Sample records for beginning of human life

  1. The beginning of human life (United States)


    Introduction The Jewish religion is characterized by a strict association between faith and practical precept. Jewish law has two sections, the written and the oral tradition. The foundation of the written law and the origin of authority is the Torah, the first five books of the Scripture. It is an expression of God’s revelation, teaching and guiding humanity. The oral laws interpret, expand, and elucidate the written Torah and behavior patterns regulate new rules and customs. The main parts of the oral law are as follows: the Mishnah, the Talmud, Post-Talmudic Codes and. Responsa Literature. Discussion Life is a process that has a beginning and an end. The consensus about the time when human life really begins is still not reached among scientists, philosophers, ethicists, sociologists and theologizes. The scientific data suggested that a single developmental moment marking the beginning of human life does not exist. Current biological perspectives on when human life begins range through fertilization, gastrulation, to birth and even after. The development of a newborn is a smoothly continuous process. Results Procreation is acknowledged in the Bible to be the gift of God. The (Halachic) Jewish interpretation of when human life begins is extracted predominantly from procreation is acknowledged in the Bible to be the gift of God. The Jewish interpretation of when human life begins is extracted predominantly from The Halachic sources. The Bible does not make any other direct references regarding the beginning of human life. Conclusion While the Talmud gives the full status of humanness to a child at birth, the rabbinical writings have partially extended the acquisition of humanness to the 13th postnatal day of life for full-term infants. The Babylonian Talmud Yevamot 69b states that: “the embryo is considered to be mere water until the fortieth day.” Afterwards, it is considered subhuman until it is born. The issues of abortion, embryo research, multifetal

  2. The beginning of human life : status of embryo. Perspectives in Halakha (Jewish Religious Law). (United States)

    Schenker, Joseph G


    The Jewish religion is characterized by a strict association between faith and practical precept. Jewish law has two sections, the written and the oral tradition. The foundation of the written law and the origin of authority is the Torah, the first five books of the Scripture. It is an expression of God's revelation, teaching and guiding humanity. The oral laws interpret, expand, and elucidate the written Torah and behavior patterns regulate new rules and customs. The main parts of the oral law are as follows: the Mishnah, the Talmud, Post-Talmudic Codes and. Responsa Literature. Life is a process that has a beginning and an end. The consensus about the time when human life really begins is still not reached among scientists, philosophers, ethicists, sociologists and theologizes. The scientific data suggested that a single developmental moment marking the beginning of human life does not exist. Current biological perspectives on when human life begins range through fertilization, gastrulation, to birth and even after. The development of a newborn is a smoothly continuous process. Procreation is acknowledged in the Bible to be the gift of God. The (Halachic) Jewish interpretation of when human life begins is extracted predominantly from procreation is acknowledged in the Bible to be the gift of God. The Jewish interpretation of when human life begins is extracted predominantly from The Halachic sources. The Bible does not make any other direct references regarding the beginning of human life. While the Talmud gives the full status of humanness to a child at birth, the rabbinical writings have partially extended the acquisition of humanness to the 13th postnatal day of life for full-term infants. The Babylonian Talmud Yevamot 69b states that: "the embryo is considered to be mere water until the fortieth day." Afterwards, it is considered subhuman until it is born. The issues of abortion, embryo research, multifetal reduction and cloning will be discussed according to

  3. [The beginning of human life: ethical and legal perspectives in the context of biotechnological progress]. (United States)

    Barretto, Vicente de Paulo; Lauxen, Elis Cristina Uhry


    Questions concerning the beginning of human life have pervaded society since antiquity. In the post-modern world, scientific and technological advances have fueled discussions on the issue, such that debates previously concentrated on abortion now also focus on biotechnological interventions. The article addresses the latter, reflecting on the extent to which human dignity can be considered a (hermeneutic) reference in establishing ethical and legal parameters for biotechnological advances in the definition of the beginning of human life. The study's method was critical hermeneutic ethics, with ethics at the center of the process of understanding and interpretation, observing the contours of facticity. No consensus was found on the beginning of human life, so it is essential to engage in dialogue with the new reality resulting from biotechnological advances in the process of defining ethical and legal principles for protecting the embryo and human nature, with human dignity as the reference.

  4. Bidrag til "Life begins at 100 - Secrets of the supercentenarians"

    DEFF Research Database (Denmark)

    von Bornemann Hjelmborg, Jacob


    Bidrag til: "Life begins at 100 - Secrets of the supercentenarians". Uddrag fra Human Genetics, vol. 119 p 1432. Udgivelsesdato: 5 september......Bidrag til: "Life begins at 100 - Secrets of the supercentenarians". Uddrag fra Human Genetics, vol. 119 p 1432. Udgivelsesdato: 5 september...

  5. Structure and dynamics of human communication at the beginning of life. (United States)

    Papousek, H; Papousek, M


    Although the beginning of postpartum social integration and communication has been long viewed as relevant to psychiatric theories, early parent-infant communication has become a matter of scientific investigation only recently. The present survey explains the significance of an approach based upon the general systems theory and explores to what extent the early parent-infant interaction can function as a didactic system to support the development of thought and speech. Evidence of this function has been found in those forms of parental behavior that escape the parent's conscious awareness and control, as exemplified in the vocal communication with presyllabic infants. Parents unknowingly adjust the structure and dynamics of speech to the constraints of infant capacities, detach prosodic musicality from lexical structure, and use it in particularly expressive forms for the delivery of the first prototypical messages. In this and other similar ways, parents offer an abundance of learning situations in which infants can try out various integrative operations. A biological rather than cultural provenience of the support of communicative development indicates a potential relevance for the interpretation of speech evolution. In addition to qualities of the vocal tract and to complex symbolic capacities in humans, the early intuitive support of communicative development and its playful character are suggested as species-specific determinants of speech evolution. Implications for clinical research are suggested.

  6. The Needs of Humans: A Beginning (United States)

    Scott, Marie


    This article focuses on a teaching method developed by Maria Montessori, starting with activities in the primary classroom, which are continued through the elementary years. The author discusses a few child-centered techniques in preparing children for their work within a larger community--the whole human family. In the Montessori environment, the…

  7. Life begins at 40

    International Nuclear Information System (INIS)

    Neal, L.


    A new rule makes nuclear power plant license renewal a viable option. A small group of corporate executives will soon face one of the toughest decisions of their careers-a decision that will affect 17 million American homes. Forty-five commercial nuclear power plants will reach the end of their operating licenses early in the next century. They represent billions of dollars in capital investment, and the companies that own them must decide whether to keep them on the grid or scrap them. But before a company decides whether to pull the plug on a big generating plant, it will have to do some homework. Company executives will have to roll up their sleeves and dig deep into projections of electricity demand, assessments of generating options and cold, hard economics. At the same time, they must keep wary eyes on the political landscape, scanning ahead for roadblocks and quicksand

  8. Mediation Approaches at the Beginning or End of Life. (United States)

    Howe, Edmund G


    The approaches used in mediation may help ethics consultants, especially in difficult cases. In this piece, I primarily discuss these techniques. I also discuss how clinicians may be of the most help to parents of infants with severe genetic conditions, to research participants, and to patients who may be at risk for Alzheimer's disease and their surrogate decision makers. Copyright 2015 The Journal of Clinical Ethics. All rights reserved.

  9. Bootstrapping the energy flow in the beginning of life.

    NARCIS (Netherlands)

    Hengeveld, R.; Fedonkin, M.A.


    This paper suggests that the energy flow on which all living structures depend only started up slowly, the low-energy, initial phase starting up a second, slightly more energetic phase, and so on. In this way, the build up of the energy flow follows a bootstrapping process similar to that found in

  10. Bootstrapping the energy flow in the beginning of life

    NARCIS (Netherlands)

    Hengeveld, R.; Fedonkin, M.A.


    This paper suggests that the energy flow on which all living structures depend only started up slowly, the low-energy, initial phase starting up a second, slightly more energetic phase, and so on. In this way, the build up of the energy flow follows a bootstrapping process similar to that found in

  11. Where/when/how did life begin? A philosophical key for systematizing theories on the origin of life (United States)

    Świeżyński, Adam


    The question of the origin of life interested people for centuries. All existing views on this subject can be classified into different areas of human knowledge about the world: natural sciences, philosophy, and theology (religion). It is interesting to look at them closer and to classify all the typical groups of the theories about the origins of life. We can then see links existing between them and relationships that indicate their own nature. Nowadays, driving forces of prebiological chemical evolution and the mode of explanation of the transition 'non-life into life' give a great variety of solutions. The differences between the theories, however, as well as the current controversies in the scientific community (what 'in the beginning' was?; where and when the prebiotic evolution may took place? etc.) will be shown as of secondary importance for the theories' systematization in comparison with several much more profound philosophical assumptions underlying the origin-of-life-studies. My proposal to organize and classify different types of the theories of genesis of life allows for extracting conceptions of different kind: metaphysical and scientific, and also for comparing them with each other. Some of them answer the question of the emergence of life in general and others on the question of the origin of life on the Earth only. In the perspective of contemporary scientific research on the origin of life it seems interesting that two main ideas concerning the problem of the origin of life, spontaneous generation and panspermia, are still present as presuppositions of certain theories but have been modified. Thus a 'philosophical key' seems to be the most appropriate to systematize all kinds of theories on the origin of life. This paper is an attempt to justify the position adopted. Most important conclusion is that the philosophical basis or implications, which are irreducibly present and possible to be found within the scientific theories of the origin of life

  12. [The human meaning of life]. (United States)

    Lejeune, J


    Technical development has produced a curious phenomenon, the ebbing of the moral imperative of reproduction. After 2000 years of fight against diseases and death, the respect for life has declined threatening the destruction of Western civilization and family by destroying unborn babies via abortion. Artificial in vitro experimentation can potentially lead to elimination of very young, old, or sick people. Dr. Bernard Nathanson in his book "Aborting America" called abortion infanticide, one of the most abominable crimes. The beginning of life start at conception as shown by recent extra-corporal, in vitro fertilization resulting in a viable fetus, as in the case of Luisa Brown who was conceived in a tube by Drs. Edwards' and Steptoe's technique. The creation of human embryo banks and experimentation on human embryos amount to biological pronography. Respect for the human species and reproduction should manifest itself in the fight against sterility and genetic diseases, such as muscular dystrophy, hemophilia, Down's syndrome, and Huntington's chorea. The fight against AIDS and the elimination of the risk of contracting it by contaminated blood is also a medical priority. In the end, the question still remains: can science itself save the world without moral imperatives, is not the dilemma of Faust and the vileness of Mephistopheles conjured with the nuclear experience and human experimentation.

  13. The beginnings of human palaeontology: prehistory, craniometry and the 'fossil human races'. (United States)

    Goodrum, Matthew R


    Since the nineteenth century, hominid palaeontology has offered critical information about prehistoric humans and evidence for human evolution. Human fossils discovered at a time when there was growing agreement that humans existed during the Ice Age became especially significant but also controversial. This paper argues that the techniques used to study human fossils from the 1850s to the 1870s and the way that these specimens were interpreted owed much to the anthropological examination of Stone, Bronze, and Iron Age skeletons retrieved by archaeologists from prehistoric tombs throughout Europe. What emerged was the idea that a succession of distinct human races, which were identified using techniques such as craniometry, had occupied and migrated into Europe beginning in the Ice Age and continuing into the historic period. This marks a phase in the history of human palaeontology that gradually gave way to a science of palaeoanthropology that viewed hominid fossils more from the perspective of evolutionary theory and hominid phylogeny.

  14. Emergency Contraceptives and the Beginning of Human Animals. (United States)

    Paez, Eze


    Emergency contraceptives may sometimes prevent implantation, thereby causing the death of the embryo. According to some positions contrary to abortion, because the embryo is a human animal, there are usually decisive moral reasons not to use them. In this article, I will show that objecting to the use of emergency contraceptives on those grounds is unjustified. If organisms are real existents, then according to the most plausible conception of what is required for a group of cells to compose one, the embryo cannot qualify as a single organism. On the other hand, if organisms are virtual objects, then whether or not the embryo qualifies as one is morally irrelevant. I conclude that even if those positions are right about the morality of abortion, they are not entitled to oppose the use of emergency contraceptives. © 2016 John Wiley & Sons Ltd.

  15. The beginning and the end the meaning of life in a cosmological perspective

    CERN Document Server

    Vidal, Clément


    In this fascinating journey to the edge of science, Vidal takes on big philosophical questions: Does our universe have a beginning and an end or is it cyclic? Are we alone in the universe? What is the role of intelligent life, if any, in cosmic evolution? Grounded in science and committed to philosophical rigor, this book presents an evolutionary worldview where the rise of intelligent life is not an accident, but may well be the key to unlocking the universe's deepest mysteries. Vidal shows how the fine-tuning controversy can be advanced with computer simulations. He also explores whether nat

  16. Benchmarking of NESTLE against measured PWR data at beginning of life

    International Nuclear Information System (INIS)

    Mosteller, R.D.


    The NESTLE advanced nodal code was developed at North Carolina State University with support from Los Alamos National Laboratory and Idaho National Engineering Laboratory. This paper presents the first comparisons of NESTLE predictions with measured data from pressurized water reactors (PWRs). Specifically, NESTLE predictions for critical soluble boron concentrations and isothermal temperature coefficients (ITCs) of reactivity are compared with beginning-of-life (BOL) measurements from four PWRs. All of those measurements were made at hot-zero-power (HZP) conditions prior to ascension to power

  17. Participative Facility Planning for Obstetrical and Neonatal Care Processes: Beginning of Life Process

    Directory of Open Access Journals (Sweden)

    Jori Reijula


    Full Text Available Introduction. Old hospitals may promote inefficient patient care processes and safety. A new, functionally planned hospital presents a chance to create an environment that supports streamlined, patient-centered healthcare processes and adapts to users’ needs. This study depicts the phases of a facility planning project for pregnant women and newborn care processes (beginning of life process at Turku University Hospital. Materials and Methods. Project design reports and meeting documents were utilized to assess the beginning of life process as well as the work processes of the Women’s and Children’s Hospital. Results. The main elements of the facility design (FD project included rigorous preparation for the FD phase, functional planning throughout the FD process, and setting key values: (1 family-centered care, (2 Lean thinking and Lean tools as the framework for the FD process, (3 safety, and (4 cooperation. Conclusions. A well-prepared FD project with sufficient insight into functional planning, Lean thinking, and user-centricity seemed to facilitate the actual FD process. Although challenges occurred, the key values were not forgone and were successfully incorporated into the new hospital building.

  18. [Construction vs. development: the source of our misunderstandings concerning the beginning of life]. (United States)

    Stith, Richard


    This essay argues that the failure of our public debates over abortion and embryo-destructive research is due, to a large extent, not to different valuation of individual human life but to different conceptions and intuitions concerning the process of gestation, one group treating the process as construction and another treating it as development. These two incompatible models of reproduction are shown to explain the various positions commonly encountered in these life-related debates. Finally, the historical, theoretical, and intuitive strengths of each model are examined.

  19. Symposium: A Beginning in the Humanities (United States)

    Brooks, Peter; Fry, Paul H.; Carnochan, W. B.; Culler, Jonathan; Lerer, Seth; Marshall, Donald G.; Johnson, Barbara; Steiner, Wendy; Haack, Susan; Nussbaum, Martha C.


    2001 marked Yale's 300th birthday. It seemed an opportunity for reflection on the evolution of the institution, and particularly on the vicissitudes of the humanities over those three centuries. This article presents essays which represent a selection from the symposium, "Beginning With the Humanities," held at the Whitney Humanities Center on…

  20. Ethics teaching on 'Beginning of Life' issues in UK medical schools. (United States)

    Oldroyd, Christopher; Fialova, Lydie


    Medical ethics forms an essential component of an undergraduate medical programme. In the UK the Institute of Medical Ethics has released a consensus statement detailing its recommendations for a minimum curriculum for ethics. One important issue it highlights for inclusion is 'Beginning of Life', which includes a wide range of themes. This paper presents an evaluation of the current teaching and assessment of these important issues in UK medical schools, complemented by a specific analysis of students' reaction to the teaching they received at the University of Edinburgh as part of their Obstetrics and Gynaecology rotation. Schools which responded to the survey reported a wide range of teaching and assessment methods. While there was a good overall coverage of topics, only one of them was covered by every institution and the religious/cultural elements of those topics were often neglected. The medical schools viewed better clinical integration of ethics teaching as the best route to improvement, but the students reported a desire for more ethics teaching in the form of specific tutorials, lectures or discussions. It is likely that a combination of these approaches will lead to significant improvements in the delivery of ethics teaching in this area and in others. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to

  1. Human rights begin at birth: international law and the claim of fetal rights. (United States)

    Copelon, Rhonda; Zampas, Christina; Brusie, Elizabeth; Devore, Jacqueline


    In the Universal Declaration of Human Rights, the foundation of human rights, the text and negotiating history of the "right to life" explicitly premises human rights on birth. Likewise, other international and regional human rights treaties, as drafted and/or subsequently interpreted, clearly reject claims that human rights should attach from conception or any time before birth. They also recognise that women's right to life and other human rights are at stake where restrictive abortion laws are in place. This paper reviews the International Covenant on Civil and Political Rights, the Convention on the Rights of the Child, and the Convention on the Elimination of All Forms of Discrimination Against Women, the European Convention for the Protection of Human Rights and Fundamental Freedoms, the Inter-American Human Rights Agreements and African Charter on Human and People's Rights in this regard. No one has the right to subordinate another in the way that unwanted pregnancy subordinates a woman by requiring her to risk her own health and life to save her own child. Thus, the long-standing insistence of women upon voluntary motherhood is a demand for minimal control over one's destiny as a human being. From a human rights perspective, to depart from voluntary motherhood would impose upon women an extreme form of discrimination and forced labour.

  2. The development of the temporal macrostructure of life narratives across adolescence: beginnings, linear narrative form, and endings. (United States)

    Habermas, Tilmann; Ehlert-Lerche, Silvia; de Silveira, Cybèle


    The ontogeny of the ability to describe people culminates in adolescence in the development of the life story. An overarching temporal macrostructure and framing by a prehistory and a future-oriented global evaluation of life helps integrate disparate autobiographical memories into a coherent story. Two life narratives each of 8-, 12-, 16-, and 20-year-olds (N=102) were analyzed in terms of how well-formed their beginnings and endings are and how much they follow a linear temporal order. By age 12, the majority of life narratives began with birth, ended in the present, and followed a chronological order. In late adolescence and early adulthood, more elaborate birth narratives and retrospective evaluations of life and outlooks into the future were added. These formal characteristics were related to biographical practices, biographical knowledge, and fluid intelligence. Text-analytical methods are proposed as a method for the analysis of biographical and autobiographical reasoning and understanding.

  3. Prevention of late-life Depression in Primary Care: Do we know where to begin?

    NARCIS (Netherlands)

    Schoevers, R.; Smit, H.F.E.; Deeg, D.J.H.; Cuijpers, P.; Dekker, J.J.M.; van Tilburg, W.; Beekman, A.J.


    OBJECTIVE: This study attempted to compare two models for selective (people at elevated risk) and indicated (those with subsyndromal depressive symptoms) prevention and to determine the optimal strategy for prevention of late-life depression. METHOD: Onset was assessed at 3 years with the Geriatric

  4. Life Begins at Thirty: Training and Employment Opportunities in the Psychology of Aging (United States)

    Fozard, James L.


    Possibilities for employment opportunities related to aging are reviewed for four areas of professional psychology: clinical and counseling psychology, education, human factors engineering and ecological psychology, and teaching research. Some reasons for the slow development of opportunities for employment in the field of psychology of aging are…

  5. Quality of Life Theory II. Quality of Life as the Realization of Life Potential: A Biological Theory of Human Being

    Directory of Open Access Journals (Sweden)

    Soren Ventegodt


    Full Text Available This review presents one of the eight theories of the quality of life (QOL used for making the SEQOL (self-evaluation of quality of life questionnaire or the quality of life as realizing life potential. This theory is strongly inspired by Maslow and the review furthermore serves as an example on how to fulfill the demand for an overall theory of life (or philosophy of life, which we believe is necessary for global and generic quality-of-life research.Whereas traditional medical science has often been inspired by mechanical models in its attempts to understand human beings, this theory takes an explicitly biological starting point. The purpose is to take a close view of life as a unique entity, which mechanical models are unable to do. This means that things considered to be beyond the individual's purely biological nature, notably the quality of life, meaning in life, and aspirations in life, are included under this wider, biological treatise. Our interpretation of the nature of all living matter is intended as an alternative to medical mechanism, which dates back to the beginning of the 20th century. New ideas such as the notions of the human being as nestled in an evolutionary and ecological context, the spontaneous tendency of self-organizing systems for realization and concord, and the central role of consciousness in interpreting, planning, and expressing human reality are unavoidable today in attempts to scientifically understand all living matter, including human life.

  6. [Moral dignity at the beginning of life. The embryo as a marginal being]. (United States)

    Rehmann-Sutter, Christoph


    Ethical questions in relation to human embryos in vitro are today raised by reproductive medicine, preimplantation genetic diagnosis and stem cell research. Various discourses--biological, political and medical--describe the embryo from different perspectives. Empirical investigations of the perceptions and concerns of patients in IVF treatments provide important insights. Referring to a variety of discourses and perspectives, the paper develops an ethical analysis of the responsibility for embryos in vitro, with a special emphasis on the relationships involved. In the context of current discussions about the moral status of the embryo, the paper differentiates between four different meanings of "potentiality" of the embryo: (a) external potentiality, (b) the tendency towards a developmental pathway, (c) the transitive determination by a program, (d) preformation. For different reasons, (a), (c) and (d) are rejected. On the basis of potentiality in the sense of (b), the embryo can be described as a developmental being that gives its developmental potential continuously to the next stage ("self-transcendence") and is on the way of becoming a human. This is a reason for defending ethical responsibility for human embryos as the moral recognition of a growing dignity that becomes more intense with increasing proximity to birth.

  7. In the Beginning was the Genome: Genomics and the Bi-textuality of Human Existence. (United States)

    Zwart, H A E Hub


    This paper addresses the cultural impact of genomics and the Human Genome Project (HGP) on human self-understanding. Notably, it addresses the claim made by Francis Collins (director of the HGP) that the genome is the language of God and the claim made by Max Delbrück (founding father of molecular life sciences research) that Aristotle must be credited with having predicted DNA as the soul that organises bio-matter. From a continental philosophical perspective I will argue that human existence results from a dialectical interaction between two types of texts: the language of molecular biology and the language of civilisation; the language of the genome and the language of our socio-cultural, symbolic ambiance. Whereas the former ultimately builds on the alphabets of genes and nucleotides, the latter is informed by primordial texts such as the Bible and the Quran. In applied bioethics deliberations on genomics, science is easily framed as liberating and progressive, religious world-views as conservative and restrictive (Zwart 1993). This paper focusses on the broader cultural ambiance of the debate to discern how the bi-textuality of human existence is currently undergoing a transition, as not only the physiological, but also the normative dimension is being reframed in biomolecular and terabyte terms.

  8. On the puzzling value of human life

    Directory of Open Access Journals (Sweden)

    Cicovacki Predrag


    Full Text Available The author examines our conflicting attitudes regarding the proper value of human life. While the main issue initially appears to deal with whether or not human life has an intrinsic (or absolute value, it turns out that a far more important and complex issue concerns the tension between the equal value of every human life and the differences in the quality of one’s life. The author discusses the views of Kant, Schweitzer, Berlin, Scheler, and then Hartmann, in whose views the author recognizes the most important contributions to this puzzle.

  9. Care for the beginning of life. The revised Ethical and Religious Directives discuss abortion, contraception, and assisted reproduction. (United States)

    deBlois, J; O'Rourke, K D


    Part 4 of the Ethical and Religious Directives for Catholic Health Care Services--which discusses such controversial issues as abortion, contraception, and assisted reproduction--is informed by a profound respect for human life and the institution of marriage. The controversies are familiar. But many in Catholic healthcare may be less familiar with the principles underlying Church teaching on these issues. Appropriate interpretation and application of these directives require that all concerned be educated in both the theological-ethical and the clinical dimensions of care giving. Directives 38 through 43 deal with reproductive technologies such as in vitro fertilization and surrogacy. Directives 52 and 53 express the Church's consistent teaching on contraceptive interventions. Directives 45 to 48, 50 to 51, and 54 reiterate the Church's firm stance on the inviolability of human life, including nascent human life. However, the directives also say that not all medical interventions resulting in fetal death are prohibited abortions. However, appropriate regard for human life, marriage, and the family require more than mere adherence to the directives' prescriptions and proscriptions. Ethics committees in Catholic healthcare should study clinical data as well as theological materials.

  10. A new life on the small screen and around it: The beginnings of television in socialist Yugoslavia (1955–1970

    Directory of Open Access Journals (Sweden)

    Ildiko Erdei


    Full Text Available Ever since television became institutionalized in socialist Yugoslavia in the late 1950’s, it was closely associated with the idea of a „new life“ in socialist society. As a new technology, as a modern object in the socialist household, and as a medium which enabled the transmission of desirable content for creating socialist citizens and shaping models of socialist „culturality“ and entertainment, television represents a prime terrain for studying the transformations of culture and society in the latter half of the 20th century in Yugoslavia, as well as in the rest of Europe and the world. The paper is mostly based a number of key sources, memoirs, which speak of the history of television in Yugoslavia from the point of view of creators and a wider circle of experts who were involved in it. In this paper I will attempt to shed some light on the dynamics of the process of introducing television into Yugoslavian society, the perplexities, confusions and tensions which this new technology – simultaneously the product and the mediator of modernity – brought with it. Special attention is given to the relationship between television as technology and television as a medium of mass communication, which permanently marked the beginnings of television in Yugoslavia with the tension between „tech“ and „programming“, as well as to the role of television in everyday life.

  11. On the value of human life

    Directory of Open Access Journals (Sweden)

    Višňovský Emil


    Full Text Available The author reflects on the issue of the value of human life in the contexts of current “posthuman” era. There is a host of evidence that the value of human for human beings themselves has been radically reduced or ignored, or replaced by other non-human values, and even neglected. The axiological crisis of humanity, as envisioned by Nietzsche, has become the existential and moral crisis of humanity today. No matter how contemporary technological culture challenges the traditional values, the ancient questions of “how to live?”, “what makes us happy?”, and “what makes life significant?” are still here with us and provide even greater challenges to every individual. The author points to pluralist ways of how to deal with these questions including the “stoic pragmatism” among them.

  12. Fuel pellet relocation behavior in fast reactor uranium-plutonium mixed oxide fuel pin at beginning-of-life

    International Nuclear Information System (INIS)

    Inoue, Masaki; Ukai, Shigeharu; Asaga, Takeo


    The effects of fabrication parameters, irradiation conditions and fuel microstructural feature on fuel pellet relocation behavior in fast reactor fuel pins were investigated. This work focused only on beginning-of-life conditions, when fuel centerline temperature depends largely on the behavior. Fuel pellet relocation behavior in Joyo Mk-II driver could not be characterized because of the lack of data. And the behavior in FFTF driver and its larger diameter type fuel pins could not be characterized because of the extensive lot-by-lot scatters. The behavior both in Monju type and in Joyo power-to-melt type fuel pins were similar to each other, and depends largely on the as-fabricated gap width while the effects of linear heat rate and the extent of microstructural evolution were negligible. And fuel pellet centerline melting seems to affect slightly the behavior. The correlation, which describes the extent of relocation both in Monju type and in Joyo power-to-melt type fuel pins, were newly formulated and extrapolated for Joyo Mk-II driver, FFTF driver and its larger diameter type fuel pins. And the behavior in Joyo Mk-II driver seemed to be similar. On the contrary, the similarity with JNC fuel pins was observed case-by-case in FFTF driver and its larger diameter type fuel pins. (author)

  13. The Beginnings of Astrobiology (United States)

    Wickramasinghe, Chandra


    With the present surge of interest in astrobiology and its emergence as a new scientific discipline in its own right, the role of a celebrated pioneer is all too often forgotten. There can be little doubt that the late Sir Fred Hoyle played a key part in relating astronomical phenomena to questions of life. One of his first contributions in this area was his introduction of the so-called anthropic principle to astronomy. By the late 1940's astronomers had worked out how the simplest chemical element Hydrogen could be converted into Helium in stars, thus providing the main energy source by which stars shine. The building of nuclei beyond Helium by stellar nuclear processes appeared difficult at the time because of instabilities in nuclei with atomic masses 5 and 8. Hoyle had the grand vision of making most if not all of the elements in the Periodic Table in stars. In the early 1950's Hoyle argued that by the very fact of our existence, the existence of life, the element Carbon had to be synthesised in quantity in stars. This could not happen, Hoyle concluded, unless the nucleus of Carbon possessed an energy level corresponding to a hitherto unknown excited state which he was able to calculate. This was necessary so that three Helium nuclei could combine first to form a Carbon nucleus in the excited state that subsequently decayed into the ground state. One of the major triumphs of Hoyle's Anthropic Principle was that his predicted excited state was subsequently discovered in the laboratory by Ward Whaling and Willy Fowler at Caltech. This discovery opened the door to a brand new discipline of Nuclear Astrophysics. In a seminal paper published in 1957, Hoyle together with Willy Fowler, Geoffrey and Margaret Burbidge showed that all the chemical elements needed for life C, N, O, P, Mg, Fe, S ... were made in stars. In a sense Hoyle's work in 1957 already provided the foundation stone for astrobiology. He showed that in essence we were made of stardust.

  14. The European Society of Human Genetics: beginnings, early history and development over its first 25 years. (United States)

    Harper, Peter S


    The European Society of Human Genetics (ESHG) was founded on 15 March 1967, after preliminary discussions at the International Human Genetics Congress in Chicago the previous year and in Copenhagen in early 1967. Its initial meeting was held on 18-19 November 1967, also in Copenhagen, and annual meetings have been held from that time until the present, apart from years in which the International Congress of Human Genetics was also being held. The character of the Society during its early years was strongly influenced by its founding and permanent Secretary, Jan Mohr, head of the Copenhagen Institute of Medical Genetics, whose records are archived in the Tage Kemp/Jan Mohr Archive, now part of the Danish National Archives. These records show Jan Mohr's determination to keep the activities of the Society limited to the holding of an annual meeting to enhance contacts between European human geneticists, and to resist expansion to other activities. Pressures for a wider role of ESHG became irresistible in the late 1980s and a revised constitution, adopted in 1991, reshaped the Society into a more conventional and less restrictive structure. This has allowed it to play a wider and increasingly influential role in the development of human and medical genetics across Europe, with its own Journal, a range of committees covering different aspects of the field and a series of valuable reports on specific important topics, to be described in a forthcoming article on the Society's more recent history.European Journal of Human Genetics advance online publication, 10 May 2017; doi:10.1038/ejhg.2017.34.

  15. [Technology and notion of human life]. (United States)

    Kakimoto, Yoshimi


    This article aims to examine the rules of robotics whose sense is modified in society and which change the notion of human body. Asimov proposed three rules of robotics in his novel of science fiction, which become the basis of the rules concerning the study of the development of robotics. These rules are created in order to avoid harming human beings and to mitigate the variant difficulties of being human being. As for latter, robotics has functioned as a meaning of extension of the physical faculty. Thus, technology develops in the direction of the enhancement of the capability of human body beyond the necessities of life. Robotics doesn't only suggest a rethinking of the notion of a human being but also changes our understanding of the human body.

  16. Athens: New capital of traditional Greek music: Testimonies on musical life at the beginning of the twentieth century

    Directory of Open Access Journals (Sweden)

    Peno Vesna


    Full Text Available During its long Byzantine and Post-Byzantine history Constantinople was the center for church art in general, but especially for music. This old city on the Bosporus maintained its prime position until the beginning of the 20th century when, because of new political and social conditions, the Greek people started to acquire their independence and freedom, and Athens became the new capital in the cultural as well as the political sense. During the first decades of the 20th century the Athenian music scene was marked by an intensive dispute between those musicians who leaned towards the European musical heritage and its methods in musical pedagogy, and those who called themselves traditionalists and were engaged in the preservation of traditional values of church and folk music. The best insight into the circumstances in which Greek musical life was getting a new direction are offered by the numerous musical journals published in Athens before the First World War. Among them, The Formigs is of the special interest, firstly because of the long period during which it was published (1901-1912, and secondly because of its main orientation. The editor Ioannes Tsoklis, a church chanter, and his main collaborator, the famous Constantinopolitan musician and theorist and later Principal of the Department for Byzantine music at Athens musical school Konstantinos Psahos, with other associates firmly represented the traditional position. That is why most of the published articles and the orientation of the journal generally were dedicated to the controversial problems and current musical events that were attracting public attention. The editorial board believed that there was a connection between the preservation of musical traditions and their development on one side, and foreign musical influences that were evident in the promotion of polyphonic church music, which had been totally foreign to the Greek Orthodox church until the end of the 19th century, on

  17. Identifying the Learning Styles and Instructional Tool Preferences of Beginning Food Science and Human Nutrition Majors (United States)

    Bohn, D. M.; Rasmussen, C. N.; Schmidt, S. J.


    Learning styles vary among individuals, and understanding which instructional tools certain learning styles prefer can be utilized to enhance student learning. Students in the introductory Food Science and Human Nutrition course (FSHN 101), taught at the Univ. of Illinois at Urbana-Champaign, were asked to complete Gregorc's Learning Style…

  18. [The beginnings of physiology of the human brain, from antiquity to the Renaissance]. (United States)

    Saban, R


    For more than 3,000 years in Western civilizations, the knowledge of the human body gained very little ground at first, due to taboos. The body was regarded as sacred and Medicine only resorted to plants in order to heal. Hippocrates was not familiar with anatomy as the human body could not be dissected. He developed a theory of humors connected with the primary elements and opposing the dry and the moist. Even though he did not know the nervous system, he nonetheless pointed out that emotions stemmed from the brain and were caused ty particles (pneuma) emitted by the objects around us. Galien was one of the first to mention physiology but could only dissect animals to understand Man. He took up the theory of humors but did not reach any concrete results as he considered the brain as made up of faeces. Only in 1000 AD did Avicenne try to shape the cell theory with its three cells (the ventricles in today's parlance) in direct relation to the nerves, which he described but did not represent. Representation of the nerves was only be given in the mid-13th century by Khalifah in his ophtalmology treaty. Finally, during the Renaissance, when books started conveying both text and pictures, brain physiology emerged; Albert le Grand was its first expounder and his work was then taken up in a 1475 inculabulum in which 5 cells instead of 3 are described and represented. Leonardo da Vinci was the second one; at the end of the 15th century he dissected may corpses to understand human morphology. Unfortunately his work, which was conducted very rigorously from an anatomical point of view only surfaced at the end of the 19th century. He was the first to conduct the anatomical cross-dissection of the brain. Last came Magnus Hundt and Georg Reisch; in the early 16th century they still represented the three cells of Avicenne even though Reisch described more sophisticated connections between the organs of the senses.

  19. Accelerated evolution of the ASPM gene controlling brain size begins prior to human brain expansion.

    Directory of Open Access Journals (Sweden)

    Natalay Kouprina


    Full Text Available Primary microcephaly (MCPH is a neurodevelopmental disorder characterized by global reduction in cerebral cortical volume. The microcephalic brain has a volume comparable to that of early hominids, raising the possibility that some MCPH genes may have been evolutionary targets in the expansion of the cerebral cortex in mammals and especially primates. Mutations in ASPM, which encodes the human homologue of a fly protein essential for spindle function, are the most common known cause of MCPH. Here we have isolated large genomic clones containing the complete ASPM gene, including promoter regions and introns, from chimpanzee, gorilla, orangutan, and rhesus macaque by transformation-associated recombination cloning in yeast. We have sequenced these clones and show that whereas much of the sequence of ASPM is substantially conserved among primates, specific segments are subject to high Ka/Ks ratios (nonsynonymous/synonymous DNA changes consistent with strong positive selection for evolutionary change. The ASPM gene sequence shows accelerated evolution in the African hominoid clade, and this precedes hominid brain expansion by several million years. Gorilla and human lineages show particularly accelerated evolution in the IQ domain of ASPM. Moreover, ASPM regions under positive selection in primates are also the most highly diverged regions between primates and nonprimate mammals. We report the first direct application of TAR cloning technology to the study of human evolution. Our data suggest that evolutionary selection of specific segments of the ASPM sequence strongly relates to differences in cerebral cortical size.

  20. Alfonso Luis Herrera and the Beginnings of Evolutionism and Studies in the Origin of Life in Mexico. (United States)

    Ledesma-Mateos, Ismael; Cleaves, H James


    Alfonso Luis Herrera (1868-1942) was a Mexican biologist, and significant as the principal promoter of Darwinian thought in that country. However, Herrera's thinking went beyond the evolution of living beings, and extended to the question of the origin of life itself and the place of living phenomena in the larger context of the cosmos. Perhaps more significantly, though now largely forgotten, Herrera was among the first to embark on an experimental program to understand the origin of life, one which may be seen as foundational for later workers, most notably Sidney Fox and Alexander Oparin, and which has been resuscitated recently. We review here the development of Herrera's scientific thought on Darwinism and the origin of life and the context in which it developed.

  1. The Beginning of Biochemistry

    Indian Academy of Sciences (India)

    The identification of yeast as the mi- crobe responsible for fermentation of grape juice to wine, and molasses to beer, was one of the earliest great discoveries in biotechnology. Since the time of Louis Pasteur (1822-1875), it was known that during the growth of yeast, intact living cells fermented sugars producing alcohol as ...

  2. The Beginning of Biochemistry

    Indian Academy of Sciences (India)

    Keywords. Fermentation; enzymes; catalysis; proteins; biochemistry. Author Affiliations. T Ramasarma1. INSA Honorary Scientist Solid State and Structural Chemistry Unit and Department of Biochemistry Indian Institute of Science Bangalore 560 012, India. Resonance – Journal of Science Education. Current Issue : Vol.

  3. Beginnings of Group Cohomology

    Indian Academy of Sciences (India)

    as well. Many of the algebraists in the country were his students. Dedicated to my teacher ... GENERAL I ARTICLE. Writing the definition of G action on A in long hand, this means that for each 9 E G, and a E A, .... identity element and for any I E Zl ( G, A), - I defined by (-I) (g) = - I (g) is the inverse of I. It is immedi- ately verified ...

  4. The Beginning of Biochemistry

    Indian Academy of Sciences (India)

    Modern science often seems like a mighty river in flood showing its awesome power, and reminds me of a Burman song on Ganga. - 'whither you come, whither you go? Take the River Kaveri: from its origin in a small pond in a temple in Tala Kaveri in. Western Ghats, it flows on and is joined by many tributaries to.

  5. Human resource development in the beginning phase of nuclear technology development in Japan

    International Nuclear Information System (INIS)

    Yamashita, Kiyonobu


    Japan Research Reactor No.1 (JRR-1) was constructed as the first nuclear reactor in Japan and reached the first criticality in 1957. The construction of both the first BWR and the first PWR were started in the same year 1967 and they started power operation in the same year 1970. Engineers of electrical utilities and vendors gave efforts to have knowledge for reactor engineering mainly on the job training with high self-motivation to contribute for nuclear technology development. A part of them participated in the reactor engineering training course of the JAERI. (author)

  6. Modelling the beginning and end of a planktonic life stage — the distribution of cod eggs and settled juveniles in the North Sea

    DEFF Research Database (Denmark)

    Höffle, Hannes; Munk, Peter


    The North Sea cod stock is close to the southern limit of the species’ range. Therefore, it might be vulnerable to future climate change. Direct as well as indirect effects of climate forcing may have the greatest effects on early life stages. Here we present a study on the distribution of cod...... (Gadus morhua) at the beginning and at the end of the planktonic life stage. The distribution of cod eggs was modelled with generalized additive models (GAMs) for the resence/absence and for the nonzero abundance, using environmental as well as spatial covariates. For comparison, we also examined the egg...... time‐scale. The results showed that the effects of the predicted climate change may be complex and may, even within the same species, be beneficial for one life stage and detrimental for another...

  7. Human Life and American Values Projection (United States)


    compelling evidence exists within multiple disciplines—science and biology, philosophy, religion , and law—that human life begins at conception...this capability is refined for human purposes.76 As with all of these new developments, ethical concerns abound regarding human cloning as well.77...high profits, and could 13 potentially lead to a human cloning / human organ black market and involvement by organized crime.86 A significant

  8. 'The residues of freedom,… tendencies toward true humanism': thoughts on the role of the humanities at the beginning of the twentyfirst century

    Directory of Open Access Journals (Sweden)

    J. Snyman


    Full Text Available Remarks from Kant’s third critique, “The Critique of Judgement”, are taken as guidelines to develop a view on works of art as vessels of knowledge and judgements about what the world appears to be, can be and ought to be. In itself, Kant’s remarks amount to a justification of the study of the arts, i.e. it is for the sake of a world where human beings may experience other human beings as companions in the project to sustain human life. The viability of such an endeavour is borne out by, for example, a recent performance of Beethoven in a most adverse context, and by the fact of international treaties in the past decade against some of the most serious violations of human rights. These treaties could not have been possible were it not for the artistic explorations of the tragedies of these violations.

  9. Beginnings

    DEFF Research Database (Denmark)

    Rehfeld, Jens F


    The gut is the largest endocrine organ in the body. Gut hormones share some characteristics: Their structure groups hormones into families, each of which originate from a single gene. A hormone gene is often expressed in multiple peptides due to tandem genes, alternative splicing or differentiated...

  10. The Beginning of Protohaykian Calendar (United States)

    Broutian, G. H.


    From its foundation, studies in the field of history of Armenian astronomy and Armenian calendars were integral to astrophysical researches of the Byurakan Observatory. It is important to note the monographs and articles of H. Badalian and B. Toumanian in this field. As the result of our work in this field, beginning of the Haykian calendar (BC 2341) and the concept of Protohaykian calendar were established. In the present work an attempt is made to determine the beginning of the oldest Armenian calendar-the Protohaykian calendar. It is shown that Protohaykian calendar was originated when the heliacal rising of the star Spica (α Virgo) was observable from Armenia 8 days before summer solstice. Calculations made on this basis provide date of the beginning of this calendar as BC 9000 with an error not to exceed 80 years. This date is in correspondence with the date of observations of the Pleiades from Metsamor (about BC 9000), that was found a few years ago. Meanwhile, it also corresponds to the geological data, which prove, that the oldest lake (Araratian Sea) in the territory of modern Araratian valley was dried out at the same time. There is also good correlation with the time of cultivation of crops that was done in the territory of historical Armenia about 12000 years ago.

  11. The family and the ontogenesis of human life: An appraisal ...

    African Journals Online (AJOL)

    This article examines critically the role of the family, in a man's journey on earth beginning from his origins through his developmental stages, and earlier states of his history to ageing, dying and death which is the greatest limit situation that terminates man's life here on this planet earth and brings him face to face with His ...

  12. The several elements of intestinal innate immune system at the beginning of the life of broiler chicks. (United States)

    Eren, U; Kum, S; Nazligul, A; Gules, O; Aka, E; Zorlu, S; Yildiz, M


    Functional capacity of digestive system and intestinal adaptive immunity are immature at hatching of broiler chicks. Therefore, intestinal innate immunity after hatching is vital to young chicks. The purpose of this study was to investigate expression and tissue distributions of several elements of the innate immune system (i.e., TLR2, TLR4, CD83, and MHC class II expressing cells) in the intestine of one-day-old chicks. For this purpose, ileum and cecum were examined the under different conditions, which included the control and 1, 3, 6, 12, or 24 h after injection of lipopolysaccharide (LPS) and phosphate buffered saline. The findings indicated that regardless of the antigenic stimulation, Toll-like receptor (TLR) 2 and TLR4 expressing cells were present in the intestinal tissues of one-day-old chicks. We noticed that the intestinal segments have different TLR expression levels after LPS stimulation. Dendritic cells were identified, and they left the intestinal tissue after LPS treatment. MHC class II molecules were diffusely present in both the ileum and cecum. This study demonstrates that the intestinal tissue of one-day-old chicks has remarkable defensive material, including histological properties and several elements of the innate immune system. Microsc. Res. Tech. 79:604-614, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  13. Body as First Space of Communication: The Tonic-Emotional Dialogue in the Beginning of Psychic Life

    Directory of Open Access Journals (Sweden)

    Rui Martins


    Full Text Available In the early stages of ontogenesis, when thesupport for development relies upon the relational function of the mother–baby dyad, the child will organise the foundation of the Self. This process involves a physiological and emotional symbiosis, in a relation with predominance of a tonic-emotional dialogue. The presence or absence of the other, the dynamics of nearness/farness, the postural and gestural dynamics, the containment activities, rhythmic synchronicities and thermal contact, are essential supports to primary organization of the psyche. When these processes are inadequate, they can cause problems of individuation and affirmation of identity, linked to absences or deficiencies in the primary relationship between mother and baby. This perspective leads us to equate the importance of corporeality in the early processes of communication when they are mediated primarily by tonic-emotional processes of communication, imbued with affections, desires and emotions. These processes are essential to the organization of the internal processes that make up this pre-linguistic phase, based on the organization of body schema, ensuring a sense of identity and the possibility of individuation and differentiation from the maternal object. When there are disruptions in this evolutionary dynamics, psychomotor therapy is a privileged resource, providing a safe and container space in which through spontaneous and symbolic play, children learn to transform the feelings, acts and affections in thoughts, projects and words. A desired relationship, allows to experience new forms of expression and conflict resolution, improving emotional and behavioural regulation, and promoting mentoring capacity and executive functions (such as attention, working memory, planning and inhibition of impulses.

  14. Using Artificial Life to Assess the Typicality of Terrestrial Life: Implications for Human Mission Planetary Protection (United States)

    Lupisella, Mark; Powers, Edward I. (Technical Monitor)


    The extent to which extraterrestrial life questions can be addressed, in the absence of an actual example, rests in some measure on the extent to which terrestrial life is representative of life in general since we will likely have to draw heavily, if not completely, from terrestrial life research. One example of a practical question involving extraterrestrial life that arises in preparing for a human mission to another planet such as Mars, is trying to assess and minimize the possible adverse effects of the presence of humans on possible indigenous extraterrestrial life-forms. This paper will present some key planetary protection challenges for a human Mars mission and then focus on one possible approach for assessing the extent to which terrestrial life is representative of biological phenomena in general, informing perhaps, the level of confidence we might have in applying terrestrial research - to extraterrestrial life issues. The approach involves appealing to the relatively new field of Artificial Life (A-Life) to: (1) use what might be the most basic minimal set of life-defining characteristics in (2) a large number of open-ended Artificial Life simulations to generate a "life possibility space" (3) the products of which can be examined for their plausibility within the context of relevant constraining knowledge, so that (4) the remaining possibility space can be examined for its variability relative to terrestrial life, where low variability might suggest that terrestrial life is representative of life in general, and high variability would indicate otherwise.

  15. Small nodular melanoma: the beginning of a life-threatening lesion. A clinical study on 11 cases. (United States)

    Bono, Aldo; Tolomio, Elena; Carbone, Antonino; Moglia, Daniele; Crippa, Federica; Tomatis, Stefano; Santinami, Mario


    Because of its high thickness, nodular melanoma often bears a poor prognosis. Thus, an earlier diagnosis of this type of lesion while it is still thin would be an important step in secondary prevention. The principal aim of the present study was to better define the initial clinical features of nodular melanoma to allow an early diagnosis. A secondary aim was to establish the prognosis of this type of lesion. We retrospectively studied and illustrated the clinical features of 11 small (nodular melanomas seen and treated during a 10-year period. Prognostic characteristics of the various lesions were also described. The results of the study help to describe a small nodular melanoma as a dark and/or pink/red raised lesion, which may be evenly or unevenly colored, with well-defined borders, that often appears de novo. A correct clinical diagnosis was made in 7 of the cases. During a median follow-up of 6 years, none of the patients had local or distant relapses. Detection of small nodular melanoma is feasible by accurate visual inspection, provided that physicians are aware of this type of lesion and maintain the index of suspicion at a high level to bring about curative surgery.

  16. The Beginning of a New Life Following Traumatic Spinal Cord Injury- Patient’s Experiences One Month Post-Discharge

    DEFF Research Database (Denmark)

    Noe, Bodil Bjørnshave; Bjerrum, Merete; Angel, Sanne


    Introduction: Studies show that individuals having suffered traumatic spinal cord injury (TSCI) are challenged by barriers and problems in their transition from hospital rehabilitation to home. This study aims to explore patients’ first-hand experiences of returning home and to compare their post...

  17. Beginning of Viniculture in France (United States)

    McGovern, Patrick E.; Luley, Benjamin P.; Rovira, Nuria; Mirzoian, Armen; Callahan, Michael P.; Smith, Karen F.; Hall, Gretchen R.; Davidson, Theodore; Henkin, Joshua M.


    Chemical analyses of ancient organic compounds absorbed into the pottery fabrics of imported Etruscan amphoras (ca. 500-475 B.C.) and into a limestone pressing platform (ca. 425-400 B.C.) at the ancient coastal port site of Lattara in southern France provide the earliest biomolecular archaeological evidence for grape wine and viniculture from this country, which is crucial to the later history of wine in Europe and the rest of the world. The data support the hypothesis that export of wine by ship from Etruria in central Italy to southern Mediterranean France fueled an ever-growing market and interest in wine there, which, in turn, as evidenced by the winepress, led to transplantation of the Eurasian grapevine and the beginning of a Celtic industry in France. Herbal and pine resin additives to the Etruscan wine point to the medicinal role of wine in antiquity, as well as a means of preserving it during marine transport.

  18. Effect of Color in Human Life


    Sunny Sharma


    Most people are unaware of he propend effect color has on their behavior” Take a minute and imagine the world around you without colors, how boring and unexciting life would be colors play a vital role in our daily lives and if has been proven that our actives and response and influenced by them. Every color has a unique effect on individuals and stimulates various responses e.g. a research has proven that blue color enhances creativity whereas the colors red helps to be focused and has appos...

  19. Perceptions of Psychological Coercion and Human Trafficking in the West Midlands of England: Beginning to Know the Unknown. (United States)

    Dando, Coral J; Walsh, David; Brierley, Robin


    Modern slavery is less overt than historical state-sanctioned slavery because psychological abuse is typically used to recruit and then control victims. The recent UK Draft Modern Slavery Bill, and current UK government anti-slavery strategy relies heavily on a shared understanding and public cooperation to tackle this crime. Yet, UK research investigating public understanding of modern slavery is elusive. We report community survey data from 682 residents of the Midlands of England, where modern slavery is known to occur, concerning their understanding of nonphysical coercion and human trafficking (one particular form of modern slavery). Analysis of quantitative data and themed categorization of qualitative data revealed a mismatch between theoretical frameworks and understanding of psychological coercion, and misconceptions concerning the nature of human trafficking. Many respondents did not understand psychological coercion, believed that human trafficking did not affect them, and confused trafficking with immigration. The public are one of the most influential interest groups, but only if well informed and motivated towards positive action. Our findings suggest the need for strategically targeted public knowledge exchange concerning this crime.

  20. Quality of Life Philosophy II: What is a Human Being?

    Directory of Open Access Journals (Sweden)

    Søren Ventegodt


    Full Text Available The human being is a complex matter and many believe that just trying to understand life and what it means to be human is a futile undertaking. We believe that we have to try to understand life and get a grip on the many faces of life, because it can be of great value to us to learn to recognize the fundamental principles of how life is lived to the fullest. Learning to recognize the good and evil forces of life helps us to make use of the good ones.To be human is to balance between hundreds of extremes. Sometimes we have to avoid these extremes, but at other times it seems we should pursue them, to better understand life. With our roots in medicine, we believe in the importance of love for better health. The secret of the heart is when reason and feelings meet and we become whole. Where reason is balanced perfectly by feelings and where mind and body come together in perfect unity, a whole new quality emerges, a quality that is neither feeling nor reason, but something deeper and more complete.In this paper, we outline only enough biology to clarify what the fundamental inner conflicts are about. The insight into these conflicts gives us the key to a great deal of the problems of life. To imagine pleasures greater than sensual pleasures seems impossible to most people. What could such a joy possibly be? But somewhere deep in life exists the finest sweetness, the greatest quality in life, the pure joy of being alive that emerges when we are fully present and life is in balance. This deep joy of life is what we call experiencing the meaning of life.

  1. Antecedents of Norwegian Beginning Teachers' Turnover Intentions (United States)

    Tiplic, Dijana; Brandmo, Christian; Elstad, Eyvind


    This study aims at exploring several individual, organizational, and contextual factors that may affect beginning teachers' turnover intentions during their first years of practice. The sample consists of 227 beginning teachers (69% female and 31% male) from 133 schools in Norway. The results show four important antecedents of beginning teachers'…

  2. The Role of Human in Relation between Urban Life & Philosophy

    Directory of Open Access Journals (Sweden)

    Qodratullah Qorbani


    Full Text Available Historical documents show that urban life and urbanization is the first manifestation of complete form of human life, and it seems that most of human thoughts, like philosophies, were shaped in the cities and urbanizations. It means that the urban life is a society which has many social factors like: social classes and groups, economy, political power, organizations, family, cultures and geographical and environmental circumstances, that they cause to form many thoughts like human philosophies, then we see that most of past philosophers were in the cities in where urbanization was formed and thinkers could think by using of elements which are grown in such urbanizations. So, the being of urban life is necessary for making philosophical thoughts, because there are such social factors of urban living, can effect human's thinking and shape his/her worldview. But we can see the role of humankinds as a free existent who has divine position, intellect and freedom, then, he/she can manage, control and change the impacts of urban factors on philosophical thought. It means that effects of urbanizations and cultures as clear manifestation of urban life on philosophies is possible only by using of human‘s will and thinking as the central factor of the urban life and philosophy, while he/she can control and change these impacts. In fact, although human is under the impact of social and urban factors, he/she is not determined absolutely, but has freedom and intellect to control and change them. So, there is no place for absolute determinism due to social forces of urban life, but it seems there is a kind of intermediate state between absolute determinism and libertarianism. In this paper, it is tries to analysis the role of social and urban factors as the most important elements of the urban life on philosophy and philosophical thinking, and to argue that how human can manage this process.

  3. Human evolution, life history theory, and the end of biological reproduction. (United States)

    Last, Cadell


    Throughout primate history there have been three major life history transitions towards increasingly delayed sexual maturation and biological reproduction, as well as towards extended life expectancy. Monkeys reproduce later and live longer than do prosimians, apes reproduce later and live longer than do monkeys, and humans reproduce later and live longer than do apes. These life history transitions are connected to increased encephalization. During the last life history transition from apes to humans, increased encephalization co-evolved with increased dependence on cultural knowledge for energy acquisition. This led to a dramatic pressure for more energy investment in growth over current biological reproduction. Since the industrial revolution socioeconomic development has led to even more energy being devoted to growth over current biological reproduction. I propose that this is the beginning of an ongoing fourth major primate life history transition towards completely delayed biological reproduction and an extension of the evolved human life expectancy. I argue that the only fundamental difference between this primate life history transition and previous life history transitions is that this transition is being driven solely by cultural evolution, which may suggest some deeper evolutionary transition away from biological evolution is already in the process of occurring.

  4. Ethical considerations with regard to the sanctity of human life

    African Journals Online (AJOL)

    believe that it is ethical to perform abortion or euthanasia, whatever the circumstances. The problem inherent in discussing these core beliefs is that almost all debate is based on the premise that the sanctity of human life is paramount, and that to kill a human being, whether by abortion or euthanasia, is ethically wrong.

  5. Imunidade relacionada à resposta alérgica no início da vida Immunity related to allergic response at the beginning of life

    Directory of Open Access Journals (Sweden)

    Joaquina M.M. Correa


    Full Text Available OBJETIVO: considerando-se que é na infância que as manifestações alérgicas mais comuns (asma, rinite, dermatite, alergia alimentar ocorrem, porque é no início da vida que o sistema imune pode ser induzido à sensibilização ao invés de tolerância alergênica, analisamos as principais peculiaridades imunológicas do feto e da criança jovem, inerentes à sensibilização e resposta alérgica. MÉTODOS: os autores realizaram revisão literária detalhada concernente à resposta imune inespecífica (barreiras físico-químicas, células mielóides e específica (linfócitos T e B, citocinas do feto e de crianças mais jovens, enfatizando os estudos mais relevantes nos últimos quinze anos. RESULTADOS: vários compartimentos do sistema imune do feto e de crianças mais jovens são diferentes daqueles da criança maior e do adulto. Conseqüentemente, aspectos relativos ao desenvolvimento da imunidade inespecífica e específica, podem contribuir para a geração de atopia. CONCLUSÕES: a predisposição atópica determina-se no início da vida e parece originar-se, além dos fatores genéticos, por aqueles ocorridos no ambiente intra-uterino e fase inicial da infância, os quais influenciam o sistema imune à síntese elevada de IgE.OBJECTIVE: given that the most common allergic manifestations (asthma, rhinitis, dermatitis, food allergies occur during childhood, because the immune system can be induced into sensitization rather than into allergenic tolerance at the beginning of life, we analyzed the main immunological aspects of fetuses and infant in terms of allergic sensitization and response. METHODS: detailed bibliographic revision concerning nonspecific immune response (physical and chemical barriers, myeloid cells and specific immune response (T and B lymphocytes, cytokines of the fetus and infant, with special attention to studies carried out in the last fifteen years. RESULTS: various compartments of the immune system in fetuses and

  6. Natural goodness and the political form of human life

    Directory of Open Access Journals (Sweden)

    Müller Jan


    Full Text Available Ethical Naturalism attempts to explain the objective normativity effective in human practices by reference to the relation between a living individual and the life-form it exhibits. This explanation falls short in the case of human beings (1 - not merely because of their essential rationality, but because the idea of normativity implicit in practice is dependent on the form of normativity’s being made explicit (2. I argue that this explicit form of normativity’s force and claim - the law in general - implies a tension between an explicit norm’s claim to absoluteness and the particularity of the situational case it is applied to. This tension may seem to produce an inherent violence corrupting the very idea of objective normativity inherent in the human form of life (3; in fact, it shows that the human form of life is essentially political. That the human form of life is essentially political does not contradict the idea of objective normativity - provided that this objectivity is not derived from a conception of “natural goodness”, but rather from the actuality of human practice and its principle, justice (4.

  7. Nietzsche and Human Enhancement. On the Concept of Life

    Directory of Open Access Journals (Sweden)

    Marina García-Granero


    Full Text Available This paper exposes the dialogue between Nietzsche and the Darwinian school, highlighting the contrast between two different concepts of «life»: the Darwinian struggle for life or life as will to power. In opposition to the natural selection, which according to nietzsche doesn’t favor the strong and powerful but the mediocre and the many, the German philosopher conceives a breeding (Züchtung, a formation that is physiological as well as moral, and aspires to a true elevation of the human being, through the overcoming of nihilism and the transvaluation of all values from a vitalist perspective.


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    Full Text Available One of the most significant directions of the world-wide contemporary philosophy, phenomenology of life of Anna-Teresa Tymieniecka represents a major path of thinking and acting for the promotion of what does mean the universal valuable in human beingness by disclosing and unfolding an essential modality of understanding and shaping some paradigms of world culture. We face an original author and a reputed activist doing exceptional work to foster a culture of dialogue in the world. The impressive Tymienieckan philosophical work has imposed itself as a great contribution to the heralding of a “New Enlightenment” encompassing humanity in the endeavour of creating, maintaining and developing the wellbeing and the common good of mankind, in securing the human common destiny. Putting in act a holistic and dynamic philosophy upon life and human condition, phenomenology of life offers a viable pattern of communication between different cultures, of overcoming any kind of contradictions in dealing with the fundamental issues of living together and sharing-in-life. We can find elements for tackling and comprehending in a better way our cosmopolitan humanness, due to the opening of a creative approach of identity and otherness, by admitting differentiation and also by working for harmony in the play of life. Throughout new concepts and a very own complex vision of the respect for life, the philosophy-in-act of AnnaTeresa Tymieniecka manifests valences of an integrator enterprise in interpreting the cosmopolitan status of the philosopher in nowadays, in affirming the role of a responsible citizen of the world.

  9. [Health, human development, and governance in Latin America and the Caribbean at the beginning of the 21st century]. (United States)

    Casas-Zamora, Juan Antonio


    The issue of the reciprocal relationship between health and development has recently taken on greater importance in Latin America and the Caribbean (LAC), given the persistence of extreme poverty and the political and social difficulties due to macroeconomic imbalances and crises of governance. This piece reviews concepts of sustainable human development, social determinants of health in general and of health inequities in particular (gender, ethnic group, income level), and the relationship between health and economic growth in the medium term and the long term. An analysis is made of how persistent poverty in countries of LAC relates to disparities in health conditions, access to health services, and health care financing, as well as to such health determinants as nutrition and environmental sanitation. Health inequities most strongly affect the most excluded and vulnerable sectors of the population. In the face of this situation, the author stresses that putting a priority on health inequities is vital to safeguarding the governability and the social and political stability of countries in LAC in the next decade.

  10. Forming of healthy way of life of pupils of institute of noble maidens is in Ukraine (XIX – the beginning of the XX Century

    Directory of Open Access Journals (Sweden)

    Nataliia Sokolova


    Full Text Available Purpose: to define major moments in the process of forming of healthy method of life in the woman educational meeting of Ukraine during ХІХ- ХХ centuries. Material and Methods: analysis and generalization of sources on this question. Results: it is set that not looking on the presence of wide normatively legal base regulating the healthy method of life of pupils of institutes of noble maidens, in practice due attention spared to neither the correct feed nor motive activity. Conclusions: research results confirm that through cruel orders in the walls of establishments, absence of the proper attention to the problem of health of students gradually popularity of institutes of noble maidens falls among young peoples.

  11. Language and life history: a new perspective on the development and evolution of human language. (United States)

    Locke, John L; Bogin, Barry


    It has long been claimed that Homo sapiens is the only species that has language, but only recently has it been recognized that humans also have an unusual pattern of growth and development. Social mammals have two stages of pre-adult development: infancy and juvenility. Humans have two additional prolonged and pronounced life history stages: childhood, an interval of four years extending between infancy and the juvenile period that follows, and adolescence, a stage of about eight years that stretches from juvenility to adulthood. We begin by reviewing the primary biological and linguistic changes occurring in each of the four pre-adult ontogenetic stages in human life history. Then we attempt to trace the evolution of childhood and juvenility in our hominin ancestors. We propose that several different forms of selection applied in infancy and childhood; and that, in adolescence, elaborated vocal behaviors played a role in courtship and intrasexual competition, enhancing fitness and ultimately integrating performative and pragmatic skills with linguistic knowledge in a broad faculty of language. A theoretical consequence of our proposal is that fossil evidence of the uniquely human stages may be used, with other findings, to date the emergence of language. If important aspects of language cannot appear until sexual maturity, as we propose, then a second consequence is that the development of language requires the whole of modern human ontogeny. Our life history model thus offers new ways of investigating, and thinking about, the evolution, development, and ultimately the nature of human language.

  12. Cultural influences on children's understanding of the human body and the concept of life. (United States)

    Panagiotaki, Georgia; Nobes, Gavin


    This study aimed to identify the age by which children begin to demonstrate a biological understanding of the human body and the idea that the purpose of body functioning is to maintain life. The study also explored the influence of education, culturally specific experiences and religion on knowledge acquisition in this domain. Children aged between 4 and 7 years from three different cultural backgrounds (White British, British Muslim, and Pakistani Muslim) were interviewed about the human body and its functioning. At least half of the 4- to 5-year-olds in each cultural group, and almost all 6- to 7-year-olds, referred to the maintenance of life when explaining organs' functions and so were classified as 'life theorizers'. Pakistani Muslim children gave fewer biological responses to questions about organs' functions and the purpose of eating and breathing, but referred to life more than their British counterparts. Irrespective of cultural group, older children understood organ location and function better than younger children. These findings support Jaakkola and Slaughter's (2002, Br. J. Dev. Psychol., 20, 325) view that children's understanding of the body as a 'life machine' emerges around the ages of 4-5 years. They also suggest that, despite many similarities in children's ideas cross-culturally, different educational input and culturally specific experiences influence aspects of their biological understanding. © 2014 The British Psychological Society.

  13. Reading backwards from the beginning: My life with the Psalter

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    NL de Claiss�-Walford


    Full Text Available The Psalter is more than the sum of its individual parts. The book is indeed the collected hymns of ancient Israel and its designation as �the hymnbook of second temple period� is appropriate. But, in addition, the Psalter is a narrative within a poetic text. Contem-porary interest in the Psalter includes the desire to flesh out, give breath to, and stir the nephesh (�the inmost being� of the text of the book of Psalms. But are scholars making any progress? In this article the author answers positively and is intended to provide a summary of this same learning experience.�

  14. Life is three-dimensional, and it begins with molecules.

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    Philip E Bourne


    Full Text Available The iconic image of the DNA double helix embodies the central role that three-dimensional structures play in understanding biological processes, which, in turn, impact health and well-being. Here, that role is explored through the eyes of one scientist, who has been lucky enough to have over 150 talented people pass through his laboratory. Each contributed to that understanding. What follows is a small fraction of their story, with an emphasis on basic research outcomes of importance to society at large.

  15. Art=life? Deleuze, badiou and ontology of the human

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    Filipović Andrija


    Full Text Available The idea of the relation between art and life as becoming-life of art is a consequence of specific modern developments ranging from the Enlightenment to capitalism. This assemblage of thought and practice is present in one of the most dominant art forms today, and the task of this paper is to reassess the current state of affairs in art considering that the current state of affairs in art is a symptom of the global society of control. In order to be emancipatory art, on the one hand, Art presupposes de-substantialization and deessentialization of the biopolitically formed life and the category of Man, while on the other hand it also presupposes a new „generic in-humanum“ (in Badiou, that is, a people to come (in Deleuze as the basis of politicity. Hence, emancipatory art needs to break away with the human in order to reach that which is beyond the current democratic materialism.

  16. Uniquely Human Self-Control Begins at School Age (United States)

    Herrmann, Esther; Misch, Antonia; Hernandez-Lloreda, Victoria; Tomasello, Michael


    Human beings have remarkable skills of self-control, but the evolutionary origins of these skills are unknown. Here we compare children at 3 and 6 years of age with one of humans' two nearest relatives, chimpanzees, on a battery of reactivity and self-control tasks. Three-year-old children and chimpanzees were very similar in their abilities to…

  17. About the beginnings of orthopaedics in Timisoara. (United States)

    Poenaru, Dan V


    The historical and geographical territory of Banat is part of present-day Romania. Timisoara's history, the capital city of Banat region, dates back to the second century B.C. Medical life in Banat was re-organised after the promulgation of the Aulic Laws in the eighteenth century. Thorough research was undertaken through historic manuscripts, old newspapers, biographies and other papers about the history of Romanian medicine. The eighteenth century witnessed the building of three hospitals in Timisoara. In that period, Banat region benefited from the expertise and professionalism of doctors who graduated and were trained mainly in Central and Western European universities. By the beginning of the twentieth century, many medical clinics or sanatoriums specialising in orthopaedics and traumatology were offering their services to the population. Banat region had many good orthopaedists, and one of them was Prof. Dr. Doc. Berceanu, who graduated from the University of Medicine Bucharest and further specialised in Paris, France. He is the founder of the Orthopaedics and Traumatology Clinic in Timisoara.

  18. Michael Mästlin as a Tübingen professor - academic everyday life at the beginning of the 17th century. (German Title: Michael Mästlin als Tübinger Professor - akademischer Alltag an der Schwelle zum 17. Jahrhundert) (United States)

    Wischnath, Johannes Michael

    This contribution elucidates everyday academic at Tübingen University at the beginning of the 17th century, which formed a framework for Michael Mästlin's life as a teacher ad researcher. These activities included administrative tasks, meetings and negotiations, disputations and examinations, church services, academic festivities, group ceremonies and meals. This reconstruction is not only based on unpublished files and minutes of the university and the faculty of arts, but also on the diary of the Greek scholar Martin Crusius, which contains numerous surprising and colourful details from the life of the astronomer.

  19. Pioneers - The Beginning of Danish Electronic Music

    DEFF Research Database (Denmark)

    Kristensen, Thomas Bjørnsten


    Anmeldelse af dobbelt-cd'en Pioneers - The Beginning of Danish Electronic Music, der dokumenterer de tidligste år af dansk elektronisk musiks historie fra 1960-1978. Udgivelsesdato: 29.10......Anmeldelse af dobbelt-cd'en Pioneers - The Beginning of Danish Electronic Music, der dokumenterer de tidligste år af dansk elektronisk musiks historie fra 1960-1978. Udgivelsesdato: 29.10...

  20. Answering the Questions of Beginning Teachers


    Harrington, Ingrid


    Research reports that despite new or beginning teachers being well received by the education profession, their first year experience is often traumatic and difficult nature. This is not a new phenomenon and is a problem shared by many new teachers nationwide and in the western world. Consequently, the retention rate for new teachers is decreasing at an alarming rate and is currently reported that 33% of beginning teachers in New South Wales do not expect to be teaching in public schools withi...

  1. Taina Sfântului Botez- început nou al vieții prin unirea cu Hristos (The Sacrament of Baptism- new beginning of life through union with Christ

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    PhD. Ştefan Florea


    Full Text Available This articles presents the The Holy Sacrament of Baptism- new beginning of life through union with Christ. The sacraments were instituted by Christ and were part of the Liturgical Tradition of the early Christian Church. Holy Baptism is the first of seven Sacraments in the Orthodox Christian Church. The Lord Jesus who instituted Baptism, said of the Disciples: „Go therefore and make disciples of all nations, baptising them in the name of the Father and of the Son and of the Holy Spirit...”(Matthew 28,19. Baptism is necessary for salvation (John 3,5, and man is born a new life, new Christian is a child of God. Baptism is the basis of the whole Christian life held in the Church

  2. Galen and the beginnings of Western physiology. (United States)

    West, John B


    Galen (129-c. 216 AD) was a key figure in the early development of Western physiology. His teachings incorporated much of the ancient Greek traditions including the work of Hippocrates and Aristotle. Galen himself was a well-educated Greco-Roman physician and physiologist who at one time was a physician to the gladiators in Pergamon. Later he moved to Rome, where he was associated with the Roman emperors Marcus Aurelius and Lucius Verus. The Galenical school was responsible for voluminous writings, many of which are still extant. One emphasis was on the humors of the body, which were believed to be important in disease. Another was the cardiopulmonary system, including the belief that part of the blood from the right ventricle could enter the left through the interventricular septum. An extraordinary feature of these teachings is that they dominated thinking for some 1,300 years and became accepted as dogma by both the State and Church. One of the first anatomists to challenge the Galenical teachings was Andreas Vesalius, who produced a magnificent atlas of human anatomy in 1543. At about the same time Michael Servetus described the pulmonary transit of blood, but he was burned at the stake for heresy. Finally, with William Harvey and others in the first part of the 17th century, the beginnings of modern physiology emerged with an emphasis on hypotheses and experimental data. Nevertheless, vestiges of Galen's teaching survived into the 19th century. Copyright © 2014 the American Physiological Society.

  3. Regulatory single nucleotide polymorphisms at the beginning of ...

    Indian Academy of Sciences (India)


    Nov 28, 2015 ... SNPs (rs12228277: T>A, rs12226937: G>A, and rs61761074: T>G) located in the same region of human KRAS. We ... and Merkulova TI 2015 Regulatory single nucleotide polymorphisms at the beginning of intron 2 of the human KRAS gene. J. Biosci. .... Membranes were blocked with 5% nonfat dried milk,.

  4. Development of Life Support System Technologies for Human Lunar Missions (United States)

    Barta, Daniel J.; Ewert, Michael K.


    With the Preliminary Design Review (PDR) for the Orion Crew Exploration Vehicle planned to be completed in 2009, Exploration Life Support (ELS), a technology development project under the National Aeronautics and Space Administration s (NASA) Exploration Technology Development Program, is focusing its efforts on needs for human lunar missions. The ELS Project s goal is to develop and mature a suite of Environmental Control and Life Support System (ECLSS) technologies for potential use on human spacecraft under development in support of U.S. Space Exploration Policy. ELS technology development is directed at three major vehicle projects within NASA s Constellation Program (CxP): the Orion Crew Exploration Vehicle (CEV), the Altair Lunar Lander and Lunar Surface Systems, including habitats and pressurized rovers. The ELS Project includes four technical elements: Atmosphere Revitalization Systems, Water Recovery Systems, Waste Management Systems and Habitation Engineering, and two cross cutting elements, Systems Integration, Modeling and Analysis, and Validation and Testing. This paper will provide an overview of the ELS Project, connectivity with its customers and an update to content within its technology development portfolio with focus on human lunar missions.

  5. Patterns of Analogical Reasoning among Beginning Readers (United States)

    Farrington-Flint, Lee; Wood, Clare; Canobi, Katherine H.; Faulkner, Dorothy


    Despite compelling evidence that analogy skills are available to beginning readers, few studies have actually explored the possibility of identifying individual differences in young children's analogy skills in early reading. The present study examined individual differences in children's use of orthographic and phonological relations between…

  6. The Beginnings of X-ray Crystallography

    Indian Academy of Sciences (India)

    IAS Admin

    The Beginnings of X-ray Crystallography. A Profile on the Two Braggs. Those were the days when Science was hovering around the wave–particle duality. William. Henry Bragg was toying with the idea that X-rays are particles and the observation made by Max von Laue that X-rays are diffracted by crystals could indeed ...

  7. Human Life History Strategies

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    Kristine J. Chua


    Full Text Available Human life history (LH strategies are theoretically regulated by developmental exposure to environmental cues that ancestrally predicted LH-relevant world states (e.g., risk of morbidity–mortality. Recent modeling work has raised the question of whether the association of childhood family factors with adult LH variation arises via (i direct sampling of external environmental cues during development and/or (ii calibration of LH strategies to internal somatic condition (i.e., health, which itself reflects exposure to variably favorable environments. The present research tested between these possibilities through three online surveys involving a total of over 26,000 participants. Participants completed questionnaires assessing components of self-reported environmental harshness (i.e., socioeconomic status, family neglect, and neighborhood crime, health status, and various LH-related psychological and behavioral phenotypes (e.g., mating strategies, paranoia, and anxiety, modeled as a unidimensional latent variable. Structural equation models suggested that exposure to harsh ecologies had direct effects on latent LH strategy as well as indirect effects on latent LH strategy mediated via health status. These findings suggest that human LH strategies may be calibrated to both external and internal cues and that such calibrational effects manifest in a wide range of psychological and behavioral phenotypes.

  8. An African Thought on the Ethics of Human Foetal Life | Ebeh ...

    African Journals Online (AJOL)

    This paper presents an African thought on the ethics of human foetal life and this can be discussed against the backdrop of the African concept of life, person and community. In the process, it examines the fact of humanity and personhood of the human foetus and the role of the community in the determinant of humanity and ...

  9. From the beginning of radon therapy

    International Nuclear Information System (INIS)

    Schuettmann, W.


    The revival of the radon therapy in several countries since the end of the Second World War was the occasion for a review to the beginnings of this special form of radiotherapy. Initially the early history of radioactivity research is described which among others led to the detection of the emanation as a daughter product of radium. After this followed the evidence of the emanation as a constituent of the natural atmosphere. The establishment of its presence in spring-waters led to the knowledge that there are more than average concentrations of emanation in several mineral springs. In the second part of the article the therapeutic use of the natural radon springs initiated by this is described in its development and importance for Austria (Badgastein, St. Joachimsthal) and Germany (Bad Brambach) up to the beginning of the First World War. (author)

  10. [Dementia. Most frequent forms of beginning]. (United States)

    Arizaga, Raúl L; Cristalli, Diana O; Golimstok, Angel; Saredo, Gustavo


    In the present chapter, that is part of a more comprehensive work performed by the Argentine Consortium for Dementia Study - Consortium Argentino para el Estudio de la Demencia (CAED), we describe the most frequent forms of beginning for the four more prevalent types of dementia: Alzheimer's disease, dementia with Lewy bodies, vascular dementia and frontotemporal dementia). Despite this, it must be kept in mind, that frequently the clinical presentation is not typical and the diagnostic impression at the disease's beginning is controversial comparing it with the etiological diagnosis reached when the dementia is definitively installed. This issue must be considered when the initial impression is given to the patient and/or relatives. It must be clarified, in this instance, that this impression is based in statistical data of ways of presentation, but the definitive diagnosis could be different according to the dementia evolution.

  11. Oocyte activation and latent HIV-1 reactivation: AMPK as a common mechanism of action linking the beginnings of life and the potential eradication of HIV-1. (United States)

    Finley, Jahahreeh


    In all mammalian species studied to date, the initiation of oocyte activation is orchestrated through alterations in intracellular calcium (Ca(2+)) signaling. Upon sperm binding to the oocyte plasma membrane, a sperm-associated phospholipase C (PLC) isoform, PLC zeta (PLCζ), is released into the oocyte cytoplasm. PLCζ hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) to produce diacylglycerol (DAG), which activates protein kinase C (PKC), and inositol 1,4,5-trisphosphate (IP3), which induces the release of Ca(2+) from endoplasmic reticulum (ER) Ca(2+) stores. Subsequent Ca(2+) oscillations are generated that drive oocyte activation to completion. Ca(2+) ionophores such as ionomycin have been successfully used to induce artificial human oocyte activation, facilitating fertilization during intra-cytoplasmic sperm injection (ICSI) procedures. Early studies have also demonstrated that the PKC activator phorbol 12-myristate 13-acetate (PMA) acts synergistically with Ca(2+) ionophores to induce parthenogenetic activation of mouse oocytes. Interestingly, the Ca(2+)-induced signaling cascade characterizing sperm or chemically-induced oocyte activation, i.e. the "shock and live" approach, bears a striking resemblance to the reactivation of latently infected HIV-1 viral reservoirs via the so called "shock and kill" approach, a method currently being pursued to eradicate HIV-1 from infected individuals. PMA and ionomycin combined, used as positive controls in HIV-1 latency reversal studies, have been shown to be extremely efficient in reactivating latent HIV-1 in CD4(+) memory T cells by inducing T cell activation. Similar to oocyte activation, T cell activation by PMA and ionomycin induces an increase in intracellular Ca(2+) concentrations and activation of DAG, PKC, and downstream Ca(2+)-dependent signaling pathways necessary for proviral transcription. Interestingly, AMPK, a master regulator of cell metabolism that is activated thorough the induction of cellular

  12. The life and times of religion and human rights

    NARCIS (Netherlands)

    Gaay Fortman, B. de; Salih, Mohamed


    Seen from a human perspective and as communal protection of human dignity, human rights are universal challenges to which all major traditions of the human family have subscribed. However, ways and means as to the realisation of this universal human ideal have been subject to controversy because of

  13. Regulatory single nucleotide polymorphisms at the beginning of ...

    Indian Academy of Sciences (India)

    Supplementary figure 2. Long-range interactions were detected between the beginning of intron 2 of human K-Ras and promoter region of CASC1 and Lyrm5 genes (represented by rectangles). These regions may also interact indirectly via potential enhancer (chr12:25346001-25541636) represented by right oval).


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    Full Text Available No doubt, if one comes to search for the truth, he/she will find it. It is a journey to the inner self translated as simple yet complex developments of narrative symbols and myths. We are transported into a magical world of subtle senses and meanings where one has to learn the different traces of history that we are transuded into. There are two sides of this mirroring that we find in those two tales. The first one takes us, metaphorically, in front of the tree of life, the source of knowledge that is accessible only by the pure hearted. The connectionthrough the person of the Sun Goddess Amaterasu Omikami can only point out where the light does deviate all of us. The second one is an imperative message, as a meditation, the moment that we disconnect from our minds. Those two parts can feed us with the knowledge of the human beings, in order to fill the love core connected with the feeling coming out from the experience of these two tales. You can take a magical tour into the world of the mirrors that we are revealed here and try to gaze into the future, searching for meanings that perhaps you have never thought about. Either way it is a positive approach towards knowing who we really are.

  15. SNEV overexpression extends the life span of human endothelial cells

    International Nuclear Information System (INIS)

    Voglauer, Regina; Chang, Martina Wei-Fen; Dampier, Brigitta; Wieser, Matthias; Baumann, Kristin; Sterovsky, Thomas; Schreiber, Martin; Katinger, Hermann; Grillari, Johannes


    In a recent screening for genes downregulated in replicatively senescent human umbilical vein endothelial cells (HUVECs), we have isolated the novel protein SNEV. Since then SNEV has proven as a multifaceted protein playing a role in pre-mRNA splicing, DNA repair, and the ubiquitin/proteosome system. Here, we report that SNEV mRNA decreases in various cell types during replicative senescence, and that it is increased in various immortalized cell lines, as well as in breast tumors, where SNEV transcript levels also correlate with the survival of breast cancer patients. Since these mRNA profiles suggested a role of SNEV in the regulation of cell proliferation, the effect of its overexpression was tested. Thereby, a significant extension of the cellular life span was observed, which was not caused by altered telomerase activity or telomere dynamics but rather by enhanced stress resistance. When SNEV overexpressing cells were treated with bleomycin or bleomycin combined with BSO, inducing DNA damage as well as reactive oxygen species, a significantly lower fraction of apoptotic cells was found in comparison to vector control cells. These data suggest that high levels of SNEV might extend the cellular life span by increasing the resistance to stress or by improving the DNA repair capacity of the cells

  16. Dreptul omului de a fi protejat de stresul negativ excesiv – un nou drept fundamental al omului postmodern, la începutul sec. XXI (The right to be protected from the negative stress – a new fundamental right of the post-modern human, at the begining of the XXIst century

    Directory of Open Access Journals (Sweden)

    Mădălina Virginia ANTONESCU


    Full Text Available The development of the human rights field, at the beginning of XXIst century, brings new challenges for the legal academic school under the pressure to realize a continuous effort to adapt itself to multiple changes of the global world and equally, to those changes resulted from the state and non-state entities actions, under the impact of specific threats and problems. Within this context, we propose in this paper “a right of human being to be protected from stress -the negative excessive stress-“; in our opinion, this right can be considered, from the beginning, to belong to the IVth generation of human rights, after the category of solidarity rights. Particularly, we consider that it should be adopted (under the aegis of UN.GA a “Charter for the human rigths protection of the metropolitan man”, facing the situations and conditions of life generating a level of stress that is an exclusive feature of the metropolitan style of life, an action prescribed in order to rise concretely the level of protection for human rights, face to challenges brought by postmodern lifestyle. This Charter would realize a consecration of human rights starting from a specific quality of human being (as “living into great urban agglomerations”- metropolis, megalopolis, and by taking into account the universality of the urbanization phenomena, as specific phenomena of the global age, at the beginning of the XXIst century. Quality of the human being “to live into great urban agglomerations” should be taken, in our opinion, into consideration, more attentively, by the XXIst century legal academic school, this quality shifting towards a legal quality, and generating rights and obligations specific to the human being of the XXIst century global society. Also, it should be recommended to ellaborate (possibly, through a Romanian proposal within UN.GA a declaration, signed by UN states, regarding an international day of fighting against negative excessive

  17. Politics drives human functioning, dignity, and quality of life. (United States)

    Barber, Brian K; Spellings, Carolyn; McNeely, Clea; Page, Paul D; Giacaman, Rita; Arafat, Cairo; Daher, Mahmoud; El Sarraj, Eyad; Mallouh, Mohammed Abu


    Too little is known about human functioning amidst chronic adversity. We addressed that need by studying adult Palestinians in the occupied Palestinian territories (oPt), a population that has experienced longstanding economic and political hardships. Fourteen group interviews were conducted in February, 2010 in Arabic by local fieldworkers with 68 participants representing the main stratifications of Palestinian society: gender, region, refugee status, and political affiliation. Interview tasks included each participant: describing someone doing well and not well, free listing domains of functioning, and prioritizing domains to the three most important. Thematic analyses highlighted the dominating role of the political domain of functioning (e.g., political structures, constraints, effects, identity, and activism) and the degree to which political conditions impacted all other realms of functioning (economic, education, family, psychological, etc.). The discussion links the findings to relevant theory and empirical work that has called attention to the need to include the political in frameworks of quality of life. It also emphasized that values, such as justice, rights, dignity and self-determination, that underlie political structures and policies, are key elements of human functioning. This is the case not only in the oPt, but in any society where power imbalances marginalize segments of the population. Copyright © 2014 Elsevier Ltd. All rights reserved.

  18. Beginning phase of career manager for non-formal education


    Kostková, Blanka


    This thesis deals with the beginning phase of career manager for organization non- formal education. The work examines the process that precedes the onset school manager to executive positions primarily in terms of motivation, expectations and subsequent reality. It describes the initial phase of his work in a new role in life from the perspective of the management of school facilities and other activities associated with this process . The work is mapped to what extent the entrance to the Di...

  19. Behaviorism and the beginnings of close reading. (United States)

    Gang, Joshua


    Many of close reading's most enduring assumptions and techniques have their origins in psychological behaviorism. Beginning with I. A. Richards's critical work from the 1920s, this article demonstrates the central place of behaviorist ideas in New Critical theories of poetry. Despite explicitly disparaging Richards's behavioristic poetics, Brooks's Well Wrought Urn and Wimsatt and Beardsley's "intentional fallacy" perpetuated behaviorism's influence on literary criticism. This article traces how the New Critics translated behavioristic psychology into poetic formalism and discusses the implications of this for contemporary critical practice.

  20. Wherever We Find Friends there Begins a New Life: Tagore and China

    Directory of Open Access Journals (Sweden)

    Jana Rošker


    Full Text Available Tagore made a deep impression upon the Chinese culture and society. In 1923, the Jiangxue she 講學社 (Beijing Lecture Association invited Rabindranath Tagore to deliver a series of talks. The Jiangxue she Association was established in September 1920 and represented one of the many institutions that came to life in China during the May Fourth Movement. Since then, almost all of his works in English have been translated into Chinese. He came to China just when the latter was beginning her Renaissance and his visit certainly gave a great impetus to this new movement. His poems of Stray Birds and The Crescent Moon have created new styles of prosody in the new Chinese poetry. A Crescent Moon Society (for poetry and a Crescent Moon magazine were started immediately after this event by Hu Shi 胡适 (Hu 2002: 90. During his visit, Tagore raised two basic questions, one about the relation between tradition and modernity, and the other about the usual identification of modernisation with Westernisation. Since the May Fourth Movement, China has also been concerned with these questions and Chinese intellectuals have come out with different answers. These questions, however, were important not only for China but for India as well. Such debates and the revaluation of various answers represented the most important condition for a consolidation of new ideologies, which formed a political basis for the changing societies of both countries.

  1. Difficulties encountered at the beginning of professional life: results of a 2003 pilot survey among undergraduate students in Paris Rene Descartes University (France). (United States)

    Benbelaïd, R; Dot, D; Levy, G; Eid, N


    In addition to dental hospital clinical activity, dental students at Paris Rene Descartes University have the opportunity in their final year of study to practise clinically in a dental office, as associates. This paper outlines a pilot, experimental study designed to assess student reaction to this Vocational Clinical Activity (VCA) in order to identify relevant weaknesses of the undergraduate programme. Using questionnaires, data were collected for each of the following clinical or management skills: clinical difficulty, therapeutic decision-making, patient/practitioner relationship, time management, administrative matters and technical problems. Students were asked to rank each item in order of difficulty (1, high level to 6, low level). A high response rate was observed (90%) among the 50 undergraduate VCA students. The results pointed out three main difficulties encountered by undergraduate students during the VCA: time management (90% of the students), administrative matters (85% of the students) and clinical decision-making (80% of the students). These preliminary results need further investigation. However, they give us the incentive to carry on with this type of assessment and to extend it to young, qualified colleagues' perceptions and to other French Universities.

  2. Influence of sports on human mental and physical development in various stages of life


    SLÁDKOVÁ, Jitka


    The thesis deals with the impact of sports and physical activity on human physical and mental development in various developmental stages of life. It contains a brief description of the stages of life and presents the possibilities, nature and influence of sports and physical activity on human physical and mental state.

  3. Dynamics and Ultradian Structure of Human Sleep in Real Life. (United States)

    Winnebeck, Eva Charlotte; Fischer, Dorothee; Leise, Tanya; Roenneberg, Till


    The temporal dynamics that characterize sleep are difficult to capture outside the sleep laboratory. Therefore, longitudinal studies and big-data approaches assessing sleep dynamics are lacking. Here, we present the first large-scale analysis of human sleep dynamics in real life by making use of longitudinal wrist movement recordings of >16,000 sleep bouts from 573 subjects. Through non-linear conversion of locomotor activity to "Locomotor Inactivity During Sleep" (LIDS), movement patterns are exposed that directly reflect ultradian sleep cycles and replicate the dynamics of laboratory sleep parameters. Our current analyses indicate no sex differences in LIDS-derived sleep dynamics, whereas especially age but also shift work have pronounced effects, specifically on decline rates and ultradian amplitude. In contrast, ultradian period and phase emerged as remarkably stable across the tested variables. Our approach and results provide the necessary quantitative sleep phenotypes for large field studies and outcome assessments in clinical trials. Copyright © 2017 Elsevier Ltd. All rights reserved.

  4. Chronomics and ``Glocal'' (Combined Globaland Local) Assessment of Human Life (United States)

    Otsuka, K.; Cornélissen, G.; Norboo, T.; Takasugi, E.; Halberg, F.

    Most organisms, from cyanobacteria to mammals, are known to use circadian mechanisms to coordinate their activities with the natural 24-hour light/dark cycle and/or interacting socio-ecologic schedules. When the human clock gene was discovered in 1997, it was surprising to see that it was very similar in all earthly life. Recent findings suggest that organisms which evolved on Earth acquired many of the visible and invisible cycles of their habitat and/or of their cosmos. While circadian systems are well documented both time-macroscopically and time-microscopically, the temporal organization of physiological function is much more extensive. Long-term physiological quasi-ambulatory monitoring of blood pressure and heart rate, among other variables, such as those of the ECG and other tools of the neuroendocrinologic armamentarium, have already yielded information, among others, on circaseptan (about 7-day), transyears and cisyears (with periods slightly longer or shorter tha n one year, respectively), and circadecennian (about 10-year) cycles; the nervous system displays rhythms, chaos and trends, mapped as chronomes. Chronomes are time structures consisting of multifrequency rhythms covering frequencies over 18 orders of magnitude, elements of chaos, trends in chaotic and rhythmic endpoints, and other, as-yet unresolved variability. These resolvable time structures, chronomes, in us have counterparts around us, also consisting of rhythms, trends and chaos, as is increasingly being recognized. In 2000, we began a community-based study, relying on 7-day/24-hour monitoring of blood pressure as a public service. Our goal was the prevention of stroke and myocardial infarction and of the decline in cognitive function of the elderly in a community. Chronomic detection of elevated illness-risks aim at the prevention of diseases of individuals, such as myocardial infarctions and strokes, and, equally important, chronomics resolves illness of societies, such as crime and war

  5. Human milk: a source of more life than we imagine

    NARCIS (Netherlands)

    Jeurink, P.V.; Bergenhenegouwen, van J.; Jimenez, E.; Knippels, L.M.J.; Fernandez, L.; Garssen, J.; Knol, J.; Rodriguez, J.M.; Martin, R.


    The presence of bacteria in human milk has been acknowledged since the seventies. For a long time, microbiological analysis of human milk was only performed in case of infections and therefore the presence of non-pathogenic bacteria was yet unknown. During the last decades, the use of more

  6. Reflections on human error - Matters of life and death (United States)

    Wiener, Earl L.


    The last two decades have witnessed a rapid growth in the introduction of automatic devices into aircraft cockpits, and eleswhere in human-machine systems. This was motivated in part by the assumption that when human functioning is replaced by machine functioning, human error is eliminated. Experience to date shows that this is far from true, and that automation does not replace humans, but changes their role in the system, as well as the types and severity of the errors they make. This altered role may lead to fewer, but more critical errors. Intervention strategies to prevent these errors, or ameliorate their consequences include basic human factors engineering of the interface, enhanced warning and alerting systems, and more intelligent interfaces that understand the strategic intent of the crew and can detect and trap inconsistent or erroneous input before it affects the system.

  7. [The beginning of the Cuban demographic revolution]. (United States)

    Hernandez Castellon, R


    The characteristics of the Cuban demographic revolution associated with the main economic, political, and social changes in the country are analyzed. The authors begin with a brief historical outline of the political-economic situation in the country in the middle of the 19th century. There is emphasis on the dependency of the Cuban economy and its monoproducer nature (with sugar being the major export). This was due to the Spanish colonization and to the subsequent American neocolonization. The discovery of the cause for yellow fever by a Cuban physician and the sanitation campaign conducted by the Americans contributed to a diminishing of mortality. A great migratory flow occurred due to the price of sugar in the world market. This must have influenced Cuban demographic patterns which are a major factor linked to the demographic revolution. The influence on proliferation of urbanization and educational trends is emphasized. The low participation in economic activities of women during the early part of the century did affect fertility levels. The trends in mortality throughout the period 1907-43 are pointed out. It was found that 1 major aspect which had a bearing on Cuban demographic patterns was the 2 large migratory flows. An analysis of growth rates in the population--which also confirms the demographic changes in Cuba--is presented. It is concluded that the 4th decade of this century witnessed Cuba's entry in a new stage of the demographic revolution, a stage in which decreased fertility and mortality go together to create a new period. (author's)

  8. First Contact: Expectations of Beginning Astronomy Students (United States)

    Lacey, T. L.; Slater, T. F.


    Three hundred seven undergraduate students enrolled in Introductory Astronomy were surveyed at the beginning of class to determine their expectations for course content. The course serves as a survey of astronomy for non-science majors and is a distribution course for general education core requirements. The course has no prerequisites, meets three times each week for 50 minutes, and represents three semester credit hours. The university catalog describes the course with the title "PHYSICS 101 - Mysteries of the Sky" and the official course description is: a survey of the struggle to understand the Universe and our place therein. The structure, growth, methods, and limitations of science will be illustrated using the development of astronomy as a vehicle. Present day views of the Universe are presented. Two questions were asked as open response items: What made you decide to take this course? and What do you expect to learn in this course? The reasons that students cited to take the course, in order of frequency, were: interested in astronomy, interesting or fun sounding course, required general education fulfillment, recommendation by peer. Secondary reasons cited were required for major or minor, general interest in science, and was available in the schedule. Tertiary reasons listed were recommendation by advisor or orientation leader, inflate grade point average, and heard good things about the teacher. The students' expectations about what they would learn in the course were numerous. The most common objects listed, in order of frequency, were: stars, constellations, planets, galaxies, black holes, solar system, comets, galaxies, asteroids, moon, and Sun. More interesting were the aspects not specifically related to astronomy. These were weather, atmosphere, UFOs and the unexplained, generally things in the sky. A mid-course survey suggests that students expected to learn more constellations and that the topics would be less in-depth.

  9. Ethical considerations with regard to the sanctity of human life

    African Journals Online (AJOL)

    ethical debates do not even attempt to substantiate this idea, perhaps because it is inherently impossible to do so. Often when the idea of the sanctity of life is discussed, bioethical debaters bring up the 'slippery slope' concept: which essentially ...

  10. Is the discovery of the novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like pandemic? (United States)

    Chan, Jasper F W; Li, Kenneth S M; To, Kelvin K W; Cheng, Vincent C C; Chen, Honglin; Yuen, Kwok-Yung


    Fouchier et al. reported the isolation and genome sequencing of a novel coronavirus tentatively named "human betacoronavirus 2c EMC/2012 (HCoV-EMC)" from a Saudi patient presenting with pneumonia and renal failure in June 2012. Genome sequencing showed that this virus belongs to the group C species of the genus betacoronavirus and phylogenetically related to the bat coronaviruses HKU4 and HKU5 previously found in lesser bamboo bat and Japanese Pipistrelle bat of Hong Kong respectively. Another patient from Qatar with similar clinical presentation and positive RT-PCR test was reported in September 2012. We compare and contrast the clinical presentation, laboratory diagnosis and management of infection due to this novel coronavirus and that of SARS coronavirus despite the paucity of published information on the former. Since 70% of all emerging infectious pathogens came from animals, the emergence of this novel virus may represent another instance of interspecies jumping of betacoronavirus from animals to human similar to the group A coronavirus OC43 possibly from a bovine source in the 1890s and the group B SARS coronavirus in 2003 from bat to civet and human. Despite the apparently low transmissibility of the virus at this stage, research preparedness against another SARS-like pandemic is an important precautionary strategy. Copyright © 2012 The British Infection Association. Published by Elsevier Ltd. All rights reserved.


    Directory of Open Access Journals (Sweden)

    Andreea-Ioana Cozianu


    Full Text Available The present approach studies the probability of the decomposition of the current international geopolitical system in the context of the EU’s socio-economical and political stagnation. We do not intend to say that European Union represents the determinant factor for the system’s decomposition, since we have not found EU as a major player on the International Relations arena, but we are more pointing out that EU’s dream to recover a lost greatness will not so soon fulfil. We also intend to refer to those elements that actually connect EU to a changing world: competitive human resources engaged in the market economy, and hardly its values, like the promotion of the human rights and democracy. So, is it possible to play by the rules and be regarded as a powerful player on the same time?! International Relations system diversity makes it almost impossible. (NeoLiberal concepts like “democratic peace” or “international institutions”, the promotion of the human rights and of democracy get pale in the face of a reality dominated by an emerging Russian Federation that plays by the (Neo Realism power commandments. And so we get to deal with the Ukrainian situation where to each Western sanction, The Russian Federation opposes a “tank”.

  12. The family and the ontogenesis of human life: An appraisal ...

    African Journals Online (AJOL)

    Journal of Religion and Human Relations. Journal Home · ABOUT · Advanced Search · Current Issue · Archives · Journal Home > Vol 1, No 6 (2014) >. Log in or Register to get access to full text downloads.


    Directory of Open Access Journals (Sweden)

    Ядвіга Дашиновська


    Full Text Available The notion of life quality has been observed in numerous fields of science including pedagogy. This discipline perceives human life in the light of continuous changes that are accompanied by the transformations of the man himself and the creation of various ways of interactions and balance between them and the surrounding world. Their direction depends on human vision of life and the role man accepts to play in it as well as the value that is ascribed by man to his life – here appears the question concerning the quality of life. From pedagogical point of view quality of life is indicated by satisfaction with good life achieved throughout the realization of the values that constitute the basis for any human pursuit and objectives. Nevertheless, in order to influence one’s own life quality man must fulfil a necessary condition that is to be a creator not just a reproducer. In the paper herein there has undertaken an attempt to answer the question concerning the role of creative activity in the development of man and the quality of human life. It turns out that conscious application of one’s own potential and creative activity enables the man to become self-realized and favours the satisfaction with life.

  14. Vegetal paleoenvironment in the human settlements found in Payre Cave at the end of the Middle Pleistocene and the beginning of the Upper Pleistocene (Ardeche, Francia

    Directory of Open Access Journals (Sweden)

    Kalai, Chafika


    Full Text Available The Middle Paleolithic site named Payre is located in the south-east of France, in the Middle Rhone Valley, in the Mediterranean world. Since 1990, the excavations have yielded a sequence dated from the isotopic stages 7 to 5. The palynological study based on settlement levels from the isotopic stages 6 and 5 has provided us with information about the vegetal environment of the end of the Middle Pleistocene and the beginning of the Upper Pleistocene. When men came, the landscape was semi-forest and the climate was temperate with Mediterranean influences.

    [es] El emplazamiento arqueológico del Paleolítico Medio de Payre se sitúa al sureste de Francia, en el valle del Ródano, en el contexto mediterráneo actual. Las excavaciones que vienen llevándose a cabo desde 1990 presentan una secuencia fechada en los estadios isotópicos 7 al 5. El estudio palinológico de los niveles de ocupación de los estadios isotópicos 6 y 5 nos informan sobre el contexto vegetal del final del Pleistoceno Medio y de principios del Pleistoceno Superior. Los diferentes periodos climáticos se caracterizan por la predominancia de los taxones arbóreos como Quercus t. ilex y Buxus. El paisaje es a lo largo del diagrama, globalmente semi-abierto y el clima de tipo templado presenta influencias mediterráneas. [fr] Le gisement paléolithique moyen de Payre est situé dans le sud-est de la France, dans la moyenne vallée du Rhône en contexte méditerranéen. Les fouilles, qui s'y déroulent depuis 1990, livrent une séquence datée des stades isotopiques 7 à 5. L'étude palynologique des niveaux d'occupation des stades isotopiques 6 et 5 nous informe sur le contexte végétal de la fin du Pléistocène moyen et du début du Pléistocène supérieur. Le paysage est, lors des diverses occupations humaines, globalement semi-ouvert et le climat de type tempéré sous influence méditerranéenne.

  15. The Beginning Before the Beginning: Hegel and the Activation of Philosophy

    Directory of Open Access Journals (Sweden)

    Paul Ashton


    Full Text Available This paper suggests that it is not enough to simply account for the lsquo;beginningrsquo; in Hegelrsquo;s philosophy. To capture the speculative depth of Hegelrsquo;s thinking one must also account for the beginning of philosophy as such. That is, how or why the philosopher begins or lsquo;the beginning before the beginningrsquo;. The question of the activation of the philosophical project itself is explored through Hegelrsquo;s notion of the lsquo;need of philosophyrsquo; and the fundamental relation between the historical event of the French Revolution and philosophical thinking. This question is explored through a critical discussion of those thinkers who are also concerned with the philosophy/revolution relation but are critical of Hegelrsquo;s approach. It is suggested that these critical readings employ a thematic approach to both Hegel and philosophy more generally. This approach renders them unable to appreciate Hegelrsquo;s philosophy speculatively and as a consequence the relation between philosophy and freedom, via the revolution, is misconstrued. In contradistinction to these readings the question of how one encounters Hegelrsquo;s thought non-thematically is explored through an analysis of the willingness of the would-be philosopher to activate themselves into the philosophical project and dwell with Hegel in the lsquo;wersquo;. Rather than providing answers to the questions raised, this paper seeks to act as a provocation for a renewed encounter with Hegelrsquo;s philosophy. br /

  16. Dynamics and stabilization of the human gut microbiome during the first year of life

    DEFF Research Database (Denmark)

    Bäckhed, Gert Fredrik; Roswall, Josefine; Peng, Yangqing


    The gut microbiota is central to human health, but its establishment in early life has not been quantitatively and functionally examined. Applying metagenomic analysis on fecal samples from a large cohort of Swedish infants and their mothers, we characterized the gut microbiome during the first...... of the microbiome. Our findings establish a framework for understanding the interplay between the gut microbiome and the human body in early life....

  17. [Beginning Knowledge of Transfusion in Japan]. (United States)

    Mazda, Toshio; Shimizu, Masaru


    Blood components and plasma derivatives are two of the most useful tools in modern medicine. When the Portuguese opened the maritime routes to the Far East in the 16th century. Western medicine traveled to Japan on the trading vessels that carried physicians and barber-surgeons to care for the body and Christian missionaries to care for the soul. Skilled interpreters such as Kōgyū Yoshio translated and studied Dutch editions of early medical books, like Lorenz Heister's "Chirurgie" (Nürnberg, 1719), that illustrate the concept of transfusion. The oldest description of transfusion originating in Japan is a handwritten manuscript entitled "Bansui Sensi Chojutsu Shomoku" by Masamichi Nishijima, a student of Bansui Otsuki. It is a list of Otsuki's translated works. He described book names and chapter names in the manuscript, and when he finished translation of a chapter, he marked a circle on the chapter name. The transfusion chapter had a circle. That dates the earliest writing on transfusion in Japanese to 1804, shortly after the death of Kōgyū. Unfortunately, the manuscript translation no longer exists. In 1814, Shunzō Yoshio, grandson of Kōgyū, and in 1820, Tokki Koshimura, translated the figure legends of "Chirurgie." Soon afterwards, after the first report of transfusion from human-to-human by James Blundell in London in 1818, Western medical books published on the subject began to arrive. The works of Christoph Wilhelm Hufeland, Georg Friedrich Most and Carl Canstatt all mentioning transfusion, albeit without details, were translated by Kōan Ogata and Shinryō Tsuboi. During the Edo period, Japan was a closed country; only open to the Dutch through a tiny island in Nagasaki. But Japanese doctors in the Edo period learned about blood transfusion through Dutch-translated versions of Western medical Books. Transfusion began being practiced in Japan in 1919, almost exactly 100 years after the concept was introduced

  18. The Contemplative Life and the Teaching of the Humanities (United States)

    Stock, Brian


    Meditation nowadays plays a part in mind/body medicine and in some branches of educational psychology. In ancient and medieval times, these functions formed a part of the humanities curriculum as it was taught in philosophical schools, monastic communities, and universities. This article claims that it is by returning to a holistic view of the…

  19. Quality of Life Experienced by Human Capital: An Assessment of European Cities (United States)

    Morais, Paulo; Migueis, Vera L.; Camanho, Ana S.


    This paper aims to provide an assessment of urban quality of life (QoL) of European cities from the perspective of qualified human resources. The competitiveness of cities relies increasingly in their capacity to attract highly educated workers, as they are important assets for firms when choosing a location. Qualified human resources, on the…

  20. The Desymbolization of Human Life in Contemporary Mass Societies (United States)

    Vanderburg, Willem H.


    Judaism and Christianity, the religious traditions most influential on Western civilization, taught that the universe was created by the Word and that human beings were distinguished from all other animals by their use of words. What characterizes our age is a growing reliance on images as our words are being desymbolized. This desymbolization of…

  1. Prehistoric ceremonial warfare: beginning of institutionalized violence

    Czech Academy of Sciences Publication Activity Database

    Turek, Jan


    Roč. 13, č. 3 (2017), s. 535-548 ISSN 1555-8622 Institutional support: RVO:67985912 Keywords : human aggression * ceremonial warfare * archery symbolism * Neolithic * Chalcolithic * Europe Subject RIV: AC - Archeology, Anthropology, Ethnology OBOR OECD: Archaeology

  2. Childhood Programs and Practices in the First Decade of Life: A Human Capital Integration (United States)

    Reynolds, Arthur J., Ed.; Rolnick, Arthur J., Ed.; Englund, Michelle M., Ed.; Temple, Judy A., Ed.


    "Childhood Programs and Practices in the First Decade of Life" presents research findings on the effects of early childhood programs and practices in the first decade of life and their implications for policy development and reform. Leading scholars in the multidisciplinary field of human development and in early childhood learning…

  3. Tractatus; The beginning of Wittgenstein's therapeutic approach to philosophy

    Directory of Open Access Journals (Sweden)



    Full Text Available On the one hand, Wittgenstein considers philosophy as a generator of mental confusion, but on the other hand, he desires philosopher as a therapist. This two-sided attitude to philosophy begins with Tractatus and then admitting the various therapeutic methods, reaches to the second period of his life. Recently, the origins of Wittgenstein's therapeutic approach in Tractatus are neglected by most of his positivist commentators, instead, this approach have been followed in the second period of his thought, especially in Philosophical Investigations. In this essay, we have tried to clarify this obscurity and to indicate the roots of Wittgenstein's therapeutic approach in Tractatus. Since mentioning the "symptom" or symptoms of mental confusion resulting from philosophical thinking and stage of its "diagnosis" is considered as preparations of therapy, we, by emphasizing on the therapeutic value of clarity, will survey "symptom", "diagnosis" and finally Wittgenstein's therapeutic approach toward philosophy in Tractatus, and then we will point out some reasons causing negligence to Tractatus therapeutic approach. In this way, we will show that Wittgenstein, from the beginning of his philosophical thinking, has believed in this approach and in Philosophical Investigations he has just declared it in the everyday language. Here, we will also unveil restriction of Wittgenstein's therapeutic approach to philosophy.

  4. First Day of Life (United States)

    ... Educators Search English Español The First Day of Life KidsHealth / For Parents / The First Day of Life What's in this article? What Your Newborn Looks ... usually begin within the first few hours of life. Your Feelings Having a baby is a life- ...

  5. Frontiers of Life Sciences: The Human Exploration of the Moon and Mars (United States)

    North, Regina M.; Pellis, Neal R.


    The rapid development of the productive processes after World War II extended human settlements into new ecological niches. Advances in Life Sciences played a decisive role supporting the establishment of human presence in areas of the planet where human life could have not existed otherwise. The evolution of life support systems, and the fabrication of new materials and technologies has enabled humans to inhabit Polar Regions, ocean surfaces and depths; and to leave Earth and occupy Low Earth Orbit. By the end of the 20 th Century, stations in the Antarctic and Arctic, off shore oil platforms, submarines, and space stations had become the ultimate demonstration of human ability to engineer habitats at Earth extreme environments and outer space. As we enter the 21st Century, the next development of human settlements will occur through the exploration of the Moon, Mars, and beyond. The major risks of space exploration derive from long exposure of humans and other life systems to radiation, microgravity, isolation and confinement, dependence on artificial life support systems, and unknown effects (e.g., altered magnetic fields, ultrahigh vacuum on bacteria, fungi, etc.). Countermeasures will require a complete characterization of human and other biological systems adaptation processes. To sustain life in transit and on the surface of the Moon and Mars will require a balance of spacecraft, cargo, astronaut crews, and the use of in situ resources. Limitations on the number of crewmembers, payloads, and the barrenness of the terrain require a novel design for the capabilities needed in transit and at exploration outpost sites. The planned destinations have resources that may be accessed to produce materials, food, shelter, power, and to provide an environment compatible with successful occupation of longterm exploration sites. Once more, the advancements of Life Sciences will be essential for the design of interplanetary voyages and planetary surface operations. This

  6. Influence of quality of life on the state and development of human capital in Latvia

    Directory of Open Access Journals (Sweden)

    Zhanna Tsaurkubule


    Full Text Available Currently, the essence and forms of interrelation between human capital and quality of life are still insufficiently studied. Therefore, there is a need for defining general components of these categories and areas, where human capital interacts with quality of life. Today, Latvia has been developing in difficult conditions: the population is decreasing, emigration is growing, possibilities of employment are limited, and the income of residents is decreasing. All these factors reduce quality of life for the population and lead to the loss of human resources in the country. The existence of a problem stemming from the relationship between quality of life and human capital establishes the relevance of the research and determines its aim. The main contradiction is between the external positioning of the state as a country successfully overcoming crisis and the growth of internal crisis in the state, leading to the further impoverishment of the population, leading to an increased emigration of the working population of Latvia. The main research question is as follows: how to preserve human resources in the state? Based on an analysis of post-crisis socio-economic processes taking place in the society, recommendations are made to improve the socio-economic policy in ways that improve the welfare of the population of Latvia.


    African Journals Online (AJOL)


    University College Hospital, Ibadan alone therefore provided this needed outlet. A detailed search of the records showed a total of 25,167 surgical procedures of all categories and magnitudes from July 30, 1956 to October 24, 1962. They represent obstetrics and gynaecology, general surgery (including urologic, thoracic ...

  8. Beginning of time and end of physics

    International Nuclear Information System (INIS)

    Hawking, S.


    Under this title, two texts are gathered. The first text ( I s the End in Sight for Theoretical Physics ? ) is the inaugural lesson presented by Stephen Hawking in April 1980 at Cambridge when he took the Lucasian chair of Mathematics. The second text ( T he Edge of Space Time ) was published in 1989. Both deal with the origins and of the inevitable laws describing the universe. Can we - and how - succeed to a theory of universe from the most fundamental level, micro-physics, and can we applied this theory to the whole universe, to the macrocosm ? (A.B.)

  9. Life cycle human health impacts of 875 pesticides

    DEFF Research Database (Denmark)

    Fantke, Peter; Jolliet, Oliver


    human exposure to residues for a wide range of pesticide-crop combinations with latest findings of pesticide dissipation kinetics in crops and post-harvest food processing. Outcome is a set of intake fractions and characterization factors for 875 organic pesticides and six major food crops along...... and crop. Intake fractions are typically highest for lettuce and tomato and lowest for potato due to differences in application times before crop harvest and soil as additional barrier for uptake into potato tubers. Uncertainty in intake fractions is mainly associated with dissipation dynamics in crops...... pesticide-crop combination-specific characterization factors normalized to pesticide mass applied and provide default data for application times and loss due to post-harvest food processing. When using our data, we emphasize the need to consult current pesticide regulation, since each pesticide...

  10. Computer-Assisted Synthetic Planning: The End of the Beginning. (United States)

    Szymkuć, Sara; Gajewska, Ewa P; Klucznik, Tomasz; Molga, Karol; Dittwald, Piotr; Startek, Michał; Bajczyk, Michał; Grzybowski, Bartosz A


    Exactly half a century has passed since the launch of the first documented research project (1965 Dendral) on computer-assisted organic synthesis. Many more programs were created in the 1970s and 1980s but the enthusiasm of these pioneering days had largely dissipated by the 2000s, and the challenge of teaching the computer how to plan organic syntheses earned itself the reputation of a "mission impossible". This is quite curious given that, in the meantime, computers have "learned" many other skills that had been considered exclusive domains of human intellect and creativity-for example, machines can nowadays play chess better than human world champions and they can compose classical music pleasant to the human ear. Although there have been no similar feats in organic synthesis, this Review argues that to concede defeat would be premature. Indeed, bringing together the combination of modern computational power and algorithms from graph/network theory, chemical rules (with full stereo- and regiochemistry) coded in appropriate formats, and the elements of quantum mechanics, the machine can finally be "taught" how to plan syntheses of non-trivial organic molecules in a matter of seconds to minutes. The Review begins with an overview of some basic theoretical concepts essential for the big-data analysis of chemical syntheses. It progresses to the problem of optimizing pathways involving known reactions. It culminates with discussion of algorithms that allow for a completely de novo and fully automated design of syntheses leading to relatively complex targets, including those that have not been made before. Of course, there are still things to be improved, but computers are finally becoming relevant and helpful to the practice of organic-synthetic planning. Paraphrasing Churchill's famous words after the Allies' first major victory over the Axis forces in Africa, it is not the end, it is not even the beginning of the end, but it is the end of the beginning for the

  11. Beginning Teachers' Perception of Their Induction into the Teaching Profession (United States)

    Kidd, Lynda; Brown, Natalie; Fitzallen, Noleine


    Beginning teachers' induction into the teaching profession needs to be personally and professionally fulfilling, which is often not the case. The main objective of this mixed method study was to gain a deeper understanding of beginning teachers' experiences and the perceptions of their induction into the teaching profession and the support they…

  12. 42 CFR 407.25 - Beginning of entitlement: Individual enrollment. (United States)


    ..., entitlement began with the third month after the month in which the enrollment request was filed. (c... 42 Public Health 2 2010-10-01 2010-10-01 false Beginning of entitlement: Individual enrollment... Individual Enrollment and Entitlement for SMI § 407.25 Beginning of entitlement: Individual enrollment. The...

  13. Interrelationships of food safety and plant pathology: the life cycle of human pathogens on plants. (United States)

    Barak, Jeri D; Schroeder, Brenda K


    Bacterial food-borne pathogens use plants as vectors between animal hosts, all the while following the life cycle script of plant-associated bacteria. Similar to phytobacteria, Salmonella, pathogenic Escherichia coli, and cross-domain pathogens have a foothold in agricultural production areas. The commonality of environmental contamination translates to contact with plants. Because of the chronic absence of kill steps against human pathogens for fresh produce, arrival on plants leads to persistence and the risk of human illness. Significant research progress is revealing mechanisms used by human pathogens to colonize plants and important biological interactions between and among bacteria in planta. These findings articulate the difficulty of eliminating or reducing the pathogen from plants. The plant itself may be an untapped key to clean produce. This review highlights the life of human pathogens outside an animal host, focusing on the role of plants, and illustrates areas that are ripe for future investigation.

  14. Classroom Management: Beginning Teachers' Perceptions of Preparedness (United States)

    Woods, Sean A.


    Classroom management has been the focal point of many different studies and research projects. Unfortunately, it has also been cited as one of the top three reasons teachers leave the field of education not only today, but for the last 40 years (Berry, 2010). There is a need for an understanding of the implications of past classroom management…

  15. Punctuality of tram departing from beginning of tramstop

    Directory of Open Access Journals (Sweden)

    Adam MOLECKI


    Full Text Available The article presents results of researches of punctuality of tram departing from beginning of tramstops in Zagłębie Dąbrowskie. There were analyzed departures at classical tram lines, without light signaling of departing-time. There were inside of driver’s cabs sound signaling of departure. The departure’s punctuality problem from beginning of tramstops is very important to make tram traffic simulations. These ones let to optimalyze traffic engineering solutions.

  16. The Beginnings of Danish Speech Perception

    DEFF Research Database (Denmark)

    Østerbye, Torkil

    reductions of speech sounds evident in the pronunciation of the language. This book (originally a PhD thesis) consists of three studies based on the results of two experiments. The experiments were designed to provide knowledge of the perception of Danish speech sounds by Danish adults and infants......Little is known about the perception of speech sounds by native Danish listeners. However, the Danish sound system differs in several interesting ways from the sound systems of other languages. For instance, Danish is characterized, among other features, by a rich vowel inventory and by different......, in the light of the rich and complex Danish sound system. The first two studies report on native adults’ perception of Danish speech sounds in quiet and noise. The third study examined the development of language-specific perception in native Danish infants at 6, 9 and 12 months of age. The book points...

  17. Retrospective - the beginnings of the uranium industry

    International Nuclear Information System (INIS)



    This article is a historical perspective of the uranium industry, from the discovery of uranium in 1789 to the discovery of fission in 1939. It is the first in a series of articles. In this part of the series, the initial discovery of uranium is mentioned. Early ore discoveries, especially in the USA, are also noted, and the market conditions at the end of the 19th century are reviewed. Shortly after the discovery of radium in 1898 and natural radioactivity, the connection between uranium and radium was noted, and this is outlined in the article. Due to the intimate relationship between the two elements, radium product and radium markets are also reviewed

  18. Beginning and end of lunar mare volcanism

    International Nuclear Information System (INIS)

    Schultz, P.H.; Spudis, P.D.


    Having presented the inferred distribution and style of the early phases of mare volcanism, based on current evidence, it is suggested that certain regions of the Moon underwent two distinct pulses of igneous activity. Crater statistics for the post-Lichtenberg mare unit and other selected units are examined and it is concluded that mare volcanism extended to a time comparable with that of the Copernicus impact, or approximately 1 Myr BP. These reassessments of the oldest and youngest maria provide new constraints on geophysical models of the internal thermal history of the Moon. (U.K.)

  19. Tet: The Beginning of the End. (United States)

    Culver, David


    Discusses the Cold War and the U.S. policy of containment and its relationship to the Vietnam War. Traces the history of the Vietnam War, and analyzes U.S. military strategies in Vietnam. Details the events of Tet. Examines the repercussions of Tet on U.S. public opinion about President Johnson and the war. (RW)

  20. Installation of the LHC transfer lines begins

    CERN Multimedia

    Patrice Loïez


    The first of 700 magnets has been installed in one of the two transfer tunnels built to transfer the SPS beam into the LHC. The start of this first installation phase of the LHC transfer lines provides the opportunity to launch a new and highly original modular system for transporting and installing all kinds of magnets in very narrow tunnels. The system is based on very compact bogies, up to four of which can be coupled together to form a convoy. The wheels are fitted with individual motors enabling them to swivel through an angle of 90° and the convoy to move laterally. In this way the magnet is delivered directly to its installation point, but beneath the beamline. It is then raised into its final position in the beamline using air cushions, which form an integrated part of the transport system. Here we see the transport vehicle alongside the magnet supports. Visible in the background is the first magnet in place.

  1. Beginnings of the Industrial Revolution in England. (United States)

    Scrofani, E. Robert, Ed.

    These teacher-developed materials are designed to help educators integrate economic concepts into the teaching of history. The materials include readings on the Industrial Revolution in England and a series of activities that require students to analyze the impact of industrialization first on English peasant farmers, and then on workers in early…

  2. The Beginning and End of the Universe (United States)

    Gardner, Jonathan P.


    Cosmology is the scientific study of how the Universe began more than 13 billion years ago, how its properties have changed from that time to the present, and what its eventual fate might be. Observational cosmology uses telescopes like the Hubble to reach back in time to find the faint echoes of the Big Bang. In this lecture, I will give an overview of cosmology, highlighting the very rapid progress this field has made in the last decade, and the role that NASA space telescopes have played and will continue to play in the years to come. I will then focus on two of the most intriguing of those recent discoveries: inflation and dark energy. Our universe began in an extremely rapid accelerated expansion, called inflation, which removed all traces anything that may have existed before, flattened the geometry of space-time, and turned microscopic quantum fluctuations into the largest structures in the universe. At the present time, more than 70% of the mass-energy in the Universe consists of a mysterious substance called dark energy. The dark energy causes the expansion of the Universe to accelerate, and he will discuss the ways that we might be able to measure that acceleration more accurately, revealing the nature of the dark energy and learning the eventual fate of the Universe.

  3. [The beginnings of orthopedic surgery in Israel]. (United States)

    Tauber, Chanan


    In early mandatory Israel, orthopedics was mainly conservative, The first modern orthopedic surgeon was Ernst Spira from Czechoslovakia who established an orthopedic service at the Beilinson Hospital in Petah Tikva and left in 1948 to establish the Orthopedic Department and the Rehabilitation Center in Tel Hashomer, which treated the War of Independence casualties including amputees and victims of spinal cord injuries. A second orthopedic department was opened in Tel Hashomer by Shmuel Weissman who left in 1961 to open the Orthopedic Department at the Ichilov hospital in Tel Aviv. Shmuel Weissman became the first Chairman of Orthopedic Surgery at the Tel Aviv University medical school. In 1955, Myer Makin opened a modern orthopedic department in the Hadassah Hospital in Jerusalem and the Alyn Hospital for crippled children. In 1951, Assaf Harofeh Hospital opened the Department of Orthopedic Surgery headed by Anatol Axer who specialized in the treatment and rehabilitation of polio patients. The majority of the second generation of orthopedic department directors was trained by these four surgeons. Major developments in the 1960s and 1970s were the introduction of the AO system revolutionizing fracture treatment from conservative to operative treatment, the advent of total hip and knee replacements, Harrington instrumentation in spinal surgery and arthroscopy were major advances in orthopedic patient care brought to Israel by the aforementioned second generation of orthopedic surgeons. Hand surgery became an independent subspecialty of orthopedics and was lead by the internationally renowned hand surgeon, Isidore Kessler.

  4. Hydrogen energy - the end of the beginning

    International Nuclear Information System (INIS)

    Stuart, A. K.


    Financial barriers to the widespread use of hydrogen energy were the principal messages contained in this banquet address. These barriers include the cost for the hydrogen, cost for the supply infrastructure and the cost of developing and building the special vehicles and appliances to use hydrogen. Some hopeful signs that hydrogen energy is emerging include Ballard's buses, early fuel cell private vehicle refueling station and remote energy systems which will be commercialized within the next ten years. The optimism is based on the effects of deregulation of the electric utility industry in the US now spreading to Canada and other countries, the appearance of effective direct hydrogen fuel cell vehicles under strong industrial sponsorship, and the near-term availability of electrolysis for hydrogen production at a fraction of present capital cost. Each of these reasons for optimism were elaborated in some detail. However, the main force behind the hydrogen solution for transportation is the environmental benefit, i.e. the potential of some one billion automobiles around the world running on an environmentally benign fuel, and the potential effect of that fact on global warming. The likely effects of continuing as before is no longer considered a viable option even by the greatest of skeptics of greenhouse gas emissions, a fact that will make the demand for 'clean' vehicles progressively more pressing with the passage of time. By increasing the hydrogen-to-carbon ratio in upgrading heavy hydrocarbons, the petroleum industry itself is showing the way to factor global warming issues into process choices. By going one step further and obtaining the hydrogen from non-fossil sources, the environmental benefits will be multiplied several fold

  5. [The beginning of western medical education]. (United States)

    Kee, C D


    Our country had quite an advanced system of medical education during the era of the Koryo Kingdom, and during the Choson Dynasty, the Kyong Guk Dae Jon, in which a systematized medical education was clearly described, was compiled in the era of King Sejong. However, the educational system was not for Western medicine. Western medicine was first introduced to our country in the 9th year of King Injo (1631) when Chong Du Won, Yi Yong Jun, etc. returned from Yon Gyong (Beiuin) with Chik Bang Oe Gi. Knowledge of Western medicine was disseminated by Shil Hak (practical learning) scholars who read a translation in Chinese characters, of Chik Bang Oe Gi. Yi Ik (Song Ho), Yi Gyu Gyong (O ju), Choe Han Gi (Hye Gang), Chong Yak Yong (Ta San), etc., read books of Western medicine and introduced in writing the excellent theory of Western medicine. In addition, Yu Hyong Won (Pan Gye), Pak Ji Won (Yon Am), Pak Je Ga (Cho Jong), etc., showed much interest in Western medicine, but no writings by them about western medicine can be found. With the establishment of a treaty of amity with Japan in the 13th year of King Kojong (1876), followed by the succession of amity treaties with Western powers, foreigners including medical doctors were permitted to flow into this country. At that time, doctors Horace N. Allen, W. B. Scranton, John W. Heron, Rosetta Sherwood (Rosetta S. Hall), etc., came to Korea and inaugurated hospitals, where they taught Western medicine to Korean students. Dr. Horace N. Allen, with the permission of king Kojong, established Che Jung Won in April 1885, and in March 1886, he began at the hospital to provide education of Western medicine to Korean students who were recrutied by the Korean Government. However, the education was not conduted on a regular basis, only training them for work as assistants. This is considered to be the pioneer case of Western medical education in this country. Before that time, Japanese medical doctors came to Korea, but there are no

  6. Begin your partnership: the process of engagement. (United States)

    Jones, Loretta; Meade, Barbara; Forge, Nell; Moini, Moraya; Jones, Felica; Terry, Chrystene; Norris, Keith


    Community Partnered-Participatory Research (CPPR) is based on and utilizes community engagement as its central method and principle. In this chapter, we explain the key differences between engaging the community vs merely involving the community. The chapter also reviews the plan-do-action cycle of work that is used in each stage of CPPR. We define five key values of CPPR: respect for diversity, openness, equality, redirected power (empowerment), and an asset-based approach. In addition, we present 12 operational principles, which guide work throughout every stage of all CPPR initiatives.

  7. Installation of the LHC transfer lines begins

    CERN Multimedia

    Patrice Loïez


    The first of 700 magnets has been installed in one of the two transfer tunnels built to transfer the SPS beam into the LHC. The start of this first installation phase of the LHC transfer lines provides the opportunity to launch a new and highly original modular system for transporting and installing all kinds of magnets in very narrow tunnels. The system is based on very compact bogies, up to four of which can be coupled together to form a convoy. The wheels are fitted with individual motors enabling them to swivel through an angle of 90° and the convoy to move laterally. In this way the magnet is delivered directly to its installation point, but beneath the beamline. It is then raised into its final position in the beamline using air cushions, which form an integrated part of the transport system.Photo 01: Pictured with the newly installed magnet and transport system in the transfer line tunnel are (left to right) Volker Mertens, responsible for the LHC injection and transfer lines; personnel involved in tr...

  8. Installation of the LHC transfer lines begins

    CERN Multimedia

    Patrice Loïez


    The first of 700 magnets has been installed in one of the two transfer tunnels built to transfer the SPS beam into the LHC. The start of this first installation phase of the LHC transfer lines provides the opportunity to launch a new and highly original modular system for transporting and installing all kinds of magnets in very narrow tunnels. The system is based on very compact bogies, up to four of which can be coupled together to form a convoy. The wheels are fitted with individual motors enabling them to swivel through an angle of 90° and the convoy to move laterally. The first installation phase will continue until mid-April. In addition to the magnets, a beam dump facility also has to be installed. The second installation phase will take place later this year and should be completed in 2004, when the TI 8 transfer line is due to be tested. The second transfer line, in tunnel TI 2, should be ready in April 2007, once the LHC magnets have been transported through the downstream section of this tunnel. We...

  9. Installation of the LHC transfer lines begins

    CERN Multimedia

    Patrice Loïez


    The first of 700 magnets has been installed in one of the two transfer tunnels built to transfer the SPS beam into the LHC. The start of this first installation phase of the LHC transfer lines provides the opportunity to launch a new and highly original modular system for transporting and installing all kinds of magnets in very narrow tunnels. The system is based on very compact bogies, up to four of which can be coupled together to form a convoy. The wheels are fitted with individual motors enabling them to swivel through an angle of 90° and the convoy to move laterally. The first installation phase will continue until mid-April. In addition to the magnets, a beam dump facility also has to be installed. The second installation phase will take place later this year and should be completed in 2004, when the TI 8 transfer line is due to be tested. The second transfer line, in tunnel TI 2, should be ready in April 2007, once the LHC magnets have been transported through the downstream section of this tunnel.Pho...

  10. Installation of the LHC transfer lines begins

    CERN Multimedia

    Patrice Loïez


    The first of 700 magnets has been installed in one of the two transfer tunnels built to transfer the SPS beam into the LHC. The start of this first installation phase of the LHC transfer lines provides the opportunity to launch a new and highly original modular system for transporting and installing all kinds of magnets in very narrow tunnels. The system is based on very compact bogies, up to four of which can be coupled together to form a convoy. The wheels are fitted with individual motors enabling them to swivel through an angle of 90° and the convoy to move laterally. In this way the magnet is delivered directly to its installation point, but beneath the beamline. It is then raised into its final position in the beamline using air cushions, which form an integrated part of the transport system.Photos 01, 02: Pictured with the newly installed magnet and transport system in the transfer line tunnel are LHC project leader Lyn Evans (second left, white helmet); Volker Mertens, responsible for the LHC injecti...

  11. Installation of the LHC transfer lines begins

    CERN Multimedia

    Patrice Loïez


    The first of 700 magnets has been installed in one of the two transfer tunnels built to transfer the SPS beam into the LHC. The start of this first installation phase of the LHC transfer lines provides the opportunity to launch a new and highly original modular system for transporting and installing all kinds of magnets in very narrow tunnels. The system is based on very compact bogies, up to four of which can be coupled together to form a convoy. The wheels are fitted with individual motors enabling them to swivel through an angle of 90° and the convoy to move laterally. The first installation phase will continue until mid-April. In addition to the magnets, a beam dump facility also has to be installed. The second installation phase will take place later this year and should be completed in 2004, when the TI 8 transfer line is due to be tested. The second transfer line, in tunnel TI 2, should be ready in April 2007, once the LHC magnets have been transported through the downstream section of this tunnel. Th...

  12. Higgs: the beginning of the exploration

    CERN Multimedia

    Antonella Del Rosso


    Even in the most specialized circles, the new particle discovered in July is not called the “Higgs boson” yet. Physicists still hesitate to give it this name because they want to be sure that its properties fit with those predicted by the Higgs theory. This week, at the HCP conference in Kyoto, CMS and ATLAS presented their latest results: a more refined data analysis has produced a more accurate value of the mass of the particle and has started to show decay channels never before observed.   Since July, both ATLAS and CMS have been working on extending the capabilities of their data analysis. The large teams of physicists have studied in even greater detail all the signals and the information that can be extracted from the data. Following this collective effort, both collaborations have recently presented an update on the mass of the new particle, together with several new measurements which are starting to unveil its properties. ATLAS has analysed a large sample of 13 fb-1 ...

  13. Installation of the LHC transfer lines begins

    CERN Multimedia


    On 19 February, the very first magnet was installed in one of the two tunnels that will house the transfer lines leading to the LHC. This magnet, recycled from a previous facility, was transported and positioned using a novel system designed for conveying large objects through narrow tunnels.

  14. The Beginnings of X-ray Crystallography

    Indian Academy of Sciences (India)

    IAS Admin

    broke his arm when he was 5 years old and his father used the newly discovered Rontgen-rays. (X-rays) and his experimental equipment to examine the broken arm, which is the first recorded surgical use of X-rays in Australia. William Lawrence Bragg married Alice Hopkinson (1899–. 1989) in 1921, with whom he had four ...

  15. Social Media: Human Life

    Directory of Open Access Journals (Sweden)

    Nick Couldry


    Full Text Available This article explores the idea that research into media communications and information has recently undergone a normative turn as more and more writers reflect on the ever deeper embedding of our lives in media, and the possible costs that this entails. Possible ways forward for deepening and addressing this normative turn are explored, based on the particular contribution to media and communications research of social theory.


    Directory of Open Access Journals (Sweden)

    T. H. Usmanova


    Full Text Available Relevance of the chosen subject is caused by the current state and problems of development of a human capital and potential. The existing changes of the current legislation and a tendency of development of a human capital in Russia in developed countries allow to subject to doubt efficiency of planning of economic and social programs in the country. Also relevance of article is caused by the fact that in the conditions of a transitional economy and integration of economy into the world economy many countries create quality of life of the population according to standards and there is a need of revaluation of values regarding development of a human capital in Russia within the world device.In the first part of article the overview of historical aspects of planning of a human capital and the analysis of high budget revenues becomes. In article it is shown that expenses aren't effectively distributed on regional equalization and on social needs, that is on development of a welfare and a human capital and potential in the country.The second part of article describes one of manifestations of the quality level of life, that is the Minimum Wage (MW which is the main indicator for charge of temporary disability benefits, pension accrual, unemployment benefits, etc.The third part of article reflects the directions of development of innovative management: improvement of quality of life and a human capital where emphasis on need of preparation intellectual the oriented specialists is placed.The purpose/goal .The purpose of article is disclosure, comparison of features, and also determinations of criteria of management of innovative development of quality of life and a human capital in the Russian Federation.Methodology. The methodology of the solution of objectives is based on use of a method of a dialectic research, methods of the economic analysis, forecasting, the situation and system analysis, expert evaluations and the analysis of empirical data

  17. Beginning at the beginning: Recall order and the number of words to be recalled. (United States)

    Tan, Lydia; Ward, Geoff; Paulauskaite, Laura; Markou, Maria


    When participants are asked to recall a short list of words in any order that they like, they tend to initiate recall with the first list item and proceed in forward order, even when this is not a task requirement. The current research examined whether this tendency might be influenced by varying the number of items that are to be recalled. In 3 experiments, participants were presented with short lists of between 4 and 6 words and instructed to recall 1, 2, 3, or all of the items from the lists. Data were collected using immediate free recall (IFR, Experiment 1), immediate serial recall (ISR, Experiment 2), and a variant of ISR that we call ISR-free (Experiment 3), in which participants had to recall words in their correct serial positions but were free to output the words in any order. For all 3 tasks, the tendency to begin recall with the first list item occurred only when participants were required to recall as many items from the list as they could. When participants were asked to recall only 1 or 2 items, they tended to initiate recall with end-of-list items. It is argued that these findings show for the first time a manipulation that eliminates the initial tendency to recall in forward order, provide some support for recency-based accounts of IFR and help explain differences between single-response and multiple-response immediate memory tasks. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  18. The factor harmful to the quality of human life--shift-work. (United States)

    Strzemecka, Joanna; Pencuła, Marcin; Owoc, Alfred; Szot, Wojciech; Strzemecka, Ewa; Jabłoński, Mirosław; Bojar, Iwona


    The system of human activity, which is established by genetics and regulated by outer and inner factors, is associated with many characteristics which maintain the body in the best condition and ensure appropriate life quality. To evaluate of life quality among male shift-workers. Research based on a self-devised questionnaire, conducted among 700 shift-workers, followed by statistical analysis of the results. Nearly a half of respondents (43.00%) reported that shift-work influences the quality of their family life. Remarkably, such an opinion was often stated by people with children (46.01%) pwork negatively influence their sexual life (31.14%). It was shown that shift-work negatively influences the respondents' life quality in the form of deterioration of the quality of family life; the respondents, regardless of marital status, age and having children, most often complained about the lack of contact with the family and irregular eating with them; negative influence on sexual life, which was the case in one-third of respondents. In order to encourage healthy behaviour and increase the quality of life of people performing shift-work, training and programmes should be introduced. These would help shift- workers to adjust their work time to their family and social life.

  19. Comparative Human Health Impact Assessment of Engineered Nanomaterials in the Framework of Life Cycle Assessment. (United States)

    Fransman, Wouter; Buist, Harrie; Kuijpers, Eelco; Walser, Tobias; Meyer, David; Zondervan-van den Beuken, Esther; Westerhout, Joost; Klein Entink, Rinke H; Brouwer, Derk H


    For safe innovation, knowledge on potential human health impacts is essential. Ideally, these impacts are considered within a larger life-cycle-based context to support sustainable development of new applications and products. A methodological framework that accounts for human health impacts caused by inhalation of engineered nanomaterials (ENMs) in an indoor air environment has been previously developed. The objectives of this study are as follows: (i) evaluate the feasibility of applying the CF framework for NP exposure in the workplace based on currently available data; and (ii) supplement any resulting knowledge gaps with methods and data from the life cycle approach and human risk assessment (LICARA) project to develop a modified case-specific version of the framework that will enable near-term inclusion of NP human health impacts in life cycle assessment (LCA) using a case study involving nanoscale titanium dioxide (nanoTiO 2 ). The intent is to enhance typical LCA with elements of regulatory risk assessment, including its more detailed measure of uncertainty. The proof-of-principle demonstration of the framework highlighted the lack of available data for both the workplace emissions and human health effects of ENMs that is needed to calculate generalizable characterization factors using common human health impact assessment practices in LCA. The alternative approach of using intake fractions derived from workplace air concentration measurements and effect factors based on best-available toxicity data supported the current case-by-case approach for assessing the human health life cycle impacts of ENMs. Ultimately, the proposed framework and calculations demonstrate the potential utility of integrating elements of risk assessment with LCA for ENMs once the data are available. © 2016 Society for Risk Analysis.

  20. Regulation of human life histories: the role of the inflammatory host response. (United States)

    Van Bodegom, David; May, Linda; Meij, Hans J; Westendorp, Rudi G J


    Most species with a long life span have few offspring while species with a short life span have many offspring. This evolutionary trade-off between fertility and body maintenance, based on the theory of r/K-selection, is a central theme in the theory of life history regulation. This trade-off is not only found between various species but also between individuals within one species. There is accumulating evidence for this trade-off in humans. We hypothesize that the innate immune system is a critical factor skewing an individual into the direction of either a high fertility or better maintenance strategy. As over thousands of years human survival has been highly dependent on resistance to infectious diseases, genetic adaptations resulting in inflammatory responses were favored. An inflammatory host response is critical to fight infection necessary to survive up to reproductive age. An inflammatory host response is also negatively associated with fertility and can explain for the trade-off between fertility and body maintenance. After human reproductive age, these inflammatory responses contribute also to development of chronic degenerative diseases. These will especially become apparent in affluent societies where the majority of individuals reach old age. Identifying the inflammatory host response as a critical factor both in the regulation of human life histories and in the occurrence of chronic diseases at old age implies means for intervention allowing individuals to live healthier for longer.

  1. Human health impacts in the life cycle of future European electricity generation

    International Nuclear Information System (INIS)

    Treyer, Karin; Bauer, Christian; Simons, Andrew


    This paper presents Life Cycle Assessment (LCA) based quantification of the potential human health impacts (HHI) of base-load power generation technologies for the year 2030. Cumulative Greenhouse Gas (GHG) emissions per kWh electricity produced are shown in order to provide the basis for comparison with existing literature. Minimising negative impacts on human health is one of the key elements of policy making towards sustainable development: besides their direct impacts on quality of life, HHI also trigger other impacts, e.g. external costs in the health care system. These HHI are measured using the Life Cycle Impact Assessment (LCIA) methods “ReCiPe” with its three different perspectives and “IMPACT2002+”. Total HHI as well as the shares of the contributing damage categories vary largely between these perspectives and methods. Impacts due to climate change, human toxicity, and particulate matter formation are the main contributors to total HHI. Independently of the perspective chosen, the overall impacts on human health from nuclear power and renewables are substantially lower than those caused by coal power, while natural gas can have lower HHI than nuclear and some renewables. Fossil fuel combustion as well as coal, uranium and metal mining are the life cycle stages generating the highest HHI. - Highlights: • Life cycle human health impacts (HHI) due to electricity production are analysed. • Results are shown for the three ReCiPe perspectives and IMPACT2002+LCIA method. • Total HHI of nuclear and renewables are much below those of fossil technologies. • Climate change and human toxicity contribute most to total HHI. • Fossil fuel combustion and coal mining are the most polluting life cycle stages

  2. A Symbiosis of Islamic Principles and Basic Human Values on Work and Life

    Directory of Open Access Journals (Sweden)

    Rokis Rohaiza


    Full Text Available The article discusses some basic issues on work and life based on Islamic and non-religious principles. Work and life are inseparable facets of and for human existence. Work derives from the demands of life, and thus it becomes a responsibility for every individual person. The article attempts to relate some highlighted Qur’anic verses and Hadith with basic occupational values such as honesty, modesty and innovativeness, among others, at workplaces. In the end, it makes an effort to understand the working of the subconscious mind on work to make life worthwhile. The plan for this article is to lay emphasis that the presence of human beings, which includes their mind, energy and whatever they can offer in the forms of work, benefits all. In such a case, not only those humans may be seen as successful in fulfilling the work-needs, but also victorious in completing the life-demands as human beings. “Virtuous workplace” is the most ideal platform for such purpose.

  3. Search begins for missing radiation sources in Republic of Georgia

    International Nuclear Information System (INIS)


    An international team assembled by the IAEA will begin a search today for two abandoned Strontium 90 generators in a ca. 550 sq. km area of Western Georgia. About 80 people will take part in the two-week search beginning on Monday, 10 June. Radiation experts for the IAEA, India, France, Turkey and the U.S. are also part of the team, which will set out on horseback, foot and by car. The second phase - an aerial and road survey covering different territory - is scheduled to begin in early September. The objective is to locate and recover other known or suspected orphaned radioactive sources in the country

  4. Influence of Indoor Hygrothermal Conditions on Human Quality of Life in Social Housing. (United States)

    Soares, Sara; Fraga, Silvia; Delgado, Joao M P Q; Ramos, Nuno M M


    Modern societies spend most of their time indoors, namely at home, and the indoor environment quality turns out to be a crucial factor to health, quality of life and well-being of the residents. The present study aims to understand how indoor environment relates with quality of life and how improving housing conditions impacts on individuals' health. This study case will rely on the following assessments in both rehabilitated and non-rehabilitated social housing: i) field measurements, in social dwellings (namely temperature, relative humidity, carbon dioxide concentration, air velocity, air change rate, level of mould spores and energy consumption); ii) residents' questionnaires on social, demogaphic, behavioural, health characteristics and quality of life. Also, iii) qualitative interviews performed with social housing residents from the rehabilitated houses, addressing the self-perception of living conditions and their influence in health status and quality of life. All the collected information will be combined and analysed in order to achieve the main objective. It is expected to define a Predicted Human Life Quality (PHLQ) index, that combines physical parameters describing the indoor environment measured through engineering techniques with residents' and neighbourhood quality of life characteristics assessed by health questionnaires. Improvement in social housing should be related with better health indicators and the new index might be an important tool contributing to enhance quality of life of the residents. Significance for public healthThis study will contribute to understand how indoor environment relates with quality of life and how improving housing conditions impacts on individuals' health, in social housing neighbourhoods. As so, it is important to share the undertaken methodology carried out by a multidisciplinary team, in order to allow other researchers following comparable studies to adopt a similar approach. The case study results will allow

  5. Belief in the Immortality of the Human Soul and a Future Life ...

    African Journals Online (AJOL)

    The paper is a reflection on ancient Basotho's conception of death. For ancient Basotho, death pertains to animals and other animate things, not humans. They believe in a future life. It is argued that it is unfair to regard a belief on the resurrection as meaningless simply because it does not pass either the verifiability criterion ...

  6. Blood Lifestyle: Externalizing the Cost of Human Life (United States)

    Model, David


    To build postsecondary institutions that educate responsible citizens as well as competent employees and consumers, it is important that people must teach and learn themselves about the context--domestic and global--in which work is to be done, and the purposes which economic and technological development serve. One aspect of that context is the…

  7. A Detection Device for the Signs of Human Life in Accident (United States)

    Ning, Li; Ruilan, Zhang; Jian, Liu; Ruirui, Cheng; Yuhong, Diao


    A detection device for the signs of human life in accidents is a device used in emergency situations, such as the crash site. the scene of natural disasters, the battlefield ruins. it designed to detect the life signs of the distress under the injured ambulance vital signs devices. The device can on human vital signs, including pulse, respiration physiological signals to make rapid and accurate response. After some calculations, and after contrast to normal human physiological parameters given warning signals, in order for them to make timely ambulance judgment. In this case the device is required to do gymnastics convenience, ease of movement, power and detection of small flexible easy realization. This device has the maximum protection of the wounded safety significance.

  8. The cooperative economy of food: Its effect on human life history and physiology. (United States)

    Kramer, Karen L


    The human diet has undergone substantial modifications since the emergence of modern humans and varies considerably in today's traditional societies. Despite these changes and cross-cultural differences, the human diet can be characterized by several common elements. These include diverse, high quality foods, technological complexity to acquire and process food, and the establishment of home bases for storage, processing and consumption. Together these aspects of the human diet challenge any one individual to independently meet all of his or her daily caloric needs. Humans solve this challenge through food sharing, labor exchange and the division of labor. The cooperative nature of the human diet is associated with downstream effects on our life history and physiology. This paper overviews the constellation of traits that likely led to a cooperative economy of food, and draws on ethnographic examples to illustrate its effects on human life history and physiology. Two detailed examples using body composition, time allocation and food acquisition data show how cooperation among Savanna Pumé hunter-gatherers affects activity levels, sexual dimorphism in body fat, maturational pace and age at first birth. Copyright © 2018. Published by Elsevier Inc.

  9. On the development of life prediction methodologies for the failure of human teeth

    Energy Technology Data Exchange (ETDEWEB)

    Nalla, R.K.; Imbeni, V.; Kinney, J.H.; Marshall, S.J.; Ritchie, R.O.


    Human dentin is known to be susceptible to failure under cyclic loading. Surprisingly, there are few reports that quantify the effect of such loading, considering the fact that a typical tooth experiences a million or so loading cycles annually. In the present study, a systematic investigation is described of the effects of prolonged cyclic loading on human dentin in a simulated physiological environment. In vitro stress-life (S/N) data are discussed in the context of possible mechanisms of fatigue damage and failure.

  10. Life extension by calorie restriction in humans. (United States)

    Everitt, Arthur V; Le Couteur, David G


    Long-term reduction in energy intake in the diet (calorie restriction [CR]) extends the life of the laboratory rat by about 25%. However, in humans there are no life-long studies of CR, but only short-term trials which indicate that 20% CR acting over periods of 2-6 years is associated with reduced body weight, blood pressure, blood cholesterol, and blood glucose--risk factors for the major killer diseases of cardiovascular disease and diabetes. In addition, recent research has shown that CR for 6 months is able to improve biomarkers for longevity (deep body temperature and plasma insulin) and thus should increase life expectancy. The magnitude of the life-extension effect of CR in humans can only be estimated. The Okinawans, the longest-lived people on earth, consume 40% fewer calories than the Americans and live only 4 years longer. Similarly, women in United States consume 25% fewer calories than men and live 5 years longer. From the survival studies of overweight and obese people, it is estimated that long-term CR to prevent excessive weight gain could add only 3-13 years to life expectancy. Thus the effects of CR on human life extension are probably much smaller than those achieved by medical and public health interventions, which have extended life by about 30 years in developed countries in the 20th century, by greatly reducing deaths from infections, accidents, and cardiovascular disease.

  11. Alteration of a human intestinal microbiota under extreme life environment in the Antarctica. (United States)

    Jin, Jong-Sik; Touyama, Mutsumi; Yamada, Shin; Yamazaki, Takashi; Benno, Yoshimi


    The human intestinal microbiota (HIM) settles from birth and continues to change phenotype by some factors (e.g. host's diet) throughout life. However, the effect of extreme life environment on human HIM composition is not well known. To understand HIM fluctuation under extreme life environment in humans, fecal samples were collected from six Japanese men on a long Antarctic expedition. They explored Antarctica for 3 months and collected their fecal samples at once-monthly intervals. Using terminal restriction fragment length polymorphism (T-RFLP) and real time polymerase chain reaction (PCR) analysis, the composition of HIM in six subjects was investigated. Three subjects presented restoration of HIM after the expedition compared versus before and during the expedition. Two thirds samples collected during the expedition belonged to the same cluster in dendrogram. However, all through the expedition, T-RFLP patterns showed interindividual variability. Especially, Bifidobacterium spp. showed a tendency to decrease during and restore after the expedition. A reduction of Bifidobacterium spp. was observed in five subjects the first 1 month of the expedition. Bacteroides thetaiotaomicron, which is thought to proliferate during emotional stress, significantly decreased in one subject, indicating that other factors in addition to emotional stress may affect the composition of HIM in this study. These findings could be helpful to understand the effect of extreme life environment on HIM.

  12. Morphological and histomorphometric evaluation of the ventral rectus sheath of the rectus abdominis muscle, fascia lata and pectoral fascia. The beginning of a morphological information bank of human fascias. (United States)

    Morales-Avalos, Rodolfo; Soto-Domínguez, Adolfo; García-Juárez, Jaime; Cardenas-Serna, Marcela; Esparza-Hernández, Claudia N; Carreño-Salcedo, Sofía Alejandra; Montes-de-Oca-Luna, Roberto; Loera-Arias, María de Jesús; Saucedo-Cárdenas, Odila; Elizondo-Omaña, Rodrigo E; Guzmán-López, Santos


    The aim of this study was to characterize and compare the morphological and histomorphometric characteristics of the pectoral fascia, fascia lata and ventral rectus sheath. Twenty cadaveric samples of these fascias were analyzed and stained with hematoxylin and eosin, orcein, Van Gieson, Masson's trichrome and Verhoeff¨s stain (1200 slides in total). Morphological evaluation, semiquantitative, morphometric and microdensitometric analysis of elastic fibers present in each of the tissues and a morphometrical analysis of tissue thickness were performed. The mean value of the pectoral fascia thickness was 612±68.13 μm; 84±246 μm for the fascia lata and 584±92 μm for the ventral rectus sheath. The area occupied by the elastic fibers in the pectoral fascia was 12.24±5.84%; 6,54±3.85% for the fascia lata and 11.11±5.26% for the ventral rectus sheath. There were no statistically significant differences when comparing the mean values between the pectoral fascia and the ventral rectus sheath (p=0.07). There were statistically significant differences when comparing the fascia lata to the pectoral fascia and the ventral rectus sheath (p≤0.001). This study reports other morphological characteristics not described in previous histological studies of the analyzed tissues. The results of the morphometric and densitometric analysis in this study reveal that the fascia lata has the fewest elastic fibers of all the tissues analyzed, and the pectoral fascia has the most. These results will be useful for the beginning of a morphological information bank of human fascias.

  13. IVF culture medium affects post-natal weight in humans during the first 2 years of life

    NARCIS (Netherlands)

    Kleijkers, Sander H. M.; van Montfoort, Aafke P. A.; Smits, Luc J. M.; Viechtbauer, Wolfgang; Roseboom, Tessa J.; Nelissen, Ewka C. M.; Coonen, Edith; Derhaag, Josien G.; Bastings, Lobke; Schreurs, Inge E. L.; Evers, Johannes L. H.; Dumoulin, John C. M.


    Is post-natal growth during the first 2 years of life in IVF singletons affected by type of medium used for culturing human embryos during an IVF treatment? The in vitro culture of human embryos in medium from Cook resulted in singletons with a lower weight during the first 2 years of life compared

  14. Biology and data-intensive scientific discovery in the beginning of the 21st century. (United States)

    Smith, Arnold; Balazinska, Magdalena; Baru, Chaitan; Gomelsky, Mark; McLennan, Michael; Rose, Lynn; Smith, Burton; Stewart, Elizabeth; Kolker, Eugene


    The life sciences are poised at the beginning of a paradigm-changing evolution in the way scientific questions are answered. Data-Intensive Science (DIS) promise to provide new ways of approaching scientific challenges and answering questions. This article is a summary of the life sciences issues and challenges as discussed in the DIS workshop in Seattle, September 19-20, 2010. © Mary Ann Liebert, Inc.

  15. The influence of the level of physical activity and human development in the quality of life in survivors of stroke


    Aidar, Felipe J; de Oliveira, Ricardo J; Silva, Ant?nio J; de Matos, Dihogo G; Carneiro, Andr? L; Garrido, Nuno; Hickner, Robert C; Reis, Victor M


    Abstract Background The association between physical activity and quality of life in stroke survivors has not been analyzed within a framework related to the human development index. This study aimed to identify differences in physical activity level and in the quality of life of stroke survivors in two cities differing in economic aspects of the human development index. Methods Two groups of subjects who had suffered a stroke at least a year prior to testing and showed hemiplegia or hemipare...

  16. Assessment of Human Bio-Behavior During Gait Process Using LifeMOD Software

    Directory of Open Access Journals (Sweden)

    Liliana Rogozea


    Full Text Available In this paper we present a set of observations concerning the
    analysis and assessment of human bio-behavior during gait process. In the first part of the paper the fundamental and theoretical considerations of the gait process are approached and aspects connected to malfunctions are expressed. In the second part of the paper we present the modeling methodology using
    the LifeMOD software, while in the third part the results and conclusions are presented.

  17. Work-life Balance Decision-making of Norwegian Students: Implications for Human Resources Management

    Directory of Open Access Journals (Sweden)

    Remigiusz Gawlik


    Full Text Available Objective: The paper aims at identifying and assessing the significance of work-life balance determinants between the Youth of highly developed societies and its implications for human resources management on the example of Norway. Research Design & Methods: The research target group consists of 236 respondents recruited among Norwegian tertiary education students. It employed literature analysis, two-stage exploratory research: direct individual in-depth interviews, survey based on a self-administered, web-based questionnaire with single-answer, limited choice qualitative & quantitative, as well as explanatory research (informal moderated group discussions. Findings: The research on perceptions of determinants of quality of life and attractiveness of life strategies shows that in a country with relatively high socio-economic development level, such as Norway, differences in rankings do exist. They can be observed in relevance to both material and non-material QoL determinants. Implications & Recommendations: The study revealed a need for deeper research on individually driven early decision-making of future employees and entrepreneurs. This will result in closer modelling of socio-economic phenomena, including more accurate adaptation to trends on the labour market and creation of new business models. Contribution & Value Added: Research value added comes from the comparison of perceptions of quality of life determinants between countries at various stages of socio-economic development and its implications for human resource management.

  18. Overview of EPA CSS Intramural Research on Life Cycle and Human Exposure Modeling (United States)

    Improved human exposure modeling in life cycle assessmentsModeling and assessment for chemicals/products with less extensive dataMore rapid and higher throughput assessmentsLife Cycle-Human Exposure Modeling (LC-HEM) tool usable by Offices/Regions and by external stakeholders

  19. Increasing cell culture population doublings for long-term growth of finite life span human cell cultures (United States)

    Stampfer, Martha R; Garbe, James C


    Cell culture media formulations for culturing human epithelial cells are herein described. Also described are methods of increasing population doublings in a cell culture of finite life span human epithelial cells and prolonging the life span of human cell cultures. Using the cell culture media disclosed alone and in combination with addition to the cell culture of a compound associated with anti-stress activity achieves extended growth of pre-stasis cells and increased population doublings and life span in human epithelial cell cultures.

  20. Regulatory single nucleotide polymorphisms at the beginning of ...

    Indian Academy of Sciences (India)

    There are two regulatory single nucleotide polymorphisms (rSNPs) at the beginning of the second intron of the mouse - gene that are strongly associated with lung cancer susceptibility. We performed functional analysis of three SNPs (rs12228277: T>A, rs12226937: G>A, and rs61761074: T>G) located in the same ...

  1. What do we mean by Human-Centered Design of Life-Critical Systems? (United States)

    Boy, Guy A


    Human-centered design is not a new approach to design. Aerospace is a good example of a life-critical systems domain where participatory design was fully integrated, involving experimental test pilots and design engineers as well as many other actors of the aerospace engineering community. This paper provides six topics that are currently part of the requirements of the Ph.D. Program in Human-Centered Design of the Florida Institute of Technology (FIT.) This Human-Centered Design program offers principles, methods and tools that support human-centered sustainable products such as mission or process control environments, cockpits and hospital operating rooms. It supports education and training of design thinkers who are natural leaders, and understand complex relationships among technology, organizations and people. We all need to understand what we want to do with technology, how we should organize ourselves to a better life and finally find out whom we are and have become. Human-centered design is being developed for all these reasons and issues.

  2. In the Beginning-The Birth of a Living Universe

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 2; Issue 6. In the Beginning — The Birth of a Living Universe Evolutionary Ripples. S Krishnaswamy. Book Review Volume 2 Issue 6 June 1997 pp 93-96. Fulltext. Click here to view fulltext PDF. Permanent link:

  3. Beginning science teachers' performances: Assessment in times of reform (United States)

    Budzinsky, Fie K.


    The current reform in science education and the research on effective teaching and student learning have reinforced the importance of teacher competency. To better measure performances in the teaching of science, performance assessment has been added to Connecticut's licensure process for beginning science teachers. Teaching portfolios are used to document teaching and learning over time. Portfolios, however, are not without problems. One of the major concerns with the portfolio assessment process is its subjectivity. Assessors may not have opportunities to ask clarifying or follow-up questions to enhance the interpretation of a teacher's performance. In addition, portfolios often contain components based on self-documentation, which are subjective. Furthermore, the use of portfolios raises test equity issues. These concerns present challenges for persons in charge of establishing the validity of a portfolio-based licensure process. In high-stakes decision processes, such as teaching licensure, the validity of the assessment instruments must be studied. The primary purpose of this study was to explore the criterion-related validity of the Connecticut State Department of Education's Beginning Science Teaching Portfolio by comparing the interpretations of performances from science teaching portfolios to those derived from another assessment method, the Expert Science Teaching Educational and Evaluation Model, (ESTEEM). The analysis of correlations between the Beginning Science Teaching Portfolio and ESTEEM instrument scores was the primary method for establishing support for validity. The results indicated moderate correlations between all Beginning Science Teaching Portfolio and ESTEEM category and total variables. Multiple regression was used to examine whether differences existed in beginning science teachers' performances based on gender, poverty group, school level, and science discipline taught. None of these variables significantly contributed to the

  4. Facets of a life

    International Nuclear Information System (INIS)

    Sakharov, A.


    This book is physicist's tribute to Andrei Dmitrievich Sakharov. This out-standing person - a talented physicist and citizen of the world - has played an extremely important role in the deep-going changes occurring in our country. His name belongs to history. Accounts of people who met him and are capable of assessing his scientific work and public activism are just beginning to pour in. In our view, this collection of reminiscences is only a small but essential, contribution to the restoration of A.D. Sakharov's image. Most of the authors, physicists, mathematicians and computer scientists from many countries, knew him as a colleague. To a varying extent, they were a part of his difficult life. This is what this collection is about. Both professional and humanistic facets of his life are described. The book begins with the texts published when he ran for a post of a people's deputy of the USSR and the biographical note printed in the Uspekhi Fizicheskikh Nauk journal after his death. They are mutually complementary for the former contains a short description of his biography and human rights activism, and the latter emphasizes Sakharov's scientific work. The authors' index contains basic data about them. The Annexes contain some previously unpublished Sakharov's documents. Among them there is 'The Letter to Soviet Scientists' with an appeal which, unfortunately, did not get the support it deserved

  5. Life after a Humanities Degree (United States)

    Masola, Athambile


    This article explores the experiences of a humanities graduate after leaving the academy. The author considers her own education in light of the historical changes in South Africa's education system. The article is a personal account of the questions and challenges encountered in choosing a humanities degree in a context where a tertiary education…

  6. Understanding beginning teacher induction: A contextualized examination of best practice

    Directory of Open Access Journals (Sweden)

    Sean Kearney


    Full Text Available The problems that teachers face early in their careers are a major factor in growing rates of attrition among neophyte teachers. According to the Organisation for Economic Co-operation and Development, high rates of attrition, coupled with and aging teacher population in many countries in the developed world, may cause a teacher shortage crisis in coming years. Beginning teacher induction is an imperative process in acculturating teachers to their new careers and helping them overcome the hardships of teaching and the accreditation process. While induction practices have become more common in recent years, there are still no mandated structures for inducting teachers into the profession throughout Australia. This article reviews a number of international induction programs, which have been successful in supporting beginning teachers and curbing attrition rates, to emphasize why many programs are inadequate at meeting the needs of beginning teachers. The review proposes a definition for induction to better understand common misconceptions and highlights best practice induction as a way to retain quality teachers in the profession and help ameliorate conditions for beginning teachers. Finally, recommendations are made, specifically in the Australian context, which could help to improve induction practices to better acculturate neophyte teachers to their profession.

  7. Mastering Inflectional Suffixes: A Longitudinal Study of Beginning Writers' Spellings (United States)

    Turnbull, Kathryn; Deacon, S. Helene; Bird, Elizabeth Kay-Raining


    This study tracked the order in which ten beginning spellers (M age = 5 ; 05; SD = 0.21 years) mastered the correct spellings of common inflectional suffixes in English. Spellings from children's journals from kindergarten and grade 1 were coded. An inflectional suffix was judged to be mastered when children spelled it accurately in 90 percent of…

  8. Development of PBPK models for PFOA and PFOS for human pregnancy and lactation life stages. (United States)

    Loccisano, Anne E; Longnecker, Matthew P; Campbell, Jerry L; Andersen, Melvin E; Clewell, Harvey J


    Perfluoroalkyl acid carboxylates and sulfonates (PFAA) have many consumer and industrial applications. Developmental toxicity studies in animals have raised concern about potential reproductive/developmental effects of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS); however, in humans conflicting results have been reported for associations between maternal PFAA levels and these outcomes. Risk assessments and interpretation of available human data during gestation and lactation are hindered due to lack of a framework for understanding and estimating maternal, fetal, and neonatal pharmacokinetics (PK). Physiologically based pharmacokinetic (PBPK) models were developed for PFOA and PFOS for the gestation and lactation life stages in humans to understand how the physiological changes associated with development affect pharmacokinetics of these compounds in the mother, fetus, and infant. These models were derived from PBPK models for PFOA/PFOS that were previously developed for adult humans and rats during gestation and lactation and from existing human pregnancy and lactation models developed for other chemicals. The models simulated PFOA and PFOS concentrations in fetal, infant, and maternal plasma and milk, were compared to available data in humans, and also were used to estimate maternal exposure. The models reported here identified several research needs, which include (1) the identification of transporters involved in renal resorption to explain the multiyear half-lives of these compounds in humans, (2) factors affecting clearance of PFOA/PFOS during gestation and lactation, and (3) data to estimate clearance of PFOA/PFOS in infants. These models may help address concerns regarding possible adverse health effects due to PFOA/PFOS exposure in the fetus and infant and may be useful in comparing pharmacokinetics across life stages.

  9. Multidisciplinary perspectives on the history of human interactions with life in the ocean

    DEFF Research Database (Denmark)

    MacDiarmid, Alison; MacKenzie, Brian; Ojaveer, Henn


    There is an essentially circular interaction between the human social system and the marine ecosystem. The Oceans Past V Conference "Multidisciplinary perspectives on the history of human interactions with life in the ocean" held in Tallinn, Estonia, in May 2015 was an opportunity for the present......There is an essentially circular interaction between the human social system and the marine ecosystem. The Oceans Past V Conference "Multidisciplinary perspectives on the history of human interactions with life in the ocean" held in Tallinn, Estonia, in May 2015 was an opportunity...... volume of the ICES JMS and highlight issues which arose during general discussion. We make two conclusions. First, to have greater impact and ensure more efficient use of knowledge gained from marine historical ecology (MHE) and marine environmental history (MEH) in ecosystem-based management and related...... policy development, practitioners need to work more routinely with population and ecological modellers and statisticians. This will allow greater processing of the available historical data to derive ecologically meaningful properties that can then be used to assess the ecological impact of long...

  10. The Life Mission Theory VI. A Theory for the Human Character: Healing with Holistic Medicine Through Recovery of Character and Purpose of Life

    Directory of Open Access Journals (Sweden)

    Søren Ventegodt


    Full Text Available The human character can be understood as an extension of the life mission or purpose of life, and explained as the primary tool of a person to impact others and express the purpose of life. Repression of the human character makes it impossible for a person to realize his personal mission in life and, therefore, is one of the primary causes of self-repression resulting in poor quality of life, health, and ability. From Hippocrates to Hahnemann, repression of physical, mental, and spiritual character can be seen as the prime cause of disease, while recovery of character has been the primary intention of the treatment. In this paper, human character is explained as an intersubjective aspect of consciousness with the ability to influence the consciousness of another person directly. To understand consciousness, we reintroduce the seven-ray theory of consciousness explaining consciousness in accordance with a fractal ontology with a bifurcation number of seven (the numbers four to ten work almost as well. A case report on a female, aged 35 years, with severe hormonal disturbances, diagnosed with extremely early menopause, is presented and treated according to the theory of holistic existential healing (the holistic process theory of healing. After recovery of her character and purpose of life, her quality of life dramatically improved and hormonal status normalized. We believe that the recovery of human character and purpose of life was the central intention of Hippocrates and thus the original essence of western medicine. Interestingly, there are strong parallels to the peyote medicine of the Native Americans, the African Sangomas, the Australian Aboriginal healers, and the old Nordic medicine. The recovery of human character was also the intention of Hahnemann's homeopathy. We believe that we are at the core of consciousness-based medicine, as recovery of purpose of life and human character has been practiced as medicine in most human cultures

  11. A model to predict the beginning of the pollen season

    DEFF Research Database (Denmark)

    Toldam-Andersen, Torben Bo


    In order to predict the beginning of the pollen season, a model comprising the Utah phenoclirnatography Chill Unit (CU) and ASYMCUR-Growing Degree Hour (GDH) submodels were used to predict the first bloom in Alms, Ulttirrs and Berirln. The model relates environmental temperatures to rest completion...... and bud development. As phenologic parameter 14 years of pollen counts were used. The observed datcs for the beginning of the pollen seasons were defined from the pollen counts and compared with the model prediction. The CU and GDH submodels were used as: 1. A fixed day model, using only the GDH model...... for fruit trees are generally applicable, and give a reasonable description of the growth processes of other trees. This type of model can therefore be of value in predicting the start of the pollen season. The predicted dates were generally within 3-5 days of the observed. Finally the possibility of frost...

  12. Isolation of human anti-serum albumin Fab antibodies with an extended serum-half life. (United States)

    Kang, Hyeon-Ju; Kim, Hye-Jin; Cha, Sang-Hoon


    The serum albumin (SA) has been exploited to generate long-acting biotherapeutics by taking advantage of the FcRn-mediated recycling mechanism in a direct or an indirect way. Since Fab fragments have been proven to be clinically safe for human usage, we assumed that human anti-SA Fab antibodies could have a great potential as a carrier molecule to extend the serum half-life of therapeutic proteins. We, herein, had attempted to isolate anti-SA Fab antibodies from HuDVFab-8L antibody library via a phage display technology, and identified eight discrete human Fab antibodies. One of the Fab antibodies, SL335, showed the strongest binding reactivity to human SA with nM range of affinity at both pH 6 and pH 7.4, and cross-reacted to SAs from various species including rat, mouse, canine and monkey. The in vivo pharmacokinetic assay using a rat model indicated that SL335 has approximately 10 fold longer serum half-life and 26 to 44-fold increase in AUC0 → ∞ compared to the negative control Fab molecule in both intravenous and subcutaneous administrations. Knowing that Fabs have proven to be safe in clinics for a long time, SL335 seems to have a great potential in generating long-acting protein drugs by tagging effector molecules with either chemical conjugation or genetic fusion. Copyright © 2015 Elsevier B.V. All rights reserved.

  13. Tendencies in the development of Russian musical culture at the beginning of the XX century




    The article describes the main tendencies in the development of musical life and culture in Russia at the end of the XIX-beginning of the XX centuries. This period symbolized the establishing of new cultural trends and influences in musical culture that have not suited classical academic canons. New forms of musical activity found their practical realization in creation of people''s instrument orchestras and choirs and changing of students'' composition at the higher institutions of musical e...

  14. Early life history and habitat ecology of estuarine fishes: responses to natural and human induced change

    Directory of Open Access Journals (Sweden)

    Kenneth Able


    Full Text Available Our understanding of the early life history of fishes and their habitats has proceeded from basic natural history to ecology, but we often need to return to natural history to address deficiencies in conceptual and quantitative models of ecosystems. This understanding is further limited by the complex life history of fishes and the lack of appreciation of shifting baselines in estuaries. These inadequacies are especially evident when we try to address the effects of human influences, e.g. fishing, urbanization, and climate change. Often our baselines are inadequate or inaccurate. Our work has detected these along the coasts of the U.S. in extensive time series of larval fish ingress into estuaries, studies of the effects of urbanization, and responses to catastrophes such as the BP oil spill. Long-term monitoring, especially, continues to provide critical insights

  15. Legal guardians understand how children with the human immunodeficiency virus perceive quality of life and stigma. (United States)

    Rydström, Lise-Lott; Wiklander, Maria; Ygge, Britt-Marie; Navér, Lars; Eriksson, Lars E


    This aim of this study was to describe how legal guardians assessed health-related quality of life and HIV-related stigma in children with the human immunodeficiency virus (HIV) compared to the children's own ratings. A cross-sectional nationwide study was performed to compare how 37 children aged from eight to 16 years of age with perinatal HIV, and their legal guardians, assessed the children's health-related quality of life and HIV-related stigma. Data were collected using the 37-item DISABKIDS Chronic Generic Module and a short eight-item version of the HIV stigma scale. Intraclass correlations indicated concordance between the legal guardians' ratings and the children's own ratings of the child's health-related quality of life and HIV-related stigma. There were no statistically significant differences between the ratings of the two groups and gender did not have any impact on the results. Both groups indicated that the children had concerns about being open about their HIV status. The results of this study indicated that legal guardians understood how their children perceived their health-related quality of life and HIV-related stigma. The results also indicated the need for interventions to support both the children and legal guardians when it came to disclosing the child's HIV status. ©2015 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.

  16. Understanding beginning teacher induction: A contextualized examination of best practice


    Sean Kearney


    The problems that teachers face early in their careers are a major factor in growing rates of attrition among neophyte teachers. According to the Organisation for Economic Co-operation and Development, high rates of attrition, coupled with and aging teacher population in many countries in the developed world, may cause a teacher shortage crisis in coming years. Beginning teacher induction is an imperative process in acculturating teachers to their new careers and helping them overcome the har...

  17. Exploring Life Support Architectures for Evolution of Deep Space Human Exploration (United States)

    Anderson, Molly S.; Stambaugh, Imelda C.


    Life support system architectures for long duration space missions are often explored analytically in the human spaceflight community to find optimum solutions for mass, performance, and reliability. But in reality, many other constraints can guide the design when the life support system is examined within the context of an overall vehicle, as well as specific programmatic goals and needs. Between the end of the Constellation program and the development of the "Evolvable Mars Campaign", NASA explored a broad range of mission possibilities. Most of these missions will never be implemented but the lessons learned during these concept development phases may color and guide future analytical studies and eventual life support system architectures. This paper discusses several iterations of design studies from the life support system perspective to examine which requirements and assumptions, programmatic needs, or interfaces drive design. When doing early concept studies, many assumptions have to be made about technology and operations. Data can be pulled from a variety of sources depending on the study needs, including parametric models, historical data, new technologies, and even predictive analysis. In the end, assumptions must be made in the face of uncertainty. Some of these may introduce more risk as to whether the solution for the conceptual design study will still work when designs mature and data becomes available.

  18. Modulation of the DNA damage response during the life cycle of human papillomaviruses. (United States)

    Anacker, Daniel C; Moody, Cary A


    Human papillomavirus (HPV) is the most common sexually transmitted viral infection. Infection with certain types of HPV pose a major public health risk as these types are associated with multiple human cancers, including cervical cancer, other anogenital malignancies and an increasing number of head and neck cancers. The HPV life cycle is closely tied to host cell differentiation with late viral events such as structural gene expression and viral genome amplification taking place in the upper layers of the stratified epithelium. The DNA damage response (DDR) is an elaborate signaling network of proteins that regulate the fidelity of replication by detecting, signaling and repairing DNA lesions. ATM and ATR are two kinases that are major regulators of DNA damage detection and repair. A multitude of studies indicate that activation of the ATM (Ataxia telangiectasia mutated) and ATR (Ataxia telangiectasia and Rad3-related) pathways are critical for HPV to productively replicate. This review outlines how HPV interfaces with the ATM- and ATR-dependent DNA damage responses throughout the viral life cycle to create an environment supportive of viral replication and how activation of these pathways could impact genomic stability. Copyright © 2016 Elsevier B.V. All rights reserved.

  19. Home Is Where Art Begins: The Works of Clyde Connell (United States)

    Kuster, Deborah


    Students can be inspired as they examine the art and life of Clyde Connell (1901-1998). Connell was a woman who lived almost her whole life within a 50-mile radius of Shreveport, Louisiana, but traveled to New York City regularly for years. Connell was nearly 60 years old before she focused full attention on making art, and her most creative years…

  20. Leadership Begins at the End of Your Comfort Zone (United States)

    Ryder, Marilou


    The path one chooses in life may not always be an easy one. Through simple acts of failure and disappointment, the author learned a lot about her inspiration to become a leader and what it actually took to make them a reality. As a woman who had little confidence to handle major life changes, the author values every second of the experience.…

  1. Life history trade-offs explain the evolution of human pygmies. (United States)

    Migliano, Andrea Bamberg; Vinicius, Lucio; Lahr, Marta Mirazón


    Explanations for the evolution of human pygmies continue to be a matter of controversy, recently fuelled by the disagreements surrounding the interpretation of the fossil hominin Homo floresiensis. Traditional hypotheses assume that the small body size of human pygmies is an adaptation to special challenges, such as thermoregulation, locomotion in dense forests, or endurance against starvation. Here, we present an analysis of stature, growth, and individual fitness for a large population of Aeta and a smaller one of Batak from the Philippines and compare it with data on other pygmy groups accumulated by anthropologists for a century. The results challenge traditional explanations of human pygmy body size. We argue that human pygmy populations and adaptations evolved independently as the result of a life history tradeoff between the fertility benefits of larger body size against the costs of late growth cessation, under circumstances of significant young and adult mortality. Human pygmies do not appear to have evolved through positive selection for small stature-this was a by-product of selection for early onset of reproduction.

  2. The value of human life and the attitude towards abortion A christian and bioethic approach

    Directory of Open Access Journals (Sweden)

    ANDREI Gabriela


    Full Text Available Abortion, the cruel reality of the contemporary mankind, bites with no mercy our life and lacerates the humanity face, relativizing life’s ultimate value. We fight for the animal’s lives and rights, but we kill our children in womb. We are confused and living up to the rules imposed by us, and we fail, because we do not see the „Light of the world” (John 8,12 - Jesus Christ, losing sight of the reference frame – the divinity. We have declared God dead [1], the fountain of life , and we put ourselves in His place. We lost indiscriminatingly the values of “as Gods” ( Genesis 3,5 and “as God’s image” (Genesis 1, 27 drifting on the gradient of big fails, as big as God we have chased but never listened. So, that, from the survival outlook and lacking of love in our life, the fight for survival targets against the somebody ‘s else life, and no illustration is more eloquent and tragic as the mothers, families and society’s fight against the procreation generally, and particularly against the unborn child.


    Directory of Open Access Journals (Sweden)

    Aivaz M. KAMER AINUR


    Full Text Available Currently, two anthropological models are dominant in Romania. The first is the atheistic-evolutionary model and the second is the Christian model. The purpose of this article is to assess the students’ opinion on the two anthropological models and, in particular, on the purpose of human life. To that effect, there have been used the coefficients of association between the main aspects of the two models. Starting from the two outlined approaches, this paper aims to investigate the opinions of the students from two different specializations within Ovidius University of Constanta – the Faculty of Economics and the Faculty of Theology – on the issues mentioned above

  4. Cell surface proteome analysis of human-hosted Trypanosoma cruzi life stages

    DEFF Research Database (Denmark)

    Queiroz, Rayner M L; Charneau, Sébastien; Bastos, Izabela M D


    addressed the analysis of the plasma membrane (PM) subproteome from T. cruzi human-hosted life stages, trypomastigote and axenic amastigote, by two complementary PM protein enrichment techniques followed by identification using an LC-MS/MS approach. The results revealed an extensive repertoire of proteins...... in the PM subproteomes, including enzymes that might be suitable candidates for drug intervention. The comparison of the cell surface proteome among the life forms revealed some potentially stage-specific enzymes, although the majority was shared by both stages. Bioinformatic analysis showed that the vast......Chagas' disease is a neglected infectious illness, caused by the protozoan Trypanosoma cruzi. It remains a challenging health issue in Latin America, where it is endemic, and so far there is no immunoprophylatic vaccine or satisfactory chemotherapic treatment for its chronic stage. The present work...

  5. Begin at the beginning: A BAC-end view of the passion fruit (Passiflora) genome. (United States)

    Santos, Anselmo Azevedo; Penha, Helen Alves; Bellec, Arnaud; Munhoz, Carla de Freitas; Pedrosa-Harand, Andrea; Bergès, Hélène; Vieira, Maria Lucia Carneiro


    The passion fruit (Passiflora edulis) is a tropical crop of economic importance both for juice production and consumption as fresh fruit. The juice is also used in concentrate blends that are consumed worldwide. However, very little is known about the genome of the species. Therefore, improving our understanding of passion fruit genomics is essential and to some degree a pre-requisite if its genetic resources are to be used more efficiently. In this study, we have constructed a large-insert BAC library and provided the first view on the structure and content of the passion fruit genome, using BAC-end sequence (BES) data as a major resource. The library consisted of 82,944 clones and its levels of organellar DNA were very low. The library represents six haploid genome equivalents, and the average insert size was 108 kb. To check its utility for gene isolation, successful macroarray screening experiments were carried out with probes complementary to eight Passiflora gene sequences available in public databases. BACs harbouring those genes were used in fluorescent in situ hybridizations and unique signals were detected for four BACs in three chromosomes (n=9). Then, we explored 10,000 BES and we identified reads likely to contain repetitive mobile elements (19.6% of all BES), simple sequence repeats and putative proteins, and to estimate the GC content (~42%) of the reads. Around 9.6% of all BES were found to have high levels of similarity to plant genes and ontological terms were assigned to more than half of the sequences analysed (940). The vast majority of the top-hits made by our sequences were to Populus trichocarpa (24.8% of the total occurrences), Theobroma cacao (21.6%), Ricinus communis (14.3%), Vitis vinifera (6.5%) and Prunus persica (3.8%). We generated the first large-insert library for a member of Passifloraceae. This BAC library provides a new resource for genetic and genomic studies, as well as it represents a valuable tool for future whole genome

  6. Next Generation Life Support Project: Development of Advanced Technologies for Human Exploration Missions (United States)

    Barta, Daniel J.


    Next Generation Life Support (NGLS) is one of several technology development projects sponsored by the National Aeronautics and Space Administration s Game Changing Development Program. NGLS is developing life support technologies (including water recovery, and space suit life support technologies) needed for humans to live and work productively in space. NGLS has three project tasks: Variable Oxygen Regulator (VOR), Rapid Cycle Amine (RCA) swing bed, and Alternative Water Processing. The selected technologies within each of these areas are focused on increasing affordability, reliability, and vehicle self sufficiency while decreasing mass and enabling long duration exploration. The RCA and VOR tasks are directed at key technology needs for the Portable Life Support System (PLSS) for an Exploration Extravehicular Mobility Unit (EMU), with focus on prototyping and integrated testing. The focus of the Rapid Cycle Amine (RCA) swing-bed ventilation task is to provide integrated carbon dioxide removal and humidity control that can be regenerated in real time during an EVA. The Variable Oxygen Regulator technology will significantly increase the number of pressure settings available to the space suit. Current spacesuit pressure regulators are limited to only two settings while the adjustability of the advanced regulator will be nearly continuous. The Alternative Water Processor efforts will result in the development of a system capable of recycling wastewater from sources expected in future exploration missions, including hygiene and laundry water, based on natural biological processes and membrane-based post treatment. The technologies will support a capability-driven architecture for extending human presence beyond low Earth orbit to potential destinations such as the Moon, near Earth asteroids and Mars.

  7. A life among atoms, or how it was all beginning, here and elsewhere

    International Nuclear Information System (INIS)

    Simane, C.


    Personal recollections giving a plastic picture of the history of nuclear research and nuclear energy in Czechoslovakia during the post-war period till the 1960s, highlighting all the milestones of that pioneering era. (P.A.)

  8. Beginning and growth of defects under coatings during fatigue tests

    International Nuclear Information System (INIS)

    Flavenot, J.F.; Dumousseau, P.; Bernard, J.L.; Slama, G.; Doule, A.


    To estimate the defects of some tubes of PWR, tensile fatigue test have been repeated on materials having real defects at the interface of a 16 MND 5 steel and of its stainless steel coating. To simulate the real working conditions, these tests have been carried out at 300 0 C. The results obtained, allow to follow the complete defect evolution. The evolution of the shape and the growth of the defect in the 16 MND 5 steel and in the stainless steel are described. Prediction models concerning the beginning and the growth of such defects agree with the results obtained [fr

  9. Criterion of damage beginning: experimental identification for laminate composite

    International Nuclear Information System (INIS)

    Thiebaud, F.; Perreux, D.; Varchon, D.; Lebras, J.


    The aim of this study is to propose a criterion of damage beginning for laminate composite. The materials is a glass-epoxy laminate [+55 deg.,-55 deg.[ n performed by winding filament process. First of all a description of the damage is performed and allows to define a damage variable. Thanks to the potential of free energy, an associated variable is defined. The damage criterion is written by using this last one. The parameter of the criterion is identified using mechanical and acoustical methods. The result is compared and exhibit a good agreement. (authors). 13 refs., 5 figs

  10. A Conceptual Model for Teaching the Relationship of Daily Life and Human Environmental Impact to Ecological Function (United States)

    Wyner, Yael


    In the general activity of daily life, it is easy to miss our dependency on the Earth's ecology. At the same time that people are living apparently separate from the environment, our impact on the Earth is increasing. This study seeks to understand how teachers can bridge this persistent disconnect of daily life from ecology and human impact.…

  11. Biospheric Life Support - integrating biological regeneration into protection of humans in space. (United States)

    Rocha, Mauricio; Iha, Koshun


    retirement (2016). The extension will allow partner agencies to deploy new experiments there, resuming basic research focusing more forward-looking goals. For deep-space, since consumables logistics becomes more difficult- and habitability an issue, with diminishing Earth's view, further research has been recommended. Four major areas have been identified for human protection: (1) radiation mitigation; (2) highly recyclable bio-regenerative (BR) LSS; (3) micro-gravity countermeasures- including artificial gravity (AG), and (4) psychological safety. To contribute to the efforts to address these issues, a basic lab/virtual iterative research has been proposed, assuming (in a worst case scenario) that: I) It won't be possible to send people to long deep space missions, safely, with the current (low quality of life) support technology (ISS micro-gravity 'up-gradings'); II) The alternative to implant a Mars surface human supportive biosphere would also not be possible, due to environmental/ evolutionary restraints (life could adapt and survive, but not necessarily to favor humans). From the above considerations arises the question: Would an average approach be possible where, by applying the artificial gravity concept to S/Cs, a fragment of Earth bio-regenerative environment could be integrated inside reusable manned vehicles- thus enhancing its habitability/autonomy in long deep space missions? For this research question a provisory answer/hypothesis has been provided. And to test it, a small AG+BR bench simulator (plus computer methods) has been devised.

  12. Patterns of Early-Life Gut Microbial Colonization during Human Immune Development: An Ecological Perspective

    Directory of Open Access Journals (Sweden)

    Isabelle Laforest-Lapointe


    Full Text Available Alterations in gut microbial colonization during early life have been reported in infants that later developed asthma, allergies, type 1 diabetes, as well as in inflammatory bowel disease patients, previous to disease flares. Mechanistic studies in animal models have established that microbial alterations influence disease pathogenesis via changes in immune system maturation. Strong evidence points to the presence of a window of opportunity in early life, during which changes in gut microbial colonization can result in immune dysregulation that predisposes susceptible hosts to disease. Although the ecological patterns of microbial succession in the first year of life have been partly defined in specific human cohorts, the taxonomic and functional features, and diversity thresholds that characterize these microbial alterations are, for the most part, unknown. In this review, we summarize the most important links between the temporal mosaics of gut microbial colonization and the age-dependent immune functions that rely on them. We also highlight the importance of applying ecology theory to design studies that explore the interactions between this complex ecosystem and the host immune system. Focusing research efforts on understanding the importance of temporally structured patterns of diversity, keystone groups, and inter-kingdom microbial interactions for ecosystem functions has great potential to enable the development of biologically sound interventions aimed at maintaining and/or improving immune system development and preventing disease.

  13. Health-related quality of life in the CDC Anthrax Vaccine Adsorbed Human Clinical Trial. (United States)

    Stewart, Brock; Rose, Charles E; Tokars, Jerome I; Martin, Stacey W; Keitel, Wendy A; Keyserling, Harry L; Babcock, Janiine; Parker, Scott D; Jacobson, Robert M; Poland, Gregory A; McNeil, Michael M


    After the Department of Defense implemented a mandatory anthrax vaccination program in 1998 concerns were raised about potential long-term safety effects of the current anthrax vaccine. The CDC multicenter, randomized, double-blind, placebo-controlled Anthrax Vaccine Adsorbed (AVA) Human Clinical Trial to evaluate route change and dose reduction collected data on participants' quality of life. Our objective is to assess the association between receipt of AVA and changes in health-related quality of life, as measured by the SF-36 health survey (Medical Outcomes Trust, Boston, MA), over 42 months after vaccination. 1562 trial participants completed SF-36v2 health surveys at 0, 12, 18, 30 and 42 months. Physical and mental summary scores were obtained from the survey results. We used Generalized Estimating Equations (GEE) analyses to assess the association between physical and mental score difference from baseline and seven study groups receiving either AVA at each dose, saline placebo at each dose, or a reduced AVA schedule substituting saline placebo for some doses. Overall, mean physical and mental scores tended to decrease after baseline. However, we found no evidence that the score difference from baseline changed significantly differently between the seven study groups. These results do not favor an association between receipt of AVA and an altered health-related quality of life over a 42-month period. Published by Elsevier Ltd.



    Dr. K. Ramamurthi; Mr. Lambodar Saha


    Various strategic practices have already been established to promote the value of Human Resource Management in organizations. The Human Resource Management function is now considered as a strategic tool in the formulation and implementation of organizational strategies to attain its objectives. Automobile Industries are chosen as subjects for this study with specific aspects relating to various strategic human resource management practices and its impact on work-life balance and to determine ...

  15. Fluid Regulation for Life and Human Performance (United States)

    Byars, Allyn

    Fluid regulation for life and performance is examined in this chapter. First, however, the nature and function of water in human physiology as it pertains to maintaining fluid balance on a daily basis must be examined. The relation of water to human performance is also examined as the body's requirement for this fluid before, during, and after exercise is explored. In addition, other fluid sources, such as carbohydrate drinks, are examined for their efficacy, including specifically formulated beverages marketed for use during exercise. Finally, recommendations for application in the athletic environment are given.

  16. The Era of International Space Station Utilization Begins: Research Strategy, International Collaboration, and Realized Potential (United States)

    Thumm, Tracy; Robinson, Julie A.; Ruttley, Tara; Johnson-Green, Perry; Karabadzhak, George; Nakamura, Tai; Sorokin, Igor V.; Zell, Martin; Jean, Sabbagh


    With the assembly of the International Space Station (ISS) nearing completion and the support of a full-time crew of six, a new era of utilization for research is beginning. For more than 15 years, the ISS international partnership has weathered financial, technical and political challenges proving that nations can work together to complete assembly of the largest space vehicle in history. And while the ISS partners can be proud of having completed one of the most ambitious engineering projects ever conceived, the challenge of successfully using the platform remains. During the ISS assembly phase, the potential benefits of space-based research and development were demonstrated; including the advancement of scientific knowledge based on experiments conducted in space, development and testing of new technologies, and derivation of Earth applications from new understanding. The configurability and human-tended capabilities of the ISS provide a unique platform. The international utilization strategy is based on research ranging from physical sciences, biology, medicine, psychology, to Earth observation, human exploration preparation and technology demonstration. The ability to complete follow-on investigations in a period of months allows researchers to make rapid advances based on new knowledge gained from ISS activities. During the utilization phase, the ISS partners are working together to track the objectives, accomplishments, and the applications of the new knowledge gained. This presentation will summarize the consolidated international results of these tracking activities and approaches. Areas of current research on ISS with strong international cooperation will be highlighted including cardiovascular studies, cell and plant biology studies, radiation, physics of matter, and advanced alloys. Scientific knowledge and new technologies derived from research on the ISS will be realized through improving quality of life on Earth and future spaceflight endeavours

  17. IVF culture medium affects post-natal weight in humans during the first 2 years of life

    NARCIS (Netherlands)

    Kleijkers, S.H.; Montfoort, A.P. van; Smits, L.J.; Viechtbauer, W.; Roseboom, T.J.; Nelissen, E.C.; Coonen, E.; Derhaag, J.G.; Bastings, L.; Schreurs, I.E.; Evers, J.L.H.; Dumoulin, J.C.


    STUDY QUESTION: Is post-natal growth during the first 2 years of life in IVF singletons affected by type of medium used for culturing human embryos during an IVF treatment? SUMMARY ANSWER: The in vitro culture of human embryos in medium from Cook resulted in singletons with a lower weight during the

  18. [Richard Freiherr v. Krafft-Ebing and Sigmund Freud--discourse on the "normality" and "perversion" of human sexuality at the close of the 19th century and the beginning of the 20th century]. (United States)

    Kapfhammer, Hans-Peter


    Sexuality has been defined a central feature of personal identity since the epoch of enlightenment and has gradually become a decisive issue also in societal and political terms. A major transfer from religion and religious institutions to medicine and medical experts and later on to neuropsychiatrists has to be underlined in the primary position to assess "normal" and "deviant" manifestations of sexuality. Richard Freiherr von Krafft-Ebing and Sigmund Freund play an eminent role in this "discourse on sexuality" (M. Foucault) during the nineteenth and beginning twentieth century on the way to modern sexology. Within this overarching context Krafft-Ebing's and Freud's theoretical conceptualizations of sexuality and perversion will be sketched and basic clinical and societal implications there out will be discussed.

  19. "Dark Victory" (prognosis negative): The beginnings of neurology on screen. (United States)

    Wijdicks, Eelco F M


    In "Dark Victory," released in theaters in 1939, the diagnosis and management of a progressive brain tumor was a central part of the screenplay, and this film marked the beginnings of the depiction of neurologic disease in cinema. Bette Davis' cinematic portrayal of a young woman dying from a brain tumor is close to the reality of denial, bargaining, a hope for a cure, and final acceptance. "Dark Victory" includes part of a neurologic examination (funduscopy, testing of strength, testing of stereognosis, and tendon reflexes). The film also alludes to decisions on what to tell the patient (better say nothing) and shows an implausible clinical course (an abrupt peaceful ending). The film is unusual in depicting the presentation of a brain tumor, but the cinematic portrayal of the vicissitudes of living with a brain tumor is often close to reality. © 2016 American Academy of Neurology.

  20. The beginnings of piezoelectricity a study in mundane physics

    CERN Document Server

    Katzir, Shaul; Gavroglu, Kostas


    Involving electricity, elasticity, thermodynamics and crystallography, several scientific traditions and approaches and leading physicists, the history of piezoelectricity provides an advantageous perspective on late nineteenth century physics and its development. The beginnings of piezoelectricity, the first history of the subject, exhaustively examines how these diverse influences led to the discovery of the phenomenon in 1880, and how they shaped its subsequent research until the consolidation of an empirical and theoretical knowledge of the field circa 1895. It studies a particular subdiscipline representative of many similar "mundane" branches of physics that did not bear revolutionary consequences beyond their field. Although most research is of this kind, such branches have rarely been studied by historians of science. Shaul Katzir's historical account shows that this mundane science was an intriguing intellectual and practical enterprise, which involved, among other things, originality, surprises and ...

  1. Can observations look back to the beginning of inflation?

    Directory of Open Access Journals (Sweden)

    C. Wetterich


    Full Text Available The cosmic microwave background can measure the inflaton potential only if inflation lasts sufficiently long before the time of horizon crossing of observable fluctuations, such that non-linear effects in the time evolution of Green's functions lead to a loss of memory of initial conditions for the ultraviolet tail of the spectrum. Within a derivative expansion of the quantum effective action for an interacting scalar field we discuss the most general solution for the correlation function, including arbitrary pure and mixed quantum states. In this approximation no loss of memory occurs – cosmic microwave observations see the initial spectrum at the beginning of inflation, processed only mildly by the scale-violating effects at horizon crossing induced by the inflaton potential.

  2. Can observations look back to the beginning of inflation?

    International Nuclear Information System (INIS)

    Wetterich, C.


    The cosmic microwave background can measure the inflaton potential only if inflation lasts sufficiently long before the time of horizon crossing of observable fluctuations, such that non-linear effects in the time evolution of Green's functions lead to a loss of memory of initial conditions for the ultraviolet tail of the spectrum. Within a derivative expansion of the quantum effective action for an interacting scalar field we discuss the most general solution for the correlation function, including arbitrary pure and mixed quantum states. In this approximation no loss of memory occurs – cosmic microwave observations see the initial spectrum at the beginning of inflation, processed only mildly by the scale-violating effects at horizon crossing induced by the inflaton potential.

  3. Mining: The beginning and the end of the nuclear cycle

    International Nuclear Information System (INIS)

    Walls, J.


    Mining is one of the world's oldest industries, with a rich history that has evolved into modern times. A new chapter in that history is currently being written in southeastern New Mexico at the Waste Isolation Pilot Plant (WIPP). The beginning phase of the nuclear industry occurred when uranium was mined from the underground and processed to develop the first fuel source for the nuclear history. The WIPP may well be the final chapter in closing out the nuclear cycle, by the disposal of nuclear waste 2150 feet in the underground repository. At the WIPP, traditional procedures for underground mining activities have been significantly altered in order to ensure underground safety and project adherence to numerous regulatory requirements. Innovative techniques have been developed for the WIPP underground procedures, mining equipment, and operating environments. The mining emphasis is upon quality of the excavation, not, as in conventional mines, in the production of ore

  4. Beginning C

    CERN Document Server

    Horton, Ivor


    Beginning C, 5th Edition teaches you how to program using the widely-available C language. You'll begin from first-principles and progress through step-by-step examples to become a competent, C-language programmer. All you need are this book and any of the widely available free or commercial C or C++ compilers, and you'll soon be writing real C programs. C is a foundational language that every programmer ought to know. C is the basis for C# used in Microsoft .NET programming. It is the basis for Objective-C used in programming for the iPhone, the iPad, and other Apple devices. It is the basis


    Directory of Open Access Journals (Sweden)

    Laurizete Ferragut Passos


    Full Text Available The research assumes that the presence of a renewed faculty has been working in the Teaching Degree and Pedagogy courses, specific contexts of initial teacher training. These training teachers are starting a career in higher education and part of them carries significant experience as a teacher of basic education. Knowing what constitutes the professional development of this trainer, beginner in a segment, higher education, and experienced in another, basic education, and reflect on the perception of their performance and their role as trainers of future teachers constituted the research objectives. For this article we will analyze the interview data from a beginning teacher in the Bachelor's Degree. The text is provided by the studies by Marcelo Garcia (1999; Day (2001; Wedge (2005; Imbernon (2009, 2011; Vaillant and Marcelo (2012; among others. The results show that the teacher realizes the process of their professional development to be always in progress, non-linear, crossed by different factors, with a permanent feeling of incompleteness; recalls the importance of the work period in basic education schools for their professional development and performance as a teacher trainer.

  6. Alterations of the cytoskeleton in human cells in space proved by life-cell imaging (United States)

    Corydon, Thomas J.; Kopp, Sascha; Wehland, Markus; Braun, Markus; Schütte, Andreas; Mayer, Tobias; Hülsing, Thomas; Oltmann, Hergen; Schmitz, Burkhard; Hemmersbach, Ruth; Grimm, Daniela


    Microgravity induces changes in the cytoskeleton. This might have an impact on cells and organs of humans in space. Unfortunately, studies of cytoskeletal changes in microgravity reported so far are obligatorily based on the analysis of fixed cells exposed to microgravity during a parabolic flight campaign (PFC). This study focuses on the development of a compact fluorescence microscope (FLUMIAS) for fast live-cell imaging under real microgravity. It demonstrates the application of the instrument for on-board analysis of cytoskeletal changes in FTC-133 cancer cells expressing the Lifeact-GFP marker protein for the visualization of F-actin during the 24th DLR PFC and TEXUS 52 rocket mission. Although vibration is an inevitable part of parabolic flight maneuvers, we successfully for the first time report life-cell cytoskeleton imaging during microgravity, and gene expression analysis after the 31st parabola showing a clear up-regulation of cytoskeletal genes. Notably, during the rocket flight the FLUMIAS microscope reveals significant alterations of the cytoskeleton related to microgravity. Our findings clearly demonstrate the applicability of the FLUMIAS microscope for life-cell imaging during microgravity, rendering it an important technological advance in live-cell imaging when dissecting protein localization. PMID:26818711

  7. Alterations of the cytoskeleton in human cells in space proved by life-cell imaging. (United States)

    Corydon, Thomas J; Kopp, Sascha; Wehland, Markus; Braun, Markus; Schütte, Andreas; Mayer, Tobias; Hülsing, Thomas; Oltmann, Hergen; Schmitz, Burkhard; Hemmersbach, Ruth; Grimm, Daniela


    Microgravity induces changes in the cytoskeleton. This might have an impact on cells and organs of humans in space. Unfortunately, studies of cytoskeletal changes in microgravity reported so far are obligatorily based on the analysis of fixed cells exposed to microgravity during a parabolic flight campaign (PFC). This study focuses on the development of a compact fluorescence microscope (FLUMIAS) for fast live-cell imaging under real microgravity. It demonstrates the application of the instrument for on-board analysis of cytoskeletal changes in FTC-133 cancer cells expressing the Lifeact-GFP marker protein for the visualization of F-actin during the 24(th) DLR PFC and TEXUS 52 rocket mission. Although vibration is an inevitable part of parabolic flight maneuvers, we successfully for the first time report life-cell cytoskeleton imaging during microgravity, and gene expression analysis after the 31(st) parabola showing a clear up-regulation of cytoskeletal genes. Notably, during the rocket flight the FLUMIAS microscope reveals significant alterations of the cytoskeleton related to microgravity. Our findings clearly demonstrate the applicability of the FLUMIAS microscope for life-cell imaging during microgravity, rendering it an important technological advance in live-cell imaging when dissecting protein localization.

  8. 3 CFR 8339 - Proclamation 8339 of January 15, 2009. National Sanctity of Human Life Day, 2009 (United States)


    ... has been committed to building a culture of life by vigorously promoting adoption and parental... building a culture of life in America. Also, I was proud to sign the Unborn Victims of Violence Act of 2004... citizens, we will prevail. NOW, THEREFORE, I, GEORGE W. BUSH, President of the United States of America, by...

  9. Some methods of human liquid and solid wastes utilization in bioregenerative life support systems (United States)

    Tikhomirova, N. A.; Ushakova, S. Á.; Tikhomirov, A. Á.; Zolotukhin, I. G.; Gribovskaya, I. V.; Gros, J. B.

    The possibility of stepwise utilization of human liquid and solid wastes with the purpose of an increase of a closure degree of bioregenerative life support systems BLSS and sodium chloride inclusion in the organic matter turnover was investigated On the first stage urine and faeces were subjected to oxidation by Yu A Kudenko physicochemical method On the next stage the products of human liquid and solid wastes oxidation were used for roots nutrition of wheat grown by substrate culture method Soil-like substrate the technology of which was described earlier was used as a substrate After the wheat cultivation the irrigational solution and the solution obtained in the result of substrate washing containing mineral elements not absorbed by the plants were used for cultivation of salt-tolerant Salicornia europaea plants The above-ground biomass of these vegetables can be used as a food and roots washed from dissoluble mineral elements can be added to the soil-like substrate Four consecutive wheat and Salicornia europaea vegetations were cultivated In the result of this complex technology of wheat and Salicornia europaea cultivation the soil-like substrate salinization by NaCl introduced into the irrigational solution together with the products of urine oxidation has considerably decreased

  10. Shelf-life evaluation of bilayered human skin equivalent, MyDerm™.

    Directory of Open Access Journals (Sweden)

    Wan Tai Seet

    Full Text Available Skin plays an important role in defense against infection and other harmful biological agents. Due to its fragile structure, skin can be easily damaged by heat, chemicals, traumatic injuries and diseases. An autologous bilayered human skin equivalent, MyDerm™, was engineered to provide a living skin substitute to treat critical skin loss. However, one of the disadvantages of living skin substitute is its short shelf-life, hence limiting its distribution worldwide. The aim of this study was to evaluate the shelf-life of MyDerm™ through assessment of cell morphology, cell viability, population doubling time and functional gene expression levels before transplantation. Skin samples were digested with 0.6% Collagenase Type I followed by epithelial cells dissociation with TrypLE Select. Dermal fibroblasts and keratinocytes were culture-expanded to obtain sufficient cells for MyDerm™ construction. MyDerm™ was constructed with plasma-fibrin as temporary biomaterial and evaluated at 0, 24, 48 and 72 hours after storage at 4°C for its shelf-life determination. The morphology of skin cells derived from MyDerm™ remained unchanged across storage times. Cells harvested from MyDerm™ after storage appeared in good viability (90.5%±2.7% to 94.9%±1.6% and had short population doubling time (58.4±8.7 to 76.9±19 hours. The modest drop in cell viability and increased in population doubling time at longer storage duration did not demonstrate a significant difference. Gene expression for CK10, CK14 and COL III were also comparable between different storage times. In conclusion, MyDerm™ can be stored in basal medium at 4°C for at least 72 hours before transplantation without compromising its functionality.

  11. Clinical Holistic Medicine: Induction of Spontaneous Remission of Cancer by Recovery of the Human Character and the Purpose of Life (the Life Mission

    Directory of Open Access Journals (Sweden)

    Søren Ventegodt


    Full Text Available The recovery of the human character and purpose of life with consciousness-based medicine seems to be able to induce spontaneous remissions in several diseases. On two different occasions, we observed breast tumors reduced to less than half their original diameters (clinically judged during a holistic session, when working with the patients in accordance with the holistic process theory of healing, the life mission theory, and the theory of human character. One tumor was histologically diagnosed as malign breast cancer prior to the session, while the other was under examination. As both patients had the affected regions of the breast surgically removed immediately after the session, we are unable to determine if they were actually healed by the holistic treatment. We find it extremely interesting that the size of a tumor can be reduced dramatically within a few hours of holistic treatment, when the patient is highly motivated for personal development. The reduction of tumor size is in accordance with the holistic view that many types of cancer are caused by emotional and existential disturbances. From a holistic perspective, cancer can be understood as a simple disturbance of the cells, arising from the tissue holding on to a trauma with strong emotional content. This is called “a blockage”, where the function of the cells is changed from their original function in the tissue to a function of holding emotions. The reduction of the tumor in the two cases happened when old painful emotions were identified in the tissues, in and around the tumor, and processed into understanding; when the patients finally did let go of negative beliefs and attitudes that had kept the feeling(s repressed to that part of the body, the tumor first softened and then disappeared, presumably by apoptosis. We believe that the consciousness-based/holistic medical toolbox has a serious additional offer to cancer patients, and we will therefore strongly encourage the

  12. The history of the beginning of the Russian cosmodrome Plesetsk (United States)

    Shatalov, D. V.


    There are three main dates in the history of the beginning and foundation of cosmodrome Plesetsk, each of which more or less may be considered as the birthday of cosmodrome. On January 11, 1957 the Soviet Government passed the resolution about the foundation of special military object with secret name "Angara", which later became known as cosmodrome Plesetsk, this secret object had to be situated in Plesetsk region Arhangelsk territory. It was named after the railway station Plesetsk and the town Plesetsk. The first Soviet Combat formation of intercontinental ballistic missiles R-7 of General designer Koroljev had to be located in that place, in thick northern taiga to the south of Arhangelsk. July 15, 1957 was the official birthday of the proving ground. That day colonel Gregorjev assumed his post as the missile unit commander. That was the time of the "cold war" between two superstates. Almost nobody thought about space employment of Plesetsk. First of all it was founded as the missile base for combat patrol of intercontinental ballistic missiles. And by July 15, 1961 four missile complexes for ballistic missile R-7 were on combat patrol. March 17, 1966 was the space birthday of Plesetsk. That day was the first missile launching of the rocket booster Vostok with space vehicle Cosmos 112. Since that time the rocket base Angara has become cosmodrome Plesetsk. It is interesting to know that till that time the USA secret service knew practically nothing about Plesetsk proving ground. The confirmation was the fact that there were two peaks of reconnaissance satellite launching intensity: during the Caribbean crisis in 1962 and after the launching of Cosmos 112 in 1966. In a year after the first space launching the proving ground near Plesetsk has become the main place in the USSR to launch the automatic vehicles.

  13. Semiotics of making: beginnings of a theoretical frame

    Directory of Open Access Journals (Sweden)

    Christopher Monson


    Full Text Available The contemporary problem of semiotics in architecture is an inherited struggle, not a chosen one. We consider the question of architectural communication because we inevitably recognize its centrality to the problem ofarchitecture itself. While the twentieth-century impact of Saussure and his birthing of structuralism gave architecture a new ground from which to reconceive its own semiotic functions, it was probably never possible that such a synchronic and undialogic theory would suit such a disparate and intersubjective activity. This is not to say that semiotics offers no guidance for the problem of architecture. It may say, however, that to use semiotics productively is not to start from its constructs but instead from architecture’s own.To that end, this study intends to establish a conceptualbasis for communication and meaning in architectural form by an inquiry into making. The initial judgment about why making might prove to be more useful than otherarchitectural characteristics is due to is its essential dialogicnature; it already is a semiotic. In that sense what follows is an opportunistic examination. It arises from what should be considered a powerful—if somewhat neglected—text on making: Elaine Scarry’s 1985 The Body in Pain. A deeper consideration of this work is long overdue. While Scarry’sbook seems to enjoy a rather wide readership, its potential impact has been largely unrealized since few scholars have developed its implications. Given the extraordinary originality of its argument, the artful construction of its prose, and the complex sophistication of its logic, it offers a rich—albeit demanding—place from which to begin.The objective of this study is to schematize Scarry’s theory of making such that connections to a semiotic understanding of its potentials may be realized. Following this effort, a short examination of one particular semiotic aspect of making will be argued as a tentative ground from which to

  14. Uses of the cost of human life in protection against ionizing radiations

    International Nuclear Information System (INIS)

    Hubert, Ph.; Dupuis-Ligieza, E.


    Management of radiation protection is based on the assumption that there is no safe level of exposure. Rathier, the risk (e.g. probability of induction of fatal cancers) is assumed to decrease in a linear way with the dose (measured by the effective dose in Sievert: Sv). Therefore, regulations state that all doses must be kept As Low As Reasonably Achievable (ALARA). Cost Benefit Analysis (CBA) ranges among the methods that allow identification of an 'optimum' protection level, balancing the risk reduction against the costs. That can be derived from exposure, expressed as a 'collective dose', with the help of the dose exposure relationship (100 Person-Sievert leads to 5 lethal cancers plus 2.2' equivalent lethal cancers 'due to non fatal cancers and heredity effect). Thus the 'Value of the Collective Dose', the usual parameter in decision making, is assigned a monetary value, and it is linked to the 'Value of Human Life'. Nevertheless, Cost Benefit Analysis is not the only possible method and pricing the Person-Sievert is therefore not necessary. Traditional pragmatic approaches and engineering judgement can be used. At present there is a development within Europe of CBA in radiation protection and 'Value of Person-Sievert' is put forward. A study was conducted in order better to understand what figures are cited, in which conditions those figures are really used, and what perspectives may be offered. (authors)

  15. Ars Longa, Vita Brevis. The Importance Of Art In Human Life. A Proustian Interpretation Of Honigmann’s Forever

    NARCIS (Netherlands)

    van Noortwijk, A.


    This article aims to present an exploration of the theme of art’s power within human life in Heddy Honigmann’s documentary film Forever (2006), which exemplifies her obsession with this topic. The film’s contemplation of art is a self-reflexive one, as it uses the medium of film to explore

  16. Beginning topology

    CERN Document Server

    Goodman, Sue E


    Beginning Topology is designed to give undergraduate students a broad notion of the scope of topology in areas of point-set, geometric, combinatorial, differential, and algebraic topology, including an introduction to knot theory. A primary goal is to expose students to some recent research and to get them actively involved in learning. Exercises and open-ended projects are placed throughout the text, making it adaptable to seminar-style classes. The book starts with a chapter introducing the basic concepts of point-set topology, with examples chosen to captivate students' imaginations while i

  17. Aeons the search for the beginning of time

    CERN Document Server

    Gorst, Martin


    The story of man's attempt to discover the moment that time began, from James Ussher's confident assertion in 1650 that the world was 5654 years old to the Hubble Space telescope's images of a world 13 billion years old, with a starry cast of eccentrics, mystics, scientists and visonaries. The moment of the beginning of time is one of science's Holy Grails, pursued by devotees and obsessives across the ages. Few were more committed than Bishop James Ussher who lost his sight in his 50-year quest, laboriously outlined in his 2000 Latin pages of Annals - a chronology of all known history - that is now famous only for one spectacularly inaccurate date: 4004BC, the creation of the world. Theology failed Ussher, just as it thwarted Theophilus of Antioch and many others before him. Geology was next to fail the test of time: the Comte de Buffon, working out the rate at which the Earth was supposed to have cooled, came up with age of 74,832 years, even though he suspected this was far too little. Biology had a go in ...

  18. Life-long endurance exercise in humans

    DEFF Research Database (Denmark)

    Mikkelsen, U R; Couppé, C; Karlsen, A


    Human aging is associated with a loss of skeletal muscle and an increase in circulating inflammatory markers. It is unknown whether endurance training (Tr) can prevent these changes. Therefore we studied 15 old trained (O-Tr) healthy males and, for comparison, 12 old untrained (O-Un), 10 Young.......05). Most importantly, life-long endurance exercise was associated with a lower level of the inflammatory markers CRP and IL-6 (p... physical endurance activity may play a role in reducing some markers of systemic inflammation, even within the normal range, and in maintaining muscle mass with aging....

  19. Beginning F#

    CERN Document Server

    Pickering, Robert


    Functional programming is perhaps the next big wave in application development. As experienced developers know, functional programming makes its mark by allowing application builders to develop solutions to complicated programming situations cleanly and efficiently. A rich history of functional languages, including Erlang and OCaml, leads the way to F#, Microsoft's effort to bring the elegance and focus of functional programming into the world of managed code and .NET. With Beginning F#, you have a companion that that will help you explore F# and functional programming in a .NET environment. T

  20. Beginning Spring

    CERN Document Server

    Caliskan, Mert


    Get up to speed quickly with this comprehensive guide toSpring Beginning Spring is the complete beginner's guide toJava's most popular framework. Written with an eye towardreal-world enterprises, the book covers all aspects of applicationdevelopment within the Spring Framework. Extensive samples withineach chapter allow developers to get up to speed quickly byproviding concrete references for experimentation, building askillset that drives successful application development byexploiting the full capabilities of Java's latest advances. Spring provides the exact toolset required to build anent

  1. Beginning Perl

    CERN Document Server

    Poe, Curtis 'Ovid'


    Everything beginners need to start programming with Perl Perl is the ever-popular, flexible, open source programming language that has been called the programmers’ Swiss army knife. This book introduces Perl to both new programmers and experienced ones who are looking to learn a new language. In the tradition of the popular Wrox Beginning guides, it presents step-by-step guidance in getting started, a host of try-it-out exercises, real-world examples, and everything necessary for a Perl novice to start programming with confidence. Introduces Perl to both new programmers and experienced o

  2. Beginning Hibernate

    CERN Document Server

    Minter, Dave; Ottinger, Joseph


    Beginning Hibernate, Third Edition is ideal if you're experienced in Java with databases (the traditional, or "connected," approach), but new to open-source, lightweight Hibernate, a leading object-relational mapping and database-oriented application development framework.This book packs in information about the release of the Hibernate 4.x persistence layer and provides a clear introduction to the current standard for object-relational persistence in Java. And since the book keeps its focus on Hibernate without wasting time on nonessential third-party tools, you'll be able to immediately star

  3. Beginning Hibernate

    CERN Document Server

    Linwood, Jeff


    Beginning Hibernate, Second Edition is ideal if you're experienced in Java with databases (the traditional, or "connected," approach), but new to open source, lightweight Hibernate-the de facto object-relational mapping and database-oriented application development framework. This book packs in brand-new information about the latest release of the Hibernate 3.5 persistence layer and provides a clear introduction to the current standard for object-relational persistence in Java. And since the book keeps its focus on Hibernate without wasting time on nonessential third-party tools, you

  4. The light of life: evidence that the sun modulates human lifespan. (United States)

    Lowell, Walter E; Davis, George E


    This paper describes the effects of radiation, probably ultraviolet radiation (UVR), on the human genome at peaks of solar cycles. This phenomenon was not previously reported because peak cycle lifespan had not been separated from non-peak lifespan. This paper reinforces the findings of others regarding the seasonality of various diseases and that there are factors occurring early in utero that increase susceptibility to diseases later in life. The authors use the vital statistics of 320,247 Maine citizens over a 29-year period to show that those born in 3-year peaks of 11-year solar cycles live an average of 1.5 years (CL 1.3-1.7) less than those born in non-peak years. Males are more sensitive than females to this phenomenon, which is statistically demonstrable well into adult life, showing the effect of probable UVR on the early human embryo despite superimposed adult lifetime hazards. The authors also show that changes in seasonal light modulate lifespan differently in males and females and that genome and environment must be tightly interactive early after conception. Published literature supports the hypothesis that UVR suppresses the maternal immune system by producing cytokines in circulating lymphocytes that probably affect the fetal genome. The intermittent and incompletely predictable solar cycles periodically stress the genomes of all life producing genetic changes which may be harmful or adaptive. The evidence presented in this study indicates that solar cycles, particularly the most irradiant which have occurred over the past 65 years, are fundamental engines of evolution, even underlying natural selection, and we bear their marks even to the end of our lives. Future researchers must further define the pathogenesis of solar radiation on early embryonic development to possibly minimize a predisposition to diseases at their origin. This study explores the relationship of season of birth and human lifespan particularly in reference to the intensity of

  5. Radiocarbon dating of the human eye lens crystallines reveal proteins without carbon turnover throughout life.

    Directory of Open Access Journals (Sweden)

    Niels Lynnerup

    Full Text Available BACKGROUND: Lens crystallines are special proteins in the eye lens. Because the epithelial basement membrane (lens capsule completely encloses the lens, desquamation of aging cells is impossible, and due to the complete absence of blood vessels or transport of metabolites in this area, there is no subsequent remodelling of these fibers, nor removal of degraded lens fibers. Human tissue ultimately derives its (14C content from the atmospheric carbon dioxide. The (14C content of the lens proteins thus reflects the atmospheric content of (14C when the lens crystallines were formed. Precise radiocarbon dating is made possible by comparing the (14C content of the lens crystallines to the so-called bomb pulse, i.e. a plot of the atmospheric (14C content since the Second World War, when there was a significant increase due to nuclear-bomb testing. Since the change in concentration is significant even on a yearly basis this allows very accurate dating. METHODOLOGY/PRINCIPAL FINDINGS: Our results allow us to conclude that the crystalline formation in the lens nucleus almost entirely takes place around the time of birth, with a very small, and decreasing, continuous formation throughout life. The close relationship may be further expressed as a mathematical model, which takes into account the timing of the crystalline formation. CONCLUSIONS/SIGNIFICANCE: Such a life-long permanence of human tissue has hitherto only been described for dental enamel. In confront to dental enamel it must be held in mind that the eye lens is a soft structure, subjected to almost continuous deformation, due to lens accommodation, yet its most important constituent, the lens crystalline, is never subject to turnover or remodelling once formed. The determination of the (14C content of various tissues may be used to assess turnover rates and degree of substitution (for example for brain cell DNA. Potential targets may be nervous tissues in terms of senile or pre

  6. Effects of low dose rate irradiation on life span prolongation of human premature-aging syndrome model mice

    International Nuclear Information System (INIS)

    Nomura, Takaharu


    We previously showed that Type II diabetes model mice prolonged of their life span by life long low dose rate irradiation. We also found that antioxidant function in variety tissues of some strain of mice were enhancement after low dose/low dose rate irradiation. The prolongation of life span might depend on certain damaged level of reactive oxygen species. We thought the effect of the prolongation was due to the enhancement of the antioxidant activities after irradiation. We investigated whether the enhancement of antioxidant activities after low dose rate irradiation had an effect on life span prolongation. Four-week-old female human premature-aging syndrome model mice, kl/kl (klotho) mice, which the life span of this model mouse is about 65 days, were irradiated with gamma rays at 0.35, 0.70 or 1.2 mGy/hr. The 0.70 mGy/hr-irradiated group remarkably effected on the prolongation of their life span. Some mice of the group were extremely survived for about and more 100 days. Antioxidant activities in the irradiated groups were enhancement by low dose rate irradiation, however the dependence of the dose rates were not clearly difference. These results suggest that the antioxidant activities in this model mouse were enhanced by the low dose rate irradiation, and may make it possible to prolong the life span of this mouse. (author)

  7. Playing Sport In The Stormy Sea Of Street Life | Human | African ...

    African Journals Online (AJOL)

    Currently, there are many street children in South Africa (SA). They have been robbed from the safe harbour of family life and on a daily basis experience the stormy sea of street life. Society has an obligation to intervene in the lives of these street children through, for example, quality education, basic health services and ...

  8. Immunity related to allergic response at the beginning of life


    Correa, Joaquina M.M.; Zuliani, Antonio


    OBJETIVO: considerando-se que é na infância que as manifestações alérgicas mais comuns (asma, rinite, dermatite, alergia alimentar) ocorrem, porque é no início da vida que o sistema imune pode ser induzido à sensibilização ao invés de tolerância alergênica, analisamos as principais peculiaridades imunológicas do feto e da criança jovem, inerentes à sensibilização e resposta alérgica. MÉTODOS: os autores realizaram revisão literária detalhada concernente à resposta imune inespecífica (barreira...

  9. Basile J. Luyet and the beginnings of transfusion cryobiology. (United States)

    Schmidt, Paul J


    The first president of the Society for Cryobiology was a Roman Catholic priest born in a mountain village in Switzerland. Basile J. Luyet immigrated to the United States in 1929 with doctorates in biology and in physics and then devoted his life to studies described best by the title of his early monograph "Life and Death at Low Temperatures." Established in the faculty at St. Louis University, he pursued studies on living matter in the cold that in midcareer led to efforts to vitrify red cells by ultrarapid cooling. As a purist who wanted to vitrify living matter without the assistance of cryoprotectant additives, he did not succeed with red cells. However, his 40 years of exploration of the biology of the cold joined physical chemistry with biology and made cryobiology into a new branch of scientific thought. A very formal man, he served both his God and his science with the dictum that "truth does not contradict truth." His contributions are preserved in the knowledge and wisdom that he created and in the memory of the people of the Alpine village of his birth.

  10. Brain-based origins of change language: a beginning. (United States)

    Feldstein Ewing, Sarah W; Yezhuvath, Uma; Houck, Jon M; Filbey, Francesca M


    Motivational interviewing (MI) is a promising treatment for heavy drinking. Client change talk (CT), a critical component of MI, has been associated with differential brain activation. The goal of this study was to begin to deconstruct how and why CT may affect the brain. Specifically, we sought to determine whether simply repeating statements in favor of change would cause differential brain activation, or whether client statements must be spontaneously generated within a therapeutic milieu in order to influence brain activation. We therefore examined blood oxygenation level dependent (BOLD) response following two types of client language (CT; and sustain talk, ST) across two conditions: (1) Self-Generated: CT and ST were elicited during an MI session vs. (2) Experimenter-Selected: a pre-established list of CT and ST was provided to the individual in the absence of an MI session. Across both conditions, participants' CT and ST were visually and aurally presented during fMRI. We enrolled 39 recent binge drinkers (41% male; M age=19.9; n=18 in Self-Generated group; n=21 in Experimenter-Selected group). We found that both types of client language (CT and ST) elicited greater BOLD activation in the Self-Generated vs. the Experimenter-Selected group in the left inferior frontal gyrus/anterior insula and superior temporal gyri (p≤0.001). These findings indicate that the nature of client language matters. It appears that it is not just the words themselves, but the origin (naturally generated within a therapeutic session) that influences brain-based effects. Copyright © 2014 Elsevier Ltd. All rights reserved.

  11. The deeper life bible church and the issues of human rights ...

    African Journals Online (AJOL)

    Such rights include; right to life, right to educate and be educated, right to own property, right to marry and be married, etcetera. These rights are guaranteed by the United Nations Organization (UNO) and constitutions of various countries of the world. These rights, as being practiced in the Deeper Life Bible Church, are the ...

  12. Virtual classroom design for Blended Learning: Human Development and Quality of Life

    Directory of Open Access Journals (Sweden)

    Juan Carlos Morales Intriago


    Full Text Available The explosive development in all areas of knowledge has evolved the scenarios of generation and transfer of knowledge, in terms of media, channels and supports, parallel to this appear new resources that optimize the processes of vocational training, whether formal, non-formal and informal. The EVA or Virtual Learning Environments evolve the traditional way of teaching a Blended environment, which is, combining classroom education with online training processes. The present work designs a training process set in Blended Learning for the subject Human Development and Quality of Life, summarizing in 8 steps the construction of the virtual and face-to-face environment, where starting from the common to the specific, the system is described systemically. The methodology applied in the present work was of Bibliographic and documentary type. To achieve the proposed objective, a systemic design was designed that divided the research into two stages: the exploration stage and the design stage. In the exploration stage, a large bibliographical collection was revised and in the design stage the virtual classroom model of the subject was constructed. Product of the investigation is a guide that guides step by step in the construction of virtual environments set in the Blended Learning.

  13. Sustainable Wearables: Wearable Technology for Enhancing the Quality of Human Life

    Directory of Open Access Journals (Sweden)

    Jaewoon Lee


    Full Text Available This paper aims to elicit insights about sustainable wearables by investigating recent advancements in wearable technology and their applications. Wearable technology has advanced considerably from a technical perspective, but it has stagnated due to barriers without penetrating wider society despite early positive expectations. This situation is the motivation behind the focus on studies by many research groups in recent years into wearable applications that can provide the best value from a human-oriented perspective. The expectation is that a new means to resolve the issue can be found from a viewpoint of sustainability; this is the main point of this paper. This paper first focuses on the trend of wearable technology like bodily status monitoring, multi-wearable device control, and smart networking between wearable sensors. Second, the development intention of such technology is investigated. Finally, this paper discusses about the applications of current wearable technology from the sustainable perspective, rather than detailed description of the component technologies employed in wearables. In this paper, the definition of sustainable wearables is discussed in the context of improving the quality of individual life, social impact, and social public interest; those wearable applications include the areas of wellness, healthcare, assistance for the visually impaired, disaster relief, and public safety. In the future, wearables will not be simple data trackers or fun accessories but will gain extended objectives and meanings that play a valuable role for individuals and societies. Successful and sustainable wearables will lead to positive changes for both individuals and societies overall.

  14. Human and ecological life cycle tools for the integrated assessment of systems (HELIAS)

    NARCIS (Netherlands)

    Guinée, Jeroen B.; Heijungs, Reinout; Kleijn, René; Van Der Voet, Ester; De Koning, Arjan; Van Oers, Lauran; Elshkaki, Ayman; Huele, Ruben; Huppes, Gjalt; Suh, Sangwon; Sleeswijk, Anneke Wegener

    Goal, Scope and Background. CML has contributed to the development of life cycle decision support tools, particularly Substance/Material Flow Analysis (SFA respectively MFA) and Life Cycle Assessment (LCA). Ever since these tools emerged there have been discussions on how these tools relate to each

  15. Extending the half-life of a fab fragment through generation of a humanized anti-human serum albumin Fv domain: An investigation into the correlation between affinity and serum half-life. (United States)

    Adams, Ralph; Griffin, Laura; Compson, Joanne E; Jairaj, Mark; Baker, Terry; Ceska, Tom; West, Shauna; Zaccheo, Oliver; Davé, Emma; Lawson, Alastair Dg; Humphreys, David P; Heywood, Sam


    We generated an anti-albumin antibody, CA645, to link its Fv domain to an antigen-binding fragment (Fab), thereby extending the serum half-life of the Fab. CA645 was demonstrated to bind human, cynomolgus, and mouse serum albumin with similar affinity (1-7 nM), and to bind human serum albumin (HSA) when it is in complex with common known ligands. Importantly for half-life extension, CA645 binds HSA with similar affinity within the physiologically relevant range of pH 5.0 - pH 7.4, and does not have a deleterious effect on the binding of HSA to neonatal Fc receptor (FcRn). A crystal structure of humanized CA645 Fab in complex with HSA was solved and showed that CA645 Fab binds to domain II of HSA. Superimposition with the crystal structure of FcRn bound to HSA confirmed that CA645 does not block HSA binding to FcRn. In mice, the serum half-life of humanized CA645 Fab is 84.2 h. This is a significant extension in comparison with albumin and serum half-life. Reduction in the affinity for MSA by 144-fold from 2.2 nM to 316 nM had no effect on serum half-life. Strikingly, despite a reduction in affinity to 62 µM, an extension in serum half-life of 26.4 h was still obtained. CA645 Fab and the CA645 Fab-HSA complex have been deposited in the Protein Data Bank (PDB) with accession codes, 5FUZ and 5FUO, respectively.

  16. The Fundamental Principle of Human Dignity and the Right to Life : Collision Any of These Fundamental Principles The Perspective of Abortion

    Directory of Open Access Journals (Sweden)

    Érika do Amaral Véras


    Full Text Available This legal article works the theme of the collision of the fundamental principles, especially the principle of human dignity and the right to life, abortion perspective. First, we discuss of fundamental rights, bringing its definition, observed the distinction between human rights and fundamental rights. Then the super principle of human dignity is covered and, soon after, the right to life is highlighted through its relevant elements. Finally, talks on a possible collision beween the fundamental right to life and the principle of human dignity, with a special focus on the issue of abortion.

  17. Models for the beginning of sour cherry blossom (United States)

    Matzneller, Philipp; Blümel, Klaus; Chmielewski, Frank-M.


    Seven different model approaches to calculate the onset of sour cherry blossom for the main growing regions in Rhineland-Palatinate (Germany) were compared. Three of the approaches were pure forcing models (M1, M2, M2DL) and the remaining four models were combined sequential chilling-forcing (CF) models. Model M1 was the commonly used growing degree day (GDD) model in which the starting date of temperature accumulation ( t 1), the base temperature ( T BF) and the forcing requirement F* were optimized on the basis of observed data. Because of a relatively late optimal starting date ( t 1 = 1 March), the model can be applied only to calculate the onset of cherry blossom for present climate conditions. In order to develop forcing models that could possibly be used to estimate possible shifts in the timing of cherry blossom due to climate change, the starting date t 1 of the models was intentionally set to 1 January (M2, M2DL). Unfortunately, model M2 failed in both the optimization and validation period. The introduction of a daylength term (DL) in model M2DL improved model performance. In order to project possible shifts in the timing of plant phenological events, combined CF-models are preferred over pure GDD-models. For this reason four CF-models were developed with (M3DL, M4DL) and without (M3, M4) consideration of daylength in the GDD-approach. The chilling requirement was calculated using chilling hours (M3, M3DL) and chill portions (M4, M4DL). Both models without daylength estimated implausible model parameters and failed model validation. However, models M3DL and M4DL showed meaningful model parameter estimations and the error between modelled and observed data was markedly reduced. Moreover, the models optimized and validated (internal validation) for one sour cherry growing region in Germany, were applied successfully to calculate the beginning of the blossom period in other regions in Europe and even at one station in North America (external validation).

  18. Human life history evolution explains dissociation between the timing of tooth eruption and peak rates of root growth. (United States)

    Dean, M Christopher; Cole, Tim J


    We explored the relationship between growth in tooth root length and the modern human extended period of childhood. Tooth roots provide support to counter chewing forces and so it is advantageous to grow roots quickly to allow teeth to erupt into function as early as possible. Growth in tooth root length occurs with a characteristic spurt or peak in rate sometime between tooth crown completion and root apex closure. Here we show that in Pan troglodytes the peak in root growth rate coincides with the period of time teeth are erupting into function. However, the timing of peak root velocity in modern humans occurs earlier than expected and coincides better with estimates for tooth eruption times in Homo erectus. With more time to grow longer roots prior to eruption and smaller teeth that now require less support at the time they come into function, the root growth spurt no longer confers any advantage in modern humans. We suggest that a prolonged life history schedule eventually neutralised this adaptation some time after the appearance of Homo erectus. The root spurt persists in modern humans as an intrinsic marker event that shows selection operated, not primarily on tooth tissue growth, but on the process of tooth eruption. This demonstrates the overarching influence of life history evolution on several aspects of dental development. These new insights into tooth root growth now provide an additional line of enquiry that may contribute to future studies of more recent life history and dietary adaptations within the genus Homo.

  19. The possibility of aromorphosis in further development of closed human life support systems using genetically modified organisms (United States)

    Gitelson, Josef

    Creation of closed systems that would be able to support human life outside the biosphere for extended periods of time (CES) was started after humans went into outer space. The last fifty years have seen the construction of experimental variants of the CES in Russia, USA, and Japan. The "MELISSA" project of the European Space Agency is being prepared to be launched. Much success has been achieved in closing material loops in the CES. An obstacle to constructing a fully closed ecosystem is significant imbalance in material exchange between the producing components and the decomposing ones in the CES. The spectrum of metabolites released by humans does not fully correspond to the requirements of the main producer of the CES -plants. However, this imbalance can be corrected by rather simple physicochemical processes that can be used in the CES without unclosing the system. The major disagreement that prevents further improvement of human life support systems (LSS) is that the spectrum of products of photosynthesis in the CES does not correspond to human food requirements qual-itatively, quantitatively, or in terms of diversity. In the normal, physiologically sound, human diet, this discrepancy is resolved by adding animal products. However, there are technical, technological, and hygienic obstacles to including animals in the closed human life support systems, and if higher animals are considered, there are also ethical arguments. If between the photoautotrophic link, plants, and the heterotrophic link, the human, there were one more heterotrophic link, farm animals, the energy requirements of the system would be increased by nearly an order of magnitude, decreasing its efficiency and making it heavier and bulkier. Is there another way to close loops in human life support systems? In biology, such "findings" of evolution, which open up new perspectives and offer ample opportunities for possible adapta-tions, are termed aromorphoses (Schmalhausen, 1948). In further

  20. Social relationships and physiological determinants of longevity across the human life span. (United States)

    Yang, Yang Claire; Boen, Courtney; Gerken, Karen; Li, Ting; Schorpp, Kristen; Harris, Kathleen Mullan


    Two decades of research indicate causal associations between social relationships and mortality, but important questions remain as to how social relationships affect health, when effects emerge, and how long they last. Drawing on data from four nationally representative longitudinal samples of the US population, we implemented an innovative life course design to assess the prospective association of both structural and functional dimensions of social relationships (social integration, social support, and social strain) with objectively measured biomarkers of physical health (C-reactive protein, systolic and diastolic blood pressure, waist circumference, and body mass index) within each life stage, including adolescence and young, middle, and late adulthood, and compare such associations across life stages. We found that a higher degree of social integration was associated with lower risk of physiological dysregulation in a dose-response manner in both early and later life. Conversely, lack of social connections was associated with vastly elevated risk in specific life stages. For example, social isolation increased the risk of inflammation by the same magnitude as physical inactivity in adolescence, and the effect of social isolation on hypertension exceeded that of clinical risk factors such as diabetes in old age. Analyses of multiple dimensions of social relationships within multiple samples across the life course produced consistent and robust associations with health. Physiological impacts of structural and functional dimensions of social relationships emerge uniquely in adolescence and midlife and persist into old age.

  1. Impact of Gender Binarism on Hijras' Life Course and Their Access to Fundamental Human Rights in Pakistan. (United States)

    Alizai, Aurangzaib; Doneys, Philippe; Doane, Donna L


    This study adds to the growing body of knowledge on gender nonconformity aspects of heteronormativity by examining its impact on the life course of hijras and their access to fundamental human rights in Pakistan. Drawing on 50 semistructured interviews conducted in two sites, the findings suggest that the participants' lived experiences associated with gender nonconformity significantly influenced the direction of their life course and their ability to have access to human rights. These experiences spanned from childhood to elderhood across a wide range of settings, such as family, school, guru dera (residence headed by a hijra guru), workplace, and interactions with authorities. The participants' human rights were not recognized, resulting in abuse, social stigma, discrimination against them, and their exclusion from mainstream society. Finally, implications are drawn for public policy and future research on third gender concerns in Pakistan and elsewhere.

  2. The Map of My Life

    CERN Document Server

    Shimura, Goro


    Tells about the author's life, beginning with his earliest childhood days. This book describes his survival of American bombing raids when he was a teenager in Japan, his emergence as a researcher in a post-war university system that was seriously deficient, and his life as a mathematician in Princeton and in the international academic community.

  3. Red palm oil: nutritional, physiological and therapeutic roles in improving human wellbeing and quality of life. (United States)

    Oguntibeju, O O; Esterhuyse, A J; Truter, E J


    The link between dietary fats and cardiovascular disease has created a growing interest in dietary red palm oil research. Also, the link between nutrition and health, oxidative stress and the severity or progression of disease has stimulated further interest in the potential role of red palm oil (a natural antioxidant product) to improve oxidative status by reducing oxidative stress in patients with cardiovascular disease, cancer and other chronic diseases. In spite of its level of saturated fatty acid content (50%), red palm oil has not been found to promote atherosclerosis and/or arterial thrombosis. This is probably due to the ratio of its saturated fatty acid to unsaturated fatty acid content and its high concentration of antioxidants such as beta-carotene, tocotrienols, tocopherols and vitamin E. It has also been reported that the consumption of red palm oil reduces the level of endogenous cholesterol, and this seems to be due to the presence of the tocotrienols and the peculiar isomeric position of its fatty acids. The benefits of red palm oil to health include a reduction in the risk of arterial thrombosis and/or atherosclerosis, inhibition of endogenous cholesterol biosynthesis, platelet aggregation, a reduction in oxidative stress and a reduction in blood pressure. It has also been shown that dietary red palm oil, taken in moderation in animals and humans, promotes the efficient utilisation of nutrients, activates hepatic drug metabolising enzymes, facilitates the haemoglobinisation of red blood cells and improves immune function. This review provides a comprehensive overview of the nutritional, physiological and biochemical roles of red palm oil in improving wellbeing and quality of life.

  4. Climate and Life: A Human Retrospective. (United States)

    deMenocal, P. B.


    A renaissance scientist, Cesare Emiliani was also interested in climate change and its influence on human origins, ancient cultures, and our future. Climate shapes life across a range of time and space scales - seasons pace the cycle of death and renewal, and the diversity of all life is bounded by latitude. Each of the "big five" mass extinctions of the Phanerozoic is linked to environmental crisis. Has climate change also shaped us? Analytical advances, new sediment archives, and heroic international collaborations have brought new light to this question. Gone is the dated view of our ancestors emerging from some ancient dark forest to assert dominion over the grassy plains. In its place is new evidence for rapid and large orbital-scale climate cycles that shifted, stepwise after 2.8 and then again after 1.8 million years ago to establish the African savannah we know today. These climate events are coincident with clusters of hominin speciation, extinction, and behavioral innovation milestones that came to define us as human. The African Humid Period is one of the best and oldest examples of human cultural responses to climate change. Between 15,000-5,000 years ago the Saharan desert supported grassy, wooded plains, large lakes, and clusters of human settlements due to orbital increases in monsoonal rainfall. While there is an ongoing debate whether the end of this wet phase was fast (centuries) or slow (millennia), the rich archeological record shows that this region was depopulated and, within centuries, the first settlements appear along the Nile River near 5 ka BP. Many "firsts" are associated with these predynastic cultures of the Naqada III Period including the first named kings, pyramids, and hieroglyphs, resulting in political unification and Dynastic rule along the Nile. As these diverse lines of evidence come together, it appears as if an answer to the age-old question "How did I get here?" is no longer beyond our reach. Climate has played an important

  5. The End of the Beginning: Cell Death in the Germline. (United States)

    Peterson, Jeanne S; Timmons, Allison K; Mondragon, Albert A; McCall, Kimberly


    Programmed cell death occurs in the germline of many organisms, both as an essential part of development and throughout adult life. Germline cell death can be apoptotic or nonapoptotic, depending on the stimulus or stage of development. Here, we focus on the Drosophila ovary, which is a powerful model for studying diverse types of cell death. In Drosophila, the death of primordial germ cells occurs normally during embryonic development, and germline nurse cells are programmed to die during oocyte development in adult flies. Cell death of previtellogenic egg chambers in adults can also be induced by starvation or other environmental cues. Mid-oogenesis seems to be particularly sensitive to such cues and has been proposed to serve as a checkpoint to avoid the energetically expensive cost of egg production. After the germline dies in mid-oogenesis, the remnants are engulfed by an epithelial layer of follicle cells; thus, the fly ovary also serves as a highly tractable model for engulfment by epithelial cells. These examples of cell death in the fly ovary share many similarities to the types of cell death seen in the mammalian germline. Recent progress in elucidating the molecular mechanisms of cell death in the germline is discussed. © 2015 Elsevier Inc. All rights reserved.

  6. [People, the environment and health: the "Oneness" of human health from the perspective of universal life presented in "Changes"]. (United States)

    Yang, Ke-Ping


    This paper aimed to expand the paradigm of nursing and expand the essential factors of nursing theories beyond "environment" to encompass universal life. While individuals live between the sky and earth, we are an inseparable part of the universe. "Health" is derived from a oneness that embraces the body, mind and spirit. The human body contains the wisdom of the universe, known in Chinese philosophy as the wisdom of "Changes". The body has its own consciousness and possesses great powers of self-healing. Healthiness is the original condition of life. Modern medicine assumes sickness to be a natural phenomenon, with the essential nature of "Changes" neglected as a universal law for maintaining health. Dr. Sun, a renowned physician from the Tang Dynasty, was quoted as saying "Knowing Changes is the prerequisite of knowing medicine." Another saying holds that, "Every word and every sentence in the Book of Changes is an indicator of medicine." Much emphasis has been placed on the relationship between "Changes" and "medicine" in the past. This paper elaborates the relationship between nature and human health in order to provide a clear understanding of the nature of true health, described from the perspectives of medicine and "Changes", an evaluation of modern medical science and the oneness of body-mind-spirit, which is the reality of health. The human body is thus a reflection of the mind and spirit, while the mind and spirit is the "inner body". The body is a highly intelligent organism that truly reflects our inner world. Our inner world is also displayed through physical symptoms. As human suffering is caused by separation from our inner life, the only path to enjoying a healthy and joyful life is to achieve a oneness between our body-mind-spirit. Such is a universal law, which is called "Changes" or "Oneness".

  7. Optimization of controlled environments for hydroponic production of leaf lettuce for human life support in CELSS (United States)

    Mitchell, C. A.; Knight, S. L.; Ford, T. L.


    A research project in the food production group of the Closed Ecological Life Support System (CELSS) program sought to define optimum conditions for photosynthetic productivity of a higher plant food crop. The effects of radiation and various atmospheric compositions were studied.

  8. Quality of life, socioeconomic profile, knowledge and attitude toward sexuality from the perspectives of individuals living with Human Immunodeficiency Virus

    Directory of Open Access Journals (Sweden)

    Meiry Fernanda Pinto Okuno


    Full Text Available Objectives: to analyze the quality of life of "patients" with Human Immunodeficiency Virus and relate it to their socioeconomic profile, knowledge and attitudes toward sexuality. Method: crosssectional and analytical study with 201 individuals who are 50 years old or older. The Targeted Quality of Life and Aging Sexual Knowledge and Attitudes Scales were applied during interviews. Multiple Linear Regression was used in data analysis. Results: dimensions of quality of life more strongly compromised were disclosure worries (39.0, sexual function (45.9, and financial worries (55.6. Scores concerning knowledge and attitudes toward sexuality were 31.7 and 14.8, respectively. There was significant correlation between attitudes and the domains of overall function, health worries, medication worries, and HIV mastery. Conclusion: guidance concerning how the disease is transmitted, treated and how it progresses, in addition to providing social and psychological support, could minimize the negative effects of the disease on the quality of life of patients living with the Human Immunodeficiency Virus.

  9. Placing Human Behavior at the Center of the Fight to Eradicate Polio: Lessons Learned and Their Application to Other Life-Saving Interventions. (United States)

    Guirguis, Sherine; Obregon, Rafael; Coleman, Michael; Hickler, Benjamin; SteelFisher, Gillian


    Today, acceptance of oral polio vaccine is the highest ever. Reaching this level of acceptance has depended on decades of engaging with communities, building trust amid extraordinary social contexts, and responding to the complex variables that trigger behavioral and social change. Drawing on both the successes and setbacks in the 28 years of the Global Polio Eradication Initiative (GPEI), this article articulates what happened when the GPEI began to pay more attention to the dynamics of human and social behavior change. Three particular lessons for other health and immunization programs can be drawn from the experience of GPEI: change begins from within (ie, success needs institutional recognition of the importance of human behavior), good data are not enough for good decision-making, and health workers are important agents of behavior change. These lessons should be harnessed and put into practice to build demand and trust for the last stages of polio eradication, as well as for other life-saving health interventions. © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America.

  10. Leaching potential of nanomaterials during different human contact scenarios and end-of-life

    DEFF Research Database (Denmark)

    Hansen, Steffen Foss; Mackevica, Aiga; Heggelund, Laura Roverskov


    In order to understand how much, when and by which mechanisms nanomaterials are released during the life cycle of a given application, we have experimentally investigated the release of nanoparticles (NP) from a wide range of products. These include silver and titanium dioxide NP released from food...... of the life cycle seem to be especially important and not well understood. In order to get an estimation of the overall release potential of nanomaterials during the consumer use phase and the waste phase, we also mapped consumer products on the EU marked claiming to be nano-enabledand commercially available...... online (see as well as the waste flows of these consumer products. We identified more than 1275 products to be available in the EU. Almost 200 products of these are claimed to contain nanosilver, but for more than 800 products the identity of the nanomaterial used was not reported. Based...

  11. Overview: Using Mode of Action and Life Stage Information to Evaluate the Human Relevance of Animal Toxicity Data

    Energy Technology Data Exchange (ETDEWEB)

    Seed, Jennifer; Carney, E W.; Corley, Rick A.; Crofton, Kevin M.; DeSesso, John M.; Foster, Paul M.; Kavlock, Robert; Kimmel, Gary; Klaunig, James E.; Meek, M E.; Preston, R J.; Slikker, William; Tabacova, Sonia; Williams, Gary M.; Wiltse, J; Zoeller, R T.; Fenner-Crisp, P; Patton, D E.


    A complete mode of action human relevance analysis--as distinct from mode of action (MOA) analysis alone--depends on robust information on the animal MOA, as well as systematic comparison of the animal data with corresponding information from humans. In November 2003, the International Life Sciences Institute's Risk Science Institute (ILSI RSI) published a 2-year study using animal and human MOA information to generate a four-part Human Relevance Framework (HRF) for systematic and transparent analysis of MOA data and information. Based mainly on non-DNA-reactive carcinogens, the HRF features a ''concordance'' analysis of MOA information from both animal and human sources, with a focus on determining the appropriate role for each MOA data set in human risk assessment. With MOA information increasingly available for risk assessment purposes, this article illustrates the further applicability of the HRF for reproductive, developmental, neurologic, and renal endpoints, as well as cancer. Based on qualitative and quantitative MOA considerations, the MOA/human relevance analysis also contributes to identifying data needs and issues essential for the dose-response and exposure assessment steps in the overall risk assessment.

  12. The influence of life history and sexual dimorphism on entheseal changes in modern humans and African great apes. (United States)

    Milella, Marco


    Entheseal changes have been widely studied with regard to their correlation to biomechanical stress and their usefulness for biocultural reconstructions. However, anthropological and medical studies have demonstrated the marked influence of both age and sex on the development of these features. Studies of entheseal changes are mostly aimed in testing functional hypotheses and are mostly focused on modern humans, with few data available for non-human primates. The lack of comparative studies on the effect of age and sex on entheseal changes represent a gap in our understanding of the evolutionary basis of both development and degeneration of the human musculoskeletal system. The aim of the present work is to compare age trajectories and patterns of sexual dimorphism in entheseal changes between modern humans and African great apes. To this end we analyzed 23 postcranial entheses in a human contemporary identified skeletal collection (N = 484) and compared the results with those obtained from the analysis of Pan (N = 50) and Gorilla (N = 47) skeletal specimens. Results highlight taxon-specific age trajectories possibly linked to differences in life history schedules and phyletic relationships. Robusticity trajectories separate Pan and modern humans from Gorilla, whereas enthesopathic patterns are unique in modern humans and possibly linked to their extended potential lifespan. Comparisons between sexes evidence a decreasing dimorphism in robusticity from Gorilla, to modern humans to Pan, which is likely linked to the role played by size, lifespan and physical activity on robusticity development. The present study confirms previous hypotheses on the possible relevance of EC in the study of life history, pointing moreover to their usefulness in evolutionary studies.

  13. Evolution of life history and behavior in Hominidae: towards phylogenetic reconstruction of the chimpanzee-human last common ancestor. (United States)

    Duda, Pavel; Zrzavý, Jan


    The origin of the fundamental behavioral differences between humans and our closest living relatives is one of the central issues of evolutionary anthropology. The prominent, chimpanzee-based referential model of early hominin behavior has recently been challenged on the basis of broad multispecies comparisons and newly discovered fossil evidence. Here, we argue that while behavioral data on extant great apes are extremely relevant for reconstruction of ancestral behaviors, these behaviors should be reconstructed trait by trait using formal phylogenetic methods. Using the widely accepted hominoid phylogenetic tree, we perform a series of character optimization analyses using 65 selected life-history and behavioral characters for all extant hominid species. This analysis allows us to reconstruct the character states of the last common ancestors of Hominoidea, Hominidae, and the chimpanzee-human last common ancestor. Our analyses demonstrate that many fundamental behavioral and life-history attributes of hominids (including humans) are evidently ancient and likely inherited from the common ancestor of all hominids. However, numerous behaviors present in extant great apes represent their own terminal autapomorphies (both uniquely derived and homoplastic). Any evolutionary model that uses a single extant species to explain behavioral evolution of early hominins is therefore of limited use. In contrast, phylogenetic reconstruction of ancestral states is able to provide a detailed suite of behavioral, ecological and life-history characters for each hypothetical ancestor. The living great apes therefore play an important role for the confident identification of the traits found in the chimpanzee-human last common ancestor, some of which are likely to represent behaviors of the fossil hominins. Copyright © 2013 Elsevier Ltd. All rights reserved.

  14. Impacts of “metals” on human health: uncertainties in using different Life Cycle Impact Assessment (LCIA) methodologies

    DEFF Research Database (Denmark)

    Pizzol, Massimo; Christensen, Per; Schmidt, Jannick Højrup

    This study looks into the uncertainties in determining the impact of “metals” emissions to human health, in Life Cycle Impact Assessment (LCIA). Metals are diverse substances, with different proprieties and characteristics, considered important in LCIA because of their toxicity to humans...... be considered in an impact assessment focused on human health, and defined a list of 14 metals. We performed a contribution analysis in order to compare methods in relative terms; an approach successfully used in other studies. Various processes have been analyzed with 8 different LCIA methods in order...... to assess both how much each metal contributes to the total impact on human health, when only metal emissions are present, and how much metals in total contribute when also other toxic substances are included in the inventory of emissions. Differences between the methods are great and due...

  15. Golf science research at the beginning of the twenty-first century. (United States)

    Farrally, M R; Cochran, A J; Crews, D J; Hurdzan, M J; Price, R J; Snow, J T; Thomas, P R


    At the beginning of the twenty-first century, there are 30,000 golf courses and 55 million people who play golf worldwide. In the USA alone, the value of golf club memberships sold in the 1990s was US dollar 3.2 billion. Underpinning this significant human activity is a wide variety of people researching and applying science to sustain and develop the game. The 11 golf science disciplines recognized by the World Scientific Congress of Golf have reported 311 papers at four world congresses since 1990. Additionally, scientific papers have been published in discipline-specific peer-reviewed journals, research has been sponsored by the two governing bodies of golf, the Royal and Ancient Golf Club of St. Andrews and the United States Golf Association, and confidential research is undertaken by commercial companies, especially equipment manufacturers. This paper reviews much of this human endeavour and points the way forward for future research into golf.

  16. Towards a Pedagogy of Listening: Teaching and Learning from Life Stories of Human Rights Violations (United States)

    Low, Bronwen E.; Sonntag, Emmanuelle


    In response to the task of designing curriculum that helps youth engage thoughtfully with digital stories of human rights violations, the authors articulate the central tenets of a pedagogy of listening that draws upon elements of oral history, concepts of witnessing and testimony, the work on listening of Dewey, Freire and Rinaldi and the…

  17. The right to life and criminal-law protection of the human person in the Western Balkans

    Directory of Open Access Journals (Sweden)

    Etlon Peppo


    Full Text Available The basic principle for which a democratic governance stands, are expressed in the “Declaration of Independence of the United States of America with the words of Thomas Jefferson: “We hold these truths to be self-evident, that all men are created equal, that they are endowed by their Creator with certain unalienable Rights that among these are Life, Liberty and the Pursuit of Happiness. That to secure these rights, Governments are instituted among Men, deriving their just powers from the consent of the governed” The government of a democratic state does not exist to recognize the basic human rights, but to respect and guarantee the protection of these rights that any person possesses and benefits due to his existence starting from the most important right: The right to life, which is faced against the duty of the state for the protection of the human person’s life! In this sense this article analyzes the criminal-law protection of life in the Western Balkans.

  18. Imposition of a delay prior to beginning radiotherapy: impact on mood states for cancer patients

    International Nuclear Information System (INIS)

    Merker, R.A.


    Waiting lists for radiotherapy are a recent phenomenon in highly populated areas and, coupled with the public's awareness of the nature of cancer and the need for immediate treatment, a psychological dilemma has emerged. Since virtually all patients are now assigned to the radiotherapy waiting list, a random sample of patients who would begin radiotherapy immediately following their initial consultation was created. Quality of life, in terms of self-reported mood indices, was assessed at five points in time for each patient using the Profile of Mood States. Approximately 25% of the delayed patients chose to leave the waiting list and seek treatment elsewhere. The most striking finding was that patients who began radiotherapy immediately experienced improved quality of life during the course of treatment as per Forester, et al., (1985). In contrast, the patients who spent time (1-8 weeks) on a treatment waiting list experienced a decrease in quality of life over their course of radiotherapy and even more so at a month following the end of treatment

  19. Quality of life technologies

    DEFF Research Database (Denmark)

    Wac, Katarzyna; Fiordelli, M.; Gustarini, M.


    Inevitably, as basic human needs are assured in any developed society, differentiating factors for quality of life (QoL) relate to a greater capacity to make informed decisions across daily life activities, especially those related to health. The availability of powerful, personalized, and wearable...

  20. A landslide on a mudslide? Natural hazards and the right to life under the European Convention of Human Rights

    DEFF Research Database (Denmark)

    Lauta, Kristian Cedervall; Rytter, Jens Elo


    This paper investigates the protection of individuals’ lives against natural hazards under the European Convention on Human Rights. In 2008, the European Court of Human Rights decided to include natural hazards in a well-established doctrine developed to protect individuals from life......-threatening industrial hazards, while allowing States an especially broad margin of appreciation with regard to natural hazards. Drawing on contemporary disaster theory, the article examines whether and to what extent the Court's distinction between natural and industrial hazards can be maintained. The article proposes...

  1. Role of stable isotope analyses in reconstructing past life-histories and the provenancing human skeletal remains: a review

    Directory of Open Access Journals (Sweden)

    Sehrawat Jagmahender Singh


    Full Text Available This article reviews the present scenario of use of stable isotopes (mainly δ13C, δ15N, δ18O, 87Sr to trace past life behaviours like breast feeding and weaning practices, the geographic origin, migration history, paleodiet and subsistence patterns of past populations from the chemical signatures of isotopes imprinted in human skeletal remains. This approach is based on the state that food-web isotopic signatures are seen in the human bones and teeth and such signatures can change parallely with a variety of biogeochemical processes. By measuring δ13C and δ15N isotopic values of subadult tissues of different ages, the level of breast milk ingestion at particular ages and the components of the complementary foods can be assessed. Strontium and oxygen isotopic analyses have been used for determining the geographic origins and reconstructing the way of life of past populations as these isotopes can map the isotopic outline of the area from where the person acquired water and food during initial lifetime. The isotopic values of strontium and oxygen values are considered specific to geographical areas and serve as reliable chemical signatures of migration history of past human populations (local or non-local to the site. Previous isotopic studies show that the subsistence patterns of the past human populations underwent extensive changes from nomadic to complete agricultural dependence strategies. The carbon and nitrogen isotopic values of local fauna of any archaeological site can be used to elucidate the prominence of freshwater resources in the diet of the past human populations found near the site. More extensive research covering isotopic descriptions of various prehistoric, historic and modern populations is needed to explore the role of stable isotope analysis for provenancing human skeletal remains and assessing human migration patterns/routes, geographic origins, paleodiet and subsistence practices of past populations.

  2. In the beginning was information

    CERN Document Server

    Gitt, Werner, Dr


    Information is the cornerstone of life, yet it is something people don't often think about. In his fascinating new book, In the Beginning Was Information, Dr. Werner Gitt helps the reader see how the very presence of information reveals a Designer.

  3. Männerbund: Theory and reality in Germany at the beginning of 20.Century

    Directory of Open Access Journals (Sweden)

    Molnar Aleksandar I.


    Full Text Available In the article the author is dealing with the connection between the renaissance of the unions of men (Männerbünde and rise of scientific interest in such forms of social life in the early 20th Century Germany. Although new forms of Männerbünde were not entirely adequate to the old forms, there is no doubt that all main features of militant Männerbünde were present at the beginning of Weimar republic: the cult of youth, ecstatic experiences, elitist conciseness, as well as tendency towards open and rough violence. Author‘s intention is to stress the importance of the role that Männerbünde played in the early phase of German revolution - especially in provoking civil war, spreading hatred towards modern (i.e. "Western" civilization, reviving old militant German traditions, fighting democracy and undermining the fragile foundations of Weimar republic.

  4. Development of Human Resources Using New Technologies in Long-Life Learning

    Directory of Open Access Journals (Sweden)

    Micu Bogdan Ghilic


    Full Text Available Information and communication technologies (ICT offer new opportunities to reinvent the education and to make people and makes learning more fun and contemporary but poses many problems to educational institutions. Implementation of ICT determines major structural changes in the organizations and mental switch from bureaucratic mentality to customer-oriented one. In this paper I try to evaluate methods of developing the lifelong learning programs, impact to human resources training and development and the impact of this process on educational institutions. E-learning usage in training the human resources can make a new step in development of the education institutions, human resources and companies.

  5. A life course perspective on migration and mental health among Asian immigrants: the role of human agency. (United States)

    Gong, Fang; Xu, Jun; Fujishiro, Kaori; Takeuchi, David T


    The relationship between human agency and health is an important yet under-researched topic. This study uses a life course perspective to examine how human agency (measured by voluntariness, migratory reasons, and planning) and timing (measured by age at immigration) affect mental health outcomes among Asian immigrants in the United States. Data from the National Latino and Asian American Study showed that Asian immigrants (n=1491) with multiple strong reasons to migrate were less likely to suffer from mental health problems (i.e., psychological distress and psychiatric disorders in the past 12 months) than those without clear goals. Moreover, Asian immigrants with adequate migratory planning had lower levels of distress and lower rates of 12-month psychiatric disorders than those with poorly planned migration. Compared with migrants of the youngest age category (six or younger), those who migrated during preteen and adolescent years without clear goals had higher levels of psychological distress, and those who migrated during adulthood (25 years or older) were less likely to suffer from recent depressive disorders (with the exception of those migrating for life-improving goals). Furthermore, we found that well-planned migration lowered acculturative stress, and multiple strong reasons for migration buffered the negative effect of acculturative stress upon mental health. Findings from this study advance research on immigrant health from the life course perspective by highlighting the effects of exercising human agency during the pre-migration stage upon post-migration mental health. Copyright © 2011 Elsevier Ltd. All rights reserved.

  6. The beginning of the end for chimpanzee experiments?

    Directory of Open Access Journals (Sweden)

    Knight Andrew


    chimpanzees, and other research fields presently deprived of funding, but would also increase the compliance of US animal researchers with internationally-accepted animal welfare and bioethical standards. It could even result in the first global moratorium on invasive research, for any non-human species, unless conducted in the best interests of the individual or species.

  7. The beginning of the end for chimpanzee experiments? (United States)


    fields presently deprived of funding, but would also increase the compliance of US animal researchers with internationally-accepted animal welfare and bioethical standards. It could even result in the first global moratorium on invasive research, for any non-human species, unless conducted in the best interests of the individual or species. PMID:18518999

  8. The influence of the level of physical activity and human development in the quality of life in survivors of stroke

    Directory of Open Access Journals (Sweden)

    Hickner Robert C


    Full Text Available Abstract Background The association between physical activity and quality of life in stroke survivors has not been analyzed within a framework related to the human development index. This study aimed to identify differences in physical activity level and in the quality of life of stroke survivors in two cities differing in economic aspects of the human development index. Methods Two groups of subjects who had suffered a stroke at least a year prior to testing and showed hemiplegia or hemiparesis were studied: a group from Belo Horizonte (BH with 48 people (51.5 ± 8.7 years and one from Montes Claros (MC with 29 subjects (55.4 ± 8.1 years. Subsequently, regardless of location, the groups were divided into Active and Insufficiently Active so their difference in terms of quality of life could be analyzed. Results There were no significant differences between BH and MCG when it came to four dimensions of physical health that were evaluated (physical functioning, physical aspect, pain and health status or in the following four dimensions of mental health status (vitality, social aspect, emotional aspect and mental health. However, significantly higher mean values were found in Active when compared with Insufficiently Active individuals in various measures of physical health (physical functioning 56.2 ± 4.4 vs. 47.4 ± 6.9; physical aspect 66.5 ± 6.5 vs. 59.1 ± 6.7; pain 55.9 ± 6.2 vs. 47.7 ± 6.0; health status 67.2 ± 4.2 vs. 56.6 ± 7.8 (arbitrary units, and mental health (vitality 60.9 ± 6.8 vs. 54.1 ± 7.2; social aspect 60.4 ± 7.1 vs. 54.2 ± 7.4; emotional aspect 64.0 ± 5.5 vs. 58.1 ± 6.9; mental health status 66.2 ± 5.5 vs. 58.4 ± 7.5 (arbitrary units. Conclusions Despite the difference between the cities concerning HDI values, no significant differences in quality of life were found between BH and MCG. However, the Active group showed significantly better results, confirming the importance of active lifestyle to enhance quality of

  9. The influence of the level of physical activity and human development in the quality of life in survivors of stroke. (United States)

    Aidar, Felipe J; de Oliveira, Ricardo J; Silva, António J; de Matos, Dihogo G; Carneiro, André L; Garrido, Nuno; Hickner, Robert C; Reis, Victor M


    The association between physical activity and quality of life in stroke survivors has not been analyzed within a framework related to the human development index. This study aimed to identify differences in physical activity level and in the quality of life of stroke survivors in two cities differing in economic aspects of the human development index. Two groups of subjects who had suffered a stroke at least a year prior to testing and showed hemiplegia or hemiparesis were studied: a group from Belo Horizonte (BH) with 48 people (51.5 ± 8.7 years) and one from Montes Claros (MC) with 29 subjects (55.4 ± 8.1 years). Subsequently, regardless of location, the groups were divided into Active and Insufficiently Active so their difference in terms of quality of life could be analyzed. There were no significant differences between BH and MCG when it came to four dimensions of physical health that were evaluated (physical functioning, physical aspect, pain and health status) or in the following four dimensions of mental health status (vitality, social aspect, emotional aspect and mental health). However, significantly higher mean values were found in Active when compared with Insufficiently Active individuals in various measures of physical health (physical functioning 56.2 ± 4.4 vs. 47.4 ± 6.9; physical aspect 66.5 ± 6.5 vs. 59.1 ± 6.7; pain 55.9 ± 6.2 vs. 47.7 ± 6.0; health status 67.2 ± 4.2 vs. 56.6 ± 7.8) (arbitrary units), and mental health (vitality 60.9 ± 6.8 vs. 54.1 ± 7.2; social aspect 60.4 ± 7.1 vs. 54.2 ± 7.4; emotional aspect 64.0 ± 5.5 vs. 58.1 ± 6.9; mental health status 66.2 ± 5.5 vs. 58.4 ± 7.5) (arbitrary units). Despite the difference between the cities concerning HDI values, no significant differences in quality of life were found between BH and MCG. However, the Active group showed significantly better results, confirming the importance of active lifestyle to enhance quality of life in stroke survivors.

  10. Teaching Beginning Trombone Players. (United States)

    Fallis, Todd L.


    Discusses the process of introducing the trombone to beginning students and addresses the issue of warming-up. Provides resources for beginning trombone methods, band methods, and daily warm-up studies. Includes resources for scale studies and etudes for beginning to intermediate trombone players. (CMK)

  11. Scattered Families : Transnational family life of Afghan refugees in the Netherlands in the light of the human rights based protection of the family

    NARCIS (Netherlands)

    Muller, P.H.A.M


    This study focuses on family life of Afghan refugees in the Netherlands, within and across borders. While family life constitutes a foundation in the lives of human beings, the disruption of the family through external causes has a huge impact on the people involved. In the case of refugees, many of

  12. Indicators for human toxicity in Life Cycle Impact Assessment

    DEFF Research Database (Denmark)

    Krewitt, Wolfram; Pennington, David W.; Olsen, Stig Irving


    The main objectives of this task group under SETAC-Europe’s Second Working Group on Life Cycle Impact Assessment (LCIA-WIA2) were to identify and discuss the suitability of toxicological impact measures for human health for use in characterization in LCIA. The current state of the art of defining......, as well as potency. Quantitative severity-based indicators yield measures in terms of Years of Life Lost (YOLL), Disability Adjusted Life Years (DALY), Quality Adjusted Life Years (QALY) and other similar measures. DALYs and QALYs are examples of approaches that attempt to account for both years of life...... lost (mortality) and years of impaired life (morbidity). Qualitative severity approaches tend to arrange potency-based indicators in categories, avoiding the need to quantitatively express differences in severity. Based on the proposed criteria and current state of the knowledge, toxicological potency...

  13. The Sanctity of human life. A perspective from New Testament anthropology

    Directory of Open Access Journals (Sweden)

    H C. van Zyl


    Full Text Available The article deals with sanctity of life issues such as abortion, euthanasia, treatment of the disabled, war, and capital punishment. These matters are not treated individually but collectively from the perspective of New Testament anthropology. Having taken care of a few methodological considerations, the main focus falls on a discussion of man as sinner, man in Christ, and the category of the least.

  14. Helping homeless men begin a new life. A program on Chicago's West Side provides substance abuse rehabilitation and job training. (United States)

    Maher, J; Peck, T


    The MARSEPH program, named for the two principal program collaborators--the Marillac Social Center and Saint Joseph Health Centers and Hospital--provides life and work skills to homeless men who visit a day shelter operated by the Marillac Social Center. Participants gain work experience at Saint Joseph. One of the most important aspects of the MARSEPH program is the removal of obstacles to the newly employed. Each MARSEPH participant receives housing assistance, a uniform, transportation to Saint Joseph Health Centers and Hospital, and a meal pass to the hospital's cafeteria. Through this assistance, the men can get off the streets, get to their jobs, be nourished, and look presentable. The MARSEPH program carefully monitors each participant's progress, to ensure his success. Case workers meet weekly with the men to discuss problems and concerns. Every week case workers also visit each participant's residence to monitor his living conditions and offer emotional support. At the end of the six-month training program, MARSEPH helps graduates find employment.

  15. Categorial Ontology of Complex Systems, Meta-Systems and Levels: The Emergence of Life, Human Consciousness and Society

    Directory of Open Access Journals (Sweden)

    James F. Glazebrook


    Full Text Available Relational structures of organisms and the human mind are naturally represented in terms of novel variable topology concepts, non-Abelian categories and Higher Dimensional Algebra{ relatively new concepts that would be defined in
    this tutorial paper. A unifying theme of local-to-global approaches to organismic development, evolution and human consciousness leads to novel patterns of relations that emerge in super- and ultra- complex systems in terms of compositions of local procedures [1]. The claim is defended in this paper that human consciousness is unique and should be viewed as an ultra-complex, global process of processes, at a meta-level not sub{summed by, but compatible with, human brain dynamics [2]-[5]. The emergence of consciousness and its existence
    are considered to be dependent upon an extremely complex structural and functional unit with an asymmetric network topology and connectivities{the human brain. However, the appearance of human consciousness is shown to be critically dependent upon societal co-evolution, elaborate language-symbolic communication and `virtual', higher dimensional, non{commutative processes involving separate space and time perceptions. Theories of the mind are approached from the theory of levels and ultra-complexity viewpoints that throw
    new light on previous semantic models in cognitive science. Anticipatory systems and complex causality at the top levels of reality are discussed in the context of psychology, sociology and ecology. A paradigm shift towards non-commutative, or more generally, non-Abelian theories of highly complex dynamics [6] is suggested to unfold now in physics, mathematics, life and cognitive sciences, thus leading to the realizations of higher dimensional algebras in neurosciences and psychology, as well as in human genomics, bioinformatics and interactomics. The presence of strange attractors in modern society dynamics gives rise to very serious concerns for the future


    Directory of Open Access Journals (Sweden)

    Oana-Nicoleta Retea


    Full Text Available The name is important both to the individual and to the society. Therefore, it is important to understand its role in both shaping the private sense of self and identity and in reflecting and sustaining the social institutions such as the state, family. The aim of this article is to contribute to the better understanding of the scope of Article 8 from the European Convention of Human Rights in what concerns the right to bear a name. The great variety of issues that have been covered by this article has generated a huge literature in which Article 8 was treated as one of the most open -ended provisions of the ECHR. In this context, it was underlined the inclusion of the right to name into the domain of this article, while tracing the connotation given by the Court in the attempt to establish an infringement of the right to privacy and famil y. Moreover, the case law presented reveals that there are fluctuations in the approach of the Court, showing also the cases in which it was not found a violation of Article 8. However, the infringement of one's right to name could reveal different ways of intrusion in the private life or family life, but in any situation, it is engaged liability for the damage caused.

  17. The RIMS Beginning Teacher Support and Assessment Partnership: A Study of Eight Years of Collaboration. (United States)

    Hendrick, Linda Scott; Childress, Linda J.

    In the year 2003, the Beginning Teacher Support and Assessment Program (BTSA) will become a mandatory credentialing program for California's new teachers. At a local level, the Riverside, Inyo, Mono, San Bernardino Beginning Teacher Support and Assessment Program (RIMS/BTSA) is one of 147 BTSA programs. Now entering its eighth year, the RIMS/BTSA…

  18. Beginning Scala

    CERN Document Server

    Pollak, David


    The open source Scala language is a Java--based dynamic scripting, functional programming language. Moreover, this highly scalable scripting language lends itself well to building Cloud--based/deliverable Software as a Service (SaaS) online applications. Written by Lift Scala web framework founder and lead Dave Pollak, Beginning Scala takes a down--to--earth approach to teaching Scala that leads you through simple examples that can be combined to build complex, scalable systems and applications. This book introduces you to the Scala programming language and then guides you through Scala constr

  19. A dynamic human water and electrolyte balance model for verification and optimization of life support systems in space flight applications (United States)

    Hager, P.; Czupalla, M.; Walter, U.


    In this paper we report on the development of a dynamic MATLAB SIMULINK® model for the water and electrolyte balance inside the human body. This model is part of an environmentally sensitive dynamic human model for the optimization and verification of environmental control and life support systems (ECLSS) in space flight applications. An ECLSS provides all vital supplies for supporting human life on board a spacecraft. As human space flight today focuses on medium- to long-term missions, the strategy in ECLSS is shifting to closed loop systems. For these systems the dynamic stability and function over long duration are essential. However, the only evaluation and rating methods for ECLSS up to now are either expensive trial and error breadboarding strategies or static and semi-dynamic simulations. In order to overcome this mismatch the Exploration Group at Technische Universität München (TUM) is developing a dynamic environmental simulation, the "Virtual Habitat" (V-HAB). The central element of this simulation is the dynamic and environmentally sensitive human model. The water subsystem simulation of the human model discussed in this paper is of vital importance for the efficiency of possible ECLSS optimizations, as an over- or under-scaled water subsystem would have an adverse effect on the overall mass budget. On the other hand water has a pivotal role in the human organism. Water accounts for about 60% of the total body mass and is educt and product of numerous metabolic reactions. It is a transport medium for solutes and, due to its high evaporation enthalpy, provides the most potent medium for heat load dissipation. In a system engineering approach the human water balance was worked out by simulating the human body's subsystems and their interactions. The body fluids were assumed to reside in three compartments: blood plasma, interstitial fluid and intracellular fluid. In addition, the active and passive transport of water and solutes between those

  20. The Beginnings of the History of Philosophy in Ancient Greece

    Directory of Open Access Journals (Sweden)

    Ignacija J. Fridl


    Full Text Available Like many contemporary researchers into the ancient history of philosophy and into encyclopedic Hellenistic works (Mejer, Schoefield, Runia, Maasfeld ..., the author observes that a great deal of research into ancient doxography and Diogenes Laertius has focused on evaluation. Her own paper, on the other hand, turns to the question: What can Laertius’ attention to philosophers’ biographies in his Lives and Opinions of Eminent Philosophers tell us about the Ancient Greek view of the philosophical thought from the past?  As noted by the author, the term ‘doxography’ itself, which bears the connotation of a less reliable source and is applied today to almost every ancient explanation of any philosophical doctrine, was established by Hermann Diels as late as the 19th century. Yet this view of earlier thought was in fact already developed by Aristotle. His treatise On the Soul defines the philosophical tenets of his precursors as ‘opinions’, which are then critically examined and rejected. This attitude to earlier philosophy informs all Aristotle’s writings and his methodology of philosophy in general, for his prima philosophia as a ‘science which considers the truth’ is founded precisely on the critique of earlier thought. He critically evaluates even the tenets of his teacher Plato, in order to surpass him with his own philosophy. Thus he lays the foundations of evolutionary historiography, which perceives history as a spiritual progress and has lasted through Hegel, Marx, and – with a negative historical connotation – Heidegger – to this day. Plato, by contrast, envisages, through the very form of the dialogue, the relation to earlier philosophy as a conversation, a constant interweaving and fertilisation of one’s own thought with the wisdom of one’s precursors. This perception is further reinforced by his doctrine of knowledge as a process of remembering, that is, of philosophy as a road to wisdom leading back

  1. On the beginnings of the Constantinopolitan School of embroidery

    Directory of Open Access Journals (Sweden)

    Papastavrou Elena


    Full Text Available This paper examines Greek-Orthodox ecclesiastical embroidery in Ottoman Constantinople after 1453 until the emergence of the Constantinopolitan School of embroidery. We are well informed about the artistic production that flourished between the last decades of the seventeenth century and midnineteenth century via preserved artifacts and inscriptions bearing the embroiderers’ signature. Nevertheless, our knowledge of the production between the fall of Byzantium and the last decades of the seventeenth century is lacking. In this paper, our aim is to evaluate whether the Byzantine artistic tradition continued to live in the Greek Constantinopolitan production. The iconographical and technical analysis of different artifacts will give the answer to this question revealing at the same time the foundation basis of the embroidery of that School.

  2. Disease specific stress of tumor patients at the beginning of radiotherapy. Effect on psychosocial support requirement

    International Nuclear Information System (INIS)

    Sehlen, S.; Hollenhorst, H.; Schymura, B.; Firsching, M.; Duehmke, E.; Herschbach, P.


    Purpose: Radiotherapy brings a tumor patient into a special life situation in which different variables play a role of often unknown importance. The goal of this study was to investigate disease specific stress of tumor patients at the beginning of radiotherapy with established psychodiagnostic questionnaires and to evaluate the effect on psychosocial support requirement in order to reduce stress and to improve quality of life and compliance during radiotherapeutical treatment. Patients and Methods: 732 patients were screened, of whom 446 (60.9%) fulfilled the criteria for inclusion (refusals 21.0%, low Karnofsky performance status 6.6%, management problems 3.4%, language barriers 3.0%, cognitive restrictions 2.6%, death 2.5%). Disease specific aspects of stress in the questionnaire (Fragebogen zur Belastung von Krebspatienten, FBK), life situation (LS) and self-defined care requirements (BB) were self-rated by patients with different tumor types before radiotherapy. Medical and sociodemographic data were also documented. We investigated 446 patients (262 male, 184 female; median age 60.0 years) with different diagnoses. Results: Stress was observed mainly due to reduction of efficiency, anxiety and pain on the subscales. Women had a significant higher stress on subscales of pain (p=0.016) and anxiety (p=0.009), patients younger than 45 years in the subscale information (p=0.002) and patients older than 45 and younger than 60 years in the subscale anxiety (p=0.002) and the total score (p=0.003). Patients with mamma carcinoma had the highest stress. The maximum percentages of patients under high stress were found for the subscales of efficiency (43%) and anxiety (40%). The support requirement was characterized by the need of more medical information and dialogue with the doctor. We saw a significant correlation of high stress and high care requirement. Conclusions: Psychosocial support should be founded on psychosocial stress diagnostic and self-defined care

  3. The beginning of a seed: regulatory mechanisms of double fertilization. (United States)

    Bleckmann, Andrea; Alter, Svenja; Dresselhaus, Thomas


    THE LAUNCH OF SEED DEVELOPMENT IN FLOWERING PLANTS (ANGIOSPERMS) IS INITIATED BY THE PROCESS OF DOUBLE FERTILIZATION: two male gametes (sperm cells) fuse with two female gametes (egg and central cell) to form the precursor cells of the two major seed components, the embryo and endosperm, respectively. The immobile sperm cells are delivered by the pollen tube toward the ovule harboring the female gametophyte by species-specific pollen tube guidance and attraction mechanisms. After pollen tube burst inside the female gametophyte, the two sperm cells fuse with the egg and central cell initiating seed development. The fertilized central cell forms the endosperm while the fertilized egg cell, the zygote, will form the actual embryo and suspensor. The latter structure connects the embryo with the sporophytic maternal tissues of the developing seed. The underlying mechanisms of double fertilization are tightly regulated to ensure delivery of functional sperm cells and the formation of both, a functional zygote and endosperm. In this review we will discuss the current state of knowledge about the processes of directed pollen tube growth and its communication with the synergid cells resulting in pollen tube burst, the interaction of the four gametes leading to cell fusion and finally discuss mechanisms how flowering plants prevent multiple sperm cell entry (polyspermy) to maximize their reproductive success.

  4. The beginning of a seed: regulatory mechanisms of double fertilization

    Directory of Open Access Journals (Sweden)

    Andrea eBleckmann


    Full Text Available The launch of seed development in flowering plants (angiosperms is initiated by the process of double fertilization: two male gametes (sperm cells fuse with two female gametes (egg and central cell to form the precursor cells of the two major seed components, the embryo and endosperm, respectively. The immobile sperm cells are delivered by the pollen tube towards the ovule harboring the female gametophyte by species-specific pollen tube guidance and attraction mechanisms. After pollen tube burst inside the female gametophyte, the two sperm cells fuse with the egg and central cell initiating seed development. The fertilized central cell forms the endosperm while the fertilized egg cell, the zygote, will form the actual embryo and suspensor. The latter structure connects the embryo with the sporophytic maternal tissues of the developing seed. The underlying mechanisms of double fertilization are tightly regulated to ensure delivery of functional sperm cells and the formation of both, a functional zygote and endosperm. In this review we will discuss the current state of knowledge about the processes of directed pollen tube growth and its communication with the synergid cells resulting in pollen tube burst, the interaction of the four gametes leading to cell fusion and finally discuss mechanisms how flowering plants prevent multiple sperm cell entry (polyspermy to maximize their reproductive success.

  5. Practical Life: The Keystone of Life, Culture, and Community (United States)

    Ramani, Uma


    Uma Ramani's characterization of practical life is philosophical and anthropological, suggesting that "human history is the story of the evolution of our practical life activities." Practical life is a collaborative activity that creates community and culture. One's adaptation to life through the daily work of ordering our environment…

  6. Direct losses of birds to pesticides - beginnings of a quantification (United States)

    Pierre Mineau


    Recent analyses and modeling of avian pesticide field studies have led to the conclusion that bird kills are regular and frequent in insecticide-treated fields. Unfortunately, data are seldom adequate to quantify this mortality. Also, mortality is expected to be highly variable in response to varying bird presence in and around treated fields. Studies reporting kills...

  7. The Application of Human Rights Law to Everyday Life under Rebel Control

    NARCIS (Netherlands)

    Fortin, K.M.A.


    This article draws upon social science literature to offer a new assessment of the normative value of human rights law vis-à-vis international humanitarian law in territory under armed groups’ control. In particular, the article considers how the two bodies of law can be applied in a complementary

  8. The Influence of Time Management Practices on Job Stress Level among Beginning Secondary Agriculture Teachers (United States)

    Lambert, Misty D.; Torres, Robert M.; Tummons, John D.


    Monitoring the stress of teachers continues to be important--particularly stress levels of beginning agriculture teachers. The study sought to describe the relationship between beginning teachers' perceived ability to manage their time and their level of stress. The Time Management Practices Inventory and the Job Stress Survey were used to measure…

  9. Entering the Field: Beginning Teachers' Positioning Experiences of the Staffroom (United States)

    Christensen, Erin; Rossi, Tony; lisahunter; Tinning, Richard


    Little is known about beginning teachers' political positioning experiences of the staffroom. This paper employs Bourdieu's conceptual tools of field, habitus and capital to explore beginning health and physical education teachers' positioning experiences and learning in staffrooms, the place in which teachers spend the majority of their…

  10. Professional Learning Places and Spaces: The Staffroom as a Site of Beginning Teacher Induction and Transition (United States)

    lisahunter; Rossi, Tony; Tinning, Richard; Flanagan, Erin; Macdonald, Doune


    This paper argues that the staffroom is an important professional learning space where beginning teachers interact to understand who they are and the nature of their professional work. The authors highlight the theoretical importance of space and place in the construction and negotiation of beginning teacher subjectivities. To illustrate the…

  11. Canton and Nagasaki compared, the beginning and the end of Dutch, Chinese and Japanese relations

    NARCIS (Netherlands)

    Poel, van der R.H.M.


    Article on the 2nd international conference on 'Canton and Nagasaki compared', examining the beginning and the end of Dutch, Chinese and Japanese relations, 29 November-4 December 2009. Impression of all given papers clustered round ten central themes as - The beginning of the system - Gvernment and

  12. Sex differences in the hypothalamus in the different stages of human life

    NARCIS (Netherlands)

    Swaab, Dick F.; Chung, Wilson C. J.; Kruijver, Frank P. M.; Hofman, Michel A.; Hestiantoro, Andon


    Quite a number of structural and functional sex differences have been reported in the human hypothalamus and adjacent structures that may be related to not only reproduction, sexual orientation and gender identity, but also to the often pronounced sex differences in prevalence of psychiatric and

  13. The influence of video recordings on beginning therapists’ learning in psychotherapy training

    DEFF Research Database (Denmark)

    Jacobsen, Claus Haugaard; Olesen, Mette Kirk; Kløve, Astrid

    a qualitative, explorative study of the influence video recordings have on the beginning therapist and his/her evolving learning process in becoming a psychotherapist. Methods: 24 beginning therapists in training at an outpatient university clinic setting filled out a questionnaire containing ten open...... the current relatively widespread use of video, one finds only a very limited number of empirical studies on how these recordings specifically influence the learning process of the beginning therapist. Aim: After a brief discussion of the pro and cons of the use of video recordings this paper presents...... is that video recordings facilitate the learning experience of the beginning therapist. They report how video helped them gaining an overall deeper understanding of psychotherapy and themselves as therapists. At the beginning they felt anxious and exposed but it decreased over time and became a learning...

  14. The influence of video recordings on beginning therapist’s learning in psychotherapy training

    DEFF Research Database (Denmark)

    Jacobsen, Claus Haugaard; Olesen, Mette Kirk; Kløve, Astrid


    a qualitative, explorative study of the influence video recordings have on the beginning therapist and his/her evolving learning process in becoming a psychotherapist. Methods: 24 beginning therapists in training at an outpatient university clinic setting filled out a questionnaire containing ten open...... the current relatively widespread use of video, one finds only a very limited number of empirical studies on how these recordings specifically influence the learning process of the beginning therapist. Aim: After a brief discussion of the pro and cons of the use of video recordings this paper presents...... is that video recordings facilitate the learning experience of the beginning therapist. They report how video helped them gaining an overall deeper understanding of psychotherapy and themselves as therapists. At the beginning they felt anxious and exposed but it decreased over time and became a learning...

  15. Beginning teachers' self-efficacy and stress and the supposed effects of induction arrangements

    NARCIS (Netherlands)

    Helms-Lorenz, Michelle; Slof, Bert; Vermue, Carlien E.; Canrinus, Esther. T.


    Induction arrangements are implemented in schools all over the world to support beginning teachers (BTs) (novices) in gradually growing into their profession. The aim of this study is to gain more insight into two key psychological processes involved in the work of a qualified beginning teacher,

  16. Beginning Teachers' Self-Efficacy and Stress and the Supposed Effects of Induction Arrangements (United States)

    Helms-Lorenz, Michelle; Slof, Bert; Vermue, Carlien E.; Canrinus, Esther T.


    Induction arrangements are implemented in schools all over the world to support beginning teachers (BTs) (novices) in gradually growing into their profession. The aim of this study is to gain more insight into two key psychological processes involved in the work of a qualified beginning teacher, namely perceived stress and self-efficacy. This…

  17. Laboratory Practices of Beginning Secondary Science Teachers: A Five-Year Study (United States)

    Wong, Sissy S.; Firestone, Jonah B.; Luft, Julie A.; Weeks, Charles B.


    During the beginning years of teaching, science teachers develop the knowledge and skills needed to design and implement science laboratories. In this regard, this quantitative study focused on the reported laboratory practices of 61 beginning secondary science teachers who participated in four different induction programs. The results…

  18. What Are the Effects of Induction and Mentoring on Beginning Teacher Turnover? (United States)

    Smith, Thomas M.; Ingersoll, Richard M.


    In recent years there has been an increase in the number of programs offering support, guidance, and orientation for beginning teachers during the transition into their first teaching job. This study examines whether such programs--collectively known as induction--have a positive effect on the retention of beginning teachers. The data used in the…

  19. 78 FR 4868 - Notice of Deadline for Submitting Completed Applications To Begin Participation in the Tribal... (United States)


    ... Bureau of Indian Affairs Notice of Deadline for Submitting Completed Applications To Begin Participation... completed applications to begin participation in the tribal self-governance program in fiscal year 2014 or... 355-G-SIB, 1951 Constitution Avenue NW., Washington, DC 20240. FOR FURTHER INFORMATION CONTACT: Dr...

  20. 76 FR 5395 - Notice of Deadline for Submitting Completed Applications To Begin Participation in the Tribal... (United States)


    ... Bureau of Indian Affairs Notice of Deadline for Submitting Completed Applications To Begin Participation... completed applications to begin participation in the tribal self-governance program in fiscal year 2012 or... 355-G-SIB, 1951 Constitution Avenue, NW., Washington, DC 20240. FOR FURTHER INFORMATION CONTACT: Dr...

  1. Environmental and human health assessment of life cycle of nanoTiO2 functionalized porcelain stoneware tile. (United States)

    Pini, Martina; Bondioli, Federica; Montecchi, Rita; Neri, Paolo; Ferrari, Anna Maria


    Recently, there has been a rise in the interest in nanotechnology due to its enormous potential for the development of new products and applications with higher performance and new functionalities. However, while nanotechnology might revolutionize a number of industrial and consumer sectors, there are uncertainties and knowledge gaps regarding toxicological effects of this emerging science. The goal of this research concerns the implementation into Life Cycle Assessment (LCA) of preliminary frameworks developed to evaluate human toxicity and exposure factors related to the potential nanoparticle releases that could occur during the life cycle steps of a functionalized building material. The present LCA case study examines the ecodesign of nanoTiO 2 functionalized porcelain stoneware tile production. The aim of this investigation is to manufacture new eco-friendly products in order to protect human health and ecosystem quality and to offer the market, materials with higher technological properties obtained by the addition of specific nanomaterials. Copyright © 2016 Elsevier B.V. All rights reserved.

  2. Home-based telecommuting and quality of life: further evidence on an employee-oriented human resource practice. (United States)

    Hornung, Severin; Glaser, Jürgen


    Building on previous research, further evidence for the potential of home-based telecommuting as an employee-oriented human resource practice is provided from a study in the German public administration. Survey data from 1,008 public employees were analyzed using structural equation modeling. Mean age of the sample was 43.6 yr. (SD = 8.8 yr.), and 27.5% (277) of the participants were women. Analysis supported the roles of higher Autonomy and lower Work-Family Conflict as psychological mediators between Telecommunication Intensity and both Job Satisfaction and Quality of Life. Implications for the design of flexible working arrangements are discussed.

  3. Aesthetics of the Human Image in Life and Iconography of the Ancient Philosophers in Art

    Directory of Open Access Journals (Sweden)

    Dorofeev, Daniil


    Full Text Available The acoustic and visual understanding of man is a hotly debated issue in contemporary culture. I found it important therefore to look at certain historical, cultural, aesthetical, philosophical and anthropological peculiarities of human image in Antiquity as reflected in the arts. The following aspects deserve special attention: the visualization of sense and values; the interaction of “ethos” (character and “soma” (body; the influence of the plastic images on the narrative ones; a normative typology of man; the significance of visual and acoustic perception. In this context, I studied ancient physiognomic; Aristotelian understanding of the acoustic and plastic arts; genesis, evolution and significance of the sculptural portrait image of man and the image of philosopher in Antiquity. I also pay attention to some methodological aspects of the study. As a result, there emerges an integral image of philosopher, which allows looking at the Greek culture from a fresh angle.

  4. A Model for Online Support in Classroom Management: Perceptions of Beginning Teachers (United States)

    Baker, Credence; Gentry, James; Larmer, William


    Classroom management is a challenge for beginning teachers. To address this challenge, a model to provide support for beginning teachers was developed, consisting of a one-day workshop on classroom management, followed with online support extending over eight weeks. Specific classroom management strategies included (a) developing a foundation…

  5. The Importance of the Beginning Teachers' Psychological Contract: A Pathway toward Flourishing in Schools (United States)

    Dollansky, Tracy D.


    Beginning teachers enter the profession with notions about what their school organization will provide for them and what they will give their organization, in exchange. Psychological contracts, as defined by Schein exist between beginning teachers and their organization. I contend, with the use of a conceptual framework, that if the implicit terms…

  6. Integrating the teaching role into one's identity : a qualitative study of beginning undergraduate medical teachers

    NARCIS (Netherlands)

    Van, Lankveld T.; Schoonenboom, J.; Kusurkar, R.A.; Volman, M.; Beishuizen, J.; Croiset, G.


    Beginning medical teachers often see themselves as doctors or researchers rather than as teachers. Using both figured worlds theory and dialogical self theory, this study explores how beginning teachers in the field of undergraduate medical education integrate the teacher role into their identity. A

  7. [Beginning of the Microbiology education in Chile: formation centers]. (United States)

    Osorio, Carlos


    The first Chair of Microbiology in Chile was created in the School of Medicine of the Cañadilla at the University of Chile in 1892. Dr. Alejandro del Río Soto Aguilar was its first Professor. For almost three decades it was the only educational center for microbiologists in Chile. Among them were the first Professors of the new School of Medicine of the Catholic University of Chile and of the University of Concepción.

  8. Remarks on the ''beginning'' and the ''end'' of the universe

    International Nuclear Information System (INIS)

    Deppert, W.


    The concept of time is discussed. If time is defined with physical objects, one is led to the contradiction of eternity with finite duration. It is possible to avoid this contradiction by the introduction of different types of time. The concepts of superspace and ''many-fingered time'' are expressions for the variety of times, and not for the breakdown of the concept of time. With the aid of the distinctions of different well-defined notions of time, knowledge about the time-dependent laws of Nature increases

  9. Child labour, human capital and life expectancy


    Giam Pietro Cipriani


    This paper studies new mechanisms through which human capital and longevity interact with child labour and endogenous fertility. When children provide old age support in the form of care and companionship, the economy may display multiple development regimes: a development trap with low human capital and large use of child labour or a high steady state with high longevity and human capital and low child labour. A situation with indeterminacy of equilibrium outcomes may also occur if child mor...

  10. The beginning of African biblical interpretation: The bible among the ...

    African Journals Online (AJOL)

    Prior to the translation of the Bible in Africa, Africans were already engaging with the Bible, initially as an iconic object of power and then as an aural object. In the first section of this article I attempt to detect elements of the early reception of the Bible among the BaTlhaping people. The second section of the article then ...

  11. Tacit Beginnings towards a Model of Scientific Thinking (United States)

    Glass, Rory J.


    The purpose of this paper is to provide an examination of the role tacit knowledge plays in understanding, and to provide a model to make such knowledge identifiable. To do this I first consider the needs of society, the ubiquity of information in our world and the future demands of the science classroom. I propose the use of more implicit or…




  13. Joint assessment of specific sites for ITER begins at Clarington

    International Nuclear Information System (INIS)

    Stewart, M.J.


    Clarington, Ontario, Canada was the subject of the first official stage of the Joint Assessment of Specific Sites (JASS) for the ITER Project. The Assessment is part of the Negotiations process and is being conducted by an ad-hoc group of the Negotiators with representatives from Canada, the European Union, Japan and Russian Federation, supported by the ITER international team. The evaluation was conducted over four days through a series of visits to the site itself, a review of materials included in Canada's submission to host ITER, presentations from group leading Canada's offer and experts on specific aspects of the offer

  14. An unexpected beginning of year on the international petroleum market

    International Nuclear Information System (INIS)

    Nachet, S.


    The petroleum market seems to enter a durable easing phase in 1998. Most of price projections are between 16 and 18 U.S. Dollar per barrel of Brent, which represents a 1 to 2 U.S. Dollar reduction with respect to the same projections realized in December 1997. This paper analyzes the reasons of this situation and the possible duration of their effects: increase of the OPEC's production quotas in the end of November, the renewal of the resolution 986 of the United Nations concerning Iraq exports, and a mild winter and the Asian crisis which reduces the worldwide demand. (J.S.)

  15. The performance of modern education in the context of human adaptation to life in the new conditions of civilization

    Directory of Open Access Journals (Sweden)

    Sergei K. Kostyuchkov


    Full Text Available The article deals with approaches to performance analysis of modern education in the context of the third millennium civilization conditions; analyzes the trends of modern social development through their awareness in the context of philosophy of education essence; author focuses attention on the concept of «education» as a mechanism of adaptation of the individual to life, the instrument of transmission of cultural values, social norms and sensozhyttyevyh plants; put forward a reasoned statement that modern education, despite many theories, trends, patterns, traditionally focused on humanism does not have sufficient human resource for the future and the survival of mankind civilization in the new conditions. It is emphasized that modern education shall be directed to the individual adaptation to life and new civilizations conditions and socially significant accumulation of personal knowledge. The author notes that in modern education, a new type of scientific rationality; humanistic dimension of modern education due and specific information society and the content of a new look at svitooblashtuvannya, determined the need to address global problems. The article emphasizes the urgency provisions against which long-term sustainable development based on the laws of nature must become the dominant purpose around the world, requiring perceive and understand the education system as a producer of social vanguard, whose members have the knowledge to master such a system through which an educated man will be able not only to understand the complexity of processes and phenomena of the surrounding world, to explain them, but also constructively influence to this world.

  16. China at the beginning of 3rd millennium: geopolitical perspectives

    Directory of Open Access Journals (Sweden)

    Florin Pintescu


    Full Text Available The paper presents and briefly examines the main geohistorical, geoeconomic and geostrategic advantages of China, related to this attempt to become a regional hegemonic power and, in special circumstances, a worldwide superpower. First, is presented a historical background of the country, a source of self-confidence and rise of the so-called “Chinese mentality”, different of Western mentality. Further is shown the essence of the Chinese contemporary naval strategy (Haijun Zhanlue, currently an essential element of geostrategy of this country. Policies and economic resources of the country – the fundamental elements of its geopolitics – are more detailed presented. The final part of the article reviews and analyzes the advantages and disadvantages of strategic policy towards Central Asia and China’s fundamental goal – gaining of the regional hegemonic power status.In conclusion, the authors consider that in order to become the first superpower of the world in the next 2-3 decades, China needs a mixture of brilliant leadership, economic growth, modernization (not Westernization!, Chinese mentality and “Chinese way of life” (last two based on Tao. If a single element of this combination will not work properly, this “Chinese dream” will not be achieved.

  17. Exploration Life Support Critical Questions for Future Human Space Missions (United States)

    Kwert, Michael K.; Barta, Daniel J.; McQuillan, Jeff


    Exploration Life Support (ELS) is a current project under NASA's Exploration Systems Mission Directorate. The ELS Project plans, coordinates and implements the development of advanced life support technologies for human exploration missions in space. Recent work has focused on closed loop atmosphere and water systems for long duration missions, including habitats and pressurized rovers. But, what are the critical questions facing life support system developers for these and other future human missions? This paper explores those questions and how progress in the development of ELS technologies can help answer them. The ELS Project includes the following Elements: Atmosphere Revitalization Systems, Water Recovery Systems, Waste Management Systems, Habitation Engineering, Systems Integration, Modeling and Analysis, and Validation and Testing, which includes the Sub-Elements Flight Experiments and Integrated Testing. Systems engineering analysis by ELS seeks to optimize overall mission architectures by considering all the internal and external interfaces of the life support system and the potential for reduction or reuse of commodities. In particular, various sources and sinks of water and oxygen are considered along with the implications on loop closure and the resulting launch mass requirements. Systems analysis will be validated through the data gathered from integrated testing, which will demonstrate the interfaces of a closed loop life support system. By applying a systematic process for defining, sorting and answering critical life support questions, the ELS project is preparing for a variety of future human space missions

  18. Nothing Begins with N: New Investigations of Freewriting. (United States)

    Belanoff, Pat, Ed.; And Others

    This book provides a theoretical underpinning for the strategy of freewriting through a collection of 16 essays that are very diverse in focus, methodology, and point of view. The essays are as follows: "Recording and Transforming: The Mystery of the Ten-Minute Freewrite" (Sheryl I. Fontaine); "Freewriting: An Aid to Rereading…

  19. Spongelike Acquisition of Sight Vocabulary in Beginning Readers? (United States)

    Stuart, Morag; Masterson, Jackie; Dixon, Maureen


    Investigates the relation between phonological awareness, sound-to-letter mapping knowledge, and printed word learning in novice five-year-old readers. Explores effects of visual memory and of teaching methods. Finds mental representations of printed words are more easily formed by beginners who are able to match at least some of the phonological…

  20. The Beginnings of Resilience: A View Across Cultures (United States)

    Ungar, Michael


    A close read of studies of children's development says that remarkably large numbers of children mature successfully despite exposure to poverty, war, violence, family dislocation, cultural genocide, sexual abuse, physical injury, mental illness, loss of a parent, loneliness, hunger, neglect and the numerous other crimes one commits against…

  1. Componential Skills of Beginning Writing: An Exploratory Study (United States)

    Kim, Young-Suk; Al Otaiba, Stephanie; Puranik, Cynthia; Folsom, Jessica Sidler; Greulich, Luana; Wagner, Richard K.


    The present study examined the components of end of kindergarten writing, using data from 242 kindergartners. Specifically of interest was the importance of spelling, letter writing fluency, reading, and word- and syntax-level oral language skills in writing. The results from structural equation modeling revealed that oral language, spelling, and…

  2. Counterexamples from elementary calculus to the beginnings of analysis

    CERN Document Server

    Bourchtein, Andrei


    IntroductionCommentsOn the structure of this bookOn mathematical language and notationBackground (elements of theory)SetsFunctionsFUNCTIONS OF ONE REAL VARIABLEElementary properties of functionsElements of theoryFunction definitionBoundednessPeriodicityEven/odd functionsMonotonicityExtremaExercisesLimitsElements of theoryConceptsElementary properties (arithmetic and comparative)ExercisesContinuityElements of theoryLocal propertiesGlobal properties: general resultsGlobal properties: the famous theorems Mapping setsWeierstrass theoremsIntermediate Value theoremUniform continuityExercisesDifferentiationElements of theoryConceptsLocal propertiesGlobal propertiesApplicationsTangent lineMonotonicity and local extremaConvexity and inflectionAsymptotesL'Hospital's ruleExercisesIntegralsElements of theoryIndefinite integralDefinite (Riemann) integralImproper integralsApplicationsExercisesSequences and seriesElements of theoryNumerical sequencesNumerical series: convergence and elementary propertiesNumerical series: co...

  3. Complex numbers, quantum mechanics and the beginning of time

    International Nuclear Information System (INIS)

    Gibbons, G.W.; Pohle, H.J.


    A basic problem in quantizing a field in curved space is the decomposition of the classical modes in positive and negative frequency. The decomposition is equivalent to a choice of a complex structure in the space of classical solutions. In our construction the real tunneling geometries provide the link between this complex structure and analytic properties of the classical solutions in a riemannian section of space. This is related to the Osterwalder-Schrader approach to euclidean field theory. (orig.)

  4. [Foundational questions in the beginning of clinical psychology]. (United States)

    Ceccarelli, Glauco


    This work proposes an initial survey on the origins of American clinical psychology between the nineteenth and twentieth century, against a backdrop of historiographical interpretation that hypothesizes a "plurality of matrices" of clinical psychology, linked to different theoretical perspectives and different socio-cultural contexts. Particular attention is focused upon the main foundational issues of the discipline, drawing from some of the writings of Lightner Witmer, to whom we owe the founding of the first "clinical psychology" for subjects in childhood characterized by "retardation or physical defects interfering with school progress"; and of a lesser-known scholar, John E.W. Wallin. Both authors, indeed, worry themselves anxious to define clinical psychology, differentiating it from other medical and psychological branches; to establish which is the field of competence of the clinical psychologist; and to outline their training and specify the aims and contents of their intervention. Attention is then addressed to the relationship psychologists-psychiatrists at the time of its emergence, making specific reference to a document of the New York Psychiatrical Society--which represents one of the first attempts to exclude clinical psychologists from the field of mental health--and reporting also on the response to this position signed by Shepherd Franz. After an allusion to the Italian situation from the 1950s to today, the article concludes by emphasizing that at least some of the basic questions that clinical psychology had to deal with at its birth are still present, though filtered through the intense debate that has taken place over the years, and consequently supporting the importance of a historical component in the training of contemporary clinical psychologists.

  5. The electrification of the world begins at Labastide-Murat

    International Nuclear Information System (INIS)

    Matly, M.


    There is a basic historical contradiction in France being the leader in public electrification while at the same time the French state has never assumed the associated financial or business risks. The electrification of the country has been built virtually entirely around decentralized initiatives and the national company has only completed, modernized and managed the existing system though doubtless with a great deal of professionalism and success. It is probably this very professionalism and success which have given electrical producers an the Third World, (seeking a role model in the developed world), a false image of the future of this sector, presenting it as that of a large company moving from the centre outwards, from the town to the rural world. Beyond the ideologies of public versus private which have left their mark on the history of electricity for several decades, the French experience gives the image of an electrification programme which is being built up by the will of the people, where a centralized and highly legislative State has succeeded in both stimulating a large number of private entrepreneurs, large and small alike, and mobilizing tens of thousands of districts sharing this ambition, as shown by the example of Labastide Murat, a small village in the South West of France. (author)

  6. The beginnings of the written culture in Antiquity

    Directory of Open Access Journals (Sweden)

    M. Isabel Panosa


    Full Text Available This paper proposes an analysis of writing as a system for communication, since its origins, in terms of its uses and socio-cultural context. We shall also look to review and comment on the way in which it has evolved in time and space and its primordial domains for expression. Likewise, we shall look at the current state of affairs with respect to graphic communication, which includes the alphabet, logographic systems and symbols. From a more global point of view, the relationship between the concept of writing and the concept of civilisation is studied and two dimensions are set out: the oral culture and the written culture.

  7. Tacit Beginnings Towards a Model of Scientific Thinking (United States)

    Glass, Rory J.


    The purpose of this paper is to provide an examination of the role tacit knowledge plays in understanding, and to provide a model to make such knowledge identifiable. To do this I first consider the needs of society, the ubiquity of information in our world and the future demands of the science classroom. I propose the use of more implicit or tacit understandings as foundational elements for the development of student knowledge. To justify this proposition I consider a wide range of philosophical and psychological perspectives on knowledge. Then develop a Model of Scientific Knowledge, based in large part on a similar model created by Paul Ernest (Social constructivism as a philosophy of mathematics, SUNY Press, Albany, NY, 1998a; Situated cognition and the learning of mathematics, University of Oxford Department of Educational Studies, Oxford, 1998b). Finally, I consider the work that has been done by those in fields beyond education and the ways in which tacit knowledge can be used as a starting point for knowledge building.


    Indian Academy of Sciences (India)


  9. Componential skills of beginning writing: An exploratory study


    Kim, Young-Suk; Al Otaiba, Stephanie; Puranik, Cynthia; Folsom, Jessica Sidler; Greulich, Luana; Wagner, Richard K.


    The present study examined the components of end of kindergarten writing, using data from 242 kindergartners. Specifically of interest was the importance of spelling, letter writing fluency, reading, and word- and syntax-level oral language skills in writing. The results from structural equation modeling revealed that oral language, spelling, and letter writing fluency were positively and uniquely related to writing skill after accounting for reading skills. Reading skill was not uniquely rel...

  10. Hilbert's Nullstellensatz and the Beginning of Algebraic Geometry

    Indian Academy of Sciences (India)

    yeS) := {(aI, .. , an) E R n. : fi(al, .. , an) = 0 for all i E S}. That is, yeS) is the set of common zeroes (or zero locus) of all the polynomials in S. For brevity, it is often just called a real algebraic set. Similarly one can define a complex algebraic set as the common zero-set in en of some collection S of polynomials in n variables Xl, ...

  11. The beginning of time observed in quantum jumps

    Energy Technology Data Exchange (ETDEWEB)

    Bohm, Arno [CCQS, Physics Department, University of Texas, Austin, TX (United States); Bryant, Peter W. [IBM Research, Rio de Janeiro (Brazil); Uncu, Haydar [Department of Physics, Adnan Menderes University, Aydin (Turkey); Wickramasekara, Sujeev [Department of Physics, Grinnell College, Grinnell, IA (United States); Schleich, Wolfgang P. [Institut fuer Quantenphysik and Center for Integrated Quantum Science and Technology, Universitaet Ulm (Germany); Hagler Institute for Advanced Study, Texas A and M University, College Station, TX (United States); Texas A and M AgriLife, Institute for Quantum Science and Engineering (IQSE) and Department of Physics and Astronomy, Texas A and M University, College Station, TX (United States)


    The phenomenon of quantum jumps observed in a single ion stored in a trap brings to light intimate connections between three different concepts of quantum physics: (i) quantum state trajectories, (ii) Gamow states, and (iii) the arrow of time. In particular, it allows us to identify the starting time of the semigroup time evolution. (copyright 2017 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  12. Croatian Migration at the Beginning of the 21st Century

    Directory of Open Access Journals (Sweden)

    Ivan Lajić


    Full Text Available Throughout the most recent time-period, all modalities of migration have existed, side-by-side, in Croatia, hence confirming a high degree of mobility of its population, and also indicating a wide range of factors causing migration. The scale of Croatian migration, the spatial distribution of the various sending areas, the demographic structure of the migrant contingent, and especially the negative migration balance on the national level, as well as on the level of the country’s main regions, are all indications of a negative effect on socio-economic and especially demographic development. At the same time, some forms of migration that have previously dominated – e.g. economic migration to the countries of Western Europe, seasonal internal migration and circulation of labour, rural-urban migration – are by now becoming phenomena of second-rate importance. Nevertheless, in the present migration constellation, migration still has a negative effect on the demographic development of Croatia. The internal demographic polarisation within Croatia, characterised by propulsive areas on the one hand, and an ever broader depopulational pole on the other, is increasing in relevance, since the vitality of demographic events (natural growth and a positive migration balance is tied to large cities, which brings about a further problem, i.e. an asimetrical spatial development caused by the growing oligocentric significance of regional centres. The author estimates that natural growth of Croatia’s population in the inter-census period from 1991 to 2001 amounted to 45,000. If only that component would be taken into account, Croatia’s population should have fallen from 4,784,265 to 4,739,265. The population, however, fell to 4,437,460. Therefore, on the basis of such (in fact discrepant criteria, 301,805 more persons left Croatia, than arrived through immigration in the same time-period. Two basic categories that have contributed to this loss are

  13. Since the beginning of the century, the country has undertaken ...

    African Journals Online (AJOL)


    Today, fish farming represents the fastest growing sector of food production. Moreover, aquaculture has a major role to play in the achievement of the first three Sustainable .... economic viability of shrimp farming in the coastal zone. .... although standards have been set for feed production and certification, enforcement has.

  14. The Beginnings of Communication Study in the United States. (United States)

    Schramm, Wilbur

    The history of communication research in the United States is reviewed in this paper through an extensive look at the lives of four men who made significant contributions to the field: Harold Lasswell, Kurt Lewin, Paul Lazarsfeld, and Carl Hovland. The pattern of institute formation in the social sciences is briefly reviewed to explain the…

  15. Lexical Orthographic Knowledge Develops from the Beginning of Literacy Acquisition (United States)

    Martinet, Catherine; Valdois, Sylviane; Fayol, Michel


    This study reports two experiments assessing the spelling performance of French first graders after 3 months and after 9 months of literacy instruction. The participants were asked to spell high and low frequency irregular words (Experiment 1) and pseudowords, some of which had lexical neighbours (Experiment 2). The lexical database which children…

  16. The Matthean community according to the beginning of his gospel ...

    African Journals Online (AJOL)

    The social setting of the Gospel according to Matthew remains a much debated issue. The theory of a gentile setting with historical roots within Judaism was met with much opposition in recent times. The expression “the parting of the ways” as introduced by Dunn and popularised by Stanton effectively marks this discussion.

  17. The international year of pulses was just the beginning | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)


    Jan 17, 2017 ... Addressing barriers to pulse consumption through the development of new pulse varieties, production methods and food products is key to tapping into the full ... a public-private initiative of pre-cooked beans, an affordable and fast-cooking new product which is boosting the consumption of nutritious pulses.

  18. "Educational Theory" in the Fifties: The Beginning of a Conversation. (United States)

    Feinberg, Walter; Odeshoo, Jason


    Examines writing on educational theory in the 1950s, a time of presumed consensus, where essentialisms were taken for granted and homeostasis and homogeneity were held up as social aims, noting that the surface civility of the field hid underlying exclusions and tensions and that questions were not being asked about the lack of attention to…

  19. Nuclear PDFs in the beginning of the LHC era

    Energy Technology Data Exchange (ETDEWEB)

    Paukkunen, Hannu, E-mail: [Department of Physics, University of Jyväskylä, P.O. Box 35, FI-40014 (Finland); Helsinki Institute of Physics, University of Helsinki, P.O. Box 64, FI-00014 (Finland)


    The status of the global fits of nuclear parton distributions (nPDFs) is reviewed. In addition to comparing the contemporary analyses of nPDFs, difficulties and controversies posed by the neutrino–nucleus deeply inelastic scattering data is overviewed. At the end, the first dijet data from the LHC proton+lead collisions are briefly discussed.

  20. Pathology Gross Photography: The Beginning of Digital Pathology. (United States)

    Rampy, B Alan; Glassy, Eric F


    The underutilized practice of photographing anatomic pathology specimens from surgical pathology and autopsies is an invaluable benefit to patients, clinicians, pathologists, and students. Photographic documentation of clinical specimens is essential for the effective practice of pathology. When considering what specimens to photograph, all grossly evident pathology, absent yet expected pathologic features, and gross-only specimens should be thoroughly documented. Specimen preparation prior to photography includes proper lighting and background, wiping surfaces of blood, removing material such as tubes or bandages, orienting the specimen in a logical fashion, framing the specimen to fill the screen, positioning of probes, and using the right-sized scale. Copyright © 2015 Elsevier Inc. All rights reserved.

  1. Nurse leaders as stewards: the beginning of change. (United States)

    Murphy, Norma Sinnott


    In understanding fully persons' moral predicaments, a core component of forming perceptual judgments, nurses may need to shift the epistemology of their practice from instrumental reasoning, or means-ends thinking, integrating a virtue-based practical reasoning. A bearing witness that achieves understanding of clients' moral qualities is attained through the articulation of nurses' self-identities within matrices, such as MacIntyre's theory of virtue ethics and standards and codes of ethics. Moreover, nurse leaders who exercise stewardship could apply the concept of communities of inquiry to structure learning conditions by which nurses may engage in experiential learning. This leadership enhanced by the nurse steward's phronetic knowledge, or practical wisdom, which guides understanding of how the clockwork of practical reasoning may evolve within such communities, is critical to nurses' shift in reasoning. Nonetheless, nurse leaders need empirical evidence to comprehend how stewards' accumulated moral insights may shape their character qualities, hence selection of values upon which to act in facilitating nurses' self-expression.

  2. Solar neutrino physics on the beginning of 2017

    International Nuclear Information System (INIS)

    Vissani Francesko


    This writeup is a review of current hot topics on solar neutrinos. It is based on a talk at the conference ''Neutrinos: the quest for a new physics scale'', held at the CERN on March 2017, where the Organizers entrusted me with a discussion of the provocative question ''whether solar neutrino physics is over''. Rather than providing a straight (negative) answer, in view of an audience consisting mostly of colleagues working in theoretical particle physics, I deemed it more useful providing a description of what is the current activity of the physicists working in solar neutrinos, leaving the listener free of forming his/her own opinion apropos.

  3. Minimalism as civilization paradigmat the beginning of the 21. century

    Directory of Open Access Journals (Sweden)

    Vasilski Dragana


    Full Text Available The term minimalism is currently used descriptively to refer to a style marked by a certain asceticism in the art, architecture and design. It has begun from American Minimal Art of the 1960s in the fields of painting and sculpture and has filtered into other sectors of society. It is now found in fashion, music, literature and interior decoration, as well as architecture. Minimalisms has come to define the result of the use of simple geometric forms, pure and simple lines, the modular principle, surfaces with a smooth industrial appearance that negate any character of handmade individuality. As far as architecture is concerned, minimalism is characterized by the emphasis on essential elements - like light and the way it falls on the volumes and masses that make up buildings and shape space and structure. Linear structures and essential geometric forms define identity but despite the apparent simplicity of these works the effect they make is extremely complex.

  4. John Ambrose Fleming and the Beginning of Electronics

    Energy Technology Data Exchange (ETDEWEB)

    Fred Dylla; Steve Corneliussen


    2004 was the centenary of John Ambrose Fleming's momentous patent on the thermionic diode that can be called the birth of electronics. The ''Edison effect'' was discovered in 1882; this was later shown to be the result of thermionic emission of electrons from a heated filament into a vacuum. Edison did not make any significant devices based on this discovery, and the effect was ignored for more than 8 years. In 1890 Fleming explained the effect and showed that the thermionic diode could be used as a rectifier. Fourteen years later Fleming filed his 1904 patent on the thermionic diode. It was the first public announcement of the electron tube; this revolutionized the development of radio and led to the invention of the thermionic triode by Lee de Forest in 1906. The background to these events will be described.

  5. Marginalia as the beginning of written culture: The Glosas Emilianensis

    Directory of Open Access Journals (Sweden)

    Maja Šabec


    Full Text Available The Glosas emilianenses are notes in Latin and in a Romance language dating from the eleventh century, written by an anonymous monk between the lines and in the margins of a Latin manuscript known as Codex Aemilianensis 60 to explicate syntactic, morphological, and semantic difficulties in understanding the original. The document was named after its place of origin, a monastery in the village of San Millán de la Cogolla, known as “the cradle of Castilian.” The non-Latin Romance glosses are believed to be the first written accounts of the language that later evolved into present-day Castilian or Spanish; they are therefore invaluable historical, linguistic, literary, and cultural material. The place and time of the origin of the glosses are not a coincidence, but a consequence of particular historical circumstances in the Iberian Peninsula. The Moorish invasion in 711 AD destroyed the Visigothic Kingdom and constrained the development of Christian culture, confining it to two independent cores in the north. The ninth century therefore saw the establishment of the County of Castile emerging from the two cores as the predecessor of the Kingdom of Castile (1065. Due to turbulent historical events, the place was populated by people from various adjacent and rather distant countries, thus making the spoken language a mixture of several varieties of Vulgar Latin, Mozarabic, and Navarrian (Basque elements. All of these features are reflected in the glosses in the San Millán manuscript. Therefore, it is difficult for linguists to name the variant of the Romance language the glosses were written in: “the Riojan dialect,” “a vernacular Castilian-Riojan dialect of the second half of the eleventh century displaying tendencies towards learned Latin,” or “a Riojan dialect with elements more common to neighboring dialects (Aragon, Navarrian, Léon, and Mozarabic than to Castilian.” However, because the San Millán glosses also include elements

  6. Humble beginnings: Current trends, state perspectives, and hallmarks of humility


    Chancellor, J; Lyubomirsky, S


    After decades of neglect, research in humility is finally turning a corner. Within the past few years, investigators have articulated two promising strategies to overcome methodological concerns - namely, using personality judgments and designing humility "stress tests" to elicit humility-relevant behavior. We also highlight an alternative perspective of humility that has not yet gained much attention: the investigation of humility as a state, which helps to understand what humility actually ...

  7. The biopuces: the begining of a real medical revolution

    International Nuclear Information System (INIS)


    The biopuces of DNA analysis is an ambitious project. In ten years, the biopuces will be the main tools for medicine, especially in diagnosis. The DNA hybridization consists to combine DNA sequences of a sample with specific synthesized complementary DNA sequences, called DNA probes, which are easily detectable. It permits to have information about the presence of the selected DNA sequence in the Sample. On a biopuce, this operation is achieved by grafting the corresponding probes to a common support (F.M.)

  8. LHC Report: perhaps the end of the beginning

    CERN Multimedia

    Mike Lamont for the LHC team


    The 2015 6.5 TeV proton run will end on the morning of 4 November as we approach the close of an interesting but somewhat challenging year. Following machine development time and a technical stop, the LHC will restart operation with a proton-proton configuration at 2.51 TeV in the middle of November. Data from this special run will be used by the experiments as a reference point for the proton-lead and lead-lead collisions.     The rate of UFOs per hour has dropped since the first high-intensity runs. Here it is seen after the first scrubbing run (SR1), through the second technical stop (TS2) until now (right end of the abscissae). As of the end of October, the LHC is delivering luminosity in the order of 4.8x1033 cm-2s-1 to ATLAS and CMS, 3x1032 cm-2s-1 to LHCb and 5x1030 cm-2s-1 to ALICE, with an integrated luminosity of around 3.5 fb-1 for both ATLAS and CMS. Looking back, the year’s operations can be roughly divided into four main phases, interspersed with technica...

  9. Beyond the Cut Hunter: A Historical Epidemiology of HIV Beginnings in Central Africa. (United States)

    Rupp, Stephanie; Ambata, Philippe; Narat, Victor; Giles-Vernick, Tamara


    In the absence of direct evidence, an imagined "cut hunter" stands in for the index patient of pandemic HIV/AIDS. During the early years of colonial rule, this explanation goes, a hunter was cut or injured from hunting or butchering a chimpanzee infected with simian immunodeficiency virus, resulting in the first sustained human infection with the virus that would emerge as HIV-1M. We argue here that the "cut hunter" relies on a historical misunderstanding and ecological oversimplification of human-chimpanzee (Pan Troglodytes troglodytes) interactions that facilitated pathogenic transmission. This initial host shift cannot explain the beginnings of the HIV/AIDS pandemic. Instead, we must understand the processes by which the virus became transmissible, possibly between Sangha basin inhabitants and ultimately reached Kinshasa. A historical epidemiology of the late nineteenth and twentieth centuries, provides a much-needed corrective to the major shortcomings of the cut hunter. Based on 62 oral historical interviews conducted in southeastern Cameroon and archival research, we show that HIV emerged from ecological, economic, and socio-political transformations of the late nineteenth and twentieth centuries. The gradual imposition of colonial rule built on and reoriented ecologies and economies, and altered older patterns of mobility and sociality. Certain changes may have contributed to the initial viral host shift, but more importantly, facilitated the adaptation of HIV-1M to human-to-human transmission. Our evidence suggests that the most critical changes occurred after 1920. This argument has important implications for public health policy, underscoring recent work emphasizing alternative pathways for zoonotic spillovers into human beings.

  10. Experimental evaluation of a system for human life detection under debris (United States)

    Joju, Reshma; Konica, Pimplapure Ramya T.; Alex, Zachariah C.


    It is difficult to for the human beings to be found under debris or behind the walls in case of military applications. Due to which several rescue techniques such as robotic systems, optical devices, and acoustic devices were used. But if victim was unconscious then these rescue system failed. We conducted an experimental analysis on whether the microwaves could detect heart beat and breathing signals of human beings trapped under collapsed debris. For our analysis we used RADAR based on by Doppler shift effect. We calculated the minimum speed that the RADAR could detect. We checked the frequency variation by placing the RADAR at a fixed position and placing the object in motion at different distances. We checked the frequency variation by using objects of different materials as debris behind which the motion was made. The graphs of different analysis were plotted.

  11. Osteogenesis imperfecta at the beginning of bone and joint decade. (United States)

    Primorac, D; Rowe, D W; Mottes, M; Barisić, I; Anticević, D; Mirandola, S; Gomez Lira, M; Kalajzić, I; Kusec, V; Glorieux, F H


    Osteogenesis imperfecta (OI), or brittle bone disease, is a heritable disorder characterized by increased bone fragility. Four different types of the disease are commonly distinguished, ranging from a mild condition (type I) to a lethal one (type II). Types III and IV are the severe forms surviving the neonatal period. In most cases, there is a reduction in the production of normal type I collagen or the synthesis of abnormal collagen as a result of mutations in the type I collagen genes. These classic forms of OI are described in this review. There are instances, however, where alterations in bone matrix components, other than type I collagen, are the basic abnormalities of the OI. Recently, three such discrete types have been identified by histomorphometric evaluation (types V and VI) and linkage analysis (Rhizomelic OI). They provide evidence for the as yet poorly understood complexity of the phenotype-genotype correlation in OI. We also discuss bisphosphonates treatment as well as fracture management and surgical correction of deformities observed in the patients with OI. However, ultimately, strengthening bone in OI will involve steps to correct the underlying genetic mutations that are responsible for this disorder. Thus, we also describe different genetic therapeutic approaches that have been tested either on OI cells or on available OI murine models.

  12. Collective Defense of the Baltic States: A SOF Beginning (United States)


    support this collective effort. Endnotes 1 David Capezza,”Translating Russia’s military reform”, 2009, blog/journal...War II, (St.Paul, MN, Zenith Press 2007), 20. 53 John Nadler , Perfect Hell. The True Story of the Black Devils, the Forefathers of the Special

  13. [Beginnings of bariatric and metabolic surgery in Spain]. (United States)

    Baltasar, Aniceto; Domínguez-Adame, Eduardo


    When bariatric and metabolic surgery initially began in Spain, it was a subject of debate, due to not knowing exactly who were the first surgeons to perform it. A study has revealed the authors of the first interventions. Copyright © 2012 AEC. Published by Elsevier Espana. All rights reserved.

  14. Peer review at the beginning of the 21st century

    Directory of Open Access Journals (Sweden)

    Irene Hames


    Full Text Available Vigorous debate currently surrounds peer review, and polarized views are often expressed. Despite criticisms about the process, studies have found that it is still valued by researchers, with rigorous peer review being rated by authors as the most important service they expect to receive when paying to have their papers published open access. The expectations of peer review and what it can achieve need, however, to be realistic. Peer review is also only as good and effective as the people managing the process, and the large variation in standards that exists is one of the reasons some of the research and related communities have become critical of and disillusioned with the traditional model of peer review. The role of the editor is critical. All editors must act as proper editors, not just moving manuscripts automatically through the various stages, but making critical judgements throughout the process to reach sound and unbiased editorial decisions. New models and innovations in peer review are appearing. Many issues, however, remain the same: rigorous procedures and high ethical standards should be in place, those responsible for making decisions and managing the process need to be trained to equip them for their roles and responsibilities, and systems need to be adapted to deal with new challenges such as the increasing amounts of data being generated and needing to be taken into account when assessing the validity and soundness of work and the conclusions being drawn.

  15. Displacement effects of heavy human use on coral reef predators within the Molokini Marine Life Conservation District. (United States)

    Filous, Alexander; Friedlander, Alan M; Koike, Haruko; Lammers, Marc; Wong, Adam; Stone, Kristy; Sparks, Russell T


    The impact of marine ecotourism on reef predators is poorly understood and there is growing concern that overcrowding in Marine Protected Areas (MPAs) may disturb the species that these areas were established to protect. To improve our understanding of this issue, we used acoustic telemetry to examine the relationship between human activity at the Molokini Marine Life Conservation District (MLCD) and the habitat use of five reef-associated predators (Caranx melampygus, Caranx ignobilis, Triaenodon obesus, Carcharhinus amblyrhynchos, and Aprion virscens). During peak hours of human use, there was a negative relationship (R 2 =0.77, P<0.001) between the presence of bluefin trevally (Caranx melampygus) and vessels in subzone A. No other species showed strong evidence of this relationship. However, our results suggest that during this time, the natural ecosystem function that the reserve was established to protect may be compromised and overcrowding should be considered when managing MPAs. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. Beginnings of rocket development in the czech lands (Czechoslovakia) (United States)

    Plavec, Michal


    Although the first references are from the 15th Century when both Hussites and crusaders are said to have used rockets during the Hussite Wars (also known as the Bohemian Wars) there is no strong evidence that rockets were actually used at that time. It is worth noting that Konrad Kyeser, who described several rockets in his Bellifortis manuscript written 1402-1405, served as advisor to Bohemian King Wenceslas IV. Rockets were in fact used as fireworks from the 16th century in noble circles. Some of these were built by Vavřinec Křička z Bitý\\vsky, who also published a book on fireworks, in which he described how to build rockets for firework displays. Czech soldiers were also involved in the creation of a rocket regiment in the Austrian (Austro-Hungarian) army in the first half of the 19th century. The pioneering era of modern rocket development began in the Czech lands during the 1920s. The first rockets were succesfully launched by Ludvík Očenášek in 1930 with one of them possibly reaching an altitude of 2000 metres. Vladimír Mandl, lawyer and author of the first book on the subject of space law, patented his project for a stage rocket (vysokostoupající raketa) in 1932, but this project never came to fruition. There were several factories during the so-called Protectorate of Bohemia and Moravia in 1939-1945, when the Czech lands were occupied by Nazi Germany, where parts for German Mark A-4/V-2 rockets were produced, but none of the Czech technicians or constructors were able to build an entire rocket. The main goal of the Czech aircraft industry after WW2 was to revive the stagnant aircraft industry. There was no place to create a rocket industry. Concerns about a rocket industry appeared at the end of the 1950s. The Political Board of the Central Committee of the Czechoslovak Communist Party started to study the possibilities of creating a rocket industry after the first flight into space and particularly after US nuclear weapons were based in Italy

  17. Beginnings of remote handling at the RAL Spallation Neutron Source

    International Nuclear Information System (INIS)

    Liska, D.J.; Hirst, J.


    Expenditure of funds and resources for remote maintenance systems traditionally are delayed until late in an accelerator's development. However, simple remote-surveillance equipment can be included early in facility planning to set the stage for future remote-handling needs and to identify appropriate personnel. Some basic equipment developed in the UK at the Spallation Neutron Source (SNS) that serves this function and that has been used to monitor beam loss during commissioning is described. A photograph of this equipment, positioned over the extractor septum magnet, is shown. This method can serve as a pattern approach to the problem of initiating remote-handling activities in other facilities

  18. Some Competition Programming Problems as the Beginning of Artificial Intelligence




    We consider in this paper some programming competition problems (which are near to some problems of ACM competitions) of the following subjects: we can make their solution using both Prolog and a classical procedure-oriented language. Moreover, the considered problems are selected that their solution in Prolog and in a classical procedure-oriented language are similar - i.e., in other words, they use the same working mechanism, the same approach to constructing recursive functions etc. Howeve...

  19. The Beginning of the End for Digital Forensic Recovery?

    Directory of Open Access Journals (Sweden)

    Graeme Baxter Bell


    Full Text Available Normal 0 false false false EN-AU X-NONE X-NONE Digital evidence is increasingly relied upon in computer forensic examinations and legal proceedings in the modern courtroom. The primary storage technology used for digital information has remained constant over the last two decades, in the form of the magnetic disc. Consequently, investigative, forensic, and judicial procedures are well-established for magnetic disc storage devices (Carrier, 2005. However, a paradigm shift has taken place in technology storage and complex, transistor-based devices for primary storage are now increasingly common. Most people are aware of the transition from portable magnetic floppy discs to portable USB transistor flash devices, yet the transition from magnetic hard drives to solid-state drives inside modern computers has so far attracted very little attention from the research community.Here we show that it is imprudent and potentially reckless to rely on existing evidence collection processes and procedures, and we demonstrate that conventional assumptions about the behaviour of storage media are no longer valid. In particular we demonstrate that modern storage devices can operate under their own volition in the absence of computer instructions. Such operations are highly destructive of traditionally recoverable data. This can contaminate evidence; can obfuscate and make validation of digital evidence reports difficult; can complicate the process of live and dead analysis recovery; and can complicate and frustrate the post recovery forensic analysis. Our experimental findings demonstrate that solid-state drives (SSDs have the capacity to destroy evidence catastrophically under their own volition, in the absence of specific instructions to do so from a computer.

  20. The beginnings of dermatopathology and dermatologic microbiology in Spain. (United States)

    del Río, E


    Crisóstomo Martínez from Valencia was a pioneering microscopist in 17th-century Europe. The first microscopic representations of skin in Spain appeared in an 18th-century work by Martín Martínez. Microbiology and histopathology progressed considerably in the late 19th century thanks to anatomists like Maestre de San Juan and surgeons like Federico Rubio Galí. The first Spanish pathologist to specialize in dermatology was Antonio Mendoza, a colleague of José Eugenio de Olavide at the Hospital San Juan de Dios in Madrid. Claudio Sala and Juan de Azúa also made significant contributions, including the description of pseudoepithelioma. Several disciples of Santiago Ramón y Cajal and Jorge FranciscoTello, such as Lorenzo Ruiz de Arcaute and Guillermo de la Rosa King, consolidated the dermatology laboratory, but the Civil War sent many into exile or deprived them of their professional status. Juan Rubió in Barcelona and Julio Rodríguez Puchol in Madrid were the immediate predecessors of today's dermatopathologists. Copyright © 2012 Elsevier España, S.L. y AEDV. All rights reserved.

  1. [The beginnings and development of diagnostic imaging in nuclear medicine]. (United States)

    Stefanović, L


    The phenomenon of radioactivity was discovered in 1896 by Antoin Henri Becquerel, but its application in visual diagnostics started about fifty years later. It was constructed by B. Cassen and ass. in 1949, when first scintiscans were obtained. Technical improvements have been made 1950-1956 (B. Cassen and ass., R. Newall and ass., P. Bell, D. Kuhl). Soon after appearance of the first Cassen's scanner, commercial production began. It was invented and constructed by H. Anger in 1957, improvements being made from 1958 to 1963. Gamma cameras are being commercially produced and sold since 1962; about ten years later they become widely used, and soon they pushed out the scanner from visual diagnostics. COMPUTER: Its use in scintigraphic diagnostics started in 1964 (H. Shepers, D. Wincler, D. Brown). From 1965 to 1974 various centers developed their own computer programs; after 1974 computers with incorporated nuclear medicine software packages became commercially available. Numerous attempts to obtain tomographic images of organs using scanners and gamma cameras were made between 1963 and 1973 (D. Kuhl and R. Edwards, H. Anger, N. Charkes and R. Somburanasin et al.). The concept of contemporary single photon emission tomography (SPET) device was developed between 1974 and 1977 (J. Keyes and ass. and R. Jaszczak and ass.), while commercial production started in 1982. First cyclotrons for production of positron emitters, a prerequisite for positron emission tomography (PET) diagnostics, emerged in hospitals in 1955, and in last ten years they are being commercially made for these purposes. H. Anger (1959), M. Phelps, E. Hoffman and M. Ter-Pogossian (1975) set the grounds of PET; commercial production of PET systems started thereafter. Visual diagnostics in nuclear medicine reached its zenith in clinical practice during 1970-1980. It is partly pushed into the background by new imaging techniques (US, CT, MRI), but it only initiated further improvements (SPET, PET).

  2. Prime-Time Science: The Beginning of a Beautiful Friendship? (United States)

    Ouellette, Jennifer


    The portrayal of science has often posed a challenge to Hollywood. Though it has provided some of the compelling storylines, the many complexities of science (and scientists) have confounded even the most talented writer or director, pitting creative license against scientific accuracy again and again. Likewise, the scientific community has struggled to find a conduit through which it can communicate its story to the general public on a mass scale. To bridge this gap, the National Academy of Sciences has partnered with leading Hollywood professionals to launch The Science and Entertainment Exchange; its mission is to connect entertainment industry professionals with top scientists from across the country to foster creative collaborations. The timing has never been better: there is a plethora of network TV shows currently on the air with science-based themes and plot lines, and a renewed interest -- even with science fiction films and TV -- in coming up with more plausible futuristic scenarios. Working together, the two communities can create a ``win-win'' synergy between accurate science and engaging entertainment.

  3. A letter signed: the very beginnings of Dalton's atomic theory. (United States)

    Pratt, Herbert T


    This paper explores the provenance and content of a previously unknown personal letter by John Dalton (1766-1844), which is dated 12 April 1803. It relates to a startling breakthrough in Dalton's research, which pre-dates by five months the earliest date in his laboratory notebook, namely, 6 September 1803. The author acquired the letter about thirty years ago, and now offers it to the public. He makes no attempt to explain how it contributes to--or even changes--our understanding of Dalton, but leaves that privilege to Dalton scholars.

  4. The End of Public Schools? Or a New Beginning? (United States)

    Hursh, David; Martina, Camille Anne


    Public education is becoming increasingly privatized as private philanthropic organizations, such as the Bill & Melinda Gates Foundation, and corporations, such as Pearson, dominate the policy-making process, and more students enroll in publicly funded but privately administered charter schools. The privatization of education results from the…

  5. A Comparison of Metrics for Scoring Beginning Spelling (United States)

    Ritchey, Kristen D.; Coker, David L., Jr.; McCraw, Sara B.


    The authors investigated four spelling scoring metrics: total words correct, correct letter sequences, correct sounds, and phonological coding scoring (developed by Tangel and Blachman) across two studies with children in kindergarten. The relationships between spelling scores and measures of reading, phonological awareness, and writing skills…

  6. Semiconductor micropattern pixel detectors: a review of the beginnings

    International Nuclear Information System (INIS)

    Heijne, E.H.M.


    The innovation in monolithic and hybrid semiconductor 'micropattern' or 'reactive' pixel detectors for tracking in particle physics was actually to fit logic and pulse processing electronics with μW power on a pixel area of less than 0.04 mm 2 , retaining the characteristics of a traditional nuclear amplifier chain. The ns timing precision in conjunction with local memory and logic operations allowed event selection at >10 MHz rates with unambiguous track reconstruction even at particle multiplicities >10 cm -2 . The noise in a channel was ∼100e - rms and enabled binary operation with random noise 'hits' at a level -8 . Rectangular pixels from 75 μmx500 μm down to 34 μmx125 μm have been used by different teams. In binary mode a tracking precision from 6 to 14 μm was obtained, and using analog interpolation one came close to 1 μm. Earlier work, still based on charge integrating imaging circuits, provided a starting point. Two systems each with more than 1 million sensor + readout channels have been built, for WA97-NA57 and for the Delphi very forward tracker. The use of 0.5 μm and 0.25 μm CMOS and enclosed geometry for the transistors in the pixel readout chips resulted in radiation hardness of ∼2 Mrad, respectively, >30 Mrad

  7. Jacopo da Firenze and the Beginning of Italian Vernacular Algebra

    DEFF Research Database (Denmark)

    Høyrup, Jens


    , furthermore not pointing toward what we may (for lack of a better term)call the "high" Arabic tradition (al-Khwarizmi, Abu Kamil,al-Khayyami), that tradition which is reflected in Latin translations. 3.It contains no single Arabism - whence we may conclude that the Arabic inspiration was not direct...

  8. Qualities of life, educational level and human development: an international investigation of health. (United States)

    Skevington, Suzanne M


    This study investigated the relationship between health-related quality of life (QoL), educational level and culture, using a high quality cross-cultural generic measure (WHOQOL-BREF) containing 25 international dimensions organised in physical, psychological, social and environmental domains. Cross-cultural data from 9,404 sick and well adults in 13 countries showed that environmental QoL increased positively and sequentially from no education to tertiary education. The other three domains increased only up to secondary school level. These MANCOVA results were significantly influenced by health status, age, culture and economic development level. More positive feelings, less dependence on medication and treatment, better perceptions of financial resources, physical environment, and opportunities for information and skills, represent adult QoL advantages to those who received tertiary education compared with secondary schooling. Developing countries reported poorer environmental, psychological and physical QoL than developed countries, although social QoL was good, and no different for the two development bands. Only psychological QoL distinguished between every educational level, in developing countries. Increased positive feelings serve to link better mental health with more education. Across each domain, secondary and tertiary education was associated with better QoL in developing countries. The results support a QoL case for universal secondary education on which better health and health care may be built.

  9. The valuation of nursing begins with identifying value drivers. (United States)

    Rutherford, Marcella M


    Adequate investment in a profession links to its ability to define and document its value. This requires identifying those elements or value drivers that demonstrate its worth. To completely identify nursing's value drivers requires meshing the economic, technical, and caring aspects of its profession. Nursing's valuation includes assessing nursing's tangible and intangible assets and documenting these assets. This information communicates nursing's worth and ensures adequate economic investment in its services.

  10. Bonding Ideas About Inquiry: Exploring Knowledge and Practices of Metacognition in Beginning Secondary Science Teachers (United States)

    Rivero Arias, Ana Margarita

    Metacognition, identified generally as "thinking about thinking", plays a fundamental role in science education. It enhances the understanding of science as a way to generate new knowledge using scientific concepts and practices. Moreover, metacognition supports the development of students' life-long problem solving, collaboration, and critical thinking skills. When teachers use metacognition with intention, it can promote students' agency and responsibility for their own learning. However, despite all of its benefits, metacognition is rarely seen in secondary science classrooms. Thus, it is important to understand what beginning teachers know and how they use metacognition during their first years in order to find ways to prepare and support them in incorporating metacognitive practices into their science teaching. The purpose of this multimethod study was to describe the metacognitive knowledge and experiences of beginning science teachers. For the quantitative research strand, I surveyed 36 secondary science teachers about their awareness of metacognition and used classroom observations coded from a larger research study to identify how often teachers were using metacognition to teach science. For the qualitative strand, I interviewed 15 participants about their knowledge and experiences of metacognition (including reflective practices) and spent two weeks observing two of the teachers who described exemplary metacognitive teaching practices. I found that participants had a solid awareness of metacognition, but considered the term complicated to enact, difficult for students, and less important to focus on during their first years of teaching than other elements such as content. Additionally, teaching experience seemed to have an effect on teachers' knowledge and experiences of metacognition. However, participants who were using metacognitive practices had recognized their importance since the beginning of their teaching. Reflective practices can help improve

  11. The beginning of a new era - OTC's satellite business services (United States)

    Bachmann, Erik

    OTC has developed a new range of digital services which will provide business organizations in Australia with high quality private international telecommunications. This range will be known as Satnet and the paper deals with Satnet 2 which is the service offerings using medium-size earth stations (nominally 5- and 7-meter antenna apertures), installed at customers' premises. These services will rely on the Intelsat 6/4 GHz space segment. Operation will be totally digital and will be integrated with no distinction between individual applications such as voice, data, video, etc. Carrier capacities between 64 kb/s and 8.448 Mb/s can be provided and ISDN performance requirements can be supported. The paper describes key service features, systems design and transmission analysis. Consideration is also given to operation, installation and frequency coordination aspects.

  12. The induction of teacher educators: the needs of beginning teacher educators

    NARCIS (Netherlands)

    Van Velzen, Corinne; Van der Klink, Marcel; Swennen, Anja; Yaffe, Elka


    Van Velzen, C., Van der Klink, M., Swennen, A., & Yaffe, E. (2008). The induction of teacher educators: the needs of beginning teacher educators. Paper presented at the ATEE Conference. August, 24, 2008, Brussels, Belgium.

  13. Life Written in Bytes . The Superinformacional and New Technologies Company : Will the End of Privacy and Human Dignity ?

    Directory of Open Access Journals (Sweden)

    Cleide Aparecida Gomes Rodrigues Fermentão


    Full Text Available Recent technologies have changed the way media of the human being, which shall establish direct contact with many people anywhere in the world. Allied to this fact, there is a virtualization increasing the human person, culminating in an immersion in the virtual world, which ultimately creates an increasing dependence on technology in order to exist socially. This transformation in the world of concepts makes the virtual pass to have direct impact in the real world. Attracted by the glitter and glamor of virtual network, the person finds no limits to their self-promotion. The private life is increasingly exposed to an undetermined number of people. So the person who is exposed in the virtual media in search of acceptance, forgets that it is not only stripping of his clothes or his privacy, but mainly is stripped of his dignity. The frantic search for some "tanned" finds no limit on common sense, coisificando the person and transforming it into mere virtual profile. The human person is in this state, the total lack of dignity, without realizing it, it becomes an object on display. The internet is a stage conducive to the spectacle of the self virtual, making it fertile ground for the indignity. The history of civilization dating back to fighting and winning the dignity of the human person, however, the time in which we live watch a reverse movement. Contemporaneously it is no longer the state or private to be constant threat to human dignity. Those who, seduced by the possibility of becoming the personality of the time, voluntarily abdicate their dignity in a process whose reversibility is questionable. The legislation can not keep up the speed of the transformations occurred in the virtual world and this mismatch can leave unprotected person especially in relation to their rights to intimacy, privacy and human dignity itself.

  14. (DeHumanizing Humor: The Anthill of Life and Politics in the Theatre of Sabina Berman

    Directory of Open Access Journals (Sweden)

    Priscilla Meléndez


    Full Text Available This article examines several theatrical works of this Mexican dramatist by means of ironic humor as a powerful resource to examine the nature of human communication, and to expose the serious and devastating social and political aspects of contemporary culture: machismo, political corruption, sexual violence, sexism, exploitation, historical manipulation, and hopelessness. In a tense environment where humor might not seem appropriate, Berman masterfully uses and critically examines it as a means to understand humor’s serious implications and its comic imperfections, as she subtly recurs to but also parodies some of the most recognized theories of humor. Berman’s use of incongruity highlights the tension in her theatrical production, in which even the most sordid acts are counterbalanced by irony, which produces not only surprise or pain in the face of the unexpected, but also pleasure. Perhaps that is why she incorporates the image of the anthill in her reflections about society, politics, history, sexuality, gender identity, and art, where the artist, with her double perspective, like the queen of the “Formicas exsectoides,” is able to interpret the world from both the inside and the outside.

  15. Hudson River Unionids and Zebra Mussels: The Beginning of the End or the End of the Beginning? (United States)

    Strayer, D. L.; Malcom, H. M.


    The invasion of the Hudson River estuary by zebra mussels was followed by steep declines (77 to >99.7%) in populations of all species of native bivalves between 1992 and 1999. Body condition of all unionids, and growth and recruitment of young unionids also declined significantly. Declines in population size and body condition were correlated primarily with the filtration rate of the zebra mussel population, not with fouling of native bivalves by zebra mussels. Samples taken since 2000, however, have shown that populations of all 4 common native bivalves have stabilized or even recovered, although the zebra mussel population has not declined. The mechanisms underlying this apparent reversal of fortune are not clear: recruitment and growth of young mussels have showed limited recovery, but body condition of adults has not. We found no evidence that spatial refuges contributed to this reversal of population declines. Simple statistical models project now that native bivalves may persist at population densities about an order of magnitude below their pre-invasion densities.

  16. [Transformations of the relationships between medicine and physical activities from the beginning of the 19th C. to the beginning of the 20th C. in France]. (United States)

    Defrance, Jacques; Brier, Pascal; El Boujjoufi, Taieb


    In order to understand the modes of cooperation that are practically working between two groups with uneven social status, physicians and physical educators, since the beginning of the 19th century until the beginning of the 20th century, we consider the results of researches that have been realized since three decennials. The evolution of those relationships accomplishes itself while the definition of respective roles (physician hygienist, physical educator with sanitary conception) and the reciprocal adjustment of specialities are becoming more precise. The process is tight, and the adaptations of the respective tasks are continuously retranslated in terms of statuary dimensions and protection of respective jurisdictions of both groups in the process of professionalization.

  17. Limits to Human Life Span Through Extreme Value Theory

    NARCIS (Netherlands)

    Einmahl, Jesson; Einmahl, John; de Haan, L.F.M.


    There is no scientific consensus on the fundamental question whether the probability distribution of the human life span has a finite endpoint or not and, if so, whether this upper limit changes over time. Our study uses a unique dataset of the ages at death - in days - of all (about 285,000) Dutch

  18. Water Quality Criteria for Human Health and Aquatic Life (United States)

    Collaborative effort with the Office of Water to provide science in support of the development and implementation of new or revised ambient water quality criteria for microbial and chemical contaminants for human health and aquatic life. The research also addresses implementation...

  19. Life-span changes of the human brain white matter: diffusion tensor imaging (DTI) and volumetry. (United States)

    Westlye, Lars T; Walhovd, Kristine B; Dale, Anders M; Bjørnerud, Atle; Due-Tønnessen, Paulina; Engvig, Andreas; Grydeland, Håkon; Tamnes, Christian K; Ostby, Ylva; Fjell, Anders M


    Magnetic resonance imaging volumetry studies report inverted U-patterns with increasing white-matter (WM) volume into middle age suggesting protracted WM maturation compared with the cortical gray matter. Diffusion tensor imaging (DTI) is sensitive to degree and direction of water permeability in biological tissues, providing in vivo indices of WM microstructure. The aim of this cross-sectional study was to delineate age trajectories of WM volume and DTI indices in 430 healthy subjects ranging 8-85 years of age. We used automated regional brain volume segmentation and tract-based statistics of fractional anisotropy, mean, and radial diffusivity as markers of WM integrity. Nonparametric regressions were used to fit the age trajectories and to estimate the timing of maximum development and deterioration in aging. Although the volumetric data supported protracted growth into the sixth decade, DTI indices plateaued early in the fourth decade across all tested regions and then declined slowly into late adulthood followed by an accelerating decrease in senescence. Tractwise and voxel-based analyses yielded regional differences in development and aging but did not provide ample evidence in support of a simple last-in-first-out hypothesis of life-span changes.

  20. How Do Volcanoes Affect Human Life? Integrated Unit. (United States)

    Dayton, Rebecca; Edwards, Carrie; Sisler, Michelle

    This packet contains a unit on teaching about volcanoes. The following question is addressed: How do volcanoes affect human life? The unit covers approximately three weeks of instruction and strives to present volcanoes in an holistic form. The five subject areas of art, language arts, mathematics, science, and social studies are integrated into…

  1. Exoplanets, Exo-Solar Life, and Human Significance (United States)

    Wiseman, Jennifer


    With the recent detection of over 500 extrasolar planets, the existence of "other worlds", perhaps even other Earths, is no longer in the realm of science fiction. The study of exoplanets rapidly moved from an activity on the fringe of astronomy to one of the highest priorities of the world's astronomical programs. Actual images of extrasolar planets were revealed over the past two years for the first time. NASA's Hubble Space Telescope is already characterizing the atmospheres of Jupiter-like planets, in other systems. And the recent launch of the NASA Kepler space telescope is enabling the first statistical assessment of how common solar systems like our own really are. As we begin to characterize these "other worlds" and assess their habitability, the question of the significance and uniqueness of life on Earth will impact our society as never before. I will provide a comprehensive overview of the techniques and status of exoplanet detection, followed by reflections as to the societal impact of finding out that Earths are common, or rare. Will finding other potentially habitable planets create another "Copernican Revolution"? Will perceptions of the significance of life on Earth change when we find other Earth-like planets? I will discuss the plans of the scientific community for future telescopes that will be abe to survey our solar neighborhood for Earth-like planets, study their atmospheres, and search for biological signs of life.

  2. Environmental impact of estrogens on human, animal and plant life: A critical review. (United States)

    Adeel, Muhammad; Song, Xiaoming; Wang, Yuanyuan; Francis, Dennis; Yang, Yuesuo


    Since the inception of global industrialization, steroidal estrogens have become an emerging and serious concern. Worldwide, steroid estrogens including estrone, estradiol and estriol, pose serious threats to soil, plants, water resources and humans. Indeed, estrogens have gained notable attention in recent years, due to their rapidly increasing concentrations in soil and water all over the world. Concern has been expressed regarding the entry of estrogens into the human food chain which in turn relates to how plants take up and metabolism estrogens. In this review we explore the environmental fate of estrogens highlighting their release through effluent sources, their uptake, partitioning and physiological effects in the ecological system. We draw attention to the potential risk of intensive modern agriculture and waste disposal systems on estrogen release and their effects on human health. We also highlight their uptake and metabolism in plants. We use MEDLINE and other search data bases for estrogens in the environment from 2005 to the present, with the majority of our sources spanning the past five years. Published acceptable daily intake of estrogens (μg/L) and predicted no effect concentrations (μg/L) are listed from published sources and used as thresholds to discuss reported levels of estrogens in the aquatic and terrestrial environments. Global levels of estrogens from river sources and from Waste Water Treatment Facilities have been mapped, together with transport pathways of estrogens in plants. Estrogens at polluting levels have been detected at sites close to waste water treatment facilities and in groundwater at various sites globally. Estrogens at pollutant levels have been linked with breast cancer in women and prostate cancer in men. Estrogens also perturb fish physiology and can affect reproductive development in both domestic and wild animals. Treatment of plants with steroid estrogen hormones or their precursors can affect root and shoot

  3. Professional concerns of beginning teachers of deaf and hard of hearing students. (United States)

    Guteng, Simon I


    The professional concerns of beginning teachers of students who are deaf or hard of hearing were examined. Five first-year teachers of deaf and hard of hearing students served as participants. Two of the participants were itinerant teachers; three taught in self-contained classrooms. Participants were selected from programs serving deaf and hard of hearing students in rural and urban areas of the midwestern and southwestern United States. To interview the study participants, the researcher used an in-depth phenomenological method employing semi-structured questions and guided by a constructivist paradigm. Data were analyzed using qualitative analysis strategies (Bogdan & Biklen, 1992; Miles & Huberman, 1994). Results showed that concerns of beginning teachers of deaf and hard of hearing students are specific to service delivery models and geography. Participants provided specific recommendations for addressing the concerns of beginning teachers of deaf and hard of hearing students.

  4. The Metaphorical Applications of Heavenly Bodies and Phenomena in Western Armenian Poetry at the Beginning of the XX Century (United States)

    Arakelyan, Karine


    The metaphorical applications of heavenly bodies and phenomena in Western Armenian poetry at the beginning of the XX century are very diverse and of great variety. Art Workers eulogize the creation of God, admire the beauty of stars, and perceive the man as a part of nature and in the close connection with all other parts. These units are often used for bringing to light one's inner life, his old gone paths, expectations and hopes, many times they become the heart and the basis of poetical image and create unique beauty.

  5. IVF culture medium affects post-natal weight in humans during the first 2 years of life. (United States)

    Kleijkers, Sander H M; van Montfoort, Aafke P A; Smits, Luc J M; Viechtbauer, Wolfgang; Roseboom, Tessa J; Nelissen, Ewka C M; Coonen, Edith; Derhaag, Josien G; Bastings, Lobke; Schreurs, Inge E L; Evers, Johannes L H; Dumoulin, John C M


    Is post-natal growth during the first 2 years of life in IVF singletons affected by type of medium used for culturing human embryos during an IVF treatment? The in vitro culture of human embryos in medium from Cook resulted in singletons with a lower weight during the first 2 years of life compared with singletons born after embryo culture in medium from Vitrolife. In a previous study, we reported that type of medium used for culturing human IVF embryos during the first few days after fertilization until fresh embryo transfer significantly affects fetal growth and consequently birthweight of the resulting singletons. From July 2003 to December 2006, a total of 1432 IVF treatment cycles with fresh embryo transfer were randomly allocated to have all embryos cultured in medium from Vitrolife AB (n = 715) or from Cook (n = 717). Two years after delivery, questionnaires were sent to the parents of all children requesting data about weight, height and head circumference around 1, 2, 3, 4, 6, 7.5, 9, 11, 14, 18 and 24 months of age. These measurements were collected as part of the children's health programme at municipal infant welfare centres in the Netherlands by health professionals unaware of this study. Patients requiring donor oocytes or applying for PGD were excluded from the study. From the 294 live born singletons that fulfilled our inclusion criteria, 29 were lost to follow-up. The remaining 265 singletons (Cook group: 117, Vitrolife group: 148) were included in the analysis. Data analysis included linear regression, to compare cross-sectionally weight standard deviation score (SDS), height SDS and head circumference, and the first order Berkey-Reed model for a longitudinal analysis of the growth data. Singletons in the Vitrolife group were heavier during the first 2 years of life compared with singletons in the Cook group. Cross-sectional analyses showed that adjusted weight SDS differed between groups at 1 (0.35 ± 0.14, P = 0.010), 2 (0.39 ± 0.14, P = 0

  6. Industrial energy use and the human life history. (United States)

    Burger, Oskar; Delong, John P; Hamilton, Marcus J


    The demographic rates of most organisms are supported by the consumption of food energy, which is used to produce new biomass and fuel physiological processes. Unlike other species, modern humans use 'extra-metabolic' energy sources acquired independent of physiology, which also influence demographics. We ask whether the amount of extra-metabolic energy added to the energy budget affects demographic and life history traits in a predictable way. Currently it is not known how human demographics respond to energy use, and we characterize this response using an allometric approach. All of the human life history traits we examine are significant functions of per capita energy use across industrialized populations. We find a continuum of traits from those that respond strongly to the amount of extra-metabolic energy used, to those that respond with shallow slopes. We also show that the differences in plasticity across traits can drive the net reproductive rate to below-replacement levels.

  7. Beginning elementary school teachers' perceptions of structural and cultural context factors impacting their science teaching (United States)

    Sterling, Hillary A.

    Science maintains low status in many elementary classrooms. Beginning teachers find it difficult to teach science effectively. The Teacher-Centered Systemic Reform Model suggests there are personal, structural, and cultural factors that impact teaching practices. The questions that drove this study were: (a) How do beginning teachers perceive structural and cultural factors of the TCSR model as affecting their science teaching practices? (b) How do those perceptions compare between beginning teachers who teach science and those who do not? (c) How do beginning teachers' perceptions compare to those of principals and veteran teachers? The model was used to collect and analyze data on the perceptions of factors that influenced beginning teachers' science teaching practices. A case study involved six beginning teachers from three elementary schools in the southwestern United States during the 2005--2006 school year. Through an initial survey, two groups of beginning teachers were first identified as (a) those who taught and liked science, and (b) those who did not teach or like science. Three teachers from each group were selected to participate in the study that consisted of semi-structured interviews, observations, and review of artifacts. These data were compared with interview data from three veteran teachers and three principals. The findings of this study supported the TCSR model and confirmed that the beginning teachers did perceive certain structural context factors (e.g., curriculum, materials, time, professional development, district requirements, classroom management), and cultural context factors (e.g., district-wide low priority of science) as having an impact on their science teaching. The veteran teachers' perceptions more closely matched those of the beginning teachers' than did those of the principals. Despite the contextual influences, the beginning teachers' perceptions ultimately differed in teacher thinking (i.e., those who taught science had

  8. How do relationships begin?

    NARCIS (Netherlands)

    Holmen, Elsebeth; Roos, Kaspar; Kallevag, Magne; von Raesfeld Meijer, Ariane M.; de Boer, L.; Pedersen, Ann-Charlott


    In this paper we address the issue ‘How do relationships begin?’ Based on a review of work within theIMP Approach on stage and state models of relationship evolution, we conclude that very littleattention has been paid to beginnings of relationships. We discuss why this might be so, and why theissue

  9. Comparison Study of Body Image Satisfaction Between Beginning- and Advanced-Level Female Ballet Students. (United States)

    Radell, Sally A; Keneman, Margaret L; Mandradjieff, Mara P; Adame, Daniel D; Cole, Steven P


    This mixed methods study compares the level of satisfaction with one's body image between beginning- and advanced-level female collegiate ballet students. Thirty-six beginning-level students were enrolled in two ballet classes, and a second group of 16 advanced-level students was enrolled in a third class. A mirror was used in the teaching of both groups. During the first and thirteenth week of a 14-week semester, students completed the Cash 69-item Body Self-Relations Questionnaire. In addition, five students from each group were randomly selected to participate in semi-structured interviews during the second and last week of the semester. Researchers asked students questions about their kinesthetic experience and the mirror's role in the studio. The quantitative results indicated that over the course of the semester the beginning dancers decreased in feeling physically fit, while the advanced dancers felt more in shape. For both beginning and advanced dancers there was a decrease in body image satisfaction. By semester's end, the advanced dancers were more preoccupied with weight and exercised more than the beginning dancers. The interviews revealed that four out of the five beginning ballet students discussed the use of the mirror in class and reported experiencing thoughts and sensations characteristic of the objective self-awareness state, such as heightened self-consciousness, comparison of self to others, or negative self-evaluation. The advanced dancers, on the other hand, focused on developing ways to avoid the mirror and preferred to "feel" movements muscularly before using the mirror for feedback. Even though the advanced dancers had more knowledge of how to use a mirror beneficially in class, their body image scores were equally as compromised as the beginning students'. These results suggest that both beginning- and advanced-level ballet students experience a decrease in body image satisfaction in a mirrored studio environment.

  10. What Teachers Should Know about the Evolution-Intentional Design Debate on the Origin of Life. (United States)

    Brekke, Stewart E.

    This paper discusses the beginning of life on Earth, the formation of life forms, evolution, and the origin of life. The paper suggests that how life first appeared on earth is not known and may never be known. (YDS)

  11. Impetus for sowing and the beginning of agriculture: ground collecting of wild cereals. (United States)

    Kislev, Mordechai E; Weiss, Ehud; Hartmann, Anat


    The Agricultural Revolution in Western Asia, which took place some 11,000 years ago, was a turning point in human history [Childe, V. G. (1952) New Light on the Most Ancient East (Routledge & Kegan Paul, London)]. In investigating the cultural processes that could have led from gathering to intentional cultivation, various authors have discussed and tested wild cereal harvesting techniques. Some argue that Near Eastern foragers gathered grains by means of sickle harvesting, uprooting, plucking (hand stripping), or beating into baskets [Hillman, G. C. & Davies, M. S. (1999) in Prehistory of Agriculture: New Experimental and Ethnographic Approaches, ed. Anderson, P. (The Institute of Archaeology, University of California, Los Angeles), pp. 70-102]. During systematic experiments, we found that archaeobotanical data from regional Neolithic sites support ground collection of grains by early hunter-gatherers. Ground collecting suits the natural shattering of wild species that ripen and drop grains at the beginning of summer. We show that continual collection off the ground from May to October would have provided surplus grains for deliberate sowing in more desirable fields, and facilitate the transition to intentional cultivation. Because ground gathering enabled collectors to observe that fallen seeds are responsible for the growth of new plants in late fall, they became aware of the profitability of sowing their surplus seeds for next year's food. Ground collecting of wild barley and wild wheat may comprise the missing link between seed collecting by hunter-gatherers and cereal harvesting by early farmers.

  12. Human immune responses to vaccines in the first year of life: biological, socio-economic and ethical issues - a viewpoint. (United States)

    Ota, M O C; Idoko, O T; Ogundare, E O; Afolabi, M O


    Human newborns are vulnerable to infectious diseases that account for majority of the morbidity and mortality, particularly in first year of life. Vaccines have become the most effective public health intervention strategy to curtail the prevalence of these infectious diseases. Although vaccines against a number of diseases exist, there are no vaccines against many other diseases that commonly affect children. The adequate assessment of immune responses to vaccines is an important step in the development of vaccines. However, a number of biological and "non-medical" socio-economic and ethical factors could influence either the administration and/or evaluation of vaccines in infants. Recognition and understanding of these determinants are crucial in planning interventions and for logical interpretations of results. Copyright © 2012 Elsevier Ltd. All rights reserved.

  13. The probability of extraterrestrial life; La probabilidad de vida extraterrestre

    Energy Technology Data Exchange (ETDEWEB)

    Chavez B, A


    Since beginning of times, human beings need to live in the company of other humans, beings developing what we now know as human societies. According to this idea there has been speculation, specially in the present century, about the possibility that human society has company of the other thinking creatures living in other planets somewhere in our galaxy. In this talk we will only use reliable data from scientific observers in order to establish a probability. We will explain the analysis on the physico-chemical principles which allow the evolution of organic molecules in our planet and establish these as the forerunners of life in our planet. On the other hand, the physical process governing stars, their characteristics and their effects on planets will also be explained as well as the amount of energy that a planet receives, its mass, atmosphere and kind of orbit. Finally, considering all this information, a probability of life from outer space will be given. (Author)

  14. What Are You Worth? The Value of a Human Life and Its Impact on Personnel Recovery (United States)


    over time. For instance, consider the attitudes toward slaves and their value 200 years ago. 10   bioethicist Daniel Sulmasy, life is both...Air Missiles (SAMs).12 The EB-66 crews viewed their missions as “ milk runs” because they were near the Demilitarized Zone (DMZ) where the intensity

  15. Sexual services, drugs and human trafficking, smuggling – in GDP figures: Quality of life indicators

    Directory of Open Access Journals (Sweden)

    Vilks A.


    Full Text Available In recent years different kind of antisocial and criminal activities, according to the EU regulations, are being included in GDP indicators. The activities, included in GDP indicators are as follows: those of criminal nature (drugs, arms and human trafficking, corruptive activities, etc.; illegal activities, which are not of criminal nature (businesses without licenses and special permits, poaching, etc.; legal activities, though the income from them is not taxed and not recorded (prostitution, alcohol production, etc.; illegal use of intellectual property objects (illegal use of unlicensed programmes. Estimates on the inclusion of illegal, among them criminal activities in GDP indicators are important not only to learn the actual size of GDP, but also to give a chance to the law enforcement authorities to pay attention to separate areas of unregulated economic activities. The author of the article outlines the approximate extent of illegal and informal economic activities and their share in GDP, describes the methods of determination of the economic sector, as well as analyzes some separate informal economic sectors, which should be included into GDP.

  16. Bmi-1 extends the life span of normal human oral keratinocytes by inhibiting the TGF-{beta} signaling

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Reuben H., E-mail: [UCLA School of Dentistry, Los Angeles, CA 90095 (United States); UCLA Dental Research Institute, Los Angeles, CA 90095 (United States); UCLA Jonsson Comprehensive Cancer Center, Los Angeles, CA 90095 (United States); Lieberman, Mark B.; Lee, Rachel [UCLA School of Dentistry, Los Angeles, CA 90095 (United States); Shin, Ki-Hyuk [UCLA School of Dentistry, Los Angeles, CA 90095 (United States); UCLA Dental Research Institute, Los Angeles, CA 90095 (United States); UCLA Jonsson Comprehensive Cancer Center, Los Angeles, CA 90095 (United States); Mehrazarin, Shebli; Oh, Ju-Eun [UCLA School of Dentistry, Los Angeles, CA 90095 (United States); Park, No-Hee [UCLA School of Dentistry, Los Angeles, CA 90095 (United States); UCLA Dental Research Institute, Los Angeles, CA 90095 (United States); UCLA Jonsson Comprehensive Cancer Center, Los Angeles, CA 90095 (United States); David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 (United States); Kang, Mo K., E-mail: [UCLA School of Dentistry, Los Angeles, CA 90095 (United States); UCLA Dental Research Institute, Los Angeles, CA 90095 (United States); UCLA Jonsson Comprehensive Cancer Center, Los Angeles, CA 90095 (United States)


    We previously demonstrated that Bmi-1 extended the in vitro life span of normal human oral keratinocytes (NHOK). We now report that the prolonged life span of NHOK by Bmi-1 is, in part, due to inhibition of the TGF-{beta} signaling pathway. Serial subculture of NHOK resulted in replicative senescence and terminal differentiation and activation of TGF-{beta} signaling pathway. This was accompanied with enhanced intracellular and secreted TGF-{beta}1 levels, phosphorylation of Smad2/3, and increased expression of p15{sup INK4B} and p57{sup KIP2}. An ectopic expression of Bmi-1 in NHOK (HOK/Bmi-1) decreased the level of intracellular and secreted TGF-{beta}1 induced dephosphorylation of Smad2/3, and diminished the level of p15{sup INK4B} and p57{sup KIP2}. Moreover, Bmi-1 expression led to the inhibition of TGF-{beta}-responsive promoter activity in a dose-specific manner. Knockdown of Bmi-1 in rapidly proliferating HOK/Bmi-1 and cancer cells increased the level of phosphorylated Smad2/3, p15{sup INK4B}, and p57{sup KIP2}. In addition, an exposure of senescent NHOK to TGF-{beta} receptor I kinase inhibitor or anti-TGF-{beta} antibody resulted in enhanced replicative potential of cells. Taken together, these data suggest that Bmi-1 suppresses senescence of cells by inhibiting the TGF-{beta} signaling pathway in NHOK.

  17. Feasible way of Human Solid and Liquid Wastes' Inclusion Into Intersystem Mass Exchange of Biological-Technical Life Support Systems (United States)

    Ushakova, Sofya; Tikhomirov, Alexander A.; Tikhomirova, Natalia; Kudenko, Yurii; Griboskaya, Illiada; Gros, Jean-Bernard; Lasseur, Christophe

    The basic objective arising at use of mineralized human solid and liquid wastes serving as the source of mineral elements for plants cultivation in biological-technical life support systems appears to be NaCl presence in them. The given work is aimed at feasibility study of mineralized human metabolites' utilization for nutrient solutions' preparation for their further employment at a long-term cultivation of uneven-aged wheat and Salicornia europaea L. cenosis in a conveyer regime. Human solid and liquid wastes were mineralized by the "wet incineration" method developed by Yu. Kudenko. On their base the solutions were prepared which were used for cultivation of 5-aged wheat conveyer with the time step-interval of 14 days. Wheat was cultivated by hydroponics method on expanded clay aggregate. For partial demineralization of nutrient solution every two weeks after regular wheat harvesting 12 L of solution was withdrawn from the wheat irrigation tank and used for Salicornia europaea cultivation by the water culture method in a conveyer regime. The Salicornia europaea conveyer was represented by 2 ages with the time step-interval of 14 days. Resulting from repeating withdrawal of the solution used for wheat cultivation, sodium concentration in the wheat irrigation solution did not exceed 400 mg/l, and mineral elements contained in the taken solution were used for Salicornia europaea cultivation. The experiment lasted 7 months. Total wheat biomass productivity averaged 30.1 g*m-2*day-1 at harvest index equal to 36.8The work was carried out under support of SB RAS grant 132 and INTAS 05-1000008-8010

  18. From Beginning to End: How Engineering Students Think and Talk about Sustainability across the Life Cycle. Research Brief (United States)

    Kilgore, Deborah; Jocuns, Andrew; Yasuhara, Ken; Atman, Cynthia J.


    The Academic Pathways Study (APS) is a multi-institution, mixed-methods, longitudinal study which examines engineering students' learning and development as they move into, through, and beyond their undergraduate institutions (Atman et al., 2008; Sheppard et al., 2004). It is part of the Center for the Advancement of Engineering Education…

  19. Comparison of the Life Cycles of Genetically Distant Species C and Species D Human Adenoviruses Ad6 and Ad26 in Human Cells (United States)

    Turner, Mallory A.; Middha, Sumit; Hofherr, Sean E.


    ABSTRACT Our understanding of adenovirus (Ad) biology is largely extrapolated from human species C Ad5. Most humans are immune to Ad5, so lower-seroprevalence viruses like human Ad6 and Ad26 are being tested as therapeutic vectors. Ad6 and Ad26 differ at the DNA level by 34%. To better understand how this might impact their biology, we examined the life cycle of the two viruses in human lung cells in vitro. Both viruses infected A549 cells with similar efficiencies, executed DNA replication with identical kinetics within 12 h, and began killing cells within 72 h. While Ad6-infected cells remained adherent until death, Ad26-infected cells detached within 12 h of infection but remained viable. Next-generation sequencing (NGS) of mRNA from infected cells demonstrated that viral transcripts constituted 1% of cellular mRNAs within 6 h and 8 to 16% within 12 h. Quantitative PCR and NGS revealed the activation of key early genes at 6 h and transition to late gene activation by 12 h by both viruses. There were marked differences in the balance of E1A and E1B activation by the two viruses and in the expression of E3 immune evasion mRNAs. Ad6 was markedly more effective at suppressing major histocompatibility complex class I (MHC I) display on the cell surface and in evading TRAIL-mediated apoptosis than was Ad26. These data demonstrate shared as well as divergent life cycles in these genetically distant human adenoviruses. An understanding of these differences expands the knowledge of alternative Ad species and may inform the selection of related Ads for therapeutic development. IMPORTANCE A burgeoning number of adenoviruses (Ads) are being harnessed as therapeutics, yet the biology of these viruses is generally extrapolated from Ad2 and Ad5. Here, we are the first to compare the transcriptional programs of two genetically distant Ads by mRNA next-generation sequencing (NGS). Species C Ad6 and Ad26 are being pursued as lower-seroprevalence Ad vectors but differ at the DNA

  20. Context of the beginning of tobacco use in different social groups. (United States)

    Panaino, Edina Ferreira; Soares, Cássia Baldini; Campos, Célia Maria Sivalli


    analyze contextual aspects of the beginning of tobacco use in different social groups, from everyday representations about the act of smoking. five focus groups were conducted to promote discussion about the context of beginning of tobacco use, with groups of people who represented different patterns of social reproduction. The data analysis was based on the theory of social representations, which contextualizes how each group presents the tobacco consumption. the contexts of the beginning of tobacco use were diverse, according to patterns of social reproduction; there were common representations to all groups, but there were also unique representations of each social group. Tobacco is represented as indispensable for groups in unstable social reproduction situations, and as an instrument of pleasure and stress relief for those who can access other material assets. the study contributed to exposing the concepts on tobacco consumption that are socially disseminated, which can serve as an instrument to planning programs and health actions.

  1. Selection on alleles affecting human longevity and late-life disease: the example of apolipoprotein E.

    Directory of Open Access Journals (Sweden)

    Fotios Drenos


    Full Text Available It is often claimed that genes affecting health in old age, such as cardiovascular and Alzheimer diseases, are beyond the reach of natural selection. We show in a simulation study based on known genetic (apolipoprotein E and non-genetic risk factors (gender, diet, smoking, alcohol, exercise that, because there is a statistical distribution of ages at which these genes exert their influence on morbidity and mortality, the effects of selection are in fact non-negligible. A gradual increase with each generation of the epsilon2 and epsilon3 alleles of the gene at the expense of the epsilon4 allele was predicted from the model. The epsilon2 allele frequency was found to increase slightly more rapidly than that for epsilon3, although there was no statistically significant difference between the two. Our result may explain the recent evolutionary history of the epsilon 2, 3 and 4 alleles of the apolipoprotein E gene and has wider relevance for genes affecting human longevity.

  2. Colonization and Succession within the Human Gut Microbiome by Archaea, Bacteria, and Microeukaryotes during the First Year of Life

    Directory of Open Access Journals (Sweden)

    Paul Wilmes


    Full Text Available Perturbations to the colonization process of the human gastrointestinal tract have been suggested to result in adverse health effects later in life. Although much research has been performed on bacterial colonization and succession, much less is known about the other two domains of life, archaea, and eukaryotes. Here we describe colonization and succession by bacteria, archaea and microeukaryotes during the first year of life (samples collected around days 1, 3, 5, 28, 150, and 365 within the gastrointestinal tract of infants delivered either vaginally or by cesarean section and using a combination of quantitative real-time PCR as well as 16S and 18S rRNA gene amplicon sequencing. Sequences from organisms belonging to all three domains of life were detectable in all of the collected meconium samples. The microeukaryotic community composition fluctuated strongly over time and early diversification was delayed in infants receiving formula milk. Cesarean section-delivered (CSD infants experienced a delay in colonization and succession, which was observed for all three domains of life. Shifts in prokaryotic succession in CSD infants compared to vaginally delivered (VD infants were apparent as early as days 3 and 5, which were characterized by increased relative abundances of the genera Streptococcus and Staphylococcus, and a decrease in relative abundance for the genera Bifidobacterium and Bacteroides. Generally, a depletion in Bacteroidetes was detected as early as day 5 postpartum in CSD infants, causing a significantly increased Firmicutes/Bacteroidetes ratio between days 5 and 150 when compared to VD infants. Although the delivery mode appeared to have the strongest influence on differences between the infants, other factors such as a younger gestational age or maternal antibiotics intake likely contributed to the observed patterns as well. Our findings complement previous observations of a delay in colonization and succession of CSD infants

  3. Bacteriophages in the human gut: Our fellow travelers throughout life and potential biomarkers of heath or disease. (United States)

    Bakhshinejad, Babak; Ghiasvand, Saeedeh


    The gastrointestinal (GI) tract is populated by a huge variety of viruses. Bacterial viruses (bacteriophages) constitute the largest and the most unrecognized part of virome. The total bacteriophage community of the human gut is called phageome. Phages colonize the gut from the earliest moments of life and become our fellow travelers throughout life. Phageome seems to be unique to each individual and shows a high degree of interpersonal variation. In the healthy gut, a vast majority of phages have a lysogenic lifestyle. These prophages serve as a major respository of mobile genetic elements in the gut and play key roles in the exchange of genetic material between bacterial species via horizontal gene transfer (HGT). But, imbalance in the gut microbial community during dysbiosis, caused by diseases or environmental stresses such as antibiotics, is accompanied by induction of prophages leading to a decreased ratio of symbionts to pathobionts. Based on this, a diseased gut is transformed from an environment predominantly occupied by prophages to an ecosystem mostly inhabited by lytic phages. A growing body of evidence has provided support for the notion that phageome structure and composition change dependent on the physiological or pathological status of the body. This has been demonstrated by pronounced quantitative and qualitative differences between the phageome of healthy individuals and patients. Although many aspects of the contribution made by phages to human biology remain to be understood, recent findings favor the suggestion that phageome might represent potential to serve as a biomarker of health or disease. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. Comparison of patterns of use, beliefs, and attitudes related to waterpipe between beginning and established smokers. (United States)

    Asfar, Taghrid; Ward, Kenneth D; Eissenberg, Thomas; Maziak, Wasim


    To compare patterns of use, beliefs, and attitudes related to waterpipe smoking between university students (beginning smokers) and cafe customers (established smokers) in Aleppo Syria, in order to explore the evolution of this smoking method. Two cross-sectional surveys were conducted among representative samples of university students (total 587, 48.4% men, mean age 22 years), and waterpipe users among cafe' customers (total 268, 60% men, mean age 30 years) in Aleppo, Syria. We used interviewer-administered questionnaire inquiring about pattern of waterpipe smoking (initiation, frequency), situational characteristics of use (partner, place, sharing), beliefs related to waterpipe smoking (harmful/addictive properties of waterpipe), attitudes related to waterpipe smoking (confidence in quitting, will to quit, motivation for quitting, past year quit attempt), and cigarette smoking. Daily and regular patterns of smoking become more prevalent with increased duration of smoking, but intermittent smoking remains the predominant pattern of waterpipe use. Women seem to be drawn later to the habit, which seem to escape the usual taboo against women's cigarette smoking. Patterns and context of waterpipe use tend to change with progress of the practice affecting frequency, setting, and sharing of waterpipe. Unlike beginners, established waterpipe smokers seem more smoking-method oriented, more hooked on the habit, less willing to quit, and less likely to foresee challenges to quitting. Use patterns and attitudes related to waterpipe smoking evolve to accommodate the change in dependence and life circumstances of the smoker. Most of use features, beliefs, attitudes, as well as time-course seem unique to this smoking method requiring novel approach to intervention.

  5. Conditional reprogramming of pediatric airway epithelial cells: A new human model to investigate early-life respiratory disorders. (United States)

    Wolf, S; Perez, G F; Mukharesh, L; Isaza, N; Preciado, D; Freishtat, R J; Pillai, D; Rose, M C; Nino, G


    Airway epithelial cells (AEC) are quite difficult to access in newborns and infants. It is critically important to develop robust life-extended models to conduct translational studies in this age group. We propose the use of a recently described cell culture technology (conditionally reprogrammed cells-CRC) to generate continuous primary cell cultures from nasal and bronchial AEC of young children. We collected nasal and/or bronchial AEC from a total of 23 subjects of different ages including newborns/infants/toddlers (0-2 years; N = 9), school-age children (4-11 years; N = 6), and a group of adolescent/adult donors (N = 8). For CRC generation, we used conditioned medium from mitotically inactivated 3T3 fibroblasts and Rho-associated kinase (ROCK) inhibitor (Y-27632). Antiviral immune responses were studied using 25 key antiviral genes and protein production of type III epithelial interferon (IFN λ1) after double-stranded (ds) RNA exposure. CRC derived from primary AEC of neonates/infants and young children exhibited: (i) augmented proliferative capacity and life extension, (ii) preserved airway epithelial phenotype after multiple passages, (iii) robust immune responses characterized by the expression of innate antiviral genes and parallel nasal/bronchial production of IFN λ1 after exposure to dsRNA, and (iv) induction of airway epithelial inflammatory and remodeling responses to dsRNA (eg, CXCL8 and MMP9). Conditional reprogramming of AEC from young children is a feasible and powerful translational approach to investigate early-life airway epithelial immune responses in humans. © 2017 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.

  6. The End Is the Beginning: Parkinson’s Disease in the Light of Brain Imaging

    Directory of Open Access Journals (Sweden)

    Arianna Bellucci


    Full Text Available Parkinson’s disease (PD, the most common neurodegenerative disorder, is characterized by abnormal accumulation of α-synuclein aggregates known as Lewy bodies (LB and loss of nigrostriatal dopaminergic neurons. Recent neuroimaging studies suggest that in the early phases of PD, synaptic and axonal damage anticipate the onset of a frank neuronal death. Paralleling, even post mortem studies on the brain of affected patients and on animal models support that synapses might represent the primary sites of functional and pathological changes. Indeed, α-synuclein microaggregation and spreading at terminals, by dysregulating the synaptic junction, would block neurotransmitter release, thus triggering a retrograde neurodegenerative process ending with neuronal cell loss by proceeding through the axons. Rather than neurodegeneration, loss of dopaminergic neuronal endings and axons could thus underlie the onset of connectome dysfunction and symptoms in PD and parkinsonisms. However, the manifold biases deriving from the interpretation of human brain imaging data hinder the validation of this hypothesis. Here, we present pivotal evidence supporting that novel comparative brain imaging studies, in patients and experimental models of PD in preliminary stages of disease, could be instrumental for proving whether synaptic endings are the sites where degeneration begins and initiating the factual achievement of disease modifying approaches. The need for such investigations is timely to define an early therapeutic window of intervention to attempt disease halting by terminal and/or axonal healing.

  7. Methodologically Sound: Evaluating the Psychometric Approach to the Assessment of Human Life History [Reply to Copping, Campbell, and Muncer, 2014 (United States)

    Cabeza de Baca, Tomás; Black, Candace Jasmine; García, Rafael Antonio; Fernandes, Heitor Barcellos Ferreira; Wolf, Pedro Sofio Abril; Woodley of Menie, Michael Anthony


    Copping, Campbell, and Muncer (2014) have recently published an article critical of the psychometric approach to the assessment of life history (LH) strategy. Their purported goal was testing for the convergent validation and examining the psychometric structure of the High-K Strategy Scale (HKSS). As much of the literature on the psychometrics of human LH during the past decade or so has emanated from our research laboratory and those of close collaborators, we have prepared this detailed response. Our response is organized into four main sections: (1) A review of psychometric methods for the assessment of human LH strategy, expounding upon the essence of our approach; (2) our theoretical/conceptual concerns regarding the critique, addressing the broader issues raised by the critique regarding the latent and hierarchical structure of LH strategy; (3) our statistical/methodological concerns regarding the critique, examining the validity and persuasiveness of the empirical case made specifically against the HKSS; and (4) our recommendations for future research that we think might be helpful in closing the gap between the psychometric and biometric approaches to measurement in this area. Clearly stating our theoretical positions, describing our existing body of work, and acknowledgintheir limitations should assist future researchers in planning and implementing more informed and prudent empirical research that will synthesize the psychometric approach to the assessment of LH strategy with complementary methods. PMID:25844774

  8. Life sentence penalty and extradition under article 3 of the ECHR: A leading case of the European Court of Human Rights

    Directory of Open Access Journals (Sweden)

    Dr.Sc. Mario Antinucci


    Full Text Available Life sentence penalty covers a diverse range of practices, from the most severe form of life imprisonment without parole, in which a person is sentenced to die in prison so long as their sentence stands, to more indeterminate sentences in which at the time of sentencing it is not clear how long the sentenced person will spend in prison. Dealing with the question whether the extradition of a person to a foreign state where is accused of a crime for which a sentence of life imprisonment can be imposed can potentially violate article 3 of the European Convention on Human Rights. What all these sentences have in common, however, is that at the time the sentence is passed, a person is liable to be detained for the rest of his or her natural life. We all know “The United Nations Standard Minimum Rules” and relevant international instruments on the rehabilitation of imprisonment, but at the moment more than 73 States in the world retain life imprisonment as a penalty for offences committed while under the age of 18. General perspective of criminal justice reform in Latin America should take into a right account the meaning of life - imprisonment penalty under article 3 of the European Convention on Human Rights, which prohibits torture and inhuman or degrading treatment or punishment.

  9. Examining factors affecting beginning teachers’ transfer of learning of ICT-enhanced learning activities in their teaching practice

    NARCIS (Netherlands)

    Voogt, Joke; Agyei, Douglas; McBride, Ron; Searson, Michael


    This study examined 100 beginning teachers’ transfer of learning in utilizing Information Communication Technology-enhanced activity-based learning activities. The beginning teachers had participated in a professional development program characterized by ‘learning technology by collaborative design’

  10. Examining factors affecting beginning teachers' transfer of learning of ICT-enhanced learning activities in their teaching practice

    NARCIS (Netherlands)

    Agyei, D.D.; Voogt, J.


    This study examined 100 beginning teachers’ transfer of learning when utilising Information Communication Technology-enhanced activity-based learning activities. The beginning teachers had participated in a professional development program that was characterised by ‘learning technology by

  11. High early life mortality in free-ranging dogs is largely influenced by humans


    Manabi Paul; Sreejani Sen Majumder; Shubhra Sau; Anjan K. Nandi; Anindita Bhadra


    Free-ranging dogs are a ubiquitous part of human habitations in many developing countries, leading a life of scavengers dependent on human wastes for survival. The effective management of free-ranging dogs calls for understanding of their population dynamics. Life expectancy at birth and early life mortality are important factors that shape life-histories of mammals. We carried out a five year-long census based study in seven locations of West Bengal, India, to understand the pattern of popul...

  12. Beginning Drupal

    CERN Document Server

    Redding, Jacob


    A thorough introduction that lessens the learning curve to Drupal development. Drupal is a free, open source modular framework and content management system written in the programming language PHP that carries with it a reputation of a steep learning curve. This guide to Drupal methodically demystifies Drupal and even aims shorten the learning curve. Author Jacob Redding is deeply embedded in the Drupal community, and walks first-time Drupal developers through the installation and configuration of a Drupal system. In-depth information on key areas of Drupal explore the Drupal hook system, Drup

  13. Border Cave and the beginning of the Later Stone Age in South Africa. (United States)

    Villa, Paola; Soriano, Sylvain; Tsanova, Tsenka; Degano, Ilaria; Higham, Thomas F G; d'Errico, Francesco; Backwell, Lucinda; Lucejko, Jeannette J; Colombini, Maria Perla; Beaumont, Peter B


    The transition from the Middle Stone Age (MSA) to the Later Stone Age (LSA) in South Africa was not associated with the appearance of anatomically modern humans and the extinction of Neandertals, as in the Middle to Upper Paleolithic transition in Western Europe. It has therefore attracted less attention, yet it provides insights into patterns of technological evolution not associated with a new hominin. Data from Border Cave (KwaZulu-Natal) show a strong pattern of technological change at approximately 44-42 ka cal BP, marked by adoption of techniques and materials that were present but scarcely used in the previous MSA, and some novelties. The agent of change was neither a revolution nor the advent of a new species of human. Although most evident in personal ornaments and symbolic markings, the change from one way of living to another was not restricted to aesthetics. Our analysis shows that: (i) at Border Cave two assemblages, dated to 45-49 and >49 ka, show a gradual abandonment of the technology and tool types of the post-Howiesons Poort period and can be considered transitional industries; (ii) the 44-42 ka cal BP assemblages are based on an expedient technology dominated by bipolar knapping, with microliths hafted with pitch from Podocarpus bark, worked suid tusks, ostrich eggshell beads, bone arrowheads, engraved bones, bored stones, and digging sticks; (iii) these assemblages mark the beginning of the LSA in South Africa; (iv) the LSA emerged by internal evolution; and (v) the process of change began sometime after 56 ka.

  14. Inhibitory effects of (-)-epigallocatechin gallate on the life cycle of human immunodeficiency virus type 1 (HIV-1). (United States)

    Yamaguchi, Koushi; Honda, Mitsuo; Ikigai, Hajime; Hara, Yukihiko; Shimamura, Tadakatsu


    Epigallocatechin gallate (EGCg), the major tea catechin, is known as a potent anti-bacterial agent. In addition, anti-tumor promoting, anti-inflammatory, anti-oxidative and antiviral activities have been reported. In the present study, we investigated possible anti-human immunodeficiency virus type-1 (HIV-1) activity of EGCg and its mechanisms of action in the viral life cycle. EGCg impinges on each step of the HIV life cycle. Thus, destruction of the viral particles, viral attachment to cells, post-adsorption entry into cells, reverse transcription (RT), viral production from chronically-infected cells, and the level of expression of viral mRNA, were analyzed using T-lymphoid (H9) and monocytoid (THP-1) cell systems, and antiviral protease activity was measured using a cell-free assay. Inhibitory effects of EGCg on specific binding of the virions to the cellular surfaces and changes in the steady state viral regulation (mRNA expression) due to EGCg were not observed. However, EGCg had a destructive effect on the viral particles, and post-adsorption entry and RT in acutely infected monocytoid cells were significantly inhibited at concentrations of EGCg greater than 1 microM, and protease kinetics were suppressed at a concentration higher than 10 microM in the cell-free study. Viral production by THP-1 cells chronically-infected with HIV-1 was also inhibited in a dose-dependent manner and the inhibitory effect was enhanced by liposome modification of EGCg. As expected, increased viral mRNA production was observed in lipopolysaccharide (LPS)-activated chronically HIV-1-infected cells. This production was significantly inhibited by EGCg treatment of THP-1 cells. In contrast, production of HIV-1 viral mRNA in unstimulated or LPS-stimulated T-lymphoid cells (H9) was not inhibited by EGCg. Anti-HIV viral activity of EGCg may thus result from an interaction with several steps in the HIV-1 life cycle.

  15. The Impact of Professional Development on Beginning Teachers’ Practices in One Secondary School

    Directory of Open Access Journals (Sweden)

    Marjorie Hinds


    Full Text Available A case study was conducted in 2004-2005 on the professional development experiences of beginning teachers (1-5 years of experience in an Ontario, Canada secondary school (Grades 7-12 and the impact of those experiences in improving their practices. For comparative purposes, the study included the perspectives of administrators from the same school on the impact of professional development on these teachers. The findings revealed that the literacy training program was successfully implemented at the school and positively affected beginning teachers’ knowledge, instructional strategies, and planning practices. Other findings indicated that beginning teachers needed subject content and instructional strategies, ongoing mentoring, and skills in both classroom management and mapping the curriculum. Based on the findings of the study, a new framework for professional development is suggested. A number of recommendations propose ways of connecting research, policy and practice that could ultimately improve the effectiveness of professional development programs for beginning teachers.   Key words: teacher professional development, beginning teacher, adult learning, self-efficacy, collective efficacy, supervision, organizational policies and culture

  16. Houttuynia cordata targets the beginning stage of herpes simplex virus infection.

    Directory of Open Access Journals (Sweden)

    Pei-Yun Hung

    Full Text Available Herpes simplex virus (HSV, a common latent virus in humans, causes certain severe diseases. Extensive use of acyclovir (ACV results in the development of drug-resistant HSV strains, hence, there is an urgent need to develop new drugs to treat HSV infection. Houttuynia cordata (H. cordata, a natural herbal medicine, has been reported to exhibit anti-HSV effects which is partly NF-κB-dependent. However, the molecular mechanisms by which H. cordata inhibits HSV infection are not elucidated thoroughly. Here, we report that H. cordata water extracts (HCWEs inhibit the infection of HSV-1, HSV-2, and acyclovir-resistant HSV-1 mainly via blocking viral binding and penetration in the beginning of infection. HCWEs also suppress HSV replication. Furthermore, HCWEs attenuate the first-wave of NF-κB activation, which is essential for viral gene expressions. Further analysis of six compounds in HCWEs revealed that quercetin and isoquercitrin inhibit NF-κB activation and additionally, quercetin also has an inhibitory effect on viral entry. These results indicate that HCWEs can inhibit HSV infection through multiple mechanisms and could be a potential lead for development of new drugs for treating HSV.

  17. [The Problem of Beginning of the Personal Being In the Anthropology of V. E. Frankl]. (United States)

    Sellés Dauder, Juan Fernando


    In this paper we review the V. E. Frankl' conception of the 'person', which he understands as the superior part in man. This study consists of three parts: a) In the first we study 10 thesis that the father of logotherapy offers on the person, namely: 1st) the person is an individual; 2nd) whitaut possibility of sum; 3rd) is a new being; 4th) is spiritual; 5th) is existential; 6th) is the 'I' or the 'ego'; 7th) provides unity and wholeness; 8th) is dynamic; 9th) is able to transcend and to face herself; 10th) He is not understood by itself but from the point of view of transcendence. b) In the second part are studied 7 synonyms that the founder of the third Viennese school of psychology offers on the person: 1st) individual; 2nd) I; 3rd) personality; 4th) existence; 5th) spirit; 6th) heart; 7th) becoming. c) The third part we review the franklian hypothesis defending that the human person appears after the birth of human biological life. Although it is the third part that gives the the title of this work, it can only be understood, and also reviewed, after having founded in the preceding two parties what specifically understand V.E. Frankl for person.

  18. A curated transcriptome dataset collection to investigate the functional programming of human hematopoietic cells in early life. (United States)

    Rahman, Mahbuba; Boughorbel, Sabri; Presnell, Scott; Quinn, Charlie; Cugno, Chiara; Chaussabel, Damien; Marr, Nico


    Compendia of large-scale datasets made available in public repositories provide an opportunity to identify and fill gaps in biomedical knowledge. But first, these data need to be made readily accessible to research investigators for interpretation. Here we make available a collection of transcriptome datasets to investigate the functional programming of human hematopoietic cells in early life. Thirty two datasets were retrieved from the NCBI Gene Expression Omnibus (GEO) and loaded in a custom web application called the Gene Expression Browser (GXB), which was designed for interactive query and visualization of integrated large-scale data. Quality control checks were performed. Multiple sample groupings and gene rank lists were created allowing users to reveal age-related differences in transcriptome profiles, changes in the gene expression of neonatal hematopoietic cells to a variety of immune stimulators and modulators, as well as during cell differentiation. Available demographic, clinical, and cell phenotypic information can be overlaid with the gene expression data and used to sort samples. Web links to customized graphical views can be generated and subsequently inserted in manuscripts to report novel findings. GXB also enables browsing of a single gene across projects, thereby providing new perspectives on age- and developmental stage-specific expression of a given gene across the human hematopoietic system. This dataset collection is available at:

  19. Associations between human milk oligosaccharides and infant body composition in the first 6 mo of life. (United States)

    Alderete, Tanya L; Autran, Chloe; Brekke, Benjamin E; Knight, Rob; Bode, Lars; Goran, Michael I; Fields, David A


    Evidence linking breastfeeding to reduced risk of developing childhood obesity is inconclusive, yet previous studies have not considered variation in specific components of breast milk that may affect early development. We examined whether differences in the composition of human milk oligosaccharides (HMOs) correlate with infant growth and body composition at 1 and 6 mo of age. Twenty-five mother-infant dyads were recruited from the University Hospital at the University of Oklahoma Health Sciences Center. Infants were breastfed for 6 mo. Breast-milk and infant measures were obtained at 1 and 6 mo of infant age. HMO composition was analyzed by high-pressure liquid chromatography, and infant growth (length and weight) and body composition (percentage fat, total fat, lean mass) were measured by dual-energy X-ray absorptiometry. Relations between HMOs and infant growth and body composition were examined by using multiple linear regression. A priori covariates included maternal prepregnancy body mass index, pregnancy weight gain, and infant age and sex. Higher HMO diversity and evenness at 1 mo were associated with lower total and percentage fat mass at 1 mo. At 1 mo, each 1-μg/mL increase in lacto-N-fucopentaose (LNFP) I was associated with a 0.40-kg lower infant weight (P = 0.03). At 6 mo, each 1-μg/mL increase in LNFPI was associated with a 1.11-kg lower weight (P = 0.03) and a 0.85-g lower lean mass (P = 0.01). At 6 mo, each 1-μg/mL increase in LNFPI was associated with a 0.79-g lower fat mass (P = 0.02), whereas disialyl-lacto-N-tetraose and LNFPII were associated with a 1.92-g (P = 0.02) and 0.42-g (P = 0.02) greater fat mass, respectively. At 6 mo, each 1-μg/mL increase in fucosyl-disialyl-lacto-N-hexaose and lacto-N-neotetraose was associated with 0.04% higher (P = 0.03) and 0.03% lower (P body fat, respectively. These findings support the hypothesis that differences in HMO composition in mother's milk are associated with infant growth and body composition

  20. The "Reluctant" State and the Beginning of the End of State Education (United States)

    Ball, Stephen J.


    This paper argues that English education policy has come full-circle--from the first constitution of a state system of education in 1870 to the beginning of the end of state education in 2010--and that this circularity can be understood in relation to the reluctant state. That is, in the nineteenth century, the English state hesitantly and slowly…

  1. Enumeration of Mars years and seasons since the beginning of telescopic exploration (United States)

    Piqueux, Sylvain; Byrne, Shane; Titus, Timothy N.; Hansen, Candice J.; Kieffer, Hugh H.


    A clarification for the enumeration of Mars Years prior to 1955 is presented, along with a table providing the Julian dates associated with Ls = 0° for Mars Years -183 (beginning of the telescopic study of Mars) to 100. A practical algorithm for computing Ls as a function of the Julian Date is provided. No new science results are presented

  2. Flood hazard, vulnerability, and risk assessment for human life (United States)

    Pan, T.; Chang, T.; Lai, J.; Hsieh, M.; Tan, Y.; Lin, Y.


    Flood risk assessment is an important issue for the countries suffering tropical cyclones and monsoon. Taiwan is located in the hot zone of typhoon tracks in the Western Pacific. There are three to five typhoons landing Taiwan every year. Typhoons and heavy rainfalls often cause inundation disaster rising with the increase of population and the development of social economy. The purpose of this study is to carry out the flood hazard, vulnerability and risk in term of human life. Based on the concept that flood risk is composed by flood hazard and vulnerability, a inundation simulation is performed to evaluate the factors of flood hazard for human life according to base flood (100-year return period). The flood depth, velocity and rising ratio are the three factors of flood hazards. Furthermore, the factors of flood vulnerability are identified in terms of human life that are classified into two main factors, residents and environment. The sub factors related to residents are the density of population and the density of vulnerable people including elders, youngers and disabled persons. The sub factors related to environment include the the number of building floors, the locations of buildings, the and distance to rescue center. The analytic hierarchy process (AHP) is adopted to determine the weights of these factors. The risk matrix is applied to show the risk from low to high based on the evaluation of flood hazards and vulnerabilities. The Tseng-Wen River watershed is selected as the case study because a serious flood was induced by Typhoon Morakot in 2009, which produced a record-breaking rainfall of 2.361mm in 48 hours in the last 50 years. The results of assessing the flood hazard, vulnerability and risk in term of human life could improve the emergency operation for flood disaster to prepare enough relief goods and materials during typhoon landing.

  3. Aspiring Principals' Perception of the Challenges of Beginning Principals and the Support That They Need (United States)

    Ng, Pak Tee


    This paper presents the results of an exploratory research project about the perception of aspiring principals regarding the challenges of beginning principals and the support that they need. These aspiring principals are participants on the Leaders in Education Programme (LEP) in Singapore. According to the research findings, the LEP participants…

  4. Effects of Conducting Instruction on the Musical Performance of Beginning Band Students. (United States)

    Kelly, Steven N.


    Investigates the effects of conducting instruction on beginning band students' individual rhythmic performance, group rhythmic performance, group performance of legato and staccato, and group performance of phrasing and dynamics. The students represented diverse ethnic and cultural backgrounds. Concludes the conducting instruction is a useful tool…

  5. A Pilot Study of Problems and Practices in the Induction of Beginning Teachers. (United States)

    Bouchard, John B.; Hull, Ronald E.

    A pilot study was designed to test the practicality of gathering data through interviews and to provide tentative information on induction problems and practices encountered by beginning teachers in the Cattaraugus-Chautauqua County area of New York. Fifty-three elementary self-contained classroom teachers and secondary academic subject-matter…

  6. Modelling Beginning Teachers' Assessment Literacy: The Contribution of Training, Self-Efficacy, and Conceptions of Assessment (United States)

    Levy-Vered, Adi; Alhija, Fadia Nasser-Abu


    Teachers devote a substantial amount of their time to assessment-related activities. This study aimed to describe beginning teachers' assessment literacy and to examine a structural model that binds assessment literacy with assessment training, self-efficacy, and conceptions of assessment. Data were collected from 327 Israeli inductee teachers and…


    Directory of Open Access Journals (Sweden)

    BARSAN Lucian


    Full Text Available The paper presents some considerations about the necessity of evaluating the environmental impact of a product during its entire life. The present situation (economic, social and ecologic imposes solutions to reduce this impact as a result of an analysis performed during all stages of the life cycle. This paper focuses on design solutions with consequences in the last stage, the end-of-life. Reusing products, with, or without remanufacturing and recycling the materials from products that cannot be reused represent some options analysed in this paper. The end-of-life options should be known even from the beginning of the design process and should be included as design objectives or, at least as constrictions. Considering them as human needs would naturally include them in the requirements list.

  8. The Role of Perception, Interpretation, and Decision Making in the Development of Beginning Teachers' Competence (United States)

    Santagata, Rossella; Yeh, Cathery


    This study investigates beginning US elementary teachers' competence for teaching mathematics and its development during teacher preparation and into the first 2 years of full-time teaching. Data are drawn from three longitudinal case studies and include the classroom video analysis survey, classroom observations and interviews about teachers'…

  9. The Role of Genre in Reflective Practice: Tracing the Development of a Beginning Teacher's Journaling Practice (United States)

    Hallman, Heidi; Adam, Amy Rousselo


    In this article, a teacher educator and a first-year teacher identify the role that genre, in a rhetorical sense, plays in reflective practice. As reflection in teacher education has been criticized for its potential to reinforce prior attitudes and dispositions within pre-service and beginning teachers, we see how meta-knowledge of genre is…

  10. Longitudinal Effects of Induction on Teaching Skills and Attrition Rates of Beginning Teachers (United States)

    Helms-Lorenz, Michelle; van de Grift, Wim; Maulana, Ridwan


    The teaching profession faces a shortage as well as a decline of teaching skills. A possible way to mitigate this is to implement evidence-based induction arrangements. Seventy-one schools with 338 beginning secondary education teachers were randomly allocated to an experimental or a control group. The experimental schools used induction…

  11. Longitudinal effects of induction on teaching skills and attrition rates of beginning teacher

    NARCIS (Netherlands)

    Helms-Lorenz, Michelle; van de Grift, Wim; Maulana, Ridwan

    The teaching profession faces a shortage as well as a decline of teaching skills. A possible way to mitigate this is to implement evidence-based induction arrangements. Seventy-one schools with 338 beginning secondary education teachers were randomly allocated to an experimental or a control group.

  12. Life Complexity and Diversity

    Indian Academy of Sciences (India)

    It is as if the stage is cleared from time to time to make for fresh beginnings, with major bouts of extinction. Humans are amongst the most complex products of evolution having in turn populated the world with ever growing numbers of complex artefacts. These artefacts are now threatening to overwhelm the diversity of life.

  13. Evolution, human-microbe interactions, and life history plasticity. (United States)

    Rook, Graham; Bäckhed, Fredrik; Levin, Bruce R; McFall-Ngai, Margaret J; McLean, Angela R


    A bacterium was once a component of the ancestor of all eukaryotic cells, and much of the human genome originated in microorganisms. Today, all vertebrates harbour large communities of microorganisms (microbiota), particularly in the gut, and at least 20% of the small molecules in human blood are products of the microbiota. Changing human lifestyles and medical practices are disturbing the content and diversity of the microbiota, while simultaneously reducing our exposures to the so-called old infections and to organisms from the natural environment with which human beings co-evolved. Meanwhile, population growth is increasing the exposure of human beings to novel pathogens, particularly the crowd infections that were not part of our evolutionary history. Thus some microbes have co-evolved with human beings and play crucial roles in our physiology and metabolism, whereas others are entirely intrusive. Human metabolism is therefore a tug-of-war between managing beneficial microbes, excluding detrimental ones, and channelling as much energy as is available into other essential functions (eg, growth, maintenance, reproduction). This tug-of-war shapes the passage of each individual through life history decision nodes (eg, how fast to grow, when to mature, and how long to live). Copyright © 2017 Elsevier Ltd. All rights reserved.

  14. Implementation of humanistic ideas in philosophy of Education in the beginning of XX century

    Directory of Open Access Journals (Sweden)

    Tyrsyjanova R.K.


    Full Text Available In the beginning of the XX century European school-teaching practice needs radical changes, the traditional school of study has been heavily criticized, needed reforms. Philosophy of education of that time provided in this article by the creative work of prominent reformers – humanists had actual implementation in teaching practice in the form of school coomunity of John Dewey and Summerhill-school of Alexander Neill.

  15. Implementation of humanistic ideas in philosophy of Education in the beginning of XX century


    Tyrsyjanova R.K.


    In the beginning of the XX century European school-teaching practice needs radical changes, the traditional school of study has been heavily criticized, needed reforms. Philosophy of education of that time provided in this article by the creative work of prominent reformers – humanists had actual implementation in teaching practice in the form of school coomunity of John Dewey and Summerhill-school of Alexander Neill.

  16. A conception of modern Life as “the Awakening of the Human Spirit, revisited”

    DEFF Research Database (Denmark)

    Brock, Steen


    By reference to Stanley Cavell´s characterization of the later Wittgenstein´s writings as expressing a “philosophy of culture”, it is argued that this characterization also might cast a light on Wittgenstein´s early remarks on Frazer In relation to this I show that three aspects in conjunction of...

  17. Aspects from the biography of Professor Cornel Tiberiu Opriş. The Beginnings. (United States)

    Rotaru, Alexandru


    Professor Cornel Tiberiu Opriş was the founder of the clinic for Oral and Maxillofacial Surgery, and also the first to teach this specialty in Cluj-Napoca in the first half of the twentieth century. Earlier in his profession, Dr. Cornel Opriş went from research into human physiology to practical activity in the field of surgery, to which he was more attracted. He was active both in research and Oral and Maxillofacial plastic surgery, facing unfavorable material and social conditions, exacerbated by the circumstances of war and the relocation of the Faculty of Medicine to Sibiu. This article presents the life and work of Prof. Dr. Cornel Opris, with particular reference to the stage of education, the problems associated with "family, society and school."

  18. Current research trends in early life stress and depression: review of human studies on sensitive periods, gene-environment interactions, and epigenetics. (United States)

    Heim, Christine; Binder, Elisabeth B


    Early life stress, such as childhood abuse, neglect and loss, is a well established major risk factor for developing depressive disorders later in life. We here summarize and discuss current developments in human research regarding the link between early life stress and depression. Specifically, we review the evidence for the existence of sensitive periods for the adverse effects of early life stress in humans. We further review the current state of knowledge regarding gene×environment (G×E) interactions in the effects of early life stress. While multiple genes operate in multiple environments to induce risk for depression after early life stress, these same genes also seem to enhance the beneficial effects of a positive early environment. Also, we discuss the epigenetic mechanisms that might underlie these G×E interactions. Finally, we discuss the potential importance of identifying sensitive time periods of opportunity, as well as G×E interactions and epigenetic mechanisms, for early interventions that might prevent or reverse the detrimental outcomes of early life stress and its transmission across generations. Copyright © 2011 Elsevier Inc. All rights reserved.

  19. Exploration Life Support Critical Questions for Future Human Space Missions (United States)

    Ewert, Michael K.; Barta, Daniel J.; McQuillan, Jeff


    Exploration Life Support (ELS) is a project under NASA s Exploration Technology Development Program. The ELS Project plans, coordinates and implements the development of advanced life support technologies for human exploration missions in space. Recent work has focused on closed loop atmosphere and water systems for a lunar outpost, including habitats and pressurized rovers. But, what are the critical questions facing life support system developers for these and other future human missions? This paper explores those questions and discusses how progress in the development of ELS technologies can help answer them. The ELS Project includes Atmosphere Revitalization Systems (ARS), Water Recovery Systems (WRS), Waste Management Systems (WMS), Habitation Engineering, Systems Integration, Modeling and Analysis (SIMA), and Validation and Testing, which includes the sub-elements Flight Experiments and Integrated Testing. Systems engineering analysis by ELS seeks to optimize the overall mission architecture by considering all the internal and external interfaces of the life support system and the potential for reduction or reuse of commodities. In particular, various sources and sinks of water and oxygen are considered along with the implications on loop closure and the resulting launch mass requirements.

  20. From the Beginning: The "Journal of Chemical Education" and Secondary School Chemistry (United States)

    Lagowski, Joseph J.


    The people, events, and issues that were involved in the beginning and the evolution of the "Journal of Chemical Education" and the Division of Chemical Education (DivCHED) are traced and discussed. The constitution of the American Chemical Society incorporates the roots of chemical education as an area of interest to the Society. Both…

  1. An attempt to estimate the economic value of the loss of human life due to landslide and flood events in Italy (United States)

    Salvati, Paola; Bianchi, Cinzia; Hussin, Haydar; Guzzetti, Fausto


    Landslide and flood events in Italy cause wide and severe damage to buildings and infrastructure, and are frequently involved in the loss of human life. The cost estimates of past natural disasters generally refer to the amount of public money used for the restoration of the direct damage, and most commonly do not account for all disaster impacts. Other cost components, including indirect losses, are difficult to quantify and, among these, the cost of human lives. The value of specific human life can be identified with the value of a statistical life (VLS), defined as the value that an individual places on a marginal change in their likelihood of death This is different from the value of an actual life. Based on information of fatal car accidents in Italy, we evaluate the cost that society suffers for the loss of life due to landslide and flood events. Using a catalogue of fatal landslide and flood events, for which information about gender and age of the fatalities is known, we determine the cost that society suffers for the loss of their life. For the purpose, we calculate the economic value in terms of the total income that the working-age population involved in the fatal events would have earned over the course of their life. For the computation, we use the pro-capita income calculated as the ratio between the GDP and the population value in Italy for each year, since 1980. Problems occur for children and retired people that we decided not to include in our estimates.

  2. Impact of economic development on quality of life and human happiness: a study on urban socio economic classes of suburban Mumbai

    Directory of Open Access Journals (Sweden)

    Debjani Banerjee


    Full Text Available This paper emphasizes that for a nation to revitalize in terms of development, not only does it need to evaluate in terms of GDP growth rate, but also has to consider the Quality of Life of its citizen and their human happiness. There is strong correlation between macro-economic development parameters like health, education, GDP growth rate and Quality of Life Index, expressed through HDI. It also has correlation with subjective quality of life based on the perception of urban socio economic classes, as measured in this study. The subjective quality of life is studied through five parameters like Quality of house, education, health care, transportation and recreation facilities. Human happiness is evaluated through the perception of respondents towards change in their financial conditions and consumption expenditure influencing their quality of life. This empirical research through spearman’s rank correlation tried to establish the relationship between macro-economic indicators with the quality of life parameters as perceived by people. The study was conducted in Mumbai, and its suburban areas .with a sample of 850 respondents taken through structured questionnaire, during 2012-13. It was observed from A. T. Kearney’s GRDI report that India was ranking between first five positions, consistently in terms of Modern Trade Retail Business since 2000. The managerial implication of the study highlights the association of quantitative economic development with larger aspect of human development, for the policy makers to understand the various areas which needs to be taken care to cater towards revitalizing the development of the nation


    Directory of Open Access Journals (Sweden)

    L. V. Martseniuk


    Full Text Available Purpose of the work is to substantiate the development of railway tourism in the context of human needs in accordance with the theory of individual life space. Methodology. Theoretical and methodological basis of the study is the provisions of the economic theory, management theory, corporate governance. The rational activity of travel agencies is based on the principles of economic equilibrium; Ukrainian population demand for railway tourism was determined with the help of market research and anonymous survey; to explore the real balance between the demand for tourist rail transport and the potential of the required volume of services the paper suggests the balance method. Since any travel company is an open system and is completely dependent on environmental factors, we proposed a method for estimating the factors of internal and external environment. Originality. The element of originality is compilation of existing concepts to the definition of the individual as a subject of life property, for the understanding of human relationships and its external environment. The paper developed the issue of the ability to influence the value of human life space with the help of tourist services. Conclusions. Market research conducted by the author has shown that in Ukraine there is a certain demand for tourist transport by rail, because it is more reliable, safer and more comfortable than the road transport. It is proved that the development of a new innovative project is very timely, as it will allow: to develop tourist infrastructure of Ukraine and bring it to the domestic and foreign tourists; replenish the state and local budgets by tourists; create new jobs for the population and improve their living level; partially reduce the loss-making passenger sector by increasing the volume of rail transport; expand life space for the people of Ukraine that will allow raising the intellectual level of the individual.

  4. Evaluation of TV Series "Beginning Sewing" Albany Area, New York Cooperative Extension. Special Report No. 24. (United States)

    Cheney, Martha A.; And Others

    A knowledge test covering subject matter of the Beginning Sewing TV series was sent to 344 registrants following the series, to measure the program effectiveness. Although the response was small (38%), characteristics of the viewers were identified: median age of 44.1 years; married for 21.3 years, family size of 3.8, completion of an average of…

  5. Tracing a Beginning Elementary Teacher’s Development of Identity for Science Teaching

    NARCIS (Netherlands)

    Avraamidou, Lucy


    The purpose of this case study was to examine a beginning elementary teacher’s development of identity for science teaching from her first year at university, her field experience, and through her first year of teaching. Several kinds of data were collected over a period of 5 years through different

  6. Aggregating Concept Map Data to Investigate the Knowledge of Beginning CS Students (United States)

    Mühling, Andreas


    Concept maps have a long history in educational settings as a tool for teaching, learning, and assessing. As an assessment tool, they are predominantly used to extract the structural configuration of learners' knowledge. This article presents an investigation of the knowledge structures of a large group of beginning CS students. The investigation…

  7. Developing Interactional Competence through Video-Based Computer-Mediated Conversations: Beginning Learners of Spanish (United States)

    Tecedor Cabrero, Marta


    This dissertation examines the discourse produced by beginning learners of Spanish using social media. Specifically, it looks at the use and development of interactional resources during two video-mediated conversations. Through a combination of Conversation Analysis tools and quantitative data analysis, the use of turn-taking strategies, repair…

  8. First year effects of induction arrangements on beginning teachers' psychological processes

    NARCIS (Netherlands)

    Helms-Lorenz, Michelle; Slof, Bert; van de Grift, Wim


    This study examined the (1) effects of a supportive program (i.e., induction arrangement) on beginning teachers' (BTs') psychological processes after a period of 1 year and (2) psychological paths of influence of the arrangement. Participants (56 Dutch secondary schools with 143 BTs) were randomly

  9. Determination of Partition coefficients for a Mixture of Volatile Organic Compounds in Rats and Humans at Different Life Stages

    National Research Council Canada - National Science Library

    Mahle, Deidre A; Gearhart, Jeffrey M; Godfrey, Richard J; Mattie, David R; Cook, Robert S; Grisby, Claude C


    .... Partition coefficients (PCs) are an integral component of pharmacokinetic models and determining differences in tissue partitioning of volatile organic chemicals across life stages can help reduce the uncertainty in risk assessment...

  10. Toward an Understanding of the Beginning-Teacher Experience: Curricular Insights for Teacher Education. (United States)

    Stark, Sheila


    Discusses one teacher's phenomenological journey toward understanding of the beginning teacher experience, focusing on possibilities for being and the importance of pedagogic caring demonstrated by two novice teachers, Jane and Kim. Views pedagogy as a way of observing, listening, and relating to children, not as a learnable technique or action.…

  11. Does Teaching Experience Matter? The Beliefs and Practices of Beginning and Experienced Physics Teachers (United States)

    Caleon, Imelda S.; Tan, Yuen Sze Michelle; Cho, Young Hoan


    This study utilized multiple data sources to examine the beliefs about learning and teaching physics and the instructional practices of five beginning teachers and seven experienced teachers from Singapore. Our study was implemented in the unique context of teachers teaching the topic of electricity to students grouped according to academic…

  12. An Investigation of Anglicized Spanish as a Communication Strategy in the Beginning Spanish Classroom (United States)

    Kobeck, Ashley Brianne


    Considering the recent increase in Spanish use in the United States, particularly as reflected in the media, beginning Spanish students are entering their classrooms with knowledge of phrases such as "hasta la vista" and "numero uno," regardless of their amount of previous formal Spanish study. The present research focuses on…

  13. Humanized HLA-DR4.RagKO.IL2RγcKO.NOD (DRAG) mice sustain the complex vertebrate life cycle of Plasmodium falciparum malaria. (United States)

    Wijayalath, Wathsala; Majji, Sai; Villasante, Eileen F; Brumeanu, Teodor D; Richie, Thomas L; Casares, Sofia


    Malaria is a deadly infectious disease affecting millions of people in tropical and sub-tropical countries. Among the five species of Plasmodium parasites that infect humans, Plasmodium falciparum accounts for the highest morbidity and mortality associated with malaria. Since humans are the only natural hosts for P. falciparum, the lack of convenient animal models has hindered the understanding of disease pathogenesis and prompted the need of testing anti-malarial drugs and vaccines directly in human trials. Humanized mice hosting human cells represent new pre-clinical models for infectious diseases that affect only humans. In this study, the ability of human-immune-system humanized HLA-DR4.RagKO.IL2RγcKO.NOD (DRAG) mice to sustain infection with P. falciparum was explored. Four week-old DRAG mice were infused with HLA-matched human haematopoietic stem cells (HSC) and examined for reconstitution of human liver cells and erythrocytes. Upon challenge with infectious P. falciparum sporozoites (NF54 strain) humanized DRAG mice were examined for liver stage infection, blood stage infection, and transmission to Anopheles stephensi mosquitoes. Humanized DRAG mice reconstituted human hepatocytes, Kupffer cells, liver endothelial cells, and erythrocytes. Upon intravenous challenge with P. falciparum sporozoites, DRAG mice sustained liver to blood stage infection (average 3-5 parasites/microlitre blood) and allowed transmission to An. stephensi mosquitoes. Infected DRAG mice elicited antibody and cellular responses to the blood stage parasites and self-cured the infection by day 45 post-challenge. DRAG mice represent the first human-immune-system humanized mouse model that sustains the complex vertebrate life cycle of P. falciparum without the need of exogenous injection of human hepatocytes/erythrocytes or P. falciparum parasite adaptation. The ability of DRAG mice to elicit specific human immune responses to P. falciparum parasites may help deciphering immune correlates

  14. Does the Social Working Environment Predict Beginning Teachers' Self-Efficacy and Feelings of Depression? (United States)

    Devos, Christelle; Dupriez, Vincent; Paquay, Leopold


    We investigate how the social working environment predicts beginning teachers' self-efficacy and feelings of depression. Two quantitative studies are presented. The results show that the goal structure of the school culture (mastery or performance orientation) predicts both outcomes. Frequent collaborative interactions with colleagues are related…

  15. The Beginnings of X-ray Crystallography: A Profile on the Two Braggs

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 19; Issue 12. The Beginnings of X-ray Crystallography: A Profile on the Two Braggs. T N Guru Row. Article-in-a-Box Volume 19 Issue 12 December 2014 pp 1071-1073. Fulltext. Click here to view fulltext PDF. Permanent link:

  16. Factors Influencing Beginning Teacher Retention in the Diocese of St. Augustine Catholic Schools (United States)

    Bronsard, Patricia


    Researchers explored the problem of teacher retention, especially among beginning teachers, and noted a lack of consensus on why teachers leave teaching and how to retain the teachers. Private school studies include Catholic school data, but few researchers isolated the data or used data-gathering instruments to examine Catholic school issues,…

  17. The sustainability of a teacher professional development programme for beginning urban teachers

    NARCIS (Netherlands)

    Gaikhorst, L.; Beishuizen, J.J.J.; Zijlstra, B.J.H.; Volman, M.L.L.


    This study investigated the long-term effects of a professional development intervention for beginning urban teachers and explored which characteristics and activities in school organisations contributed to the sustainability of these effects. A quasi-experimental study (n = 72) investigated whether

  18. The Human Microbiota in Early Life

    DEFF Research Database (Denmark)

    Mortensen, Martin Steen

    knowledge concerning microbiota composition, development and function in other areas of human body. Lack of knowledge about the microbiota development in the airways is an example of such a deficiency. The work presented in this PhD thesis is based on the vast sample collection of the COPSAC2010 cohort......, with 700 mother-infant pairs. The objectives were to perform a detailed examination of the mothers’ vaginal microbiota, describe the early composition and development of the microbiota in the airways of their infants, and determine whether the infants’ microbiota are affected by that of their mothers...... or not. Manuscript I examines the composition and stability of vaginal microbiota, as well as how the mothers’ microbiota contribute to the early bacterial colonization of their infants. In this study, we first confirmed that the vaginal microbiota of the women in the COPSAC2010 cohort represent...

  19. Human life: genetic or social construction? (United States)

    Yudin, Boris


    I am going to discuss some present-day tendencies in the development of the very old debate on nature vs nurture. There is a widespread position describing the history of this debate as a pendulum-like process. Some three decades ago there was a time of overwhelming prevalence of the position stressing social factors in determining human character and behavior; now the pendulum has come to the opposite side and those who stress the role of biology, of genes are in favor. Yet in my view rather acute opposition of both positions still exists. Its existence depends not so much on new scientific discoveries as on some social and cultural factors which are more conservative than the development of science. More than that, we can even talk about competition of these two positions.

  20. Marriage in North-Western Transylvania (2nd Half of the 19th Century – Beginning of the 20th Century). External Conditionings and Marital Strategies


    Brie, Mircea


    Marriage in North-Western Transylvania (2nd Half of the 19th Century – Beginning of the 20th Century). External Conditionings and Marital Strategies In the latter half of the 19th century and the beginning of the 20th century, in north-western Transylvania there was a traditional rural society, except for some urban centres and their neighbouring areas (the urban character is also proved by the analysis of the marital behaviour). The major events in the family life, such as baptism, marriage ...

  1. A Diagrammatic Exposition of Regression and Instrumental Variables for the Beginning Student (United States)

    Foster, Gigi


    Some beginning students of statistics and econometrics have difficulty with traditional algebraic approaches to explaining regression and related techniques. For these students, a simple and intuitive diagrammatic introduction as advocated by Kennedy (2008) may prove a useful framework to support further study. The author presents a series of…

  2. An Artistic Criticism of Writing to Read, A Computer-Based Program for Beginning Readers. (United States)

    Huenecke, Dorothy


    Uses aesthetic criteria and artistic criticism to explore possible meanings in Writing to Read, a computer-based program for beginning readers. Findings based on over 25 hours of observation showed that the program's enactment frequently compromised balance. Control drowned out individuality, conformity diminished exploration opportunities, and…

  3. Reformation and transformation of charity work at the beginning of the new time

    Directory of Open Access Journals (Sweden)

    Ardashkin Igor B.


    Full Text Available This article is aimed at studying the transformation of Christian charity at the beginning of the New Time and the analysis of changes ongoing in this sphere. The authors of this research start with the analysis of the situation that had been formed in the economy, culture and activity of the Roman Catholic Church in the late Middle Ages. Such a preliminary excursion into the historical domain is not coincidental. It assists understanding the reasons for the Reformation and later events. However, “in the beginning was the Word”, therefore, the text analyzes the ideas of such founding fathers of Protestantism as Martin Luther, John Calvin, Huldrych Zwingli. The new ideology along with the sociocultural and socioeconomic factors promoted the formation of a radically different and more creative social system, also including the charity sphere that became more rational, practical and rough.

  4. [Stress, Needs, and Quality of Life of People Living With Human Immunodeficiency Virus/AIDS in North East China]. (United States)

    Tsai, Meng-Chu; Lu, Po-Liang; Wu, Shiau-Jiun; Feng, Ming-Chu


    HIV/AIDS has become a chronic disease since anti-retroviral therapy has reduced the related rates of morbidity and mortality and maintained the immunity of people living with the human immunodeficiency virus / AIDS (PLWHA). PLWHA have psychological needs and many hope to improve their quality of life (QoL) over the long course of their treatment. Despite the large number of AIDS cases, there are limited reports addressing the issue of QoL among PLWHA in China. The present study aims to explore the stress, needs, QoL, and related factors among PLWHA in China. This cross-sectional, descriptive study used a structural questionnaire to assess the stress, needs, and QoL of 100 PLWHA in Shenyang, China. The most stressful issues faced by the participants were admitting HIV/AIDS status publicly and explaining their illness to others. Their needs were mainly related to receiving adequate information about HIV-related medical services, examination, and treatment and learning how to prevent disease progression. Among the four domains of QoL, the score in the physical domain was the lowest. The stress, needs, and QoL of the participants were significantly inter-correlated. However, only stress was found to predict QoL (β = -.25 to -.60, p stress, meet the needs, and improve the QoL of PLWHA, healthcare providers should work to lower the risk of divulgence, provide adequate healthcare information, and work to reduce the stigma and discrimination that is associated with having HIV/AIDS.

  5. Energy and quality of life

    International Nuclear Information System (INIS)

    Pasten, Cesar; Santamarina, Juan Carlos


    Energy is required to sustain life. A human-centered analysis of the worldwide energy situation is conducted in terms of quality of life-related variables that are affected, but not directly determined, by energy consumption. Data since 1980 show a continuous global increase in both energy consumption and quality of life, and lower population growth in countries with higher quality of life. Based on these trends, we advance non-linear energy consumption predictions and identify various plausible scenarios to optimally steer future energy demands, in order to maximize quality of life. The scenarios consider the coupling between energy consumption rate per capita, quality of life, population growth, social inequality, and governments’ energy-for-life efficiency. The results show the energy cost of increasing quality of life in the developing world, energy savings that can be realized by limiting overconsumption without impacting quality of life, and the role of governments on increasing energy-for-life efficiency and reducing social inequality. - Highlights: ► Energy consumption is inherently coupled to quality of life and population growth. ► Limiting overconsumption can keep 2040 energy consumption at 2010 levels. ► Restricting population growth has a minor effect on future energy demand. ► Social inequality reduction increases quality of life with a minor energy use. ► Increasing energy-for-life efficiency can keep 2040 energy use at 2010 levels.

  6. Creating a vision of teaching: Two cases of beginning teachers' beliefs and practices (United States)

    Guilbert, R. Ann

    The purpose of this study was three-fold: (1) to examine the teaching philosophies of two new teachers involved in the Salish I Research Project; (2) to uncover any relationship between the beginning teacher's instruction and personal practical philosophy of instruction; and, (3) to seek to understand the relationship between a written research-based rationale and instructional practice. This qualitative study consisted of two case studies of beginning teachers. Through the use of classroom observation, written anecdotal records, written reflections during student teaching, written research-based rationales, unstructured interview, and audiotaped formal exit interviews, a thick, rich description of the participants was compiled. Using the constant comparative method, an inductive analysis of the data was conducted by coding, unitizing, and categorizing the data to determine the beliefs of the participants. Both the exposed beliefs and those acted on during the first year of teaching are described. Results indicate that beginning teachers enter the classroom with images of their role in the classroom and that preservice programs have an influence on that image. Those images, however, are not always clear and clarity was an influential factor in the participants' ability to implement the knowledge and skills they had examined in their preservice program. Two images were particularly potent to the implementation of new teaching strategies. One of those images was the role and the influence of the teacher in the classroom. The second was the type of student outcomes that should result. These two images were "sharpened" when the participants were forced to assign language to describe the relationship between theory and practice. The results further indicate that beginning teachers who come from the same preservice programs enter their first year with a variety of images of teaching. The degree to which the image is implemented in the classroom appeared to be related to

  7. Old Believers in Tuva at the beginning of the 20th century and under People’s Republic of Tuva

    Directory of Open Access Journals (Sweden)

    Margarita P. Tatarinseva


    Full Text Available The article aims to analyze the specifics of culture and everyday life of the Old Believers’ (staroobryadtsy community in Tuva at the beginning of the 20th century, as well as under the People’s Republic of Tuva (1921-1944. Our study was based on research in the general history and culture of Old Belief in Russian and Siberia, as well as on the documents from the research archive of Tuva Institute for Humanities and Applied Socioeconomic Studies.   Old Believers who settled in Tuva (Uryankhaisky Krai in late 19th – early 20th century accounted for about a third of all Russian settlers. For the first two decades, their situation in the region was relatively favorable. For them, Tuva was a faraway region that suited well their isolationist lifestyle. It was the Promised Land, the Belovodye which ‘Antichrist’s henchmen’ (Russian government officials could not reach. In the natural abundance of Tuva they saw a country where every hard-working Christian could become master of his own household. Although settling in the new land with its often adverse conditions for farming could prove difficult, Old Believers managed to adapt to the new climate and build good relations with the local powers which rarely intervened into their lives. Alongside with farming and cattle breeding, Old Believers were involved in hunting, fishing, crafts and trade. Their situation, however, worsened when the People’s Republic of Tuva (PRT in the 1930s accelerated the Socialist reforms and implemented an anti-religious policy. Those Old Believers who refused to change their lifestyle due to religious considerations (i.e., evaded military conscription, etc., as well as clergy and monks, were given prison sentences that they had to serve outside Tuva. Old Believers protested against censuses, introduction of mandatory passports, universal education (at schools where atheism was an official policy, etc. Many families tried to find ’salvation’ by fleeing deep

  8. Man-Made Closed Ecological Systems as Model of Natural Ecosystems and as Means to Provide High Quality of Human Life in Adverse Environment (United States)

    Gitelson, I. I.; Harper, Lynn (Technical Monitor)


    For its more than thirty year long history, the experimental creation of closed ecological systems has from its very sources been distinctly and strongly motivated by the development of human life-support systems for space. As the trend developed its fundamental significance and broad opportunities of terrestrial applications of the technologies under development were coming to the foreground. Nowadays, it can be argued that development of closed ecosystems is experimental foundation of a new branch of ecology biospherics, the goal of which is to comprehend the regularities of existence of the biosphere as a unique in the Universe (in that part of it that we know, at least) closed ecosystem. Closed technologies can be implemented in life-support systems under adverse conditions of life on the Earth - in Arctic and Antarctic latitudes, deserts, high mountains or deep in the ocean, as well as under the conditions of polluted water and air. In space where the environment is hostile for life all around the cell of life should be sealed and the life-support system as close to the ideally closed cyclic turnover of the matter as possible. Under terrestrial conditions designers should strive for maximum closure of the limiting factor: water - in deserts, oxygen - in high mountains, energy - in polar latitudes, etc. Essential closure of a life-support systems withstands also pollution of the environment by the wastes of human vital activity. This is of particular importance for the quarantine of visited planets, and on the Earth under the conditions of deficient heat in high latitudes and water in and areas. The report describes experimental ecosystem 'BIOS' and exohabitats being designed on its basis, which are adapted to various conditions, described capacities of the Center for Closed Ecosystems in Drasnoyarsk for international collaboration in research and education in this field.

  9. Areas of Inquiry : Guiding FSSD practitioners at the beginning of a change initiative towards sustainability


    Hogenboom, Michaela; Mireault, Amy; Stolz, Thaela


    This research aims to support sustainability practitioners at the beginning of a change initiative towards sustainability to increase the success of the change. Moving towards sustainability is a complex journey and requires radical and structural transformational change in companies. Mutual understanding of the company and the practitioner is required to design a suitable change process. Existing tools related to sustainability, change management, corporate analysis and assessment were analy...

  10. Mentioning race at the beginning of clinical case presentations: a survey of US medical schools. (United States)

    Nawaz, Hamayun; Brett, Allan S


    Medical students and doctors in the USA frequently mention the patient's race at the beginning of oral or written clinical case presentations. However, this practice is controversial. We aimed to determine whether US medical schools explicitly teach students to mention race at the beginning of case presentations, and to collect additional information on the schools' perspectives on this practice. An Internet-based questionnaire was submitted to directors of courses on history taking and physical examination at all US medical schools. The response rate was 85%. Students are taught to mention race routinely at 11% of schools and selectively at 63% of schools; this practice is discouraged at 9% of schools and not addressed at 18% of schools. Most respondents noted that resident doctors at their institutions routinely mention race at the beginning of case presentations. Even at schools in which mentioning race is discouraged or not addressed, students tend to include race during their clinical rotations. Respondents were divided on whether a standardised approach to inclusion of race should exist at US schools. Teaching about inclusion or exclusion of race in the opening statement of clinical case presentations varies across US medical schools. This variation presents an opportunity for medical educators to discuss tensions between stereotyping and cultural competence in medical education.

  11. Life's crucible. (United States)

    Radetsky, P


    Research by German chemists Gunter Wachtershauser and Claudia Huber about the origins of life is reviewed. Other theories about the beginning of life on Earth are examined with comments by noted researchers.

  12. Allostasis and the Human Brain: Integrating Models of Stress from the Social and Life Sciences (United States)

    Ganzel, Barbara L.; Morris, Pamela A.; Wethington, Elaine


    We draw on the theory of allostasis to develop an integrative model of the current stress process that highlights the brain as a dynamically adapting interface between the changing environment and the biological self. We review evidence that the core emotional regions of the brain constitute the primary mediator of the well-established association…

  13. Visible humans, vanishing bodies, and virtual nursing: complications of life, presence, place, and identity. (United States)

    Sandelowski, Margarete


    The emergence of the posthuman body and the disappearance of the humanist body serve as background for the rediscovery of the body as resource and problem in nursing. At the precise moment when the fleshy body is deemed increasingly irrelevant and immaterial in cyberspace come divergent moves in nursing toward not only resurrecting this body, but also toward virtual environments of nursing care, where fleshy bodies never encounter each other. The posthuman conflation of bodies and information poses the greatest challenge yet to the secure place, presence, and identity of nursing in health care.

  14. [The dignity of the frozen human embryo]. (United States)

    Zurriaráin, R Germán


    The issue of the dignity of the human embryo is one of the key questions in bioethics debate today. The human being's dignity lies in the original and unique individuality that every embryo has. If there is no respect and defense of the human body from the very first moment of its appearance, it is impossible to assert the dignity of any human being. For this reason, it does not seem good for human dignity that human beings, in their incipient phase, should suffer from the halting of their biological functions. The practice of cryopreservation of human embryos shows a loss of the sense of the value of each individual human being. This paper is developed from a descriptive and interdisciplinary study of key ethical concepts in this subject. 1. Respect for the embryo's dignity must indeed exist from the beginning of its life. 2. For this reason, this respect does not depend on any operation, but on the eminence of its being. 3. Not only is freezing a habitat which contradicts the dignity of life, but it is also the expression of a will that determines and decides the human life of weaker beings. The embryo's dignity is thus reduced to the value of use where it is not out of date.

  15. Fertility of populations as a function of the attained level of life expectancy in the course of human evolution. (United States)

    Langner, G


    "¿Aging societies' with increasing life expectancies of the average of all their members are facts in modern history that are disputed by nobody. What is disputed by the most renowned names in demography, however, is that aging populations are a consequence of the fall in mortality and thus the increase in life expectancy. It is claimed that the [principal] reason for ¿aging' is to be found in a drop in fertility. In this sense today's demographers regard as a standard result: ¿Variations in fertility are of more significance for the age structure of populations than variations in mortality'. In the following paper this thesis, which is based on a neo-Malthusian interpretation of the role of fertility in the demographic process, will be questioned." excerpt

  16. Radiocarbon dating of the human eye lens crystallines reveal proteins without carbon turnover throughout life

    DEFF Research Database (Denmark)

    Lynnerup, Niels; Kjeldsen, Henrik; Heegaard, Steffen


    dating is made possible by comparing the (14)C content of the lens crystallines to the so-called bomb pulse, i.e. a plot of the atmospheric (14)C content since the Second World War, when there was a significant increase due to nuclear-bomb testing. Since the change in concentration is significant even...

  17. Life 3.0: being human in the age of artificial intelligence

    National Research Council Canada - National Science Library

    Tegmark, Max


    ...? How likely is the emergence of suprahuman intelligence? A.I. is the future of science, technology, and business--and there is no person better qualified or situated to explore that future than Max Tegmark. What has A.I. brought us...

  18. The Effects of Toxic Particles in Human Lung Cells - Research Area 8. Life Sciences (United States)


    silver and gold nanoparticle-induced effects; and 6) Assess metal levels in whale skin biopsies in the Gulf of Mexico. The first five aims focused... metal particle genotoxicity; 4) Characterize metal particle-induced chromosome instability; 5) Compare silver and gold nanoparticle-induced effects; and...nanoparticles, particles associated with metal -on- metal hip implants and microparticles of military concern. We found that silver , gold and titanium dioxide

  19. Life Sciences Division and Center for Human Genome Studies 1994

    Energy Technology Data Exchange (ETDEWEB)

    Cram, L.S.; Stafford, C. [comp.


    This report summarizes the research and development activities of the Los Alamos National Laboratory`s Life Sciences Division and the biological aspects of the Center for Human Genome Studies for the calendar year 1994. The technical portion of the report is divided into two parts, (1) selected research highlights and (2) research projects and accomplishments. The research highlights provide a more detailed description of a select set of projects. A technical description of all projects is presented in sufficient detail so that the informed reader will be able to assess the scope and significance of each project. Summaries useful to the casual reader desiring general information have been prepared by the group leaders and appear in each group overview. Investigators on the staff of the Life Sciences Division will be pleased to provide further information.

  20. Treatment of severe life threatening hypocalcemia with recombinant human teriparatide in patients with postoperative hypoparathyroidism - a case series. (United States)

    Andrysiak-Mamos, Elżbieta; Żochowska, Ewa; Kaźmierczyk-Puchalska, Agnieszka; Popow, Michał; Kaczmarska-Turek, Dorota; Pachucki, Janusz; Bednarczuk, Tomasz; Syrenicz, Anhelli


    Hypocalcaemia is a common postoperative complication, both after the resection of parathyroid adenoma associated with primary hyperparathyroidism and after total thyroidectomy due to thyroid cancer or nodular goitre. For a few years, in patients with postoperative hypoparathyroidism and severe hypocalcaemia, who cannot discontinue intravenous calcium preparations even with the use of high vitamin D doses, attempts have been made to add recombinant human parathormone (rhPTH) to the treatment schedule. In this work, for the first time in Poland, we demonstrate the potential use of teriparatide for the treatment of severe hypocalcaemia based on three different cases of postoperative hypoparathyroidism. Case 1. Female (52) with postoperative hypoparathyroidism, after total thyroidectomy and the removal of lower left parathyroid gland due to hyperparathyroidism, several weeks after the surgery still required intravenous calcium infusions because of tetany symptoms. Just one month of teriparatide treatment at 20 μg/0.08 mL given in daily subcutaneous injections proved sufficient to control calcium levels with oral calcium and vitamin D preparations during the next few days until total resolution of hypocalcaemia symptoms and the achievement and maintenance of laboratory normocalcaemia in the following weeks. Female (33) with hypoparathyroidism following total thyroidectomy in 1996 because of papillary thyroid cancer, with congenital tubulopathy associated with renal loss of calcium and magnesium, and the symptoms of tetany recurring since the day of surgery, requiring intravenous calcium administration every 2-3 days. Currently, the patient has been hospitalised because of venous port infection, the only venous access, which made intravenous therapy impossible. Because of the life-threatening condition of the patient, bridging teriparatide treatment was prepared (20 μg/0.08 mL). Complete resolution of clinical symptoms of hypocalcaemia was obtained with teriparatide