Degeneration (AMD). The review does not include...

  2. Effekten af Ginkgo biloba-ekstrakt hos patienter med claudicatio intermittens

    DEFF Research Database (Denmark)

    Drabaek, H; Petersen, J R; Wïnberg, N

    1996-01-01

    Eighteen patients with stable intermittent claudication were randomized in a double blind cross-over study comparing the effects of the Ginkgo biloba extract GB-8 at a dose of 120 mg o.d. with placebo. All patients were treated for three months with the active extract and three months with placebo...... and the inability to remember were both reduced, when comparing results during active treatment to placebo. Short-term memory did not change significantly. In conclusion, our study has shown that treatment with the Ginkgo biloba extract GB-8 improves some cognitive functions in elderly patients with moderate...

  3. Forudsaetninger for udenlandske laegers kliniske arbejde--vurderet af dansk sundhedspersonale, patienter og udenlandske laeger

    DEFF Research Database (Denmark)

    Mitchell, A.U.; Tabaei, F.H.; Ostergaard, D.

    2008-01-01

    was adequate, but nurses thought otherwise. A large majority of Danish personnel (78-89%) had experienced that they themselves or patients could not understand a foreign doctor. A lesser number of foreign doctors (27-33%) had the same experience with Danish personnel or patients. Foreign doctors' language...... and their cultural backgrounds was sent to foreign doctors, to Danish doctors, to Danish nurses, and to patients in Greater Copenhagen. A total of 1539 questionnaires were sent. RESULTS: 49-57% in each group replied. The majority of both foreign doctors and Danish doctors found that introductory guidance...... are not so highly esteemed. 90% of patients are of the opinion that foreign doctors are professionally competent. Cultural background can influence clinical practice in the opinion of 50% of Danish personnel and 42% of foreign doctors. CONCLUSION: Insufficient communication is the biggest challenge...

  4. An Open-label, Single-dose, Pharmacokinetic Study of Factor VIII Activity After Administration of Moroctocog Alfa (AF-CC) in Male Chinese Patients With Hemophilia A.

    Science.gov (United States)

    Liu, Hongzhong; Wu, Runhui; Hu, Pei; Sun, Feifei; Xu, Lihong; Liang, Yali; Nepal, Sunil; Qu, Peng Roger; Huard, Francois; Korth-Bradley, Joan M

    2017-07-01

    Hemophilia A represents up to 80% of all hemophilia cases in China. In patients with this condition, bleeding can be prevented and controlled by administering clotting factor VIII (FVIII). Since their initial availability, recombinant FVIII products have undergone several iterations to enhance their safety. Moroctocog alfa albumin-free cell culture (AF-CC) is among the third generation of recombinant FVIII products and received regulatory approval in China in August 2012. The present study characterizes the single-dose pharmacokinetic parameters of FVIII activity (FVIII:C) after administration of moroctocog alfa (AF-CC) in male Chinese patients with hemophilia A. This multicenter, open-label, single-dose study enrolled 13 male Chinese patients diagnosed with severe hemophilia A (FVIII:C hemophilia A. The pharmacokinetic profile in older patients was similar to that previously reported with recombinant FVIII products in studies with a predominantly white population; younger patients had reduced exposure to FVIII:C. The single doses of moroctocog alfa (AF-CC) were well tolerated; 2 cases of transient, low-titer FVIII inhibitor development were observed. ClinicalTrials.gov identifier: NCT02461992. Copyright © 2017 Elsevier HS Journals, Inc. All rights reserved.

  5. Øget forekomst af depression hos patienter med hepatitis C-infektion

    DEFF Research Database (Denmark)

    Hjerrild, Simon; Renvillard, Signe Groth; Leutscher, Peter Derek Christian

    2010-01-01

    neuroinfection. Evidence to support that former intravenous drug abuse increases the risk of depression is lacking. It is particularly important to diagnose and treat depression in HCV patients as it constitutes a relative contraindication to antiviral treatment and may jeopardize therapeutic outcome.......The prevalence of depression is increased in patients with chronic hepatitis C virus (HCV) infection. Several aetiological mechanisms are thought to be involved, e.g. premorbid psychiatric disease, genetic disposition to affective disorders, socio-economic factors, stigmatization and possibly HCV...

  6. Sikkerhed af magnetisk resonans-skanning hos patienter med pacemaker og implanterbar defibrillator

    DEFF Research Database (Denmark)

    Al-Sabagh, Kifah Hekmat; Christensen, Britta Ege; Thøgersen, Anna Margrethe

    2010-01-01

    INTRODUCTION: The presence of a cardiac implantable device is ICD considered an absolute contraindication to magnetic resonance imaging (MRI). The purpose of this study was to evaluate the safety of performing MRI in patients with cardiac pacemakers and ICDs that had a compelling clinical need fo...

  7. Sikkerhed af magnetisk resonans-skanning hos patienter med pacemaker og implanterbar defibrillator

    DEFF Research Database (Denmark)

    Al-Sabagh, Kifah Hekmat; Christensen, Britta Ege; Thøgersen, Anna Margrethe

    2010-01-01

    The presence of a cardiac implantable device is ICD considered an absolute contraindication to magnetic resonance imaging (MRI). The purpose of this study was to evaluate the safety of performing MRI in patients with cardiac pacemakers and ICDs that had a compelling clinical need for MRI examinat...

  8. Forebyggelse af skeletrelaterede hændelser hos patienter med knoglemetastaser ved solide tumorer

    DEFF Research Database (Denmark)

    Kamby, Claus; Tarp, Simon; Mellemgaard, Anders

    2014-01-01

    This article is based on a systematic literature search and meta-analyses of clinical data regarding effects of bisphosphonates (BP) and denosumab (DS) on preventing skeletal related events (SRE) in patients with bone metastases from solid tumours. Although there are pharmacological differences b...

  9. Patient med myelomatose med infiltrat på røntgen af thorax

    DEFF Research Database (Denmark)

    Schoos, Ann-Marie Malby; Steentoft, Johnna; Petersen, Michael Mørk

    2010-01-01

    A 71-year-old man was referred to the lung department with pain in the right side of the chest through three months, especially when physically active. The patient presented with a tendency to shortness of breath, fatigue, low energy level and night sweats. The tentative diagnosis of pleural tumo...

  10. Rehabilitering og palliation af patienter med svær KOL bør integreres

    DEFF Research Database (Denmark)

    Ringbæk, Thomas; Wilcke, Jon Torgny Rostrup

    2013-01-01

    Treatment elements of rehabilitation and palliative care are described in relation to the main clinical manifestations of severe and very severe chronic obstructive pulmonary disease (COPD). With increasing loss of function the need for multidisciplinary effort increases. Physiotherapy...... especially for patients with frequent exacerbations....

  11. Telemedicinsk praehospital diagnostik og visitation af en patient med akut lungeemboli

    DEFF Research Database (Denmark)

    Terkelsen, Astrid J.; Nielsen-Kudsk, Jens Erik; Andersen, Henning Rud

    2008-01-01

    Mortality in untreated pulmonary embolism is high and short-term outcome depends on a timely diagnosis. In this case telemedicine involving 12-lead ECG and GSM-based communication between the patient in the ambulance and the telemedical staff resulted in remote pre-hospital suspicion of acute...

  12. 50-års-registerefterundersøgelse af 112 patienter med klassisk neurosediagnose

    DEFF Research Database (Denmark)

    Jepsen, Peter Winning; Juel, Knud; Bech, Per

    2007-01-01

    INTRODUCTION: The study is a register follow-up on a group of patients with a diagnosis of neurosis according to the Danish psychiatric/psychoanalytical tradition. The study group consists of the 'hospital material' used by the late Erling Jacobsen, M.D., in his doctoral thesis of 1965. MATERIALS...

  13. Immunmodulerende effekt af LongoVital hos patienter med recidiverende aftøs stomatit. 2

    DEFF Research Database (Denmark)

    Pedersen, A; Klausen, B; Hougen, H P

    1991-01-01

    LongoVital (LV) (DK. reg. no. 5178/75) is a herbal-based tablet enriched with recommended doses of vitamins. Peripheral lymphocyte subsets: T-helper/CD4 (OKT4+) and T-suppressor/cytotoxic/CD8 (OKT8+) were studied quantitatively in 31 otherwise healthy patients with minor recurrent aphthous...

  14. Effekten af Ginkgo biloba-ekstrakt hos patienter med claudicatio intermittens

    DEFF Research Database (Denmark)

    Drabaek, H; Petersen, J R; Wïnberg, N

    1996-01-01

    and the inability to remember were both reduced, when comparing results during active treatment to placebo. Short-term memory did not change significantly. In conclusion, our study has shown that treatment with the Ginkgo biloba extract GB-8 improves some cognitive functions in elderly patients with moderate...

  15. Net clinical benefit of rivaroxaban versus warfarin in Japanese patients with nonvalvular atrial fibrillation: a subgroup analysis of J-ROCKET AF.

    Science.gov (United States)

    Uchiyama, Shinichiro; Hori, Masatsugu; Matsumoto, Masayasu; Tanahashi, Norio; Momomura, Shin-Ichi; Goto, Shinya; Izumi, Tohru; Koretsune, Yukihiro; Kajikawa, Mariko; Kato, Masaharu; Ueda, Hitoshi; Iekushi, Kazuma; Yamanaka, Satoshi; Tajiri, Masahiro

    2014-01-01

    The risk factors that have been identified for bleeding events with rivaroxaban are predominantly the same as those predicting thromboembolic ones in patients with atrial fibrillation (AF). Our aim was to determine the net clinical benefit (NCB) from the results of the J-ROCKET AF trial, in which rivaroxaban was compared with warfarin in Japanese patients with AF. Two strategies were adopted to quantify the NCB. First, the NCB was calculated as the number of ischemic strokes avoided with anticoagulation minus the number of excess intracranial hemorrhage (ICH) with a weight of 1.5. Second, the composite end point of major bleeding events and secondary efficacy end points (stroke, noncentral nervous system systemic embolism, myocardial infarction and death) to ascertain the NCB were established. Subgroup analysis by CHADS2 score or creatinine clearance was also performed. The adjusted NCB, which was given a weight of 1.5 for ICH, was nominally significant in favor of rivaroxaban therapy (difference in incidence rate -2.13; 95% confidence interval [CI]: -.26 to -3.99). Furthermore, the event rate of the composite end point tended to be lower in patients treated with rivaroxaban than in those treated with warfarin (rivaroxaban: 4.97% per year, warfarin: 6.11% per year; difference in incidence rate: -1.14; 95% CI: -3.40 to 1.12). The event rate of the composite end point tended to be consistently low in patients treated with rivaroxaban in the subanalysis by CHADS2 score and renal function. Analysis of the NCB supports that rivaroxaban therapy provides clinical benefit for Japanese patients with AF. Copyright © 2014 National Stroke Association. Published by Elsevier Inc. All rights reserved.

  16. Clinical outcomes of AF patients treated with the first and second-generation of circular mapping and ablation catheter: insights from a real world multicenter experience.

    Science.gov (United States)

    Rovaris, Giovanni; De Filippo, Paolo; Laurenzi, Francesco; Zanotto, Gabriele; Bottoni, Nicola; Pozzi, Mattia; Giofrè, Fabrizio; De Girolamo, Piergiuseppe; Visentin, Emanuela; Piazzi, Elena; Ferrari, Paola

    2017-12-01

    Complete pulmonary vein isolation (PVI) is the best documented target for catheter ablation, and different technologies have shown comparable outcomes. The multielectrode phased-RF/duty cycled (PhRF/DC) pulmonary vein ablation catheter (PVAC) and its second generation (PVAC-GOLD) have shown promising clinical results in single and multicenter experiences. Our aim is to assess and compare the safety and efficacy in the real clinical practice among two generations of circular PhRF/DC catheters by performing PVI in patients suffering from recurrent atrial fibrillation (AF). Eighty-four AF patients treated with PVAC and 64 with PVAC-GOLD were prospectively followed in five Italian cardiology centers in the mainframe of the 1STOP-ClinicalService project. Fluoroscopic and total procedure time were significantly different in the two groups. In particular, in the PVAC-GOLD group, the mean fluoroscopic time was 22.8 ± 12.7 min vs 31.6 ± 18.9 in the PVAC group (p = 0.002), and the mean total procedure duration was 117.6 ± 36.0 vs 147.4 ± 40.6, in the PVAC-GOLD group and the PVAC group, respectively (p = 0.001). Only two out of 148 patients reported a peri-procedural complication. Over 20.9 ± 12.0 months of follow-up, AF recurrence occurred in 58 patients. Kaplan-Meier freedom from AF recurrence did not differ between the two groups (64.1 ± 10% in the PVAC group vs 68.2 ± 9% in the PVAC-GOLD group at 1 year, p = ns). In our multicenter analysis, AF ablation using two generations of circular PhRF/DC catheters is safe and effective. No difference was observed in terms of safety and efficacy of the AF ablation between the two catheters, with the mean procedural time being shorter in the PVAC-GOLD group.

  17. Antisecretory factor (AF) exerts no effects on intracranial pressure (ICP) waves and ICP in patients with idiopathic normal pressure hydrocephalus and idiopathic intracranial hypertension.

    Science.gov (United States)

    Eide, Per Kristian; Eidsvaag, Vigdis Andersen; Hansson, Hans-Arne

    2014-08-15

    Antisecretory factor (AF) and derivates thereof counteract brain edema and inflammation, and normalize ICP dynamics. The aim of the present study was to assess whether AF normalized the abnormal ICP waves, indicative of impaired intracranial compliance, seen in patients with idiopathic normal pressure hydrocephalus (iNPH) and idiopathic intracranial hypertension (IIH). The hypothesis was that brain swelling contributes to the abnormal ICP waves. The study enrolled patients undergoing diagnostic ICP wave monitoring for either iNPH or IIH. The ICP waves and ICP were recorded continuously before and after oral administration of Salovum® (0.5 g/kg body weight/day divided by three doses), a freeze-dried egg yolk enriched in AF activity. Mean ICP wave amplitude (MWA), mean ICP wave rise time coefficient (MWRTC), and mean ICP were compared before and after Salovum® administration. A total of 10 iNPH patients and 8 IIH patients were included. No significant changes in the ICP wave indices or ICP were seen after Salovum® administration. Neither any significant time-dependent effect was observed. The lack of effect of Salovum® on ICP wave indices and ICP in iNPH and IIH may provide indirect evidence that brain swelling does not play a crucial role in the ICP wave indices or ICP of these conditions. Copyright © 2014 Elsevier B.V. All rights reserved.

  18. Effekten af Ginkgo biloba-ekstrakt hos patienter med claudicatio intermittens

    DEFF Research Database (Denmark)

    Drabaek, H; Petersen, J R; Wïnberg, N

    1996-01-01

    Eighteen patients with stable intermittent claudication were randomized in a double blind cross-over study comparing the effects of the Ginkgo biloba extract GB-8 at a dose of 120 mg o.d. with placebo. All patients were treated for three months with the active extract and three months with placebo....... The effects of treatment on arterial insufficiency were quantified by measurements of systemic and peripheral systolic blood pressures, and pain-free and maximal walking distances on a tread-mill. Questionnaires based on visual analogue scales were used to quantify the severity of leg pain, impairment...... of concentration, and inability to remember. Short-term memory was objectively assessed. We did not find any significant changes in either peripheral blood pressures, walking distances or the severity of leg pain. Systemic blood pressure was reduced both by placebo and GB-8. The impairment of concentration...

  19. Forudsaetninger for udenlandske laegers kliniske arbejde--vurderet af dansk sundhedspersonale, patienter og udenlandske laeger

    DEFF Research Database (Denmark)

    Mitchell, A.U.; Tabaei, F.H.; Ostergaard, D.

    2008-01-01

    INTRODUCTION: Many foreign doctors work in Danish hospitals. This study concerns the opportunities available to and difficulties encountered by these doctors. MATERIALS AND METHODS: A questionnaire concerning guidance available to foreign doctors, their linguistic and professional competence and ...... for foreign doctors, and can influence the evaluation of their professional competence. Cultural differences may influence foreign doctors' cooperation with Danish personnel. Patients are satisfied with treatment given by foreign doctors Udgivelsesdato: 2008/5/19......INTRODUCTION: Many foreign doctors work in Danish hospitals. This study concerns the opportunities available to and difficulties encountered by these doctors. MATERIALS AND METHODS: A questionnaire concerning guidance available to foreign doctors, their linguistic and professional competence...... difficulties gave rise to feelings of insecurity and doubts about professional competence in both Danish personnel and patients (53-69%). Danish personnel estimate that European Union (EU) doctors' professional competence is equal to Danish doctors' professional competence, while non-EU foreign doctors...

  20. Forudsaetninger for udenlandske laegers kliniske arbejde--vurderet af dansk sundhedspersonale, patienter og udenlandske laeger

    DEFF Research Database (Denmark)

    Mitchell, A.U.; Tabaei, F.H.; Ostergaard, D.

    2008-01-01

    are not so highly esteemed. 90% of patients are of the opinion that foreign doctors are professionally competent. Cultural background can influence clinical practice in the opinion of 50% of Danish personnel and 42% of foreign doctors. CONCLUSION: Insufficient communication is the biggest challenge......INTRODUCTION: Many foreign doctors work in Danish hospitals. This study concerns the opportunities available to and difficulties encountered by these doctors. MATERIALS AND METHODS: A questionnaire concerning guidance available to foreign doctors, their linguistic and professional competence...... and their cultural backgrounds was sent to foreign doctors, to Danish doctors, to Danish nurses, and to patients in Greater Copenhagen. A total of 1539 questionnaires were sent. RESULTS: 49-57% in each group replied. The majority of both foreign doctors and Danish doctors found that introductory guidance...

  1. Vellykket behandling af supraventrikulær takykardi med modificeret Valsalvas manøvre

    DEFF Research Database (Denmark)

    Wallentin, Johan; Sjøl, Anette

    2016-01-01

    Supraventricular tachycardia (SVT) is a frequent challenge in medical emergency units. Adenosine, the drug of choice, may cause severe discomfort. The Danish Society of Cardiology's National Treatment Guidelines for SVT recommend first aid treatment with ''vagus stimulation such as carotid massage...

  2. Forebyggelse og behandling af fedme hos børn og unge

    DEFF Research Database (Denmark)

    Michaelsen, Kim Fleischer; Mølgaard, Christian; Richelsen, Bjørn

    2006-01-01

    In the last 10 years, there has been a marked increase in the prevalence of obesity in children beginning at 3-4 years of age. The only realistic solution to the problem is prevention. Although there is limited evidence for the effectiveness of preventive programmes, there is a consensus that mul......In the last 10 years, there has been a marked increase in the prevalence of obesity in children beginning at 3-4 years of age. The only realistic solution to the problem is prevention. Although there is limited evidence for the effectiveness of preventive programmes, there is a consensus...... that multisectorial action is urgently needed. This should include intervention at the family, school, municipal, regional and national levels, including the commercial sector and food companies. Treating childhood obesity has not been very successful, but some comprehensive community-based treatment programmes have...... shown reasonable long-term results. There is a need to establish such community-based treatments with emphasis on psychological aspects....

  3. Behandling med valproat under graviditet: beskrivelse af fire cases med føtalt valproatsyndrom

    DEFF Research Database (Denmark)

    Sabers, Anne; Larsen, Katja; Blichfeldt, Susanne

    2009-01-01

    INTRODUCTION: Treatment with valproate is associated with an increased risk of teratogenicity compared to other antiepileptic drugs and can cause a complex of serious symptoms usually referred to as "foetal valproate symdrome" which is characterised by major and minor malformations in association...... treated with valproate during pregnancy, were neuropediatrically and neuropsychologically examined in a non-acute setting. The mothers were screened for the 677C-T mutation. RESULTS: Four of seven examined children fulfilled the criteria for foetal valproate syndrome. Only one of the four mothers...... was heterozygote for the 677C-T mutation (CT, n = 1/4) and none of the mothers were homozygote (TT, n = 0/4) CONCLUSION: The foetal valproate syndrome is a complex of symptoms which is probably underdiagnosed and should be considered in the diagnostic evaluation program for children with developmental delay who...

  4. Ny viden om prognose for og behandling af børneabsenceepilepsi

    DEFF Research Database (Denmark)

    Bloch, Joakim; Miranda, Maria J

    2017-01-01

    Until now, ethosuximide (ESM), sodium valproate (VPA) and lamotrigine have been considered the drugs of choice in the management of childhood absence epilepsy, and there has been no high-validated evidence to distinguish their effects. New research shows, however, that while VPA and ESM are equally...

  5. Behandling med valproat under graviditet: beskrivelse af fire cases med føtalt valproatsyndrom

    DEFF Research Database (Denmark)

    Sabers, Anne; Larsen, Katja; Blichfeldt, Susanne

    2009-01-01

    treated with valproate during pregnancy, were neuropediatrically and neuropsychologically examined in a non-acute setting. The mothers were screened for the 677C-T mutation. RESULTS: Four of seven examined children fulfilled the criteria for foetal valproate syndrome. Only one of the four mothers......INTRODUCTION: Treatment with valproate is associated with an increased risk of teratogenicity compared to other antiepileptic drugs and can cause a complex of serious symptoms usually referred to as "foetal valproate symdrome" which is characterised by major and minor malformations in association...... was heterozygote for the 677C-T mutation (CT, n = 1/4) and none of the mothers were homozygote (TT, n = 0/4) CONCLUSION: The foetal valproate syndrome is a complex of symptoms which is probably underdiagnosed and should be considered in the diagnostic evaluation program for children with developmental delay who...

  6. Fæcestransplantation som behandling af Clostridium difficile-infektion, colitis ulcerosa og metabolisk syndrom

    DEFF Research Database (Denmark)

    Carstensen, Jeppe West; Hansen, Axel Kornerup

    2014-01-01

    Faecal transplantation as a treatment for Clostridium difficile infection, ulcerative colitis and the metabolic syndrome Faecal transplantation as a therapeutic tool is increasingly reported in the scientific literature. Faecal transplantation is currently becoming a treatment for nosocomial...

  7. Overlevelse efter lynnedslag og behandling af tilstødende komplikationer

    DEFF Research Database (Denmark)

    Pedersen, Malene Lægdsgaard; Uslu, Bülent; Lind, Morten Nikolaj

    2011-01-01

    Lightning strike is an unpredictable weather phenomenon which can cause a variety of injuries to the human body. We present a case report with a 24-year-old male football player, who survived prolonged cardiac arrest after a lighting strike and then presented with multiple organ dysfunction due t...

  8. Forskelle i behandling af børn med idiopatisk trombocytopenisk purpura

    DEFF Research Database (Denmark)

    Edslev, Pernille Wendtland; Kjærsgaard, Mimi; Rosthøj, Steen

    2010-01-01

    INTRODUCTION: Idiopathic thrombocytopenic purpura (ITP) is a rare immune-mediated bleeding disorder that usually takes a self-limiting and benign course. Due to the risk of intracranial haemorrhage, treatment regimens tend to be active. We present treatment data from 17 paediatric departments...

  9. Fæcestransplantation som behandling af Clostridium difficile-infektion, colitis ulcerosa og metabolisk syndrom

    DEFF Research Database (Denmark)

    Carstensen, Jeppe West; Hansen, Axel Kornerup

    2014-01-01

    Faecal transplantation as a treatment for Clostridium difficile infection, ulcerative colitis and the metabolic syndrome Faecal transplantation as a therapeutic tool is increasingly reported in the scientific literature. Faecal transplantation is currently becoming a treatment for nosocomial......, refractory infections with C. difficile. Furthermore, faecal transplantation has been suggested as a treatment for ulcerative colitis as well as for the metabolic syndrome. In the accumulated literature faecal transplantations appear to be safe, effective and superior to current treatments. Faecal...... transplantation remains a sparsely investigated treatment, however, especially for other diagnoses than C. difficile infection....

  10. Behandling af kardiogent shock med perkutan mekanisk cirkulationsstøtte

    DEFF Research Database (Denmark)

    Junker, Anders; Kaltoft, Anne Kjer; Hassager, Christian

    2013-01-01

    Despite rapid revascularisation with circulatory support using inotropes and intra-aortic balloon counterpulsation, the mortality of cardiogenic shock complicating acute myocardial infarction still exceeds 50%. An alternative treatment strategy is restoration of cardiac output by using a ventricu......Despite rapid revascularisation with circulatory support using inotropes and intra-aortic balloon counterpulsation, the mortality of cardiogenic shock complicating acute myocardial infarction still exceeds 50%. An alternative treatment strategy is restoration of cardiac output by using...... a ventricular assist device which can be inserted in the acute setting using the Impella device, a catheter-based flow pump. DanShock is a Danish multicentre study that will assess whether circulatory support using the Impella device will improve the outcome of cardiogenic shock compared to conventional...

  11. Forebyggelse og behandling af fedme hos børn og unge

    DEFF Research Database (Denmark)

    Michaelsen, Kim Fleischer; Mølgaard, Christian; Richelsen, Bjørn

    2006-01-01

    In the last 10 years, there has been a marked increase in the prevalence of obesity in children beginning at 3-4 years of age. The only realistic solution to the problem is prevention. Although there is limited evidence for the effectiveness of preventive programmes, there is a consensus that mul...... shown reasonable long-term results. There is a need to establish such community-based treatments with emphasis on psychological aspects.......In the last 10 years, there has been a marked increase in the prevalence of obesity in children beginning at 3-4 years of age. The only realistic solution to the problem is prevention. Although there is limited evidence for the effectiveness of preventive programmes, there is a consensus...... that multisectorial action is urgently needed. This should include intervention at the family, school, municipal, regional and national levels, including the commercial sector and food companies. Treating childhood obesity has not been very successful, but some comprehensive community-based treatment programmes have...

  12. Diagnose og behandling af osteoporose ved ikke-metastaserende cancer mammae

    DEFF Research Database (Denmark)

    Eiken, Pia Agnete; Hansen, Mogens; Kristensen, Bent

    2011-01-01

    The prevention of cancer-treatment-induced bone loss due to chemotherapy and long-term adjuvant breast cancer therapy has a high priority. We present an algorithm for the prevention and treatment of osteoporosis during treatment of nonmetastatic breast cancer....

  13. Lægers tavshedspligt ved behandling af unge kan være et dilemma

    DEFF Research Database (Denmark)

    Adolphsen, Caroline; Boisen, Kirsten; Svensson, Jannet

    2016-01-01

    Confidentiality is paramount in healthcare, yet according to Danish guidelines, health professionals have to inform parents about their child´s situation until the age of 18 years. This is in contrast to Danish legislation regarding informed consent, where adolescents aged 15 years can consent to...

  14. Behandling af ustabil angina pectoris. En spørgeskemaundersøgelse

    DEFF Research Database (Denmark)

    Nielsen, J D; Stoltenberg, Meredin; Juul, A

    1990-01-01

    Questionnaires about therapy in unstable angina pectoris were sent to 63 Danish medical departments and were answered by 52 departments (82.5%). Nitroglycerin is commonly used but only in half of the departments is Nitroglycerin administered intravenously. Calcium-receptor-blockers are used in more...

  15. Nonoperativ behandling af alvorlige stumpe pancreaslæsioner hos børn

    DEFF Research Database (Denmark)

    Penninga, Luit; Hillingsø, Jens

    2011-01-01

    Diagnosis and treatment of pancreatic trauma in children is challenging. Grade I and II lesions of the pancreas (Organ Injury Scale of the American Association of Trauma) are generally treated non-operatively. However, the optimal treatment of pancreatic lesions with involvement of the pancreatic...

  16. Glucagon-like peptide 1-baseret behandling af type 2-diabetes mellitus

    DEFF Research Database (Denmark)

    Knop, Filip Krag; Vilsbøll, Tina

    2007-01-01

    GLP-1 is secreted from the small intestine in response to ingestion of nutrients. It has a powerful insulinotropic effect and stimulates beta-cell growth and is therefore being developed for treatment of type 2 diabetes. The GLP-1 analogue, exenatide, is on the market in the USA as an add...

  17. Behandling og håndtering af kongenitte melanocytære naevi

    DEFF Research Database (Denmark)

    Bahn, Kamille-Amalie; Hædersdal, Merete; Schmidt, Grethe

    2016-01-01

    Congenital melanocytic naevi (CMN) appear in approximately 2.6% of Caucasians. There is a major demand for treatment but no vital indication. Laser therapy, curettage and excision are available treatment modalities, but there is no ideal treatment with documented long-term effect and without side...

  18. Retrograd intrarenal stenkirurgi--en minimalinvasiv metode til behandling af nyresten

    DEFF Research Database (Denmark)

    Jung, Helene U; Osther, Palle J S

    2009-01-01

    Retrograde intrarenal stone surgery (RIRS) is a safe and effective minimally invasive method for the treatment of minor (kidney stones. This modality is the preferred treatment for minor ESWL-resistant kidney stones where resistance is due e.g. to anatomical abnormalities or stones...

  19. Nye muligheder på vej til behandling af aldersrelateret maculadegeneration

    DEFF Research Database (Denmark)

    Rafique, Irfan; Munch, Inger Christine

    2013-01-01

    Currently, age-related macular degeneration (AMD) is untreatable, except for its neovascular complications. We review the primary pathogenesis of AMD and the pipeline of experimental interventions currently under way in clinical trials. They focus on four mechanisms: suppression of inflammation......, visual cycle modification, prevention of oxidative damage and neuroprotection. Regulatory approval is years away, but the development may be accelerated by re-purposing of medications designed for systemic diseases....

  20. Triage medfører hurtigere behandling af de mest syge

    DEFF Research Database (Denmark)

    Skriver, Claus; Lauritzen, Marlene Mauson Pankoke; Forberg, Jakob Lundager

    2011-01-01

    Systematic process triage is a relatively unknown concept in Denmark. Currently there are no national recommendations regarding triage models for use in the emergency department (ED). Four medium-sized EDs from different regions across the country cooperated in a joint venture to develop a new...... triage model, Danish Emergency Process Triage (DEPT). DEPT is inspired by the Swedish ADAPT system, but modified for a Danish context. This paper summarizes the cumulated experience with the new system....

  1. Ventetid og omkostninger ved diagnostik og behandling af stabil angina pectoris

    DEFF Research Database (Denmark)

    Søgaard, Rikke; Sanchez, Ricardo

    : Separate angiography (AG) and percutaneous coronary intervention (PCI) rather than combined procedures was associated with a significantly prolonged time to treatment, of on average 14 days, and increased costs of DKK 11,338 (95% KI 9,160;13,515). Similarly, re- referral rather than procedures being...... conducted at the centre to which the first referral was addressed was associated with significantly longer time to treatment, of on average 22 days, and increased costs of DKK 9,379 (95% KI 6,477;12,281). Conclusion: There seems to be a potential for optimizing the regimen for diagnosis and treatment...... of stable angina pectoris, which ceteris paribus would be associated with cost savings in the health care sector. However, these potentials should be examined in a larger- scale study....

  2. Behandling og diagnostik af tuberkulose: fremad med små skridt

    DEFF Research Database (Denmark)

    Andersen, Ase Bengård; Lillebæk, Troels; Bang, Didi

    2011-01-01

    Development of new drugs for the treatment of drug sensitive and drug resistent tuberculosis is badly needed. Substantial progress has been made in the field and presently six new drug components are in clinical phase I and II trials. Drugs approved for other indications e.g. newer fluoroquinolones...

  3. Behandling med valproat under graviditet: beskrivelse af fire cases med føtalt valproatsyndrom

    DEFF Research Database (Denmark)

    Sabers, Anne; Larsen, Katja; Blichfeldt, Susanne

    2009-01-01

    INTRODUCTION: Treatment with valproate is associated with an increased risk of teratogenicity compared to other antiepileptic drugs and can cause a complex of serious symptoms usually referred to as "foetal valproate symdrome" which is characterised by major and minor malformations in association...

  4. Begrænset evidens for bedste behandling af ukompliceret galdestenssygdom

    DEFF Research Database (Denmark)

    Rasmussen, Martin; Schulze, Svend; Bisgaard, Thue

    2016-01-01

    Gallbladder stones will rarely lead to colic pain attacks and even more seldom to complications. A conservative watchful waiting strategy may be an alternative to cholecystectomy for uncomplicated symptomatic gallbladder stone disease. Evidence for whether the optimal treatment should be cholecys...... be cholecystectomy or watchful waiting is weak. This narrative-condensed review critically analyses current evidence with special focus on epidemiological risk factors of developing symptoms or complications related to gallbladder stones. The evidence for treatment is discussed....

  5. Tidlig identifikation og behandling af kredsløbssvigt ved svær sepsis

    DEFF Research Database (Denmark)

    Haase, Nicolai; White, Jonathan; Perner, Anders

    2010-01-01

    Severe sepsis is a leading cause of death characterised by infection-induced endothelial and cardiac dysfunction leading to hypovolaemia, maldistribution of flow, tissue ischaemia and organ failure. A clinical approach with focus on cardiovascular diagnostics and rational goal-directed therapy...

  6. Forebyggelse og behandling af fedme hos børn og unge

    DEFF Research Database (Denmark)

    Michaelsen, Kim Fleischer; Mølgaard, Christian; Richelsen, Bjørn

    2006-01-01

    In the last 10 years, there has been a marked increase in the prevalence of obesity in children beginning at 3-4 years of age. The only realistic solution to the problem is prevention. Although there is limited evidence for the effectiveness of preventive programmes, there is a consensus...... that multisectorial action is urgently needed. This should include intervention at the family, school, municipal, regional and national levels, including the commercial sector and food companies. Treating childhood obesity has not been very successful, but some comprehensive community-based treatment programmes have...

  7. Disease-modifying anti-rheumatic drugs til behandling af ankyloserende spondylitis

    DEFF Research Database (Denmark)

    Madsen, Ole Rintek; Egsmose, Charlotte

    2009-01-01

    , there is no evidence that disease-modifying anti-rheumatic (DMARDs) have a therapeutic effect in AS. Clinical evidence that greater TNF-inhibitor effectiveness can be achieved by combining with a DMARD is lacking, but further studies should be performed. More research is needed to clarify the role of DMARDs...

  8. Medicinsk behandling af hypofosfatæmisk rakitis hos børn

    DEFF Research Database (Denmark)

    Rahbek, Elise Torp; Nielsen, Line Hougaard; Beck-Nielsen, Signe Sparre

    2014-01-01

    Hypophosphataemic rickets is a rare, genetic disorder resulting in defect bone mineralisation and rickets. The current medical treatment consists of phosphate supplementation and alfacalcidol, but side effects such as secondary hyperparat-hyroidism and nephrocalcinosis are common. This treatment...

  9. Udvikling og behandling af delirium hos kritisk syge børn

    DEFF Research Database (Denmark)

    Winther-Olesen, Marie; Afshari, Arash

    2012-01-01

    Delirium is a common and often under-recognised neuropsychiatric disorder in paediatric critical care, secondary to a general medical condition. Paediatric delirium (PD) is associated with high morbidity and mortality and prolonged stay at the intensive care unit. This review introduces the reader...

  10. Behandling af kardiogent shock med perkutan mekanisk cirkulationsstøtte

    DEFF Research Database (Denmark)

    Junker, Anders; Kaltoft, Anne Kjer; Hassager, Christian

    2013-01-01

    a ventricular assist device which can be inserted in the acute setting using the Impella device, a catheter-based flow pump. DanShock is a Danish multicentre study that will assess whether circulatory support using the Impella device will improve the outcome of cardiogenic shock compared to conventional...

  11. Lyden af musik - er lyden af idealisme

    DEFF Research Database (Denmark)

    Eigtved, Michael

    2015-01-01

    Programartiklen til Det Ny Teaters opsætning af Rodgers & Hammersteins The Sound of Music, undersøger musicalgenrens - og især de konkrete ophavsmænds- affinitet til fremstillingen af såvel idealistiske som ideologiske universer.......Programartiklen til Det Ny Teaters opsætning af Rodgers & Hammersteins The Sound of Music, undersøger musicalgenrens - og især de konkrete ophavsmænds- affinitet til fremstillingen af såvel idealistiske som ideologiske universer....

  12. Effekten af Ginkgo biloba-ekstrakt hos patienter med claudicatio intermittens

    DEFF Research Database (Denmark)

    Drabaek, H; Petersen, J R; Wïnberg, N

    1996-01-01

    of concentration, and inability to remember. Short-term memory was objectively assessed. We did not find any significant changes in either peripheral blood pressures, walking distances or the severity of leg pain. Systemic blood pressure was reduced both by placebo and GB-8. The impairment of concentration...... and the inability to remember were both reduced, when comparing results during active treatment to placebo. Short-term memory did not change significantly. In conclusion, our study has shown that treatment with the Ginkgo biloba extract GB-8 improves some cognitive functions in elderly patients with moderate...

  13. Sikkerhed af magnetisk resonans-skanning hos patienter med pacemaker og implanterbar defibrillator

    DEFF Research Database (Denmark)

    Al-Sabagh, Kifah Hekmat; Christensen, Britta Ege; Thøgersen, Anna Margrethe

    2010-01-01

    INTRODUCTION: The presence of a cardiac implantable device is ICD considered an absolute contraindication to magnetic resonance imaging (MRI). The purpose of this study was to evaluate the safety of performing MRI in patients with cardiac pacemakers and ICDs that had a compelling clinical need...... or to sense only mode to avoid MRI-induced competitive pacing and potential pro-arrhythmia. All devices were interrogated immediately before and after the MRI examination, which included measurement of sensitivity, pacing capture threshold (PCT) and lead impedance. RESULTS: MRI examinations were completed...

  14. Etablering af NIDCAP Træningscenter & NIDCAP Center på Aarhus Universitetshospital i Skejby

    DEFF Research Database (Denmark)

    Aagaard, Hanne; Jørgensen, Eva

    2012-01-01

    Det Neonatale afsnit på Aarhus Universitetshospital i Skejby er sammensat af 4 enheder – Neonatal Intensivafsnit (senge: 6), Neonatalafsnittet (senge: 21), Mor-barn afsnittet (senge: 8) og en ny etableret ordning, ’Tidlig Udskrivelse Til Hjemmet’ (TUTH), der har plads til 3 familier af gangen....... Fødeafdelingen på Aarhus Universitetshospital i Skejby har ca. 5.000 fødsler årligt, hvoraf ca. 300 børn fødes før uge 37 og ca. 80 er født meget for tidligt (neonatal behandling og pleje. Det tværfaglige team omfatter 115 sygeplejersker og 14...

  15. Styring af kommunal digitalisering

    DEFF Research Database (Denmark)

    Jæger, Birgit

    2017-01-01

    Digitalisering af både interne arbejdsprocesser og kommunikation med borgere og virksomheder har længe været en vigtig faktor i moderniseringen af den offentlige sektor. Derfor er der stort fokus på styring af digitaliseringen. Denne artikel undersøger, dels hvordan digitaliseringen i den kommunale...... sektor styres, og dels hvilke styringsparadigmer der kan identificeres. Med udgangspunkt i en konkret kommune analyseres styringen af digitalisering gennem et hierarki af offentlige digitaliseringsstrategier. Gennem udvikling af en helt ny form for organisering, en såkaldt Digitaliseringsforening...

  16. Ischaemic cardiac outcomes in patients with atrial fibrillation treated with vitamin K antagonism or factor Xa inhibition: results from the ROCKET AF trial

    Science.gov (United States)

    Mahaffey, Kenneth W.; Stevens, Susanna R.; White, Harvey D.; Nessel, Christopher C.; Goodman, Shaun G.; Piccini, Jonathan P.; Patel, Manesh R.; Becker, Richard C.; Halperin, Jonathan L.; Hacke, Werner; Singer, Daniel E.; Hankey, Graeme J.; Califf, Robert M.; Fox, Keith A.A.; Breithardt, Günter

    2014-01-01

    Aims We investigated the prevalence of prior myocardial infarction (MI) and incidence of ischaemic cardiovascular (CV) events among atrial fibrillation (AF) patients. Methods and results In ROCKET AF, 14 264 patients with nonvalvular AF were randomized to rivaroxaban or warfarin. The key efficacy outcome for these analyses was CV death, MI, and unstable angina (UA). This pre-specified analysis was performed on patients while on treatment. Rates are per 100 patient-years. Overall, 2468 (17%) patients had prior MI at enrollment. Compared with patients without prior MI, these patients were more likely to be male (75 vs. 57%), on aspirin at baseline (47 vs. 34%), have prior congestive heart failure (78 vs. 59%), diabetes (47 vs. 39%), hypertension (94 vs. 90%), higher mean CHADS2 score (3.64 vs. 3.43), and fewer prior strokes or transient ischaemic attacks (46 vs. 54%). CV death, MI, or UA rates tended to be lower in patients assigned rivaroxaban compared with warfarin [2.70 vs. 3.15; hazard ratio (HR) 0.86, 95% confidence interval (CI) 0.73–1.00; P = 0.0509]. CV death, MI, or UA rates were higher in those with prior MI compared with no prior MI (6.68 vs. 2.19; HR 3.04, 95% CI 2.59–3.56) with consistent results for CV death, MI, or UA for rivaroxaban compared with warfarin in prior MI compared with no prior MI (P interaction = 0.10). Conclusion Prior MI was common and associated with substantial risk for subsequent cardiac events. Patients with prior MI assigned rivaroxaban compared with warfarin had a non-significant 14% reduction of ischaemic cardiac events. PMID:24132190

  17. Ischaemic cardiac outcomes in patients with atrial fibrillation treated with vitamin K antagonism or factor Xa inhibition: results from the ROCKET AF trial.

    Science.gov (United States)

    Mahaffey, Kenneth W; Stevens, Susanna R; White, Harvey D; Nessel, Christopher C; Goodman, Shaun G; Piccini, Jonathan P; Patel, Manesh R; Becker, Richard C; Halperin, Jonathan L; Hacke, Werner; Singer, Daniel E; Hankey, Graeme J; Califf, Robert M; Fox, Keith A A; Breithardt, Günter

    2014-01-01

    We investigated the prevalence of prior myocardial infarction (MI) and incidence of ischaemic cardiovascular (CV) events among atrial fibrillation (AF) patients. In ROCKET AF, 14 264 patients with nonvalvular AF were randomized to rivaroxaban or warfarin. The key efficacy outcome for these analyses was CV death, MI, and unstable angina (UA). This pre-specified analysis was performed on patients while on treatment. Rates are per 100 patient-years. Overall, 2468 (17%) patients had prior MI at enrollment. Compared with patients without prior MI, these patients were more likely to be male (75 vs. 57%), on aspirin at baseline (47 vs. 34%), have prior congestive heart failure (78 vs. 59%), diabetes (47 vs. 39%), hypertension (94 vs. 90%), higher mean CHADS2 score (3.64 vs. 3.43), and fewer prior strokes or transient ischaemic attacks (46 vs. 54%). CV death, MI, or UA rates tended to be lower in patients assigned rivaroxaban compared with warfarin [2.70 vs. 3.15; hazard ratio (HR) 0.86, 95% confidence interval (CI) 0.73-1.00; P = 0.0509]. CV death, MI, or UA rates were higher in those with prior MI compared with no prior MI (6.68 vs. 2.19; HR 3.04, 95% CI 2.59-3.56) with consistent results for CV death, MI, or UA for rivaroxaban compared with warfarin in prior MI compared with no prior MI (P interaction = 0.10). Prior MI was common and associated with substantial risk for subsequent cardiac events. Patients with prior MI assigned rivaroxaban compared with warfarin had a non-significant 14% reduction of ischaemic cardiac events.

  18. Sammenligning af sertindols og olanzapins effekt på kognition

    DEFF Research Database (Denmark)

    Nielsen, René Ernst

    Der er gennem de senere år kommet tiltagende fokus, både nationalt og internationalt, på de kognitive deficits der ses hos patienter med skizofreni. Det er kendt at den farmakologiske behandling har indflydelse på kognition funktion, men det er endnu ikke fyldestgørende klarlagt hvorledes de enke...... enkelte atypiske antipsykotika påvirker kognitiv funktion. Der vil blive beskrevet studiedesign for SEROLA studiet, som sammenligner sertindol og olanzapin med kognition, målt med CANTAB, som primært outcome....

  19. Rivaroxaban versus warfarin in Japanese patients with nonvalvular atrial fibrillation for the secondary prevention of stroke: a subgroup analysis of J-ROCKET AF.

    Science.gov (United States)

    Tanahashi, Norio; Hori, Masatsugu; Matsumoto, Masayasu; Momomura, Shin-ichi; Uchiyama, Shinichiro; Goto, Shinya; Izumi, Tohru; Koretsune, Yukihiro; Kajikawa, Mariko; Kato, Masaharu; Ueda, Hitoshi; Iwamoto, Kazuya; Tajiri, Masahiro

    2013-11-01

    The overall analysis of the rivaroxaban versus warfarin in Japanese patients with atrial fibrillation (J-ROCKET AF) trial revealed that rivaroxaban was not inferior to warfarin with respect to the primary safety outcome. In addition, there was a strong trend for a reduction in the rate of stroke/systemic embolism with rivaroxaban compared with warfarin. In this subanalysis of the J-ROCKET AF trial, we investigated the consistency of safety and efficacy profile of rivaroxaban versus warfarin among the subgroups of patients with previous stroke, transient ischemic attack, or non-central nervous system systemic embolism (secondary prevention group) and those without (primary prevention group). Patients in the secondary prevention group were 63.6% of the overall population of J-ROCKET AF. In the secondary prevention group, the rate of the principal safety outcome (% per year) was 17.02 in rivaroxaban-treated patients and 18.26 in warfarin-treated patients (hazard ratio [HR] 0.95; 95% confidence interval [CI] 0.70-1.29), while the rate of the primary efficacy endpoint was 1.66 in rivaroxaban-treated patients and 3.25 in warfarin-treated patients (HR 0.51; 95% CI 0.23-1.14). There were no significant interactions in the principal safety and the primary efficacy endpoints of rivaroxaban compared to warfarin between the primary and secondary prevention groups (P=.090 and .776 for both interactions, respectively). The safety and efficacy profile of rivaroxaban compared with warfarin was consistent among patients in the primary prevention group and those in the secondary prevention group. Copyright © 2013 National Stroke Association. Published by Elsevier Inc. All rights reserved.

  20. Robust regulering af destillationskolonner

    DEFF Research Database (Denmark)

    Nielsen, Kim

    1987-01-01

    Sharke og Dixons metode benyttes til minimalrealisering af Laplace-overføringsmatricer. Ud fra denne metode til minimalrealisering opnåes en tilstandsbeskrivelse med første ordens Pade'-approximation af tidsforsinkelsen i Laplace-overføringsfunktionsmatricerne. Ud fra A.N Hansens frekvensanalyser...... bør denne regulator dog undersøges med eksakt beskrivelse af tidsforsinkelsen, hvilket ikke er nået indenfor denne opgave, væsenligst på grund af problemer med MIMOFAD Konklusion. Med Sharked og Dixons metode er der opnået kendskab til en simpel metode til minimalrealisering af Laplace......-overføringsmatricer. Metoden munder ud i et simpelt program der foretager minimalrealisering af Laplace-overføringsfunktionsmatricer med reelle adskildte poler. Anvendelsen af programmet resulterer i en tilstandsbeskrivelse af Laplace-overføringsfunktioner for velbeskrevne kolonner i litteraturen. Den opnåede...

  1. Vi lever af myter

    DEFF Research Database (Denmark)

    Bilde, Per

    2005-01-01

    En kritisk gennemgang af en kronik om regeringens forsknings- og universitetspolitik af Helge Sander, Minister for Videnskab, Teknologi og Udvikling: "Myter om universiteter står for fald" (Morgenavisen Jyllands-Posten 11/11 2005)...

  2. En verden af medier

    DEFF Research Database (Denmark)

    Tække, Jesper

    2009-01-01

    Bogen: 'En verden af medier – Medialiseringen af politik, sprog, religion og leg' anmeldes. Anmeldelsen kan læses på: http://ojs.statsbiblioteket.dk/index.php/mediekultur/article/view/1370/1499 Udgivelsesdato: 2009......Bogen: 'En verden af medier – Medialiseringen af politik, sprog, religion og leg' anmeldes. Anmeldelsen kan læses på: http://ojs.statsbiblioteket.dk/index.php/mediekultur/article/view/1370/1499 Udgivelsesdato: 2009...

  3. Rivaroxaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of ROCKET AF.

    Science.gov (United States)

    Hankey, Graeme J; Patel, Manesh R; Stevens, Susanna R; Becker, Richard C; Breithardt, Günter; Carolei, Antonio; Diener, Hans-Christoph; Donnan, Geoffrey A; Halperin, Jonathan L; Mahaffey, Kenneth W; Mas, Jean-Louis; Massaro, Ayrton; Norrving, Bo; Nessel, Christopher C; Paolini, John F; Roine, Risto O; Singer, Daniel E; Wong, Lawrence; Califf, Robert M; Fox, Keith A A; Hacke, Werner

    2012-04-01

    In ROCKET AF, rivaroxaban was non-inferior to adjusted-dose warfarin in preventing stroke or systemic embolism among patients with atrial fibrillation (AF). We aimed to investigate whether the efficacy and safety of rivaroxaban compared with warfarin is consistent among the subgroups of patients with and without previous stroke or transient ischaemic attack (TIA). In ROCKET AF, patients with AF who were at increased risk of stroke were randomly assigned (1:1) in a double-blind manner to rivaroxaban 20 mg daily or adjusted dose warfarin (international normalised ratio 2·0-3·0). Patients and investigators were masked to treatment allocation. Between Dec 18, 2006, and June 17, 2009, 14 264 patients from 1178 centres in 45 countries were randomly assigned. The primary endpoint was the composite of stroke or non-CNS systemic embolism. In this substudy we assessed the interaction of the treatment effects of rivaroxaban and warfarin among patients with and without previous stroke or TIA. Efficacy analyses were by intention to treat and safety analyses were done in the on-treatment population. ROCKET AF is registered with ClinicalTrials.gov, number NCT00403767. 7468 (52%) patients had a previous stroke (n=4907) or TIA (n=2561) and 6796 (48%) had no previous stroke or TIA. The number of events per 100 person-years for the primary endpoint in patients treated with rivaroxaban compared with warfarin was consistent among patients with previous stroke or TIA (2·79% rivaroxaban vs 2·96% warfarin; hazard ratio [HR] 0·94, 95% CI 0·77-1·16) and those without (1·44%vs 1·88%; 0·77, 0·58-1·01; interaction p=0·23). The number of major and non-major clinically relevant bleeding events per 100 person-years in patients treated with rivaroxaban compared with warfarin was consistent among patients with previous stroke or TIA (13·31% rivaroxaban vs 13·87% warfarin; HR 0·96, 95% CI 0·87-1·07) and those without (16·69%vs 15·19%; 1·10, 0·99-1·21; interaction p=0·08

  4. Quality of Vitamin K Antagonist Control and 1-Year Outcomes in Patients with Atrial Fibrillation: A Global Perspective from the GARFIELD-AF Registry.

    Directory of Open Access Journals (Sweden)

    Sylvia Haas

    Full Text Available Vitamin K antagonists (VKAs need to be individually dosed. International guidelines recommend a target range of international normalised ratio (INR of 2.0-3.0 for stroke prevention in atrial fibrillation (AF. We analysed the time in this therapeutic range (TTR of VKA-treated patients with newly diagnosed AF in the ongoing, global, observational registry GARFIELD-AF. Taking TTR as a measure of the quality of patient management, we analysed its relationship with 1-year outcomes, including stroke/systemic embolism (SE, major bleeding, and all-cause mortality.TTR was calculated for 9934 patients using 136,082 INR measurements during 1-year follow-up. The mean TTR was 55.0%; values were similar for different VKAs. 5851 (58.9% patients had TTR<65%; 4083 (41.1% TTR≥65%. The proportion of patients with TTR≥65% varied from 16.7% in Asia to 49.4% in Europe. There was a 2.6-fold increase in the risk of stroke/SE, 1.5-fold increase in the risk of major bleeding, and 2.4-fold increase in the risk of all-cause mortality with TTR<65% versus ≥65% after adjusting for potential confounders. The population attributable fraction, i.e. the proportion of events attributable to suboptimal anticoagulation among VKA users, was 47.7% for stroke/SE, 16.7% for major bleeding, and 45.4% for all-cause mortality. In patients with TTR<65%, the risk of first stroke/SE was highest in the first 4 months and decreased thereafter (test for trend, p = 0.021. In these patients, the risk of first major bleed declined during follow-up (p = 0.005, whereas in patients with TTR≥65%, the risk increased over time (p = 0.027.A large proportion of patients with AF had poor VKA control and these patients had higher risks of stroke/SE, major bleeding, and all-cause mortality. Our data suggest that there is room for improvement of VKA control in routine clinical practice and that this could substantially reduce adverse outcomes.ClinicalTrials.gov NCT01090362.

  5. Billeder af verdens svovl

    DEFF Research Database (Denmark)

    Samson, Kristine

    2014-01-01

    Film- og billedmediet har en særlig plads i skildringen af vores samfund og økonomi. Produktionen i de vestlige samfund består i dag primært af tegn, symboler, billeder og begær, mens de forgangne tiders maskinelle og, ikke mindst, manuelle bearbejdning af materialer – det vi stadigvæk umiddelbar...

  6. Globalisering af uddannelse

    DEFF Research Database (Denmark)

    Jensen, Henning Høgh

    2005-01-01

    Det globale marked for uddannelse er i voldsom vækst og er ved at blive et af Danmarks vigtigste vareområder. Hvorledes kan KVL agere i globaliseringen af uddannelse for at sikre en høj kvalitet af egne kandidater med gode jobmuligheder?...

  7. Kombinationseffekter af pesticider

    DEFF Research Database (Denmark)

    Kudsk, Per; Andersen, Helle Raun; Cedergreen, Nina

    Resumé: Effekten af 101 tokomponentblandinger og 20 trekomponentblandinger bestående af 22 forskellige pesticider blev undersøgt i 7 forskellige testsystemer. Effekterne af blandingerne blev sammenholdt med pesticidernes virkningsmekanismer/virkemåder med henblik på at undersøge, om det med...

  8. Renovering af enfamiliehuset

    DEFF Research Database (Denmark)

    Gram-Hanssen, Kirsten; Bech-Danielsen, Claus

    Meddelelsen beskriver et pilotprojekt, der undersøger hvilke arkitektoniske og økologiske overvejelser ejere af enfamiliehuse gør sig, når de renoverer deres huse. Undersøgelsen tager udgangspunkt i to kvarterer dels fra begyndelsen af 1950'erne, dels fra slutningen af 1960'erne. Gennem spørgeske...

  9. Evaluering af 'Tankerne på plads og hverdagen tilbage' - et kursusforløb for modermærkekræftramte

    DEFF Research Database (Denmark)

    Haslam, Trine Lolk

    af modermærkekræft til at genvinde trygheden og kontrollen i deres liv, ved at gøre dem bedre i stand til at forstå, acceptere og håndtere deres sygdom og behandling, samt at reducere de modermærkekræftramtes brug af sundhedsvæsenet til det nødvendige. Således ønskes det at påvirke adfærd på kort og...... behandlingen samt give en tilbagemelding på operationsforløbet. På kurset underviser desuden en psykolog, der behandler de psykologiske aspekter ved det at få en livstruende sygdom, hvilket ligeledes er af stor betydning for kursisterne. Desk study underbygger dette ved at pointere, at patientskole med...... formidling af viden via forskellige metoder, giver positiv effekt. Analysen i forbindelse med programteori 2 underbygger at kurset er tilrettelagt og gennemført som gruppebaseret undervisning, hvilket jf. desk study bidrager til øget egenomsorg. Den procesorienterede dialogiske tilrettelæggelse og...

  10. Efterforskning af drab i Kosovo

    DEFF Research Database (Denmark)

    Leth, Peter Mygind

    2000-01-01

    Gennemgang af baggrunden for den retsmedicinske mission til Kosovo i 1999, og af 50 obduktioner udført af forfatteren i denne forbindelse.......Gennemgang af baggrunden for den retsmedicinske mission til Kosovo i 1999, og af 50 obduktioner udført af forfatteren i denne forbindelse....

  11. Autoimmun hepatitis. Fremtroedelsesformer, diagnostik og behandling

    DEFF Research Database (Denmark)

    Poulsen, L O; Tage-Jensen, U; Vyberg, M

    1992-01-01

    A retrospective study concerning ten patients with autoimmune hepatitis (AiH), diagnosed during a 2 1/2-year period is presented. The age of the patients ranged from 25 to 82 years and nine of the patients were women. Their symptoms included jaundice, pruritus, fever, anorexia and fatigue during...

  12. En undersøgelse af livshistorier blandt patienter med skizofreni. (An examination of life stories among patients with schizophrenia)

    DEFF Research Database (Denmark)

    Holm, Tine; Bliksted, Vibeke Fuglsang; Thomsen, Dorthe Kirkegaard

    have less coherent life stories compared to healthy controls. 30 patients and 30 matched controls describe and rate up to 10 life story chapters and 3 self-defining memories (SDMs). We expect that patients will have less chronologically organized chapters and that they will rate degree of self......-continuity and causal coherence lower for both SDMs and life story chapters....

  13. En undersøgelse af livshistorier blandt patienter med skizofreni. (An examination of life stories among patients with schizophrenia)

    DEFF Research Database (Denmark)

    Holm, Tine; Bliksted, Vibeke Fuglsang; Thomsen, Dorthe Kirkegaard

    Lack of self-continuity is a defining feature in schizophrenia, which involves the experience that the past self is not meaningfully connected to the present self. Self-continuity may be established through the life story. In this study-in-progress we examine whether patients with schizophrenia...... have less coherent life stories compared to healthy controls. 30 patients and 30 matched controls describe and rate up to 10 life story chapters and 3 self-defining memories (SDMs). We expect that patients will have less chronologically organized chapters and that they will rate degree of self......-continuity and causal coherence lower for both SDMs and life story chapters....

  14. Risk factors for death, stroke, and bleeding in 28,628 patients from the GARFIELD-AF registry: Rationale for comprehensive management of atrial fibrillation.

    Directory of Open Access Journals (Sweden)

    Jean-Pierre Bassand

    Full Text Available The factors influencing three major outcomes-death, stroke/systemic embolism (SE, and major bleeding-have not been investigated in a large international cohort of unselected patients with newly diagnosed atrial fibrillation (AF.In 28,628 patients prospectively enrolled in the GARFIELD-AF registry with 2-year follow-up, we aimed at analysing: (1 the variables influencing outcomes; (2 the extent of implementation of guideline-recommended therapies in comorbidities that strongly affect outcomes. Median (IQR age was 71.0 (63.0 to 78.0 years, 44.4% of patients were female, median (IQR CHA2DS2-VASc score was 3.0 (2.0 to 4.0; 63.3% of patients were on anticoagulants (ACs with or without antiplatelet (AP therapy, 24.5% AP monotherapy, and 12.2% no antithrombotic therapy. At 2 years, rates (95% CI of death, stroke/SE, and major bleeding were 3.84 (3.68; 4.02, 1.27 (1.18; 1.38, and 0.71 (0.64; 0.79 per 100 person-years. Age, history of stroke/SE, vascular disease (VascD, and chronic kidney disease (CKD were associated with the risks of all three outcomes. Congestive heart failure (CHF was associated with the risks of death and stroke/SE. Smoking, non-paroxysmal forms of AF, and history of bleeding were associated with the risk of death, female sex and heavy drinking with the risk of stroke/SE. Asian race was associated with lower risks of death and major bleeding versus other races. AC treatment was associated with 30% and 28% lower risks of death and stroke/SE, respectively, compared with no AC treatment. Rates of prescription of guideline-recommended drugs were suboptimal in patients with CHF, VascD, or CKD.Our data show that several variables are associated with the risk of one or more outcomes, in terms of death, stroke/SE, and major bleeding. Comprehensive management of AF should encompass, besides anticoagulation, improved implementation of guideline-recommended therapies for comorbidities strongly associated with outcomes, namely CHF, VascD, and

  15. Self-reported physical activity and major adverse events in patients with atrial fibrillation: a report from the EURObservational Research Programme Pilot Survey on Atrial Fibrillation (EORP-AF) General Registry.

    Science.gov (United States)

    Proietti, Marco; Boriani, Giuseppe; Laroche, Cécile; Diemberger, Igor; Popescu, Mircea I; Rasmussen, Lars H; Sinagra, Gianfranco; Dan, Gheorghe-Andrei; Maggioni, Aldo P; Tavazzi, Luigi; Lane, Deirdre A; Lip, Gregory Y H

    2017-04-01

    Physical activity is protective against cardiovascular (CV) events, both in general population and in high-risk CV cohorts. However, the relationship between physical activity with major adverse outcomes in atrial fibrillation (AF) is not well-established. Our aim was to analyse this relationship in a 'real-world' AF population. Second, we investigated the influence of physical activity on arrhythmia progression. We studied all patients enrolled in the EURObservational Research Programme on AF (EORP-AF) Pilot Survey. Physical activity was defined as 'none', 'occasional', 'regular', and 'intense', based on patient self-reporting. Data on physical activity were available for 2442 patients: 38.9% reported none, 34.7% occasional, 21.7% regular, and 4.7% intense physical activity. Prevalence of the principal CV risk factors progressively decreased from none to intense physical activity. Lower rates of CV death, all-cause death, and composite outcomes were found in AF patients who reported regular and intense physical activity (P < 0.0001). Increasing physical activity was inversely associated with CV death/any thromboembolic event (TE)/bleeding in the whole cohort, irrespective of gender, paroxysmal AF, elderly age, or high stroke risk. Any level of physical activity intensity was significantly associated with lower risk of CV death/any TE/bleeding at 1-year follow-up. Physical activity was not significantly associated with arrhythmia progression. Atrial fibrillation patients taking regular exercise were associated with a lower risk of all-cause death, even when we considered various subgroups, including gender, elderly age, symptomatic status, and stroke risk class. Efforts to increase physical activity among AF patients may improve outcomes in these patients. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2016. For permissions please email: journals.permissions@oup.com.

  16. Akut kirurgisk behandling ved malignt cerebralt infarkt

    DEFF Research Database (Denmark)

    Lilja-Cyron, Alexander; Eskesen, Vagn; Hansen, Klaus

    2017-01-01

    Malignant stroke is an intracranial herniation syndrome caused by cerebral oedema after a large hemispheric or cerebellar stroke. Malignant middle cerebral artery infarction is a devastating disease with a mortality around 80% despite intensive medical treatment. Decompressive craniectomy reduces...... mortality and improves functional outcome - especially in younger patients (age ≤ 60 years). Decompression of the posterior fossa is a life-saving procedure in patients with malignant cerebellar infarctions and often leads to good neurological outcome....

  17. Installation af opvaskemaskine

    DEFF Research Database (Denmark)

    Christiansen, J.; Skibstrup Eriksen, S.; Nielsen, F.

    Denne SBI-anvisning er et led i en serie om modernisering af installationerne i den ældre boligmasse. Den henvender sig til både beboere, husejere, VVS-installatører og andre interesserede. Anvisningen indeholder almene afsnit om valg og placering af opvaskemaskine, sagsforløb ved installation......, forhold til myndigheder, priser, finansieringsmuligheder m.m. Anvisningen indeholder endvidere tekniske afsnit om vandinstallation, afløb og elinstallation i forbindelse med installation af opvaskemaskine....

  18. Behandling med kosmetiske bløddelsfyldere

    DEFF Research Database (Denmark)

    Thyssen, Jacob Pontoppidan; Christensen, Lise H; Zachariae, Claus O C

    2007-01-01

    An increasing number of patients undergo soft-tissue augmentation. The quality depends on the applied filler substance, the compliance of the patient and the physician. Long-term adverse reactions are referred to as nodules or granulomas. Nodules following degradable gels and polyacrylamide hydro...... hydrogel are always caused by bacteria. Nodules following inert, hydrophobic silicone gel and combination gels may emerge years after the injection. They are often caused by a low-grade infection with ensuing enhanced fibrosis and treatment requires a specialist....

  19. Raman af hvide pigmenter

    DEFF Research Database (Denmark)

    Reeler, Nini Elisabeth Abildgaard; Nielsen, Ole Faurskov; Sauer, Stephan P. A.

    2013-01-01

    Et samspil mellem kunst og kemi. I et samarbejde mellem Statens Museum for Kunst og Kemisk Institut på KU er Ramanspek-troskopi brugt til at definere sammensætningen af blandinger af blyhvidt og calcit i maleriers hvide pigmenter.......Et samspil mellem kunst og kemi. I et samarbejde mellem Statens Museum for Kunst og Kemisk Institut på KU er Ramanspek-troskopi brugt til at definere sammensætningen af blandinger af blyhvidt og calcit i maleriers hvide pigmenter....

  20. Hepatorenalt syndrom: diagnose, behandling og forebyggelse

    DEFF Research Database (Denmark)

    Egerod Israelsen, Mads; Gluud, Lise Lotte; Bendtsen, Flemming

    2013-01-01

    Cirrhosis, ascites and renal impairment are associated with high morbidity and mortality. The hepatorenal syndrome (HRS) is a type of renal failure that affects patients with cirrhosis and ascites. This paper provides an update on evidence-based interventions in HRS. A number of factors can...

  1. Hepatorenalt syndrom: diagnose, behandling og forebyggelse

    DEFF Research Database (Denmark)

    Egerod Israelsen, Mads; Gluud, Lise Lotte; Bendtsen, Flemming

    2013-01-01

    Cirrhosis, ascites and renal impairment are associated with high morbidity and mortality. The hepatorenal syndrome (HRS) is a type of renal failure that affects patients with cirrhosis and ascites. This paper provides an update on evidence-based interventions in HRS. A number of factors can preci...

  2. Diagnose, behandling og prognose ved fibromyalgi

    DEFF Research Database (Denmark)

    Danneskiold-Samsøe, Bente; Bartels, Else Marie; Amris, Kirstine

    2010-01-01

    It is important to recognize the diagnosis of fibromyalgia (FM) to adequately advise patients with this chronic pain disease. FM coexists with other rheumatic diseases and may therefore serve as a confounder in connection with estimation of disease activity. The aetiology and pathogenesis of FM...

  3. Nyrefunktionen under behandling med angiotensinkonverterende enzymhaemmere

    DEFF Research Database (Denmark)

    Rasmussen, K; Heitmann, M; Nielsen, J I

    1995-01-01

    -inhibitors on renal haemodynamics and kidney function, which may be positive, with preservation of kidney function in diabetic and other chronic nephropathy, or negative, for example in cases with atherosclerotic stenosis of large or small renal arteries. It is concluded, that in cases of diabetic nephropathy an ACE......The use of ACE-inhibitors has increased greatly during the last years. They were first used in treating hypertension, but nowadays cardiac diseases, mainly cardiac failure, are common indications. This means that the drugs are used in the treatment of more elderly patients who often have...... generalised atherosclerosis. This means that the patients must be controlled more often after initiation of treatment, especially concerning kidney function, since treatment with ACE-inhibitors can cause pronounced changes in renal haemodynamics and kidney function. This review focuses on the effects of ACE...

  4. Ny viden om spasticitet og dens behandling

    DEFF Research Database (Denmark)

    Lorentzen, Jakob; Willerslev-Olsen, Maria; Crone, Clarissa

    2012-01-01

    Spasticity is a frequently used diagnosis, and anti-spastic medication is used widespread. In this systematic review article we highlight difficulties in diagnosing spasticity correctly and thus limit the value of the diagnosis in ensuring the best possible treatment. We review recent neuroscience...... research and conclude that it is necessary to develop better tools for clinical diagnosis of spasticity in order to avoid potential malpractice and to limit treatment with anti-spastic drugs for patients with documented increased reflex-mediated muscle tone as their main annoyance....

  5. Bestyrer af egen ro

    DEFF Research Database (Denmark)

    Søndergård, Birger; L. Friis, Klaus

    2000-01-01

    Evnen til at håndtere en indre uro synes at være blevet en væsentlig egenskab i forhold til udviklingen af vort samfund og de hastige brud i kontinuiteten af et liv, der leves. arbejdsforhold. stress. arbejdsmiljø. arbejdsliv...

  6. Anvendelse af genmodificerede planter

    DEFF Research Database (Denmark)

    Møller, F.

    I rapporten vurderes mulighederne for at gennemføre velfærdsøkonomiske analyser af anvendelsen af genmodificerede planter. Der gøres rede for kravene til konse-kvensbeskrivelsen og for mulighederne for at prissætte såvel de markedsrelaterede som de ikke-markedsrelaterede konsekvenser. Mulighederne...

  7. Evaluering af mentorordningen

    DEFF Research Database (Denmark)

    Albæk, Karsten; Bach, Henning Bjerregaard; Bille, Rebekka

    Formålet med denne rapport er at give et detaljeret og aktuelt billede af mentorordningens anvendelse, herunder de involveredes vurdering af ordningen. Undersøgelsen viser blandt andet, at mentorordningen primært bruges til borgere, der er langt fra arbejdsmarkedet og har komplekse sociale eller ...

  8. Dialektisk billede af Benjamin

    DEFF Research Database (Denmark)

    Bøggild, Jacob

    2004-01-01

    Anmeldelse af Lars Brückner: "Løse blade. Læseren, kritikeren og fortælleren Walter Benjamin"......Anmeldelse af Lars Brückner: "Løse blade. Læseren, kritikeren og fortælleren Walter Benjamin"...

  9. Evaluering af VIFT

    DEFF Research Database (Denmark)

    Pedersen, Michael Svendsen

    Denne rapport indeholder en ekstern evaluering af aktiviteter i VIFT, Videncenter for bedre undervisning af tosprogede elever, der er etableret som et samarbejde mellem Videncenter for tosprogethed & interkulturalitet (UC2) ved Professionshøjskolen København (UCC), tidligere CVU København & Nords...

  10. Kvalitetsvurdering af sundhedsoplysende materiale

    DEFF Research Database (Denmark)

    Osler, Merete; Bech, Lars; Sybille, Bojlén

    1990-01-01

    Lægeforeningens Hygiejnekomités arbejdsgruppe vedrørende sundhedsoplysning har udarbejdet en "huskeliste" til brug for en kvalitetsvurdering af skriftligt sundhedsoplysende materiale......Lægeforeningens Hygiejnekomités arbejdsgruppe vedrørende sundhedsoplysning har udarbejdet en "huskeliste" til brug for en kvalitetsvurdering af skriftligt sundhedsoplysende materiale...

  11. Kvalitetssikring af sygeplejerskeuddannelsen

    DEFF Research Database (Denmark)

    Scheel, Linda Schumann

    2001-01-01

    På Sønderborg Sygehus er der gennemført en detaljeret undersøgelse af praktikuddannelsen, hvor resultaterne viser både sygeplejerskers og studerendes opfattelse af praktikforløbet. Der blev i den forbindelse udarbejdet detaljerede beskrivelser om læringsforholdene og udvik-let en evalueringsmetod...

  12. Coaching af dit studieliv

    DEFF Research Database (Denmark)

    Hansen, Rasmus Thorning

    2008-01-01

    En generel beskrivelse af de problemer specialestuderende sidder med og hvorledes coaching kan hjælpe med at (gen)skabe motivation og fokus......En generel beskrivelse af de problemer specialestuderende sidder med og hvorledes coaching kan hjælpe med at (gen)skabe motivation og fokus...

  13. Fundering af mindre bygninger

    DEFF Research Database (Denmark)

    Larsen, J.; Ballisager, C.C.

    Denne SBI-anvisning indeholder en gennemgang af de jordbunds- og grundvandsforhold, som er bestemmende for funderingen af en bygning. Specielt gennemgås de betingelser, der skal være opfyldt, for at man på forsvarlig måde kan fundere en mindre bygning i traditionel udformning. Publikationen...

  14. Administration af informationsmodeller

    DEFF Research Database (Denmark)

    Hundebøl, Jesper

    2013-01-01

    En informationsmodel er i denne sammenhæng en digital repræsentation af et givent byggeri. Både offentlige og private bygherrer anvender informationsmodeller, når der 'bygges digitalt'. I denne artikel undersøges det, hvilke konkrete udfordringer der følger af digitaliseringen, hvor gennemgribend...

  15. Evaluering af afdeling H

    DEFF Research Database (Denmark)

    Kjær Minke, Linda; Birkmose, Sofie Meldal

    2016-01-01

    Som led i Kriminalforsorgens flerårsaftale 2013-2016 blev det åbne statsfængsel Søbysøgård i januar 2015 udvidet med 42 lukkede pladser i den nybyggede afdeling H. Nærværende evaluering kortlægger de erfaringer personalet og indsatte har gjort sig i løbet af det første år. Etableringen af den...... lukkede fængselsafdeling H giver en unik mulighed for at følge henholdsvis hvilke faktorer, der bidrager til udvikling af fængselskultur, og hvordan de respektive faktorer influerer på udvikling af fængselskulturen. Evalueringens metoder består af kvalitative og kvantitative metoder såsom dokumentanalyse...

  16. Sundhedseffekter af luftforurening-beregningspriser

    DEFF Research Database (Denmark)

    Andersen, M. S.; Frohn, L. M.; Jensen, S. S.

    Denne rapport afrapporterer det fortsatte arbejde med udvikling af miljøøkonomiske beregningspriser. På grundlag af EcoSense 4.0 fra ExternE-projektet, er der foretaget nye beregninger af eksternaliteter ved luftforurening med sundhedseffekter. Samtidig giver rapporten en vurdering af luftspredni......Denne rapport afrapporterer det fortsatte arbejde med udvikling af miljøøkonomiske beregningspriser. På grundlag af EcoSense 4.0 fra ExternE-projektet, er der foretaget nye beregninger af eksternaliteter ved luftforurening med sundhedseffekter. Samtidig giver rapporten en vurdering af...

  17. Efficacy and Safety of Rivaroxaban Versus Warfarin in Patients Taking Nondihydropyridine Calcium Channel Blockers for Atrial Fibrillation (from the ROCKET AF Trial).

    Science.gov (United States)

    Washam, Jeffrey B; Hellkamp, Anne S; Lokhnygina, Yuliya; Piccini, Jonathan P; Berkowitz, Scott D; Nessel, Christopher C; Becker, Richard C; Breithardt, Günter; Fox, Keith A A; Halperin, Jonathan L; Hankey, Graeme J; Mahaffey, Kenneth W; Singer, Daniel E; Patel, Manesh R

    2017-08-15

    Non-dihydropyridine calcium channel blockers (non-DHP CCBs) possess combined P-glycoprotein and moderate CYP3A4 inhibition, which may lead to increased exposure of medications that are substrates for these metabolic pathways, such as rivaroxaban. We evaluated the use and outcomes of non-DHP CCBs in patients with atrial fibrillation (AF) in Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF). We assessed clinical outcomes in patients who received non-DHP CCBs and the impact on the efficacy and safety of rivaroxaban compared with warfarin. Stroke or noncentral nervous system (CNS) systemic embolism (SE), major or nonmajor clinically relevant (NMCR) bleeding, all-cause death, and major bleeding were compared according to non-DHP CCB use. At randomization, 1,308 patients (9.2%) were taking a non-DHP CCB. They were more likely to be women, have diabetes and COPD, and less likely to have heart failure and had a lower mean CHADS 2 score (3.3 vs 3.5). Non-DHP CCB use was not associated with an increased risk of stroke/non-CNS SE (p = 0.11) or the composite outcome of NMCR or major bleeding (p = 0.087). Non-DHP CCB use was associated with an increased risk of major bleeding (adjusted hazard ratio 1.50, 95% CI 1.11 to 2.04) and intracranial hemorrhage (adjusted hazard ratio 2.84, 95% CI 1.53 to 5.29). No significant difference was observed in the primary efficacy (stroke or non-CNS SE; adjusted interaction p value = 0.38) or safety outcome (NMCR or major bleeding; adjusted interaction p value = 0.14) between rivaroxaban and warfarin with non-DHP CCB use. In conclusion, although the overall use of non-DHP CCBs was associated with an increased risk of major bleeding and intracranial hemorrhage, the use was not associated with a significant change in the safety or efficacy of rivaroxaban compared with warfarin observed in ROCKET AF. Copyright © 2017

  18. Farmakologisk behandling av antisosiale lidelser : en litteraturstudie av evidensgrunnlaget for famakologisk behandling av psykopati og assosierte antisosiale personlighetstrekk og atferdsmønster

    OpenAIRE

    Romberg, Sara Montes

    2016-01-01

    Bakgrunn: Psykoterapeutiske og atferdsbaserte intervensjoner har vist seg å ha liten effekt ved antisosiale lidelser. Individer med antisosiale lidelser anses derfor som en relativt behandlingsresistent pasientgruppe, hvilket tyder på et behov for utvikling av alternative behandlingstilnærminger. Med bakgrunn i dette søker følgende studie å utforske evidensgrunnlaget for farmakologiske behandling av antisosiale lidelser og trekk. Metode: Litteratursøk i databasene BIBSYS, ProQuest, Web of ...

  19. Compreensão de fala em situação de mensagem competitiva em afásicos Comprehension of competitive messages in aphasic patients

    Directory of Open Access Journals (Sweden)

    Karin Zazo Ortiz

    2008-01-01

    Full Text Available OBJETIVO: verificar o desempenho de pacientes afásicos com distúrbios leves de compreensão em tarefas de figura-fundo e atenção seletiva para sons verbais em escuta de mensagem competitiva. MÉTODOS: foram incluídos neste estudo pacientes afásicos com distúrbio de compreensão leve, identificados através da aplicação do teste M1-Alpha. Além disso, deveriam apresentar audiometria tonal nas freqüências de 500Hz, 1KHZ, 2KHZ, compatível com a realização de testes auditivos centrais, medidas de imitância acústica normais e reflexos contralateral presentes bilateralmente. Foi utilizado o teste de identificação de sentenças PSI (Pediatric Speech Inteligibility - versão em português. Inicialmente, todos os pacientes identificaram as frases que compõem o PSI à viva voz. Em seguida, foram submetidos ao Teste de Escuta Monótica e Dicótica. RESULTADOS: os pacientes apresentaram dificuldades de compreensão estatisticamente significantes na situação de mensagem competitiva ipsilateral, nas situações 0dB e -10dB, além de dificuldades de compreensão também na situação de mensagem competitiva contralateral MCC (- 40 dB. CONCLUSÕES: os pacientes afásicos apresentaram dificuldade na compreensão de estímulos verbais em tarefas de figura-fundo e atenção seletiva, perdendo parte da informação nestas condições. Os achados dessa pesquisa puderam contribuir de forma a elucidar em como a lesão cerebral e, conseqüentemente, o prejuízo de habilidades perceptuais auditivas pode interferir na compreensão de pacientes afásicos no dia-a-dia, em que várias mensagens concorrem de forma competitiva.PURPOSE: to analyze the performance of aphasic patients with mild comprehension disorders in tasks of back-image and selective attention to verbal sounds in listening tasks with competitive message. METHODS: the patients were submitted to an audiological assessment; acoustic immitance measures and measurements of acoustic reflex. An

  20. Kritik af pseudovidenskab censureret

    DEFF Research Database (Denmark)

    Emmeche, Claus

    2014-01-01

    Weekendavisen har afvist at bringe et indlæg af Jørgen Øllgaard om deres egen dækning af Helmuth Nyborg og sagen om hans forskning i IQ, som UVVU har dømt uredelig. Måske er UVVU bedre til at tage sig af bevidst fusk i god normal videnskab end til sager, som angår "patologisk videnskab" ("fringe...... science") med varierende grader af marginalitet. Dette begreb kan både dække hvad Kuhn ville kalde "revolutionær videnskab", som blot endnu ikke er anerkendt men starter med nogle få forskeres vilde ideer, og så især det, som dårligt nok kan testes, efterprøves, og som måske langsomt opløses hvis det...

  1. Test af Software

    DEFF Research Database (Denmark)

    Dette dokument udgør slutrapporten for netværkssamarbejdet ”Testnet”, som er udført i perioden 1.4.2006 til 31.12.2008. Netværket beskæftiger sig navnlig med emner inden for test af indlejret og teknisk software, men et antal eksempler på problemstillinger og løsninger forbundet med test af...... administrativ software indgår også. Rapporten er opdelt i følgende 3 dele: Overblik. Her giver vi et resumé af netværkets formål, aktiviteter og resultater. State of the art af software test ridses op. Vi omtaler, at CISS og netværket tager nye tiltag. Netværket. Formål, deltagere og behandlede emner på ti...

  2. Realisering af en boligpolitik

    DEFF Research Database (Denmark)

    Avnby, F.(red.)

    Meddelelsen bringer indlæggene på en konference afholdt i anledning af Bygge-boligåret '88 og Køge bys 700 års jubilæum om realisering af Køge kommunes boligpolitik med blandede, tæt lave bebyggelser. Indlæggene illustreres med tegninger og fotos fra de bebyggelser, der blev besøgt.......Meddelelsen bringer indlæggene på en konference afholdt i anledning af Bygge-boligåret '88 og Køge bys 700 års jubilæum om realisering af Køge kommunes boligpolitik med blandede, tæt lave bebyggelser. Indlæggene illustreres med tegninger og fotos fra de bebyggelser, der blev besøgt....

  3. Termisk forgasning af biomasse

    DEFF Research Database (Denmark)

    Indlæggene i referatet er gengivet efter båndoptagelser. Der er dog foretaget nogle enklte omskrivninger af hensyn til læseligheden. Foredragsholdernes overheads er endvidere blevet lagt ind i referatet....

  4. Energirenovering af Sems Have

    DEFF Research Database (Denmark)

    Jensen, Søren Østergaard; Rose, Jørgen; Mørck, Ove

    energirenovering af boligblokke. Vejledningen omfatter optimering af økonomi, energibesparelser og CO2-reduktion ved renovering af boligblokke til lavenerginiveau. Fokus er på elementbyggeri fra 60-70erne samt murstensbyggeri. Der tages udgangspunkt i to konkrete renoverings-cases: Traneparken og Sems Have, hvor...... renoveringen er udført på to principielt forskellige måder: Traneparken med udvendig efterisolering til næsten lavenergiklasse 2015 niveau (nuværende BR2015 krav), Sems Have med helt ny klimaskærm og nye installationer til bygningsklasse 2020 niveau. Begge bebyggelser har fået nyt ventilationsanlæg samt PV......-anlæg. Nærværende rapport beskriver renoveringen af Sems Have....

  5. Supervision af psykoterapi

    DEFF Research Database (Denmark)

    SUPERVISION AF PSYKOTERAPI indtager en central position i uddannelsen og udviklingen af psykoterapeuter. Trods flere lighedspunkter med psykoterapi, undervisning og konsultation er psykoterapisupervision et selvstændigt virksomhedsområde. Supervisor må foruden at være en trænet psykoterapeut kende...... supervisionens rammer og indplacering i forhold til organisation og samfund. En række kapitler drejer sig om supervisors opgaver, roller og kontrolfunktion, supervision set fra supervisandens perspektiv samt betragtninger over relationer og processer i supervision. Der drøftes fordele og ulemper ved de...... forskellige måder, hvorpå en sag kan fremlægges. Bogens første del afsluttes med refleksioner over de etiske aspekter ved psykoterapisupervision. Bogens anden del handler om de særlige forhold, der gør sig gældende ved supervision af en række specialiserede behandlingsformer eller af psykoterapi med bestemte...

  6. Sammenligning af kvaliteten af kommunernes sagsbehandling

    DEFF Research Database (Denmark)

    Rasmussen, Martin

    flere forskellige spørgsmål fra praksis¬undersøgelser i samme sammenligning. Vi foreslår også, at metoder til såkaldte ’multi¬ple sammenligninger’ bruges til dele af undersøgelserne. Det er en ældre og ikke særlig kendt metode, men den er særdeles relevant både i den konkrete anvendelse og i andre...

  7. Lyden af ro

    DEFF Research Database (Denmark)

    Have, Iben

    2017-01-01

    Et projekt, der skal undersøge lyden af ro - både den ydre og den indre, den iscenesatte og den naturlige. Lyden af ro i arkitekturen, i film, i reklamer og i selvhjælpsmedier, i lyddesign, i musik og i stemmer. Og både den lydlige ro vi opsøger, og den der virker skræmmende....

  8. Vitalisering af rettetheder

    DEFF Research Database (Denmark)

    Kristensen, René; Tønnesvang, Jan

    2012-01-01

    Kapitlet handler om at anvende det selvpsykologiske teorigrundlag i samspil med de systemisk konstruktionistiske ideer i arbejdet med at udvikle organisationer og samtidig kvalificere anvendelsen af PUMA -pædagogisk udredning i inklusionssammenhænge.......Kapitlet handler om at anvende det selvpsykologiske teorigrundlag i samspil med de systemisk konstruktionistiske ideer i arbejdet med at udvikle organisationer og samtidig kvalificere anvendelsen af PUMA -pædagogisk udredning i inklusionssammenhænge....

  9. Hvor blev tilliden af?

    DEFF Research Database (Denmark)

    Poulfelt, Flemming

    2015-01-01

    Har man tillid til hinanden på en arbejdsplads, glider tingene typisk lettere. Alligevel måler og vejer ledere deres medarbejdere på et væld af parametre.......Har man tillid til hinanden på en arbejdsplads, glider tingene typisk lettere. Alligevel måler og vejer ledere deres medarbejdere på et væld af parametre....

  10. Hvor blev tilliden af?

    DEFF Research Database (Denmark)

    Poulfelt, Flemming

    2015-01-01

    Ledelse: Har parterne tillid til hinanden på en arbejdsplads, glider tingene typisk lettere. Alligevel måler og vejer ledere deres medarbejdere på et væld af parametre.......Ledelse: Har parterne tillid til hinanden på en arbejdsplads, glider tingene typisk lettere. Alligevel måler og vejer ledere deres medarbejdere på et væld af parametre....

  11. Genlyden af et nej

    DEFF Research Database (Denmark)

    Östman, Lars

    2011-01-01

    Europa og den vestlige verden er ramt af en økonomisk krise. Det er en krise, der er anderledes, end den vi har været vant til fx fra 1980'erne.......Europa og den vestlige verden er ramt af en økonomisk krise. Det er en krise, der er anderledes, end den vi har været vant til fx fra 1980'erne....

  12. Rivaroxaban versus warfarin in Japanese patients with non-valvular atrial fibrillation in relation to hypertension: a subgroup analysis of the J-ROCKET AF trial.

    Science.gov (United States)

    Matsumoto, Masayasu; Hori, Masatsugu; Tanahashi, Norio; Momomura, Shin-Ichi; Uchiyama, Shinichiro; Goto, Shinya; Izumi, Tohru; Koretsune, Yukihiro; Kajikawa, Mariko; Kato, Masaharu; Ueda, Hitoshi; Iekushi, Kazuma; Yamanaka, Satoshi; Tajiri, Masahiro

    2014-05-01

    The majority of the patients enrolled in the rivaroxaban vs. warfarin in Japanese patients with atrial fibrillation (J-ROCKET AF) trial had hypertension. In this subgroup analysis, we investigated differences in the safety and efficacy of rivaroxaban and warfarin in subjects with and without hypertension. The baseline blood pressure (BP) measurements of patients with hypertension in the rivaroxaban and warfarin groups were 130/77 mm Hg and 131/77 mm Hg, respectively, whereas those of patients without hypertension were 123/74 mm Hg and 124/73 mm Hg, respectively. The incidence rates of the principal safety outcomes in the rivaroxaban and warfarin groups were 18.39% per year and 16.81% per year, respectively, among patients with baseline hypertension (hazard ratio (HR): 1.10; 95% confidence interval (CI): 0.84-1.45) and 16.71% per year and 15.00% per year, respectively, among patients without hypertension at baseline (HR: 1.14; 95% CI: 0.66-1.97), indicating no significant interaction (P=0.933). The incidence rates of the primary efficacy endpoints in the rivaroxaban group and the warfarin group were 0.54% per year and 2.24% per year, respectively, in patients without baseline hypertension (HR: 0.25; 95% CI: 0.03-2.25), and 1.45% per year and 2.71% per year, respectively, in patients with baseline hypertension (HR: 0.54; 95% CI: 0.25-1.16), indicating no significant interaction (P=0.509). In conclusion, the safety and efficacy profile of rivaroxaban was similar to that of warfarin, independent of baseline hypertensive status.

  13. Ledelse af Organisationens Kreativitet

    DEFF Research Database (Denmark)

    Hedemann, Lars

    2008-01-01

    mod, at give et overordnet indblik i nogle af de overvejelser man som leder står overfor, når der står kreativitet på dagsordenen. Et af de underpunkter som respondenterne i DEA' undersøgelse efterspørger i forhold til kreativitet, er øget viden om styring og optimering af de processer som skal...... transformere organisationens kreativitet om til succesfulde innovationer. At et øget fokus på organisationens processer kan have en stimulerende effekt på kreativiteten synes der i litteraturen såvel som blandt praktikere at være enighed om, men ligeså vel er der enighed om, at vil man virkeligt gøre en...... forskel, så er man som leder nødt til at arbejde mere målrettet med de medarbejdere som forventes at præstere et kreativt udbytte. Inspireret af analyseværktøjet "KEYS, Assessing the Work Environment for Creativity" udviklet af den amerikanske psykolog og ledelsesforsker ved Harvard University, Teresa...

  14. Myopati hos en patient i behandling med simvastatin og fluconazol

    DEFF Research Database (Denmark)

    Pedersen, Jens Kristian; Lydolph, Magnus Christian; Somnier, Finn

    2016-01-01

    A 69-year-old female was admitted due to progressive loss of muscle strength following addition of fluconazole to long-term simvastatin treatment. Rhabdomyolysis was suspected and both drugs were discontinued. Forced diuresis was initiated together with a short course of prednisolone. After 21...

  15. Radiojodbehandling af recidiverende hypertyreose hos patienter som tidligere er behandlet for diffus toksisk struma med subtotal strumektomi

    DEFF Research Database (Denmark)

    Vestergaard, H; Laurberg, P

    1993-01-01

    Radioiodine therapy is often employed for treatment of patients with relapse of hyperthyroidism due to Graves' disease, after previous thyroid surgery. Little is known about the outcome of this treatment compared to patients with no previous surgery. A total of 20 patients, who had received...

  16. Realisering af Vision 2020

    DEFF Research Database (Denmark)

    Bertelsen, Niels Haldor; Hansen, Ernst Jan de Place

    Repræsentanter for byggesektoren har på 11 dialogmøder drøftet Erhvervs- og Byggestyrelsens "Vision 2020 - Byggeri med mening". Drøftelserne førte til formulering af en lang række initiativforslag til realisering af visionen. Den mest centrale udfordring bliver at reducere fejl og mangler i...... byggeriet. Branchen lægger også vægt på, at styringen af Vision 2020s reaisering sker i byggesektoren. Initiativforslagene er i rapporten samlet under 3 hovedområder. Det første hovedområde lægger vægt på bygningerne, brugerbehov og det globale samfund. Det andet omhandler processen og leverancesystemet...

  17. Anvendeligheden af GIS

    DEFF Research Database (Denmark)

    Winstrup, Mie; Levin, Gregor

    2011-01-01

    Fragmentering af naturen er en trussel mod biodiversiteten, og etablering af økologiske forbindelser/korridorer mellem naturområderne er én måde hvorved nedgangen i biodiversitet kan stoppes. Med Næstved Kommune som case-område har jeg undersøgt, hvordan analyser i GIS kan bruges til at udvælge...... omdannet til reelle korridorer, hvor bredden afhænger af arealdækket som forbindelserne krydser. I implementerings øjemed er det anvendeligt at vide om nogle forbindelser er særlig vigtige for at skabe mere sammenhængende natur. GIS er anvendeligt hertil, idet GIS kan bruges til at bestemme den enkelte...

  18. Videoanalyse af social interaktion

    DEFF Research Database (Denmark)

    Igennem de sidste 40 år er videooptagelser af praksis blevet anvendt som et redskab i forskning af social interaktion inden for f.eks. læring, design, mediering, kommunikationstræning og i sundhedsvæsenet. Videoanalyse af social interaktion giver et stærkt metodisk, teoretisk og praktisk blik ind i...... videoanalyse og viser, hvordan man som forsker og studerende kan bruge videoanalyse til at undersøge social interaktion. Bogens temaer og spørgsmål udgør således en grundsten i arbejdet med videoanalyse på professions-, universitets- og forskeruddannelser såvel som i forskning mere generelt og omfatter: - de...

  19. Grebet af sport?

    DEFF Research Database (Denmark)

    Andersen, Tem Frank

    2017-01-01

    I sommeren 1936 blev de Olympiske Lege gennemført i Tyskland. Mediehistorisk var det en begivenhed, fordi det var de første tv-transmitterede Olympiske Lege. Selvom transmissionen kun nåede ud til små biografteatre i de tyske storbyer, så var det noget af en præstation. Over 70 timers sport med de...... fleste af de discipliner, vi kender fra Legene. (...) Uanset hvornår vi daterer sportens begyndelse, så har den haft en dobbelthed. Sport er ikke kun for dem på banen, men også dem på sidelinjerne....

  20. UL-vejledt anlæggelse af fødeepidural hos patient med torakolumbal skoliose

    DEFF Research Database (Denmark)

    Piosik, Zofia Maria; Helbo-Hansen, Søren; Sprehn, Michael

    2015-01-01

    Providing epidural analgesia in patients with scoliosis may be challenging. We describe ultrasound-guided insertion of an epidural catheter for labour analgesia and a following caesarean section in a patient with a thoracolumbar scoliosis. A well-functioning epidural catheter was easily inserted...... on the first attempt without any need for redirections of the epidural needle. Use of ultrasound imaging to guide epidural needle insertion site and trajectory can be a valuable tool in managing patients with scoliosis....

  1. Evaluering af bygningsfornyelse

    DEFF Research Database (Denmark)

    Gottschalk, Georg; Hansen, Jesper Rohr; Jacobsen, Peter Mark

    I 2004 trådte en ny byfornyelseslov i kraft. SBi og Dansk Byplanlaboratorium har evalueret lovens virkemåde i perioden 1.1.2004 -31.12.2006. Denne delrapport fra SBi, AAU drejer sig om bygningsfornyelse, herunder også friarealforbedringer og kondemnering af usunde/brandfarlige beboelsesbygninger...

  2. Anmeldelse af: Gruppepsykologi

    DEFF Research Database (Denmark)

    Christensen, Bodil

    2009-01-01

    , kreativitet og nytænkning. Det er her, videnskabens virkelige fremskridt sker.” Sådan lyder et citat af Albert Einstein, som Lars Svedberg bruger for at sætte sin faglige fremstilling om gruppepsykologi i perspektiv. Gruppeorganisationen er nemlig ofte rum for/ eller kan være rum for denne synergieffekt, der...

  3. Evaluering af naturfaglige kompetencer

    DEFF Research Database (Denmark)

    Dolin, Jens; Nielsen, Jan Alexis

    2017-01-01

    Artiklen skitserer kort de sidste 40-50 års udvikling i naturfagene op til det nuværende fokus på undersøgelsesbaseret undervisning og udvikling af kompetencer. Den påpeger hvorledes mange traditionelle evalueringsformer, især brugt ved eksamen, ikke er i stand til at indfange de ønskede kompeten...

  4. Opfindelsen af naturen

    DEFF Research Database (Denmark)

    Thomsen, Torsten Bøgh

    2016-01-01

    Kritisk omtale og kontekstualisering af Andrea Wulfs, "The Invention of Nature: Alexander von Humboldt’s New World". Der er en direkte forbindelse imellem oplysningstidens naturforståelse og den nuværende klimakrisevirkelighed. Alexander von Humboldt opfandt ikke bare naturen, han påpegede også det...

  5. Digitalisering af undervisning

    DEFF Research Database (Denmark)

    Christiansen, René B.; Hansen, Søren; Rossen, Svend

    2010-01-01

    Rapporten er et bestillingsarbejde fra FU (Forskning og Udvikling) og viser en række eksempler på hvorledes undervisningsforløb kan konstrueres online. Herunder ved brug af både LMS-systemer og web 2.0-værktøjer...

  6. Evaluering af Naturprojektet

    DEFF Research Database (Denmark)

    Westerskov Pedersen, Birgitte; Andkjær, Søren; Støckel, Jan Toftegaard

    Formålet med evalueringen var at belyse, hvordan deltagerne i henholdsvis Furesø og Kerteminde kommune oplevede at deltage i sundheds- og beskæftigelsesprojektet Naturprojektet, samt om de oplevede en forandring i deres fysiske, sociale og mentale helbredstilstand som følge af deres deltagelse i...

  7. Definition af et landdistrikt

    DEFF Research Database (Denmark)

    Søgaard, Villy

    2008-01-01

    Forskellige lande arbejder med meget forskellige definitioner af begrebet landdistrikt. Arbejdspapiret diskuterer først en række generelle krav til definitioner og anbefaler på den baggrund konkrete justeringer i forhold til den hidtidige danske praksis på området. Arbejdspapiret er blevet til i...

  8. På kanten af ungdomslivet

    DEFF Research Database (Denmark)

    Sørensen, Niels Ulrik; Pless, Mette

    2015-01-01

    ). Parallelt hermed fortælles moderne ungdomsliv (i ungdomssociologien) frem gennem ”…theoretical frameworks based on urban experiences which capture neither the lives of rural young people nor the spatial dimensions of the structures and cultures that make up contemporary youth.” (Farrugia 2013......, at yderområder er hårdt ramt af ungdomsarbejdsløshed (Bjørnsted & Andersen 2013), at områderne er præget af høj koncentration af unge med arbejderklassebaggrund (Ottosen et a 2010), mens de uddannelsesorienterede og ressourcestærke unge er tilbøjelige til at flytte væk og ind til byerne (Helve 2003). Og ser man...... stedstilknytning og stedbundne ressourcer. Teoretiske perspektiver, der peger på vigtigheden af en mere ”..spatialised youth sociology that is sensitive to macro-level processes producing different spaces, as well as the local, emplaced ways in which young people are responding to social changest hat shape...

  9. En skygge af modernitet

    DEFF Research Database (Denmark)

    Skov, Christian Egander

    2015-01-01

    Artiklen vil kort skitsere forskellige, samtidige konservative reaktioner på teknikken, hvis destruktive potentiale var blevet åbenbart i og med Første Verdenskrig, og derefter gennem en læsning af Drachmanns politiske og skønlitterære forfatterskab identificere nøgleelementer og begreber i Drach...

  10. Reduktion af stress og sygefravær blandt patienter med arbejdsrelaterede belastnings- og tilpasningsreaktioner henvist til Arbejdsmedicinsk klinik

    DEFF Research Database (Denmark)

    Glasscock, David John; Carstensen, Ole; Dalgaard, Vita Ligaya Ponce

    is plagued by a number of methodological limitations. The definition of study populations is often unclear and there is a lack of studies with patients that have a clinically documented need for treatment. There is also a lack of research that evaluates interventions aimed at both the individual patient...... reactions to stress or adjustment disorders that were work related, patients were offered participation in the project, if inclusion and exclusion criteria were satisfied. Patients answered baseline questionnaires prior to initial examination. The questionnaire, which was used to measure treatment effects......, was repeated again 4 and 10 months after inclusion. Treatment effects were assessed with validated scales: Perceived stress (PSS-10), mental health (GHQ-30), sleep quality (selected items from the BNSQ), and cognitive functioning (two subscales from the CFQ). There were also items concerning sick-leave. After...

  11. Resumé af synkronmaskinens matemaatiske model

    DEFF Research Database (Denmark)

    Leisner, Torben

    1996-01-01

    Afbildning af synkronmaskinens statiske og transiente egenskaber ved hjælp af PARK-transformation.......Afbildning af synkronmaskinens statiske og transiente egenskaber ved hjælp af PARK-transformation....

  12. Anmeldelse af Evolution, Literature and Film

    DEFF Research Database (Denmark)

    Grodal, Torben Kragh

    2011-01-01

    Diskussion af basisproblemer i evolutionær fiktionsteori med udgangspunkt i en anmeldelse af Evolution, Literature and Film......Diskussion af basisproblemer i evolutionær fiktionsteori med udgangspunkt i en anmeldelse af Evolution, Literature and Film...

  13. Udlejers godkendelse af ny erhvervslejer

    DEFF Research Database (Denmark)

    Munk-Hansen, Carsten

    2009-01-01

    I artiklen er taget udgangspunkt i den »klassiske« afståelsessituation, hvor en lejer vil afhænde den i de lejede lokaler drevne virksomhed, og lejeren har afståelsesret til en af udlejer godkendt lejer, uden at kravene til den ny lejer er specificeret. På baggrund af Vestre Landsrets dom af 9/2 ...

  14. Dannelsen af den ansvarlige elev

    DEFF Research Database (Denmark)

    Larsen, Jesper

    2010-01-01

    Denne artikel handler om den del af lærergerningen, der har at gøre med udarbejdelse af elevplaner. Der tages udgangspunkt i en foucaultsk forståelse, hvor beskrivelsen af den enkelte elev udtrykker et særligt normativt ideal om, hvilke former for elevhed der er de ønskværdige i den danske...

  15. En genlæsning af John Rawls i lyset af hans diskussion af forholdet til fremtidige generationer

    DEFF Research Database (Denmark)

    Lübcke, Poul

    2009-01-01

    På grundlag af en konsekventialistisk rekonstruktion af Rawls' politiske position gøres der rede for Rawls eksplicitte og implicitte vurdering af vores ansvar over for fremtidige generationer......På grundlag af en konsekventialistisk rekonstruktion af Rawls' politiske position gøres der rede for Rawls eksplicitte og implicitte vurdering af vores ansvar over for fremtidige generationer...

  16. Selvmonitorering af blodglukose og sygdomsforståelse hos patienter med insulinbehandlet diabetes. Sammenhaeng med metabolisk regulation

    DEFF Research Database (Denmark)

    Wengler, K; Matzen, L E; Sindrup, S

    1989-01-01

    values and planned reduced activity. No connection was observed between the form of treatment, level of regulation or whether the patients undertook self-monitoring and the number of hospital contacts on account of hypoglycaemia or hyperglycaemia. Metabolic regulation was not satisfactory despite self......A questionnaire investigation was undertaken to register the extent to which 212 insulin-treated diabetic patients undertook home measurements of blood glucose and the consequences which they drew from these measurements. This was compared with the metabolic regulation estimated by HbA1c....... The average HbA1c-value was 8.0%. Only 13% had HbA1c-values within the reference range for non-diabetic persons. 85% of the patients undertook self-monitoring of blood glucose. In 47.6% insulin was administered once or twice daily, 42.5% were treated with multiple injections and 9.9% employed insulin pumps...

  17. Ældre patienters oplevelse af selvbestemmelse, når de modtager sygepleje i eget hjem

    DEFF Research Database (Denmark)

    Møller, Annette Fløe; Norlyk, Annelise

    2017-01-01

    of tasks to the nurse, 2) The influence of everyday routines, 3) Resisting or giving up, 4) Having to adapt to a regulating organization. The study concludes that autonomy is embedded in complex power relations at both individual and organizational levels, especially as patients experience both normal...... experiences of autonomy in relation to home care nursing. Based on a phenomenological-hermeneutic approach, six interviews were conducted with patients aged between 77- 88 years. All patients were living at home and dependent on home care nursing. The findings revealed four themes: 1) The handing over...... everyday routines and the nature of the organizational framework itself as overpowering and undermining their autonomy. Keywords: autonomy, self-determination, home care nursing, phenomenological hermeneutic approach....

  18. Retsbeskyttelsen af fostre og befrugtede æg

    DEFF Research Database (Denmark)

    Herrmann, Janne Rothmar

    tydeliggøres og analyseres forskellige problemstillinger: -Abort og fosterreduktion - Fosterdiagnostik - Fosteret som patient og forsøgsperson - Anvendelse af føtale celler og væv - Fosterets status som afdød - Fertilitetsbehandling og sortering af befrugtede æg - Fertilitetsturisme - Stamcelleforskning...

  19. Rivaroxaban versus warfarin in Japanese patients with nonvalvular atrial fibrillation in relation to the CHADS2 score: a subgroup analysis of the J-ROCKET AF trial.

    Science.gov (United States)

    Hori, Masatsugu; Matsumoto, Masayasu; Tanahashi, Norio; Momomura, Shin-Ichi; Uchiyama, Shinichiro; Goto, Shinya; Izumi, Tohru; Koretsune, Yukihiro; Kajikawa, Mariko; Kato, Masaharu; Ueda, Hitoshi; Iekushi, Kazuma; Yamanaka, Satoshi; Tajiri, Masahiro

    2014-02-01

    Results from a trial of rivaroxaban versus warfarin in 1280 Japanese patients with atrial fibrillation (J-ROCKET AF) revealed that rivaroxaban was noninferior to warfarin with respect to the principal safety outcome. In this subanalysis, we investigated the safety and efficacy of rivaroxaban and warfarin in relation to patients' CHADS2 scores. The mean CHADS2 score was 3.25, and the most frequent scores were 3 and 4. No statistically significant interactions were observed between principal safety outcome event rates and CHADS2 scores with respect to treatment groups (P value for interaction = .700). Irrespective of stratification into moderate- and high-risk groups based on CHADS2 scores of 2 and 3 or more, respectively, no differences in principal safety outcome event rates were observed between rivaroxaban- and warfarin-treated patients (moderate-risk group: hazard ratio [HR], 1.06; 95% confidence interval [CI], .58-1.95; high-risk group: HR, 1.11; 95% CI, .86-1.45; P value for interaction = .488). The primary efficacy end point rate in the rivaroxaban-treated group was numerically lower than in the warfarin-treated group, regardless of risk group stratification (moderate-risk group: HR, .46; 95% CI, .09-2.37; high-risk group: HR, .49; 95% CI, .22-1.11; P value for interaction = .935). This subanalysis indicated that the safety and efficacy of rivaroxaban compared with warfarin were similar, regardless of CHADS2 score. Copyright © 2014 National Stroke Association. Published by Elsevier Inc. All rights reserved.

  20. Risk factoRs foR death in hiV-infected adult afRican patients ...

    African Journals Online (AJOL)

    2010-11-11

    Nov 11, 2010 ... their urban counterparts, most of who live close to the hospital. another possible explanation for the mortality differences is differential reporting. Because the rural communities are smaller and have much closer ties to the health centre staff than do urban patients with MtRh staff, it is possible that deaths are.

  1. Patienters oplevelse af at indgå i sammedagsforløb ved operation for diskusprolaps og spinalstenose

    DEFF Research Database (Denmark)

    Gryet, Inger Markussen; Rasmussen, Bodil Tornbjerg

    , health care personal and from knowledge about the advantage of fast track pathways. Moreover it is a political strategy in the Danish health care system to enhance effectivity. Before implementing it as a standard, we wanted to investigate how the patients experience the shorten pathways. Objectives...

  2. Contemporary Antithrombotic Treatment in Patients with Non-valvular Atrial Fibrillation Undergoing Percutaneous Coronary Intervention: Rationale and Design of the Greek AntiPlatElet Atrial Fibrillation (GRAPE-AF) Registry.

    Science.gov (United States)

    Xanthopoulou, Ioanna; Dragona, Vasiliki-Maria; Davlouros, Periklis; Tsioufis, Costas; Iliodromitis, Efstathios; Alexopoulos, Dimitrios

    2018-04-20

    Approximately 5 to 7% of patients undergoing percutaneous coronary intervention (PCI) for the treatment of coronary artery disease require chronic oral anticoagulation (OAC) on top of aspirin and a P2Y 12 receptor antagonist, mainly due to non-valvular atrial fibrillation (AF). The advent of non-vitamin K antagonist oral anticoagulants (NOACs) increased treatment options, while there is cumulative evidence that dual combination of a NOAC and a P2Y 12 receptor antagonist attenuates risk of bleeding, compared to traditional triple therapy, consisting of a vitamin K antagonist (VKA), aspirin, and a P2Y 12 receptor antagonist, without significantly compromising efficacy. Greek AntiPlatElet Atrial Fibrillation (GRAPE-AF, NCT 03362788) is an observational, nationwide study of non-valvular AF patients undergoing PCI, planning to enroll over 1-year period > 500 participants in 25 tertiary and non-tertiary PCI centers in Greece. Key data to be collected pre-discharge include demographics, detailed past medical history, and antithrombotic and concomitant treatment. Patients will be followed up at 1, 6, and 12 months post hospital discharge. Αt each follow-up visit, data on antithrombotic treatment, ischemic, bleeding, and adverse events will be collected. Study's primary endpoint is clinically significant bleeding (Bleeding Academic Research Consortium, BARC ≥ 2) at 12 months, between VKAs and NOACs-treated patients, analyzed using Cox proportional hazards models, by an intention-to-treat principle. An independent endpoint committee will adjudicate all clinical events. This study aims at providing "real-world" information on current antithrombotic treatment patterns and clinical outcome of patients with non-valvular AF undergoing PCI.

  3. Nedtrykt af negative nyheder

    DEFF Research Database (Denmark)

    Skovsgaard, Morten; Søberg, Pernille Frantz

    2016-01-01

    I adskillige år er det blevet debatteret, hvorvidt nyhedernes negative fokus har konsekvenser for borgerne, og om det i sid-ste ende får flere til at vende ryggen til nyhederne. Vores viden om effekterne af positive og negative nyheder er dog begrænset, og derfor undersøges det i denne artikel......, hvordan henholdsvis positive og negative tv-nyheder påvirker seernes humør, hukom-melse af information fra indslaget og lyst til at se yderligere tv-nyheder. Det gør vi i et survey-eksperiment (N=204), hvor tre grupper så enten et originalt indslag eller det samme indslag klippet med henholdsvis et...

  4. Diagnostik og behandling af sjældne årsager til iskæmisk apopleksi

    DEFF Research Database (Denmark)

    Kondziella, Daniel

    2016-01-01

    require sophisticated diagnostics (e.g. fluorescence angiography in Susac's syndrome) and they are increasingly treatable (e.g. enzyme replacement for Fabry's disease). This review discusses practical considerations and recent diagnostic and therapeutic advances in uncommon causes of ischaemic stroke.......Rare causes of ischaemic stroke comprise a plethora of diagnoses of cardioembolic, inflammatory and genetic origin. The differential diagnosis is challenging but important because these disorders (e.g. monogenetic disorders such as COL4A1 mutations) often affect young individuals, they typically...

  5. Behandling af diabetisk ketoacidose hos voksne på medicinske afdelinger i Danmark. Behov for nationale retningslinjer?

    DEFF Research Database (Denmark)

    Henriksen, Otto Mølby; Røder, Michael Einar; Svendsen, Ole Lander

    2007-01-01

    This study examines variations in treatment routines for diabetic ketoacidosis (DKA) in Denmark. All departments of internal medicine in Denmark managing DKA were invited to complete a questionnaire. 88% replied. The study shows significant variations in management routines of DKA in Denmark...

  6. Heterotop graviditet efter IVF-behandling med excision af rumperet interstitiel graviditet og senere kejsersnit nær termin

    DEFF Research Database (Denmark)

    Elers, Jimmi; Zingenberg, Helle; Bing, Mette Hornum

    2017-01-01

    We describe a rare case of heterotopic pregnancy following in vitro fertilization with transferring of two embryos in a 39-year-old woman with previous bilateral salpingectomy. An ultrasound examination was performed on the day before admission showing a vital intrauterine pregnancy and no ectopic...... pregnancy. The woman was admitted with a ruptured cornual pregnancy at ten weeks of gestation. Laparotomy was performed on vital indication with excision of the ruptured haemorrhagic cornual pregnancy. The intrauterine pregnancy continued uneventfully with obstetric and fetal medicine specialist monitoring...

  7. Heterotop graviditet efter IVF-behandling med excision af rumperet interstitiel graviditet og senere kejsersnit nær termin

    DEFF Research Database (Denmark)

    Elers, Jimmi; Zingenberg, Helle; Bing, Mette H

    2016-01-01

    We describe a rare case of heterotopic pregnancy following in vitro fertilization with transferring of two embryos in a 39-year-old woman with previous bilateral salpingectomy. An ultrasound examination was performed on the day before admission showing a vital intrauterine pregnancy and no ectopic...... pregnancy. The woman was admitted with a ruptured cornual pregnancy at ten weeks of gestation. Laparotomy was performed on vital indication with excision of the ruptured haemorrhagic cornual pregnancy. The intrauterine pregnancy continued uneventfully with obstetric and fetal medicine specialist monitoring...

  8. Optisk kvantificering af gopler

    DEFF Research Database (Denmark)

    Christensen, Jens Tang

    efterfølgende med specielt udviklet software, med henblik på arts-, størrelses- og antalsfordeling. Indledende tests har vist, at mens Aurelia og Cyanea nemt registreres i lysgardinet, idet de lyser kraftigt op, er brydningsindekset for små individer af Mnemiopsis så tæt på vand, at der kræves stor kontrast på...

  9. På sporet af sprogpsykologi

    DEFF Research Database (Denmark)

    2005-01-01

    Sprogpsykologi beskæftiger sig med, hvordan sprog og mennesker hænger sammen, og hvilke følger sammenhængen får for vore forståelser af verden og os selv. Denne antologi henvender sig til den sproginteresserede, der ønsker at gå et lag dybere end sprogets grammatiske sider. Sprog er ikke kun et l...

  10. Hvordan integration af it?

    DEFF Research Database (Denmark)

    Toft, Herdis

    2008-01-01

    Fokus i artiklen er den måde, hvorpå børn positionerer sig på i skolerummet, og på, hvordan børn gennem brug af it opbygger og integrerer digital kompetence forstået som færdigheder, kundskaber og holdninger, der skal sætte dem i stand til at agere i det lærende samfund. Med udgangspunkt i et Bou...

  11. Innovation af innovation

    DEFF Research Database (Denmark)

    Harste, Gorm

    2009-01-01

    , at innovation af innovationen forsøges gennemført på en måde, hvor tiden kræves at forholde sig til sin egen tidslighed i form af fremtid, nutid, fortid og ikke mindst i form af samtidighed. I tiden skal vi iagttage, hvordan vi iagttager tiden. Vi dobbelt-koder tiden på samme måde, som forskning forsker i...... organisationssystemerne. De to typer systemer kan noget helt bestemt med fænomenet tid. De kan synkronisere. Analyseres organisationssystemer ser vi, imidlertid at innovation kræver ro. Stærkt innovative systemer er militærsystemet og kunstsystemet, der også inddrages, og hvor vi ser paradokset mellem innovation og...... involution. Tid er med et medium og ikke et lufttomt rum. Tid er end ikke en gasart, men udgør et solidt fluidum, som samfundet bader i og flyder i, konstant i bevægelse. Reformer forudsætter former, og innovation forudsætter involution. Kun sådan muliggøres evolution....

  12. Anvendelser af Pervasive Communication

    DEFF Research Database (Denmark)

    Brønsted, Jeppe

    I øjeblikket er den måde, vi kommunikerer på, ved at ændre sig drastisk. Fra at vi for få år siden var nødt til at nøjes med Internetkommunikation mellem stationære computere, forbindes en masse nye typer af enheder i dag på nye måder. Da vi nu ikke længere er bundet til en computer, der ikke kan...... flytte sig, bliver en masse nye ting mulige, fordi vi er forbundet med omverdenen i enhver kontekst. Da vi traditionelt ikke tænker i at være forbundet altid overalt er det ikke let at se, hvordan dette nye paradigme påvirker os i vores hverdag og hvordan vi kan udnytte det til nye forretnings- og...... forskningsmuligheder. For at gøre det hele lidt mere konkret, præsenteres i dette dokument en række eksempler på brug af Pervasive Communication. Udvalget af eksempler skal ikke ses som værende udtømmende, men snarere som håndplukkede eksempler der hver repræsenterer en genre. I dokumentet er både valgt...

  13. Medical cost reductions associated with the usage of novel oral anticoagulants vs warfarin among atrial fibrillation patients, based on the RE-LY, ROCKET-AF, and ARISTOTLE trials.

    Science.gov (United States)

    Deitelzweig, Steve; Amin, Alpesh; Jing, Yonghua; Makenbaeva, Dinara; Wiederkehr, Daniel; Lin, Jay; Graham, John

    2012-01-01

    The randomized clinical trials, RE-LY, ROCKET-AF, and ARISTOTLE, demonstrate that the novel oral anticoagulants (NOACs) are effective options for stroke prevention among non-valvular atrial fibrillation (AF) patients. This study aimed to evaluate the medical cost reductions associated with the use of individual NOACs instead of warfarin from the US payer perspective. Rates for efficacy and safety clinical events for warfarin were estimated as the weighted averages from the RE-LY, ROCKET-AF and ARISTOTLE trials, and event rates for NOACs were determined by applying trial hazard ratios or relative risk ratios to such weighted averages. Incremental medical costs to a US health payer of an AF patient experiencing a clinical event during 1 year following the event were obtained from published literature and inflation adjusted to 2010 cost levels. Medical costs, excluding drug costs, were evaluated and compared for each NOAC vs warfarin. Sensitivity analyses were conducted to determine the influence of variations in clinical event rates and incremental costs on the medical cost reduction. In a patient year, the medical cost reduction associated with NOAC usage instead of warfarin was estimated to be -$179, -$89, and -$485 for dabigatran, rivaroxaban, and apixaban, respectively. When clinical event rates and costs were allowed to vary simultaneously, through a Monte Carlo simulation, the 95% confidence interval of annual medical costs differences ranged between -$424 and +$71 for dabigatran, -$301 and +$135 for rivaroxaban, and -$741 and -$252 for apixaban, with a negative number indicating a cost reduction. Of the 10,000 Monte-Carlo iterations 92.6%, 79.8%, and 100.0% were associated with a medical cost reduction >$0 for dabigatran, rivaroxaban, and apixaban, respectively. Usage of the NOACs, dabigatran, rivaroxaban, and apixaban may be associated with lower medical (excluding drug costs) costs relative to warfarin, with apixaban having the most substantial medical cost

  14. Kulturelle spejlinger af Profeten Muhammed

    DEFF Research Database (Denmark)

    Høgsbro Lading, Åse

    2008-01-01

    Artiklen er en analyse af to forløb i den såkaldte Muhammedkrise, der udspringer af Jyllandspostens offentliggørelse af karrikaturer af profeten Muhammed. Den første i 2006 ses som et  udspil, der først og frememst er styret  af markedsmæssige interesser, og hvor de globale reaktioner kom bag på...... forsvar opleves  af avisen i splitting-kategorier: enten kan man sige alt, eller også har man ikke ytringsfrihed. Artiklen slutter med et ønske om, at mere komplekse syn på de globale relationer kan etableres...

  15. Rating af banker og banksystemer

    DEFF Research Database (Denmark)

    Grosen, Anders

    2010-01-01

    Banksystemer over hele verdenen er med nød og næppe blevet reddet af diverse statslige hjælpepakker. Derfor er der i disse år øget fokus på banker og banksystemers rating. Denne interesse bliver ikke mindre af, at de statslige garantier til bankerne i mange lande udløber i de kommende år. Rating af...

  16. Energiforbrug til opvarmning af bygninger

    DEFF Research Database (Denmark)

    Budde, J.; Pedersen, D.O.

    Rapporten giver oplysninger om enhedsforbrug til varme og varmt brugsvand i forskellige typer af bygninger baseret på en analyse af et omfattende datamateriale. Formålet med undersøgelsen har været at ajourføre denne del af grundlaget for både landsdækkende og lokal varmeplanlægning i Danmark....

  17. Clinical presentation, management, and outcomes in the Indian Heart Rhythm Society-Atrial Fibrillation (IHRS-AF registry

    Directory of Open Access Journals (Sweden)

    A. Vora

    2017-01-01

    Conclusions: In India, AF patients are younger and RHD is still the most frequent etiology. Almost two-third of the patients have persistent/permanent AF. At one-year follow-up, there is a significant mortality and morbidity in AF patients in India.

  18. PET-scanninger af hjernen

    DEFF Research Database (Denmark)

    Alstrup, Aage Kristian Olsen; Aanerud, Joel Fredrik Astrup

    2017-01-01

    PET-skanninger bruges i stigende grad til at diagnosticere hjernetumorer og neurodegenerative lidelser hos mennesker. Nogle af disse metoder vil potentelt også kunne finde veterinær anvendelse i de kommende år til diagnostik af hjernelidelser hos hos kæledyr.......PET-skanninger bruges i stigende grad til at diagnosticere hjernetumorer og neurodegenerative lidelser hos mennesker. Nogle af disse metoder vil potentelt også kunne finde veterinær anvendelse i de kommende år til diagnostik af hjernelidelser hos hos kæledyr....

  19. Udvidelse af National Gallery London

    DEFF Research Database (Denmark)

    Svendler Nielsen, Hans Peter

    1987-01-01

    Grundig gennemgang af The Venturis projekt til udvidelse af National Gallery i London, den såkaldte Sainsbury Wing, med en indledning om den amerikanske tegnestues øvrige europæiske projekter: Frankfurts kunsthåndværkermuseum og Ponte dell' Accademia i Venezia.......Grundig gennemgang af The Venturis projekt til udvidelse af National Gallery i London, den såkaldte Sainsbury Wing, med en indledning om den amerikanske tegnestues øvrige europæiske projekter: Frankfurts kunsthåndværkermuseum og Ponte dell' Accademia i Venezia....

  20. Kontrol af patienter med levertraumer

    DEFF Research Database (Denmark)

    Osterballe, Lene; Helgstrand, Frederik; Hillingsø, Jens

    2014-01-01

    Development of a hepatic pseudoaneurysm (HPA) is a well-known, yet rare complication after liver trauma. We found 135 cases reported in the literature since 1965. Ruptured HPAs may have severe consequences with sudden massive haemorrhage and death. A clear strategy towards diagnosis and management...... of HPA post liver trauma is needed and outlined in this paper. We recommend early detection and definitive treatment before enlargement and rupture....