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Sample records for beauty mediates therapeutic

  1. Sleeping Beauty-Mediated Drug Resistance Gene Transfer in Human Hematopoietic Progenitor Cells.

    Science.gov (United States)

    Hyland, Kendra A; Olson, Erik R; McIvor, R Scott

    2015-10-01

    The Sleeping Beauty (SB) transposon system can insert sequences into mammalian chromosomes, supporting long-term expression of both reporter and therapeutic genes. Hematopoietic progenitor cells (HPCs) are an ideal therapeutic gene transfer target as they are used in therapy for a variety of hematologic and metabolic conditions. As successful SB-mediated gene transfer into human CD34(+) HPCs has been reported by several laboratories, we sought to extend these studies to the introduction of a therapeutic gene conferring resistance to methotrexate (MTX), potentially providing a chemoprotective effect after engraftment. SB-mediated transposition of hematopoietic progenitors, using a transposon encoding an L22Y variant dihydrofolate reductase fused to green fluorescent protein, conferred resistance to methotrexate and dipyridamole, a nucleoside transport inhibitor that tightens MTX selection conditions, as assessed by in vitro hematopoietic colony formation. Transposition of individual transgenes was confirmed by sequence analysis of transposon-chromosome junctions recovered by linear amplification-mediated PCR. These studies demonstrate the potential of SB-mediated transposition of HPCs for expression of drug resistance genes for selective and chemoprotective applications. PMID:26176276

  2. Beauty..

    International Nuclear Information System (INIS)

    B-physics - the study of particles containing the fifth (beauty, or 'b') quark - is at a turning point. After the discovery of this quark at a proton machine - Fermilab - in 1977, most of our knowledge of its physics subsequently has come from experiments at electron-positron colliding beam machines. Although this tradition is continuing with the latest results emerging from the upgraded CLEO detector at Cornell (June 1993, page 1) and from the major B contributions of the LEP experiments at CERN, experiments at hadron colliders have begun to produce complementary results. First, the UA1 experiment at CERN's proton-antiproton collider saw the oscillation between different neutral B-mesons. Subsequently UA1 saw evidence for B-baryons (December 1991, page 29). Now, the CDF experiment at Fermilab's Tevatron collider has demonstrated that very clean samples of exclusive B-meson final states can routinely be obtained at hadron colliders and, using a silicon microvertex detector, has shown that B-meson lifetimes can be well measured. An ever increasing flow of new B-physics is expected from CDF in the near future. The First International Workshop on B-Physics at Hadron Machines, Beauty '93, held earlier this year at Liblice Castle, near Prague, in the new Czech Republic, reflected this trend. Representatives from most existing and proposed B-physics enterprises attended, providing a forum for detailed comparisons of all proposed methods of B experimentation

  3. Comparison of lentiviral and sleeping beauty mediated αβ T cell receptor gene transfer.

    Directory of Open Access Journals (Sweden)

    Anne-Christine Field

    Full Text Available Transfer of tumour antigen-specific receptors to T cells requires efficient delivery and integration of transgenes, and currently most clinical studies are using gamma retroviral or lentiviral systems. Whilst important proof-of-principle data has been generated for both chimeric antigen receptors and αβ T cell receptors, the current platforms are costly, time-consuming and relatively inflexible. Alternative, more cost-effective, Sleeping Beauty transposon-based plasmid systems could offer a pathway to accelerated clinical testing of a more diverse repertoire of recombinant high affinity T cell receptors. Nucleofection of hyperactive SB100X transposase-mediated stable transposition of an optimised murine-human chimeric T cell receptor specific for Wilm's tumour antigen from a Sleeping Beauty transposon plasmid. Whilst transfer efficiency was lower than that mediated by lentiviral transduction, cells could be readily enriched and expanded, and mediated effective target cells lysis in vitro and in vivo. Integration sites of transposed TCR genes in primary T cells were almost randomly distributed, contrasting the predilection of lentiviral vectors for transcriptionally active sites. The results support exploitation of the Sleeping Beauty plasmid based system as a flexible and adaptable platform for accelerated, early-phase assessment of T cell receptor gene therapies.

  4. RNA interference is responsible for reduction of transgene expression after Sleeping Beauty transposase mediated somatic integration.

    Directory of Open Access Journals (Sweden)

    Christina Rauschhuber

    Full Text Available BACKGROUND: Integrating non-viral vectors based on transposable elements are widely used for genetically engineering mammalian cells in functional genomics and therapeutic gene transfer. For the Sleeping Beauty (SB transposase system it was demonstrated that convergent transcription driven by the SB transposase inverted repeats (IRs in eukaryotic cells occurs after somatic integration. This could lead to formation of double-stranded RNAs potentially presenting targets for the RNA interference (RNAi machinery and subsequently resulting into silencing of the transgene. Therefore, we aimed at investigating transgene expression upon transposition under RNA interference knockdown conditions. PRINCIPAL FINDINGS: To establish RNAi knockdown cell lines we took advantage of the P19 protein, which is derived from the tomato bushy stunt virus. P19 binds and inhibits 21 nucleotides long, small-interfering RNAs and was shown to sufficiently suppress RNAi. We found that transgene expression upon SB mediated transposition was enhanced, resulting into a 3.2-fold increased amount of colony forming units (CFU after transposition. In contrast, if the transgene cassette is insulated from the influence of chromosomal position effects by the chicken-derived cHS4 insulating sequences or when applying the Forg Prince transposon system, that displays only negligible transcriptional activity, similar numbers of CFUs were obtained. CONCLUSION: In summary, we provide evidence for the first time that after somatic integration transposon derived transgene expression is regulated by the endogenous RNAi machinery. In the future this finding will help to further improve the molecular design of the SB transposase vector system.

  5. [Video games, a therapeutic mediator for teens].

    Science.gov (United States)

    Nickler, Christophe

    2015-10-01

    Teenagers love video games and other multimedia tools. Sometimes they love them too much, leading to addictive use. A child psychiatry team in Nancy has developed a therapeutic multimedia workshop to contribute to treating teens. PMID:26455625

  6. [The drawing as a therapeutic mediation tool for gifted children].

    Science.gov (United States)

    Leverrier, Jenny; Titia Rizzi, Alice; Mouchenik, Yoram

    2016-01-01

    Intellectual precocity arouses a number of preconceived ideas. While it labels the children concerned as gifted and destined to become exceptional adults, it confines and prescribes and does not guarantee academic success. Based on the hypothesis of the suffering of these children, mediation through drawing is a valuable therapeutic tool. PMID:27015700

  7. Human neutrophil elastase: mediator and therapeutic target in atherosclerosis.

    Science.gov (United States)

    Henriksen, Peter A; Sallenave, Jean-Michel

    2008-01-01

    Human neutrophil elastase (HNE) is present within atherosclerotic plaques where it contributes to matrix degradation and weakening of the vessel wall associated with the complications of aneurysm formation and plaque rupture. It is joined by other extracellular proteases in these actions but the broad range of substrates and potency of HNE coupled with the potential for rapid increases in HNE activity associated with neutrophil degranulation in acute coronary syndromes single this disruptive protease out as therapeutic target in atherosclerotic disease. This review summarises the role of HNE in neutrophil-mediated endothelial injury and the evidence for HNE as a mediator of atherosclerotic plaque development. The therapeutic potential of HNE neutralising antiproteases, alpha-1-antitrypsin and elafin, in atherosclerosis, is discussed. PMID:18289916

  8. Derivation and characterization of sleeping beauty transposon-mediated porcine induced pluripotent stem cells

    DEFF Research Database (Denmark)

    Kues, Wilfried A.; Herrmann, Doris; Barg-Kues, Brigitte;

    2013-01-01

    the nonviral Sleeping Beauty transposon system to deliver the reprogramming factors Oct4, Sox2, Klf4, and cMyc. Successful reprogramming to a pluripotent state was indicated by changes in cell morphology and reactivation of the Oct4-EGFP reporter. The transposon-reprogrammed induced pluripotent stem...... (iPS) cells showed long-term proliferation in vitro over >40 passages, expressed transcription factors typical of embryonic stem cells, including OCT4, NANOG, SOX2, REX1, ESRRB, DPPA5, and UTF1 and surface markers of pluripotency, including SSEA-1 and TRA-1-60. In vitro differentiation resulted in...

  9. AAV-mediated miRNA Delivery and Therapeutics

    OpenAIRE

    Xie, Jun; Burt, Daniel Robert; Gao, Guangping

    2015-01-01

    MicroRNAs are 20-24 nt long, single-stranded RNAs that repress gene expression. Dysregulation of miRNA expression is associated with many human diseases. Modulating the level of endogenous miRNA alters gene profiling and can achieve therapeutic benefits. Here, we reviewed currently used methods of altering miRNA activity in vivo. We focus on the delivery of miRNAs and miRNA inhibitors using recombinant adeno-associated virus (rAAV). In general, rAAV-mediated miRNA inhibition or overexpression...

  10. Effective Expression-Independent Gene Trapping and Mutagenesis Mediated by Sleeping Beauty Transposon

    Institute of Scientific and Technical Information of China (English)

    Guili Song; Qing Li; Yong Long; Perry B. Hackett; Zongbin Cui

    2012-01-01

    Expression-independent gene or polyadenylation [poly(A)] trapping is a powerful tool for genome-wide mutagenesis regardless of whether a targeted gene is expressed.Although a number of poly(A)-trap vectors have been developed for the capture and mutation of genes across a vertebrate genome,further efforts are needed to avoid the 3′-terminal insertion bias and the splice donor (SD)read-through,and to improve the mutagenicity.Here,we present a Sleeping Beauty (SB) transposon-based vector that can overcome these limitations through the inclusion of three functional cassettes required for gene-finding,gene-breaking and large-scale mutagenesis,respectively.The functional cassette contained a reporter/selective marker gene driven by a constitutive promoter in front of a strong SD signal and an AU-rich RNA-destabilizing element (ARE),which greatly reduced the SD read-through events,except that the internal ribosomal entry site (IRES) element was introduced in front of the SD signal to overcome the phenomenon of 3′-bias gene trapping.The breaking cassette consisting of an enhanced splicing acceptor (SA),a poly(A) signal coupled with a transcriptional terminator (TT) effectively disrupted the transcription of trapped genes.Moreover,the Hsp70 promoter from tilapia genome was employed to drive the inducible expression of SB11,which allows the conditional remobilization of a trap insert from a non-coding region.The combination of three cassettes led to effective capture and disruption of endogenous genes in HeLa cells.In addition,the Cre/LoxP system was introduced to delete the Hsp70-SB11 cassette for stabilization of trapped gene interruption and biosafety.Thus,this poly(A)-trap vector is an alternative and effective tool for identification and mutation of endogenous genes in cells and animals.

  11. Lung Regeneration: Endogenous and Exogenous Stem Cell Mediated Therapeutic Approaches

    Directory of Open Access Journals (Sweden)

    Khondoker M. Akram

    2016-01-01

    Full Text Available The tissue turnover of unperturbed adult lung is remarkably slow. However, after injury or insult, a specialised group of facultative lung progenitors become activated to replenish damaged tissue through a reparative process called regeneration. Disruption in this process results in healing by fibrosis causing aberrant lung remodelling and organ dysfunction. Post-insult failure of regeneration leads to various incurable lung diseases including chronic obstructive pulmonary disease (COPD and idiopathic pulmonary fibrosis. Therefore, identification of true endogenous lung progenitors/stem cells, and their regenerative pathway are crucial for next-generation therapeutic development. Recent studies provide exciting and novel insights into postnatal lung development and post-injury lung regeneration by native lung progenitors. Furthermore, exogenous application of bone marrow stem cells, embryonic stem cells and inducible pluripotent stem cells (iPSC show evidences of their regenerative capacity in the repair of injured and diseased lungs. With the advent of modern tissue engineering techniques, whole lung regeneration in the lab using de-cellularised tissue scaffold and stem cells is now becoming reality. In this review, we will highlight the advancement of our understanding in lung regeneration and development of stem cell mediated therapeutic strategies in combating incurable lung diseases.

  12. The medicalization of beauty

    Directory of Open Access Journals (Sweden)

    Paulo Poli Neto

    2007-01-01

    Full Text Available Concern with body image and medical interventions related to physical beauty has greatly increased in the past few years. The purpose of this study is to investigate how medicine is dealing with the theme of beauty. The 2003/2004 editions of the periodicals Aesthetic Surgery Journal and Aesthetic Plastic Surgery were analyzed, in order to investigate the rationality buttressing their discourse. Three categories were prioritized for this study: definition of aesthetic plastic surgery's study object; beauty patterns guiding interventions; and understanding popular demand for aesthetic corrections. Discourse is sustained by biomedical rationality, structured around a disease theory and a dual construction between normal and pathological, with emphasis on biology. In the articles, the beauty patterns guiding therapeutic practices are anchored in biological norms defined through several anthropometric measures, which refer to abstract concepts of beauty, harmony, proportionality and symmetry. In this discourse, there are no references to patterns or to social norms of beauty; motivation for aesthetic intervention appears to be rooted in low self-esteem related to the aging process or to some bodily nonconformity. As per the meaning of 'medicalization' adopted herein, biomedical rationality appropriates variations or anomalies of physical appearance, thus allowing the theme to be dealt with in terms of health and disease, normal and pathological.

  13. Cell mediated therapeutics for cancer treatment: Tumor homing cells as therapeutic delivery vehicles

    Science.gov (United States)

    Balivada, Sivasai

    Many cell types were known to have migratory properties towards tumors and different research groups have shown reliable results regarding cells as delivery vehicles of therapeutics for targeted cancer treatment. Present report discusses proof of concept for 1. Cell mediated delivery of Magnetic nanoparticles (MNPs) and targeted Magnetic hyperthermia (MHT) as a cancer treatment by using in vivo mouse cancer models, 2. Cells surface engineering with chimeric proteins for targeted cancer treatment by using in vitro models. 1. Tumor homing cells can carry MNPs specifically to the tumor site and tumor burden will decrease after alternating magnetic field (AMF) exposure. To test this hypothesis, first we loaded Fe/Fe3O4 bi-magnetic NPs into neural progenitor cells (NPCs), which were previously shown to migrate towards melanoma tumors. We observed that NPCs loaded with MNPs travel to subcutaneous melanoma tumors. After alternating magnetic field (AMF) exposure, the targeted delivery of MNPs by the NPCs resulted in a mild decrease in tumor size (Chapter-2). Monocytes/macrophages (Mo/Ma) are known to infiltrate tumor sites, and also have phagocytic activity which can increase their uptake of MNPs. To test Mo/Ma-mediated MHT we transplanted Mo/Ma loaded with MNPs into a mouse model of pancreatic peritoneal carcinomatosis. We observed that MNP-loaded Mo/Ma infiltrated pancreatic tumors and, after AMF treatment, significantly prolonged the lives of mice bearing disseminated intraperitoneal pancreatic tumors (Chapter-3). 2. Targeted cancer treatment could be achieved by engineering tumor homing cell surfaces with tumor proteases cleavable, cancer cell specific recombinant therapeutic proteins. To test this, Urokinase and Calpain (tumor specific proteases) cleavable; prostate cancer cell (CaP) specific (CaP1 targeting peptide); apoptosis inducible (Caspase3 V266ED3)- rCasp3V266ED3 chimeric protein was designed in silico. Hypothesized membrane anchored chimeric protein (rCasp3V

  14. Beautiful Politicians

    OpenAIRE

    Amy King; Andrew Leigh

    2009-01-01

    Are beautiful politicians more likely to be elected? To test this, we use evidence from Australia, a country in which voting is compulsory, and in which voters are given ‘How to Vote’ cards depicting photos of the major party candidates as they arrive to vote. Using raters chosen to be representative of the electorate, we assess the beauty of political candidates from major political parties, and then estimate the effect of beauty on voteshare for candidates in the 2004 federal election. Beau...

  15. Beauty Redeemed

    DEFF Research Database (Denmark)

    Braae, Ellen Marie

    /PROAP’s Parque do Tejo e Trancão in Lisbon and Michel Desvigne’s Parc aux Angéliques in Bordeaux. Beauty Redeemed offers a systematic framework for the consideration and use of post-industrial sites. The author, Professor of Landscape Design at Copenhagen University, places these ‘leftovers’ in their broad......; it explores design work informed by a sensibility for redeemed beauty and various concepts of relating past, present and future...

  16. Targeting CD47-SIRPα interactions for potentiating therapeutic antibody-mediated tumor cell destruction by phagocytes

    OpenAIRE

    Zhao, X.W.

    2014-01-01

    The primary aim of the studies described in this thesis was to investigate the role of CD47-SIRPα interactions in therapeutic antibody-dependent tumor cell destruction by human phagocytes and also explore the killing mechanism(s) by which human phagocytes, and in particular human neutrophils, mediate therapeutic antibody-dependent cytotoxicity towards cancer cells.

  17. Beautiful equations

    Science.gov (United States)

    Viljamaa, Panu; Jacobs, J. Richard; Chris; JamesHyman; Halma, Matthew; EricNolan; Coxon, Paul

    2014-07-01

    In reply to a Physics World infographic (part of which is given above) about a study showing that Euler's equation was deemed most beautiful by a group of mathematicians who had been hooked up to a functional magnetic-resonance image (fMRI) machine while viewing mathematical expressions (14 May, http://ow.ly/xHUFi).

  18. Beautiful Flowers

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    春天到了,百花盛开,我们常说“美丽的鲜花”,就是:beautiful flowers。是不是觉得这两个单词有点儿难记呢?没关系,来玩玩我们的进宫吧,它能帮助你牢牢记住这两个单词的拼法。

  19. Beautiful city

    OpenAIRE

    Gerald A. Carlino

    2009-01-01

    Proponents of the City Beautiful movement advocated for sizable public investments in monumental spaces, street beautification, and classical architecture. Today, economists and policymakers see the provision of consumer leisure amenities as a way to attract people and jobs to cities. But past studies have provided only indirect evidence of the importance of leisure amenities for urban growth and development. In this article, Jerry Carlino uses a new data set on the number of leisure tourist ...

  20. Beautiful Serbia

    OpenAIRE

    Bonin, Holger; Rinne, Ulf

    2006-01-01

    The paper studies the causal impact of participation in an active labor market program - the 'Beautiful Serbia' program providing training and temporary work in the construction sector in Serbia and Montenegro - on measures of subjective well-being approximating individual welfare. According to our estimates, the positive impact of this particular program appears much stronger judged by subjective well-being than judged by the immediate labor market effect.

  1. City Beautiful

    OpenAIRE

    Gerald A. Carlino; Saiz, Albert

    2008-01-01

    The City Beautiful movement, which in the early 20th century advocated city beautification as a way to improve the living conditions and civic virtues of the urban dweller, had languished by the Great Depression. Today, new urban economic theorists and policymakers are coming to see the provision of consumer leisure amenities as a way to attract population, especially the highly skilled and their employers. However, past studies have provided only indirect evidence of the importance of leisur...

  2. Beautiful kit

    OpenAIRE

    Mark Miodownik

    2004-01-01

    Mark Miodownik reports on laboratory machines such as scanning electron microscopes with energy dispersive X-ray analysis which is latest thing. The author finds high status of scientific instruments in science laboratory which are the aesthetics of instrument design. The astrolabs, microscopes, telescopes and armillary spheres are beautiful objects according to the author. The equipment design provides demonstration of functionality over form and declares superfluousness of aesthetics to sci...

  3. Beautiful geometry

    CERN Document Server

    Maor, Eli

    2014-01-01

    If you've ever thought that mathematics and art don't mix, this stunning visual history of geometry will change your mind. As much a work of art as a book about mathematics, Beautiful Geometry presents more than sixty exquisite color plates illustrating a wide range of geometric patterns and theorems, accompanied by brief accounts of the fascinating history and people behind each. With artwork by Swiss artist Eugen Jost and text by acclaimed math historian Eli Maor, this unique celebration of geometry covers numerous subjects, from straightedge-and-compass constructions to intriguing configur

  4. Beauty pays but does investment in beauty?

    OpenAIRE

    Lee, Soohyung

    2015-01-01

    Being beautiful gives a person an advantage in many settings. Attractive people earn more and have an easier time getting hired. People spend large amounts of money on goods and services to enhance their beauty. Is this enhancement worth pursuing? Research suggests that the expected improvement in beauty from these goods and services is limited. Therefore, despite the large returns from having an attractive appearance, the cost-effectiveness of investment in beauty enhancement is ambiguous. F...

  5. [Therapeutic mediation tools for the benefit of the child and teenager].

    Science.gov (United States)

    Rocaboy, Claudette

    2016-01-01

    Therapeutic mediation is a tool adapted to teenagers with a chronic disease such as diabetes. Psychodrama, dramatherapy and photolanguage in particular, enable them to express themselves more freely through both speech and body, thanks to the enjoyment they get from the game, the reassurance provided by the group, the structured setting and the spontaneity they allow. PMID:26776691

  6. Beautiful asymmetry

    International Nuclear Information System (INIS)

    The LHCb experiment at CERN will allow researchers to study the difference between matter and antimatter with unprecedented accuracy, explains Roger Forty. Our current understanding of matter and forces at the subatomic scale, as embodied in the Standard Model of particle physics, is widely considered incomplete. Its most famous missing ingredient is the Higgs Boson, thought to endow all particles with mass, but there are strong indications that other pieces of the theoretical jigsaw puzzle are missing too. One of these concerns 'dark matter', the mysterious substance thought to make up more than a fifth of the universe. Postulated to account for gravitational effects that cannot be explained by the amount of visible matter alone, dark matter could be made up of exotic new particles that are not described by the Standard Model. Fortunately, there is a good chance that such particles - and the Higgs - will be created in the high-energy collisions between protons at the Large Hadron Collider (LHC). There are two approaches to discovering such new physics. The first is to try and observe the new particles directly by detecting their decay products, which will be the goal of the two giant 'general-purpose' LHC experiments ATLAS and CMS. The alternative approach is to make precision measurements of parameters that are predicted within the Standard Model and to look for deviations that could be due to as-yet-undetected particles. This is the goal of the LHCb (LHC beauty) experiment, which is dedicated to the precision study of particles that contain the bottom or beauty quark. (U.K.)

  7. Generation of mouse induced pluripotent stem cells from different genetic backgrounds using Sleeping beauty transposon mediated gene transfer.

    Science.gov (United States)

    Muenthaisong, Suchitra; Ujhelly, Olga; Polgar, Zsuzsanna; Varga, Eszter; Ivics, Zoltan; Pirity, Melinda K; Dinnyes, Andras

    2012-11-15

    Induced pluripotent stem (iPS) cell technology involves reprogramming somatic cells to a pluripotent state. The original technology used to produce these cells requires viral gene transduction and results in the permanent integration of exogenous genes into the genome. This can lead to the development of abnormalities in the derived iPS cells. Here, we report that non-viral transfection of a Sleeping Beauty (SB) transposon containing the coding sequences Oct3/4 (Pouf1), Sox-2, Klf-4 and c-Myc (OSKM) linked with 2A peptides, can reprogram mouse fibroblasts. We have established reprogrammed mouse cell lines from three different genetic backgrounds: (1) ICR-outbred, (2) C57BL/6-inbred and (3) F1-hybrid (C57BL/6 x DBA/2J), with parallel robust expression of all exogenous (Oct3/4, Sox-2, Klf-4, and c-Myc) and endogenous (e.g. Oct3/4 and Nanog) pluripotency genes. The iPS cell lines exhibited characteristics typical for undifferentiated embryonic stem (ES) cell lines: ES cell-like morphology, alkaline phosphatase (ALP) positivity and gene expression pattern (shown by reverse transcription PCR, and immunofluorescence of ES cell markers-e.g. Oct3/4, SSEA1, Nanog). Furthermore, cells were able to form embryoid bodies (EBs), to beat rhythmically, and express cardiac (assayed by immunofluorescence, e.g. cardiac Troponin T, desmin) and neuronal (assayed by immunofluorescence e.g. nestin, Tuj1) markers. The in vitro differentiation potential was found to be the highest in the ICR-derived iPS lines (ICR-iPS). Interestingly, the ICR-iPS lines had even higher differentiation potential than the ICR-ES cell lines: the rate of EBs forming rhythmically beating cardiomyocytes was 4% in ICR-ES and 79% in ICR-iPS cells, respectively. In vivo, the ICR and F1 hybrid iPS cells formed chimeras and one of the iPS cells from the F1 hybrid background transmitted to the germline. Our results suggest that iPS technology may be useful for generating pluripotent stem cells from genetic backgrounds

  8. TLR-mediated NF-kB-dependent cytokine production is differently affected by HIV therapeutics

    DEFF Research Database (Denmark)

    Melchjorsen, Jesper; Paludan, Søren Riis; Mogensen, Trine; Tolstrup, Martin; Østergaard, Lars Jørgen

      Pathogen-recognizing Toll-like receptors 2 (TLR2) and TLR4 are known to recognize a number of pathogens, including E.Coli, S. Pneumonia and N. Meningococcus. We have studied whether a number of HIV therapeutics affect immediate proinflammatory cytokine responses in cell cultures. Preliminary...... results suggest an opposing effect of the drugs Tenofovir and Retrovir (AZT) on TLR-mediated production of NF-kappaB-dependent proinflammatory cytokines. We present data on the mechanisms behind the drug-mediated remodeling of innate immune activation and how the drugs effect early host...

  9. Lentivirus-mediated gene transfer to the central nervous system: therapeutic and research applications.

    Science.gov (United States)

    Wong, Liang-Fong; Goodhead, Lucy; Prat, Christine; Mitrophanous, Kyriacos A; Kingsman, Susan M; Mazarakis, Nicholas D

    2006-01-01

    The management of disorders of the nervous system remains a medical challenge. The key goals are to understand disease mechanisms, to validate therapeutic targets, and to develop new therapeutic strategies. Viral vector-mediated gene transfer can meet these goals and vectors based on lentiviruses have particularly useful features. Lentiviral vectors can deliver 8 kb of sequence, they mediate gene transfer into any neuronal cell type, expression and therapy are sustained, and normal cellular functions in vitro and in vivo are not compromised. After delivery into the nervous system they induce no significant immune responses, there are no unwanted side effects of the vectors per se to date, and manufacturing and safety testing for clinical applications are well advanced. There are now numerous examples of effective long-term treatment of animal models of neurological disorders, such as Parkinson's disease, Alzheimer's disease, Huntington's disease, motor neuron diseases, lysosomal storage diseases, and spinal injury, using a range of therapeutic genes expressed in lentiviral vectors. Significant issues remain in some areas of neural gene therapy including defining the optimum therapeutic gene(s), increasing the specificity of delivery, regulating expression of potentially toxic genes, and designing clinically relevant strategies. We discuss the applications of lentiviral vectors in therapy and research and highlight the essential features that will ensure their translation to the clinic in the near future. PMID:16409120

  10. TERM BEAUTY IN RELIGION

    OpenAIRE

    Timchenko Mariya Stanislavovna

    2012-01-01

    The article deals with the religious approaches of the main world religions to define the term beauty. The research aim is to analyze concepts of physical and spiritual beauty in the main written religious monuments.

  11. Hypoxia-Inducible Factors: Mediators of Cancer Progression; Prognostic and Therapeutic Targets in Soft Tissue Sarcomas

    Energy Technology Data Exchange (ETDEWEB)

    Sadri, Navid; Zhang, Paul J., E-mail: pjz@mail.med.upenn.edu [Anatomic Pathology, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, 3400 Spruce Street, 6th Floor Founders Building, Philadelphia, PA 19104 (United States)

    2013-04-02

    Soft-tissue sarcomas remain aggressive tumors that result in death in greater than a third of patients due to either loco-regional recurrence or distant metastasis. Surgical resection remains the main choice of treatment for soft tissue sarcomas with pre- and/or post-operational radiation and neoadjuvant chemotherapy employed in more advanced stage disease. However, in recent decades, there has been little progress in the average five-year survival for the majority of patients with high-grade soft tissue sarcomas, highlighting the need for improved targeted therapeutic agents. Clinical and preclinical studies demonstrate that tumor hypoxia and up-regulation of hypoxia-inducible factors (HIFs) is associated with decreased survival, increased metastasis, and resistance to therapy in soft tissue sarcomas. HIF-mediated gene expression regulates many critical aspects of tumor biology, including cell survival, metabolic programming, angiogenesis, metastasis, and therapy resistance. In this review, we discuss HIFs and HIF-mediated genes as potential prognostic markers and therapeutic targets in sarcomas. Many pharmacological agents targeting hypoxia-related pathways are in development that may hold therapeutic potential for treating both primary and metastatic sarcomas that demonstrate increased HIF expression.

  12. The Real Beauty

    Institute of Scientific and Technical Information of China (English)

    胡晓媛

    2015-01-01

    it is well-known that all men search for beauty.Although the definition of beauty changes as time goes by,people still spare no efforts to pursue beauty in their lives.Meanwhile,most people try every means to make their body images better.With more people increasingly being eager for beauty in various ways,it is high time that we should think deeply about the concept of real beauty.In this paper,an attempt has been made to shed light on the real beauty.It is not completely physical appearance or slim figure,but a healthy body and peaceful mind as well as admirable courage.Above all,whether people can realize the nature of real beauty is certainly worthwhile for us to ponder.

  13. Phytochemical-mediated Protein Expression Profiling and the Potential Applications in Therapeutic Drug Target Identifications.

    Science.gov (United States)

    Wong, Fai-Chu; Tan, Siok-Thing; Chai, Tsun-Thai

    2016-07-29

    Many phytochemicals derived from edible medicinal plants have been investigated intensively for their various bioactivities. However, the detailed mechanism and their corresponding molecular targets frequently remain elusive. In this review, we present a summary of the research works done on phytochemical-mediated molecular targets, identified via proteomic approach. Concurrently, we also highlighted some pharmaceutical drugs which could be traced back to their origins in phytochemicals. For ease of presentation, these identified protein targets were categorized into two important healthcare-related fields, namely anti-bacterial and anti-cancer research. Through this review, we hope to highlight the usefulness of comparative proteomic as a powerful tool in phytochemical-mediated protein target identifications. Likewise, we wish to inspire further investigations on some of these protein targets identified over the last few years. With contributions from all researchers, the accumulative efforts could eventually lead to the discovery of some target-specific, low-toxicity therapeutic agents. PMID:26193174

  14. Therapeutic Blockade of Immune Complex-Mediated Glomerulonephritis by Highly Selective Inhibition of Bruton's Tyrosine Kinase.

    Science.gov (United States)

    Chalmers, Samantha A; Doerner, Jessica; Bosanac, Todd; Khalil, Sara; Smith, Dustin; Harcken, Christian; Dimock, Janice; Der, Evan; Herlitz, Leal; Webb, Deborah; Seccareccia, Elise; Feng, Di; Fine, Jay S; Ramanujam, Meera; Klein, Elliott; Putterman, Chaim

    2016-01-01

    Lupus nephritis (LN) is a potentially dangerous end organ pathology that affects upwards of 60% of lupus patients. Bruton's tyrosine kinase (BTK) is important for B cell development, Fc receptor signaling, and macrophage polarization. In this study, we investigated the effects of a novel, highly selective and potent BTK inhibitor, BI-BTK-1, in an inducible model of LN in which mice receive nephrotoxic serum (NTS) containing anti-glomerular antibodies. Mice were treated once daily with vehicle alone or BI-BTK-1, either prophylactically or therapeutically. When compared with control treated mice, NTS-challenged mice treated prophylactically with BI-BTK-1 exhibited significantly attenuated kidney disease, which was dose dependent. BI-BTK-1 treatment resulted in decreased infiltrating IBA-1+ cells, as well as C3 deposition within the kidney. RT-PCR on whole kidney RNA and serum profiling indicated that BTK inhibition significantly decreased levels of LN-relevant inflammatory cytokines and chemokines. Renal RNA expression profiling by RNA-seq revealed that BI-BTK-1 dramatically modulated pathways related to inflammation and glomerular injury. Importantly, when administered therapeutically, BI-BTK-1 reversed established proteinuria and improved renal histopathology. Our results highlight the important role for BTK in the pathogenesis of immune complex-mediated nephritis, and BTK inhibition as a promising therapeutic target for LN. PMID:27192942

  15. Open Beauty Production

    OpenAIRE

    Sefkow, Felix

    2001-01-01

    We review measurements of open beauty production at HERA, with emphasis on recent results based on lifetime signatures. The beauty cross sections in photoproduction and deep-inelastic scattering are found to be higher than expected in QCD at next-to-leading order. The discussion includes new results on beauty production in e+e-, gamma-gamma and p-bar-p interactions. An outlook on the potential for measurements with the upgraded HERA collider and experiments is also given.

  16. sFRP-mediated Wnt sequestration as a potential therapeutic target for Alzheimer's disease.

    Science.gov (United States)

    Warrier, Sudha; Marimuthu, Raja; Sekhar, Sreeja; Bhuvanalakshmi, G; Arfuso, Frank; Das, Anjan Kumar; Bhonde, Ramesh; Martins, Ralph; Dharmarajan, Arun

    2016-06-01

    The extracellular ligand, Wnt, and its receptors are involved in sign al transduction and play an important role in axis formation and neural development. In neurodegenerative disorders such as Alzheimer's disease (AD), a decrease of the intracellular Wnt effector, β-catenin, has been linked to amyloid-β-peptide-induced neurotoxicity. Despite this knowledge, targeting Wnt inhibitors as potential biomarkers has not been explored, and harnessing Wnt activators as therapeutic candidates remains largely not investigated. A wide acting family of Wnt mediators, secreted frizzled-related proteins (sFRPs), has not been probed so far as molecular indicators of disease occurrence and progression of Alzheimer's. Unlike the effect of the Dickkopf (DKK) family of Wnt antagonists on AD, the sFRP molecules have a more pleiotropic impact on the Wnt signaling cascade and probably have a far-reaching involvement in neurodegeneration. The role of sFRPs has been poorly described in AD, and in this review, we analyze the present status of the role of sFRPs on neurodegeneration, their likely involvement, and potential implications in treatment modalities of AD. This information would provide valuable clues for the development of potential therapeutic targets for aberrant neurodegenerative disorders. PMID:27063405

  17. Musings about Beauty

    Science.gov (United States)

    Kintsch, Walter

    2012-01-01

    In this essay, I explore how cognitive science could illuminate the concept of beauty. Two results from the extensive literature on aesthetics guide my discussion. As the term "beauty" is overextended in general usage, I choose as my starting point the notion of "perfect form." Aesthetic theorists are in reasonable agreement about the criteria for…

  18. Payments for scenic beauty

    OpenAIRE

    Jindal, Rohit; Kerr, John

    2007-01-01

    Although payments for scenic beauty are older than payment schemes for most other environmental services, scenic beauty itself is hard to define. It often encompasses a range of environmental services for consumptive (hunting, fishing) or non-consumptive (bird watching, boating) use. PES-1 (Payments for Environmental Services Associate Award)

  19. Beauty in the Breakdown

    Science.gov (United States)

    Brisco, Nicole

    2008-01-01

    Most human beings look at erosion as the destruction of a surface, but artists can see that erosion often creates indefinable beauty. Where do you see beauty in the breakdown? In this article, the author presents an innovative lesson that would allow students to observe both human and physical nature. In this activity students will create a work…

  20. Introducing 'beauty and health'

    OpenAIRE

    Edmonds, A.; Geest, van der, S.

    2009-01-01

    The authors discuss the concepts ‘beauty’ and ‘health’ and their ambiguous relationship. The quest for beauty is perceived both as an enhancement of health and well-being and as a health risk. The article is an introduction to a collection of six anthropological essays on beauty and health.

  1. Cycles of Beauty Culture: Ethnography of Beauty Clinics Commodification

    OpenAIRE

    Sri Murlianti

    2014-01-01

    Skin care is not a completely new in beauty treatments. Previously there have been other types of cultural industry which also adopted the medical science, such as cosmetic and beauty salon industries. But, skin care beauty clinic successfully introduces the services of beauty treatments which are considered the healthiest. This paper is a summary of the research on how beauty clinic quickly became a part of everyday life of its consumers. The research focused on Natasha Skin Care, a most pop...

  2. Host-Mediated Bioactivation of Pyrazinamide: Implications for Efficacy, Resistance, and Therapeutic Alternatives

    Science.gov (United States)

    Via, Laura E.; Savic, Rada; Weiner, Danielle M.; Zimmerman, Matthew D.; Prideaux, Brendan; Irwin, Scott M.; Lyon, Eddie; O’Brien, Paul; Gopal, Pooja; Eum, Seokyong; Lee, Myungsun; Lanoix, Jean-Philippe; Dutta, Noton K.; Shim, TaeSun; Cho, Jeong Su; Kim, Wooshik; Karakousis, Petros C.; Lenaerts, Anne; Nuermberger, Eric; Barry, Clifton E.; Dartois, Véronique

    2015-01-01

    Pyrazinamide has played a critical role in shortening therapy against drug-sensitive, drug-resistant, active, and latent tuberculosis (TB). Despite widespread recognition of its therapeutic importance, the sterilizing properties of this 60-year-old drug remain an enigma given its rather poor activity in vitro. Here we revisit longstanding paradigms and offer pharmacokinetic explanations for the apparent disconnect between in vitro activity and clinical impact. We show substantial host-mediated conversion of prodrug pyrazinamide (PZA) to the active form, pyrazinoic acid (POA), in TB patients and in animal models. We demonstrate favorable penetration of this pool of circulating POA from plasma into lung tissue and granulomas, where the pathogen resides. In standardized growth inhibition experiments, we show that POA exhibits superior in vitro potency compared to PZA, indicating that the vascular supply of host-derived POA may contribute to the in vivo efficacy of PZA, thereby reducing the apparent discrepancy between in vitro and in vivo activity. However, the results also raise the possibility that subinhibitory concentrations of POA generated by the host could fuel the emergence of resistance to both PZA and POA. In contrast to widespread expectations, we demonstrate good oral bioavailability and exposure in preclinical species in pharmacokinetic studies of oral POA. Baseline exposure of oral POA can be further increased by the xanthine oxidase inhibitor and approved gout drug allopurinol. These promising results pave the way for clinical investigations of oral POA as a therapeutic alternative or an add-on to overcome PZA resistance and salvage this essential TB drug. PMID:26086040

  3. Nitric oxide scavengers as a therapeutic approach to nitric oxide mediated disease.

    Science.gov (United States)

    Fricker, S P

    1999-08-01

    The essential role of nitric oxide (NO) in normal physiology and its involvement in the pathophysiology of a variety of diseases render the compound an attractive therapeutic target. NO donor drugs are used in the treatment of hypotension and angina where abnormalities in the L-arginine-nitric oxide pathway have been implicated. Overproduction of NO has been associated with a number of disease states including septic shock, inflammatory diseases, diabetes, ischaemia-reperfusion injury, adult respiratory distress syndrome, neurodegenerative diseases and allograft rejection. NO is produced by a group of enzymes, the nitric oxide synthases. Selective inhibition of the inducible isoform is one approach to the treatment of diseases where there is an overproduction of NO; an alternative approach is to scavenge or remove excess NO. A number of NO scavenger molecules have demonstrated pharmacological activity in disease models, particularly models of septic shock. These include organic molecules such as PTIO (2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide), haemoglobin derivatives such as the pyridoxalated haemoglobin polyoxyethylene conjugate (PHP), low molecular weight iron compounds of diethylenetriaminepentaacetic acid and diethyldithiocarbamate and ruthenium polyaminocarboxylate complexes. The data suggest a potential role for NO scavengers in the treatment of NO mediated disease. PMID:15992146

  4. Nrf2/ARE Signaling Pathway: Key Mediator in Oxidative Stress and Potential Therapeutic Target in ALS

    Directory of Open Access Journals (Sweden)

    Susanne Petri

    2012-01-01

    Full Text Available Nrf2 (nuclear erythroid 2-related factor 2 is a basic region leucine-zipper transcription factor which binds to the antioxidant response element (ARE and thereby regulates the expression of a large battery of genes involved in the cellular antioxidant and anti-inflammatory defence as well as mitochondrial protection. As oxidative stress, inflammation and mitochondrial dysfunctions have been identified as important pathomechanisms in amyotrophic lateral sclerosis (ALS, this signaling cascade has gained interest both with respect to ALS pathogenesis and therapy. Nrf2 and Keap1 expressions are reduced in motor neurons in postmortem ALS tissue. Nrf2-activating compounds have shown therapeutic efficacy in the ALS mouse model and other neurodegenerative disease models. Alterations in Nrf2 and Keap1 expression and dysregulation of the Nrf2/ARE signalling program could contribute to the chronic motor neuron degeneration in ALS and other neurodegenerative diseases. Therefore, Nrf2 emerges as a key neuroprotective molecule in neurodegenerative diseases. Our recent studies strongly support that the Nrf2/ARE signalling pathway is an important mediator of neuroprotection and therefore represents a promising target for development of novel therapies against ALS, Parkinson’s disease (PD, Huntington’s disease (HD, and Alzheimer’s disease (AD.

  5. Beauty in chemistry

    Directory of Open Access Journals (Sweden)

    Peter Atkins

    2006-03-01

    Full Text Available Though hard going for the general reader and highly personal in its selectivity, Elegant Solutions: Ten Beautiful Experiments in Chemistry provides reflections of a thoughtful author that will delight chemists

  6. Beauty in chemistry

    OpenAIRE

    Peter Atkins

    2006-01-01

    Though hard going for the general reader and highly personal in its selectivity, Elegant Solutions: Ten Beautiful Experiments in Chemistry provides reflections of a thoughtful author that will delight chemists

  7. Conference Summary - Beauty 2000

    OpenAIRE

    Stone, Sheldon

    2000-01-01

    Comment: 19 pages, 8 figures; to be published in Proceedings of Beauty 2000, Kibbutz Maagan, Israel, September, 2000, edited by S. Erhan, Y. Rozen, and P. E. Schlein, Nucl. Inst. Meth. A, 2001. Corrected references

  8. What Is Beauty?

    Institute of Scientific and Technical Information of China (English)

    胡应余

    2007-01-01

    <正> It seems that beauty and women are twins. You are joking? No, I am not. Observe for yourself. Ads on fashion flood TV screens, radio programs, magazines, newspapers, and the streets. Whether they have realized or not, women are besieged by a sea of fashions. They are taught to think that without beautiful clothes they will grow old and lose their charm. So who dares to neglect dressing up at the cost of their appearance and youth?

  9. The medicalization of beauty

    OpenAIRE

    Paulo Poli Neto; Sandra N.C. Caponi; Silvana Polchlopek

    2007-01-01

    Concern with body image and medical interventions related to physical beauty has greatly increased in the past few years. The purpose of this study is to investigate how medicine is dealing with the theme of beauty. The 2003/2004 editions of the periodicals Aesthetic Surgery Journal and Aesthetic Plastic Surgery were analyzed, in order to investigate the rationality buttressing their discourse. Three categories were prioritized for this study: definition of aesthetic plastic surgery's study o...

  10. BEAUTY'99 Conference Summary

    OpenAIRE

    Eerola, P.

    1999-01-01

    Investigations of B hadrons are expected to break new ground in measuring CP-violation effects. This series of BEAUTY conferences, originating from the 1993 conference in Liblice, has contributed significantly in developing ideas of CP-violation measurements using B hadrons and formulating and comparing critically the B-physics experiments. In the '99 conference in Bled we saw the ripening of the field and the first fruit emerging - Tevatron have produced beautiful B-physics results and more ...

  11. Beauty at the LHC

    OpenAIRE

    Pich, Antonio; Prades, Joaquim

    1990-01-01

    The LHC is expected to produce unprecedented amounts of pairs of beautiful particles. A high energy hadron collider is arguably the only machine sufficiently luminous to analyse CP violation in the B—sector, and to discover particles that are both charmed and beautiful. In a collider mode the main difficulty, that we discuss at length, is the extraction of the signal from the humongous backgrounds. We offer commentary on the comparison with a fixed targed mode of operation and with other mach...

  12. Chinese Beauty Rules

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Beijing beauty Zhang Zilin walked away with the Miss World 2007 crown before a partisan crowd on December 1,daz- zling the judging panel with her high-voltage smile and elegant confidence. The 23-year-old Miss China set the night alight in Sanya,in south China’s Hainan Province,when she emerged from a bevy of 106 of the world’s most beautiful women to become China’s first Miss World in 57 years

  13. Utilizing redox-mediated Bergman cyclization toward the development of dual-action metalloenediyne therapeutics.

    Science.gov (United States)

    Lindahl, Sarah E; Park, Hyunsoo; Pink, Maren; Zaleski, Jeffrey M

    2013-03-13

    Reaction of 2 equiv of 1,2-bis((diphenylphosphino)ethynyl)benzene (dppeb, 1) with Pt(cod)Cl2 followed by treatment with N2H4 yields the reduced Pt(0) metalloenediyne, Pt(dppeb)2, 2. This complex is stable to both air oxidation and metal-mediated Bergman cyclization under ambient conditions due to the nearly idealized tetrahedral geometry. Reaction of 2 with 1 equiv of I2 in the presence of excess 1,4-cyclohexadiene (1,4-CHD) radical trap rapidly and near-quantitatively generates the cis-Bergman-cyclized, diiodo product 3 ((31)P: δ = 41 ppm, J(Pt-P) = 3346 Hz) with concomitant loss of 1 equiv of uncyclized phosphine chelate ((31)P: δ = -33 ppm). In contrast, addition of 2 equiv of I2 in the absence of additional radical trap instantaneously forms a metastable Pt(dppeb)2(2+) intermediate species, 4, that is characterized by δ = 51 ppm in the (31)P NMR (J(Pt-P) = 3171 Hz) and ν(C≡C) = 2169 cm(-1) in the Raman profile, indicating that it is an uncyclized, bis-ligated complex. Over 24 h, 4 undergoes ligand exchange to form a neutral, square planar complex that spontaneously Bergman cyclizes at ambient temperature to give the crystalline product Pt(dppnap-I2)I2 (dppnap-I2 = (1,4-diiodonaphthalene-2,3-diyl)bis(diphenylphosphine)), 5, in 52% isolated yield. Computational analysis of the oxidation reaction proposes two plausible flattened tetrahedral structures for intermediate 4: one where the phosphine core has migrated to a trans-spanning chelate geometry, and a second, higher energy structure (3.3 kcal/mol) with two cis-chelating phosphine ligands (41° dihedral angle) via a restricted alkyne-terminal starting point. While the energies are disparate, the common theme in both structures is the elongated Pt-P bond lengths (>2.4 Å), indicating that nucleophilic ligand substitution by I(-) is on the reaction trajectory to the cyclized product 5. The efficiency of the redox-mediated Bergman cyclization reaction of this stable Pt(0) metalloenediyne prodrug and

  14. Therapeutic impact of systemic AAV-mediated RNA interference in a mouse model of myotonic dystrophy.

    Science.gov (United States)

    Bisset, Darren R; Stepniak-Konieczna, Ewa A; Zavaljevski, Maja; Wei, Jessica; Carter, Gregory T; Weiss, Michael D; Chamberlain, Joel R

    2015-09-01

    RNA interference (RNAi) offers a promising therapeutic approach for dominant genetic disorders that involve gain-of-function mechanisms. One candidate disease for RNAi therapy application is myotonic dystrophy type 1 (DM1), which results from toxicity of a mutant mRNA. DM1 is caused by expansion of a CTG repeat in the 3' UTR of the DMPK gene. The expression of DMPK mRNA containing an expanded CUG repeat (CUG(exp)) leads to defects in RNA biogenesis and turnover. We designed miRNA-based RNAi hairpins to target the CUG(exp) mRNA in the human α-skeletal muscle actin long-repeat (HSA(LR)) mouse model of DM1. RNAi expression cassettes were delivered to HSA(LR) mice using recombinant adeno-associated viral (rAAV) vectors injected intravenously as a route to systemic gene therapy. Vector delivery significantly reduced disease pathology in muscles of the HSA(LR) mice, including a reduction in the CUG(exp) mRNA, a reduction in myotonic discharges, a shift toward adult pre-mRNA splicing patterns, reduced myofiber hypertrophy and a decrease in myonuclear foci containing the CUG(exp) mRNA. Significant reversal of hallmarks of DM1 in the rAAV RNAi-treated HSA(LR) mice indicate that defects characteristic of DM1 can be mitigated with a systemic RNAi approach targeting the nuclei of terminally differentiated myofibers. Efficient rAAV-mediated delivery of RNAi has the potential to provide a long-term therapy for DM1 and other dominant muscular dystrophies. PMID:26082468

  15. Ultrasound-mediated oncolytic virus delivery and uptake for increased therapeutic efficacy: state of art

    Directory of Open Access Journals (Sweden)

    Nande R

    2015-11-01

    Full Text Available Rounak Nande,1 Candace M Howard,2 Pier Paolo Claudio,3,4 1Department of Biochemistry and Microbiology, Marshall University School of Medicine, Huntington, WV, 2Department of Radiology, University of Mississippi Medical Center, Jackson, MS, 3Department of BioMolecular Sciences and National Center for Natural Products Research, School of Pharmacy, University of Mississippi, MS, 4Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, MS, USA Abstract: The field of ultrasound (US has changed significantly from medical imaging and diagnosis to treatment strategies. US contrast agents or microbubbles (MB are currently being used as potential carriers for chemodrugs, small molecules, nucleic acids, small interfering ribonucleic acid, proteins, adenoviruses, and oncolytic viruses. Oncolytic viruses can selectively replicate within and destroy a cancer cell, thus making them a powerful therapeutic in treating late-stage or metastatic cancer. These viruses have been shown to have robust activity in clinical trials when injected directly into tumor nodules. However limitations in oncolytic virus’ effectiveness and its delivery approach have warranted exploration of ultrasound-mediated delivery. Gene therapy bearing adenoviruses or oncolytic viruses can be coupled with MBs and injected intravenously. Following application of US energy to the target region, the MBs cavitate, and the resulting shock wave enhances drug, gene, or adenovirus uptake. Though the underlying mechanism is yet to be fully understood, there is evidence to suggest that mechanical pore formation of cellular membranes allows for the temporary uptake of drugs. This delivery method circumvents the limitations due to stimulation of the immune system that prevented intravenous administration of viruses. This review provides insight into this intriguing new frontier on the delivery of oncolytic viruses to tumor sites.Keywords: microbubbles, ultrasound

  16. Therapeutic effects of lentivirus-mediated shRNA targeting of cyclin D1 in human gastric cancer

    International Nuclear Information System (INIS)

    Gastric cancer is the second most common cause of cancer-related death in males and the fourth in females. Traditional treatment has poor prognosis because of recurrence and systemic side effects. Therefore, the development of new therapeutic strategies is an important issue. Lentivirus-mediated shRNA stably inhibits target genes and can efficiently transduce most cells. Since overexpressed cyclin D1 is closely related to human gastric cancer progression, inhibition of cyclin D1 using specific targeting could be an effective treatment method of human gastric cancer. The therapeutic effect of lentivirus-mediated shRNA targeting of cyclin D1 (ShCCND1) was analyzed both in vitro and in vivo experiments. In vitro, NCI-N87 cells with downregulation of cyclin D1 by ShCCND1 showed significant inhibition of cell proliferation, cell motility, and clonogenicity. Downregulation of cyclin D1 in NCI-N87 cells also resulted in significantly increased G1 arrest and apoptosis. In vivo, stable NCI-N87 cells expressing ShCCND1 were engrafted into nude mice. Then, the cancer-growth inhibition effect of lentivirus was confirmed. To assess lentivirus including ShCCND1 as a therapeutic agent, intratumoral injection was conducted. Tumor growth of the lentivirus-treated group was significantly inhibited compared to growth of the control group. These results are in accordance with the in vitro data and lend support to the mitotic figure count and apoptosis analysis of the tumor mass. The lentivirus-mediated ShCCND1 was constructed, which effectively inhibited growth of NCI-N87-derived cancer both in vitro and in vivo. The efficiency of shRNA knockdown and variation in the degree of inhibition is mediated by different shRNA sequences and cancer cell lines. These experimental results suggest the possibility of developing new gastric cancer therapies using lentivirus-mediated shRNA

  17. Why Landscape Beauty Matters

    Directory of Open Access Journals (Sweden)

    Angelika Krebs

    2014-11-01

    Full Text Available This philosophical paper explores the aesthetic argument for landscape conservation. The main claim is that the experience of beautiful landscapes is an essential part of the good human life. Beautiful landscapes make us feel at home in the world. Their great and irreplaceable value lies therein. To establish this claim, the concepts of landscape and “Stimmung” are clarified. It is shown how “Stimmung” (in the sense of mood is infused into landscape (as atmosphere and how we respond to it aesthetically. We respond by resonating or feeling at home. The paper ends by indicating how art can help us to better appreciate landscape beauty. This is done by way of an example from contemporary nature poetry, Michael Donhauser’s Variationen in Prosa, which begins with “Und was da war, es nahm uns an” (“And what was there accepted us”.

  18. Who Engages with Moral Beauty?

    Science.gov (United States)

    Diessner, Rhett; Iyer, Ravi; Smith, Meghan M.; Haidt, Jonathan

    2013-01-01

    Aristotle considered moral beauty to be the "telos" of the human virtues. Displays of moral beauty have been shown to elicit the moral emotion of elevation and cause a desire to become a better person and to engage in prosocial behavior. Study 1 ("N" = 5380) shows engagement with moral beauty is related to several psychological…

  19. Introduction to Beautiful Soup

    OpenAIRE

    Jeri Wieringa

    2012-01-01

    Beautiful Soup is a Python library for getting data out of HTML, XML, and other markup languages. Say you’ve found some webpages that display data relevant to your research, such as date or address information, but that do not provide any way of downloading the data directly. Beautiful Soup helps you pull particular content from a webpage, remove the HTML markup, and save the information. It is a tool for web scraping that helps you clean up and parse the documents you have pulled down from t...

  20. Why Beauty Matters

    OpenAIRE

    Rosenblat, Tanya; Mobius, Markus

    2006-01-01

    We decompose the beauty premium in an experimental labor market where “employers†determine wages of “workers†who perform a maze-solving task. This task requires a true skill which we show to be unaffected by physical attractiveness. We find a sizable beauty premium and can identify three transmission channels: (a) physically attractive workers are more confident and higher confidence increases wages; (b) for a given level of confidence, physically attractive workers are (wrongly) cons...

  1. Beauty in Hume's Viewpoint

    OpenAIRE

    Ali Salmani

    2010-01-01

    Although Hume, regarding his basic ideas, explicitly identifies beauty as a sentiment, but in some passages it is introduced not as a sentiment but as a real quality. In some other passages, it also seemed like a secondary quality. Some interpreters, just by referring to these unclear passages in Hume’s writings, offered a kind of interpretations from Hume’s basic idea of beauty that finally is incompatible with his entire philosophy. We attempt, in this paper, by presenting the Hume’s theory...

  2. Introduction to Beautiful Soup

    Directory of Open Access Journals (Sweden)

    Jeri Wieringa

    2012-12-01

    Full Text Available Beautiful Soup is a Python library for getting data out of HTML, XML, and other markup languages. Say you’ve found some webpages that display data relevant to your research, such as date or address information, but that do not provide any way of downloading the data directly. Beautiful Soup helps you pull particular content from a webpage, remove the HTML markup, and save the information. It is a tool for web scraping that helps you clean up and parse the documents you have pulled down from the web.

  3. Clinical study on safety and immunogenicity of therapeutic dual-plasmid HBV DNA vaccine mediated by in vivo electroporation

    Directory of Open Access Journals (Sweden)

    Hai-yan YANG

    2013-03-01

    Full Text Available Objective  To evaluate the safety and immunogenicity of the therapeutic dual-plasmid HBV DNA vaccine mediated by electroporation (EP in vivo against the hepatitis B virus in healthy adult volunteers. Methods The enrolled 30 healthy volunteers were randomly divided into three dosage groups (10 volunteers in each group, namely: high-dose (4mg, middle-dose (2mg and low-dose (1mg groups. Volunteers received four intramuscular injections of HBV DNA vaccine mediated by in vivo EP at the 0, 4th, 12th and 24th week. Each dose group was further divided into 2 sub-groups (5 persons/per group with different EP frequencies, i.e. 36 and 60 volt. The changes in response was determined by physical diagnosis (ECG, chest X-ray, type-B ultrasound, lab findings (blood and urine routine, blood biochemistry, prothrombin time, thyroid function, tumor biomarkers, immunological variables (IFN-γ, ANA, anti-dsDNA Ab, serological variables pertaining to HBV (HBsAg, HBcAb, HBeAg, HBeAb, HBV DNA and serum anti-HBs status in volunteers before and after receiving EP mediated HBV DNA vaccination. Results The dual-plasmid HBV DNA vaccination mediated by in vivo EP was well tolerated in all healthy volunteers with a stable life signs. It was found that EP-mediated immunization of the therapeutic DNA vaccine against hepatitis B virus had a specific and obvious anti-HBs humoral immune response in one volunteer (17.22mU/ml. Four repeated intramuscular injections of the vaccine did not show any significant adverse effects in the receptors. Although mild elevation of serum ALT and enlarged spleen were found in one individual, the abnormalities disappeared spontaneously at the end of the trial. Conclusions EP-mediated dual-plasmid HBV DNA vaccine is safe and well tolerated with certain degree of humoral immunogenicity.

  4. The Beauty of Forecasting

    OpenAIRE

    David Orrell

    2014-01-01

    In a 2009 news article entitled ÒHow Did Economists Get It So Wrong?,Ó Paul Krugman wrote, ÒThe economics profession went astray because economists, as a group, mistook beauty, clad in impressive- looking mathematics, for truth.Ó In this article, David Orrell asks if the same could be said of forecasters. Copyright International Institute of Forecasters, 2014

  5. Spectroscopy of beautiful baryons

    Energy Technology Data Exchange (ETDEWEB)

    Caloi, R.; Gentile, S.; Mignani, R. (Rome Univ. (Italy). Ist. di Fisica)

    1980-09-20

    By assuming a non-relativistic quark model, an estimate of the masses of the low-lying (non-strange and non-charmed) beautiful baryons is given. Electromagnetic mass splittings of the same baryons are also discussed in some detail.

  6. A Window of Beauty

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Yan Hong (front, third from the right), Mr Leo Passage, President of Pivot Point (front, second from the right) and Peng Jinzhao, President of Pivot Point—Asia Region (front, fourth from the right) with the students of the Sichuan Pivot Point Beauty Institute.

  7. Lesbians discuss beauty and aging.

    Science.gov (United States)

    Thompson, K M; Brown, N; Cassidy, J; Gentry, J H

    1999-01-01

    ABSTRACT Two conversations with three aging lesbians are presented to identify and explore different definitions of beauty and how these definitions change and are influenced by age. The three women interviewed believe beauty is more than skin deep, yet they differ regarding specific components of beauty. Two believe that their definition of beauty has changed as they age and one believes that her definition has remained basically unchanged through the years. Topics of discussion include: beauty role models, the impact of the American beauty standard on their self-esteem, and what they look for in potential partners. Through these women's diverse opinions on how beauty is defined and experienced by older lesbians, we see that there is no one perspective representing all older women. PMID:24786423

  8. ON BEAUTY AND THE BEAUTIFUL IN AESTHETIC EDUCATION

    Directory of Open Access Journals (Sweden)

    Borce Kostov

    2013-06-01

    Full Text Available We titled our work “On Beauty and the Beautiful in Aesthetic Education” and we analyzed the category beautiful in function of better understanding the issues of aesthetic education.The basic point was the fact that the determination of the term beautiful is being different in both, time aspect and space aspect. Also, the authors involved in this matter have got different understanding on beautiful issue, on its essence, on its role in human development and on the development of the aesthetics and the aesthetic education.Therefore, within our work, there is an attempt to differ the approaches towards the category beautiful, to comment it, to compare it and finally to give our approach.

  9. The face, beauty, and symmetry: perceiving asymmetry in beautiful faces.

    Science.gov (United States)

    Zaidel, D W; Cohen, J A

    2005-08-01

    The relationship between bilateral facial symmetry and beauty remains to be clarified. Here, straight head-on photographs of "beautiful" faces from the collections of professional modeling agencies were selected. First, beauty ratings were obtained for these faces. Then, the authors created symmetrical left-left and right-right composites of the beautiful faces and asked a new group of subjects to choose the most attractive pair member. "Same" responses were allowed. No difference between the left-left and right-right composites was revealed but significant differences were obtained between "same" and the left-left or right-right. These results show that subjects detected asymmetry in beauty and suggest that very beautiful faces can be functionally asymmetrical. PMID:16040358

  10. The face, beauty, and symmetry: Perceiving asymmetry in beautiful faces

    OpenAIRE

    Zaidel, Dr. Dahlia W.; Cohen, Jennifer A.

    2005-01-01

    The relationship between bilateral facial symmetry and beauty remains to be clarified. Here, straight head-on photographs of “beautiful” faces from the collections of professional modeling agencies were selected. First, beauty ratings were obtained for these faces. Then, the authors created symmetrical left-left and right-right composites of the beautiful faces and asked a new group of subjects to choose the most attractive pair member. “Same” responses were allowed. No difference between the...

  11. Burns and beauty nails

    Science.gov (United States)

    Bélanger, Richard E; Marcotte, Marie-Eve; Bégin, François

    2013-01-01

    A case involving a five-month-old girl brought to the emergency department with burns over her abdomen is described. The child was reported to have spilled two small bottles of beauty nail adhesive on her clothes while her mother was preparing dinner. After undressing the infant, the mother discovered several lesions on the child’s abdomen and quickly sought medical attention. Given the unusual circumstances of the presentation, the child was hospitalized for both treatment and supervision. The beauty nail adhesive contained cyanoacrylate. In addition to its well-appreciated adhesive capacity, cyanoacrylate, in the presence of cotton or other tissues, is known to produce an exothermic reaction that may cause burns. Cyanoacrylate-based products, due to their possible adverse effects, should be kept away from children as advised. Odd injuries should always raise concerns about the possibility of inflicted injury. PMID:24421671

  12. Burns and beauty nails

    OpenAIRE

    Richard E. Bélanger; Marcotte, Marie-Eve; Bégin, François

    2013-01-01

    A case involving a five-month-old girl brought to the emergency department with burns over her abdomen is described. The child was reported to have spilled two small bottles of beauty nail adhesive on her clothes while her mother was preparing dinner. After undressing the infant, the mother discovered several lesions on the child’s abdomen and quickly sought medical attention. Given the unusual circumstances of the presentation, the child was hospitalized for both treatment and supervision. T...

  13. Shibusa: extracting beauty

    OpenAIRE

    Adkins, Monty; Dickens, Pip

    2012-01-01

    Shibusa – Extracting Beauty celebrates a number of artistic endeavours: music, painting and the skill of making in general with particular reflection upon Japanese aesthetics. Composer, Monty Adkins and visual artist, Pip Dickens (through a Leverhulme Trust Award collaboration) investigate commonality and difference between the visual arts and music exploring aspects of rhythm, pattern, colour and vibration as well as outlining processes utilised to evolve new works within these practic...

  14. Sublimity, beauty and decorum

    OpenAIRE

    White, Luke

    2007-01-01

    This catalogue essay examines the work of two contemporary abstract painters, Maisie Kendall and Richmond Burton, who were showing together at the Royal Academy Schools Gallery in London, in Autumn 2007. It traces the fate of the "decorative" in modern art, and relates this term to Neoclassical attitudes to decorum. Tracing the turn away from decorum as a validating term in art, with the rise of the related (and gendered) notions of the sublime and the beautiful (with the privileging of the f...

  15. Politics of Beauty

    OpenAIRE

    Ken-ichi Sasaki

    2011-01-01

    I look back at the history of modern aesthetics to grasp its current situation and to propose its possibilities for the future. The early modern period, during which aesthetics came into being, was a great historical turning point for civilization. Our contemporary period shares this character, and it is worthwhile for us to consult its history in order to reflect on our civilization. Aesthetics began with Baumgarten’s proposal, which consisted in a triple subject: sensibility, beauty, an...

  16. A Beautiful Spin

    International Nuclear Information System (INIS)

    Spin is a beautiful concept that plays an ever important role in modern physics. In this talk, I start with a discussion of the origin of spin, and then turn to three themes in which spin has been crucial in subatomic physics: a lab to explore physics beyond the standard model, a tool to measure physical observables that are hard to obtain otherwise, a probe to unravel nonperturbative QCD. I conclude with some remarks on a world without spin

  17. A beautiful theory

    OpenAIRE

    Ed Nosal; Peter Rupert

    2002-01-01

    It wasn’t A Beautiful Mind—the book or the movie—that made John Forbes Nash, Jr., famous. It was his work in game theory, a theory that models strategic interactions between people as games. Before Nash, the only games theorists could get a handle on were artificial ones with no real-world applications. Nash’s insights enabled economists to expand the use of game theory to interesting practical problems.

  18. Small is beautiful

    Energy Technology Data Exchange (ETDEWEB)

    Schumacher, E.F.

    1973-01-01

    The author feels that ''an almost universal idolatry of gigantism'' has caused the urgent crisis of today's society. The book expresses his philosophy of the beauty of thinking in less grandiose terms. He offers some smaller-scale yet highly feasible solutions to many of the problems created by bigness--the environmental crisis, the energy shortage, the dehumanization of industrial workers, the flight from rural areas, and the decay of cities. (MCW)

  19. Two beautiful new particles

    CERN Multimedia

    Antonella Del Rosso

    2012-01-01

    In beautiful agreement with the Standard Model, two new excited states (see below) of the Λb beauty particle have just been observed by the LHCb Collaboration. Similarly to protons and neutrons, Λb is composed of three quarks. In the Λb’s case, these are up, down and… beauty.   Although discovering new particles is increasingly looking like a routine exercise for the LHC experiments (see previous features), it is far from being an obvious performance, particularly when the mass of the particles is high. Created in the high-energy proton-proton collisions produced by the LHC, these new excited states of the Λb particle have been found to have a mass of, respectively, 5912 MeV/c2 and 5920 MeV/c2. In other words, they are over five times heavier than the proton or the neutron. Physicists only declare a discovery when data significantly show the relevant signal. In order to do that, they often have to analyse large samples of data. To ...

  20. Preasymptotic effects in beauty decays

    OpenAIRE

    Guberina, B.; Melic, B.; Stefancic, H.

    2000-01-01

    Large preasymptotic effects in beauty decays have been found using heavy-quark and SU(3) symmetry, as well as experimental data on charmed hyperons. Contrary to rather uniform beauty-meson lifetimes, a much larger spread of beauty-baryon lifetimes is predicted. However, it is highly unlikely that, theoretically, the $ \\tau(\\Lambda_b)/\\tau(B_d^0) $ ratio, which at present deviates more than $1\\sigma$ from the experimental result, can be lowered below 0.9.

  1. Hadroproduction of Charm and Beauty

    OpenAIRE

    Karchin, Paul E.

    1997-01-01

    Recent results on the hadroproduction of charm and beauty are discussed in the context of the current theoretical and experimental status. The areas covered include production of open charm and beauty particles and charm and beauty quarkonia. Experimental results from both fixed target and colliding beam experiments are presented and compared to theoretical predictions. Predictions based on QCD perturbation theory are generally successful in explaining the shapes of differential cross section...

  2. Therapeutic Blockade of Immune Complex-Mediated Glomerulonephritis by Highly Selective Inhibition of Bruton’s Tyrosine Kinase

    Science.gov (United States)

    Chalmers, Samantha A.; Doerner, Jessica; Bosanac, Todd; Khalil, Sara; Smith, Dustin; Harcken, Christian; Dimock, Janice; Der, Evan; Herlitz, Leal; Webb, Deborah; Seccareccia, Elise; Feng, Di; Fine, Jay S.; Ramanujam, Meera; Klein, Elliott; Putterman, Chaim

    2016-01-01

    Lupus nephritis (LN) is a potentially dangerous end organ pathology that affects upwards of 60% of lupus patients. Bruton’s tyrosine kinase (BTK) is important for B cell development, Fc receptor signaling, and macrophage polarization. In this study, we investigated the effects of a novel, highly selective and potent BTK inhibitor, BI-BTK-1, in an inducible model of LN in which mice receive nephrotoxic serum (NTS) containing anti-glomerular antibodies. Mice were treated once daily with vehicle alone or BI-BTK-1, either prophylactically or therapeutically. When compared with control treated mice, NTS-challenged mice treated prophylactically with BI-BTK-1 exhibited significantly attenuated kidney disease, which was dose dependent. BI-BTK-1 treatment resulted in decreased infiltrating IBA-1+ cells, as well as C3 deposition within the kidney. RT-PCR on whole kidney RNA and serum profiling indicated that BTK inhibition significantly decreased levels of LN-relevant inflammatory cytokines and chemokines. Renal RNA expression profiling by RNA-seq revealed that BI-BTK-1 dramatically modulated pathways related to inflammation and glomerular injury. Importantly, when administered therapeutically, BI-BTK-1 reversed established proteinuria and improved renal histopathology. Our results highlight the important role for BTK in the pathogenesis of immune complex-mediated nephritis, and BTK inhibition as a promising therapeutic target for LN. PMID:27192942

  3. Investigations by Cell-Mediated Immunologic Tests and Therapeutic Trials With Thymopentin in Vaginal Mycoses

    OpenAIRE

    Werner Mendling; Ursula Koldovsky

    1996-01-01

    Objective: According to unsatisfactory therapeutic results in patients with chronically recurrent vaginal candidosis, we investigated if immunologic patient factors could be found and treated. Methods: In 42 women with chronically recurrent and 20 women with acute Candida albicans vulvovaginitis, as well as 14 women with C. glabrata vaginitis, the following investigations were carried out: identification of yeast species; quantification of T lymphocytes and their subpopulations in sera; proli...

  4. Enhanced immunity in a mouse model of malignant glioma is mediated by a therapeutic ketogenic diet

    OpenAIRE

    Lussier, Danielle M.; Woolf, Eric C.; Johnson, John L.; Brooks, Kenneth S.; Blattman, Joseph N.; Scheck, Adrienne C.

    2016-01-01

    Background Glioblastoma multiforme is a highly aggressive brain tumor with a poor prognosis, and advances in treatment have led to only marginal increases in overall survival. We and others have shown previously that the therapeutic ketogenic diet (KD) prolongs survival in mouse models of glioma, explained by both direct tumor growth inhibition and suppression of pro-inflammatory microenvironment conditions. The aim of this study is to assess the effects of the KD on the glioma reactive immun...

  5. Autistic functioning and therapeutical dimension of mediations (Tome 1 and 2)

    OpenAIRE

    Chocron, Michael

    2012-01-01

    Care for subjects with autistic or related disorders in medical institutes is mainly based on activities using mediation. This research deals with the caring of youngsters with Pervasive Developmental Disorder in a medical institute. Using both autobiographical work from author with autism and case study of psychotherapeutic follow-up in a medical institute, the idea of autistic functioning will be exposed. This idea is a way to comprehend psychic process mostly seen in autistic persons. In a...

  6. Recognition-mediated activation of therapeutic gold nanoparticles inside living cells

    Science.gov (United States)

    Kim, Chaekyu; Agasti, Sarit S.; Zhu, Zhengjiang; Isaacs, Lyle; Rotello, Vincent M.

    2010-11-01

    Supramolecular chemistry provides a versatile tool for the organization of molecular systems into functional structures and the actuation of these assemblies for applications through the reversible association between complementary components. Use of this methodology in living systems, however, represents a significant challenge owing to the chemical complexity of cellular environments and lack of selectivity of conventional supramolecular interactions. Herein, we present a host-guest system featuring diaminohexane-terminated gold nanoparticles (AuNP-NH2) and complementary cucurbit[7]uril (CB[7]). In this system, threading of CB[7] on the particle surface reduces the cytotoxicity of AuNP-NH2 through sequestration of the particle in endosomes. Intracellular triggering of the therapeutic effect of AuNP-NH2 was then achieved through the administration of 1-adamantylamine (ADA), removing CB[7] from the nanoparticle surface, causing the endosomal release and concomitant in situ cytotoxicity of AuNP-NH2. This supramolecular strategy for intracellular activation provides a new tool for potential therapeutic applications.

  7. Beauty and Testimony

    OpenAIRE

    Hopkins, Robert

    2000-01-01

    I ask whether, and how far, it is possible legitimately to acquire the belief that a given item is beautiful on the basis of someone's testimony that it is. This is an issue that concerned Kant. Kant held that testimony could never be a legitimate source of such judgements, and clearly took his account of aesthetic judgement to explain this fact. I argue that Kant's theory does not, in fact, provide the materials for a satisfactory explanation. Was Kant at least right about the explanadum? Wh...

  8. A Corporate Beauty Contest

    OpenAIRE

    Graham, John R.; Campbell R. Harvey; Manju Puri

    2010-01-01

    We conduct beauty contest experiments, using close to 2,000 subjects to study the facial traits of CEOs. In one experiment we use pairs of photographs and find that subjects rate CEO faces as appearing more "competent" and less "likable" than non-CEO faces. Another experiment matches CEOs from large firms against CEOs from smaller firms and finds large-firm CEOs look more competent and likable. In a third experiment, subjects numerically rate the facial traits of CEOs. We find that executive ...

  9. Beauty97 Conference Summary

    OpenAIRE

    Erhan, Samim

    1998-01-01

    CP-violation is one of the least understood phenomena in our field. There are major experimental programs in all high energy laboratories around the world which will hopefully remedy this within the next decade. The study of CP-violating effects in B meson decays will allow stringent tests of the Standard Model to be made and may point the way to New Physics. The Beauty97 conference provided a forum for these experiments to discuss their physics potential and experimental challenges relating ...

  10. Theory of Beauty Lifetimes

    OpenAIRE

    Neubert, Matthias(PRISMA Cluster of Excellence and Mainz Institut for Theoretical Physics, Johannes Gutenberg University, 55099, Mainz, Germany)

    1997-01-01

    A critical review of the theoretical understanding of the lifetimes of beauty hadrons is given. A model-independent analysis using the heavy-quark expansion allows for a description of the lifetime ratios tau(B-)/tau(B0) and tau(Lambda_b)/tau(B0) in a small region of parameter space. It is demonstrated that the lifetime ratio tau(B-)/tau(B0) cannot be used to extract the decay constant of the B meson. Implications for the semileptonic branching ratio and charm yield in B decays are pointed out.

  11. A Beautiful Story

    Science.gov (United States)

    García-Moliner, Federico

    In 1981, a time when our science administrators still believed that small is beautiful, I was sent to Cuba with a very simple mission: To establish contact with the solid state physicists at the University of Havana in order to identify affinities and prepare the ground for possible collaborations. I count this as one of the most fortunate events in my professional and human experience. It marked the beginning of a long lasting and very fruitful collaboration as well as of many brotherly friendships that have significantly contributed to the enrichment of my life as a human being.

  12. She Looks so Beautiful

    OpenAIRE

    Karen de Kock

    2008-01-01

    This article offers a story that illustrates how the medium of music is able to provide comfort, even in extreme cases of hopelessness, when all other efforts seem futile. I will relate how the creative act of music-making within an institutional setting, was able to provide comfort to a self-injurious female psychiatric client, who had been institutionalised all her life, to restore a sense of beauty and dignity which had been lost. The music that was created in the moment was also able to c...

  13. Escaping Beauty through moral narratives

    DEFF Research Database (Denmark)

    Sloth, Erik

    2010-01-01

    This study investigate through ethnographic studies the shared cultural meanings expressed about human beauty. How is sense making about the notion of beauty constructed, verballized and negotiated in a group of young females between 24 and 26 years old. Furthermore the study discuss and elaborate...

  14. Sublime Views and Beautiful Explanations

    DEFF Research Database (Denmark)

    Barry, Daved; Meisiek, Stefan; Hatch, Mary Jo

    To create a generative theory that provides beautiful explanations and sublime views requires both a crafts and an art approach to scientific theorizing. The search for generativity leads scholars to perform various theorizing moves between the confines of simple, yet eloquent beauty, and the...

  15. HIF-mediated innate immune responses: cell signaling and therapeutic implications

    Directory of Open Access Journals (Sweden)

    Harris AJ

    2014-05-01

    Full Text Available Alison J Harris, AA Roger Thompson, Moira KB Whyte, Sarah R Walmsley Academic Unit of Respiratory Medicine, Department of Infection and Immunity, University of Sheffield, Sheffield, UK Abstract: Leukocytes recruited to infected, damaged, or inflamed tissues during an immune response must adapt to oxygen levels much lower than those in the circulation. Hypoxia inducible factors (HIFs are key mediators of cellular responses to hypoxia and, as in other cell types, HIFs are critical for the upregulation of glycolysis, which enables innate immune cells to produce adenosine triphosphate anaerobically. An increasing body of evidence demonstrates that hypoxia also regulates many other innate immunological functions, including cell migration, apoptosis, phagocytosis of pathogens, antigen presentation and production of cytokines, chemokines, and angiogenic and antimicrobial factors. Many of these functions are mediated by HIFs, which are not only stabilized posttranslationally by hypoxia, but also transcriptionally upregulated by inflammatory signals. Here, we review the role of HIFs in the responses of innate immune cells to hypoxia, both in vitro and in vivo, with a particular focus on myeloid cells, on which the majority of studies have so far been carried out. Keywords: hypoxia, neutrophils, monocytes, macrophages

  16. Leptin inhibitors from fungal endophytes (LIFEs): Will be novel therapeutic drugs for obesity and its associated immune mediated diseases.

    Science.gov (United States)

    Chandra Mouli, K; Pragathi, D; Naga Jyothi, U; Shanmuga Kumar, V; Himalaya Naik, M; Balananda, P; Suman, B; Seshadri Reddy, V; Vijaya, T

    2016-07-01

    Treatment of obesity and its associated immune mediated diseases is challenging due to impaired function of leptin system. Thus leptin is providing an interesting target for therapeutic intervention. Leptin, an adipose tissue-derived adipokine, displays a variety of immune functions, and regulate both innate and adaptive immune responses. The increased secretion of leptin (hyperleptinemia) and production of proinflammatory cytokines has been implicated in the pathogenesis of obesity-related immune diseases such as diabetes mellitus, hypertension, atherosclerosis, cancer, systemic lupus erythematosus, rheumatoid arthritis, crohn's disease and multiple sclerosis. These disorders are managed through antibiotics and by cytokines replacement. However, the effectiveness of cytokines coupled to the complexity of the cytokine network leads to severe side-effects, which can still occur after careful preclinical evaluation. In addition, synthetic immunotherapeutics carries a degree of risk, is time-consuming and expensive. Hence, the complexity of existing therapy and adverse effects emphasizes the need of an alternative approach for the management of immune dysfunction associated with obesity and its related diseases. For the aforementioned diseases that are related to leptin overabundance, new drugs blocking leptin signaling need to be generated. The research on the discovery of clinically important novel compounds from natural source is expanding due to their safety and no side effect. The fungal endophytes are the microbes that colonize internal tissue of plants without causing negative effects to the host. They produce plethora of substances of potential use to modern medicinal and pharmaceutical industry. The increasing body of evidence associated with application of bioactive metabolites derived from fungal endophytes in diverse disease states merits its use as therapeutic drugs. In particular, the saponins have been extensively proved to modulate the immune system

  17. 面部皮脂腺囊肿美容治疗64例疗效观察%Observation on Therapeutic Effect of Homemade Beauty Curette Treatment on Facial sebaceous Cyst of 64 Cases

    Institute of Scientific and Technical Information of China (English)

    伦杰; 张亚楠; 吕心红

    2013-01-01

    目的: 探讨应用自制美容刮匙治疗面部皮脂腺囊肿的方法和疗效。方法应用与自制美容刮匙相同直径的针头穿破皮脂腺囊肿,将囊内物质部分自行溢出,然后应用自制美容刮匙刮除干净,用庆大霉素冲洗,用眼科有齿镊尽可能把囊壁部分或全部夹出,再使用庆大霉素冲洗,轻度加压包扎。结果门诊选择的64例患者,进行6个月的随访,无复发及影响面容的52例,占84%;复发、影响了面容的22例,占16%。结论此方法从美容角度,特别对年轻人,瘢痕体质者,女性进行面部皮脂腺囊肿的门诊美容治疗,不做刀口手术,达到美容目的,是理想、可行的治疗,但是较手术切除容易复发。%Objective Reach and applications of the methods and curative effect of homemade beauty curette treatment of facial sebaceous cyst. Method Use the same diameter needle homemade beauty curette to piercesebaceous cyst, overflow the capsule material by itself, and then clean it by using homemade beauty curette, use gentamicin to clean it, and then useophthalmic toothed forceps clamp cyst wall as far as possible, then use gentamicin to clean it and pack it softly. Result Sampled 64 patients and after 6 months follow-up, 84%of which, 52 of them, no recurrence and no bad influence for face;16%of which, 22 of them, recurrence and bad influence for the face. Conclusion From cosmetic point of view, this method is an ideal sebaceous cyst treatment especially for young people, physical scars and female. But easy to relapse compared with surgical resection.

  18. ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia.

    Science.gov (United States)

    Peirs, Sofie; Matthijssens, Filip; Goossens, Steven; Van de Walle, Inge; Ruggero, Katia; de Bock, Charles E; Degryse, Sandrine; Canté-Barrett, Kirsten; Briot, Delphine; Clappier, Emmanuelle; Lammens, Tim; De Moerloose, Barbara; Benoit, Yves; Poppe, Bruce; Meijerink, Jules P; Cools, Jan; Soulier, Jean; Rabbitts, Terence H; Taghon, Tom; Speleman, Frank; Van Vlierberghe, Pieter

    2014-12-11

    T-cell acute lymphoblastic leukemia (T-ALL) is a high-risk subtype of acute lymphoblastic leukemia (ALL) with gradually improved survival through introduction of intensified chemotherapy. However, therapy-resistant or refractory T-ALL remains a major clinical challenge. Here, we evaluated B-cell lymphoma (BCL)-2 inhibition by the BH3 mimetic ABT-199 as a new therapeutic strategy in human T-ALL. The T-ALL cell line LOUCY, which shows a transcriptional program related to immature T-ALL, exhibited high in vitro and in vivo sensitivity for ABT-199 in correspondence with high levels of BCL-2. In addition, ABT-199 showed synergistic therapeutic effects with different chemotherapeutic agents including doxorubicin, l-asparaginase, and dexamethasone. Furthermore, in vitro analysis of primary patient samples indicated that some immature, TLX3- or HOXA-positive primary T-ALLs are highly sensitive to BCL-2 inhibition, whereas TAL1 driven tumors mostly showed poor ABT-199 responses. Because BCL-2 shows high expression in early T-cell precursors and gradually decreases during normal T-cell differentiation, differences in ABT-199 sensitivity could partially be mediated by distinct stages of differentiation arrest between different molecular genetic subtypes of human T-ALL. In conclusion, our study highlights BCL-2 as an attractive molecular target in specific subtypes of human T-ALL that could be exploited by ABT-199. PMID:25301704

  19. BEAUTIFUL, SENSE OF BEAUTY AND ELEMENTS OF BEAUTY IN TURKISH “MÂNİ”

    Directory of Open Access Journals (Sweden)

    Bülent Kahraman Çolakoğlu

    2014-08-01

    Full Text Available This study underlines the “mâni” which represents anonymous folk literature reflecting Turkish cultural life. Turkish nation’s sense of beautiful and beauty, the elements of beauty which belong to beauty/beloved have been studied with reference to Turkish “mâni” in order to protect Turkish cultural treasures and ensure them to be inherited from generation to generation by functionalizing them. In the study, content analysis has been used in the process of data interpretation. 4068 “mâni”s which are in the source tagged with “Demir, Necati (2013, Türk Mânileri, Ankara: Gazi Kitabevi” have been examined and they have been analyzed and assessed in line with the predetermined purpose. With this study, it is consolidated that the Turks have always had advanced sense of beauty; they have always been a nation who has a taste for beauty and taste and sense of aesthetic since the old historical periods. It is observed that the poetic themes of hair, eyebrow, eyelash, eye, beauty spot, cheek-dimple, face, cheek-dewlap, waist, heel, skin, age, speech, smile, smell, jewellery/ornament, deportment, coquetry/manner/affection are used as elements of beauty in Turkish “mâni”.

  20. Is better beautiful or is beautiful better? Exploring the relationship between beauty and category structure.

    Science.gov (United States)

    Sanders, Megan; Davis, Tyler; Love, Bradley C

    2013-06-01

    We evaluate two competing accounts of the relationship between beauty and category structure. According to the similarity-based view, beauty arises from category structure such that central items are favored due to their increased fluency. In contrast, the theory-based view holds that people's theories of beauty shape their perceptions of categories. In the present study, subjects learned to categorize abstract paintings into meaningfully labeled categories and rated the paintings' beauty, value, and typicality. Inconsistent with the similarity-based view, beauty ratings were highly correlated across conditions despite differences in fluency and assigned category structure. Consistent with the theory-based view, beautiful paintings were treated as central members for categories expected to contain beautiful paintings (e.g., art museum pieces), but not in others (e.g., student show pieces). These results suggest that the beauty of complex, real-world stimuli is not determined by fluency within category structure but, instead, interacts with people's prior knowledge to structure categories. PMID:23242799

  1. Leptin-mediated ion channel regulation: PI3K pathways, physiological role, and therapeutic potential.

    Science.gov (United States)

    Gavello, Daniela; Carbone, Emilio; Carabelli, Valentina

    2016-07-01

    Leptin is produced by adipose tissue and identified as a "satiety signal," informing the brain when the body has consumed enough food. Specific areas of the hypothalamus express leptin receptors (LEPRs) and are the primary site of leptin action for body weight regulation. In response to leptin, appetite is suppressed and energy expenditure allowed. Beside this hypothalamic action, leptin targets other brain areas in addition to neuroendocrine cells. LEPRs are expressed also in the hippocampus, neocortex, cerebellum, substantia nigra, pancreatic β-cells, and chromaffin cells of the adrenal gland. It is intriguing how leptin is able to activate different ionic conductances, thus affecting excitability, synaptic plasticity and neurotransmitter release, depending on the target cell. Most of the intracellular pathways activated by leptin and directed to ion channels involve PI3K, which in turn phosphorylates different downstream substrates, although parallel pathways involve AMPK and MAPK. In this review we will describe the effects of leptin on BK, KATP, KV, CaV, TRPC, NMDAR and AMPAR channels and clarify the landscape of pathways involved. Given the ability of leptin to influence neuronal excitability and synaptic plasticity by modulating ion channels activity, we also provide a short overview of the growing potentiality of leptin as therapeutic agent for treating neurological disorders. PMID:27018500

  2. Fucose decorated solid-lipid nanocarriers mediate efficient delivery of methotrexate in breast cancer therapeutics.

    Science.gov (United States)

    Garg, Neeraj K; Singh, Bhupinder; Jain, Ashay; Nirbhavane, Pradip; Sharma, Rajeev; Tyagi, Rajeev K; Kushwah, Varun; Jain, Sanyog; Katare, Om Prakash

    2016-10-01

    The present study is designed to engineer fucose anchored methotrexate loaded solid lipid nanoparticles (SLNs) to target breast cancer. The developed nano-carriers were characterized with respect to particle size, PDI, zeta potential, drug loading and entrapment, in-vitro release etc. The characterized formulations were used to comparatively assess cellular uptake, cell-viability, apoptosis, lysosomal membrane permeability, bioavailability, biodistribution, changes in tumor volume and animal survival. The ex-vivo results showed greater cellular uptake and better cytotoxicity at lower IC50 of methotrexate in breast cancer cells. Further, we observed increased programmed cell death (apoptosis) with altered lysosomal membrane permeability and better rate of degradation of lysosomal membrane in-vitro. On the other hand, in-vivo evaluation showed maximum bioavailability and tumor targeting efficiency with minimum secondary drug distribution in various organs with formulated and anchored nano-carrier when compared with free drug. Moreover, sizeable reduction in tumor burden was estimated with fucose decorated SLNs as compared to that seen with free MTX and SLNs-MTX. Fucose decorated SLNs showed promising results to develop therapeutic interventions for breast cancer, and paved a way to explore this promising and novel nano-carrier which enables to address breast cancer. PMID:27268228

  3. Plant-Mediated Synthesis of Silver Nanoparticles: Their Characteristic Properties and Therapeutic Applications.

    Science.gov (United States)

    Chung, Ill-Min; Park, Inmyoung; Seung-Hyun, Kim; Thiruvengadam, Muthu; Rajakumar, Govindasamy

    2016-12-01

    Interest in "green nanotechnology" in nanoparticle biosynthesis is growing among researchers. Nanotechnologies, due to their physicochemical and biological properties, have applications in diverse fields, including drug delivery, sensors, optoelectronics, and magnetic devices. This review focuses on the green synthesis of silver nanoparticles (AgNPs) using plant sources. Green synthesis of nanoparticles is an eco-friendly approach, which should be further explored for the potential of different plants to synthesize nanoparticles. The sizes of AgNPs are in the range of 1 to 100 nm. Characterization of synthesized nanoparticles is accomplished through UV spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, transmission electron microscopy, and scanning electron microscopy. AgNPs have great potential to act as antimicrobial agents. The green synthesis of AgNPs can be efficiently applied for future engineering and medical concerns. Different types of cancers can be treated and/or controlled by phytonanotechnology. The present review provides a comprehensive survey of plant-mediated synthesis of AgNPs with specific focus on their applications, e.g., antimicrobial, antioxidant, and anticancer activities. PMID:26821160

  4. Plant-Mediated Synthesis of Silver Nanoparticles: Their Characteristic Properties and Therapeutic Applications

    Science.gov (United States)

    Chung, Ill-Min; Park, Inmyoung; Seung-Hyun, Kim; Thiruvengadam, Muthu; Rajakumar, Govindasamy

    2016-01-01

    Interest in "green nanotechnology" in nanoparticle biosynthesis is growing among researchers. Nanotechnologies, due to their physicochemical and biological properties, have applications in diverse fields, including drug delivery, sensors, optoelectronics, and magnetic devices. This review focuses on the green synthesis of silver nanoparticles (AgNPs) using plant sources. Green synthesis of nanoparticles is an eco-friendly approach, which should be further explored for the potential of different plants to synthesize nanoparticles. The sizes of AgNPs are in the range of 1 to 100 nm. Characterization of synthesized nanoparticles is accomplished through UV spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, transmission electron microscopy, and scanning electron microscopy. AgNPs have great potential to act as antimicrobial agents. The green synthesis of AgNPs can be efficiently applied for future engineering and medical concerns. Different types of cancers can be treated and/or controlled by phytonanotechnology. The present review provides a comprehensive survey of plant-mediated synthesis of AgNPs with specific focus on their applications, e.g., antimicrobial, antioxidant, and anticancer activities.

  5. Lipid raft-mediated Akt signaling as a therapeutic target in mantle cell lymphoma

    International Nuclear Information System (INIS)

    Recent evidence shows that lipid raft membrane domains modulate both cell survival and death. Here, we have found that the phosphatidylinositol-3-kinase (PI3K)/Akt signaling pathway is present in the lipid rafts of mantle cell lymphoma (MCL) cells, and this location seems to be critical for full activation and MCL cell survival. The antitumor lipids (ATLs) edelfosine and perifosine target rafts, and we found that ATLs exerted in vitro and in vivo antitumor activity against MCL cells by displacing Akt as well as key regulatory kinases p-PDK1 (phosphatidylinositol-dependent protein kinase 1), PI3K and mTOR (mammalian TOR) from lipid rafts. This raft reorganization led to Akt dephosphorylation, while proapoptotic Fas/CD95 death receptor was recruited into rafts. Raft integrity was critical for Ser473 Akt phosphorylation. ATL-induced apoptosis appeared to correlate with the basal Akt phosphorylation status in MCL cell lines and primary cultures, and could be potentiated by the PI3K inhibitor wortmannin, or inhibited by the Akt activator pervanadate. Classical Akt inhibitors induced apoptosis in MCL cells. Microenvironmental stimuli, such as CD40 ligation or stromal cell contact, did not prevent ATL-induced apoptosis in MCL cell lines and patient-derived cells. These results highlight the role of raft-mediated PI3K/Akt signaling in MCL cell survival and chemotherapy, thus becoming a new target for MCL treatment

  6. Symmetry and Beauty in Plato

    OpenAIRE

    Lloyd, David R.

    2010-01-01

    Plato writes about Beauty in many of his dialogues, particularly in the Symposium, but he has no word equivalent to our "Symmetry", and this concept was not then formalised. Nevertheless, there are indications that some aspects of the concept were understood, if only intuitively. Plato has a very abstract concept of beauty, and when he uses "beauty" to characterise the so-called "Platonic Solids" in the Timaeus, he seems to be emphasising at least their regularity. It can be argued that the w...

  7. Therapeutic targeting of myeloid-derived suppressor cells involves a novel mechanism mediated by clusterin.

    Science.gov (United States)

    Zhou, Junmin; Donatelli, Sarah S; Gilvary, Danielle L; Tejera, Melba M; Eksioglu, Erika A; Chen, Xianghong; Coppola, Domenico; Wei, Sheng; Djeu, Julie Y

    2016-01-01

    Myeloid-derived suppressor cells (MDSCs) constitute a key checkpoint that impedes tumor immunity against cancer. Chemotherapeutic intervention of MDSCs has gained ground as a strategy for cancer therapy but its mechanism remains obscure.We report here a unique mechanism by which monocytic (M)-MDSCs are spared, allowing them to polarize towards M1 macrophages for reactivation of immunity against breast cancer. We first demonstrated that curcumin, like docetaxel (DTX), can selectively target CD11b(+)Ly6G(+)Ly6C(low) granulocytic (G)-MDSCs, sparing CD11b(+)Ly6G(-)Ly6C(high) M-MDSCs, with reduced tumor burden in 4T1-Neu tumor-bearing mice. Curcumin treatment polarized surviving M-MDSCs toward CCR7(+) Dectin-1(-)M1 cells, accompanied by IFN-γ production and cytolytic function in T cells. Selective M-MDSC chemoresistence to curcumin and DTX was mediated by secretory/cytoplasmic clusterin (sCLU). sCLU functions by trapping Bax from mitochondrial translocation, preventing the apoptotic cascade. Importantly, sCLU was only found in M-MDSCs but not in G-MDSCs. Knockdown of sCLU in M-MDSCs and RAW264.7 macrophages was found to reverse their natural chemoresistance. Clinically, breast cancer patients possess sCLU expression only in mature CD68(+) macrophages but not in immature CD33(+) immunosuppressive myeloid cells infiltrating the tumors. We thus made the seminal discovery that sCLU expression in M-MDSCs accounts for positive immunomodulation by chemotherapeutic agents. PMID:27405665

  8. Therapeutic targeting of myeloid-derived suppressor cells involves a novel mechanism mediated by clusterin

    Science.gov (United States)

    Zhou, Junmin; Donatelli, Sarah S.; Gilvary, Danielle L.; Tejera, Melba M.; Eksioglu, Erika A.; Chen, Xianghong; Coppola, Domenico; Wei, Sheng; Djeu, Julie Y.

    2016-01-01

    Myeloid-derived suppressor cells (MDSCs) constitute a key checkpoint that impedes tumor immunity against cancer. Chemotherapeutic intervention of MDSCs has gained ground as a strategy for cancer therapy but its mechanism remains obscure.We report here a unique mechanism by which monocytic (M)-MDSCs are spared, allowing them to polarize towards M1 macrophages for reactivation of immunity against breast cancer. We first demonstrated that curcumin, like docetaxel (DTX), can selectively target CD11b+Ly6G+Ly6Clow granulocytic (G)-MDSCs, sparing CD11b+Ly6G−Ly6Chigh M-MDSCs, with reduced tumor burden in 4T1-Neu tumor-bearing mice. Curcumin treatment polarized surviving M-MDSCs toward CCR7+ Dectin-1−M1 cells, accompanied by IFN-γ production and cytolytic function in T cells. Selective M-MDSC chemoresistence to curcumin and DTX was mediated by secretory/cytoplasmic clusterin (sCLU). sCLU functions by trapping Bax from mitochondrial translocation, preventing the apoptotic cascade. Importantly, sCLU was only found in M-MDSCs but not in G-MDSCs. Knockdown of sCLU in M-MDSCs and RAW264.7 macrophages was found to reverse their natural chemoresistance. Clinically, breast cancer patients possess sCLU expression only in mature CD68+ macrophages but not in immature CD33+ immunosuppressive myeloid cells infiltrating the tumors. We thus made the seminal discovery that sCLU expression in M-MDSCs accounts for positive immunomodulation by chemotherapeutic agents. PMID:27405665

  9. Beauty Or Health? A Personal View

    OpenAIRE

    Riji, Haliza Mohd

    2006-01-01

    This paper deals with the question of beauty and health in women. It discusses changing definitions of beauty as a result of influences from the entertainment, beauty and health product industries. Advertisements are seen to be major players in defining beauty through promotion of cosmetic, skin, hair and slimming products. Concerns relating to beauty become inculcated in girls through the process of socialisation as they mature into womanhood. The media plays a significant role in portraying...

  10. Taxi Drivers and Beauty Contests

    OpenAIRE

    Camerer, Colin F

    1997-01-01

    The trading floor of the New York Stock Exchange. The British economist John Maynard Keynes likened playing the market to voting for the prettiest face in a beauty contest; hence the second part of this article’s title.

  11. Success: Talent, Intelligence or Beauty?

    OpenAIRE

    Gergaud, Olivier; GINSBURGH, Victor

    2010-01-01

    We analyze the Celebrity 100 annual list of the world’s most “powerful celebrities” compiled and published by Forbes Magazine. The lists provide an interesting collection of people, that includes their earnings, and the perception of citizens concerning the attributes that made them become celebrities. We analyze the relationship between their earnings and the perceptions on their intelligence, talent, beauty and other attributes, and show that though beauty plays a role, intelligence and tal...

  12. Beauty and Health: Anthropological Perspectives

    OpenAIRE

    Edmonds, Alexander

    2008-01-01

    This essay, written as a ‘teaser’ for an up-coming symposium, reflects on how human beauty can be understood from an anthropological and medical anthropological perspective. First, it considers how aesthetic and healing rationales can conflict or merge in a variety of medical technologies and health practices. Second, it discusses beauty in relation to the socioeconomic transformations of modernity and globalization. It suggests the need for a theoretical framework that departs from a strictl...

  13. THE BEAUTY AND THE SUBLIME

    OpenAIRE

    Bárbara Maria Brandão Guatimosim

    2008-01-01

    The text approaches the beauty and the sublime under the perspective of its intersections and of its function as barrier (the beauty), and as path to the reaching of desire (the sublime). From the kantian contribution to the notion of the Sublime along with the anxiety affect witch characterizes it, the concept of sublimation can be taken as a form of well saying, witch participates of a tragic-baroque esthetic, according with an impure desire ethic. Thereafter the text approaches the consequ...

  14. Role of LPS/CD14/TLR4-mediated inflammation in necrotizing enterocolitis: Pathogenesis and therapeutic implications

    Institute of Scientific and Technical Information of China (English)

    Kwong L Chan; Kwong F Wong; John M Luk

    2009-01-01

    AIM: To establish the roles of lipopolysaccharide (LPS)/CD14/toll-like receptor 4 (TLR4)-mediated inflammation in a rat model of human necrotizing enterocolitis (NEC). METHODS: Six pairs of intestinal samples from human NEC were collected before and after recovery for histological and molecular analysis of inflammatory cytokines and signaling components. In the rat NEC model, we isolated 10-cm jejunum segments and divided them into six groups ( n = 6) for sham operation, treatment with LPS, bowel distension, combined bowel distension and LPS stimulation, and two therapeutic groups. The potential efficacy of a recombinant CD18 peptide and a monoclonal CD14 antibody was evaluated in the latter two groups. The serum and tissue levels of several inflammatory mediators were quantified by real-time polymerase chain reaction, ELISA and immunoblotting. RESULTS: Human acute phase NEC tissues displayed significant increases ( P < 0.05) in levels of TLR4, CD14, myeloid differentiation protein (MD)-2, tumor necrosis factor (TNF)-α and nuclear factor-κB when compared to those after recovery. The histological and inflammatory picture of human NEC was reproduced in rats that were treated with combined bowel distension and LPS, but not in the sham-operated and other control rats. Serum levels of interleukin-6 and TNF-α were also elevated. The NEC pathology was attenuated by treating the NEC rats with a monoclonal CD14 antibody or an LPS-neutralizing peptide. CONCLUSION: LPS and distension are required to produce the histological and inflammatory features of NEC. A potential treatment option is blocking LPS activation and leukocyte infiltration.

  15. Beauty Or Health? A Personal View.

    Science.gov (United States)

    Riji, Haliza Mohd

    2006-01-01

    This paper deals with the question of beauty and health in women. It discusses changing definitions of beauty as a result of influences from the entertainment, beauty and health product industries. Advertisements are seen to be major players in defining beauty through promotion of cosmetic, skin, hair and slimming products. Concerns relating to beauty become inculcated in girls through the process of socialisation as they mature into womanhood. The media plays a significant role in portraying the meaning of beauty through its representation of women. These influences largely influence and alter women's perceptions of their body image and in trying to meet the goals of beauty as represented by the media. This may result in dissatisfaction with their body image. Advertisements can encourage women to indulge in smoking as a fashionable trend or opt for plastic surgery in attempts to acquire beauty. This paper concludes with implications of the issues relating to changing perceptions of beauty and suggests recommendations. PMID:26998213

  16. A trigger for beauty

    International Nuclear Information System (INIS)

    The possibility of B-meson experiments, in a fixed-target high-energy proton machine (Tevatron) is discussed. Compared to a B-meson factory experiment, it can produce 105, Banti B's per hour, using 108 protons per second, but it suffers from high background and needs high selectivity to cope with the million times higher interaction rate. To overcome these difficulties a technique called the 'optical trigger for beauty' is proposed, based on the detection of Cherenkov photons produced in a 2 mm thick LiF crystal, through a fast photodetector. Its virtue is that it is opaque to minimum-bias events originating in a small target, but sensitive to the high impact parameter B-meson decay charged particles from a secondary vertex. Calculations and first simulations results give a good efficiency for B-meson detection. A multistep trigger, combining the 'optical trigger' and a tracking detector, allows significant selection and a consequent enrichment of the data sample. Taking into account its fast response (∝ 1 ns), the above considerations can be extended to other hadronic machines, especially those with high-rate environments such as the LHC or SSC. (orig.)

  17. She Looks so Beautiful

    Directory of Open Access Journals (Sweden)

    Karen de Kock

    2008-07-01

    Full Text Available This article offers a story that illustrates how the medium of music is able to provide comfort, even in extreme cases of hopelessness, when all other efforts seem futile. I will relate how the creative act of music-making within an institutional setting, was able to provide comfort to a self-injurious female psychiatric client, who had been institutionalised all her life, to restore a sense of beauty and dignity which had been lost. The music that was created in the moment was also able to carry and support all the individuals who were creating it - even in the most desperate moments where those that were supposed to be "in command" were experiencing a sense of uncertainty. The story further demonstrates how a client, a care-worker and a therapist, three individuals from very diverse backgrounds and life circumstances, were able to transcend their different histories to come together and connect on a level which they have not been able to do outside the music therapy room.

  18. Cycles of Beauty Culture: Ethnography of Beauty Clinics Commodification

    Directory of Open Access Journals (Sweden)

    Sri Murlianti

    2014-12-01

    Full Text Available Skin care is not a completely new in beauty treatments. Previously there have been other types of cultural industry which also adopted the medical science, such as cosmetic and beauty salon industries. But, skin care beauty clinic successfully introduces the services of beauty treatments which are considered the healthiest. This paper is a summary of the research on how beauty clinic quickly became a part of everyday life of its consumers. The research focused on Natasha Skin Care, a most popular beauty clinic in Indonesia at the moment. According to Richard Johnson, the process of a culture industry reaches the society through a communication that in form a pattern cyclic communications. The stages in the pattern are interconnected but slipped, each stage is affecting others but are not specified in an uncertain manner; between the producer of culture industry with its consumers. This study is a multidiscipline research using three methods of interpretation namely ethnography, discourses analysis, and social hermeneutic study.Klinik kecantikan bukanlah budaya yang benar-benar baru dalam perawatan kecantikan. Sebelumnya telah ada jenis industri budaya lain yang juga mengadopsi ilmu kedokteran, seperti industri kosmetik dan salon kecantikan. Namun klinik kecantikan sukses menyandang predikat sebagai jasa perawatan kecantikan yang dianggap paling sehat. Tulisan ini merupakan rigkasan penelitian tentang bagaimana klinik kecantikan begitu cepat menjadi bagian hidup sehari–hari masyarakat konsumennya. Fokus penelitian ini adalah Natasha Skin Care, sebuah klinik kecantikan paling popular di Indonesia saat ini. Menurut Richard Johson proses sebuah industri budaya sampai pada masyarakat konsumennya melalui komunikasi yang timpang, membentuk pola komunikasi siklik, saling terhubung namun penuh dengan keterpelesetan, saling mewarnai namun tidak menentukan secara pasti antara produsen industri budaya dengan masyarakat konsumennya. Penelitian ini ditempuh

  19. Sleeping Beauties in Meme Diffusion

    CERN Document Server

    Zhang, Leihan; Xu, Ke

    2016-01-01

    A sleeping beauty in diffusion indicates that the information, can be ideas or innovations, will experience a hibernation before a sudden spike of popularity and it is widely found in citation history of scientific publications. However, in this study, we demonstrate that the sleeping beauty is an universal phenomenon in information diffusion and even more inspiring, there exist two consecutive sleeping beauties in the entire lifetime of propagation, suggesting that the information, including trending topics, search queries or Wikipedia views, which we call memes, will go unnoticed for a period and suddenly attracts some attention, and then it falls asleep again and later wakes up with another unexpected popularity peak. Further explorations on this phenomenon show that intervals between two wake ups follow an exponential distribution and the second awakening stage generally reaches its peak at a higher velocity and will bring a wider dissemination. Taking these findings into consideration, the upgraded Bass ...

  20. Two beautiful proofs of Pick's theorem

    OpenAIRE

    Raman Sundström, Manya; Öhman, Lars-Daniel

    2011-01-01

    We present two different proofs of Pick’s theorem and analyse in what ways might be perceived as beautiful by working mathematicians. In particular, we discuss two concepts, generality and specificity, that appear to contribute to beauty in different ways. We also discuss possible implications on insight into the nature of beauty in mathematics, and how the teaching of mathematics could be impacted, especially in countries in which discussions of beauty and aesthetics are notably absent from...

  1. Open Beauty Production at HERA

    OpenAIRE

    J. Kroseberg

    2001-01-01

    Recent results on open beauty production in positron-proton collisions at a centre-of-mass energy of 300 GeV are presented. The beauty photoproduction cross section is measured by ZEUS and H1 via the semileptonic decay. Both experiments use the transverse lepton momentum with respect to a jet as an observable. The H1 central silicon vertex detector makes it possible to analyse, in addition, the lepton impact parameter spectrum, thus exploiting lifetime information for the first time at HERA. ...

  2. All things bright and beautiful

    OpenAIRE

    Brown, Chloe

    2012-01-01

    'All Things Bright and Beautiful' was exhibited in 20/21 Visual Arts Centre, Scunthorpe, which is sited in a 'redundant' church. The fundamental question that the exhibition explored concerned the role of 'the animal' within contemporary art and within secular society, which in turn hoped to prompt reflections on our understanding of the place of 'the human' in the world and in nature. If there is no divine order, as posited by the hymn 'All Things Bright and Beautiful', where does this leave...

  3. Pluronic® L64-mediated stable HIF-1α expression in muscle for therapeutic angiogenesis in mouse hindlimb ischemia

    OpenAIRE

    Song, Hongmei; Liu, Sijia; Li, Caixia; Geng, Yanyan; Wang, Gang; Gu, Zhongwei

    2014-01-01

    Intramuscular injection of plasmid DNA (pDNA) to express a therapeutic protein is a promising method for the treatment of many diseases. However, the therapeutic applications are usually hindered by gene delivery efficiency and expression level. In this study, critical factors in a pDNA-based gene therapy system, such as gene delivery materials, a therapeutic gene, and its regulatory elements, were optimized to establish an integrated system for the treatment of mouse hindlimb ischemia. The r...

  4. Computers, pattern, chaos and beauty

    CERN Document Server

    Pickover, Clifford A

    1980-01-01

    Combining fractal theory with computer art, this book introduces a creative use of computers. It describes graphic methods for detecting patterns in complicated data and illustrates simple techniques for visualizing chaotic behavior. ""Beautiful."" - Martin Gardner, Scientific American. Over 275 illustrations, 29 in color.

  5. Quantum Beauty: Real and Ideal

    International Nuclear Information System (INIS)

    Does the world embody beautiful ideas? Pythagoras and Plato intuited that it should; Newton and Maxwell demonstrated how it could. But modern physics, and especially the quantum physics at its foundation, answers with a much more resounding and definitive 'Yes' I'll bring in history and art, as well as science, to make the case.(author)

  6. Beautiful Science: Worth a Visit

    Science.gov (United States)

    Bingham, Frederick M.

    2013-01-01

    For those in the profession of teaching physics who reside in or plan to visit the Los Angeles area, I would highly recommend a trip to the Huntington Library in San Marino, specifically to a permanent exhibit entitled "Beautiful Science: Ideas that Changed the World" in the Dibner Hall of the History of Science. The exhibit contains original…

  7. Beauty Products and the Consumer.

    Science.gov (United States)

    New York State Education Dept., Albany. Bureau of Secondary Curriculum Development.

    GRADES OR AGES: High school. SUBJECT MATTER: Consumer education especially as it concerns the consumer's desire for beauty. Included are considerations of cosmetics, health spas, reducing salons, wigs, and jewelry. ORGANIZATION AND PHYSICAL APPEARANCE: The guide is discursively organized through the topics listed above. The physical appearance of…

  8. Heart failure therapy mediated by the trophic activities of bone marrow mesenchymal stem cells: a noninvasive therapeutic regimen

    OpenAIRE

    Shabbir, Arsalan; Zisa, David; Suzuki, Gen; Lee, Techung

    2009-01-01

    Heart failure carries a poor prognosis with few treatment options. While myocardial stem cell therapeutic trials have traditionally relied on intracoronary infusion or intramyocardial injection routes, these cell delivery methods are invasive and can introduce harmful scar tissue, arrhythmia, calcification, or microinfarction in the heart. Given that patients with heart failure are at an increased surgical risk, the development of a noninvasive stem cell therapeutic approach is logistically a...

  9. Revealing the Beauty behind the Sleeping Beauty Problem

    OpenAIRE

    Mariolis, Ioannis

    2014-01-01

    A large number of essays address the Sleeping Beauty problem, which undermines the validity of Bayesian inference and Bas Van Fraassen's 'Reflection Principle'. In this study a straightforward analysis of the problem based on probability theory is presented. The key difference from previous works is that apart from the random experiment imposed by the problem's description, a different one is also considered, in order to negate the confusion on the involved conditional probabilities. The resu...

  10. Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells

    Directory of Open Access Journals (Sweden)

    Liz J. Valente

    2016-03-01

    Full Text Available Nutlin3a is a small-molecule antagonist of MDM2 that promotes non-genotoxic activation of p53 through p53 protein stabilization and transactivation of p53 target genes. Nutlin3a is the forerunner of a class of cancer therapeutics that have reached clinical trials. Using transgenic and gene-targeted mouse models lacking the critical p53 target genes, p21, Puma, and Noxa, we found that only loss of PUMA conferred profound protection against Nutlin3a-induced killing in both non-transformed lymphoid cells and Eμ-Myc lymphomas in vitro and in vivo. CRISPR/Cas9-mediated targeting of the PUMA gene rendered human hematopoietic cancer cell lines markedly resistant to Nutlin3a-induced cell death. These results demonstrate that PUMA-mediated apoptosis, but not p21-mediated cell-cycle arrest or senescence, is a critical determinant of the therapeutic response to non-genotoxic p53 activation by Nutlin3a. Importantly, in human cancer, PUMA expression may predict patient responses to treatment with MDM2 antagonists.

  11. Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells.

    Science.gov (United States)

    Valente, Liz J; Aubrey, Brandon J; Herold, Marco J; Kelly, Gemma L; Happo, Lina; Scott, Clare L; Newbold, Andrea; Johnstone, Ricky W; Huang, David C S; Vassilev, Lyubomir T; Strasser, Andreas

    2016-03-01

    Nutlin3a is a small-molecule antagonist of MDM2 that promotes non-genotoxic activation of p53 through p53 protein stabilization and transactivation of p53 target genes. Nutlin3a is the forerunner of a class of cancer therapeutics that have reached clinical trials. Using transgenic and gene-targeted mouse models lacking the critical p53 target genes, p21, Puma, and Noxa, we found that only loss of PUMA conferred profound protection against Nutlin3a-induced killing in both non-transformed lymphoid cells and Eμ-Myc lymphomas in vitro and in vivo. CRISPR/Cas9-mediated targeting of the PUMA gene rendered human hematopoietic cancer cell lines markedly resistant to Nutlin3a-induced cell death. These results demonstrate that PUMA-mediated apoptosis, but not p21-mediated cell-cycle arrest or senescence, is a critical determinant of the therapeutic response to non-genotoxic p53 activation by Nutlin3a. Importantly, in human cancer, PUMA expression may predict patient responses to treatment with MDM2 antagonists. PMID:26904937

  12. Is moral beauty different from facial beauty? Evidence from an fMRI study.

    Science.gov (United States)

    Wang, Tingting; Mo, Lei; Mo, Ce; Tan, Li Hai; Cant, Jonathan S; Zhong, Luojin; Cupchik, Gerald

    2015-06-01

    Is moral beauty different from facial beauty? Two functional magnetic resonance imaging experiments were performed to answer this question. Experiment 1 investigated the network of moral aesthetic judgments and facial aesthetic judgments. Participants performed aesthetic judgments and gender judgments on both faces and scenes containing moral acts. The conjunction analysis of the contrasts 'facial aesthetic judgment > facial gender judgment' and 'scene moral aesthetic judgment > scene gender judgment' identified the common involvement of the orbitofrontal cortex (OFC), inferior temporal gyrus and medial superior frontal gyrus, suggesting that both types of aesthetic judgments are based on the orchestration of perceptual, emotional and cognitive components. Experiment 2 examined the network of facial beauty and moral beauty during implicit perception. Participants performed a non-aesthetic judgment task on both faces (beautiful vs common) and scenes (containing morally beautiful vs neutral information). We observed that facial beauty (beautiful faces > common faces) involved both the cortical reward region OFC and the subcortical reward region putamen, whereas moral beauty (moral beauty scenes > moral neutral scenes) only involved the OFC. Moreover, compared with facial beauty, moral beauty spanned a larger-scale cortical network, indicating more advanced and complex cerebral representations characterizing moral beauty. PMID:25298010

  13. Facial beauty and fractal geometry

    OpenAIRE

    Schmidhuber, Juergen

    1998-01-01

    What is it that makes a face beautiful? Average faces obtained by photographic (Galton 1878) or digital (Langlois & Roggman 1990) blending are judged attractive but not optimally attractive (Alley & Cunningham 1991) --- digital exaggerations of deviations from average face blends can lead to higher attractiveness ratings (Perrett, May, & Yoshikawa 1994). My novel approach to face design does not involve blending at all. Instead, the image of a female face with high ratings is composed from a ...

  14. Baryons and Mesons with Beauty

    OpenAIRE

    Goldstein, Gary R.; Wali, Kameshwar C.

    2007-01-01

    Recent experimental findings of several mesons and baryons with "beauty" and "charm" as flavors remind us of the days when strangeness was discovered, and how its inclusion led to SU(3)-flavor symmetry with enormous success in the classification of the "proliferated" states into SU(3) multiplets. One of the key elements was the successful application of the first order perturbation in symmetry breaking, albeit what then appeared to be huge mass differences, and the prediction of new states th...

  15. Performing Beauty in Participatory Art and Culture

    DEFF Research Database (Denmark)

    Heinrich, Falk

    This book investigates the notion of beauty in participatory art, an interdisciplinary form that necessitates the audience’s agential participation and that is often seen in interactive art and technology-driven media installations. After considering established theories of beauty, for example......, Plato, Alison, Hume, Kant, Gadamer and Santayana through to McMahon and Sartwell, Heinrich argues that the experience of beauty in participatory art demands a revised notion of beauty; a conception that accounts for the performative and ludic turn within various art forms and which is, in a broader...... sense, a notion of beauty suited to a participatory and technology-saturated culture. Through case studies of participatory art, he provides an art-theoretical approach to the concept of performative beauty; an approach that is then applied to the wider context of media and design artefacts....

  16. The realization of absolute beauty: an interpretation of the fairytale Snow White.

    Science.gov (United States)

    Takenaka, Nanae

    2016-09-01

    This paper interprets the fairytale Snow White (Bruder Grimm 1857) in terms of the realization of absolute beauty. Jung's understanding that 'in myths and fairytales, as in dreams, the soul speaks about itself' (Jung 1945, para. 400), underpins such an approach. From this perspective a fantasy image is not about us, not about our unconsciousness, but is essentially about itself. The idea of absolute beauty first arises in the Queen's mind as a wish. Despite the Queen's strong desire to be named as the most beautiful person in the world, her mirror reflects that it is actually her daughter Snow White who is the fairest. Snow White might be regarded in the language of Giegerich as her internal other. Effectively they are separated into the Real that conceives the idea of absolute beauty and the Ideal that embodies it. The exchange that takes place between the two - mediated by mirror and window - generates the corpse of surpassing beauty that never decays but lies inaccessible behind the glass coffin. However the loving and penetrating gaze of the Prince, representing masculinity, succeeds in reanimating Snow White. Thus the Prince as the Other that is completely external and unknown to both the Queen and Snow White, specifically to their femininity, facilitates the realization of absolute beauty as the Ideal in the Real. PMID:27530170

  17. Ibrutinib interferes with the cell-mediated anti-tumor activities of therapeutic CD20 antibodies: implications for combination therapy

    DEFF Research Database (Denmark)

    Da Roit, F.; Engelberts, P. J.; Taylor, R. P.;

    2015-01-01

    The novel Bruton tyrosine kinase inhibitor ibrutinib and phosphatidyl-4-5-biphosphate 3-kinase-delta inhibitor idelalisib are promising drugs for the treatment of chronic lymphocytic leukemia and B-cell non-Hodgkin lymphoma, either alone or in combination with anti-CD20 antibodies. We investigated...... the possible positive or negative impact of these drugs on all known mechanisms of action of both type I and type II anti-CD20 antibodies. Pretreatment with ibrutinib for 1 hour did not increase direct cell death of cell lines or chronic lymphocytic leukemia samples mediated by anti-CD20 antibodies....... Pre-treatment with ibrutinib did not inhibit complement activation or complement-mediated lysis. In contrast, ibrutinib strongly inhibited all cell-mediated mechanisms induced by anti-CD20 antibodies rituximab, ofatumumab or obinutuzumab, either in purified systems or whole blood assays. Activation of...

  18. Beauty and critical art: is beauty at odds with critical–political engagement?

    Directory of Open Access Journals (Sweden)

    Maria-Alina Asavei

    2015-06-01

    Full Text Available Traditionally, beauty is understood as an ability of some objects (artworks included to occasion in viewers a distinctive type of unmediated/pure pleasure—aesthetic pleasure. According to this common understanding of beauty, political–critical art does not seem to raise in viewers the feeling of aesthetic pleasure. Many contemporary critical artists and politically engaged artists deliberately produce an art as unappealing to the senses as possible (their attitude could be called, following Arthur Danto, kalliphobia—“beauty phobia”. Critical art is a type of art which usually does not strike us with beauty at first sight because this “political art” usually deals with issues of social injustice and political struggles, rendering contemplation and aesthetic pure pleasure unachievable. Yet, even if beauty, in critical art's case, seems to be a difficult, demanding, and not an immediately recognisable one (mostly because of its unappealing, unsettling look, this does not mean that it lacks or is at odds with critical engagement (as some critical artists and theorists have argued. The argument of this paper is that not every beautiful thing looks good at first sight. By the same token, not everything that looks beautiful is in fact beautiful. Drawing on Immanuel Kant's neglected pulchritude adhaerens (dependent beauty, I argue that political–critical art is characterised by a dependent type of beauty (beauty a thing has as a thing of a certain kind and with a certain function as opposed to free beauty (as something we like it freely on its own account, independent of what it is and what it does. Political–critical art can claim a dependent beauty (an impure, “difficult” and not straightforward pleasurable type of beauty without being compelled to submit itself, at the same time, to the free beauty.

  19. Combined 2-deoxy glucose and metformin improves therapeutic efficacy of sodium-iodide symporter-mediated targeted radioiodine therapy in breast cancer cells.

    Science.gov (United States)

    Chatterjee, Sushmita; Thaker, Nirmal; De, Abhijit

    2015-01-01

    Radiosensitization using either metformin or 2-deoxy-d-glucose (2-DG) in various cancer cells has been reported. The present study reveals novel information on combining these drugs to enhance radiosensitization effect in breast cancer (BC) cells. Responses to low-dose Cobalt60 radiation, as well as a newly emerged radioiodine therapy target for BC, that is, sodium-iodide symporter (NIS or SLC5A5) protein, are tested. As therapeutic potential of NIS in BC is often limited due to low uptake and fast efflux rate of iodine, the scope of these two radiosensitizers to further improve NIS-mediated (131)I therapeutic efficacy is explored. Two BC cell lines, MCF-7, and MDA MB231 are tested to optimize minimal drug doses required for radiosensitization. A combination of 2 mM metformin and 20 mM 2-DG with 2 grey (Gy) Cobalt60 radiation shows significant radiosensitization effect (P=0.0002). In cells treated with the combination therapy, increased γH2A.X foci formation was noted. Further, MCF-7 BC cells overexpressing NIS (MCF-7 NIS) was established, and using the optimized drug concentrations, significant radiosensitization (P=0.0019) by 50 μ Ci (131)I usage was found to be the case as well. Apoptosis data corroborates with the result of clonogenic assay showing significant increase in apoptotic population upon dual drug-mediated radiosensitization. In case of metformin treatment, lowered adenosine triphosphate (ATP) content of the cell has been observed. The encouraging radiosensitization effect observed using combined 2-DG and metformin may aid in reducing Cobalt60 radiation exposure or for targeted radioiodine therapy in BC cells with NIS expression. This study indicates high potential of this drug combination in sensitizing BC cells for NIS-mediated-targeted radioiodine therapy, which otherwise may have lacked efficacy. PMID:26355636

  20. Perceiving beauty in all women: Psychometric evaluation of the Broad Conceptualization of Beauty Scale.

    Science.gov (United States)

    Tylka, Tracy L; Iannantuono, Amy C

    2016-06-01

    Women's ability to broadly conceptualize beauty (i.e., perceive many looks, appearances, body sizes/shapes, and inner characteristics as beautiful) has been identified as a facet of positive body image in qualitative research. A scale is needed to be able to assess this construct within quantitative research. Therefore, we developed the Broad Conceptualization of Beauty Scale (BCBS), which measures the extent women define female beauty widely within external and internal characteristics, and examined its psychometric properties among four community samples totaling 1086 women. Exploratory and confirmatory factor analyses revealed a unidimensional structure with nine items. The internal consistency, test-retest reliability, and construct (convergent, discriminant, and incremental) validity of its scores were upheld. Researchers and clinicians can use the BCBS alone to assess women's perceptions of female beauty, or they can use the BCBS alongside women's perceptions of self-beauty to more comprehensively explore women's ability to broadly conceptualize beauty for others and themselves. PMID:26971117

  1. Markkinointisuunnitelma RVB Beauty Clinic Kotka

    OpenAIRE

    Piipponen, Tiia

    2012-01-01

    Työn tarkoituksena oli tehdä markkinointisuunnitelma RVB Beauty Clinic Kotkalle. Tavoitteena oli selvittää yrityksen nykytilanne käytössä olevien tietolähteiden avulla ja luoda näiden perusteella selkeitä linjauksia yrityksen markkinointiin. Markkinointisuunnitelmaa lähdin luomaan asiakassuhdemarkkinoinnin näkökulmasta, koska kyseessä on yritys, jossa työskentelee vain yksi henkilö. Lähtötilanteen selvityksessä käytin yrittäjän ja maahantuojan haastatteluja, kilpailijoiden kotisivuja ja e...

  2. Beautiful Mirrors at the LHC

    OpenAIRE

    Kumar, Kunal; Shepherd, William; Tait, Tim M. P.; Vega-Morales, Roberto(Laboratoire de Physique Théorique, CNRS-UMR 8627, Université Paris-Sud 11, F-91405, Orsay Cedex, France)

    2010-01-01

    We explore the "Beautiful Mirrors" model, which aims to explain the measured value of $A^b_{FB}$, discrepant at the $2.9\\sigma$ level. This scenario introduces vector-like quarks which mix with the bottom, subtly affecting its coupling to the $Z$. The spectrum of the new particles consists of two bottom-like quarks and a charge -4/3 quark, all of which have electroweak interactions with the third generation. We explore the phenomenology and discovery reach for these new particles at the LHC, ...

  3. A Beautiful Proof by Induction

    OpenAIRE

    Öhman, Lars-Daniel

    2016-01-01

    The purpose of this note is to present an example of a proof by induction that in the opinion of the present author has great aesthetic value. The proof in question is Thomassen’s proof that planar graphs are 5-choosable. I give a self-contained presentation of this result and its proof, and a personal account of why I think this proof is beautiful. A secondary purpose is to more widely publicize this gem, and hopefully make it part of a standard set of examples for examining characteristics ...

  4. My Beautiful Relationship with China

    Institute of Scientific and Technical Information of China (English)

    Gian; Franco; Terenzi

    2014-01-01

    <正>The beautiful story of friendship began in 1987 when I served as Captain Regent(Head of State)of San Marino.Back then,I had some knowledge of China and decided to realize my dream of paying an offi cial visit there during my tenure.It was my first trip,so I did not know what was awaiting me.However,I was sure it would be something positive.At the head of a delegation,I arrived in China in February 1988.The reception was meticulous and incom-

  5. Free Harmonious Beauty of Greek Sculpture

    Institute of Scientific and Technical Information of China (English)

    郑晓杨

    2015-01-01

    Greek art in the content and form of the art of the beautiful, harmonious effect fully expresses the interpretation of the height of the spirit of freedom, and the Greek sculpture is a powerful representative of Greek art. In this paper, from a few large sculpture art to savor the Greek sculpture artistic freedom and harmonious beauty.

  6. ATTRACTION OF STUDENTS TOWARDS BEAUTY PRODUCTS

    Directory of Open Access Journals (Sweden)

    Fouzia Ali

    2011-07-01

    Full Text Available The purpose of this study was to measure the correlation and impact of deceptive beauty advertising (Ads with and on the buying behavior of the university students toward beauty products. Developed instrument contained nineteen questions. Five point Likert scale was used and the response rate was 94.667%. Two variables were computed; buying behavior of university students towards beauty products was dependent variable; and deceptive beauty ads were independent variable. Descriptive statistics, correlation and liner regression techniques were used with the help of SPSS 16. Positive and significant correlation and impact was found with and on the buying behavior of university students toward beauty products which means that the use of beauty products increases with the increase in deception in beauty products ads. The data were collected from university students and non-serious attitude of students were the limitations of this study. In this study, the main focus was on the buying behavior of students and beauty products ads, and it will serve as a benchmark for prospective researchers for future study.

  7. Beautiful Exit: Break Up With A Smile

    OpenAIRE

    Alajoutsijärvi, K; MÖller, K.; Tähtinen, J. (Jaana)

    1999-01-01

    This paper constructs a framework describing communication strategies available in dissolving interorganisational buyer-seller relationships. In particular, we bring in a quality aspect, as we are looking for strategies that could be labelled "beautiful exits". A beautiful exit is achieved by using a communication strategy that minimises damages occurring to the disengager, the other party and the connected network.

  8. Charm and beauty physics at Fermilab

    International Nuclear Information System (INIS)

    The status of charm and beauty physics studies at Fermilab is reviewed. Data from fixed target experiments on charm production, semi-leptonic decay, and Cabibbo suppressed decays as well as charmonium studies in antiproton annihilation are described. In addition beauty results from CDF and E653 are reviewed and prospects for studies of B physics at collider detectors are discussed

  9. Surrounded by Beauty: Arts of Native America.

    Science.gov (United States)

    2002

    Native American languages have no equivalent for the word "art." Yet the objects Native Americans have used and still use suggest that they are a highly spiritual people who create objects of extraordinary beauty. In Native American thought, there is no distinction between what is beautiful or functional, and what is sacred or secular. Design goes…

  10. Pluronic® L64-mediated stable HIF-1α expression in muscle for therapeutic angiogenesis in mouse hindlimb ischemia

    Science.gov (United States)

    Song, Hongmei; Liu, Sijia; Li, Caixia; Geng, Yanyan; Wang, Gang; Gu, Zhongwei

    2014-01-01

    Intramuscular injection of plasmid DNA (pDNA) to express a therapeutic protein is a promising method for the treatment of many diseases. However, the therapeutic applications are usually hindered by gene delivery efficiency and expression level. In this study, critical factors in a pDNA-based gene therapy system, such as gene delivery materials, a therapeutic gene, and its regulatory elements, were optimized to establish an integrated system for the treatment of mouse hindlimb ischemia. The results showed that Pluronic® L64 (L64) was an efficient and safe material for gene delivery into mouse skeletal muscle. It also showed intrinsic ability to promote in vivo angiogenesis in a concentration-dependent manner, which might be through the activation of nuclear factor kappa-light-chain-enhancer of activated B cell (NF-κB)-regulated angiogenic factors. The combination of 0.1% L64 with a hybrid gene promoter (pSC) increased the gene expression level, elongated the gene expression duration, and enhanced the number of transfected muscle fibers. In mice ischemic limbs, a gene medicine (pSC-HIF1αtri/L64) composed of L64 and pSC-based expression plasmid encoding hypoxia-inducible factor 1-alpha triple mutant (HIF-1αtri), improved the expression of stable HIF-1α, and in turn, the expression of multiple angiogenic factors. As a result, the ischemic limbs showed accelerated function recovery, reduced foot necrosis, faster blood reperfusion, and higher capillary density. These results indicated that the pSC-HIF1αtri/L64 combination presented a potential and convenient venue for the treatment of peripheral vascular diseases, especially critical limb ischemia. PMID:25092975

  11. Pluronic® L64-mediated stable HIF-1α expression in muscle for therapeutic angiogenesis in mouse hindlimb ischemia

    OpenAIRE

    Wang, Gang

    2014-01-01

    Hongmei Song,1 Sijia Liu,1 Caixia Li,1,2 Yanyan Geng,1,3 Gang Wang,1 Zhongwei Gu1 1National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, People’s Republic of China; 2Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, People’s Republic of China; 3Hebei University of Engineering, Handan, Hebei, People’s Republic of China Abstract: Intramuscular injection of plasmid DNA (pDNA) to express a therapeutic protein is a pro...

  12. Pluronic® L64-mediated stable HIF-1α expression in muscle for therapeutic angiogenesis in mouse hindlimb ischemia

    OpenAIRE

    Song H; Liu S; Li C.; Geng Y; Wang G; Gu Z

    2014-01-01

    Hongmei Song,1 Sijia Liu,1 Caixia Li,1,2 Yanyan Geng,1,3 Gang Wang,1 Zhongwei Gu1 1National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, People’s Republic of China; 2Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, People’s Republic of China; 3Hebei University of Engineering, Handan, Hebei, People’s Republic of China Abstract: Intramuscular injection of plasmid DNA (pDNA) to express a therapeutic protein is a promising metho...

  13. Antimicrobial peptides: mediators of innate immunity as templates for the development of novel anti-infective and immune therapeutics.

    Science.gov (United States)

    Hiemstra, P S; Fernie-King, B A; McMichael, J; Lachmann, P J; Sallenave, J-M

    2004-01-01

    Antimicrobial molecules are ancient and essential small cationic molecules of the host defence system which are found in a wide variety of species. They display antimicrobial activity against a wide range of bacteria, fungi and viruses, an activity that has been mostly attributed to the disruption of microbial membranes. In this article, we will review the "classical" functions of 3 classes of antimicrobial molecules, namely defensins, cathelicidins, and the four-disulfide core proteins secretory leukocyte proteinase inhibitor (SLPI) and elafin. In addition to the study of their expression in a variety of cell types and the regulation of their production, we will also describe novel properties of these molecules that have been highlighted by recent studies. These include their ability to chemoattract a variety of inflammatory, immune and other cell types (neutrophils, macrophages, monocytes, lymphocytes, mast cells, epithelial cells) in vitro and in vivo. In addition, we will discuss the potential use of these newly discovered properties for therapeutic or vaccination purposes, using protein- or gene-transfer based methodologies. Finally, we will examine in an extensive fashion the strategies used by microorganisms to circumvent and subvert host defence mechanisms, such as the modifications of cell membranes and walls, the secretion of inactivating proteins and proteases and the down-regulation of expression of antimicrobial molecules. Increased understanding of the mechanisms used by both the host and the microbes to 'win the battle' may ultimately lead to new therapeutic strategies aimed to treat infectious diseases. PMID:15379675

  14. The in vivo therapeutic efficacy of the oncolytic adenovirus Delta24-RGD is mediated by tumor-specific immunity.

    Directory of Open Access Journals (Sweden)

    Anne Kleijn

    Full Text Available The oncolytic adenovirus Delta24-RGD represents a new promising therapeutic agent for patients with a malignant glioma and is currently under investigation in clinical phase I/II trials. Earlier preclinical studies showed that Delta24-RGD is able to effectively lyse tumor cells, yielding promising results in various immune-deficient glioma models. However, the role of the immune response in oncolytic adenovirus therapy for glioma has never been explored. To this end, we assessed Delta24-RGD treatment in an immune-competent orthotopic mouse model for glioma and evaluated immune responses against tumor and virus. Delta24-RGD treatment led to long-term survival in 50% of mice and this effect was completely lost upon administration of the immunosuppressive agent dexamethasone. Delta24-RGD enhanced intra-tumoral infiltration of F4/80+ macrophages, CD4+ and CD8+ T-cells, and increased the local production of pro-inflammatory cytokines and chemokines. In treated mice, T cell responses were directed to the virus as well as to the tumor cells, which was reflected in the presence of protective immunological memory in mice that underwent tumor rechallenge. Together, these data provide evidence that the immune system plays a vital role in the therapeutic efficacy of oncolytic adenovirus therapy of glioma, and may provide angles to future improvements on Delta24-RGD therapy.

  15. Transcriptionally regulated and nontoxic delivery of the hyperactive Sleeping Beauty Transposase.

    Science.gov (United States)

    Cocchiarella, Fabienne; Latella, Maria Carmela; Basile, Valentina; Miselli, Francesca; Galla, Melanie; Imbriano, Carol; Recchia, Alessandra

    2016-01-01

    The Sleeping Beauty (SB) transposase and, in particular, its hyperactive variant SB100X raises increasing interest for gene therapy application, including genome modification and, more recently, induced pluripotent stem cells (iPS) reprogramming. The documented cytotoxicity of the transposase, when constitutively expressed by an integrating retroviral vector (iRV), has been circumvented by the transient delivery of SB100X using retroviral mRNA transfer. In this study, we developed an alternative, safe, and efficient transposase delivery system based on a tetracycline-ON regulated expression cassette and the rtTA2(S)-M2 transactivator gene transiently delivered by integration-defective lentiviral vectors (IDLVs). Compared with iRV-mediated delivery, expression of tetracycline-induced SB100X delivered by an IDLV results in more efficient integration of a GFP transposon and reduced toxicity. Tightly regulated expression and reactivation of the transposase was achieved in HeLa cells as wells as in human primary keratinocytes. Based on these properties, the regulated transposase-IDLV vectors may represent a valuable tool for genetic engineering and therapeutic gene transfer. PMID:27574698

  16. Pluronic® L64-mediated stable HIF-1α expression in muscle for therapeutic angiogenesis in mouse hindlimb ischemia

    Directory of Open Access Journals (Sweden)

    Song H

    2014-07-01

    Full Text Available Hongmei Song,1 Sijia Liu,1 Caixia Li,1,2 Yanyan Geng,1,3 Gang Wang,1 Zhongwei Gu1 1National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, People’s Republic of China; 2Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, People’s Republic of China; 3Hebei University of Engineering, Handan, Hebei, People’s Republic of China Abstract: Intramuscular injection of plasmid DNA (pDNA to express a therapeutic protein is a promising method for the treatment of many diseases. However, the therapeutic applications are usually hindered by gene delivery efficiency and expression level. In this study, critical factors in a pDNA-based gene therapy system, such as gene delivery materials, a therapeutic gene, and its regulatory elements, were optimized to establish an integrated system for the treatment of mouse hindlimb ischemia. The results showed that Pluronic® L64 (L64 was an efficient and safe material for gene delivery into mouse skeletal muscle. It also showed intrinsic ability to promote in vivo angiogenesis in a concentration-dependent manner, which might be through the activation of nuclear factor kappa-light-chain-enhancer of activated B cell (NF-κB-regulated angiogenic factors. The combination of 0.1% L64 with a hybrid gene promoter (pSC increased the gene expression level, elongated the gene expression duration, and enhanced the number of transfected muscle fibers. In mice ischemic limbs, a gene medicine (pSC-HIF1αtri/L64 composed of L64 and pSC-based expression plasmid encoding hypoxia-inducible factor 1-alpha triple mutant (HIF-1αtri, improved the expression of stable HIF-1α, and in turn, the expression of multiple angiogenic factors. As a result, the ischemic limbs showed accelerated function recovery, reduced foot necrosis, faster blood reperfusion, and higher capillary density. These results indicated that the pSC-HIF1αtri/L64 combination presented a potential and convenient venue for

  17. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Paris; Sun

    2011-01-01

    <正>01Aesop来自澳洲的"伊索寓言">"伊索寓言"在巴黎上演,Aesop巴黎店最新橱窗展,伊索灵魂漫游于方寸橱窗间。成立于1987年的澳洲品牌伊索(Aesop),在纯天然植物护肤的基础上率先推行有机理念,并结合内外调理的"理智"生活哲学。出身于拥有最多濒临绝种的奇花异草、珍禽怪兽的澳大利亚净土,品牌从研发、测试到

  18. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie; Kwok

    2011-01-01

    <正>01抗敏医美学>据说橄榄树非常长寿,可以健康地存活1000年,所以科学家相信橄榄树含有保持青春的成分,知名的皮肤科医生及抗衰老专家Nicholas Perricone博士研发的Perricone MD护肤品牌,就是以橄榄叶及其果实的天然分子橄榄多酚为敏感肌肤带来有效护理的抗衰老系列。

  19. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Jasmine; Chris

    2009-01-01

    <正>01寻找秋冬发型灵感>Aveda刚发表了新一季发型及发色潮流造型照,品牌的环球创作总监Antoinette Beenders介绍这系列灵感启发自80年代的歌德式华丽,他说:"今季的造型设计大量运用了复古味极浓的经典剪裁和发色。"一如以往,Aveda的造型设计无论是发型及发色都相当实用,参考价值甚高,想改变造型又没有头绪的话,可到品牌的网址找找合心意的发色与发型,更有来自世界各地的造型师所提供的理发建议。除此之外,可留意这辑造型照的另一个特别之处:模特儿所穿的礼服,全采用可循环再用的物料制造,如旧报纸、旧牛仔布料及风衣等,重新解构再造,非常合乎Aveda的环保原则。

  20. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Chris

    2010-01-01

    <正>01Christian Dior贵族淑女踏春归来随着马蹄声的配乐响起,Christian Dior宣布贵族淑女的时代回归。绣花、珍珠、花朵这些春意盎然的细节都运用到了薄纱以及各种轻盈的材质上。马鞭与马靴还有骑马的高帽搭配着长裙,优雅帅气的骑士装扮瞬间抓住了在场女士们的心。在妆容上,化妆师

  1. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Kidd Ji

    2010-01-01

    <正>01逆转光老化>光老化是目前被认为肌肤衰老的最大元凶。有害的紫外线深入肌肤深处,直接伤害细胞DNA,破坏肌肤自我更新过程,同时引发自由基,对肌肤造成进一步的间接伤害。在美国,激光被运用在光老化引起的皱纹、松弛的肌肤治疗上,因为术后红肿的反应并不多,所以很多人都能接受。但你需要为之付出疼痛感和一到两万元的高额费用。随着美容产品技术的提高与开发,基于医学美容的CLINIQUE

  2. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    2014-01-01

    <正>眼部的流线美学2014秋冬的T台妆容,醒目又流畅的眼妆深入人心,能够一根根修饰睫毛的睫毛刷,触感光滑柔软的丝绒效果眼影,勾勒夸张猫眼效果的厚泽眼线,所有的产品都重在打造自然流畅中可扩大眼形的清秀眼妆。01细致巧妙地提亮肌肤疲惫黯淡区域圣罗兰明彩笔1#2.5ml/RMB36002柔滑质感与千变万化的妆效圣罗兰臻彩四色眼影5#5g/RMB56003惊艳系列,打造含情脉脉的眼神迪奥单色眼影3g/RMB31004打造诱惑双眸的波普粉色迪奥魅惑睫毛膏9ml/RMB36005精致珍珠母贝令双眸晶莹闪亮希恩黎植物炫彩眼影06极其柔软,幼滑的眼线笔希思黎植物丝缎眼线笔

  3. Beauty

    Institute of Scientific and Technical Information of China (English)

    Katie Kwok

    2012-01-01

    <正>01澳大利亚有机美发>澳大利亚天然资源丰富,所以不少美容品牌都从当地的有机农庄获取原材料,主要因为有机草本成分内含的维他命、矿物质等营养成分比非有机草本植物高,同时有助减少吸收不必要的抗生素、农药等化学成分,令消费者更安心使用。澳洲进口品牌australian organics,在澳洲拥有十五年历史,产品包括面部护理、沐浴及身体护理以及头发护理系列。其有机成分获澳洲国家可持续农业协会机构(NASAA)认可,并属澳洲低碳产品商认可成员,全部产品均于澳洲制造,绝对不含石化成分、人造香料、色素及任何基因改造和动物测试,成分温和,容易吸收,特别适合亚洲人肌肤。品牌根据不同发质及肌肤需要,以天然草本成分调配不同配方外,亦以舒缓、减压、安抚情绪、助眠等有机香熏精华调配而成,让秀发及头部皮肤获得细致呵护之余,于感官上也同时得到洗涤,令日常护理程序变得更轻松。

  4. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Chris

    2010-01-01

    <正>01DNA科技注入睫毛膏>在护肤品中添加生物基因技术,已不再是什么大新闻。但你听说过,在睫毛膏里也加入这一科技吗?7月即将问市的Lancome全新梦魅臻采睫毛膏,就以兰蔻高科技研究成果为基础,加入了独一无二的基因配比技术,用以启动睫毛干细胞的活性,促进干细胞新生,仿佛为睫毛注入第二次生命般,让睫毛变长变密。同时,特别研制的刷头,可以更好的让膏体和睫毛接触,达到更完美的浓睫艳眸效果。www.lancome.com

  5. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Jasmine; Chris

    2010-01-01

    <正>022010 Chanel春夏高级成衣发布会后台彩妆探秘在这场仿佛是法国皇后Marie Antoinette在凡尔赛宫的小农庄重现的时装秀上,除了精致奢华的新款时装令人眼前一亮之外,彩妆创意总监Peter Phillips在妆容上也为我们带来了新一年的流行趋势,那就是以高雅别致的米色调为主,打造令人耳目一新、清新富有朝气的妆容。这种邻家女孩味十足的妆容效果,基本适合所有的女性,所有的场合。如果你嫌妆容过于"平淡",那

  6. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Kidd Ji

    2010-01-01

    <正>01悦木之源"眼咖啡">一直以为,累了、困了只要一杯咖啡就能提神解乏。却没想到,咖啡的活力还能喂进眼睛里,仿佛永远没有睡醒的倦怠双眼,在遇见悦木之源人参活力焕亮眼霜之后便能苏醒。这款在业界素有"精神眼霜"、"眼咖啡"、"加班眼霜"等众多俏皮昵称的Origins GinzingTM人参活力焕亮眼霜优选两款醒神植物能量——"百草之王"人参与"醒神之王"咖啡,同时融汇了冬虫夏草、木兰花、锦紫苏、橙皮苷、黄芩、绿茶等多种活力秘方,能够有效针对改善黑眼圈、眼部浮肿和眼疲劳等眼部问题,仿佛给倦眼来一杯Espresso。

  7. Beauty

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

    <正>眉:自然生态眉首先要扭转精致、服帖、细长才是完美眉形的观念。选择比发色淡一度的眉粉自下眉头处1cm处为起点,向眉峰轻扫,进而顺延至眉尾,别忘记用余粉将眉毛边缘处做好过渡。最后用眉形修饰膏以先顺再逆的方向梳理眉毛,缔造根根分明的印象。眼:亚洲人的内陷式双眼皮,令彩色眼线往往不足以提升眼晴的精气神。双色眼线以深色在靠近内眼睑的位置铺底,此处精细和轻巧的眼尾上挑是关键,然后用明媚的彩色眼线以略宽出1~2cm的方式勾勒,霎时拥有明眸点睛的魅惑力。

  8. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    <正> 今年起,说到最有效的抗氧化成分,你脑中该留下一个新名词"IDEBENONE 艾地苯"。这种由 ELIZABETH ARDEN 携手 BOTOX 肉毒杆菌素的创造者——ALLERGAN 联手推出的新成分已被运用在"PREVAGE 逆时橘灿精纯凝露"中,掀起了全球医学美容热潮。被称为"抗氧化超人"的它在18岁后即可每天使用,对抗光老化及预防皱纹。

  9. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Chris

    2010-01-01

    <正>01至真"纸"美>美国时装真人秀节目《Project Runway》在最近的一期节目里,请参赛者们用牛皮纸来代替寻常的布料,做出属于自己的牛皮纸时装,结果平时表现平平的参赛者都发挥得不错。原因何在?牛皮纸那朴实无华,却坚韧有型的特色赋予了"材料"更多的可塑性,同时也呼应了当下全球大热的

  10. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie; Kwok

    2011-01-01

    <正>01Burberry Body全新香氛>Burberry Body找来英国女演员兼模特儿Rosie Huntington-Whiteley,让她成为品牌的第一位代言人,从她身上完美地体现出感性、自信和谦逊的平衡。全新香氛使用的成分亦不简单,除了以天然玫瑰精油和香草为基调外,前调的苦艾酒曾一度是欧洲禁酒,也是梵高每次画画必喝的最爱。品牌还在香水瓶上花了不少心思,品牌刨作总监Christopher Bailey表示:"我常将

  11. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie; Kwok

    2011-01-01

    <正>01植村秀东京眼妆美学〉植村秀这彩妆品牌相信是不少潮流达人的心头好,不只因为其一流品质,更因为品牌从来以"不停构思改进与发掘"为哲学,不断推陈出新。今季炎夏,配合自由配搭彩妆盒,及全新系列眼影色系,品牌打造个人独特的彩妆盒。彩妆盒由日本著名建筑师干久美子设计,简洁优雅之余,亦令彩妆盒不需使用任何黏贴工具,亦能轻松替换眼影及胭脂组合。

  12. Beauty

    Institute of Scientific and Technical Information of China (English)

    Jasmine; Chris

    2010-01-01

    <正>03Jean Paul Gaultier 2010春夏高级订制:梦游"奇幻乐园"〉老顽童Jean Paul Gaultier这次给彩妆大师Tom Pecheux出了一个趣味横生的妆容课题—fantasy land。于是Tom Pecheux把墨西哥人、外星人、甚至是热映的电影《Avatar》都搬上了T台。模特们的妆容被大自然的缤纷色彩所填满,限部以天空蓝、植物绿、夕阳橙和大地黄为

  13. Beauty

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    一年之中,可以好好重整肌肤状况的有两个时段,分别是3,4月和10,11月,这两个时节,肌肤刚从剧烈的换季变化中回复平稳,最适合趁机除去累积的废物,并补充肌肤所需的营养,就像大病之后需要恢复元气一样。

  14. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie; Kwok

    2011-01-01

    <正>01有机"炼金术">古时人们相信可以从金属中提炼长生不老的丹药,虽然现代科学已证实炼金术不能提炼所谓"仙丹",但却令人类对物质和化学有了进一步的认识和了解。因为这些知识,让我们可以从自然环境中萃取各种天然成分,合成及研发成各种不只对皮肤或身体有益的产品,更有效地减少了浪费和不必要的消耗。

  15. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie Kwok

    2012-01-01

    <正>01好莱坞巨星的活肤秘诀>由匈牙利皮肤科医生Dr.Laszlo创办的纽约品牌Emo Laszlo,一直深受皇室名人及好莱坞巨星的喜爱,今年是Emo Laszlo创立八十五周年,特别以五位家喻户晓的好莱坞女星为灵感,推出八十五周年限量版好莱坞尊贵系列。五款尊贵系列的原装产品分别为珍珠亮采唤肤啫喱、魅惑水润修护眼霜、Refresh尊贵宝石再生补湿霜、搪瓷肌抗氧化修护霜及丝滑

  16. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Kidd; Ji; Paris; Sun

    2011-01-01

    <正>01一片蓝心向北非Giorgio Armani用一种颜色完成了2011春夏女装秀,撒哈拉沙漠中部游牧民族图阿雷格人的文化就是其女装的灵感来源。而品牌彩妆的特质在于其质感和色彩都基于时装的灵感、布料的材质之上。2011年春夏妆容,其灵感同样延续来自图阿雷格人面纱的颜色——靛蓝。设计师Giorgio Armani认为:"蓝与黑的搭配会让经典的黑色更有生命力。"通过对蓝色和黑色搭配的重新诠释,赋予了品牌招牌式优雅更富故事性与情境感的篇章。

  17. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie; Kwok

    2011-01-01

    <正>01台湾有机>说起护肤品的出产地,瑞士美国等欧美传统美容王国当然占市场大部分位置,但有时候因气候水土不同,在美国用起来一流的产品,来到亚洲可能就要大打折扣。近年除了韩国,台湾出产的美容护肤产品亦大受欢迎,除了一流的质量外,价位亦十分相宜。以统欣生物科技公司旗下品牌之一Deary媞尔妮为例,在身体及脸部保养品领域开发专研,以有机草本原料,配合独特研发技术,其面膜销售更是台湾连锁便利店排行第一。统欣生物科技公司,除了研发有效的护肤品之余,亦对护

  18. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie Kwok

    2012-01-01

    <正>01救生员认可的有机防晒美国生态环境研究专家Chris Birchby的家人,不幸患上黑色素瘤,令他明白防晒的重要,同时作为生态环境研究专家,他亦希望护肤品不会加重地球的负担,所以研发出防晒品牌COOLA,以有机天然成分为主,同时以物理性及化学性的防晒配方,推出高效的防晒产品,除了获得各个有机认证外,亦获得美国救生员协会的认可。

  19. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie Kwok

    2012-01-01

    <正>01摩诃之美>摩诃本为梵文,在佛教中有超越有情与无情,在无边无际、有形与无形之间显得圆通神妙用的意思。正如Cle de PeauBeaute秋冬妆容系列,以光亮色彩从黑暗中反映出来,以阴影映衬着明亮的双眸,以光泽衬托出不一样的色彩。品牌的彩妆美容形象师Lucia Pieroni说:"色彩在黑暗中绽亮生辉,令眼影细滑如丝。炯炯有神的明眸,在色彩与质感交织下美丽迷人,映照神秘的黑夜。"而系列最新三款让人惊艳的眼影色调,以散发不同光芒的珠光组合塑造聚光焦点,色彩中若隐若现的光泽,在瞳孔中映照出神秘光芒,演绎高贵优雅的魅力。色调可随意混配,

  20. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie Kwok

    2012-01-01

    <正>01意大利大家闺秀>Valentino除了经典的火红女郎形象外,近年时装秀的蕾丝都充分表现出品牌对女性妩媚的诠释。而今次Valentino的首支吞氛更是为其女性时装及生活方式所启发。为了这支香氛像是一束综合了多种鲜花精炼而成的香味,选用的材料都极度女性化,充分代表了Valentino女性的独特气质,因此便以Valentina命名。品牌邀两位杰出的调香师:Oliver Cresp

  1. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Kidd Ji

    2010-01-01

    <正>01Chanel 2010 Couture Makeup在高级订制服的秀场上,时装及配饰不但影响着未来一至两季的服装潮流,模特的妆容作为整个系列的点睛之笔,也对妆容的流行指明方向。由Chanel全球彩妆创意总监Peter Philips为秋冬高级订制系列创作的红色概念妆容就是其中一个例子。Peter Philips表示,他的设计概念来自Karl Lagerfeld向他展示的设计草图:"我发现他在所有的模特嘴上都加上了一抹红色。而他展示给我看的第一件外套也是红色

  2. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Kidd; Ji; Paris; Sun

    2011-01-01

    <正>01纸艺幻发纸艺能成为备受关注的艺术形态,是因为纸本身拥有轻盈及可塑性强的特质,再配合极富想象力的创作,即能呈现出千变万化的视觉形象,承载无限艺术价值。沙宣认为头发与纸艺的创作概念如出一辙,今年冬季亦从纸艺中汲取灵感,设计出了轻盈、可塑的概念发型。以"逆重幻觉"为名的发型特辑借用纸艺"挣脱重力的束缚仿佛能够对抗万有引力的存在"这一概念,丰盈的发型在充满空气感的同时,造型上也十分具有纸张所带来的结构感。当被问及如何打造这样的发型时,其创意总监回答:"关键在于拥有轻盈可塑的健康秀发。"道理虽不难,达到却不易。

  3. Beauty

    Institute of Scientific and Technical Information of China (English)

    Jasmine; Chris

    2010-01-01

    <正>01沪上定制妆容〉香奈儿巴黎——上海高级手工坊将时尚大帝Karl Lagerfeld和彩妆大师Peter Philips都带来了上海,除了为上海度身定做的华服之外,那颇有东方韵味的妆容也令人印象深刻。Peter在采访中透露这次妆面的灵感来自Karl给他看的一部电影——《花样年华》。模特们的妆容需要看上去既要有像张曼玉穿旗袍时的优雅,又能表现出如未来女战士般的魄力。正如服装秀一开场,模特们所穿着服装的灵

  4. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie Kwok

    2012-01-01

    <正>01蜗牛美容秘辛〉早于1980年,智利皮肤科医生Mr.Fernando Bascunan就已发现蜗牛分泌物具有非凡的护肤功效。当时他的家族以养殖蜗牛为生,并出口至欧洲各国成为美食。多年来在处理蜗牛的过程中,Fernando Bascunan意外地发现,工人被工具刮伤的患处不但没有发炎伤口愈合会更快,也不会留下疤痕。自此以后,他就开始对蜗牛进行研究,发现蜗牛黏液可在人类皮肤上产生嫩肤、再生及修复的神奇功效。近年来不少美容品牌都开始投放资源,研发蜗牛黏液护肤品,其中来自韩国的MISSHA,以韩国锦

  5. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie; Kwok

    2011-01-01

    <正>01从不泛黄的照片谈美白>现在什么都谈数码化,数码相机的科技水平也越来越高,但是十分值得纪念的相片,还是会有冲印出来的冲动。富士牌的相机胶卷你一定听过用过吧,用它冲印出来的相片,不论经过多少年,相片上的颜色不只没有泛黄,更没有褪色。原来,照相的相机胶卷是用骨胶原制成的。相同道理,如果富士能将相机胶卷用的骨胶原保持最佳状态,它们亦会知道怎样保护我们皮肤的骨胶原。所以当富士推出Fijifilm beauty系列,对女士们来说,可谓福音!

  6. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Paris; Sun

    2011-01-01

    <正>01美妆拜占庭拜占庭艺术(Byzantine art)指东罗马帝国的艺术。大体来说,所有拜占庭的艺术都充满了精神的象征主义。重视心象,不容有写实主义的存在。为配合Chanel巴黎一拜占庭高级手工坊系列成衣发布,Chanel全球彩妆创意总监彼德·菲利浦斯以世界知名的狄奥多拉女皇Theodora的马赛克肖像图为灵感创作了一组妆容,而肖像图中女皇眉峰部分所描绘的红色眼影线条,被他用作了这次妆

  7. Beauty

    Institute of Scientific and Technical Information of China (English)

    James; Stephen; Behrens; 王海强

    2006-01-01

    古往今来,人们一直通过语言、艺术或思考来探究人生的真谛。有人以追求人生的真理为乐,甚至是舍生取义;也有人在追求真理的过程中不断完善自己的生命。本文以朴实的文笔娓娓述说了一个令人深思而嗟叹的故事。故事女主人公相貌丑陋,但却以她独特的灵气、细腻的美感、动人的话语征服了人心。她对待人生的态度和生活的勇气,无疑会令所有的身体健康者汗颜!

  8. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie Kwok

    2012-01-01

    <正>01世界海洋大同>La Mer的世界海洋日活动,不仅要提升大家对海洋美态和修复力量的关注,更要呼吁人们对它脆弱的生态多加爱惜。La Mer相信海洋植物如太平洋海藻,其惊人力量尚未被完全发掘及理解,所以我们应全力支持生态保育,为下一代守护并保存这大自然的瑰宝。今年的世界海洋日活动鼓励大众探索、发掘和欣赏海洋宝库。La Mer特别设计了一百毫升的世界海洋日Creme de la Mer限量版面霜,瓶身设计的灵感亦撷取

  9. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie; Kwok

    2011-01-01

    <正>01闪耀细胞思维论〉Cle de Peau Beaute认为每一个皮肤细胞,犹如脑细胞一样,能够自我思考。它们均具有处理各种情报的能力,只要有效管理细胞使之接收更多正面讯息,阻截负面情报,提升肌肤本身的机制优化细胞机能,便能诱导更多正面讯息能量的吸收,从而改善皮肤质量。而全新Basic Care系列,便是因应闪耀细胞管理而研发。

  10. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Chris

    2010-01-01

    <正>01帝王之水典藏版华丽开售>现在你不必亲身飞到巴黎或香港等地,Guerlain巴黎之家专属限量香氛上海梅龙镇伊势丹精品专柜店将在7月隆重揭幕。作为国内唯一一家精品店,也是香榭丽舍大道68号LaMaison Guerlain娇兰之家的华丽缩影,在此你可以独家购买到帝王之水金箔蜂姿琉金典藏版等多款限量版香水。帝王之水乃品牌创始人Pierre Francois Pascal为法国Eugenie皇后特别制作的新婚礼物,清新、芬芳而怡神的它,是橙花、香橼、柠檬、

  11. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Kidd Ji

    2010-01-01

    <正>01Rene Gruau与美妆传承法国画家Rene Gruau的重要,不仅来自他独特的虚实结合水彩风格,将东西方绘画艺术相结合,令20世纪中期的人们耳目一新。他与Dior品牌合作,让插画与Dior在50年代推出的"New Look"风格紧密结合,流畅大气的线条勾勒出明显的女性曲线,修身、高雅、大气,这些插画与人们脑中的Dior服饰产生了不可分割的联系。2010年11月10日至2011年1月9日,名为"Dior插画展:Rene Gruau与美妆传承"的展览将于伦敦萨默塞特宫隆重举行。这场展览将向公众展现里程碑式的艺术珍品,荟集了经严格甄选的Dior高级定制礼服,以及Gruau特别为Dior香水化妆品品牌、古董香水瓶、时装手绘稿和杂志精心绘就的原创插画。六位英国出生的插画家亦将应邀在此次展览中展示画作,Gruau与Dior迪奥品牌的无间合作正是他们的灵感源泉。

  12. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie Kwok

    2012-01-01

    <正>01皇室御用彩妆盒〉Cle de peau Beaute邀得皇室御用珠宝设计师Shaun Leane,为春夏特别推出的Luminizing Face Enhancer设计一个闪烁夺目的盒子。Shaun Leane曾任皇室御用珠宝师及Alexander McQueen的首席珠宝设计师。他是英国FlPG获奖者,该奖项专门表扬技术超凡的珠宝匠师。精美闪烁的宝石切割面粉盒,一丝不苟的设计,令彩妆盒精致如珠宝盒一样,带有高贵优雅气派。Shaun Leane指出:"最初构思包装设计时,第一个念头是塑造既富触感又美观的盒子。在美感方面,我们希望设计宛如一件多琢面的

  13. Bathing in Reeking Wounds: The Liberal Arts, Beauty, and War

    Science.gov (United States)

    Stimpson, Catharine R.

    2014-01-01

    A historic dialectic exists between the beautiful and the bestial. The bestial destroys the beautiful, but in a bloody miracle, the beautiful emerges from the womb of the bestial, the "terrible beauty" of which the poet W. B. Yeats wrote. The liberal arts, so often thought to dwell in a remote ivory tower, embody this dialectic. Wars and…

  14. Pig transgenesis by Sleeping Beauty DNA transposition

    DEFF Research Database (Denmark)

    Jakobsen, Jannik E.; Li, Juan; Kragh, Peter M.;

    2011-01-01

    disease models. In this report, we present transgenic pigs created by Sleeping Beauty DNA transposition in primary porcine fibroblasts in combination with somatic cell nuclear transfer by handmade cloning. Göttingen minipigs expressing green fluorescent protein are produced by transgenesis with DNA...... plasmid DNA. Our findings illustrate critical issues related to DNA transposon-directed transgenesis, including coincidental plasmid insertion and relatively low Sleeping Beauty transposition activity in porcine fibroblasts, but also provide a platform for future development of porcine disease models...... using the Sleeping Beauty gene insertion technology....

  15. Darwin's beautiful notion: sexual selection and the plurality of moral codes.

    Science.gov (United States)

    Tipton, J A

    1999-01-01

    One of the explicit objectives of Darwin's Descent of Man, and Selection in Relation to Sex was to explain cultural differences seen in human beings. Such an explanation, Darwin believed, was to rest upon an understanding of sexual selection. I examine the role that the beautiful plays within the mechanism of sexual selection as it works to differentiate isolated groups. It is suggested that an examination of the relationship between sexual selection and artificial selection--a relationship mediated by the beautiful--will illuminate key issues of the Descent as well as contemporary debates regarding the relationship between evolution and ethics. The beautiful, originally rooted in sexual selection, can become de-coupled from sexual selection and utilized in some selective process which is conscious. PMID:11004944

  16. Particle identification for beauty physics

    Energy Technology Data Exchange (ETDEWEB)

    Ludlam, T.

    1987-01-01

    We look briefly at the requirements for particle identification for possible beauty experiments at the Tevatron, both in the fixed target and the collider mode. Techniques presently in use in high energy physics experiments, and under development, should make sensitive experiments feasible. However, in all cases the present state of the art must be advanced to meet the necessary requirements for segmentation andor rate capability. The most fundamentally difficult challenges appear to be the efficient tagging of soft electrons (for the collider experiment) and the need to handle interaction rates up to /approximately/ 10/sub 9/ HZ in the fixed target mode. In both cases we can find ''in principle'' demonstrations that the requirements can be met. We have considered only the most basic prooperties of detectors, however, and the real answers will come from careful studies of details. 20 refs., 10 figs.

  17. My beautiful hometown Gao Chun

    Institute of Scientific and Technical Information of China (English)

    王晟

    2010-01-01

    @@ In the southwestern part of Jiangsu Province,the southern suburbs of the ancient city of Nanjing,there is a magical and quaint land, distributing the heat,revealing fascinating charm like a brilliant pearl. It has natural ecology(自然生态),beautiful scenery and rich resources(富饶的资源)and has got the famous reputation of being a land of fish and rice(鱼米之乡 ).This is Gaochun, the Jiangnan Holy Land (江南胜地) called by the Qianlong emperor(乾隆皇帝)in Qing Dynasty and now it is one of the Top 100 Counties(百强县之一), Red Sun Corporation and Wu Jiazui Jinling First Richest Village belong to Gao Chun.

  18. Experimental situation of beauty oscillations

    International Nuclear Information System (INIS)

    The experimental situation of the evidences for beauty oscillations is reviewed. After a brief description of the formalism the results from the CERN proton-antiproton collider are described and compared with the results from electron-positron colliders. Whereas the experiments on the continuum measure a mixture of χs and χd the experiments on the Υ (4s) are only sensitive to χd. A forecast for 1992 is given and a method is described which allows to measure χs. A precision measurement of χs would allow to further constrain the CKM matrix and would eventually lead to a determination of the phase in the matrix

  19. Beautiful mirrors at the LHC.

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, K.; Shepherd, W.; Tait, T. M. P.; Vega-Morales, R.; High Energy Physics; Northwestern Univ; Univ. of California at Irvine

    2010-01-01

    We explore the 'Beautiful Mirrors' model, which aims to explain the measured value of A{sub FB}{sup b}, discrepant at the 2.9{sigma} level. This scenario introduces vector-like quarks which mix with the bottom, subtly affecting its coupling to the Z. The spectrum of the new particles consists of two bottom-like quarks and a charge -4/3 quark, all of which have electroweak interactions with the third generation. We explore the phenomenology and discovery reach for these new particles at the LHC, exploring single mirror quark production modes whose rates are proportional to the same mixing parameters which resolve the A{sub FB}{sup b} anomaly. We find that for mirror quark masses {approx}< 500 GeV, a 14 TeV LHC with 300 fb{sup -1} is required to reasonably establish the scenario and extract the relevant mixing parameters.

  20. Exhibition - Mathematics, A Beautiful Elsewhere

    CERN Multimedia

    2011-01-01

    From 21 October 2011 to 18 March 2012, the Fondation Cartier pour l’art contemporain will present the exhibition Mathematics: A Beautiful Elsewhere, an exhibition developed in association with the Institut des Hautes Études Scientifiques (IHÉS) and under the patronage of UNESCO. For this unprecedented event, the foundation invited mathematicians to work with artists with whom it has previously worked to create an exhibition that allows visitors to see, hear, do, interpret and think about mathematics. By bringing mathematics into its premises, the Fondation Cartier is itself undergoing the “sudden change of scenery” described by mathematician Alexandre Grothendieck. More information is available here. Fondation Cartier pour l’art contemporain 261, boulevard Raspail 75014 Paris http://fondation.cartier.com Private Visit For professors, researchers and all the staff of Mathematics departments...

  1. Past and Future Perfect? Beauty, Affect and Hope

    OpenAIRE

    Coleman, Rebecca

    2010-01-01

    This article engages with and draws on what have been called two recent “turns” in feminist theory: to beauty and to affect. While much feminist research has concentrated on the beauty industry, where beauty is conceived as a series of economic, social and cultural practices, the authors suggest that beauty should also be understood as an embodied affective process. The authors’ focus is on understanding the conceptions of beauty that emerged in their own empirical work with white British gir...

  2. Is beauty skin deep – an approach to a beautiful face

    Directory of Open Access Journals (Sweden)

    Neerja Puri

    2014-07-01

    Full Text Available Everyone dreams of a beautiful and flawless face but true beauty is God given gift. Plastic surgery and various filler techniques can just highlight certain features and are just the temporary procedures. Features that further enhance the attractiveness of a beautiful face are the hair, skin, and teeth. These areas are the easiest to routinely enhance. There are many methods of facial sculpting including botulinum toxin, fillers and various other invasive plastic surgery techniques.

  3. Is beauty skin deep – an approach to a beautiful face

    OpenAIRE

    Neerja Puri

    2014-01-01

    Everyone dreams of a beautiful and flawless face but true beauty is God given gift. Plastic surgery and various filler techniques can just highlight certain features and are just the temporary procedures. Features that further enhance the attractiveness of a beautiful face are the hair, skin, and teeth. These areas are the easiest to routinely enhance. There are many methods of facial sculpting including botulinum toxin, fillers and various other invasive plastic surgery techniques.

  4. The DREAM complex mediates GIST cell quiescence and is a novel therapeutic target to enhance imatinib-induced apoptosis.

    Science.gov (United States)

    Boichuk, Sergei; Parry, Joshua A; Makielski, Kathleen R; Litovchick, Larisa; Baron, Julianne L; Zewe, James P; Wozniak, Agnieszka; Mehalek, Keith R; Korzeniewski, Nina; Seneviratne, Danushka S; Schöffski, Patrick; Debiec-Rychter, Maria; DeCaprio, James A; Duensing, Anette

    2013-08-15

    Gastrointestinal stromal tumors (GIST) can be successfully treated with imatinib mesylate (Gleevec); however, complete remissions are rare and patients frequently achieve disease stabilization in the presence of residual tumor masses. The clinical observation that discontinuation of treatment can lead to tumor progression suggests that residual tumor cells are, in fact, quiescent and, therefore, able to re-enter the cell-division cycle. In line with this notion, we have previously shown that imatinib induces GIST cell quiescence in vitro through the APC(CDH1)-SKP2-p27(Kip1) signaling axis. Here, we provide evidence that imatinib induces GIST cell quiescence in vivo and that this process also involves the DREAM complex, a multisubunit complex that has recently been identified as an additional key regulator of quiescence. Importantly, inhibition of DREAM complex formation by depletion of the DREAM regulatory kinase DYRK1A or its target LIN52 was found to enhance imatinib-induced cell death. Our results show that imatinib induces apoptosis in a fraction of GIST cells while, at the same time, a subset of cells undergoes quiescence involving the DREAM complex. Inhibition of this process enhances imatinib-induced apoptosis, which opens the opportunity for future therapeutic interventions to target the DREAM complex for more efficient imatinib responses. PMID:23786773

  5. Combined 2-deoxy glucose and metformin improves therapeutic efficacy of sodium-iodide symporter-mediated targeted radioiodine therapy in breast cancer cells

    Directory of Open Access Journals (Sweden)

    Chatterjee S

    2015-08-01

    Full Text Available Sushmita Chatterjee, Nirmal Thaker, Abhijit DeMolecular Functional Imaging Laboratory, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai, IndiaAbstract: Radiosensitization using either metformin or 2-deoxy-d-glucose (2-DG in various cancer cells has been reported. The present study reveals novel information on combining these drugs to enhance radiosensitization effect in breast cancer (BC cells. Responses to low-dose Cobalt60 radiation, as well as a newly emerged radioiodine therapy target for BC, that is, sodium-iodide symporter (NIS or SLC5A5 protein, are tested. As therapeutic potential of NIS in BC is often limited due to low uptake and fast efflux rate of iodine, the scope of these two radiosensitizers to further improve NIS-mediated 131I therapeutic efficacy is explored. Two BC cell lines, MCF-7, and MDA MB231 are tested to optimize minimal drug doses required for radiosensitization. A combination of 2 mM metformin and 20 mM 2-DG with 2 grey (Gy Cobalt60 radiation shows significant radiosensitization effect (P=0.0002. In cells treated with the combination therapy, increased γH2A.X foci formation was noted. Further, MCF-7 BC cells overexpressing NIS (MCF-7 NIS was established, and using the optimized drug concentrations, significant radiosensitization (P=0.0019 by 50 µ Ci 131I usage was found to be the case as well. Apoptosis data corroborates with the result of clonogenic assay showing significant increase in apoptotic population upon dual drug-mediated radiosensitization. In case of metformin treatment, lowered adenosine triphosphate (ATP content of the cell has been observed. The encouraging radiosensitization effect observed using combined 2-DG and metformin may aid in reducing Cobalt60 radiation exposure or for targeted radioiodine therapy in BC cells with NIS expression. This study indicates high potential of this drug combination in sensitizing BC cells for NIS-mediated

  6. Screening compounds with a novel high-throughput ABCB1-mediated efflux assay identifies drugs with known therapeutic targets at risk for multidrug resistance interference.

    Directory of Open Access Journals (Sweden)

    Megan R Ansbro

    Full Text Available ABCB1, also known as P-glycoprotein (P-gp or multidrug resistance protein 1 (MDR1, is a membrane-associated multidrug transporter of the ATP-binding cassette (ABC transporter family. It is one of the most widely studied transporters that enable cancer cells to develop drug resistance. Reliable high-throughput assays that can identify compounds that interact with ABCB1 are crucial for developing new therapeutic drugs. A high-throughput assay for measuring ABCB1-mediated calcein AM efflux was developed using a fluorescent and phase-contrast live cell imaging system. This assay demonstrated the time- and dose-dependent accumulation of fluorescent calcein in ABCB1-overexpressing KB-V1 cells. Validation of the assay was performed with known ABCB1 inhibitors, XR9576, verapamil, and cyclosporin A, all of which displayed dose-dependent inhibition of ABCB1-mediated calcein AM efflux in this assay. Phase-contrast and fluorescent images taken by the imaging system provided additional opportunities for evaluating compounds that are cytotoxic or produce false positive signals. Compounds with known therapeutic targets and a kinase inhibitor library were screened. The assay identified multiple agents as inhibitors of ABCB1-mediated efflux and is highly reproducible. Among compounds identified as ABCB1 inhibitors, BEZ235, BI 2536, IKK 16, and ispinesib were further evaluated. The four compounds inhibited calcein AM efflux in a dose-dependent manner and were also active in the flow cytometry-based calcein AM efflux assay. BEZ235, BI 2536, and IKK 16 also successfully inhibited the labeling of ABCB1 with radiolabeled photoaffinity substrate [(125I]iodoarylazidoprazosin. Inhibition of ABCB1 with XR9576 and cyclosporin A enhanced the cytotoxicity of BI 2536 to ABCB1-overexpressing cancer cells, HCT-15-Pgp, and decreased the IC50 value of BI 2536 by several orders of magnitude. This efficient, reliable, and simple high-throughput assay has identified ABCB1

  7. The Relation between the ideal of beauty and dependent beauty in Kant's philosophy

    Directory of Open Access Journals (Sweden)

    Javad Amin

    2015-10-01

    Full Text Available Kant organizes his analysis in terms of four moments of the judgment of taste, each of which is supposed to contribute something essential to the complete exposition of the beautiful in "Critique of Judgment". He, in the third moment, based on the key concept analysis of "purposiveness", reaches to the beauty definition "a purposiveness without a purpose" (subjective purposiveness. Below this moment, two concepts of "dependent beauty" and "the ideal of beauty" also arises that aesthetic judgment in both of them is based on an objective purposiveness and a concept indicating nature of the object and the perfection of the object that is considered as default for judgment. This default in dependent beauty is perfection of the object and in the ideal of beauty is a concept from the sum of the rational idea and the aesthetic normal idea, but this point of view is in contradiction with the principle of Kant's aesthetic, which judgment of the beautiful just relies on the subjective purposiveness. This article reviewing the concept of purposiveness and the type of subjective purposiveness in the ideal of beauty and dependent beauty, attempts to explain the aesthetic value of these concepts and their differences and similarities, and finally to determine the position of these two concepts in Kant's philosophy.

  8. Neuroaesthetics and the trouble with beauty.

    Directory of Open Access Journals (Sweden)

    Bevil R Conway

    Full Text Available Neuroscience is increasingly being called upon to address issues within the humanities. We discuss challenges that arise, relating to art and beauty, and provide ideas for a way forward.

  9. Neuroaesthetics and the trouble with beauty.

    Science.gov (United States)

    Conway, Bevil R; Rehding, Alexander

    2013-01-01

    Neuroscience is increasingly being called upon to address issues within the humanities. We discuss challenges that arise, relating to art and beauty, and provide ideas for a way forward. PMID:23526878

  10. Charm, beauty and top at HERA

    Science.gov (United States)

    Behnke, O.; Geiser, A.; Lisovyi, M.

    2015-09-01

    Results on open charm and beauty production and on the search for top production in high-energy electron-proton collisions at HERA are reviewed. This includes a discussion of relevant theoretical aspects, a summary of the available measurements and measurement techniques, and their impact on improved understanding of QCD and its parameters, such as parton density functions and charm- and beauty-quark masses. The impact of these results on measurements at the LHC and elsewhere is also addressed.

  11. Hadronic couplings of open beauty states

    International Nuclear Information System (INIS)

    Strong interaction coupling parameters of particles with beauty quantum number are obtained using dispersion sum rules in various forms, e.g. current algebra sum rules, superconvergence sum rules and finite energy sum rules etc. These sum rules lead to a set of algebraic relations among masses and coupling constants. We compare the hadronic couplings of beautiful particles as obtained from various techniques and discuss their implications on the hadronic production of these states. (author)

  12. Success of Celebrities: Talent, Intelligence or Beauty?

    OpenAIRE

    Olivier Gergaud; Victor Ginsburgh; Florine Livat

    2012-01-01

    We analyze the Celebrity 100 annual list of the world's most “powerful celebrities†compiled and published by Forbes Magazine. The lists provide an interesting collection of people, that includes their earnings, and the perception of citizens concerning the attributes that made them become celebrities. We analyze the relationship between their earnings and the perceptions on their intelligence, talent, beauty and other attributes, and show that though beauty plays a role, intelligence and ...

  13. Charm, Beauty and Top at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Behnke, O.; Geiser, A.; Lisovyi, M.

    2015-06-15

    Results on open charm and beauty production and on the search for top production in high-energy electron-proton collisions at HERA are reviewed. This includes a discussion of relevant theoretical aspects, a summary of the available measurements and measurement techniques, and their impact on improved understanding of QCD and its parameters, such as parton density functions and charm- and beauty-quark masses. The impact of these results on measurements at the LHC and elsewhere is also addressed.

  14. Charm, Beauty and Top at HERA

    CERN Document Server

    Behnke, O; Lisovyi, M

    2015-01-01

    Results on open charm and beauty production and on the search for top production in high-energy electron-proton collisions at HERA are reviewed. This includes a discussion of relevant theoretical aspects, a summary of the available measurements and measurement techniques, and their impact on improved understanding of QCD and its parameters, such as parton density functions and charm- and beauty-quark masses. The impact of these results on measurements at the LHC and elsewhere is also addressed.

  15. The New Wellness. When Beauty Means Health

    OpenAIRE

    Vaccaro Concetta Maria

    2010-01-01

    Behind the new and increasingly broaden selfcare behaviours, and the corresponding explosion of wellness consumption, lies a new conception of health that gives centrality to the dimension of psychological well-being and considers to be and feel beautiful as a prerequisite in order to attain this achievement. Individual empowerment in self care also affects people's engagement in activities, and then the option for consumption choices, related to fitness, healthy eating and beauty treatments,...

  16. Lifetimes of charm and beauty hadrons

    International Nuclear Information System (INIS)

    Recent results on the lifetimes of charm and beauty hadrons at the LEP collider experiment and at the fixed target experiments E653 are reviewed and discussed. The world average of b lifetime is now =1.29±0.05 ps. The exclusive lifetime measurements for b+, b-, b0 are presented. The lifetime difference among the different species of charm and of beauty hadrons are discussed. (author) 25 refs., 13 figs., 12 tabs

  17. Beautiful mesons from QCD spectral sum rules

    Energy Technology Data Exchange (ETDEWEB)

    Narison, S. (OPM, Univ. Montpellier 2, 34 (France))

    1991-08-01

    We discuss the beautiful meson from the point of view of the QCD spectral sum rules (QSSR). The bottom quark mass and the mixed light quark-gluon condensates are determined quite accurately. The decay constant f{sub B} is estimated and we present some arguments supporting this result. The decay constants and the masses of the other members of the beautiful meson family are predicted. (orig.).

  18. On the Beautiful and the Ugly

    OpenAIRE

    Herman Parret

    2011-01-01

    Classical aesthetics sees the experience of the beautiful as an anthropological necessity. But, in fact, the beautiful is rather the central category designating classical art, and one can question the relevance of this category considering contemporary art. The reference term most frequently used for contemporary art is interesting: works of art solicit the interests of my faculties (the cognitive-intellectual, the pragmatic community-oriented moral, the affective aesthetic faculties). It is...

  19. Charm, Beauty and Top at HERA

    International Nuclear Information System (INIS)

    Results on open charm and beauty production and on the search for top production in high-energy electron-proton collisions at HERA are reviewed. This includes a discussion of relevant theoretical aspects, a summary of the available measurements and measurement techniques, and their impact on improved understanding of QCD and its parameters, such as parton density functions and charm- and beauty-quark masses. The impact of these results on measurements at the LHC and elsewhere is also addressed.

  20. Introduction to beauty-hadron physics

    International Nuclear Information System (INIS)

    These lectures discuss methods for analyzing the decay of beauty hadrons (B mesons and beauty baryons) produced in pp interactions. At the c.m. energies around 14 TeV planned for the Large Hadron Collider (LHC) at CERN, the B meson production rate is expected to be ca 105 larger than in an e+e- B factory. The pp collider could then offer, in principle, important advantages. However, the detection of beauty hadrons produced in a pp collider will be a task of great complexity. In particular, the triggering difficulties of events in a large background will be one of the major problems. Therefore, it would be useful to discuss the various aspects that can be investigated in beauty physics arising from pp interactions. It is first described the general features of the formalisms of B mixing and search for CP violation in the meson decays. Then the specific problems appearing for beauty hadrons produced in pN interactions are considered. Some comparison between investigations which could be carried out with B factories and pp colliders are also mentioned, although this is not the main concern of these lectures. Finally it is also presented some elements of beauty baryon decays which can only be studied efficiently by means of pN interaction

  1. Examination of nanoformulated crosslinked polymers complexed with copper/zinc superoxide dismutase as a therapeutic strategy for angiotensin II-mediated hypertension

    Science.gov (United States)

    Savalia, Krupa

    Excessive generation of superoxide (O2·-) has been extensively implicated as a signaling molecule in cardiovascular pathologies, including hypertension. As a major risk factor for myocardial infarction, stroke, and heart failure, the morbidity and mortality associated with hypertension is a worldwide epidemic. Although there are several standard therapies that effectively lower blood pressure, many hypertensive patients have uncontrolled blood pressure despite taking available medications. Thus, there is a necessity to develop new pharmacotherapies that target novel molecular effectors (e.g. O2·-) that have been implicated to be integral in the pathogenesis of hypertension. To overcome the failed therapeutic impact of currently available antioxidants in cardiovascular disease, we developed a nanomedicine-based delivery system for the O2 ·- scavenging enzyme, copper/zinc superoxide dismutase (CuZnSOD), in which CuZnSOD protein is electrostatically bound to poly-L-lysine (PLL 50)-polyethylene glycol (PEG) block co-polymer to form CuZnSOD nanozyme. Different formulations of CuZnSOD nanozyme are covalently stabilized by either reducible or non-reducible crosslinked bonds between the PLL50-PEG polymers. Herein, we tested the overall hypothesis that PLL50-PEG CuZnSOD nanozyme delivers active CuZnSOD protein to neurons and decreases blood pressure in a model of Angll-dependent hypertension. As determined by electron paramagnetic resonance (EPR) spectroscopy, nanozymes retain full SOD enzymatic activity. Furthermore, non-reducible crosslinked nanozyme delivers active CuZnSOD protein to central neurons in culture (CATH.a neurons) without inducing significant neuronal toxicity. In vivo studies conducted in Angll-mediated hypertensive adult male C57BL/6 mice demonstrate that the non-reducible crosslinked nanozyme significantly attenuates blood pressure when given directly into the brain and prevents the further increase in hypertension when intravenously (IV) administered

  2. Materialised Ideals Sizes and Beauty

    Directory of Open Access Journals (Sweden)

    Kirsi Laitala

    2011-04-01

    Full Text Available Today’s clothing industry is based on a system where clothes are made in ready-to-wear sizes and meant to fit most people. Studies have pointed out that consumers are discontent with the use of these systems: size designations are not accurate enough to find clothing that fits, and different sizes are poorly available. This article discusses in depth who these consumers are, and which consumer groups are the most dissatisfied with today’s sizing systems. Results are based on a web survey where 2834 Nordic consumers responded, complemented with eight in-depth interviews, market analysis on clothing sizes and in-store trouser size measurements. Results indicate that higher shares of the consumers who have a body out of touch with the existing beauty ideals express discontentment with the sizing systems and the poor selection available. In particular, large women, very large men, and thin, short men are those who experience less priority in clothing stores and have more difficulties in finding clothes that fit. Consumers tend to blame themselves when the clothes do not fit their bodies, while our study points out that the industry is to blame as they do not produce clothing for all customers.

  3. The Ten Most Beautiful Experiments

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, George [The New York Times

    2010-10-20

    "Science in the 21st century has become industrialized. The experiments so often celebrated in the newspapers - sequencing the genome, proving the existence of the top quark, discovering a new planet by analyzing the wobble of a distant start - cost millions of dollars. They generate terabytes of data to be analyzed by supercomputers, calculating factories that spew out so much heat that they are equipped with cooling stacks and consume the energy of a small town. The experiments are carried out by research teams that have grown to the size of small corporations. But until very recently the most earth-shaking science came from individual pairs of hands. From a single mind confronting the unknown. The great experiments that mark the edges of our understanding were most often performed by one or two scientists and usually on a tabletop. Computation, if there was any, was carried out on paper or later with a slide rule. These experiments were designed and conducted with such straightforward elegance that they deserve to be called beautiful." (excerpt from the slide presentation accompanying the video)

  4. Beauty Meson Decays To Charmonium

    CERN Document Server

    Ershov, A V

    2001-01-01

    We study decays of beauty (B) mesons into the final states containing charmonium mesons. The data were collected by the CLEO experiment at the Cornell Electron Storage Ring from 1990 to 1999. First, we describe a technique that significantly improves the reconstruction efficiency for decays of J/ y and y (2S) mesons into a pair of leptons. This reconstruction method is used in all the analyses presented in this dissertation. Then we present a study of B decays to the χc 1 and χc2 charmonium states and compare our results with the predictions of different theoretical models of charmonium production. After that we report the first observation of the decay B → J/ y &phis;K, which is the first B meson decay requiring a creation of an additional ss¯ quark pair. Then we measure the B0 and B+ meson masses from B0 → y (′) K0S and B+ → y (′) K+ decays. The method employed eliminates the dominant systematic uncertainty associated w...

  5. Trypanosoma cruzi-elicited CD8+ T cell-mediated myocarditis: chemokine receptors and adhesion molecules as potential therapeutic targets to control chronic inflammation?

    Directory of Open Access Journals (Sweden)

    Joseli Lannes-Vieira

    2003-04-01

    Full Text Available In Chagas disease, during the acute phase, the establishment of inflammatory processes is crucial for Trypanosoma cruzi control in target tissues and for the establishment of host/parasite equilibrium. However, in about 30% of the patients, inflammation becomes progressive, resulting in chronic disease, mainly characterized by myocarditis. Although several hypothesis have been raised to explain the pathogenesis of chagasic myocardiopathy, including the persistence of the parasite and/or participation of autoimmune processes, the molecular mechanisms underlying the establishment of the inflammatory process leading to parasitism control but also contributing to the maintenance of T. cruzi-elicited chronic myocarditis remain unsolved. Trying to shed light on these questions, we have for several years been working with murine models for Chagas disease that reproduce the acute self-resolving meningoencephalitis, the encephalitis resulting of reactivation described in immunodeficient individuals, and several aspects of the acute and chronic myocarditis. In the present review, our results are summarized and discussed under the light of the current literature. Furthermore, rational therapeutic intervention strategies based on integrin-mediated adhesion and chemokine receptor-driven recruitment of leukocytes are proposed to control T. cruzi-elicited unbalanced inflammation.

  6. 7 CFR 650.24 - Scenic beauty (visual resource).

    Science.gov (United States)

    2010-01-01

    ... Scenic beauty (visual resource). (a) Background. Contributions to scenic beauty are a normal product of..., and farmsteads; siting or positioning of structures and buildings to be in harmony with the...

  7. Hadroproduction characteristics of charm and beauty

    International Nuclear Information System (INIS)

    In this article the authors review the present status of their knowledge on the hadroproduction characteristics of charm and beauty. During a brief description of the properties of all charm and beauty particles reportedly observed in hadron-hadron experiments they discuss the strengths and weaknesses of the various experimental techniques. In particular they emphasise the quantitative problems associated with nuclear target experiments and show the progress that is being made in understanding the A-dependence problem. Focussing on charm cross sections the authors see that the data are becoming sufficiently good to give us a reliable and coherent picture which provides a serious test of the QCD fusion model. This same fusion model is then used with existing beauty cross section determinations to make some extrapolations. Finally, a few remaining puzzles and curiosities are underlined

  8. On the Beautiful and the Ugly

    Directory of Open Access Journals (Sweden)

    Herman Parret

    2011-01-01

    Full Text Available Classical aesthetics sees the experience of the beautiful as an anthropological necessity. But, in fact, the beautiful is rather the central category designating classical art, and one can question the relevance of this category considering contemporary art. The reference term most frequently used for contemporary art is interesting: works of art solicit the interests of my faculties (the cognitive-intellectual, the pragmatic community-oriented moral, the affective aesthetic faculties. It is interesting to notice that the categories of the beautiful and the ugly have an axiological-moral value. It looks as if the qualities of contemporary art works are judged according to the intensity of the impact on the interests of our faculties. It reveals important, in this respect, to distinguish the ugly from the sublime and the monstrous. Kant’s Third Critique is of some importance in defining these categories.

  9. On the Beauty in Keats’s Ode to Autumn

    Institute of Scientific and Technical Information of China (English)

    谭凯

    2011-01-01

    Keats’s poems are famous for beauty,and Ode to Autumn is generally regarded as one of his most beautiful poems.In this ode,Keats presents a vivid picture of the harvesting autumn,in which many forms of beauty can be captured.The present paper attempts to conduct an analysis of the beauty in Keats’s Ode to Autumn,hopefully it could help readers better understand Keats and his works.

  10. Therapeutic ultrasound

    Energy Technology Data Exchange (ETDEWEB)

    Crum, Lawrence A [Center for Industrial and Medical Ultrasound, 1013 NE 40th Street, University of Washington, Seattle, WA 98105 (United States)

    2004-01-01

    The use of ultrasound in medicine is now quite commonplace, especially with the recent introduction of small, portable and relatively inexpensive, hand-held diagnostic imaging devices. Moreover, ultrasound has expanded beyond the imaging realm, with methods and applications extending to novel therapeutic and surgical uses. These applications broadly include: tissue ablation, acoustocautery, lipoplasty, site-specific and ultrasound mediated drug activity, extracorporeal lithotripsy, and the enhancement of natural physiological functions such as wound healing and tissue regeneration. A particularly attractive aspect of this technology is that diagnostic and therapeutic systems can be combined to produce totally non-invasive, imageguided therapy. This general lecture will review a number of these exciting new applications of ultrasound and address some of the basic scientific questions and future challenges in developing these methods and technologies for general use in our society. We shall particularly emphasize the use of High Intensity Focused Ultrasound (HIFU) in the treatment of benign and malignant tumors as well as the introduction of acoustic hemostasis, especially in organs which are difficult to treat using conventional medical and surgical techniques. (amum lecture)

  11. Therapeutic ultrasound

    International Nuclear Information System (INIS)

    The use of ultrasound in medicine is now quite commonplace, especially with the recent introduction of small, portable and relatively inexpensive, hand-held diagnostic imaging devices. Moreover, ultrasound has expanded beyond the imaging realm, with methods and applications extending to novel therapeutic and surgical uses. These applications broadly include: tissue ablation, acoustocautery, lipoplasty, site-specific and ultrasound mediated drug activity, extracorporeal lithotripsy, and the enhancement of natural physiological functions such as wound healing and tissue regeneration. A particularly attractive aspect of this technology is that diagnostic and therapeutic systems can be combined to produce totally non-invasive, imageguided therapy. This general lecture will review a number of these exciting new applications of ultrasound and address some of the basic scientific questions and future challenges in developing these methods and technologies for general use in our society. We shall particularly emphasize the use of High Intensity Focused Ultrasound (HIFU) in the treatment of benign and malignant tumors as well as the introduction of acoustic hemostasis, especially in organs which are difficult to treat using conventional medical and surgical techniques. (amum lecture)

  12. Therapeutic efficacy of improved α-fetoprotein promoter-mediated tBid delivered by folate-PEI600-cyclodextrin nanopolymer vector in hepatocellular carcinoma

    International Nuclear Information System (INIS)

    SNPs in human AFP promoter are associated with serum AFP levels in hepatocellular carcinoma (HCC), suggesting that AFP promoter variants may generate better transcriptional activities while retaining high specificity to AFP-producing cells. We sequenced human AFP promoters, cloned 15 different genotype promoters and tested their reporter activities in AFP-producing and non-producing cells. Among various AFP variant fragments tested, EA4D exhibited the highest reporter activity and thus was selected for the further study. EA4D was fused with tBid and coupled with nano-particle vector (H1) to form pGL3-EA4D-tBid/H1. pGL3-EA4D-tBid/H1 could express a high level of tBid while retain the specificity to AFP-producing cells. In a HCC tumor model, application of pGL3-EA4D-tBid/H1 significantly inhibited the growth of AFP-producing-implanted tumors with minimal side-effects, but had no effect on non-AFP-producing tumors. Furthermore, pGL3-EA4D-tBid/H1 could significantly sensitize HCC cells to sorafenib, an approved anti-HCC agent. Collectively, pGL3-EA4D-tBid/H1, a construct with the AFP promoter EA4D and the novel H1 delivery system, can specifically target and effectively suppress the AFP-producing HCC. This new therapeutic tool shows little toxicity in vitro and in vivo and it should thus be safe for further clinical tests. - Highlights: • The nano-particle vector H1 has advantages in mediating gene therapy construct pGL3-EA4D-tBid for HCC treatment. • pGL3-EA4D-tBid/H1, a construct with the AFP promoter EA4D, can specifically target the AFP-producing HCC. • pGL3-EA4D-tBid/H1effectively suppresses the proliferation and growth of AFP-producing HCC. • This novel pGL3-EA4D-tBid/H1 therapeutic tool shows little toxicity in vitro and in vivo

  13. Therapeutic efficacy of improved α-fetoprotein promoter-mediated tBid delivered by folate-PEI600-cyclodextrin nanopolymer vector in hepatocellular carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Hu, Bao-guang [Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR (Hong Kong); Department of Gastrointestinal Surgery, the Affiliated Hospital of Binzhou Medical University, Binzhou, Shandong (China); Liu, Li-ping [Department of Hepatobiliary and Pancreas Department of Hepatobiliary Surgery, the Second Clinical Medical College of Jinan University (Shenzhen People' s Hospital), Shenzhen, Guangdong Province (China); Chen, George G., E-mail: gchen@cuhk.edu.hk [Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR (Hong Kong); Ye, Cai Guo; Leung, Kevin K.C.; Ho, Rocky L.K.; Lin, Marie C.; Lai, Paul B.S. [Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR (Hong Kong)

    2014-06-10

    SNPs in human AFP promoter are associated with serum AFP levels in hepatocellular carcinoma (HCC), suggesting that AFP promoter variants may generate better transcriptional activities while retaining high specificity to AFP-producing cells. We sequenced human AFP promoters, cloned 15 different genotype promoters and tested their reporter activities in AFP-producing and non-producing cells. Among various AFP variant fragments tested, EA4D exhibited the highest reporter activity and thus was selected for the further study. EA4D was fused with tBid and coupled with nano-particle vector (H1) to form pGL3-EA4D-tBid/H1. pGL3-EA4D-tBid/H1 could express a high level of tBid while retain the specificity to AFP-producing cells. In a HCC tumor model, application of pGL3-EA4D-tBid/H1 significantly inhibited the growth of AFP-producing-implanted tumors with minimal side-effects, but had no effect on non-AFP-producing tumors. Furthermore, pGL3-EA4D-tBid/H1 could significantly sensitize HCC cells to sorafenib, an approved anti-HCC agent. Collectively, pGL3-EA4D-tBid/H1, a construct with the AFP promoter EA4D and the novel H1 delivery system, can specifically target and effectively suppress the AFP-producing HCC. This new therapeutic tool shows little toxicity in vitro and in vivo and it should thus be safe for further clinical tests. - Highlights: • The nano-particle vector H1 has advantages in mediating gene therapy construct pGL3-EA4D-tBid for HCC treatment. • pGL3-EA4D-tBid/H1, a construct with the AFP promoter EA4D, can specifically target the AFP-producing HCC. • pGL3-EA4D-tBid/H1effectively suppresses the proliferation and growth of AFP-producing HCC. • This novel pGL3-EA4D-tBid/H1 therapeutic tool shows little toxicity in vitro and in vivo.

  14. 75 FR 33763 - Beauty and Cosmetics Trade Mission to India

    Science.gov (United States)

    2010-06-15

    ... International Trade Administration Beauty and Cosmetics Trade Mission to India AGENCY: International Trade... Beauty and Cosmetics Trade Mission to India (New Delhi, Mumbai and Bangalore), November 15-19, 2010. Led.... The cosmetics/beauty industry is one of the booming retail sectors in India with very strong...

  15. 75 FR 21595 - Beauty and Cosmetics Trade Mission to India

    Science.gov (United States)

    2010-04-26

    ... International Trade Administration Beauty and Cosmetics Trade Mission to India AGENCY: International Trade... Beauty and Cosmetics Trade Mission to India (New Delhi, Mumbai and Bangalore), November 15-19, 2010. Led... Indian market. The cosmetics/ beauty industry is one of the booming retail sectors in India with...

  16. Walking in Beauty: An American Indian Perspective on Social Justice

    Science.gov (United States)

    Eason, Evan Allen; Robbins, Rockey

    2012-01-01

    The purpose of this article is to introduce "walking in beauty," an American Indian spiritual perspective related to social justice that emphasizes beauty, harmony, connectedness/unity of experience, and imagination. Walking in beauty includes 3 processes: embodiment, creativity, and appreciation of the sublime. Recommendations are offered for…

  17. Beautiful skin%美丽肌肤

    Institute of Scientific and Technical Information of China (English)

    胡敏

    2012-01-01

    介绍了皮肤皱纹生成的机理,抗皱有效成分、作用机理以及皮肤的抗衰老护理。介绍了一些美容食品、抗老化美容成分以及最具潜力的原料来源。%The mechanism of skin wrinkle formation,the active ingredients of anti-aging,the mechanism of action as well as skin anti-aging care were introduced here.Some beautiful foods,anti-aging beautiful ingredients and the most interesting source of feed were also related.

  18. Fixed Target Beauty Physics Experimental Programs

    International Nuclear Information System (INIS)

    The current and near term future fixed target physics efforts in observing particles with open beauty are reviewed. This includes a compilation of the non-observation upper limits and the observation of both upsilon and b-states. A short discussion of the theoretical predictions for the hadro-produced beauty pairs is included. The major part of this review is devoted to the techniques and tricks employed, a survey of the current and proposed experiments. A personal summary of the experimental prospects concludes this report. 28 refs., 26 figs

  19. A historical note on the beauty contest

    OpenAIRE

    Büren, Christoph; Frank, Björn; Nagel, Rosemarie

    2012-01-01

    Alain Ledoux, who was one of over 6,000 chess players taking part in Bühren and Frank´s (2012) online Beauty Contest experiment, turned out to be the forgotten inventor of that game. We reconstruct the birth of the Beauty Contest. In section 1 of our note, its first two authors outline the history of the game that metamorphosed into the famous guessing game experiment which was first run in the lab by Rosemarie Nagel. In section 2, Rosemarie Nagel adds further remarks and thoughts about the d...

  20. Old age – „how beautiful to be yourself”

    Directory of Open Access Journals (Sweden)

    Ilona Zakowicz

    2011-12-01

    Full Text Available In every given period one can observe different attitudes towards old age, death and the elderly, which are shown through varied stances and ideas about this specific period of human life. The reality of the XXI century often regarded as “vision-centric” is dominated by the cult of beauty and youth which creates increasingly demanding requirements, related mainly to the attractiveness of appearance, of the body – especially the one belonging to the elderly. The increase in the number of senior citizens compared to the rest of the society that can be witnessed nowadays leads to the elderly being a more carefully examined social group. Mediated by the media discourse the images of the elderly are becoming more common and therefore the author’s attempt at reconstructing the postmodern strategy of the rendering of late adulthood seems to be an interesting and important topic to consider

  1. Beauty meson decays to charmonium

    Science.gov (United States)

    Ershov, Alexey Valerievich

    2001-10-01

    We study decays of beauty (B) mesons into the final states containing charmonium mesons. The data were collected by the CLEO experiment at the Cornell Electron Storage Ring from 1990 to 1999. First, we describe a technique that significantly improves the reconstruction efficiency for decays of J/ y and y (2S) mesons into a pair of leptons. This reconstruction method is used in all the analyses presented in this dissertation. Then we present a study of B decays to the χc 1 and χc2 charmonium states and compare our results with the predictions of different theoretical models of charmonium production. After that we report the first observation of the decay B --> J/ y φK, which is the first B meson decay requiring a creation of an additional ss¯ quark pair. Then we measure the B0 and B+ meson masses from B0 --> y (') K0S and B+ --> y (') K+ decays. The method employed eliminates the dominant systematic uncertainty associated with the previous B meson mass measurements at the e+e- colliders and results in a significant improvement in precision. After that we present a study of three B0 decay modes useful for time-dependent CP asymmetry measurements. In this study we reconstruct B0 --> J/ y K0S , B0 --> χc 1 K0S , and B0 --> J/ y π0 decays. The latter two decay modes are observed for the first time. We describe a K0S --> π0π0 detection technique and its application to the reconstruction of the decay B 0 --> J/ y K0S . Then we present a sensitivity study for the measurement of the mixing-induced CP violation in the neutral B meson system (parameter sin 2β) at CLEO using the method that requires a measurement of the decay time of only one meson in a B0overline B0 pair. Finally, we search for direct CP violation in decays B+/- --> J/ y K+/- and B +/- --> y (2S) K+/- . The results of this search are consistent with the Standard Model expectations and provide the first experimental test of the assumption that direct CP violation is negligible in B --> y (') K decays.

  2. Sleeping Beauty transposon-based system for cellular reprogramming and targeted gene insertion in induced pluripotent stem cells

    Science.gov (United States)

    Grabundzija, Ivana; Wang, Jichang; Sebe, Attila; Erdei, Zsuzsanna; Kajdi, Robert; Devaraj, Anantharam; Steinemann, Doris; Szuhai, Károly; Stein, Ulrike; Cantz, Tobias; Schambach, Axel; Baum, Christopher; Izsvák, Zsuzsanna; Sarkadi, Balázs; Ivics, Zoltán

    2013-01-01

    The discovery of direct cell reprogramming and induced pluripotent stem (iPS) cell technology opened up new avenues for the application of non-viral, transposon-based gene delivery systems. The Sleeping Beauty (SB) transposon is highly advanced for versatile genetic manipulations in mammalian cells. We established iPS cell reprogramming of mouse embryonic fibroblasts and human foreskin fibroblasts by transposition of OSKM (Oct4, Sox2, Klf4 and c-Myc) and OSKML (OSKM + Lin28) expression cassettes mobilized by the SB100X hyperactive transposase. The efficiency of iPS cell derivation with SB transposon system was in the range of that obtained with retroviral vectors. Co-expression of the miRNA302/367 cluster together with OSKM significantly improved reprogramming efficiency and accelerated the temporal kinetics of reprogramming. The iPS cells displayed a stable karyotype, and hallmarks of pluripotency including expression of stem cell markers and the ability to differentiate into embryoid bodies in vitro. We demonstrate Cre recombinase-mediated exchange allowing simultaneous removal of the reprogramming cassette and targeted knock-in of an expression cassette of interest into the transposon-tagged locus in mouse iPS cells. This strategy would allow correction of a genetic defect by site-specific insertion of a therapeutic gene construct into ‘safe harbor’ sites in the genomes of autologous, patient-derived iPS cells. PMID:23275558

  3. Beauty and Brains: Detecting Anomalous Pattern Co-Occurrences

    OpenAIRE

    Bertens, Roel; Vreeken, Jilles; Siebes, Arno

    2015-01-01

    Our world is filled with both beautiful and brainy people, but how often does a Nobel Prize winner also wins a beauty pageant? Let us assume that someone who is both very beautiful and very smart is more rare than what we would expect from the combination of the number of beautiful and brainy people. Of course there will still always be some individuals that defy this stereotype; these beautiful brainy people are exactly the class of anomaly we focus on in this paper. They do not posses intri...

  4. Beauty Clinic Services and Using of Cosmetic for Beauty Clinic Attendees at Jakarta, Indonesia

    OpenAIRE

    raharni budiarto

    2014-01-01

    Cosmetic is one of pharmaceuticals preparation, with the vigorous cosmetic advertising in print media, electronic media or internet, communities are faced with cosmetics advertising, in which mostly are offering for skin care, especially women to get the skin whiter and brighter. Cosmetic advertising based on Ministry of Health regulation no. 386/Menkes/SK/1994. The objective of this study was to know the beauty clinic services and using of cosmetic for beauty clinic attendees and affecting f...

  5. [Study of hyperons and beauty particles

    International Nuclear Information System (INIS)

    The proposed research program is to study the production and decay properties of the hyperons and the beauty hadrons at Fermilab. Since the project was approved in 1989, a lot of progress has been made. This report is a summary of the achievements

  6. Beauty baryon decays: a theoretical overview

    International Nuclear Information System (INIS)

    I overview the theoretical status and recent progress on the calculations of beauty baryon decays focusing on the QCD aspects of the exclusive semi-leptonic Λb → pℓμ decay at large recoil and theoretical challenges of radiative and electro-weak penguin decays Λb → Λγ,Λℓ+ℓ−

  7. Poplus Diversifolia:The Most Beautiful Tree

    Institute of Scientific and Technical Information of China (English)

    ZhanHua

    2004-01-01

    Populus diversifolia,an old and rare tree species,is an only tree variety that can naturally grow into forest in Xinjiang's deserts.It is called "Tokolako"in the Uigur language,meaning"the most beautiful tree".Its extraordinary resistance to drought,sand wind and sanitization enables it to thrive in deserts and gains it repute

  8. Beautiful Minds—For How Long.

    Directory of Open Access Journals (Sweden)

    Lori Marino

    2008-07-01

    Full Text Available Lori Marino reviews the new bookBeautiful Minds, which investigates the "parallel lives" of primates and cetaceans and argues that despite the evolutionary distance of these large-brained mammals, they nevertheless share a capacity for complex communication and social behavior, representing a striking example of convergence in intelligence.

  9. The Beautiful Physics of LHC Run 2

    CERN Document Server

    AUTHOR|(CDS)2108556

    2015-01-01

    Run 2 of the LHC offers some beautiful prospects for new physics, including flavour physics as well as more detailed studies of the Higgs boson and searches for new physics beyond the Standard Model (BSM). One of the possibilities for BSM physics is supersymmetry, and flavour physics plays various important r\\^oles in constraining supersymmetric models.

  10. Beauty as Fit: A Metaphor in Mathematics?

    Science.gov (United States)

    Raman, Manya; Öhman, Lars-Daniel

    2013-01-01

    Beauty, which plays a central role in the practice of mathematics (Sinclair 2002), is almost absent in discussions of school mathematics (Dreyfus and Eisenberg 1986). This is problematic, because students will decide whether or not to continue their studies in mathematics without having an accurate picture of what the subject is about. In order to…

  11. Open Charm and Beauty Production at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Behnke, Olaf [DESY, Notkestrasse 85, 22607 Hamburg (Germany)

    2012-01-15

    A review is provided of open charm and beauty production at HERA and its description by perturbative QCD (pQCD). Four years after the end of the data taking there is still a steady flow of new charm and beauty results from HERA. Among the results reported here are the first combined H1 and ZEUS measurements on the contribution from charm production to deep inelastic scattering (DIS), represented by the structure function F{sub 2}{sup cc{sup {sup M{sup a{sup c{sup r{sup o{sup n{sup }}}}}}}}}, as well as new precise results on the corresponding structure function for beauty production, F{sub 2}{sup bb{sup {sup M{sup a{sup c{sup r{sup o{sup n{sup }}}}}}}}}. Furthermore the situation of charm and beauty production in the photoproduction kinematic regime is reviewed. Since it is a related field also the first hadroproduction results from LHC are presented. A brief outlook is given on open heavy flavour prospects at possible future ep colliders, with a focus on the LHeC.

  12. Why Beautiful People Are More Intelligent

    Science.gov (United States)

    Kanazawa, Satoshi; Kovar, Jody L.

    2004-01-01

    Empirical studies demonstrate that individuals perceive physically attractive others to be more intelligent than physically unattractive others. While most researchers dismiss this perception as a ''bias'' or ''stereotype,'' we contend that individuals have this perception because beautiful people indeed "are" more intelligent. The conclusion that…

  13. Miss International Beauty Pageant in China

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ The 47th Miss International Beauty Pageant, jointly sponsored by China Youth Concern Committee for the Advancement of Health and Physical Culture Development, International Culture Association, Kessles Paris, International Culture Exchange Organization,and co-organized by Beijing Kessles International Culture Media Co., Ltd., will be held in Beijing, China, according to the press conference on March 21.

  14. The Beautiful Physics of LHC Run 2

    OpenAIRE

    Ellis, John

    2014-01-01

    Run 2 of the LHC offers some beautiful prospects for new physics, including flavour physics as well as more detailed studies of the Higgs boson and searches for new physics beyond the Standard Model (BSM). One of the possibilities for BSM physics is supersymmetry, and flavour physics plays various important r\\^oles in constraining supersymmetric models.

  15. Beautiful mass predictions from scalar lattice QCD

    Energy Technology Data Exchange (ETDEWEB)

    Samuel, S.; Moriarty, K.J.M.

    1986-07-31

    Scalar lattice QCD methods are used to accurately predict the masses of hadrons with beauty, that is, states which contain a b quark. These states have not yet been seen in the laboratory. The accuracy of the predictions (approx.=25 MeV) make the calculation a good test of lattice methods as well as providing useful guidance for experimentalists.

  16. Beautiful Minds—For How Long

    OpenAIRE

    Lori Marino

    2008-01-01

    Lori Marino reviews the new bookBeautiful Minds, which investigates the "parallel lives" of primates and cetaceans and argues that despite the evolutionary distance of these large-brained mammals, they nevertheless share a capacity for complex communication and social behavior, representing a striking example of convergence in intelligence.

  17. Natural Tendency towards Beauty in Humans: Evidence from Binocular Rivalry.

    Science.gov (United States)

    Mo, Ce; Xia, Tiansheng; Qin, Kaixin; Mo, Lei

    2016-01-01

    Although human preference for beauty is common and compelling in daily life, it remains unknown whether such preference is essentially subserved by social cognitive demands or natural tendency towards beauty encoded in the human mind intrinsically. Here we demonstrate experimentally that humans automatically exhibit preference for visual and moral beauty without explicit cognitive efforts. Using a binocular rivalry paradigm, we identified enhanced gender-independent perceptual dominance for physically attractive persons, and the results suggested universal preference for visual beauty based on perceivable forms. Moreover, we also identified perceptual dominance enhancement for characters associated with virtuous descriptions after controlling for facial attractiveness and vigilance-related attention effects, which suggested a similar implicit preference for moral beauty conveyed in prosocial behaviours. Our findings show that behavioural preference for beauty is driven by an inherent natural tendency towards beauty in humans rather than explicit social cognitive processes. PMID:26930202

  18. Natural Tendency towards Beauty in Humans: Evidence from Binocular Rivalry.

    Directory of Open Access Journals (Sweden)

    Ce Mo

    Full Text Available Although human preference for beauty is common and compelling in daily life, it remains unknown whether such preference is essentially subserved by social cognitive demands or natural tendency towards beauty encoded in the human mind intrinsically. Here we demonstrate experimentally that humans automatically exhibit preference for visual and moral beauty without explicit cognitive efforts. Using a binocular rivalry paradigm, we identified enhanced gender-independent perceptual dominance for physically attractive persons, and the results suggested universal preference for visual beauty based on perceivable forms. Moreover, we also identified perceptual dominance enhancement for characters associated with virtuous descriptions after controlling for facial attractiveness and vigilance-related attention effects, which suggested a similar implicit preference for moral beauty conveyed in prosocial behaviours. Our findings show that behavioural preference for beauty is driven by an inherent natural tendency towards beauty in humans rather than explicit social cognitive processes.

  19. Natural Tendency towards Beauty in Humans: Evidence from Binocular Rivalry

    Science.gov (United States)

    Mo, Lei

    2016-01-01

    Although human preference for beauty is common and compelling in daily life, it remains unknown whether such preference is essentially subserved by social cognitive demands or natural tendency towards beauty encoded in the human mind intrinsically. Here we demonstrate experimentally that humans automatically exhibit preference for visual and moral beauty without explicit cognitive efforts. Using a binocular rivalry paradigm, we identified enhanced gender-independent perceptual dominance for physically attractive persons, and the results suggested universal preference for visual beauty based on perceivable forms. Moreover, we also identified perceptual dominance enhancement for characters associated with virtuous descriptions after controlling for facial attractiveness and vigilance-related attention effects, which suggested a similar implicit preference for moral beauty conveyed in prosocial behaviours. Our findings show that behavioural preference for beauty is driven by an inherent natural tendency towards beauty in humans rather than explicit social cognitive processes. PMID:26930202

  20. El ojo hermoso The beautiful eye

    Directory of Open Access Journals (Sweden)

    O. M. Ramírez

    2007-06-01

    Full Text Available Como cirujanos estéticos siempre nos esforzamos por alcanzar resultados hermosos que sean agradables a los sentidos. Esto es particularmente cierto en el terreno del rejuvenecimiento periorbitario. Según la estadística de la Sociedad Americana de Cirujanos Plásticos la blefaroplastia estética es uno de los procedimientos mas frecuentes y su frecuencia va en aumento tanto en hombres como en mujeres. El rejuvenecimiento periorbitario adecuado debería restaurar la percepción interior del paciente respecto a belleza y juventud de sus ojos, así como proporcionar un aspecto externo que sea "estético" o agradable a los sentidos. Para lograr este objetivo, se requiere una comprensión de la estética facial, tanto en términos subjetivos como objetivos. Los investigadores han demostrado que la percepción del atractivo o la belleza en la cara de un individuo es relativamente constante entre observadores independientes, desafiando el dicho popular de que "la belleza está en el ojo del espectador." Presentamos una actualización del tema y una amplia iconografía. La información recogida de la literatura y de años experiencia clínica debería permitir al lector desarrollar una mayor sensibilidad estética, para obtener resultados óptimos en el rejuvenecimiento periorbitario.As aesthetic surgeons we are always striving to achieve beautiful results that are pleasurable to the senses. This is particularly certain in the land of the periorbital rejuvenation. According to the statistics of the American Society of Plastic Surgeons, aesthetic blepharoplasty is one of the procedures most commonly performed and goes in increase its so much frequency in men as in women. Successful periorbital rejuvenation should restore the patient"s inner sense of beauty and youthfulness as well as provide an outward appearance that is ‘aesthetic" or pleasurable to the senses. To accomplish this lofty goal, the aesthetic surgeon must strive to create "the beautiful

  1. ICTR-PHE Public Talk | Physics is beautiful and useful by Ugo Amaldi | 11 February

    CERN Multimedia

    2014-01-01

    In the framework of the International Conference on Translational Research in Radiation Oncology – Physics for Health in Europe (ICTR-PHE, see here), which will take place at the Geneva International Conference Centre from 10 to 14 February 2014, the public is invited to attend an exceptional talk:   Physics is beautiful and useful by Ugo Amaldi Tuesday 11 February 2014, 6.30 p.m. Geneva International Conference Centre 17, rue de Varembé, Geneva *The talk will be in English with simultaneous translation into French* Abstract: The year 2014 marks the 60th anniversary of CERN and of the first cancer treatment with protons done at Berkeley. This is no coincidence: indeed, the beauty of particle physics has always gone hand in hand with useful applications. These “useful” activities follow from the technical developments in particle accelerators and radiation detectors that have brought about the discoveries of neutral currents (1973), of its mediator the...

  2. Non-leptonic decays of beauty decays

    CERN Document Server

    Bigi, Ikaros I; Shifman, M; Uraltsev, N; Vainshtein, A I

    1994-01-01

    "Anyone who keeps the ability to see beauty never grows old" (Franz Kafka). In the last few years considerable progress has been achieved in our understanding of the decays of heavy flavour hadrons. One can now calculate inclusive transition rates in QCD proper through an expansion in inverse powers of the heavy flavour quark mass without recourse to phenomenological assumptions. The non-perturbative contributions are treated systematically in this way; they are found to produce corrections of order a few percent in beauty decays, i.e. typically somewhat smaller than the perturbative corrections. One finds, among other things: (a) The lifetime of $B^-$ mesons is predicted to be longer than that of $B^0$ mesons by several percent. (b) The QCD prediction for the semileptonic branching ratio of $B$ mesons appears to exceed present experimental values.

  3. Charm and beauty production at RHIC

    Energy Technology Data Exchange (ETDEWEB)

    Kabana, Sonia [Laboratoire de Physique Subatomique et des Technologies Associees (SUBATECH), Ecole des Mines, 4 rue Alfred Kastler, 44307 Nantes (France)

    2011-01-15

    We review selected highlights on charm and beauty production at RHIC from p+p, d+Au and A+A collisions at {radical}(s{sub NN})=200GeV, and compare them to model calculations. We focus on two particular issues, jet quenching and quarkonia. Anomalous energy loss (jet quenching) of quarks passing through the dense and hot matter built in heavy ion collisions is one of the outstanding discoveries made at RHIC. This phenomenon allows for an estimate of the initial gluon density. Furthermore, color screening of hidden charm and beauty states is a key signature of the QCD phase transition, allowing an estimate of the initial temperature. We present results on the flavour dependence of jet quenching. Heavy flavour production in A+A as compared to p+p collisions will be discussed for open and hidden charm.

  4. China's Most Beautiful Books

    Institute of Scientific and Technical Information of China (English)

    WuLiang

    2005-01-01

    “China's Most Beautiful Books 2004”, an annual national award for books' graphic design, came out in Shanghai in January, 2005. Twenty-four publications won the titles and were recommended to participate in “The Most Beautiful Books of the World 2005” competition which will be held in Leibzig, Germany. The award winners included both best sellers with simplistic design such as “Us Three” and “Niu Niu: A Father's Notes”, and thread-bound traditional books such as “Ma De's Painting Album”, “Nanmu Carvings in West of Hunan Province”, “Watch the Three Gorges” and “Culture of Southeast China: Key Words”。

  5. ''Beauty of Wholeness and Beauty of Partiality.'' New Terms Defining the Concept of Beauty in Architecture in Terms of Sustainability and Computer Aided Design

    Science.gov (United States)

    Farid, Ayman A.; Zaghloul, Weaam M.; Dewidar, Khaled M.

    2014-01-01

    The great shift in sustainability and computer aided design in the field of architecture caused a remarkable change in the architecture philosophy, new aspects of beauty and aesthetic values are being introduced, and traditional definitions for beauty cannot fully cover this aspects, which causes a gap between; new architecture works criticism and…

  6. The neural correlates of beauty comparison

    OpenAIRE

    Kedia, Gayannée; Mussweiler, Thomas; Mullins, Paul; Linden, David E. J.

    2013-01-01

    Beauty is in the eye of the beholder. How attractive someone is perceived to be depends on the individual or cultural standards to which this person is compared. But although comparisons play a central role in the way people judge the appearance of others, the brain processes underlying attractiveness comparisons remain unknown. In the present experiment, we tested the hypothesis that attractiveness comparisons rely on the same cognitive and neural mechanisms as comparisons of simple nonsocia...

  7. Sleeping Beauty: Kleine–Levin Syndrome

    OpenAIRE

    Mudgal, Soumiya; Jiloha, R. C.; Kandpal, Manish; Das, Aparna,

    2014-01-01

    Kleine–Levin syndrome (KLS) alias sleeping beauty syndrome, is a rare sleep disorder. Clinically presenting as episodes of hypersomnolence, behavioral and cognitive disturbances, hyperphagia and hypersexuality. KLS may have an idiopathic onset or may be precipitated by neurological event or infection. Until date, no definite underlying cause is established and neither there are any definitive management guidelines. It remains a diagnosis of exclusion after other psychiatric and neurological c...

  8. Beautiful seasons of Pan’an

    Institute of Scientific and Technical Information of China (English)

    季陈熙; 陈妙芳

    2015-01-01

    I.m from Pan an,It s a small town of Zhejiang.Do you know?It s the most beautiful palce in my heart.Panan is a bes place to live.In Pan an,The water is clean,the trees are green,the air is very fresh.In an increasingly harsh environment,PM2.5 is also rampant worldwide,Pan an is getting more and more popula

  9. The 2012 Interferometric Imaging Beauty Contest

    OpenAIRE

    Baron, Fabien; Cotton, William D.; Lawson, Peter R.; Ridgway, Steve T.; Aarnio, Alicia; Monnier, John D.; Hofmann, Karl-Heinz; Schertl, Dieter; Weigelt, Gerd; Thiébaut, Eric; Soulez, Férréol; Mary, David; Millour, Florentin; Vannier, Martin; Young, John

    2012-01-01

    We present the results of the fifth Interferometric Imaging Beauty Contest. The contest consists in blind imaging of test data sets derived from model sources and distributed in the OIFITS format. Two scenarios of imaging with CHARA/MIRC-6T were offered for reconstruction: imaging a T Tauri disc and imaging a spotted red supergiant. There were eight different teams competing this time: Monnier with the software package MACIM; Hofmann, Schertl and Weigelt with IRS; Thi\\'ebaut and Soulez with M...

  10. Hidden Beauty in Twisted Viking Neck Rings

    OpenAIRE

    Olsen, Kasper; Bohr, Jakob

    2010-01-01

    Many hoards found in Ireland, Scotland, Orkney Islands, and Scandinavia demonstrate the vikings ability to fabricate beautiful arm and neck rings of twisted silver and gold rods. Characteristic for such rings is the uniform appearance of the twisted pattern along the length of the arm ring, as well as from one arm ring to another, also when found at distant geographical locations. How can the appearance of the twisted wires be so perfectly repetitive? We demonstrate that the answer is that th...

  11. BEAUTY IN THE AGE OF MARKETING

    OpenAIRE

    Bingqing Yin; Susie Pryor

    2012-01-01

    Research has repeatedly demonstrated that beauty is positively related to a number of important outcomes including social and personal power, self-esteem, and preferential treatment from others (Bloch and Richins, 1992; cf. Adams, 1977; Goldman and Lewis, 1977). Moreover, studies consistently suggest that the use of physically attractive models results in positive effects (Berscheid and Walster, 1974; Bower, 2011; Buunk and Dijkstra, 2011; Landy and Sigall, 1974). Accordingly, advertisers uti...

  12. Glumpy : Fast, scalable and beautiful scientific visualization

    OpenAIRE

    Rougier, Nicolas P.

    2015-01-01

    Glumpy is a python library for scientific visualization that is both fast, scalable and beautiful. Glumpy offers an intuitive interface between numpy and modern OpenGL. Numpy arrays are tracked automatically such that any change on the CPU is reflected automatically on the GPU, making the integration seamless. glumpy provides more than 100 examples showing how to achieve this or that visualization, such as antialiasing, text rendering, isolines computation, image filtering, cartographic proje...

  13. Molecular profiling of tumour budding implicates TGFβ-mediated epithelial–mesenchymal transition as a therapeutic target in oral squamous cell carcinoma

    DEFF Research Database (Denmark)

    Jensen, David Hebbelstrup; Dabelsteen, Erik; Specht, Lena;

    2015-01-01

    Although tumour budding is an adverse prognostic factor for many cancer types, the molecular mechanisms governing this phenomenon are incompletely understood. Therefore, understanding the molecular basis of tumour budding may provide new therapeutic and diagnostic options. We employ digital image...

  14. Lifetimes of charm and beauty hadrons

    Science.gov (United States)

    Bellini, G.; Bigi, I. I.; Dornan, P. J.

    1997-10-01

    Major breakthroughs have been achieved in the determination of the lifetimes of charm and beauty hadrons. Much larger data samples than previously have become available and new experimental devices and techniques have been developed and employed. The lifetimes of all weakly decaying singly charmed hadrons have been measured, some with an accuracy of a few percent. The difference in the shortest lifetime - τ(Ω c) - and the longest one - τ( D+) - is given by a factor of close to ten. The experimental status of beauty lifetimes, while less complete, has still reached a new level of quality and is now better than 5% for the commoner states. New theoretical tools, based mainly on heavy quark expansions, have been developed; they incorporate as well as transcend earlier phenomenological descriptions. The observed pattern in the charm lifetime ratios is reproduced in a semi-quantitative manner as well as could be expected; as far as the beauty lifetime ratios are concerned some problems may well be emerging. The maturity level achieved in the measurements bodes quite well for future challenges where reliable and efficient tracking of the decay vertices will be crucial.

  15. Impact of Beauty Creations Among College Going Girls

    OpenAIRE

    Mr. Shinto Sebastian

    2011-01-01

    This article tries to attempt to explain the emerging beauty consciousness of present world. This would be raging from the different issues with varied perspectives. This includes media discourse, marketing strategies, psychological pluralism etc… it is an attempt to find out the current scenario of modern world which attempts dictates terms for beauty and how it is being carried out by the younger generation especially college going girls. The attempt dealt with the success and beauty as wel...

  16. Role of social media in beauty care marketing communication

    OpenAIRE

    Brichová, Eva

    2015-01-01

    The master's thesis elaborates on the width of roles social media can play for beauty businesses. Major social channels predominantly used in beauty care marketing are identified and investigated, specifically in terms of their statistical importance, role within the social media strategy and potential for use in this particular industry. The practical part of the thesis deals with a case study regarding social media strategy in a specific area of the beauty care business -- professional hair...

  17. The Most Beautiful Heart%最美丽的心

    Institute of Scientific and Technical Information of China (English)

    章纯

    2010-01-01

    @@ One day a young man was standing in the middle of the town proclaiming that he had the most beautiful heart in the whole valley.A large crowd gathered and they all admired his heart for it was perfect.There was not a mark or a flaw in it.Yes,they all agreed it truly was the most beautiful heart they had ever seen.The young man was very proud and boasted1 more loudly about his beautiful heart.

  18. The prostitute's allure: Examining returns to beauty, productivity and discrimination

    OpenAIRE

    Arunachalam, Raj; Shah, Manisha

    2010-01-01

    We estimate the earnings premium for beauty in an occupation where returns to physical attractiveness are likely to be important: commercial sex work. In the commercial sex market, perhaps more so than any other sector in the labor market, the beauty premium should be at the extreme due to the intimate interpersonal relationships required with clients. Therefore, the commercial sex sector provides the cleanest test for whether the beauty premium is driven solely by productivity. Somewhat surp...

  19. Charm and beauty decays in the ALEPH experiment

    International Nuclear Information System (INIS)

    Results of the ALEPH experiment at LEP are presented on charm and beauty decays, from data taken in 1990 and 1991. Several exclusive channels of charm and beauty mesons are seen. Evidence is given for the production of beauty baryons from correlations between a high Pt lepton and a Λ0 or a Λc baryon. Finally, first evidence is given for the production of the strange B meson, from Ds-lepton correlations. (author) 7 refs., 7 figs

  20. Beauty production at HERA using the HI detector

    Energy Technology Data Exchange (ETDEWEB)

    Thompson, P [School of Physics, University of Birmingham, BIRMINGHAM B15 2TT (United Kingdom)], E-mail: pdt@hep.ph.bham.ac.uk

    2008-05-15

    Recent measurements on beauty production at HERA using the HI experiment are presented. The cross section for beauty dijets in photoproduction and the contribution of the inclusive beauty cross section in deep-inelastic scattering (DIS) are shown. The results are based on a method using the impact parameter, in the transverse plane, of tracks to the primary vertex, as measured by the HI vertex detector. The measurements are compared with the predictions of next-to-leading order (NLO) QCD.

  1. A hyperactive sleeping beauty transposase enhances transgenesis in zebrafish embryos

    OpenAIRE

    Lardelli Michael; Newman Morgan

    2010-01-01

    Abstract Background Transposons are useful molecular tools for transgenesis. The 'sleeping beauty' transposon is a synthetic member of the Tc1/mariner transposon family. Davidson et al. (2003) previously described a vector for zebrafish transgenesis consisting of the inverted repeats of 'sleeping beauty' flanking the gene to be transposed. Subsequently, there have been attempts to enhance the transpositional activity of 'sleeping beauty' by increasing the activity of its transposase. Recently...

  2. Beauty in abstract paintings: perceptual contrast and statistical properties

    Science.gov (United States)

    Mallon, Birgit; Redies, Christoph; Hayn-Leichsenring, Gregor U.

    2014-01-01

    In this study, we combined the behavioral and objective approach in the field of empirical aesthetics. First, we studied the perception of beauty by investigating shifts in evaluation on perceived beauty of abstract artworks (Experiment 1). Because the participants showed heterogeneous individual preferences for the paintings, we divided them into seven clusters for the test. The experiment revealed a clear pattern of perceptual contrast. The perceived beauty of abstract paintings increased after exposure to paintings that were rated as less beautiful, and it decreased after exposure to paintings that were rated as more beautiful. Next, we searched for correlations of beauty ratings and perceptual contrast with statistical properties of abstract artworks (Experiment 2). The participants showed significant preferences for particular image properties. These preferences differed between the clusters of participants. Strikingly, next to color measures like hue, saturation, value and lightness, the recently described Pyramid of Histograms of Orientation Gradients (PHOG) self-similarity value seems to be a predictor for aesthetic appreciation of abstract artworks. We speculate that the shift in evaluation in Experiment 1 was, at least in part, based on low-level adaptation to some of the statistical image properties analyzed in Experiment 2. In conclusion, our findings demonstrate that the perception of beauty in abstract artworks is altered after exposure to beautiful or non-beautiful images and correlates with particular image properties, especially color measures and self-similarity. PMID:24711791

  3. Beauty in abstract paintings: Perceptual contrast and statistical properties

    Directory of Open Access Journals (Sweden)

    Birgit eMallon

    2014-03-01

    Full Text Available In this study, we combined the behavioral and objective approach in the field of empirical aesthetics. First, we studied the perception of beauty by investigating shifts in evaluation on perceived beauty of abstract artworks (Experiment 1. Because the participants showed heterogeneous individual preferences for the paintings, we divided them into seven clusters for the test. The experiment revealed a clear pattern of perceptual contrast. The perceived beauty of abstract paintings increased after exposure to paintings that were rated as less beautiful, and it decreased after exposure to paintings that were rated as more beautiful. Next, we searched for correlations of beauty ratings and perceptual contrast with statistical properties of abstract artworks (Experiment 2. The participants showed significant preferences for certain image properties. These preferences differed between the clusters of participants. Strikingly, next to color measures like hue, saturation, value and lightness, the recently described PHOG self-similarity value seems to be a predictor for aesthetic appreciation of abstract artworks. We speculate that the shift in evaluation in Experiment 1 was, at least in part, based on low-level adaptation to some of the statistical image properties analyzed in Experiment 2. In conclusion, our findings demonstrate that the perception of beauty in abstract artworks is altered after exposure to beautiful or non-beautiful images and correlates with particular image properties, especially color measures and self-similarity.

  4. Beautiful, but also potentially invasive

    Directory of Open Access Journals (Sweden)

    Lipták Boris

    2015-03-01

    Full Text Available Introduction of non-indigenous exotic species to new areas, where they may establish viable populations and become invasive, is a considerable problem in the protection of nature worldwide, as these species may alter the indigenous species population structure and potentially even decrease the biodiversity. The European fauna underwent through major negative changes on the continent and nowadays, it experiences another new treat, represented by the expanding aquarium pet trade, and with it, associated species (and disease introductions. Exotic freshwater crustaceans are one of the taxa widely incorporated in the business, counting a remarkable number of species. Recent records of the exotic marbled crayfish or Marmorkrebs (Procambarus fallax f. virginalis in German in open ecosystems in Slovakia pointed to human-mediated introductions associated with aquarium pet trade in the country. In this regard, a study of the aquarium pet trade both in expositions and shops and online was assessed. Several crustacean taxa are available both in pet trade exhibitions and online through the Internet. Altogether 26 different species were identified in the aquarium trade in Slovakia. These are Procambarus fallax f. virginalis, P. clarkii, P. alleni, Cherax quadricarinatus, C. destructor, C. holthuisi, C. peknyi, Cambarellus patzcuarensis and C. diminutus occurring in the aquarium pet trade in Slovakia (n = 9. Procambarus fallax f. virginalis, P. clarkii and C. patzuarensis are the most common in this regard. There is also a quantity of other related taxa in the aquarium pet trade in Slovakia, mainly Caridina spp. (n = 5, Neocaridina spp. (n = 4, Atyopsis moluccensis, Atya gabonensis, Arachnochium kulsiense and several taxa of exotic crabs (n = 5 belonging to three different genera (Cardiosoma, Geosesarma and Gecarinus present. Neocaridina davidi is identified as the most frequent in this regard. As some of the species can become established and form viable

  5. Beautiful Architecture Leading Thinkers Reveal The Hidden Beauty In Software Design

    CERN Document Server

    Spinellis, Diomidis

    2009-01-01

    What are the ingredients of robust, elegant, flexible, and maintainable software architecture? Beautiful Architecture answers this question through a collection of intriguing essays from more than a dozen of today's leading software designers and architects. In each essay, contributors present a notable software architecture, and analyze what makes it innovative and ideal for its purpose.

  6. 抽脂美容酿纠纷依法调解显公正--医疗纠纷人民调解案例分析%Disputes Brewed by Liposuction Beauty, Fair Resolution through Mediation according to Law--People's Mediation Cases of Medical Disputes

    Institute of Scientific and Technical Information of China (English)

    雷红力

    2015-01-01

    医疗纠纷人民调解制度在全国各地逐渐展开,发挥了积极的作用。在调解过程中,需要运用到一系列的方法和技巧;就此,本文通过对一例抽脂美容手术的医疗纠纷的分析,详细讲述了根据现场实际情况巧妙使用一系列调解方法和技巧的过程,具有较好的实践借鉴和指引价值。%People's mediation system for medical disputes gradually spread all over the country, and it has played a positive role. We need apply a series of methods and techniques to the process of mediation. Therefore, taking one medical dispute of liposuction plastic surgery as an example, the author described in detail the media-tion process of ingenious use of a series of methods and techniques according to the actual situation, which had a good practical value for reference and guidance.

  7. Beauty physics at e+ e- colliders

    International Nuclear Information System (INIS)

    Beauty physics to be performed in the next decade at the resonances Y(4S) and Z0 are compared. Large similarities are found in the physics program and the reconstruction techniques of Z0 and asymmetric Y(4S) colliders. The physics potential of the latter is found to be superior at equal luminosity to a symmetric machine, provided a large enough boost (≥ 5). Z0 machines will probably be the main source of the rich BS0 physics during that period

  8. Beautiful and other heavy baryons revisited

    Energy Technology Data Exchange (ETDEWEB)

    Martin, A.; Richard, J.M.

    1987-02-19

    We discuss the mass range for the beautiful baryons ..lambda../sub b/, ..sigma../sub b/ and ..sigma../sub b//sup */ allowed by rigorous inequalities which are derived in the framework of potential models but have probably a broader domain of validity. We obtain at the same time lower bounds on the masses of other baryons. We also compare the numerical prediction of several explicit models. There are convergent indications towards a mass of about 5.6 GeV for the ..lambda../sub b/.

  9. Safe is beautiful{exclamation_point}

    Energy Technology Data Exchange (ETDEWEB)

    Codee, H.D.K. [COVRA N.V., Vlissingen (Netherlands)]. E-mail: hccovra@zeelandnet.nl

    2006-07-01

    In the Netherlands long-term (100y) storage of all waste types in above ground, engineered structures, is a basic element of the waste management system. This is not a 'wait-and-see' solution, because at the same time provisions are taken for the final disposal. Facilities for treatment and storage of low, medium and high-level waste are in operation. The facility for high-level waste was commissioned in 2003. This facility is not only a technical building but also a work of art. We show that we are proud on our work. SAFE = BEAUTIFUL{exclamation_point} (author)

  10. A Beautiful Blonde: a Nash coordination game

    OpenAIRE

    Anderson, Simon P.; Maxim Engers

    2002-01-01

    In a memorable scene from the …lm ”A Beautiful Mind,” John Nash explains to his friends how to direct their attentions to women in a bar. Game theorists who have seen the …lm point out that the proposed solution is not a Nash equilibrium. Here we determine the Nash equilibria to the attention game. The symmetric mixed strategy equilibrium has resembles a common property resource problem. It has perverse comparative static properties that are not borne out by experimental data. Finally, we dis...

  11. Does it pay to be beautiful?

    OpenAIRE

    SIERMINSKA Eva

    2015-01-01

    It is a well-established view amongst economists that good-looking people have a better chance of employment and can earn more than those who are less physically attractive. A “beauty premium” is particularly apparent in jobs where there is a productivity gain associated with good looks, though this is different for women and men, and varies across countries. People also sort into occupations according to the relative returns to their physical characteristics; good-looking people take jobs wh...

  12. Haiti. Beauty parlours and health promoters.

    Science.gov (United States)

    Hughes, H

    1990-04-01

    In the poor neighborhoods of the capital city of Port au Prince Haiti are 100s of brightly painted beauty parlors, displaying signs like "Femme Moderne, studio de beaute." They are popular and cheap; between 70 and 80% of the population use them. In the south of the city, a team of health promotion volunteers are turning some 64 beauty parlors into AIDS education and condom distribution centers with the help and cooperation of the owners. The majority of these beauty parlors are owned and run by women who cannot find work elsewhere, including many immigrants from the Dominican Republic. Some proprietors work as prostitutes in the evenings because they cannot survive on the earnings of the parlors. These proprietors are now becoming AIDS educators-- talking to customers, handing out leaflets and distributing free condoms. The team of young volunteers responsible for this education program belong to the Center for Haitian Social Services (CHASS); a nonprofit, voluntary organization set up in 1987 as a community response to the lack of government health and social services. A CHASS volunteer explains: "The beauty parlors were chosen as a focal point for reaching the population. To start with, 1 box of condoms was distributed every week, not the owners are distributing 3 or 4 boxes. We encourage them to keep a record of numbers taken, client's age, sex, marital status and so on." The majority of volunteer health promoters are ex-students who have given up their studies because of lack of funds. Many cannot find jobs, and they are encouraged to develop skills in their volunteer work which could help them find employment in the future. The team of volunteers meets every Saturday to discuss the program and training needs that arise. "At first the focus of our training was on AIDS, but now we need more information about other related issues." The most urgent need is to find out what local people's thoughts and understandings are about the disease. CHASS has designed a

  13. The Aesthetics of Race versus the Beauty of Humanity.

    Science.gov (United States)

    Pontynen, Arthur

    2002-01-01

    Recommends rejecting race (an aesthetic concept) and returning to the apprehension, appreciation, and realization of beauty. Discusses aesthetics and racism, racism and postmodernism, and postmodernism and despair. Explains that recognition of the continuum from aesthetics to beauty would mark the demise of aesthetics and the rise of a new and…

  14. Transposons for cancer gene discovery: Sleeping Beauty and beyond

    OpenAIRE

    Collier, Lara S.; Largaespada, David A

    2007-01-01

    The use of Sleeping Beauty transposons as somatic mutagens to discover cancer genes in hematopoietic tumors and sarcomas has been documented. Here, we discuss the future of Sleeping Beauty for cancer genetic studies and the potential use of additional transposable elements for somatic mutagenesis.

  15. Charm and beauty measurements at Fermilab fixed target

    International Nuclear Information System (INIS)

    Eighteen months after a successful run of the Fermilab fixed target program, interesting results from several experiments are available. This is the first time that more than one Fermilab fixed target experiment has reported the observation of beauty mesons. In this paper the author reviews recent results from charm and beauty fixed target experiments at Fermilab

  16. Charm and beauty measurements at Fermilab fixed target

    International Nuclear Information System (INIS)

    Eighteen months after a successful run of the Fermilab fixed target program, interesting results from several experiments are available. This is the first time that more than one Fermilab fixed target experiment has reported the observation of beauty mesons. In this paper we review recent results from charm and beauty fixed target experiments at Fermilab

  17. Beauty: A Concept with Practical Implications for Teacher Researchers

    Science.gov (United States)

    Winston, Joe

    2011-01-01

    Hillman's (2001) simple affirmation that "an idea of beauty is useful, functional, practical" is one this article attempts to pursue with teacher researchers in mind, based on the belief that to move from the "re"pression of beauty to its "ex"pression--or, at the very least, to its articulation--will enlighten rather than distract individuals. The…

  18. On the beauty of nature, paintings and music

    Directory of Open Access Journals (Sweden)

    Ekin Çoraklı

    2014-07-01

    Full Text Available There is a wide range of things that are classified by humans in terms of their level of beauty. The word ‘beautiful’ is used to define some of the natural entities living and nonliving, unnatural objects or ideas produced by humans, and the works of art, which are unique products of human hand and brain. Beauty, as a concept awakening a common feeling of pleasure, may mean something deeper than we are aware of. This meaning is perhaps hidden in its deeper aspects, which we have to give effort to analyze. Hence, within context of this paper, common and specific properties of the beauty of nature, paintings and music will be discussed. In addition, the stages of the perception of the beauty of all kinds will be called into question, and an account about the process of the judgment of beauty will be suggested. The specific types of beauty analyzed through the paper are limited with the beauty of nature, paintings and absolute music (music without words, following an opening remark about the beauty in general.

  19. Collider phenomenology of light strange-beauty squarks

    International Nuclear Information System (INIS)

    We summarize a study on the production, decay, and detection of the strange-beauty squark as light as 200 GeV at hadronic and e+e- colliders. It was motivated by nearly maximal mixing between strange and beauty squarks. (author)

  20. WORLDVIEW BEAUTY IN THE CONTEXT OF PHILOSOPHICAL ANTHROPOLOGY AS METAANTHROPOLOGY

    OpenAIRE

    Крилова, Світлана Анатоліївна

    2015-01-01

    The beauty of world outlook is investigated in the context of philosophical outlook. Everyday, personal and philosophical outlooks are compared with mythological, religious and scientific ones and with the concepts of “irony” and “pathos”. The problem of sense of life is analyzed as a fundamental criterion of the beauty of world outlook.

  1. Gender Differences in the Motivational Processing of Facial Beauty

    Science.gov (United States)

    Levy, Boaz; Ariely, Dan; Mazar, Nina; Chi, Won; Lukas, Scott; Elman, Igor

    2008-01-01

    Gender may be involved in the motivational processing of facial beauty. This study applied a behavioral probe, known to activate brain motivational regions, to healthy heterosexual subjects. Matched samples of men and women were administered two tasks: (a) key pressing to change the viewing time of average or beautiful female or male facial…

  2. Could carnosine suppress zinc-mediated proteasome inhibition and neurodegeneration? Therapeutic potential of a non-toxic but non-patentable dipeptide.

    Science.gov (United States)

    Hipkiss, Alan R

    2005-01-01

    Ageing and neurodegenerative conditions are often associated with proteasome dysfunction, possibly mediated by zinc and/or copper ions. Studies have shown that (i) the olfactory lobe is normally enriched in carnosine and zinc, (ii) carnosine can suppress copper and zinc toxicity in olfactory neurones, (iii) olfactory dysfunction is often associated with neurodegenerative conditions and (iv) elevated levels of zinc are found in brains of Alzheimer's patients. It is suggested that nasal administration of carnosine should be explored as a possible way of suppressing zinc/copper-mediated proteasome inhibition and consequent neurodegeneration. PMID:16034682

  3. Beauty production at HERA using the ZEUS experiment

    Energy Technology Data Exchange (ETDEWEB)

    Yaguees, A [Humboldt University in Berlin, Newtonstrasse 15, 12489 Berlin (Germany)], E-mail: yagues@mail.desy.de

    2008-05-15

    Beauty quark production in ep collisions is being studied with the ZEUS detector at HERA. The latest measurements of beauty production in deep inelastic scattering and photoproduction regime are presented. The first measurement exploits the potential of the ZEUS microvertex detector to identify beauty in photoproduction dijet events with a muon in the final state. The second is based on statistical methods to determine the fraction of beauty in photoproduction dijet events with an electron in the final state. Finally, the first measurement by ZEUS of the beauty contribution to the proton structure function, F{sub 2}bb, in deep inelastic scattering is presented. The three measurements are compared with QCD predictions as well as with previous results. All the results presented here are preliminary.

  4. An exploratory content analysis of a Saudi women's beauty products' discussion forum

    OpenAIRE

    Al-Haidari, N; Coughlan, J.

    2015-01-01

    Online communities are an important source of electronic word-of-mouth (e-WOM). However, few studies have examined the use of such messages within the Middle Eastern context. This study focuses on Saudi women as members of an online beauty forum. Previous work suggested a mediating effect of gender, with women being more likely to trust word-of-mouth and follow it up with a purchase. A conceptual model with a theoretical underpinning from existing contributions in literature provides the basi...

  5. Online Responses to a Multilingual Super Bowl Ad: Is "America the Beautiful" by Any Other Language Still America, the Beautiful?

    Science.gov (United States)

    Hoffman, Brooke Y.

    2016-01-01

    On 2 February 2014, an advertisement entitled "It's Beautiful" debuted during Super Bowl XLVIII, which was watched by 111.5 million people in the USA. The Coca-Cola advertisement portrayed people of various ethnicities and was accompanied by "America the Beautiful" sung in nine languages. Using critical discourse analysis, I…

  6. The neural correlates of beauty comparison.

    Science.gov (United States)

    Kedia, Gayannée; Mussweiler, Thomas; Mullins, Paul; Linden, David E J

    2014-05-01

    Beauty is in the eye of the beholder. How attractive someone is perceived to be depends on the individual or cultural standards to which this person is compared. But although comparisons play a central role in the way people judge the appearance of others, the brain processes underlying attractiveness comparisons remain unknown. In the present experiment, we tested the hypothesis that attractiveness comparisons rely on the same cognitive and neural mechanisms as comparisons of simple nonsocial magnitudes such as size. We recorded brain activity with functional magnetic resonance imaging (fMRI) while participants compared the beauty or height of two women or two dogs. Our data support the hypothesis of a common process underlying these different types of comparisons. First, we demonstrate that the distance effect characteristic of nonsocial comparisons also holds for attractiveness comparisons. Behavioral results indicated, for all our comparisons, longer response times for near than far distances. Second, the neural correlates of these distance effects overlapped in a frontoparietal network known for its involvement in processing simple nonsocial quantities. These results provide evidence for overlapping processes in the comparison of physical attractiveness and nonsocial magnitudes. PMID:23508477

  7. Structural Determinants of Sleeping Beauty Transposase Activity.

    Science.gov (United States)

    Abrusán, György; Yant, Stephen R; Szilágyi, András; Marsh, Joseph A; Mátés, Lajos; Izsvák, Zsuzsanna; Barabás, Orsolya; Ivics, Zoltán

    2016-08-01

    Transposases are important tools in genome engineering, and there is considerable interest in engineering more efficient ones. Here, we seek to understand the factors determining their activity using the Sleeping Beauty transposase. Recent work suggests that protein coevolutionary information can be used to classify groups of physically connected, coevolving residues into elements called "sectors", which have proven useful for understanding the folding, allosteric interactions, and enzymatic activity of proteins. Using extensive mutagenesis data, protein modeling and analysis of folding energies, we show that (i) The Sleeping Beauty transposase contains two sectors, which span across conserved domains, and are enriched in DNA-binding residues, indicating that the DNA binding and endonuclease functions of the transposase coevolve; (ii) Sector residues are highly sensitive to mutations, and most mutations of these residues strongly reduce transposition rate; (iii) Mutations with a strong effect on free energy of folding in the DDE domain of the transposase significantly reduce transposition rate. (iv) Mutations that influence DNA and protein-protein interactions generally reduce transposition rate, although most hyperactive mutants are also located on the protein surface, including residues with protein-protein interactions. This suggests that hyperactivity results from the modification of protein interactions, rather than the stabilization of protein fold. PMID:27401040

  8. The beauty of the physical world

    CERN Multimedia

    CERN Bulletin

    2010-01-01

    Graham Farmelo, author and former particle physicist, visited CERN on 25 March. To the CERNois gathered in the Main Auditorium, he talked about his new book The Strangest Man, a biography of Paul Dirac. Dirac was obsessed by the importance of mathematical beauty in fundamental physics, a belief that was “almost a religion” to him. Farmelo himself has no doubts: among all of the natural phenomena the LHC may unveil, supersymmetry is the most beautiful.   Talking about the life of a physicist to draw the attention of the public to the science: that was the idea behind Graham Farmelo decision to write a biography of Paul Dirac. The book won the 2009 Costa Biography Award. “I chose Paul Dirac because he was the first truly modern theoretical physicist but he is virtually unknown to the public”, explains Graham Farmelo. “Dirac had a fascinating life. He was not born in a wealthy or a particularly brilliant family but he ended up conceiving in his head ...

  9. The end of Sleeping Beauty's nightmare

    CERN Document Server

    Groisman, Berry

    2008-01-01

    The way a rational agent changes her belief in certain propositions/hypotheses in the light of new evidence lies at the heart of Bayesian inference. The basic natural assumption, as summarized in van Fraassen's Reflection Principle ([1984]), would be that in the absence of new evidence the belief should not change. Yet, there are examples that are claimed to violate this assumption. The apparent paradox presented by such examples, if not settled, would demonstrate the inconsistency and/or incompleteness of the Bayesian approach and without eliminating this inconsistency, the approach cannot be regarded as scientific. The Sleeping Beauty Problem is just such an example. The existing attempts to solve the problem fall into three categories. The first two share the view that new evidence is absent, but differ about the conclusion of whether Sleeping Beauty should change her belief or not, and why. The third category is characterized by the view that, after all, new evidence (although hidden from the initial view...

  10. Charm and beauty structure of the proton

    CERN Document Server

    Brugnera, R

    2007-01-01

    This paper will review the data collected by the H1 and ZEUS Collaborations concerning the production of heavy quarks (charm and beauty) at the electron-proton collider HERA. Heavy quark production is an important testing ground for quantum chromodynamics (QCD), because QCD calculations are expected to be reliable if a hard scale is present in the process. In heavy quarks production a hard scale is provided by the quark mass. Moreover heavy quarks production can give direct access to the gluon density in the proton due to the fact that it proceeds, in QCD, almost exclusively via photon-gluon fusion, where a photon from the incoming electron interacts with a gluon in the proton giving an heavy quark-anti-quark pair. Results will be shown both for deep-inelastic scattering (DIS), where the virtuality of the exchanged boson Q**2 is large, and photo-production, where the Q**2 is equal to zero. Various experimental techniques are used in order to select charm and beauty events, ranging from the measurement of D* c...

  11. Herpes simplex virus/Sleeping Beauty vector-based embryonic gene transfer using the HSB5 mutant: loss of apparent transposition hyperactivity in vivo.

    Science.gov (United States)

    de Silva, Suresh; Mastrangelo, Michael A; Lotta, Louis T; Burris, Clark A; Izsvák, Zsuzsanna; Ivics, Zoltán; Bowers, William J

    2010-11-01

    The Sleeping Beauty (SB) transposon system has been successfully used as a gene delivery tool in nonviral and viral vector platforms. Since its initial reconstruction, a series of hyperactive mutants of SB have been generated. Questions remain as to whether the enhanced in vitro activities of these SB transposase mutants translate to the in vivo setting, and whether such increased integration efficiencies will ultimately compromise the safety profile of the transposon platform by raising the risk of genomic insertional mutagenesis. Herein, we compared the in vivo impact of a herpes simplex virus (HSV) amplicon-vectored "wild-type" SB transposase (SB10) and a "hyperactive" SB mutant (HSB5), codelivered in utero with the HSVT-βgeo transposable reporter amplicon vector to embryonic day 14.5 C57BL/6 mice. The SB10 and HSB5 transposases do not disparately affect the viability and development of injected mouse embryos. Quantitation of brain-resident βgeo expression on postnatal day 21 revealed that mice receiving HSB5 exhibited only a trending increase in transgene expression compared with the SB10-infused group, an outcome that did not mirror the marked enhancement of HSB5-mediated transposition observed in vitro. These findings indicate that in vivo application of hyperactive SB mutants, although not differentially genotoxic to the developing mouse embryo, does not necessarily provide a significant therapeutic advantage over the employment of a lesser active SB when delivered in the context of the HSV/SB amplicon platform. PMID:20507234

  12. Literary aesthetics: beauty, the brain, and Mrs. Dalloway.

    Science.gov (United States)

    Hogan, Patrick Colm

    2013-01-01

    Empirical research indicates that beauty is in part a matter of prototype approximation. Some research suggests that unanticipated pattern recognition is important as well. This essay begins by briefly outlining an account of beauty based on these factors. It goes on to consider complications. Minor complications include the partial incompatibility of these accounts and the importance of differentiating judgments of beauty from aesthetic response. More serious issues include the relative neglect of literature in neurologically-based discussions of beauty, which tend to focus on music or visual art. There is also a relative neglect of emotion, beyond the reward system. Finally, there is the almost complete absence of the sublime. After considering these problems broadly, the essay turns to Virginia Woolf's Mrs. Dalloway, examining its treatment of beauty and sublimity. The aim of this section is not merely to illuminate Woolf's novel by reference to neuroscientific research. It is equally, perhaps more fully, to expand our neuroscientifically grounded account of aesthetic response by drawing on Woolf's novel. In Mrs. Dalloway, there are gestures toward prototypes and patterns in beauty. But the key features are clearly emotional. Specifically, the emotions at issue in feelings of beauty and sublimity appear to be primarily attachment, on the one hand, and a profound sense of isolation, on the other. Woolf's novel also points us toward other features of aesthetic experience, crucially including the emotion-sharing that is a key function of the production and circulation of art. PMID:24290272

  13. Therapeutic effect of ent-kaur-16-en-19-oic acid on neutrophilic lung inflammation and sepsis is mediated by Nrf2.

    Science.gov (United States)

    Kim, Kyun Ha; Sadikot, Ruxana T; Joo, Myungsoo

    2016-06-01

    Kaurenoic acid (ent-kaur-16-en-19-oic acid: KA) is a key constituent found in the roots of Aralia continentalis Kitagawa (Araliaceae), a remedy to treat patients with inflammatory diseases in traditional Asian medicine. Since KA activates Nrf2, a key anti-inflammatory factor, at the cellular level, we explored a possible therapeutic usage of KA against neutrophilic inflammatory lung disease such as acute lung injury (ALI). Intraperitoneal (i.p.) injection of lipopolysaccharide (LPS) to C57BL/6 mice induced lung inflammation as in ALI. 2 h after i.p. LPS, intratracheal (i.t.) delivery of KA (0.3, 3, or 30 μg/kg body weight) improved lung structure and significantly suppressed neutrophil infiltrations to mouse lungs, with concomitant reduction of myeloperoxidase activity and of the expression of pro-inflammatory cytokine genes. While activating Nrf2 and expressing Nrf2-dependent genes in mouse lungs, KA did not significantly suppress neutrophil lung inflammation in Nrf2 KO mice. In a mouse model of sepsis, a major cause of ALI, single i.t. KA (3 μg/kg) 2 h after the onset of sepsis significantly decreased the mortality of mice. Together, these results suggest that KA has a therapeutic potential against inflammatory lung disease, the effect of which is associated with Nrf2 activation. PMID:27133718

  14. Assessing a peptidylic inhibitor-based therapeutic approach that simultaneously suppresses polyglutamine RNA- and protein-mediated toxicities in patient cells and Drosophila

    Directory of Open Access Journals (Sweden)

    Qian Zhang

    2016-03-01

    Full Text Available Polyglutamine (polyQ diseases represent a group of progressive neurodegenerative disorders that are caused by abnormal expansion of CAG triplet nucleotides in disease genes. Recent evidence indicates that not only mutant polyQ proteins, but also their corresponding mutant RNAs, contribute to the pathogenesis of polyQ diseases. Here, we describe the identification of a 13-amino-acid peptide, P3, which binds directly and preferentially to long-CAG RNA within the pathogenic range. When administered to cell and Drosophila disease models, as well as to patient-derived fibroblasts, P3 inhibited expanded-CAG-RNA-induced nucleolar stress and suppressed neurotoxicity. We further examined the combined therapeutic effect of P3 and polyQ-binding peptide 1 (QBP1, a well-characterized polyQ protein toxicity inhibitor, on neurodegeneration. When P3 and QBP1 were co-administered to disease models, both RNA and protein toxicities were effectively mitigated, resulting in a notable improvement of neurotoxicity suppression compared with the P3 and QBP1 single-treatment controls. Our findings indicate that targeting toxic RNAs and/or simultaneous targeting of toxic RNAs and their corresponding proteins could open up a new therapeutic strategy for treating polyQ degeneration.

  15. Alluring Faces: Beauty Standards in Japanese Society through the Ages

    OpenAIRE

    Laufey Magnúsdóttir 1991

    2015-01-01

    This thesis discusses images of beauty in Japanese society; what the Japanese see as beautiful women and how those ideals have developed and what has been attempted d to achieve, from the early Heian period up until to our days. The thesis is split into three parts; first how ideals of beauty were presented during the Heian (794-1185) era, highlighting the aristocracy; and the Edo (1600-1868) era, with courtesans and geishas in the spotlight. The second part looks at the Meiji era (1868-1912)...

  16. The Portraval of Beauty in Woman's Fashion Magazines

    OpenAIRE

    Moeran, Brian

    2009-01-01

    The primary contents of women’s fashion magazines are fashion, beauty and health. This paper sets out to explore the ways in which international fashion magazines such as Elle, Vogue and Marie Claire portray feminine beauty in textual and advertising matter and how their readers react to such portrayals. Beauty is analysed as grooming practice, and make-up as the prime symbol of the self and its many facets in social interaction. The paper looks at the different kinds of ‘fa...

  17. d-Amino Acid Substitution of Peptide-Mediated NF-κB Suppression in mdx Mice Preserves Therapeutic Benefit in Skeletal Muscle, but Causes Kidney Toxicity

    OpenAIRE

    Reay, Daniel P.; Bastacky, Sheldon I; Wack, Kathryn E; Stolz, Donna B.; Paul D Robbins; Clemens, Paula R

    2015-01-01

    In Duchenne muscular dystrophy (DMD) patients and the mdx mouse model of DMD, chronic activation of the classical nuclear factor-κB (NF-κB) pathway contributes to the pathogenesis that causes degeneration of muscle fibers, inflammation and fibrosis. Prior studies demonstrate that inhibition of inhibitor of κB kinase (IKK)-mediated NF-κB activation using l-isomer NF-κB essential modulator (NEMO)-binding domain (NBD) peptide-based approaches reduce muscle pathology in the mdx mouse. For our stu...

  18. Rare FCNC top, beauty and charm decays

    CERN Document Server

    Blake, Thomas

    2014-01-01

    Rare flavour changing neutral current (FCNC) decays of top, beauty and charm quarks can provide a powerful probe for as yet unobserved particles. Recent results on FCNC $b \\to s$, $c \\to u$ and $t$ transitions from the LHC experiments are reviewed. Particular attention is paid to the angular distribution of the $B^{0} \\to K^{*0} \\mu^{+} \\mu^{-}$ decay, where a measurement performed by LHCb shows a local discrepancy of 3.7 standard deviations with respect to the SM prediction. Using the decay $B^{+} \\to K^{+}\\pi^{-}\\pi^{+}\\gamma$, LHCb have also been able to demonstrate the polarisation of photons produced in $b \\to s\\gamma$ transitions. More work is needed both experimentally and theoretically to understand if the Standard Model description of these rare FCNC processes is correct.

  19. Defining and identifying Sleeping Beauties in science

    CERN Document Server

    Ke, Qing; Radicchi, Filippo; Flammini, Alessandro

    2015-01-01

    A Sleeping Beauty (SB) in science refers to a paper whose importance is not recognized for several years after publication. Its citation history exhibits a long hibernation period followed by a sudden spike of popularity. Previous studies suggest a relative scarcity of SBs. The reliability of this conclusion is, however, heavily dependent on identification methods based on arbitrary threshold parameters for sleeping time and number of citations, applied to small or monodisciplinary bibliographic datasets. Here we present a systematic, large-scale, and multidisciplinary analysis of the SB phenomenon in science. We introduce a parameter-free measure that quantifies the extent to which a specific paper can be considered an SB. We apply our method to 22 million scientific papers published in all disciplines of natural and social sciences over a time span longer than a century. Our results reveal that the SB phenomenon is not exceptional. There is a continuous spectrum of delayed recognition where both the hiberna...

  20. Rare FCNC top, beauty and charm decays

    CERN Document Server

    Blake, T

    2014-01-01

    Rare flavour changing neutral current (FCNC) decays of top, beauty and charm quarks can provide a powerful probe for as yet unobserved particles. Recent results on FCNC $b \\to s$, $c \\to u$ and $t$ transitions from the LHC experiments are reviewed. Particular attention is paid to the angular distribution of the $B^{0} \\to K^{*0} \\mu^{+}\\mu^{-}$ decay, where a measurement performed by LHCb shows a local discrepancy of 3.7 standard deviations with respect to the SM prediction. Using the decay $B^{+} K^{+}\\pi^{-}\\pi^{+}\\gamma$, LHCb have also been able to demonstrate the polarisation of photons produced in $b \\to s \\gamma$ transitions. More work is needed both experimentally and theoretically to understand if the Standard Model description of these rare FCNC processes is correct.

  1. Why Beauty Still Cannot Be Measured

    Directory of Open Access Journals (Sweden)

    Ossi Naukkarinen

    2010-01-01

    Full Text Available This article focuses on the question of whether the latest results achieved in sciences such as evolution studies and brain research can help us understand the nature of aesthetic judgments. It suggests that such approaches may offer interesting insights for understanding many problems in aesthetics, but for clarifying aesthetic judgments one needs a philosophical point of view. Aesthetic judgments cannot be proven right or wrong by scientific methods, and beauty or other aesthetic qualities cannot be directly measured. The “method” of both making and analyzing aesthetic judgments is discussion, and the article clarifies why this is still the case, even if empirical, non-philosophical scientific methods are more accurate than ever before.

  2. Truth and beauty in contemporary urban photography

    Directory of Open Access Journals (Sweden)

    Daniele Colistra

    2014-05-01

    Full Text Available Does city still need photography? Or does it show itself more effectively through other forms of communication? The question brings us back almost two hundred years ago, at the time of the spread of the first daguerreotypes, when the query was: Does city still need painting? The question raises several other issues - truth and beauty, analogical and digital, truth and photo editing - that this essay examines by comparing some images. We are convinced that “the more we can speak of a picture, the more unlikely it is to speak of photography” (R. Barthes. The essay describes the work of some artists/photographers who have addressed the issue of urban photography. Works in which the figurative and visionary component is based on the interaction of traditional shooting techniques and processes of digital post-production.

  3. The 2012 interferometric imaging beauty contest

    Science.gov (United States)

    Baron, Fabien; Cotton, William D.; Lawson, Peter R.; Ridgway, Steve T.; Aarnio, Alicia; Monnier, John D.; Hofmann, Karl-Heinz; Schertl, Dieter; Weigelt, Gerd; Thiébaut, Eric; Soulez, Férréol; Mary, David; Millour, Florentin; Vannier, Martin; Young, John; Elias, Nicholas M.; Schmitt, Henrique R.; Rengaswamy, Sridharan

    2012-07-01

    We present the results of the fifth Interferometric Imaging Beauty Contest. The contest consists in blind imaging of test data sets derived from model sources and distributed in the OIFITS format. Two scenarios of imaging with CHARA/MIRC-6T were offered for reconstruction: imaging a T Tauri disc and imaging a spotted red supergiant. There were eight different teams competing this time: Monnier with the software package MACIM; Hofmann, Schertl and Weigelt with IRS; Thiebaut and Soulez with MiRA ; Young with BSMEM; Mary and Vannier with MIROIRS; Millour and Vannier with independent BSMEM and MiRA entries; Rengaswamy with an original method; and Elias with the radio-astronomy package CASA. The contest model images, the data delivered to the contestants and the rules are described as well as the results of the image reconstruction obtained by each method. These results are discussed as well as the strengths and limitations of each algorithm.

  4. Fractal Beauty in Xinjiang Folk Art Patterns

    Institute of Scientific and Technical Information of China (English)

    PENG Hong; ZHAO Hai-ying

    2014-01-01

    Xinjiang folk art patterns and designs are the art treasures of Chinese cultural treasure-house as well as the precious humanistic resources of Western China. In the process of collecting, sorting out and studying Xinjiang folk art patterns, the elegant simplicity as well as the good taste stands out impressively, and the pattern shape as well as the layout composition shows a distinctive national trait and a strong local color. As “The Geometry of Nature”, fractal geometry brings about a new performing method. Various fractal graphs are created by different generators. Their dynamic pictures contain visual information of great magnitude and their artistic effect is similar to Xinjiang folk art patterns, which fully proves the fractal beauty in Xinjiang folk art patterns.

  5. The 2012 Interferometric Imaging Beauty Contest

    CERN Document Server

    Baron, Fabien; Lawson, Peter R; Ridgway, Steve T; Aarnio, Alicia; Monnier, John D; Hofmann, Karl-Heinz; Schertl, Dieter; Weigelt, Gerd; Thiébaut, Eric; Soulez, Férréol; Mary, David; Millour, Florentin; Vannier, Martin; Young, John; Elias, Nicholas M; Schmitt, Henrique R; Rengaswamy, Sridharan

    2012-01-01

    We present the results of the fifth Interferometric Imaging Beauty Contest. The contest consists in blind imaging of test data sets derived from model sources and distributed in the OIFITS format. Two scenarios of imaging with CHARA/MIRC-6T were offered for reconstruction: imaging a T Tauri disc and imaging a spotted red supergiant. There were eight different teams competing this time: Monnier with the software package MACIM; Hofmann, Schertl and Weigelt with IRS; Thi\\'ebaut and Soulez with MiRA ; Young with BSMEM; Mary and Vannier with MIROIRS; Millour and Vannier with independent BSMEM and MiRA entries; Rengaswamy with an original method; and Elias with the radio-astronomy package CASA. The contest model images, the data delivered to the contestants and the rules are described as well as the results of the image reconstruction obtained by each method. These results are discussed as well as the strengths and limitations of each algorithm.

  6. Isovector and hidden-beauty partners of the X(3872)

    International Nuclear Information System (INIS)

    The isovector partners of the X(3872), recently found at BES III, Belle and CLEO-c were predicted in a simple model based on the chromomagnetic interaction among quarks. The extension to the hidden-beauty sector is discussed.

  7. Isovector and hidden-beauty partners of the X(3872)

    Energy Technology Data Exchange (ETDEWEB)

    Høgaasen, Hallstein, E-mail: hallstein.hogasen@fys.uio.no [Department of Physics, University of Oslo, Box 1048, NO-0316 Oslo (Norway); Kou, Emi, E-mail: kou@lal.in2p3.fr [Laboratoire de l' Accélérateur Linéaire, Université Paris-Sud, IN2P3-CNRS, Centre Scientifique d' Orsay, 91898 Orsay Cedex (France); Richard, Jean-Marc, E-mail: j-m.richard@ipnl.in2p3.fr [Université de Lyon, Institut de Physique Nucléaire de Lyon, UCBL–IN2P3-CNRS, 4, rue Enrico Fermi, 69622 Villeurbanne Cedex (France); Sorba, Paul, E-mail: paul.sorba@lapth.cnrs.fr [LAPTh, Laboratoire d' Annecy-le-Vieux de Physique Théorique, CNRS, Université de Savoie, BP 110, 74941 Annecy-le-Vieux Cedex (France)

    2014-05-01

    The isovector partners of the X(3872), recently found at BES III, Belle and CLEO-c were predicted in a simple model based on the chromomagnetic interaction among quarks. The extension to the hidden-beauty sector is discussed.

  8. Measurement of beauty production in DIS and extraction at ZEUS

    Energy Technology Data Exchange (ETDEWEB)

    Abramowicz, H.; Ingbir, R.; Kananov, S.; Levy, A.; Stern, A. [Tel Aviv University, Raymond and Beverly Sackler Faculty of Exact Sciences, School of Physics, Tel Aviv (Israel); Abt, I.; Caldwell, A.; Kollar, D.; Reisert, B.; Schmidke, W.B. [Max-Planck-Institut fuer Physik, Muenchen (Germany); Adamczyk, L.; Bold, T.; Gach, G.; Grabowska-Bold, I.; Kisielewska, D.; Przybycien, M.; Suszycki, L. [AGH-University of Science and Technology, Faculty of Physics and Applied Computer Science, Cracow (Poland); Adamus, M.; Plucinski, P.; Tymieniecka, T. [Institute for Nuclear Studies, Warsaw (Poland); Aggarwal, R.; Kaur, M.; Kaur, P.; Singh, I. [Panjab University, Department of Physics, Chandigarh (India); Antonelli, S.; Basile, M.; Bindi, M.; Cifarelli, L.; Contin, A.; De Pasquale, S.; Sartorelli, G.; Zichichi, A. [University Bologna (Italy); INFN Bologna, Bologna (Italy); Antonioli, P.; Bari, G.; Bellagamba, L.; Boscherini, D.; Bruni, A.; Bruni, G.; Cindolo, F.; Corradi, M.; Iacobucci, G.; Margotti, A.; Nania, R.; Polini, A. [INFN Bologna, Bologna (Italy); Antonov, A.; Dolgoshein, B.A.; Gladkov, D.; Sosnovtsev, V.; Stifutkin, A.; Suchkov, S. [Moscow Engineering Physics Institute, Moscow (Russian Federation); Arneodo, M.; Ruspa, M. [Universita del Piemonte Orientale, Novara (Italy); INFN, Torino (Italy); Aushev, V.; Aushev, Y.; Borodin, M.; Gogota, O.; Kadenko, I.; Korol, I.; Kuprash, O.; Lontkovskyi, D.; Makarenko, I.; Onishchuk, Yu.; Salii, A.; Tomalak, O.; Viazlo, V.; Volynets, O.; Zenaiev, O.; Zhmak, N.; Zolko, M. [National Academy of Sciences, and Kiev National University, Institute for Nuclear Research, Kiev (Ukraine); Bachynska, O.; Behnke, O.; Behr, J.; Behrens, U.; Blohm, C.; Borras, K.; Bot, D.; Ciesielski, R.; Coppola, N.; Fang, S.; Geiser, A.; Goettlicher, P.; Grebenyuk, J.; Gregor, I.; Haas, T.; Hain, W.; Huettmann, A.; Januschek, F.; Kahle, B.; Katkov, I.I.; Klein, U.; Koetz, U.; Kowalski, H.; Libov, V.; Lisovyi, M.; Lobodzinska, E. [and others

    2010-10-15

    Beauty production in deep inelastic scattering with events in which a muon and a jet are observed in the final state has been measured with the ZEUS detector at HERA using an integrated luminosity of 114 pb{sup -1}. The fraction of events with beauty quarks in the data was determined using the distribution of the transverse momentum of the muon relative to the jet. The cross section for beauty production was measured in the kinematic range of photon virtuality, Q{sup 2}>2 GeV{sup 2}, and inelasticity, 0.05beauty contribution to the structure function F{sub 2} was extracted and is compared to theoretical predictions. (orig.)

  9. Trinity and beauty: The theological contribution of Jonathan Edwards

    Directory of Open Access Journals (Sweden)

    R. Venter

    2012-02-01

    Full Text Available The article explores the relationship between the trinitarian confession of God and beauty. Special attention is paid to Jonathan Edwards, the eighteenth-centur ypreacher and thinker, who in an exceptional manner viewed God in terms of beauty. The discussion is located in the context of a vigorous international Edwardsian scholarship on metaphysics, the nature of God and aesthetics. The article points out that beauty, according to Edwards, is primarily relational. The article aims at contributing to two neglected scholarly areas – the treatment of the doctrine of God in aesthetic terms, and the study of Jonathan Edwards in a South African context. Areas for further reflection are also identified. The article intimates that a discussion about trinity and beauty may have social ramifications.

  10. Can we measure beauty? Computational evaluation of coral reef aesthetics

    NARCIS (Netherlands)

    A.F. Haas; M. Guibert; A. Foerschner; T. Co; S. Calhoun; E. George; M. Hatay; E. Dinsdale; S.A. Sandin; J.E. Smith; M.J.A. Vermeij; B. Felts; P. Dustan; P. Salamon; F. Rohwer

    2015-01-01

    The natural beauty of coral reefs attracts millions of tourists worldwide resulting in substantial revenues for the adjoining economies. Although their visual appearance is a pivotal factor attracting humans to coral reefs current monitoring protocols exclusively target biogeochemical parameters, ne

  11. Sunflower Beauty Contest : tsvetõ zimoi / Marina Poltavtseva

    Index Scriptorium Estoniae

    Poltavtseva, Marina

    2001-01-01

    Lillekleitide võistlusest Sunflower Beauty Contest Tallinna klubis Decolte. Konkursi idee on florist Tatjana Tridvornovalt. Esimese koha sai Viimsi lilleäri lilleseadjate Meri-Liis Kõivu ja Triinu Põlderi lillekleit "Talvepruut"

  12. Measurement of beauty production from dimuon events at HERA

    CERN Document Server

    Chekanov, S; Magill, S; Musgrave, B; Nicholass, D; Repond, J; Yoshida, R; Mattingly, M C K; Antonioli, P; Bari, G; Bellagamba, L; Boscherini, D; Bruni, A; Bruni, G; Cindolo, F; Corradi, M; Iacobucci, G; Margotti, A; Nania, R; Polini, A; Antonelli, S; Basile, M; Bindi, M; Cifarelli, L; Contin, A; DePasquale, S; Sartorelli, G; Zichichi, A; Bartsch, D; Brock, I; Hartmann, H; Hilger, E; Jakob, H P; Jüngst, M; Nuncio-Quiroz, A E; Paul, E; Samson, U; Schonberg, V; Shehzadi, R; Wlasenko, M; Brook, N H; Heath, G P; Morris, J D; Kaur, M; Kaur, P; Singh, I; Capua, M; Fazio, S; Mastroberardino, A; Schioppa, M; Susinno, G; Tassi, E; Kim, J Y; Ibrahim, Z A; Kamaluddin, B; WanAbdullah, W A T; Ning, Y; Ren, Z; Sciulli, F; Chwastowski, J; Eskreys, A; Figiel, J; Galas, A; Olkiewicz, K; Stopa, P; Zawiejski, L; Adamczyk, L; Bold, T; Grabowska-Bold, I; Kisielewska, D; Lukasik, J; Przybycien, M; Suszycki, L; Kotanski, A; Slominski, W; Behnke, O; Behrens, U; Bloch, I; Blohm, C; Bonato, A; Borras, K; Bot, D; Ciesielski, R; Coppola, N; Fang, S; Fourletova, J; Geiser, A; Göttlicher, P; Grebenyuk, J; Gregor, I; Gutsche, O; Haas, T; Hain, W; Huttmann, A; Januschek, F; Kahle, B; Katkov, I; Klein, U; Kötz, U; Kowalski, H; Lisovyi, M; Lobodzinska, E; Löhr, B; Mankel, R; Melzer-Pellmann, I A; Miglioranzi, S; Montanari, A; Namsoo, T; Notz, D; Parenti, A; Rinaldi, L; Roloff, P; Rubinsky, I; Schneekloth, U; Spiridonov, A; Szuba, D; Szuba, J; Theedt, T; Ukleja, J; Wolf, G; Wrona, K; YaguesMolina, A G; Youngman, C; Zeuner, W; Drugakov, V; Lohmann, W; Schlenstedt, S; Barbagli, G; Gallo, E; Pelfer, P G; Bamberger, A; Dobur, D; Karstens, F; Vlasov, N N; Bussey, P J; Doyle, A T; Dunne, W; Forrest, M; Rosin, M; Saxon, D H; Skillicorn, I O; Gialas, I; Papageorgiu, K; Holm, U; Klanner, R; Lohrmann, E; Perrey, H; Schleper, P; Schörner-Sadenius, T; Sztuk, J; Stadie, H; Turcato, M; Foudas, C; Fry, C; Long, K R; Tapper, A D; Matsumoto, T; Nagano, K; Tokushuku, K; Yamada, S; Yamazaki, Y; Barakbaev, A N; Boos, E G; Pokrovskiy, N S; Zhautykov, B O; Aushev, V; Bachynska, O; Borodin, M; Kadenko, I; Kozulia, A; Libov, V; Lontkovskyi, D; Makarenko, I; Sorokin, Iu; Verbytskyi, A; Volynets, O; Son, D; deFavereau, J; Piotrzkowski, K; Barreiro, F; Glasman, C; Jiménez, M; Labarga, L; delPeso, J; Ron, E; Soares, M; Terron, J; Zambrana, M; Corriveau, F; Liu, C; Schwartz, J; Walsh, R; Zhou, C; Tsurugai, T; Antonov, A; Dolgoshein, B A; Gladkov, D; Sosnovtsev, V; Stifutkin, A; Suchkov, S; Dementiev, R K; Ermolov, P F; Gladilin, L K; Golubkov, Yu A; Khein, L A; Korzhavina, I A; Kuzmin, V A; Levchenko, B B; Lukina, O Yu; Proskuryakov, A S; Shcheglova, L M; Zotkin, D S; Abt, I; Caldwell, A; Kollar, D; Reisert, B; Schmidke, W B; Grigorescu, G; Keramidas, A; Koffeman, E; Kooijman, P; Pellegrino, A; Tiecke, H; Vázquez, M; Wiggers, L; Brümmer, N; Bylsma, B; Durkin, L S; Lee, A; Ling, T Y; Allfrey, P D; Bell, M A; Cooper-Sarkar, A M; Devenish, R C E; Ferrando, J; Foster, B; Gwenlan, C; Korcsak-Gorzo, K; Oliver, K; Robertson, A; Uribe-Estrada, C; Walczak, R; Bertolin, A; Dal Corso, F; Dusini, S; Longhin, A; Stanco, L; Bellan, P; Brugnera, R; Carlin, R; Garfagnini, A; Limentani, S; Oh, B Y; Raval, A; Whitmore, J J; Iga, Y; D'Agostini, G; Marini, G; Nigro, A; Cole, J E; Hart, J C; Abramowicz, H; Ingbir, R; Kananov, S; Levy, A; Stern, A; Kuze, M; Maeda, J; Hori, R; Kagawa, S; Okazaki, N; Shimizu, S; Tawara, T; Hamatsu, R; Kaji, H; Kitamura, S; Ota, O; Ri, Y D; Costa, M; Ferrero, M I; Monaco, V; Sacchi, R; Solano, A; Arneodo, M; Ruspa, M; Fourletov, S; Martin, J F; Stewart, T P; Boutle, S K; Butterworth, J M; Jones, T W; Loizides, J H; Wing, M; Brzozowska, B; Ciborowski, J; Grzelak, G; Kulinski, P; Luzniak, P; Malka, J; Nowak, R J; Pawlak, J M; Perlanski, W; Tymieniecka, T; Zarnecki, A F; Adamus, M; Plucinsky, P P; Ukleja, A; Eisenberg, Y; Hochman, D; Karshon, U; Brownson, E; Reeder, D D; Savin, A A; Smith, W H; Wolfe, H; Bhadra, S; Catterall, C D; Cui, Y; Hartner, G; Menary, S; Noor, U; Standage, J; Whyte, J

    2009-01-01

    Beauty production in events containing two muons in the final state has been measured with the ZEUS detector at HERA using an integrated luminosity of 114 pb-1. A low transverse-momentum threshold for muon identification, in combination with the large rapidity coverage of the ZEUS muon system, gives access to almost the full phase space for beauty production. The total cross section for beauty production in ep collisions at sqrt(s)= 318 GeV has been measured to be sigma_tot(ep -> bbbar X) = 13.9 +- 1.5(stat.) +4.0 -4.3(syst.) nb. Differential cross sections and a measurement of bbbar correlations are also obtained, and compared to other beauty cross-section measurements, Monte Carlo models and next-to-leading-order QCD predictions.

  13. The Reformation of Beauty. Protestantism and Spiritual Roots of Functionalism

    Czech Academy of Sciences Publication Activity Database

    Bolom-Kotari, Sixtus

    Brno: Masarykova univerzita, 2015 - (Galeta, J.; Ragulová, Z.), s. 261-278 ISBN 978-80-210-8092-8 Institutional support: RVO:67985963 Keywords : Beauty * Reformation * Protestantism * Enlightenment * Functionalism * Traditionalism Subject RIV: AB - History

  14. Aesthetic experience of beautiful and ugly persons: a critique

    Directory of Open Access Journals (Sweden)

    Mika Suojanen

    2016-03-01

    Full Text Available The question of whether or not beauty exists in nature is a philosophical problem. In particular, there is the question of whether artworks, persons, or nature has aesthetic qualities. Most people say that they care about their own beauty. Moreover, they judge another person's appearance from an aesthetic point of view using aesthetic concepts. However, aesthetic judgements are not objective in the sense that the experience justifies their objectivity. By analysing Monroe C. Beardsley's theory of the objectivity of aesthetic qualities, I examine whether there are really beautiful and ugly persons in the world. I will criticize the way analytic philosophers judge people and art from an aesthetic perspective. If there are no aesthetic qualities in the world, nobody can judge someone beautiful or ugly without oppression. Aesthetic judgement is exercise of power.

  15. Collider phenomenology of light strange-beauty squarks

    International Nuclear Information System (INIS)

    Strong mixing between right-handed strange and beauty squarks is a possible solution to the CP violation discrepancy in B→φKS decay as recently suggested by the Belle data. In this scenario, thanks to the strong mixing one of the strange-beauty squarks can be as light as 200 GeV, even though the generic supersymmetry scale is at TeV. In this work, we study the production of this light right-handed strange-beauty squark at hadronic colliders and discuss the detection in various decay scenarios. Detection prospect at the Tevatron run II is good for the strange-beauty squark mass up to about 300 GeV

  16. Measurement of beauty production from dimuon events at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Chekanov, S.; Derrick, M.; Magill, S. [Argonne National Laboratory, Argonne, IL (United States)] (and others)

    2008-09-15

    Beauty production in events containing two muons in the final state has been measured with the ZEUS detector at HERA using an integrated luminosity of 114 pb{sup -1}. A low transverse-momentum threshold for muon identification, in combination with the large rapidity coverage of the ZEUS muon system, gives access to almost the full phase space for beauty production. The total cross section for beauty production in ep collisions at {radical}(s) = 318 GeV has been measured to be {sigma}{sub tot}(ep {yields} b anti bX) = 13.9 {+-} 1.5(stat.){sub -4.3}{sup +4.0}(syst.) nb. Differential cross sections and a measurement of b anti b correlations are also obtained, and compared to other beauty cross-section measurements, Monte Carlo models and next-to-leading-order QCD predictions. (orig.)

  17. Employers' Preferences for Gender, Age, Height and Beauty: Direct Evidence

    OpenAIRE

    Peter Kuhn; Kailing Shen

    2009-01-01

    We study firms' advertised preferences for gender, age, height and beauty in a sample of ads from a Chinese internet job board, and interpret these patterns using a simple employer search model. We find that these characteristics are widely and highly valued by Chinese employers, though employers' valuations are highly specific to detailed jobs and occupations. Consistent with our model, advertised preferences for gender, age, height and beauty all become less prevalent as job skill requireme...

  18. DEVELOPMENT PROCESS OF BEAUTY AND HOLISM IN IRAN MOSQUE ARCHITECTURE

    OpenAIRE

    SHOJAEE, Farshid; PAEEZE, Mehran

    2015-01-01

    Abstract. The final goal of this article is to explain the accurate meaning of beauty ,finding general criteria of these concepts ,and mixing and their concrete appearance in Islamic architecture ,in particular mosques .Since finding a unique and basic definition for beauty in Islamic art and architecture requires vast research and existing definitions in Western and Islamic  philosophy  ,art, and architecture are significantly different , this research tries to explain these concepts clearly...

  19. Aesthetic experience of beautiful and ugly persons: a critique

    OpenAIRE

    Suojanen, Mika

    2016-01-01

    The question of whether or not beauty exists in nature is a philosophical problem. In particular, there is the question of whether artworks, persons, or nature has aesthetic qualities. Most people say that they care about their own beauty. Moreover, they judge another person’s appearance from an aesthetic point of view using aesthetic concepts. However, aesthetic judgements are not objective in the sense that the experience justifies their objectivity. By analysing Monroe C. Beardsley’s theor...

  20. Can We Model the Scenic Beauty of an Alpine Landscape?

    OpenAIRE

    Erich Tasser; Ulrike Tappeiner; Georg Leitinger; Maria Bacher; Sonja Hölzler; Uta Schirpke

    2013-01-01

    During the last decade, agriculture has lost its importance in many European mountain regions and tourism, which benefits from attractive landscapes, has become a major source of income. Changes in landscape patterns and elements might affect scenic beauty and therefore the socio-economic welfare of a region. Our study aimed at modeling scenic beauty by quantifying the influence of landscape elements and patterns in relationship to distance. Focusing on Alpine landscapes in South and North Ty...

  1. Reprogramming of Human Fibroblasts to Induced Pluripotent Stem Cells with Sleeping Beauty Transposon-Based Stable Gene Delivery.

    Science.gov (United States)

    Sebe, Attila; Ivics, Zoltán

    2016-01-01

    Human induced pluripotent stem (iPS) cells are a source of patient-specific pluripotent stem cells and resemble human embryonic stem (ES) cells in gene expression profiles, morphology, pluripotency, and in vitro differentiation potential. iPS cells are applied in disease modeling, drug screenings, toxicology screenings, and autologous cell therapy. In this protocol, we describe how to derive human iPS cells from fibroblasts by Sleeping Beauty (SB) transposon-mediated gene transfer of reprogramming factors. First, the components of the non-viral Sleeping Beauty transposon system, namely a transposon vector encoding reprogramming transcription factors and a helper plasmid expressing the SB transposase, are electroporated into human fibroblasts. The reprogramming cassette undergoes transposition from the transfected plasmids into the fibroblast genome, thereby resulting in stable delivery of the reprogramming factors. Reprogramming by using this protocol takes ~4 weeks, after which the iPS cells are isolated and clonally propagated. PMID:26895068

  2. EZH2-Mediated Inactivation of IFN-γ-JAK-STAT1 Signaling Is an Effective Therapeutic Target in MYC-Driven Prostate Cancer

    Directory of Open Access Journals (Sweden)

    Zhen Ning Wee

    2014-07-01

    Full Text Available Although small-molecule targeting of EZH2 appears to be effective in lymphomas carrying EZH2 activating mutations, finding similar approaches to target EZH2-overexpressing epithelial tumors remains challenging. In MYC-driven, but not PI3K-driven prostate cancer, we show that interferon-γ receptor 1 (IFNGR1 is directly repressed by EZH2 in a MYC-dependent manner and is downregulated in a subset of metastatic prostate cancers. EZH2 knockdown restored the expression of IFNGR1 and, when combined with IFN-γ treatment, led to strong activation of IFN-JAK-STAT1 tumor-suppressor signaling and robust apoptosis. Pharmacologic depletion of EZH2 by the histone-methylation inhibitor DZNep mimicked the effects of EZH2 knockdown on IFNGR1 induction and delivered a remarkable synergistic antitumor effect with IFN-γ. In contrast, although they efficiently depleted histone Lysine 27 trimethylation, EZH2 catalytic inhibitors failed to mimic EZH2 depletion. Thus, EZH2-inactivated IFN signaling may represent a therapeutic target, and patients with advanced prostate cancer driven by MYC may benefit from the combination of EZH2 and IFN-γ-targeted therapy.

  3. Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection

    Directory of Open Access Journals (Sweden)

    Tamayev Robert

    2012-12-01

    Full Text Available Abstract Background Mutations in either Aβ Precursor protein (APP or genes that regulate APP processing, such as BRI2/ITM2B and PSEN1/PSEN2, cause familial dementias. Although dementias due to APP/PSEN1/PSEN2 mutations are classified as familial Alzheimer disease (FAD and those due to mutations in BRI2/ITM2B as British and Danish dementias (FBD, FDD, data suggest that these diseases have a common pathogenesis involving toxic APP metabolites. It was previously shown that FAD mutations in APP and PSENs promote activation of caspases leading to the hypothesis that aberrant caspase activation could participate in AD pathogenesis. Results Here, we tested whether a similar mechanism applies to the Danish BRI2/ITM2B mutation. We have generated a genetically congruous mouse model of FDD, called FDDKI, which presents memory and synaptic plasticity deficits. We found that caspase-9 is activated in hippocampal synaptic fractions of FDDKI mice and inhibition of caspase-9 activity rescues both synaptic plasticity and memory deficits. Conclusion These data directly implicate caspase-9 in the pathogenesis of Danish dementia and suggest that reducing caspase-9 activity is a valid therapeutic approach to treating human dementias.

  4. A beautiful question finding nature’s deep design

    CERN Document Server

    Wilczek, Frank

    2015-01-01

    Artists as well as scientists throughout human history have pondered this “beautiful question.” With Nobel laureate Frank Wilczek as your guide, embark on a voyage of related discoveries, from Plato and Pythagoras up to the present. Wilczek’s groundbreaking work in quantum physics was inspired by his intuition to look for a deeper order of beauty in nature. In fact, every major advance in his career came from this intuition: to assume that the universe embodies beautiful forms, forms whose hallmarks are symmetry—harmony, balance, proportion—and economy. There are other meanings of “beauty,” but this is the deep logic of the universe—and it is no accident that it is also at the heart of what we find aesthetically pleasing and inspiring. Wilczek is hardly alone among great scientists in charting his course using beauty as his compass. As he reveals in A Beautiful Question, this has been the heart of scientific pursuit from Pythagoras, the ancient Greek who was the first to argue that “all thi...

  5. The role of tricyclic drugs in selective triggering of mitochondrially-mediated apoptosis in neoplastic glia. A therapeutic option in malignant glioma?

    International Nuclear Information System (INIS)

    We have previously demonstrated that the tricyclic antidepressant, Clomipramine, exerts a concentrationdependant, tumour cell specific, pro-apoptotic effect on human glioma cells in vitro and that this effect is not mirrored in non-neoplastic human astrocytes. Moreover, the drug acts by triggering mitochondrially-mediated apoptosis by way of complex 3 of the respiratory chain. Here, through reduced reactive oxygen species and neoplastic cell specific, altered membrane potential, cytochrome c is released, thereby activating a caspase pathway to apoptosis. In addition, while we and others have shown that further antidepressants, including those of the selective serotonin reuptake inhibitor (SSRI) group, also mediate cancer cell apoptosis in both glioma and lymphoma, clomipramine appears to be most effective in this context. More recently, other groups have reported that clomipramine causes apoptosis, preceded by a rapid increase in p-c-Jun levels, cytochrome c release from mitochondria and increased caspase-3-like activity. In addition to clomipramine we have investigated the possible pro-apoptotic activity of a range of further tricyclic drugs. Only two such agents (amitriptyline and doxepin) showed a similar, or better, effect when compared with clomipramine. Since both orally administered clomipramine and amitriptyline are metabolised to desmethyl clomipramine (norclomipramine) and nortriptyline respectively it is necessary for testing at a tumour cell level to be carried out with both the parent tricyclic and the metabolic product. In addition, reversal of multidrug resistance in a number of solid cancers following treatment with both clomipramine and amitriptyline has been reported. This additional role for tricyclics may be of some significance in the treatment of primary and secondary brain tumours. Since a substantial number of patients with malignant glioma have already received and are receiving clomipramine, both anecdotally and within a clinical trial, we

  6. Response rate of fibrosarcoma cells to cytotoxic drugs on the expression level correlates to the therapeutic response rate of fibrosarcomas and is mediated by regulation of apoptotic pathways

    International Nuclear Information System (INIS)

    Because of the high resistance rate of fibrosarcomas against cytotoxic agents clinical chemotherapy of these tumors is not established. A better understanding of the diverse modes of tumor cell death following cytotoxic therapies will provide a molecular basis for new chemotherapeutic strategies. In this study we elucidated the response of a fibrosarcoma cell line to clinically used cytostatic agents on the level of gene expression. HT1080 fibrosarcoma cells were exposed to the chemotherapeutic agents doxorubicin, actinomycin D or vincristine. Total RNA was isolated and the gene expression patterns were analyzed by microarray analysis. Expression levels for 46 selected candidate genes were validated by quantitative real-time PCR. The analysis of the microarray data resulted in 3.309 (actinomycin D), 1.019 (doxorubicin) and 134 (vincristine) probesets that showed significant expression changes. For the RNA synthesis blocker actinomycin D, 99.4% of all differentially expressed probesets were under-represented. In comparison, probesets down-regulated by doxorubicin comprised only 37.4% of all genes effected by this agent. Closer analysis of the differentially regulated genes revealed that doxorubicin induced cell death of HT1080 fibrosarcoma cells mainly by regulating the abundance of factors mediating the mitochondrial (intrinsic) apoptosis pathway. Furthermore doxorubicin influences other pathways and crosstalk to other pathways (including to the death receptor pathway) at multiple levels. We found increased levels of cytochrome c, APAF-1 and members of the STAT-family (STAT1, STAT3), while Bcl-2 expression was decreased. Caspase-1, -3, -6, -8, and -9 were increased indicating that these proteases are key factors in the execution of doxorubicin mediated apoptosis. This study demonstrates that chemotherapy regulates the expression of apoptosis-related factors in fibrosarcoma cells. The number and the specific pattern of the genes depend on the used cytotoxic drug

  7. Therapeutic intervention of proanthocyanidins on the migration capacity of melanoma cells is mediated through PGE2 receptors and β-catenin signaling molecules.

    Science.gov (United States)

    Vaid, Mudit; Singh, Tripti; Prasad, Ram; Kappes, John C; Katiyar, Santosh K

    2015-01-01

    Melanoma is a highly aggressive form of skin cancer and a leading cause of death from skin diseases mainly due to its propensity to metastasis. Due to metastatic tendency, melanoma is often associated with activation of Wnt/β-catenin signaling mechanism. Blocking β-catenin activation may be a good strategy to block melanoma-associated mortality. We have shown earlier that grape seed proanthocyanidins (GSPs) inhibit melanoma cell migration via targeting cyclooxygenase-2 (COX-2) overexpression. Here we explored further whether inhibition of inflammatory mediators-mediated activation of β-catenin by GSPs is associated with the inhibition of melanoma cell migration. Our study revealed that PGE2 receptors (EP2 and EP4) agonists promote melanoma cell migration while PGE2 receptor antagonist suppressed the migration capacity of melanoma cells. GSPs treatment inhibit butaprost (EP2 agonist) or Cay10580 (EP4 agonist) induced migration of melanoma cells. Western blot analysis revealed that GSPs reduced cellular accumulation of β-catenin, and decreased the expressions of matrix metalloproteinase (MMP)-2, MMP-9 and MITF, downstream targets of β-catenin in melanoma cells. GSPs also reduced the protein expressions of PI3K and p-Akt in the same set of experiment. To verify that β-catenin is a specific molecular target of GSPs, we compared the effect of GSPs on cell migration of β-catenin-activated (Mel1241) and β-catenin-inactivated (Mel1011) melanoma cells. GSPs inhibit cell migration of Mel1241 cells but not of Mel1011 cells. Additionally, in vivo bioluminescence imaging data indicate that dietary administration of GSPs (0.5%, w/w) in supplementation with AIN76A control diet inhibited the migration/extravasation of intravenously injected melanoma cells in lungs of immune-compromised nude mice, and that this effect of GSPs was associated with an inhibitory effect on the activation of β-catenin and its downstream targets, such as MMPs, in lungs as a target organ. PMID

  8. Stromelysin-3 induction and interstitial collagenase repression by retinoic acid. Therapeutical implication of receptor-selective retinoids dissociating transactivation and AP-1-mediated transrepression.

    Science.gov (United States)

    Guérin, E; Ludwig, M G; Basset, P; Anglard, P

    1997-04-25

    Human stromelysin-3 and interstitial collagenase are matrix metalloproteinases whose expression by stromal cells in several types of carcinomas has been associated with cancer progression. We compared here the regulation of the expression of both proteinases by retinoids in human fibroblasts. Physiological concentrations of retinoic acid were found to simultaneously induce stromelysin-3 and repress interstitial collagenase. In both cases, the involvement of a transcriptional mechanism was supported by run-on assays. Furthermore, in transient transfection experiments, the activity of the stromelysin-3 promoter was induced by retinoic acid through endogenous receptors acting on a DR1 retinoic acid-responsive element. The ligand-dependent activation of the receptors was also investigated by using selective synthetic retinoids, and we demonstrated that retinoic acid-retinoid X receptor heterodimers were the most potent functional units controlling both stromelysin-3 induction and interstitial collagenase repression. However, specific retinoids dissociating the transactivation and the AP-1-mediated transrepression functions of the receptors were found to repress interstitial collagenase without inducing stromelysin-3. These findings indicate that such retinoids may represent efficient inhibitors of matrix metalloproteinase expression in the treatment of human carcinomas. PMID:9111003

  9. Therapeutic Nanodevices

    Science.gov (United States)

    Lee, Stephen; Ruegsegger, Mark; Barnes, Philip; Smith, Bryan; Ferrari, Mauro

    Therapeutic nanotechnology offers minimally invasive therapies with high densities of function concentrated in small volumes, features that may reduce patient morbidity and mortality. Unlike other areas of nanotechnology, novel physical properties associated with nanoscale dimensionality are not the raison d'être of therapeutic nanotechnology, whereas the aggregation of multiple biochemical (or comparably precise) functions into controlled nanoarchitectures is. Multifunctionality is a hallmark of emerging nanotherapeutic devices, and multifunctionality can allow nanotherapeutic devices to perform multistep work processes, with each functional component contributing to one or more nanodevice subroutine such that, in aggregate, subroutines sum to a cogent work process. Cannonical nanotherapeutic subroutines include tethering (targeting) to sites of disease, dispensing measured doses of drug (or bioactive compound), detection of residual disease after therapy and communication with an external clinician/operator. Emerging nanotherapeutics thus blur the boundaries between medical devices and traditional pharmaceuticals. Assembly of therapeutic nanodevices generally exploits either (bio)material self-assembly properties or chemoselective bioconjugation techniques, or both. Given the complexity, composition, and the necessity for their tight chemical and structural definition inherent in the nature of nanotherapeutics, their cost of goods (COGs) might exceed that of (already expensive) biologics. Early therapeutic nanodevices will likely be applied to disease states which exhibit significant unmet patient need (cancer and cardiovascular disease), while application to other disease states well-served by conventional therapy may await perfection of nanotherapeutic design and assembly protocols.

  10. Feedlot therapeutics.

    Science.gov (United States)

    Apley, M D; Fajt, V R

    1998-07-01

    This article discusses therapeutic approaches to conditions commonly encountered in feedlots. Challenges discussed include bovine respiratory complex, tracheal edema, atypical interstitial pneumonia, footrot, toe abscesses, mycoplasma arthritis, cardiovascular disease, lactic acidosis, bloat, coccidiosis, central nervous system diseases, abscesses and cellulitis, pregnancy management and abortion, and ocular disease. PMID:9704416

  11. Mathematics make microbes beautiful, beneficial, and bountiful.

    Science.gov (United States)

    Jungck, John R

    2012-01-01

    Microbiology is a rich area for visualizing the importance of mathematics in terms of designing experiments, data mining, testing hypotheses, and visualizing relationships. Historically, Nobel Prizes have acknowledged the close interplay between mathematics and microbiology in such examples as the fluctuation test and mutation rates using Poisson statistics by Luria and Delbrück and the use of graph theory of polyhedra by Caspar and Klug. More and more contemporary microbiology journals feature mathematical models, computational algorithms and heuristics, and multidimensional visualizations. While revolutions in research have driven these initiatives, a commensurate effort needs to be made to incorporate much more mathematics into the professional preparation of microbiologists. In order not to be daunting to many educators, a Bloom-like "Taxonomy of Quantitative Reasoning" is shared with explicit examples of microbiological activities for engaging students in (a) counting, measuring, calculating using image analysis of bacterial colonies and viral infections on variegated leaves, measurement of fractal dimensions of beautiful colony morphologies, and counting vertices, edges, and faces on viral capsids and using graph theory to understand self assembly; (b) graphing, mapping, ordering by applying linear, exponential, and logistic growth models of public health and sanitation problems, revisiting Snow's epidemiological map of cholera with computational geometry, and using interval graphs to do complementation mapping, deletion mapping, food webs, and microarray heatmaps; (c) problem solving by doing gene mapping and experimental design, and applying Boolean algebra to gene regulation of operons; (d) analysis of the "Bacterial Bonanza" of microbial sequence and genomic data using bioinformatics and phylogenetics; (e) hypothesis testing-again with phylogenetic trees and use of Poisson statistics and the Luria-Delbrück fluctuation test; and (f) modeling of

  12. D-Amino Acid Substitution of Peptide-Mediated NF-κB Suppression in mdx Mice Preserves Therapeutic Benefit in Skeletal Muscle, but Causes Kidney Toxicity.

    Science.gov (United States)

    Reay, Daniel P; Bastacky, Sheldon I; Wack, Kathryn E; Stolz, Donna B; Robbins, Paul D; Clemens, Paula R

    2015-01-01

    In Duchenne muscular dystrophy (DMD) patients and the mdx mouse model of DMD, chronic activation of the classical nuclear factor-κB (NF-κB) pathway contributes to the pathogenesis that causes degeneration of muscle fibers, inflammation and fibrosis. Prior studies demonstrate that inhibition of inhibitor of κB kinase (IKK)-mediated NF-κB activation using L-isomer NF-κB essential modulator (NEMO)-binding domain (NBD) peptide-based approaches reduce muscle pathology in the mdx mouse. For our studies, the NBD peptide is synthesized as a fusion peptide with an eight-lysine (8K) protein transduction domain to facilitate intracellular delivery. We hypothesized that the d-isoform peptide could have a greater effect than the naturally occurring L-isoform peptide due to the longer persistence of the D-isoform peptide in vivo. In this study, we compared systemic treatment with low (1 mg/kg) and high (10 mg/kg) doses of L- and D-isomer 8K-wild-type-NBD peptide in mdx mice. Treatment with both L- or D-isoform 8K-wild-type-NBD peptide resulted in decreased activation of NF-κB and improved histology in skeletal muscle of the mdx mouse. However, we observed kidney toxicity (characterized by proteinuria), increased serum creatinine, activation of NF-κB and pathological changes in kidney cortex that were most severe with treatment with the D-isoform of 8K-wild-type-NBD peptide. The observed toxicity was also seen in normal mice. PMID:26018805

  13. Beauty physics in lattice gauge theory

    International Nuclear Information System (INIS)

    We summarize the present status of lattice gauge theory computations of the leptonic decay constants fD and fB. The various sources of systematic errors are explained in a manner easily understood by the non-expert. The results obtained by the different groups are then systematically compared. As a result, we derive estimates for fD and fB in the quenched approximation through an appropriate combination of the data available from the different groups. Since we account for a possible lattice spacing dependence, the final errors are quite large. However, it is now well known how these uncertainties can be reduced. For the decay constant of heavy-light pseudoscalar mesons with masses of 1-2 GeV, an interesting comparison of a full QCD result with the corresponding simulation in the quenched approximation can be done. Effects of sea quarks of mass ms are below the statistical accuracy of these simulations. Related quantities, like B-parameters, the spectrum of beauty-hadrons and the breaking of the QCD string are discussed briefly. (orig.)

  14. Charm and beauty production at LHC

    CERN Document Server

    Carrer, N

    2003-01-01

    We define here the present ALICE baseline for what concerns the heavy flavour production cross sections at LHC and the kinematical distributions of the heavy quark pairs. We start by qualitatively assessing the Bjorken x regimes accessible with charm and beauty measurements at LHC with ALICE (Section 1). In Section 2 we report the most recent results (and the uncertainties) of the next-to-leading order (NLO) pQCD calculations for the cross sections in pp collisions at LHC energies. These results are extrapolated to Pb-Pb collisions in Section 3.1 and to p-Pb collisions in Section 3.2, taking into account nuclear shadowing and parton intrinsic transverse momentum broadening. Heavy quark kinematics as given by the NLO pQCD calculation are reported in Section 4. We tuned the PYTHIA event generator in order to reproduce such results for what concerns the c and b quarks transverse momentum distributions (Section 5). Finally, we report the yields and transverse momentum distributions for D and B mesons (section 6).

  15. Unification: Not Just a Thing of Beauty

    Directory of Open Access Journals (Sweden)

    Ioannis Votsis

    2015-03-01

    Full Text Available We often hear that simplicity, explanatory power and unification, though aesthetically pleasing or beautiful qualities, are at best pragmatic considerations in matters of choosing between rival hypotheses. This paper aims to offer a novel conception and an associated measure of unification, both of which are demonstrably more than just pragmatic considerations. The discussion departs from a brief survey of some failed attempts to carve out adequate conceptions of unification. It then proceeds to an analysis of the notions of confirmational connectedness and disconnectedness. Roughly speaking, these notions attempt to capture the way support propagates or fails to propagate between the content parts of a hypothesis or, equivalently, between the contents of two or more hypotheses. The two notions are instrumental in helping to tackle the problem of ad hoc, and in particular monstrous, hypotheses. More importantly for the purposes of this paper, they are essential ingredients in the proposed conception of unification and its associated measure. In simple terms, the more the content of a hypothesis (or, equivalently, the content of a set of hypotheses is confirmationally connected the more that content is unified. Since the confirmational connectedness of two content parts is determined by purely objective matters of fact, the proposed notion and measure of unification are themselves strictly objective, i.e. not merely pragmatic considerations in matters of hypothesis choice. The paper concludes with a discussion of how the proposed measure handles real and hypothetical examples but also how it stands up to various objections.

  16. Sleeping Beauty: Kleine–Levin Syndrome

    Science.gov (United States)

    Mudgal, Soumiya; Jiloha, R. C.; Kandpal, Manish; Das, Aparna

    2014-01-01

    Kleine–Levin syndrome (KLS) alias sleeping beauty syndrome, is a rare sleep disorder. Clinically presenting as episodes of hypersomnolence, behavioral and cognitive disturbances, hyperphagia and hypersexuality. KLS may have an idiopathic onset or may be precipitated by neurological event or infection. Until date, no definite underlying cause is established and neither there are any definitive management guidelines. It remains a diagnosis of exclusion after other psychiatric and neurological causes have been ruled out. Coloring of presentation with behavioral and mood elements makes it important for a psychiatrist to be well-informed about the condition to avoid the erroneous diagnosis. KLS is a devastating illness, which robs the patient of time, experiences, and relationships. An early diagnosis and effective management can help patient escape from the morbidity caused by this disorder. Armodafinil and oxcarbamazepine have found to be effective in two of the case. The emphasis of this report is to add to the existing clinical knowledge of neurologists, psychiatrists and physicians. In the future, research is needed on genetic etiology and management of this disorder. PMID:25316944

  17. Academic Training: Small may be beautiful

    CERN Multimedia

    Françoise Benz

    2005-01-01

    2004-2005 ACADEMIC TRAINING PROGRAMME LECTURE SERIES 13, 14, 15, 16 and 17 June 13, 14, 16, 17 June from 11:00 to 12:00, 15 June from 10:00 to 12:00 - Auditorium, bldg. 500 Small may be beautiful M. DAVIER / LAL, Orsay, France and T. SOLDNER / ILL, Grenoble, France M. DAVIER 13, 14, 15 June Besides the direct high-energy approach, particle physics frontiers can be explored by low-energy high-sensitivity experiments. These experiments, small on the scale of LHC detectors, can be very effective in reaching a sensitivity level why physics beyond the Standard Model can contribute. In these lectures we will discuss a subject of such experiments (excluding cold neutrons covered in T. Soldner's lectures), their interplay with theory and their impact on our knowledge of new phenomena : anormalous magnetic moments of leptons, weak-electromagnetic interference at low energy and in atomic physics, searches for an electron electric dipole moment in atomic and molecular physics. T. SOLDNER 15, 16, 17 June Neutron pa...

  18. Beautiful mesons from QCD spectral sum rules

    Energy Technology Data Exchange (ETDEWEB)

    Narison, S.

    1988-08-18

    We apply q/sup 2/ = 0 moments within n (number of derivatives) and t/sub c/ (continuum threshold) stability criteria to the beautiful-meson systems. The optimal predictions are reached for the same ranges of n and t/sub c/ values leading to the previous estimate of the decay constant f/sub B/. The QCD scales (b-quark 'physical' mass, mixed and four-quark condensates) are strongly constrained by the observed B and B/sup */ masses. The predictions for the S- and P-state splittings are much affected by the definition of the b-quark mass (pole or euclidian) entering into the Wilson coefficients of the non-perturbative condensates. The size of the SU(3)/sub F/ breaking on the mass splittings cannot be accurately predicted due to the imprecise value of the / condensate ratio. We present new predictions for the B/sub c/ and B/sub c//sup */ mesons.

  19. Artists with Arthritis Create Beauty amid Pain

    Institute of Scientific and Technical Information of China (English)

    Alan; Mozes; 蔡峥伟

    2000-01-01

    得此来稿,我们曾犹豫再三,是否刊用此文。因为,其内容给人的第一印象颇有点离奇。Artists with Arthritis Create Beauty amid Pain,怎么可能呢?细读之下,你也许会觉得,此文虽是一家之言,但也并非荒唐。尤其是本文的收尾句,笔锋一转,抖出了妙言: ...in addition to the emotional support such stories can give RA patients,there are now new drug options that far surpass the treatment choices Renoir faced. 此句是否可译:除了此类故事能够给患风湿病者一种情感上的支持之外,现在可选的新药要比Renoir(雷诺阿,法国印象派画家。主要作品有《包厢》、《游船上的午餐》、《浴女》等。)时代强得多。

  20. pH-Responsive therapeutic solid lipid nanoparticles for reducing P-glycoprotein-mediated drug efflux of multidrug resistant cancer cells

    Directory of Open Access Journals (Sweden)

    Chen HH

    2015-08-01

    enhanced passive tumor accumulation due to the loose intercellular junctions of endothelial cells lining inside blood vessels at tumor site, and the lack of lymphatic drainage. The growth of MCF-7/MDR xenografted tumor on Balb/c nude mice was inhibited to ~400 mm3 in volume as compared with the free DOX treatment group, 1,140 mm3, and the group treated with 1,2 distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol] solid lipid nanoparticles, 820 mm3. Analysis of the body weight of nude mice and the histology of organs and tumor after the administration of DOX-loaded SLNs show that the SLNs have no observable side effects. These results indicate that the C-PEG-SLN is a promising platform for the delivery of therapeutic agents for MDR cancer chemotherapy. Keywords: pH-responsive, solid lipid nanoparticles, multidrug resistance, permeability glycoprotein

  1. Charm and Beauty Production from Secondary Vertexing at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Thompson, Paul [University of Birmingham, Edgbaston, Birmingham, B15 2TT (United Kingdom)

    2010-07-01

    Measurement of the Charm and Beauty Structure Functions using the H1 Vertex Detector at HERA Inclusive charm and beauty cross sections are measured in e{sup -} p and e{sup +}p neutral current collisions at HERA in the kinematic region of photon virtuality 5 < Q{sup 2} < 2000 GeV{sup 2} and Bjorken scaling variable 0.0002 < x < 0.05. The data were collected with the H1 detector in the years 2006 and 2007 corresponding to an integrated luminosity of 189 pb{sup -1}. The numbers of charm and beauty events are determined using variables reconstructed by the H1 vertex detector including the impact parameter of tracks to the primary vertex and the position of the secondary vertex. The measurements are combined with previous data and compared to QCD predictions. Measurement of Charm and Beauty Jets in Deep Inelastic Scattering at HERA Measurements of the charm and beauty jet cross sections have been made in deep inelastic scattering at HERA for the kinematic region of photon virtuality Q{sup 2} > 6 GeV{sup 2} and elasticity variable 0.07 < y < 0.625 for jets in the laboratory frame with transverse energy E{sub T}{sup jet} > 6 GeV and pseudorapidity -1.0 < {eta}{sup jet} < 1.5. Measurements are also made requiring a jet in the Breit frame with E{sub T}{sup jet} > 6 GeV. The data were collected with the H1 detector in the years 2006 and 2007 corresponding to an integrated luminosity of 189 pb{sup -1}. The number of charm and beauty jets are determined using variables reconstructed by the H1 vertex detector including the impact parameter of tracks to the primary vertex and the position of the secondary vertex. The measurements are compared with QCD predictions and with previous measurements obtained using muon tagging. Charm and beauty production in deep inelastic scattering from inclusive secondary vertexing at ZEUS Charm and beauty production in deep inelastic scattering has been measured with the ZEUS detector using the full HERA II data set. The charm and beauty contents

  2. Introducing a "Balance" in The BSC Through Beauty and Love

    Directory of Open Access Journals (Sweden)

    Ari Kamayanti

    2010-04-01

    Full Text Available Celebrating the seventeenth anniversary of the Balanced Score Card (BSC since it was born in 1992, this paper revisits its concept as one of the landmarks in performance measurement. The BSC turns out to be ‘not so balanced’ since it lacks certain beauty and love. It hinges on accountability for certain interests when measuring performance, negating or putting other interests as minority. Thus, it fits perfectly with the aim of management accounting that puts managers and customers as priorities. The imbalances comes from secularism and overemphasis in rationalism. Sustainability that becomes the current issue nowadays would not be supported by such performance measurement. In order to insert this balance, a methodology by taking a methapor of nurturing mother is applied in this research that encompasses gentle beauty and subtle love. Gentle beauty refers to a complete harmony of beauty : irrational and the rational; this means introducing those that have been left out in the name of rationality such as religions and spiritualism. Subtle love refers to love towards God that is expressed subtly without lust to overpower. The result is a more balanced set of performance measurements that are filled with beauty and love, insyaAllah.

  3. Beauty photoproduction using decays into muons at HERA

    International Nuclear Information System (INIS)

    Inclusive cross-sections for the production of open beauty in ep collisions at HERA are measured. The data were recorded with the ZEUS detector between 1996 and 2000. The measurements are restricted to photoproduction processes, i.e. collision events with small four-momentum transfer squared, Q2∼0. Two jets with transverse momentum pT>7(6) GeV and pseudo-rapidities vertical stroke η vertical stroke <2.5 are required. The flavour is tagged by the identification of muons from semi-leptonic decays of the beauty quark. The variable used to discriminate between beauty and background is the transverse momentum of the muon with respect to the jet axis. The fraction of beauty is determined by a fit of Monte Carlo templates to the data. Cross-sections have been measured as a function of the muon and jet variables as well as a function of dijet correlation variables. Dijet correlations in beauty production have been measured for the first time in ZEUS and are found in agreement with QCD NLO predictions. (orig.)

  4. Can We Model the Scenic Beauty of an Alpine Landscape?

    Directory of Open Access Journals (Sweden)

    Erich Tasser

    2013-03-01

    Full Text Available During the last decade, agriculture has lost its importance in many European mountain regions and tourism, which benefits from attractive landscapes, has become a major source of income. Changes in landscape patterns and elements might affect scenic beauty and therefore the socio-economic welfare of a region. Our study aimed at modeling scenic beauty by quantifying the influence of landscape elements and patterns in relationship to distance. Focusing on Alpine landscapes in South and North Tyrol, we used a photographic questionnaire showing different landscape compositions. As mountain landscapes offer long vistas, we related scenic beauty to different distance zones. Our results indicate that the near zone contributes by 64% to the valuation of scenic beauty, the middle zone by 22%, and the far zone by 14%. In contrast to artificial elements, naturalness and diversity increased scenic beauty. Significant differences between different social groups (origin, age, gender, cultural background occurred only between the local population and tourists regarding great landscape changes. Changes towards more homogenous landscapes were perceived negatively, thus political decision makers should support the conservation of the cultural landscape.

  5. ARGUS results on beauty and charm

    International Nuclear Information System (INIS)

    Using the ARGUS detector at the e+e- storage ring DORIS II at DESY new results on beauty and charm physics have been obtained. With more data an update on B0B-bar0 mixing is given for the mixing parameter r = (21±6) %. The investigation of the decay B-bar0 → D*+l-ν allows a determination of the Kobayashi-Maskawa element |Vcb| = 0.052±0.011. The lifetime ratio of charged and neutral B mesons is measured to be τB+/τB0 = 1.00±0.23±0.14. In semileptonic B decays, as well as in exclusive B decays, no significant signals are found for b→u or b→s transitions. In charm physics, the spin of the D*(2459) is shown to be J=2. The enhancement, previously known as the D*(2420), seen in the final state D*(2010)+π-, is resolved into two relatively narrow resonances separated in mass by approximately 40 MeV/c2. The results of a decay angular analysis are in good agreement with the interpretation of the two states as L=1 D mesons of spin-parities 1+ and 2+. The charged isospin partner of the D*(2459)0 is observed at a mass of (2469±4±6) MeV/c2, decaying to D0π+. The isospin mass splitting is measured to be (14±5±8) MeV/c2. Finally, the first excited P-wave Ds meson has been observed in the decay D*s(2536) → D*+Ks0. (author)

  6. The Super Fixed Target beauty facility at the SSC

    International Nuclear Information System (INIS)

    The rationale for pursuing beauty physics at the SSC in a fixed target configuration is described. The increased beauty production cross section at the SSC, combined with high interaction rate capability of the proposed detector, results in 1010-11 produced BB events per year. The long decay length of the B hadrons (≅ 10 cm) allows direct observation of B decays in the high resolution silicon microstrip vertex detector. To optimize the operation of the proposed beauty spectrometer and the SSC, parasitic extraction of attendant or artificially generated large amplitude protons using crystal channeling is proposed and explored. The large sample of fully reconstructed B events allows detailed studies of various CP violating decays with requisite statistics to confront the standard model. The CP physics potential of the proposed experiment is evaluated and compared with alternative approaches, such as symmetric e+e- B Factories and specialized hadron colliders

  7. The Offence of Beauty in Modern Western Art Music

    Directory of Open Access Journals (Sweden)

    Peter Bannister

    2013-12-01

    Full Text Available In recent decades, beauty has become a largely unfashionable, even offensive notion within art and philosophy. As Eastern Orthodox theologian, David Bentley Hart, has pointed out, this offence has a twofold sense. Firstly, the ‘beautiful’ has been dismissed as philosophically insignificant in comparison to the ‘sublime’ by an intellectual tradition tracing itself back to Immanuel Kant’s Critique of Judgment. Secondly, the making of apparently beautiful art has, especially after the Shoah, frequently been regarded as ethically offensive in the face of suffering in the world. The present essay discusses how these two critiques of the beautiful find themselves reflected in twentieth and twenty-first century musical aesthetics, with particular reference to the writings of Theodor W. Adorno, and asks what solutions have been found by composers of Christian sacred music in the Western tradition confronted by this ‘taboo on beauty’.

  8. The beautiful infant and Israel’s salvation

    Directory of Open Access Journals (Sweden)

    James A. Loader

    2011-06-01

    Full Text Available The motif from the Exodus story of Moses as a beautiful infant is considered on several levels. Firstly, the immediate context of Exodus 2 in the Hebrew Bible and in the Septuagint is investigated. Exodus 2 is then related to the reception of the tradition in the New Testament and Jewish sources as well as in a patristic reading and one from the Reformation. The article concludes that the motif of Moses’ beauty is part of a relatively infrequent but nevertheless well-established constellation. It is submitted that this finding contributes to a reappraisal of the idea that the motif of beauty has no place in Israel’s texts of deliverance and an investigation of the contrary hypothesis is called for.

  9. E789 and P865: High-rate fixed-target studies of charm and beauty

    International Nuclear Information System (INIS)

    Experiment 789 at Fermilab used the high-rate E605/E772 spectrometer to study low-multiplicity charm and beauty decays. Preliminary results on charm and beauty production are presented based on analysis of ∼ 100% of the charm data and ∼ 50% of the beauty data. A new experiment is proposed to improve charm and beauty sensitivity by several orders of magnitude

  10. The Creative Reproduction of Chinese Ancient Poetry’s Phonological Beauty in English Translation

    OpenAIRE

    Zhaohui Yan

    2013-01-01

    Phonological beauty is an important aesthetic feature of poetry. Reproduction of Chinese ancient poetry’s phonological beauty in English translation is of great significance. Professor Xu Yuanchong is an accomplished poetry translator who creatively reproduce original Chinese poems’ phonological beauty by employing various techniques such as alliteration, end rhyme, repetition, onomatopoeia, etc. This suggests that Chinese poetry’s phonological beauty can be reproduced in En...

  11. Therapeutic alliance.

    Science.gov (United States)

    Fox, Valerie

    2002-01-01

    I have been very fortunate in my journey of mental illness. I respond well to medication, but I don't think that is the complete answer to living successfully with serious, persistent mental illness. I believe a person's environment is also of utmost importance, enabling the person suffering with mental illness to continually grow in life. I found early in my struggle with mental illness a psychiatrist with whom I have always had a very good rapport. Until recently I didn't know that what I have with this psychiatrist is professionally known as a therapeutic alliance. Over the years, when I need someone to talk over anything that is troubling to me, I seek my psychiatrist. A therapeutic alliance is non-judgmental; it is nourishing; and finally it is a relationship of complete trust. Perhaps persons reading this article who have never experienced this alliance will seek it. I believe it can make an insecure person secure; a frightened person less frightened; and allow a person to continue the journey of mental health with a sense of belief in oneself. PMID:12433224

  12. Beauty in photoproduction at HERA II with the ZEUS detector

    International Nuclear Information System (INIS)

    The production of beauty quarks in ep collisions should be accurately calculable in perturbative Quantum Chromodynamics (QCD) since the large mass of the b quark provides a hard scale. Therefore it is interesting to compare such predictions to results using photoproduction events where a low-virtuality photon, emitted by the incoming lepton, collides with a parton from the incoming proton. A measurement of beauty in photoproduction has been made at HERA with the ZEUS detector using an integrated luminosity of 126 pb-1. Beauty was identified in events with a muon in the final state by using the transverse momentum of the muon relative to the closest jet. Lifetime information from the silicon vertex detector was also used; the impact parameter of the muon with respect to the primary vertex was exploited to discriminate between signal and background. Cross sections for beauty production as a function of the muon and the jet variables were measured and compared to QCD predictions and to previous measurements. The data were found to be well described by the predictions from next-to-leading-order QCD. The dijet sample of beauty photoproduction events was also used to study higher-order QCD topologies. At leading order, the two jets in the event are produced back-to-back in azimuthal angle, such that Δφjj=φj1-φj2=π. Additional soft radiation causes small azimuthal decorrelations, whilst Δφjj significantly lower than π is evidence of additional hard radiation. In this thesis, the cross section versus Δφjj for beauty photoproduction and the comparison to NLO QCD predictions and Monte Carlo models are presented. (orig.)

  13. Beauty in photoproduction at HERA II with the ZEUS detector

    Energy Technology Data Exchange (ETDEWEB)

    Boutle, Sarah

    2010-02-15

    The production of beauty quarks in ep collisions should be accurately calculable in perturbative Quantum Chromodynamics (QCD) since the large mass of the b quark provides a hard scale. Therefore it is interesting to compare such predictions to results using photoproduction events where a low-virtuality photon, emitted by the incoming lepton, collides with a parton from the incoming proton. A measurement of beauty in photoproduction has been made at HERA with the ZEUS detector using an integrated luminosity of 126 pb{sup -}1. Beauty was identified in events with a muon in the final state by using the transverse momentum of the muon relative to the closest jet. Lifetime information from the silicon vertex detector was also used; the impact parameter of the muon with respect to the primary vertex was exploited to discriminate between signal and background. Cross sections for beauty production as a function of the muon and the jet variables were measured and compared to QCD predictions and to previous measurements. The data were found to be well described by the predictions from next-to-leading-order QCD. The dijet sample of beauty photoproduction events was also used to study higher-order QCD topologies. At leading order, the two jets in the event are produced back-to-back in azimuthal angle, such that {delta}{phi}{sup jj}={phi}{sup j1}-{phi}{sup j2}={pi}. Additional soft radiation causes small azimuthal decorrelations, whilst {delta}{phi}{sup jj} significantly lower than {pi} is evidence of additional hard radiation. In this thesis, the cross section versus {delta}{phi}{sup jj} for beauty photoproduction and the comparison to NLO QCD predictions and Monte Carlo models are presented. (orig.)

  14. 75 FR 10345 - Pricing for 2010 United States Mint America the Beautiful Quarters Proof Set, etc.

    Science.gov (United States)

    2010-03-05

    ... United States Mint Pricing for 2010 United States Mint America the Beautiful Quarters Proof Set, etc... is announcing the prices of the 2010 United States Mint America the Beautiful Quarters Proof Set; 2010 United States Mint America the Beautiful Quarters Silver Proof Set; 2010 United States...

  15. Beauty is as beauty does: body image and self-esteem of pageant contestants.

    Science.gov (United States)

    Thompson, S H; Hammond, K

    2003-09-01

    Self-esteem, dieting, and body image of 131 female beauty pageant contestants (mean age 26.0 years) from 43 states were examined by an anonymous survey. Most (89.6%) reported being a pageant finalist or winner and 55.2% had competed at the nationa/international level Over one-fourth (26%) of the women had been told or perceived they had an eating disorder which reportedly began at 16.25 years. Almost half (48.5%) reported wanting to be thinner and 57% were trying to lose weight. Higher self-esteem scores were significantly associated with increased level of competition (i.e.: from local to international pageants), but not with the number of times the women were pageant finalists or winners. Future study is warranted to determine how pageant participation influences self-esteem, body image, and the development of eating disorders. PMID:14649788

  16. The Therapeutic Reactance Scale: Development and Reliability.

    Science.gov (United States)

    Dowd, E. Thomas; And Others

    Much more research has been done on the effectiveness of therapeutic techniques than on the client characteristics which mediate the effectiveness of these techniques. Research on client characteristics has concentrated on demographic variables rather than psychological characteristics such as client reactance. The Therapeutic Reactance Scale was…

  17. Beauty and charm production in fixed target experiments

    International Nuclear Information System (INIS)

    We present calculations of NNLO threshold corrections for beauty and charm production in π- p and pp interactions at fixed-target experiments. Recent calculations for heavy quark hadroproduction have included next-to-next-to-leading-order (NNLO) soft-gluon corrections [1] to the double differential cross section from threshold resummation techniques [2]. These corrections are important for near-threshold beauty and charm production at fixed-target experiments, including HERA-B and some of the current and future heavy ion experiments

  18. CP violation in charm and beauty decays at LHCb

    International Nuclear Information System (INIS)

    LHCb is a dedicated heavy flavour physics precision experiment at the LHC searching for New Physics (NP) beyond the Standard Model (SM) through the study of very rare decays of beauty and charm-flavoured hadrons and precision measurements of CP-violating observables. In this review I will present a selection of recent precision measurements of CP-violating observables in the decays of beauty and charm-flavoured hadrons. These measurements are based on an integrated luminosity of up to 1.0 fb−1 collected by LHCb in 2011

  19. Beauty photoproduction using decays into electrons at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Chekanov, S.; Derrick, M.; Magill, S. [Argonne National Laboratory, Argonne, IL (US)] (and others)

    2008-05-15

    Photoproduction of beauty quarks in events with two jets and an electron associated with one of the jets has been studied with the ZEUS detector at HERA using an integrated luminosity of 120 pb{sup -1}. The fractions of events containing b quarks, and also of events containing c quarks, were extracted from a likelihood fit using variables sensitive to electron identification as well as to semileptonic decays. Total and differential cross sections for beauty and charm production were measured and compared with next-to-leading-order QCD calculations and Monte Carlo models. (orig.)

  20. CP violation in charm and beauty decays at LHCb

    Energy Technology Data Exchange (ETDEWEB)

    Pepe Altarelli, M., E-mail: monica.pepe.altarelli@cern.ch

    2013-08-15

    LHCb is a dedicated heavy flavour physics precision experiment at the LHC searching for New Physics (NP) beyond the Standard Model (SM) through the study of very rare decays of beauty and charm-flavoured hadrons and precision measurements of CP-violating observables. In this review I will present a selection of recent precision measurements of CP-violating observables in the decays of beauty and charm-flavoured hadrons. These measurements are based on an integrated luminosity of up to 1.0 fb{sup −1} collected by LHCb in 2011.

  1. Simple estimates of the hidden beauty pentaquarks masses

    CERN Document Server

    Kopeliovich, Vladimir

    2015-01-01

    The masses of cryptoexotic pentaquarks with hidden beauty are estimated phenomenologically using the results by the LHCb collaboration which discovered recently the cryptoexotic pentaquarks with hidden charm. The expected masses of the hidden beauty pentaquarks are about $10.8\\, GeV$ and $10.7\\,GeV$ in the limit of some kind of heavy quark symmetry. The states with hidden strangeness considered in similar way have masses above $2\\, Gev$, by several hundreds of $MeV$ higher than states discussed previously in connection with the relatively light positive strangeness pentaquark $\\theta^+$.

  2. Open charm and beauty production in hadron reactions

    Energy Technology Data Exchange (ETDEWEB)

    Lykasov, G.I.; Lyubushkin, V.V.; Bednyakov, V.A. [Joint Institute for Nuclear Research, 141980, Dubna, Moscow region (Russian Federation)

    2010-01-15

    The production of charmed and beauty hadrons in proton-proton and proton-antiproton collisions at high energies is analyzed within the modified quark-gluon string model (QGSM) including the internal motion of quarks in colliding hadrons. It is shown that using both the QGSM and NLO QCD one can describe these experimental data rather successfully in a wide region of transverse momenta. We also present some predictions for the future experiments on the beauty baryon production in pp collisions at LHC energies and on the charmed meson production in p-bar p reactions at GSI energies.

  3. Beauty, charm and hyperon production at fixed-target experiments

    Energy Technology Data Exchange (ETDEWEB)

    Erik Gottschalk

    2002-12-11

    Over the years fixed-target experiments have performed numerous studies of particle production in strong interactions. The experiments have been performed with different types of beam particles of varying energies, and many different target materials. Since the physics of particle production is still not understood, ongoing research of phenomena that we observe as beauty, charm and strange-particle production is crucial if we are to gain an understanding of these fundamental processes. It is in this context that recent results from fixed-target experiments on beauty, charm, and hyperon production will be reviewed.

  4. Beautiful Testing Leading Professionals Reveal How They Improve Software

    CERN Document Server

    Goucher, Adam

    2009-01-01

    Successful software depends as much on scrupulous testing as it does on solid architecture or elegant code. But testing is not a routine process, it's a constant exploration of methods and an evolution of good ideas. Beautiful Testing offers 23 essays from 27 leading testers and developers that illustrate the qualities and techniques that make testing an art. Through personal anecdotes, you'll learn how each of these professionals developed beautiful ways of testing a wide range of products -- valuable knowledge that you can apply to your own projects. Here's a sample of what you'll find i

  5. Improving competitiveness of Daisy.Queen Beauty Salon

    OpenAIRE

    Li, Yan

    2012-01-01

    The purpose of this thesis was to conduct a case study through some surveys and recommendations. The aim of the study was to find competitor‟s advantages, then it could provide recommendations and ways to Daisy.Queen beauty salon to be more attractive and competitive. The theoretical part of thesis include the importance of service, the seven P‟s of service marketing, the importance of service marketing in beauty industry. The seven P‟s of service marketing was analyzed and supported to th...

  6. Beauty production with the ZEUS HERA II data

    International Nuclear Information System (INIS)

    Beauty production has been measured with the ZEUS detector at HERA II using e+ p data collected in 2003/04. Two preliminary measurements of beauty production in events containing jets and a muon are presented. The first exploits the new ZEUS microvertex detector to measure the b content in photoproduction events by means of the muon impact parameter and its transverse momentum relative to the closest jet. The second measurement determines the b content of DIS events by using the relative transverse momentum of the muon alone. The results of both measurements were found to be in agreement with previous results and with QCD predictions. (author)

  7. The beautiful infant and Israel’s salvation

    OpenAIRE

    James A. Loader

    2011-01-01

    The motif from the Exodus story of Moses as a beautiful infant is considered on several levels. Firstly, the immediate context of Exodus 2 in the Hebrew Bible and in the Septuagint is investigated. Exodus 2 is then related to the reception of the tradition in the New Testament and Jewish sources as well as in a patristic reading and one from the Reformation. The article concludes that the motif of Moses’ beauty is part of a relatively infrequent but nevertheless well-established constellation...

  8. Online Beauty Sites Face Uncertain Future(iSyndicate News)

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    This week’s announcements that e-tailersGloss.com and Beautyscene.com are up for sale are astrong indication that online beauty products firms willbe among the early victims of the projected e-commerceshakeout.“With the plethora of beauty sites out there,it hasall come down to which few are going to survive,”saidLisa Allen,an analyst with Forrester Research.“Onlythose with strong brand presence,a solid customer baseand a bricks-and-mortar presence will be around in thelong term.”

  9. BRAND AND VISUAL IDENTITY DESIGN FOR A BEAUTY SALON

    OpenAIRE

    Borhani, Maryam

    2015-01-01

    The aim of this thesis is to create a brand and a visual identity for a beauty-salon called Narsissi. Narsissi offers a relaxing environment where both men and women can get lasting beauty treatment results. For a firm being branded is unavoidable. Everything from the look of the logo to the smoothness of service communicates something to the possible customer. In today's market, to be competitive means to be in control of the brand. A huge part of a brand's effectiveness is visual. T...

  10. Beautiful Data The Stories Behind Elegant Data Solutions

    CERN Document Server

    Segaran, Toby

    2009-01-01

    In this insightful book, you'll learn from the best data practitioners in the field just how wide-ranging -- and beautiful -- working with data can be. Join 39 contributors as they explain how they developed simple and elegant solutions on projects ranging from the Mars lander to a Radiohead video. With Beautiful Data, you will: Explore the opportunities and challenges involved in working with the vast number of datasets made available by the WebLearn how to visualize trends in urban crime, using maps and data mashupsDiscover the challenges of designing a data processing system that works wi

  11. Beauty photoproduction using decays into electrons at HERA

    International Nuclear Information System (INIS)

    Photoproduction of beauty quarks in events with two jets and an electron associated with one of the jets has been studied with the ZEUS detector at HERA using an integrated luminosity of 120 pb-1. The fractions of events containing b quarks, and also of events containing c quarks, were extracted from a likelihood fit using variables sensitive to electron identification as well as to semileptonic decays. Total and differential cross sections for beauty and charm production were measured and compared with next-to-leading-order QCD calculations and Monte Carlo models. (orig.)

  12. Charm and Beauty Production from Semileptonic Decays at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Juengst, Markus [Universitaet Bonn (Germany)

    2010-07-01

    Measurement of the photoproduction of b-quarks at threshold at HERA The cross section of bb-bar photoproduction in ep collisions is measured with the H1 detector at HERA. Events containing b-quarks are identified through detection of two low momentum electrons in the final state. Semileptonic decays bb-bar {yields} ee X are exploited in the kinematic range of the photon virtuality Q{sup 2} < 1 GeV{sup 2}, the inelasticity 0.2 < y < 0.8 and the pseudorapidity of the b-quarks |{eta}(b), {eta}(b-bar)| < 2. The differential b-quark production cross section is measured as a function of the transverse b-quark momentum and extends the previously experimentally accessible phase space towards the b-quark production threshold. The results are compared to other b-quark cross section measurements, as well as to QCD predictions. Measurement of charm and beauty production in deep inelastic ep scattering from decays into muons at HERA The production of charm and beauty quarks in ep interactions has been measured with the ZEUS detector at HERA for squared four-momentum exchange Q{sup 2}>20 GeV{sup 2}, using an integrated luminosity of 126 pb{sup -1}. Charm and beauty quarks were identified through their decays into muons. Differential cross sections were measured for muon transverse momenta p{sub T}{sup {mu}>}1.5 GeV and pseudo-rapidities -1.6<{eta}{sup {mu}<}2.3, as a function of p{sub T}{sup {mu}}, {eta}{sup {mu}}, Q{sup 2} and Bjorken x. The charm and beauty contributions to the proton structure function F{sub 2} were also extracted. The results agree with previous measurements based on independent techniques and are well described by QCD predictions. Measurement of beauty production in DIS and F2b b-bar extraction at ZEUS Beauty production in deep inelastic scattering with events in which a muon and a jet are observed in the final state has been measured with the ZEUS detector at HERA using an integrated luminosity of 114 pb{sup -1}. The fraction of events with beauty quarks

  13. Media, Construction and Deconstruction of Beauty Myth : – A Case Study of Dove’s Real Beauty Campaign

    OpenAIRE

    Zhang, Xiaohui

    2010-01-01

    The paper examines the media portrayal of real women in Dove’s Real Beauty Campaign. Through the semiotic analysis and reception analysis of the ad “Evolution”, the author investigates how Dove attempts to challenge the myth in most beauty advertising and present the “real beauty” idea to the audiences. The study further discusses about the gender issues aroused from the campaign. The findings show that the untouchable images of women are created under the pressures of male-dominated culture....

  14. Neural correlates of visual aesthetics--beauty as the coalescence of stimulus and internal state.

    Science.gov (United States)

    Jacobs, Richard H A H; Renken, Remco; Cornelissen, Frans W

    2012-01-01

    How do external stimuli and our internal state coalesce to create the distinctive aesthetic pleasures that give vibrance to human experience? Neuroaesthetics has so far focused on the neural correlates of observing beautiful stimuli compared to neutral or ugly stimuli, or on neural correlates of judging for beauty as opposed to other judgments. Our group questioned whether this approach is sufficient. In our view, a brain region that assesses beauty should show beauty-level-dependent activation during the beauty judgment task, but not during other, unrelated tasks. We therefore performed an fMRI experiment in which subjects judged visual textures for beauty, naturalness and roughness. Our focus was on finding brain activation related to the rated beauty level of the stimuli, which would take place exclusively during the beauty judgment. An initial whole-brain analysis did not reveal such interactions, yet a number of the regions showing main effects of the judgment task or the beauty level of stimuli were selectively sensitive to beauty level during the beauty task. Of the regions that were more active during beauty judgments than roughness judgments, the frontomedian cortex and the amygdala demonstrated the hypothesized interaction effect, while the posterior cingulate cortex did not. The latter region, which only showed a task effect, may play a supporting role in beauty assessments, such as attending to one's internal state rather than the external world. Most of the regions showing interaction effects of judgment and beauty level correspond to regions that have previously been implicated in aesthetics using different stimulus classes, but based on either task or beauty effects alone. The fact that we have now shown that task-stimulus interactions are also present during the aesthetic judgment of visual textures implies that these areas form a network that is specifically devoted to aesthetic assessment, irrespective of the stimulus type. PMID:22384006

  15. Neural correlates of visual aesthetics--beauty as the coalescence of stimulus and internal state.

    Directory of Open Access Journals (Sweden)

    Richard H A H Jacobs

    Full Text Available How do external stimuli and our internal state coalesce to create the distinctive aesthetic pleasures that give vibrance to human experience? Neuroaesthetics has so far focused on the neural correlates of observing beautiful stimuli compared to neutral or ugly stimuli, or on neural correlates of judging for beauty as opposed to other judgments. Our group questioned whether this approach is sufficient. In our view, a brain region that assesses beauty should show beauty-level-dependent activation during the beauty judgment task, but not during other, unrelated tasks. We therefore performed an fMRI experiment in which subjects judged visual textures for beauty, naturalness and roughness. Our focus was on finding brain activation related to the rated beauty level of the stimuli, which would take place exclusively during the beauty judgment. An initial whole-brain analysis did not reveal such interactions, yet a number of the regions showing main effects of the judgment task or the beauty level of stimuli were selectively sensitive to beauty level during the beauty task. Of the regions that were more active during beauty judgments than roughness judgments, the frontomedian cortex and the amygdala demonstrated the hypothesized interaction effect, while the posterior cingulate cortex did not. The latter region, which only showed a task effect, may play a supporting role in beauty assessments, such as attending to one's internal state rather than the external world. Most of the regions showing interaction effects of judgment and beauty level correspond to regions that have previously been implicated in aesthetics using different stimulus classes, but based on either task or beauty effects alone. The fact that we have now shown that task-stimulus interactions are also present during the aesthetic judgment of visual textures implies that these areas form a network that is specifically devoted to aesthetic assessment, irrespective of the stimulus type.

  16. Neural Correlates of Visual Aesthetics – Beauty as the Coalescence of Stimulus and Internal State

    Science.gov (United States)

    Jacobs, Richard H. A. H.; Renken, Remco; Cornelissen, Frans W.

    2012-01-01

    How do external stimuli and our internal state coalesce to create the distinctive aesthetic pleasures that give vibrance to human experience? Neuroaesthetics has so far focused on the neural correlates of observing beautiful stimuli compared to neutral or ugly stimuli, or on neural correlates of judging for beauty as opposed to other judgments. Our group questioned whether this approach is sufficient. In our view, a brain region that assesses beauty should show beauty-level-dependent activation during the beauty judgment task, but not during other, unrelated tasks. We therefore performed an fMRI experiment in which subjects judged visual textures for beauty, naturalness and roughness. Our focus was on finding brain activation related to the rated beauty level of the stimuli, which would take place exclusively during the beauty judgment. An initial whole-brain analysis did not reveal such interactions, yet a number of the regions showing main effects of the judgment task or the beauty level of stimuli were selectively sensitive to beauty level during the beauty task. Of the regions that were more active during beauty judgments than roughness judgments, the frontomedian cortex and the amygdala demonstrated the hypothesized interaction effect, while the posterior cingulate cortex did not. The latter region, which only showed a task effect, may play a supporting role in beauty assessments, such as attending to one's internal state rather than the external world. Most of the regions showing interaction effects of judgment and beauty level correspond to regions that have previously been implicated in aesthetics using different stimulus classes, but based on either task or beauty effects alone. The fact that we have now shown that task-stimulus interactions are also present during the aesthetic judgment of visual textures implies that these areas form a network that is specifically devoted to aesthetic assessment, irrespective of the stimulus type. PMID:22384006

  17. Masses and couplings of open beauty states in QCD

    International Nuclear Information System (INIS)

    Masses and couplings of open beauty states (strange and non-strange) with Jsup(PC) = 0++, 0-+, 1--. and 1++ are calculated using the QCD sum rule formalism. Non-perturbative effects due to quark and gluon condensate operators are shown to be important, confirming earlier calculations for equal quark mass systems. (author)

  18. Beauty vector meson decay constants from QCD sum rules

    International Nuclear Information System (INIS)

    We present the outcomes of a very recent investigation of the decay constants of nonstrange and strange heavy-light beauty vector mesons, with special emphasis on the ratio of any such decay constant to the decay constant of the corresponding pseudoscalar meson, by means of Borel-transformed QCD sum rules. Our results suggest that both these ratios are below unity

  19. A hyperactive sleeping beauty transposase enhances transgenesis in zebrafish embryos

    Directory of Open Access Journals (Sweden)

    Lardelli Michael

    2010-11-01

    Full Text Available Abstract Background Transposons are useful molecular tools for transgenesis. The 'sleeping beauty' transposon is a synthetic member of the Tc1/mariner transposon family. Davidson et al. (2003 previously described a vector for zebrafish transgenesis consisting of the inverted repeats of 'sleeping beauty' flanking the gene to be transposed. Subsequently, there have been attempts to enhance the transpositional activity of 'sleeping beauty' by increasing the activity of its transposase. Recently, Mates et al. (2009 generated a hyperactive transposase giving a 100-fold increased transposition rate in mouse embryos. Findings The aim of this experiment was to determine whether this novel hyperactive transposase enhances transgenesis in zebrafish embryos. Using our previously characterised mitfa-amyloidβ-GFP transgene, we observed an eight-fold enhancement in transient transgenesis following detection of transgene expression in melanophores by whole mount in-situ hybridisation. However, high rates of defective embryogenesis were also observed. Conclusion The novel hyperactive 'sleeping beauty' transposase enhances the rate of transgenesis in zebrafish embryos.

  20. Beauty Vector Meson Decay Constants from QCD Sum Rules

    CERN Document Server

    Lucha, Wolfgang; Simula, Silvano

    2016-01-01

    We present the outcomes of a very recent investigation of the decay constants of nonstrange and strange heavy-light beauty vector mesons, with special emphasis on the ratio of any such decay constant to the decay constant of the corresponding pseudoscalar meson, by means of Borel-transformed QCD sum rules. Our results suggest that both these ratios are below unity.

  1. Beauty vector meson decay constants from QCD sum rules

    Science.gov (United States)

    Lucha, Wolfgang; Melikhov, Dmitri; Simula, Silvano

    2016-01-01

    We present the outcomes of a very recent investigation of the decay constants of nonstrange and strange heavy-light beauty vector mesons, with special emphasis on the ratio of any such decay constant to the decay constant of the corresponding pseudoscalar meson, by means of Borel-transformed QCD sum rules. Our results suggest that both these ratios are below unity.

  2. Beauty vector meson decay constants from QCD sum rules

    Energy Technology Data Exchange (ETDEWEB)

    Lucha, Wolfgang [Institute for High Energy Physics, Austrian Academy of Sciences, Nikolsdorfergasse 18, A-1050 Vienna (Austria); Melikhov, Dmitri [Institute for High Energy Physics, Austrian Academy of Sciences, Nikolsdorfergasse 18, A-1050 Vienna (Austria); D. V. Skobeltsyn Institute of Nuclear Physics, M. V. Lomonosov Moscow State University, 119991, Moscow (Russian Federation); Simula, Silvano [Istituto Nazionale di Fisica Nucleare, Sezione di Roma Tre, Via della Vasca Navale 84, I-00146, Roma (Italy)

    2016-01-22

    We present the outcomes of a very recent investigation of the decay constants of nonstrange and strange heavy-light beauty vector mesons, with special emphasis on the ratio of any such decay constant to the decay constant of the corresponding pseudoscalar meson, by means of Borel-transformed QCD sum rules. Our results suggest that both these ratios are below unity.

  3. The use of emulsions from the π meson to beauty

    International Nuclear Information System (INIS)

    A description is given of the contributions of the emulsion technique to particle physics in the accelerator age. These include determinations of particle properties, hypernuclear physics and more recently charm and beauty searches with hybrid detectors in which emulsion stacks form the high spatial resolution vertex detectors. (author)

  4. The "F" Word: Is Feminism Incompatible with Beauty and Romance?

    Science.gov (United States)

    Rudman, Laurie A.; Fairchild, Kimberly

    2007-01-01

    Three studies examined the predictive utility of heterosexual relationship concerns vis-a-vis support for feminism. Study 1 showed that beauty is perceived to be at odds with feminism, for both genders. The stereotype that feminists are unattractive was robust, but fully accounted for by romance-related attributions. Moreover, more attractive…

  5. Jie Chen—The beauty in Her Study

    Institute of Scientific and Technical Information of China (English)

    Willow

    2004-01-01

    Reading,wriing and watching movies,are ddefined as"activities in her study"by Jie Chen,a beautiful writer,editor,and film riviewer,well known mationwide.As one of the liading representatives of essay creation in China,Jie Chen started her career as a uourmalist in Chengdu Evening.After her successful

  6. Mases and coupling of open beauty states in QCD

    International Nuclear Information System (INIS)

    Masses and couplings of open beauty states (strange and non-strange) with Jsup(P)sup(C) = 0++, 0-+, 1--, and 1++ are calculated using the QCD sum rule formalism. Non-perturbative effects due to quark and gluon condensate operators are shown to be important, confirming earlier calculations for equal quark mass systems. (orig.)

  7. Cosmetology Curriculum and Training as Seen by Beauty Salons.

    Science.gov (United States)

    San Mateo Coll., CA.

    To evaluate the effectiveness of its cosmetology program, the College of San Mateo sent a questionnaire to beauty salons in the college's service area. Of the 70 questionnaires sent, over half were returned. Eleven courses in the curriculum were ranked by the employer in order of importance to him, the first four being the 1,600 hours of…

  8. Asymmetry and Symmetry in the Beauty of Human Faces

    Directory of Open Access Journals (Sweden)

    Marjan Hessamian

    2010-02-01

    Full Text Available The emphasis in the published literature has mostly been on symmetry as the critical source for beauty judgment. In fact, both symmetry and asymmetry serve as highly aesthetic sources of beauty, whether the context is perceptual or conceptual. The human brain is characterized by symbolic cognition and this type of cognition facilitates a range of aesthetic reactions. For example, both art and natural scenery contain asymmetrical elements, which nevertheless render the whole effect beautiful. A further good case in point is, in fact, human faces. Normally, faces are structurally left-right symmetrical content-wise but not size-wise or function-wise. Attractiveness has often been discussed in terms of content-wise full-face symmetry. To test whether or not attractiveness can be gleaned only from the presence of left-right full-faces we tested half faces. Three separate groups of participants viewed and rated the attractiveness of 56 full-faces (women’s and men’s, their 56 vertical left hemi-faces and 56 vertical right hemi-faces. We found no statistically significant differences in the attractiveness ratings of full- and hemi-faces (whether left or right. Instead, we found a strong and significant positive correlation between the ratings of the hemi- and full-faces. These results are consistent with the view that the underpinning of human facial beauty is complex and that bilateral symmetry does not constitute a principle factor in beauty assessment. We discuss that the highly evolved human brain, compared to other animals, as well as symbolic and abstract cognition in humans enable a wide variety of aesthetic reactions.

  9. Measurement of beauty and charm production in deep inelastic scattering at HERA and measurement of the beauty-quark mass

    Energy Technology Data Exchange (ETDEWEB)

    Abramowicz, H. [Tel Aviv Univ. (Israel). School of Physics; Max Planck Institute for Physics, Munich (Germany); Abt, I. [Max Planck Institute for Physics, Munich (Germany); Adamczyk, L. [AGH-Univ. of Science and Technology, Krakow (Poland). Faculty of Physics and Applied Computer Science; Collaboration: ZEUS Collaboration; and others

    2014-05-15

    The production of beauty and charm quarks in ep interactions has been studied with the ZEUS detector at HERA for exchanged four-momentum squared 5beauty and charm content in events with at least one jet have been extracted using the invariant mass of charged tracks associated with secondary vertices and the decay-length significance of these vertices. Differential cross sections as a function of Q{sup 2}, Bjorken x, jet transverse energy and pseudorapidity were measured and compared with next-to-leading-order QCD calculations. The beauty and charm contributions to the proton structure functions were extracted from the double-differential cross section as a function of x and Q{sup 2}. The running beauty-quark mass, m{sub b} at the scale m{sub b}, was determined from a QCD fit at next-to-leading order to HERA data for the first time and found to be m{sub b}(m{sub b})=4.07±0.14(fit){sup +0.01}{sub -0.07} (mod.){sup +0.05}{sub -0.00}(param.){sup +0.08}{sub -0.05}(theo) GeV.

  10. Measurement of beauty and charm production in deep inelastic scattering at HERA and measurement of the beauty-quark mass

    International Nuclear Information System (INIS)

    The production of beauty and charm quarks in ep interactions has been studied with the ZEUS detector at HERA for exchanged four-momentum squared 522 using an integrated luminosity of 354 pb-1. The beauty and charm content in events with at least one jet have been extracted using the invariant mass of charged tracks associated with secondary vertices and the decay-length significance of these vertices. Differential cross sections as a function of Q2, Bjorken x, jet transverse energy and pseudorapidity were measured and compared with next-to-leading-order QCD calculations. The beauty and charm contributions to the proton structure functions were extracted from the double-differential cross section as a function of x and Q2. The running beauty-quark mass, mb at the scale mb, was determined from a QCD fit at next-to-leading order to HERA data for the first time and found to be mb(mb)=4.07±0.14(fit)+0.01-0.07 (mod.)+0.05-0.00(param.)+0.08-0.05(theo) GeV.

  11. Measurement of beauty and charm production in deep inelastic scattering at HERA and measurement of the beauty-quark mass

    CERN Document Server

    Abramowicz, H; Adamczyk, L.; Adamus, M.; Aggarwal, R.; Antonelli, S.; Arslan, O.; Aushev, V.; Aushev, Y.; Bachynska, O.; Barakbaev, A.N.; Bartosik, N.; Behnke, O.; Behr, J.; Behrens, U.; Bertolin, A.; Bhadra, S.; Bloch, I.; Bokhonov, V.; Boos, E.G.; Borras, K.; Brock, I.; Brugnera, R.; Bruni, A.; Brzozowska, B.; Bussey, P.J.; Caldwell, A.; Capua, M.; Catterall, C.D.; Chwastowski, J.; Ciborowski, J.; Ciesielski, R.; Cooper-Sarkar, A.M.; Corradi, M.; Corriveau, F.; D'Agostini, G.; Dementiev, R.K.; Devenish, R.C.E.; Dolinska, G.; Drugakov, V.; Dusini, S.; Ferrando, J.; Figiel, J.; Foster, B.; Gach, G.; Garfagnini, A.; Geiser, A.; Gizhko, A.; Gladilin, L.K.; Gogota, O.; Golubkov, Yu. A.; Grebenyuk, J.; Gregor, I.; Grzelak, G.; Gueta, O.; Guzik, M.; Hain, W.; Hartner, G.; Hochman, D.; Hori, R.; Ibrahim, Z.A.; Iga, Y.; Ishitsuka, M.; Iudin, A.; Januschek, F.; Kadenko, I.; Kananov, S.; Kanno, T.; Karshon, U.; Kaur, M.; Kaur, P.; Khein, L.A.; Kisielewska, D.; Klanner, R.; Klein, U.; Kondrashova, N.; Kononenko, O.; Korol, Ie.; Korzhavina, I.A.; Kotanski, A.; Kotz, U.; Kovalchuk, N.; Kowalski, H.; Kuprash, O.; Kuze, M.; Levchenko, B.B.; Levy, A.; Libov, V.; Limentani, S.; Lisovyi, M.; Lobodzinska, E.; Lohmann, W.; Lohr, B.; Lohrmann, E.; Longhin, A.; Lontkovskyi, D.; Lukina, O.Yu.; Maeda, J.; Makarenko, I.; Malka, J.; Martin, J.F.; Mergelmeyer, S.; Idris, F.Mohamad; Mujkic, K.; Myronenko, V.; Nagano, K.; Nigro, A.; Nobe, T.; Notz, D.; Nowak, R.J.; Olkiewicz, K.; Onishchuk, Yu.; Paul, E.; Perlanski, W.; Perrey, H.; Pokrovskiy, N.S.; Proskuryakov, A.S.; Przybycien, M.; Raval, A.; Roloff, P.; Rubinsky, I.; Ruspa, M.; Samojlov, V.; Saxon, D.H.; Schioppa, M.; Schmidke, W.B.; Schneekloth, U.; Schorner-Sadenius, T.; Schwartz, J.; Shcheglova, L.M.; Shehzadi, R.; Shevchenko, R.; Shkola, O.; Singh, I.; Skillicorn, I.O.; Slominski, W.; Sola, V.; Solano, A.; Spiridonov, A.; Stanco, L.; Stefaniuk, N.; Stern, A.; Stewart, T.P.; Stopa, P.; Sztuk-Dambietz, J.; Szuba, D.; Szuba, J.; Tassi, E.; Temiraliev, T.; Tokushuku, K.; Tomaszewska, J.; Trofymov, A.; Trusov, V.; Tsurugai, T.; Turcato, M.; Turkot, O.; Tymieniecka, T.; Verbytskyi, A.; Viazlo, O.; Walczak, R.; Wan Abdullah, W.A.T.; Wichmann, K.; Wing, M.; Wolf, G.; Yamada, S.; Yamazaki, Y.; Zakharchuk, N.; Zarnecki, A.F.; Zawiejski, L.; Zenaiev, O.; Zhautykov, B.O.; Zhmak, N.; Zotkin, D.S.

    2014-01-01

    The production of beauty and charm quarks in ep interactions has been studied with the ZEUS detector at HERA for exchanged four-momentum squared 5 < Q^2 < 1000 GeV^2 using an integrated luminosity of 354 pb^{-1}. The beauty and charm content in events with at least one jet have been extracted using the invariant mass of charged tracks associated with secondary vertices and the decay-length significance of these vertices. Differential cross sections as a function of Q^2, Bjorken x, jet transverse energy and pseudorapidity were measured and compared with next-to-leading-order QCD calculations. The beauty and charm contributions to the proton structure functions were extracted from the double-differential cross section as a function of x and Q^2. The running beauty-quark mass, m_b at the scale m_b, was determined from a QCD fit at next-to-leading order to HERA data for the first time and found to be 4.07 \\pm 0.14 (fit} ^{+0.01}_{-0.07} (mod.) ^{+0.05}_{-0.00} (param.) ^{+0.08}_{-0.05} (theo) GeV.

  12. Therapeutics aspects of music education

    OpenAIRE

    Pesek, Albinca; Čagran, Branka

    2015-01-01

    Disintegration of moral value system in modern society demands changes of educational system. Education takes an important part with its effort to establish integral education. In this way, an individual develops all his potentials: physical, emotional, cognitive and mental. Music education in its therapeutic mission helps at forming harmonious personality and becomes a mediator at different activities where discrepancies do not allow a successful educational process. On the basis of the empi...

  13. AMUM LECTURE: Therapeutic ultrasound

    Science.gov (United States)

    Crum, Lawrence A.

    2004-01-01

    The use of ultrasound in medicine is now quite commonplace, especially with the recent introduction of small, portable and relatively inexpensive, hand-held diagnostic imaging devices. Moreover, ultrasound has expanded beyond the imaging realm, with methods and applications extending to novel therapeutic and surgical uses. These applications broadly include: tissue ablation, acoustocautery, lipoplasty, site-specific and ultrasound mediated drug activity, extracorporeal lithotripsy, and the enhancement of natural physiological functions such as wound healing and tissue regeneration. A particularly attractive aspect of this technology is that diagnostic and therapeutic systems can be combined to produce totally non-invasive, imageguided therapy. This general lecture will review a number of these exciting new applications of ultrasound and address some of the basic scientific questions and future challenges in developing these methods and technologies for general use in our society. We shall particularly emphasize the use of High Intensity Focused Ultrasound (HIFU) in the treatment of benign and malignant tumors as well as the introduction of acoustic hemostasis, especially in organs which are difficult to treat using conventional medical and surgical techniques.

  14. Estrogen formulations and beauty care practices in Japanese women

    Directory of Open Access Journals (Sweden)

    Takeda T

    2012-01-01

    Full Text Available Takashi Takeda, Tze Fang Wong, Mari Kitamura, Nobuo YaegashiDepartment of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Miyagi, JapanPurpose: Traditionally, oral estrogens have been used for hormone replacement therapy. However, in Japan, additional estrogen formulations have been used, including transdermal patches and transdermal gels. The latter have a unique commonality with cosmetics because both of them are applied to the skin. Beauty care is one of the most important lifestyle factors for women, and it has been reported that the amount of attention paid to beauty care has an effect in determining whether or not women will choose to undergo HRT during menopause. Therefore, our study focused on estrogen formulations and beauty care practices.Patients and methods: Fifty women who use hormone replacement therapy were recruited from the outpatient clinic of Tohoku University Hospital. They were treated with oral conjugated estrogen (n = 11, transdermal 17ß -estradiol patch (n = 11, and transdermal 17ß-estradiol gel (n = 28. They completed a questionnaire to assess their lifestyle (beauty care practices and exercise habits and their compliance. The transdermal gel users were further interviewed about their subjective impressions regarding “smell”, “sticky feeling”, “spreadability”, and “irritation” on the skin using a five-grade scale.Results: There were no differences in the usability of medicines and patient compliance among the estrogen formulations. We observed a positive tendency between the level of beauty care and transdermal gel use (P = 0.0645, ordinary logistic regression analysis. The gel users placed top priority on a lack of “sticky feeling” but the subjective impression regarding “sticky feeling” was worst among the four factors (P < 0.01, Steel–Dwass test. Correspondence analysis showed that the subjective impressions of transdermal gel corresponding to usability in the

  15. A study of beauty and charm muoproduction at the SPS

    International Nuclear Information System (INIS)

    We propose an experiment to study beauty and charm muoproduction via semi-leptonic decays into multi-muon final states. The apparatus for the experiment is based on the EMC Forward Spectrometer (NA2) with a factor proportional 500 increase in luminosity. The measurements proposed include the study of upsilon and B-anti B production and will provide for a much improved experimental limit on the amount of D0 - anti D0 mixing. From a comparison of the charm decays into 2 and 3-muon final states it is proposed to make a direct measurement of the intrinsic charm content of the nucleon. We also comment on possible studies of rare charm and beauty decays into multi-muon final states. (orig.)

  16. Perceived beauty of random texture patterns: A preference for complexity.

    Science.gov (United States)

    Friedenberg, Jay; Liby, Bruce

    2016-07-01

    We report two experiments on the perceived aesthetic quality of random density texture patterns. In each experiment a square grid was filled with a progressively larger number of elements. Grid size in Experiment 1 was 10×10 with elements added to create a variety of textures ranging from 10%-100% fill levels. Participants rated the beauty of the patterns. Average judgments across all observers showed an inverted U-shaped function that peaked near middle densities. In Experiment 2 grid size was increased to 15×15 to see if observers preferred patterns with a fixed density or a fixed number of elements. The results of the second experiment were nearly identical to that of the first showing a preference for density over fixed element number. Ratings in both studies correlated positively with a GIF compression metric of complexity and with edge length. Within the range of stimuli used, observers judge more complex patterns to be more beautiful. PMID:27155800

  17. Physics analysis tools for beauty physics in ATLAS

    Energy Technology Data Exchange (ETDEWEB)

    Anastopoulos, C [Physics Department, Aristotle University Of Thessaloniki (Greece); Bouhova-Thacker, E; Catmore, J; Mora, L de [Department of Physics, Lancaster University (United Kingdom); Dallison, S [Particle Physics Department, CCLRC Rutherford Appleton Laboratory (United Kingdom); Derue, F [LPNHE, IN2P3 - CNRS - Universites Paris VI et Paris VII (France); Epp, B; Jussel, P [Institute for Astro- and Particle Physics, University of Innsbruck (Austria); Kaczmarska, A [Institute of Nuclear Physics, Polish Academy of Sciences (Poland); Radziewski, H v; Stahl, T [Department of Physics, University of Siegen (Germany); Reznicek, P [IPNP, Faculty of Mathematics and Physics, Charles University in Prague (Czech Republic)], E-mail: pavel.reznicek@cern.ch

    2008-07-15

    The Large Hadron Collider experiments will search for physics phenomena beyond the Standard Model. Highly sensitive tests of beauty hadrons will represent an alternative approach to this research. The analysis of complex decay chains of the beauty hadrons have to efficiently extract the detector tracks made by these reactions and reject other events in order to make sufficiently precise measurement. This places severe demands on the software used to analyze the B-physics data. The ATLAS B-physics group has written a series of tools and algorithms for performing these tasks, to be run within the ATLAS offline software framework Athena. This paper describes this analysis suite, paying particular attention to mechanisms for handling combinatorics, interfaces to secondary vertex fitting packages, B-flavor tagging tools and finally Monte Carlo true information association to pursue simulation data in process of the software validations which is an important part of the development of the physics analysis tools.

  18. Penta-quark States with Strangeness, Hidden Charm and Beauty

    CERN Document Server

    Wu, Jia-Jun

    2015-01-01

    The classical quenched quark models with three constituent quarks provide a good description for the baryon spatial ground states, but fail to reproduce the spectrum of baryon excited states. More and more evidences suggest that unquenched effects with multi-quark dynamics are necessary ingredients to solve the problem. Several new hyperon resonances reported recently could fit in the picture of penta-quark states. Based on this picture, some new hyperon excited states were predicted to exist; meanwhile with extension from strangeness to charm and beauty, super-heavy narrow $N^*$ and $\\Lambda^*$ resonances with hidden charm or beauty were predicted to be around 4.3 and 11 GeV, respectively. Recently, two of such $N^*$ with hidden charm might have been observed by the LHCb experiment. More of those states are expected to be observed in near future. This opens a new window in order to study hadronic dynamics for the multi-quark states.

  19. Penta-Quark States with Strangeness, Hidden Charm and Beauty

    Science.gov (United States)

    Wu, Jia-Jun; Zou, Bing-Song

    The classical quenched quark models with three constituent quarks provide a good description for the baryon spatial ground states, but fail to reproduce the spectrum of baryon excited states. More and more evidences suggest that unquenched effects with multi-quark dynamics are necessary ingredients to solve the problem. Several new hyperon resonances reported recently could fit in the picture of penta-quark states. Based on this picture, some new hyperon excited states were predicted to exist; meanwhile with extension from strangeness to charm and beauty, super-heavy narrow N* and Λ* resonances with hidden charm or beauty were predicted to be around 4.3 and 11 GeV, respectively. Recently, two of such N* with hidden charm might have been observed by the LHCb experiment. More of those states are expected to be observed in near future. This opens a new window in order to study hadronic dynamics for the multi-quark states.

  20. Hidden-Beauty Charged Tetraquarks and Heavy Quark Spin Conservation

    CERN Document Server

    Ali, A; Polosa, A D; Riquer, V

    2014-01-01

    Assuming the dominance of the spin-spin interaction in a diquark, we point out that the mass differences in the beauty sector M(Z_b') - M(Z_b) scale with quark masses as expected in QCD, with respect to the corresponding mass difference M(Z_c') - M(Z_c). Notably, we show that the decays Upsilon(10890) --> (h_b(1P), h_b(2P)) pi pi are compatible with heavy-quark spin conservation once the contributions of Z_b,Z_b' intermediate states are taken into account, Upsilon(10890) being either a Upsilon(5S) or the beauty analog of Y_c(4260).

  1. Measurement of charm and beauty dijet cross sections in photoproduction

    International Nuclear Information System (INIS)

    A measurement of charm and beauty dijet photoproduction cross sections at the ep collider HERA is presented. The positron data of the years 1999 and 2000 are analysed, corresponding to an integrated luminosity of 56.8 pb-1. Events are selected with two or more jets of transverse momentum ptjet1(2)>11(8) GeV in the central range of pseudo-rapidity -0.9jet1(2)γobs. Taking into account the theoretical uncertainties, the charm cross sections are consistent with a QCD calculation in next-to-leading order, while the predicted cross sections for beauty production are somewhat lower than the measurement. (orig.)

  2. Hierarchy of lifetimes of charmed and beautiful hadrons

    International Nuclear Information System (INIS)

    Pre-asymptotic corrections to total hadronic widths of weak decays of charmed and beautiful hadrons are considered. The main emphasis is put on effects due to the spectator quark. The so called hybrid logarithms emerging from the domain of momenta R-2 2 Q2 (R is the hadronic size, mQ is the heavy quark mass) are taken into account, a new element of the analysis. For chamed hadrons the pre-asymptotic corrections are of order unity, and the corresponding estimates of non leptonic widths are of semiquantitative character. The hierarchy of hadronic widths for D, F mesons and Λc, Ξc(A), Ωc baryons is establish. The lifetime of Ωc0 turns out to be the smallest. The difference in lifetimes of beautiful hadrons is predicted to be definitely less than a few percent

  3. Estrogen formulations and beauty care practices in Japanese women

    OpenAIRE

    Takeda T; Wong TF; Kitamura M; Yaegashi N

    2012-01-01

    Takashi Takeda, Tze Fang Wong, Mari Kitamura, Nobuo YaegashiDepartment of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Miyagi, JapanPurpose: Traditionally, oral estrogens have been used for hormone replacement therapy. However, in Japan, additional estrogen formulations have been used, including transdermal patches and transdermal gels. The latter have a unique commonality with cosmetics because both of them are applied to the skin. Beauty care is one of the most ...

  4. Enhancer trapping in zebrafish using the Sleeping Beauty transposon

    OpenAIRE

    Welle Zachary; Hermanson Spencer B; Sivasubbu Sridhar; Davidson Ann E; Balciunas Darius; Ekker Stephen C

    2004-01-01

    Abstract Background Among functional elements of a metazoan gene, enhancers are particularly difficult to find and annotate. Pioneering experiments in Drosophila have demonstrated the value of enhancer "trapping" using an invertebrate to address this functional genomics problem. Results We modulated a Sleeping Beauty transposon-based transgenesis cassette to establish an enhancer trapping technique for use in a vertebrate model system, zebrafish Danio rerio. We established 9 lines of zebrafis...

  5. BURBERRY BEAUTY2012秋冬妆容

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    BURBERRY BEAUTY2012秋冬系列以大热裸妆为主,作为全球奢华底妆专家,不但为底妆家族推出了众所期待的新成员BURBERRY明亮丝滑遮瑕笔,同时为限部及唇部产品加入全新色系。

  6. A study of strange-, charmed, and beauty nuclei

    International Nuclear Information System (INIS)

    An analyses is made of the bound states of nuclei in the strange-, charm-, and beauty sector using a spin-dependent Gaussian two-body interaction in the microscopic formalism. Coulomb corrections are also included for the charmed nuclei. Our simple model is in reasonable agreement with other existing theoretical and experimental results and it predicts many new bound states. (author). 21 refs, 2 figs, 10 tabs

  7. Beauty and charm production from Fermilab experiment 789

    International Nuclear Information System (INIS)

    Experiment 789 is a fixed-target experiment at Fermilab designed to study low-multiplicity decays of charm and beauty. During the 1991 run. E789 collected ∼ 109 events using an 800 GeV proton beam incident upon gold and beryllium targets. Analyses of these data include searches for b → J/ψ+Χ decays and Α- dependence measurements of neutral D meson production. Preliminary results from the 1991 run are presented in this paper

  8. Hadron spectroscopy from strangeness to charm and beauty

    International Nuclear Information System (INIS)

    Quarks of different flavors have different masses, which will cause breaking of flavor symmetries of QCD. Flavor symmetries and their breaking in hadron spectroscopy play important role for understanding the internal structures of hadrons. Hadron spectroscopy with strangeness reveals the importance of unquenched quark dynamics. Systematic study of hadron spectroscopy with strange, charm and beauty quarks would be very revealing and essential for understanding the internal structure of hadrons and its underlying quark dynamics

  9. Hadron spectroscopy from strangeness to charm and beauty

    Energy Technology Data Exchange (ETDEWEB)

    Zou, B.S., E-mail: zoubs@ihep.ac.cn [State Key Laboratory of Theoretical Physics, Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 100190 (China); Institute of High Energy Physics and Theoretical Physics Center for Science Facilities, Chinese Academy of Sciences, Beijing 100049 (China)

    2013-09-20

    Quarks of different flavors have different masses, which will cause breaking of flavor symmetries of QCD. Flavor symmetries and their breaking in hadron spectroscopy play important role for understanding the internal structures of hadrons. Hadron spectroscopy with strangeness reveals the importance of unquenched quark dynamics. Systematic study of hadron spectroscopy with strange, charm and beauty quarks would be very revealing and essential for understanding the internal structure of hadrons and its underlying quark dynamics.

  10. Spectroscopy of onia and hadrons with open beauty in ATLAS

    CERN Document Server

    Henderson, RCW; The ATLAS collaboration

    2015-01-01

    Results published by the ATLAS experiment at the LHC are presented. The ATLAS discovery of the $\\chi_b(3P)$ onia state is recalled and report the new observation of an excited open beauty hadronic state, a $B_c^{\\pm}$ meson with mass $6842 \\pm 4(stat) \\pm 5(syst)$ MeV consistent with expectations for the $B_c^{\\pm}(2S)$.

  11. Recurrent encephalopathy? No I’m a sleeping beauty!

    OpenAIRE

    Mehtab Iqbal; Manish Prasad; Christopher Ritey

    2014-01-01

    To describe the clinical presentation of ′Kleine-Levin (sleeping beauty) syndrome′ in a child, who presented with recurrent episodes consistent with encephalopathy, associated with excessive sleepiness, cognitive and behavioural disturbance and hyper sexuality. 14 years old boy presented acutely with excessive tiredness, sleeping excessively, abnormal behaviour and hypersexuality following a viral throat infection. On examination he was sleepy but easily arousable. His GCS (15/15) and rest of...

  12. Beautiful Teams Inspiring and Cautionary Tales from Veteran Team Leaders

    CERN Document Server

    Stellman, Andrew

    2009-01-01

    What's it like to work on a great software development team facing an impossible problem? How do you build an effective team? Beautiful Teams takes you behind the scenes with some of the most interesting teams in software engineering history. You'll learn from veteran team leaders' successes and failures, told through a series of engaging personal stories -- and interviews -- by leading programmers, architects, project managers, and thought leaders.

  13. Penta-quark states with hidden charm and beauty

    CERN Document Server

    Zou, Bing-Song

    2011-01-01

    More and more hadron states are found to be difficult to be accommodated by the quenched quark models which describe baryons as 3-quark states and mesons as antiquark-quark states. Dragging out an antiquark-quark pair from the gluon field in hadrons should be an important excitation mechanism for hadron spectroscopy. Our recent progress on the penta-quark states with hidden charm and beauty is reviewed.

  14. On charm and beauty decays: A theorist's perspective

    International Nuclear Information System (INIS)

    The present understanding of charm and bottom decays is reviewed. Special emphasis is placed on discussing the theoretical uncertainties in view of the particularly rich harvest of new data from the last year. A semi-quantitative description of D decays has emerged enabling us to address rather detailed and relatively subtle questions there, like on once and twice Cabibbo suppressed decays. Beauty physics having left its infancy is now in its adolescence; its future development towards maturity is analyzed

  15. Feminist guilt or the ambivalency of feminism towards beauty practices

    OpenAIRE

    Otorepec, Klara

    2015-01-01

    The purpose of this thesis is to research different factors that help shape and form the concept of feminist guilt. This is how I name the discomfort that occurs as a response to difficulties in exercising feminist principles in daily life in relation to (non)practising beauty practices or as a dichotomy between feminist ideology and patriarchal social order. The theoretical focus explores how the pressure of normative femininity as a Foucauldian disciplinary project of contemporary society, ...

  16. The Beauty Contest and Short-Term Trading

    OpenAIRE

    Giovanni Cespa; Xavier Vives

    2014-01-01

    Short-termism need not breed informational price inefficiency even when generating Beauty Contests. We demonstrate this claim in a two-period market with persistent liquidity trading and risk-averse, privately informed, short-term investors and find that prices reect average expectations about fundamentals and liquidity trading. Informed investors engage in "retrospective" learning to reassess inferences (about fundamentals) made during the trading game's early stages. This behavior introduce...

  17. Hadron spectroscopy from strangeness to charm and beauty

    Science.gov (United States)

    Zou, B. S.

    2013-09-01

    Quarks of different flavors have different masses, which will cause breaking of flavor symmetries of QCD. Flavor symmetries and their breaking in hadron spectroscopy play important role for understanding the internal structures of hadrons. Hadron spectroscopy with strangeness reveals the importance of unquenched quark dynamics. Systematic study of hadron spectroscopy with strange, charm and beauty quarks would be very revealing and essential for understanding the internal structure of hadrons and its underlying quark dynamics.

  18. Thailand, A beauty hub for everyone? : Internationalizing Thai Aesthetic Surgery

    OpenAIRE

    Sinhaneti, Kantara; Pullawan, Jitmanee

    2008-01-01

    Introduction: Aesthetic surgery becomes another option of beauty. Interested Patients seeking for choices offered outside their homeland for more benefits. Thailand maybe one of those choices people is now interested in. Thai aesthetic industry may prove to be one of the most wanted destinations because of its expertise and relatively low cost with impressive service. Problem: “How should Thailand improve its Aesthetic service attractiveness to drive its potential to the level of internationa...

  19. The "Beautiful" pain: cosmetic surgery and the embodiment of pain

    OpenAIRE

    Alexias, George; Dilaki, Georgija; Tsekeris, Charalambos

    2012-01-01

    This article focuses on women undergoing plastic surgery operations, highlighting their particular attitude toward pain, which is caused by the desperate pursuit of beauty. Extracting data from semi-structured interviews, it is shown how pain is defied, eliminated or even denied by individuals undergoing cosmetic surgery. Since cosmetic procedures are carried out for aesthetic reasons, people disconnect this process from any negative emotion and ignore pain and trauma yielded from surgical op...

  20. BEAUTY, HEALTH AND WELL-BEING WITH COSMETOTEXTILES

    OpenAIRE

    CRETU Viorica

    2014-01-01

    The concept of cosmetotextiles, as another aspect of new beauty and health marques a growing success. This hybrid fabric, is definite as a textile article that contains a substance that is release sustainable on the human body skin pointed to perfume, change of appearance, maintenance in good condition, protection, or correction of body odors. Cosmetotextiles are created by microencapsulating different substances for body care or health, that are gradually transfer to the skin, by movement...

  1. Consensus on Changing Trends, Attitudes, and Concepts of Asian Beauty

    OpenAIRE

    Liew, Steven; Wu, Woffles T. L.; Chan, Henry H.; Ho, Wilson W. S.; Kim, Hee-Jin; Goodman, Greg J; Peng, Peter H. L.; Rogers, John D.

    2015-01-01

    Background Asians increasingly seek non-surgical facial esthetic treatments, especially at younger ages. Published recommendations and clinical evidence mostly reference Western populations, but Asians differ from them in terms of attitudes to beauty, structural facial anatomy, and signs and rates of aging. A thorough knowledge of the key esthetic concerns and requirements for the Asian face is required to strategize appropriate facial esthetic treatments with botulinum toxin and hyaluronic a...

  2. Measurement of open beauty production in photoproduction at HERA

    CERN Document Server

    Breitweg, J; Derrick, Malcolm; Krakauer, D A; Magill, S; Musgrave, B; Pellegrino, A; Repond, J; Stanek, R; Yoshida, R; Mattingly, M C K; Antonioli, P; Bari, G; Basile, M; Bellagamba, L; Boscherini, D; Bruni, A; Bruni, G; Cara Romeo, G; Cifarelli, Luisa; Cindolo, F; Contin, A; Corradi, M; De Pasquale, S; Giusti, P; Iacobucci, G; Levi, G; Margotti, A; Massam, Thomas; Nania, R; Palmonari, F; Pesci, A; Sartorelli, G; Zichichi, A; Aghuzumtsyan, G; Amelung, C; Brock, I; Coboken, K; Goers, S; Hartmann, H; Heinloth, K; Hilger, E; Irrgang, P; Jakob, H P; Kappes, A; Katz, U F; Kerger, R; Kind, O; Paul, E; Rautenberg, J; Schnurbusch, H; Stifutkin, A; Tandler, J; Voss, K C; Weber, A; Wieber, H; Bailey, D S; Barret, O; Brook, N H; Cole, J E; Foster, B; Heath, G P; Heath, H F; Robins, S A; Rodrigues, E; Scott, J; Tapper, R J; Capua, M; Mastroberardino, A; Schioppa, M; Susinno, G; Jeoung, H Y; Kim, J Y; Lee, J H; Lim, I T; Ma, K J; Pac, M Y; Caldwell, A; Liu, W; Liu, X; Mellado, B; Paganis, S; Sampson, S; Schmidke, W B; Sciulli, F; Chwastowski, J; Eskreys, Andrzej; Figiel, J; Klimek, K H; Olkiewicz, K; Piotrzkowski, K; Przybycien, M B; Stopa, P; Zawiejski, L; Bednarek, B; Jelen, K; Kisielewska, D; Kowal, A M; Kowalski, T; Rulikowska-Zarebska, E; Suszycki, L; Szuba, D; Bauerdick, L A T; Behrens, U; Bienlein, J K; Borras, K; Chiochia, V; Crittenden, James Arthur; Dannheim, D; Desler, K; Drews, G; Fox-Murphy, A; Fricke, U; Göbel, F; Göttlicher, P; Graciani, R; Haas, T; Hain, W; Hartner, G F; Hebbel, K; Hillert, S; Koch, W; Kötz, U; Kowalski, H; Labes, H; Löhr, B; Mankel, R; Martens, J; Martínez, M; Milite, M; Moritz, M; Notz, D; Petrucci, M C; Polini, A; Rohde, M; Savin, A A; Schneekloth, U; Selonke, F; Sievers, M; Stonjek, S; Wolf, G; Wollmer, U; Youngman, C; Zeuner, W; Coldewey, C; López-Duran-Viani, A; Meyer, A; Schlenstedt, S; Straub, P B; Barbagli, G; Gallo, E; Parenti, A; Pelfer, P G; Bamberger, Andreas; Benen, A; Coppola, N; Eisenhardt, S; Markun, P; Raach, H; Wölfle, S; Bussey, Peter J; Bell, M; Doyle, A T; Glasman, C; Lee, S W; Lupi, A; MacDonald, N; McCance, G J; Saxon, D H; Sinclair, L E; Skillicorn, Ian O; Waugh, R; Bodmann, B; Gendner, N; Holm, U; Salehi, H; Wick, K; Yildirim, A; Carli, T; Garfagnini, A; Geiser, A; Gialas, I; Kcira, D; Klanner, Robert; Lohrmann, E; Goncalo, R; Long, K R; Miller, D B; Tapper, A D; Walker, R; Cloth, P; Filges, D; Ishii, T; Kuze, M; Nagano, K; Tokushuku, K; Yamada, S; Yamazaki, Y; Boos, E G; Pokrovskiy, N S; Zhautykov, B O; Barakbaev, A N; Ahn, S H; Lee, S B; Park, S K; Lim, H; Son, D; Barreiro, F; García, G; González, O; Labarga, L; Del Peso, J; Redondo, I; Terron, J; Vázquez, M E; Barbi, M S; Corriveau, F; Padhi, S; Stairs, D G; Wing, M; Tsurugai, T; Antonov, A; Bashkirov, V; Danilov, M V; Dolgoshein, B A; Gladkov, D; Sosnovtsev, V V; Suchkov, S; Dementiev, R K; Ermolov, P F; Golubkov, Yu A; Katkov, I I; Khein, L A; Korotkova, N A; Korzhavina, I A; Kuzmin, V A; Lukina, O Yu; Proskuryakov, A S; Shcheglova, L M; Solomin, A N; Vlasov, N N; Zotkin, S A; Bokel, C; Botje, M; Brümmer, N; Engelen, J; Grijpink, S; Koffeman, E; Kooijman, P M; Schagen, S; Van Sighem, A; Tassi, E; Tiecke, H G; Tuning, N; Velthuis, J J; Vossebeld, Joost Herman; Wiggers, L; De Wolf, E; Bylsma, B; Durkin, L S; Gilmore, J; Ginsburg, C M; Kim, C L; Ling, T Y; Boogert, S; Cooper-Sarkar, A M; Devenish, R C E; Grosse-Knetter, J; Matsushita, T; Ruske, O; Sutton, M R; Walczak, R; Bertolin, A; Brugnera, R; Carlin, R; Dal Corso, F; Dusini, S; Limentani, S; Longhin, A; Posocco, M; Stanco, L; Turcato, M; Adamczyk, L; Iannotti, L; Oh, B Y; Okrasinski, J R; Saull, P R B; Toothacker, W S; Whitmore, J J; Iga, Y; D'Agostini, Giulio; Marini, G; Nigro, A; Cormack, C; Hart, J C; McCubbin, N A; Shah, T P; Epperson, D E; Heusch, C A; Sadrozinski, H F W; Seiden, A; Wichmann, R; Williams, D C; Park, I H; Pavel, N; Abramowicz, H; Dagan, S; Gabareen, A; Kananov, S; Kreisel, A; Levy, A; Abe, T; Fusayasu, T; Kohno, T; Umemori, K; Yamashita, T; Hamatsu, R; Hirose, T; Inuzuka, M; Kitamura, S; Matsuzawa, K; Nishimura, T; Arneodo, M; Cartiglia, N; Cirio, R; Costa, M; Ferrero, M I; Maselli, S; Monaco, V; Peroni, C; Ruspa, M; Sacchi, R; Solano, A; Staiano, A; Bailey, D C; Fagerstroem, C P; Galea, R; Koop, T; Levman, G M; Martin, J F; Mirea, A; Sabetfakhri, A; Butterworth, J M; Gwenlan, C; Hayes, M E; Heaphy, E A; Jones, T W; Lane, J B; West, B J; Ciborowski, J; Ciesielski, R; Grzelak, G; Nowak, R J; Pawlak, J M; Pawlak, R; Smalska, B; Tymieniecka, T; Wróblewski, A K; Zakrzewski, J A

    2001-01-01

    The production and semi-leptonic decay of heavy quarks have been studied in the photoproduction process $e^+p -> e^+ + {dijet} + e^- + X with the ZEUS detector at HERA using an integrated luminosity of 38.5 ${\\rm pb^{-1}}$. Events with photon-proton centre-of-mass energies, $W_{\\gamma p}$, between 134 and 269 GeV and a photon virtuality, Q^2, less than 1 ${\\rm GeV^2}$ were selected requiring at least two jets of transverse energy $E_T^{\\rm jet1(2)} >7(6)$ GeV and an electron in the final state. The electrons were identified by employing the ionisation energy loss measurement. The contribution of beauty quarks was determined using the transverse momentum of the electron relative to the axis of the closest jet, $p_T^{\\rm rel}$. The data, after background subtraction, were fit with a Monte Carlo simulation including beauty and charm decays. The measured beauty cross section was extrapolated to the parton level with the b quark restricted to the region of transverse momentum $p_T^{b} > p_T^{\\rm min} =$ 5 GeV and ...

  3. Longing for Clouds - Does Beautiful Weather have to be Fine?

    Directory of Open Access Journals (Sweden)

    Mădălina Diaconu

    2016-01-01

    Full Text Available Any attempt to outline a meteorological aesthetics centered on so-called beautiful weather has to overcome several difficulties: In everyday life, the appreciation of the weather is mostly related to practical interests or reduced to the ideal of stereotypical fine weather that is conceived according to blue-sky thinking irrespective of climate diversity. Also, an aesthetics of fine weather seems, strictly speaking, to be impossible given that such weather conditions usually allow humans to focus on aspects other than weather, which contradicts the autotelic character of beauty. The unreflective equation of beautiful weather with moderately sunny weather and a cloudless sky also collides with the psychological need for variation: even living in a “paradisal” climate would be condemned to end in monotony. Finally, whereas fine weather is related in modern realistic literature to cosmic harmony and a universal natural order, contemporary literary examples show that in the age of the climate change, fine weather may be deceitful and its passive contemplation, irresponsible. This implies the necessity of a reflective aesthetic attitude on weather, as influenced by art, literature, and science, which discovers the poetics of bad weather and the wonder that underlies average weather conditions.

  4. New Observations of beauty baryon decays at LHCb

    CERN Document Server

    Vitaly, Andreev

    2014-01-01

    This report describes the work I have done during my summer student association with the LHCb (Large Hadron Collider Beauty Experiment) collaboration at CERN from 30.06 till 26.09.2014. The project was performed in a team with two other summer students. In this report I concentrate on my contribution to the team work. In addition, one section is dedicated to the management framework called “scrum” which we used to collaborate as a team. The goal of my task was to analyze yet unobserved decays of the beauty Lambda-b-0 baryon. This is interesting since the CP violation still remains unobserved in baryons and beauty baryons are generally not well-known yet. LHCb is the first detector where these heavy baryons can be analyzed in detail. In addition these decays may play an important role in other processes and one can gain new insights into the strong interaction. The analysis presented here was performed on the full 2011-2012 LHC run data and includes several decays which are observed for the first time.

  5. Measurement of open beauty production in photoproduction at HERA

    Science.gov (United States)

    ZEUS Collaboration; Breitweg, J.; et al.

    2001-01-01

    The production and semi-leptonic decay of heavy quarks have been studied in the photoproduction process e+p -> e+ + dijet + e- + X with the ZEUS detector at HERA using an integrated luminosity of 38.5 pb -1. Events with photon-proton centre-of-mass energies, Wγ p, between 134 and 269 GeV and a photon virtuality, Q2, less than 1 GeV 2 were selected requiring at least two jets of transverse energy ET jet1(2) >7(6) GeV and an electron in the final state. The electrons were identified by employing the ionisation energy loss measurement. The contribution of beauty quarks was determined using the transverse momentum of the electron relative to the axis of the closest jet, pT rel. The data, after background subtraction, were fit with a Monte Carlo simulation including beauty and charm decays. The measured beauty cross section was extrapolated to the parton level with the b quark restricted to the region of transverse momentum pT^b > pT^min = 5 GeV and pseudorapidity |η b| < 2. The extrapolated cross section is 1.6 +/- 0.4 (stat.)+0.3-0.5 (syst.) +0.2-0.4 (ext.) nb. The result is compared to a perturbative QCD calculation performed to next-to-leading order.

  6. Beauty and healing: examining sociocultural expectations of the embodied goddess.

    Science.gov (United States)

    Yeh, Jin-Tsann; Lin, Chyong-Ling

    2013-03-01

    Studies indicate mental health improvement can occur via religious communities offering social support and other resources. Many people from many cultures regard medicine as a supernatural or magical treatment that can somehow lead to a better state of living. In medical advertising, female role portrayal involves the blending of beauty, ritual and attractiveness in combination with the best product image. A Chinese saying suggests that, "A girl will doll herself up for him who loves her." Female role attraction is a very important ethical subject in gender issues. Moving forward in time, female role visualization and consumption in medical advertising reveal depictions that encouraged women to do some self-searching and find, or develop, inner strength. This study is designed to examine female role portrayals in a restricted patriarchal society. The results indicate that the ideology of motherhood is an accepted social orientation that the public readily identifies with. Results further indicate that beautification through medical products incorporates an emotional element of religious healing and that the objectification of beauty in the media reveals a possible neglect of women's internal beauty. PMID:21360223

  7. Photographic emulsion versus bubble chambers in charm and beauty searches

    International Nuclear Information System (INIS)

    This chapter discusses the use of visual detectors in the search for charm and other flavors. The photographic emulsion and the bubble chamber techniques are compared. The main difficulties encounted in searching for charmed and beautiful hadrons are related to the short lifetimes of these particles and to their small production cross-sections, even at SPS energies. Resolution, visibility, the data analysis rate, and exposure time are considered. Most of the charmed hadrons present a large variety of decay modes of which only a fraction has been identified to date. First results from CESR indicate that the average charged particle multiplicity in the hadronic decay of beautiful hadrons is as high as 6.31 + or - 0.35; no B meson decay has yet been kinematically reconstructed. The case of hadronic charmed particle production at SPS energies is examined. The data show that 1) the bubble chamber technique (high resolution or holographic optics) is well suited to the study of charmed hadrons with lifetimes in the range 10-13 to 10-12 s; 2) searches for beautiful hadrons remain presently a domain for triggered emulsion experiments due to the smallness of the production cross-sections (provided the lifetime is not much shorter than 10-14 s); and 3) for particles of lifetimes shorter than a few times 10-14 s the emulsion technique is still without competitor

  8. Directed altruistic living donation: what is wrong with the beauty contest?

    Science.gov (United States)

    Moorlock, Greg

    2015-11-01

    This paper explores the specific criticism of directed altruistic living organ donation that it creates a 'beauty contest' between potential recipients of organs. The notion of the beauty contest in transplantation was recently used by Neidich et al who stated that '[a]ltruism should be the guiding motivation for all donations, and when it [is], there is no place for a beauty contest'. I examine this beauty contest objection from two perspectives. First, I argue that, when considered against the behaviour of donors, this objection cannot be consistently raised without also objecting to other common aspects of organ donation. I then explore the beauty contest objection from the perspective of recipients, and argue that if the beauty contest is objectionable, it is because of a tension between recipient behaviour and the altruism that supposedly underpins the donation system. I conclude by briefly questioning the importance of this tension in light of the organ shortage. PMID:26126975

  9. What is beautiful is good because what is beautiful is desired: physical attractiveness stereotyping as projection of interpersonal goals.

    Science.gov (United States)

    Lemay, Edward P; Clark, Margaret S; Greenberg, Aaron

    2010-03-01

    The authors posit that the attribution of desirable interpersonal qualities to physically attractive targets is a projection of interpersonal goals; people desire to form and maintain close social bonds with attractive targets and then project these motivations onto those targets. Three studies support this model. Tendencies to see attractive novel targets depicted in photographs (Study 1), attractive romantic partners (Study 2), and attractive friends (Study 3) as especially interpersonally receptive and responsive were explained by perceivers' heightened desires to bond with attractive individuals. Additional findings regarding response latencies (Study 1) also supported this model. Many instances of the "beautiful is good" effect may not reflect stereotyping as it is typically construed. Rather, they may reflect projection of heightened desires to bond with beautiful people. PMID:20179314

  10. Aesthetic resources of social survival and sustainable development: The Beauty in Culture

    OpenAIRE

    Ionesov, Vladimir

    2015-01-01

    The aim of this article is study of the phenomenon of beauty in culture and aesthetic resources of social survival in changing world. In the broadest sense, beauty is a category indicating complete harmony in an object, based on an ideal correspondence of form and concept. Liberated by beauty, man recovers his lost link with nature and extends the boundaries of his existence. Aesthetic manifestations are very important resource of overcoming of crisis and social trials. Focusing on the charac...

  11. Dormitory of Physical and Engineering Sciences: Sleeping Beauties May Be Sleeping Innovations

    OpenAIRE

    van Raan, Anthony F. J.

    2015-01-01

    A 'Sleeping Beauty in Science' is a publication that goes unnoticed ('sleeps') for a long time and then, almost suddenly, attracts a lot of attention ('is awakened by a prince'). The aim of this paper is to present a general methodology to investigate (1) important properties of Sleeping Beauties such as the time-dependent distribution, author characteristics, journals and fields, and (2) the cognitive environment of Sleeping Beauties. We are particularly interested to find out to what extent...

  12. Shaping the female student : an analysis of Swedish beauty school recruitment texts

    OpenAIRE

    Bredlöv, Eleonor

    2016-01-01

    This study focuses on the recruitment of adults to the beauty industry in Sweden. It is concerned with a move in (beauty) education away from state and towards private provision in a wider context where education is becoming more heavily marketised. Drawing on a poststructural approach inspired by the work of Foucault and feminist theory, the shaping of student subjectivity in recruitment material for private beauty schools is analysed. A poststructural approach provides analytical tools that...

  13. Determination of toxic elements in beauty creams by X-ray spectrometric techniques (2001-2002)

    International Nuclear Information System (INIS)

    This paper is carried out to examine the contents of toxic heavy metals in various kinds of beauty creams by using Energy Dispersive X-ray Fluorescence Technique (EDXRF). By applying EDXRF system, it si found that most of the beauty creams contained titanium and zinc, and some of the beauty creams contained lead, bismuth, iron and mercury. Among the heavy toxic metals, mercury is the most harmful to human's health. (author)

  14. Socio-economic Conditions of Tribal Female Workers of the Beauty Parlors in Bangladesh

    OpenAIRE

    Nargis Akhter; Feroz Ahmed; Sohrab Hossain

    2011-01-01

    The study highlights the socio-economic conditions of tribal female workers of the beauty parlors in Bangladesh. The study consists of 240 sample tribal female workers of the different beauty parlors situated in six divisional towns of Bangladesh and judgment sampling technique was used to select this sample. The study reveals that tribal women working at beauty parlor draw competitively higher salary than other tribal people; they live at a comparatively healthy physical environment provided...

  15. Measurement of beauty quark mass at HERA and impact on Higgs production in association with beauty quarks at LHC

    CERN Document Server

    Gizhko, Andrii

    2016-01-01

    Three different, but related topics are the subject of this thesis, performed in the contextof the ZEUS and CMS groups at DESY. The first measurement of the MS beauty-quarkmass mb (mb ) at an electron-proton collider is presented. The measurement is based ona QCD analysis of beauty production cross sections in deep inelastic (DIS) ep scatteringmeasured by ZEUS at HERA, together with inclusive DIS HERA data, using Next-toLeading-Order QCD predictions. The measured value of the running beauty-quark massin the MS scheme was found to bemb (mb ) = 4.07 ± 0.14 (fit)+0.01 (mod.)+0.05 (param.) +0.08 (theo.) GeV, which is in good−0.07−0.00−0.05agreement with the world average Particle Data Group value and previous measurementsat electron-positron colliders. It is also found to be consistent with the expected runningof mb (µ).A first measurement of the charm-quark mass mc (µ) running in the MS scheme ispresented. The measurement is based on a QCD analysis of the published H1 and ZEUScombination of charm cr...

  16. The Khuner Haus by Adolf Loos - a critical study of beauty and desire

    DEFF Research Database (Denmark)

    Fisker, Anna Marie; Hvejsel, Marie Frier; Møller, Hans Ramsgaard

    Pondering about beauty’s relevance, meanings, and perhaps even the spell beauty can cast, we settle in comfortable chairs on the terrace of the Khuner Haus in the mountains close to Vienna. Heavy drifting clouds nearly touch the ground on the plateau around us this autumn afternoon. Our goal is to...... decipherer the architect Adolf Loos’ work, the Khuner Haus, and we put forth the question; do we in Loos’ architecture and thinking find a “Beauty in spite of Nature” as opposed to a “Beauty within Nature”? And if this is the dispute, how has the existence of beauty been challenged? The point of departure...... for our exploration of critical issues about Beauty is the theories of Adolf Loos and Immanuel Kant. To classify Loos’ two views on beauty, both driven by the desire to create more beautiful, we focus on Kant’s work “The critique of judgment” in order to define beauty or the beautifulness. Can the...

  17. The ratio of the beauty structure functions Rb=(FLb)/(F2b) at low x

    International Nuclear Information System (INIS)

    We study the structure functions Fkb(x,Q2) (k=2,L) and the reduced cross section σrb(x,Q2) for small values of Bjorken's x variable with respect to the hard (Lipatov) pomeron for the gluon distribution and provide a compact formula for the ratio Rb that is useful to extract the beauty structure function from the beauty reduced cross section, in particular at DESY HERA. Also we show that the effects of the nonlinear corrections to the gluon distribution tame the behavior of the beauty structure function and the beauty reduced cross section at low x

  18. PA01.75. Hidden beauty concepts in ayurveda w.r.t agada tantra

    OpenAIRE

    Kalyanimath, Gurusiddeshwar J.; Sharanesh, T.; Ashwinikumar,; Anita, M.; ,

    2012-01-01

    Purpose: Beauty is not in the face; Beauty is a light in the heart. In our Ayurveda it is stated that Physical, Mental and Spiritual beauty as a combined unit projects the cosmetic sense of Ayurveda (Ch.Su 1/41). According to Ayurveda healthy skin is the result of overall condition of individuals and prescribes numerous skin care treatments that need to be pursued at every stage of life. Ayurveda determines beauty by Prakruti(body constitution), Sara (structural predominance), Samhanana (comp...

  19. Evaluation of various anthropometric proportions in Indian beautiful faces: A photographic study

    Directory of Open Access Journals (Sweden)

    Saaransh Kalra

    2015-01-01

    Full Text Available Introduction: The subject of beauty has been the topic of much debate throughout history, and methods for the evaluation of beauty have been the focus of many research projects. The evaluation of beauty is influenced by factors which include various linear measurements, angles, ratios, and proportions. We evaluated several ratios in Indian Population after locating various landmarks on beautiful Indian faces. Aims and Objectives: The aim of the present study was to evaluate various facial proportions of Indian beauties using their frontal photographs in natural head position to establish anthropometric norms in beautiful Indian females. To evaluate whether these values satisfy golden and silver proportions. To compare these values with Caucasian anthropometric norms. Materials and Methods: Frontal photographs of 30 female celebrities were downloaded from the internet. Photographs of only those Indian beauties that have been declared winners of either national or international beauty contests by a designated panel of judges were included in this study. Hardcopy of these photographs was taken in 5 inch by 3.5 inch format, all the measurements done and ratios calculated. Results: Measurements were tabulated and values for various ratios were calculated to establish norms. Coefficient of variation was also evaluated. Conclusion: All the ratios were found to be consistent than others which made it possible to assess beauty objectively rather than arbitrarily. Most of the values did not match the golden and silver proportion. In comparison with Caucasian population, we found that there is significant difference in most of the values.

  20. Physical attractiveness biases in ratings of employment suitability: tracking down the "beauty is beastly" effect.

    Science.gov (United States)

    Johnson, Stefanie K; Podratz, Kenneth E; Dipboye, Robert L; Gibbons, Ellie

    2010-01-01

    The "what is beautiful is good" heuristic suggests that physically attractive persons benefit from their attractiveness in a large range of situations, including perceptions of employment suitability. Conversely, the "beauty is beastly" effect suggests that attractiveness can be detrimental to women in certain employment contexts, although these findings have been less consistent than those for the "what is beautiful is good" effect. The current research seeks to uncover situations in which beauty might be detrimental for female applicants. In two studies, we found that attractiveness can be detrimental for women applying for masculine sex-typed jobs for which physical appearance is perceived as unimportant. PMID:20575336

  1. First look at beauty and beauty-jet tagging via secondary vertexing with ALICE in p+p collisions at √S = 7 TeV

    International Nuclear Information System (INIS)

    The heavy flavour single electron data from RHIC indicate strong coupling of heavy quarks to the medium. The LHC extends greatly the kinematic range to high transverse momentum which enables new tests of heavy quark jet dynamics. Jets containing beauty hadrons have distinctive properties from other types of jets, which enhance their clear identification. We first introduce a method to preferentially select electrons from beauty hadron decay by reconstructing secondary vertices and show the results of this approach on simulated data. A preliminary look at the heavy flavour electron analysis and the beauty analysis in p+p collisions at √S = 7 TeV is also presented. (author)

  2. Biogenic volatile organic compounds - small is beautiful

    Science.gov (United States)

    Owen, S. M.; Asensio, D.; Li, Q.; Penuelas, J.

    2012-12-01

    While canopy and regional scale flux measurements of biogenic volatile organic compounds (bVOCs) are essential to obtain an integrated picture of total compound reaching the atmosphere, many fascinating and important emission details are waiting to be discovered at smaller scales, in different ecological and functional compartments. We concentrate on bVOCs below ground to pollination of flowers. Although bVOC emissions from soil surfaces are small, bVOCs are exuded by roots of some plant species, and can be extracted from decaying litter. Naturally occurring monoterpenes in the rhizosphere provide a specialised carbon source for micro-organisms, helping to define the micro-organism community structure, and impacting on nutrient cycles which are partly controlled by microorganisms. Naturally occurring monoterpenes in the soil system could also affect the aboveground structure of ecosystems because of their role in plant defence strategies and as mediating chemicals in allelopathy. A gradient of monoterpene concentration was found in soil around Pinus sylvestris and Pinus halepensis, decreasing with distance from the tree. Some compounds (α-pinene, sabinene, humulene and caryophyllene) in mineral soil were linearly correlated with the total amount of each compound in the overlying litter, indicating that litter might be the dominant source of these compounds. However, α-pinene did not fall within the correlation, indicating a source other than litter, probably root exudates. We also show that rhizosphere bVOCs can be a carbon source for soil microbes. In a horizontal gradient from Populus tremula trees, microbes closest to the tree trunk were better enzymatically equipped to metabolise labeled monoterpene substrate. Monoterpenes can also increase the degradation rate in soil of the persistant organic pollutants, likely acting as analogues for the cometabo-lism of polychlorinated biphenyls (PCBs) Flowers of a ginger species (Alpinia kwangsiensis) and a fig species

  3. Sexual selection, redundancy and survival of the most beautiful

    Indian Academy of Sciences (India)

    R D Morris; J A Morris

    2004-09-01

    A model is described of a highly redundant complex organism that has overlapping banks of genes such that each vital function is specified by several different genetic systems. This generates a synergistic profile linking probability of survival to the number of deleterious mutations in the genome. Computer models show that there is a dynamic interaction between the mean number of new deleterious mutations per generation (), the mean number of deleterious mutations in the genome of the population () and percentage zygote survival (Zs). Increased leads to increased and a fall in Zs but it takes several generations before a new equilibrium is reached. If sexual attraction is influenced by the number of deleterious mutations in the genome of individuals then is reduced and Zs increased for any given value of . This fall in and rise in Zs is more marked in polygamous than monogamous mating systems. The model is specified such that deleterious mutations can occur without any observable or measurable effect on function. Thus sexual selection, in this organism, for low levels of deleterious mutations cannot be based on assessment of performance. Instead it is based on a simple symmetrical surface pattern that is flawlessly reproduced by organisms with no deleterious mutations, but is less than perfect, and therefore less attractive, if genetic systems have been deleted. A complex vital task requires a system with a high level of redundancy that acts so that the loss of one component has no observable effect and therefore cannot be used for sexual selection. The reproduction of a beautiful surface pattern also requires a low error, high redundancy genetic system; however, in this case there is advantage if a single deleterious mutation produces a recognisable change. This leads to the conclusion that sexual selection and sexual attraction should be based on beauty rather than utility, and explains the common observation in nature that it is the most beautiful that

  4. Human facial beauty : Averageness, symmetry, and parasite resistance.

    Science.gov (United States)

    Thornhill, R; Gangestad, S W

    1993-09-01

    It is hypothesized that human faces judged to be attractive by people possess two features-averageness and symmetry-that promoted adaptive mate selection in human evolutionary history by way of production of offspring with parasite resistance. Facial composites made by combining individual faces are judged to be attractive, and more attractive than the majority of individual faces. The composites possess both symmetry and averageness of features. Facial averageness may reflect high individual protein heterozygosity and thus an array of proteins to which parasites must adapt. Heterozygosity may be an important defense of long-lived hosts against parasites when it occurs in portions of the genome that do not code for the essential features of complex adaptations. In this case heterozygosity can create a hostile microenvironment for parasites without disrupting adaptation. Facial bilateral symmetry is hypothesized to affect positive beauty judgments because symmetry is a certification of overall phenotypic quality and developmental health, which may be importantly influenced by parasites. Certain secondary sexual traits are influenced by testosterone, a hormone that reduces immunocompetence. Symmetry and size of the secondary sexual traits of the face (e.g., cheek bones) are expected to correlate positively and advertise immunocompetence honestly and therefore to affect positive beauty judgments. Facial attractiveness is predicted to correlate with attractive, nonfacial secondary sexual traits; other predictions from the view that parasite-driven selection led to the evolution of psychological adaptations of human beauty perception are discussed. The view that human physical attractiveness and judgments about human physical attractiveness evolved in the context of parasite-driven selection leads to the hypothesis that both adults and children have a species-typical adaptation to the problem of identifying and favoring healthy individuals and avoiding parasite

  5. Distinctive Design A Practical Guide to a Useful, Beautiful Web

    CERN Document Server

    Dawson, Alexander

    2011-01-01

    Learn to produce a web site that stands out from the crowd One of the web designer's greatest challenges is to create a site distinctive enough to get noticed among the millions of sites already on the web. This book examines the bond between code, content and visuals to guide you through the factors that increase your design's visibility, usability and beauty. Using this practical advice, even web designers who lack strong artistic skills can develop super sites that strengthen the message and stand out from the crowd.Most books focus primarily on graphic design principles; this one shows you

  6. The curtain of reality. The secret beauty of deception

    International Nuclear Information System (INIS)

    The physics research is a path on a 'road to reality', to paraphrase the title of a famous essay by R. Penrose. One school of thought interprets mathematics not only as a descriptive tool of reality but as the ultimate structure of reality. In this short note, the author supports this hypothesis speculative showing the performance to be reached by starting an investigation to 'flush out' mathematics and beauty in a symbolic constant of physics that alone could explain and justify the existence of the universe

  7. Fearful Symmetry: The Search for Beauty in Modern Physics

    Energy Technology Data Exchange (ETDEWEB)

    Zakrzewski, W J [Department of Mathematical Sciences Science Laboratory, Durham University, South Road, Durham, DH1 3LE (United Kingdom)

    2008-01-11

    It is easy to see beauty in symmetry when we look at buildings like the Taj Mahal or natural objects such as snowflakes; it is much harder to explain to a non-expert the beauty of equations or of symmetry concepts in relativity or in particle theory. Tony Zee achieves this in a remarkable way, while he also manages to make many complicated concepts accessible to a reader who is genuinely interested and who has some basic/school knowledge of physics. To do this he invents various ordinary world analogies and exploits them in a masterful way. I liked, in particular, his analogy for the colour of quarks and the associated SU(3) symmetry provided by adding colour to ice-cream, which does not change its cost. Of course, sometimes real beauty is associated with a small breakdown of symmetry. We are all familiar with this in music or in art. Tony shows that such a breakdown also has a role in physics and that it is often associated with unexpected and very deep and important concepts (parity, CP violation or baryon assymetry). The book is an amazing achievement; although the main focus is on symmetry and beauty the author manages to explain most of the new and relevant concepts of modern physics, from quantum mechanics and relativity to superstrings and superbranes. And he does this with no equations and almost no mathematical symbols. So who is this book intended for? Who will enjoy reading it? Clearly, it will be appreciated by all theoretical physicists, who probably will be primarily impressed by the way the book makes accessible so many very difficult concepts. I was particularly struck by Tony's ability to explain things in simple terms and to find relevant analogies. It will be also greatly enjoyed by the non-specialist but 'interested' reader; (s)he may find some concepts hard to follow but (s)he will get the general gist of the arguments. It will be also be enjoyed by sixth-formers studying physics and quite possibly will attract some of them to

  8. LHCb: searching for New Physics hidden in beauty and charm

    Energy Technology Data Exchange (ETDEWEB)

    T' Jampens, S. [Laboratoire d' Annecy-le-Vieux de Physique des Particules (CNRS/IN2P3 and Universite de Savoie) 9, chemin de Bellevue, BP 110 F-74941 Annecy-le-Vieux Cedex (France)

    2009-02-15

    Our knowledge of the quark-mixing matrix and of CP violation has been tremendously improved thanks to the B factories and Tevatron: the KM mechanism is the dominant source of CP violation at the electroweak scale. LHCb is one of the six experiments being constructed on the Large Hadron Collider accelerator at CERN. It is a next generation of flavor-physics experiments which will perform precision tests of CP violation and study rare phenomena to unveil physics beyond the Standard Model, if any, in the interactions of charm- and beauty-hadron decays. The current build status of the detector is given followed by selected topics of the expected physics reach.

  9. Measurement of Beauty Particle Lifetimes and Hadroproduction Cross-Section

    CERN Multimedia

    2002-01-01

    We propose an experimental search for beauty particles produced in fixed target hadronic interactions. The essential feature of the proposed experimental technique is the use of two specially designed pieces of hardware~-~a high precision ``decay detector'' and a fast secondary vertex trigger processor. If these devices perform to our expectations, we should be able to obtain sufficient data sample to address several important physics issues, including measurements of the lifetimes of charged and neutral B~mesons, the B~hadroproduction cross-section, and possibly B$^0$- $ \\bar{B} ^0 $ mixing.

  10. Rhinoplasty and its effects on the perception of beauty

    Directory of Open Access Journals (Sweden)

    Chinski, Hernan

    2013-01-01

    Full Text Available Introduction: Experts on nasal cosmetics and nasal surgery agree that aesthetic rhinoplasty leads to overall facial beautification and the perception of youth in patients. This "assumed truth" has never been proven in the international literature. Aim: To examine increases in facial attractiveness ratings after rhinoplasty surgery. Methods: We conducted a study series by choosing 30 female patients on whom we had operated and 25 evaluators in a single blind trial. The evaluators graded the patients' attractiveness before and after surgery. Results: Beauty indices were significantly improved after the operation. Conclusion: According to the third-party evaluation, the patients appeared prettier after undergoing aesthetic rhinoplasty.

  11. Fearful Symmetry: The Search for Beauty in Modern Physics

    International Nuclear Information System (INIS)

    It is easy to see beauty in symmetry when we look at buildings like the Taj Mahal or natural objects such as snowflakes; it is much harder to explain to a non-expert the beauty of equations or of symmetry concepts in relativity or in particle theory. Tony Zee achieves this in a remarkable way, while he also manages to make many complicated concepts accessible to a reader who is genuinely interested and who has some basic/school knowledge of physics. To do this he invents various ordinary world analogies and exploits them in a masterful way. I liked, in particular, his analogy for the colour of quarks and the associated SU(3) symmetry provided by adding colour to ice-cream, which does not change its cost. Of course, sometimes real beauty is associated with a small breakdown of symmetry. We are all familiar with this in music or in art. Tony shows that such a breakdown also has a role in physics and that it is often associated with unexpected and very deep and important concepts (parity, CP violation or baryon assymetry). The book is an amazing achievement; although the main focus is on symmetry and beauty the author manages to explain most of the new and relevant concepts of modern physics, from quantum mechanics and relativity to superstrings and superbranes. And he does this with no equations and almost no mathematical symbols. So who is this book intended for? Who will enjoy reading it? Clearly, it will be appreciated by all theoretical physicists, who probably will be primarily impressed by the way the book makes accessible so many very difficult concepts. I was particularly struck by Tony's ability to explain things in simple terms and to find relevant analogies. It will be also greatly enjoyed by the non-specialist but 'interested' reader; (s)he may find some concepts hard to follow but (s)he will get the general gist of the arguments. It will be also be enjoyed by sixth-formers studying physics and quite possibly will attract some of them to study science at

  12. Beautiful Math, Part 5: Colorful Archimedean Tilings from Dynamical Systems.

    Science.gov (United States)

    Ouyang, Peichang; Zhao, Weiguo; Huang, Xuan

    2015-01-01

    The art of tiling originated very early in the history of civilization. Almost every known human society has made use of tilings in some form or another. In particular, tilings using only regular polygons have great visual appeal. Decorated regular tilings with continuous and symmetrical patterns were widely used in decoration field, such as mosaics, pavements, and brick walls. In science, these tilings provide inspiration for synthetic organic chemistry. Building on previous CG&A “Beautiful Math” articles, the authors propose an invariant mapping method to create colorful patterns on Archimedean tilings (1-uniform tilings). The resulting patterns simultaneously have global crystallographic symmetry and local cyclic or dihedral symmetry. PMID:26594960

  13. Gender, Work, and Identity: Beauty Salons in Bogotá

    Directory of Open Access Journals (Sweden)

    Luz Gabriela Arango Gaviria

    2012-12-01

    Full Text Available This article examines hair salons, beauty parlors and barbershops in Bogotá from threeperspectives; first, as a space that offers a variety of services and aesthetic possibilities ina context of high informality and of class, race, and gender inequality; secondly, as workmarked by sexual and social divisions, in terms of both jobs and attention to the clientele,centered around “emotional work”; and thirdly, as a field of both cultural expressionand conflict with ethnic, racial and sexual aspects. Based on fieldwork and on a focus onintersectionality, the article explores these social differences as manifested in these jobswithin the processes of subsistence and professionalization.

  14. Teaching Reflection on the Beauty of Bridge%《桥之美》的教学感想

    Institute of Scientific and Technical Information of China (English)

    康乐阗

    2011-01-01

    This paper hopes to lead teachers and students to discover the beauty, appreciate the beauty and taste the beauty in learning and life based on the introduction on the Beauty of Bridge.%本文通过对《桥之美》的介绍,引导教师及学生在学习与生活中学会发现关、欣赏美、品味美。

  15. A twentieth-century triangle trade: selling black beauty at home and abroad, 1945–1965.

    Science.gov (United States)

    McAndrew, Malia

    2010-01-01

    This study examines the careers of African American beauty culturists as they worked in the United States, Europe, and Africa between 1945 and 1965. Facing push back at home, African American beauty entrepreneurs frequently sought out international venues that were hospitable and receptive to black Americans in the years following World War II. By strategically using European sites that white Americans regarded as the birthplace of Western fashion and beauty, African American entrepreneurs in the fields of modeling, fashion design, and hair care were able to win accolades and advance their careers. In gaining support abroad, particularly in Europe, these beauty culturists capitalized on their international success to establish, legitimize, and promote their business ventures in the United States. After importing a positive reputation for themselves from Europe to the United States, African American beauty entrepreneurs then exported an image of themselves as the world's premier authorities on black beauty to people of color around the globe as they sold their products and marketed their expertise on the African continent itself. This essay demonstrates the important role that these black female beauty culturists played, both as businesspeople and as race leaders, in their generation's struggle to gain greater respect and opportunity for African Americans both at home and abroad. In doing so it places African American beauty culturists within the framework of transatlantic trade networks, the Black Freedom Movement, Pan-Africanism, and America's Cold War struggle. PMID:21114069

  16. The Contribution of Scenic Beauty Indicators in Estimating Environmental Welfare Measures: A Case Study

    Science.gov (United States)

    Fanariotu, Ioanna; Skuras, Dimitris

    2004-01-01

    Aesthetic indicators of landscapes, expressed as individual scenic beauty estimates, may be used as proxies of individuals' specific aesthetic values, and improve the properties of welfare estimates produced by contingent valuation models. This work presents results from an interdisciplinary study where forest scenic beauty indicators are utilized…

  17. Creating a Beautiful Mess: Ten Essential Play Experiences for a Joyous Childhood

    Science.gov (United States)

    Gadzikowski, Ann

    2015-01-01

    When children play, they often create a mess, but what a beautiful mess it is! "Creating a Beautiful Mess" describes the ten most important play experiences all children enjoy and how these experiences support learning, creativity, and social connections. These broad categories of play include building with blocks, pretending and make…

  18. The Beauty of the Psyche and Eros Myth: Integrating Aesthetics into Introduction to Psychology

    Science.gov (United States)

    Diessner, Rhett; Burke, Kayla

    2011-01-01

    Beginning in the late 1990s the authors became convinced that their undergraduate psychology students needed classroom experiences that set the conditions for them to become more engaged with beauty. They recognized the intrinsic importance of beauty to human psychological development, beyond any utilitarian concerns. But they also believed that…

  19. 75 FR 10561 - Pricing for 2010 United States Mint America the Beautiful QuartersTM

    Science.gov (United States)

    2010-03-08

    ... United States Mint Pricing for 2010 United States Mint America the Beautiful Quarters\\TM\\ Two-Roll Set, etc. AGENCY: United States Mint, Department of the Treasury. ACTION: Notice. SUMMARY: The United States Mint is announcing the price of the 2010 United States Mint America the Beautiful Quarters...

  20. Shaping the Female Student: An Analysis of Swedish Beauty School Recruitment Texts

    Science.gov (United States)

    Bredlöv, Eleonor

    2016-01-01

    This study focuses on the recruitment of adults to the beauty industry in Sweden. It is concerned with a move in (beauty) education away from state and towards private provision in a wider context where education is becoming more heavily marketised. Drawing on a poststructural approach inspired by the work of Foucault and feminist theory, the…

  1. Small Is Not Always Beautiful – A Comparative Study Of Working Conditions

    DEFF Research Database (Denmark)

    Sørensen, Ole Henning; Hasle, Peter; Bach, Elsa;

    2004-01-01

    When considering working conditions, the myth sometimes holds that small is beautiful. Some studies of occupational accidents show that small companies have fever accidents than large. This indicates that small companies have better working conditions than large. A Danish study based on a random...... reason why small seems beautiful....

  2. Beauty Culture: A Teacher's Guide to an Employment Orientation Course for Special Needs Students.

    Science.gov (United States)

    Grubb, Francine

    This teacher's guide on beauty culture is one of a series of six designed for the employment orientation program for special needs students at the Gloucester County Vocational-Technical School in Sewell, New Jersey. The series includes laundry, hospitality, sewing, basic business, food, and beauty culture. Each guide contains lesson plans…

  3. 76 FR 65563 - Pricing for America the Beautiful Five Ounce Silver Uncirculated CoinsTM

    Science.gov (United States)

    2011-10-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY United States Mint Pricing for America the Beautiful Five Ounce Silver Uncirculated Coins TM AGENCY... announcing the re-pricing of the America the Beautiful Five Ounce Silver Uncirculated Coins. The price of...

  4. 77 FR 840 - Pricing for America the Beautiful Five Ounce Silver Uncirculated CoinsTM

    Science.gov (United States)

    2012-01-06

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY United States Mint Pricing for America the Beautiful Five Ounce Silver Uncirculated Coins TM AGENCY... announcing the re-pricing of the America the Beautiful Five Ounce Silver Uncirculated Coins. The price of...

  5. Beauty and beauty-jet measurement via displaced vertices with ALICE in p+p collisions at {radical}(s) = 7 TeV

    Energy Technology Data Exchange (ETDEWEB)

    Kweon, Min Jung [Universitaet Heidelberg Physikalisches Institut, Heidelberg (Germany); Collaboration: ALICE-Collaboration

    2011-07-01

    The measurement of single electrons from heavy flavor hadron decays at RHIC indicates strong coupling of heavy quarks to the medium produced in ultra relativistic heavy-ion collisions. The LHC extends greatly the kinematic range to high transverse momentum which enables new tests of heavy quark jet dynamics. The beauty hadrons and jets containing beauty hadrons have distinctive properties, which allow for their clear identification. We introduce methods to preferentially select electrons from beauty hadron decays by minimum distance of closest approach cuts and by reconstructing secondary vertices. The first analysis applying these techniques in the ALICE experiment for p+p collisions at {radical}(s)=7 TeV is presented. The analysis status of the data from Pb+Pb collisions, which will allow us to understand beauty quark energy loss in the medium, is also reported.

  6. 76 FR 15047 - Pricing for 2010 United States Mint America the Beautiful Quarters Silver Proof SetTM

    Science.gov (United States)

    2011-03-18

    ... United States Mint Pricing for 2010 United States Mint America the Beautiful Quarters Silver Proof Set\\TM\\, etc. ACTION: Pricing for 2010 United States Mint America the Beautiful Quarters Silver Proof Set TM ; 2010 United States Mint Silver Proof Set TM ; 2011 United States Mint America the Beautiful...

  7. The production of knowledge related to body and beauty: implications for physical education

    Directory of Open Access Journals (Sweden)

    Liege Monique Filgueiras da Silva

    2013-06-01

    Full Text Available The text it is a part of a research Masters, held at the Graduate Program in Education of UFRN. To this end, we considered the relationship between the meanings of body and beauty products analyzed and identified in the models of beauty in Physical Education. This research is qualitative in nature, and content analysis for data processing. The corpus of analysis consisted of eight papers in the area of Physical Education, published in the Bank of Capes Thesis from 2004 to 2008, selected from the subject body and beauty. It was observed that the understanding of body and beauty in the area has been re-signified, which represents the development that has occurred in the tract of the body of knowledge and beauty.

  8. On Hanging Laundry: The Place of Beauty in Managing Everyday Life

    Directory of Open Access Journals (Sweden)

    Pauliina Rautio

    2009-01-01

    Full Text Available The data of my empirical research in the field of education discussed in this paper consist of letters produced through correspondence. I asked the participants to write about beauty in their everyday lives, giving substance to the concept as freely as they could. In this paper it is only the letters of one participant, Laura, which I limit my attention to. The aim is to find out what kind of place beauty, as defined and used by herself, holds in the managing of her everyday life. The concept of beauty is virtually missing from educational research or is misguidedly restricted only to formal art education. Beauty being for Laura an occasional checking of direction in relation to changes both in the context of her everyday life and in herself as a person sheds light to the relevance of beauty at the constitutive and perceptual level of growing as a human being.

  9. Thinking on Beautiful Countryside Construction Based on Land Consolidation in Hefei City

    Institute of Scientific and Technical Information of China (English)

    Wei; WANG; Zhongxiang; YU

    2013-01-01

    This paper stated the background under which beautiful countryside construction was proposed;reviewed the new countryside construction profile of Hefei City before beautiful countryside construction was proposed;analyzed the practices of beautiful countryside construction of Hefei City from the perspective of the land consolidation when considering the development of new-type urbanization conjunctively;then,on the basis of the analysis,it proposed a consideration that the land consolidation and beautiful countryside construction practices of Hefei City should be used for reference,that is to say,the city should focus on beautiful countryside construction planning and comprehensively promote the land consolidation.And it also indicated that there were three kinds of relations needed to be treated well and"five combinations"needed to be done well in land consolidation.

  10. Host modulation by therapeutic agents

    Directory of Open Access Journals (Sweden)

    Sugumari Elavarasu

    2012-01-01

    Full Text Available Periodontal disease susceptible group present advanced periodontal breakdown even though they achieve a high standard of oral hygiene. Various destructive enzymes and inflammatory mediators are involved in destruction. These are elevated in case of periodontal destruction. Host modulation aims at bringing these enzymes and mediators to normal level. Doxycycline, nonsteroidal anti-inflammatory drugs (NSAIDs, bisphosphonates, nitrous oxide (NO synthase inhibitors, recombinant human interleukin-11 (rhIL-11, omega-3 fatty acid, mouse anti-human interleukin-6 receptor antibody (MRA, mitogen-activated protein kinase (MAPK inhibitors, nuclear factor-kappa B (NF-kb inhibitors, osteoprotegerin, and tumor necrosis factor antagonist (TNF-α are some of the therapeutic agents that have host modulation properties.

  11. The influence of electronic-word-of-mouth on consumer decision-making for beauty products in a Kuwaiti Women's online community

    OpenAIRE

    Alhaidari, N; Coughlan, J.

    2014-01-01

    Online communities are an important source of electronic-word-of-mouth (eWOM), however few studies have examined these types of messages within the Middle Eastern context. This study focuses on Kuwaiti women as members of an online beauty forum; previous work has suggested a mediating effect of gender with women being more likely to trust and follow-up word-of-mouth with a purchase. A conceptual model, based on existing theoretical contributions, provides the basis of a coding framework for t...

  12. Feminism Interpretation of the Beauties in American Beauty%解析《美国丽人》中的女性

    Institute of Scientific and Technical Information of China (English)

    田利红

    2012-01-01

    从心理学家荣格的人格原型学说和巴赫金的丑角化理论,展开美国电影《美国丽人》中丽人们的角色剖析,从而对父权制的无形压迫进行了深层次的控诉。%From the perspectives of psychologist C.G.Jung's human psyche and Bakhtin's clown theory probing the female characters in American film American Beauty, it aims to expose and accuse of the invisible oppression of patriarchy system upon women.

  13. Decay Constants of Beauty Mesons from QCD Sum Rules

    CERN Document Server

    Lucha, Wolfgang; Simula, Silvano

    2014-01-01

    Our recently completed analysis of the decay constants of both pseudoscalar and vector beauty mesons reveals that in the bottom-quark sector two specific features of the sum-rule predictions show up: (i) For the input value of the bottom-quark mass in the $\\overline{\\rm MS}$ scheme $\\overline{m}_b(\\overline{m}_b)\\approx4.18\\;\\mbox{GeV},$ the sum-rule result $f_B\\approx210$-$220\\;\\mbox{MeV}$ for the $B$ meson decay constant is substantially larger than the recent lattice-QCD finding $f_B\\approx190\\;\\mbox{MeV}.$ Requiring QCD sum rules to reproduce the lattice-QCD value of $f_B$ yields a significantly larger $b$-quark mass: $\\overline{m}_b(\\overline{m}_b)=4.247\\;\\mbox{GeV}.$ (ii) Whereas QCD sum-rule predictions for the charmed-meson decay constants $f_D,$ $f_{D_s},$ $f_{D^*}$ and $f_{D_s^*}$ are practically independent of the choice of renormalization scale, in the beauty sector the results for the decay constants - and especially for the ratio $f_{B^*}/f_B$ - prove to be very sensitive to the specific scale s...

  14. Decay Constants of Beauty Mesons from QCD Sum Rules

    Directory of Open Access Journals (Sweden)

    Lucha Wolfgang

    2014-01-01

    Full Text Available Our recently completed analysis of the decay constants of both pseudoscalar and vector beauty mesons reveals that in the bottom-quark sector two specific features of the sum-rule predictions show up: (i For the input value of the bottom-quark mass in the M̅S̅ scheme m̅b(m̅b ≈ 4:18 GeV; the sum-rule result fB ≈ 210–220 MeV for the B meson decay constant is substantially larger than the recent lattice-QCD finding fB ≈ 190 MeV: Requiring QCD sum rules to reproduce the lattice-QCD value of fB yields a significantly larger b-quark mass: m̅b(m̅b = 4:247 GeV: (ii Whereas QCD sum-rule predictions for the charmed-meson decay constants fD; fDs, fD* and fDs* are practically independent of the choice of renormalization scale, in the beauty sector the results for the decay constants—and especially for the ratio fB* / fB—prove to be very sensitive to the specific scale setting.

  15. Hidden-beauty charged tetraquarks and heavy quark spin conservation

    Energy Technology Data Exchange (ETDEWEB)

    Ali, A. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Maiani, L.; Polosa, A.D.; Riquer, V. [Rome-3 Univ. (Italy). Dipt. di Fisica; INFN, Sezione di Roma (Italy)

    2014-12-15

    Assuming the dominance of the spin-spin interaction in a diquark, we point out that the mass differences in the beauty sector M(Z'{sub b}){sup ±}-M(Z{sub b}){sup ±} scale with quark masses as expected in QCD, with respect to the corresponding mass difference M(Z'{sub c}){sup ±}-M(Z{sub c}){sup ±}. Notably, we show that the decays Υ(10890)→(h{sub b}(1P),h{sub b}(2P))π{sup +}π{sup -} are compatible with heavy-quark spin conservation once the contributions of Z{sub b},Z'{sub b} intermediate states are taken into account, Υ(10890) being either a Υ(5S) or the beauty analog of Y{sub c}(4260). We also consider the role of Z{sub b},Z'{sub b} in Υ(10890)→Υ(nS)ππ decays and of light quark spin non-conservation in Z{sub b}, Z'{sub b} decays into BB{sup *} and B{sup *}B{sup *}. Indications on possible signatures of the still missing X{sub b} resonance are proposed.

  16. A tevatron collider beauty factory. [Final report, 1980--1992

    Energy Technology Data Exchange (ETDEWEB)

    1992-12-31

    This document which is labeled a final report consists of several different items. The first is a proposal for a detector to be developed for beauty physics. The detector is proposed for the Fermilab Tevatron, and would be designed to measure mixing reactions, rare decay modes, and even CP violation in hadron collider beauty production. The general outline of the work proposed is given, and an estimate of the time to actually design the detector is presented, along with proposed changes to the Tevatron to accommodate the system. A preliminary report on an experiment to verify a reported observation of a 17 keV neutrino in tritium decay is presented. The present results in the decay spectra actually show a depression below expected levels, which is not consistent with a massive neutrino. Additional interest has been shown in finishing an electrostatic beta spectrometer which was started several years previously. The instrument uses hemispherical electrostatic electric fields to retard electrons emitted in tritium decay, allowing measurement of integral spectra. The design goal has a 5 eV energy resolution, which may be achievable. A new PhD student is pursuing this experiment. Also the report contains a proposal for additional work in the field of non-perturbative quantum field theory by the theoretical group at OU. The work which is proposed will be applied to electroweak and strong interactions, as well as to quantum gravitational phenomena.

  17. Experimental aspects of open charm and beauty hadroproduction

    International Nuclear Information System (INIS)

    The last few years have witnessed a big effort to determine the experimental properties of open heavy flavour production. This study presents a number of experiments which have been performed with diverse techniques: high resolution bubble chamber coupled to a downstream spectrometer, emulsions, counters, looking for both direct and indirect signature of charm and beauty. As the situation on open beauty hadroproduction has not altered since the last review in this series of symposia this article concentrates on the recent experiments on charm. The problems of cleanly identifying short lived charm particles (tau ≤ 10/sup -12/ s) in a relatively rare process (-- 10/sup -2/ - 10/sup -3/ times σ/sub inel/) are compounded by the presence of a high primary multiplicity environment. In addition to these inherent physics problems one encounters additional difficulties if one attempts to compare results because different experiments use different target materials, are sensitive to different decay modes and have different kinematic acceptances. In the absence of reliable knowledge of branching ratios and A and x/sub F/ dependences a gross property like the total charm production cross section is not reliably determined

  18. J/ψ production and beauty physics at CDF

    International Nuclear Information System (INIS)

    The Fermilab proton-antiproton collider makes about 50 beauty mesons per second, giving a unique opportunity to test the higher order QCD calculations that have recently been completed. CDF, the Collider Detector at Fermilab, finished its first large-scale data run in June 1989, recording 4.7 pb-1 using a variety of triggers. As of this workshop, only half of the data have been fully reconstructed, and the beauty analysis is at an early stage. Therefore this paper shows only work-in-progress on the analysis methods. The authors estimate the B cross section to be consistent with theoretical predictions. CDF is an azimuthally symmetric detector with good solid angle coverage, consisting of high-granularity hadron calorimeters and shower counters, high-resolution tracking in an 1.4-T axial magnetic field, a vertex time projection chamber, and muon tracking. This paper shows the geometry of the muon chambers. Sets of muon chambers lie behind five interaction lengths of calorimetry, over the angle 56 degrees < θ < 124 degrees from the beam. They have four layers of δφ ∼ 1 degree cells, using charge division to measure the longitudinal track coordinate and drift time for the transverse coordinate. A level-1 trigger rejects low transverse momentum tracks by testing the drift-time difference between alternate layers of the chambers, which amounts to a cut on the bending of the track in the magnetic field

  19. Generation of trangenic Xenopus laevis using the Sleeping Beauty transposon system.

    Science.gov (United States)

    Sinzelle, L; Vallin, J; Coen, L; Chesneau, A; Du Pasquier, D; Pollet, N; Demeneix, B; Mazabraud, A

    2006-12-01

    Using the Sleeping Beauty (SB) transposon system, we have developed a simple method for the generation of Xenopus laevis transgenic lines. The transgenesis protocol is based on the co-injection of the SB transposase mRNA and a GFP-reporter transposon into one-cell stage embryos. Transposase-dependent reporter gene expression was observed in cell clones and in hemi-transgenic animals. We determined an optimal ratio of transposase mRNA versus transposon-carrying plasmid DNA that enhanced the proportion of hemi-transgenic tadpoles. The transgene is integrated into the genome and may be transmitted to the F1 offspring depending on the germline mosaicism. Although the transposase is necessary for efficient generation of transgenic Xenopus, the integration of the transgene occurred by an non-canonical transposition process. This was observed for two transgenic lines analysed. The transposon-based technique leads to a high transgenesis rate and is simple to handle. For these reasons, it could present an attractive alternative to the classical Restriction Enzyme Mediated Integration (REMI) procedure. PMID:16957880

  20. Remobilization of Sleeping Beauty transposons in the germline of Xenopus tropicalis

    Directory of Open Access Journals (Sweden)

    Yergeau Donald A

    2011-11-01

    Full Text Available Abstract Background The Sleeping Beauty (SB transposon system has been used for germline transgenesis of the diploid frog, Xenopus tropicalis. Injecting one-cell embryos with plasmid DNA harboring an SB transposon substrate together with mRNA encoding the SB transposase enzyme resulted in non-canonical integration of small-order concatemers of the transposon. Here, we demonstrate that SB transposons stably integrated into the frog genome are effective substrates for remobilization. Results Transgenic frogs that express the SB10 transposase were bred with SB transposon-harboring animals to yield double-transgenic 'hopper' frogs. Remobilization events were observed in the progeny of the hopper frogs and were verified by Southern blot analysis and cloning of the novel integrations sites. Unlike the co-injection method used to generate founder lines, transgenic remobilization resulted in canonical transposition of the SB transposons. The remobilized SB transposons frequently integrated near the site of the donor locus; approximately 80% re-integrated with 3 Mb of the donor locus, a phenomenon known as 'local hopping'. Conclusions In this study, we demonstrate that SB transposons integrated into the X. tropicalis genome are effective substrates for excision and re-integration, and that the remobilized transposons are transmitted through the germline. This is an important step in the development of large-scale transposon-mediated gene- and enhancer-trap strategies in this highly tractable developmental model system.