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Sample records for beauty structure functions

  1. The ratio of the beauty structure functions R{sup b}=(F{sub L}{sup b})/(F{sub 2}{sup b}) at low x

    Energy Technology Data Exchange (ETDEWEB)

    Boroun, G.R., E-mail: grboroun@gmail.com

    2014-07-15

    We study the structure functions F{sub k}{sup b}(x,Q{sup 2}) (k=2,L) and the reduced cross section σ{sub r}{sup b}(x,Q{sup 2}) for small values of Bjorken's x variable with respect to the hard (Lipatov) pomeron for the gluon distribution and provide a compact formula for the ratio R{sup b} that is useful to extract the beauty structure function from the beauty reduced cross section, in particular at DESY HERA. Also we show that the effects of the nonlinear corrections to the gluon distribution tame the behavior of the beauty structure function and the beauty reduced cross section at low x.

  2. Is better beautiful or is beautiful better? Exploring the relationship between beauty and category structure.

    Science.gov (United States)

    Sanders, Megan; Davis, Tyler; Love, Bradley C

    2013-06-01

    We evaluate two competing accounts of the relationship between beauty and category structure. According to the similarity-based view, beauty arises from category structure such that central items are favored due to their increased fluency. In contrast, the theory-based view holds that people's theories of beauty shape their perceptions of categories. In the present study, subjects learned to categorize abstract paintings into meaningfully labeled categories and rated the paintings' beauty, value, and typicality. Inconsistent with the similarity-based view, beauty ratings were highly correlated across conditions despite differences in fluency and assigned category structure. Consistent with the theory-based view, beautiful paintings were treated as central members for categories expected to contain beautiful paintings (e.g., art museum pieces), but not in others (e.g., student show pieces). These results suggest that the beauty of complex, real-world stimuli is not determined by fluency within category structure but, instead, interacts with people's prior knowledge to structure categories.

  3. Measurement of the charm and beauty structure functions using the H1 vertex detector at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Aaron, F.D.; Alexa, C.; Preda, T.; Rotaru, M.; Stoicea, G.; Zus, R. [National Institute for Physics and Nuclear Engineering (NIPNE), Bucharest (Romania); Aldaya Martin, M.; Alimujiang, K.; Antunovic, B.; Bartel, W.; Brandt, G.; Campbell, A.J.; Cholewa, A.; Deak, M.; Boer, Y. de; Eckerlin, G.; Elsen, E.; Felst, R.; Fischer, D.J.; Fleischer, M.; Gayler, J.; Glazov, A.; Gouzevitch, M.; Grell, B.R.; Haidt, D.; Helebrant, C.; Janssen, M.E.; Jung, H.; Katzy, J.; Kleinwort, C.; Knutsson, A.; Kraemer, M.; Krastev, K.; Kutak, K.; Levonian, S.; Lipka, K.; List, J.; Marti, L.; Meyer, A.B.; Meyer, H.; Meyer, J.; Michels, V.; Niebuhr, C.; Nikiforov, A.; Nozicka, M.; Olsson, J.E.; Panagoulias, I.; Papadopoulou, T.; Pitzl, D.; Placakyte, R.; Radescu, V.; Rurikova, Z.; Schmitt, S.; Schoeffel, L.; Sefkow, F.; Staykova, Z.; Steder, M.; Vargas Trevino, A.; Vinokurova, S.; Driesch, M. von den; Wissing, C.; Wuensch, E. [DESY, Hamburg (Germany); Andreev, V.; Belousov, A.; Eliseev, A.; Fomenko, A.; Gogitidze, N.; Lebedev, A.; Loktionova, N.; Malinovski, E.; Rusakov, S.; Shtarkov, L.N.; Soloviev, Y.; Vazdik, Y. [Lebedev Physical Institute, Moscow (Russian Federation); Asmone, A.; Stella, B. [Dipt. di Fisica Universita di Roma Tre (Italy); INFN Roma 3, Rome (Italy); Backovic, S.; Dubak, A.; Lastovicka-Medin, G.; Picuric, I.; Raicevic, N. [Univ. of Montenegro, Faculty of Science, Podgorica (ME); Baghdasaryan, A.; Ghazaryan, S.; Volchinski, V.; Zohrabyan, H. [Yerevan Physics Inst., Yerevan (Armenia); Barrelet, E. [CNRS/IN2P3, LPNHE, Universites Paris VI et VII, Paris (France); Begzsuren, K.; Ravdandorj, T.; Tseepeldorj, B. [Inst. of Physics and Technology of the Mongolian Academy of Sciences, Ulaanbaatar (Mongolia); Bizot, J.C.; Brisson, V.; Delcourt, B.; Jacquet, M.; Li, G.; Pascaud, C.; Tran, T.H.; Zhang, Z.; Zomer, F. [CNRS/IN2P3, LAL, Univ. Paris-Sud, Orsay (France); Boudry, V.; Moreau, F.; Specka, A. [CNRS/IN2P3, LLR, Ecole Polytechnique, Palaiseau (France)] [and others

    2010-01-15

    Inclusive charm and beauty cross sections are measured in e{sup -}p and e{sup +} p neutral current collisions at HERA in the kinematic region of photon virtuality 5{<=}Q {sup 2}{<=}2000 GeV{sup 2} and Bjorken scaling variable 0.0002{<=}x{<=}0.05. The data were collected with the H1 detector in the years 2006 and 2007 corresponding to an integrated luminosity of 189 pb{sup -1}. The numbers of charm and beauty events are determined using variables reconstructed by the H1 vertex detector including the impact parameter of tracks to the primary vertex and the position of the secondary vertex. The measurements are combined with previous data and compared to QCD predictions. (orig.)

  4. Measurement of the charm and beauty structure functions using the H1 vertex detector at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Aaron, F.D. [National Institute for Physics and Nuclear Engineering (NIPNE), Bucharest (Romania); Bucharest Univ. (Romania). Faculty of Physics; Aldaya Martin, M. [DESY, Hamburg (Germany); Alexa, C. [National Institute for Physics and Nuclear Engineering (NIPNE), Bucharest (RO)] (and others)

    2009-06-15

    Inclusive charm and beauty cross sections are measured in e{sup -}p and e{sup +}p neutral current collisions at HERA in the kinematic region of photon virtuality 5{<=}Q{sup 2}{<=}2000 GeV{sup 2} and Bjorken scaling variable 0.0002{<=}x{<=}0.05. The data were collected with the H1 detector in the years 2006 and 2007 corresponding to an integrated luminosity of 189 pb{sup -1}. The numbers of charm and beauty events are determined using variables reconstructed by the H1 vertex detector including the impact parameter of tracks to the primary vertex and the position of the secondary vertex. The measurements are combined with previous data and compared to QCD predictions. (orig.)

  5. Measurement of the Charm and Beauty Structure Functions using the H1 Vertex Detector at HERA

    CERN Document Server

    Aaron, FD; Alexa, C; Alimujiang, K; Andreev, V; Antunovic, B; Asmone, A; Backovic, S; Baghdasaryan, A; Barrelet, E; Bartel, W; Begzsuren, K; Belousov, A; Bizot, J C; Boudry, V; Bozovic-Jelisavcic, I; Bracinik, J; Brandt, G; Brinkmann, M; Brisson, V; Bruncko, D; Bunyatyan, A; Buschhorn, G; Bystritskaya, L; Campbell, A J; Cantun Avila, K B; Cassol-Brunner, F; Cerny, K; Cerny, V; Chekelian, V; Cholewa, A; Contreras, J G; Coughlan, J A; Cozzika, G; Cvach, J; Dainton, J B; Daum, K; Deak, M; de Boer, Y; Delcourt, B; Del Degan, M; Delvax, J; De Wolf, E A; Diaconu, C; Dodonov, V; Dossanov, A; Dubak, A; Eckerlin, G; Efremenko, V; Egli, S; Eliseev, A; Elsen, E; Falkiewicz, A; Favart, L; Fedotov, A; Felst, R; Feltesse, J; Ferencei, J; Fischer, D -J; Fleischer, M; Fomenko, A; Gabathuler, E; Gayler, J; Ghazaryan, Samvel; Glazov, A; Glushkov, I; Goerlich, L; Gogitidze, N; Gouzevitch, M; Grab, C; Greenshaw, T; Grell, B R; Grindhammer, G; Habib, S; Haidt, D; Helebrant, C; Henderson, R C W; Hennekemper, E; Henschel, H; Herbst, M; Herrera, G; Hildebrandt, M; Hiller, K H; Hoffmann, D; Horisberger, R; Hreus, T; Jacquet, M; Janssen, M E; Janssen, X; Jonsson, L; Jung, Andreas Werner; Jung, H; Kapichine, M; Katzy, J; Kenyon, I R; Kiesling, C; Klein, M; Kleinwort, C; Kluge, T; Knutsson, A; Kogler, R; Kostka, P; Kraemer, M; Krastev, K; Kretzschmar, J; Kropivnitskaya, A; Kruger, K; Kutak, K; Landon, M P J; Lange, W; Lastovicka-Medin, G; Laycock, P; Lebedev, A; Leibenguth, G; Lendermann, V; Levonian, S; Li, G; Lipka, K; Liptaj, A; List, B; List, J; Loktionova, N; Lopez-Fernandez, R; Lubimov, V; Lytkin, L; Makankine, A; Malinovski, E; Marage, P; Marti, Ll; Martyn, H -U; Maxfield, S J; Mehta, A; Meyer, A B; Meyer, H; Meyer, H; Meyer, J; Michels, V; Mikocki, S; Milcewicz-Mika, I; Moreau, F; Morozov, A; Morris, J V; Mozer, Matthias Ulrich; Mudrinic, M; Muller, K; Murin, P; Naumann, Th; Newman, P R; Niebuhr, C; Nikiforov, A; Nowak, G; Nowak, K; Nozicka, M; Olivier, B; Olsson, J E; Osman, S; Ozerov, D; Palichik, V; Panagoulias, I; Pandurovic, M; Papadopoulou, Th; Pascaud, C; Patel, G D; Pejchal, O; Perez, E; Petrukhin, A; Picuric, I; Piec, S; Pitzl, D; Placakyte, R; Pokorny, B; Polifka, R; Povh, B; Preda, T; Radescu, V; Rahmat, A J; Raicevic, N; Raspiareza, A; Ravdandorj, T; Reimer, P; Rizvi, E; Robmann, P; Roland, B; Roosen, R; Rostovtsev, A; Rotaru, M; Ruiz Tabasco, J E; Rurikova, Z; Rusakov, S; Salek, D; Sankey, D P C; Sauter, M; Sauvan, E; Schmitt, S; Schoeffel, L; Schoning, A; Schultz-Coulon, H -C; Sefkow, F; Shaw-West, R N; Shtarkov, L N; Shushkevich, S; Sloan, T; Smiljanic, Ivan; Soloviev, Y; Sopicki, P; South, D; Spaskov, V; Specka, Arnd E; Staykova, Z; Steder, M; Stella, B; Stoicea, G; Straumann, U; Sunar, D; Sykora, T; Tchoulakov, V; Thompson, G; Thompson, P D; Toll, T; Tomasz, F; Tran, T H; Traynor, D; Trinh, T N; Truol, P; Tsakov, I; Tseepeldorj, B; Turnau, J; Urban, K; Valkarova, A; Vallee, C; Van Mechelen, P; Vargas Trevino, A; Vazdik, Y; Vinokurova, S; Volchinski, V; von den Driesch, M; Wegener, D; Wissing, Ch; Wunsch, E; Zacek, J; Zalesak, J; Zhang, Z; Zhokin, A; Zimmermann, T; Zohrabyan, H; Zomer, F; Zus, R

    2010-01-01

    Inclusive charm and beauty cross sections are measured in e-p and e+p neutral current collisions at HERA in the kinematic region of photon virtuality 5beauty events are determined using variables reconstructed by the H1 vertex detector including the impact parameter of tracks to the primary vertex and the position of the secondary vertex. The measurements are combined with previous data and compared to QCD predictions.

  6. Construction of compactly supported orthonormal wavelets with beautiful structure

    Institute of Scientific and Technical Information of China (English)

    PENG Lizhong; WANG Yongge

    2004-01-01

    In this paper, a new method of constructing symmetric (antisymmetric) scaling and wavelet filters is introduced, and we get a new type of wavelet system that has very beautiful structure. Using this kind of wavelet system, we can achieve filters with the properties: rational, symmetric or antisymmetric, the lengths of the filters are shorter and the corresponding functions have higher smoothness, so they have good prospect in applications.

  7. Structural Determinants of Sleeping Beauty Transposase Activity.

    Science.gov (United States)

    Abrusán, György; Yant, Stephen R; Szilágyi, András; Marsh, Joseph A; Mátés, Lajos; Izsvák, Zsuzsanna; Barabás, Orsolya; Ivics, Zoltán

    2016-08-01

    Transposases are important tools in genome engineering, and there is considerable interest in engineering more efficient ones. Here, we seek to understand the factors determining their activity using the Sleeping Beauty transposase. Recent work suggests that protein coevolutionary information can be used to classify groups of physically connected, coevolving residues into elements called "sectors", which have proven useful for understanding the folding, allosteric interactions, and enzymatic activity of proteins. Using extensive mutagenesis data, protein modeling and analysis of folding energies, we show that (i) The Sleeping Beauty transposase contains two sectors, which span across conserved domains, and are enriched in DNA-binding residues, indicating that the DNA binding and endonuclease functions of the transposase coevolve; (ii) Sector residues are highly sensitive to mutations, and most mutations of these residues strongly reduce transposition rate; (iii) Mutations with a strong effect on free energy of folding in the DDE domain of the transposase significantly reduce transposition rate. (iv) Mutations that influence DNA and protein-protein interactions generally reduce transposition rate, although most hyperactive mutants are also located on the protein surface, including residues with protein-protein interactions. This suggests that hyperactivity results from the modification of protein interactions, rather than the stabilization of protein fold.

  8. The Functional and Three Beauty Theory: An Alternative Perspective on the Chinese Translation of English Advertisement

    Directory of Open Access Journals (Sweden)

    Lee Pin Ling

    2016-10-01

    Full Text Available Considering the multiracial, multicultural and multilingual background of the readers in Malaysia, it is very common to find advertisements with exactly the same graphics but in different languages. From the survey of previous studies, it is found that the Chinese translation of English advertisement in Malaysia has not received adequate attention from researchers. Apart from this, it is found that the adoption of the Three Beauty Theory into the translation of advertisement has not captured much attention from researchers. Thus, this study attempts to fill this gap by looking into the Chinese translation of English advertisement in Malaysian newspapers, based on the Functional Translation Theory and the Three Beauty Theory. The result of this study shows that the use of three aspects of Chinese language (meaning, sound and form in analysing and identifying the appellativeness of a Chinese translated English headline is appropriate. In addition to that, the effectiveness of Chinese translation of English advertisement headline, in terms of meaning, sound and form could be analysed and improved, based on the Three Beauty Theory. In short, the Functional Translation Theories provides a guideline on the purpose of translation, typology, and language function and translation strategy in the Chinese translation of English advertisement. On the other hand, the Three Beauty Theory safeguards the effectiveness and the beauty of Chinese language, in terms of meaning (idea, message, form (structure and sound (phonology. Keywords: Chinese translation, English advertisement, Functional Translation Theory, Three Beauty Theory

  9. Mitochondrial Cristae: Where Beauty Meets Functionality.

    Science.gov (United States)

    Cogliati, Sara; Enriquez, Jose A; Scorrano, Luca

    2016-03-01

    Mitochondrial cristae are dynamic bioenergetic compartments whose shape changes under different physiological conditions. Recent discoveries have unveiled the relation between cristae shape and oxidative phosphorylation (OXPHOS) function, suggesting that membrane morphology modulates the organization and function of the OXPHOS system, with a direct impact on cellular metabolism. As a corollary, cristae-shaping proteins have emerged as potential modulators of mitochondrial bioenergetics, a concept confirmed by genetic experiments in mouse models of respiratory chain deficiency. Here, we review our knowledge of mitochondrial ultrastructural organization and how it impacts mitochondrial metabolism.

  10. Jakobson’s zero and the pleasure and pitfalls of structural beauty

    DEFF Research Database (Denmark)

    Nielsen, Peter Juul

    2015-01-01

    In ‘Signe zéro’ (1939) Jakobson suggests a radical application of the zero notion in analysis of linguistic structure, arguing that ‘nothing’ is a relevant structural component not only on the expression plane, but also on the content plane, i.e.zero content as the signifié of a sign. The paper...... examines how this idea is rooted in the structuralist tradition of analysing difference and significant distinctions and how it is motivated by the pleasure of structural beauty. Focusing on one of Jakobson’s examples of zero signs, the analysis of gender in the Russian declension system, the paper...... criticises the simplification of empirical facts in Jakobson’s analysis and the reasoning behind accepting ‘nothing’ as a kind of content coding. This critical assessment draws on the description of sign distinctions in the structural-functional paradigm model of Nørgård-Sørensen et al. (2011) and Andersen...

  11. Evolutionary cell biology: functional insight from "endless forms most beautiful".

    Science.gov (United States)

    Richardson, Elisabeth; Zerr, Kelly; Tsaousis, Anastasios; Dorrell, Richard G; Dacks, Joel B

    2015-12-15

    In animal and fungal model organisms, the complexities of cell biology have been analyzed in exquisite detail and much is known about how these organisms function at the cellular level. However, the model organisms cell biologists generally use include only a tiny fraction of the true diversity of eukaryotic cellular forms. The divergent cellular processes observed in these more distant lineages are still largely unknown in the general scientific community. Despite the relative obscurity of these organisms, comparative studies of them across eukaryotic diversity have had profound implications for our understanding of fundamental cell biology in all species and have revealed the evolution and origins of previously observed cellular processes. In this Perspective, we will discuss the complexity of cell biology found across the eukaryotic tree, and three specific examples of where studies of divergent cell biology have altered our understanding of key functional aspects of mitochondria, plastids, and membrane trafficking.

  12. Electron crystallography--the waking beauty of structural biology.

    Science.gov (United States)

    Pope, Christopher R; Unger, Vinzenz M

    2012-08-01

    Since its debut in the mid 1970s, electron crystallography has been a valuable alternative in the structure determination of biological macromolecules. Its reliance on single-layered or double-layered two-dimensionally ordered arrays and the ability to obtain structural information from small and disordered crystals make this approach particularly useful for the study of membrane proteins in a lipid bilayer environment. Despite its unique advantages, technological hurdles have kept electron crystallography from reaching its full potential. Addressing the issues, recent initiatives developed high-throughput pipelines for crystallization and screening. Adding progress in automating data collection, image analysis and phase extension methods, electron crystallography is poised to raise its profile and may lead the way in exploring the structural biology of macromolecular complexes.

  13. Baby beautiful: adult attributions of infant competence as a function of infant attractiveness.

    Science.gov (United States)

    Stephan, C W; Langlois, J H

    1984-04-01

    To determine at what age children first elicit differential expectations from adults as a function of their appearance, a sample of black, Caucasian, and Mexican-American adults rated photographs of a sample of black, Caucasian, and Mexican-American infants at 3 time periods in the first year of life. These adults first rated the infants on physical attractiveness and then rated the infants on 12 bipolar adjectives. The adjectives were reduced to 4 dimensions of infant behavior by factor analysis. A strong beauty-is-good stereotype was associated with 3 of the dimensions. On the measures of smart - likable baby, good baby, and causes parents problems, there was a beauty-is-good bias that prevailed across ethnic groups. In contrast, no such bias was found on the measure of active baby. The activity index was expected to reflect positive characteristics, but it appears to have implied overactivity and irritability. Strong and consistent expectations for behavior of attractive and unattractive individuals thus appear to be elicited soon after birth in Caucasian and non-Caucasian populations.

  14. NMR solution structure of the RED subdomain of the Sleeping Beauty transposase.

    Science.gov (United States)

    Konnova, Tatiana A; Singer, Christopher M; Nesmelova, Irina V

    2017-03-27

    DNA transposons can be employed for stable gene transfer in vertebrates. The Sleeping Beauty (SB) DNA transposon has been recently adapted for human application and is being evaluated in clinical trials, however its molecular mechanism is not clear. SB transposition is catalyzed by the transposase enzyme, which is a multi-domain protein containing the catalytic and the DNA-binding domains. The DNA-binding domain of the SB transposase contains two structurally independent subdomains, PAI and RED. Recently, the structures of the catalytic domain and the PAI subdomain have been determined, however no structural information on the RED subdomain and its interactions with DNA has been available. Here, we used NMR spectroscopy to determine the solution structure of the RED subdomain and characterize its interactions with the transposon DNA.

  15. Sleeping Beauty transposase structure allows rational design of hyperactive variants for genetic engineering

    Science.gov (United States)

    Voigt, Franka; Wiedemann, Lisa; Zuliani, Cecilia; Querques, Irma; Sebe, Attila; Mátés, Lajos; Izsvák, Zsuzsanna; Ivics, Zoltán; Barabas, Orsolya

    2016-01-01

    Sleeping Beauty (SB) is a prominent Tc1/mariner superfamily DNA transposon that provides a popular genome engineering tool in a broad range of organisms. It is mobilized by a transposase enzyme that catalyses DNA cleavage and integration at short specific sequences at the transposon ends. To facilitate SB's applications, here we determine the crystal structure of the transposase catalytic domain and use it to model the SB transposase/transposon end/target DNA complex. Together with biochemical and cell-based transposition assays, our structure reveals mechanistic insights into SB transposition and rationalizes previous hyperactive transposase mutations. Moreover, our data enables us to design two additional hyperactive transposase variants. Our work provides a useful resource and proof-of-concept for structure-based engineering of tailored SB transposases. PMID:27025571

  16. Sleeping Beauty transposase structure allows rational design of hyperactive variants for genetic engineering.

    Science.gov (United States)

    Voigt, Franka; Wiedemann, Lisa; Zuliani, Cecilia; Querques, Irma; Sebe, Attila; Mátés, Lajos; Izsvák, Zsuzsanna; Ivics, Zoltán; Barabas, Orsolya

    2016-03-30

    Sleeping Beauty (SB) is a prominent Tc1/mariner superfamily DNA transposon that provides a popular genome engineering tool in a broad range of organisms. It is mobilized by a transposase enzyme that catalyses DNA cleavage and integration at short specific sequences at the transposon ends. To facilitate SB's applications, here we determine the crystal structure of the transposase catalytic domain and use it to model the SB transposase/transposon end/target DNA complex. Together with biochemical and cell-based transposition assays, our structure reveals mechanistic insights into SB transposition and rationalizes previous hyperactive transposase mutations. Moreover, our data enables us to design two additional hyperactive transposase variants. Our work provides a useful resource and proof-of-concept for structure-based engineering of tailored SB transposases.

  17. Neural correlates of beauty.

    Science.gov (United States)

    Kawabata, Hideaki; Zeki, Semir

    2004-04-01

    We have used the technique of functional MRI to address the question of whether there are brain areas that are specifically engaged when subjects view paintings that they consider to be beautiful, regardless of the category of painting (that is whether it is a portrait, a landscape, a still life, or an abstract composition). Prior to scanning, each subject viewed a large number of paintings and classified them into beautiful, neutral, or ugly. They then viewed the same paintings in the scanner. The results show that the perception of different categories of paintings are associated with distinct and specialized visual areas of the brain, that the orbito-frontal cortex is differentially engaged during the perception of beautiful and ugly stimuli, regardless of the category of painting, and that the perception of stimuli as beautiful or ugly mobilizes the motor cortex differentially.

  18. ON BEAUTY AND THE BEAUTIFUL IN AESTHETIC EDUCATION

    Directory of Open Access Journals (Sweden)

    Borce Kostov

    2013-06-01

    Full Text Available We titled our work “On Beauty and the Beautiful in Aesthetic Education” and we analyzed the category beautiful in function of better understanding the issues of aesthetic education.The basic point was the fact that the determination of the term beautiful is being different in both, time aspect and space aspect. Also, the authors involved in this matter have got different understanding on beautiful issue, on its essence, on its role in human development and on the development of the aesthetics and the aesthetic education.Therefore, within our work, there is an attempt to differ the approaches towards the category beautiful, to comment it, to compare it and finally to give our approach.

  19. Beauty Redeemed

    DEFF Research Database (Denmark)

    Braae, Ellen Marie

    /PROAP’s Parque do Tejo e Trancão in Lisbon and Michel Desvigne’s Parc aux Angéliques in Bordeaux. Beauty Redeemed offers a systematic framework for the consideration and use of post-industrial sites. The author, Professor of Landscape Design at Copenhagen University, places these ‘leftovers’ in their broad......; it explores design work informed by a sensibility for redeemed beauty and various concepts of relating past, present and future...

  20. The medicalization of beauty

    Directory of Open Access Journals (Sweden)

    Paulo Poli Neto

    2007-01-01

    Full Text Available Concern with body image and medical interventions related to physical beauty has greatly increased in the past few years. The purpose of this study is to investigate how medicine is dealing with the theme of beauty. The 2003/2004 editions of the periodicals Aesthetic Surgery Journal and Aesthetic Plastic Surgery were analyzed, in order to investigate the rationality buttressing their discourse. Three categories were prioritized for this study: definition of aesthetic plastic surgery's study object; beauty patterns guiding interventions; and understanding popular demand for aesthetic corrections. Discourse is sustained by biomedical rationality, structured around a disease theory and a dual construction between normal and pathological, with emphasis on biology. In the articles, the beauty patterns guiding therapeutic practices are anchored in biological norms defined through several anthropometric measures, which refer to abstract concepts of beauty, harmony, proportionality and symmetry. In this discourse, there are no references to patterns or to social norms of beauty; motivation for aesthetic intervention appears to be rooted in low self-esteem related to the aging process or to some bodily nonconformity. As per the meaning of 'medicalization' adopted herein, biomedical rationality appropriates variations or anomalies of physical appearance, thus allowing the theme to be dealt with in terms of health and disease, normal and pathological.

  1. Open Charm and Beauty Production at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Behnke, Olaf [DESY, Notkestrasse 85, 22607 Hamburg (Germany)

    2012-01-15

    A review is provided of open charm and beauty production at HERA and its description by perturbative QCD (pQCD). Four years after the end of the data taking there is still a steady flow of new charm and beauty results from HERA. Among the results reported here are the first combined H1 and ZEUS measurements on the contribution from charm production to deep inelastic scattering (DIS), represented by the structure function F{sub 2}{sup cc{sup {sup M{sup a{sup c{sup r{sup o{sup n{sup }}}}}}}}}, as well as new precise results on the corresponding structure function for beauty production, F{sub 2}{sup bb{sup {sup M{sup a{sup c{sup r{sup o{sup n{sup }}}}}}}}}. Furthermore the situation of charm and beauty production in the photoproduction kinematic regime is reviewed. Since it is a related field also the first hadroproduction results from LHC are presented. A brief outlook is given on open heavy flavour prospects at possible future ep colliders, with a focus on the LHeC.

  2. Measurement of beauty production in DIS and extraction at ZEUS

    Energy Technology Data Exchange (ETDEWEB)

    Abramowicz, H.; Ingbir, R.; Kananov, S.; Levy, A.; Stern, A. [Tel Aviv University, Raymond and Beverly Sackler Faculty of Exact Sciences, School of Physics, Tel Aviv (Israel); Abt, I.; Caldwell, A.; Kollar, D.; Reisert, B.; Schmidke, W.B. [Max-Planck-Institut fuer Physik, Muenchen (Germany); Adamczyk, L.; Bold, T.; Gach, G.; Grabowska-Bold, I.; Kisielewska, D.; Przybycien, M.; Suszycki, L. [AGH-University of Science and Technology, Faculty of Physics and Applied Computer Science, Cracow (Poland); Adamus, M.; Plucinski, P.; Tymieniecka, T. [Institute for Nuclear Studies, Warsaw (Poland); Aggarwal, R.; Kaur, M.; Kaur, P.; Singh, I. [Panjab University, Department of Physics, Chandigarh (India); Antonelli, S.; Basile, M.; Bindi, M.; Cifarelli, L.; Contin, A.; De Pasquale, S.; Sartorelli, G.; Zichichi, A. [University Bologna (Italy); INFN Bologna, Bologna (Italy); Antonioli, P.; Bari, G.; Bellagamba, L.; Boscherini, D.; Bruni, A.; Bruni, G.; Cindolo, F.; Corradi, M.; Iacobucci, G.; Margotti, A.; Nania, R.; Polini, A. [INFN Bologna, Bologna (Italy); Antonov, A.; Dolgoshein, B.A.; Gladkov, D.; Sosnovtsev, V.; Stifutkin, A.; Suchkov, S. [Moscow Engineering Physics Institute, Moscow (Russian Federation); Arneodo, M.; Ruspa, M. [Universita del Piemonte Orientale, Novara (Italy); INFN, Torino (Italy); Aushev, V.; Aushev, Y.; Borodin, M.; Gogota, O.; Kadenko, I.; Korol, I.; Kuprash, O.; Lontkovskyi, D.; Makarenko, I.; Onishchuk, Yu.; Salii, A.; Tomalak, O.; Viazlo, V.; Volynets, O.; Zenaiev, O.; Zhmak, N.; Zolko, M. [National Academy of Sciences, and Kiev National University, Institute for Nuclear Research, Kiev (Ukraine); Bachynska, O.; Behnke, O.; Behr, J.; Behrens, U.; Blohm, C.; Borras, K.; Bot, D.; Ciesielski, R.; Coppola, N.; Fang, S.; Geiser, A.; Goettlicher, P.; Grebenyuk, J.; Gregor, I.; Haas, T.; Hain, W.; Huettmann, A.; Januschek, F.; Kahle, B.; Katkov, I.I.; Klein, U.; Koetz, U.; Kowalski, H.; Libov, V.; Lisovyi, M.; Lobodzinska, E. [and others

    2010-10-15

    Beauty production in deep inelastic scattering with events in which a muon and a jet are observed in the final state has been measured with the ZEUS detector at HERA using an integrated luminosity of 114 pb{sup -1}. The fraction of events with beauty quarks in the data was determined using the distribution of the transverse momentum of the muon relative to the jet. The cross section for beauty production was measured in the kinematic range of photon virtuality, Q{sup 2}>2 GeV{sup 2}, and inelasticity, 0.05beauty contribution to the structure function F{sub 2} was extracted and is compared to theoretical predictions. (orig.)

  3. Beautiful Flowers

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    春天到了,百花盛开,我们常说“美丽的鲜花”,就是:beautiful flowers。是不是觉得这两个单词有点儿难记呢?没关系,来玩玩我们的进宫吧,它能帮助你牢牢记住这两个单词的拼法。

  4. BEAUTIFUL, SENSE OF BEAUTY AND ELEMENTS OF BEAUTY IN TURKISH “MÂNİ”

    Directory of Open Access Journals (Sweden)

    Bülent Kahraman Çolakoğlu

    2014-08-01

    Full Text Available This study underlines the “mâni” which represents anonymous folk literature reflecting Turkish cultural life. Turkish nation’s sense of beautiful and beauty, the elements of beauty which belong to beauty/beloved have been studied with reference to Turkish “mâni” in order to protect Turkish cultural treasures and ensure them to be inherited from generation to generation by functionalizing them. In the study, content analysis has been used in the process of data interpretation. 4068 “mâni”s which are in the source tagged with “Demir, Necati (2013, Türk Mânileri, Ankara: Gazi Kitabevi” have been examined and they have been analyzed and assessed in line with the predetermined purpose. With this study, it is consolidated that the Turks have always had advanced sense of beauty; they have always been a nation who has a taste for beauty and taste and sense of aesthetic since the old historical periods. It is observed that the poetic themes of hair, eyebrow, eyelash, eye, beauty spot, cheek-dimple, face, cheek-dewlap, waist, heel, skin, age, speech, smile, smell, jewellery/ornament, deportment, coquetry/manner/affection are used as elements of beauty in Turkish “mâni”.

  5. Is moral beauty different from facial beauty? Evidence from an fMRI study.

    Science.gov (United States)

    Wang, Tingting; Mo, Lei; Mo, Ce; Tan, Li Hai; Cant, Jonathan S; Zhong, Luojin; Cupchik, Gerald

    2015-06-01

    Is moral beauty different from facial beauty? Two functional magnetic resonance imaging experiments were performed to answer this question. Experiment 1 investigated the network of moral aesthetic judgments and facial aesthetic judgments. Participants performed aesthetic judgments and gender judgments on both faces and scenes containing moral acts. The conjunction analysis of the contrasts 'facial aesthetic judgment > facial gender judgment' and 'scene moral aesthetic judgment > scene gender judgment' identified the common involvement of the orbitofrontal cortex (OFC), inferior temporal gyrus and medial superior frontal gyrus, suggesting that both types of aesthetic judgments are based on the orchestration of perceptual, emotional and cognitive components. Experiment 2 examined the network of facial beauty and moral beauty during implicit perception. Participants performed a non-aesthetic judgment task on both faces (beautiful vs common) and scenes (containing morally beautiful vs neutral information). We observed that facial beauty (beautiful faces > common faces) involved both the cortical reward region OFC and the subcortical reward region putamen, whereas moral beauty (moral beauty scenes > moral neutral scenes) only involved the OFC. Moreover, compared with facial beauty, moral beauty spanned a larger-scale cortical network, indicating more advanced and complex cerebral representations characterizing moral beauty.

  6. Is moral beauty different from facial beauty? Evidence from an fMRI study

    Science.gov (United States)

    Wang, Tingting; Mo, Ce; Tan, Li Hai; Cant, Jonathan S.; Zhong, Luojin; Cupchik, Gerald

    2015-01-01

    Is moral beauty different from facial beauty? Two functional magnetic resonance imaging experiments were performed to answer this question. Experiment 1 investigated the network of moral aesthetic judgments and facial aesthetic judgments. Participants performed aesthetic judgments and gender judgments on both faces and scenes containing moral acts. The conjunction analysis of the contrasts ‘facial aesthetic judgment > facial gender judgment’ and ‘scene moral aesthetic judgment > scene gender judgment’ identified the common involvement of the orbitofrontal cortex (OFC), inferior temporal gyrus and medial superior frontal gyrus, suggesting that both types of aesthetic judgments are based on the orchestration of perceptual, emotional and cognitive components. Experiment 2 examined the network of facial beauty and moral beauty during implicit perception. Participants performed a non-aesthetic judgment task on both faces (beautiful vs common) and scenes (containing morally beautiful vs neutral information). We observed that facial beauty (beautiful faces > common faces) involved both the cortical reward region OFC and the subcortical reward region putamen, whereas moral beauty (moral beauty scenes > moral neutral scenes) only involved the OFC. Moreover, compared with facial beauty, moral beauty spanned a larger-scale cortical network, indicating more advanced and complex cerebral representations characterizing moral beauty. PMID:25298010

  7. Beautiful geometry

    CERN Document Server

    Maor, Eli

    2014-01-01

    If you've ever thought that mathematics and art don't mix, this stunning visual history of geometry will change your mind. As much a work of art as a book about mathematics, Beautiful Geometry presents more than sixty exquisite color plates illustrating a wide range of geometric patterns and theorems, accompanied by brief accounts of the fascinating history and people behind each. With artwork by Swiss artist Eugen Jost and text by acclaimed math historian Eli Maor, this unique celebration of geometry covers numerous subjects, from straightedge-and-compass constructions to intriguing configur

  8. CULTURE-SPECIFIC CONCEPTUALISATIONS OF BEAUTY

    OpenAIRE

    Харлай, О. В.

    2017-01-01

    From the perspective of cultural linguistics, this paper a) investigates and compares the conceptualisations of beauty in the Chinese, English and Slavonic (Polish and Ukrainian), b) analyses the cultural contexts of in which beauty conceptualises and c) reveals the crucial peculiarities of the human’s perception and evaluation of beauty in the appointed languages. Based on the theory that language is an activity the character and structure of which express the culture and individuality of sp...

  9. Beauty and critical art: is beauty at odds with critical–political engagement?

    Directory of Open Access Journals (Sweden)

    Maria-Alina Asavei

    2015-06-01

    Full Text Available Traditionally, beauty is understood as an ability of some objects (artworks included to occasion in viewers a distinctive type of unmediated/pure pleasure—aesthetic pleasure. According to this common understanding of beauty, political–critical art does not seem to raise in viewers the feeling of aesthetic pleasure. Many contemporary critical artists and politically engaged artists deliberately produce an art as unappealing to the senses as possible (their attitude could be called, following Arthur Danto, kalliphobia—“beauty phobia”. Critical art is a type of art which usually does not strike us with beauty at first sight because this “political art” usually deals with issues of social injustice and political struggles, rendering contemplation and aesthetic pure pleasure unachievable. Yet, even if beauty, in critical art's case, seems to be a difficult, demanding, and not an immediately recognisable one (mostly because of its unappealing, unsettling look, this does not mean that it lacks or is at odds with critical engagement (as some critical artists and theorists have argued. The argument of this paper is that not every beautiful thing looks good at first sight. By the same token, not everything that looks beautiful is in fact beautiful. Drawing on Immanuel Kant's neglected pulchritude adhaerens (dependent beauty, I argue that political–critical art is characterised by a dependent type of beauty (beauty a thing has as a thing of a certain kind and with a certain function as opposed to free beauty (as something we like it freely on its own account, independent of what it is and what it does. Political–critical art can claim a dependent beauty (an impure, “difficult” and not straightforward pleasurable type of beauty without being compelled to submit itself, at the same time, to the free beauty.

  10. Perceiving beauty in all women: Psychometric evaluation of the Broad Conceptualization of Beauty Scale.

    Science.gov (United States)

    Tylka, Tracy L; Iannantuono, Amy C

    2016-06-01

    Women's ability to broadly conceptualize beauty (i.e., perceive many looks, appearances, body sizes/shapes, and inner characteristics as beautiful) has been identified as a facet of positive body image in qualitative research. A scale is needed to be able to assess this construct within quantitative research. Therefore, we developed the Broad Conceptualization of Beauty Scale (BCBS), which measures the extent women define female beauty widely within external and internal characteristics, and examined its psychometric properties among four community samples totaling 1086 women. Exploratory and confirmatory factor analyses revealed a unidimensional structure with nine items. The internal consistency, test-retest reliability, and construct (convergent, discriminant, and incremental) validity of its scores were upheld. Researchers and clinicians can use the BCBS alone to assess women's perceptions of female beauty, or they can use the BCBS alongside women's perceptions of self-beauty to more comprehensively explore women's ability to broadly conceptualize beauty for others and themselves.

  11. Concerning Olga, the Beautiful Little Street Dancer (Adjectives as Higher-Order Polymorphic Functions)

    CERN Document Server

    Saba, Walid S

    2008-01-01

    In this paper we suggest a typed compositional seman-tics for nominal compounds of the form [Adj Noun] that models adjectives as higher-order polymorphic functions, and where types are assumed to represent concepts in an ontology that reflects our commonsense view of the world and the way we talk about it in or-dinary language. In addition to [Adj Noun] compounds our proposal seems also to suggest a plausible explana-tion for well known adjective ordering restrictions.

  12. Charm and Beauty Production from Secondary Vertexing at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Thompson, Paul [University of Birmingham, Edgbaston, Birmingham, B15 2TT (United Kingdom)

    2010-07-01

    Measurement of the Charm and Beauty Structure Functions using the H1 Vertex Detector at HERA Inclusive charm and beauty cross sections are measured in e{sup -} p and e{sup +}p neutral current collisions at HERA in the kinematic region of photon virtuality 5 < Q{sup 2} < 2000 GeV{sup 2} and Bjorken scaling variable 0.0002 < x < 0.05. The data were collected with the H1 detector in the years 2006 and 2007 corresponding to an integrated luminosity of 189 pb{sup -1}. The numbers of charm and beauty events are determined using variables reconstructed by the H1 vertex detector including the impact parameter of tracks to the primary vertex and the position of the secondary vertex. The measurements are combined with previous data and compared to QCD predictions. Measurement of Charm and Beauty Jets in Deep Inelastic Scattering at HERA Measurements of the charm and beauty jet cross sections have been made in deep inelastic scattering at HERA for the kinematic region of photon virtuality Q{sup 2} > 6 GeV{sup 2} and elasticity variable 0.07 < y < 0.625 for jets in the laboratory frame with transverse energy E{sub T}{sup jet} > 6 GeV and pseudorapidity -1.0 < {eta}{sup jet} < 1.5. Measurements are also made requiring a jet in the Breit frame with E{sub T}{sup jet} > 6 GeV. The data were collected with the H1 detector in the years 2006 and 2007 corresponding to an integrated luminosity of 189 pb{sup -1}. The number of charm and beauty jets are determined using variables reconstructed by the H1 vertex detector including the impact parameter of tracks to the primary vertex and the position of the secondary vertex. The measurements are compared with QCD predictions and with previous measurements obtained using muon tagging. Charm and beauty production in deep inelastic scattering from inclusive secondary vertexing at ZEUS Charm and beauty production in deep inelastic scattering has been measured with the ZEUS detector using the full HERA II data set. The charm and beauty contents

  13. Structure function monitor

    Energy Technology Data Exchange (ETDEWEB)

    McGraw, John T [Placitas, NM; Zimmer, Peter C [Albuquerque, NM; Ackermann, Mark R [Albuquerque, NM

    2012-01-24

    Methods and apparatus for a structure function monitor provide for generation of parameters characterizing a refractive medium. In an embodiment, a structure function monitor acquires images of a pupil plane and an image plane and, from these images, retrieves the phase over an aperture, unwraps the retrieved phase, and analyzes the unwrapped retrieved phase. In an embodiment, analysis yields atmospheric parameters measured at spatial scales from zero to the diameter of a telescope used to collect light from a source.

  14. Purely Functional Structured Programming

    OpenAIRE

    Obua, Steven

    2010-01-01

    The idea of functional programming has played a big role in shaping today's landscape of mainstream programming languages. Another concept that dominates the current programming style is Dijkstra's structured programming. Both concepts have been successfully married, for example in the programming language Scala. This paper proposes how the same can be achieved for structured programming and PURELY functional programming via the notion of LINEAR SCOPE. One advantage of this proposal is that m...

  15. Measurement of beauty production in deep inelastic scattering at HERA using decays into electrons

    CERN Document Server

    Abramowicz, H; Adamczyk, L; Adamus, M; Aggarwal, R; Antonelli, S; Antonioli, P; Antonov, A; Arneodo, M; Aushev, V; Aushev, Y; Bachynska, O; Bamberger, A; Barakbaev, A N; Barbagli, G; Bari, G; Barreiro, F; Bartosik, N; Bartsch, D; Basile, M; Behnke, O; Behr, J; Behrens, U; Bellagamba, L; Bertolin, A; Bhadra, S; Bindi, M; Blohm, C; Bokhonov, V; Bołd, T; Bolilyi, O; Boos, E G; Borras, K; Boscherini, D; Bot, D; Boutle, S K; Brock, I; Brownson, E; Brugnera, R; Brümmer, N; Bruni, A; Bruni, G; Brzozowska, B; Bussey, P J; Butterworth, J M; Bylsma, B; Caldwell, A; Capua, M; Carlin, R; Catterall, C D; Chekanov, S; Chwastowski, J; Ciborowski, J; Ciesielski, R; Cifarelli, L; Cindolo, F; Contin, A; Cooper-Sarkar, A M; Coppola, N; Corradi, M; Corriveau, F; Costa, M; D'Agostini, G; Corso, F Dal; del Peso, J; Dementiev, R K; De Pasquale, S; Derrick, M; Devenish, R C E; Dobur, D; Dolgoshein, B A; Dolinska, G; Doyle, A T; Drugakov, V; Durkin, L S; Dusini, S; Eisenberg, Y; Ermolov, P F; Eskreys, A; Fang, S; Fazio, S; Ferrando, J; Ferrero, M I; Figiel, J; Forrest, M; Foster, B; Fourletov, S; Gach, G; Galas, A; Gallo, E; Garfagnini, A; Geiser, A; Gialas, I; Gladilin, L K; Gladkov, D; Glasman, C; Gogota, O; Golubkov, Yu A; Göttlicher, P; Grabowska-Bołd, I; Grebenyuk, J; Gregor, I; Grigorescu, G; Grzelak, G; Gueta, O; Gwenlan, C; Haas, T; Hain, W; Hamatsu, R; Hart, J C; Hartmann, H; Hartner, G; Hilger, E; Hochman, D; Hori, R; Horton, K; Hüttmann, A; Iacobucci, G; Ibrahim, Z A; Iga, Y; Ingbir, R; Ishitsuka, M; Jakob, H -P; Januschek, F; Jimenez, M; Jones, T W; Jüngst, M; Kadenko, I; Kahle, B; Kamaluddin, B; Kananov, S; Kanno, T; Karshon, U; Karstens, F; Katkov, I I; Kaur, M; Kaur, P; Keramidas, A; Khein, L A; Kim, J Y; Kisielewska, D; Kitamura, S; Klanner, R; Klein, U; Koffeman, E; Kooijman, P; Korol, Ie; Korzhavina, I A; Kotański, A; Kötz, U; Kowalski, H; Kulinski, P; Kuprash, O; Kuze, M; Lee, A; Levchenko, B B; Levy, A; Libov, V; Limentani, S; Ling, T Y; Lisovyi, M; Lobodzinska, E; Lohmann, W; Löhr, B; Lohrmann, E; Loizides, J H; Long, K R; Longhin, A; Lontkovskyi, D; Lukina, O Yu; Łużniak, P; Maeda, J; Magill, S; Makarenko, I; Malka, J; Mankel, R; Margotti, A; Marini, G; Martin, J F; Mastroberardino, A; Mattingly, M C K; Melzer-Pellmann, I -A; Mergelmeyer, S; Miglioranzi, S; Idris, F Mohamad; Monaco, V; Montanari, A; Morris, J D; Mujkic, K; Musgrave, B; Nagano, K; Namsoo, T; Nania, R; Nicholass, D; Nigro, A; Ning, Y; Noor, U; Notz, D; Nowak, R J; Nuncio-Quiroz, A E; Oh, B Y; Okazaki, N; Oliver, K; Olkiewicz, K; Onishchuk, Yu; Papageorgiu, K; Parenti, A; Paul, E; Pawlak, J M; Pawlik, B; Pelfer, P G; Pellegrino, A; Perlanski, W; Perrey, H; Piotrzkowski, K; Plucinski, P; Pokrovskiy, N S; Polini, A; Proskuryakov, A S; Przybycień, M; Raval, A; Reeder, D D; Reisert, B; Ren, Z; Repond, J; Ri, Y D; Robertson, A; Roloff, P; Ron, E; Rubinsky, I; Ruspa, M; Sacchi, R; Salii, A; Samson, U; Sartorelli, G; Savin, A A; Saxon, D H; Schioppa, M; Schlenstedt, S; Schleper, P; Schmidke, W B; Schneekloth, U; Schönberg, V; Schörner-Sadenius, T; Schwartz, J; Sciulli, F; Shcheglova, L M; Shehzadi, R; Shimizu, S; Singh, I; Skillicorn, I O; Słomiński, W; Smith, W H; Sola, V; Solano, A; Son, D; Sosnovtsev, V; Spiridonov, A; Stadie, H; Stanco, L; Stern, A; Stewart, T P; Stifutkin, A; Stopa, P; Suchkov, S; Susinno, G; Suszycki, L; Sztuk-Dambietz, J; Szuba, D; Szuba, J; Tapper, A D; Tassi, E; Terrón, J; Theedt, T; Tiecke, H; Tokushuku, K; Tomalak, O; Tomaszewska, J; Tsurugai, T; Turcato, M; Tymieniecka, T; Uribe-Estrada, C; Vázquez, M; Verbytskyi, A; Viazlo, O; Vlasov, N N; Volynets, O; Walczak, R; Abdullah, W A T Wan; Whitmore, J J; Whyte, J; Wiggers, L; Wing, M; Wlasenko, M; Wolf, G; Wolfe, H; Wrona, K; Yagües-Molina, A G; Yamada, S; Yamazaki, Y; Yoshida, R; Youngman, C; Żarnecki, A F; Zawiejski, L; Zenaiev, O; Zeuner, W; Zhautykov, B O; Zhmak, N; Zhou, C; Zichichi, A; Zolko, M; Zotkin, D S; Zulkapli, Z

    2011-01-01

    The production of beauty quarks in ep interactions has been studied with the ZEUS detector at HERA for exchanged four-momentum squared Q^2 > 10 GeV^2, using an integrated luminosity of 363 pb^{-1}. The beauty events were identified using electrons from semileptonic b decays with a transverse momentum 0.9 < p_T^e < 8 GeV and pseudorapidity |eta^e| < 1.5. Cross sections for beauty production were measured and compared with next-to-leading-order QCD calculations. The beauty contribution to the proton structure function F_2 was extracted from the double-differential cross section as a function of Bjorken-x and Q^2.

  16. Measurement of beauty production in deep inelastic scattering at HERA using decays into electrons

    Energy Technology Data Exchange (ETDEWEB)

    Abramowicz, H.; Gueta, O.; Ingbir, R.; Kananov, S.; Levy, A.; Stern, A. [Tel Aviv Univ., Raymond and Beverly Sackler Faculty of Exact Sciences, School of Physics, Tel Aviv (Israel); Abt, I.; Caldwell, A.; Reisert, B.; Schmidke, W.B. [Max-Planck-Inst. fuer Physik, Muenchen (Germany); Adamczyk, L.; Bold, T.; Gach, G.; Grabowska-Bold, I.; Kisielewska, D.; Przybycien, M.; Suszycki, L. [AGH-Univ. of Science and Technology, Faculty of Physics and Applied Computer Science, Cracow (Poland); Adamus, M.; Plucinski, P.; Tymieniecka, T. [Inst. for Nuclear Studies, Warsaw (Poland); Aggarwal, R.; Kaur, M.; Kaur, P.; Singh, I. [Panjab Univ., Dept. of Physics, Chandigarh (India); Antonelli, S.; Basile, M.; Bindi, M.; Cifarelli, L.; Contin, A.; De Pasquale, S.; Sartorelli, G.; Zichichi, A. [Univ. Bologna (Italy); INFN Bologna (Italy); Antonioli, P.; Bari, G.; Bellagamba, L.; Boscherini, D.; Bruni, A.; Bruni, G.; Cindolo, F.; Corradi, M.; Iacobucci, G.; Margotti, A.; Nania, R.; Polini, A. [INFN Bologna (Italy); Antonov, A.; Dolgoshein, B.A.; Gladkov, D.; Sosnovtsev, V.; Stifutkin, A.; Suchkov, S. [Moscow Engineering Physics Inst., Moscow (Russian Federation); Arneodo, M.; Ruspa, M. [Univ. del Piemonte Orientale, Novara (Italy); INFN, Torino (Italy); Aushev, V.; Dolinska, G.; Gogota, O.; Korol, I.; Viazlo, O. [National Academy of Sciences, Inst. for Nuclear Research, Kyiv (Ukraine); National Taras Shevchenko Univ. of Kyiv, Dept. of Nuclear Physics, Kyiv (Ukraine); Aushev, Y.; Bartosik, N.; Bolilyi, O.; Kadenko, I.; Kuprash, O.; Lontkovskyi, D.; Makarenko, I.; Onishchuk, Y.; Salii, A.; Tomalak, O.; Volynets, O.; Zenaiev, O.; Zolko, M. [National Taras Shevchenko Univ. of Kyiv, Dept. of Nuclear Physics, Kyiv (Ukraine); Bachynska, O.; Behnke, O.; Behr, J.; Behrens, U.; Blohm, C.; Borras, K.; Bot, D.; Ciesielski, R.; Coppola, N.; Fang, S.; Geiser, A.; Goettlicher, P.; Grebenyuk, J.; Gregor, I.; Haas, T.; Hain, W.; Huettmann, A.; Januschek, F.; Kahle, B. [and others

    2011-02-15

    The production of beauty quarks in ep interactions has been studied with the ZEUS detector at HERA for exchanged four-momentum squared Q{sup 2}>10 GeV{sup 2}, using an integrated luminosity of 363 pb{sup -1}. The beauty events were identified using electrons from semileptonic b decays with a transverse momentum 0.9beauty production were measured and compared with next-to-leading-order QCD calculations. The beauty contribution to the proton structure function F{sub 2} was extracted from the double-differential cross section as a function of Bjorken-x and Q{sup 2}. (orig.)

  17. Measurement of beauty production in deep inelastic scattering at HERA using decays into electrons

    Energy Technology Data Exchange (ETDEWEB)

    Shehzadi, Ramoona

    2011-01-15

    The production of beauty quarks in ep interactions has been studied with the ZEUS detector at HERA for exchanged four-momentum squared Q{sup 2}>10 GeV{sup 2}, using an integrated luminosity of 363 pb{sup -1}. The beauty events were identified using electrons from semileptonic b decays with a transverse momentum 0.9beauty production were measured and compared with next-to-leading-order QCD calculations. The beauty contribution to the proton structure function F{sub 2} was extracted from the double-differential cross section as a function of Bjorken-x and Q{sup 2}. (orig.)

  18. Measurement of beauty production in deep inelastic scattering at HERA using decays into electrons

    Energy Technology Data Exchange (ETDEWEB)

    Abramowicz, H. [Tel Aviv Univ. (Israel). School of Physics; Max-Planck-Institut fuer Physik, Muenchen (Germany); Abt, I. [Max-Planck-Institut fuer Physik, Muenchen (Germany); Adamczyk, L. [AGH-Univ. of Science and Technology, Cracow (PL). Faculty of Physics and Applied Computer Science] (and others)

    2011-01-15

    The production of beauty quarks in ep interactions has been studied with the ZEUS detector at HERA for exchanged four-momentum squared Q{sup 2}>10 GeV{sup 2}, using an integrated luminosity of 363 pb{sup -1}. The beauty events were identified using electrons from semileptonic b decays with a transverse momentum 0.9 beauty production were measured and compared with next-to-leading-order QCD calculations. The beauty contribution to the proton structure function F{sub 2} was extracted from the double-differential cross section as a function of Bjorken-x and Q{sup 2}. (orig.)

  19. Chromatin Structure and Function

    CERN Document Server

    Wolffe, Alan P

    1999-01-01

    The Third Edition of Chromatin: Structure and Function brings the reader up-to-date with the remarkable progress in chromatin research over the past three years. It has been extensively rewritten to cover new material on chromatin remodeling, histone modification, nuclear compartmentalization, DNA methylation, and transcriptional co-activators and co-repressors. The book is written in a clear and concise fashion, with 60 new illustrations. Chromatin: Structure and Function provides the reader with a concise and coherent account of the nature, structure, and assembly of chromatin and its active

  20. The small and the beautiful: How the star formation law affects galactic disk structure

    CERN Document Server

    Braun, Harald

    2015-01-01

    We investigate the influence of different analytical parameterizations and fit functions for the local star formation rate in AMR simulations of an isolated disk galaxy with the Nyx code. Such parameterizations express the star formation efficiency as function of the local turbulent Mach number and viral parameter. By employing the method of adaptively refined large eddy simulations, we are able to evaluate these physical parameters from the numerically unresolved turbulent energy associated with the grid scale. We consider both single and multi free-fall variants of star formation laws proposed by Padoan & Nordlund, Hennebelle & Chabrier, and Krumholz & McKee. We find that the global star formation rate and the relation between the local star formation rate and the gas column density is reproduced in agreement with observational constraints by all multi free-fall models of star formation. Some models with obsolete calibration or a single free-fall time scale, however, result in an overly clumpy d...

  1. The Real Beauty

    Institute of Scientific and Technical Information of China (English)

    胡晓媛

    2015-01-01

    it is well-known that all men search for beauty. Although the definition of beauty changes as time goes by,people still spare no efforts to pursue beauty in their lives. Meanwhile,most people try every means to make their body images better.With more people increasingly being eager for beauty in various ways,it is high time that we should think deeply about the concept of real beauty.Inthis paper,an attempt has been made to shed light on the real beauty.It is not completely physical appearance or slim figure,but a healthy body and peaceful mind as well as admirable courage.Above all,whether people can realize the nature of real beauty is certainly worthwhile for us to ponder.

  2. The Real Beauty

    Institute of Scientific and Technical Information of China (English)

    胡晓媛

    2015-01-01

    it is well-known that all men search for beauty.Although the definition of beauty changes as time goes by,people still spare no efforts to pursue beauty in their lives.Meanwhile,most people try every means to make their body images better.With more people increasingly being eager for beauty in various ways,it is high time that we should think deeply about the concept of real beauty.In this paper,an attempt has been made to shed light on the real beauty.It is not completely physical appearance or slim figure,but a healthy body and peaceful mind as well as admirable courage.Above all,whether people can realize the nature of real beauty is certainly worthwhile for us to ponder.

  3. Measurement of beauty production in DIS and F_2^bbbar extraction at ZEUS

    CERN Document Server

    Abramowicz, H; Adamczyk, L; Adamus, M; Aggarwal, R; Antonelli, S; Antonioli, P; Antonov, A; Arneodo, M; Aushev, V; Aushev, Y; Bachynska, O; Bamberger, A; Barakbaev, A N; Barbagli, G; Bari, G; Barreiro, F; Bartsch, D; Basile, M; Behnke, O; Behr, J; Behrens, U; Bellagamba, L; Bertolin, A; Bhadra, S; Bindi, M; Blohm, C; Bold, T; Boos, E G; Borodin, M; Borras, K; Boscherini, D; Bot, D; Boutle, S K; Brock, I; Brownson, E; Brugnera, R; Bruemmer, N; Bruni, A; Bruni, G; Brzozowska, B; Bussey, P J; Butterworth, J M; Bylsma, B; Caldwell, A; Capua, M; Carlin, R; Catterall, C D; Chekanov, S; Chwastowski, J; Ciborowski, J; Ciesielski, R; Cifarelli, L; Cindolo, F; Contin, A; Cooper-Sarkar, A M; Coppola, N; Corradi, M; Corriveau, F; Costa, M; D'Agostini, G; Corso, F Dal; de Favereau, J; del Peso, J; Dementiev, R K; De Pasquale, S; Derrick, M; Devenish, R C E; Dobur, D; Dolgoshein, B A; Doyle, A T; Drugakov, V; Durkin, L S; Dusini, S; Eisenberg, Y; Ermolov, P F; Eskreys, A; Fang, S; Fazio, S; Ferrando, J; Ferrero, M I; Figiel, J; Forrest, M; Foster, B; Fourletov, S; Gach, G; Galas, A; Gallo, E; Garfagnini, A; Geiser, A; Gialas, I; Gladilin, L K; Gladkov, D; Glasman, C; Gogota, O; Golubkov, Yu A; Goettlicher, P; Grabowska-Bold, I; Grebenyuk, J; Gregor, I; Grigorescu, G; Grzelak, G; Gwenlan, C; Haas, T; Hain, W; Hamatsu, R; Hart, J C; Hartmann, H; Hartner, G; Hilger, E; Hochman, D; Holm, U; Hori, R; Horton, K; Huettmann, A; Iacobucci, G; Ibrahim, Z A; Iga, Y; Ingbir, R; Ishitsuka, M; Jakob, H -P; Januschek, F; Jimenez, M; Jones, T W; Juengst, M; Kadenko, I; Kahle, B; Kamaluddin, B; Kananov, S; Kanno, T; Karshon, U; Karstens, F; Katkov, I I; Kaur, M; Kaur, P; Keramidas, A; Khein, L A; Kim, J Y; Kisielewska, D; Kitamura, S; Klanner, R; Klein, U; Koffeman, E; Kollar, D; Kooijman, P; Korol, Ie; Korzhavina, I A; Kotanski, A; Koetz, U; Kowalski, H; Kulinski, P; Kuprash, O; Kuze, M; Kuzmin, V A; Lee, A; Levchenko, B B; Levy, A; Libov, V; Limentani, S; Ling, T Y; Lisovyi, M; Lobodzinska, E; Lohmann, W; Loehr, B; Lohrmann, E; Loizides, J H; Long, K R; Longhin, A; Lontkovskyi, D; Lukina, O Yu; Luzniak, P; Maeda, J; Magill, S; Makarenko, I; Malka, J; Mankel, R; Margotti, A; Marini, G; Martin, J F; Mastroberardino, A; Matsumoto, T; Mattingly, M C K; Melzer-Pellmann, I -A; Miglioranzi, S; Idris, F Mohamad; Monaco, V; Montanari, A; Morris, J D; Musgrave, B; Nagano, K; Namsoo, T; Nania, R; Nicholass, D; Nigro, A; Ning, Y; Noor, U; Notz, D; Nowak, R J; Nuncio-Quiroz, A E; Oh, B Y; Okazaki, N; Oliver, K; Olkiewicz, K; Onishchuk, Yu; Ota, O; Papageorgiu, K; Parenti, A; Paul, E; Pawlak, J M; Pawlik, B; Pelfer, P G; Pellegrino, A; Perlanski, W; Perrey, H; Piotrzkowski, K; Plucinski, P; Pokrovskiy, N S; Polini, A; Proskuryakov, A S; Przybycien, M; Raval, A; Reeder, D D; Reisert, B; Ren, Z; Repond, J; Ri, Y D; Robertson, A; Roloff, P; Ron, E; Rubinsky, I; Ruspa, M; Sacchi, R; Salii, A; Samson, U; Sartorelli, G; Savin, A A; Saxon, D H; Schioppa, M; Schlenstedt, S; Schleper, P; Schmidke, W B; Schneekloth, U; Schoenberg, V; Schoerner-Sadenius, T; Schwartz, J; Sciulli, F; Shcheglova, L M; Shehzadi, R; Shimizu, S; Singh, I; Skillicorn, I O; Slominski, W; Smith, W H; Sola, V; Solano, A; Son, D; Sosnovtsev, V; Spiridonov, A; Stadie, H; Stanco, L; Stern, A; Stewart, T P; Stifutkin, A; Stopa, P; Suchkov, S; Susinno, G; Suszycki, L; Sztuk, J; Szuba, D; Szuba, J; Tapper, A D; Tassi, E; Terron, J; Theedt, T; Tiecke, H; Tokushuku, K; Tomalak, O; Tomaszewska, J; Tsurugai, T; Turcato, M; Tymieniecka, T; Uribe-Estrada, C; Vazquez, M; Verbytskyi, A; Viazlo, V; Vlasov, N N; Volynets, O; Walczak, R; Abdullah, W A T Wan; Whitmore, J J; Whyte, J; Wiggers, L; Wing, M; Wlasenko, M; Wolf, G; Wolfe, H; Wrona, K; Yagues-Molina, A G; Yamada, S; Yamazaki, Y; Yoshida, R; Youngman, C; Zarnecki, A F; Zawiejski, L; Zenaiev, O; Zeuner, W; Zhautykov, B O; Zhmak, N; Zhou, C; Zichichi, A; Zolko, M; Zotkin, D S; Zulkapli, Z

    2010-01-01

    Beauty production in deep inelastic scattering with events in which a muon and a jet are observed in the final state has been measured with the ZEUS detector at HERA using an integrated luminosity of 114 pb^-1. The fraction of events with beauty quarks in the data was determined using the distribution of the transverse momentum of the muon relative to the jet. The cross section for beauty production was measured in the kinematic range of photon virtuality, Q^2 > 2 Gev^2, and inelasticity, 0.05 < y < 0.7, with the requirement of a muon and a jet. Total and differential cross sections are presented and compared to QCD predictions. The beauty contribution to the structure function F_2 was extracted and is compared to theoretical predictions.

  4. Measurement of beauty and charm production in deep inelastic scattering at HERA and measurement of the beauty-quark mass

    CERN Document Server

    Abramowicz, H; Adamczyk, L.; Adamus, M.; Aggarwal, R.; Antonelli, S.; Arslan, O.; Aushev, V.; Aushev, Y.; Bachynska, O.; Barakbaev, A.N.; Bartosik, N.; Behnke, O.; Behr, J.; Behrens, U.; Bertolin, A.; Bhadra, S.; Bloch, I.; Bokhonov, V.; Boos, E.G.; Borras, K.; Brock, I.; Brugnera, R.; Bruni, A.; Brzozowska, B.; Bussey, P.J.; Caldwell, A.; Capua, M.; Catterall, C.D.; Chwastowski, J.; Ciborowski, J.; Ciesielski, R.; Cooper-Sarkar, A.M.; Corradi, M.; Corriveau, F.; D'Agostini, G.; Dementiev, R.K.; Devenish, R.C.E.; Dolinska, G.; Drugakov, V.; Dusini, S.; Ferrando, J.; Figiel, J.; Foster, B.; Gach, G.; Garfagnini, A.; Geiser, A.; Gizhko, A.; Gladilin, L.K.; Gogota, O.; Golubkov, Yu. A.; Grebenyuk, J.; Gregor, I.; Grzelak, G.; Gueta, O.; Guzik, M.; Hain, W.; Hartner, G.; Hochman, D.; Hori, R.; Ibrahim, Z.A.; Iga, Y.; Ishitsuka, M.; Iudin, A.; Januschek, F.; Kadenko, I.; Kananov, S.; Kanno, T.; Karshon, U.; Kaur, M.; Kaur, P.; Khein, L.A.; Kisielewska, D.; Klanner, R.; Klein, U.; Kondrashova, N.; Kononenko, O.; Korol, Ie.; Korzhavina, I.A.; Kotanski, A.; Kotz, U.; Kovalchuk, N.; Kowalski, H.; Kuprash, O.; Kuze, M.; Levchenko, B.B.; Levy, A.; Libov, V.; Limentani, S.; Lisovyi, M.; Lobodzinska, E.; Lohmann, W.; Lohr, B.; Lohrmann, E.; Longhin, A.; Lontkovskyi, D.; Lukina, O.Yu.; Maeda, J.; Makarenko, I.; Malka, J.; Martin, J.F.; Mergelmeyer, S.; Idris, F.Mohamad; Mujkic, K.; Myronenko, V.; Nagano, K.; Nigro, A.; Nobe, T.; Notz, D.; Nowak, R.J.; Olkiewicz, K.; Onishchuk, Yu.; Paul, E.; Perlanski, W.; Perrey, H.; Pokrovskiy, N.S.; Proskuryakov, A.S.; Przybycien, M.; Raval, A.; Roloff, P.; Rubinsky, I.; Ruspa, M.; Samojlov, V.; Saxon, D.H.; Schioppa, M.; Schmidke, W.B.; Schneekloth, U.; Schorner-Sadenius, T.; Schwartz, J.; Shcheglova, L.M.; Shehzadi, R.; Shevchenko, R.; Shkola, O.; Singh, I.; Skillicorn, I.O.; Slominski, W.; Sola, V.; Solano, A.; Spiridonov, A.; Stanco, L.; Stefaniuk, N.; Stern, A.; Stewart, T.P.; Stopa, P.; Sztuk-Dambietz, J.; Szuba, D.; Szuba, J.; Tassi, E.; Temiraliev, T.; Tokushuku, K.; Tomaszewska, J.; Trofymov, A.; Trusov, V.; Tsurugai, T.; Turcato, M.; Turkot, O.; Tymieniecka, T.; Verbytskyi, A.; Viazlo, O.; Walczak, R.; Wan Abdullah, W.A.T.; Wichmann, K.; Wing, M.; Wolf, G.; Yamada, S.; Yamazaki, Y.; Zakharchuk, N.; Zarnecki, A.F.; Zawiejski, L.; Zenaiev, O.; Zhautykov, B.O.; Zhmak, N.; Zotkin, D.S.

    2014-01-01

    The production of beauty and charm quarks in ep interactions has been studied with the ZEUS detector at HERA for exchanged four-momentum squared 5 < Q^2 < 1000 GeV^2 using an integrated luminosity of 354 pb^{-1}. The beauty and charm content in events with at least one jet have been extracted using the invariant mass of charged tracks associated with secondary vertices and the decay-length significance of these vertices. Differential cross sections as a function of Q^2, Bjorken x, jet transverse energy and pseudorapidity were measured and compared with next-to-leading-order QCD calculations. The beauty and charm contributions to the proton structure functions were extracted from the double-differential cross section as a function of x and Q^2. The running beauty-quark mass, m_b at the scale m_b, was determined from a QCD fit at next-to-leading order to HERA data for the first time and found to be 4.07 \\pm 0.14 (fit} ^{+0.01}_{-0.07} (mod.) ^{+0.05}_{-0.00} (param.) ^{+0.08}_{-0.05} (theo) GeV.

  5. Measurement of beauty and charm production in deep inelastic scattering at HERA and measurement of the beauty-quark mass

    Science.gov (United States)

    Abramowicz, H.; Abt, I.; Adamczyk, L.; Adamus, M.; Aggarwal, R.; Antonelli, S.; Arslan, O.; Aushev, V.; Aushev, Y.; Bachynska, O.; Barakbaev, A. N.; Bartosik, N.; Behnke, O.; Behr, J.; Behrens, U.; Bertolin, A.; Bhadra, S.; Bloch, I.; Bokhonov, V.; Boos, E. G.; Borras, K.; Brock, I.; Brugnera, R.; Bruni, A.; Brzozowska, B.; Bussey, P. J.; Caldwell, A.; Capua, M.; Catterall, C. D.; Chwastowski, J.; Ciborowski, J.; Ciesielski, R.; Cooper-Sarkar, A. M.; Corradi, M.; Corriveau, F.; D'Agostini, G.; Dementiev, R. K.; Devenish, R. C. E.; Dolinska, G.; Drugakov, V.; Dusini, S.; Ferrando, J.; Figiel, J.; Foster, B.; Gach, G.; Garfagnini, A.; Geiser, A.; Gizhko, A.; Gladilin, L. K.; Gogota, O.; Golubkov, Yu. A.; Grebenyuk, J.; Gregor, I.; Grzelak, G.; Gueta, O.; Guzik, M.; Hain, W.; Hartner, G.; Hochman, D.; Hori, R.; Ibrahim, Z. A.; Iga, Y.; Ishitsuka, M.; Iudin, A.; Januschek, F.; Kadenko, I.; Kananov, S.; Kanno, T.; Karshon, U.; Kaur, M.; Kaur, P.; Khein, L. A.; Kisielewska, D.; Klanner, R.; Klein, U.; Kondrashova, N.; Kononenko, O.; Korol, Ie.; Korzhavina, I. A.; Kotanski, A.; Kötz, U.; Kovalchuk, N.; Kowalski, H.; Kuprash, O.; Kuze, M.; Levchenko, B. B.; Levy, A.; Libov, V.; Limentani, S.; Lisovyi, M.; Lobodzinska, E.; Lohmann, W.; Löhr, B.; Lohrmann, E.; Longhin, A.; Lontkovskyi, D.; Lukina, O. Yu.; Maeda, J.; Makarenko, I.; Malka, J.; Martin, J. F.; Mergelmeyer, S.; Mohamad Idris, F.; Mujkic, K.; Myronenko, V.; Nagano, K.; Nigro, A.; Nobe, T.; Notz, D.; Nowak, R. J.; Olkiewicz, K.; Onishchuk, Yu.; Paul, E.; Perlanski, W.; Perrey, H.; Pokrovskiy, N. S.; Proskuryakov, A. S.; Przybycien, M.; Raval, A.; Roloff, P.; Rubinsky, I.; Ruspa, M.; Samojlov, V.; Saxon, D. H.; Schioppa, M.; Schmidke, W. B.; Schneekloth, U.; Schörner-Sadenius, T.; Schwartz, J.; Shcheglova, L. M.; Shehzadi, R.; Shevchenko, R.; Shkola, O.; Singh, I.; Skillicorn, I. O.; Slominski, W.; Sola, V.; Solano, A.; Spiridonov, A.; Stanco, L.; Stefaniuk, N.; Stern, A.; Stewart, T. P.; Stopa, P.; Sztuk-Dambietz, J.; Szuba, D.; Szuba, J.; Tassi, E.; Temiraliev, T.; Tokushuku, K.; Tomaszewska, J.; Trofymov, A.; Trusov, V.; Tsurugai, T.; Turcato, M.; Turkot, O.; Tymieniecka, T.; Verbytskyi, A.; Viazlo, O.; Walczak, R.; Wan Abdullah, W. A. T.; Wichmann, K.; Wing, M.; Wolf, G.; Yamada, S.; Yamazaki, Y.; Zakharchuk, N.; Żarnecki, A. F.; Zawiejski, L.; Zenaiev, O.; Zhautykov, B. O.; Zhmak, N.; Zotkin, D. S.

    2014-10-01

    The production of beauty and charm quarks in ep interactions has been studied with the ZEUS detector at HERA for exchanged four-momentum squared 5 < Q 2 < 1000 GeV2 using an integrated luminosity of 354 pb-1. The beauty and charm content in events with at least one jet have been extracted using the invariant mass of charged tracks associated with secondary vertices and the decay-length significance of these vertices. Differential cross sections as a function of Q 2, Bjorken x, jet trans- verse energy and pseudorapidity were measured and compared with next-to-leading-order QCD calculations. The beauty and charm contributions to the proton structure functions were extracted from the double-differential cross section as a function of x and Q 2. The running beauty-quark mass, m b at the scale m b , was determined from a QCD fit at next-to-leading order to HERA data for the first time and found to be m b ( m b ) = 4.07 ± 0.14 (fit){-/0.07 + 0.01}(mod.){-/0.00 + 0.05}(param.){-/0.05 + 0.08}(theo.) GeV.

  6. Measurement of beauty and charm production in deep inelastic scattering at HERA and measurement of the beauty-quark mass

    Energy Technology Data Exchange (ETDEWEB)

    Abramowicz, H. [Tel Aviv Univ. (Israel). School of Physics; Max Planck Institute for Physics, Munich (Germany); Abt, I. [Max Planck Institute for Physics, Munich (Germany); Adamczyk, L. [AGH-Univ. of Science and Technology, Krakow (Poland). Faculty of Physics and Applied Computer Science; Collaboration: ZEUS Collaboration; and others

    2014-05-15

    The production of beauty and charm quarks in ep interactions has been studied with the ZEUS detector at HERA for exchanged four-momentum squared 5beauty and charm content in events with at least one jet have been extracted using the invariant mass of charged tracks associated with secondary vertices and the decay-length significance of these vertices. Differential cross sections as a function of Q{sup 2}, Bjorken x, jet transverse energy and pseudorapidity were measured and compared with next-to-leading-order QCD calculations. The beauty and charm contributions to the proton structure functions were extracted from the double-differential cross section as a function of x and Q{sup 2}. The running beauty-quark mass, m{sub b} at the scale m{sub b}, was determined from a QCD fit at next-to-leading order to HERA data for the first time and found to be m{sub b}(m{sub b})=4.07±0.14(fit){sup +0.01}{sub -0.07} (mod.){sup +0.05}{sub -0.00}(param.){sup +0.08}{sub -0.05}(theo) GeV.

  7. DNA: Structure and function

    DEFF Research Database (Denmark)

    Sinden, Richard R.; E. Pearson, Christopher; N. Potaman, Vladimir

    1998-01-01

    This chapter discusses the structure and function of DNA. DNA occupies a critical role in cells, because it is the source of all intrinsic genetic information. Chemically, DNA is a very stable molecule, a characteristic important for a macromolecule that may have to persist in an intact form...... for a long period of time before its information is accessed by the cell. Although DNA plays a critical role as an informational storage molecule, it is by no means as unexciting as a computer tape or disk drive. The structure of the DNA described by Watson and Crick in 1953 is a right handed helix of two...

  8. Charm and Beauty Production from Semileptonic Decays at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Juengst, Markus [Universitaet Bonn (Germany)

    2010-07-01

    Measurement of the photoproduction of b-quarks at threshold at HERA The cross section of bb-bar photoproduction in ep collisions is measured with the H1 detector at HERA. Events containing b-quarks are identified through detection of two low momentum electrons in the final state. Semileptonic decays bb-bar {yields} ee X are exploited in the kinematic range of the photon virtuality Q{sup 2} < 1 GeV{sup 2}, the inelasticity 0.2 < y < 0.8 and the pseudorapidity of the b-quarks |{eta}(b), {eta}(b-bar)| < 2. The differential b-quark production cross section is measured as a function of the transverse b-quark momentum and extends the previously experimentally accessible phase space towards the b-quark production threshold. The results are compared to other b-quark cross section measurements, as well as to QCD predictions. Measurement of charm and beauty production in deep inelastic ep scattering from decays into muons at HERA The production of charm and beauty quarks in ep interactions has been measured with the ZEUS detector at HERA for squared four-momentum exchange Q{sup 2}>20 GeV{sup 2}, using an integrated luminosity of 126 pb{sup -1}. Charm and beauty quarks were identified through their decays into muons. Differential cross sections were measured for muon transverse momenta p{sub T}{sup {mu}>}1.5 GeV and pseudo-rapidities -1.6<{eta}{sup {mu}<}2.3, as a function of p{sub T}{sup {mu}}, {eta}{sup {mu}}, Q{sup 2} and Bjorken x. The charm and beauty contributions to the proton structure function F{sub 2} were also extracted. The results agree with previous measurements based on independent techniques and are well described by QCD predictions. Measurement of beauty production in DIS and F2b b-bar extraction at ZEUS Beauty production in deep inelastic scattering with events in which a muon and a jet are observed in the final state has been measured with the ZEUS detector at HERA using an integrated luminosity of 114 pb{sup -1}. The fraction of events with beauty quarks

  9. Golden Ratio: A Measure of Physical Beauty

    Indian Academy of Sciences (India)

    2017-01-01

    Our attraction to another body increases if the body is symmetricaland in proportion. If a face or a structure is in proportion,we are more likely to notice it and find it beautiful.The universal ratio of beauty is the ‘Golden Ratio’, found inmany structures. This ratio comes from Fibonacci numbers.In this article, we explore this concept along with its applications.

  10. Beauty and Cuteness in Peripheral Vision

    Directory of Open Access Journals (Sweden)

    Kana eKuraguchi

    2015-05-01

    Full Text Available Guo, Liu, & Roebuck (2011 showed that attractiveness was detectable in peripheral vision. Since there are different types of attractiveness (Rhodes, 2006, we investigated how beauty and cuteness are detected in peripheral vision with a brief presentation. Participants (n = 45 observed two Japanese female faces for 100 ms, then were asked to respond which face was more beautiful (or cuter. The results indicated that both beauty and cuteness were detectable in peripheral vision, but not in the same manner. Discrimination rates for judging beauty were invariant in peripheral and central vision, while discrimination rates for judging cuteness declined in peripheral vision as compared with central vision. This was not explained by lower resolution in peripheral vision. In addition, for male participants, it was more difficult to judge cuteness than beauty in peripheral vision, thus suggesting that gender differences can have a certain effect when judging cuteness. Therefore, central vision might be suitable for judging cuteness while judging beauty might not be affected by either central or peripheral vision. This might be related with the functional difference between beauty and cuteness.

  11. Beauty and cuteness in peripheral vision

    Science.gov (United States)

    Kuraguchi, Kana; Ashida, Hiroshi

    2015-01-01

    Guo et al. (2011) showed that attractiveness was detectable in peripheral vision. Since there are different types of attractiveness (Rhodes, 2006), we investigated how beauty and cuteness are detected in peripheral vision with a brief presentation. Participants (n = 45) observed two Japanese female faces for 100 ms, then were asked to respond which face was more beautiful (or cuter). The results indicated that both beauty and cuteness were detectable in peripheral vision, but not in the same manner. Discrimination rates for judging beauty were invariant in peripheral and central vision, while discrimination rates for judging cuteness declined in peripheral vision as compared with central vision. This was not explained by lower resolution in peripheral vision. In addition, for male participants, it was more difficult to judge cuteness than beauty in peripheral vision, thus suggesting that gender differences can have a certain effect when judging cuteness. Therefore, central vision might be suitable for judging cuteness while judging beauty might not be affected by either central or peripheral vision. This might be related with the functional difference between beauty and cuteness. PMID:25999883

  12. Beauty and cuteness in peripheral vision.

    Science.gov (United States)

    Kuraguchi, Kana; Ashida, Hiroshi

    2015-01-01

    Guo et al. (2011) showed that attractiveness was detectable in peripheral vision. Since there are different types of attractiveness (Rhodes, 2006), we investigated how beauty and cuteness are detected in peripheral vision with a brief presentation. Participants (n = 45) observed two Japanese female faces for 100 ms, then were asked to respond which face was more beautiful (or cuter). The results indicated that both beauty and cuteness were detectable in peripheral vision, but not in the same manner. Discrimination rates for judging beauty were invariant in peripheral and central vision, while discrimination rates for judging cuteness declined in peripheral vision as compared with central vision. This was not explained by lower resolution in peripheral vision. In addition, for male participants, it was more difficult to judge cuteness than beauty in peripheral vision, thus suggesting that gender differences can have a certain effect when judging cuteness. Therefore, central vision might be suitable for judging cuteness while judging beauty might not be affected by either central or peripheral vision. This might be related with the functional difference between beauty and cuteness.

  13. Beauty in the Breakdown

    Science.gov (United States)

    Brisco, Nicole

    2008-01-01

    Most human beings look at erosion as the destruction of a surface, but artists can see that erosion often creates indefinable beauty. Where do you see beauty in the breakdown? In this article, the author presents an innovative lesson that would allow students to observe both human and physical nature. In this activity students will create a work…

  14. Musings about Beauty

    Science.gov (United States)

    Kintsch, Walter

    2012-01-01

    In this essay, I explore how cognitive science could illuminate the concept of beauty. Two results from the extensive literature on aesthetics guide my discussion. As the term "beauty" is overextended in general usage, I choose as my starting point the notion of "perfect form." Aesthetic theorists are in reasonable agreement about the criteria for…

  15. Charm, Beauty and Top at HERA

    CERN Document Server

    Behnke, O; Lisovyi, M

    2015-01-01

    Results on open charm and beauty production and on the search for top production in high-energy electron-proton collisions at HERA are reviewed. This includes a discussion of relevant theoretical aspects, a summary of the available measurements and measurement techniques, and their impact on improved understanding of QCD and its parameters, such as parton density functions and charm- and beauty-quark masses. The impact of these results on measurements at the LHC and elsewhere is also addressed.

  16. Charm, Beauty and Top at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Behnke, O.; Geiser, A.; Lisovyi, M.

    2015-06-15

    Results on open charm and beauty production and on the search for top production in high-energy electron-proton collisions at HERA are reviewed. This includes a discussion of relevant theoretical aspects, a summary of the available measurements and measurement techniques, and their impact on improved understanding of QCD and its parameters, such as parton density functions and charm- and beauty-quark masses. The impact of these results on measurements at the LHC and elsewhere is also addressed.

  17. Measruement of beauty production in DIS and F{sub 2}{sup b} {sup anti} {sup b} extraction at ZEUS

    Energy Technology Data Exchange (ETDEWEB)

    Abramowicz, H. [Tel Aviv Univ. (Israel). School of Physics; Univ. College London (United Kingdom); Max Planck Institute, Munich (Germany); Abt, I. [Max-Planck-Institut fuer Physik, Muenchen (Germany); Adamczyk, L. [AGH-Univ. of Science and Technology, Cracow (PL). Faculty of Physics and Applied Computer Science] (and others)

    2010-04-15

    Beauty production in deep inelastic scattering with events in which a muon and a jet are observed in the final state has been measured with the ZEUS detector at HERA using an integrated luminosity of 114 pb{sup -1}. The fraction of events with beauty quarks in the data was determined using the distribution of the transverse momentum of the muon relative to the jet. The cross section for beauty production was measured in the kinematic range of photon virtuality, Q{sup 2}>2 GeV{sup 2}, and inelasticity, 0.05beauty contribution to the structure function F{sub 2} was extracted and is compared to theoretical predictions. (orig.)

  18. Beauty in chemistry

    Directory of Open Access Journals (Sweden)

    Peter Atkins

    2006-03-01

    Full Text Available Though hard going for the general reader and highly personal in its selectivity, Elegant Solutions: Ten Beautiful Experiments in Chemistry provides reflections of a thoughtful author that will delight chemists

  19. Black Hair is Beautiful

    Institute of Scientific and Technical Information of China (English)

    1994-01-01

    On June 9, the 1994 ⅩⅢ Asian Make-up and Hairstyling Competition was held in Beijing. More than 200 contestants from 12 countries and regions across Asia participated. The competition is now considered the largest and most prestigious exchange activity in Asian beauty and hair circles. Black Hair is Beautiful" was the theme of this competition, which stressed Asian physical characteristics and aesthetics.

  20. What Is Beauty?

    Institute of Scientific and Technical Information of China (English)

    胡应余

    2007-01-01

    <正> It seems that beauty and women are twins. You are joking? No, I am not. Observe for yourself. Ads on fashion flood TV screens, radio programs, magazines, newspapers, and the streets. Whether they have realized or not, women are besieged by a sea of fashions. They are taught to think that without beautiful clothes they will grow old and lose their charm. So who dares to neglect dressing up at the cost of their appearance and youth?

  1. Effect of new adjuvant chemotherapy combined with reserving nipple and areola breast modified radical mastectomy on breast retention beauty effect and immune function

    Institute of Scientific and Technical Information of China (English)

    Yan-Lin Xiao

    2015-01-01

    Objective:To study the effects of new adjuvant chemotherapy combined with reserving nipple and areola breast modified radical mastectomy on breast retention beauty effect and immune function.Methods:110 cases patients with breast cancer were enrolled and randomly divided into observation group and control group. Observation group received reserving nipple and areola breast modified radical mastectomy, control group received conventional modified radical mastectomy. Then cosmetic effect, quality of life and negative emotion and immune function were compared.Results:(1) Cosmetic effects: Cosmetic effect of the observation group was significantly better than that of the control group (92.73%vs. 58.18%). (2) Negative emotions: AMA, HAMD, SAS, SDS scores of the observation group were significantly lower than that of the control group; (3) Immune function: CD3+ T cells, CD4+ T cells of the observation group were significantly higher than those of control group; CD8+ T cells were significantly lower than those of control group. (4) Life quality and negative emotions: life quality score and HAMA score, HAMD score, SAS score, SDS score of the observation group were lower than those of control group.Conclusion: Reserving nipple and areola breast modified radical mastectomy helps to improve cosmetic effect, alleviate negative mood, enhance immune function, and improve patients’ life quality.

  2. Is moral beauty different from facial beauty? Evidence from an fMRI study

    OpenAIRE

    Wang, Tingting; Mo, Lei; Mo, Ce; Tan, Li Hai; Cant, Jonathan S.; Zhong, Luojin; Cupchik, Gerald

    2014-01-01

    Is moral beauty different from facial beauty? Two functional magnetic resonance imaging experiments were performed to answer this question. Experiment 1 investigated the network of moral aesthetic judgments and facial aesthetic judgments. Participants performed aesthetic judgments and gender judgments on both faces and scenes containing moral acts. The conjunction analysis of the contrasts ‘facial aesthetic judgment > facial gender judgment’ and ‘scene moral aesthetic judgment > scene gender ...

  3. Beauty: A Concept with Practical Implications for Teacher Researchers

    Science.gov (United States)

    Winston, Joe

    2011-01-01

    Hillman's (2001) simple affirmation that "an idea of beauty is useful, functional, practical" is one this article attempts to pursue with teacher researchers in mind, based on the belief that to move from the "re"pression of beauty to its "ex"pression--or, at the very least, to its articulation--will enlighten rather than distract individuals. The…

  4. Why Landscape Beauty Matters

    Directory of Open Access Journals (Sweden)

    Angelika Krebs

    2014-11-01

    Full Text Available This philosophical paper explores the aesthetic argument for landscape conservation. The main claim is that the experience of beautiful landscapes is an essential part of the good human life. Beautiful landscapes make us feel at home in the world. Their great and irreplaceable value lies therein. To establish this claim, the concepts of landscape and “Stimmung” are clarified. It is shown how “Stimmung” (in the sense of mood is infused into landscape (as atmosphere and how we respond to it aesthetically. We respond by resonating or feeling at home. The paper ends by indicating how art can help us to better appreciate landscape beauty. This is done by way of an example from contemporary nature poetry, Michael Donhauser’s Variationen in Prosa, which begins with “Und was da war, es nahm uns an” (“And what was there accepted us”.

  5. Introduction to Beautiful Soup

    Directory of Open Access Journals (Sweden)

    Jeri Wieringa

    2012-12-01

    Full Text Available Beautiful Soup is a Python library for getting data out of HTML, XML, and other markup languages. Say you’ve found some webpages that display data relevant to your research, such as date or address information, but that do not provide any way of downloading the data directly. Beautiful Soup helps you pull particular content from a webpage, remove the HTML markup, and save the information. It is a tool for web scraping that helps you clean up and parse the documents you have pulled down from the web.

  6. Who Engages with Moral Beauty?

    Science.gov (United States)

    Diessner, Rhett; Iyer, Ravi; Smith, Meghan M.; Haidt, Jonathan

    2013-01-01

    Aristotle considered moral beauty to be the "telos" of the human virtues. Displays of moral beauty have been shown to elicit the moral emotion of elevation and cause a desire to become a better person and to engage in prosocial behavior. Study 1 ("N" = 5380) shows engagement with moral beauty is related to several psychological…

  7. Structure functions at large x

    CERN Document Server

    Zhang, Z

    2002-01-01

    Structure function data together with other measurements from fixed-target deep inelastic scattering and hadron-hadron collider experiments which contribute to our knowledge of the parton density functions are reviewed. The inclusive cross-section measurements of neutral and charged current interactions at HERA are presented and their impact on the parton density functions is discussed. Future prospects for an improved knowledge of the parton density functions at large x are briefly mentioned.

  8. Brain correlates of aesthetic judgment of beauty.

    Science.gov (United States)

    Jacobsen, Thomas; Schubotz, Ricarda I; Höfel, Lea; Cramon, D Yves V

    2006-01-01

    Functional MRI was used to investigate the neural correlates of aesthetic judgments of beauty of geometrical shapes. Participants performed evaluative aesthetic judgments (beautiful or not?) and descriptive symmetry judgments (symmetric or not?) on the same stimulus material. Symmetry was employed because aesthetic judgments are known to be often guided by criteria of symmetry. Novel, abstract graphic patterns were presented to minimize influences of attitudes or memory-related processes and to test effects of stimulus symmetry and complexity. Behavioral results confirmed the influence of stimulus symmetry and complexity on aesthetic judgments. Direct contrasts showed specific activations for aesthetic judgments in the frontomedian cortex (BA 9/10), bilateral prefrontal BA 45/47, and posterior cingulate, left temporal pole, and the temporoparietal junction. In contrast, symmetry judgments elicited specific activations in parietal and premotor areas subserving spatial processing. Interestingly, beautiful judgments enhanced BOLD signals not only in the frontomedian cortex, but also in the left intraparietal sulcus of the symmetry network. Moreover, stimulus complexity caused differential effects for each of the two judgment types. Findings indicate aesthetic judgments of beauty to rely on a network partially overlapping with that underlying evaluative judgments on social and moral cues and substantiate the significance of symmetry and complexity for our judgment of beauty.

  9. "Soccer": The Beautiful Game

    Science.gov (United States)

    Spires, Todd

    2008-01-01

    Soccer, or football as it is called in the rest of the world, is the most popular and fastest-growing global sport, with an estimated 240 million people regularly playing what Brazilian star Pele called "the beautiful game." Millions, worldwide, watch it on television. In 2006, the average viewership for each match of the month-long World Cup was…

  10. The Trend of Beauty

    Institute of Scientific and Technical Information of China (English)

    LINDA; LEE

    1995-01-01

    EVER since ancient times Shanghai people have pursued beauty. The Shanghai History Museum, mounted an exhibition entitled "Spectacular Garments, Cultural Relics and Documents of Modern Shanghai" which certainly proved this point. This exhibit showed that throughout Shanghai’s long history, dress and personal adomment have been important to the residents. During the twentieth

  11. My Beautiful Friend

    Institute of Scientific and Technical Information of China (English)

    雷全

    2004-01-01

    I have many toys in my room.Al-though they can’t speak,I treat them asmy friends.I like playing with them.Among them,my favorite is the beautiful girl-Barbiedoll.Her name is Kelly,same as my English name.She cameto my family a year ago as my birthday gift.

  12. A Sleeping Beauty DNA transposon-based genetic sensor for functional screening of vitamin D3 analogues

    DEFF Research Database (Denmark)

    Staunstrup, Nicklas H; Sharma, Nynne; Bak, Rasmus O

    2011-01-01

    Analogues of vitamin D3 are extensively used in the treatment of various illnesses, such as osteoporosis, inflammatory skin diseases, and cancer. Functional testing of new vitamin D3 analogues and formulations for improved systemic and topical administration is supported by sensitive screening me...

  13. Structural Chemistry of Functional Materials

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    @@ This innovative research group on structural chemistry of functional materials was approved by NSFC in 2005.Headed by Prof.HONG Maochun, the team consists of several young research scientists from the CAS Fujian Institute of Research on the Structures of Matter, including Profs CAO Rong, LU Canzhong, GUO Guocong, CHEN Zhongning, MAO Jianggao Mao and CHEN Ling.

  14. A Sleeping Beauty DNA transposon-based genetic sensor for functional screening of vitamin D3 analogues

    DEFF Research Database (Denmark)

    Staunstrup, Nicklas Heine; Sharma, Nynne; Bak, Rasmus Otkjær;

    2011-01-01

    Analogues of vitamin D3 are extensively used in the treatment of various illnesses, such as osteoporosis, inflammatory skin diseases, and cancer. Functional testing of new vitamin D3 analogues and formulations for improved systemic and topical administration is supported by sensitive screening me...... analogues. The tri-cistronic genetic sensor encodes a drug-sensoring protein, a reporter protein expressed from an activated sensor-responsive promoter, and a resistance marker....

  15. The experience of mathematical beauty and its neural correlates.

    Science.gov (United States)

    Zeki, Semir; Romaya, John Paul; Benincasa, Dionigi M T; Atiyah, Michael F

    2014-01-01

    Many have written of the experience of mathematical beauty as being comparable to that derived from the greatest art. This makes it interesting to learn whether the experience of beauty derived from such a highly intellectual and abstract source as mathematics correlates with activity in the same part of the emotional brain as that derived from more sensory, perceptually based, sources. To determine this, we used functional magnetic resonance imaging (fMRI) to image the activity in the brains of 15 mathematicians when they viewed mathematical formulae which they had individually rated as beautiful, indifferent or ugly. Results showed that the experience of mathematical beauty correlates parametrically with activity in the same part of the emotional brain, namely field A1 of the medial orbito-frontal cortex (mOFC), as the experience of beauty derived from other sources.

  16. The experience of mathematical beauty and its neural correlates

    Directory of Open Access Journals (Sweden)

    Semir eZeki

    2014-02-01

    Full Text Available Many have written of the experience of mathematical beauty as being comparable to that derived from the greatest art. This makes it interesting to learn whether the experience of beauty derived from such a highly intellectual and abstract source such as mathematics correlates with activity in the same part of the emotional brain as that derived from more sensory, perceptually based, sources. To determine this, we used functional magnetic resonance imaging (fMRI to image the activity in the brains of 15 mathematicians when they viewed mathematical formulae which they had individually rated as beautiful, indifferent or ugly. Results showed that the experience of mathematical beauty correlates parametrically with activity in the same part of the emotional brain, namely field A1 of the medial orbito-frontal cortex (mOFC, as the experience of beauty derived from other sources.

  17. Measurement of charm and beauty production in deep inelastic ep scattering from decays into muons at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Chekanov, S.; Derrick, M.; Magill, S [Argonne National Lab., Argonne, IL (US)] (and others)

    2009-04-15

    The production of charm and beauty quarks in ep interactions has been measured with the ZEUS detector at HERA for squared four-momentum exchange Q{sup 2} > 20GeV{sup 2}, using an integrated luminosity of 126 pb{sup -1}. Charm and beauty quarks were identified through their decays into muons. Differential cross sections were measured for muon transverse momenta p{sub T}{sup {mu}}>1.5 GeV and pseudorapidities -1.6<{eta}{sup {mu}}<2.3, as a function of p{sub T}{sup {mu}}, {eta}{sup {mu}}, Q{sup 2} and Bjorken x. The charm and beauty contributions to the proton structure function F{sub 2} were also extracted. The results agree with previous measurements based on independent techniques and are well described by QCD predictions. (orig.)

  18. Measurement of charm and beauty production in deep inelastic ep scattering from decays into muons at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Chekanov, S.; Derrick, M.; Magill, S.; Musgrave, B.; Nicholass, D.; Repond, J.; Yoshida, R. [Argonne National Laboratory, Argonne, IL (United States); Mattingly, M.C.K. [Andrews University, Berrien Springs, MI (United States); Antonioli, P.; Bari, G.; Bellagamba, L.; Boscherini, D.; Bruni, A.; Bruni, G.; Cindolo, F.; Corradi, M.; Iacobucci, G.; Margotti, A.; Nania, R.; Polini, A. [INFN Bologna, Bologna (Italy); Antonelli, S.; Basile, M.; Bindi, M.; Cifarelli, L.; Contin, A.; De Pasquale, S.; Sartorelli, G.; Zichichi, A. [Bologna University (Italy); INFN Bologna, Bologna (Italy); Bartsch, D.; Brock, I.; Hartmann, H.; Hilger, E.; Jakob, H.P.; Juengst, M.; Nuncio-Quiroz, A.E.; Paul, E.; Samson, U.; Schoenberg, V.; Shehzadi, R.; Wlasenko, M. [Physikalisches Institut der Universitaet Bonn, Bonn (Germany); Brook, N.H.; Heath, G.P.; Morris, J.D. [University of Bristol, H.H. Wills Physics Laboratory, Bristol (United Kingdom); Kaur, M.; Kaur, P.; Singh, I. [Panjab University, Department of Physics, Chandigarh (India); Capua, M.; Fazio, S.; Mastroberardino, A.; Schioppa, M.; Susinno, G.; Tassi, E. [Calabria University, Physics Department (Italy); INFN, Cosenza (Italy); Kim, J.Y. [Chonnam National University, Kwangju (Korea); Ibrahim, Z.A.; Mohamad Idris, F.; Kamaluddin, B.; Wan Abdullah, W.A.T. [Universiti Malaya, Jabatan Fizik, Kuala Lumpur (Malaysia); Ning, Y.; Ren, Z.; Sciulli, F. [Columbia Univ., Nevis Laboratories, Irvington on Hudson, NY (United States); Chwastowski, J.; Eskreys, A.; Figiel, J.; Galas, A.; Olkiewicz, K.; Pawlik, B.; Stopa, P.; Zawiejski, L. [Polish Academy of Sciences, Henryk Niewodniczanski Inst. of Nuclear Physics, Cracow (Poland); Adamczyk, L.; Bold, T.; Grabowska-Bold, I.; Kisielewska, D.; Lukasik, J.; Przybycien, M.; Suszycki, L. [AGH-Univ. of Science and Technology, Faculty of Physics and Applied Computer Science, Cracow (Poland); Kotanski, A.; Slominski, W. [Jagellonian Univ., Dept. of Physics, Cracow (Poland)] [and others

    2010-01-15

    The production of charm and beauty quarks in ep interactions has been measured with the ZEUS detector at HERA for squared four-momentum exchange Q{sup 2}>20 GeV{sup 2}, using an integrated luminosity of 126 pb{sup -1}. Charm and beauty quarks were identified through their decays into muons. Differential cross sections were measured for muon transverse momenta p{sub T}{sup {mu}}>1.5 GeV and pseudorapidities -1.6<{eta} {sup {mu}} <2.3, as a function of p{sub T}{sup {mu}}, {eta}{sup {mu}}, Q{sup 2} and Bjorken x. The charm and beauty contributions to the proton structure function F{sub 2} were also extracted. The results agree with previous measurements based on independent techniques and are well described by QCD predictions. (orig.)

  19. Small is beautiful

    Energy Technology Data Exchange (ETDEWEB)

    Schumacher, E.F.

    1973-01-01

    The author feels that ''an almost universal idolatry of gigantism'' has caused the urgent crisis of today's society. The book expresses his philosophy of the beauty of thinking in less grandiose terms. He offers some smaller-scale yet highly feasible solutions to many of the problems created by bigness--the environmental crisis, the energy shortage, the dehumanization of industrial workers, the flight from rural areas, and the decay of cities. (MCW)

  20. Politics of Beauty

    Directory of Open Access Journals (Sweden)

    Ken-ichi Sasaki

    2011-01-01

    Full Text Available I look back at the history of modern aesthetics to grasp its current situation and to propose its possibilities for the future. The early modern period, during which aesthetics came into being, was a great historical turning point for civilization. Our contemporary period shares this character, and it is worthwhile for us to consult its history in order to reflect on our civilization. Aesthetics began with Baumgarten’s proposal, which consisted in a triple subject: sensibility, beauty, and art. His idea was accepted because it responded to the fundamental problems of the period. Sensibility was the only form of cognition of value in a re-formed world (Pascal. Art existed in three forms: official, social, and solitary and reflective. The first (San Pietro and Versailles promoted art to the rank of high culture, and it was the third form that presented aesthetics as the philosophy of art. But in the early modern period, aesthetics was first of all the philosophy of beauty because beauty guaranteed the rationality and order of the new world (Shaftesbury, Malebranche. Modern aesthetics, however, was a philosophy of art under the general trends of anthropocentrism. The pursuit of originality led to Duchamp’s Fountain, after which there remains nothing new for art to do. We now confront urgent problems, such as global warming and conflict between different civilizations, etc., which suggest the need for changing the way of managing the world. Under this situation, I think aesthetics holds new and real possibilities for the philosophy of beauty.

  1. Two beautiful new particles

    CERN Multimedia

    Antonella Del Rosso

    2012-01-01

    In beautiful agreement with the Standard Model, two new excited states (see below) of the Λb beauty particle have just been observed by the LHCb Collaboration. Similarly to protons and neutrons, Λb is composed of three quarks. In the Λb’s case, these are up, down and… beauty.   Although discovering new particles is increasingly looking like a routine exercise for the LHC experiments (see previous features), it is far from being an obvious performance, particularly when the mass of the particles is high. Created in the high-energy proton-proton collisions produced by the LHC, these new excited states of the Λb particle have been found to have a mass of, respectively, 5912 MeV/c2 and 5920 MeV/c2. In other words, they are over five times heavier than the proton or the neutron. Physicists only declare a discovery when data significantly show the relevant signal. In order to do that, they often have to analyse large samples of data. To ...

  2. Structure functions and parton distributions

    Energy Technology Data Exchange (ETDEWEB)

    Martin, A.D.; Stirling, W.J. [Univ. of Durham (United Kingdom); Roberts, R.G. [Rutherford Appleton Lab., Chilton, Didcot (United Kingdom)

    1995-07-01

    The MRS parton distribution analysis is described. The latest sets are shown to give an excellent description of a wide range of deep-inelastic and other hard scattering data. Two important theoretical issues-the behavior of the distributions at small x and the flavor structure of the quark sea-are discussed in detail. A comparison with the new structure function data from HERA is made, and the outlook for the future is discussed.

  3. Proton structure functions at HERA

    Science.gov (United States)

    Stella, Bruno

    2001-10-01

    The electron-proton collider HERA, like an electron-mycroscope, explores the structure of the proton down to 10-16 cm and up to the situation of very high parton densities. The proton energy was upgraded from 820 to 920 GeV in the Fall of '98 and the luminosity has also substantially improved, with another factor of 3 upgrade expected to follow this year. Inclusive proton structure functions have been studied with incident e+ and e- of 27 GeV in the neutral (NC) and charged (CC) current interactions as functions of the squared four-momentum transfer, Q2, and of the fractional proton momentum carried by partons, x. The structure function F2, as well as the γ-Z0 interference term xF3, have been measured in a range of Q2 and 1/x that extends by orders of magnitude that reached by fixed target experiments. The DGLAP evolution equations [1] allow for a perturbative NLO QCD fit of the measured non-perturbative structure functions in the available kinematic range: αS and the gluon density at low x are fitted at the same time with good precision. The longitudinal structure function, FL, can be determined within the DGLAP formalism. With CC, the electroweak unification has been tested; at high x, a first flavor decomposition of the light quarks is achieved. The contribution to F2 of the charm quark has been measured and results to be relevant. Bounds on the radius of quarks and on compositeness are derived from the data at the highest Q2, 100

  4. Fibonacci, quasicrystals and the beauty of flowers.

    Science.gov (United States)

    Gardiner, John

    2012-12-01

    The appearance of Fibonacci sequences and the golden ratio in plant structures is one of the great outstanding puzzles of biology. Here I suggest that quasicrystals, which naturally pack in the golden ratio, may be ubiquitous in biological systems and introduce the golden ratio into plant phyllotaxy. The appearance of golden ratio-based structures as beautiful indicates that the golden ratio may play a role in the development of consciousness and lead to the aesthetic natural selection of flowering plants.

  5. Fibonacci, quasicrystals and the beauty of flowers

    Science.gov (United States)

    Gardiner, John

    2012-01-01

    The appearance of Fibonacci sequences and the golden ratio in plant structures is one of the great outstanding puzzles of biology. Here I suggest that quasicrystals, which naturally pack in the golden ratio, may be ubiquitous in biological systems and introduce the golden ratio into plant phyllotaxy. The appearance of golden ratio-based structures as beautiful indicates that the golden ratio may play a role in the development of consciousness and lead to the aesthetic natural selection of flowering plants. PMID:23072998

  6. Theoretical Framework and Model Design for Beautiful Countryside Construction in China

    Directory of Open Access Journals (Sweden)

    ZHENG Xiang-qun

    2015-04-01

    Full Text Available In the context of China today, the process of beautiful countryside construction mainly imitates the patterns of‘urbanization’construction. However, this approach leads to the loss of countryside characteristics and the separation of agricultural culture. Therefore, it's urgent to carry out research of the theoretical framework and model design for beautiful countryside construction. In this paper, based on the analysis of the beautiful countryside construction connotation, the basic theory of beautiful countryside construction was summarized in three aspects: rural complex ecosystem model, multi-functionality of rural model and sustainable development evaluation model. The basic idea of the beautiful countryside construction mode was studied. The design method of beautiful countryside construction mode was proposed in three levels: planning, scheming and evaluating. The research results might offer scientific reference for improving the scientific and operational nature of beautiful countryside construction.

  7. [Protein phosphatases: structure and function].

    Science.gov (United States)

    Bulanova, E G; Budagian, V M

    1994-01-01

    The process of protein and enzyme systems phosphorylation is necessary for cell growth, differentiation and preparation for division and mitosis. The conformation changes of protein as a result of phosphorylation lead to increased enzyme activity and enhanced affinity to substrates. A large group of enzymes--protein kinases--is responsible for phosphorylation process in cell, which are divided into tyrosine- and serine-threonine-kinases depending on their ability to phosphorylate appropriate amino acid residues. In this review has been considered the functional importance and structure of protein phosphatases--enzymes, which are functional antagonists of protein kinases.

  8. THE BEAUTY OF THE WORLD IN PLATO’S TIMAEUS

    Directory of Open Access Journals (Sweden)

    O’Meara, Dominic

    2014-01-01

    Full Text Available In the Timaeus Plato describes the world as the ‘most beautiful’ (kallistos, 29a5 of generated things. Perhaps indeed this is the first systematic description of the beauty of the world. It is, at any rate, one of the most influential statements of the theme. The Stoics were deeply convinced by it and later, in the third century A.D., at a time when contempt and hate for the world were propagated by Gnostic movements, Plotinus, interpreting the Timaeus, would write magnificent passages on the beauty and value of the world. But what does Plato mean by the ‘beauty’ of the world? What makes the world beautiful? In this paper these questions are approached first (1 by a brief discussion of the distinction which Plato appears to make in the Timaeus between beauty and the good. In one passage (Tim. 87c ‘measure’ seems to relate to this distinction. It is suitable then (2 to look at a section of another late work of Plato, the Philebus, where the themes of beauty, goodness and measure may be compared in more detail. The theme of measure then takes us back (3 to the Timaeus, in order to examine the role played by measure, in particular mathematical measure, in constituting the beauty of the world. I discuss in detail the way in which mathematical structures make for the beauty of soul and body in the living whole that is the world.

  9. Literary aesthetics: beauty, the brain, and Mrs. Dalloway.

    Science.gov (United States)

    Hogan, Patrick Colm

    2013-01-01

    Empirical research indicates that beauty is in part a matter of prototype approximation. Some research suggests that unanticipated pattern recognition is important as well. This essay begins by briefly outlining an account of beauty based on these factors. It goes on to consider complications. Minor complications include the partial incompatibility of these accounts and the importance of differentiating judgments of beauty from aesthetic response. More serious issues include the relative neglect of literature in neurologically-based discussions of beauty, which tend to focus on music or visual art. There is also a relative neglect of emotion, beyond the reward system. Finally, there is the almost complete absence of the sublime. After considering these problems broadly, the essay turns to Virginia Woolf's Mrs. Dalloway, examining its treatment of beauty and sublimity. The aim of this section is not merely to illuminate Woolf's novel by reference to neuroscientific research. It is equally, perhaps more fully, to expand our neuroscientifically grounded account of aesthetic response by drawing on Woolf's novel. In Mrs. Dalloway, there are gestures toward prototypes and patterns in beauty. But the key features are clearly emotional. Specifically, the emotions at issue in feelings of beauty and sublimity appear to be primarily attachment, on the one hand, and a profound sense of isolation, on the other. Woolf's novel also points us toward other features of aesthetic experience, crucially including the emotion-sharing that is a key function of the production and circulation of art.

  10. Structure and Function of Glucansucrases

    Science.gov (United States)

    Dijkstra, B. W.; Vujičić-Žagar, A.

    2008-03-01

    Glucansucrases are relatively large (~160 kDa) extracellular enzymes produced by lactic acid bacteria. Using sucrose as a substrate they synthesize high molecular mass glucose polymers, called α-glucans, which allow the bacteria to adhere to surfaces and create a biofilm. The glucan polymers are of importance for the food and dairy industry as thickening and jellying agents. An overview is given of the current insights into the structure and functioning of these and related enzymes.

  11. Escaping Beauty through moral narratives

    DEFF Research Database (Denmark)

    Sloth, Erik

    2010-01-01

    This study investigate through ethnographic studies the shared cultural meanings expressed about human beauty. How is sense making about the notion of beauty constructed, verballized and negotiated in a group of young females between 24 and 26 years old. Furthermore the study discuss and elaborat...

  12. Sublime Views and Beautiful Explanations

    DEFF Research Database (Denmark)

    Barry, Daved; Meisiek, Stefan; Hatch, Mary Jo

    To create a generative theory that provides beautiful explanations and sublime views requires both a crafts and an art approach to scientific theorizing. The search for generativity leads scholars to perform various theorizing moves between the confines of simple, yet eloquent beauty...

  13. The experience of mathematical beauty and its neural correlates.

    OpenAIRE

    Semir eZeki; John Paul Romaya; Benincasa, Dionigi M. T.; Atiyah, Michael F.

    2014-01-01

    Many have written of the experience of mathematical beauty as being comparable to that derived from the greatest art. This makes it interesting to learn whether the experience of beauty derived from such a highly intellectual and abstract source such as mathematics correlates with activity in the same part of the emotional brain as that derived from more sensory, perceptually based, sources. To determine this, we used functional magnetic resonance imaging (fMRI) to image the activity in the b...

  14. Mitochondria: isolation, structure and function.

    Science.gov (United States)

    Picard, Martin; Taivassalo, Tanja; Gouspillou, Gilles; Hepple, Russell T

    2011-09-15

    Mitochondria are complex organelles constantly undergoing processes of fusion and fission, processes that not only modulate their morphology, but also their function. Yet the assessment of mitochondrial function in skeletal muscle often involves mechanical isolation of the mitochondria, a process which disrupts their normally heterogeneous branching structure and yields relatively homogeneous spherical organelles. Alternatively, methods have been used where the sarcolemma is permeabilized and mitochondrial morphology is preserved, but both methods face the downside that they remove potential influences of the intracellular milieu on mitochondrial function. Importantly, recent evidence shows that the fragmented mitochondrial morphology resulting from routine mitochondrial isolation procedures used with skeletal muscle alters key indices of function in a manner qualitatively similar to mitochondria undergoing fission in vivo. Although these results warrant caution when interpreting data obtained with mitochondria isolated from skeletal muscle, they also suggest that isolated mitochondrial preparations might present a useful way of interrogating the stress resistance of mitochondria. More importantly, these new findings underscore the empirical value of studying mitochondrial function in minimally disruptive experimental preparations. In this review, we briefly discuss several considerations and hypotheses emerging from this work.

  15. The structure and function of fungal cells

    Science.gov (United States)

    Nozawa, Y.

    1984-01-01

    The structure and function of fungal cell walls were studied with particular emphasis on dermatophytes. Extraction, isolation, analysis, and observation of the cell wall structure and function were performed. The structure is described microscopically and chemically.

  16. Tissue Factor Structure and Function

    Directory of Open Access Journals (Sweden)

    Saulius Butenas

    2012-01-01

    Full Text Available Tissue factor (TF is an integral membrane protein that is essential to life. It is a component of the factor VIIa-TF complex enzyme and plays a primary role in both normal hemostasis and thrombosis. With a vascular injury, TF becomes exposed to blood and binds plasma factor VIIa, and the resulting complex initiates a series of enzymatic reactions leading to clot formation and vascular sealing. Many cells, both healthy, and tumor cells, produce detectable amounts of TF, especially when they are stimulated by various agents. Despite the relative simplicity and small size of TF, there are numerous contradictory reports about the synthesis and presentation of TF on blood cells and circulation in normal blood either on microparticles or as a soluble protein. Another subject of controversy is related to the structure/function of TF. It has been almost commonly accepted that cell-surface-associated TF has low (if any activity, that is, is “encrypted” and requires specific conditions/reagents to become active, that is, “decrypted.” However there is a lack of agreement related to the mechanism and processes leading to alterations in TF function. In this paper TF structure, presentation, and function, and controversies concerning these features are discussed.

  17. Supramolecular Structure and Function 9

    CERN Document Server

    Pifat-Mrzljak, Greta

    2007-01-01

    The book is based on International Summer Schools on Biophysics held in Croatia which, contrary to other workshops centered mainly on one topic or technique, has very broad scope providing advanced training in areas related to biophysics. This volume is presenting papers in the field of biophysics for studying biological phenomena by using physical methods (NMR, EPR, FTIR, Mass Spectrometry, etc.) and/or concepts (predictions of protein-protein interactions, virtual ligand screening etc.). The interrelationship of supramolecular structures and there functions is enlightened by applications of principals of these physical methods in the biophysical and molecular biology context.

  18. Structure and function of aggrecan

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Aggrecan is the major proteoglycan in the articular cartilage. This molecule is important in the proper functioning of articular cartilage because it provides a hydrated gel structure (via its interaction with hyaluronan and link protein) that endows the cartilage with load-bearing properties. It is also crucial in chondroskeletal morphogenesis during development. Aggrecan is a multimodular molecule expressed by chondrocytes. Its core protein is composed of three globular domains (Gl, G2, and G3) and a large extended region (CS) between G2 and G3 for glycosaminoglycan chain attachment. G1 comprises the amino terminus of the core protein. This domain has the same structural motif as link protein. Functionally, the G1 domain interacts with hyaluronan acid and link protein, forming stable ternary complexes in the extracellular matrix.G2 is homologous to the tandem repeats of G1 and of link protein and is involved in product processing. G3makes up the carboxyl terminus of the core protein. It enhances glycosaminoglycan modification and product secretion. Aggrecan plays an important role in mediating chondrocyte-chondrocyte and chondrocyte-matrix interactions through its ability to bind hyaluronan.

  19. Engagement with beauty: appreciating natural, artistic, and moral beauty.

    Science.gov (United States)

    Diessner, Rhett; Solom, Rebecca C; Frost, Nellie K; Parsons, Lucas; Davidson, John

    2008-05-01

    The Engagement With Beauty Scale (EBS), designed from the aesthetics of I. Kant (1790/1987), G. W. F. Hegel (ca. 1835/1993), and T. Aquinas (ca. 1260/1947) and the psychological work of J. Haidt (J. Haidt & D. Keltner, 2004), measures engagement with natural, artistic, and moral beauty. In Studies 1 and 2, the authors describe scale construction, exploratory factor analysis, confirmatory factor analysis, internal consistency, and temporal stability. In Studies 1 and 2, the authors also establish concurrent validity with the Appreciation of Beauty and Excellence subscale of the Values in Action Inventory of Strengths (C. Peterson & M. E. P. Seligman, 2004), the Gratitude, Resentment, and Appreciation Test (P. C. Watkins, K. Woodward, T. Stone, & R. L. Kolts, 2003), and the Spiritual Transcendence Scale (R. L. Piedmont, 2004). In Study 3, the authors used the EBS Artistic Beauty subscale to differentiate students engaged in the arts from those who were not.

  20. The Classification of Design Beauty from the Perspective of Human’s Cognitive-affective-volitional Structure%从人的知情意结构角度对设计美的分类1

    Institute of Scientific and Technical Information of China (English)

    张黔

    2016-01-01

    According to Immanuel Kant, human’s psychological structure can be divided into three aspects: cognition, affection and volition. Such a tripartite structure can be used as the standard for the classification of design beauty. Patterns of design beauty that focus on cognition (human’s cognitive ability) convey philosophical interest. Objects of this type employ standardized but interesting expressive forms to reveal human’s rational spirit and advanced technology. Patterns of design beauty that emphasize affection (emotional competence) convey humor. Objects of this type use exaggerated and paradoxical relationship combined by the content and the form to relfect the superiority of the main body. Patterns of design beauty that put high value on volition (desire) convey gorgeousness. Objects of this type apply exquisite craft, expensive material and intricate combination way to show the distinctive status of the main body.%按按康德的观点,人的心理结构可分为知、情、意三个方面。这种三分结构可作为设计美的分类的标准。侧重于知——人的认知能力的设计美形态是理趣,是对象以规范合理且不乏趣味的形式体现出人的理性精神与先进技术的设计美形态。侧重于情——情感能力的设计美形态是诙谐,是对象以夸张的、矛盾的内容与形式的组合关系体现出主体的优越感的设计美形态。侧重于意——欲望的设计美形态是华丽,是对象以精致的工艺、昂贵的材质、繁复的组合方式体现出主体与众不同的身份地位的设计美形态。

  1. Structures and Functions of Oligosaccharins

    Energy Technology Data Exchange (ETDEWEB)

    Albersheim, Peter

    1995-12-01

    We have made considerable progress during the 2.5 year funding period just ending in our studies of the structures and functions of oligosaccharide signal molecules (oligosaccharins). We have emphasized studies of the enzymes that solubilize, process, and degrade oligosaccharins and of the proteins that inhibit those enzymes. We have been especially interested in elucidating how oligosaccharins and their processing enzymes participate in determining the outcome of challenges to plants by pathogenic microbes. We have studied, to a lesser extent, the roles of oligosaccharins in plant growth and development. Abstracts of papers describing results acquired with support from this grant that have been published, submitted, or in preparation are presented to summarize the progress made during the last two and one half years. The report highlights the most important contributions made in our oiigosaccharin research during this time period, and the corresponding abstract is referenced. Results of work in progress are described primarily in conjunction with our application for continued support.

  2. Toward a brain-based theory of beauty.

    Science.gov (United States)

    Ishizu, Tomohiro; Zeki, Semir

    2011-01-01

    We wanted to learn whether activity in the same area(s) of the brain correlate with the experience of beauty derived from different sources. 21 subjects took part in a brain-scanning experiment using functional magnetic resonance imaging. Prior to the experiment, they viewed pictures of paintings and listened to musical excerpts, both of which they rated on a scale of 1-9, with 9 being the most beautiful. This allowed us to select three sets of stimuli--beautiful, indifferent and ugly--which subjects viewed and heard in the scanner, and rated at the end of each presentation. The results of a conjunction analysis of brain activity showed that, of the several areas that were active with each type of stimulus, only one cortical area, located in the medial orbito-frontal cortex (mOFC), was active during the experience of musical and visual beauty, with the activity produced by the experience of beauty derived from either source overlapping almost completely within it. The strength of activation in this part of the mOFC was proportional to the strength of the declared intensity of the experience of beauty. We conclude that, as far as activity in the brain is concerned, there is a faculty of beauty that is not dependent on the modality through which it is conveyed but which can be activated by at least two sources--musical and visual--and probably by other sources as well. This has led us to formulate a brain-based theory of beauty.

  3. Success: Talent, Intelligence or Beauty?

    OpenAIRE

    Gergaud, Olivier; Ginsburgh, Victor

    2010-01-01

    We analyze the Celebrity 100 annual list of the world’s most “powerful celebrities” compiled and published by Forbes Magazine. The lists provide an interesting collection of people, that includes their earnings, and the perception of citizens concerning the attributes that made them become celebrities. We analyze the relationship between their earnings and the perceptions on their intelligence, talent, beauty and other attributes, and show that though beauty plays a role, intelligence and tal...

  4. Structure and functions of fungal cell surfaces

    Science.gov (United States)

    Nozawa, Y.

    1984-01-01

    A review with 24 references on the biochemistry, molecular structure, and function of cell surfaces of fungi, especially dermatophytes: the chemistry and structure of the cell wall, the effect of polyene antibiotics on the morphology and function of cytoplasmic membranes, and the chemical structure and function of pigments produced by various fungi are discussed.

  5. Structure Function Estimated From Histological Tissue Sections.

    Science.gov (United States)

    Han, Aiguo; O'Brien, William D

    2016-09-01

    Ultrasonic scattering is determined by not only the properties of individual scatterers but also the correlation among scatterer positions. The role of scatterer spatial correlation is significant for dense medium, but has not been fully understood. The effect of scatterer spatial correlation may be modeled by the structure function as a frequency-dependent factor in the backscatter coefficient (BSC) expression. The structure function has been previously estimated from the BSC data. The aim of this study is to estimate the structure function from histology to test if the acoustically estimated structure function is indeed caused by the scatterer spatial distribution. Hematoxylin and eosin stained histological sections from dense cell pellet biophantoms were digitized. The scatterer positions were determined manually from the histological images. The structure function was calculated from the extracted scatterer positions. The structure function obtained from histology showed reasonable agreement in the shape but not in the amplitude, compared with the structure function previously estimated from the backscattered data. Fitting a polydisperse structure function model to the histologically estimated structure function yielded relatively accurate cell radius estimates ([Formula: see text]). Furthermore, two types of mouse tumors that have similar cell size and shape but distinct cell spatial distributions were studied, where the backscattered data were shown to be related to the cell spatial distribution through the structure function estimated from histology. In conclusion, the agreement between acoustically estimated and histologically estimated structure functions suggests that the acoustically estimated structure function is related to the scatterer spatial distribution.

  6. Novel Structure and Function of Typhoid Toxin

    Science.gov (United States)

    ... Matters NIH Research Matters July 29, 2013 Novel Structure and Function of Typhoid Toxin Structure of typhoid toxin, showing the 2 A subunits ( ... to cultured cells. The scientists next determined the structure of the typhoid toxin. The toxin was already ...

  7. Soft nanotechnology: "structure" vs. "function".

    Science.gov (United States)

    Whitesides, George M; Lipomi, Darren J

    2009-01-01

    This paper offers a perspective on "soft nanotechnology"; that is, the branch of nanotechnology concerned with the synthesis and properties of organic and organometallic nanostructures, and with nanofabrication using techniques in which soft components play key roles. It begins with a brief history of soft nanotechnology. This history has followed a path involving a gradual shift from the promise of revolutionary electronics, nanorobotics, and other futuristic concepts, to the realization of evolutionary improvements in the technology for current challenges in information technology, medicine, and sustainability. Soft nanoscience is an area that is occupied principally by chemists, and is in many ways indistinguishable from "nanochemistry". The paper identifies the natural tendency of its practitioners--exemplified by the speakers at this Faraday Discussion--to focus on synthesis and structure, rather than on function and application, of nanostructures. Soft nanotechnology has the potential to apply to a wide variety of large-scale applied (information technology, healthcare cost reduction, sustainability, energy) and fundamental (molecular biochemistry, cell biology, charge transport in organic matter) problems.

  8. Structure and Function of Lipase

    DEFF Research Database (Denmark)

    Skjold-Jørgensen, Jakob

    Lipases are triacylglycerol hydrolases (EC 3.1.1.3) which are able to act on water-insoluble esters, butdisplay very low activity towards water-soluble, monomeric substrates. This is ascribed to theircharacteristic activation mechanism occurring at the boundary between water and lipid, i.e. the w......Lipases are triacylglycerol hydrolases (EC 3.1.1.3) which are able to act on water-insoluble esters, butdisplay very low activity towards water-soluble, monomeric substrates. This is ascribed to theircharacteristic activation mechanism occurring at the boundary between water and lipid, i.......e. the waterlipidinterface. For Thermomyces lanuginosus lipase (TlL) and related lipases, activation of the enzymeinvolves a rearrangement of a structural domain, called the “lid”, which covers the active site inhomogenous aqueous solution. At the water-lipid interface, the lid is displaced from the active site andmoves...... towards an open conformation enabling the substrate to gain access, thus initiating catalysis.Lipases have been studied for decades and their functional features have drawn much attention withinindustrial applications since their first discovery. However, given that their molecular action takes placeat...

  9. Sleeping Beauties in Meme Diffusion

    CERN Document Server

    Zhang, Leihan; Xu, Ke

    2016-01-01

    A sleeping beauty in diffusion indicates that the information, can be ideas or innovations, will experience a hibernation before a sudden spike of popularity and it is widely found in citation history of scientific publications. However, in this study, we demonstrate that the sleeping beauty is an universal phenomenon in information diffusion and even more inspiring, there exist two consecutive sleeping beauties in the entire lifetime of propagation, suggesting that the information, including trending topics, search queries or Wikipedia views, which we call memes, will go unnoticed for a period and suddenly attracts some attention, and then it falls asleep again and later wakes up with another unexpected popularity peak. Further explorations on this phenomenon show that intervals between two wake ups follow an exponential distribution and the second awakening stage generally reaches its peak at a higher velocity and will bring a wider dissemination. Taking these findings into consideration, the upgraded Bass ...

  10. NYINGCHI,THE NATURAL BEAUTY,AND THE BEAUTY OF NATURE

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    "This beautiful place",Nyingchi,refers to the beauty of mountain ranges,water,valleys,lakes,and even glaciers.No matter how it is defined or named in accordance with tradition, it will never be excessive to credit this place with the description of beautiful;such beauty is barely defined by words.

  11. The Staunch Beauty of Flowers

    Institute of Scientific and Technical Information of China (English)

    1998-01-01

    MANY women like to collect dried flowers. Unable to bear the sight of beautiful blossoms withering, they press them between the leaves of books. As time passes, the original fresh flowers turn into thin pale-colored specimens, but a careful viewer will notice that they have taken on a new grace—just like Ren Jie herself; though no longer young, she has managed to create beauty out of her later life. Ren Jie’s love of flowers dates back to her childhood, when she started to collect flower specimens. As she grew up, she learned how to paint; later, she

  12. Beauty and brains don't mix?

    OpenAIRE

    Fallesen, Krista Bjerknæs; Schultz, Astrid Andrea; Nielsen, Christine Strube; Hansen, Sandra Springborg

    2014-01-01

    This project revolves around beautiful people. There do not exist a recipe for having a beautiful appearance, but we are from childhood as individuals 'coded' to recognize what is beautiful. This project is based on the fact that beautiful people are assigned values that they do not necessarily possess. These values will be described through Pierre Bourdieu's theory about capital and habitus. Some values will be examined especially in relation to one's job situation. Today's labor market will...

  13. Nuclear effects in the structure functions

    Indian Academy of Sciences (India)

    E Marco; E Oset; S K Singh

    2003-11-01

    By using a relativistic framework and accurate nuclear spectral function the structure functions 2 and 3 of deep inelastic charged lepton and neutrino scattering are calculated in nuclei and results are presented.

  14. Performance of Pain, Performance of Beauty

    Science.gov (United States)

    Thompson, James

    2006-01-01

    "Performance of pain, performance of beauty" explores performance projects in war zones using Elaine Scarry's definitions of "pain" and "beauty" as a starting point. The way in which pain constricts the body and the experience that beauty can take a person beyond the body become a contested framework for considering two examples of performance.…

  15. The structure and function of cartilage proteoglycans

    Directory of Open Access Journals (Sweden)

    P J Roughley

    2006-11-01

    Full Text Available Cartilage contains a variety of proteoglycans that are essential for its normal function. These include aggrecan, decorin, biglycan, fibromodulin and lumican. Each proteoglycan serves several functions that are determined by both its core protein and its glycosaminoglycan chains. This review discusses the structure/function relationships of the cartilage proteoglycans, and the manner in which perturbations in proteoglycan structure or abundance can adversely affect tissue function.

  16. YONGJIA,MY BEAUTIFUL HOMETOWN

    Institute of Scientific and Technical Information of China (English)

    袁淑婷; 陈予冰

    2004-01-01

    My hometown Yongjia is a very beautiful place.It is situated in the southeast of Zhejiang Province,on the north bank of the lower Oujiang River.It consists of 14 towns and 28 townships and boasts a total area of 2,698.2 square kilometers.

  17. Beauty in a multicultural world.

    Science.gov (United States)

    Weeks, David M; Thomas, J Regan

    2014-08-01

    The increased demand for facial cosmetic surgery has come from a more diverse, informed, and selective patient population from all walks of life. Virtually no two patients have the same background or cosmetic objectives. However, the classic tenets of beauty including phi, symmetry, averageness, youthfulness, and sexual dimorphism can be applied to persons of all ethnicities to assist in objectifying the abstract concept.

  18. Computers, pattern, chaos and beauty

    CERN Document Server

    Pickover, Clifford A

    1980-01-01

    Combining fractal theory with computer art, this book introduces a creative use of computers. It describes graphic methods for detecting patterns in complicated data and illustrates simple techniques for visualizing chaotic behavior. ""Beautiful."" - Martin Gardner, Scientific American. Over 275 illustrations, 29 in color.

  19. Photon structure function in supersymmetric QCD revisited

    Energy Technology Data Exchange (ETDEWEB)

    Sahara, Ryo, E-mail: sahara@scphys.kyoto-u.ac.jp [Department of Physics, Graduate School of Science, Kyoto University, Kitashirakawa, Kyoto 606-8502 (Japan); Uematsu, Tsuneo, E-mail: uematsu@scphys.kyoto-u.ac.jp [Department of Physics, Graduate School of Science, Kyoto University, Kitashirakawa, Kyoto 606-8502 (Japan); Kitadono, Yoshio, E-mail: kitadono@phys.sinica.edu.tw [Institute of Physics, Academia Sinica, Taipei, Taiwan (China)

    2012-02-07

    We investigate the virtual photon structure function in the supersymmetric QCD (SQCD), where we have squarks and gluinos in addition to the quarks and gluons. Taking into account the heavy particle mass effects to the leading order in QCD and SQCD we evaluate the photon structure function and numerically study its behavior for the QCD and SQCD cases.

  20. Photon Structure Function in Supersymmetric QCD Revisited

    CERN Document Server

    Sahara, Ryo; Kitadono, Yoshio

    2011-01-01

    We investigate the virtual photon structure function in the supersymmetric QCD (SQCD), where we have squarks and gluinos in addition to the quarks and gluons. Taking into account the heavy particle mass effects to the leading order in QCD and SQCD we evaluate the photon structure function and numerically study its behavior for the QCD and SQCD cases.

  1. WAY TO DETERMINE STIFFNESS FUNCTION OF STRUCTURE

    Institute of Scientific and Technical Information of China (English)

    WANG De-ming; GAI Bing-zheng

    2005-01-01

    For calculating the stiffness function of a structure, the differential equation of the vibration of the structure was divided into the differential equation on the original stiffness function that was known, and Fredholm integral equation of the first kind on the undetermined stiffness function that was unknown. And the stable solutions of the integral equation, when the smooth factor was equal to zero, was solved by the extrapolation with p smooth factors. So the stiffness function of the structure is obtained. Applied examples show that the method is feasible and effective.

  2. Mathematical beauty in service of deep approach to learning

    DEFF Research Database (Denmark)

    Karamehmedovic, Mirza

    2015-01-01

    , emphasising the beauty of the underlying mathematical structure. Into this I integrated frequent and activating dialogue with the students. In section 1 I describe the course and the students in more detail. Section 2 details and justifies the pedagogical elements I introduced into the lectures; my central...

  3. A foxy view of human beauty: implications of the farm fox experiment for understanding the origins of structural and experiential aspects of facial attractiveness.

    Science.gov (United States)

    Elia, I E

    2013-09-01

    Within 20 years, experimental selection of quantified "not too aggressive, not too fearful" behavior to human approach was shown in silver foxes (Vulpes vulpes) to produce a neotenic package of traits in adults: ability to seek, induce, and sustain contact (called friendly or rapport behavior); relatively short limbs and foreshortened skull/face; and light pigmentation areas. Earlier sexual maturation, prolonged receptivity, and larger litters were also noted. The increased estradiol supporting these changes was apparently also responsible for faster skeletal maturation, including earlier fusion of the basicranium causing tooth crowding, but also paedomorphic craniofacial proportions that we find attractive in our own and other species. In this paper, these important findings of the farm fox experiment are juxtaposed with insights from social psychology, physical anthropology, and neuroscience about facial beauty and reaction to it. Since many unrelated species show some or all of the neotenic package or domestication profile when they have achieved rapport past the juvenile stage, craniofacial proportions considered attractive are discussed as genetically and hormonally linked to the evolution of rapport--social contact, trust, and cooperation--whether by natural, intuitive, intentional, or mixed paths of selection.

  4. Structure and function in flow networks

    CERN Document Server

    Rubido, Nicolás; Baptista, Murilo S

    2013-01-01

    This Letter presents a unified approach for the fundamental relationship between structure and function in flow networks by solving analytically the voltages in a resistor network, transforming the network structure to an effective all-to-all topology, and then measuring the resultant flows. Moreover, it defines a way to study the structural resilience of the graph and to detect possible communities.

  5. Nitrogenase structure and function relationships by density functional theory.

    Science.gov (United States)

    Harris, Travis V; Szilagyi, Robert K

    2011-01-01

    Modern density functional theory has tremendous potential with matching popularity in metalloenzymology to reveal the unseen atomic and molecular details of structural data, spectroscopic measurements, and biochemical experiments by providing insights into unobservable structures and states, while also offering theoretical justifications for observed trends and differences. An often untapped potential of this theoretical approach is to bring together diverse experimental structural and reactivity information and allow for these to be critically evaluated at the same level. This is particularly applicable for the tantalizingly complex problem of the structure and molecular mechanism of biological nitrogen fixation. In this chapter we provide a review with extensive practical details of the compilation and evaluation of experimental data for an unbiased and systematic density functional theory analysis that can lead to remarkable new insights about the structure-function relationships of the iron-sulfur clusters of nitrogenase.

  6. Beauty in photoproduction at HERA II with the ZEUS detector

    Energy Technology Data Exchange (ETDEWEB)

    Boutle, Sarah

    2010-02-15

    The production of beauty quarks in ep collisions should be accurately calculable in perturbative Quantum Chromodynamics (QCD) since the large mass of the b quark provides a hard scale. Therefore it is interesting to compare such predictions to results using photoproduction events where a low-virtuality photon, emitted by the incoming lepton, collides with a parton from the incoming proton. A measurement of beauty in photoproduction has been made at HERA with the ZEUS detector using an integrated luminosity of 126 pb{sup -}1. Beauty was identified in events with a muon in the final state by using the transverse momentum of the muon relative to the closest jet. Lifetime information from the silicon vertex detector was also used; the impact parameter of the muon with respect to the primary vertex was exploited to discriminate between signal and background. Cross sections for beauty production as a function of the muon and the jet variables were measured and compared to QCD predictions and to previous measurements. The data were found to be well described by the predictions from next-to-leading-order QCD. The dijet sample of beauty photoproduction events was also used to study higher-order QCD topologies. At leading order, the two jets in the event are produced back-to-back in azimuthal angle, such that {delta}{phi}{sup jj}={phi}{sup j1}-{phi}{sup j2}={pi}. Additional soft radiation causes small azimuthal decorrelations, whilst {delta}{phi}{sup jj} significantly lower than {pi} is evidence of additional hard radiation. In this thesis, the cross section versus {delta}{phi}{sup jj} for beauty photoproduction and the comparison to NLO QCD predictions and Monte Carlo models are presented. (orig.)

  7. The beauty and the beast inside: the american beauty--does cosmetic surgery help?

    Science.gov (United States)

    Lijtmaer, Ruth

    2010-01-01

    American society's feminine ideal has consistently emphasized youth as beauty and getting old as ugly. Feeling unattractive produces several intrapsychic conflicts leading to depression and anxiety. Summary of the literature on beauty and aging, beauty and culture, and theories of physical beauty will be presented. With a clinical example of a female patient, the writer investigates the conscious and unconscious fantasies, conflicts, and sense of self inside and outside that impelled a physically beautiful female patient to bring her own body closer to her perception of idealized beauty with the aid of plastic surgery.

  8. The neural correlates of beauty comparison.

    Science.gov (United States)

    Kedia, Gayannée; Mussweiler, Thomas; Mullins, Paul; Linden, David E J

    2014-05-01

    Beauty is in the eye of the beholder. How attractive someone is perceived to be depends on the individual or cultural standards to which this person is compared. But although comparisons play a central role in the way people judge the appearance of others, the brain processes underlying attractiveness comparisons remain unknown. In the present experiment, we tested the hypothesis that attractiveness comparisons rely on the same cognitive and neural mechanisms as comparisons of simple nonsocial magnitudes such as size. We recorded brain activity with functional magnetic resonance imaging (fMRI) while participants compared the beauty or height of two women or two dogs. Our data support the hypothesis of a common process underlying these different types of comparisons. First, we demonstrate that the distance effect characteristic of nonsocial comparisons also holds for attractiveness comparisons. Behavioral results indicated, for all our comparisons, longer response times for near than far distances. Second, the neural correlates of these distance effects overlapped in a frontoparietal network known for its involvement in processing simple nonsocial quantities. These results provide evidence for overlapping processes in the comparison of physical attractiveness and nonsocial magnitudes.

  9. Facial beauty and fractal geometry

    OpenAIRE

    Schmidhuber, Juergen

    1998-01-01

    What is it that makes a face beautiful? Average faces obtained by photographic (Galton 1878) or digital (Langlois & Roggman 1990) blending are judged attractive but not optimally attractive (Alley & Cunningham 1991) --- digital exaggerations of deviations from average face blends can lead to higher attractiveness ratings (Perrett, May, & Yoshikawa 1994). My novel approach to face design does not involve blending at all. Instead, the image of a female face with high ratings is composed from a ...

  10. Progress on nuclear modifications of structure functions

    CERN Document Server

    Kumano, S

    2016-01-01

    We report progress on nuclear structure functions, especially on their nuclear modifications and a new tensor structure function for the deuteron. To understand nuclear structure functions is an important step toward describing nuclei and QCD matters from low to high densities and from low to high energies in terms of fundamental quark and gluon degrees of freedom beyond conventional hadron and nuclear physics. It is also practically important for understanding new phenomena in high-energy heavy-ion collisions at RHIC and LHC. Furthermore, since systematic errors of current neutrino-oscillation experiments are dominated by uncertainties of neutrino-nucleus interactions, such studies are valuable for finding new physics beyond current framework. Next, a new tensor-polarized structure function $b_1$ is discussed for the deuteron. There was a measurement by HERMES; however, its data are inconsistent with the conventional convolution estimate based on the standard deuteron model with D-state admixture. This fact ...

  11. Structural and functional properties of designed globins

    Indian Academy of Sciences (India)

    Yasuhiro Isogai; Anna Ishii; Manabu Ishida; Masahiro Mukai; Motonori Ota; Ken Nishikawa; Tetsutaro Iizuka

    2000-06-01

    De novo design of artificial proteins is an essential approach to elucidate the principles of protein architecture and to understand specific functions of natural proteins and also to yield novel molecules for medical and industrial aims. We have designed artificial sequences of 153 amino acids to fit the main-chain framework of the sperm whale myoglobin structure based on the knowledge-based energy functions to evaluate the compatibility between protein tertiary structures and amino acid sequences. The synthesized artificial globins bind a single heme per protein molecule as designed, which show well-defined electrochemical and spectroscopic features characteristic of proteins with a low-spin heme. Redox and ligand binding reactions of the artificial heme proteins were investigated and these heme-related functions were found to vary with their structural uniqueness. Relationships between the structural and functional properties are discussed.

  12. Understanding Microbial Communities: Function, Structure and Dynamics

    Science.gov (United States)

    2015-02-11

    microbial communities: Function, structure and dynamics’, at the Isaac Newton Institute, University of Cambridge, United Kingdom, from August to...dynamics’, at the Isaac Newton Institute, University of Cambridge, United Kingdom, from August to December 2014. The programme involved over 150...Communities: Function, Structure and Dynamics’, at the Isaac Newton Institute, Cambridge University, UK, from 19th August 2014 – 19th December 2014

  13. Recent Structure Function Results from CCFR

    CERN Document Server

    Fleming, B T; Alton, A; Arroyo, C G; Avvakumov, S; De Barbaro, L; De Barbaro, P; Bazarko, A O; Bernstein, R H; Bodek, Arie; Bolton, T; Brau, J E; Buchholz, D; Budd, H S; Bugel, L; Conrad, J; Drucker, R B; Formaggio, J A; Frey, R; Goldman, J; Goncharov, M; Harris, D A; Johnson, R A; Kim, J H; King, B J; Kinnel, T; Koutsoliotas, S; Lamm, M J; Marsh, W; Mason, D; McFarland, K S; McNulty, C; Mishra, S R; Naples, D; Nienaber, P; Romosan, A; Sakumoto, W K; Schellman, H; Sciulli, F J; Seligman, W G; Shaevitz, M H; Smith, W H; Spentzouris, P; Stern, E G; Vakili, M; Vaitaitis, A G; Yang, U K; Yu, J; Zeller, G P; Zimmerman, E D

    2000-01-01

    A new structure function analysis of CCFR deep inelastic nu-N and nubar-N scattering data is presented for previously unexplored kinematic regions down to Bjorken x=0.0045 and Q^2=0.3 GeV^2. Comparisons to charged lepton scattering data from NMC and E665 experiments are made and the behavior of the structure function F2_nu is studied in the limit Q^2 -> 0

  14. Polarized deuteron structure functions at small x

    CERN Document Server

    Edelmann, J; Weise, W

    1997-01-01

    We investigate shadowing corrections to the polarized deuteron structure functions g_1^d and b_1. In the kinematic domain of current fixed target experiments we observe that shadowing effects in g_1^d are approximately twice as large as for the unpolarized structure function F_2^d. Furthermore, we find that b_1 is surprisingly large at x < 0.1 and receives dominant contributions from coherent double scattering.

  15. [Snake venom metalloproteinases: structure, biosynthesis and function(s)].

    Science.gov (United States)

    Limam, I; El Ayeb, M; Marrakchi, N

    2010-01-01

    The biochemical and the pharmacological characterization of snake venoms revealed an important structural and functional polymorphism of proteins which they contain. Among them, snake venom metalloproteases (SVMPs) constitute approximatively 20 to 60% of the whole venom proteins. During the last decades, a significant progress was performed against structure studies and the biosynthesis of the SVMPs. Indeed, several metalloproteases were isolated and characterized against their structural and pharmacological properties. In this review, we report the most important properties concerning the classification, the structure of the various domains of the SVMPs as well as their biosynthesis and their activities as potential therapeutic agents.

  16. Zinc finger structure-function in Ikaros

    Institute of Scientific and Technical Information of China (English)

    Marvin; A; Payne

    2011-01-01

    The zinc finger motif was used as a vehicle for the initial discovery of Ikaros in the context of T-cell differentiation and has been central to all subsequent analyses of Ikaros function.The Ikaros gene is alternately spliced to produce several isoforms that confer diversity of function and consequently have complicated analysis of the function of Ikaros in vivo.Key features of Ikaros in vivo function are associated with six C2H2 zinc fingers;four of which are alternately incorporated in the production of the various Ikaros isoforms.Although no complete structures are available for the Ikaros protein or any of its family members,considerable evidence has accumulated about the structure of zinc fingers and the role that this structure plays in the functions of the Ikaros family of proteins.This review summarizes the structural aspects of Ikaros zinc fingers,individually,and in tandem to provide a structural context for Ikaros function and to provide a structural basis to inform the design of future experiments with Ikaros and its family members.

  17. Next-order structure-function equations

    Science.gov (United States)

    Hill, Reginald J.; Boratav, Olus N.

    2001-01-01

    Kolmogorov's equation [Dokl. Akad. Nauk SSSR 32, 16 (1941)] relates the two-point second- and third-order velocity structure functions and the energy dissipation rate. The analogous next higher-order two-point equation relates the third- and fourth-order velocity structure functions and the structure function of the product of pressure-gradient difference and two factors of velocity difference, denoted Tijk. The equation is simplified on the basis of local isotropy. Laboratory and numerical simulation data are used to evaluate and compare terms in the equation, examine the balance of the equation, and evaluate components of Tijk. Atmospheric surface-layer data are used to evaluate Tijk in the inertial range. Combined with the random sweeping hypothesis, the equation relates components of the fourth-order velocity structure function. Data show the resultant error of this application of random sweeping. The next-order equation constrains the relationships that have been suggested among components of the fourth-order velocity structure function. The pressure structure function, pressure-gradient correlation, and mean-squared pressure gradient are related to Tijk. Inertial range formulas are discussed.

  18. Structure and Structure-activity Relationship of Functional Organic Molecules

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    @@ Research theme The group is made up of junior scientists from the State Key Laboratory of Elemento-organic Chemistry, Nankai University.The scientists focus their studis on the structure and structure-activity relationship of functional organic molecules not only because it has been the basis of their research, but also because the functional study of organic compounds is now a major scientific issue for organic chemists around the world.

  19. Performing Beauty in Participatory Art and Culture

    DEFF Research Database (Denmark)

    Heinrich, Falk

    This book investigates the notion of beauty in participatory art, an interdisciplinary form that necessitates the audience’s agential participation and that is often seen in interactive art and technology-driven media installations. After considering established theories of beauty, for example......, Plato, Alison, Hume, Kant, Gadamer and Santayana through to McMahon and Sartwell, Heinrich argues that the experience of beauty in participatory art demands a revised notion of beauty; a conception that accounts for the performative and ludic turn within various art forms and which is, in a broader...... sense, a notion of beauty suited to a participatory and technology-saturated culture. Through case studies of participatory art, he provides an art-theoretical approach to the concept of performative beauty; an approach that is then applied to the wider context of media and design artefacts....

  20. Huntington's disease : functional and structural biomarkers

    NARCIS (Netherlands)

    Dumas, Eve Marie

    2012-01-01

    The aims of this thesis were to gain insight into specific disease processes in Huntington’s Disease (HD) and to identify biomarkers. To achieve these aims, cognitive functioning, structural brain characteristics and intrinstic functional brain connectivity of premanifest and early HD subjects were

  1. 2004 Structural, Function and Evolutionary Genomics

    Energy Technology Data Exchange (ETDEWEB)

    Douglas L. Brutlag Nancy Ryan Gray

    2005-03-23

    This Gordon conference will cover the areas of structural, functional and evolutionary genomics. It will take a systematic approach to genomics, examining the evolution of proteins, protein functional sites, protein-protein interactions, regulatory networks, and metabolic networks. Emphasis will be placed on what we can learn from comparative genomics and entire genomes and proteomes.

  2. Structure functions in the chiral bag model

    Energy Technology Data Exchange (ETDEWEB)

    Sanjose, V.; Vento, V.

    1989-07-13

    We calculate the structure functions of an isoscalar nuclear target for the deep inelastic scattering by leptons in an extended version of the chiral bag model which incorporates the qanti q structure of the pions in the cloud. Bjorken scaling and Regge behavior are satisfied. The model calculation reproduces the low-x behavior of the data but fails to explain the medium- to large-x behavior. Evolution of the quark structure functions seem inevitable to attempt a connection between the low-energy models and the high-energy behavior of quantum chromodynamics. (orig.).

  3. Predicting protein structure classes from function predictions

    DEFF Research Database (Denmark)

    Sommer, I.; Rahnenfuhrer, J.; de Lichtenberg, Ulrik;

    2004-01-01

    We introduce a new approach to using the information contained in sequence-to-function prediction data in order to recognize protein template classes, a critical step in predicting protein structure. The data on which our method is based comprise probabilities of functional categories; for given...... query sequences these probabilities are obtained by a neural net that has previously been trained on a variety of functionally important features. On a training set of sequences we assess the relevance of individual functional categories for identifying a given structural family. Using a combination...... of the most relevant categories, the likelihood of a query sequence to belong to a specific family can be estimated. Results: The performance of the method is evaluated using cross-validation. For a fixed structural family and for every sequence, a score is calculated that measures the evidence for family...

  4. Magnetism and Structure in Functional Materials

    CERN Document Server

    Planes, Antoni; Saxena, Avadh

    2005-01-01

    Magnetism and Structure in Functional Materials addresses three distinct but related topics: (i) magnetoelastic materials such as magnetic martensites and magnetic shape memory alloys, (ii) the magnetocaloric effect related to magnetostructural transitions, and (iii) colossal magnetoresistance (CMR) and related magnanites. The goal is to identify common underlying principles in these classes of materials that are relevant for optimizing various functionalities. The emergence of apparently different magnetic/structural phenomena in disparate classes of materials clearly points to a need for common concepts in order to achieve a broader understanding of the interplay between magnetism and structure in this general class of new functional materials exhibiting ever more complex microstructure and function. The topic is interdisciplinary in nature and the contributors correspondingly include physicists, materials scientists and engineers. Likewise the book will appeal to scientists from all these areas.

  5. Clustering aspects in nuclear structure functions

    CERN Document Server

    Hirai, M; Saito, K; Watanabe, T

    2010-01-01

    For understanding an anomalous nuclear effect experimentally observed for the beryllium-9 nucleus at the Thomas Jefferson National Accelerator Facility (JLab), clustering aspects are studied in structure functions of deep inelastic lepton-nucleus scattering by using momentum distributions calculated in antisymmetrized (or fermionic) molecular dynamics (AMD) and also in a simple shell model for comparison. According to the AMD, the Be-9 nucleus consists of two alpha-like clusters with a surrounding neutron. The clustering produces high-momentum components in nuclear wave functions, which affects nuclear modifications of the structure functions. We investigated whether clustering features could appear in the structure function F_2 of Be-9 along with studies for other light nuclei. We found that nuclear modifications of F_2 are similar in both AMD and shell models within our simple convolution description although there are slight differences in Be-9. It indicates that the anomalous Be-9 result should be explain...

  6. The proteome: structure, function and evolution.

    Science.gov (United States)

    Fleming, Keiran; Kelley, Lawrence A; Islam, Suhail A; MacCallum, Robert M; Muller, Arne; Pazos, Florencio; Sternberg, Michael J E

    2006-03-29

    This paper reports two studies to model the inter-relationships between protein sequence, structure and function. First, an automated pipeline to provide a structural annotation of proteomes in the major genomes is described. The results are stored in a database at Imperial College, London (3D-GENOMICS) that can be accessed at www.sbg.bio.ic.ac.uk. Analysis of the assignments to structural superfamilies provides evolutionary insights. 3D-GENOMICS is being integrated with related proteome annotation data at University College London and the European Bioinformatics Institute in a project known as e-protein (http://www.e-protein.org/). The second topic is motivated by the developments in structural genomics projects in which the structure of a protein is determined prior to knowledge of its function. We have developed a new approach PHUNCTIONER that uses the gene ontology (GO) classification to supervise the extraction of the sequence signal responsible for protein function from a structure-based sequence alignment. Using GO we can obtain profiles for a range of specificities described in the ontology. In the region of low sequence similarity (around 15%), our method is more accurate than assignment from the closest structural homologue. The method is also able to identify the specific residues associated with the function of the protein family.

  7. Structure and Functions of Linker Histones.

    Science.gov (United States)

    Lyubitelev, A V; Nikitin, D V; Shaytan, A K; Studitsky, V M; Kirpichnikov, M P

    2016-03-01

    Linker histones such as variants H1, H5, and other similar proteins play an important role in regulation of chromatin structure and dynamics. However, interactions of linker histones with DNA and proteins, as well as specific functions of their different variants, are poorly studied. This is because they acquire tertiary structure only when interacting with a nucleosome, and because of limitations of currently available methods. However, deeper investigation of linker histones and their interactions with other proteins will address a number of important questions - from structure of compacted chromatin to regulation of early embryogenesis. In this review, structures of histone H1 variants and its interaction with chromatin DNA are considered. A possible functional significance of different H1 variants, a role of these proteins in maintaining interphase chromatin structure, and interactions of linker histones with other cellular proteins are also discussed.

  8. Hadron spectroscopy from strangeness to charm and beauty

    Energy Technology Data Exchange (ETDEWEB)

    Zou, B.S., E-mail: zoubs@ihep.ac.cn [State Key Laboratory of Theoretical Physics, Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 100190 (China); Institute of High Energy Physics and Theoretical Physics Center for Science Facilities, Chinese Academy of Sciences, Beijing 100049 (China)

    2013-09-20

    Quarks of different flavors have different masses, which will cause breaking of flavor symmetries of QCD. Flavor symmetries and their breaking in hadron spectroscopy play important role for understanding the internal structures of hadrons. Hadron spectroscopy with strangeness reveals the importance of unquenched quark dynamics. Systematic study of hadron spectroscopy with strange, charm and beauty quarks would be very revealing and essential for understanding the internal structure of hadrons and its underlying quark dynamics.

  9. Pavilion Analysis of "Pavilion":An Analysis of Function and Artistic Conception Beauty of Pavilion from the Perspective of Classical Landscape Painting and Poems%亭“亭”论--以古典山水画与诗词文赋视角论亭的功能及意境美

    Institute of Scientific and Technical Information of China (English)

    梁富新

    2015-01-01

    亭作为中国古典园林艺术中兼具实用和艺术审美的建筑艺术种类,其功能结构与物质实体自古至今已有巨大变化。同时,亭的艺术审美形象及其意境美也随之改变。由于对园林中“物质之亭”的论述已很丰富,因此选取纯粹艺术领域——古典山水画与诗词文赋中的“亭”,对其进行审美形象和意境的分析,则更具有建设性的意义。%As a type of architectural art which has both practical and artistic aesthetics in Chinese classical garden art, the functional structure and material reality of pavilion has changed a lot from of old until in now. At the same time, the pavilion's aesthetic image and artistic conception beauty have also changed accordingly. Due to that the discussions about“material pavilion”in the garden have been abundant enough, so it is of more constructive signiifcance to select the"Pavilion"in the pure artistic area, such as the“Pavilion”in classical landscape paintings and poems and analyze the aesthetic image and artistic conception.

  10. GRASPs in Golgi Structure and Function

    Directory of Open Access Journals (Sweden)

    Xiaoyan eZhang

    2016-01-01

    Full Text Available The Golgi apparatus is a central intracellular membrane organelle for trafficking and modification of proteins and lipids. Its basic structure is a stack of tightly aligned flat cisternae. In mammalian cells, dozens of stacks are concentrated in the pericentriolar region and laterally connected to form a ribbon. Despite extensive research in the last decades, how this unique structure is formed and why its formation is important for proper Golgi functioning remain largely unknown. The Golgi ReAssembly Stacking Proteins, GRASP65 and GRASP55, are so far the only proteins shown to function in Golgi stacking. They are peripheral membrane proteins on the cytoplasmic face of the Golgi cisternae that form trans-oligomers through their N-terminal GRASP domain, and thereby function as the glue to stick adjacent cisternae together into a stack and to link Golgi stacks into a ribbon. Depletion of GRASPs in cells disrupts the Golgi structure and results in accelerated protein trafficking and defective glycosylation. In this minireview we summarize our current knowledge on how GRASPs function in Golgi structure formation and discuss why Golgi structure formation is important for its function.

  11. Deep Inelastic Structure Functions at small x

    CERN Document Server

    Ermolaev, B I; Troyan, S I

    2006-01-01

    Explicit expressions for the non-singlet and singlet structure functions g_1 in the small-x region are obtained. They include the total resummation of the double- and single- logarithms of x and account for the running QCD coupling effects. Both the non-singlet and singlet structure functions are Regge behavied asymptotically, with the intercepts predicted in agreement with experiments. A detailed comparison with the DGLAP evolution equations for different values of x and Q^2 is performed. Finally, the role played by singular terms in DGLAP fits is discussed and explicitly shown to mimic the resummation of leading logarithms at small x.

  12. Structural and functional insights into Mimivirus ORFans

    Directory of Open Access Journals (Sweden)

    Fischer Daniel

    2007-05-01

    Full Text Available Abstract Background Mimivirus isolated from A. polyphaga is the largest virus discovered so far. It is unique among all the viruses in having genes related to translation, DNA repair and replication which bear close homology to eukaryotic genes. Nevertheless, only a small fraction of the proteins (33% encoded in this genome has been assigned a function. Furthermore, a large fraction of the unassigned protein sequences bear no sequence similarity to proteins from other genomes. These sequences are referred to as ORFans. Because of their lack of sequence similarity to other proteins, they can not be assigned putative functions using standard sequence comparison methods. As part of our genome-wide computational efforts aimed at characterizing Mimivirus ORFans, we have applied fold-recognition methods to predict the structure of these ORFans and further functions were derived based on conservation of functionally important residues in sequence-template alignments. Results Using fold recognition, we have identified highly confident computational 3D structural assignments for 21 Mimivirus ORFans. In addition, highly confident functional predictions for 6 of these ORFans were derived by analyzing the conservation of functional motifs between the predicted structures and proteins of known function. This analysis allowed us to classify these 6 previously unannotated ORFans into their specific protein families: carboxylesterase/thioesterase, metal-dependent deacetylase, P-loop kinases, 3-methyladenine DNA glycosylase, BTB domain and eukaryotic translation initiation factor eIF4E. Conclusion Using stringent fold recognition criteria we have assigned three-dimensional structures for 21 of the ORFans encoded in the Mimivirus genome. Further, based on the 3D models and an analysis of the conservation of functionally important residues and motifs, we were able to derive functional attributes for 6 of the ORFans. Our computational identification of important

  13. Simple Algorithmic Principles of Discovery, Subjective Beauty, Selective Attention, Curiosity & Creativity

    CERN Document Server

    Schmidhuber, Juergen

    2007-01-01

    I postulate that human or other intelligent agents function or should function as follows. They store all sensory observations as they come - the data is holy. At any time, given some agent's current coding capabilities, part of the data is compressible by a short and hopefully fast program / description / explanation / world model. In the agent's subjective eyes, such data is more regular and more "beautiful" than other data. It is well-known that knowledge of regularity and repeatability may improve the agent's ability to plan actions leading to external rewards. In absence of such rewards, however, known beauty is boring. Then "interestingness" becomes the first derivative of subjective beauty: as the learning agent improves its compression algorithm, formerly apparently random data parts become subjectively more regular and beautiful. Such progress in compressibility is measured and maximized by the curiosity drive: create action sequences that extend the observation history and yield previously unknown /...

  14. Free Harmonious Beauty of Greek Sculpture

    Institute of Scientific and Technical Information of China (English)

    郑晓杨

    2015-01-01

    Greek art in the content and form of the art of the beautiful, harmonious effect fully expresses the interpretation of the height of the spirit of freedom, and the Greek sculpture is a powerful representative of Greek art. In this paper, from a few large sculpture art to savor the Greek sculpture artistic freedom and harmonious beauty.

  15. Is Beauty an Archaic Spirit in Education?

    Science.gov (United States)

    Cannatella, Howard

    2006-01-01

    This article discusses the unfashionable and taboo idea that beauty matters. The author's supposition is that beauty as a poetic force should be regarded as one of the defining characteristics central to pedagogic practice. In making this claim he draws upon a few of Charles Dickens' and William Wordsworth's ideas in support of the importance of…

  16. ATTRACTION OF STUDENTS TOWARDS BEAUTY PRODUCTS

    Directory of Open Access Journals (Sweden)

    Fouzia Ali

    2011-07-01

    Full Text Available The purpose of this study was to measure the correlation and impact of deceptive beauty advertising (Ads with and on the buying behavior of the university students toward beauty products. Developed instrument contained nineteen questions. Five point Likert scale was used and the response rate was 94.667%. Two variables were computed; buying behavior of university students towards beauty products was dependent variable; and deceptive beauty ads were independent variable. Descriptive statistics, correlation and liner regression techniques were used with the help of SPSS 16. Positive and significant correlation and impact was found with and on the buying behavior of university students toward beauty products which means that the use of beauty products increases with the increase in deception in beauty products ads. The data were collected from university students and non-serious attitude of students were the limitations of this study. In this study, the main focus was on the buying behavior of students and beauty products ads, and it will serve as a benchmark for prospective researchers for future study.

  17. The structure of bivariate rational hypergeometric functions

    CERN Document Server

    Cattani, Eduardo; Villegas, Fernando Rodriguez

    2009-01-01

    We describe the structure of all codimension-two lattice configurations $A$ which admit a stable rational $A$-hypergeometric function, that is a rational function $F$ all whose partial derivatives are non zero, and which is a solution of the $A$-hypergeometric system of partial differential equations defined by Gel'fand, Kapranov and Zelevinsky. We show, moreover, that all stable rational $A$-hypergeometric functions may be described by toric residues and apply our results to study the rationality of bivariate series whose coefficients are quotients of factorials of linear forms.

  18. Progress on nuclear modifications of structure functions

    Directory of Open Access Journals (Sweden)

    Kumano S.

    2016-01-01

    Full Text Available We report progress on nuclear structure functions, especially on their nuclear modifications and a new tensor structure function for the deuteron. To understand nuclear structure functions is an important step toward describing nuclei and QCD matters from low to high densities and from low to high energies in terms of fundamental quark and gluon degrees of freedom beyond conventional hadron and nuclear physics. It is also practically important for understanding new phenomena in high-energy heavy-ion collisions at RHIC and LHC. Furthermore, since systematic errors of current neutrinooscillation experiments are dominated by uncertainties of neutrino-nucleus interactions, such studies are valuable for finding new physics beyond current framework. Next, a new tensor-polarized structure function b1 is discussed for the deuteron. There was a measurement by HERMES; however, its data are inconsistent with the conventional convolution estimate based on the standard deuteron model with D-state admixture. This fact suggests that a new hadronic phenomenon should exist in the tensor-polarized deuteron at high energies, and it will be experimentally investigated at JLab from the end of 2010’s.

  19. Structural Functionalism as a Heuristic Device.

    Science.gov (United States)

    Chilcott, John H.

    1998-01-01

    Argues that structural functionalism as a method for conducting fieldwork and as a format for the analysis of ethnographic data remains a powerful model, one that is easily understood by professional educators. As a heuristic device, functionalist theory can help in the solution of a problem that is otherwise incapable of theoretical…

  20. [Structure and functions of glutathione transferases].

    Science.gov (United States)

    Fedets, O M

    2014-01-01

    Data about classification, nomenclature, structure, substrate specificity and role of many glutathione transferase's isoenzymes in cell functions have been summarised. The enzyme has been discovered more than 50 years ago. This family of proteins is updated continuously. It has very different composition and will have demand for system analysis for many years.

  1. Polynomial Structure of Topological String Partition Functions

    CERN Document Server

    Zhou, Jie

    2015-01-01

    We review the polynomial structure of the topological string partition functions as solutions to the holomorphic anomaly equations. We also explain the connection between the ring of propagators defined from special K\\"ahler geometry and the ring of almost-holomorphic modular forms defined on modular curves.

  2. Contributions of Consumer-perceived Creativity and Beauty to Willingness-to-pay for Design Products

    DEFF Research Database (Denmark)

    Christensen, Bo Thomas; Kristensen, Tore; Reber, Rolf

    2015-01-01

    Consumer perception of creativity in design products equivalent in function was measured using global single-item ratings of creativity. The measure was found to have a high level of agreement between raters and have discriminant validity to another aesthetic construct, that of beauty. In two exp...... models of creativity and beauty evaluations in consumer psychology, in that they seem to be distinct factors, explaining different parts of the variance in their consequences on WtP....

  3. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Kidd Ji

    2010-01-01

    <正>01逆转光老化>光老化是目前被认为肌肤衰老的最大元凶。有害的紫外线深入肌肤深处,直接伤害细胞DNA,破坏肌肤自我更新过程,同时引发自由基,对肌肤造成进一步的间接伤害。在美国,激光被运用在光老化引起的皱纹、松弛的肌肤治疗上,因为术后红肿的反应并不多,所以很多人都能接受。但你需要为之付出疼痛感和一到两万元的高额费用。随着美容产品技术的提高与开发,基于医学美容的CLINIQUE

  4. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie Kwok

    2012-01-01

    <正>01皇室御用彩妆盒〉Cle de peau Beaute邀得皇室御用珠宝设计师Shaun Leane,为春夏特别推出的Luminizing Face Enhancer设计一个闪烁夺目的盒子。Shaun Leane曾任皇室御用珠宝师及Alexander McQueen的首席珠宝设计师。他是英国FlPG获奖者,该奖项专门表扬技术超凡的珠宝匠师。精美闪烁的宝石切割面粉盒,一丝不苟的设计,令彩妆盒精致如珠宝盒一样,带有高贵优雅气派。Shaun Leane指出:"最初构思包装设计时,第一个念头是塑造既富触感又美观的盒子。在美感方面,我们希望设计宛如一件多琢面的

  5. Beauty

    Institute of Scientific and Technical Information of China (English)

    Jasmine; Chris

    2010-01-01

    <正>03Jean Paul Gaultier 2010春夏高级订制:梦游"奇幻乐园"〉老顽童Jean Paul Gaultier这次给彩妆大师Tom Pecheux出了一个趣味横生的妆容课题—fantasy land。于是Tom Pecheux把墨西哥人、外星人、甚至是热映的电影《Avatar》都搬上了T台。模特们的妆容被大自然的缤纷色彩所填满,限部以天空蓝、植物绿、夕阳橙和大地黄为

  6. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie; Kwok

    2011-01-01

    <正>01从不泛黄的照片谈美白>现在什么都谈数码化,数码相机的科技水平也越来越高,但是十分值得纪念的相片,还是会有冲印出来的冲动。富士牌的相机胶卷你一定听过用过吧,用它冲印出来的相片,不论经过多少年,相片上的颜色不只没有泛黄,更没有褪色。原来,照相的相机胶卷是用骨胶原制成的。相同道理,如果富士能将相机胶卷用的骨胶原保持最佳状态,它们亦会知道怎样保护我们皮肤的骨胶原。所以当富士推出Fijifilm beauty系列,对女士们来说,可谓福音!

  7. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie; Kwok

    2011-01-01

    <正>01有机"炼金术">古时人们相信可以从金属中提炼长生不老的丹药,虽然现代科学已证实炼金术不能提炼所谓"仙丹",但却令人类对物质和化学有了进一步的认识和了解。因为这些知识,让我们可以从自然环境中萃取各种天然成分,合成及研发成各种不只对皮肤或身体有益的产品,更有效地减少了浪费和不必要的消耗。

  8. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Kidd Ji

    2010-01-01

    <正>01Rene Gruau与美妆传承法国画家Rene Gruau的重要,不仅来自他独特的虚实结合水彩风格,将东西方绘画艺术相结合,令20世纪中期的人们耳目一新。他与Dior品牌合作,让插画与Dior在50年代推出的"New Look"风格紧密结合,流畅大气的线条勾勒出明显的女性曲线,修身、高雅、大气,这些插画与人们脑中的Dior服饰产生了不可分割的联系。2010年11月10日至2011年1月9日,名为"Dior插画展:Rene Gruau与美妆传承"的展览将于伦敦萨默塞特宫隆重举行。这场展览将向公众展现里程碑式的艺术珍品,荟集了经严格甄选的Dior高级定制礼服,以及Gruau特别为Dior香水化妆品品牌、古董香水瓶、时装手绘稿和杂志精心绘就的原创插画。六位英国出生的插画家亦将应邀在此次展览中展示画作,Gruau与Dior迪奥品牌的无间合作正是他们的灵感源泉。

  9. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Chris

    2010-01-01

    <正>01至真"纸"美>美国时装真人秀节目《Project Runway》在最近的一期节目里,请参赛者们用牛皮纸来代替寻常的布料,做出属于自己的牛皮纸时装,结果平时表现平平的参赛者都发挥得不错。原因何在?牛皮纸那朴实无华,却坚韧有型的特色赋予了"材料"更多的可塑性,同时也呼应了当下全球大热的

  10. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Chris

    2010-01-01

    <正>01DNA科技注入睫毛膏>在护肤品中添加生物基因技术,已不再是什么大新闻。但你听说过,在睫毛膏里也加入这一科技吗?7月即将问市的Lancome全新梦魅臻采睫毛膏,就以兰蔻高科技研究成果为基础,加入了独一无二的基因配比技术,用以启动睫毛干细胞的活性,促进干细胞新生,仿佛为睫毛注入第二次生命般,让睫毛变长变密。同时,特别研制的刷头,可以更好的让膏体和睫毛接触,达到更完美的浓睫艳眸效果。www.lancome.com

  11. Beauty

    Institute of Scientific and Technical Information of China (English)

    Jasmine; Chris

    2010-01-01

    <正>01沪上定制妆容〉香奈儿巴黎——上海高级手工坊将时尚大帝Karl Lagerfeld和彩妆大师Peter Philips都带来了上海,除了为上海度身定做的华服之外,那颇有东方韵味的妆容也令人印象深刻。Peter在采访中透露这次妆面的灵感来自Karl给他看的一部电影——《花样年华》。模特们的妆容需要看上去既要有像张曼玉穿旗袍时的优雅,又能表现出如未来女战士般的魄力。正如服装秀一开场,模特们所穿着服装的灵

  12. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Paris; Sun

    2011-01-01

    <正>01Aesop来自澳洲的"伊索寓言">"伊索寓言"在巴黎上演,Aesop巴黎店最新橱窗展,伊索灵魂漫游于方寸橱窗间。成立于1987年的澳洲品牌伊索(Aesop),在纯天然植物护肤的基础上率先推行有机理念,并结合内外调理的"理智"生活哲学。出身于拥有最多濒临绝种的奇花异草、珍禽怪兽的澳大利亚净土,品牌从研发、测试到

  13. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Jasmine; Chris

    2010-01-01

    <正>022010 Chanel春夏高级成衣发布会后台彩妆探秘在这场仿佛是法国皇后Marie Antoinette在凡尔赛宫的小农庄重现的时装秀上,除了精致奢华的新款时装令人眼前一亮之外,彩妆创意总监Peter Phillips在妆容上也为我们带来了新一年的流行趋势,那就是以高雅别致的米色调为主,打造令人耳目一新、清新富有朝气的妆容。这种邻家女孩味十足的妆容效果,基本适合所有的女性,所有的场合。如果你嫌妆容过于"平淡",那

  14. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie Kwok

    2012-01-01

    <正>01好莱坞巨星的活肤秘诀>由匈牙利皮肤科医生Dr.Laszlo创办的纽约品牌Emo Laszlo,一直深受皇室名人及好莱坞巨星的喜爱,今年是Emo Laszlo创立八十五周年,特别以五位家喻户晓的好莱坞女星为灵感,推出八十五周年限量版好莱坞尊贵系列。五款尊贵系列的原装产品分别为珍珠亮采唤肤啫喱、魅惑水润修护眼霜、Refresh尊贵宝石再生补湿霜、搪瓷肌抗氧化修护霜及丝滑

  15. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Jasmine; Chris

    2009-01-01

    <正>01寻找秋冬发型灵感>Aveda刚发表了新一季发型及发色潮流造型照,品牌的环球创作总监Antoinette Beenders介绍这系列灵感启发自80年代的歌德式华丽,他说:"今季的造型设计大量运用了复古味极浓的经典剪裁和发色。"一如以往,Aveda的造型设计无论是发型及发色都相当实用,参考价值甚高,想改变造型又没有头绪的话,可到品牌的网址找找合心意的发色与发型,更有来自世界各地的造型师所提供的理发建议。除此之外,可留意这辑造型照的另一个特别之处:模特儿所穿的礼服,全采用可循环再用的物料制造,如旧报纸、旧牛仔布料及风衣等,重新解构再造,非常合乎Aveda的环保原则。

  16. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Kidd; Ji; Paris; Sun

    2011-01-01

    <正>01一片蓝心向北非Giorgio Armani用一种颜色完成了2011春夏女装秀,撒哈拉沙漠中部游牧民族图阿雷格人的文化就是其女装的灵感来源。而品牌彩妆的特质在于其质感和色彩都基于时装的灵感、布料的材质之上。2011年春夏妆容,其灵感同样延续来自图阿雷格人面纱的颜色——靛蓝。设计师Giorgio Armani认为:"蓝与黑的搭配会让经典的黑色更有生命力。"通过对蓝色和黑色搭配的重新诠释,赋予了品牌招牌式优雅更富故事性与情境感的篇章。

  17. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie; Kwok

    2011-01-01

    <正>01植村秀东京眼妆美学〉植村秀这彩妆品牌相信是不少潮流达人的心头好,不只因为其一流品质,更因为品牌从来以"不停构思改进与发掘"为哲学,不断推陈出新。今季炎夏,配合自由配搭彩妆盒,及全新系列眼影色系,品牌打造个人独特的彩妆盒。彩妆盒由日本著名建筑师干久美子设计,简洁优雅之余,亦令彩妆盒不需使用任何黏贴工具,亦能轻松替换眼影及胭脂组合。

  18. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Chris

    2010-01-01

    <正>01帝王之水典藏版华丽开售>现在你不必亲身飞到巴黎或香港等地,Guerlain巴黎之家专属限量香氛上海梅龙镇伊势丹精品专柜店将在7月隆重揭幕。作为国内唯一一家精品店,也是香榭丽舍大道68号LaMaison Guerlain娇兰之家的华丽缩影,在此你可以独家购买到帝王之水金箔蜂姿琉金典藏版等多款限量版香水。帝王之水乃品牌创始人Pierre Francois Pascal为法国Eugenie皇后特别制作的新婚礼物,清新、芬芳而怡神的它,是橙花、香橼、柠檬、

  19. Beauty

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

    <正>眉:自然生态眉首先要扭转精致、服帖、细长才是完美眉形的观念。选择比发色淡一度的眉粉自下眉头处1cm处为起点,向眉峰轻扫,进而顺延至眉尾,别忘记用余粉将眉毛边缘处做好过渡。最后用眉形修饰膏以先顺再逆的方向梳理眉毛,缔造根根分明的印象。眼:亚洲人的内陷式双眼皮,令彩色眼线往往不足以提升眼晴的精气神。双色眼线以深色在靠近内眼睑的位置铺底,此处精细和轻巧的眼尾上挑是关键,然后用明媚的彩色眼线以略宽出1~2cm的方式勾勒,霎时拥有明眸点睛的魅惑力。

  20. Beauty

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    一年之中,可以好好重整肌肤状况的有两个时段,分别是3,4月和10,11月,这两个时节,肌肤刚从剧烈的换季变化中回复平稳,最适合趁机除去累积的废物,并补充肌肤所需的营养,就像大病之后需要恢复元气一样。

  1. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    <正> 今年起,说到最有效的抗氧化成分,你脑中该留下一个新名词"IDEBENONE 艾地苯"。这种由 ELIZABETH ARDEN 携手 BOTOX 肉毒杆菌素的创造者——ALLERGAN 联手推出的新成分已被运用在"PREVAGE 逆时橘灿精纯凝露"中,掀起了全球医学美容热潮。被称为"抗氧化超人"的它在18岁后即可每天使用,对抗光老化及预防皱纹。

  2. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    2014-01-01

    <正>眼部的流线美学2014秋冬的T台妆容,醒目又流畅的眼妆深入人心,能够一根根修饰睫毛的睫毛刷,触感光滑柔软的丝绒效果眼影,勾勒夸张猫眼效果的厚泽眼线,所有的产品都重在打造自然流畅中可扩大眼形的清秀眼妆。01细致巧妙地提亮肌肤疲惫黯淡区域圣罗兰明彩笔1#2.5ml/RMB36002柔滑质感与千变万化的妆效圣罗兰臻彩四色眼影5#5g/RMB56003惊艳系列,打造含情脉脉的眼神迪奥单色眼影3g/RMB31004打造诱惑双眸的波普粉色迪奥魅惑睫毛膏9ml/RMB36005精致珍珠母贝令双眸晶莹闪亮希恩黎植物炫彩眼影06极其柔软,幼滑的眼线笔希思黎植物丝缎眼线笔

  3. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie; Kwok

    2011-01-01

    <正>01闪耀细胞思维论〉Cle de Peau Beaute认为每一个皮肤细胞,犹如脑细胞一样,能够自我思考。它们均具有处理各种情报的能力,只要有效管理细胞使之接收更多正面讯息,阻截负面情报,提升肌肤本身的机制优化细胞机能,便能诱导更多正面讯息能量的吸收,从而改善皮肤质量。而全新Basic Care系列,便是因应闪耀细胞管理而研发。

  4. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie; Kwok

    2011-01-01

    <正>01Burberry Body全新香氛>Burberry Body找来英国女演员兼模特儿Rosie Huntington-Whiteley,让她成为品牌的第一位代言人,从她身上完美地体现出感性、自信和谦逊的平衡。全新香氛使用的成分亦不简单,除了以天然玫瑰精油和香草为基调外,前调的苦艾酒曾一度是欧洲禁酒,也是梵高每次画画必喝的最爱。品牌还在香水瓶上花了不少心思,品牌刨作总监Christopher Bailey表示:"我常将

  5. Beauty

    Institute of Scientific and Technical Information of China (English)

    Katie Kwok

    2012-01-01

    <正>01澳大利亚有机美发>澳大利亚天然资源丰富,所以不少美容品牌都从当地的有机农庄获取原材料,主要因为有机草本成分内含的维他命、矿物质等营养成分比非有机草本植物高,同时有助减少吸收不必要的抗生素、农药等化学成分,令消费者更安心使用。澳洲进口品牌australian organics,在澳洲拥有十五年历史,产品包括面部护理、沐浴及身体护理以及头发护理系列。其有机成分获澳洲国家可持续农业协会机构(NASAA)认可,并属澳洲低碳产品商认可成员,全部产品均于澳洲制造,绝对不含石化成分、人造香料、色素及任何基因改造和动物测试,成分温和,容易吸收,特别适合亚洲人肌肤。品牌根据不同发质及肌肤需要,以天然草本成分调配不同配方外,亦以舒缓、减压、安抚情绪、助眠等有机香熏精华调配而成,让秀发及头部皮肤获得细致呵护之余,于感官上也同时得到洗涤,令日常护理程序变得更轻松。

  6. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie Kwok

    2012-01-01

    <正>01蜗牛美容秘辛〉早于1980年,智利皮肤科医生Mr.Fernando Bascunan就已发现蜗牛分泌物具有非凡的护肤功效。当时他的家族以养殖蜗牛为生,并出口至欧洲各国成为美食。多年来在处理蜗牛的过程中,Fernando Bascunan意外地发现,工人被工具刮伤的患处不但没有发炎伤口愈合会更快,也不会留下疤痕。自此以后,他就开始对蜗牛进行研究,发现蜗牛黏液可在人类皮肤上产生嫩肤、再生及修复的神奇功效。近年来不少美容品牌都开始投放资源,研发蜗牛黏液护肤品,其中来自韩国的MISSHA,以韩国锦

  7. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Kidd Ji

    2010-01-01

    <正>01Chanel 2010 Couture Makeup在高级订制服的秀场上,时装及配饰不但影响着未来一至两季的服装潮流,模特的妆容作为整个系列的点睛之笔,也对妆容的流行指明方向。由Chanel全球彩妆创意总监Peter Philips为秋冬高级订制系列创作的红色概念妆容就是其中一个例子。Peter Philips表示,他的设计概念来自Karl Lagerfeld向他展示的设计草图:"我发现他在所有的模特嘴上都加上了一抹红色。而他展示给我看的第一件外套也是红色

  8. Beauty

    Institute of Scientific and Technical Information of China (English)

    James; Stephen; Behrens; 王海强

    2006-01-01

    古往今来,人们一直通过语言、艺术或思考来探究人生的真谛。有人以追求人生的真理为乐,甚至是舍生取义;也有人在追求真理的过程中不断完善自己的生命。本文以朴实的文笔娓娓述说了一个令人深思而嗟叹的故事。故事女主人公相貌丑陋,但却以她独特的灵气、细腻的美感、动人的话语征服了人心。她对待人生的态度和生活的勇气,无疑会令所有的身体健康者汗颜!

  9. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie; Kwok

    2011-01-01

    <正>01台湾有机>说起护肤品的出产地,瑞士美国等欧美传统美容王国当然占市场大部分位置,但有时候因气候水土不同,在美国用起来一流的产品,来到亚洲可能就要大打折扣。近年除了韩国,台湾出产的美容护肤产品亦大受欢迎,除了一流的质量外,价位亦十分相宜。以统欣生物科技公司旗下品牌之一Deary媞尔妮为例,在身体及脸部保养品领域开发专研,以有机草本原料,配合独特研发技术,其面膜销售更是台湾连锁便利店排行第一。统欣生物科技公司,除了研发有效的护肤品之余,亦对护

  10. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Kidd Ji

    2010-01-01

    <正>01悦木之源"眼咖啡">一直以为,累了、困了只要一杯咖啡就能提神解乏。却没想到,咖啡的活力还能喂进眼睛里,仿佛永远没有睡醒的倦怠双眼,在遇见悦木之源人参活力焕亮眼霜之后便能苏醒。这款在业界素有"精神眼霜"、"眼咖啡"、"加班眼霜"等众多俏皮昵称的Origins GinzingTM人参活力焕亮眼霜优选两款醒神植物能量——"百草之王"人参与"醒神之王"咖啡,同时融汇了冬虫夏草、木兰花、锦紫苏、橙皮苷、黄芩、绿茶等多种活力秘方,能够有效针对改善黑眼圈、眼部浮肿和眼疲劳等眼部问题,仿佛给倦眼来一杯Espresso。

  11. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Chris

    2010-01-01

    <正>01Christian Dior贵族淑女踏春归来随着马蹄声的配乐响起,Christian Dior宣布贵族淑女的时代回归。绣花、珍珠、花朵这些春意盎然的细节都运用到了薄纱以及各种轻盈的材质上。马鞭与马靴还有骑马的高帽搭配着长裙,优雅帅气的骑士装扮瞬间抓住了在场女士们的心。在妆容上,化妆师

  12. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie Kwok

    2012-01-01

    <正>01摩诃之美>摩诃本为梵文,在佛教中有超越有情与无情,在无边无际、有形与无形之间显得圆通神妙用的意思。正如Cle de PeauBeaute秋冬妆容系列,以光亮色彩从黑暗中反映出来,以阴影映衬着明亮的双眸,以光泽衬托出不一样的色彩。品牌的彩妆美容形象师Lucia Pieroni说:"色彩在黑暗中绽亮生辉,令眼影细滑如丝。炯炯有神的明眸,在色彩与质感交织下美丽迷人,映照神秘的黑夜。"而系列最新三款让人惊艳的眼影色调,以散发不同光芒的珠光组合塑造聚光焦点,色彩中若隐若现的光泽,在瞳孔中映照出神秘光芒,演绎高贵优雅的魅力。色调可随意混配,

  13. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Kidd; Ji; Paris; Sun

    2011-01-01

    <正>01纸艺幻发纸艺能成为备受关注的艺术形态,是因为纸本身拥有轻盈及可塑性强的特质,再配合极富想象力的创作,即能呈现出千变万化的视觉形象,承载无限艺术价值。沙宣认为头发与纸艺的创作概念如出一辙,今年冬季亦从纸艺中汲取灵感,设计出了轻盈、可塑的概念发型。以"逆重幻觉"为名的发型特辑借用纸艺"挣脱重力的束缚仿佛能够对抗万有引力的存在"这一概念,丰盈的发型在充满空气感的同时,造型上也十分具有纸张所带来的结构感。当被问及如何打造这样的发型时,其创意总监回答:"关键在于拥有轻盈可塑的健康秀发。"道理虽不难,达到却不易。

  14. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie Kwok

    2012-01-01

    <正>01世界海洋大同>La Mer的世界海洋日活动,不仅要提升大家对海洋美态和修复力量的关注,更要呼吁人们对它脆弱的生态多加爱惜。La Mer相信海洋植物如太平洋海藻,其惊人力量尚未被完全发掘及理解,所以我们应全力支持生态保育,为下一代守护并保存这大自然的瑰宝。今年的世界海洋日活动鼓励大众探索、发掘和欣赏海洋宝库。La Mer特别设计了一百毫升的世界海洋日Creme de la Mer限量版面霜,瓶身设计的灵感亦撷取

  15. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie Kwok

    2012-01-01

    <正>01意大利大家闺秀>Valentino除了经典的火红女郎形象外,近年时装秀的蕾丝都充分表现出品牌对女性妩媚的诠释。而今次Valentino的首支吞氛更是为其女性时装及生活方式所启发。为了这支香氛像是一束综合了多种鲜花精炼而成的香味,选用的材料都极度女性化,充分代表了Valentino女性的独特气质,因此便以Valentina命名。品牌邀两位杰出的调香师:Oliver Cresp

  16. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie; Kwok

    2011-01-01

    <正>01抗敏医美学>据说橄榄树非常长寿,可以健康地存活1000年,所以科学家相信橄榄树含有保持青春的成分,知名的皮肤科医生及抗衰老专家Nicholas Perricone博士研发的Perricone MD护肤品牌,就是以橄榄叶及其果实的天然分子橄榄多酚为敏感肌肤带来有效护理的抗衰老系列。

  17. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie Kwok

    2012-01-01

    <正>01救生员认可的有机防晒美国生态环境研究专家Chris Birchby的家人,不幸患上黑色素瘤,令他明白防晒的重要,同时作为生态环境研究专家,他亦希望护肤品不会加重地球的负担,所以研发出防晒品牌COOLA,以有机天然成分为主,同时以物理性及化学性的防晒配方,推出高效的防晒产品,除了获得各个有机认证外,亦获得美国救生员协会的认可。

  18. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Paris; Sun

    2011-01-01

    <正>01美妆拜占庭拜占庭艺术(Byzantine art)指东罗马帝国的艺术。大体来说,所有拜占庭的艺术都充满了精神的象征主义。重视心象,不容有写实主义的存在。为配合Chanel巴黎一拜占庭高级手工坊系列成衣发布,Chanel全球彩妆创意总监彼德·菲利浦斯以世界知名的狄奥多拉女皇Theodora的马赛克肖像图为灵感创作了一组妆容,而肖像图中女皇眉峰部分所描绘的红色眼影线条,被他用作了这次妆

  19. Generalized functions, convergence structures, and their applications

    CERN Document Server

    Pap, Endre; Pilipović, Stevan; Vladimirov, Vasilij; International Conference "Generalized functions, convergence structures and their applications" (GFCA-87)

    1988-01-01

    This Proceedings consists of a collection of papers presented at the International Conference "Generalized functions, convergence structures and their applications" held from June 23-27, 1987 in Dubrovnik, Yugoslavia (GFCA-87): 71 participants from 21 countr~es from allover the world took part in the Conference. Proceedings reflects the work of the Conference. Plenary lectures of J. Burzyk, J. F. Colombeau, W. Gahler, H. Keiter, H. Komatsu, B. Stankovic, H. G. Tillman, V. S. Vladimirov provide an up-to-date account of the cur­ rent state of the subject. All these lectures, except H. G. Tillman's, are published in this volume. The published communications give the contemporary problems and achievements in the theory of generalized functions, in the theory of convergence structures and in their applications, specially in the theory of partial differential equations and in the mathematical physics. New approaches to the theory of generalized functions are presented, moti­ vated by concrete problems of applicat...

  20. Protein tyrosine phosphatases: structure-function relationships.

    Science.gov (United States)

    Tabernero, Lydia; Aricescu, A Radu; Jones, E Yvonne; Szedlacsek, Stefan E

    2008-03-01

    Structural analysis of protein tyrosine phosphatases (PTPs) has expanded considerably in the last several years, producing more than 200 structures in this class of enzymes (from 35 different proteins and their complexes with ligands). The small-medium size of the catalytic domain of approximately 280 residues plus a very compact fold makes it amenable to cloning and overexpression in bacterial systems thus facilitating crystallographic analysis. The low molecular weight PTPs being even smaller, approximately 150 residues, are also perfect targets for NMR analysis. The availability of different structures and complexes of PTPs with substrates and inhibitors has provided a wealth of information with profound effects in the way we understand their biological functions. Developments in mammalian expression technology recently led to the first crystal structure of a receptor-like PTP extracellular region. Altogether, the PTP structural work significantly advanced our knowledge regarding the architecture, regulation and substrate specificity of these enzymes. In this review, we compile the most prominent structural traits that characterize PTPs and their complexes with ligands. We discuss how the data can be used to design further functional experiments and as a basis for drug design given that many PTPs are now considered strategic therapeutic targets for human diseases such as diabetes and cancer.

  1. Measurement of charm and beauty-production in deep inelastic scattering at HERA and test beam studies of ATLAS pixel sensors

    Energy Technology Data Exchange (ETDEWEB)

    Libov, Vladyslav

    2013-08-15

    A measurement of charm and beauty production in Deep Inelastic Scattering at HERA is presented. The analysis is based on the data sample collected by the ZEUS detector in the period from 2003 to 2007 corresponding to an integrated luminosity of 354 pb{sup -1}. The kinematic region of the measurement is given by 5beauty quarks. Secondary vertices due to decays of charm and beauty hadrons are reconstructed, in association with jets. The jet kinematics is defined by E{sup jet}{sub T}>4.2(5) GeV for charm (beauty) and -1.6<{eta}{sup jet}<2.2 for both charm and beauty, where E{sup jet}{sub T} and {eta}{sup jet} are the transverse energy and pseudorapidity of the jet, respectively. The significance of the decay length and the invariant mass of charged tracks associated with the secondary vertex are used as discriminating variables to distinguish between signal and background. Differential cross sections of jet production in charm and beauty events as a function of Q{sup 2}, y, E{sup jet}{sub T} and {eta}{sup jet} are measured. Results are compared to Next-to-Leading Order (NLO) predictions from Quantum Chromodynamics (QCD) in the fixed flavour number scheme. Good agreement between data and theory is observed. Contributions of the charm and beauty production to the inclusive proton structure function, F{sup cbar} {sup c}{sub 2} and F{sup b} {sup anti} {sup b}{sub 2}, are determined by extrapolating the double differential cross sections using NLO QCD predictions. Contributions to the test beam program for the Insertable B-Layer upgrade project of the ATLAS pixel detector are discussed. The test beam data analysis software package EUTelescope was extended, which allowed an efficient analysis of ATLAS pixel sensors. The USBPix DAQ system was integrated into the EUDET telescope allowing test beam

  2. Nuclear Structure Functions from Constituent Quark Model

    CERN Document Server

    Arash, F; Arash, Firooz; Atashbar-Tehrani, Shahin

    1999-01-01

    We have used the notion of the constituent quark model of nucleon, where a constituent quark carries its own internal structure, and applied it to determine nuclear structure functions ratios. It is found that the description of experimental data require the inclusion of strong shadowing effect for $x<0.01$. Using the idea of vector meson dominance model and other ingredients this effect is calculated in the context of the constituent quark model. It is rather striking that the constituent quark model, used here, gives a good account of the data for a wide range of atomic mass number from A=4 to A=204.

  3. Changing perceptions of beauty: a surgeon's perspective.

    Science.gov (United States)

    Adamson, Peter A; Zavod, Matthew B

    2006-08-01

    Beauty is a mystery that has been with us for ages. Scholars and scientists have investigated its roots and effects, and its presence is ubiquitous. Has the construct of beauty changed over time? Is our sense of beauty learned or innate? What IS beauty, and can we quantify it? A substantial amount of work supports a Darwinian theory of selection, which predicts a survival advantage based on physical attractiveness. However, there is evidence that certain perceptions of beauty change with time. Indeed, the recent globalization of modern society has wrought changes in our perceptions of beauty. Are patients electing cosmetic surgery procuring a survival advantage, or are they bypassing genetics and setting a new standard for beauty? As facial plastic surgeons, we must be poised to respond to this metamorphosis and understand its roots. Although there is some equivocation and debate about this elusive subject, it is our duty to stay abreast of the current dynamic to make sound judgments that are in the best interests of our patients.

  4. Regulated complex assembly safeguards the fidelity of Sleeping Beauty transposition

    Science.gov (United States)

    Wang, Yongming; Pryputniewicz-Dobrinska, Diana; Nagy, Enikö Éva; Kaufman, Christopher D.; Singh, Manvendra; Yant, Steve; Wang, Jichang; Dalda, Anna; Kay, Mark A.; Ivics, Zoltán; Izsvák, Zsuzsanna

    2017-01-01

    The functional relevance of the inverted repeat structure (IR/DR) in a subgroup of the Tc1/mariner superfamily of transposons has been enigmatic. In contrast to mariner transposition, where a topological filter suppresses single-ended reactions, the IR/DR orchestrates a regulatory mechanism to enforce synapsis of the transposon ends before cleavage by the transposase occurs. This ordered assembly process shepherds primary transposase binding to the inner 12DRs (where cleavage does not occur), followed by capture of the 12DR of the other transposon end. This extra layer of regulation suppresses aberrant, potentially genotoxic recombination activities, and the mobilization of internally deleted copies in the IR/DR subgroup, including Sleeping Beauty (SB). In contrast, internally deleted sequences (MITEs) are preferred substrates of mariner transposition, and this process is associated with the emergence of Hsmar1-derived miRNA genes in the human genome. Translating IR/DR regulation to in vitro evolution yielded an SB transposon version with optimized substrate recognition (pT4). The ends of SB transposons excised by a K248A excision+/integration- transposase variant are processed by hairpin resolution, representing a link between phylogenetically, and mechanistically different recombination reactions, such as V(D)J recombination and transposition. Such variants generated by random mutation might stabilize transposon-host interactions or prepare the transposon for a horizontal transfer. PMID:27913727

  5. Regulated complex assembly safeguards the fidelity of Sleeping Beauty transposition.

    Science.gov (United States)

    Wang, Yongming; Pryputniewicz-Dobrinska, Diana; Nagy, Enikö Éva; Kaufman, Christopher D; Singh, Manvendra; Yant, Steve; Wang, Jichang; Dalda, Anna; Kay, Mark A; Ivics, Zoltán; Izsvák, Zsuzsanna

    2017-01-09

    The functional relevance of the inverted repeat structure (IR/DR) in a subgroup of the Tc1/mariner superfamily of transposons has been enigmatic. In contrast to mariner transposition, where a topological filter suppresses single-ended reactions, the IR/DR orchestrates a regulatory mechanism to enforce synapsis of the transposon ends before cleavage by the transposase occurs. This ordered assembly process shepherds primary transposase binding to the inner 12DRs (where cleavage does not occur), followed by capture of the 12DR of the other transposon end. This extra layer of regulation suppresses aberrant, potentially genotoxic recombination activities, and the mobilization of internally deleted copies in the IR/DR subgroup, including Sleeping Beauty (SB). In contrast, internally deleted sequences (MITEs) are preferred substrates of mariner transposition, and this process is associated with the emergence of Hsmar1-derived miRNA genes in the human genome. Translating IR/DR regulation to in vitro evolution yielded an SB transposon version with optimized substrate recognition (pT4). The ends of SB transposons excised by a K248A excision(+)/integration(-) transposase variant are processed by hairpin resolution, representing a link between phylogenetically, and mechanistically different recombination reactions, such as V(D)J recombination and transposition. Such variants generated by random mutation might stabilize transposon-host interactions or prepare the transposon for a horizontal transfer.

  6. Exhibition - Mathematics, A Beautiful Elsewhere

    CERN Multimedia

    2011-01-01

    From 21 October 2011 to 18 March 2012, the Fondation Cartier pour l’art contemporain will present the exhibition Mathematics: A Beautiful Elsewhere, an exhibition developed in association with the Institut des Hautes Études Scientifiques (IHÉS) and under the patronage of UNESCO. For this unprecedented event, the foundation invited mathematicians to work with artists with whom it has previously worked to create an exhibition that allows visitors to see, hear, do, interpret and think about mathematics. By bringing mathematics into its premises, the Fondation Cartier is itself undergoing the “sudden change of scenery” described by mathematician Alexandre Grothendieck. More information is available here. Fondation Cartier pour l’art contemporain 261, boulevard Raspail 75014 Paris http://fondation.cartier.com Private Visit For professors, researchers and all the staff of Mathematics departments...

  7. Longitudinal Structure Function FL from Charm Structure Function F2c

    Institute of Scientific and Technical Information of China (English)

    B.Rezaei; G.R.Boroun

    2013-01-01

    We predict the effect of the charm structure function on the longitudinal structure function at small x.In NLO analysis we find that the hard Pomeron behavior gives a good description of FL and Fkc (k =2,L) at small x values.We conclude that a direct relation between FL∝ F2c would provide useful information on how to measure longitudinal structure function at high Q2 values.Having checked that this model gives a good description of the data,when compared with other models.

  8. Proteins with Novel Structure, Function and Dynamics

    Science.gov (United States)

    Pohorille, Andrew

    2014-01-01

    Recently, a small enzyme that ligates two RNA fragments with the rate of 10(exp 6) above background was evolved in vitro (Seelig and Szostak, Nature 448:828-831, 2007). This enzyme does not resemble any contemporary protein (Chao et al., Nature Chem. Biol. 9:81-83, 2013). It consists of a dynamic, catalytic loop, a small, rigid core containing two zinc ions coordinated by neighboring amino acids, and two highly flexible tails that might be unimportant for protein function. In contrast to other proteins, this enzyme does not contain ordered secondary structure elements, such as alpha-helix or beta-sheet. The loop is kept together by just two interactions of a charged residue and a histidine with a zinc ion, which they coordinate on the opposite side of the loop. Such structure appears to be very fragile. Surprisingly, computer simulations indicate otherwise. As the coordinating, charged residue is mutated to alanine, another, nearby charged residue takes its place, thus keeping the structure nearly intact. If this residue is also substituted by alanine a salt bridge involving two other, charged residues on the opposite sides of the loop keeps the loop in place. These adjustments are facilitated by high flexibility of the protein. Computational predictions have been confirmed experimentally, as both mutants retain full activity and overall structure. These results challenge our notions about what is required for protein activity and about the relationship between protein dynamics, stability and robustness. We hypothesize that small, highly dynamic proteins could be both active and fault tolerant in ways that many other proteins are not, i.e. they can adjust to retain their structure and activity even if subjected to mutations in structurally critical regions. This opens the doors for designing proteins with novel functions, structures and dynamics that have not been yet considered.

  9. Characterizing Molecular Structure by Combining Experimental Measurements with Density Functional Theory Computations

    Science.gov (United States)

    Lopez-Encarnacion, Juan M.

    2016-06-01

    In this talk, the power and synergy of combining experimental measurements with density functional theory computations as a single tool to unambiguously characterize the molecular structure of complex atomic systems is shown. Here, we bring three beautiful cases where the interaction between the experiment and theory is in very good agreement for both finite and extended systems: 1) Characterizing Metal Coordination Environments in Porous Organic Polymers: A Joint Density Functional Theory and Experimental Infrared Spectroscopy Study 2) Characterization of Rhenium Compounds Obtained by Electrochemical Synthesis After Aging Process and 3) Infrared Study of H(D)2 + Co4+ Chemical Reaction: Characterizing Molecular Structures. J.M. López-Encarnación, K.K. Tanabe, M.J.A. Johnson, J. Jellinek, Chemistry-A European Journal 19 (41), 13646-13651 A. Vargas-Uscategui, E. Mosquera, J.M. López-Encarnación, B. Chornik, R. S. Katiyar, L. Cifuentes, Journal of Solid State Chemistry 220, 17-21

  10. Phosphatidylinositol 4-kinases: Function, structure, and inhibition

    Energy Technology Data Exchange (ETDEWEB)

    Boura, Evzen, E-mail: boura@uochb.cas.cz; Nencka, Radim, E-mail: nencka@uochb.cas.cz

    2015-10-01

    The phosphatidylinositol 4-kinases (PI4Ks) synthesize phosphatidylinositol 4-phosphate (PI4P), a key member of the phosphoinositide family. PI4P defines the membranes of Golgi and trans-Golgi network (TGN) and regulates trafficking to and from the Golgi. Humans have two type II PI4Ks (α and β) and two type III enzymes (α and β). Recently, the crystal structures were solved for both type II and type III kinase revealing atomic details of their function. Importantly, the type III PI4Ks are hijacked by +RNA viruses to create so-called membranous web, an extensively phosphorylated and modified membrane system dedicated to their replication. Therefore, selective and potent inhibitors of PI4Ks have been developed as potential antiviral agents. Here we focus on the structure and function of PI4Ks and their potential in human medicine.

  11. Multimodality imaging of structure and function

    Energy Technology Data Exchange (ETDEWEB)

    Townsend, D W [Departments of Medicine and Radiology, University of Tennessee Medical Center, 1924 Alcoa Highway, Knoxville, TN 37920 (United States)], E-mail: dtownsend@mc.utmck.edu

    2008-02-21

    Historically, medical devices to image either anatomical structure or functional processes have developed along somewhat independent paths. The recognition that combining images from different modalities can nevertheless offer significant diagnostic advantages gave rise to sophisticated software techniques to coregister structure and function. Recently, alternatives to retrospective software-based fusion have become available through instrumentation that combines two imaging modalities within a single device, an approach that has since been termed hardware fusion. As a result, following their recent introduction into the clinic, combined PET/CT and SPECT/CT devices are now playing an increasingly important role in the diagnosis and staging of human disease. Recently, although limited to the brain, the first clinical MR scanner with a PET insert, a technically-challenging design, has been undergoing evaluation. This review will follow the development of multimodality instrumentation for clinical use from conception to present-day technology and assess the status and future potential for such devices. (topical review)

  12. Bathing in Reeking Wounds: The Liberal Arts, Beauty, and War

    Science.gov (United States)

    Stimpson, Catharine R.

    2014-01-01

    A historic dialectic exists between the beautiful and the bestial. The bestial destroys the beautiful, but in a bloody miracle, the beautiful emerges from the womb of the bestial, the "terrible beauty" of which the poet W. B. Yeats wrote. The liberal arts, so often thought to dwell in a remote ivory tower, embody this dialectic. Wars and…

  13. A study of the prevalence of respiratory morbidity and ventilatory obstruction in beauty parlour workers

    Directory of Open Access Journals (Sweden)

    Kesavachandran C

    2006-01-01

    Full Text Available A study was conducted in beauty parlor workers of Lucknow, India, to assess the prevalence of respiratory morbidity and lung function abnormalities compared to their control subjects belonging to the same socioeconomic status and ethnic group, having never been exposed to the workplace of beauty parlor and having not used any cosmetics. Respiratory morbidity and bronchial obstruction based on PEFR study was conducted in 196 beauty parlor workers and 35 control subjects. All the participants were non-smokers and were matched for age, height, weight and socioeconomic status. Peak expiratory flow rate were performed using Peak Flow meter. Symptomatic workers showed bronchial obstruction (28%, and this prevalence was significantly higher ( P P < 0.01 than male workers (1.42. Overall respiratory morbidity among beauty parlor workers showed higher (12.7% when compared with control group (2.8% but differences couldn′t attain any significance. Although nonsignificant, workers in beauty parlor showed more prevalence (9.4% of bronchial obstruction based on PEFR than controls (4%. This study showed that beauty parlor workers were more prone to respiratory morbidity and lung function abnormalities, as the study group selected were non-smokers.

  14. Structure and function of mammalian cilia

    DEFF Research Database (Denmark)

    Satir, Peter; Christensen, Søren T

    2008-01-01

    In the past half century, beginning with electron microscopic studies of 9 + 2 motile and 9 + 0 primary cilia, novel insights have been obtained regarding the structure and function of mammalian cilia. All cilia can now be viewed as sensory cellular antennae that coordinate a large number...... of cellular signaling pathways, sometimes coupling the signaling to ciliary motility or alternatively to cell division and differentiation. This view has had unanticipated consequences for our understanding of developmental processes and human disease....

  15. General Structures of Block Based Interpolational Function

    Institute of Scientific and Technical Information of China (English)

    ZOU LE; TANG SHUO; Ma Fu-ming

    2012-01-01

    We construct general structures of one and two variable interpolation function,without depending on the existence of divided difference or inverse differences,and we also discuss the block based osculatory interpolation in one variable case.Clearly,our method offers many flexible interpolation schemes for choices.Error terms for the interpolation are determined and numerical examples are given to show the effectiveness of the results.

  16. Truncated Moment Analysis of Nucleon Structure Functions

    Energy Technology Data Exchange (ETDEWEB)

    A. Psaker; W. Melnitchouk; M. E. Christy; C. E. Keppel

    2007-11-16

    We employ a novel new approach using "truncated" moments, or integrals of structure functions over restricted regions of x, to study local quark-hadron duality, and the degree to which individual resonance regions are dominated by leading twists. Because truncated moments obey the same Q^2 evolution equations as the leading twist parton distributions, this approach makes possible for the first time a description of resonance region data and the phenomenon of quark-hadron duality directly from QCD.

  17. Anisotropic nanomaterials: structure, growth, assembly, and functions

    OpenAIRE

    Panikkanvalappil R. Sajanlal; Theruvakkattil S. Sreeprasad; Samal, Akshaya K.; Thalappil Pradeep

    2011-01-01

    Comprehensive knowledge over the shape of nanomaterials is a critical factor in designing devices with desired functions. Due to this reason, systematic efforts have been made to synthesize materials of diverse shape in the nanoscale regime. Anisotropic nanomaterials are a class of materials in which their properties are direction-dependent and more than one structural parameter is needed to describe them. Their unique and fine-tuned physical and chemical properties make them ideal candidates...

  18. Recognition and Description of Music and Beauty

    OpenAIRE

    矢向, 正人

    2011-01-01

    What is difficult with any discussion on music is that it cannot be objectively determined whether or not the music in question is a matter of beauty. On the other hand, we know that in the world there are some cultural areas where beauty is not known in connection with music. In this essay by introducing into play Wittgenstein's idea of "language game," the author proposes a theoretical model to recognize variouis kinds of musical beauty. According to the latter Wittgenstein, what is support...

  19. Pig transgenesis by Sleeping Beauty DNA transposition

    DEFF Research Database (Denmark)

    Jakobsen, Jannik E.; Li, Juan; Kragh, Peter M.

    2011-01-01

    disease models. In this report, we present transgenic pigs created by Sleeping Beauty DNA transposition in primary porcine fibroblasts in combination with somatic cell nuclear transfer by handmade cloning. Göttingen minipigs expressing green fluorescent protein are produced by transgenesis with DNA...... plasmid DNA. Our findings illustrate critical issues related to DNA transposon-directed transgenesis, including coincidental plasmid insertion and relatively low Sleeping Beauty transposition activity in porcine fibroblasts, but also provide a platform for future development of porcine disease models...... using the Sleeping Beauty gene insertion technology....

  20. Returns to beauty over the life course

    DEFF Research Database (Denmark)

    Jæger, Mads Meier

    This paper analyzes returns to facial beauty over the life course with respect to four outcomes: Socioeconomic status (SES), marital success, spouse’s SES, and health. I use data from the Wisconsin Longitudinal Study which, based on high school yearbook photos, has collected data on respondents......’ facial attractiveness as well as data on SES, marital, and health outcomes from their mid-20s to their mid-60s. I find that beauty has lasting positive returns for women since more beautiful women have higher SES throughout their working life, have a higher probability of being married at age 25...

  1. Industrial entrepreneurial network: Structural and functional analysis

    Science.gov (United States)

    Medvedeva, M. A.; Davletbaev, R. H.; Berg, D. B.; Nazarova, J. J.; Parusheva, S. S.

    2016-12-01

    Structure and functioning of two model industrial entrepreneurial networks are investigated in the present paper. One of these networks is forming when implementing an integrated project and consists of eight agents, which interact with each other and external environment. The other one is obtained from the municipal economy and is based on the set of the 12 real business entities. Analysis of the networks is carried out on the basis of the matrix of mutual payments aggregated over the certain time period. The matrix is created by the methods of experimental economics. Social Network Analysis (SNA) methods and instruments were used in the present research. The set of basic structural characteristics was investigated: set of quantitative parameters such as density, diameter, clustering coefficient, different kinds of centrality, and etc. They were compared with the random Bernoulli graphs of the corresponding size and density. Discovered variations of random and entrepreneurial networks structure are explained by the peculiarities of agents functioning in production network. Separately, were identified the closed exchange circuits (cyclically closed contours of graph) forming an autopoietic (self-replicating) network pattern. The purpose of the functional analysis was to identify the contribution of the autopoietic network pattern in its gross product. It was found that the magnitude of this contribution is more than 20%. Such value allows using of the complementary currency in order to stimulate economic activity of network agents.

  2. Causative get-constructions in the dialogued passages in F. Scott Fitzgerald’s novels The Beautiful and Damned and Tender Is the Night as gender-conditioned structures

    Directory of Open Access Journals (Sweden)

    Gołąbek Rafał

    2015-05-01

    Full Text Available It goes without saying that in modern sociolinguistics there is a consensus with regard to the fact that the language of males and females differs. The initial sections of the article briefly address the peculiarities of gendered speech as to provide a theoretical background for checking whether the causative get is used similarly or differently by men and women in the two of F. Scott Fitzgerald’s novels: The Beautiful and Damned and Tender Is the Night. The basic expectation formed is that the motifs for triggering the use of causative get are of social rather than structural nature. Before the analysis is carried out, the group of the English periphrastic causatives are sketchily characterized. Generally, what has been found is that there is a clear, socially-motivated pattern of how F. Scott Fitzgerald uses the causative get in the dialogued occurrences in his two novels. Get is a characteristic of men’s talk, but it is also the expected form while female characters address male ones - hence the verb is labelled as “masculine” get. Moreover, it has been discovered that there does not seem to be any particular pattern in either the speaker’s mood or the speaker’s attitude expressed that would trigger the use of the causative verb in question. Yet, what seems to be a well-defined tendency, when it comes to the speaker-hearer power relation, is that the speaker usually assumes a more superior position than the hearer when he or she uses the causative verb. The superiority in most cases is strongly associated with masculinity. Hence, what is postulated is that the causative get is labelled not only as “masculine" but also as “superior”.

  3. Perceived beauty of random texture patterns: A preference for complexity.

    Science.gov (United States)

    Friedenberg, Jay; Liby, Bruce

    2016-07-01

    We report two experiments on the perceived aesthetic quality of random density texture patterns. In each experiment a square grid was filled with a progressively larger number of elements. Grid size in Experiment 1 was 10×10 with elements added to create a variety of textures ranging from 10%-100% fill levels. Participants rated the beauty of the patterns. Average judgments across all observers showed an inverted U-shaped function that peaked near middle densities. In Experiment 2 grid size was increased to 15×15 to see if observers preferred patterns with a fixed density or a fixed number of elements. The results of the second experiment were nearly identical to that of the first showing a preference for density over fixed element number. Ratings in both studies correlated positively with a GIF compression metric of complexity and with edge length. Within the range of stimuli used, observers judge more complex patterns to be more beautiful.

  4. Structural and functional neuroimaging in intractable epilepsy

    Directory of Open Access Journals (Sweden)

    Chinchure Swati

    2010-01-01

    Full Text Available Medical management remains unsatisfactory in about a third of patients with epilepsy and some of them are candidates for resective epilepsy surgery. Structural and functional neuroimaging plays an important role in the identification of the precise cortical region responsible for seizures and is very crucial for a good surgical outcome. Furthermore, identification of eloquent cortical areas near the region to be resected is essential to avoid postoperative neurologic deficit. The magnetic resonance imaging (MRI protocol for epilepsy can be individually tailored depending on the seizure semiology and possibly electroencephalography. New MRI techniques demonstrate the structure of the brain in fine detail, help in understanding the underlying pathology, and demonstrate functional activity of the brain with high spatial and temporal resolution. Metabolic imaging techniques, such as positron emission tomography (PET and single photon emission tomography (SPECT visualize metabolic alterations of the brain in the ictal and interictal states. In MR-negative epilepsy patients, these techniques may have localizing value. The proper use and interpretation of the findings provided by these new technologies is crucial. In this review article, we discuss various conventional and advanced MRI techniques, interpretation of various findings, and the role of functional imaging modalities, such as functional MRI, PET, and SPECT in the localization of epileptogenic substrate as well as for understanding the pathophysiology, propagation, and neurochemical correlates of epilepsy.

  5. Is beauty skin deep – an approach to a beautiful face

    Directory of Open Access Journals (Sweden)

    Neerja Puri

    2014-07-01

    Full Text Available Everyone dreams of a beautiful and flawless face but true beauty is God given gift. Plastic surgery and various filler techniques can just highlight certain features and are just the temporary procedures. Features that further enhance the attractiveness of a beautiful face are the hair, skin, and teeth. These areas are the easiest to routinely enhance. There are many methods of facial sculpting including botulinum toxin, fillers and various other invasive plastic surgery techniques.

  6. The Relation between the ideal of beauty and dependent beauty in Kant's philosophy

    Directory of Open Access Journals (Sweden)

    Javad Amin

    2015-10-01

    Full Text Available Kant organizes his analysis in terms of four moments of the judgment of taste, each of which is supposed to contribute something essential to the complete exposition of the beautiful in "Critique of Judgment". He, in the third moment, based on the key concept analysis of "purposiveness", reaches to the beauty definition "a purposiveness without a purpose" (subjective purposiveness. Below this moment, two concepts of "dependent beauty" and "the ideal of beauty" also arises that aesthetic judgment in both of them is based on an objective purposiveness and a concept indicating nature of the object and the perfection of the object that is considered as default for judgment. This default in dependent beauty is perfection of the object and in the ideal of beauty is a concept from the sum of the rational idea and the aesthetic normal idea, but this point of view is in contradiction with the principle of Kant's aesthetic, which judgment of the beautiful just relies on the subjective purposiveness. This article reviewing the concept of purposiveness and the type of subjective purposiveness in the ideal of beauty and dependent beauty, attempts to explain the aesthetic value of these concepts and their differences and similarities, and finally to determine the position of these two concepts in Kant's philosophy.

  7. Neuroaesthetics and the trouble with beauty.

    Directory of Open Access Journals (Sweden)

    Bevil R Conway

    Full Text Available Neuroscience is increasingly being called upon to address issues within the humanities. We discuss challenges that arise, relating to art and beauty, and provide ideas for a way forward.

  8. Phenylalanine hydroxylase: function, structure, and regulation.

    Science.gov (United States)

    Flydal, Marte I; Martinez, Aurora

    2013-04-01

    Mammalian phenylalanine hydroxylase (PAH) catalyzes the rate-limiting step in the phenylalanine catabolism, consuming about 75% of the phenylalanine input from the diet and protein catabolism under physiological conditions. In humans, mutations in the PAH gene lead to phenylketonuria (PKU), and most mutations are mainly associated with PAH misfolding and instability. The established treatment for PKU is a phenylalanine-restricted diet and, recently, supplementation with preparations of the natural tetrahydrobiopterin cofactor also shows effectiveness for some patients. Since 1997 there has been a significant increase in the understanding of the structure, catalytic mechanism, and regulation of PAH by its substrate and cofactor, in addition to improved correlations between genotype and phenotype in PKU. Importantly, there has also been an increased number of studies on the structure and function of PAH from bacteria and lower eukaryote organisms, revealing an additional anabolic role of the enzyme in the synthesis of melanin-like pigments. In this review, we discuss these recent studies, which contribute to define the evolutionary adaptation of the PAH structure and function leading to sophisticated regulation for effective catabolic processing of phenylalanine in mammalian organisms.

  9. The structure and function of presynaptic endosomes

    Energy Technology Data Exchange (ETDEWEB)

    Jähne, Sebastian, E-mail: sebastian.jaehne1@stud.uni-goettingen.de [Department of Neuro- and Sensory Physiology, University of Göttingen Medical Center, Cluster of Excellence Nanoscale Microscopy and Molecular Physiology of the Brain, Humboldtallee 23, 37073 Göttingen (Germany); International Max Planck Research School for Neurosciences, 37077 Göttingen (Germany); Rizzoli, Silvio O. [Department of Neuro- and Sensory Physiology, University of Göttingen Medical Center, Cluster of Excellence Nanoscale Microscopy and Molecular Physiology of the Brain, Humboldtallee 23, 37073 Göttingen (Germany); Helm, Martin S., E-mail: martin.helm@med.uni-goettingen.de [Department of Neuro- and Sensory Physiology, University of Göttingen Medical Center, Cluster of Excellence Nanoscale Microscopy and Molecular Physiology of the Brain, Humboldtallee 23, 37073 Göttingen (Germany); International Max Planck Research School for Molecular Biology, 37077 Göttingen (Germany)

    2015-07-15

    The function of endosomes and of endosome-like structures in the presynaptic compartment is still controversial. This is in part due to the absence of a consensus on definitions and markers for these compartments. Synaptic endosomes are sometimes seen as stable organelles, permanently present in the synapse. Alternatively, they are seen as short-lived intermediates in synaptic vesicle recycling, arising from the endocytosis of large vesicles from the plasma membrane, or from homotypic fusion of small vesicles. In addition, the potential function of the endosome is largely unknown in the synapse. Some groups have proposed that the endosome is involved in the sorting of synaptic vesicle proteins, albeit others have produced data that deny this possibility. In this review, we present the existing evidence for synaptic endosomes, we discuss their potential functions, and we highlight frequent technical pitfalls in the analysis of this elusive compartment. We also sketch a roadmap to definitely determine the role of synaptic endosomes for the synaptic vesicle cycle. Finally, we propose a common definition of synaptic endosome-like structures.

  10. STRUCTURE AND GRAMMATICAL FUNCTION OF LEO LANGUAGE

    Directory of Open Access Journals (Sweden)

    I Ketut Yudha

    2015-01-01

    Full Text Available Lio language is a language spoken in Central Flores. Having limited morphological process in general and affixation process involving verbs (head marking and nouns (dependent marking in particular, it is classified into an isolating language. The studies exploring the languages spoken in the eastern part of Indonesia using Lexical Functional Grammar and the theory of typology are highly limited. In addition, Lio language is merely an isolating one and does not have cross referencing. It is this which inspired the writer to conduct research in syntax. This study aims at investigating the canonic structure, the types of verbs used as predicates, the grammatical function, the alternate of clausal structure, the mapping and the pivotance in Lio language. The results of analysis show that the clauses in Lio language can be divided into basic clauses with verbal and nonverbal predicates. The  predicates of the verbal clauses are classified into simple, serial, and causative.  The serial verbal constructions are distinguished based on the semantic features of the verbal components forming the serial verbal constructions. These types can be observed from the nature of the relationships among the components forming the serial verbal constructions. A serial verbal construction is made up of more than one verbs and behaves as a simple predicate. There is no dependence marker among the components forming the serial verb.  The causative structure also forms monoclause and biclause. The functional mapping uses the features [+/-r] and [+/-o], the argument uses the features [-r] and [-o] which are mapped to  SUBJ, [-r] and [+o] are mapped to OBJ, [+r] and [+o] are mapped to OBJ2 or OBJ? and [+r] and [-o] are mapped to OBL (Oblique. Lio language has GF SUBJ and OBJ as the nuclear GF (nuclear grammatical function, and OBL, COMP, and ADJ as the nonnuclear grammatical functions. The SUBJ appears before the verb (preverbal position and the OBJ appears after the

  11. Tropomyosin structure and function new insights.

    Science.gov (United States)

    Muthuchamy, M; Rethinasamy, P; Wieczorek, D F

    1997-05-01

    Cardiac muscle contraction is dependent upon a cooperative interaction between thick and thin filament sarcomeric proteins. Tropomyosin (TM), an essential thin filament protein, interacts with actin and the troponin complex to regulate contractile activity. During muscle contraction, an increase of calcium (Ca(2+)) in the myofilament space promotes binding of Ca(2+) to troponin C, which alters the conformational state of TM and facilitates acto-myosin interactions. By coupling classic genetic approaches with recent developments in transgenic animal model systems, new insights have been provided on the functional role of TM isoforms in both normal and disease states. The focus of this article is to review the current state of knowledge on TM structure and function, with a particular emphasis on myocardial expression in transgenic mouse model systems. (Trends Cardiovasc Med 1997;7:124-128). © 1997, Elsevier Science Inc.

  12. MRI in Optic Neuritis: Structure, Function, Interactions

    DEFF Research Database (Denmark)

    Fuglø, Dan

    2011-01-01

    resonance imaging (MRI), and the visual evoked potential (VEP) continues to show a delayed P100 indicating persistent demyelination. The explanation for this apparent discrepancy between structure and function could be due to either a redundancy in the visual pathways so that some degree of signal loss...... are low. Functional MRI (fMRI) is a non-invasive technique that can measure brain activity with a high spatial resolution. Recently, technical and methodological advancements have made it feasible to record VEPs and fMRI simultaneously and the relationship between averaged VEPs and averaged fMRI signals...... have been described. Still, to take full advantage of simultaneously recorded VEP-fMRI one would ideally want to track single-trial changes in the VEP and use this information in the fMRI analysis. In order to do this we examined 10 healthy volunteers with simultaneous VEP-fMRI. Different measures...

  13. Soft matter nanotechnology from structure to function

    CERN Document Server

    Chen, Xiaodong

    2015-01-01

    Using the well-honed tools of nanotechnology, this book presents breakthrough results in soft matter research, benefitting from the synergies between the chemistry, physics, biology, materials science, and engineering communities. The team of international authors delves beyond mere structure-making and places the emphasis firmly on imparting functionality to soft nanomaterials with a focus on devices and applications. Alongside reviewing the current level of knowledge, they also put forward novel ideas to foster research and development in such expanding fields as nanobiotechnology and nanom

  14. The beauty of knots at the molecular level.

    Science.gov (United States)

    Sauvage, Jean-Pierre; Amabilino, David B

    2012-01-01

    What makes a given object look beautiful to the observer, be it in the macroscopic world or at the molecular level? This very general question will be briefly addressed at the beginning of this essay, in relation to contemporary molecular chemistry and biology, leading to the general statement that, most of the time, beauty is tightly connected to function as well as to the cultural background of the observer. The main topic of the present article will be that of topologically non-trivial molecules or molecular ensembles and the fascination that such species have exerted on molecular or solid state chemists. Molecules with a graph identical to Kuratowski's K₅ or K₃,₃ graphs are indeed highly attractive from an aesthetical viewpoint, but perhaps even more fascinating and beautiful are molecular knots. A general discussion will be devoted to these compounds, which are still considered as exotic species because of the very limited number of efficient synthetic strategies leading to their preparation. Particularly efficient are templated approaches based either on transition metals such as copper(I) or on organic groups able to form hydrogen bonds or acceptor-donor stacks. A particularly noteworthy property of knots, and in particular of the trefoil knot, is their topological chirality. The isolation of both enantiomers of the trefoil knot (3₁) could be achieved and showed that such species have fascinating chiroptical properties. Finally, various routes to more complex and beautiful knots than the trefoil knot, which is the simplest non-trivial knot, will be discussed in line with the remarkable ability of transition metals to gather and orient in a very precise fashion several organic components in their coordination spheres, thus leading to synthetic precursors displaying geometries which are perfectly well adapted to the preparation of the desired knots or links.

  15. The Ten Most Beautiful Experiments

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, George [The New York Times

    2010-10-20

    "Science in the 21st century has become industrialized. The experiments so often celebrated in the newspapers - sequencing the genome, proving the existence of the top quark, discovering a new planet by analyzing the wobble of a distant start - cost millions of dollars. They generate terabytes of data to be analyzed by supercomputers, calculating factories that spew out so much heat that they are equipped with cooling stacks and consume the energy of a small town. The experiments are carried out by research teams that have grown to the size of small corporations. But until very recently the most earth-shaking science came from individual pairs of hands. From a single mind confronting the unknown. The great experiments that mark the edges of our understanding were most often performed by one or two scientists and usually on a tabletop. Computation, if there was any, was carried out on paper or later with a slide rule. These experiments were designed and conducted with such straightforward elegance that they deserve to be called beautiful." (excerpt from the slide presentation accompanying the video)

  16. Materialised Ideals Sizes and Beauty

    Directory of Open Access Journals (Sweden)

    Kirsi Laitala

    2011-04-01

    Full Text Available Today’s clothing industry is based on a system where clothes are made in ready-to-wear sizes and meant to fit most people. Studies have pointed out that consumers are discontent with the use of these systems: size designations are not accurate enough to find clothing that fits, and different sizes are poorly available. This article discusses in depth who these consumers are, and which consumer groups are the most dissatisfied with today’s sizing systems. Results are based on a web survey where 2834 Nordic consumers responded, complemented with eight in-depth interviews, market analysis on clothing sizes and in-store trouser size measurements. Results indicate that higher shares of the consumers who have a body out of touch with the existing beauty ideals express discontentment with the sizing systems and the poor selection available. In particular, large women, very large men, and thin, short men are those who experience less priority in clothing stores and have more difficulties in finding clothes that fit. Consumers tend to blame themselves when the clothes do not fit their bodies, while our study points out that the industry is to blame as they do not produce clothing for all customers.

  17. Structure, expression and functions of MTA genes.

    Science.gov (United States)

    Kumar, Rakesh; Wang, Rui-An

    2016-05-15

    Metastatic associated proteins (MTA) are integrators of upstream regulatory signals with the ability to act as master coregulators for modifying gene transcriptional activity. The MTA family includes three genes and multiple alternatively spliced variants. The MTA proteins neither have their own enzymatic activity nor have been shown to directly interact with DNA. However, MTA proteins interact with a variety of chromatin remodeling factors and complexes with enzymatic activities for modulating the plasticity of nucleosomes, leading to the repression or derepression of target genes or other extra-nuclear and nucleosome remodeling and histone deacetylase (NuRD)-complex independent activities. The functions of MTA family members are driven by the steady state levels and subcellular localization of MTA proteins, the dynamic nature of modifying signals and enzymes, the structural features and post-translational modification of protein domains, interactions with binding proteins, and the nature of the engaged and resulting features of nucleosomes in the proximity of target genes. In general, MTA1 and MTA2 are the most upregulated genes in human cancer and correlate well with aggressive phenotypes, therapeutic resistance, poor prognosis and ultimately, unfavorable survival of cancer patients. Here we will discuss the structure, expression and functions of the MTA family of genes in the context of cancer cells.

  18. Latent structures of female sexual functioning.

    Science.gov (United States)

    Carvalho, Joana; Vieira, Armando Luís; Nobre, Pedro

    2012-08-01

    For the last three decades, male and female sexual responses have been conceptualized as similar, based on separated and sequential phases as proposed by the models of Masters and Johnson (1966) and Kaplan (1979) model. However, there is a growing debate around the need to conceptualize female sexual response and the classification of sexual dysfunction in women, in view of the upcoming editions of the DSM and ICD. The aim of this study was to test, using structural equation modeling, five conceptual, alternative models of female sexual function, using a sample of women with sexual difficulties and a sample of women without sexual problems. A total of 1993 Portuguese women participated in the study and completed a modified version of the Female Sexual Function Index. Findings suggested a four-factor solution as the model that best fit the data regarding women presenting sexual difficulties: (1) desire/arousal; (2) lubrication; (3) orgasm; (4) pain/vaginismus. In relation to sexually healthy women, the best model was a five-factor solution comprising of (1) desire; (2) arousal; (3) lubrication; (4) orgasm; and (5) pain/vaginismus. Discriminant validity between factors was supported, suggesting that these dimensions measure distinct phenomena. Model fit to the data significantly decreased in both samples, as models began to successively consider greater levels of overlap among phases of sexual function, towards a single-factor solution. By suggesting the overlap between pain and vaginismus, results partially support the new classification that is currently being discussed regarding DSM-5. Additionally, results on the relationship between sexual desire and arousal were inconclusive as sexually healthy women were better characterized by a five-factor model that considered the structural independence among these factors, whereas women with sexual difficulties better fit with a four-factor model merging sexual desire and subjective sexual arousal.

  19. Evaluation of Eyelid Function and Aesthetics.

    Science.gov (United States)

    Neimkin, Michael G; Holds, John B

    2016-05-01

    The eyes and periocular area are the central aesthetic unit of the face. Facial aging is a dynamic process that involves skin, subcutaneous soft tissues, and bony structures. An understanding of what is perceived as youthful and beautiful is critical for success. Knowledge of the functional aspects of the eyelid and periocular area can identify pre-preoperative red flags.

  20. Charm and beauty quark masses in the MMHT2014 global PDF analysis

    Science.gov (United States)

    Harland-Lang, L. A.; Martin, A. D.; Motylinski, P.; Thorne, R. S.

    2016-01-01

    We investigate the variation in the MMHT2014 PDFs when we allow the heavy-quark masses m_c and m_b to vary away from their default values. We make PDF sets available in steps of Δ m_c =0.05 GeV and Δ m_b =0.25 GeV, and present the variation in the PDFs and in the predictions. We examine the comparison to the HERA data on charm and beauty structure functions and note that in each case the heavy-quark data, and the inclusive data, have a slight preference for lower masses than our default values. We provide PDF sets with three and four active quark flavours, as well as the standard value of five flavours. We use the pole mass definition of the quark masses, as in the default MMHT2014 analysis, but briefly comment on the overline{MS} definition.

  1. Measurement of beauty and charm production in deep inelastic scattering with the ZEUS detector at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Brock, Ian C.; Shehzadi, Ramoona; Juengst, Markus [Physikalisches Institut, University of Bonn (Germany); Roloff, Philipp; Libov, Vladyslav [DESY, Hamburg (Germany); University of Hamburg (Germany)

    2011-07-01

    The study of heavy flavour production in ep collisions is one of the main research topics at HERA. In two recent analyses the production of heavy quarks in deep inelastic scattering has been studied with the ZEUS detector using the full HERA II dataset. In one of these analyses, the heavy flavour events were identified using electrons from semileptonic decays. The fractions of events containing the heavy quarks were extracted from a likelihood fit using variables sensitive to electron identification as well as to semileptonic decays. In the second analysis, the heavy flavour content in events with a jet was extracted using the decay length significance and invariant mass of the secondary vertices. Total and differential cross sections were measured and compared with next-to-leading-order QCD calculations and Monte Carlo models. The beauty and charm contributions to the proton structure function F{sub 2}, were extracted from the double-differential cross sections.

  2. Charm and beauty quark masses in the MMHT2014 global PDF analysis

    CERN Document Server

    Harland-Lang, L A; Motylinski, P; Thorne, R S

    2016-01-01

    We investigate the variation in the MMHT2014 PDFs when we allow the heavy quark masses $m_c$ and $m_b$ to vary away from their default values. We make PDF sets available in steps of $\\Delta m_c =0.05~{\\rm GeV}$ and $\\Delta m_b =0.25~{\\rm GeV}$, and present the variation in the PDFs and in the predictions. We examine the comparison to the HERA data on charm and beauty structure functions and note that in each case the heavy quark data, and the inclusive data, have a slight preference for lower masses than our default values. We provide PDF sets with 3 and 4 active quark flavours, as well as the standard value of 5 flavours. We use the pole mass definition of the quark masses, as in the default MMHT2014 analysis, but briefly comment on the $\\overline{\\rm MS}$ definition.

  3. Charm and beauty quark masses in the MMHT2014 global PDF analysis

    Energy Technology Data Exchange (ETDEWEB)

    Harland-Lang, L.A.; Motylinski, P.; Thorne, R.S. [University College London, Department of Physics and Astronomy, London (United Kingdom); Martin, A.D. [Durham University, Institute for Particle Physics Phenomenology, Durham (United Kingdom)

    2016-01-15

    We investigate the variation in the MMHT2014 PDFs when we allow the heavy-quark masses m{sub c} and m{sub b} to vary away from their default values.Wemake PDF sets available in steps of Δm{sub c} = 0.05 GeV and Δm{sub b} = 0.25 GeV, and present the variation in the PDFs and in the predictions. We examine the comparison to the HERA data on charm and beauty structure functions and note that in each case the heavy-quark data, and the inclusive data, have a slight preference for lower masses than our default values.We provide PDF sets with three and four active quark flavours, as well as the standard value of five flavours. We use the pole mass definition of the quark masses, as in the default MMHT2014 analysis, but briefly comment on the MS definition. (orig.)

  4. Charm and beauty quark masses in the MMHT2014 global PDF analysis

    Energy Technology Data Exchange (ETDEWEB)

    Harland-Lang, L. A. [Department of Physics and Astronomy, University College London, WC1E 6BT, London (United Kingdom); Martin, A. D. [Institute for Particle Physics Phenomenology, Durham University, DH1 3LE, Durham (United Kingdom); Motylinski, P.; Thorne, R. S., E-mail: thorne@hep.ucl.ac.uk [Department of Physics and Astronomy, University College London, WC1E 6BT, London (United Kingdom)

    2016-01-06

    We investigate the variation in the MMHT2014 PDFs when we allow the heavy-quark masses m{sub c} and m{sub b} to vary away from their default values. We make PDF sets available in steps of Δm{sub c}=0.05 GeV and Δm{sub b}=0.25 GeV, and present the variation in the PDFs and in the predictions. We examine the comparison to the HERA data on charm and beauty structure functions and note that in each case the heavy-quark data, and the inclusive data, have a slight preference for lower masses than our default values. We provide PDF sets with three and four active quark flavours, as well as the standard value of five flavours. We use the pole mass definition of the quark masses, as in the default MMHT2014 analysis, but briefly comment on the (MS)-bar definition.

  5. Deep inelastic beauty production at HERA in the k{sub T}-factorization approach

    Energy Technology Data Exchange (ETDEWEB)

    Lipatov, A.V.; Zotov, N.P. [M.V. Lomonosov Moscow State Univ., Moscow (Russian Federation). D.V. Skobeltsyn Institute of Nuclear Physics

    2006-05-15

    We calculate the cross section of beauty production in electron-proton deep inelastic scattering at HERA collider in the framework of the k{sub t}-factorization approach. The unintegrated gluon distributions in a proton are obtained from the full CCFM, from unified BFKL-DGLAP evolution equations as well as from the Kimber-Martin-Ryskin prescription. We investigate different production rates and study the b-quark contribution to the inclusive proton structure function F{sub 2}(x,Q{sup 2}) at small x and at moderate and high values of Q{sup 2}. Our theoretical results are compared with the recent experimental data taken by the H1 and ZEUS collaborations. We demonstrate the importance of leading ln 1/x contributions in description of the HERA data. (Orig.)

  6. Structural and functional diversity of desmosomes.

    Science.gov (United States)

    Harmon, Robert M; Green, Kathleen J

    2013-12-01

    Desmosomes anchor intermediate filaments at sites of cell contact established by the interaction of cadherins extending from opposing cells. The incorporation of cadherins, catenin adaptors, and cytoskeletal elements resembles the closely related adherens junction. However, the recruitment of intermediate filaments distinguishes desmosomes and imparts a unique function. By linking the load-bearing intermediate filaments of neighboring cells, desmosomes create mechanically contiguous cell sheets and, in so doing, confer structural integrity to the tissues they populate. This trait and a well-established role in human disease have long captured the attention of cell biologists, as evidenced by a publication record dating back to the mid-1860s. Likewise, emerging data implicating the desmosome in signaling events pertinent to organismal development, carcinogenesis, and genetic disorders will secure a prominent role for desmosomes in future biological and biomedical investigations.

  7. Structural and Functional Views of Mechatronic Products

    DEFF Research Database (Denmark)

    Nielsen, Kjeld; Petersen, Thomas Ditlev; Jørgensen, Kaj Asbjørn

    2011-01-01

    The development and subsequent production of industrial products are often complicated tasks. The complication increases with combined product as mechatronic products and is further complicated when large variety is required. Modularity is often used to achieve optimum in these complications both...... in the costumer view as well in the production view. In this paper, the relationships in mechatronic products between the functional and structural levels are explored in relation to modularity. A list of commonly used module drivers is presented and a qualitative survey is used to explore significance...... of influence on these module drivers when applying mechatronic product technology and view levels. The result is summarized in a list of which drivers should be addressed in a mechatronic product approach to modularity. Keywords:...

  8. Structure-function relationships in calpains.

    Science.gov (United States)

    Campbell, Robert L; Davies, Peter L

    2012-11-01

    Calpains are a family of complex multi-domain intracellular enzymes that share a calcium-dependent cysteine protease core. These are not degradative enzymes, but instead carry out limited cleavage of target proteins in response to calcium signalling. Selective cutting of cytoskeletal proteins to facilitate cell migration is one such function. The two most abundant and extensively studied members of this family in mammals, calpains 1 and 2, are heterodimers of an isoform-specific 80 kDa large subunit and a common 28 kDa small subunit. Structures of calpain-2, both Ca2+-free and bound to calpastatin in the activated Ca2+-bound state, have provided a wealth of information about the enzyme's structure-function relationships and activation. The main association between the subunits is the pairing of their C-terminal penta-EF-hand domains through extensive intimate hydrophobic contacts. A lesser contact is made between the N-terminal anchor helix of the large subunit and the penta-EF-hand domain of the small subunit. Up to ten Ca2+ ions are co-operatively bound during activation. The anchor helix is released and individual domains change their positions relative to each other to properly align the active site. Because calpains 1 and 2 require ~30 and ~350 μM Ca2+ ions for half-maximal activation respectively, it has long been argued that autoproteolysis, subunit dissociation, post-translational modifications or auxiliary proteins are needed to activate the enzymes in the cell, where Ca2+ levels are in the nanomolar range. In the absence of robust support for these mechanisms, it is possible that under normal conditions calpains are transiently activated by high Ca2+ concentrations in the microenvironment of a Ca2+ influx, and then return to an inactive state ready for reactivation.

  9. Wavelets and Geometric Structure for Function Spaces

    Institute of Scientific and Technical Information of China (English)

    Qi Xiang YANG

    2004-01-01

    With Littlewood-Paley analysis, Peetre and Triebel classified, systematically, almost all the usual function spaces into two classes of spaces: Besov spaces (B)s,q p(s ∈ R,0 < p,q ≤∞) and Triebel-Lizorkin spaces (F)s,q p(s∈R,0<p<∞,0<q≤∞); but the structure of dual spaces (D)s,q p of (F)s,q p(s∈R, 0<p≤1≤q≤∞) is very different from that of Besov spaces or that of Triebel-Lizorkin spaces, and their structure cannot be analysed easily in the Littlewood-Paley analysis. Our main goal is to characterize (D)s,q p (s ∈ R, 0<p= 1≤q≤∞) in tent spaces with wavelets. By the way, some applications are given: (i) Triebel-Lizorkin spaces for p = ∞ defined by Littlewood-Paley analysis cannot serve as the dual spaces of Triebel-Lizorkin spaces for p = 1; (ii) Some inclusion relations among these above spaces and some relations among(B)o,q1,(F)o,q1 and L1 are studied.

  10. Intrinsically disordered proteins: structural and functional dynamics

    Directory of Open Access Journals (Sweden)

    Wallin S

    2017-02-01

    Full Text Available Stefan Wallin Department of Physics and Physical Oceanography, Memorial University of Newfoundland, St. John’s, NL, Canada Abstract: The classical view holds that proteins fold into essentially unique three-dimensional structures before becoming biologically active. However, studies over the last several years have provided broad and convincing evidence that some proteins do not adopt a single structure and yet are fully functional. These intrinsically disordered proteins (IDPs have been found to be highly prevalent in many genomes, including human, and play key roles in central cellular processes, such as regulation of transcription and translation, cell cycle, and cell signaling. Moreover, IDPs are overrepresented among proteins implicated in disease, including various cancers and neurodegenerative disorders. Intense efforts, by using both experimental and computational approaches, are consequently under way to uncover the molecular mechanisms that underpin the roles of IDPs in biology and disease. This review provides an introduction to the general biophysical properties of IDPs and discusses some of the recent emerging areas in IDP research, including the roles of IDPs in allosteric regulation, regulatory unfolding, and formation of intracellular membrane-less organelles. In addition, recent attempts at therapeutic targeting of IDPs by small molecules, noting in particular that IDPs represent a potentially important source of new drug targets in light of their central role in protein–protein interaction networks, are also reviewed. Keywords: natively unfolded proteins, unstructured proteins, protein folding, protein–protein interaction, cell regulation, signaling, drug development, inhibitors

  11. Structure, Function, and Evolution of Rice Centromeres

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, Jiming

    2010-02-04

    The centromere is the most characteristic landmark of eukaryotic chromosomes. Centromeres function as the site for kinetochore assembly and spindle attachment, allowing for the faithful pairing and segregation of sister chromatids during cell division. Characterization of centromeric DNA is not only essential to understand the structure and organization of plant genomes, but it is also a critical step in the development of plant artificial chromosomes. The centromeres of most model eukaryotic species, consist predominantly of long arrays of satellite DNA. Determining the precise DNA boundary of a centromere has proven to be a difficult task in multicellular eukaryotes. We have successfully cloned and sequenced the centromere of rice chromosome 8 (Cen8), representing the first fully sequenced centromere from any multicellular eukaryotes. The functional core of Cen8 spans ~800 kb of DNA, which was determined by chromatin immunoprecipitation (ChIP) using an antibody against the rice centromere-specific H3 histone. We discovered 16 actively transcribed genes distributed throughout the Cen8 region. In addition to Cen8, we have characterized eight additional rice centromeres using the next generation sequencing technology. We discovered four subfamilies of the CRR retrotransposon that is highly enriched in rice centromeres. CRR elements are constitutively transcribed and different CRR subfamilies are differentially processed by RNAi. These results suggest that different CRR subfamilies may play different roles in the RNAi-mediated pathway for formation and maintenance of centromeric chromatin.

  12. The Structural and Functional Organisation of Cognition.

    Directory of Open Access Journals (Sweden)

    Peter John Snow

    2016-10-01

    Full Text Available This paper proposes that what have been historically and contemporarily defined as different domains of human cognition are served by one of four functionally- and structurally-distinct areas of the prefrontal cortex. Their contributions to human intelligence are as follows: (a BA9, enables our emotional intelligence, engaging the psychosocial domain, (b BA47, enables our practical intelligence, engaging the material domain, (c BA46 (or BA46-9/46, enables our abstract intelligence, engaging the hypothetical domain and (d BA10, enables our temporal intelligence, engaging in planning within any of the other three domains. Given their unique contribution to human cognition, it is proposed that these areas be called the, social (BA9, material (BA47, abstract (BA46-9/46 and temporal (BA10 mind. The evidence that BA47 participates strongly in verbal and gestural communication suggests that language evolved primarily as a consequence of the extreme selective pressure for practicality; an observation supported by the functional connectivity between BA47 and orbital areas that negatively reinforce lying. It is further proposed that the abstract mind (BA46-9/46 is the primary seat of metacognition charged with creating adaptive behavioral strategies by generating higher-order concepts (hypotheses from lower-order concepts originating both from our perceptual representations and the other three domains of cognition.

  13. The Structural and Functional Organization of Cognition.

    Science.gov (United States)

    Snow, Peter J

    2016-01-01

    This article proposes that what have been historically and contemporarily defined as different domains of human cognition are served by one of four functionally- and structurally-distinct areas of the prefrontal cortex (PFC). Their contributions to human intelligence are as follows: (a) BA9, enables our emotional intelligence, engaging the psychosocial domain; (b) BA47, enables our practical intelligence, engaging the material domain; (c) BA46 (or BA46-9/46), enables our abstract intelligence, engaging the hypothetical domain; and (d) BA10, enables our temporal intelligence, engaging in planning within any of the other three domains. Given their unique contribution to human cognition, it is proposed that these areas be called the, social (BA9), material (BA47), abstract (BA46-9/46) and temporal (BA10) mind. The evidence that BA47 participates strongly in verbal and gestural communication suggests that language evolved primarily as a consequence of the extreme selective pressure for practicality; an observation supported by the functional connectivity between BA47 and orbital areas that negatively reinforce lying. It is further proposed that the abstract mind (BA46-9/46) is the primary seat of metacognition charged with creating adaptive behavioral strategies by generating higher-order concepts (hypotheses) from lower-order concepts originating from the other three domains of cognition.

  14. The evolutionary psychology of facial beauty.

    Science.gov (United States)

    Rhodes, Gillian

    2006-01-01

    What makes a face attractive and why do we have the preferences we do? Emergence of preferences early in development and cross-cultural agreement on attractiveness challenge a long-held view that our preferences reflect arbitrary standards of beauty set by cultures. Averageness, symmetry, and sexual dimorphism are good candidates for biologically based standards of beauty. A critical review and meta-analyses indicate that all three are attractive in both male and female faces and across cultures. Theorists have proposed that face preferences may be adaptations for mate choice because attractive traits signal important aspects of mate quality, such as health. Others have argued that they may simply be by-products of the way brains process information. Although often presented as alternatives, I argue that both kinds of selection pressures may have shaped our perceptions of facial beauty.

  15. TV Beauty Ads and Role Expectations of Adolescent Female Viewers.

    Science.gov (United States)

    Tan, Alexis S.

    1979-01-01

    A study of the responses of 56 high school girls shows the cultivation effects of television beauty-related commercials on the girls' perceptions of the importance of sex appeal, youth, and beauty to women in four different roles. (GT)

  16. The Beautiful and Beauty in St. Thomas’ Commentary to De Divinis Nominibus

    Directory of Open Access Journals (Sweden)

    Hugo Costarelli Brandi

    2016-09-01

    Full Text Available The article is written in Spanish. While St. Thomas Aquinas has not written any separate treaty on beauty, the theme of beauty regularly appears in his writing from its very beginning as that which corresponds with the Platonic doctrine presented by Dionysius the Areopagite in his De Divinis Nominibus. The article is focused on three essential elements in Aquinas’ doctrine on beauty: 1 its identity with the subject, 2 its difference from the reason, and 3 its difference from the good.

  17. Beautiful skin%美丽肌肤

    Institute of Scientific and Technical Information of China (English)

    胡敏

    2012-01-01

    介绍了皮肤皱纹生成的机理,抗皱有效成分、作用机理以及皮肤的抗衰老护理。介绍了一些美容食品、抗老化美容成分以及最具潜力的原料来源。%The mechanism of skin wrinkle formation,the active ingredients of anti-aging,the mechanism of action as well as skin anti-aging care were introduced here.Some beautiful foods,anti-aging beautiful ingredients and the most interesting source of feed were also related.

  18. On the Beauty in Keats’s Ode to Autumn

    Institute of Scientific and Technical Information of China (English)

    谭凯

    2011-01-01

    Keats’s poems are famous for beauty,and Ode to Autumn is generally regarded as one of his most beautiful poems.In this ode,Keats presents a vivid picture of the harvesting autumn,in which many forms of beauty can be captured.The present paper attempts to conduct an analysis of the beauty in Keats’s Ode to Autumn,hopefully it could help readers better understand Keats and his works.

  19. Structure-based inference of molecular functions of proteins of unknown function from Berkeley Structural Genomics Center.

    Science.gov (United States)

    Shin, Dong Hae; Hou, Jingtong; Chandonia, John-Marc; Das, Debanu; Choi, In-Geol; Kim, Rosalind; Kim, Sung-Hou

    2007-09-01

    Advances in sequence genomics have resulted in an accumulation of a huge number of protein sequences derived from genome sequences. However, the functions of a large portion of them cannot be inferred based on the current methods of sequence homology detection to proteins of known functions. Three-dimensional structure can have an important impact in providing inference of molecular function (physical and chemical function) of a protein of unknown function. Structural genomics centers worldwide have been determining many 3-D structures of the proteins of unknown functions, and possible molecular functions of them have been inferred based on their structures. Combined with bioinformatics and enzymatic assay tools, the successful acceleration of the process of protein structure determination through high throughput pipelines enables the rapid functional annotation of a large fraction of hypothetical proteins. We present a brief summary of the process we used at the Berkeley Structural Genomics Center to infer molecular functions of proteins of unknown function.

  20. Structure-based inference of molecular functions of proteins of unknown function from Berkeley Structural Genomics Center

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sung-Hou; Shin, Dong Hae; Hou, Jingtong; Chandonia, John-Marc; Das, Debanu; Choi, In-Geol; Kim, Rosalind; Kim, Sung-Hou

    2007-09-02

    Advances in sequence genomics have resulted in an accumulation of a huge number of protein sequences derived from genome sequences. However, the functions of a large portion of them cannot be inferred based on the current methods of sequence homology detection to proteins of known functions. Three-dimensional structure can have an important impact in providing inference of molecular function (physical and chemical function) of a protein of unknown function. Structural genomics centers worldwide have been determining many 3-D structures of the proteins of unknown functions, and possible molecular functions of them have been inferred based on their structures. Combined with bioinformatics and enzymatic assay tools, the successful acceleration of the process of protein structure determination through high throughput pipelines enables the rapid functional annotation of a large fraction of hypothetical proteins. We present a brief summary of the process we used at the Berkeley Structural Genomics Center to infer molecular functions of proteins of unknown function.

  1. Anisotropic nanomaterials: structure, growth, assembly, and functions.

    Science.gov (United States)

    Sajanlal, Panikkanvalappil R; Sreeprasad, Theruvakkattil S; Samal, Akshaya K; Pradeep, Thalappil

    2011-01-01

    Comprehensive knowledge over the shape of nanomaterials is a critical factor in designing devices with desired functions. Due to this reason, systematic efforts have been made to synthesize materials of diverse shape in the nanoscale regime. Anisotropic nanomaterials are a class of materials in which their properties are direction-dependent and more than one structural parameter is needed to describe them. Their unique and fine-tuned physical and chemical properties make them ideal candidates for devising new applications. In addition, the assembly of ordered one-dimensional (1D), two-dimensional (2D), and three-dimensional (3D) arrays of anisotropic nanoparticles brings novel properties into the resulting system, which would be entirely different from the properties of individual nanoparticles. This review presents an overview of current research in the area of anisotropic nanomaterials in general and noble metal nanoparticles in particular. We begin with an introduction to the advancements in this area followed by general aspects of the growth of anisotropic nanoparticles. Then we describe several important synthetic protocols for making anisotropic nanomaterials, followed by a summary of their assemblies, and conclude with major applications.

  2. Anisotropic nanomaterials: structure, growth, assembly, and functions

    Directory of Open Access Journals (Sweden)

    Panikkanvalappil R. Sajanlal

    2011-02-01

    Full Text Available Comprehensive knowledge over the shape of nanomaterials is a critical factor in designing devices with desired functions. Due to this reason, systematic efforts have been made to synthesize materials of diverse shape in the nanoscale regime. Anisotropic nanomaterials are a class of materials in which their properties are direction-dependent and more than one structural parameter is needed to describe them. Their unique and fine-tuned physical and chemical properties make them ideal candidates for devising new applications. In addition, the assembly of ordered one-dimensional (1D, two-dimensional (2D, and three-dimensional (3D arrays of anisotropic nanoparticles brings novel properties into the resulting system, which would be entirely different from the properties of individual nanoparticles. This review presents an overview of current research in the area of anisotropic nanomaterials in general and noble metal nanoparticles in particular. We begin with an introduction to the advancements in this area followed by general aspects of the growth of anisotropic nanoparticles. Then we describe several important synthetic protocols for making anisotropic nanomaterials, followed by a summary of their assemblies, and conclude with major applications.

  3. 75 FR 21595 - Beauty and Cosmetics Trade Mission to India

    Science.gov (United States)

    2010-04-26

    ... International Trade Administration Beauty and Cosmetics Trade Mission to India AGENCY: International Trade... Beauty and Cosmetics Trade Mission to India (New Delhi, Mumbai and Bangalore), November 15-19, 2010. Led... Indian market. The cosmetics/ beauty industry is one of the booming retail sectors in India with...

  4. 75 FR 33763 - Beauty and Cosmetics Trade Mission to India

    Science.gov (United States)

    2010-06-15

    ... International Trade Administration Beauty and Cosmetics Trade Mission to India AGENCY: International Trade... Beauty and Cosmetics Trade Mission to India (New Delhi, Mumbai and Bangalore), November 15-19, 2010. Led.... The cosmetics/beauty industry is one of the booming retail sectors in India with very strong...

  5. Walking in Beauty: An American Indian Perspective on Social Justice

    Science.gov (United States)

    Eason, Evan Allen; Robbins, Rockey

    2012-01-01

    The purpose of this article is to introduce "walking in beauty," an American Indian spiritual perspective related to social justice that emphasizes beauty, harmony, connectedness/unity of experience, and imagination. Walking in beauty includes 3 processes: embodiment, creativity, and appreciation of the sublime. Recommendations are offered for…

  6. Sexual selection, redundancy and survival of the most beautiful

    Indian Academy of Sciences (India)

    R D Morris; J A Morris

    2004-09-01

    A model is described of a highly redundant complex organism that has overlapping banks of genes such that each vital function is specified by several different genetic systems. This generates a synergistic profile linking probability of survival to the number of deleterious mutations in the genome. Computer models show that there is a dynamic interaction between the mean number of new deleterious mutations per generation (), the mean number of deleterious mutations in the genome of the population () and percentage zygote survival (Zs). Increased leads to increased and a fall in Zs but it takes several generations before a new equilibrium is reached. If sexual attraction is influenced by the number of deleterious mutations in the genome of individuals then is reduced and Zs increased for any given value of . This fall in and rise in Zs is more marked in polygamous than monogamous mating systems. The model is specified such that deleterious mutations can occur without any observable or measurable effect on function. Thus sexual selection, in this organism, for low levels of deleterious mutations cannot be based on assessment of performance. Instead it is based on a simple symmetrical surface pattern that is flawlessly reproduced by organisms with no deleterious mutations, but is less than perfect, and therefore less attractive, if genetic systems have been deleted. A complex vital task requires a system with a high level of redundancy that acts so that the loss of one component has no observable effect and therefore cannot be used for sexual selection. The reproduction of a beautiful surface pattern also requires a low error, high redundancy genetic system; however, in this case there is advantage if a single deleterious mutation produces a recognisable change. This leads to the conclusion that sexual selection and sexual attraction should be based on beauty rather than utility, and explains the common observation in nature that it is the most beautiful that

  7. Perception of the beauty and body image in Czech Republic, Slovakia and Hungary with application on beauty industry

    OpenAIRE

    Chotváč, Richard

    2012-01-01

    ABSTRACT CHOTVÁČ, Richard: Perception of beauty and body image in Czech Republic, Slovakia and Hungary and its application in beauty industry. [Master thesis] -- University of Economics in Prague, VŠE. Faculty of Business Administration; Tutor: doc. Ing. Jan Koudelka, CSc. Prague: VŠE, 2013, 82pages. The Master thesis deals with the perception of the beauty in 3 countries, Czech Republic, Slovakia and Hungary. This thesis is showing differences between the perception of body image and beauty ...

  8. Towards Reengineering the United States Department of Defense: A Financial Case for a Functionally-Aligned, Unified Military Structure

    Science.gov (United States)

    2014-03-01

    identify actual costs of DoD functions. v DEDICATION Soli Deo Gloria To my beautiful ...must develop an activity dictionary identifying the activities it performs. An activity is a verb and an associated object, i.e. fly aircraft. This

  9. Structure and function of the archaeal exosome.

    Science.gov (United States)

    Evguenieva-Hackenberg, Elena; Hou, Linlin; Glaeser, Stefanie; Klug, Gabriele

    2014-01-01

    The RNA-degrading exosome in archaea is structurally very similar to the nine-subunit core of the essential eukaryotic exosome and to bacterial polynucleotide phosphorylase (PNPase). In contrast to the eukaryotic exosome, PNPase and the archaeal exosome exhibit metal ion-dependent, phosphorolytic activities and synthesize heteropolymeric RNA tails in addition to the exoribonucleolytic RNA degradation in 3' → 5' direction. The archaeal nine-subunit exosome consists of four orthologs of eukaryotic exosomal subunits: the RNase PH-domain-containing subunits Rrp41 and Rrp42 form a hexameric ring with three active sites, whereas the S1-domain-containing subunits Rrp4 and Csl4 form an RNA-binding trimeric cap on the top of the ring. In vivo, this cap contains Rrp4 and Csl4 in variable amounts. Rrp4 confers poly(A) specificity to the exosome, whereas Csl4 is involved in the interaction with the archaea-specific subunit of the complex, the homolog of the bacterial primase DnaG. The archaeal DnaG is a highly conserved protein and its gene is present in all sequenced archaeal genomes, although the exosome was lost in halophilic archaea and some methanogens. In exosome-containing archaea, DnaG is tightly associated with the exosome. It functions as an additional RNA-binding subunit with poly(A) specificity in the reconstituted exosome of Sulfolobus solfataricus and enhances the degradation of adenine-rich transcripts in vitro. Not only the RNA-binding cap but also the hexameric Rrp41-Rrp42 ring alone shows substrate selectivity and prefers purines over pyrimidines. This implies a coevolution of the exosome and its RNA substrates resulting in 3'-ends with different affinities to the exosome.

  10. Poplus Diversifolia:The Most Beautiful Tree

    Institute of Scientific and Technical Information of China (English)

    ZhanHua

    2004-01-01

    Populus diversifolia,an old and rare tree species,is an only tree variety that can naturally grow into forest in Xinjiang's deserts.It is called "Tokolako"in the Uigur language,meaning"the most beautiful tree".Its extraordinary resistance to drought,sand wind and sanitization enables it to thrive in deserts and gains it repute

  11. Why Beautiful People Are More Intelligent

    Science.gov (United States)

    Kanazawa, Satoshi; Kovar, Jody L.

    2004-01-01

    Empirical studies demonstrate that individuals perceive physically attractive others to be more intelligent than physically unattractive others. While most researchers dismiss this perception as a ''bias'' or ''stereotype,'' we contend that individuals have this perception because beautiful people indeed "are" more intelligent. The conclusion that…

  12. Beauty baryon decays: a theoretical overview

    Science.gov (United States)

    Wang, Yu-Ming

    2014-11-01

    I overview the theoretical status and recent progress on the calculations of beauty baryon decays focusing on the QCD aspects of the exclusive semi-leptonic Λb → plμ decay at large recoil and theoretical challenges of radiative and electro-weak penguin decays Λb → Λγ,Λl+l-.

  13. Beauty as Fit: A Metaphor in Mathematics?

    Science.gov (United States)

    Raman, Manya; Öhman, Lars-Daniel

    2013-01-01

    Beauty, which plays a central role in the practice of mathematics (Sinclair 2002), is almost absent in discussions of school mathematics (Dreyfus and Eisenberg 1986). This is problematic, because students will decide whether or not to continue their studies in mathematics without having an accurate picture of what the subject is about. In order to…

  14. Beauty, a road to the truth

    NARCIS (Netherlands)

    Kuipers, T.A.F.

    2002-01-01

    In this article I give a naturalistic-cum-formal analysis of the relation between beauty, empirical success, and truth. The analysis is based on the one hand on a hypothetical variant of the so-called 'mere-exposure effect' which has been more or less established in experimental psychology regarding

  15. The Beauty of Painting in English Writing

    Institute of Scientific and Technical Information of China (English)

    郝艳慧

    2016-01-01

    English writing ability is emphasized in English teaching without any doubt. And this article attempts to reexamine the teaching of writing and explain the nature of writing from an aesthetic perspective-its beauty of painting. Hope either teachers or students could make a deep aesthetic understanding of English writing from this article.

  16. Miss International Beauty Pageant in China

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ The 47th Miss International Beauty Pageant, jointly sponsored by China Youth Concern Committee for the Advancement of Health and Physical Culture Development, International Culture Association, Kessles Paris, International Culture Exchange Organization,and co-organized by Beijing Kessles International Culture Media Co., Ltd., will be held in Beijing, China, according to the press conference on March 21.

  17. The Beautiful Physics of LHC Run 2

    CERN Document Server

    AUTHOR|(CDS)2108556

    2015-01-01

    Run 2 of the LHC offers some beautiful prospects for new physics, including flavour physics as well as more detailed studies of the Higgs boson and searches for new physics beyond the Standard Model (BSM). One of the possibilities for BSM physics is supersymmetry, and flavour physics plays various important r\\^oles in constraining supersymmetric models.

  18. Differences in perceptions of beauty and cosmetic procedures performed in ethnic patients.

    Science.gov (United States)

    Talakoub, Lily; Wesley, Naissan O

    2009-06-01

    The United States has become progressively more multicultural, with the ethnic population growing at record rates. The US Census Bureau projects that, by the year 2056, greater than 50% of the US population will be of non-Caucasian descent. Ethnic patients have different cosmetic concerns and natural features that are unique. The cosmetic concerns of ethnic patients also differ as the result of differences in skin pathophysiology, mechanisms of aging, and unique anatomic structure. There is no longer a single standard of beauty. We must now adapt to the more diverse population and understand how to accommodate the diversity of beauty in the United States. Ethnic patients do not necessarily want a Westernized look because what constitutes beauty is determined by racial, cultural, and environmental influences. We as leaders in skin care must understand these differences and adapt our practices accordingly. This article will focus on the differences in aging in different ethnic populations and highlight procedures unique to skin of color.

  19. Measurement of beauty photoproduction using decays into muons in dijet events at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Chekanov, S.; Derrick, M.; Magill, S. [Argonne National Lab., Argonne, IL (US)] (and others)

    2008-12-15

    Beauty photoproduction in dijet events has been measured at HERA with the ZEUS detector using an integrated luminosity of 126 pb{sup -1}. Beauty was identified in events with a muon in the final state by using the transverse momentum of the muon relative to the closest jet. Lifetime information from the silicon vertex detector was also used; the impact parameter of the muon with respect to the primary vertex was exploited to discriminate between signal and background. Cross sections for beauty production as a function of the muon and the jet variables as well as dijet correlations are compared to QCD predictions and to previous measurements. The data are well described by predictions from next-to-leading-order QCD. (orig.)

  20. Measurement of beauty photoproduction using decays into muons in di-jet events at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Haas, Tobias; Geiser, Achim [Deutsches Elektronen-Synchrotron - DESY, Platanenallee 6, D-15738 Zeuthen (Germany); Reisert, Burkard [Max Planck Institute for Physics - Werner-Heisenberg-Institut, Foehringer Ring 6, 80805 Muenchen (Germany); Tassi, Enrico [Dipartimento di Fisica, Universita della Calabria, Via P. Bucci 31C, 87036 Rende - CS (Italy)

    2010-07-01

    Beauty photoproduction in di-jet events has been measured at HERA with the ZEUS detector using an integrated luminosity of 126 pb{sup -1}. Beauty was identified in events with a muon in the final state by using the transverse momentum of the muon relative to the closest jet. Lifetime information from the silicon vertex detector was also used; the impact parameter of the muon with respect to the primary vertex was exploited to discriminate between signal and background. Cross sections for beauty production as a function of the muon and the jet variables as well as di-jet correlations are compared to QCD predictions and to previous measurements. The data are well described by predictions from next-to-leading-order QCD. (author)

  1. Contributions of Consumer-perceived Creativity and Beauty to Willingness-to-pay for Design Products

    DEFF Research Database (Denmark)

    Christensen, Bo Thomas; Kristensen, Tore; Reber, Rolf

    2015-01-01

    Consumer perception of creativity in design products equivalent in function was measured using global single-item ratings of creativity. The measure was found to have a high level of agreement between raters and have discriminant validity to another aesthetic construct, that of beauty. In two...... experiments using designer lamps and wrist watches as stimuli, the present study shows how creativity and beauty both positively influence consumer willingness-to-pay (WtP) for the designed product, but each explains different parts of the variance. The results show that it is essential to develop separate...... models of creativity and beauty evaluations in consumer psychology, in that they seem to be distinct factors, explaining different parts of the variance in their consequences on WtP....

  2. 右美托咪定对丙泊酚复合瑞芬太尼用于脑功能区术中唤醒麻醉的影响探析%Right beauty's microphones set for complex ray fentanyl propofol used for brain functional areas of wake up the anesthesia effect analysis

    Institute of Scientific and Technical Information of China (English)

    查木哈格

    2015-01-01

    Objective to study the composite rui fentanyl propofol anesthesia technique used in the right brain function cannot set the wake effect of beauty.Methods 60 regular during perioperative period in patients with brain function research, randomly divided into treatment group and control group. Two groups of anesthesia method is the same, before anesthesia induction in patients with treatment group and control group respectively intravenous injection of saline and right beauty holds the mi. Observation compared two groups of patients in mean arterial pressure of different time and wake up time, incidence of body movement, choking incidence of cough.Results the treatment group of mean arterial pressure were lower than the control group at the time of withdrawal, wake up; The body move incidence of treatment group, the incidence of choking cough is lower than the control group,P 0.05, there was no statistically significant difference. Conclusion line for induction of general anesthesia surgery patients with right cerebral function beauty cannot decide it is better to wake up, suitable for clinical popularization.%目的:研究丙泊酚复合瑞芬太尼麻醉脑功能区术中使用右美托咪定的唤醒效果。方法对60例行脑功能区手术患者进行研究,随机分成治疗组与对照组。两组麻醉方法相同,在麻醉诱导前对治疗组与对照组患者分别静脉注入生理盐水与右美托咪定。观察对比两组患者在不同时刻的平均动脉压和唤醒时间、体动发生率、呛咳发生率。结果治疗组的平均动脉压在停药时、唤醒时均低于对照组;治疗组的体动发生率、呛咳发生率低于对照组,P0.05,差异无统计学意义。结论对行全麻诱导的脑功能区手术患者使用右美托咪定唤醒效果较好,适合在临床推普及。

  3. Beauty and Brains: Detecting Anomalous Pattern Co-Occurrences

    OpenAIRE

    Bertens, Roel; Vreeken, Jilles; Siebes, Arno

    2015-01-01

    Our world is filled with both beautiful and brainy people, but how often does a Nobel Prize winner also wins a beauty pageant? Let us assume that someone who is both very beautiful and very smart is more rare than what we would expect from the combination of the number of beautiful and brainy people. Of course there will still always be some individuals that defy this stereotype; these beautiful brainy people are exactly the class of anomaly we focus on in this paper. They do not posses intri...

  4. Nucleon structure functions in noncommutative space-time

    CERN Document Server

    Rafiei, Ali; Mirjalili, Abolfazl

    2016-01-01

    In the context of noncommutative space-time, we investigate the nucleon structure functions which plays an important role to identify the internal structure of nucleons. We use the corrected vertices and employ new vertices that appear in two approaches of noncommutativity and calculate the proton structure functions in terms of noncommutative tensor \\theta_{\\mu\

  5. Natural Tendency towards Beauty in Humans: Evidence from Binocular Rivalry.

    Directory of Open Access Journals (Sweden)

    Ce Mo

    Full Text Available Although human preference for beauty is common and compelling in daily life, it remains unknown whether such preference is essentially subserved by social cognitive demands or natural tendency towards beauty encoded in the human mind intrinsically. Here we demonstrate experimentally that humans automatically exhibit preference for visual and moral beauty without explicit cognitive efforts. Using a binocular rivalry paradigm, we identified enhanced gender-independent perceptual dominance for physically attractive persons, and the results suggested universal preference for visual beauty based on perceivable forms. Moreover, we also identified perceptual dominance enhancement for characters associated with virtuous descriptions after controlling for facial attractiveness and vigilance-related attention effects, which suggested a similar implicit preference for moral beauty conveyed in prosocial behaviours. Our findings show that behavioural preference for beauty is driven by an inherent natural tendency towards beauty in humans rather than explicit social cognitive processes.

  6. Natural Tendency towards Beauty in Humans: Evidence from Binocular Rivalry.

    Science.gov (United States)

    Mo, Ce; Xia, Tiansheng; Qin, Kaixin; Mo, Lei

    2016-01-01

    Although human preference for beauty is common and compelling in daily life, it remains unknown whether such preference is essentially subserved by social cognitive demands or natural tendency towards beauty encoded in the human mind intrinsically. Here we demonstrate experimentally that humans automatically exhibit preference for visual and moral beauty without explicit cognitive efforts. Using a binocular rivalry paradigm, we identified enhanced gender-independent perceptual dominance for physically attractive persons, and the results suggested universal preference for visual beauty based on perceivable forms. Moreover, we also identified perceptual dominance enhancement for characters associated with virtuous descriptions after controlling for facial attractiveness and vigilance-related attention effects, which suggested a similar implicit preference for moral beauty conveyed in prosocial behaviours. Our findings show that behavioural preference for beauty is driven by an inherent natural tendency towards beauty in humans rather than explicit social cognitive processes.

  7. The structural basis of nuclear function.

    Science.gov (United States)

    Jackson, D A; Cook, P R

    1995-01-01

    Most models for transcription and replication involve polymerases that track along the template. We review here experiments that suggest an alternative in which polymerization occurs as the template slides past a polymerase fixed to a large structure in the eukaryotic nucleus--a "factory" attached to a nucleoskeleton. This means that higher-order structure dictates how and when DNA is replicated or transcribed.

  8. Measurement of the Electron Structure Function at LEP energies

    CERN Document Server

    Abdallah, J; Adam, W; Adzic, P; Albrecht, T; Alemany-Fernandez, R; Allmendinger, T; Allport, P P; Amaldi, U; Amapane, N; Amato, S; Anashkin, E; Andreazza, A; Andringa, S; Anjos, N; Antilogus, P; Apel, W-D; Arnoud, Y; Ask, S; Asman, B; Augustin, J E; Augustinus, A; Baillon, P; Ballestrero, A; Bambade, P; Barbier, R; Bardin, D; Barker, G J; Baroncelli, A; Battaglia, M; Baubillier, M; Becks, K-H; Begalli, M; Behrmann, A; Ben-Haim, E; Benekos, N; Benvenuti, A; Berat, C; Berggren, M; Bertrand, D; Besancon, M; Besson, N; Bloch, D; Blom, M; Bluj, M; Bonesini, M; Boonekamp, M; Booth, P S L; Borisov, G; Botner, O; Bouquet, B; Bowcock, T J V; Boyko, I; Bracko, M; Brenner, R; Brodet, E; Bruckman, P; Brunet, J M; Buschbeck, B; Buschmann, P; Calvi, M; Camporesi, T; Canale, V; Carena, F; Castro, N; Cavallo, F; Chapkin, M; Charpentier, Ph; Checchia, P; Chierici, R; Chliapnikov, P; Chudoba, J; Chung, S U; Cieslik, K; Collins, P; Contri, R; Cosme, G; Cossutti, F; Costa, M J; Crennell, D; Cuevas, J; D'Hondt, J; da Silva, T; Da Silva, W; Della Ricca, G; De Angelis, A; De Boer, W; De Clercq, C; De Lotto, B; De Maria, N; De Min, A; de Paula, L; Di Ciaccio, L; Di Simone, A; Doroba, K; Drees, J; Eigen, G; Ekelof, T; Ellert, M; Elsing, M; Espirito Santo, M C; Fanourakis, G; Fassouliotis, D; Feindt, M; Fernandez, J; Ferrer, A; Ferro, F; Flagmeyer, U; Foeth, H; Fokitis, E; Fulda-Quenzer, F; Fuster, J; Gandelman, M; Garcia, C; Gavillet, Ph; Gazis, E; Gokieli, R; Golob, B; Gomez-Ceballos, G; Goncalves, P; Graziani, E; Grosdidier, G; Grzelak, K; Guy, J; Haag, C; Hallgren, A; Hamacher, K; Hamilton, K; Haug, S; Hauler, F; Hedberg, V; Hennecke, M; Hoffman, J; Holmgren, S-O; Holt, P J; Houlden, M A; Jackson, J N; Jarlskog, G; Jarry, P; Jeans, D; Johansson, E K; Jonsson, P; Joram, C; Jungermann, L; Kapusta, F; Katsanevas, S; Katsoufis, E; Kernel, G; Kersevan, B P; Kerzel, U; King, B T; Kjaer, N J; Kluit, P; Kokkinias, P; Kourkoumelis, C; Kouznetsov, O; Krumstein, Z; Kucharczyk, M; Lamsa, J; Leder, G; Ledroit, F; Leinonen, L; Leitner, R; Lemonne, J; Lepeltier, V; Lesiak, T; Liebig, W; Liko, D; Lipniacka, A; Lopes, J H; Lopez, J M; Loukas, D; Lutz, P; Lyons, L; MacNaughton, J; Malek, A; Maltezos, S; Mandl, F; Marco, J; Marco, R; Marechal, B; Margoni, M; Marin, J-C; Mariotti, C; Markou, A; Martinez-Rivero, C; Masik, J; Mastroyiannopoulos, N; Matorras, F; Matteuzzi, C; Mazzucato, F; Mazzucato, M; Mc Nulty, R; Meroni, C; Migliore, E; Mitaroff, W; Mjoernmark, U; Moa, T; Moch, M; Moenig, K; Monge, R; Montenegro, J; Moraes, D; Moreno, S; Morettini, P; Mueller, U; Muenich, K; Mulders, M; Mundim, L; Murray, W; Muryn, B; Myatt, G; Myklebust, T; Nassiakou, M; Navarria, F; Nawrocki, K; Nemecek, S; Nicolaidou, R; Nikolenko, M; Oblakowska-Mucha, A; Obraztsov, V; Olshevski, A; Onofre, A; Orava, R; Osterberg, K; Ouraou, A; Oyanguren, A; Paganoni, M; Paiano, S; Palacios, J P; Palka, H; Papadopoulou, Th D; Pape, L; Parkes, C; Parodi, F; Parzefall, U; Passeri, A; Passon, O; Peralta, L; Perepelitsa, V; Perrotta, A; Petrolini, A; Piedra, J; Pieri, L; Pierre, F; Pimenta, M; Piotto, E; Podobnik, T; Poireau, V; Pol, M E; Polok, G; Pozdniakov, V; Pukhaeva, N; Pullia, A; Radojicic, D; Rebecchi, P; Rehn, J; Reid, D; Reinhardt, R; Renton, P; Richard, F; Ridky, J; Rivero, M; Rodriguez, D; Romero, A; Ronchese, P; Roudeau, P; Rovelli, T; Ruhlmann-Kleider, V; Ryabtchikov, D; Sadovsky, A; Salmi, L; Salt, J; Sander, C; Savoy-Navarro, A; Schwickerath, U; Sekulin, R; Siebel, M; Sisakian, A; Slominski, W; Smadja, G; Smirnova, O; Sokolov, A; Sopczak, A; Sosnowski, R; Spassov, T; Stanitzki, M; Stocchi, A; Strauss, J; Stugu, B; Szczekowski, M; Szeptycka, M; Szumlak, T; Szwed, J; Tabarelli, T; Tegenfeldt, F; Timmermans, J; Tkatchev, L; Tobin, M; Todorovova, S; Tome, B; Tonazzo, A; Tortosa, P; Travnicek, P; Treille, D; Tristram, G; Trochimczuk, M; Troncon, C; Turluer, M L; Tyapkin, I A; Tyapkin, P; Tzamarias, S; Uvarov, V; Valenti, G; Van Dam, P; Van Eldik, J; van Remortel, N; Van Vulpen, I; Vegni, G; Veloso, F; Venus, W; Verdier, P; Verzi, V; Vilanova, D; Vitale, L; Vrba, V; Wahlen, H; Washbrook, A J; Weiser, C; Wicke, D; Wickens, J; Wilkinson, G; Winter, M; Witek, M; Yushchenko, O; Zalewska, A; Zalewski, P; Zavrtanik, D; Zhuravlov, V; Zimin, N I; Zintchenko, A; Zupan, M

    2010-01-01

    The hadronic part of the Electron Structure Function (ESF) has been measured for the first time, using e+e- data collected by the DELPHI experiment at LEP, at centre-of-mass energies sqrt(s) = 91.2-209.5 GeV. The data analysis is simpler than that of the measurement of the photon structure function. The ESF data are compared to predictions of phenomenological models based on the photon structure function. It is shown that the quasi-real photon virtuality contribution is significant. The presented data can serve as a cross-check of the photon structure function analyses and help in refining existing parametrizations.

  9. Calculation of the Gluon Distribution Function Using Alternative Method for the Proton Structure Function

    Institute of Scientific and Technical Information of China (English)

    N. Ghahramany; G.R. Boroun

    2003-01-01

    A calculation of the proton structure function F2(x,Q2) is reported with an approximation method that relates the reduced cross section derivative and the F2(x, Q2) scaling violation at low x by using quadratic form for the structure function. This quadratic form approximation method can be used to determine the structure function F2 (x, Q2)from the HERA reduced cross section data taken at low x. This new approach can determine the structure functions F2(x,Q2) with reasonable precision even for low x values which have not been investigated. We observe that the Q2 dependence is quadratic over the full kinematic covered range. To test the validity of our new determined structure functions, wefind the gluon distribution function in the leading order approximation with our new calculation for the structure functions and compare them with the QCD parton distribution functions.

  10. Calculation of the Gluon Distribution Function Using Alternative Method for the Proton Structure Function

    Institute of Scientific and Technical Information of China (English)

    N.Ghahramany; G.R.Boroun

    2003-01-01

    A calculation of the proton structure function F2(x,Q2) is reported with an approximation method that relates the reduced cross section derivative and the F2(x, Q2) scaling violation at low x by using quadratic form for the structure function. This quadratic form approximation method can be used to determine the structure function F2 (x, Q2) from the HERA reduced cross section data taken at low x. This new approach can determine the structure functions F2(x,Q2) with reasonable precision even for low x values which have not been investigated. We observe that the Q2 dependence is quadratic over the full kinematic covered range. To test the validity of our new determined structure functions, we find the gluon distribution function in the leading order approximation with our new calculation for the structure functions and compare them with the QCD parton distribution functions.

  11. Structure and function of yeast alcohol dehydrogenase

    Directory of Open Access Journals (Sweden)

    VLADIMIR LESKOVAC

    2000-04-01

    Full Text Available 1. Introduction 2. Isoenzymes of YADH 3. Substrate specificity 4. Kinetic mechanism 5. Primary structure 6. The active site 7. Mutations in the yeast enzyme 8. Chemical mechanism 9. Binding of coenzymes 10. Hydride transfer

  12. Structure and function of yeast alcohol dehydrogenase

    OpenAIRE

    VLADIMIR LESKOVAC; SVETLANA TRIVIC

    2000-01-01

    1. Introduction 2. Isoenzymes of YADH 3. Substrate specificity 4. Kinetic mechanism 5. Primary structure 6. The active site 7. Mutations in the yeast enzyme 8. Chemical mechanism 9. Binding of coenzymes 10. Hydride transfer

  13. El ojo hermoso The beautiful eye

    Directory of Open Access Journals (Sweden)

    O. M. Ramírez

    2007-06-01

    Full Text Available Como cirujanos estéticos siempre nos esforzamos por alcanzar resultados hermosos que sean agradables a los sentidos. Esto es particularmente cierto en el terreno del rejuvenecimiento periorbitario. Según la estadística de la Sociedad Americana de Cirujanos Plásticos la blefaroplastia estética es uno de los procedimientos mas frecuentes y su frecuencia va en aumento tanto en hombres como en mujeres. El rejuvenecimiento periorbitario adecuado debería restaurar la percepción interior del paciente respecto a belleza y juventud de sus ojos, así como proporcionar un aspecto externo que sea "estético" o agradable a los sentidos. Para lograr este objetivo, se requiere una comprensión de la estética facial, tanto en términos subjetivos como objetivos. Los investigadores han demostrado que la percepción del atractivo o la belleza en la cara de un individuo es relativamente constante entre observadores independientes, desafiando el dicho popular de que "la belleza está en el ojo del espectador." Presentamos una actualización del tema y una amplia iconografía. La información recogida de la literatura y de años experiencia clínica debería permitir al lector desarrollar una mayor sensibilidad estética, para obtener resultados óptimos en el rejuvenecimiento periorbitario.As aesthetic surgeons we are always striving to achieve beautiful results that are pleasurable to the senses. This is particularly certain in the land of the periorbital rejuvenation. According to the statistics of the American Society of Plastic Surgeons, aesthetic blepharoplasty is one of the procedures most commonly performed and goes in increase its so much frequency in men as in women. Successful periorbital rejuvenation should restore the patient"s inner sense of beauty and youthfulness as well as provide an outward appearance that is ‘aesthetic" or pleasurable to the senses. To accomplish this lofty goal, the aesthetic surgeon must strive to create "the beautiful

  14. Relativistic density functional for nuclear structure

    CERN Document Server

    2016-01-01

    This book aims to provide a detailed introduction to the state-of-the-art covariant density functional theory, which follows the Lorentz invariance from the very beginning and is able to describe nuclear many-body quantum systems microscopically and self-consistently. Covariant density functional theory was introduced in nuclear physics in the 1970s and has since been developed and used to describe the diversity of nuclear properties and phenomena with great success. In order to provide an advanced and updated textbook of covariant density functional theory for graduate students and nuclear physics researchers, this book summarizes the enormous amount of material that has accumulated in the field of covariant density functional theory over the last few decades as well as the latest developments in this area. Moreover, the book contains enough details for readers to follow the formalism and theoretical results, and provides exhaustive references to explore the research literature.

  15. Connectivity and functional profiling of abnormal brain structures in pedophilia.

    Science.gov (United States)

    Poeppl, Timm B; Eickhoff, Simon B; Fox, Peter T; Laird, Angela R; Rupprecht, Rainer; Langguth, Berthold; Bzdok, Danilo

    2015-06-01

    Despite its 0.5-1% lifetime prevalence in men and its general societal relevance, neuroimaging investigations in pedophilia are scarce. Preliminary findings indicate abnormal brain structure and function. However, no study has yet linked structural alterations in pedophiles to both connectional and functional properties of the aberrant hotspots. The relationship between morphological alterations and brain function in pedophilia as well as their contribution to its psychopathology thus remain unclear. First, we assessed bimodal connectivity of structurally altered candidate regions using meta-analytic connectivity modeling (MACM) and resting-state correlations employing openly accessible data. We compared the ensuing connectivity maps to the activation likelihood estimation (ALE) maps of a recent quantitative meta-analysis of brain activity during processing of sexual stimuli. Second, we functionally characterized the structurally altered regions employing meta-data of a large-scale neuroimaging database. Candidate regions were functionally connected to key areas for processing of sexual stimuli. Moreover, we found that the functional role of structurally altered brain regions in pedophilia relates to nonsexual emotional as well as neurocognitive and executive functions, previously reported to be impaired in pedophiles. Our results suggest that structural brain alterations affect neural networks for sexual processing by way of disrupted functional connectivity, which may entail abnormal sexual arousal patterns. The findings moreover indicate that structural alterations account for common affective and neurocognitive impairments in pedophilia. The present multimodal integration of brain structure and function analyses links sexual and nonsexual psychopathology in pedophilia.

  16. Connectivity and functional profiling of abnormal brain structures in pedophilia

    Science.gov (United States)

    Poeppl, Timm B.; Eickhoff, Simon B.; Fox, Peter T.; Laird, Angela R.; Rupprecht, Rainer; Langguth, Berthold; Bzdok, Danilo

    2015-01-01

    Despite its 0.5–1% lifetime prevalence in men and its general societal relevance, neuroimaging investigations in pedophilia are scarce. Preliminary findings indicate abnormal brain structure and function. However, no study has yet linked structural alterations in pedophiles to both connectional and functional properties of the aberrant hotspots. The relationship between morphological alterations and brain function in pedophilia as well as their contribution to its psychopathology thus remain unclear. First, we assessed bimodal connectivity of structurally altered candidate regions using meta-analytic connectivity modeling (MACM) and resting-state correlations employing openly accessible data. We compared the ensuing connectivity maps to the activation likelihood estimation (ALE) maps of a recent quantitative meta-analysis of brain activity during processing of sexual stimuli. Second, we functionally characterized the structurally altered regions employing meta-data of a large-scale neuroimaging database. Candidate regions were functionally connected to key areas for processing of sexual stimuli. Moreover, we found that the functional role of structurally altered brain regions in pedophilia relates to nonsexual emotional as well as neurocognitive and executive functions, previously reported to be impaired in pedophiles. Our results suggest that structural brain alterations affect neural networks for sexual processing by way of disrupted functional connectivity, which may entail abnormal sexual arousal patterns. The findings moreover indicate that structural alterations account for common affective and neurocognitive impairments in pedophilia. The present multi-modal integration of brain structure and function analyses links sexual and nonsexual psychopathology in pedophilia. PMID:25733379

  17. Hidden-beauty charged tetraquarks and heavy quark spin conservation

    Science.gov (United States)

    Ali, A.; Maiani, L.; Polosa, A. D.; Riquer, V.

    2015-01-01

    Assuming the dominance of the spin-spin interaction in a diquark, we point out that the mass difference in the beauty sector M (Zb')±-M (Zb)± scales with quark masses as expected in QCD, with respect to the corresponding mass difference M (Zc')±-M (Zc)± . Notably, we show that the decays ϒ (10890 )→ϒ (n S )π+π- and ϒ (10890 )→(hb(1 P ),hb(2 P ))π+π- are compatible with heavy quark spin conservation if the contributions of Zb,Zb' intermediate states are taken into account, ϒ (10890 ) being either a ϒ (5 S ) or the beauty analog of Yc(4260 ). Belle results on these decays support the quark spin wave function of the Z states as tetraquarks. We also consider the role of light quark spin nonconservaton in Zb,Zb' decays into B B* and B*B*. Indications of possible signatures of the still missing Xb resonance are proposed.

  18. Protein Structure and Function Prediction Using I-TASSER.

    Science.gov (United States)

    Yang, Jianyi; Zhang, Yang

    2015-12-17

    I-TASSER is a hierarchical protocol for automated protein structure prediction and structure-based function annotation. Starting from the amino acid sequence of target proteins, I-TASSER first generates full-length atomic structural models from multiple threading alignments and iterative structural assembly simulations followed by atomic-level structure refinement. The biological functions of the protein, including ligand-binding sites, enzyme commission number, and gene ontology terms, are then inferred from known protein function databases based on sequence and structure profile comparisons. I-TASSER is freely available as both an on-line server and a stand-alone package. This unit describes how to use the I-TASSER protocol to generate structure and function prediction and how to interpret the prediction results, as well as alternative approaches for further improving the I-TASSER modeling quality for distant-homologous and multi-domain protein targets.

  19. Beauty and ugliness in the bodies and faces of others: an fMRI study of person esthetic judgement.

    Science.gov (United States)

    Martín-Loeches, M; Hernández-Tamames, J A; Martín, A; Urrutia, M

    2014-09-26

    Whether beauty and ugliness represent two independent judgement categories or, instead, opposite extremes of a single dimension is a matter of debate. In the present 3T-functional Magnetic Resonance Imaging (fMRI) study, 20 participants were scanned while judging faces and nude bodies of people classified as extremely ugly, extremely beautiful, or indifferent. Certain areas, such as the caudate/nucleus accumbens (NAcc) and the anterior cingulate cortex (ACC), exhibited a linear relationship across esthetic judgments supporting ugliness as the lowest extreme of a beauty continuum. Other regions, such as basal occipital areas, displayed an inverse pattern, with the highest activations for ugly and the lowest for beautiful ones. Further, several areas were involved alike by both the very beautiful and the very ugly stimuli. Among these, the medial orbitofrontal cortex (mOFC), as well as the posterior and medial portions of the cingulate gyrus. This is interpreted as the activation of neural circuits related to self- vs. other-assessment. Beauty and ugliness in the brain, at least in relation to natural and biologically and socially relevant stimuli (faces and bodies), appear tightly related and non-independent. Finally, neutral stimuli elicited strong and wide activations of the somatosensory and somatomotor systems together with longer reaction times and higher error rates, probably reflecting the difficulty of the human brain to classify someone as indifferent.

  20. Controlling Function and Structure with DNA

    DEFF Research Database (Denmark)

    Tørring, Thomas

    2011-01-01

    In this thesis, the research on three different topics will be described. The overall area of the research is DNA nanotechnology, and the first chapter is therefore an introduction to DNA, and its advantages as a building material. The first research topic is the development of a new method...... investigated on a two dimensional DNA origami platform. This was done by incorporating functional groups on the surface of the origami, and reacting these with biotin analogues carrying the complementary functional groups. Successful reactions could then be observed using atomic force microscopy after addition...... of the protein streptavidin. While the implementation of chemical functionalities on origami can be achieved during automated DNA synthesis, this is laborious and costly. In a separate research project we aimed at improving the accessibility by applying an enzymatic labelling method. We demonstrated that the DNA...

  1. Truth, virtue and beauty: midwifery and philosophy.

    Science.gov (United States)

    Parker, J M; Gibbs, M

    1998-09-01

    In this paper, we outline three moments in the history of Western philosophy--Classical Greek, Modernity, Postmodernity--and the ways in which issues of truth, virtue and beauty have been understood within these philosophical formations. In particular, we investigate the ways in which notions of truth, virtue and beauty influenced the orthodoxy of birthing practices at these different moments. Finally, we examine current, critical reflections on the role of the intellectual in postmodern society and use these reflections as a heuristic for understanding the role of the contemporary midwife. We suggest that midwifery must reconcile two divergent demands. The first is to mobilise the positive, instrumental benefits of Western medical science to improve mortality and morbidity outcomes. The second is to remain sensitive to the cultural and social meanings attached to traditional birthing practices and to understand the roles these play in the well-being of mother and child.

  2. The Hidden Beauty in Biomedical Imaging.

    Science.gov (United States)

    Barker, Norman; Iacobuzio-Donahue, Christine

    2015-01-01

    Caretakers, researchers and photographers working in a busy academic settings, every day are faced with images that are awe-inspiring for their beauty and for the terror they may represent to patients suffering from disease. Beauty in this context is a relative term. It may be seen as the delicate lacework of cells within the normal human brain reminiscent of a Jackson Pollack masterpiece, or the multitude of colors and textures formed by fungal organisms in a microbiology lab. Herein lies the juxtaposition image makers seek to represent. When contemplated in isolation, each represents a visually interesting image. However, when viewed with an awareness of the context in which the image was obtained, each image takes on the ability to evoke an alternative human emotion.

  3. Charm and beauty production at RHIC

    Energy Technology Data Exchange (ETDEWEB)

    Kabana, Sonia [Laboratoire de Physique Subatomique et des Technologies Associees (SUBATECH), Ecole des Mines, 4 rue Alfred Kastler, 44307 Nantes (France)

    2011-01-15

    We review selected highlights on charm and beauty production at RHIC from p+p, d+Au and A+A collisions at {radical}(s{sub NN})=200GeV, and compare them to model calculations. We focus on two particular issues, jet quenching and quarkonia. Anomalous energy loss (jet quenching) of quarks passing through the dense and hot matter built in heavy ion collisions is one of the outstanding discoveries made at RHIC. This phenomenon allows for an estimate of the initial gluon density. Furthermore, color screening of hidden charm and beauty states is a key signature of the QCD phase transition, allowing an estimate of the initial temperature. We present results on the flavour dependence of jet quenching. Heavy flavour production in A+A as compared to p+p collisions will be discussed for open and hidden charm.

  4. Hidden Beauty in Twisted Viking Neck Rings

    CERN Document Server

    Olsen, Kasper

    2010-01-01

    Many hoards found in Ireland, Scotland, Orkney Islands, and Scandinavia demonstrate the vikings ability to fabricate beautiful arm and neck rings of twisted silver and gold rods. Characteristic for such rings is the uniform appearance of the twisted pattern along the length of the arm ring, as well as from one arm ring to another, also when found at distant geographical locations. How can the appearance of the twisted wires be so perfectly repetitive? We demonstrate that the answer is that the vikings utilized a self-forming motif: The pattern arises from a twisting of the wires to a maximally rotated configuration. That is why the twist patterns in these arm and neck rings are beautiful, repetitive, and universal.

  5. Non-leptonic decays of beauty decays

    CERN Document Server

    Bigi, Ikaros I; Shifman, M; Uraltsev, N; Vainshtein, A I

    1994-01-01

    "Anyone who keeps the ability to see beauty never grows old" (Franz Kafka). In the last few years considerable progress has been achieved in our understanding of the decays of heavy flavour hadrons. One can now calculate inclusive transition rates in QCD proper through an expansion in inverse powers of the heavy flavour quark mass without recourse to phenomenological assumptions. The non-perturbative contributions are treated systematically in this way; they are found to produce corrections of order a few percent in beauty decays, i.e. typically somewhat smaller than the perturbative corrections. One finds, among other things: (a) The lifetime of $B^-$ mesons is predicted to be longer than that of $B^0$ mesons by several percent. (b) The QCD prediction for the semileptonic branching ratio of $B$ mesons appears to exceed present experimental values.

  6. China's Most Beautiful Books

    Institute of Scientific and Technical Information of China (English)

    WuLiang

    2005-01-01

    “China's Most Beautiful Books 2004”, an annual national award for books' graphic design, came out in Shanghai in January, 2005. Twenty-four publications won the titles and were recommended to participate in “The Most Beautiful Books of the World 2005” competition which will be held in Leibzig, Germany. The award winners included both best sellers with simplistic design such as “Us Three” and “Niu Niu: A Father's Notes”, and thread-bound traditional books such as “Ma De's Painting Album”, “Nanmu Carvings in West of Hunan Province”, “Watch the Three Gorges” and “Culture of Southeast China: Key Words”。

  7. Nodal Structure of the Electronic Wigner Function

    DEFF Research Database (Denmark)

    Schmider, Hartmut; Dahl, Jens Peder

    1996-01-01

    On the example of several atomic and small molecular systems, the regular behavior of nodal patterns in the electronic one-particle reduced Wigner function is demonstrated. An expression found earlier relates the nodal pattern solely to the dot-product of the position and the momentum vector......, if both arguments are large. An argument analogous to the ``bond-oscillatory principle'' for momentum densities links the nuclear framework in a molecule to an additional oscillatory term in momenta parallel to bonds. It is shown that these are visible in the Wigner function in terms of characteristic...

  8. Structural plasticity upon learning: regulation and functions.

    Science.gov (United States)

    Caroni, Pico; Donato, Flavio; Muller, Dominique

    2012-07-01

    Recent studies have provided long-sought evidence that behavioural learning involves specific synapse gain and elimination processes, which lead to memory traces that influence behaviour. The connectivity rearrangements are preceded by enhanced synapse turnover, which can be modulated through changes in inhibitory connectivity. Behaviourally related synapse rearrangement events tend to co-occur spatially within short stretches of dendrites, and involve signalling pathways partially overlapping with those controlling the functional plasticity of synapses. The new findings suggest that a mechanistic understanding of learning and memory processes will require monitoring ensembles of synapses in situ and the development of synaptic network models that combine changes in synaptic function and connectivity.

  9. "Beauty lies in the eye of the beholder"? Aspects of beauty and attractiveness.

    Science.gov (United States)

    Borelli, Claudia; Berneburg, Mirjam

    2010-05-01

    Discussing aesthetic issues and their management with patients is a growing area of dermatologic practice. Sometimes treatment options within one's own discipline are rapidly discussed, without a clear idea of the various aspects of the face which all combine to produce beauty and attractiveness. We review various features leading to the impression of beauty and attractiveness. Familiarity with these concepts should facilitate a broader discussion with the patient on the aspects of beauty and attractiveness beyond the borders of one's own discipline and also lead to multidisciplinary treatment options. We also examine the question how much the personality of the beholder himself is involved in the perception of attractiveness and beauty (of the person sitting opposite to him). The "ideal" face has an average profile with slightly protrusive and full lips. Attractiveness increases with average features and symmetry. Moreover, particular features such as the scheme of childlike characteristics combined with aspects of maturity and expression make a female face appear especially beautiful. Which attributes contribute to attractiveness of a man's face are controversial. Clear male signals such as a strong chin are likely not to increase attractiveness.

  10. Types and Functions of Coastal Structures

    DEFF Research Database (Denmark)

    Burcharth, H. F.; A. Hughes, Steven

    2003-01-01

    Coastal structures are used in coastal defence schemes with the objective of preventing shoreline erosion and flooding of the hinterland. Other objectives include sheltering of harbour basins and harbour entrances against waves, stabilization of navigation channels at inlets, and protection of wa...... of water intakes and outfalls....

  11. Perceptions of beauty in Renaissance art.

    Science.gov (United States)

    Haughton, Neil

    2004-12-01

    The Renaissance was a cultural revolution that spread from Florence, in 1400, throughout Italy and into the rest of Europe. Its impetus was the philosophy of Humanism, which strove to resurrect and emulate the literature and art of the ancient Greeks and Romans. Artists had previously been limited to formulaic religious iconography. They now began to reproduce descriptions of classical paintings and copy the antique statues that were being newly rediscovered. The Renaissance artist's perception of beauty was therefore determined by his philosophical environment, his visual experience (the 'period eye'), the demands of his patrons and by attempts to enhance his professional status in society to equal that of poets and architects. The image of Venus portrayed by Botticelli as the idealization of beauty in Renaissance Florence is significantly different from the Venus portrayed by the German artist, Lucas Cranach. The northern European Venus is much less voluptuous than her Italian counterpart but is still inspired by humanist principals and retains considerable sexuality. Raphael's paintings epitomise the idealization of female beauty of this period but, by his own admission they were rarely based on real models. Often the same facial type was repeated in many different paintings. Indeed Renaissance portrait artists tended to avoid realistic interpretation, emphasizing instead the positive attributes of their subjects, both physical and political. Thus, Bronzino's Portrait of a Young Man not only depicts his subject's idealized appearance but also his scholarship, background and potential. The depiction of beauty in Renaissance art is shown to be more complex than a mere photograph-like representation of sexuality or of a person's physical appearance. Instead, Renaissance art created physically perfect images resulting from scholarly expectation, the artist's ambitions and his developing skills.

  12. Beautiful seasons of Pan’an

    Institute of Scientific and Technical Information of China (English)

    季陈熙; 陈妙芳

    2015-01-01

    I.m from Pan an,It s a small town of Zhejiang.Do you know?It s the most beautiful palce in my heart.Panan is a bes place to live.In Pan an,The water is clean,the trees are green,the air is very fresh.In an increasingly harsh environment,PM2.5 is also rampant worldwide,Pan an is getting more and more popula

  13. Beauty and ugliness in Olmec monumental sculpture

    OpenAIRE

    Baudez, Claude-François

    2015-01-01

    Beauty and ugliness in Olmec monumental sculpture. Since our Western art tradition has put such a prize on naturalism, we tend to think that other civilizations valued it as much as we did and do. I contend that Olmec monumental art illustrates the opposite, and suggest that the Olmecs most appreciated the anthropomorphic statues that incorporated feline features, and disliked the very naturalistic style of the colossal heads. The latter represented the severed heads of opponents who probably...

  14. Measurement of the beauty of periodic noises

    CERN Document Server

    Manet, Vincent

    2012-01-01

    In this article indicators to describe the "beauty" of noises are proposed. Rhythmic, tonal and harmonic suavity are introduced. They give a characterization of a noise in terms of rhythmic regularity (rhythmic suavity), of auditory pleasure of the "chords" constituting the signal (tonal suavity) and of the transition between the chords (harmonic suavity). These indicators have been developed for periodic noises typically issued from rotating machines such as engines, compressors... and are now used by our industrial customers since two years.

  15. BEAUTY IN THE AGE OF MARKETING

    OpenAIRE

    Bingqing Yin; Susie Pryor

    2012-01-01

    Research has repeatedly demonstrated that beauty is positively related to a number of important outcomes including social and personal power, self-esteem, and preferential treatment from others (Bloch and Richins, 1992; cf. Adams, 1977; Goldman and Lewis, 1977). Moreover, studies consistently suggest that the use of physically attractive models results in positive effects (Berscheid and Walster, 1974; Bower, 2011; Buunk and Dijkstra, 2011; Landy and Sigall, 1974). Accordingly, advertisers uti...

  16. The structure and function of endophilin proteins

    DEFF Research Database (Denmark)

    Kjaerulff, Ole; Brodin, Lennart; Jung, Anita

    2011-01-01

    Members of the BAR domain protein superfamily are essential elements of cellular traffic. Endophilins are among the best studied BAR domain proteins. They have a prominent function in synaptic vesicle endocytosis (SVE), receptor trafficking and apoptosis, and in other processes that require...

  17. NAC transcription factors: structurally distinct, functionally diverse

    DEFF Research Database (Denmark)

    Olsen, Addie Nina; Ernst, Heidi A; Leggio, Leila Lo;

    2005-01-01

    NAC proteins constitute one of the largest families of plant-specific transcription factors, and the family is present in a wide range of land plants. Here, we summarize the biological and molecular functions of the NAC family, paying particular attention to the intricate regulation of NAC protei...

  18. Orbitofrontal cortex function and structure in depression.

    Science.gov (United States)

    Drevets, Wayne C

    2007-12-01

    The orbitofrontal cortex (OFC) has been implicated in the pathophysiology of major depression by evidence obtained using neuroimaging, neuropathologic, and lesion analysis techniques. The abnormalities revealed by these techniques show a regional specificity, and suggest that some OFC regions which appear cytoarchitectonically distinct also are functionally distinct with respect to mood regulation. For example, the severity of depression correlates inversely with physiological activity in parts of the posterior lateral and medial OFC, consistent with evidence that dysfunction of the OFC associated with cerebrovascular lesions increases the vulnerability for developing the major depressive syndrome. The posterior lateral and medial OFC function may also be impaired in individuals who develop primary mood disorders, as these patients show grey-matter volumetric reductions, histopathologic abnormalities, and altered hemodynamic responses to emotionally valenced stimuli, probabilistic reversal learning, and reward processing. In contrast, physiological activity in the anteromedial OFC situated in the ventromedial frontal polar cortex increases during the depressed versus the remitted phases of major depressive disorder to an extent that is positively correlated with the severity of depression. Effective antidepressant treatment is associated with a reduction in activity in this region. Taken together these data are compatible with evidence from studies in experimental animals indicating that some orbitofrontal and medial prefrontal cortex regions function to inhibit, while others function to enhance, emotional expression. Alterations in the functional balance between these regions and the circuits they form with anatomically related areas of the temporal lobe, striatum, thalamus, and brain stem thus may underlie the pathophysiology of mood disorders, such as major depression.

  19. Animal Structures and Functions, Science (Experimental): 5314.13.

    Science.gov (United States)

    Silver, Barbara A.

    This unit of instruction was designed to introduce the student to the relationship between structure and function in the animal kingdom, with emphasis given to: (1) the evolution of physiological systems in the major animal phyla, (2) the complementarity of structure and function, and (3) the concept of homeostasis. The booklet lists the relevant…

  20. Studying Membrane Protein Structure and Function Using Nanodiscs

    DEFF Research Database (Denmark)

    Huda, Pie

    The structure and dynamic of membrane proteins can provide valuable information about general functions, diseases and effects of various drugs. Studying membrane proteins are a challenge as an amphiphilic environment is necessary to stabilise the protein in a functionally and structurally relevan...

  1. Structure-function clustering in multiplex brain networks

    Science.gov (United States)

    Crofts, J. J.; Forrester, M.; O'Dea, R. D.

    2016-10-01

    A key question in neuroscience is to understand how a rich functional repertoire of brain activity arises within relatively static networks of structurally connected neural populations: elucidating the subtle interactions between evoked “functional connectivity” and the underlying “structural connectivity” has the potential to address this. These structural-functional networks (and neural networks more generally) are more naturally described using a multilayer or multiplex network approach, in favour of standard single-layer network analyses that are more typically applied to such systems. In this letter, we address such issues by exploring important structure-function relations in the Macaque cortical network by modelling it as a duplex network that comprises an anatomical layer, describing the known (macro-scale) network topology of the Macaque monkey, and a functional layer derived from simulated neural activity. We investigate and characterize correlations between structural and functional layers, as system parameters controlling simulated neural activity are varied, by employing recently described multiplex network measures. Moreover, we propose a novel measure of multiplex structure-function clustering which allows us to investigate the emergence of functional connections that are distinct from the underlying cortical structure, and to highlight the dependence of multiplex structure on the neural dynamical regime.

  2. Small-x asymptotics of structure function $g_2$

    CERN Document Server

    Ermolaev, B I

    1997-01-01

    Nonsinglet structure function g_2(x) for deep inelastic scattering of a lepton on a constituent quark is calculated in the double logarithmic approximation at x<<1. Small-x asymptotics of g_2 is shown to have the same singular behaviour as asymptotics of the nonsinglet structure function g_1.

  3. Small is beautiful... or not?

    NARCIS (Netherlands)

    N. Verhagen

    2005-01-01

    This paper explores recent developments within library organisations and their impact for the functioning of university libraries, and more specific, the relations between the central library and decentral libraries. Examples are taken from the University of Amsterdam, the author's home institution,

  4. ''Beauty of Wholeness and Beauty of Partiality.'' New Terms Defining the Concept of Beauty in Architecture in Terms of Sustainability and Computer Aided Design

    Science.gov (United States)

    Farid, Ayman A.; Zaghloul, Weaam M.; Dewidar, Khaled M.

    2014-01-01

    The great shift in sustainability and computer aided design in the field of architecture caused a remarkable change in the architecture philosophy, new aspects of beauty and aesthetic values are being introduced, and traditional definitions for beauty cannot fully cover this aspects, which causes a gap between; new architecture works criticism and…

  5. Nuclear matrix - structure, function and pathogenesis.

    Science.gov (United States)

    Wasąg, Piotr; Lenartowski, Robert

    2016-12-20

    The nuclear matrix (NM), or nuclear skeleton, is the non-chromatin, ribonucleoproteinaceous framework that is resistant to high ionic strength buffers, nonionic detergents, and nucleolytic enzymes. The NM fulfills a structural role in eukaryotic cells and is responsible for maintaining the shape of the nucleus and the spatial organization of chromatin. Moreover, the NM participates in several cellular processes, such as DNA replication/repair, gene expression, RNA transport, cell signaling and differentiation, cell cycle regulation, apoptosis and carcinogenesis. Short nucleotide sequences called scaffold/matrix attachment regions (S/MAR) anchor the chromatin loops to the NM proteins (NMP). The NMP composition is dynamic and depends on the cell type and differentiation stage or metabolic activity. Alterations in the NMP composition affect anchoring of the S/MARs and thus alter gene expression. This review aims to systematize information about the skeletal structure of the nucleus, with particular emphasis on the organization of the NM and its role in selected cellular processes. We also discuss several diseases that are caused by aberrant NM structure or dysfunction of individual NM elements.

  6. Brain Structure-function Couplings (FY11)

    Science.gov (United States)

    2012-01-01

    following have been generated: • Refereed Journal Papers: 1. Lau, T. M.; Gwin, J. T.; McDowell, K.; Ferris, D. P. Weighted Phase Lag Index Stability as an...Environments 3.1 Authors The authors on this project are Scott Kerick from ARL/HRED, Manuel Vindiola from Dynamics Research Corporation ( DRC ), and Kaleb...Project 3: Validating Functional Connectivity Measures Using Neural Mass Models 4.1 Authors The authors on this project are Manuel Vindiola from DRC

  7. Structures and Functions of Selective Attention.

    Science.gov (United States)

    1987-07-20

    range of adjacent locations (Downing & Pinker , 1985, Rizzolatti, Riggio, Dascola, & Umilta, 1987). The size of the area facilitated depends in part on...increasing with eccentricity from the fovea, with an inhibition stronger once one has crossed the midline (Downing & Pinker , 1985). These disputes indicate...0014-86-0289 and by the McDonnell Center for Higher Brain Function. I am grateful to Drs. Mary K. Rothbart, Steven E. Petersen and Jennifer Sandson

  8. Galactosaminoglycan Function and Oligosaccharide Structure Determination

    Directory of Open Access Journals (Sweden)

    Daniela G. Seidler

    2007-01-01

    Full Text Available This review will discuss the importance of sequencing long chondroitin sulfate and dermatan sulfate chains specifically derived from decorin. Decorin is a member of the small leucine-rich repeat proteoglycans and ubiquitously expressed primarily in the skin. Sequence information and diverse function of glycosaminoglycans is further influenced by variable expression through the core protein indicating the importance to analyse glycosaminoglycans from specific proteoglycans.

  9. An inertial range length scale in structure functions

    CERN Document Server

    Kerr, R M; Gotoh, T; Kerr, Robert M.; Meneguzzi, Maurice; Gotoh, Toshiyuki

    2000-01-01

    It is shown using experimental and numerical data that within the traditional inertial subrange defined by where the third order structure function is linear that the higher order structure function scaling exponents for longitudinal and transverse structure functions converge only over larger scales, $r>r_S$, where $r_S$ has scaling intermediate between $\\eta$ and $\\lambda$ as a function of $R_\\lambda$. Below these scales, scaling exponents cannot be determined for any of the structure functions without resorting to procedures such as extended self-similarity (ESS). With ESS, different longitudinal and transverse higher order exponents are obtained that are consistent with earlier results. The relationship of these statistics to derivative and pressure statistics, to turbulent structures and to length scales is discussed.

  10. Three Kinds of Velocity Structure Function in Turbulent Flows

    Institute of Scientific and Technical Information of China (English)

    LIU Wei; JIANG Nan

    2004-01-01

    Based on the local multi-scale eddy structures in turbulent flows, we elucidate the essential difference between the real turbulent field with a finite Reynolds number and the Kolmogorov fully developed random field. The motion of fluid particles in the real turbulent field is not fully random. There exist multi-scale structures due to the effect of viscosity. Actually the movements of fluid particles in the turbulent field are restricted by such eddy structures. Furthermore, concept of the locally averaged velocity structure function is put forward to describe the relative strain distortion of two adjacent turbulent eddy structures at a certain scale. The time sequence of the longitudinal velocity component at different vertical locations in turbulent boundary layer has been elaborately measured by the constant temperature anemometry of model IFA-300 in a wind tunnel. The experiment proves that the locally averaged velocity structure function is in agreement with the wavelet-coefficient structure function.

  11. Turner syndrome: neuroimaging findings: structural and functional.

    LENUS (Irish Health Repository)

    Mullaney, Ronan

    2009-01-01

    Neuroimaging studies of Turner syndrome can advance our understanding of the X chromosome in brain development, and the modulatory influence of endocrine factors. There is increasing evidence from neuroimaging studies that TX individuals have significant differences in the anatomy, function, and metabolism of a number of brain regions; including the parietal lobe; cerebellum, amygdala, hippocampus; and basal ganglia; and perhaps differences in "connectivity" between frontal and parieto-occipital regions. Finally, there is preliminary evidence that genomic imprinting, sex hormones and growth hormone have significant modulatory effects on brain maturation in TS.

  12. The Structure of Optimum Interpolation Functions.

    Science.gov (United States)

    1983-02-01

    Daniel F . Merriam, ed., Plenum Press, 1970. 2. Hiroshi Akima, "Comments on ’Optimal Contour Mapping Using Universal Kriging’ by Ricardo 0. Olea," (with...Interpolation Scheme," Monthly WeatherReview 109 (1981), 701-721. 22. A. Marechal and J. Serra, "Random Kriging,"pp. 91-112 in Geostatistics, Daniel F . Merriam...ed., Plenum Press, 1970. 23. G. Matheron, "Random Functions and Their Applications in Geology," pp. 79-87 in Geostatistics, Daniel F . Merriam

  13. Fitting EMC structure functions with intrinsic charm

    CERN Document Server

    Rottoli, Luca

    2016-01-01

    A detailed study of the impact of the data collected by the European Muon Collaboration (EMC) on the parton distribution function (PDF) of the charm quark is presented. The analysis is performed in the NNPDF framework, and the charm PDF is freely parametrized on equal footing as light quark and gluon distributions. We find that variations in the treatment of EMC data do not modify the charm PDF and do not affect our previous conclusion on the presence of an intrinsic component in the charm PDF.

  14. Cognitive Adequacy in Structural-Functional Theories of Language

    Science.gov (United States)

    Butler, Christopher S.

    2008-01-01

    This paper discusses the role played by cognition in three linguistic theories which may be labelled as "structural-functional": Functional (Discourse) Grammar, Role and Reference Grammar and Systemic Functional Grammar. It argues that if we are to achieve true cognitive adequacy, we must go well beyond the grammar itself to include the processes…

  15. Hsp70 Structure, Function, Regulation and Influence on Yeast Prions

    OpenAIRE

    D. Sharma; Masison, D. C.

    2009-01-01

    Heat shock proteins protect cells from various conditions of stress. Hsp70, the most ubiquitous and highly conserved Hsp, helps proteins adopt native conformation or regain function after misfolding. Various co-chaperones specify Hsp70 function and broaden its substrate range. We discuss Hsp70 structure and function, regulation by co-factors and influence on propagation of yeast prions.

  16. Structural and functional analysis of rice genome

    Indian Academy of Sciences (India)

    Akhilesh K. Tyagi; Jitendra P. Khurana; Paramjit Khurana; Saurabh Raghuvanshi; Anupama Gaur; Anita Kapur; Vikrant Gupta; Dibyendu Kumar; V. Ravi; Shubha Vij; Parul Khurana; Sulabha Sharma

    2004-04-01

    Rice is an excellent system for plant genomics as it represents a modest size genome of 430 Mb. It feeds more than half the population of the world. Draft sequences of the rice genome, derived by whole-genome shotgun approach at relatively low coverage (4–6 X), were published and the International Rice Genome Sequencing Project (IRGSP) declared high quality (>10 X), genetically anchored, phase 2 level sequence in 2002. In addition, phase 3 level finished sequence of chromosomes 1, 4 and 10 (out of 12 chromosomes of rice) has already been reported by scientists from IRGSP consortium. Various estimates of genes in rice place the number at > 50,000. Already, over 28,000 full-length cDNAs have been sequenced, most of which map to genetically anchored genome sequence. Such information is very useful in revealing novel features of macro- and micro-level synteny of rice genome with other cereals. Microarray analysis is unraveling the identity of rice genes expressing in temporal and spatial manner and should help target candidate genes useful for improving traits of agronomic importance. Simultaneously, functional analysis of rice genome has been initiated by marker-based characterization of useful genes and employing functional knock-outs created by mutation or gene tagging. Integration of this enormous information is expected to catalyze tremendous activity on basic and applied aspects of rice genomics.

  17. Piezo channels: from structure to function.

    Science.gov (United States)

    Volkers, Linda; Mechioukhi, Yasmine; Coste, Bertrand

    2015-01-01

    Mechanotransduction is the conversion of mechanical stimuli into biological signals. It is involved in the modulation of diverse cellular functions such as migration, proliferation, differentiation, and apoptosis as well as in the detection of sensory stimuli such as air vibration and mechanical contact. Therefore, mechanotransduction is crucial for organ development and homeostasis and plays a direct role in hearing, touch, proprioception, and pain. Multiple molecular players involved in mechanotransduction have been identified in the past, among them ion channels directly activated by cell membrane deformation. Most of these channels have well-established roles in lower organisms but are not conserved in mammals or fail to encode mechanically activated channels in mammals due to non-conservation of mechanotransduction property. A family of mechanically activated channels that counts only two members in human, piezo1 and 2, has emerged recently. Given the lack of valid mechanically activated channel candidates in mammals in the past decades, particular attention is given to piezo channels and their potential roles in various biological functions. This review summarizes our current knowledge on these ion channels.

  18. The Most Beautiful Heart%最美丽的心

    Institute of Scientific and Technical Information of China (English)

    章纯

    2010-01-01

    @@ One day a young man was standing in the middle of the town proclaiming that he had the most beautiful heart in the whole valley.A large crowd gathered and they all admired his heart for it was perfect.There was not a mark or a flaw in it.Yes,they all agreed it truly was the most beautiful heart they had ever seen.The young man was very proud and boasted1 more loudly about his beautiful heart.

  19. The RFC clamp loader: structure and function.

    Science.gov (United States)

    Yao, Nina Y; O'Donnell, Mike

    2012-01-01

    The eukaryotic RFC clamp loader couples the energy of ATP hydrolysis to open and close the circular PCNA sliding clamp onto primed sites for use by DNA polymerases and repair factors. Structural studies reveal clamp loaders to be heteropentamers. Each subunit contains a region of homology to AAA+ proteins that defines two domains. The AAA+ domains form a right-handed spiral upon binding ATP. This spiral arrangement generates a DNA binding site within the center of RFC. DNA enters the central chamber through a gap between the AAA+ domains of two subunits. Specificity for a primed template junction is achieved by a third domain that blocks DNA, forcing it to bend sharply. Thus only DNA with a flexible joint can bind the central chamber. DNA entry also requires a slot in the PCNA clamp, which is opened upon binding the AAA+ domains of the clamp loader. ATP hydrolysis enables clamp closing and ejection of RFC, completing the clamp loading reaction.

  20. The structures and functions of oligosaccharins

    Energy Technology Data Exchange (ETDEWEB)

    Albersheim, P.

    1991-08-01

    This document contains a summary of proposed research studying the role of oligosaccharins in developmental biology and in plant-microbe interactions. Research is described in the following areas of developmental biology: Use of the tobacco thin-cell-layer explant bioassay to screen for oligosaccharins that are able to regulate growth and morphogenesis; oligosaccharin receptors - searching for the receptor for biologically active alpha-1,4-oligogalacturnoides; molecular biology studies of endopolygalacturonase in tobacco tissues; investigation of membrane responses induced by oligogalacturonides; the effect of structurally defined oligosaccharins on plant gene expression. In the area of plant-microbe interactions research is focused on: do oligosaccharins elicit the hypersensitive resistance response, and the polygalacturonase-inhibitor protein (PGIP).

  1. [Structure and function of fungal cell wall].

    Science.gov (United States)

    Ohno, Naohito

    2008-12-01

    Cell wall glycans of fungi/yeasts are reviewed. Fungi/yeasts produce various kinds of polysaccharides. As part of the cell wall they are interlinked with other components forming a huge network. The insolubility and complex with multiple components makes the research very tough. Studies on beta-glucan have been performed from various views, such as chemistry, conformation, solubility, tissue distribution and metabolism, biological activity, clinical application, receptor, biosynthesis, and antibody. Studies on mannan focus on immunotoxicity, such as anaphylactoid reaction and coronary arteritis induction. alpha-glucan, chitin, and capsular polysaccharide were also mentioned in relation to structure and genes. Compared with human and animal polysaccharides, fungi/yeasts polysaccharides have very characteristic properties.

  2. History, structure, and function of the Internet.

    Science.gov (United States)

    Glowniak, J

    1998-04-01

    The Internet stands at the forefront of telecommunications in medicine. This worldwide system of computers had its beginnings in networking projects in the United States and western Europe in the 1960s and 1970s. The precursor of the Internet was ARPANET, a long-distance telecommunication network funded by the Department of Defense that linked together computers throughout the United States. In the 1980s, ARPANET was superseded by NSFNET, a series of networks created by the National Science Foundation, which established the present-day structure of the Internet. The physical structure of the Internet resembles and is integrated with the telephone system. Long-distance data transport services are provided by large telecommunication companies, called network service providers (NSPs), through high-capacity, high-speed national and international fiber optic cables. These transport services are accessed through Internet service providers, ISPs. ISPs, the equivalent of regional Bell operating companies, provide the physical link to the NSPs for individuals and organizations. Telecommunications on the Internet are standardized by a set of communications protocols, the TCP/IP protocol suite, that describe routing of messages over the Internet, computer naming conventions, and commonly used Internet services such as e-mail. At present, the Internet consists of over 20 million computer worldwide and is continuing to grow at a rapid rate. Along with the growth of the Internet, higher speed access methods are offering a range of new services such as real-time video and voice communications. Medical education, teaching, and research, as well as clinical practice, will be affected in numerous different ways by these advances.

  3. Small catalytic RNA: Structure, function and application

    Energy Technology Data Exchange (ETDEWEB)

    Monforte, J.A.

    1991-04-01

    We have utilized a combination of photochemical cross-linking techniques and site-directed mutagenesis to obtain secondary and tertiary structure information for the self-cleaving, self-ligating subsequence of RNA from the negative strand of Satellite Tobacco Ringspot Virus. We have found that the helical regions fold about a hinge to promoting four different possible tertiary interactions, creating a molecular of similar shape to a paperclip. A model suggesting that the ``paperclip`` and ``hammerhead`` RNAs share a similar three dimensional structure is proposed. We have used a self-cleaving RNA molecule related to a subsequence of plant viroids, a ``hammerhead,`` to study the length-dependent folding of RNA produced during transcription by RNA polymerase. We have used this method to determine the length of RNA sequestered within elongating E. coli and T7 RNA polymerase complexes. The data show that for E. coli RNA polymerase 12{plus_minus}1 nucleotides are sequestered within the ternary complex, which is consistent with the presence of an RNA-DNA hybrid within the transcription bubble, as proposed by others. The result for T7 RNA polymerase differs from E. coli RNA polymerase, with only 10{plus_minus}1 nucleotides sequestered within the ternary complex, setting a new upper limit for the minimum RNA-DNA required for a stable elongating complex. Comparisons between E. coli and T7 RNA polymerase are made. The relevance of the results to models or transcription termination, abortive initiation, and initiation to elongation mode transitions are discussed.

  4. Small catalytic RNA: Structure, function and application

    Energy Technology Data Exchange (ETDEWEB)

    Monforte, J.A.

    1991-04-01

    We have utilized a combination of photochemical cross-linking techniques and site-directed mutagenesis to obtain secondary and tertiary structure information for the self-cleaving, self-ligating subsequence of RNA from the negative strand of Satellite Tobacco Ringspot Virus. We have found that the helical regions fold about a hinge to promoting four different possible tertiary interactions, creating a molecular of similar shape to a paperclip. A model suggesting that the paperclip'' and hammerhead'' RNAs share a similar three dimensional structure is proposed. We have used a self-cleaving RNA molecule related to a subsequence of plant viroids, a hammerhead,'' to study the length-dependent folding of RNA produced during transcription by RNA polymerase. We have used this method to determine the length of RNA sequestered within elongating E. coli and T7 RNA polymerase complexes. The data show that for E. coli RNA polymerase 12{plus minus}1 nucleotides are sequestered within the ternary complex, which is consistent with the presence of an RNA-DNA hybrid within the transcription bubble, as proposed by others. The result for T7 RNA polymerase differs from E. coli RNA polymerase, with only 10{plus minus}1 nucleotides sequestered within the ternary complex, setting a new upper limit for the minimum RNA-DNA required for a stable elongating complex. Comparisons between E. coli and T7 RNA polymerase are made. The relevance of the results to models or transcription termination, abortive initiation, and initiation to elongation mode transitions are discussed.

  5. [The vestibular system: from structure to function].

    Science.gov (United States)

    Collard, M

    1994-02-01

    The two vestibular receptors, right and left, hidden in the petrous part of the temporal bone with the cochlear receptors, receive information from angular and linear movements of the head and transform them into a nerve message sent to the nuclei of the brainstem, which are connected directly on the one hand to the oculomotor nuclei, at the origin of the oculovestibular reflex (induction of nystagmus), and on the other hand, to the spinal motor neurons, at the origin of the vestibulospinal reflex. These reflexes are associated with responses to visual and somaesthetic information for maintenance or return to the standing position, which characterises the function of equilibrium. Vertigo and disorders of balance reflect a conflict of information between these two labyrinths, or between the vestibular apparatus and the messages issued by other captors, and sometimes also dysfunction of central nervous system treatment of information or a lesion of the effector motor systems.

  6. Integrated Structural Design Education

    DEFF Research Database (Denmark)

    Bjerregaard Jensen, Lotte; Almegaard, Henrik

    2011-01-01

    In Environmental Impact Assessment (EIA), the environment is broadly defined and includes not only quantifiable aspects, but also social conditions, scenic beauty, traffic, cultural heritage, and commercial development. A successful bridge design must comply with all of these demands according to...... of a project, function well in design teams, and comply with EU EIA demands.......In Environmental Impact Assessment (EIA), the environment is broadly defined and includes not only quantifiable aspects, but also social conditions, scenic beauty, traffic, cultural heritage, and commercial development. A successful bridge design must comply with all of these demands according...... landscaping and structural design. The integrated courses create a setting for learning about the design of large-scale structures and involve geometry, statics, computer simulation, graphical design and landscape architecture. Together, they educate engineers who can take part in the early design phases...

  7. Beauty in abstract paintings: Perceptual contrast and statistical properties

    Directory of Open Access Journals (Sweden)

    Birgit eMallon

    2014-03-01

    Full Text Available In this study, we combined the behavioral and objective approach in the field of empirical aesthetics. First, we studied the perception of beauty by investigating shifts in evaluation on perceived beauty of abstract artworks (Experiment 1. Because the participants showed heterogeneous individual preferences for the paintings, we divided them into seven clusters for the test. The experiment revealed a clear pattern of perceptual contrast. The perceived beauty of abstract paintings increased after exposure to paintings that were rated as less beautiful, and it decreased after exposure to paintings that were rated as more beautiful. Next, we searched for correlations of beauty ratings and perceptual contrast with statistical properties of abstract artworks (Experiment 2. The participants showed significant preferences for certain image properties. These preferences differed between the clusters of participants. Strikingly, next to color measures like hue, saturation, value and lightness, the recently described PHOG self-similarity value seems to be a predictor for aesthetic appreciation of abstract artworks. We speculate that the shift in evaluation in Experiment 1 was, at least in part, based on low-level adaptation to some of the statistical image properties analyzed in Experiment 2. In conclusion, our findings demonstrate that the perception of beauty in abstract artworks is altered after exposure to beautiful or non-beautiful images and correlates with particular image properties, especially color measures and self-similarity.

  8. Beauty in abstract paintings: perceptual contrast and statistical properties.

    Science.gov (United States)

    Mallon, Birgit; Redies, Christoph; Hayn-Leichsenring, Gregor U

    2014-01-01

    In this study, we combined the behavioral and objective approach in the field of empirical aesthetics. First, we studied the perception of beauty by investigating shifts in evaluation on perceived beauty of abstract artworks (Experiment 1). Because the participants showed heterogeneous individual preferences for the paintings, we divided them into seven clusters for the test. The experiment revealed a clear pattern of perceptual contrast. The perceived beauty of abstract paintings increased after exposure to paintings that were rated as less beautiful, and it decreased after exposure to paintings that were rated as more beautiful. Next, we searched for correlations of beauty ratings and perceptual contrast with statistical properties of abstract artworks (Experiment 2). The participants showed significant preferences for particular image properties. These preferences differed between the clusters of participants. Strikingly, next to color measures like hue, saturation, value and lightness, the recently described Pyramid of Histograms of Orientation Gradients (PHOG) self-similarity value seems to be a predictor for aesthetic appreciation of abstract artworks. We speculate that the shift in evaluation in Experiment 1 was, at least in part, based on low-level adaptation to some of the statistical image properties analyzed in Experiment 2. In conclusion, our findings demonstrate that the perception of beauty in abstract artworks is altered after exposure to beautiful or non-beautiful images and correlates with particular image properties, especially color measures and self-similarity.

  9. Beauty in abstract paintings: perceptual contrast and statistical properties

    Science.gov (United States)

    Mallon, Birgit; Redies, Christoph; Hayn-Leichsenring, Gregor U.

    2014-01-01

    In this study, we combined the behavioral and objective approach in the field of empirical aesthetics. First, we studied the perception of beauty by investigating shifts in evaluation on perceived beauty of abstract artworks (Experiment 1). Because the participants showed heterogeneous individual preferences for the paintings, we divided them into seven clusters for the test. The experiment revealed a clear pattern of perceptual contrast. The perceived beauty of abstract paintings increased after exposure to paintings that were rated as less beautiful, and it decreased after exposure to paintings that were rated as more beautiful. Next, we searched for correlations of beauty ratings and perceptual contrast with statistical properties of abstract artworks (Experiment 2). The participants showed significant preferences for particular image properties. These preferences differed between the clusters of participants. Strikingly, next to color measures like hue, saturation, value and lightness, the recently described Pyramid of Histograms of Orientation Gradients (PHOG) self-similarity value seems to be a predictor for aesthetic appreciation of abstract artworks. We speculate that the shift in evaluation in Experiment 1 was, at least in part, based on low-level adaptation to some of the statistical image properties analyzed in Experiment 2. In conclusion, our findings demonstrate that the perception of beauty in abstract artworks is altered after exposure to beautiful or non-beautiful images and correlates with particular image properties, especially color measures and self-similarity. PMID:24711791

  10. Challenges and Countermeasures for Beautiful Countryside Construction in China

    Directory of Open Access Journals (Sweden)

    LIU Yan-sui

    2015-04-01

    Full Text Available The 18th National Congress of Communist Party of China proposed the goal of building a beautiful China. The key points and difficulties of beautiful China construction lie in countryside. Beautiful countryside construction is an important integral part of the beauty of China. Under the background of rapid urbanization, industrialization and rural transformative development, beautiful countryside construction has a vital practical significance for renovating hollowed villages, improving rural living environment, reconstructing rural space and narrowing rural-urban income gap as well as promoting rural-urban integrated development. However, the construction of China's beautiful countryside is facing many challenges, i.e., population emigration, employment, land use, resource consumption and environmental governance. In this study, the strategies and outlets to solve the beautiful countryside construction problems were put forward based on the objective analysis of challenges and plights faced by beautiful countryside construction. It would provide a theoretical basis for exploring the geographical patterns of rebalancing the man-land relationship from uncoordinated mode. These findings would also provide a scientific decision support for constructing beautiful countryside construction in new period.

  11. BEAUTY, HEALTH AND WELL-BEING WITH COSMETOTEXTILES

    Directory of Open Access Journals (Sweden)

    CRETU Viorica

    2014-05-01

    Full Text Available The concept of cosmetotextiles, as another aspect of new beauty and health marques a growing success. This hybrid fabric, is definite as a textile article that contains a substance that is release sustainable on the human body skin pointed to perfume, change of appearance, maintenance in good condition, protection, or correction of body odors. Cosmetotextiles are created by microencapsulating different substances for body care or health, that are gradually transfer to the skin, by movement, pressure or the effect of the skin’s natural warmth and enzymes. The paper presents some elements regarding to the microencapsulating process (the major components of them general structure, the major advantages compare to usual presentation of cosmetic substances, some of the used active ingredients and them specific cosmetic and health benefits and the new generation of cosmetotextiles that bring together the latest innovations in fiber and textile structures and products. So, one of the manufacturing processes of a cosmetotextile is based on functionalisation of fibers by fixing microcapsules in them structure, resulting fibers as Novorel, Tencel C, Nilit Breeze, Emana, or by the functionalisation of fabrics, so of products made by these fabrics, where microcapsules are fixed on the external surface of the fabric, resulting in revolutionary “fabrics’ treatments” for beauty, health-care and well-being. Among these cosmeto fabrics and products are Sensitive Ultra Light Firming fabric, Sensitive Fabric Body ware, textile fabrics with the revolutionary Quiospheres technology, Doubleskin and different cosmeto-knitted products including specific placed areas with micro encapsulated ingredients, depending on them destinations (slimming, anti-cellulite treatment, corrective effect

  12. Joint Modelling of Structural and Functional Brain Networks

    DEFF Research Database (Denmark)

    Andersen, Kasper Winther; Herlau, Tue; Mørup, Morten

    Functional and structural magnetic resonance imaging have become the most important noninvasive windows to the human brain. A major challenge in the analysis of brain networks is to establish the similarities and dissimilarities between functional and structural connectivity. We formulate a non...... significant structures that are consistently shared across subjects and data splits. This provides an unsupervised approach for modeling of structure-function relations in the brain and provides a general framework for multimodal integration.......-parametric Bayesian network model which allows for joint modelling and integration of multiple networks. We demonstrate the model’s ability to detect vertices that share structure across networks jointly in functional MRI (fMRI) and diffusion MRI (dMRI) data. Using two fMRI and dMRI scans per subject, we establish...

  13. On a useful functional representation of control system structure

    Science.gov (United States)

    Malchow, Harvey L.

    1988-01-01

    An alternative structure for control systems is proposed. The structure is represented by a three-element block diagram and three functional definitions. It is argued that the three functional elements form a canonical set. The set includes the functions description, estimation and control. General overlay of the structure on parallel state and nested-state control systems is discussed. Breakdown of two real nested-state control systems into the proposed functional format is displayed. Application of the process to the mapping of complex control systems R and D efforts is explained with the Mars Rover Sample and Return mission as an example. A previous application of this basic functional structure to Space Station performance requirements organization is discussed.

  14. The 'beauty' of skin neurobiology.

    Science.gov (United States)

    Pincelli, C; Bonté, F

    2003-07-01

    The skin is the most densely innervated organ in the body and there is a close relationship between the skin and the nervous system. Most skin cells express receptors for neuromediators (NM) and skin cells themselves are an important source of NM. In particular, human keratinocytes synthesize neurotrophins and endorphins and express their receptors. In addition to neurotrophic activity, NM are involved in skin homeostasis, trophism and stress responses. NM released from keratinocytes also function in a paracrine fashion on other skin cells, such as Langerhans cells, melanocytes and fibroblasts. We discuss the influence of NM on these cells, which may be involved in major cosmetic problems like ageing, baldness and dyspigmentation. Based on this correlation, it seems reasonable to target neural factors for cosmetic purposes.

  15. Structural properties of prokaryotic promoter regions correlate with functional features.

    Directory of Open Access Journals (Sweden)

    Pieter Meysman

    Full Text Available The structural properties of the DNA molecule are known to play a critical role in transcription. In this paper, the structural profiles of promoter regions were studied within the context of their diversity and their function for eleven prokaryotic species; Escherichia coli, Klebsiella pneumoniae, Salmonella Typhimurium, Pseudomonas auroginosa, Geobacter sulfurreducens Helicobacter pylori, Chlamydophila pneumoniae, Synechocystis sp., Synechoccocus elongates, Bacillus anthracis, and the archaea Sulfolobus solfataricus. The main anchor point for these promoter regions were transcription start sites identified through high-throughput experiments or collected within large curated databases. Prokaryotic promoter regions were found to be less stable and less flexible than the genomic mean across all studied species. However, direct comparison between species revealed differences in their structural profiles that can not solely be explained by the difference in genomic GC content. In addition, comparison with functional data revealed that there are patterns in the promoter structural profiles that can be linked to specific functional loci, such as sigma factor regulation or transcription factor binding. Interestingly, a novel structural element clearly visible near the transcription start site was found in genes associated with essential cellular functions and growth in several species. Our analyses reveals the great diversity in promoter structural profiles both between and within prokaryotic species. We observed relationships between structural diversity and functional features that are interesting prospects for further research to yet uncharacterized functional loci defined by DNA structural properties.

  16. Novel mechanisms that regulate clot structure/function.

    Science.gov (United States)

    Ariëns, Robert A S

    2016-05-01

    The structure and function of the blood clot has been associated with altered risk of thrombosis. Dense fibrin structures with small pores increase the risk of thrombosis, and have major functional consequences by increasing the resistance to fibrinolysis and altering the visco-elastic properties of the clot. However, while the structural changes to the overall fibrin network have been extensively characterised, little is known regarding the intrafibrillar structure of fibrin, the way protofibrils are arranged inside the fibrin fibers and the functional consequences of this. This brief paper aims to review recent findings regarding novel mechanisms that regulate fibrin intrafibrillar structure, including the degree of protofibril packing, their functional consequences, and the effects of FXIII activation on clot structure and thrombosis. It is concluded that fibrin intrafibrillar structure represents a major novel mechanism that influences clot structure and stability. Future studies are required to investigate the role of fibrin intrafibrillar structure in the functional characteristics of the blood clot, and in diseases of bleeding and thrombosis.

  17. Structure/function relationships in cellulolytic enzymes

    Institute of Scientific and Technical Information of China (English)

    Marc Claeyssens

    2004-01-01

    @@ Cellulose and hemicellulose (mostly xylan), together with lignin, are the major polymeric constituents of plant cell walls and from the largest reservoir of fixed carbon in nature. The enzymatic hydrolysis of polymeric substances by extracellular enzymes, such as cellulases, hemicellulases and laccases, is preferred to chemical depolymerisation to avoid the production of toxic by-products and waste that are expensive to treat. The monosaccharides released through enzymatic hydrolysis can subsequently be microbially converted to commercial commodities, such as bio-ethanol (fuel extender) or microbial protein as feed supplements. The individual depolymerisering enzymes used, such as cellulases,xylanases and laccases, also have industrial application in (i) biobleaching in the paper and pulp industry, (ii) improvement of animal feed (poultry and ruminants) digestibility in feed industries, and (iii) dough rheology and bread volume in the baking process, and beer viscosity and filtration velocity during brewing. The cloning of the genes, coding for several xylan degrading enzymes, and their expression in Baker' s yeast (Saccharomyces cerevisiae) and filamentous fungi (Aspergillus species)opened the possibility to study the pure enzymes, without contaminating activity.Trichoderma reesei produces several of these enzymes and detailed information on their specificity,synergies and structure/activity relationships is known. An overview will be presented.

  18. Engineering structure and function using thermoresponsive biopolymers.

    Science.gov (United States)

    Pastuszka, Martha K; MacKay, J Andrew

    2016-01-01

    Self-assembly enables exquisite control at the smallest scale and generates order among macromolecular-building blocks that remain too small to be manipulated individually. Environmental cues, such as heating, can trigger the organization of these materials from individual molecules to multipartixcle assemblies with a variety of compositions and functions. Synthetic as well as biological polymers have been engineered for these purposes; however, biological strategies can offer unparalleled control over the composition of these macromolecular-building blocks. Biologic polymers are macromolecules composed of monomeric units that can be precisely tailored at the genetic level; furthermore, they can often utilize endogenous biodegradation pathways, which may enhance their potential clinical applications. DNA (nucleotides), polysaccharides (carbohydrates), and proteins (amino acids) have all been engineered to self-assemble into nanostructures in response to a change in temperature. This focus article reviews the growing body of literature exploring temperature-dependent nano-assembly of these biological macromolecules, summarizes some of their physical properties, and discusses future directions.

  19. The rhodopsins: structure and function. Introduction

    Science.gov (United States)

    Lanyi, J. K.

    1992-01-01

    Nature makes use of the propensity of retinal for light-dependent double-bond isomerization in a number of systems and in a variety of ways. The common theme for light receptors based on this kind of chemistry is that (1) the retinal is bound in most cases to a small membrane protein via a protonated lysine-retinal Schiff base, (2) the absorption maximum in the visible is tuned to a suitable wavelength largely by electrostatic interaction with polar protein residues, and (3) the light-induced bond rotations and strains in the retinal set off reaction chains during which at least part of the excess free energy acquired is transferred to the protein and causes pK shifts of acidic residues and/or backbone conformational changes. The physiological consequence of the process initiated by absorption of light is either the activation of an information transfer chain (sensory and visual rhodopsins) or energy transduction which drives the electrogenic movement of ions across the membrane (ion-motive rhodopsins). Rhodopsins with these functions occur in bacteria and in higher organisms; from an evolutionary standpoint they are not related to one another. Nevertheless, all of these proteins are remarkably similar and form a distinct family.

  20. Significance tests for functional data with complex dependence structure

    KAUST Repository

    Staicu, Ana-Maria

    2015-01-01

    We propose an L (2)-norm based global testing procedure for the null hypothesis that multiple group mean functions are equal, for functional data with complex dependence structure. Specifically, we consider the setting of functional data with a multilevel structure of the form groups-clusters or subjects-units, where the unit-level profiles are spatially correlated within the cluster, and the cluster-level data are independent. Orthogonal series expansions are used to approximate the group mean functions and the test statistic is estimated using the basis coefficients. The asymptotic null distribution of the test statistic is developed, under mild regularity conditions. To our knowledge this is the first work that studies hypothesis testing, when data have such complex multilevel functional and spatial structure. Two small-sample alternatives, including a novel block bootstrap for functional data, are proposed, and their performance is examined in simulation studies. The paper concludes with an illustration of a motivating experiment.

  1. Discrete cortical regions associated with the musical beauty of major and minor chords.

    Science.gov (United States)

    Suzuki, Miho; Okamura, Nobuyuki; Kawachi, Yousuke; Tashiro, Manabu; Arao, Hiroshi; Hoshishiba, Takayuki; Gyoba, Jiro; Yanai, Kazuhiko

    2008-06-01

    Previous research has demonstrated that the degree of aesthetic pleasure a person experiences correlates with the activation of reward functions in the brain. However, it is unclear whether different affective qualities and the perceptions of beauty that they evoke correspond to specific areas of brain activation. Major and minor musical keys induce two types of affective qualities--bright/happy and dark/sad--that both evoke aesthetic pleasure. In the present study, we used positron emission tomography to demonstrate that the two musical keys (major and minor) activate distinct brain areas. Minor consonant chords perceived as beautiful strongly activated the right striatum, which has been assumed to play an important role in reward and emotion processing, whereas major consonant chords perceived as beautiful induced significant activity in the left middle temporal gyrus, which is believed to be related to coherent and orderly information processing. These results suggest that major and minor keys, both of which are perceived as beautiful, are processed differently in the brain.

  2. A neurobiological enquiry into the origins of our experience of the sublime and beautiful.

    Science.gov (United States)

    Ishizu, Tomohiro; Zeki, Semir

    2014-01-01

    Philosophies of aesthetics have posited that experience of the sublime-commonly but not exclusively derived from scenes of natural grandeur-is distinct from that of beauty and is a counterpoint to it. We wanted to chart the pattern of brain activity which correlates with the declared intensity of experience of the sublime, and to learn whether it differs from the pattern that correlates with the experience of beauty, reported in our previous studies (e.g., Ishizu and Zeki, 2011). 21 subjects participated in a functional magnetic resonance imaging experiment. Prior to the experiment, they viewed pictures of landscapes, which they rated on a scale of 1-5, with 5 being the most sublime and 1 being the least. This allowed us to select, for each subject, five sets of stimuli-from ones experienced as very sublime to those experienced as not at all sublime-which subjects viewed and re-rated in the scanner while their brain activity was imaged. The results revealed a distinctly different pattern of brain activity from that obtained with the experience of beauty, with none of the areas active with the latter experience also active during experience of the sublime. Sublime and beautiful experiences thus appear to engage separate and distinct brain systems.

  3. Deep inelastic structure functions in the chiral bag model

    Energy Technology Data Exchange (ETDEWEB)

    Sanjose, V. (Valencia Univ. (Spain). Dept. de Didactica de las Ciencias Experimentales); Vento, V. (Valencia Univ. (Spain). Dept. de Fisica Teorica; Centro Mixto CSIC/Valencia Univ., Valencia (Spain). Inst. de Fisica Corpuscular)

    1989-10-02

    We calculate the structure functions for deep inelastic scattering on baryons in the cavity approximation to the chiral bag model. The behavior of these structure functions is analyzed in the Bjorken limit. We conclude that scaling is satisfied, but not Regge behavior. A trivial extension as a parton model can be achieved by introducing the structure function for the pion in a convolution picture. In this extended version of the model not only scaling but also Regge behavior is satisfied. Conclusions are drawn from the comparison of our results with experimental data. (orig.).

  4. A structural biology perspective on NMDA receptor pharmacology and function.

    Science.gov (United States)

    Regan, Michael C; Romero-Hernandez, Annabel; Furukawa, Hiro

    2015-08-01

    N-methyld-aspartate receptors (NMDARs) belong to the large family of ionotropic glutamate receptors (iGluRs), which are critically involved in basic brain functions as well as multiple neurological diseases and disorders. The NMDARs are large heterotetrameric membrane protein complexes. The extensive extracellular domains recognize neurotransmitter ligands and allosteric compounds and translate the binding information to regulate activity of the transmembrane ion channel. Here, we review recent advances in the structural biology of NMDARs with a focus on pharmacology and function. Structural analysis of the isolated extracellular domains in combination with the intact heterotetrameric NMDAR structure provides important insights into how this sophisticated ligand-gated ion channel may function.

  5. Functional substitution of coordination polyhedron in crystal structure of silicates

    Institute of Scientific and Technical Information of China (English)

    叶大年; 马哲生; 赫伟; 李哲; 施倪承; D.Pushcharovsky

    2002-01-01

    On the bases of the study of comparative crystal chemistry of silicates it has been concluded that the octahedra and square pyramids of Ti-0 and Zr-O play functional role of tetrahedra of Si-O in the construction of crystal structures. Therefore, those silicates may be named titano-and zircono-silicates. Because of the functional similarity of coordination polyhedra, the structures of cristobalite and feldspar have been compared with those of perovskite and garnet, respectively. As a new concept, the functional replacement of tetrahedra by octahedra and/or pyramids is defined by the authors of this paper for favorable comparison of relative crystal structures.

  6. Cellular regulation of the structure and function of aortic valves

    Directory of Open Access Journals (Sweden)

    Ismail El-Hamamsy

    2010-01-01

    Full Text Available The aortic valve was long considered a passive structure that opens and closes in response to changes in transvalvular pressure. Recent evidence suggests that the aortic valve performs highly sophisticated functions as a result of its unique microscopic structure. These functions allow it to adapt to its hemodynamic and mechanical environment. Understanding the cellular and molecular mechanisms involved in normal valve physiology is essential to elucidate the mechanisms behind valve disease. We here review the structure and developmental biology of aortic valves; we examine the role of its cellular parts in regulating its function and describe potential pathophysiological and clinical implications.

  7. MODY - calculation of ordered structures by symmetry-adapted functions

    Science.gov (United States)

    Białas, Franciszek; Pytlik, Lucjan; Sikora, Wiesława

    2016-01-01

    In this paper we focus on the new version of computer program MODY for calculations of symmetryadapted functions based on the theory of groups and representations. The choice of such a functional frame of coordinates for description of ordered structures leads to a minimal number of parameters which must be used for presentation of such structures and investigations of their properties. The aim of this work is to find those parameters, which are coefficients of a linear combination of calculated functions, leading to construction of different types of structure ordering with a given symmetry. A spreadsheet script for simplification of this work has been created and attached to the program.

  8. The True Bride: Perceptions of Beauty and Feminine Virtue in Folktales.

    Science.gov (United States)

    Trousdale, Ann

    1989-01-01

    Discusses the quality of the heroines' beauty in several folktales from various cultures. Notes that, unlike Western cultures that equate physical beauty with virtue, in many cultures, beauty is viewed as spiritual and emotional as well as physical. (MM)

  9. Structure-function relationship in novel polyphenolics

    Science.gov (United States)

    Banerjee, Sukanta

    The synthesis, properties and applications of hydroxyaromatic polymers, synthesized enzymatically in AOT/Water/Isooctane water-in-oil microemulsion is the subject of this dissertation. The enzymatic polymerization in such microstructured media furnishes the final polymer product with the unusual morphology of interconnected microspheres. Fundamental characterization of the nature of interaction of a model polymer, poly(4-ethylphenol), with the surfactant AOT, as well as various solvents was carried out to elucidate the molecular mechanism of the morphology development. From an applied perspective, presynthesized poly(4-ethylphenol) was precipitated using AOT/Water/Isooctane water-in-oil microemulsion as the non-solvent to give spherical microparticles. Of specific interest was the encapsulation of macromolecules and nanoparticles initially solubilized in the water droplets by the precipitating polymer matrix. This technique was utilized to synthesize catalytically active and superparamagnetic microspheres, containing entrapped enzyme and nanoparticulate ferrites, respectively. The enzymatically synthesized polymers possess a fully aromatic backbone and hence are expected to have unique pi conjugated structure. On the basis of this hypothesis several conjugated luminescent polymers were synthesized using 2-naphthol and 2,6-dihydroxynaphthalene as the starting monomer. Chemical tuning of the emission properties of these polymers were achieved by copolymerization with 4-ethylphenol which is not a luminescent molecule. Addition of 2,6-dihydroxynaphthalene in dry reversed micellar solutions of AOT induced a dramatic phase transition to a clear luminescent organogel. Hydrogen bonding interaction between the hydroxyl groups and the head group of AOT form the basis of such gels. The microstructure of the gel was probed using NMR and FTIR spectroscopy. Finally, thiol group containing polymers were synthesized to bind nanoparticulate CdS, forming novel photoresponsive

  10. Factor structure of functional state of primary school age children

    Directory of Open Access Journals (Sweden)

    Davidenko O.V.

    2011-02-01

    Full Text Available The examination of primary school children to determine the ranking of significant factors that determine the structure of their functional state depending on the level of physical health. It is shown that the main factor in the structure of the functional state of younger schoolchildren in low-and lower-middle level of physical fitness is selected morpho-functional status, which characterizes the functions of the body at rest. For children with average or above average level of physical fitness is a leading factor in physical fitness of schoolchildren.

  11. Beautiful, but also potentially invasive

    Directory of Open Access Journals (Sweden)

    Lipták Boris

    2015-03-01

    Full Text Available Introduction of non-indigenous exotic species to new areas, where they may establish viable populations and become invasive, is a considerable problem in the protection of nature worldwide, as these species may alter the indigenous species population structure and potentially even decrease the biodiversity. The European fauna underwent through major negative changes on the continent and nowadays, it experiences another new treat, represented by the expanding aquarium pet trade, and with it, associated species (and disease introductions. Exotic freshwater crustaceans are one of the taxa widely incorporated in the business, counting a remarkable number of species. Recent records of the exotic marbled crayfish or Marmorkrebs (Procambarus fallax f. virginalis in German in open ecosystems in Slovakia pointed to human-mediated introductions associated with aquarium pet trade in the country. In this regard, a study of the aquarium pet trade both in expositions and shops and online was assessed. Several crustacean taxa are available both in pet trade exhibitions and online through the Internet. Altogether 26 different species were identified in the aquarium trade in Slovakia. These are Procambarus fallax f. virginalis, P. clarkii, P. alleni, Cherax quadricarinatus, C. destructor, C. holthuisi, C. peknyi, Cambarellus patzcuarensis and C. diminutus occurring in the aquarium pet trade in Slovakia (n = 9. Procambarus fallax f. virginalis, P. clarkii and C. patzuarensis are the most common in this regard. There is also a quantity of other related taxa in the aquarium pet trade in Slovakia, mainly Caridina spp. (n = 5, Neocaridina spp. (n = 4, Atyopsis moluccensis, Atya gabonensis, Arachnochium kulsiense and several taxa of exotic crabs (n = 5 belonging to three different genera (Cardiosoma, Geosesarma and Gecarinus present. Neocaridina davidi is identified as the most frequent in this regard. As some of the species can become established and form viable

  12. Extinction order and altered community structure rapidly disrupt ecosystem functioning.

    Science.gov (United States)

    Larsen, Trond H; Williams, Neal M; Kremen, Claire

    2005-05-01

    By causing extinctions and altering community structure, anthropogenic disturbances can disrupt processes that maintain ecosystem integrity. However, the relationship between community structure and ecosystem functioning in natural systems is poorly understood. Here we show that habitat loss appeared to disrupt ecosystem functioning by affecting extinction order, species richness and abundance. We studied pollination by bees in a mosaic of agricultural and natural habitats in California and dung burial by dung beetles on recently created islands in Venezuela. We found that large-bodied bee and beetle species tended to be both most extinction-prone and most functionally efficient, contributing to rapid functional loss. Simulations confirmed that extinction order led to greater disruption of function than predicted by random species loss. Total abundance declined with richness and also appeared to contribute to loss of function. We demonstrate conceptually and empirically how the non-random response of communities to disturbance can have unexpectedly large functional consequences.

  13. [Beauty judgment: review of the literature].

    Science.gov (United States)

    Faure, Jacques; Bolender, Yves

    2014-03-01

    Esthetic judgments are surely subjective, but as surely, that does not preclude them being studied objectively through rigorous scientific methods. The factual basis of a science of esthetics is not to settle whether some person or image is "objectively beautiful" but rather to determine whether some representative set or sets of individuals judge or experience him/her/it as beautiful or unattractive. The aim of this paper is to review the definitional, theoretical and methodological aspects pertaining to the perception of facial/dental attractiveness by a group of representative individuals. The first part lays down the basic principles of the perception of facial/dental attractiveness: the perception involves a jury, a field of investigation and a test providing quantitative data; the following general determinants of beauty perception are reviewed: the average morphology, the judge's cultural background, the numerology, the judge's ethnical origin. Indirect determinants are the dentition, the osseous architecture and the muscular envelope. Some disruptive factors might alter the judges' facial perception. They might be qualified as either peripheral to the face or psycho-social factors. Peripheral factors include hair style and color, skin hue, wrinkles, lips color... Psycho-social factors cover the personality of the subject being evaluated, his/her intelligence or behavior. The second part deals specifically with the methodology used to determine facial attractiveness and to correlate this latter with a specific morphology. Typically such a study aims to determine average esthetic preferences for some set of visual displays among a particular jury, given a specific task to judge esthetic quality or qualities. The sample being studied, the displays, the jury or jurys, the rating procedure must all be specified prior to collecting data. A specific emphasis will be given to the rating process and the associated morphometrics, the ultimate goal being to

  14. Sleeping Beauty transposon system for genetic etiological research and gene therapy of cancers.

    Science.gov (United States)

    Hou, Xiaomei; Du, Yan; Deng, Yang; Wu, Jianfeng; Cao, Guangwen

    2015-01-01

    Carcinogenesis is etiologically associated with somatic mutations of critical genes. Recently, a number of somatic mutations and key molecules have been found to be involved in functional networks affecting cancer progression. Suitable animal models are required to validate cancer-promoting or -inhibiting capacities of these mutants and molecules. Sleeping Beauty transposon system consists of a transposon that carries gene(s) of interest and a transposase that recognizes, excises, and reinserts genes in given location of the genome. It can create both gain-of-function and loss-of-function mutations, thus being frequently chosen to investigate the etiological mechanisms and gene therapy for cancers in animal models. In this review, we summarized current advances of Sleeping Beauty transposon system in revealing molecular mechanism of cancers and improving gene therapy. Understanding molecular mechanisms by which driver mutations contribute to carcinogenesis and metastasis may pave the way for the development of innovative prophylactic and therapeutic strategies against malignant diseases.

  15. Sleeping Beauty transposon system for genetic etiological research and gene therapy of cancers

    Science.gov (United States)

    Hou, Xiaomei; Du, Yan; Deng, Yang; Wu, Jianfeng; Cao, Guangwen

    2015-01-01

    Carcinogenesis is etiologically associated with somatic mutations of critical genes. Recently, a number of somatic mutations and key molecules have been found to be involved in functional networks affecting cancer progression. Suitable animal models are required to validate cancer-promoting or -inhibiting capacities of these mutants and molecules. Sleeping Beauty transposon system consists of a transposon that carries gene(s) of interest and a transposase that recognizes, excises, and reinserts genes in given location of the genome. It can create both gain-of-function and loss-of-function mutations, thus being frequently chosen to investigate the etiological mechanisms and gene therapy for cancers in animal models. In this review, we summarized current advances of Sleeping Beauty transposon system in revealing molecular mechanism of cancers and improving gene therapy. Understanding molecular mechanisms by which driver mutations contribute to carcinogenesis and metastasis may pave the way for the development of innovative prophylactic and therapeutic strategies against malignant diseases. PMID:25455252

  16. Functional oxide structures on a surface of metals and alloys

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ The investigations of the plasma electrolytic processes in our laboratory are aimed to the development of conditions of formation of oxide layers with determined composition, structure and functional properties on the surface of valve metals (Al, Ti) and their alloys.

  17. Squark Contributions to Photon Structure Functions and Positivity Constraints

    CERN Document Server

    Kitadono, Yoshio; Uematsu, Tsuneo; Yoshida, Yutaka

    2011-01-01

    Photon structure functions in supersymmetric QCD are investigated in terms of the parton model where squark contributions are evaluated. We calculate the eight virtual photon structure functions by taking the discontinuity of the squark massive one-loop diagrams of the photon-photon forward amplitude. The model-independent positivity constraints derived from the Cauchy-Schwarz inequalities are satisfied by the squark parton model calculation and actually the two equality relations hold for the squark contribution. We also show that our polarized photon structure function $g_1^\\gamma$ for the real photon leads to the vanishing 1st moment sum rule, and the constraint $|g_1^\\gamma|\\leq F_1^\\gamma$ is satisfied by the real photon. We also discuss a squark signature in the structure function $W_{TT}^\\tau$.

  18. The nonsinglet structure function evolution by Laplace method

    Energy Technology Data Exchange (ETDEWEB)

    Boroun, G. R., E-mail: grboroun@gmail.com, E-mail: boroun@razi.ac.ir; Zarrin, S. [Razi University, Physics Department (Iran, Islamic Republic of)

    2015-12-15

    We derive a general scheme for the evolution of the nonsinglet structure function at the leadingorder (LO) and next-to-leading-order (NLO) by using the Laplace-transform technique. Results for the nonsinglet structure function are compared with MSTW2008, GRV, and CKMT parameterizations and also EMC experimental data in the LO and NLO analysis. The results are in good agreement with the experimental data and other parameterizations in the low- and large-x regions.

  19. Sleeping Beauty transposon insertional mutagenesis based mouse models for cancer gene discovery

    Science.gov (United States)

    Moriarity, Branden S; Largaespada, David A

    2016-01-01

    Large-scale genomic efforts to study human cancer, such as the cancer gene atlas (TCGA), have identified numerous cancer drivers in a wide variety of tumor types. However, there are limitations to this approach, the mutations and expression or copy number changes that are identified are not always clearly functionally relevant, and only annotated genes and genetic elements are thoroughly queried. The use of complimentary, nonbiased, functional approaches to identify drivers of cancer development and progression is ideal to maximize the rate at which cancer discoveries are achieved. One such approach that has been successful is the use of the Sleeping Beauty (SB) transposon-based mutagenesis system in mice. This system uses a conditionally expressed transposase and mutagenic transposon allele to target mutagenesis to somatic cells of a given tissue in mice to cause random mutations leading to tumor development. Analysis of tumors for transposon common insertion sites (CIS) identifies candidate cancer genes specific to that tumor type. While similar screens have been performed in mice with the PiggyBac (PB) transposon and viral approaches, we limit extensive discussion to SB. Here we discuss the basic structure of these screens, screens that have been performed, methods used to identify CIS. PMID:26051241

  20. Current-mode analog nonlinear function synthesizer structures

    CERN Document Server

    Popa, Cosmin Radu

    2013-01-01

    This book is dedicated to the analysis and design of analog CMOS nonlinear function synthesizer structures, based on original superior-order approximation functions. A variety of analog function synthesizer structures are discussed, based on accurate approximation functions.  Readers will be enabled to implement numerous circuit functions with applications in analog signal processing, including exponential, Gaussian or hyperbolic functions. Generalizing the methods for obtaining these particular functions, the author analyzes superior-order approximation functions, which represent the core for developing CMOS analog nonlinear function synthesizers.   ·         Describes novel methods for generating a multitude of circuit functions, based on superior-order improved accuracy approximation functions; ·         Presents techniques for analog function synthesizers that can be applied easily to a wide variety of analog signal processing circuits; ·         Enables the design of analog s...

  1. Target selection and determination of function in structural genomics.

    Science.gov (United States)

    Watson, James D; Todd, Annabel E; Bray, James; Laskowski, Roman A; Edwards, Aled; Joachimiak, Andrzej; Orengo, Christine A; Thornton, Janet M

    2003-01-01

    The first crucial step in any structural genomics project is the selection and prioritization of target proteins for structure determination. There may be a number of selection criteria to be satisfied, including that the proteins have novel folds, that they be representatives of large families for which no structure is known, and so on. The better the selection at this stage, the greater is the value of the structures obtained at the end of the experimental process. This value can be further enhanced once the protein structures have been solved if the functions of the given proteins can also be determined. Here we describe the methods used at either end of the experimental process: firstly, sensitive sequence comparison techniques for selecting a high-quality list of target proteins, and secondly the various computational methods that can be applied to the eventual 3D structures to determine the most likely biochemical function of the proteins in question.

  2. Automatic structures and growth functions for finitely generated abelian groups

    CERN Document Server

    Kamei, Satoshi

    2011-01-01

    In this paper, we consider the formal power series whose n-th coefficient is the number of copies of a given finite graph in the ball of radius n centred at the identity element in the Cayley graph of a finitely generated group and call it the growth function. Epstein, Iano-Fletcher and Uri Zwick proved that the growth function is a rational function if the group has a geodesic automatic structure. We compute the growth function in the case where the group is abelian and see that the denominator of the rational function is determined from the rank of the group.

  3. Tactile Teaching: Exploring Protein Structure/Function Using Physical Models

    Science.gov (United States)

    Herman, Tim; Morris, Jennifer; Colton, Shannon; Batiza, Ann; Patrick, Michael; Franzen, Margaret; Goodsell, David S.

    2006-01-01

    The technology now exists to construct physical models of proteins based on atomic coordinates of solved structures. We review here our recent experiences in using physical models to teach concepts of protein structure and function at both the high school and the undergraduate levels. At the high school level, physical models are used in a…

  4. On the beauty of nature, paintings and music

    Directory of Open Access Journals (Sweden)

    Ekin Çoraklı

    2014-07-01

    Full Text Available There is a wide range of things that are classified by humans in terms of their level of beauty. The word ‘beautiful’ is used to define some of the natural entities living and nonliving, unnatural objects or ideas produced by humans, and the works of art, which are unique products of human hand and brain. Beauty, as a concept awakening a common feeling of pleasure, may mean something deeper than we are aware of. This meaning is perhaps hidden in its deeper aspects, which we have to give effort to analyze. Hence, within context of this paper, common and specific properties of the beauty of nature, paintings and music will be discussed. In addition, the stages of the perception of the beauty of all kinds will be called into question, and an account about the process of the judgment of beauty will be suggested. The specific types of beauty analyzed through the paper are limited with the beauty of nature, paintings and absolute music (music without words, following an opening remark about the beauty in general.

  5. Gender Differences in the Motivational Processing of Facial Beauty

    Science.gov (United States)

    Levy, Boaz; Ariely, Dan; Mazar, Nina; Chi, Won; Lukas, Scott; Elman, Igor

    2008-01-01

    Gender may be involved in the motivational processing of facial beauty. This study applied a behavioral probe, known to activate brain motivational regions, to healthy heterosexual subjects. Matched samples of men and women were administered two tasks: (a) key pressing to change the viewing time of average or beautiful female or male facial…

  6. Preschoolers' Ideas of What Makes a Picture Book Illustration Beautiful

    Science.gov (United States)

    House, Carolyn A.; Rule, Audrey C.

    2005-01-01

    Preschoolers' reasons for ranking the beauty of 30 children's book illustrations were investigated through individual interviews. Most frequent response criteria for beauty were associated with familiar objects or surroundings, action, color, clothing or accessories, water or ice, body features, and babies or small things. Children's book…

  7. Teaching the Psychology of Engagement with Beauty: State and Trait

    Science.gov (United States)

    Diessner, Rhett; Kirk, Cameron; Guenthner, Crystn; Pohling, Rico; Mobasher, Saman

    2017-01-01

    An undergraduate senior-level course, the psychology of beauty, taught within the positive psychology approach, was designed with the aim to increase state and trait levels of engagement with beauty among its students. The course was a service-learning course in which students were paired by the Area Agency on Aging with elders in the greater…

  8. Network-level structure-function relationships in human neocortex

    NARCIS (Netherlands)

    Miŝic, Bratislav; Betzel, Richard F.; De Reus, Marcel A.; Van Den Heuvel, Martijn P.; Berman, Marc G.; McIntosh, Anthony R.; Sporns, Olaf

    2016-01-01

    The dynamics of spontaneous fluctuations in neural activity are shaped by underlying patterns of anatomical connectivity. While numerous studies have demonstrated edge-wise correspondence between structural and functional connections, much less is known about how large-scale coherent functional netw

  9. Using computational models to relate structural and functional brain connectivity.

    Science.gov (United States)

    Hlinka, Jaroslav; Coombes, Stephen

    2012-07-01

    Modern imaging methods allow a non-invasive assessment of both structural and functional brain connectivity. This has lead to the identification of disease-related alterations affecting functional connectivity. The mechanism of how such alterations in functional connectivity arise in a structured network of interacting neural populations is as yet poorly understood. Here we use a modeling approach to explore the way in which this can arise and to highlight the important role that local population dynamics can have in shaping emergent spatial functional connectivity patterns. The local dynamics for a neural population is taken to be of the Wilson-Cowan type, whilst the structural connectivity patterns used, describing long-range anatomical connections, cover both realistic scenarios (from the CoComac database) and idealized ones that allow for more detailed theoretical study. We have calculated graph-theoretic measures of functional network topology from numerical simulations of model networks. The effect of the form of local dynamics on the observed network state is quantified by examining the correlation between structural and functional connectivity. We document a profound and systematic dependence of the simulated functional connectivity patterns on the parameters controlling the dynamics. Importantly, we show that a weakly coupled oscillator theory explaining these correlations and their variation across parameter space can be developed. This theoretical development provides a novel way to characterize the mechanisms for the breakdown of functional connectivity in diseases through changes in local dynamics.

  10. The ING family tumor suppressors: from structure to function.

    Science.gov (United States)

    Aguissa-Touré, Almass-Houd; Wong, Ronald P C; Li, Gang

    2011-01-01

    The Inhibitor of Growth (ING) proteins belong to a well-conserved family which presents in diverse organisms with several structural and functional domains for each protein. The ING family members are found in association with many cellular processes. Thus, the ING family proteins are involved in regulation of gene transcription, DNA repair, tumorigenesis, apoptosis, cellular senescence and cell cycle arrest. The ING proteins have multiple domains that are potentially capable of binding to many partners. It is conceivable, therefore, that such proteins could function similarly within protein complexes. In this case, within this family, each function could be attributed to a specific domain. However, the role of ING domains is not definitively clear. In this review, we summarize recent advances in structure-function relationships in ING proteins. For each domain, we describe the known biological functions and the approaches utilized to identify the functions associated with ING proteins.

  11. Computing the partition function for kinetically trapped RNA secondary structures.

    Directory of Open Access Journals (Sweden)

    William A Lorenz

    Full Text Available An RNA secondary structure is locally optimal if there is no lower energy structure that can be obtained by the addition or removal of a single base pair, where energy is defined according to the widely accepted Turner nearest neighbor model. Locally optimal structures form kinetic traps, since any evolution away from a locally optimal structure must involve energetically unfavorable folding steps. Here, we present a novel, efficient algorithm to compute the partition function over all locally optimal secondary structures of a given RNA sequence. Our software, RNAlocopt runs in O(n3 time and O(n2 space. Additionally, RNAlocopt samples a user-specified number of structures from the Boltzmann subensemble of all locally optimal structures. We apply RNAlocopt to show that (1 the number of locally optimal structures is far fewer than the total number of structures--indeed, the number of locally optimal structures approximately equal to the square root of the number of all structures, (2 the structural diversity of this subensemble may be either similar to or quite different from the structural diversity of the entire Boltzmann ensemble, a situation that depends on the type of input RNA, (3 the (modified maximum expected accuracy structure, computed by taking into account base pairing frequencies of locally optimal structures, is a more accurate prediction of the native structure than other current thermodynamics-based methods. The software RNAlocopt constitutes a technical breakthrough in our study of the folding landscape for RNA secondary structures. For the first time, locally optimal structures (kinetic traps in the Turner energy model can be rapidly generated for long RNA sequences, previously impossible with methods that involved exhaustive enumeration. Use of locally optimal structure leads to state-of-the-art secondary structure prediction, as benchmarked against methods involving the computation of minimum free energy and of maximum expected

  12. [Function of surface membrane structures in Thiobacillus thiooxidans].

    Science.gov (United States)

    Pivovarova, T A; Karavaĭko, G I

    1975-01-01

    The function of the surface membrane structures was studied with cytochemical techniques on ultrathin sections of Thiobacillus thiooxidans. The transport of elementary sulphur inside the cell involves the surface membrane structures, while oxidation of the sulphur to sulphuric acid takes place on the outer surface of the cytoplasmic membrane. The surface membrane structures are supposed also to participate in the primary dissolution of elementary sulphur at the site of contact of the cells with the mineral.

  13. Spin Structure Functions in a Covariant Spectator Quark Model

    Energy Technology Data Exchange (ETDEWEB)

    G. Ramalho, Franz Gross and M. T. Peña

    2010-12-01

    We apply the covariant spectator quark–diquark model, already probed in the description of the nucleon elastic form factors, to the calculation of the deep inelastic scattering (DIS) spin-independent and spin-dependent structure functions of the nucleon. The nucleon wave function is given by a combination of quark–diquark orbital states, corresponding to S, D and P-waves. A simple form for the quark distribution function associated to the P and D waves is tested.

  14. The end of Sleeping Beauty's nightmare

    CERN Document Server

    Groisman, Berry

    2008-01-01

    The way a rational agent changes her belief in certain propositions/hypotheses in the light of new evidence lies at the heart of Bayesian inference. The basic natural assumption, as summarized in van Fraassen's Reflection Principle ([1984]), would be that in the absence of new evidence the belief should not change. Yet, there are examples that are claimed to violate this assumption. The apparent paradox presented by such examples, if not settled, would demonstrate the inconsistency and/or incompleteness of the Bayesian approach and without eliminating this inconsistency, the approach cannot be regarded as scientific. The Sleeping Beauty Problem is just such an example. The existing attempts to solve the problem fall into three categories. The first two share the view that new evidence is absent, but differ about the conclusion of whether Sleeping Beauty should change her belief or not, and why. The third category is characterized by the view that, after all, new evidence (although hidden from the initial view...

  15. The beauty of the physical world

    CERN Multimedia

    CERN Bulletin

    2010-01-01

    Graham Farmelo, author and former particle physicist, visited CERN on 25 March. To the CERNois gathered in the Main Auditorium, he talked about his new book The Strangest Man, a biography of Paul Dirac. Dirac was obsessed by the importance of mathematical beauty in fundamental physics, a belief that was “almost a religion” to him. Farmelo himself has no doubts: among all of the natural phenomena the LHC may unveil, supersymmetry is the most beautiful.   Talking about the life of a physicist to draw the attention of the public to the science: that was the idea behind Graham Farmelo decision to write a biography of Paul Dirac. The book won the 2009 Costa Biography Award. “I chose Paul Dirac because he was the first truly modern theoretical physicist but he is virtually unknown to the public”, explains Graham Farmelo. “Dirac had a fascinating life. He was not born in a wealthy or a particularly brilliant family but he ended up conceiving in his head ...

  16. SARA: a server for function annotation of RNA structures.

    Science.gov (United States)

    Capriotti, Emidio; Marti-Renom, Marc A

    2009-07-01

    Recent interest in non-coding RNA transcripts has resulted in a rapid increase of deposited RNA structures in the Protein Data Bank. However, a characterization and functional classification of the RNA structure and function space have only been partially addressed. Here, we introduce the SARA program for pair-wise alignment of RNA structures as a web server for structure-based RNA function assignment. The SARA server relies on the SARA program, which aligns two RNA structures based on a unit-vector root-mean-square approach. The likely accuracy of the SARA alignments is assessed by three different P-values estimating the statistical significance of the sequence, secondary structure and tertiary structure identity scores, respectively. Our benchmarks, which relied on a set of 419 RNA structures with known SCOR structural class, indicate that at a negative logarithm of mean P-value higher or equal than 2.5, SARA can assign the correct or a similar SCOR class to 81.4% and 95.3% of the benchmark set, respectively. The SARA server is freely accessible via the World Wide Web at http://sgu.bioinfo.cipf.es/services/SARA/.

  17. Extensions of PDZ domains as important structural and functional elements

    OpenAIRE

    Wang, Conan K.; Pan, Lifeng; Chen, Jia; Zhang, Mingjie

    2010-01-01

    ‘Divide and conquer’ has been the guiding strategy for the study of protein structure and function. Proteins are divided into domains with each domain having a canonical structural definition depending on its type. In this review, we push forward with the interesting observation that many domains have regions outside of their canonical definition that affect their structure and function; we call these regions ‘extensions’. We focus on the highly abundant PDZ (PSD-95, DLG1 and ZO-1) domain. Us...

  18. Matrix Transfer Function Design for Flexible Structures: An Application

    Science.gov (United States)

    Brennan, T. J.; Compito, A. V.; Doran, A. L.; Gustafson, C. L.; Wong, C. L.

    1985-01-01

    The application of matrix transfer function design techniques to the problem of disturbance rejection on a flexible space structure is demonstrated. The design approach is based on parameterizing a class of stabilizing compensators for the plant and formulating the design specifications as a constrained minimization problem in terms of these parameters. The solution yields a matrix transfer function representation of the compensator. A state space realization of the compensator is constructed to investigate performance and stability on the nominal and perturbed models. The application is made to the ACOSSA (Active Control of Space Structures) optical structure.

  19. Proceedings Fourth Workshop on Mathematically Structured Functional Programming

    CERN Document Server

    Chapman, James; 10.4204/EPTCS.76

    2012-01-01

    This volume contains the proceedings of the Fourth Workshop on Mathematically Structured Functional Programming (MSFP 2012), taking place on 25 March, 2012 in Tallinn, Estonia, as a satellite event of the European Joint Conferences on Theory and Practice of Software, ETAPS 2012. MSFP is devoted to the derivation of functionality from structure. It highlights concepts from algebra, semantics and type theory as they are increasingly reflected in programming practice, especially functional programming. The workshop consists of two invited presentations and eight contributed papers on a range of topics at that interface.

  20. Structure and function of the skeletal muscle extracellular matrix.

    Science.gov (United States)

    Gillies, Allison R; Lieber, Richard L

    2011-09-01

    The skeletal muscle extracellular matrix (ECM) plays an important role in muscle fiber force transmission, maintenance, and repair. In both injured and diseased states, ECM adapts dramatically, a property that has clinical manifestations and alters muscle function. Here we review the structure, composition, and mechanical properties of skeletal muscle ECM; describe the cells that contribute to the maintenance of the ECM; and, finally, overview changes that occur with pathology. New scanning electron micrographs of ECM structure are also presented with hypotheses about ECM structure–function relationships. Detailed structure–function relationships of the ECM have yet to be defined and, as a result, we propose areas for future study.

  1. Online Responses to a Multilingual Super Bowl Ad: Is "America the Beautiful" by Any Other Language Still America, the Beautiful?

    Science.gov (United States)

    Hoffman, Brooke Y.

    2016-01-01

    On 2 February 2014, an advertisement entitled "It's Beautiful" debuted during Super Bowl XLVIII, which was watched by 111.5 million people in the USA. The Coca-Cola advertisement portrayed people of various ethnicities and was accompanied by "America the Beautiful" sung in nine languages. Using critical discourse analysis, I…

  2. Rational Design of a Structural and Functional Nitric Oxide Reductase

    Energy Technology Data Exchange (ETDEWEB)

    Yeung, N.; Lin, Y; Gao, Y; Zhao, X; Russell, B; Lei, L; Miner, L; Robinson, H; Lu, Y

    2009-01-01

    Protein design provides a rigorous test of our knowledge about proteins and allows the creation of novel enzymes for biotechnological applications. Whereas progress has been made in designing proteins that mimic native proteins structurally, it is more difficult to design functional proteins. In comparison to recent successes in designing non-metalloproteins, it is even more challenging to rationally design metalloproteins that reproduce both the structure and function of native metalloenzymes. This is because protein metal-binding sites are much more varied than non-metal-containing sites, in terms of different metal ion oxidation states, preferred geometry and metal ion ligand donor sets. Because of their variability, it has been difficult to predict metal-binding site properties in silico, as many of the parameters, such as force fields, are ill-defined. Therefore, the successful design of a structural and functional metalloprotein would greatly advance the field of protein design and our understanding of enzymes. Here we report a successful, rational design of a structural and functional model of a metalloprotein, nitric oxide reductase (NOR), by introducing three histidines and one glutamate, predicted as ligands in the active site of NOR, into the distal pocket of myoglobin. A crystal structure of the designed protein confirms that the minimized computer model contains a haem/non-haem FeB centre that is remarkably similar to that in the crystal structure. This designed protein also exhibits NO reduction activity, and so models both the structure and function of NOR, offering insight that the active site glutamate is required for both iron binding and activity. These results show that structural and functional metalloproteins can be rationally designed in silico.

  3. Electron crystallography for structural and functional studies of membrane proteins.

    Science.gov (United States)

    Fujiyoshi, Yoshinori

    2011-01-01

    Membrane proteins are important research targets for basic biological sciences and drug design, but studies of their structure and function are considered difficult to perform. Studies of membrane structures have been greatly facilitated by technological and instrumental advancements in electron microscopy together with methodological advancements in biology. Electron crystallography is especially useful in studying the structure and function of membrane proteins. Electron crystallography is now an established method of analyzing the structures of membrane proteins in lipid bilayers, which resembles their natural biological environment. To better understand the neural system function from a structural point of view, we developed the cryo-electron microscope with a helium-cooled specimen stage, which allows for analysis of the structures of membrane proteins at a resolution higher than 3 Å. This review introduces recent instrumental advances in cryo-electron microscopy and presents some examples of structure analyses of membrane proteins, such as bacteriorhodopsin, water channels and gap junction channels. This review has two objectives: first, to provide a personal historical background to describe how we came to develop the cryo-electron microscope and second, to discuss some of the technology required for the structural analysis of membrane proteins based on cryo-electron microscopy.

  4. Molecular Structures and Functional Relationships in Clostridial Neurotoxins

    Energy Technology Data Exchange (ETDEWEB)

    Swaminathan S.

    2011-12-01

    The seven serotypes of Clostridium botulinum neurotoxins (A-G) are the deadliest poison known to humans. They share significant sequence homology and hence possess similar structure-function relationships. Botulinum neurotoxins (BoNT) act via a four-step mechanism, viz., binding and internalization to neuronal cells, translocation of the catalytic domain into the cytosol and finally cleavage of one of the three soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNARE) causing blockage of neurotransmitter release leading to flaccid paralysis. Crystal structures of three holotoxins, BoNT/A, B and E, are available to date. Although the individual domains are remarkably similar, their domain organization is different. These structures have helped in correlating the structural and functional domains. This has led to the determination of structures of individual domains and combinations of them. Crystal structures of catalytic domains of all serotypes and several binding domains are now available. The catalytic domains are zinc endopeptidases and share significant sequence and structural homology. The active site architecture and the catalytic mechanism are similar although the binding mode of individual substrates may be different, dictating substrate specificity and peptide cleavage selectivity. Crystal structures of catalytic domains with substrate peptides provide clues to specificity and selectivity unique to BoNTs. Crystal structures of the receptor domain in complex with ganglioside or the protein receptor have provided information about the binding of botulinum neurotoxin to the neuronal cell. An overview of the structure-function relationship correlating the 3D structures with biochemical and biophysical data and how they can be used for structure-based drug discovery is presented here.

  5. Differential Effects of Brain Disorders on Structural and Functional Connectivity

    Science.gov (United States)

    Vega-Pons, Sandro; Olivetti, Emanuele; Avesani, Paolo; Dodero, Luca; Gozzi, Alessandro; Bifone, Angelo

    2017-01-01

    Different measures of brain connectivity can be defined based on neuroimaging read-outs, including structural and functional connectivity. Neurological and psychiatric conditions are often associated with abnormal connectivity, but comparing the effects of the disease on different types of connectivity remains a challenge. In this paper, we address the problem of quantifying the relative effects of brain disease on structural and functional connectivity at a group level. Within the framework of a graph representation of connectivity, we introduce a kernel two-sample test as an effective method to assess the difference between the patients and control group. Moreover, we propose a common representation space for structural and functional connectivity networks, and a novel test statistics to quantitatively assess differential effects of the disease on different types of connectivity. We apply this approach to a dataset from BTBR mice, a murine model of Agenesis of the Corpus Callosum (ACC), a congenital disorder characterized by the absence of the main bundle of fibers connecting the two hemispheres. We used normo-callosal mice (B6) as a comparator. The application of the proposed methods to this data-set shows that the two types of connectivity can be successfully used to discriminate between BTBR and B6, meaning that both types of connectivity are affected by ACC. However, our novel test statistics shows that structural connectivity is significantly more affected than functional connectivity, consistent with the idea that functional connectivity has a robust topology that can tolerate substantial alterations in its structural connectivity substrate. PMID:28119556

  6. The structure function as a metric for roughness and figure

    Science.gov (United States)

    Parks, Robert E.; Tuell, Michael T.

    2016-09-01

    As optical designs become more sophisticated and incorporate aspheric and free form surfaces, the need to specify limits on mid-spatial frequency manufacturing errors becomes more critical, particularly as we better understand the effects of these errors on image quality. While there already exist methods based on Fourier analysis to specify these errors in most commercial interferometry software, the method of calculation and the power spectral density (PSD) results remain obscure to many in the optical design and manufacturing field. We suggest that the structure functions (SF) contains the same information as in the Fourier based PSD but in a way that is much more transparent to analysis, interpretation and application as a specification. The units of measure are more familiar and the concept behind the analysis is simpler to understand. Further, the information contained in the structure function (or PSD) allows a complete specification of an optical surface from the finest measurable detail of roughness to the overall figure. We discuss the origin of the structure function in the field of astronomy to describe the effects of air turbulence on image quality, the simple mathematical definition of the structure function and its easy means of calculation and how its results should be scaled depending on the location of the optical surface in a system from pupil to image plane. Finally, we give an example of how to write a specification of an optical surface using the structure function.

  7. Generating function approach to reliability analysis of structural systems

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    The generating function approach is an important tool for performance assessment in multi-state systems. Aiming at strength reliability analysis of structural systems, generating function approach is introduced and developed. Static reliability models of statically determinate, indeterminate systems and fatigue reliability models are built by constructing special generating functions, which are used to describe probability distributions of strength (resistance), stress (load) and fatigue life, by defining composite operators of generating functions and performance structure functions thereof. When composition operators are executed, computational costs can be reduced by a big margin by means of collecting like terms. The results of theoretical analysis and numerical simulation show that the generating function approach can be widely used for probability modeling of large complex systems with hierarchical structures due to the unified form, compact expression, computer program realizability and high universality. Because the new method considers twin loads giving rise to component failure dependency, it can provide a theoretical reference and act as a powerful tool for static, dynamic reliability analysis in civil engineering structures and mechanical equipment systems with multi-mode damage coupling.

  8. Process-Structure-Function Relations of Pectin in Food.

    Science.gov (United States)

    Christiaens, Stefanie; Van Buggenhout, Sandy; Houben, Ken; Jamsazzadeh Kermani, Zahra; Moelants, Katlijn R N; Ngouémazong, Eugénie D; Van Loey, Ann; Hendrickx, Marc E G

    2016-01-01

    Pectin, a complex polysaccharide rich in galacturonic acid, has been identified as a critical structural component of plant cell walls. The functionality of this intricate macromolecule in fruit- and vegetable-based-derived products and ingredients is strongly determined by the nanostructure of its most abundant polymer, homogalacturonan. During food processing, pectic homogalacturonan is susceptible to various enzymatic as well as nonenzymatic conversion reactions modifying its structural and, hence, its functional properties. Consequently, a profound understanding of the various process-structure-function relations of pectin aids food scientists to tailor the functional properties of plant-based derived products and ingredients. This review describes the current knowledge on process-structure-function relations of pectin in foods with special focus on pectin's functionality with regard to textural attributes of solid plant-based foods and rheological properties of particulated fruit- and vegetable-derived products. In this context, both pectin research performed via traditional, ex situ physicochemical analyses of fractionated walls and isolated polymers and pectin investigation through in situ pectin localization are considered.

  9. Population structure analysis using rare and common functional variants

    Directory of Open Access Journals (Sweden)

    Ding Lili

    2011-11-01

    Full Text Available Abstract Next-generation sequencing technologies now make it possible to genotype and measure hundreds of thousands of rare genetic variations in individuals across the genome. Characterization of high-density genetic variation facilitates control of population genetic structure on a finer scale before large-scale genotyping in disease genetics studies. Population structure is a well-known, prevalent, and important factor in common variant genetic studies, but its relevance in rare variants is unclear. We perform an extensive population structure analysis using common and rare functional variants from the Genetic Analysis Workshop 17 mini-exome sequence. The analysis based on common functional variants required 388 principal components to account for 90% of the variation in population structure. However, an analysis based on rare variants required 532 significant principal components to account for similar levels of variation. Using rare variants, we detected fine-scale substructure beyond the population structure identified using common functional variants. Our results show that the level of population structure embedded in rare variant data is different from the level embedded in common variant data and that correcting for population structure is only as good as the level one wishes to correct.

  10. Adaptation of brain functional and structural networks in aging.

    Science.gov (United States)

    Lee, Annie; Ratnarajah, Nagulan; Tuan, Ta Anh; Chen, Shen-Hsing Annabel; Qiu, Anqi

    2015-01-01

    The human brain, especially the prefrontal cortex (PFC), is functionally and anatomically reorganized in order to adapt to neuronal challenges in aging. This study employed structural MRI, resting-state fMRI (rs-fMRI), and high angular resolution diffusion imaging (HARDI), and examined the functional and structural reorganization of the PFC in aging using a Chinese sample of 173 subjects aged from 21 years and above. We found age-related increases in the structural connectivity between the PFC and posterior brain regions. Such findings were partially mediated by age-related increases in the structural connectivity of the occipital lobe within the posterior brain. Based on our findings, it is thought that the PFC reorganization in aging could be partly due to the adaptation to age-related changes in the structural reorganization of the posterior brain. This thus supports the idea derived from task-based fMRI that the PFC reorganization in aging may be adapted to the need of compensation for resolving less distinctive stimulus information from the posterior brain regions. In addition, we found that the structural connectivity of the PFC with the temporal lobe was fully mediated by the temporal cortical thickness, suggesting that the brain morphology plays an important role in the functional and structural reorganization with aging.

  11. Adaptation of brain functional and structural networks in aging.

    Directory of Open Access Journals (Sweden)

    Annie Lee

    Full Text Available The human brain, especially the prefrontal cortex (PFC, is functionally and anatomically reorganized in order to adapt to neuronal challenges in aging. This study employed structural MRI, resting-state fMRI (rs-fMRI, and high angular resolution diffusion imaging (HARDI, and examined the functional and structural reorganization of the PFC in aging using a Chinese sample of 173 subjects aged from 21 years and above. We found age-related increases in the structural connectivity between the PFC and posterior brain regions. Such findings were partially mediated by age-related increases in the structural connectivity of the occipital lobe within the posterior brain. Based on our findings, it is thought that the PFC reorganization in aging could be partly due to the adaptation to age-related changes in the structural reorganization of the posterior brain. This thus supports the idea derived from task-based fMRI that the PFC reorganization in aging may be adapted to the need of compensation for resolving less distinctive stimulus information from the posterior brain regions. In addition, we found that the structural connectivity of the PFC with the temporal lobe was fully mediated by the temporal cortical thickness, suggesting that the brain morphology plays an important role in the functional and structural reorganization with aging.

  12. Parabolic section and distance excess of space curves applied to protein structure classification

    DEFF Research Database (Denmark)

    Røgen, Peter; Karlsson, Per W.

    2008-01-01

    Proteins are long chain molecules that fold up into beautiful and complicated three-dimensional structures before fulfilling their biological functions in the living organisms. With the aim of providing an efficient tool for describing the proteins' native folds, we present a global geometric mea...

  13. Functional substitution of coordination polyhedron in crystal structure of silicates

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    On the bases of the study of comparative crystal chemistry of silicates it has been concluded that the octahedra and square pyramids of Ti-O and Zr-O play functional role of tetrahedra of Si-O in the construction of crystal structures.Therefore,those silicates may be named titano- and zircono-silicates.Because of the functional similarity of coordination polyhedra,the structures of cristobalite and feldspar have been compared with those of perovskite and garnet,respectively.As a new concept,the functional replacement of tetrahedra by octahedra and/or pyramids is defined by the authors of this paper for favorable comparison of relative crystal structures.

  14. Emerging approaches to probing ion channel structure and function

    Institute of Scientific and Technical Information of China (English)

    Wei-Guang Li; Tian-Le Xu

    2012-01-01

    Ion channels,as membrane proteins,are the sensors of the cell.They act as the first line of communication with the world beyond the plasma membrane and transduce changes in the external and internal environments into unique electrical signals to shape the responses of excitable cells.Because of their importance in cellular communication,ion channels have been intensively studied at the structural and functional levels.Here,we summarize the diverse approaches,including molecular and cellular,chemical,optical,biophysical,and computational,used to probe the structural and functional rearrangements that occur during channel activation (or sensitization),inactivation (or desensitization),and various forms of modulation.The emerging insights into the structure and function of ion channels by multidisciplinary approaches allow the development of new pharmacotherapies as well as new tools useful in controlling cellular activity.

  15. Performance analysis, quality function deployment and structured methods

    Science.gov (United States)

    Maier, M. W.

    Quality function deployment, (QFD), an approach to synthesizing several elements of system modeling and design into a single unit, is presented. Behavioral, physical, and performance modeling are usually considered as separate aspects of system design without explicit linkages. Structured methodologies have developed linkages between behavioral and physical models before, but have not considered the integration of performance models. QFD integrates performance models with traditional structured models. In this method, performance requirements such as cost, weight, and detection range are partitioned into matrices. Partitioning is done by developing a performance model, preferably quantitative, for each requirement. The parameters of the model become the engineering objectives in a QFD analysis and the models are embedded in a spreadsheet version of the traditional QFD matrices. The performance model and its parameters are used to derive part of the functional model by recognizing that a given performance model implies some structure to the functionality of the system.

  16. New insights into plastid nucleoid structure and functionality.

    Science.gov (United States)

    Krupinska, Karin; Melonek, Joanna; Krause, Kirsten

    2013-03-01

    Investigations over many decades have revealed that nucleoids of higher plant plastids are highly dynamic with regard to their number, their structural organization and protein composition. Membrane attachment and environmental cues seem to determine the activity and functionality of the nucleoids and point to a highly regulated structure-function relationship. The heterogeneous composition and the many functions that are seemingly associated with the plastid nucleoids could be related to the high number of chromosomes per plastid. Recent proteomic studies have brought novel nucleoid-associated proteins into the spotlight and indicated that plastid nucleoids are an evolutionary hybrid possessing prokaryotic nucleoid features and eukaryotic (nuclear) chromatin components, several of which are dually targeted to the nucleus and chloroplasts. Future studies need to unravel if and how plastid-nucleus communication depends on nucleoid structure and plastid gene expression.

  17. Intercepts of the non-singlet structure functions

    CERN Document Server

    Ermolaev, B I; Troyan, S I

    2001-01-01

    Infrared evolution equations for small-$x$ behaviour of the non-singlet structure functions $f_1^{NS}$ and $g_1^{NS}$ are obtained and solved in the next-to-leading approximation, to all orders in $\\alpha_s$, and including running $\\alpha_s$ effects. The intercepts of these structure functions, i.e. the exponents of the power-like small-$x$ behaviour, are calculated. A detailed comparison with the leading logarithmic approximation (LLA) and DGLAP is made. We explain why the LLA predictions for the small-$x$ dependence of the structure functions may be more reliable than the prediction for the $Q^2$ dependence in the range of $Q^2$ explored at HERA.

  18. Deuteron Spin Structure Functions at Small Bjorken-x

    CERN Document Server

    Edelmann, J; Weise, W

    1998-01-01

    We investigate polarized deuteron structure functions at small values of the Bjorken variable, x < 0.1. In this region contributions from the coherent interaction of diffractively excited hadronic states with both nucleons become important. A proper treatment of this process requires an extension of the Glauber-Gribov multiple scattering theory to include spin degrees of freedom. In the kinematic domain of current fixed target experiments we observe that shadowing effects in g_1^d are approximately a factor 2-3 larger than for the unpolarized structure function F_2^d. Furthermore the tensor structure function b_1 is found to be surprisingly large at x < 0.1 due to coherent double scattering contributions.

  19. Unified approach to partition functions of RNA secondary structures.

    Science.gov (United States)

    Bundschuh, Ralf

    2014-11-01

    RNA secondary structure formation is a field of considerable biological interest as well as a model system for understanding generic properties of heteropolymer folding. This system is particularly attractive because the partition function and thus all thermodynamic properties of RNA secondary structure ensembles can be calculated numerically in polynomial time for arbitrary sequences and homopolymer models admit analytical solutions. Such solutions for many different aspects of the combinatorics of RNA secondary structure formation share the property that the final solution depends on differences of statistical weights rather than on the weights alone. Here, we present a unified approach to a large class of problems in the field of RNA secondary structure formation. We prove a generic theorem for the calculation of RNA folding partition functions. Then, we show that this approach can be applied to the study of the molten-native transition, denaturation of RNA molecules, as well as to studies of the glass phase of random RNA sequences.

  20. Fractal Beauty in Xinjiang Folk Art Patterns

    Institute of Scientific and Technical Information of China (English)

    PENG Hong; ZHAO Hai-ying

    2014-01-01

    Xinjiang folk art patterns and designs are the art treasures of Chinese cultural treasure-house as well as the precious humanistic resources of Western China. In the process of collecting, sorting out and studying Xinjiang folk art patterns, the elegant simplicity as well as the good taste stands out impressively, and the pattern shape as well as the layout composition shows a distinctive national trait and a strong local color. As “The Geometry of Nature”, fractal geometry brings about a new performing method. Various fractal graphs are created by different generators. Their dynamic pictures contain visual information of great magnitude and their artistic effect is similar to Xinjiang folk art patterns, which fully proves the fractal beauty in Xinjiang folk art patterns.

  1. The 2012 interferometric imaging beauty contest

    Science.gov (United States)

    Baron, Fabien; Cotton, William D.; Lawson, Peter R.; Ridgway, Steve T.; Aarnio, Alicia; Monnier, John D.; Hofmann, Karl-Heinz; Schertl, Dieter; Weigelt, Gerd; Thiébaut, Eric; Soulez, Férréol; Mary, David; Millour, Florentin; Vannier, Martin; Young, John; Elias, Nicholas M.; Schmitt, Henrique R.; Rengaswamy, Sridharan

    2012-07-01

    We present the results of the fifth Interferometric Imaging Beauty Contest. The contest consists in blind imaging of test data sets derived from model sources and distributed in the OIFITS format. Two scenarios of imaging with CHARA/MIRC-6T were offered for reconstruction: imaging a T Tauri disc and imaging a spotted red supergiant. There were eight different teams competing this time: Monnier with the software package MACIM; Hofmann, Schertl and Weigelt with IRS; Thiebaut and Soulez with MiRA ; Young with BSMEM; Mary and Vannier with MIROIRS; Millour and Vannier with independent BSMEM and MiRA entries; Rengaswamy with an original method; and Elias with the radio-astronomy package CASA. The contest model images, the data delivered to the contestants and the rules are described as well as the results of the image reconstruction obtained by each method. These results are discussed as well as the strengths and limitations of each algorithm.

  2. Sex, beauty and the orbitofrontal cortex.

    Science.gov (United States)

    Ishai, Alumit

    2007-02-01

    Face perception is mediated by a distributed neural system in the human brain. Attention, memory and emotion modulate the neural activation evoked by faces, however the effects of gender and sexual orientation are currently unknown. To test whether subjects would respond more to their sexually-preferred faces, we scanned 40 hetero- and homosexual men and women whilst they assessed facial attractiveness. Behaviorally, regardless of their gender and sexual orientation, all subjects similarly rated the attractiveness of both male and female faces. Consistent with our hypothesis, a three-way interaction between stimulus gender, beauty and the sexual preference of the subject was found in the medial orbitofrontal cortex (OFC). In heterosexual women and homosexual men, attractive male faces elicited stronger activation than attractive female faces, whereas in heterosexual men and homosexual women, attractive female faces evoked stronger activation than attractive male faces. These findings suggest that the OFC represents the value of salient sexually-relevant faces, irrespective of their reproductive fitness.

  3. The 2010 Interferometric Imaging Beauty Contest

    CERN Document Server

    Malbet, Fabien; Duvert, Gilles; Lawson, Peter; Chiavassa, Andrea; Young, John; Baron, Fabien; Buscher, David; Rengaswamy, Sridharan; Kloppenborg, Brian; Vannier, Martin; Mugnier, Laurent

    2010-01-01

    We present the results of the fourth Optical/IR Interferometry Imaging Beauty Contest. The contest consists of blind imaging of test data sets derived from model sources and distributed in the OI-FITS format. The test data consists of spectral data sets on an object "observed" in the infrared with spectral resolution. There were 4 different algorithms competing this time: BSMEM the Bispectrum Maximum Entropy Method by Young, Baron & Buscher; RPR the Recursive Phase Reconstruction by Rengaswamy; SQUEEZE a Markov Chain Monte Carlo algorithm by Baron, Monnier & Kloppenborg; and, WISARD the Weak-phase Interferometric Sample Alternating Reconstruction Device by Vannier & Mugnier. The contest model image, the data delivered to the contestants and the rules are described as well as the results of the image reconstruction obtained by each method. These results are discussed as well as the strengths and limitations of each algorithm.

  4. The 2012 Interferometric Imaging Beauty Contest

    CERN Document Server

    Baron, Fabien; Lawson, Peter R; Ridgway, Steve T; Aarnio, Alicia; Monnier, John D; Hofmann, Karl-Heinz; Schertl, Dieter; Weigelt, Gerd; Thiébaut, Eric; Soulez, Férréol; Mary, David; Millour, Florentin; Vannier, Martin; Young, John; Elias, Nicholas M; Schmitt, Henrique R; Rengaswamy, Sridharan

    2012-01-01

    We present the results of the fifth Interferometric Imaging Beauty Contest. The contest consists in blind imaging of test data sets derived from model sources and distributed in the OIFITS format. Two scenarios of imaging with CHARA/MIRC-6T were offered for reconstruction: imaging a T Tauri disc and imaging a spotted red supergiant. There were eight different teams competing this time: Monnier with the software package MACIM; Hofmann, Schertl and Weigelt with IRS; Thi\\'ebaut and Soulez with MiRA ; Young with BSMEM; Mary and Vannier with MIROIRS; Millour and Vannier with independent BSMEM and MiRA entries; Rengaswamy with an original method; and Elias with the radio-astronomy package CASA. The contest model images, the data delivered to the contestants and the rules are described as well as the results of the image reconstruction obtained by each method. These results are discussed as well as the strengths and limitations of each algorithm.

  5. Why Beauty Still Cannot Be Measured

    Directory of Open Access Journals (Sweden)

    Ossi Naukkarinen

    2010-01-01

    Full Text Available This article focuses on the question of whether the latest results achieved in sciences such as evolution studies and brain research can help us understand the nature of aesthetic judgments. It suggests that such approaches may offer interesting insights for understanding many problems in aesthetics, but for clarifying aesthetic judgments one needs a philosophical point of view. Aesthetic judgments cannot be proven right or wrong by scientific methods, and beauty or other aesthetic qualities cannot be directly measured. The “method” of both making and analyzing aesthetic judgments is discussion, and the article clarifies why this is still the case, even if empirical, non-philosophical scientific methods are more accurate than ever before.

  6. Truth and beauty in contemporary urban photography

    Directory of Open Access Journals (Sweden)

    Daniele Colistra

    2014-05-01

    Full Text Available Does city still need photography? Or does it show itself more effectively through other forms of communication? The question brings us back almost two hundred years ago, at the time of the spread of the first daguerreotypes, when the query was: Does city still need painting? The question raises several other issues - truth and beauty, analogical and digital, truth and photo editing - that this essay examines by comparing some images. We are convinced that “the more we can speak of a picture, the more unlikely it is to speak of photography” (R. Barthes. The essay describes the work of some artists/photographers who have addressed the issue of urban photography. Works in which the figurative and visionary component is based on the interaction of traditional shooting techniques and processes of digital post-production.

  7. Defining and identifying Sleeping Beauties in science

    CERN Document Server

    Ke, Qing; Radicchi, Filippo; Flammini, Alessandro

    2015-01-01

    A Sleeping Beauty (SB) in science refers to a paper whose importance is not recognized for several years after publication. Its citation history exhibits a long hibernation period followed by a sudden spike of popularity. Previous studies suggest a relative scarcity of SBs. The reliability of this conclusion is, however, heavily dependent on identification methods based on arbitrary threshold parameters for sleeping time and number of citations, applied to small or monodisciplinary bibliographic datasets. Here we present a systematic, large-scale, and multidisciplinary analysis of the SB phenomenon in science. We introduce a parameter-free measure that quantifies the extent to which a specific paper can be considered an SB. We apply our method to 22 million scientific papers published in all disciplines of natural and social sciences over a time span longer than a century. Our results reveal that the SB phenomenon is not exceptional. There is a continuous spectrum of delayed recognition where both the hiberna...

  8. Optimizing an emperical scoring function for transmembrane protein structure determination.

    Energy Technology Data Exchange (ETDEWEB)

    Young, Malin M.; Sale, Kenneth L.; Gray, Genetha Anne; Kolda, Tamara Gibson

    2003-10-01

    We examine the problem of transmembrane protein structure determination. Like many other questions that arise in biological research, this problem cannot be addressed by traditional laboratory experimentation alone. An approach that integrates experiment and computation is required. We investigate a procedure which states the transmembrane protein structure determination problem as a bound constrained optimization problem using a special empirical scoring function, called Bundler, as the objective function. In this paper, we describe the optimization problem and some of its mathematical properties. We compare and contrast results obtained using two different derivative free optimization algorithms.

  9. Functional and Structural Brain Changes Associated with Methamphetamine Abuse

    Directory of Open Access Journals (Sweden)

    Bruce R. Russell

    2012-10-01

    Full Text Available Methamphetamine (MA is a potent psychostimulant drug whose abuse has become a global epidemic in recent years. Firstly, this review article briefly discusses the epidemiology and clinical pharmacology of methamphetamine dependence. Secondly, the article reviews relevant animal literature modeling methamphetamine dependence and discusses possible mechanisms of methamphetamine-induced neurotoxicity. Thirdly, it provides a critical review of functional and structural neuroimaging studies in human MA abusers; including positron emission tomography (PET and functional and structural magnetic resonance imaging (MRI. The effect of abstinence from methamphetamine, both short- and long-term within the context of these studies is also reviewed.

  10. A measurement of the photon structure function F sub 2

    Energy Technology Data Exchange (ETDEWEB)

    Sasaki, T.; Ishi, Y.; Miyano, K.; Miyata, H. (Niigata Univ. (Japan)); Yamagishi, Y.; Tanaka, R.; Kojima, T.; Matsumoto, S.; Yasuda, T. (Chuo Univ., Tokyo (Japan)); Kirk, P.; Lim, J.; McNeil, R.R.; Metcalf, W.; Myung, S.S. (Louisiana State Univ., Baton Rouge (USA)); Cheng, C.P.; Gu, P.; Ye, M.H.; Zhu, Y.C. (Academia Sinica, Beijing (China). Inst. of High Energy Physics); Abashian, A.; Gotow, K.; Hu, K.P.; Lai, A.Z.; Low, E.H.; Mattson, M.E.; Piilonen, L.; Sterner, K.L. (Virginia Polytechnic Inst. and State Univ., Blacksburg (USA)); Li, Y.K.; Lusin, S.; Rosenfeld, C.; Wang, A.T.M.; Wilson, S. (South Carolina Univ., Columbia (USA)); Frautschi, M.; Kagan, H.; Kass, R. (Ohio State Univ., Columbus (USA)); Breedon, R.E.; Kim, G.N. (California Univ., Davis (USA) National Lab. for High Energy Physics, Tsukuba, Ibaraki (Japan)); Ko, W.; Lander, R.L.; Maeshima, K.; Malchow, R.L.; Rowe, J.; Smith, J.R.; Stuart, D. (California Univ., Davis (USA)); Abe, K.; Fujii, Y.; Higashi, Y.; Kim, S.K.; AMY Collaboration

    1990-12-20

    The photon structure function F{sub 2} has been measured at average Q{sup 2} values of 73, 160 and 390 (GeV/c){sup 2}. We compare the x dependence of the Q{sup 2}=73(GeV/c){sup 2} data with thereotical expectations based on QCD. In addition we present results on the Q{sup 2} evolution of the structure function for the intermediate x range (0.3{le}x{le}0.8). The results are consistent with QCD. (orig.).

  11. [Structure and function of arbuscular mycorrhiza: a review].

    Science.gov (United States)

    Tian, Mi; Chen, Ying-long; Li, Min; Liu, Run-jin

    2013-08-01

    Arbuscular mycorrhiza (AM) is one of the most widely distributed and the most important mutualistic symbionts in terrestrial ecosystems, playing a significant role in enhancing plant resistance to stresses, remediating polluted environments, and maintaining ecosystem stabilization and sustainable productivity. The structural characteristics of AM are the main indicators determining the mycorrhizal formation in root system, and have close relations to the mycorrhizal functions. This paper summarized the structural characteristics of arbuscules, vesicles, mycelia and invasion points of AM, and analyzed the relationships between the Arum (A) type arbuscules, Paris (P) type arbuscules, vesicles, and external mycelia and their functions in improving plant nutrient acquisition and growth, enhancing plant resistance to drought, waterlogging, salinity, high temperature, diseases, heavy metals toxicity, and promoting toxic organic substances decomposition and polluted and degraded soil remediation. The factors affecting the AM structure and functions as well as the action mechanisms of mycorrhizal functions were also discussed. This review would provide a basis for the systemic study of AM structural characteristics and functional mechanisms and for evaluating and screening efficient AM fungal species.

  12. Correlation function as a measure of the structure

    OpenAIRE

    Buryak, O.; Doroshkevich, A.

    1995-01-01

    Geometrical model of structure of the universe is examined to obtain analytical expression for the two points nonlinear correlation function. According to the model the objects (galaxies) are concentrated into two types of structure elements - filaments and sheets. We considered the filaments ( similar to galaxy filaments ) simply as straight lines and the sheets ( similar to superclusters of galaxies ) simply as planes. The homogeneously distributed objects are also taken into consideration....

  13. Density functional theory study on the molecular structure of loganin

    OpenAIRE

    Pandey, Anoop Kumar; Siddiqui, Shamoon Ahmad; Dwivedi, Apoorva; Raj, Kanwal; Misra, Neeraj

    2011-01-01

    The computational Quantum Chemistry (QC) has been used for different types of problems, for example: structural biology, surface phenomena and liquid phase. In this paper we have employed the density functional method for the study of molecular structure of loganin. The equilibrium geometry, harmonic vibrational frequencies and infrared intensities were calculated by B3LYP/6-311G (d, p) method and basis set combinations. It was found that the optimized parameters obtained by the DFT/B3LYP met...

  14. Structure-Function Relationships in Semiconducting Polymers for Organic Photovoltaics

    OpenAIRE

    Kavulak, David Fredric Joel

    2010-01-01

    The major body of this work investigates how the chemical structure of conjugated polymers relates to the fundamental operating mechanism of organic photovoltaic devices. New conjugated polymers were characterized and their optical and electronic properties tested and correlated with their power conversion efficiencies as the active layer in polymer solar cells. From these experiments general structure/function relationships are drawn with an eye toward developing universal guidelines for con...

  15. Silicon Photodetectors Matrix Coordinate Bipolar Functionally Integrated Structures

    Directory of Open Access Journals (Sweden)

    V.N. Murashev

    2015-03-01

    Full Text Available In this paper a new approach for solving the detection and coordinate the detection of radiation in the optical range of 0.3-1.1 microns, based on the use of so-called bipolar functionally integrated structures (BI-FIS in pixels photodetector arrays is discussed. Variants of new technical solutions based on photo-detectors matrix pixel BI-FIS structures are shown. Their effectiveness and scope are evaluated.

  16. The structure and function of bacterial light-harvesting complexes.

    Science.gov (United States)

    Law, Christopher J; Roszak, Aleksander W; Southall, June; Gardiner, Alastair T; Isaacs, Neil W; Cogdell, Richard J

    2004-01-01

    The harvesting of solar radiation by purple photosynthetic bacteria is achieved by circular, integral membrane pigment-protein complexes. There are two main types of light-harvesting complex, termed LH2 and LH1, that function to absorb light energy and to transfer that energy rapidly and efficiently to the photochemical reaction centres where it is trapped. This mini-review describes our present understanding of the structure and function of the purple bacterial light-harvesting complexes.

  17. A no extensive statistical model for the nucleon structure function

    Science.gov (United States)

    Trevisan, Luis A.; Mirez, Carlos

    2013-03-01

    We studied an application of nonextensive thermodynamics to describe the structure function of nucleon, in a model where the usual Fermi-Dirac and Bose-Einstein energy distribution were replaced by the equivalent functions of the q-statistical. The parameters of the model are given by an effective temperature T, the q parameter (from Tsallis statistics), and two chemical potentials given by the corresponding up (u) and down (d) quark normalization in the nucleon.

  18. Quantitative Analysis of the Effective Functional Structure in Yeast Glycolysis

    Science.gov (United States)

    De la Fuente, Ildefonso M.; Cortes, Jesus M.

    2012-01-01

    The understanding of the effective functionality that governs the enzymatic self-organized processes in cellular conditions is a crucial topic in the post-genomic era. In recent studies, Transfer Entropy has been proposed as a rigorous, robust and self-consistent method for the causal quantification of the functional information flow among nonlinear processes. Here, in order to quantify the functional connectivity for the glycolytic enzymes in dissipative conditions we have analyzed different catalytic patterns using the technique of Transfer Entropy. The data were obtained by means of a yeast glycolytic model formed by three delay differential equations where the enzymatic rate equations of the irreversible stages have been explicitly considered. These enzymatic activity functions were previously modeled and tested experimentally by other different groups. The results show the emergence of a new kind of dynamical functional structure, characterized by changing connectivity flows and a metabolic invariant that constrains the activity of the irreversible enzymes. In addition to the classical topological structure characterized by the specific location of enzymes, substrates, products and feedback-regulatory metabolites, an effective functional structure emerges in the modeled glycolytic system, which is dynamical and characterized by notable variations of the functional interactions. The dynamical structure also exhibits a metabolic invariant which constrains the functional attributes of the enzymes. Finally, in accordance with the classical biochemical studies, our numerical analysis reveals in a quantitative manner that the enzyme phosphofructokinase is the key-core of the metabolic system, behaving for all conditions as the main source of the effective causal flows in yeast glycolysis. PMID:22393350

  19. EM vs Weak Structure Functions in DIS processes

    CERN Document Server

    Athar, M Sajjad; Simo, I Ruiz; Vacas, M J Vicente

    2013-01-01

    We obatin the ratio $F_i^A/F_i^{D}$(i=2,3, A=Be, C, Fe, Pb; D=Deuteron) in the case of weak and electromagnetic nuclear structure functions. For this, relativistic nuclear spectral function which incorporate the effects of Fermi motion, binding and nucleon correlations is used. We also consider the pion and rho meson cloud contributions and shadowing and antishadowing effects.

  20. Determination of the pion and kaon structure functions

    Energy Technology Data Exchange (ETDEWEB)

    Aitkenhead, W.; Barton, D.S.; Brandenburg, G.W.; Busza, W.; Dobrowolski, T.; Friedman, J.I.; Kendall, H.W.; Lyons, T.; Nelson, B.; Rosenson, L.; Toy, W.; Verdier, R.; Votta, L.; Chiaradia, M.T.; DeMarzo, C.; Favuzzi, C.; Germinario, G.; Guerriero, L.; LaVopa, P.; Maggi, G.; Posa, F.; Selvaggi, G.; Spinelli, P.; Waldner, F.; Brenner, A.E.; Carey, D.C.; Elias, J.E.; Garbincius, P.H.; Mikenberg, G.; Polychronakos, V.A.; Meunier, R.; Cutts, D.; Dulude, R.S.; Lanou, R.E. Jr.; Massimo, J.T.

    1980-07-21

    Quark structure functions have been extracted from low-p/sub T/ inclusive hadron production data for the pion and kaon with use of the recombination model. n/sup ..pi../=1.0 +- 0.1 and n/sup K/=2.5 +- 0.6 is obtained, where n is the leading (1-x) power of the nonstrange--valence-quark distribution. Both the pion and kaon nonstrange--sea-quark functions have napprox. =3.5.

  1. Study on Dielectric Function Models for Surface Plasmon Resonance Structure

    Directory of Open Access Journals (Sweden)

    Peyman Jahanshahi

    2014-01-01

    Full Text Available The most common permittivity function models are compared and identifying the best model for further studies is desired. For this study, simulations using several different models and an analytical analysis on a practical surface Plasmon structure were done with an accuracy of ∼94.4% with respect to experimental data. Finite element method, combined with dielectric properties extracted from the Brendel-Bormann function model, was utilized, the latter being chosen from a comparative study on four available models.

  2. The impact of structural and functional parameters in glaucoma patients on patient-reported visual functioning.

    Directory of Open Access Journals (Sweden)

    Christoph Hirneiß

    Full Text Available BACKGROUND: To evaluate the impact of structural changes of the retinal nerve fiber layer (RNFL, and visual field loss, on functional impairment assessed by patient-reported visual functioning in glaucoma. METHODS: Patients with glaucomatous optic nerve damage were enrolled in this cross-sectional study. Peripapillary RNFL thickness was obtained with spectral-domain optical coherence tomography (SD-OCT. Function was assessed by patient-reported visual functioning using the Rasch-calibrated Glaucoma Activity Limitation 9 (GAL-9 questionnaire and standard automated perimetry. The impact of peripapillary RNFL loss on functional impairment was analyzed with correlation and linear regression analyses. RESULTS: A total of 176 eyes from 88 glaucoma patients were included. The SD-OCT assessed temporal-superior and temporal-inferior RNFL sector of the worse eye revealed significant correlation with the GAL-9 scores (r=-0.298, p=0.011 and r=-0.251, p=0.033, respectively. In mutivariate regression analysis, the best predictors for patient-reported visual functioning were visual acuity of the better eye and mean defect of the worse eye (R(2=0.334, while structural parameters could not enhance the prediction of GAL-9 scores. CONCLUSIONS: Self-reported visual functioning of patients with glaucoma is better predicted by visual performance data than structural parameters. However, some structural changes of the worse eye are significantly correlated with patient-reported visual functioning.

  3. The impact of structural and functional characteristics of social relations as determinants of functional decline

    DEFF Research Database (Denmark)

    Avlund, Kirsten; Lund, Rikke; Holstein, Bjørn E;

    2004-01-01

    pattern (n = 565); and third, mortality (n = 651). Social relations were measured at baseline by several items focusing on the structure and function of the social network. RESULTS: In men, no weekly telephone contact was related to functional decline and mortality. Among women, less than weekly telephone...

  4. The Appreciation of the Beauty in the Film:The Curious Case of Benjamin Button

    Institute of Scientific and Technical Information of China (English)

    李家妍

    2014-01-01

    This paper appreciates the beauty in the film The Curious Case of Benjamin Buttonfrom three perspectives: technological beauty in visual ef-fects of the film; philosophical beauty in language, which is discussed in characters’monologues and dialogues in the film; and the eternal beauty of love, life and death.

  5. Linking community size structure and ecosystem functioning using metabolic theory.

    Science.gov (United States)

    Yvon-Durocher, Gabriel; Allen, Andrew P

    2012-11-05

    Understanding how biogeochemical cycles relate to the structure of ecological communities is a central research question in ecology. Here we approach this problem by focusing on body size, which is an easily measured species trait that has a pervasive influence on multiple aspects of community structure and ecosystem functioning. We test the predictions of a model derived from metabolic theory using data on ecosystem metabolism and community size structure. These data were collected as part of an aquatic mesocosm experiment that was designed to simulate future environmental warming. Our analyses demonstrate significant linkages between community size structure and ecosystem functioning, and the effects of warming on these links. Specifically, we show that carbon fluxes were significantly influenced by seasonal variation in temperature, and yielded activation energies remarkably similar to those predicted based on the temperature dependencies of individual-level photosynthesis and respiration. We also show that community size structure significantly influenced fluxes of ecosystem respiration and gross primary production, particularly at the annual time-scale. Assessing size structure and the factors that control it, both empirically and theoretically, therefore promises to aid in understanding links between individual organisms and biogeochemical cycles, and in predicting the responses of key ecosystem functions to future environmental change.

  6. Molecular modeling of mechanosensory ion channel structural and functional features.

    Science.gov (United States)

    Gessmann, Renate; Kourtis, Nikos; Petratos, Kyriacos; Tavernarakis, Nektarios

    2010-09-16

    The DEG/ENaC (Degenerin/Epithelial Sodium Channel) protein family comprises related ion channel subunits from all metazoans, including humans. Members of this protein family play roles in several important biological processes such as transduction of mechanical stimuli, sodium re-absorption and blood pressure regulation. Several blocks of amino acid sequence are conserved in DEG/ENaC proteins, but structure/function relations in this channel class are poorly understood. Given the considerable experimental limitations associated with the crystallization of integral membrane proteins, knowledge-based modeling is often the only route towards obtaining reliable structural information. To gain insight into the structural characteristics of DEG/ENaC ion channels, we derived three-dimensional models of MEC-4 and UNC-8, based on the available crystal structures of ASIC1 (Acid Sensing Ion Channel 1). MEC-4 and UNC-8 are two DEG/ENaC family members involved in mechanosensation and proprioception respectively, in the nematode Caenorhabditis elegans. We used these models to examine the structural effects of specific mutations that alter channel function in vivo. The trimeric MEC-4 model provides insight into the mechanism by which gain-of-function mutations cause structural alterations that result in increased channel permeability, which trigger cell degeneration. Our analysis provides an introductory framework to further investigate the multimeric organization of the DEG/ENaC ion channel complex.

  7. Molecular modeling of mechanosensory ion channel structural and functional features.

    Directory of Open Access Journals (Sweden)

    Renate Gessmann

    Full Text Available The DEG/ENaC (Degenerin/Epithelial Sodium Channel protein family comprises related ion channel subunits from all metazoans, including humans. Members of this protein family play roles in several important biological processes such as transduction of mechanical stimuli, sodium re-absorption and blood pressure regulation. Several blocks of amino acid sequence are conserved in DEG/ENaC proteins, but structure/function relations in this channel class are poorly understood. Given the considerable experimental limitations associated with the crystallization of integral membrane proteins, knowledge-based modeling is often the only route towards obtaining reliable structural information. To gain insight into the structural characteristics of DEG/ENaC ion channels, we derived three-dimensional models of MEC-4 and UNC-8, based on the available crystal structures of ASIC1 (Acid Sensing Ion Channel 1. MEC-4 and UNC-8 are two DEG/ENaC family members involved in mechanosensation and proprioception respectively, in the nematode Caenorhabditis elegans. We used these models to examine the structural effects of specific mutations that alter channel function in vivo. The trimeric MEC-4 model provides insight into the mechanism by which gain-of-function mutations cause structural alterations that result in increased channel permeability, which trigger cell degeneration. Our analysis provides an introductory framework to further investigate the multimeric organization of the DEG/ENaC ion channel complex.

  8. Soil-borne microbial functional structure across different land uses.

    Science.gov (United States)

    Kuramae, Eiko E; Zhou, Jizhong Z; Kowalchuk, George A; van Veen, Johannes A

    2014-01-01

    Land use change alters the structure and composition of microbial communities. However, the links between environmental factors and microbial functions are not well understood. Here we interrogated the functional structure of soil microbial communities across different land uses. In a multivariate regression tree analysis of soil physicochemical properties and genes detected by functional microarrays, the main factor that explained the different microbial community functional structures was C : N ratio. C : N ratio showed a significant positive correlation with clay and soil pH. Fields with low C : N ratio had an overrepresentation of genes for carbon degradation, carbon fixation, metal reductase, and organic remediation categories, while fields with high C : N ratio had an overrepresentation of genes encoding dissimilatory sulfate reductase, methane oxidation, nitrification, and nitrogen fixation. The most abundant genes related to carbon degradation comprised bacterial and fungal cellulases; bacterial and fungal chitinases; fungal laccases; and bacterial, fungal, and oomycete polygalacturonases. The high number of genes related to organic remediation was probably driven by high phosphate content, while the high number of genes for nitrification was probably explained by high total nitrogen content. The functional gene diversity found in different soils did not group the sites accordingly to land management. Rather, the soil factors, C : N ratio, phosphate, and total N, were the main factors driving the differences in functional genes across the fields examined.

  9. When We like What We Know--A Parametric fMRI Analysis of Beauty and Familiarity

    Science.gov (United States)

    Bohrn, Isabel C.; Altmann, Ulrike; Lubrich, Oliver; Menninghaus, Winfried; Jacobs, Arthur M.

    2013-01-01

    This paper presents a neuroscientific study of aesthetic judgments on written texts. In an fMRI experiment participants read a number of proverbs without explicitly evaluating them. In a post-scan rating they rated each item for familiarity and beauty. These individual ratings were correlated with the functional data to investigate the neural…

  10. The Effects of Novelty and Familiarity on Beauty Perception

    Directory of Open Access Journals (Sweden)

    Hyejeong Jang

    2011-05-01

    Full Text Available In order to investigate how novelty and familiarity affect beauty perception, fractal images were presented five times over 14 weeks. Fractal images are unfamiliar to people, hence used in this study to control their previous experience. a total of 800 fractal images were divided into five groups (160 images X 5 group, and three groups of images were presented to participants each time for five times. The results showed that while beauty perception is decreased until the third exposure, it is increased from third to fifth exposure. These results suggest that a certain level of repeated exposure is necessary for subjects to become familiar, which in turn affect beauty perception.

  11. Osteoblast functions in functionally graded Ti-6Al-4 V mesh structures.

    Science.gov (United States)

    Nune, K C; Kumar, A; Misra, R D K; Li, S J; Hao, Y L; Yang, R

    2016-03-01

    We describe here the combined efforts of engineering and biological sciences as a systemic approach to fundamentally elucidate osteoblast functions in functionally graded Ti-6Al-4 V mesh structures in relation to uniform/monolithic mesh arrays. First, the interconnecting porous architecture of functionally graded mesh arrays was conducive to cellular functions including attachment, proliferation, and mineralization. The underlying reason is that the graded fabricated structure with cells seeded from the large pore size side provided a channel for efficient transfer of nutrients to other end of the structure (small pore size), leading to the generation of mineralized extracellular matrix by differentiating pre-osteoblasts. Second, a comparative and parametric study indicated that gradient mesh structure had a pronounced effect on cell adhesion and mineralization, and strongly influenced the proliferation phase. High intensity and near-uniform distribution of proteins (actin and vinculin) on struts of the gradient mesh structure (cells seeded from large pore side) implied signal transduction during cell adhesion and was responsible for superior cellular activity, in comparison to the uniform mesh structure and non-porous titanium alloy. Cells adhered to the mesh struts by forming a sheet, bridging the pores through numerous cytoplasmic extensions, in the case of porous mesh structures. Intercellular interaction in porous structures provided a pathway for cells to communicate and mature to a differentiated phenotype. Furthermore, the capability of cells to migrate through the interconnecting porous architecture on mesh structures led to colonization of the entire structure. Cells were embedded layer-by-layer in the extracellular matrix as the matrix mineralized. The outcomes of the study are expected to address challenges associated with the treatment of segmental bone defects and bone-remodeling through favorable modulation of cellular response. Moreover, the study

  12. Lung morphometry: the link between structure and function.

    Science.gov (United States)

    Weibel, Ewald R

    2017-03-01

    The study of the structural basis of gas exchange function in the lung depends on the availability of quantitative information that concerns the structures establishing contact between the air in the alveoli and the blood in the alveolar capillaries, which can be entered into physiological equations for predicting oxygen uptake. This information is provided by morphometric studies involving stereological methods and allows estimates of the pulmonary diffusing capacity of the human lung that agree, in experimental studies, with the maximal oxygen consumption. The basis for this "machine lung" structure lies in the complex design of the cells building an extensive air-blood barrier with minimal cell mass.

  13. Forecasting Urban Forest Ecosystem Structure, Function, and Vulnerability

    Science.gov (United States)

    Steenberg, James W. N.; Millward, Andrew A.; Nowak, David J.; Robinson, Pamela J.; Ellis, Alexis

    2017-03-01

    The benefits derived from urban forest ecosystems are garnering increasing attention in ecological research and municipal planning. However, because of their location in heterogeneous and highly-altered urban landscapes, urban forests are vulnerable and commonly suffer disproportionate and varying levels of stress and disturbance. The objective of this study is to assess and analyze the spatial and temporal changes, and potential vulnerability, of the urban forest resource in Toronto, Canada. This research was conducted using a spatially-explicit, indicator-based assessment of vulnerability and i-Tree Forecast modeling of temporal changes in forest structure and function. Nine scenarios were simulated for 45 years and model output was analyzed at the ecosystem and municipal scale. Substantial mismatches in ecological processes between spatial scales were found, which can translate into unanticipated loss of function and social inequities if not accounted for in planning and management. At the municipal scale, the effects of Asian longhorned beetle and ice storm disturbance were far less influential on structure and function than changes in management actions. The strategic goals of removing invasive species and increasing tree planting resulted in a decline in carbon storage and leaf biomass. Introducing vulnerability parameters in the modeling increased the spatial heterogeneity in structure and function while expanding the disparities of resident access to ecosystem services. There was often a variable and uncertain relationship between vulnerability and ecosystem structure and function. Vulnerability assessment and analysis can provide strategic planning initiatives with valuable insight into the processes of structural and functional change resulting from management intervention.

  14. Boosting beauty in an economic decline: mating, spending, and the lipstick effect.

    Science.gov (United States)

    Hill, Sarah E; Rodeheffer, Christopher D; Griskevicius, Vladas; Durante, Kristina; White, Andrew Edward

    2012-08-01

    Although consumer spending typically declines in economic recessions, some observers have noted that recessions appear to increase women's spending on beauty products--the so-called lipstick effect. Using both historical spending data and rigorous experiments, the authors examine how and why economic recessions influence women's consumer behavior. Findings revealed that recessionary cues--whether naturally occurring or experimentally primed--decreased desire for most products (e.g., electronics, household items). However, these cues consistently increased women's desire for products that increase attractiveness to mates--the first experimental demonstration of the lipstick effect. Additional studies show that this effect is driven by women's desire to attract mates with resources and depends on the perceived mate attraction function served by these products. In addition to showing how and why economic recessions influence women's desire for beauty products, this research provides novel insights into women's mating psychology, consumer behavior, and the relationship between the two.

  15. Structure and function of large-scale brain systems.

    Science.gov (United States)

    Koziol, Leonard F; Barker, Lauren A; Joyce, Arthur W; Hrin, Skip

    2014-01-01

    This article introduces the functional neuroanatomy of large-scale brain systems. Both the structure and functions of these brain networks are presented. All human behavior is the result of interactions within and between these brain systems. This system of brain function completely changes our understanding of how cognition and behavior are organized within the brain, replacing the traditional lesion model. Understanding behavior within the context of brain network interactions has profound implications for modifying abstract constructs such as attention, learning, and memory. These constructs also must be understood within the framework of a paradigm shift, which emphasizes ongoing interactions within a dynamically changing environment.

  16. Structure and regulatory function of plant transcription factors

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The expression of inducible genes in plants is regulated byspecific transcription factors at the transcriptional level. A typical transcription factor usually contains a DNA-binding domain, a transcription regulation domain, a dimerization site and a nuclear localization domain. These functional domains define the characteristic, localization and regulatory role of a transcription factor. Transcription factors recognize and bind to specific cis-acting elements or interact with other proteins, and then activate or repress the transcription of target genes by their functional domains. In recent years, elucidation on the structure and function of transcription factors has become an important subject in plant molecular biology.

  17. Protein mechanics: a route from structure to function

    Indian Academy of Sciences (India)

    Richard Lavery; Sophie Sacquin-Mora

    2007-08-01

    In order to better understand the mechanical properties of proteins, we have developed simulation tools which enable these properties to be analysed on a residue-by-residue basis. Although these calculations are relatively expensive with all-atom protein models, good results can be obtained much faster using coarse-grained approaches. The results show that proteins are surprisingly heterogeneous from a mechanical point of view and that functionally important residues often exhibit unusual mechanical behaviour. This finding offers a novel means for detecting functional sites and also potentially provides a route for understanding the links between structure and function in more general terms.

  18. Improved protein structure selection using decoy-dependent discriminatory functions

    Directory of Open Access Journals (Sweden)

    Levitt Michael

    2004-06-01

    Full Text Available Abstract Background A key component in protein structure prediction is a scoring or discriminatory function that can distinguish near-native conformations from misfolded ones. Various types of scoring functions have been developed to accomplish this goal, but their performance is not adequate to solve the structure selection problem. In addition, there is poor correlation between the scores and the accuracy of the generated conformations. Results We present a simple and nonparametric formula to estimate the accuracy of predicted conformations (or decoys. This scoring function, called the density score function, evaluates decoy conformations by performing an all-against-all Cα RMSD (Root Mean Square Deviation calculation in a given decoy set. We tested the density score function on 83 decoy sets grouped by their generation methods (4state_reduced, fisa, fisa_casp3, lmds, lattice_ssfit, semfold and Rosetta. The density scores have correlations as high as 0.9 with the Cα RMSDs of the decoy conformations, measured relative to the experimental conformation for each decoy. We previously developed a residue-specific all-atom probability discriminatory function (RAPDF, which compiles statistics from a database of experimentally determined conformations, to aid in structure selection. Here, we present a decoy-dependent discriminatory function called self-RAPDF, where we compiled the atom-atom contact probabilities from all the conformations in a decoy set instead of using an ensemble of native conformations, with a weighting scheme based on the density scores. The self-RAPDF has a higher correlation with Cα RMSD than RAPDF for 76/83 decoy sets, and selects better near-native conformations for 62/83 decoy sets. Self-RAPDF may be useful not only for selecting near-native conformations from decoy sets, but also for fold simulations and protein structure refinement. Conclusions Both the density score and the self-RAPDF functions are decoy

  19. Twist decomposition of Drell-Yan structure functions: phenomenological implications

    Science.gov (United States)

    Brzemiński, Dawid; Motyka, Leszek; Sadzikowski, Mariusz; Stebel, Tomasz

    2017-01-01

    The forward Drell-Yan process in pp scattering at the LHC at √{S} = 14 TeV is considered. We analyze the Drell-Yan structure functions assuming the dominance of a Compton-like emission of a virtual photon from a fast quark scattering off the small x gluons. The color dipole framework is applied to perform quantitatively the twist decomposition of all the Drell-Yan structure functions. Two models of the color dipole scattering are applied: the Golec-Biernat-Wüsthoff model and the dipole cross section obtained from the Balitsky-Fadin-Kuraev-Lipatov evolution equation. The two models have essentially different higher twist content and the gluon transverse momentum distribution and lead to different significant effects beyond the collinear leading twist description. It is found that the gluon transverse momentum effects are significant in the Drell-Yan structure functions for all Drell-Yan pair masses M, and the higher twist effects become important for M ≲ 10GeV. It is found that the structure function W TT related to the A 2 angular coefficient and the Lam-Tung observable A 0 - A 2 are particularly sensitive to the gluon k T effects and to the higher twist effects. A procedure is suggested how to disentangle the higher twist effects from the gluon transverse momentum effects.

  20. The Intestinal Tract: Structure, Function, Disorders and Related Medication.

    Science.gov (United States)

    Wagner, Dianne M.

    This instructional guide is intended for use within inservice or continuing education programs for people who work in long-term care facilities. This module includes an overview of the normal functions of the small and large intestines and discusses the structures of the intestines, absorption in the intestines, and commonly occurring conditions…

  1. Structure and function relationship of human heart from DENSE MRI

    Science.gov (United States)

    Moghaddam, Abbas N.; Gharib, Morteza

    2007-03-01

    The study here, suggests a macroscopic structure for the Left Ventricle (LV), based on the heart kinematics which is obtained through imaging. The measurement of the heart muscle deformation using the Displacement ENcoding with Stimulated Echoes (DENSE) MRI, which describes the heart kinematics in the Lagrangian frame work, is used to determine the high resolution patterns of true myocardial strain. Subsequently, the tangential Shortening Index (SI) and the thickening of the LV wall are calculated for each data point. Considering the heart as a positive-displacement pump, the contribution of each segment of LV in the heart function, can be determined by the SI and thickening of the wall in the same portion. Hence the SI isosurfaces show the extent and spatial distribution of the heart activity and reveals its macro structure. The structure and function of the heart are, therefore, related which in turn results in a macroscopic model for the LV. In particular, it was observed that the heart functionality is not uniformly distributed in the LV, and the regions with greater effect on the pumping process, form a band which wraps around the heart. These results, which are supported by the established histological evidence, may be considered as a landmark in connecting the structure and function of the heart through imaging. Furthermore, the compatibility of this model with microscopic observations about the fiber direction is investigated. This method may be used for planning as well as post evaluation of the ventriculoplasty.

  2. Two-level convolution formula for nuclear structure function

    Science.gov (United States)

    Ma, Boqiang

    1990-05-01

    A two-level convolution formula for the nuclear structure function is derived in considering the nucleus as a composite system of baryon-mesons which are also composite systems of quark-gluons again. The results show that the European Muon Colaboration effect can not be explained by the nuclear effects as nucleon Fermi motion and nuclear binding contributions.

  3. Multi-functional Anti-pollution Construction Structure for Drilling

    Institute of Scientific and Technical Information of China (English)

    Chen Lirong; Yin Weidong; Yang Ping; Wang Rong

    1997-01-01

    @@ Treatment of drilling waste water is the focus of environmental protection for the East Sichuan Drilling Corporation. The three-functional (consists of settling pit, oil interceptor,cistern) construction structure against pollution from drilling waste water was preliminarily improved in 1989.

  4. Structural and functional models for [NiFe] hydrogenase

    NARCIS (Netherlands)

    Angamuthu, Raja

    2009-01-01

    The main goal of the research presented in this thesis is the synthesis of suitable structural and functional models for the enzyme [NiFe] hydrogenase, which can reduce protons into dihydrogen. A brief survey of the roles of all the known nickel containing enzymes in biological systems with a focus

  5. THE CRUSTAL STRUCTURE OF ELLESMERE ISLAND FROM RECEIVER FUNCTION MODELLING

    DEFF Research Database (Denmark)

    Schiffer, Christian; Stephenson, Randell Alexander; Oakey, Gordon

    . Preliminary results give estimates of Moho depths and crustal velocity structure and these are discussed with a focus on the relationship to topography, regional geological units and fault zones. The receiver functions reveal crustal roots underneath the Victoria and Albert Mountains (45km) and the Grantland...

  6. Mass-spectrometric exploration of proteome structure and function

    DEFF Research Database (Denmark)

    Aebersold, Ruedi; Mann, Matthias

    2016-01-01

    , the structures and functions of selected proteins have been studied using biochemical and biophysical methods. However, the properties and behaviour of the proteome as an integrated system have largely remained elusive. Powerful mass-spectrometry-based technologies now provide unprecedented insights...

  7. Functional oxide structures on a surface of metals and alloys

    Institute of Scientific and Technical Information of China (English)

    Rudnev; V.; S.; Yarovaya; T.; P.; Boguta; D.; L.; Lukiyanchuk; I.; V.; Tyrina; L.; M.; Morozova; V.; P.; Nedozorov; P.; M.; Vasilyeva; M.; S.; Kondrikov; N.; B.

    2005-01-01

    The investigations of the plasma electrolytic processes in our laboratory are aimed to the development of conditions of formation of oxide layers with determined composition, structure and functional properties on the surface of valve metals (Al, Ti) and their alloys.……

  8. Regarding Chilcott's "Structural Functionalism as a Heuristic Device" Heuristically.

    Science.gov (United States)

    Blot, Richard K.

    1998-01-01

    The heuristic value of Chilcott's essay lies less in its support for structural functionalism and more in its concern to reexamine theory in the work of earlier educational anthropologists for what earlier theories and practices can add to current research. (SLD)

  9. Studies on the structure and function of pyruvate dehydrogenase complexes

    NARCIS (Netherlands)

    Abreu, de R.A.

    1978-01-01

    The aim of the present investigation was to obtain more information of the structure and function of the pyruvate dehydrogenase complexes from Azotobacter vinelandii and Escherichia coli.In chapter 2 a survey is given of the recent literature on pyruvate dehydrogenase complexes.In chapter 3 results

  10. From dynamics to structure and function of model biomolecular systems

    NARCIS (Netherlands)

    Fontaine-Vive-Curtaz, F.

    2007-01-01

    The purpose of this thesis was to extend recent works on structure and dynamics of hydrogen bonded crystals to model biomolecular systems and biological processes. The tools that we have used are neutron scattering (NS) and density functional theory (DFT) and force field (FF) based simulation method

  11. Glucoamylase: structure/function relationships, and protein engineering

    DEFF Research Database (Denmark)

    Sauer, J; Sigurskjold, B W; Christensen, U;

    2000-01-01

    fundamental structure/function relationships in the binding and catalytic mechanisms. In parallel, issues of relevance for application have been pursued using protein engineering to improve the industrial properties. The present review focuses on recent findings on the catalytic site, mechanism of action...

  12. From structure to function : Protein assemblies dissected by mass spectrometry

    NARCIS (Netherlands)

    Lorenzen, K.

    2008-01-01

    This thesis demonstrates some of the possibilities mass spectrometry can provide to gain new insight into structure and function of protein complexes. While technologies in native mass spectrometry are still under development, it already allows research on complete proteins and protein complexes up

  13. The Polarized Structure Function $g_{2} A Lattice Study Revisited

    CERN Document Server

    Göckeler, M; Kürzinger, W; Oelrich, H; Rakow, P; Schierholz, G

    1999-01-01

    A recent lattice calculation of the spin-dependent structure function g_2 is revisited. It has been recognized that the twist-three operator, which gives rise to d_2, mixes non-perturbatively with operators of lower dimensions under renormalization. This changes the results substantially.

  14. From Protein Structure to Function via Single Crystal Optical Spectroscopy

    Directory of Open Access Journals (Sweden)

    Luca eRonda

    2015-04-01

    Full Text Available The more than 100.000 protein structures determined by X-ray crystallography provide a wealth of information for the characterization of biological processes at the molecular level. However, several crystallographic artifacts, including conformational selection, crystallization conditions and radiation damages, may affect the quality and the interpretation of the electron density map, thus limiting the relevance of structure determinations. Moreover, for most of these structures no functional data have been obtained in the crystalline state, thus posing serious questions on their validity in the inference for protein mechanisms. In order to solve these issues, spectroscopic methods have been applied for the determination of equilibrium and kinetic properties of proteins in the crystalline state. These methods are UV-vis spectrophotometry, spectrofluorimetry, IR, EPR, Raman and resonance Raman spectroscopy. Some of these approaches have been implemented with on-line instruments at X-ray synchrotron beamlines. Here, we provide an overview of investigations predominantly carried out in our laboratory by single crystal polarized absorption UV-vis microspectrophotometry, the most applied technique for the functional characterization of proteins in the crystalline state. Studies on hemoglobins, pyridoxal 5’-phosphate dependent enzymes and green fluorescent protein in the crystalline state have addressed key biological issues, leading to either straightforward structure-function correlations or limitations to structure-based mechanisms.

  15. Structure-Function Studies on the Prolactin Receptor

    DEFF Research Database (Denmark)

    Haxholm, Gitte Wolfsberg

    Class 1 Cytokine receptors are involved in important biological functions mediated through complex networks of intracellular signaling. However, the molecular details of how signaling is regulated are poorly understood. One of the primary reasons for this limited knowledge is the lack of structural...... information on the intracellular domains (ICDs) of these receptors. The overall aim of this study was to obtain an improved understanding of cytokine receptor signaling through structure-function studies on the prolactin receptor (PRLR). The primary focus of this thesis was to structurally characterize...... the PRLR-ICD and the ICD of the related growth hormone receptor (GHR). We showed that both ICDs were intrinsically disordered throughout their entire lengths and that they associated with lipids characteristic of the inner plasma membrane leaflet through conserved motifs, implicating the membrane...

  16. CNS structures presumably involved in vagal control of ovarian function.

    Science.gov (United States)

    Gerendai, I; Tóth, I E; Boldogköi, Z; Medveczky, I; Halász, B

    2000-04-12

    The contribution of the vagus nerve to viral transneuronal labeling of brain structures from the ovaries demonstrated recently by us was investigated. Unilateral vagotomy was performed prior to ipsilateral intraovarian virus injection. Virus-infected neurons were visualized by immunostaining. In vagotomized rats such neurons were detected only in certain cell groups of the brain (parapyramidal nucleus, A(1), A(5) cell group, caudal raphe nuclei, hypothalamic paraventricular nucleus, lateral hypothalamus). Vagotomy interfered with labeling of several structures that were labeled in controls, including area postrema, nucleus of the solitary tract, dorsal vagal complex, nucleus ambiguus, A(7) cell group, Barrington's nucleus, locus coeruleus, periaqueductal gray, dorsal hypothalamus. Findings provide a morphological basis to study the functional significance of brain structures presumably involved in the control of ovarian function and acting via the vagus or the sympathetic nerves.

  17. The Structure and Function of Non-Collagenous Bone Proteins

    Science.gov (United States)

    Hook, Magnus; McQuillan, David J.

    1997-01-01

    The research done under the cooperative research agreement for the project titled 'The structure and function of non-collagenous bone proteins' represented the first phase of an ongoing program to define the structural and functional relationships of the principal noncollagenous proteins in bone. An ultimate goal of this research is to enable design and execution of useful pharmacological compounds that will have a beneficial effect in treatment of osteoporosis, both land-based and induced by long-duration space travel. The goals of the now complete first phase were as follows: 1. Establish and/or develop powerful recombinant protein expression systems; 2. Develop and refine isolation and purification of recombinant proteins; 3. Express wild-type non-collagenous bone proteins; 4. Express site-specific mutant proteins and domains of wild-type proteins to enhance likelihood of crystal formation for subsequent solution of structure.

  18. DMPD: Structural and functional analyses of bacterial lipopolysaccharides. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 12106784 Structural and functional analyses of bacterial lipopolysaccharides. Carof...html) (.csml) Show Structural and functional analyses of bacterial lipopolysaccharides. PubmedID 12106784 Ti...tle Structural and functional analyses of bacterial lipopolysaccharides. Authors

  19. Correlation function as a measure of the structure

    CERN Document Server

    Buryak, O E

    1995-01-01

    Geometrical model of structure of the universe is examined to obtain analytical expression for the two points nonlinear correlation function. According to the model the objects (galaxies) are concentrated into two types of structure elements - filaments and sheets. We considered the filaments ( similar to galaxy filaments ) simply as straight lines and the sheets ( similar to superclusters of galaxies ) simply as planes. The homogeneously distributed objects are also taken into consideration. The spatial distribution of lines, planes and points is uncorrelated. The nonlinear correlation function depends on four parameters and is similar to the observed and simulated ones for different samples. It describes quite well the correlation of galaxies, clusters of galaxies and dark matter distribution. Possible interpretation of the parameters of nonlinear correlation function is discussed.

  20. 2011 Plant Lipids: Structure, Metabolism, & Function Gordon Research Conference

    Energy Technology Data Exchange (ETDEWEB)

    Christopher Benning

    2011-02-04

    This is the second Gordon Research Conference on 'Plant Lipids: Structure, Metabolism & Function'. It covers current topics in lipid structure, metabolism and function in eukaryotic photosynthetic organisms including seed plants, algae, mosses and ferns. Work in photosynthetic bacteria is considered as well as it serves the understanding of specific aspects of lipid metabolism in plants. Breakthroughs are discussed in research on plant lipids as diverse as glycerolipids, sphingolipids, lipids of the cell surface, isoprenoids, fatty acids and their derivatives. The program covers nine concepts at the forefront of research under which afore mentioned plant lipid classes are discussed. The goal is to integrate areas such as lipid signaling, basic lipid metabolism, membrane function, lipid analysis, and lipid engineering to achieve a high level of stimulating interaction among diverse researchers with interests in plant lipids. One Emphasis is on the dynamics and regulation of lipid metabolism during plant cell development and in response to environmental factors.

  1. A-dependence of weak nuclear structure functions

    Energy Technology Data Exchange (ETDEWEB)

    Haider, H.; Athar, M. Sajjad [Department of Physics, Aligarh Muslim University, Aligarh-202 002 (India); Simo, I. Ruiz [Dipartimento di Fisica, Universitá degli studi di Trento Via Sommarive 14, Povo (Trento) I-38123 (Italy)

    2015-05-15

    Effect of nuclear medium on the weak structure functions F{sub 2}{sup A}(x, Q{sup 2}) and F{sub 3}{sup A}(x, Q{sup 2}) have been studied using charged current (anti)neutrino deep inelastic scattering on various nuclear targets. Relativistic nuclear spectral function which incorporate Fermi motion, binding and nucleon correlations are used for the calculations. We also consider the pion and rho meson cloud contributions calculated from a microscopic model for meson-nucleus self-energies. Using these structure functions, F{sub i}{sup A}/F{sub i}{sup proton} and F{sub i}{sup A}/F{sub i}{sup deuteron}(i=2,3, A={sup 12}C, {sup 16}O, CH and H{sub 2}O) are obtained.

  2. R-ratios and moments of nuclear structure functions

    CERN Document Server

    Rinat, A S

    2000-01-01

    We study implications of a model, which links nuclear and nucleon structure functions. Computed Callen-Gross functions $\\kappa^A(x,Q^2)= 2xF_1^A(x,Q^2)/F_2^A(x,Q^2)$ appear for finite $Q^2$ to be close to their asymptotic value 1. Using those $\\kappa$, we compure $R$ ratios for $Q^2\\ge 5 GeV^2$. We review approximate methods in use for the extraction of $R$ from inclusive scattering and ENC data. Further we calcuate ratios of the moments of $F_k$ and find these to describe the data, in particular their $Q^2$ dependence. The above observables, as well as inclusive cross sections, are sensitive tests for the underlying relation between nucleonic and nuclear structure functions. In view of the overall agreement, we speculate that the above relation effectively circumvents a QCD calculation.

  3. Structure Function Sum rules for Systems with Large Scattering Lengths

    CERN Document Server

    Goldberger, Walter D

    2010-01-01

    We use a dispersion relation in conjunction with the operator product expansion (OPE) to derive model independent sum rules for the dynamic structure functions of systems with large scattering lengths. We present an explicit sum rule for the structure functions that control the density and spin response of the many-body ground state. Our methods are general, and apply to either fermions or bosons which interact through two-body contact interactions with large scattering lengths. By employing a Borel transform of the OPE, the relevant integrals are weighted towards infrared frequencies, thus allowing for greater overlap low energy data. Similar sum rules can be derived for other response functions. The sum rules can be used to extract the contact parameter introduced by Tan, including universality violating corrections at finite scattering lengths.

  4. Towards fully automated structure-based function prediction in structural genomics: a case study.

    Science.gov (United States)

    Watson, James D; Sanderson, Steve; Ezersky, Alexandra; Savchenko, Alexei; Edwards, Aled; Orengo, Christine; Joachimiak, Andrzej; Laskowski, Roman A; Thornton, Janet M

    2007-04-13

    As the global Structural Genomics projects have picked up pace, the number of structures annotated in the Protein Data Bank as hypothetical protein or unknown function has grown significantly. A major challenge now involves the development of computational methods to assign functions to these proteins accurately and automatically. As part of the Midwest Center for Structural Genomics (MCSG) we have developed a fully automated functional analysis server, ProFunc, which performs a battery of analyses on a submitted structure. The analyses combine a number of sequence-based and structure-based methods to identify functional clues. After the first stage of the Protein Structure Initiative (PSI), we review the success of the pipeline and the importance of structure-based function prediction. As a dataset, we have chosen all structures solved by the MCSG during the 5 years of the first PSI. Our analysis suggests that two of the structure-based methods are particularly successful and provide examples of local similarity that is difficult to identify using current sequence-based methods. No one method is successful in all cases, so, through the use of a number of complementary sequence and structural approaches, the ProFunc server increases the chances that at least one method will find a significant hit that can help elucidate function. Manual assessment of the results is a time-consuming process and subject to individual interpretation and human error. We present a method based on the Gene Ontology (GO) schema using GO-slims that can allow the automated assessment of hits with a success rate approaching that of expert manual assessment.

  5. Structural Bases of Stability-Function Tradeoffs in Enzymes

    Energy Technology Data Exchange (ETDEWEB)

    Beadle, Beth M; Shoichet, Brian K [NWU, MED

    2010-03-05

    The structures of enzymes reflect two tendencies that appear opposed. On one hand, they fold into compact, stable structures; on the other hand, they bind a ligand and catalyze a reaction. To be stable, enzymes fold to maximize favorable interactions, forming a tightly packed hydrophobic core, exposing hydrophilic groups, and optimizing intramolecular hydrogen-bonding. To be functional, enzymes carve out an active site for ligand binding, exposing hydrophobic surface area, clustering like charges, and providing unfulfilled hydrogen bond donors and acceptors. Using AmpC {beta}-lactamase, an enzyme that is well-characterized structurally and mechanistically, the relationship between enzyme stability and function was investigated by substituting key active-site residues and measuring the changes in stability and activity. Substitutions of catalytic residues Ser64, Lys67, Tyr150, Asn152, and Lys315 decrease the activity of the enzyme by 10{sup 3}-10{sup 5}-fold compared to wild-type. Concomitantly, many of these substitutions increase the stability of the enzyme significantly, by up to 4.7 kcal/mol. To determine the structural origins of stabilization, the crystal structures of four mutant enzymes were determined to between 1.90 {angstrom} and 1.50 {angstrom} resolution. These structures revealed several mechanisms by which stability was increased, including mimicry of the substrate by the substituted residue (S64D), relief of steric strain (S64G), relief of electrostatic strain (K67Q), and improved polar complementarity (N152H). These results suggest that the preorganization of functionality characteristic of active sites has come at a considerable cost to enzyme stability. In proteins of unknown function, the presence of such destabilized regions may indicate the presence of a binding site.

  6. Measurement of charm and beauty production in deep inelastic scattering at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Roloff, Philipp

    2011-12-15

    In this thesis two measurements of heavy quark production in deep inelastic scattering at HERA are presented. Cross sections for the production of heavy quarks can be calculated in quantum chromodynamics (QCD). The heavy quark masses represent hard scales, which allow to apply perturbative methods. Charm production has been measured with the ZEUS detector using an integrated luminosity of 120 pb{sup -1}. The hadronic decay channels D{sup +} {yields} K{sup 0}{sub S}{pi}{sup +}, {lambda}{sup +}{sub c} {yields} pK{sup 0}{sub S} and {lambda}{sup +}{sub c} {yields} {lambda}{pi}{sup +} were reconstructed. The presence of a neutral strange hadron in the final state reduces the combinatorial background and extends the measured sensitivity into the region p{sub T}(D{sup +}, {lambda}{sup +}{sub c}) < 1.5 GeV. The inclusive cross section and differential cross sections in p{sub T}{sup 2} (D{sup +}), {eta}(D{sup +}), Q{sup 2} and x for the production of D{sup +} mesons are in reasonable agreement with predictions from perturbative QCD. The fraction of c quarks hadronising into {lambda}{sup +}{sub c} baryons was extracted from a combination of both investigated {lambda}{sup +}{sub c} decay channels. The result is consistent with a previous measurement in the photoproduction regime and with the average e{sup +}e{sup -} value. The production of charm and beauty quarks has been measured with the ZEUS detector using the data collected between 2004 and 2007. This data sample corresponds to an integrated luminosity of 354 pb{sup -1}. The charm and beauty contents in events with a jet were determined using the decay-length significance and invariant mass of the reconstructed secondary decay vertices. Differential cross sections in E{sup jet}{sub T}, {eta}{sup jet}, Q{sup 2} and x are in reasonable agreement with predictions for perturbative QCD. The open charm and beauty contributions to the inclusive proton structure function F{sub 2} were extracted from double differential cross

  7. Can we measure beauty? Computational evaluation of coral reef aesthetics

    NARCIS (Netherlands)

    Haas, A.F.; Guibert, M.; Foerschner, A.; Co, T.; Calhoun, S.; George, E.; Hatay, M.; Dinsdale, E.; Sandin, S.A.; Smith, J.E.; Vermeij, M.J.A.; Felts, B.; Dustan, P.; Salamon, P.; Rohwer, F.

    2015-01-01

    The natural beauty of coral reefs attracts millions of tourists worldwide resulting in substantial revenues for the adjoining economies. Although their visual appearance is a pivotal factor attracting humans to coral reefs current monitoring protocols exclusively target biogeochemical parameters, ne

  8. Measurement of beauty production from dimuon events at HERA

    CERN Document Server

    Chekanov, S; Magill, S; Musgrave, B; Nicholass, D; Repond, J; Yoshida, R; Mattingly, M C K; Antonioli, P; Bari, G; Bellagamba, L; Boscherini, D; Bruni, A; Bruni, G; Cindolo, F; Corradi, M; Iacobucci, G; Margotti, A; Nania, R; Polini, A; Antonelli, S; Basile, M; Bindi, M; Cifarelli, L; Contin, A; DePasquale, S; Sartorelli, G; Zichichi, A; Bartsch, D; Brock, I; Hartmann, H; Hilger, E; Jakob, H P; Jüngst, M; Nuncio-Quiroz, A E; Paul, E; Samson, U; Schonberg, V; Shehzadi, R; Wlasenko, M; Brook, N H; Heath, G P; Morris, J D; Kaur, M; Kaur, P; Singh, I; Capua, M; Fazio, S; Mastroberardino, A; Schioppa, M; Susinno, G; Tassi, E; Kim, J Y; Ibrahim, Z A; Kamaluddin, B; WanAbdullah, W A T; Ning, Y; Ren, Z; Sciulli, F; Chwastowski, J; Eskreys, A; Figiel, J; Galas, A; Olkiewicz, K; Stopa, P; Zawiejski, L; Adamczyk, L; Bold, T; Grabowska-Bold, I; Kisielewska, D; Lukasik, J; Przybycien, M; Suszycki, L; Kotanski, A; Slominski, W; Behnke, O; Behrens, U; Bloch, I; Blohm, C; Bonato, A; Borras, K; Bot, D; Ciesielski, R; Coppola, N; Fang, S; Fourletova, J; Geiser, A; Göttlicher, P; Grebenyuk, J; Gregor, I; Gutsche, O; Haas, T; Hain, W; Huttmann, A; Januschek, F; Kahle, B; Katkov, I; Klein, U; Kötz, U; Kowalski, H; Lisovyi, M; Lobodzinska, E; Löhr, B; Mankel, R; Melzer-Pellmann, I A; Miglioranzi, S; Montanari, A; Namsoo, T; Notz, D; Parenti, A; Rinaldi, L; Roloff, P; Rubinsky, I; Schneekloth, U; Spiridonov, A; Szuba, D; Szuba, J; Theedt, T; Ukleja, J; Wolf, G; Wrona, K; YaguesMolina, A G; Youngman, C; Zeuner, W; Drugakov, V; Lohmann, W; Schlenstedt, S; Barbagli, G; Gallo, E; Pelfer, P G; Bamberger, A; Dobur, D; Karstens, F; Vlasov, N N; Bussey, P J; Doyle, A T; Dunne, W; Forrest, M; Rosin, M; Saxon, D H; Skillicorn, I O; Gialas, I; Papageorgiu, K; Holm, U; Klanner, R; Lohrmann, E; Perrey, H; Schleper, P; Schörner-Sadenius, T; Sztuk, J; Stadie, H; Turcato, M; Foudas, C; Fry, C; Long, K R; Tapper, A D; Matsumoto, T; Nagano, K; Tokushuku, K; Yamada, S; Yamazaki, Y; Barakbaev, A N; Boos, E G; Pokrovskiy, N S; Zhautykov, B O; Aushev, V; Bachynska, O; Borodin, M; Kadenko, I; Kozulia, A; Libov, V; Lontkovskyi, D; Makarenko, I; Sorokin, Iu; Verbytskyi, A; Volynets, O; Son, D; deFavereau, J; Piotrzkowski, K; Barreiro, F; Glasman, C; Jiménez, M; Labarga, L; delPeso, J; Ron, E; Soares, M; Terron, J; Zambrana, M; Corriveau, F; Liu, C; Schwartz, J; Walsh, R; Zhou, C; Tsurugai, T; Antonov, A; Dolgoshein, B A; Gladkov, D; Sosnovtsev, V; Stifutkin, A; Suchkov, S; Dementiev, R K; Ermolov, P F; Gladilin, L K; Golubkov, Yu A; Khein, L A; Korzhavina, I A; Kuzmin, V A; Levchenko, B B; Lukina, O Yu; Proskuryakov, A S; Shcheglova, L M; Zotkin, D S; Abt, I; Caldwell, A; Kollar, D; Reisert, B; Schmidke, W B; Grigorescu, G; Keramidas, A; Koffeman, E; Kooijman, P; Pellegrino, A; Tiecke, H; Vázquez, M; Wiggers, L; Brümmer, N; Bylsma, B; Durkin, L S; Lee, A; Ling, T Y; Allfrey, P D; Bell, M A; Cooper-Sarkar, A M; Devenish, R C E; Ferrando, J; Foster, B; Gwenlan, C; Korcsak-Gorzo, K; Oliver, K; Robertson, A; Uribe-Estrada, C; Walczak, R; Bertolin, A; Dal Corso, F; Dusini, S; Longhin, A; Stanco, L; Bellan, P; Brugnera, R; Carlin, R; Garfagnini, A; Limentani, S; Oh, B Y; Raval, A; Whitmore, J J; Iga, Y; D'Agostini, G; Marini, G; Nigro, A; Cole, J E; Hart, J C; Abramowicz, H; Ingbir, R; Kananov, S; Levy, A; Stern, A; Kuze, M; Maeda, J; Hori, R; Kagawa, S; Okazaki, N; Shimizu, S; Tawara, T; Hamatsu, R; Kaji, H; Kitamura, S; Ota, O; Ri, Y D; Costa, M; Ferrero, M I; Monaco, V; Sacchi, R; Solano, A; Arneodo, M; Ruspa, M; Fourletov, S; Martin, J F; Stewart, T P; Boutle, S K; Butterworth, J M; Jones, T W; Loizides, J H; Wing, M; Brzozowska, B; Ciborowski, J; Grzelak, G; Kulinski, P; Luzniak, P; Malka, J; Nowak, R J; Pawlak, J M; Perlanski, W; Tymieniecka, T; Zarnecki, A F; Adamus, M; Plucinsky, P P; Ukleja, A; Eisenberg, Y; Hochman, D; Karshon, U; Brownson, E; Reeder, D D; Savin, A A; Smith, W H; Wolfe, H; Bhadra, S; Catterall, C D; Cui, Y; Hartner, G; Menary, S; Noor, U; Standage, J; Whyte, J

    2009-01-01

    Beauty production in events containing two muons in the final state has been measured with the ZEUS detector at HERA using an integrated luminosity of 114 pb-1. A low transverse-momentum threshold for muon identification, in combination with the large rapidity coverage of the ZEUS muon system, gives access to almost the full phase space for beauty production. The total cross section for beauty production in ep collisions at sqrt(s)= 318 GeV has been measured to be sigma_tot(ep -> bbbar X) = 13.9 +- 1.5(stat.) +4.0 -4.3(syst.) nb. Differential cross sections and a measurement of bbbar correlations are also obtained, and compared to other beauty cross-section measurements, Monte Carlo models and next-to-leading-order QCD predictions.

  9. Isovector and hidden-beauty partners of the X(3872)

    Energy Technology Data Exchange (ETDEWEB)

    Høgaasen, Hallstein, E-mail: hallstein.hogasen@fys.uio.no [Department of Physics, University of Oslo, Box 1048, NO-0316 Oslo (Norway); Kou, Emi, E-mail: kou@lal.in2p3.fr [Laboratoire de l' Accélérateur Linéaire, Université Paris-Sud, IN2P3-CNRS, Centre Scientifique d' Orsay, 91898 Orsay Cedex (France); Richard, Jean-Marc, E-mail: j-m.richard@ipnl.in2p3.fr [Université de Lyon, Institut de Physique Nucléaire de Lyon, UCBL–IN2P3-CNRS, 4, rue Enrico Fermi, 69622 Villeurbanne Cedex (France); Sorba, Paul, E-mail: paul.sorba@lapth.cnrs.fr [LAPTh, Laboratoire d' Annecy-le-Vieux de Physique Théorique, CNRS, Université de Savoie, BP 110, 74941 Annecy-le-Vieux Cedex (France)

    2014-05-01

    The isovector partners of the X(3872), recently found at BES III, Belle and CLEO-c were predicted in a simple model based on the chromomagnetic interaction among quarks. The extension to the hidden-beauty sector is discussed.

  10. Sunflower Beauty Contest : tsvetõ zimoi / Marina Poltavtseva

    Index Scriptorium Estoniae

    Poltavtseva, Marina

    2001-01-01

    Lillekleitide võistlusest Sunflower Beauty Contest Tallinna klubis Decolte. Konkursi idee on florist Tatjana Tridvornovalt. Esimese koha sai Viimsi lilleäri lilleseadjate Meri-Liis Kõivu ja Triinu Põlderi lillekleit "Talvepruut"

  11. Trinity and beauty: The theological contribution of Jonathan Edwards

    Directory of Open Access Journals (Sweden)

    R. Venter

    2012-02-01

    Full Text Available The article explores the relationship between the trinitarian confession of God and beauty. Special attention is paid to Jonathan Edwards, the eighteenth-centur ypreacher and thinker, who in an exceptional manner viewed God in terms of beauty. The discussion is located in the context of a vigorous international Edwardsian scholarship on metaphysics, the nature of God and aesthetics. The article points out that beauty, according to Edwards, is primarily relational. The article aims at contributing to two neglected scholarly areas – the treatment of the doctrine of God in aesthetic terms, and the study of Jonathan Edwards in a South African context. Areas for further reflection are also identified. The article intimates that a discussion about trinity and beauty may have social ramifications.

  12. Measurement of beauty production from dimuon events at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Chekanov, S.; Derrick, M.; Magill, S. [Argonne National Laboratory, Argonne, IL (United States)] (and others)

    2008-09-15

    Beauty production in events containing two muons in the final state has been measured with the ZEUS detector at HERA using an integrated luminosity of 114 pb{sup -1}. A low transverse-momentum threshold for muon identification, in combination with the large rapidity coverage of the ZEUS muon system, gives access to almost the full phase space for beauty production. The total cross section for beauty production in ep collisions at {radical}(s) = 318 GeV has been measured to be {sigma}{sub tot}(ep {yields} b anti bX) = 13.9 {+-} 1.5(stat.){sub -4.3}{sup +4.0}(syst.) nb. Differential cross sections and a measurement of b anti b correlations are also obtained, and compared to other beauty cross-section measurements, Monte Carlo models and next-to-leading-order QCD predictions. (orig.)

  13. Origins, structures, and functions of circulating DNA in oncology.

    Science.gov (United States)

    Thierry, A R; El Messaoudi, S; Gahan, P B; Anker, P; Stroun, M

    2016-09-01

    While various clinical applications especially in oncology are now in progress such as diagnosis, prognosis, therapy monitoring, or patient follow-up, the determination of structural characteristics of cell-free circulating DNA (cirDNA) are still being researched. Nevertheless, some specific structures have been identified and cirDNA has been shown to be composed of many "kinds." This structural description goes hand-in-hand with the mechanisms of its origins such as apoptosis, necrosis, active release, phagocytosis, and exocytose. There are multiple structural forms of cirDNA depending upon the mechanism of release: particulate structures (exosomes, microparticles, apoptotic bodies) or macromolecular structures (nucleosomes, virtosomes/proteolipidonucleic acid complexes, DNA traps, links with serum proteins or to the cell-free membrane parts). In addition, cirDNA concerns both nuclear and/or mitochondrial DNA with both species exhibiting different structural characteristics that potentially reveal different forms of biological stability or diagnostic significance. This review focuses on the origins, structures and functional aspects that are paradoxically less well described in the literature while numerous reviews are directed to the clinical application of cirDNA. Differentiation of the various structures and better knowledge of the fate of cirDNA would considerably expand the diagnostic power of cirDNA analysis especially with regard to the patient follow-up enlarging the scope of personalized medicine. A better understanding of the subsequent fate of cirDNA would also help in deciphering its functional aspects such as their capacity for either genometastasis or their pro-inflammatory and immunological effects.

  14. Surface Appendages of Archaea: Structure, Function, Genetics and Assembly

    Directory of Open Access Journals (Sweden)

    Sarah Siu

    2013-01-01

    Full Text Available Organisms representing diverse subgroupings of the Domain Archaea are known to possess unusual surface structures. These can include ones unique to Archaea such as cannulae and hami as well as archaella (archaeal flagella and various types of pili that superficially resemble their namesakes in Bacteria, although with significant differences. Major advances have occurred particularly in the study of archaella and pili using model organisms with recently developed advanced genetic tools. There is common use of a type IV pili-model of assembly for several archaeal surface structures including archaella, certain pili and sugar binding structures termed bindosomes. In addition, there are widespread posttranslational modifications of archaellins and pilins with N-linked glycans, with some containing novel sugars. Archaeal surface structures are involved in such diverse functions as swimming, attachment to surfaces, cell to cell contact resulting in genetic transfer, biofilm formation, and possible intercellular communication. Sometimes functions are co-dependent on other surface structures. These structures and the regulation of their assembly are important features that allow various Archaea, including thermoacidophilic, hyperthermophilic, halophilic, and anaerobic ones, to survive and thrive in the extreme environments that are commonly inhabited by members of this domain.

  15. Protein Function Prediction Based on Sequence and Structure Information

    KAUST Repository

    Smaili, Fatima Z.

    2016-05-25

    The number of available protein sequences in public databases is increasing exponentially. However, a significant fraction of these sequences lack functional annotation which is essential to our understanding of how biological systems and processes operate. In this master thesis project, we worked on inferring protein functions based on the primary protein sequence. In the approach we follow, 3D models are first constructed using I-TASSER. Functions are then deduced by structurally matching these predicted models, using global and local similarities, through three independent enzyme commission (EC) and gene ontology (GO) function libraries. The method was tested on 250 “hard” proteins, which lack homologous templates in both structure and function libraries. The results show that this method outperforms the conventional prediction methods based on sequence similarity or threading. Additionally, our method could be improved even further by incorporating protein-protein interaction information. Overall, the method we use provides an efficient approach for automated functional annotation of non-homologous proteins, starting from their sequence.

  16. Improved Left Ventricular Structure and Function After Successful Kidney Transplantation

    Directory of Open Access Journals (Sweden)

    Bernd Hewing

    2016-10-01

    Full Text Available Background/Aims: Cardiac changes observed in chronic kidney disease patients are of multifactorial origin including chronic uremia, hemodynamics or inflammation. Restoration of renal function by kidney transplantation (KTX may reverse cardiac changes. Novel echocardiographic methods such as speckle tracking echocardiography (STE allow early and sensitive detection of subtle changes of cardiac parameters. We evaluated changes of cardiac structure and function after KTX by advanced echocardiographic modalities. Methods: Thirty-one KTX recipients (female n=11 were evaluated by medical examination, laboratory testing and echocardiography before and after KTX (median follow-up 19 months. Left ventricular (LV and right ventricular (RV diameters and function were assessed by echocardiographic standard parameters. Longitudinal 2D strain of the LV (GLPS and left atrium (LA was determined by 2D STE. Results: After KTX, median serum creatinine level was 1.3 mg/dl (IQR, 1.2-1.5. Systolic blood pressure decreased significantly after KTX. Echocardiography showed a significant reduction in LV end-diastolic septal and posterior wall thickness and LV mass index after KTX, which was accompanied by an improvement of GLPS. There were no relevant changes in parameters of LA (reservoir, conduit or contractile function, LV diastolic or RV function after KTX. Conclusion: LV hypertrophy reversed after successful KTX and was accompanied by an improvement in longitudinal LV function as assessed by STE. Diastolic function and STE-derived LA function parameters did not change significantly after KTX.

  17. The Effects of Novelty and Familiarity on Beauty Perception

    OpenAIRE

    Hyejeong Jang; Han Nim Cha; Woo Hyun Jung

    2011-01-01

    In order to investigate how novelty and familiarity affect beauty perception, fractal images were presented five times over 14 weeks. Fractal images are unfamiliar to people, hence used in this study to control their previous experience. a total of 800 fractal images were divided into five groups (160 images X 5 group), and three groups of images were presented to participants each time for five times. The results showed that while beauty perception is decreased until the third exposure, it i...

  18. Class I Cytokine Receptors: Structure and function in the Membrane

    DEFF Research Database (Denmark)

    Bugge, Katrine Østergaard

    Class I cytokine receptors are involved in important biological functions of both physiological and pathological nature in mammals. However, the molecular details of the cross-membrane signal transduction through these receptors remain obscure. One of the major reasons for this is the lack...... of structural knowledge on their membrane-embedded transmembrane domains (TMDs), which connect the extracellular ligand binding domains to the intracellular signaling platforms. The overall aim of this thesis work was to improve our understanding of the class I cytokine receptor signaling across the membrane...... ample material of high quality for structural studies with NMR spectroscopy of several class I cytokine receptor TMDs. Furthermore, the structure of a class I cytokine receptor TMD in DHPC micelles was solved with solution-state NMR spectroscopy. Additionally, since structural studies of intact proteins...

  19. Structural and functional significance of water permeation through cotransporters

    DEFF Research Database (Denmark)

    Zeuthen, Thomas; Gorraitz, Edurne; Her, Ka;

    2016-01-01

    to be due to alterations in steric hindrance to water and urea, and/or changes in protein folding caused by mismatching of side chains in the water pathway. Water permeation through SGLT1 and other transporters bears directly on the structural mechanism for the transport of polar solutes through......Membrane transporters, in addition to their major role as specific carriers for ions and small molecules, can also behave as water channels. However, neither the location of the water pathway in the protein nor their functional importance is known. Here, we map the pathway for water and urea...... through the intestinal sodium/glucose cotransporter SGLT1. Molecular dynamics simulations using the atomic structure of the bacterial transporter vSGLT suggest that water permeates the same path as Na+ and sugar. On a structural model of SGLT1, based on the homology structure of vSGLT, we identified...

  20. Surface structure of polymer Gels and emerging functions

    CERN Document Server

    Kobiki, Y

    1999-01-01

    We report the surface structure of polymer gels on a submicrometer scale during the volume phase transition. Sponge-like domains with a mesoscopic scale were directly observed in water by using at atomic force microscope (AFM). The surface structure characterized by the domains is discussed in terms of the root-mean-square roughness and the auto-correlation function, which were calculated from the AFM images. In order to demonstrate the role of surface structure in determining the macroscopic properties of film-like poly (N-isopropylacrylamide: NIPA) gels. It was found that the temperature dependence, as well as the absolute values of the static contact angle, were strongly dependent on the bulk network inhomogeneities. The relation between the mesoscopic structure and the macroscopic properties is qualitatively discussed in terms of not only the changes in the chemical, but also in the physical, surface properties of the NIPA gels in response to a temperature change.