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Sample records for beauty mediates therapeutic

  1. Nanocapsule-delivered Sleeping Beauty mediates therapeutic Factor VIII expression in liver sinusoidal endothelial cells of hemophilia A mice.

    Science.gov (United States)

    Kren, Betsy T; Unger, Gretchen M; Sjeklocha, Lucas; Trossen, Alycia A; Korman, Vicci; Diethelm-Okita, Brenda M; Reding, Mark T; Steer, Clifford J

    2009-07-01

    Liver sinusoidal endothelial cells are a major endogenous source of Factor VIII (FVIII), lack of which causes the human congenital bleeding disorder hemophilia A. Despite extensive efforts, gene therapy using viral vectors has shown little success in clinical hemophilia trials. Here we achieved cell type-specific gene targeting using hyaluronan- and asialoorosomucoid-coated nanocapsules, generated using dispersion atomization, to direct genes to liver sinusoidal endothelial cells and hepatocytes, respectively. To highlight the therapeutic potential of this approach, we encapsulated Sleeping Beauty transposon expressing the B domain-deleted canine FVIII in cis with Sleeping Beauty transposase in hyaluronan nanocapsules and injected them intravenously into hemophilia A mice. The treated mice exhibited activated partial thromboplastin times that were comparable to those of wild-type mice at 5 and 50 weeks and substantially shorter than those of untreated controls at the same time points. Further, plasma FVIII activity in the treated hemophilia A mice was nearly identical to that in wild-type mice through 50 weeks, while untreated hemophilia A mice exhibited no detectable FVIII activity. Thus, Sleeping Beauty transposon targeted to liver sinusoidal endothelial cells provided long-term expression of FVIII, without apparent antibody formation, and improved the phenotype of hemophilia A mice.

  2. Sleeping Beauty-Mediated Drug Resistance Gene Transfer in Human Hematopoietic Progenitor Cells

    Science.gov (United States)

    Hyland, Kendra A.; Olson, Erik R.; McIvor, R. Scott

    2015-01-01

    The Sleeping Beauty (SB) transposon system can insert sequences into mammalian chromosomes, supporting long-term expression of both reporter and therapeutic genes. Hematopoietic progenitor cells (HPCs) are an ideal therapeutic gene transfer target as they are used in therapy for a variety of hematologic and metabolic conditions. As successful SB-mediated gene transfer into human CD34+ HPCs has been reported by several laboratories, we sought to extend these studies to the introduction of a therapeutic gene conferring resistance to methotrexate (MTX), potentially providing a chemoprotective effect after engraftment. SB-mediated transposition of hematopoietic progenitors, using a transposon encoding an L22Y variant dihydrofolate reductase fused to green fluorescent protein, conferred resistance to methotrexate and dipyridamole, a nucleoside transport inhibitor that tightens MTX selection conditions, as assessed by in vitro hematopoietic colony formation. Transposition of individual transgenes was confirmed by sequence analysis of transposon–chromosome junctions recovered by linear amplification-mediated PCR. These studies demonstrate the potential of SB-mediated transposition of HPCs for expression of drug resistance genes for selective and chemoprotective applications. PMID:26176276

  3. Comparison of lentiviral and sleeping beauty mediated αβ T cell receptor gene transfer.

    Directory of Open Access Journals (Sweden)

    Anne-Christine Field

    Full Text Available Transfer of tumour antigen-specific receptors to T cells requires efficient delivery and integration of transgenes, and currently most clinical studies are using gamma retroviral or lentiviral systems. Whilst important proof-of-principle data has been generated for both chimeric antigen receptors and αβ T cell receptors, the current platforms are costly, time-consuming and relatively inflexible. Alternative, more cost-effective, Sleeping Beauty transposon-based plasmid systems could offer a pathway to accelerated clinical testing of a more diverse repertoire of recombinant high affinity T cell receptors. Nucleofection of hyperactive SB100X transposase-mediated stable transposition of an optimised murine-human chimeric T cell receptor specific for Wilm's tumour antigen from a Sleeping Beauty transposon plasmid. Whilst transfer efficiency was lower than that mediated by lentiviral transduction, cells could be readily enriched and expanded, and mediated effective target cells lysis in vitro and in vivo. Integration sites of transposed TCR genes in primary T cells were almost randomly distributed, contrasting the predilection of lentiviral vectors for transcriptionally active sites. The results support exploitation of the Sleeping Beauty plasmid based system as a flexible and adaptable platform for accelerated, early-phase assessment of T cell receptor gene therapies.

  4. RNA interference is responsible for reduction of transgene expression after Sleeping Beauty transposase mediated somatic integration.

    Directory of Open Access Journals (Sweden)

    Christina Rauschhuber

    Full Text Available BACKGROUND: Integrating non-viral vectors based on transposable elements are widely used for genetically engineering mammalian cells in functional genomics and therapeutic gene transfer. For the Sleeping Beauty (SB transposase system it was demonstrated that convergent transcription driven by the SB transposase inverted repeats (IRs in eukaryotic cells occurs after somatic integration. This could lead to formation of double-stranded RNAs potentially presenting targets for the RNA interference (RNAi machinery and subsequently resulting into silencing of the transgene. Therefore, we aimed at investigating transgene expression upon transposition under RNA interference knockdown conditions. PRINCIPAL FINDINGS: To establish RNAi knockdown cell lines we took advantage of the P19 protein, which is derived from the tomato bushy stunt virus. P19 binds and inhibits 21 nucleotides long, small-interfering RNAs and was shown to sufficiently suppress RNAi. We found that transgene expression upon SB mediated transposition was enhanced, resulting into a 3.2-fold increased amount of colony forming units (CFU after transposition. In contrast, if the transgene cassette is insulated from the influence of chromosomal position effects by the chicken-derived cHS4 insulating sequences or when applying the Forg Prince transposon system, that displays only negligible transcriptional activity, similar numbers of CFUs were obtained. CONCLUSION: In summary, we provide evidence for the first time that after somatic integration transposon derived transgene expression is regulated by the endogenous RNAi machinery. In the future this finding will help to further improve the molecular design of the SB transposase vector system.

  5. Epigenetics and therapeutic targets mediating neuroprotection.

    Science.gov (United States)

    Qureshi, Irfan A; Mehler, Mark F

    2015-12-02

    The rapidly evolving science of epigenetics is transforming our understanding of the nervous system in health and disease and holds great promise for the development of novel diagnostic and therapeutic approaches targeting neurological diseases. Increasing evidence suggests that epigenetic factors and mechanisms serve as important mediators of the pathogenic processes that lead to irrevocable neural injury and of countervailing homeostatic and regenerative responses. Epigenetics is, therefore, of considerable translational significance to the field of neuroprotection. In this brief review, we provide an overview of epigenetic mechanisms and highlight the emerging roles played by epigenetic processes in neural cell dysfunction and death and in resultant neuroprotective responses. This article is part of a Special Issue entitled SI: Neuroprotection.

  6. The Slaying of a Beautiful Hypothesis: The Efficacy of Counseling and the Therapeutic Process

    Science.gov (United States)

    Hauser, Mike; Hays, Danica G.

    2010-01-01

    Although the efficacy of counseling has been empirically linked to the therapeutic process, the emphasis in much of the literature remains on technique use. This article discusses 3 components of therapeutic efficacy (i.e., common factors, working alliance, and counselor attributes) and provides implications for counselors and counselor training.…

  7. Novel therapeutic approaches for various cancer types using a modified sleeping beauty-based gene delivery system.

    Science.gov (United States)

    Hong, In-Sun; Lee, Hwa-Yong; Kim, Hyun-Pyo

    2014-01-01

    Successful gene therapy largely depends on the selective introduction of therapeutic genes into the appropriate target cancer cells. One of the most effective and promising approaches for targeting tumor tissue during gene delivery is the use of viral vectors, which allow for high efficiency gene delivery. However, the use of viral vectors is not without risks and safety concerns, such as toxicities, a host immune response towards the viral antigens or potential viral recombination into the host's chromosome; these risks limit the clinical application of viral vectors. The Sleeping Beauty (SB) transposon-based system is an attractive, non-viral alternative to viral delivery systems. SB may be less immunogenic than the viral vector system due to its lack of viral sequences. The SB-based gene delivery system can stably integrate into the host cell genome to produce the therapeutic gene product over the lifetime of a cell. However, when compared to viral vectors, the non-viral SB-based gene delivery system still has limited therapeutic efficacy due to the lack of long-lasting gene expression potential and tumor cell specific gene transfer ability. These limitations could be overcome by modifying the SB system through the introduction of the hTERT promoter and the SV40 enhancer. In this study, a modified SB delivery system, under control of the hTERT promoter in conjunction with the SV40 enhancer, was able to successfully transfer the suicide gene (HSV-TK) into multiple types of cancer cells. The modified SB transfected cancer cells exhibited a significantly increased cancer cell specific death rate. These data suggest that our modified SB-based gene delivery system can be used as a safe and efficient tool for cancer cell specific therapeutic gene transfer and stable long-term expression.

  8. [Video games, a therapeutic mediator for teens].

    Science.gov (United States)

    Nickler, Christophe

    2015-10-01

    Teenagers love video games and other multimedia tools. Sometimes they love them too much, leading to addictive use. A child psychiatry team in Nancy has developed a therapeutic multimedia workshop to contribute to treating teens.

  9. Derivation and characterization of sleeping beauty transposon-mediated porcine induced pluripotent stem cells

    DEFF Research Database (Denmark)

    Kues, Wilfried A.; Herrmann, Doris; Barg-Kues, Brigitte

    2013-01-01

    the nonviral Sleeping Beauty transposon system to deliver the reprogramming factors Oct4, Sox2, Klf4, and cMyc. Successful reprogramming to a pluripotent state was indicated by changes in cell morphology and reactivation of the Oct4-EGFP reporter. The transposon-reprogrammed induced pluripotent stem (i...

  10. Derivation and characterization of sleeping beauty transposon-mediated porcine induced pluripotent stem cells

    DEFF Research Database (Denmark)

    Kues, Wilfried A.; Herrmann, Doris; Barg-Kues, Brigitte;

    2013-01-01

    the nonviral Sleeping Beauty transposon system to deliver the reprogramming factors Oct4, Sox2, Klf4, and cMyc. Successful reprogramming to a pluripotent state was indicated by changes in cell morphology and reactivation of the Oct4-EGFP reporter. The transposon-reprogrammed induced pluripotent stem (iPS...... of the 3 germ layers. Upon injection of putative iPS cells under the skin of immunodeficient mice, we observed teratomas in 3 of 6 cases. These results form the basis for in-depth studies toward the derivation of porcine iPS cells, which hold great promise for preclinical testing of novel cell therapies......The domestic pig is an important large animal model for preclinical testing of novel cell therapies. Recently, we produced pluripotency reporter pigs in which the Oct4 promoter drives expression of the enhanced green fluorescent protein (EGFP). Here, we reprogrammed Oct4-EGFP fibroblasts employing...

  11. Effective Expression-Independent Gene Trapping and Mutagenesis Mediated by Sleeping Beauty Transposon

    Institute of Scientific and Technical Information of China (English)

    Guili Song; Qing Li; Yong Long; Perry B. Hackett; Zongbin Cui

    2012-01-01

    Expression-independent gene or polyadenylation [poly(A)] trapping is a powerful tool for genome-wide mutagenesis regardless of whether a targeted gene is expressed.Although a number of poly(A)-trap vectors have been developed for the capture and mutation of genes across a vertebrate genome,further efforts are needed to avoid the 3′-terminal insertion bias and the splice donor (SD)read-through,and to improve the mutagenicity.Here,we present a Sleeping Beauty (SB) transposon-based vector that can overcome these limitations through the inclusion of three functional cassettes required for gene-finding,gene-breaking and large-scale mutagenesis,respectively.The functional cassette contained a reporter/selective marker gene driven by a constitutive promoter in front of a strong SD signal and an AU-rich RNA-destabilizing element (ARE),which greatly reduced the SD read-through events,except that the internal ribosomal entry site (IRES) element was introduced in front of the SD signal to overcome the phenomenon of 3′-bias gene trapping.The breaking cassette consisting of an enhanced splicing acceptor (SA),a poly(A) signal coupled with a transcriptional terminator (TT) effectively disrupted the transcription of trapped genes.Moreover,the Hsp70 promoter from tilapia genome was employed to drive the inducible expression of SB11,which allows the conditional remobilization of a trap insert from a non-coding region.The combination of three cassettes led to effective capture and disruption of endogenous genes in HeLa cells.In addition,the Cre/LoxP system was introduced to delete the Hsp70-SB11 cassette for stabilization of trapped gene interruption and biosafety.Thus,this poly(A)-trap vector is an alternative and effective tool for identification and mutation of endogenous genes in cells and animals.

  12. [Mechanism of mediators in human skin. Pharmacoanalysis and therapeutic aspects].

    Science.gov (United States)

    Stüttgen, G

    1977-06-01

    Under physiological and pathological conditions, the skin is influenced by tissue hormones (biogenic amines, kinines, prostaglandines), neuro-hormones (acetylcholine, catecholamines) and by proteins as complement. The combination of neurological stimulation with a series of self-propagating metabolic changes, shows new aspects of tissue reaction. Histamine triggers a serie of mediators as kinines and prostaglandines. Due to their influence on mediators and their effects on regulatory mechanisms the cyclic nucleotides can serve as model substances for the development of therapeutic processes for dermatological as well as for other disorders. The influence on mediator-systems by topical treatment and proven permeability of such substances is of extreme importance for the future development of local dermatological therapy.

  13. The medicalization of beauty

    Directory of Open Access Journals (Sweden)

    Paulo Poli Neto

    2007-01-01

    Full Text Available Concern with body image and medical interventions related to physical beauty has greatly increased in the past few years. The purpose of this study is to investigate how medicine is dealing with the theme of beauty. The 2003/2004 editions of the periodicals Aesthetic Surgery Journal and Aesthetic Plastic Surgery were analyzed, in order to investigate the rationality buttressing their discourse. Three categories were prioritized for this study: definition of aesthetic plastic surgery's study object; beauty patterns guiding interventions; and understanding popular demand for aesthetic corrections. Discourse is sustained by biomedical rationality, structured around a disease theory and a dual construction between normal and pathological, with emphasis on biology. In the articles, the beauty patterns guiding therapeutic practices are anchored in biological norms defined through several anthropometric measures, which refer to abstract concepts of beauty, harmony, proportionality and symmetry. In this discourse, there are no references to patterns or to social norms of beauty; motivation for aesthetic intervention appears to be rooted in low self-esteem related to the aging process or to some bodily nonconformity. As per the meaning of 'medicalization' adopted herein, biomedical rationality appropriates variations or anomalies of physical appearance, thus allowing the theme to be dealt with in terms of health and disease, normal and pathological.

  14. Beauty Redeemed

    DEFF Research Database (Denmark)

    Braae, Ellen Marie

    /PROAP’s Parque do Tejo e Trancão in Lisbon and Michel Desvigne’s Parc aux Angéliques in Bordeaux. Beauty Redeemed offers a systematic framework for the consideration and use of post-industrial sites. The author, Professor of Landscape Design at Copenhagen University, places these ‘leftovers’ in their broad......; it explores design work informed by a sensibility for redeemed beauty and various concepts of relating past, present and future...

  15. Lung Regeneration: Endogenous and Exogenous Stem Cell Mediated Therapeutic Approaches.

    Science.gov (United States)

    Akram, Khondoker M; Patel, Neil; Spiteri, Monica A; Forsyth, Nicholas R

    2016-01-19

    The tissue turnover of unperturbed adult lung is remarkably slow. However, after injury or insult, a specialised group of facultative lung progenitors become activated to replenish damaged tissue through a reparative process called regeneration. Disruption in this process results in healing by fibrosis causing aberrant lung remodelling and organ dysfunction. Post-insult failure of regeneration leads to various incurable lung diseases including chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis. Therefore, identification of true endogenous lung progenitors/stem cells, and their regenerative pathway are crucial for next-generation therapeutic development. Recent studies provide exciting and novel insights into postnatal lung development and post-injury lung regeneration by native lung progenitors. Furthermore, exogenous application of bone marrow stem cells, embryonic stem cells and inducible pluripotent stem cells (iPSC) show evidences of their regenerative capacity in the repair of injured and diseased lungs. With the advent of modern tissue engineering techniques, whole lung regeneration in the lab using de-cellularised tissue scaffold and stem cells is now becoming reality. In this review, we will highlight the advancement of our understanding in lung regeneration and development of stem cell mediated therapeutic strategies in combating incurable lung diseases.

  16. Lung Regeneration: Endogenous and Exogenous Stem Cell Mediated Therapeutic Approaches

    Directory of Open Access Journals (Sweden)

    Khondoker M. Akram

    2016-01-01

    Full Text Available The tissue turnover of unperturbed adult lung is remarkably slow. However, after injury or insult, a specialised group of facultative lung progenitors become activated to replenish damaged tissue through a reparative process called regeneration. Disruption in this process results in healing by fibrosis causing aberrant lung remodelling and organ dysfunction. Post-insult failure of regeneration leads to various incurable lung diseases including chronic obstructive pulmonary disease (COPD and idiopathic pulmonary fibrosis. Therefore, identification of true endogenous lung progenitors/stem cells, and their regenerative pathway are crucial for next-generation therapeutic development. Recent studies provide exciting and novel insights into postnatal lung development and post-injury lung regeneration by native lung progenitors. Furthermore, exogenous application of bone marrow stem cells, embryonic stem cells and inducible pluripotent stem cells (iPSC show evidences of their regenerative capacity in the repair of injured and diseased lungs. With the advent of modern tissue engineering techniques, whole lung regeneration in the lab using de-cellularised tissue scaffold and stem cells is now becoming reality. In this review, we will highlight the advancement of our understanding in lung regeneration and development of stem cell mediated therapeutic strategies in combating incurable lung diseases.

  17. Cell mediated therapeutics for cancer treatment: Tumor homing cells as therapeutic delivery vehicles

    Science.gov (United States)

    Balivada, Sivasai

    Many cell types were known to have migratory properties towards tumors and different research groups have shown reliable results regarding cells as delivery vehicles of therapeutics for targeted cancer treatment. Present report discusses proof of concept for 1. Cell mediated delivery of Magnetic nanoparticles (MNPs) and targeted Magnetic hyperthermia (MHT) as a cancer treatment by using in vivo mouse cancer models, 2. Cells surface engineering with chimeric proteins for targeted cancer treatment by using in vitro models. 1. Tumor homing cells can carry MNPs specifically to the tumor site and tumor burden will decrease after alternating magnetic field (AMF) exposure. To test this hypothesis, first we loaded Fe/Fe3O4 bi-magnetic NPs into neural progenitor cells (NPCs), which were previously shown to migrate towards melanoma tumors. We observed that NPCs loaded with MNPs travel to subcutaneous melanoma tumors. After alternating magnetic field (AMF) exposure, the targeted delivery of MNPs by the NPCs resulted in a mild decrease in tumor size (Chapter-2). Monocytes/macrophages (Mo/Ma) are known to infiltrate tumor sites, and also have phagocytic activity which can increase their uptake of MNPs. To test Mo/Ma-mediated MHT we transplanted Mo/Ma loaded with MNPs into a mouse model of pancreatic peritoneal carcinomatosis. We observed that MNP-loaded Mo/Ma infiltrated pancreatic tumors and, after AMF treatment, significantly prolonged the lives of mice bearing disseminated intraperitoneal pancreatic tumors (Chapter-3). 2. Targeted cancer treatment could be achieved by engineering tumor homing cell surfaces with tumor proteases cleavable, cancer cell specific recombinant therapeutic proteins. To test this, Urokinase and Calpain (tumor specific proteases) cleavable; prostate cancer cell (CaP) specific (CaP1 targeting peptide); apoptosis inducible (Caspase3 V266ED3)- rCasp3V266ED3 chimeric protein was designed in silico. Hypothesized membrane anchored chimeric protein (rCasp3V

  18. Nonlinear pharmacokinetics of therapeutic proteins resulting from receptor mediated endocytosis.

    Science.gov (United States)

    Krippendorff, Ben-Fillippo; Kuester, Katharina; Kloft, Charlotte; Huisinga, Wilhelm

    2009-06-01

    Receptor mediated endocytosis (RME) plays a major role in the disposition of therapeutic protein drugs in the body. It is suspected to be a major source of nonlinear pharmacokinetic behavior observed in clinical pharmacokinetic data. So far, mostly empirical or semi-mechanistic approaches have been used to represent RME. A thorough understanding of the impact of the properties of the drug and of the receptor system on the resulting nonlinear disposition is still missing, as is how to best represent RME in pharmacokinetic models. In this article, we present a detailed mechanistic model of RME that explicitly takes into account receptor binding and trafficking inside the cell and that is used to derive reduced models of RME which retain a mechanistic interpretation. We find that RME can be described by an extended Michaelis-Menten model that accounts for both the distribution and the elimination aspect of RME. If the amount of drug in the receptor system is negligible a standard Michaelis-Menten model is capable of describing the elimination by RME. Notably, a receptor system can efficiently eliminate drug from the extracellular space even if the total number of receptors is small. We find that drug elimination by RME can result in substantial nonlinear pharmacokinetics. The extent of nonlinearity is higher for drug/receptor systems with higher receptor availability at the membrane, or faster internalization and degradation of extracellular drug. Our approach is exemplified for the epidermal growth factor receptor system.

  19. Beautiful Flowers

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    春天到了,百花盛开,我们常说“美丽的鲜花”,就是:beautiful flowers。是不是觉得这两个单词有点儿难记呢?没关系,来玩玩我们的进宫吧,它能帮助你牢牢记住这两个单词的拼法。

  20. Beautiful geometry

    CERN Document Server

    Maor, Eli

    2014-01-01

    If you've ever thought that mathematics and art don't mix, this stunning visual history of geometry will change your mind. As much a work of art as a book about mathematics, Beautiful Geometry presents more than sixty exquisite color plates illustrating a wide range of geometric patterns and theorems, accompanied by brief accounts of the fascinating history and people behind each. With artwork by Swiss artist Eugen Jost and text by acclaimed math historian Eli Maor, this unique celebration of geometry covers numerous subjects, from straightedge-and-compass constructions to intriguing configur

  1. Carbon nanotubes as cancer therapeutic carriers and mediators

    Science.gov (United States)

    Son, Kuk Hui; Hong, Jeong Hee; Lee, Jin Woo

    2016-01-01

    Carbon nanotubes (CNTs) have received increasing attention in biomedical fields because of their unique structures and properties, including high aspect ratios, large surface areas, rich surface chemical functionalities, and size stability on the nanoscale. Particularly, they are attractive as carriers and mediators for cancer therapy. Through appropriate functionalization, CNTs have been used as nanocarriers for anticancer drugs including doxorubicin, camptothecin, carboplatin, cisplatin, paclitaxel, Pt(II), and Pt(IV), and genes including plasmid DNA, small-interfering RNA, oligonucleotides, and RNA/DNA aptamers. CNTs can also deliver proteins and immunotherapy components. Using combinations of light energy, they have also been applied as mediators for photothermal therapy and photodynamic therapy to directly destroy cancer cells without severely damaging normal tissue. If limitations such as a long-term cytotoxicity in the body, lack of size uniformity during the synthetic process, loading deviations for drug–CNT complexes, and release controllability at the target point are overcome, CNTs will become one of the strongest tools that are available for various other biomedical fields as well as for cancer therapy. PMID:27785021

  2. New insights and therapeutics for immune-mediated thrombocytopenia.

    Science.gov (United States)

    Metjian, Ara; Abrams, Charles S

    2008-01-01

    In recent years, great advances have been made in elucidating the pathogenesis of thrombocytopenia and the mechanisms of thrombopoiesis. Drawing upon decades of basic science and clinical research, the pathways behind the immune-mediated destruction of platelets have opened new avenues. This has led to the application of safer and more efficacious immunosuppressive agents, such as the anti-CD20 monoclonal antibody rituximab, or potentially altering the co-stimulatory pathways of the immune system with an anti-CD40L (CD154) monoclonal antibody. This has been coupled with the discoveries of the genetic and molecular pathways in thrombopoiesis, including the identification and cloning of thrombopoietin (TPO) and its receptor. The use of recombinant TPO, such as PEG-rHuMGDF and rhTPO, to treat thrombocytopenia have paved the way for alternative peptidyl and nonpeptidyl thrombopoietic agents that are considered to be nonimmunogenic. Those that have undergone evaluation in humans include the Amgen megakaryopoiesis protein (AMG) 531 compound, eltrombopag, and AKR-501. Additional TPO mimetics show promise in vitro and await future development.

  3. Targeting CD47-SIRPα interactions for potentiating therapeutic antibody-mediated tumor cell destruction by phagocytes

    NARCIS (Netherlands)

    Zhao, X.W.

    2014-01-01

    The primary aim of the studies described in this thesis was to investigate the role of CD47-SIRPα interactions in therapeutic antibody-dependent tumor cell destruction by human phagocytes and also explore the killing mechanism(s) by which human phagocytes, and in particular human neutrophils, mediat

  4. The Real Beauty

    Institute of Scientific and Technical Information of China (English)

    胡晓媛

    2015-01-01

    it is well-known that all men search for beauty. Although the definition of beauty changes as time goes by,people still spare no efforts to pursue beauty in their lives. Meanwhile,most people try every means to make their body images better.With more people increasingly being eager for beauty in various ways,it is high time that we should think deeply about the concept of real beauty.Inthis paper,an attempt has been made to shed light on the real beauty.It is not completely physical appearance or slim figure,but a healthy body and peaceful mind as well as admirable courage.Above all,whether people can realize the nature of real beauty is certainly worthwhile for us to ponder.

  5. The Real Beauty

    Institute of Scientific and Technical Information of China (English)

    胡晓媛

    2015-01-01

    it is well-known that all men search for beauty.Although the definition of beauty changes as time goes by,people still spare no efforts to pursue beauty in their lives.Meanwhile,most people try every means to make their body images better.With more people increasingly being eager for beauty in various ways,it is high time that we should think deeply about the concept of real beauty.In this paper,an attempt has been made to shed light on the real beauty.It is not completely physical appearance or slim figure,but a healthy body and peaceful mind as well as admirable courage.Above all,whether people can realize the nature of real beauty is certainly worthwhile for us to ponder.

  6. TLR-mediated NF-kB-dependent cytokine production is differently affected by HIV therapeutics

    DEFF Research Database (Denmark)

    Melchjorsen, Jesper; Paludan, Søren Riis; Mogensen, Trine

      Pathogen-recognizing Toll-like receptors 2 (TLR2) and TLR4 are known to recognize a number of pathogens, including E.Coli, S. Pneumonia and N. Meningococcus. We have studied whether a number of HIV therapeutics affect immediate proinflammatory cytokine responses in cell cultures. Preliminary...... results suggest an opposing effect of the drugs Tenofovir and Retrovir (AZT) on TLR-mediated production of NF-kappaB-dependent proinflammatory cytokines. We present data on the mechanisms behind the drug-mediated remodeling of innate immune activation and how the drugs effect early host...

  7. Beauty in the Breakdown

    Science.gov (United States)

    Brisco, Nicole

    2008-01-01

    Most human beings look at erosion as the destruction of a surface, but artists can see that erosion often creates indefinable beauty. Where do you see beauty in the breakdown? In this article, the author presents an innovative lesson that would allow students to observe both human and physical nature. In this activity students will create a work…

  8. Musings about Beauty

    Science.gov (United States)

    Kintsch, Walter

    2012-01-01

    In this essay, I explore how cognitive science could illuminate the concept of beauty. Two results from the extensive literature on aesthetics guide my discussion. As the term "beauty" is overextended in general usage, I choose as my starting point the notion of "perfect form." Aesthetic theorists are in reasonable agreement about the criteria for…

  9. Hypoxia-Inducible Factors: Mediators of Cancer Progression; Prognostic and Therapeutic Targets in Soft Tissue Sarcomas

    Energy Technology Data Exchange (ETDEWEB)

    Sadri, Navid; Zhang, Paul J., E-mail: pjz@mail.med.upenn.edu [Anatomic Pathology, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, 3400 Spruce Street, 6th Floor Founders Building, Philadelphia, PA 19104 (United States)

    2013-04-02

    Soft-tissue sarcomas remain aggressive tumors that result in death in greater than a third of patients due to either loco-regional recurrence or distant metastasis. Surgical resection remains the main choice of treatment for soft tissue sarcomas with pre- and/or post-operational radiation and neoadjuvant chemotherapy employed in more advanced stage disease. However, in recent decades, there has been little progress in the average five-year survival for the majority of patients with high-grade soft tissue sarcomas, highlighting the need for improved targeted therapeutic agents. Clinical and preclinical studies demonstrate that tumor hypoxia and up-regulation of hypoxia-inducible factors (HIFs) is associated with decreased survival, increased metastasis, and resistance to therapy in soft tissue sarcomas. HIF-mediated gene expression regulates many critical aspects of tumor biology, including cell survival, metabolic programming, angiogenesis, metastasis, and therapy resistance. In this review, we discuss HIFs and HIF-mediated genes as potential prognostic markers and therapeutic targets in sarcomas. Many pharmacological agents targeting hypoxia-related pathways are in development that may hold therapeutic potential for treating both primary and metastatic sarcomas that demonstrate increased HIF expression.

  10. AIF-mediated caspase-independent necroptosis: a new chance for targeted therapeutics.

    Science.gov (United States)

    Delavallée, Laure; Cabon, Lauriane; Galán-Malo, Patricia; Lorenzo, Hans K; Susin, Santos A

    2011-04-01

    Cell death has been initially divided into apoptosis, in which the cell plays an active role, and necrosis, which is considered a passive cell death program. Intense research performed in the last decades has concluded that "programmed" cell death (PCD) is a more complex physiological process than initially thought. Indeed, although in most cases the PCD process is achieved via a family of Cys proteases known as caspases, an important number of regulated PCD pathways do not involve this family of proteases. As a consequence, active forms of PCD are initially referred to as caspase-dependent and caspase-independent. More recent data has revealed that there are also active caspase-independent necrotic pathways defined as necroptosis (programmed necrosis). The existence of necroptotic forms of death was corroborated by the discovery of key executioners such as the kinase RIP1 or the mitochondrial protein apoptosis-inducing factor (AIF). AIF is a Janus protein with a redox activity in the mitochondria and a pro-apoptotic function in the nucleus. We have recently described a particular form of AIF-mediated caspase-independent necroptosis that also implicates other molecules such as PARP-1, calpains, Bax, Bcl-2, histone H2AX, and cyclophilin A. From a therapeutic point of view, the unraveling of this new form of PCD poses a question: is it possible to modulate this necroptotic pathway independently of the classical apoptotic paths? Because the answer is yes, a wider understanding of AIF-mediated necroptosis could theoretically pave the way for the development of new drugs that modulate PCD. To this end, we present here an overview of the current knowledge of AIF and AIF-mediated necroptosis. We also summarize the state of the art in some of the most interesting therapeutic strategies that could target AIF or the AIF-mediated necroptotic pathway.

  11. Neural correlates of beauty.

    Science.gov (United States)

    Kawabata, Hideaki; Zeki, Semir

    2004-04-01

    We have used the technique of functional MRI to address the question of whether there are brain areas that are specifically engaged when subjects view paintings that they consider to be beautiful, regardless of the category of painting (that is whether it is a portrait, a landscape, a still life, or an abstract composition). Prior to scanning, each subject viewed a large number of paintings and classified them into beautiful, neutral, or ugly. They then viewed the same paintings in the scanner. The results show that the perception of different categories of paintings are associated with distinct and specialized visual areas of the brain, that the orbito-frontal cortex is differentially engaged during the perception of beautiful and ugly stimuli, regardless of the category of painting, and that the perception of stimuli as beautiful or ugly mobilizes the motor cortex differentially.

  12. Beauty in chemistry

    Directory of Open Access Journals (Sweden)

    Peter Atkins

    2006-03-01

    Full Text Available Though hard going for the general reader and highly personal in its selectivity, Elegant Solutions: Ten Beautiful Experiments in Chemistry provides reflections of a thoughtful author that will delight chemists

  13. Black Hair is Beautiful

    Institute of Scientific and Technical Information of China (English)

    1994-01-01

    On June 9, the 1994 ⅩⅢ Asian Make-up and Hairstyling Competition was held in Beijing. More than 200 contestants from 12 countries and regions across Asia participated. The competition is now considered the largest and most prestigious exchange activity in Asian beauty and hair circles. Black Hair is Beautiful" was the theme of this competition, which stressed Asian physical characteristics and aesthetics.

  14. What Is Beauty?

    Institute of Scientific and Technical Information of China (English)

    胡应余

    2007-01-01

    <正> It seems that beauty and women are twins. You are joking? No, I am not. Observe for yourself. Ads on fashion flood TV screens, radio programs, magazines, newspapers, and the streets. Whether they have realized or not, women are besieged by a sea of fashions. They are taught to think that without beautiful clothes they will grow old and lose their charm. So who dares to neglect dressing up at the cost of their appearance and youth?

  15. Inflammatory Mediators and Angiogenic Factors in Choroidal Neovascularization: Pathogenetic Interactions and Therapeutic Implications

    Directory of Open Access Journals (Sweden)

    Claudio Campa

    2010-01-01

    Full Text Available Choroidal neovascularization (CNV is a common and severe complication in heterogeneous diseases affecting the posterior segment of the eye, the most frequent being represented by age-related macular degeneration. Although the term may suggest just a vascular pathological condition, CNV is more properly definable as an aberrant tissue invasion of endothelial and inflammatory cells, in which both angiogenesis and inflammation are involved. Experimental and clinical evidences show that vascular endothelial growth factor is a key signal in promoting angiogenesis. However, many other molecules, distinctive of the inflammatory response, act as neovascular activators in CNV. These include fibroblast growth factor, transforming growth factor, tumor necrosis factor, interleukins, and complement. This paper reviews the role of inflammatory mediators and angiogenic factors in the development of CNV, proposing pathogenetic assumptions of mutual interaction. As an extension of this concept, new therapeutic approaches geared to have an effect on both the vascular and the extravascular components of CNV are discussed.

  16. Studies on nonsense mediated decay reveal novel therapeutic options for genetic diseases.

    Science.gov (United States)

    Bashyam, Murali D

    2009-01-01

    Scientific breakthroughs have often led to commercially viable patents mainly in the field of engineering. Commercialization in the field of medicine has been restricted mostly to machinery and engineering on the one hand and therapeutic drugs for common chronic ailments such as cough, cold, headache, etc, on the other. Sequencing of the human genome has attracted the attention of pharmaceutical companies and now biotechnology has become a goldmine for commercialization of products and processes. Recent advances in our understanding of basic biological processes have resulted in the opening of new avenues for treatment of human genetic diseases, especially single gene disorders. A significant proportion of human genetic disorders have been shown to be caused due to degradation of transcripts for specific genes through a process called nonsense mediated decay (NMD). The modulation of NMD provides a viable therapeutic option for treatment of several genetic disorders and therefore has been a good prospect for patenting and commercialization. In this review the molecular basis for NMD and attempts to treat genetic diseases which result from NMD are discussed.

  17. Implantable Loop Recorder: Diagnostic Yield And Possible Therapeutic Effect In Patients With Neurally Mediated Reflex Syncope.

    Science.gov (United States)

    M, Unterhuber; W, Rauhe; P, Sgobino; F, Pescoller; M, Manfrin; M, Tomaino

    2016-01-01

    Through a retrospective study concerning the experience of our center in patients affected by Neurally Mediated reflex Syncope (NMS) we wanted to verify not only the diagnostic yield of the Implantable Loop Recorder (ILR) but its possible placebo therapeutic effect. In the context of patients affected by a severe clinical presentation of NMS identified through a careful clinical evaluation, we selected those who followed a diagnostic iter using the ILR. We analysed 84 patients (39 male and 45 female, mean age 71 years), during the period 2009-2013. 34 patients (40.5%) had no recurrences after a mean follow-up (FU) of 35 months, among these 17 concluded a FU of 4 years. 50 patients (59.5%) had recurrences and a specific diagnosis after an average period of 7 months. We found an important number of patients who showed a disappearance of syncope during an observation period of 2-3 and 4 years. At first glance this results could be explained considering the possible placebo therapeutic effect of ILR.

  18. Therapeutic advances and future prospects in immune-mediated inflammatory myopathies.

    Science.gov (United States)

    Dalakas, Marinos C

    2008-11-01

    THE INFLAMMATORY MYOPATHIES INCLUDE THREE DISTINCT ENTITIES: polymyositis (PM), dermatomyositis (DM), and inclusion body myositis (IBM). A T-cell-mediated cytotoxic process in PM and IBM and a complement-mediated microangiopathy in DM are the hallmarks of the underlying autoimmune processes. The most consistent therapeutic problem remains the distinction of PM from the difficult-to-treat mimics such as s-IBM, necrotizing myopathies and inflammatory dystrophies. This review provides a step-by-step approach to the treatment of inflammatory myopathies, highlights the common pitfalls and mistakes in therapy, and identifies the emerging new therapies. In uncontrolled studies, PM and DM respond to prednisone to some degree and for some period of time, while a combination with one immu-nosuppressive drug (azathioprine, cyclosporine, mycophenolate, methotrexate) offers additional benefit or steroid-sparing effect. In contrast, IBM is resistant to most of these therapies, most of the time. Controlled studies have shown that IVIg is effective and safe for the treatment of DM, where is used as a second, and at times first, line therapy. IVIg seems to be also effective in the majority of patients with PM based on uncontrolled series, but it offers transient help to a small number of patients with IBM especially those with dysphagia. Bona fide patients with PM and DM who become resistant to the aforementioned therapies, may respond to rituximab, tacrolimus or rarely to an tumor necrosis factor alpha inhibitor. For IBM patients, experience with alemtuzumab, a T-cell-depleting monoclonal antibody, is encouraging.

  19. Therapeutic potential of bacteriophage in treating Klebsiella pneumoniae B5055-mediated lobar pneumonia in mice.

    Science.gov (United States)

    Chhibber, Sanjay; Kaur, Sandeep; Kumari, Seema

    2008-12-01

    Klebsiella pneumoniae causes infections in humans especially in immunocompromised patients. About 80 % of nosocomial infections caused by K. pneumoniae are due to multidrug-resistant strains. The emergence of antibiotic-resistant bacterial strains necessitates the exploration of alternative antibacterial therapies, which led our group to study the ability of bacterial viruses (known as bacteriophages or simply phages) to treat mice challenged with K. pneumoniae. Phage SS specific for K. pneumoniae B5055 was isolated and characterized, and its potential as a therapeutic agent was evaluated in an experimental model of K. pneumoniae-mediated lobar pneumonia in mice. Mice were challenged by intranasal (i.n.) inoculation with bacteria (10(8) c.f.u. ml(-1)). A single intraperitoneal injection of 10(10) p.f.u. ml(-1) phage administered immediately after i.n. challenge was sufficient to rescue 100 % of animals from K. pneumoniae-mediated respiratory infections. Administration of the phage preparation 3 h prior to i.n. bacterial challenge provided significant protection in infected mice, while even 6 h delay of phage administration after the induction of infection rendered the phage treatment ineffective. The results of this study therefore suggest that the timing of starting the phage therapy after initiation of infection significantly contributes towards the success of the treatment.

  20. Why Landscape Beauty Matters

    Directory of Open Access Journals (Sweden)

    Angelika Krebs

    2014-11-01

    Full Text Available This philosophical paper explores the aesthetic argument for landscape conservation. The main claim is that the experience of beautiful landscapes is an essential part of the good human life. Beautiful landscapes make us feel at home in the world. Their great and irreplaceable value lies therein. To establish this claim, the concepts of landscape and “Stimmung” are clarified. It is shown how “Stimmung” (in the sense of mood is infused into landscape (as atmosphere and how we respond to it aesthetically. We respond by resonating or feeling at home. The paper ends by indicating how art can help us to better appreciate landscape beauty. This is done by way of an example from contemporary nature poetry, Michael Donhauser’s Variationen in Prosa, which begins with “Und was da war, es nahm uns an” (“And what was there accepted us”.

  1. Introduction to Beautiful Soup

    Directory of Open Access Journals (Sweden)

    Jeri Wieringa

    2012-12-01

    Full Text Available Beautiful Soup is a Python library for getting data out of HTML, XML, and other markup languages. Say you’ve found some webpages that display data relevant to your research, such as date or address information, but that do not provide any way of downloading the data directly. Beautiful Soup helps you pull particular content from a webpage, remove the HTML markup, and save the information. It is a tool for web scraping that helps you clean up and parse the documents you have pulled down from the web.

  2. Who Engages with Moral Beauty?

    Science.gov (United States)

    Diessner, Rhett; Iyer, Ravi; Smith, Meghan M.; Haidt, Jonathan

    2013-01-01

    Aristotle considered moral beauty to be the "telos" of the human virtues. Displays of moral beauty have been shown to elicit the moral emotion of elevation and cause a desire to become a better person and to engage in prosocial behavior. Study 1 ("N" = 5380) shows engagement with moral beauty is related to several psychological…

  3. "Soccer": The Beautiful Game

    Science.gov (United States)

    Spires, Todd

    2008-01-01

    Soccer, or football as it is called in the rest of the world, is the most popular and fastest-growing global sport, with an estimated 240 million people regularly playing what Brazilian star Pele called "the beautiful game." Millions, worldwide, watch it on television. In 2006, the average viewership for each match of the month-long World Cup was…

  4. The Trend of Beauty

    Institute of Scientific and Technical Information of China (English)

    LINDA; LEE

    1995-01-01

    EVER since ancient times Shanghai people have pursued beauty. The Shanghai History Museum, mounted an exhibition entitled "Spectacular Garments, Cultural Relics and Documents of Modern Shanghai" which certainly proved this point. This exhibit showed that throughout Shanghai’s long history, dress and personal adomment have been important to the residents. During the twentieth

  5. My Beautiful Friend

    Institute of Scientific and Technical Information of China (English)

    雷全

    2004-01-01

    I have many toys in my room.Al-though they can’t speak,I treat them asmy friends.I like playing with them.Among them,my favorite is the beautiful girl-Barbiedoll.Her name is Kelly,same as my English name.She cameto my family a year ago as my birthday gift.

  6. Elevated pressure, a novel cancer therapeutic tool for sensitizing cisplatin-mediated apoptosis in A549

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Sangnam [Cellular and Developmental Biology, Division of Biomedical Science, College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of); Department of Preventive Medicine and Medical Research Center for Environmental Toxico-Genomics and Proteomics, College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of); Kim, Yanghee [Department of Preventive Medicine and Medical Research Center for Environmental Toxico-Genomics and Proteomics, College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of); Kim, Joonhee [Cellular and Developmental Biology, Division of Biomedical Science, College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of); Department of Preventive Medicine and Medical Research Center for Environmental Toxico-Genomics and Proteomics, College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of); Kwon, Daeho [Department of Preventive Medicine and Medical Research Center for Environmental Toxico-Genomics and Proteomics, College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of); Lee, Eunil, E-mail: eunil@korea.ac.kr [Cellular and Developmental Biology, Division of Biomedical Science, College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of); Department of Preventive Medicine and Medical Research Center for Environmental Toxico-Genomics and Proteomics, College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of)

    2010-08-13

    Research highlights: {yields} Sensitized apoptosis in cancer cells stimulated by EP precondition with p53 dependence. {yields} EP attenuates several CDDP-resistance mechanisms. {yields} No harmful effect of EP on normal fibroblasts. -- Abstract: Intensive cancer therapy strategies have thus far focused on sensitizing cancer cells to anticancer drug-mediated apoptosis to overcome drug resistance, and this strategy has led to more effective cancer therapeutics. Cisplatin (cis-diamminedichloroplatinum(II), CDDP) is an effective anticancer drug used to treat many types of cancer, including non-small cell lung carcinoma (NSCLC), and can be used in combination with various chemicals to enhance cancer cell apoptosis. Here, we introduce the use of elevated pressure (EP) in combination with CDDP for cancer treatment and explore the effects of EP on CDDP-mediated apoptosis in NSCLC cells. Our findings demonstrate that preconditioning NSCLC cells with EP sensitizes cells for CDDP-induced apoptosis. Enhanced apoptosis was dependent on p53 and HO-1 expression, and was associated with increased DNA damage and down-regulation of genes involved in nucleotide excision repair. The transcriptional levels of transporter proteins indicated that the mechanism by which EP-induced CDDP sensitization was intracellular drug accumulation. The protein levels of some antioxidants, such as hemeoxygenase-1 (HO-1), glutathione (GSH) and glutathione peroxidase (Gpx), were decreased in A549 cells exposed to EP via the down-regulation of the transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf-2). Furthermore, normal human fibroblasts were resistant to EP treatment, with no elevated DNA damage or apoptosis. Collectively, these data show that administration of EP is a potential adjuvant tool for CDDP-based chemosensitivity of lung cancer cells that may reduce drug resistance.

  7. Scutellarin attenuates microglia-mediated neuroinflammation and promotes astrogliosis in cerebral ischemia - a therapeutic consideration

    Science.gov (United States)

    Wu, Chun-Yun; Fang, Ming; Karthikeyan, Aparna; Yuan, Yun; Ling, Eng-Ang

    2016-11-18

    Neuroinflammation plays an important role in different brain diseases including acute brain injuries such as cerebral ischemic stroke and chronic neurodegenerative diseases e.g. Alzheimer's disease etc. The central player in this is the activated microglia which produce substantial amounts of proinflammatory mediators that may exacerbate the disease. Associated with microglia activation is astrogliosis characterized by hypertrophic astrocytes with increased expression of proinflammatory cytokines, neurotrophic factors, stem cell, neuronal and proliferation markers, all these are crucial for reconstruction of damaged tissue and ultimate restoration of neurological functions. Here, we review the roles of activated microglia and reactive astrocytes in brain diseases with special reference to cerebral ischemia, and the effects of scutellarin, a Chinese herbal extract on both glial cells. We first reviewed the close spatial relation between activated microglia and reactive astrocytes as it suggests that both glial cells work in concert for tissue reconstruction and repair. Secondly, we have identified scutellarin as a putative therapeutic agent as it has been found to not only suppress microglial activation thus ameliorating neuroinflammation, but also enhance astrocytic reaction. In the latter, scutellarin amplified the astrocytic reaction by upregulating the expression of neurotrophic factors among others thus indicating its neuroprotective role. Remarkably, the effects of scutellarin on reactive astrocytes were mediated by activated microglia supporting a functional "cross-talk" between the two glial types. This review highlights some of our recent findings taking into consideration of others demonstrating the beneficial effects of scutellarin on both glial cell types in cerebral ischemia as manifested by improvement of neurological functions.

  8. Gene therapy-mediated delivery of targeted cytotoxins for glioma therapeutics.

    Science.gov (United States)

    Candolfi, Marianela; Xiong, Weidong; Yagiz, Kader; Liu, Chunyan; Muhammad, A K M G; Puntel, Mariana; Foulad, David; Zadmehr, Ali; Ahlzadeh, Gabrielle E; Kroeger, Kurt M; Tesarfreund, Matthew; Lee, Sharon; Debinski, Waldemar; Sareen, Dhruv; Svendsen, Clive N; Rodriguez, Ron; Lowenstein, Pedro R; Castro, Maria G

    2010-11-16

    Restricting the cytotoxicity of anticancer agents by targeting receptors exclusively expressed on tumor cells is critical when treating infiltrative brain tumors such as glioblastoma multiforme (GBM). GBMs express an IL-13 receptor (IL13Rα2) that differs from the physiological IL4R/IL13R receptor. We developed a regulatable adenoviral vector (Ad.mhIL-4.TRE.mhIL-13-PE) encoding a mutated human IL-13 fused to Pseudomonas exotoxin (mhIL-13-PE) that specifically binds to IL13Rα2 to provide sustained expression, effective anti-GBM cytotoxicity, and minimal neurotoxicity. The therapeutic Ad also encodes mutated human IL-4 that binds to the physiological IL4R/IL13R without interacting with IL13Rα2, thus inhibiting potential binding of mhIL-13-PE to normal brain cells. Using intracranial GBM xenografts and syngeneic mouse models, we tested the Ad.mhIL-4.TRE.mhIL-13-PE and two protein formulations, hIL-13-PE used in clinical trials (Cintredekin Besudotox) and a second-generation mhIL-13-PE. Cintredekin Besudotox doubled median survival without eliciting long-term survival and caused severe neurotoxicity; mhIL-13-PE led to ∼40% long-term survival, eliciting severe neurological toxicity at the high dose tested. In contrast, Ad-mediated delivery of mhIL-13-PE led to tumor regression and long-term survival in over 70% of the animals, without causing apparent neurotoxicity. Although Cintredekin Besudotox was originally developed to target GBM, when tested in a phase III trial it failed to achieve clinical endpoints and revealed neurotoxicity. Limitations of Cintredekin Besudotox include its short half-life, which demanded frequent or continued administration, and binding to IL4R/IL13R, present in normal brain cells. These shortcomings were overcome by our therapeutic Ad, thus representing a significant advance in the development of targeted therapeutics for GBM.

  9. Mechanisms of a novel anticancer therapeutic strategy involving atmospheric pressure plasma-mediated apoptosis and DNA strand break formation.

    Science.gov (United States)

    Chung, Woo-Hyun

    2016-01-01

    Atmospheric pressure plasma has been developed for a variety of biomedical applications due to its chemically reactive components. Recently, the plasma has emerged as a promising novel cancer therapy based on its ability to selectively ablate cancer cells while leaving normal cells essentially unaffected. The therapeutic effect of plasma is attributed to intracellular generation of reactive oxygen/nitrogen species (ROS/RNS) leading to mitochondria-mediated apoptosis and to activation of the DNA damage checkpoint signaling pathway via severe DNA strand break formation. However, the biochemical mechanisms responsible for appropriate activation of these physiological events and which pathway is more crucial for plasma-mediated cytotoxicity have not been clarified. Understanding the molecular link between ROS/RNS-mediated apoptosis and DNA damage-involved chromosome instability is critical for the development of more efficacious therapeutic strategies for selective killing of diverse cancer cells.

  10. Polyethylenimine-mediated gene delivery to the lung and therapeutic applications

    Directory of Open Access Journals (Sweden)

    Sante Di Gioia

    2008-09-01

    Full Text Available Sante Di Gioia, Massimo ConeseDepartment of Biomedical Sciences, University of Foggia, Foggia, ItalyAbstract: Nonviral gene delivery is now considered a promising alternative to viral vectors. Among nonviral gene delivery agents, polyethylenimine (PEI has emerged as a potent candidate for gene delivery to the lung. PEI has some advantages over other polycations in that it combines strong DNA compaction capacity with an intrinsic endosomolytic activity. However, intracellular (mainly the nuclear membrane and extracellular obstacles still hamper its efficiency in vitro and in vivo, depending on the route of administration and the type of PEI. Nuclear delivery has been increased by adding nuclear localization signals. To overcome nonspecific interactions with biological fluids, extracellular matrix components and nontarget cells, strategies have been developed to protect polyplexes from these interactions and to increase target specificity and gene expression. When gene delivery into airway epithelial cells of the conducting airways is necessary, aerosolization of complexes seems to be better suited to guarantee higher transgene expression in the airway epithelial cells with lower toxicity than observed with either intratracheal or intravenous administration. Aerosolization, indeed, is useful to target the alveolar epithelium and pulmonary endothelium. Proof-of-principle that PEI-mediated gene delivery has therapeutic application to some genetic and acquired lung disease is presented, using as genetic material either plasmidic DNA or small-interfering RNA, although optimization of formulation and delivery protocols and limitation of toxicity need further studies.Keywords: gene transfer, gene therapy, polyethylenimine, airway epithelial cells, lung, RNA interference

  11. ON BEAUTY AND THE BEAUTIFUL IN AESTHETIC EDUCATION

    Directory of Open Access Journals (Sweden)

    Borce Kostov

    2013-06-01

    Full Text Available We titled our work “On Beauty and the Beautiful in Aesthetic Education” and we analyzed the category beautiful in function of better understanding the issues of aesthetic education.The basic point was the fact that the determination of the term beautiful is being different in both, time aspect and space aspect. Also, the authors involved in this matter have got different understanding on beautiful issue, on its essence, on its role in human development and on the development of the aesthetics and the aesthetic education.Therefore, within our work, there is an attempt to differ the approaches towards the category beautiful, to comment it, to compare it and finally to give our approach.

  12. Small is beautiful

    Energy Technology Data Exchange (ETDEWEB)

    Schumacher, E.F.

    1973-01-01

    The author feels that ''an almost universal idolatry of gigantism'' has caused the urgent crisis of today's society. The book expresses his philosophy of the beauty of thinking in less grandiose terms. He offers some smaller-scale yet highly feasible solutions to many of the problems created by bigness--the environmental crisis, the energy shortage, the dehumanization of industrial workers, the flight from rural areas, and the decay of cities. (MCW)

  13. Politics of Beauty

    Directory of Open Access Journals (Sweden)

    Ken-ichi Sasaki

    2011-01-01

    Full Text Available I look back at the history of modern aesthetics to grasp its current situation and to propose its possibilities for the future. The early modern period, during which aesthetics came into being, was a great historical turning point for civilization. Our contemporary period shares this character, and it is worthwhile for us to consult its history in order to reflect on our civilization. Aesthetics began with Baumgarten’s proposal, which consisted in a triple subject: sensibility, beauty, and art. His idea was accepted because it responded to the fundamental problems of the period. Sensibility was the only form of cognition of value in a re-formed world (Pascal. Art existed in three forms: official, social, and solitary and reflective. The first (San Pietro and Versailles promoted art to the rank of high culture, and it was the third form that presented aesthetics as the philosophy of art. But in the early modern period, aesthetics was first of all the philosophy of beauty because beauty guaranteed the rationality and order of the new world (Shaftesbury, Malebranche. Modern aesthetics, however, was a philosophy of art under the general trends of anthropocentrism. The pursuit of originality led to Duchamp’s Fountain, after which there remains nothing new for art to do. We now confront urgent problems, such as global warming and conflict between different civilizations, etc., which suggest the need for changing the way of managing the world. Under this situation, I think aesthetics holds new and real possibilities for the philosophy of beauty.

  14. Utilizing redox-mediated Bergman cyclization toward the development of dual-action metalloenediyne therapeutics.

    Science.gov (United States)

    Lindahl, Sarah E; Park, Hyunsoo; Pink, Maren; Zaleski, Jeffrey M

    2013-03-13

    Reaction of 2 equiv of 1,2-bis((diphenylphosphino)ethynyl)benzene (dppeb, 1) with Pt(cod)Cl2 followed by treatment with N2H4 yields the reduced Pt(0) metalloenediyne, Pt(dppeb)2, 2. This complex is stable to both air oxidation and metal-mediated Bergman cyclization under ambient conditions due to the nearly idealized tetrahedral geometry. Reaction of 2 with 1 equiv of I2 in the presence of excess 1,4-cyclohexadiene (1,4-CHD) radical trap rapidly and near-quantitatively generates the cis-Bergman-cyclized, diiodo product 3 ((31)P: δ = 41 ppm, J(Pt-P) = 3346 Hz) with concomitant loss of 1 equiv of uncyclized phosphine chelate ((31)P: δ = -33 ppm). In contrast, addition of 2 equiv of I2 in the absence of additional radical trap instantaneously forms a metastable Pt(dppeb)2(2+) intermediate species, 4, that is characterized by δ = 51 ppm in the (31)P NMR (J(Pt-P) = 3171 Hz) and ν(C≡C) = 2169 cm(-1) in the Raman profile, indicating that it is an uncyclized, bis-ligated complex. Over 24 h, 4 undergoes ligand exchange to form a neutral, square planar complex that spontaneously Bergman cyclizes at ambient temperature to give the crystalline product Pt(dppnap-I2)I2 (dppnap-I2 = (1,4-diiodonaphthalene-2,3-diyl)bis(diphenylphosphine)), 5, in 52% isolated yield. Computational analysis of the oxidation reaction proposes two plausible flattened tetrahedral structures for intermediate 4: one where the phosphine core has migrated to a trans-spanning chelate geometry, and a second, higher energy structure (3.3 kcal/mol) with two cis-chelating phosphine ligands (41° dihedral angle) via a restricted alkyne-terminal starting point. While the energies are disparate, the common theme in both structures is the elongated Pt-P bond lengths (>2.4 Å), indicating that nucleophilic ligand substitution by I(-) is on the reaction trajectory to the cyclized product 5. The efficiency of the redox-mediated Bergman cyclization reaction of this stable Pt(0) metalloenediyne prodrug and

  15. Two beautiful new particles

    CERN Multimedia

    Antonella Del Rosso

    2012-01-01

    In beautiful agreement with the Standard Model, two new excited states (see below) of the Λb beauty particle have just been observed by the LHCb Collaboration. Similarly to protons and neutrons, Λb is composed of three quarks. In the Λb’s case, these are up, down and… beauty.   Although discovering new particles is increasingly looking like a routine exercise for the LHC experiments (see previous features), it is far from being an obvious performance, particularly when the mass of the particles is high. Created in the high-energy proton-proton collisions produced by the LHC, these new excited states of the Λb particle have been found to have a mass of, respectively, 5912 MeV/c2 and 5920 MeV/c2. In other words, they are over five times heavier than the proton or the neutron. Physicists only declare a discovery when data significantly show the relevant signal. In order to do that, they often have to analyse large samples of data. To ...

  16. Multiple emulsion-mediated enhancement of the therapeutic effect of tetrandine against silicosis

    Energy Technology Data Exchange (ETDEWEB)

    Chao, D.H.; Ma, J.Y.C.; Malanga, C.J.; Banks, D.E.; Hubbs, A.F.; Rojanasakul, Y.; Castranova, V.; Ma, J.K.H. [West Virginia University, Morgantown, WV (United States). School of Pharmacy

    1996-07-01

    Using a water-in-oil-in-water multiple emulsion system developed for pulmonary drug targeting, the effectiveness of tetrandrine as an antifibrotic agent and the therapeutic advantage of a tetrandrine emulsion over drug in solution for the treatment of silicosis were investigated in rats. Previously it was shown that the action of tetrandrine is attributed to its ability to inhibit the release of reactive oxygen metabolites and inflammatory cytokines by alveolar macrophages, and that targeted delivery of tetrandrine to alveolar macrophages using a multiple emulsion system minimizes drug toxicity, maintains the drug`s pharmacological activity, and enhances tetrandrine distribution in the lungs while reducing systemic drug distribution. This study provides in vivo evidence of emulsion-mediated enhancement of drug action in the lungs against silica-induced lung injury using a rat model. The antifibrotic action of tetrandrine was evaluated by examinations of lung histology, alveolar cell differentials, in vivo drug effect on macrophage respiratory burst, and the measurements of lung weight and collagen content. Tetradrine was shown to inhibit the macrophage-orchestrated inflammatory process in response to silica exposure, preventing infiltration of neutrophils into the alveolar space, it also protected the cells from silica-induced toxicity and stimulation, and restored healthy alveolar macrophage populations in the alveolar region. Intervention of the silica effect with tetrandrine markedly decreased light microscopic lung lesions. These results were supported by inhibition of a silica-induced increase in lung weight and collagen content by tetrandrine. In all experiments the tetrandrine emulsion system was shown to be consistently more efficacious than the solution dosage form in the treatment of silica-induced granulomatous pneumonia, alveolar lipoproteinosis consistent with acute silicosis, and fibrosis. 45 refs., 9 figs., 2 tabs.

  17. Therapeutic impact of systemic AAV-mediated RNA interference in a mouse model of myotonic dystrophy.

    Science.gov (United States)

    Bisset, Darren R; Stepniak-Konieczna, Ewa A; Zavaljevski, Maja; Wei, Jessica; Carter, Gregory T; Weiss, Michael D; Chamberlain, Joel R

    2015-09-01

    RNA interference (RNAi) offers a promising therapeutic approach for dominant genetic disorders that involve gain-of-function mechanisms. One candidate disease for RNAi therapy application is myotonic dystrophy type 1 (DM1), which results from toxicity of a mutant mRNA. DM1 is caused by expansion of a CTG repeat in the 3' UTR of the DMPK gene. The expression of DMPK mRNA containing an expanded CUG repeat (CUG(exp)) leads to defects in RNA biogenesis and turnover. We designed miRNA-based RNAi hairpins to target the CUG(exp) mRNA in the human α-skeletal muscle actin long-repeat (HSA(LR)) mouse model of DM1. RNAi expression cassettes were delivered to HSA(LR) mice using recombinant adeno-associated viral (rAAV) vectors injected intravenously as a route to systemic gene therapy. Vector delivery significantly reduced disease pathology in muscles of the HSA(LR) mice, including a reduction in the CUG(exp) mRNA, a reduction in myotonic discharges, a shift toward adult pre-mRNA splicing patterns, reduced myofiber hypertrophy and a decrease in myonuclear foci containing the CUG(exp) mRNA. Significant reversal of hallmarks of DM1 in the rAAV RNAi-treated HSA(LR) mice indicate that defects characteristic of DM1 can be mitigated with a systemic RNAi approach targeting the nuclei of terminally differentiated myofibers. Efficient rAAV-mediated delivery of RNAi has the potential to provide a long-term therapy for DM1 and other dominant muscular dystrophies.

  18. Ultrasound-mediated oncolytic virus delivery and uptake for increased therapeutic efficacy: state of art

    Directory of Open Access Journals (Sweden)

    Nande R

    2015-11-01

    Full Text Available Rounak Nande,1 Candace M Howard,2 Pier Paolo Claudio,3,4 1Department of Biochemistry and Microbiology, Marshall University School of Medicine, Huntington, WV, 2Department of Radiology, University of Mississippi Medical Center, Jackson, MS, 3Department of BioMolecular Sciences and National Center for Natural Products Research, School of Pharmacy, University of Mississippi, MS, 4Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, MS, USA Abstract: The field of ultrasound (US has changed significantly from medical imaging and diagnosis to treatment strategies. US contrast agents or microbubbles (MB are currently being used as potential carriers for chemodrugs, small molecules, nucleic acids, small interfering ribonucleic acid, proteins, adenoviruses, and oncolytic viruses. Oncolytic viruses can selectively replicate within and destroy a cancer cell, thus making them a powerful therapeutic in treating late-stage or metastatic cancer. These viruses have been shown to have robust activity in clinical trials when injected directly into tumor nodules. However limitations in oncolytic virus’ effectiveness and its delivery approach have warranted exploration of ultrasound-mediated delivery. Gene therapy bearing adenoviruses or oncolytic viruses can be coupled with MBs and injected intravenously. Following application of US energy to the target region, the MBs cavitate, and the resulting shock wave enhances drug, gene, or adenovirus uptake. Though the underlying mechanism is yet to be fully understood, there is evidence to suggest that mechanical pore formation of cellular membranes allows for the temporary uptake of drugs. This delivery method circumvents the limitations due to stimulation of the immune system that prevented intravenous administration of viruses. This review provides insight into this intriguing new frontier on the delivery of oncolytic viruses to tumor sites.Keywords: microbubbles, ultrasound

  19. A school peer mediation program as a context for exploring therapeutic jurisprudence (TJ): Can a peer mediation program inform the law?

    Science.gov (United States)

    McWilliam, Nicky

    2010-01-01

    This paper reports an exploratory study of a school peer mediation program implemented as an alternative way to manage bullying and other destructive conflict. The study explores the effects of the program on the well-being of members of the school community by examining perceptions of students, staff and a sample of parents and former students. Drawing on therapeutic jurisprudence (TJ) the study explores whether the component parts of the program, separately or together, promote intended or unintended therapeutic effects. The preliminary findings of the study emphasise the importance of peer mediation training and suggest that existing scholarship in the area of school conflict resolution and peer mediation, when viewed through a TJ lens, may provide valuable insights into how to optimally configure programs for development and adoption in schools and other community settings. The study highlights the lack of attention paid by the legal system to valuable scholarship in the area of school conflict resolution and peer mediation, which may have implications for the understanding and development of legal processes and the law in general.

  20. Escaping Beauty through moral narratives

    DEFF Research Database (Denmark)

    Sloth, Erik

    2010-01-01

    This study investigate through ethnographic studies the shared cultural meanings expressed about human beauty. How is sense making about the notion of beauty constructed, verballized and negotiated in a group of young females between 24 and 26 years old. Furthermore the study discuss and elaborat...

  1. Sublime Views and Beautiful Explanations

    DEFF Research Database (Denmark)

    Barry, Daved; Meisiek, Stefan; Hatch, Mary Jo

    To create a generative theory that provides beautiful explanations and sublime views requires both a crafts and an art approach to scientific theorizing. The search for generativity leads scholars to perform various theorizing moves between the confines of simple, yet eloquent beauty...

  2. Is better beautiful or is beautiful better? Exploring the relationship between beauty and category structure.

    Science.gov (United States)

    Sanders, Megan; Davis, Tyler; Love, Bradley C

    2013-06-01

    We evaluate two competing accounts of the relationship between beauty and category structure. According to the similarity-based view, beauty arises from category structure such that central items are favored due to their increased fluency. In contrast, the theory-based view holds that people's theories of beauty shape their perceptions of categories. In the present study, subjects learned to categorize abstract paintings into meaningfully labeled categories and rated the paintings' beauty, value, and typicality. Inconsistent with the similarity-based view, beauty ratings were highly correlated across conditions despite differences in fluency and assigned category structure. Consistent with the theory-based view, beautiful paintings were treated as central members for categories expected to contain beautiful paintings (e.g., art museum pieces), but not in others (e.g., student show pieces). These results suggest that the beauty of complex, real-world stimuli is not determined by fluency within category structure but, instead, interacts with people's prior knowledge to structure categories.

  3. BEAUTIFUL, SENSE OF BEAUTY AND ELEMENTS OF BEAUTY IN TURKISH “MÂNİ”

    Directory of Open Access Journals (Sweden)

    Bülent Kahraman Çolakoğlu

    2014-08-01

    Full Text Available This study underlines the “mâni” which represents anonymous folk literature reflecting Turkish cultural life. Turkish nation’s sense of beautiful and beauty, the elements of beauty which belong to beauty/beloved have been studied with reference to Turkish “mâni” in order to protect Turkish cultural treasures and ensure them to be inherited from generation to generation by functionalizing them. In the study, content analysis has been used in the process of data interpretation. 4068 “mâni”s which are in the source tagged with “Demir, Necati (2013, Türk Mânileri, Ankara: Gazi Kitabevi” have been examined and they have been analyzed and assessed in line with the predetermined purpose. With this study, it is consolidated that the Turks have always had advanced sense of beauty; they have always been a nation who has a taste for beauty and taste and sense of aesthetic since the old historical periods. It is observed that the poetic themes of hair, eyebrow, eyelash, eye, beauty spot, cheek-dimple, face, cheek-dewlap, waist, heel, skin, age, speech, smile, smell, jewellery/ornament, deportment, coquetry/manner/affection are used as elements of beauty in Turkish “mâni”.

  4. Engagement with beauty: appreciating natural, artistic, and moral beauty.

    Science.gov (United States)

    Diessner, Rhett; Solom, Rebecca C; Frost, Nellie K; Parsons, Lucas; Davidson, John

    2008-05-01

    The Engagement With Beauty Scale (EBS), designed from the aesthetics of I. Kant (1790/1987), G. W. F. Hegel (ca. 1835/1993), and T. Aquinas (ca. 1260/1947) and the psychological work of J. Haidt (J. Haidt & D. Keltner, 2004), measures engagement with natural, artistic, and moral beauty. In Studies 1 and 2, the authors describe scale construction, exploratory factor analysis, confirmatory factor analysis, internal consistency, and temporal stability. In Studies 1 and 2, the authors also establish concurrent validity with the Appreciation of Beauty and Excellence subscale of the Values in Action Inventory of Strengths (C. Peterson & M. E. P. Seligman, 2004), the Gratitude, Resentment, and Appreciation Test (P. C. Watkins, K. Woodward, T. Stone, & R. L. Kolts, 2003), and the Spiritual Transcendence Scale (R. L. Piedmont, 2004). In Study 3, the authors used the EBS Artistic Beauty subscale to differentiate students engaged in the arts from those who were not.

  5. Therapeutic immunization strategies against cervical cancer : induction of cell-mediated immunity in murine models

    NARCIS (Netherlands)

    Bungener, Laura Barbara

    2004-01-01

    The aim of the study described in this thesis is the development of a therapeutic immunization strategy against cervical cancer and pre-malignant precursor lesions of cervical cancer (CIN lesions). Cervical cancer is caused by high risk human papillomavirus (HPV). Two of the early proteins of high r

  6. Therapeutic Potential of IL-17-Mediated Signaling Pathway in Autoimmune Liver Diseases

    Directory of Open Access Journals (Sweden)

    Haiyan Zhang

    2015-01-01

    Full Text Available Emerging evidence reveals that various cytokines and tissue microenvironments contribute to liver inflammation and autoimmunity, and IL-17 family is one of highlights acknowledged. Although the implication of IL-17 family in most common autoimmune diseases (such as psoriasis, inflammatory bowel disease, and rheumatoid arthritis has been extensively characterized, the role of this critical family in pathophysiology of autoimmune liver diseases (AILD still needs to be clarified. In the review, we look into the intriguing biology of IL-17 family and further dissect on the intricate role of IL-17-mediated pathway in AILD. Considering encouraging data from preclinical and clinical trials, IL-17 targeted therapy has shown promises in several certain autoimmune conditions. However, blocking IL-17-mediated pathway is just beginning, and more fully investigation and reflection are required. Taking together, targeting IL-17-mediated responses may open up new areas of potential clinical treatment for AILD.

  7. Success: Talent, Intelligence or Beauty?

    OpenAIRE

    Gergaud, Olivier; Ginsburgh, Victor

    2010-01-01

    We analyze the Celebrity 100 annual list of the world’s most “powerful celebrities” compiled and published by Forbes Magazine. The lists provide an interesting collection of people, that includes their earnings, and the perception of citizens concerning the attributes that made them become celebrities. We analyze the relationship between their earnings and the perceptions on their intelligence, talent, beauty and other attributes, and show that though beauty plays a role, intelligence and tal...

  8. Evaluation of an Acute RNAi-Mediated Therapeutic for Visual Dysfunction Associated with Traumatic Brain Injury

    Science.gov (United States)

    2013-10-01

    brain injury (TBI) is the leading cause of death in children and young adults globally. Malignant cerebral edema plays a major role in the...pathophysiology which evolves after severe TBI. Added to this is the significant morbidity and mortality from cerebral edema associated with acute stroke...hypoxic ischemic coma, neurological cancers and brain infection. Therapeutic strategies to prevent cerebral edema are limited and if brain swelling

  9. Therapeutic complement inhibition in complement-mediated hemolytic anemias: Past, present and future.

    Science.gov (United States)

    Risitano, Antonio M; Marotta, Serena

    2016-06-01

    The introduction in the clinic of anti-complement agents represented a major achievement which gave to physicians a novel etiologic treatment for different human diseases. Indeed, the first anti-complement agent eculizumab has changed the treatment paradigm of paroxysmal nocturnal hemoglobinuria (PNH), dramatically impacting its severe clinical course. In addition, eculizumab is the first agent approved for atypical Hemolytic Uremic Syndrome (aHUS), a life-threatening inherited thrombotic microangiopathy. Nevertheless, such remarkable milestone in medicine has brought to the fore additional challenges for the scientific community. Indeed, the list of complement-mediated anemias is not limited to PNH and aHUS, and other human diseases can be considered for anti-complement treatment. They include other thrombotic microangiopathies, as well as some antibody-mediated hemolytic anemias. Furthermore, more than ten years of experience with eculizumab led to a better understanding of the individual steps of the complement cascade involved in the pathophysiology of different human diseases. Based on this, new unmet clinical needs are emerging; a number of different strategies are currently under development to improve current anti-complement treatment, trying to address these specific clinical needs. They include: (i) alternative anti-C5 agents, which may improve the heaviness of eculizumab treatment; (ii) broad-spectrum anti-C3 agents, which may improve the efficacy of anti-C5 treatment by intercepting the complement cascade upstream (i.e., preventing C3-mediated extravascular hemolysis in PNH); (iii) targeted inhibitors of selective complement activating pathways, which may prevent early pathogenic events of specific human diseases (e.g., anti-classical pathway for antibody-mediated anemias, or anti-alternative pathway for PNH and aHUS). Here we briefly summarize the status of art of current and future complement inhibition for different complement-mediated anemias

  10. Inhibiting TNF-mediated signaling: a novel therapeutic paradigm for androgen independent prostate cancer

    OpenAIRE

    Srinivasan, Sowmyalakshmi; Kumar, Raj; Koduru, Srinivas; Chandramouli, Aaditya; Damodaran, Chendil

    2010-01-01

    The tumor necrosis factor (TNF) receptor super family comprises of members that induce two distinct signaling cascades, leading to either cell survival or apoptosis. However, in prostate cancer (PCa), TNF-mediated prosurvival signaling is the predominant pathway that leads to cell survival and resistance to therapy. Although inhibition of TNF signaling by pharmacological agents or monoclonal antibodies has gained importance in the field of cancer therapy, toxicity to normal cells has impaired...

  11. Glycoengineering of therapeutic antibodies enhances monocyte/macrophage-mediated phagocytosis and cytotoxicity.

    Science.gov (United States)

    Herter, Sylvia; Birk, Martina C; Klein, Christian; Gerdes, Christian; Umana, Pablo; Bacac, Marina

    2014-03-01

    Therapeutic Abs possess several clinically relevant mechanisms of action including perturbation of tumor cell signaling, activation of complement-dependent cytotoxicity, Ab-dependent cellular cytotoxicity (ADCC), Ab-dependent cellular phagocytosis (ADCP), and induction of adaptive immunity. In view of the important role of phagocytic lineage cells in the mechanism of action of therapeutic Abs, we analyzed FcγR receptor-dependent effector functions of monocytes and macrophages triggered by glycoengineered (GE) Abs (having enhanced FcγRIIIa [CD16a] binding affinity) versus their wild-type (WT) counterparts under different experimental conditions. We first defined the precise FcγR repertoire on classical and nonclassical intermediate monocytes--M1 and M2c macrophage populations. We further show that WT and GE Abs display comparable binding and induce similar effector functions (ADCC and ADCP) in the absence of nonspecific, endogenous IgGs. However, in the presence of these IgGs (i.e., in a situation that more closely mimics physiologic conditions), GE Abs display significantly superior binding and promote stronger monocyte and macrophage activity. These data show that in addition to enhancing CD16a-dependent NK cell cytotoxicity, glycoengineering also enhances monocyte and macrophage phagocytic and cytotoxic activities through enhanced binding to CD16a under conditions that more closely resemble the physiologic setting.

  12. Superparamagnetic Nanoparticles and RNAi-Mediated Gene Silencing: Evolving Class of Cancer Diagnostics and Therapeutics

    Directory of Open Access Journals (Sweden)

    Sanchareeka Dey

    2012-01-01

    Full Text Available The ever increasing death of patients affected by various types of fatal cancers is of concern worldwide. Curative attempts by radiation/chemotherapy and surgery are often a failure in the long run. Moreover, adverse side effects of such treatments burden the patients with painful survival at the last phase of their life. The failure of early diagnosis is one of the root causes of the problem. Intensive research activities are being pursued in reputed laboratories across the globe to find superior diagnostics and therapeutics. Over the last decade, a number of publications have highlighted RNA interference based silencing of cancer-related gene expression as a promising technology to tackle the aforesaid problems. Superparamagnetic iron oxide nanoparticles (SPIONs are reported to be excellent vehicles for short-interfering RNA (siRNA. The SPION-siRNA conjugate is biocompatible, stable, and amenable to specific targeting and can cross the blood brain barrier. The issues related to their synthesis, surface properties, delivery, tracking, imaging in relevance to cancer diagnostic and therapeutic, and so forth demand an extensive review, and we have addressed these aspects in this paper. The future prospects of the technology have also been traced.

  13. Therapeutic Implications of Progesterone Receptor-Mediated Regulation of Cell Cycle in Breast Cancer

    Science.gov (United States)

    2008-10-01

    surprise, we saw a biphasic dose response curve , with lower concentrations of R5020 (100 pM, or 10-10 M) inducing the most robust E2F1 expression at...a classic dose response curve , with maximal activation at the highest concentrations of R5020. However, R5020-mediated induction of E2F1 displays a...biphasic dose response curve ; lower concentrations of R5020 (100 pM, or 10-10 M) induce the most robust E2F1 expression, while higher

  14. HIF-mediated innate immune responses: cell signaling and therapeutic implications

    Directory of Open Access Journals (Sweden)

    Harris AJ

    2014-05-01

    Full Text Available Alison J Harris, AA Roger Thompson, Moira KB Whyte, Sarah R Walmsley Academic Unit of Respiratory Medicine, Department of Infection and Immunity, University of Sheffield, Sheffield, UK Abstract: Leukocytes recruited to infected, damaged, or inflamed tissues during an immune response must adapt to oxygen levels much lower than those in the circulation. Hypoxia inducible factors (HIFs are key mediators of cellular responses to hypoxia and, as in other cell types, HIFs are critical for the upregulation of glycolysis, which enables innate immune cells to produce adenosine triphosphate anaerobically. An increasing body of evidence demonstrates that hypoxia also regulates many other innate immunological functions, including cell migration, apoptosis, phagocytosis of pathogens, antigen presentation and production of cytokines, chemokines, and angiogenic and antimicrobial factors. Many of these functions are mediated by HIFs, which are not only stabilized posttranslationally by hypoxia, but also transcriptionally upregulated by inflammatory signals. Here, we review the role of HIFs in the responses of innate immune cells to hypoxia, both in vitro and in vivo, with a particular focus on myeloid cells, on which the majority of studies have so far been carried out. Keywords: hypoxia, neutrophils, monocytes, macrophages

  15. Soluble mediators of inflammation in HIV and their implications for therapeutics and vaccine development.

    Science.gov (United States)

    Keating, Sheila M; Jacobs, Evan S; Norris, Philip J

    2012-01-01

    From early in the HIV epidemic it was appreciated that many inflammatory markers such as neopterin and TNF-α were elevated in patients with AIDS. With the advent of modern technology able to measure a broad array of cytokines, we now know that from the earliest points of infection HIV induces a cytokine storm. This review will focus on how cytokines are disturbed in HIV infection and will explore potential therapeutic uses of cytokines. These factors can be used directly as therapy during HIV infection, either to suppress viral replication or prevent deleterious immune effects of infection, such as CD4+ T cell depletion. Cytokines also show great promise as adjuvants in the development of HIV vaccines, which would be critical for the eventual control of the epidemic.

  16. Leptin inhibitors from fungal endophytes (LIFEs): Will be novel therapeutic drugs for obesity and its associated immune mediated diseases.

    Science.gov (United States)

    Chandra Mouli, K; Pragathi, D; Naga Jyothi, U; Shanmuga Kumar, V; Himalaya Naik, M; Balananda, P; Suman, B; Seshadri Reddy, V; Vijaya, T

    2016-07-01

    Treatment of obesity and its associated immune mediated diseases is challenging due to impaired function of leptin system. Thus leptin is providing an interesting target for therapeutic intervention. Leptin, an adipose tissue-derived adipokine, displays a variety of immune functions, and regulate both innate and adaptive immune responses. The increased secretion of leptin (hyperleptinemia) and production of proinflammatory cytokines has been implicated in the pathogenesis of obesity-related immune diseases such as diabetes mellitus, hypertension, atherosclerosis, cancer, systemic lupus erythematosus, rheumatoid arthritis, crohn's disease and multiple sclerosis. These disorders are managed through antibiotics and by cytokines replacement. However, the effectiveness of cytokines coupled to the complexity of the cytokine network leads to severe side-effects, which can still occur after careful preclinical evaluation. In addition, synthetic immunotherapeutics carries a degree of risk, is time-consuming and expensive. Hence, the complexity of existing therapy and adverse effects emphasizes the need of an alternative approach for the management of immune dysfunction associated with obesity and its related diseases. For the aforementioned diseases that are related to leptin overabundance, new drugs blocking leptin signaling need to be generated. The research on the discovery of clinically important novel compounds from natural source is expanding due to their safety and no side effect. The fungal endophytes are the microbes that colonize internal tissue of plants without causing negative effects to the host. They produce plethora of substances of potential use to modern medicinal and pharmaceutical industry. The increasing body of evidence associated with application of bioactive metabolites derived from fungal endophytes in diverse disease states merits its use as therapeutic drugs. In particular, the saponins have been extensively proved to modulate the immune system

  17. Characterization of in vitro antibody-dependent cell-mediated cytotoxicity activity of therapeutic antibodies - impact of effector cells.

    Science.gov (United States)

    Chung, Shan; Lin, Yuwen L; Reed, Chae; Ng, Carl; Cheng, Zhijie Jey; Malavasi, Fabio; Yang, Jihong; Quarmby, Valerie; Song, An

    2014-05-01

    Antibody-dependent cell-mediated cytotoxicity (ADCC) is an important mechanism of action implicated in the clinical efficacy of several therapeutic antibodies. In vitro ADCC assays employing effector cells capable of inducing lysis of target cells bound by antibodies are routinely performed to support the research and development of therapeutic antibodies. ADCC assays are commonly performed using peripheral blood mononuclear cells (PBMCs), natural killer (NK) cells or engineered cell lines as effector cells. In this study we evaluated the impact of different effector cell types including primary PBMCs, primary NK cells, engineered NK cell lines, and an engineered reporter cell line, on the in vitro ADCC activity of two glycoforms of a humanized IgG1 antibody. The results of this study show the differential effects on both the efficacy and potency of the antibodies by different effector cells and the finding that both the allotype and the expression level of CD16a affect the potency of effector cells in ADCC assays. Our results also show that engineered NK or reporter cell lines provide reduced variability compared to primary effector cells for in vitro ADCC assays.

  18. Cigarette smoke-mediated perturbations of the immune response: A new therapeutic approach with natural compounds.

    Science.gov (United States)

    Magrone, Thea; Jirillo, Emilio

    2016-09-27

    Cigarette smoke (CS) accounts for the outcome of several pathologies, even including lung cancer, cardiovascular disease and chronic obstructive pulmonary disease (COPD). Under healthy conditions, lung immune system becomes tolerant in response to various external stimuli. CS exposure alters the pulmonary immune equilibrium, thus leading to a condition of hyper activation of the local innate and adaptive immunity. COPD is one of the major complications of chronic CS exposure where a pro-inflammatory profile of the pulmonary and systemic immunity is predominant. In this review, alternative treatments with natural products to mitigate CS-mediated pulmonary inflammation are proposed. In particular, polyphenols, a class of natural compounds largely present in fruits and vegetables, have been shown to act as anti-inflammatory agents. Accordingly, recent experimental and clinical evidences support polyphenol-mediated potential health benefits in smokers. For instance, pomegranate juice is able to attenuate the damage provoked by CS on cultured human alveolar macrophages. In addition, maqui beery extract has been proven to normalize H2O2 and interleukin-6 levels in exhaled breath condensate in healthy smokers. However, some limitations of alternative treatments are represented by a better knowledge of the mechanism(s) of action exerted by polyphenols and by the lack of animal models of COPD. In any case, the potential targets of polyphenols in the course of COPD will be outlined with special reference to the activation of T regulatory cells as well as to the inhibition of the polymorphonuclear cell and monocyte respiratory burst and of the NF-kB pathway, respectively.

  19. Physiological and Therapeutic Vascular Remodeling Mediated by Hypoxia-Inducible Factor 1

    Science.gov (United States)

    Sarkar, Kakali; Semenza, Gregg L.

    Angiogenesis along with arteriogenesis and vasculogenesis is a fundamental process in ischemic repair in adult animals including humans. Hypoxia-inducible factor 1 (HIF-1) plays a central role in mediating adaptive responses to hypoxia/ischemia by expressing angiogenic cytokines/growth factors and their cognate receptors. Angiogenic growth factors are the homing signal for circulating angiogenic cells (CACs), which are mobilized to peripheral blood from bone marrow, recruited to target tissues, and promote vascularization. Impairment of HIF-1-mediated gene transcription contributes to the impaired vascular responses in peripheral vascular disease that are associated with aging and diabetes. Promoting neovascularization in ischemic tissues is a promising strategy for the treatment of peripheral vascular disease when surgical or catheter-based revascularization is not possible. Intramuscular injection of an adenovirus encoding a constitutively active form of HIF-1α (AdCA5), into the ischemic limb of diabetic mice increases the recovery of limb perfusion and function, rescues the diabetes-associated impairment of CACs, and increases vascularization. Administration of AdCA5 overcomes the effect of aging on recovery of blood flow in middle-aged mice following femoral artery ligation in a mouse model of age-dependent critical limb ischemia. Intramuscular injection of AdCA5 along with intravenous injection of bone-marrow-derived angiogenic cells cultured in the presence of prolyl-4-hydroxylase inhibitor dimethyloxalylglycine, increases blood flow and limb salvage in old mice following femoral artery ligation. HIF-1α gene therapy increases homing of bone-marrow-derived cells, whereas induction of HIF-1 in these cells increases their retention in the ischemic tissue by increasing their adhesion to endothelium leading to synergistic effects of combined therapy on improving blood flow.

  20. Peptide-Mediated Delivery of Chemical Probes and Therapeutics to Mitochondria.

    Science.gov (United States)

    Jean, Sae Rin; Ahmed, Marya; Lei, Eric K; Wisnovsky, Simon P; Kelley, Shana O

    2016-09-20

    Mitochondria are organelles with critical roles in key processes within eukaryotic cells, and their dysfunction is linked with numerous diseases including neurodegenerative disorders and cancer. Pharmacological manipulation of mitochondrial function is therefore important both for basic science research and eventually, clinical medicine. However, in comparison to other organelles, mitochondria are difficult to access due to their hydrophobic and dense double membrane system as well as their negative membrane potential. To tackle the challenge of targeting these important subcellular compartments, significant effort has been put forward to develop mitochondria-targeted systems capable of transporting bioactive cargo into the mitochondrial interior. Systems now exist that utilize small molecule, peptide, liposome, and nanoparticle-based transport. The vectors available vary in size and structure and can facilitate transport of a variety of compounds for mitochondrial delivery. Notably, peptide-based delivery scaffolds offer attractive features such as ease of synthesis, tunability, biocompatibility, and high uptake both in cellulo and in vivo. Owing to their simple and modular synthesis, these peptides are highly adaptable for delivering chemically diverse cargo. Key design features of mitochondria-targeted peptides include cationic charge, which allows them to harness the negative membrane potential of mitochondria, and lipophilicity, which permits favorable interaction with hydrophobic membranes of mitochondria. These peptides have been covalently tethered to target therapeutic agents, including anticancer drugs, to enhance their drug properties, and to provide probes for mitochondrial biology. Interestingly, mitochondria-targeted DNA damaging agents demonstrate high potency and the ability to evade resistance mechanisms and off-target effects. Moreover, a combination of mitochondria-targeted DNA damaging agents was applied to an siRNA screen for the elucidation of

  1. Sleeping Beauties in Meme Diffusion

    CERN Document Server

    Zhang, Leihan; Xu, Ke

    2016-01-01

    A sleeping beauty in diffusion indicates that the information, can be ideas or innovations, will experience a hibernation before a sudden spike of popularity and it is widely found in citation history of scientific publications. However, in this study, we demonstrate that the sleeping beauty is an universal phenomenon in information diffusion and even more inspiring, there exist two consecutive sleeping beauties in the entire lifetime of propagation, suggesting that the information, including trending topics, search queries or Wikipedia views, which we call memes, will go unnoticed for a period and suddenly attracts some attention, and then it falls asleep again and later wakes up with another unexpected popularity peak. Further explorations on this phenomenon show that intervals between two wake ups follow an exponential distribution and the second awakening stage generally reaches its peak at a higher velocity and will bring a wider dissemination. Taking these findings into consideration, the upgraded Bass ...

  2. The golden beauty: brain response to classical and renaissance sculptures.

    Science.gov (United States)

    Di Dio, Cinzia; Macaluso, Emiliano; Rizzolatti, Giacomo

    2007-01-01

    Is there an objective, biological basis for the experience of beauty in art? Or is aesthetic experience entirely subjective? Using fMRI technique, we addressed this question by presenting viewers, naïve to art criticism, with images of masterpieces of Classical and Renaissance sculpture. Employing proportion as the independent variable, we produced two sets of stimuli: one composed of images of original sculptures; the other of a modified version of the same images. The stimuli were presented in three conditions: observation, aesthetic judgment, and proportion judgment. In the observation condition, the viewers were required to observe the images with the same mind-set as if they were in a museum. In the other two conditions they were required to give an aesthetic or proportion judgment on the same images. Two types of analyses were carried out: one which contrasted brain response to the canonical and the modified sculptures, and one which contrasted beautiful vs. ugly sculptures as judged by each volunteer. The most striking result was that the observation of original sculptures, relative to the modified ones, produced activation of the right insula as well as of some lateral and medial cortical areas (lateral occipital gyrus, precuneus and prefrontal areas). The activation of the insula was particularly strong during the observation condition. Most interestingly, when volunteers were required to give an overt aesthetic judgment, the images judged as beautiful selectively activated the right amygdala, relative to those judged as ugly. We conclude that, in observers naïve to art criticism, the sense of beauty is mediated by two non-mutually exclusive processes: one based on a joint activation of sets of cortical neurons, triggered by parameters intrinsic to the stimuli, and the insula (objective beauty); the other based on the activation of the amygdala, driven by one's own emotional experiences (subjective beauty).

  3. Skin temperature increase mediated by wearable, long duration, low-intensity therapeutic ultrasound

    Science.gov (United States)

    Langer, Matthew D.; Huang, Wenyi; Ghanem, Angi; Guo, Yuan; Lewis, George K.

    2017-03-01

    One of the safety concerns with the delivery of therapeutic ultrasound is overheating of the transducer-skin interface due to poor or improper coupling. The objective of this research was to define a model that could be used to calculate the heating in the skin as a result of a novel, wearable long-duration ultrasound device. This model was used to determine that the maximum heating in the skin remained below the minimum threshold necessary to cause thermal injury over multiple hours of use. In addition to this model data, a human clinical study used wire thermocouples on the skin surface to measure heating characteristics during treatment with the sustained ultrasound system. Parametric analysis of the model determined that the maximum temperature increase is at the surface of the skin ranged from 40-41.8° C when perfusion was taken into account. The clinical data agreed well with the model predictions. The average steady state temperature observed across all 44 subjects was 40°C. The maximum temperature observed was less than 44° C, which is clinically safe for over 5 hours of human skin contact. The resultant clinical temperature data paired well with the model data suggesting the model can be used for future transducer and ultrasound system design simulation. As a result, the device was validated for thermal safety for typical users and use conditions.

  4. Therapeutic effect of curcumin on experimental colitis mediated by inhibiting CD8+CD11c+ cells

    Science.gov (United States)

    Zhao, Hai-Mei; Han, Fei; Xu, Rong; Huang, Xiao-Ying; Cheng, Shao-Min; Huang, Min-Fang; Yue, Hai-Yang; Wang, Xin; Zou, Yong; Xu, Han-Lin; Liu, Duan-Yong

    2017-01-01

    AIM To verify whether curcumin (Cur) can treat inflammatory bowel disease by regulating CD8+CD11c+ cells. METHODS We evaluated the suppressive effect of Cur on CD8+CD11c+ cells in spleen and Peyer’s patches (PPs) in colitis induced by trinitrobenzene sulfonic acid. Mice with colitis were treated by 200 mg/kg Cur for 7 d. On day 8, the therapeutic effect of Cur was evaluated by visual assessment and histological examination, while co-stimulatory molecules of CD8+CD11c+ cells in the spleen and PPs were measured by flow cytometry. The levels of interleukin (IL)-10, interferon (IFN)-γ and transforming growth factor (TGF)-β1 in spleen and colonic mucosa were determined by ELISA. RESULTS The disease activity index, colon weight, weight index of colon and histological score of experimental colitis were obviously decreased after Cur treatment, while the body weight and colon length recovered. After treatment with Cur, CD8+CD11c+ cells were decreased in the spleen and PPs, and the expression of major histocompatibility complex II, CD205, CD40, CD40L and intercellular adhesion molecule-1 was inhibited. IL-10, IFN-γ and TGF-β1 levels were increased compared with those in mice with untreated colitis. CONCLUSION Cur can effectively treat experimental colitis, which is realized by inhibiting CD8+CD11c+ cells. PMID:28348486

  5. Fucose decorated solid-lipid nanocarriers mediate efficient delivery of methotrexate in breast cancer therapeutics.

    Science.gov (United States)

    Garg, Neeraj K; Singh, Bhupinder; Jain, Ashay; Nirbhavane, Pradip; Sharma, Rajeev; Tyagi, Rajeev K; Kushwah, Varun; Jain, Sanyog; Katare, Om Prakash

    2016-10-01

    The present study is designed to engineer fucose anchored methotrexate loaded solid lipid nanoparticles (SLNs) to target breast cancer. The developed nano-carriers were characterized with respect to particle size, PDI, zeta potential, drug loading and entrapment, in-vitro release etc. The characterized formulations were used to comparatively assess cellular uptake, cell-viability, apoptosis, lysosomal membrane permeability, bioavailability, biodistribution, changes in tumor volume and animal survival. The ex-vivo results showed greater cellular uptake and better cytotoxicity at lower IC50 of methotrexate in breast cancer cells. Further, we observed increased programmed cell death (apoptosis) with altered lysosomal membrane permeability and better rate of degradation of lysosomal membrane in-vitro. On the other hand, in-vivo evaluation showed maximum bioavailability and tumor targeting efficiency with minimum secondary drug distribution in various organs with formulated and anchored nano-carrier when compared with free drug. Moreover, sizeable reduction in tumor burden was estimated with fucose decorated SLNs as compared to that seen with free MTX and SLNs-MTX. Fucose decorated SLNs showed promising results to develop therapeutic interventions for breast cancer, and paved a way to explore this promising and novel nano-carrier which enables to address breast cancer.

  6. NYINGCHI,THE NATURAL BEAUTY,AND THE BEAUTY OF NATURE

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    "This beautiful place",Nyingchi,refers to the beauty of mountain ranges,water,valleys,lakes,and even glaciers.No matter how it is defined or named in accordance with tradition, it will never be excessive to credit this place with the description of beautiful;such beauty is barely defined by words.

  7. The Staunch Beauty of Flowers

    Institute of Scientific and Technical Information of China (English)

    1998-01-01

    MANY women like to collect dried flowers. Unable to bear the sight of beautiful blossoms withering, they press them between the leaves of books. As time passes, the original fresh flowers turn into thin pale-colored specimens, but a careful viewer will notice that they have taken on a new grace—just like Ren Jie herself; though no longer young, she has managed to create beauty out of her later life. Ren Jie’s love of flowers dates back to her childhood, when she started to collect flower specimens. As she grew up, she learned how to paint; later, she

  8. Beauty and brains don't mix?

    OpenAIRE

    Fallesen, Krista Bjerknæs; Schultz, Astrid Andrea; Nielsen, Christine Strube; Hansen, Sandra Springborg

    2014-01-01

    This project revolves around beautiful people. There do not exist a recipe for having a beautiful appearance, but we are from childhood as individuals 'coded' to recognize what is beautiful. This project is based on the fact that beautiful people are assigned values that they do not necessarily possess. These values will be described through Pierre Bourdieu's theory about capital and habitus. Some values will be examined especially in relation to one's job situation. Today's labor market will...

  9. β-arrestins: regulatory role and therapeutic potential in opioid and cannabinoid receptor-mediated analgesia.

    Science.gov (United States)

    Raehal, Kirsten M; Bohn, Laura M

    2014-01-01

    Pain is a complex disorder with neurochemical and psychological components contributing to the severity, the persistence, and the difficulty in adequately treating the condition. Opioid and cannabinoids are two classes of analgesics that have been used to treat pain for centuries and are arguably the oldest of "pharmacological" interventions used by man. Unfortunately, they also produce several adverse side effects that can complicate pain management. Opioids and cannabinoids act at G protein-coupled receptors (GPCRs), and much of their effects are mediated by the mu-opioid receptor (MOR) and cannabinoid CB1 receptor (CB1R), respectively. These receptors couple to intracellular second messengers and regulatory proteins to impart their biological effects. In this chapter, we review the role of the intracellular regulatory proteins, β-arrestins, in modulating MOR and CB1R and how they influence the analgesic and side-effect profiles of opioid and cannabinoid drugs in vivo. This review of the literature suggests that the development of opioid and cannabinoid agonists that bias MOR and CB1R toward G protein signaling cascades and away from β-arrestin interactions may provide a novel mechanism by which to produce analgesia with less severe adverse effects.

  10. Plant-Mediated Synthesis of Silver Nanoparticles: Their Characteristic Properties and Therapeutic Applications

    Science.gov (United States)

    Chung, Ill-Min; Park, Inmyoung; Seung-Hyun, Kim; Thiruvengadam, Muthu; Rajakumar, Govindasamy

    2016-01-01

    Interest in "green nanotechnology" in nanoparticle biosynthesis is growing among researchers. Nanotechnologies, due to their physicochemical and biological properties, have applications in diverse fields, including drug delivery, sensors, optoelectronics, and magnetic devices. This review focuses on the green synthesis of silver nanoparticles (AgNPs) using plant sources. Green synthesis of nanoparticles is an eco-friendly approach, which should be further explored for the potential of different plants to synthesize nanoparticles. The sizes of AgNPs are in the range of 1 to 100 nm. Characterization of synthesized nanoparticles is accomplished through UV spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, transmission electron microscopy, and scanning electron microscopy. AgNPs have great potential to act as antimicrobial agents. The green synthesis of AgNPs can be efficiently applied for future engineering and medical concerns. Different types of cancers can be treated and/or controlled by phytonanotechnology. The present review provides a comprehensive survey of plant-mediated synthesis of AgNPs with specific focus on their applications, e.g., antimicrobial, antioxidant, and anticancer activities.

  11. Performance of Pain, Performance of Beauty

    Science.gov (United States)

    Thompson, James

    2006-01-01

    "Performance of pain, performance of beauty" explores performance projects in war zones using Elaine Scarry's definitions of "pain" and "beauty" as a starting point. The way in which pain constricts the body and the experience that beauty can take a person beyond the body become a contested framework for considering two examples of performance.…

  12. Significance and therapeutic implications of endothelial progenitor cells in angiogenic-mediated tumour metastasis.

    Science.gov (United States)

    Flamini, Valentina; Jiang, Wen G; Lane, Jane; Cui, Yu-Xin

    2016-04-01

    Cancer conveys profound social and economic consequences throughout the world. Metastasis is responsible for approximately 90% of cancer-associated mortality and, when it occurs, cancer becomes almost incurable. During metastatic dissemination, cancer cells pass through a series of complex steps including the establishment of tumour-associated angiogenesis. The human endothelial progenitor cells (hEPCs) are a cell population derived from the bone marrow which are required for endothelial tubulogenesis and neovascularization. They also express abundant inflammatory cytokines and paracrine angiogenic factors. Clinically hEPCs are highly correlated with relapse, disease progression, metastasis and treatment response in malignancies such as breast cancer, ovarian cancer and non-small-cell lung carcinoma. It has become evident that the hEPCs are involved in the angiogenesis-required progression and metastasis of tumours. However, it is not clear in what way the signalling pathways, controlling the normal cellular function of human BM-derived EPCs, are hijacked by aggressive tumour cells to facilitate tumour metastasis. In addition, the actual roles of hEPCs in tumour angiogenesis-mediated metastasis are not well characterised. In this paper we reviewed the clinical relevance of the hEPCs with cancer diagnosis, progression and prognosis. We further summarised the effects of tumour microenvironment on the hEPCs and underlying mechanisms. We also hypothesized the roles of altered hEPCs in tumour angiogenesis and metastasis. We hope this review may enhance our understanding of the interaction between hEPCs and tumour cells thus aiding the development of cellular-targeted anti-tumour therapies.

  13. Targeting hypoxia-mediated mucin 2 production as a therapeutic strategy for mucinous tumors.

    Science.gov (United States)

    Dilly, Ashok K; Lee, Yong J; Zeh, Herbert J; Guo, Zong Sheng; Bartlett, David L; Choudry, Haroon A

    2016-03-01

    Excessive accumulation of mucin 2 (MUC2; a gel-forming secreted mucin) protein in the peritoneal cavity is the major cause of morbidity and mortality in pseudomyxoma peritonei (PMP). Hypoxia (hypoxia-inducible factor-1α; HIF-1α) has been shown to regulate the expression of similar mucins (eg, MUC5AC). We hypothesized that hypoxia (HIF-1α) drives MUC2 expression in PMP and is therefore a novel target to reduce mucinous tumor growth. The regulation of MUC2 by 2% hypoxia (HIF-1α) was evaluated in MUC2-secreting LS174T cells. The effect of BAY 87-2243, an inhibitor of HIF-1α, on MUC2 expression and mucinous tumor growth was evaluated in LS174T cells, PMP explant tissue, and in a unique intraperitoneal murine xenograft model of PMP. In vitro exposure of LS174T cells to hypoxia increased MUC2 messenger RNA (mRNA) and protein expression and increased HIF-1α binding to the MUC2 promoter. Hypoxia-mediated MUC2 protein overexpression was downregulated by transfected HIF-1α small interfering RNA (siRNA) compared with scrambled siRNA in LS174T cells. BAY 87-2243 inhibited hypoxia-induced MUC2 mRNA and protein expression in LS174T cells and PMP explant tissue. In a murine xenograft model of PMP, chronic oral therapy with BAY 87-2243 inhibited mucinous tumor growth and MUC2, HIF-1α expression in the tumor tissue. Our data suggest that hypoxia (HIF-1α) induces MUC2 promoter activity to increase MUC2 expression. HIF-1α inhibition decreases MUC2 production and mucinous tumor growth, providing a preclinical rationale for the use of HIF-1α inhibitors to treat patients with PMP.

  14. Sex, beauty and the orbitofrontal cortex.

    Science.gov (United States)

    Ishai, Alumit

    2007-02-01

    Face perception is mediated by a distributed neural system in the human brain. Attention, memory and emotion modulate the neural activation evoked by faces, however the effects of gender and sexual orientation are currently unknown. To test whether subjects would respond more to their sexually-preferred faces, we scanned 40 hetero- and homosexual men and women whilst they assessed facial attractiveness. Behaviorally, regardless of their gender and sexual orientation, all subjects similarly rated the attractiveness of both male and female faces. Consistent with our hypothesis, a three-way interaction between stimulus gender, beauty and the sexual preference of the subject was found in the medial orbitofrontal cortex (OFC). In heterosexual women and homosexual men, attractive male faces elicited stronger activation than attractive female faces, whereas in heterosexual men and homosexual women, attractive female faces evoked stronger activation than attractive male faces. These findings suggest that the OFC represents the value of salient sexually-relevant faces, irrespective of their reproductive fitness.

  15. YONGJIA,MY BEAUTIFUL HOMETOWN

    Institute of Scientific and Technical Information of China (English)

    袁淑婷; 陈予冰

    2004-01-01

    My hometown Yongjia is a very beautiful place.It is situated in the southeast of Zhejiang Province,on the north bank of the lower Oujiang River.It consists of 14 towns and 28 townships and boasts a total area of 2,698.2 square kilometers.

  16. Beauty in a multicultural world.

    Science.gov (United States)

    Weeks, David M; Thomas, J Regan

    2014-08-01

    The increased demand for facial cosmetic surgery has come from a more diverse, informed, and selective patient population from all walks of life. Virtually no two patients have the same background or cosmetic objectives. However, the classic tenets of beauty including phi, symmetry, averageness, youthfulness, and sexual dimorphism can be applied to persons of all ethnicities to assist in objectifying the abstract concept.

  17. Computers, pattern, chaos and beauty

    CERN Document Server

    Pickover, Clifford A

    1980-01-01

    Combining fractal theory with computer art, this book introduces a creative use of computers. It describes graphic methods for detecting patterns in complicated data and illustrates simple techniques for visualizing chaotic behavior. ""Beautiful."" - Martin Gardner, Scientific American. Over 275 illustrations, 29 in color.

  18. Dextrose-mediated aggregation of therapeutic monoclonal antibodies in human plasma: Implication of isoelectric precipitation of complement proteins.

    Science.gov (United States)

    Luo, Shen; Zhang, Baolin

    2015-01-01

    Many therapeutic monoclonal antibodies (mAbs) are clinically administered through intravenous infusion after mixing with a diluent, e.g., saline, 5% dextrose. Such a clinical setting increases the likelihood of interactions among mAb molecules, diluent, and plasma components, which may adversely affect product safety and efficacy. Avastin® (bevacizumab) and Herceptin® (trastuzumab), but not Remicade® (infliximab), were shown to undergo rapid aggregation upon dilution into 5% dextrose when mixed with human plasma in vitro; however, the biochemical pathways leading to the aggregation were not clearly defined. Here, we show that dextrose-mediated aggregation of Avastin or Herceptin in plasma involves isoelectric precipitation of complement proteins. Using mass spectrometry, we found that dextrose-induced insoluble aggregates were composed of mAb itself and multiple abundant plasma proteins, namely complement proteins C3, C4, factor H, fibronectin, and apolipoprotein. These plasma proteins, which are characterized by an isoelectronic point of 5.5-6.7, lost solubility at the resulting pH in the mixture with formulated Avastin (pH 6.2) and Herceptin (pH 6.0). Notably, switching formulation buffers for Avastin (pH 6.2) and Remicade (pH 7.2) reversed their aggregation profiles. Avastin formed little, if any, insoluble aggregates in dextrose-plasma upon raising the buffer pH to 7.2 or above. Furthermore, dextrose induced pH-dependent precipitation of plasma proteins, with massive insoluble aggregates being detected at pH 6.5-6.8. These data show that isoelectric precipitation of complement proteins is a prerequisite of dextrose-induced aggregation of mAb in human plasma. This finding highlights the importance of assessing the compatibility of a therapeutic mAb with diluent and human plasma during product development.

  19. Exploiting MEK inhibitor-mediated activation of ERα for therapeutic intervention in ER-positive ovarian carcinoma.

    Directory of Open Access Journals (Sweden)

    June Y Hou

    Full Text Available While the clinical benefit of MEK inhibitor (MEKi-based therapy is well established in Raf mutant malignancies, its utility as a suppressor of hyperactive MAPK signaling in the absence of mutated Raf or Ras, is an area of ongoing research. MAPK activation is associated with loss of ERα expression and hormonal resistance in numerous malignancies. Herein, we demonstrate that MEKi induces a feedback response that results in ERα overexpression, phosphorylation and transcriptional activation of ER-regulated genes. Mechanistically, MEKi-mediated ERα overexpression is largely independent of erbB2 and AKT feedback activation, but is ERK-dependent. We subsequently exploit this phenomenon therapeutically by combining the ER-antagonist, fulvestrant with MEKi. This results in synergistic suppression of tumor growth, in vitro and potentiation of single agent activity in vivo in nude mice bearing xenografts. Thus, we demonstrate that exploiting adaptive feedback after MEKi can be used to sensitize ERα-positive tumors to hormonal therapy, and propose that this strategy may have broader clinical utility in ERα-positive ovarian carcinoma.

  20. Therapeutic AAV9-mediated suppression of mutant SOD1 slows disease progression and extends survival in models of inherited ALS.

    Science.gov (United States)

    Foust, Kevin D; Salazar, Desirée L; Likhite, Shibi; Ferraiuolo, Laura; Ditsworth, Dara; Ilieva, Hristelina; Meyer, Kathrin; Schmelzer, Leah; Braun, Lyndsey; Cleveland, Don W; Kaspar, Brian K

    2013-12-01

    Mutations in superoxide dismutase 1 (SOD1) are linked to familial amyotrophic lateral sclerosis (ALS) resulting in progressive motor neuron death through one or more acquired toxicities. Involvement of wild-type SOD1 has been linked to sporadic ALS, as misfolded SOD1 has been reported in affected tissues of sporadic patients and toxicity of astrocytes derived from sporadic ALS patients to motor neurons has been reported to be reduced by lowering the synthesis of SOD1. We now report slowed disease onset and progression in two mouse models following therapeutic delivery using a single peripheral injection of an adeno-associated virus serotype 9 (AAV9) encoding an shRNA to reduce the synthesis of ALS-causing human SOD1 mutants. Delivery to young mice that develop aggressive, fatal paralysis extended survival by delaying both disease onset and slowing progression. In a later-onset model, AAV9 delivery after onset markedly slowed disease progression and significantly extended survival. Moreover, AAV9 delivered intrathecally to nonhuman primates is demonstrated to yield robust SOD1 suppression in motor neurons and glia throughout the spinal cord and therefore, setting the stage for AAV9-mediated therapy in human clinical trials.

  1. The beauty and the beast inside: the american beauty--does cosmetic surgery help?

    Science.gov (United States)

    Lijtmaer, Ruth

    2010-01-01

    American society's feminine ideal has consistently emphasized youth as beauty and getting old as ugly. Feeling unattractive produces several intrapsychic conflicts leading to depression and anxiety. Summary of the literature on beauty and aging, beauty and culture, and theories of physical beauty will be presented. With a clinical example of a female patient, the writer investigates the conscious and unconscious fantasies, conflicts, and sense of self inside and outside that impelled a physically beautiful female patient to bring her own body closer to her perception of idealized beauty with the aid of plastic surgery.

  2. Facial beauty and fractal geometry

    OpenAIRE

    Schmidhuber, Juergen

    1998-01-01

    What is it that makes a face beautiful? Average faces obtained by photographic (Galton 1878) or digital (Langlois & Roggman 1990) blending are judged attractive but not optimally attractive (Alley & Cunningham 1991) --- digital exaggerations of deviations from average face blends can lead to higher attractiveness ratings (Perrett, May, & Yoshikawa 1994). My novel approach to face design does not involve blending at all. Instead, the image of a female face with high ratings is composed from a ...

  3. Is moral beauty different from facial beauty? Evidence from an fMRI study.

    Science.gov (United States)

    Wang, Tingting; Mo, Lei; Mo, Ce; Tan, Li Hai; Cant, Jonathan S; Zhong, Luojin; Cupchik, Gerald

    2015-06-01

    Is moral beauty different from facial beauty? Two functional magnetic resonance imaging experiments were performed to answer this question. Experiment 1 investigated the network of moral aesthetic judgments and facial aesthetic judgments. Participants performed aesthetic judgments and gender judgments on both faces and scenes containing moral acts. The conjunction analysis of the contrasts 'facial aesthetic judgment > facial gender judgment' and 'scene moral aesthetic judgment > scene gender judgment' identified the common involvement of the orbitofrontal cortex (OFC), inferior temporal gyrus and medial superior frontal gyrus, suggesting that both types of aesthetic judgments are based on the orchestration of perceptual, emotional and cognitive components. Experiment 2 examined the network of facial beauty and moral beauty during implicit perception. Participants performed a non-aesthetic judgment task on both faces (beautiful vs common) and scenes (containing morally beautiful vs neutral information). We observed that facial beauty (beautiful faces > common faces) involved both the cortical reward region OFC and the subcortical reward region putamen, whereas moral beauty (moral beauty scenes > moral neutral scenes) only involved the OFC. Moreover, compared with facial beauty, moral beauty spanned a larger-scale cortical network, indicating more advanced and complex cerebral representations characterizing moral beauty.

  4. Is moral beauty different from facial beauty? Evidence from an fMRI study

    Science.gov (United States)

    Wang, Tingting; Mo, Ce; Tan, Li Hai; Cant, Jonathan S.; Zhong, Luojin; Cupchik, Gerald

    2015-01-01

    Is moral beauty different from facial beauty? Two functional magnetic resonance imaging experiments were performed to answer this question. Experiment 1 investigated the network of moral aesthetic judgments and facial aesthetic judgments. Participants performed aesthetic judgments and gender judgments on both faces and scenes containing moral acts. The conjunction analysis of the contrasts ‘facial aesthetic judgment > facial gender judgment’ and ‘scene moral aesthetic judgment > scene gender judgment’ identified the common involvement of the orbitofrontal cortex (OFC), inferior temporal gyrus and medial superior frontal gyrus, suggesting that both types of aesthetic judgments are based on the orchestration of perceptual, emotional and cognitive components. Experiment 2 examined the network of facial beauty and moral beauty during implicit perception. Participants performed a non-aesthetic judgment task on both faces (beautiful vs common) and scenes (containing morally beautiful vs neutral information). We observed that facial beauty (beautiful faces > common faces) involved both the cortical reward region OFC and the subcortical reward region putamen, whereas moral beauty (moral beauty scenes > moral neutral scenes) only involved the OFC. Moreover, compared with facial beauty, moral beauty spanned a larger-scale cortical network, indicating more advanced and complex cerebral representations characterizing moral beauty. PMID:25298010

  5. Performing Beauty in Participatory Art and Culture

    DEFF Research Database (Denmark)

    Heinrich, Falk

    This book investigates the notion of beauty in participatory art, an interdisciplinary form that necessitates the audience’s agential participation and that is often seen in interactive art and technology-driven media installations. After considering established theories of beauty, for example......, Plato, Alison, Hume, Kant, Gadamer and Santayana through to McMahon and Sartwell, Heinrich argues that the experience of beauty in participatory art demands a revised notion of beauty; a conception that accounts for the performative and ludic turn within various art forms and which is, in a broader...... sense, a notion of beauty suited to a participatory and technology-saturated culture. Through case studies of participatory art, he provides an art-theoretical approach to the concept of performative beauty; an approach that is then applied to the wider context of media and design artefacts....

  6. Mate choice decisions: the role of facial beauty.

    Science.gov (United States)

    Johnston, Victor S

    2006-01-01

    For most people, facial beauty appears to play a prominent role in choosing a mate. Evidence from research on facial attractiveness indicates that physical beauty is a sexually selected trait mediated, in part, by pubertal facial hormone markers that signal important biological information about the displayer. Such signals would be ineffective if they did not elicit appropriate cognitive and/or emotional responses in members of the opposite sex. In this article, I argue that the effectiveness of these hormonal displays varies with perceivers' brains, which have been organized by the degree of steroid hormone exposure in the uterus, and activated by varying levels of circulating steroids following puberty. I further propose that the methodology used for examining mate choice decisions has general applicability for determining how cognitive and emotional evaluations enter into decision processes.

  7. Lipid raft-mediated Fas/CD95 apoptotic signaling in leukemic cells and normal leukocytes and therapeutic implications.

    Science.gov (United States)

    Gajate, Consuelo; Mollinedo, Faustino

    2015-11-01

    Plasma membrane is now recognized to contain tightly packed cholesterol/sphingolipid-rich domains, known as lipid or membrane rafts, which are more ordered than the surrounding lipid bilayer. Lipid rafts are crucial for the compartmentalization of signaling processes in the membrane, mostly involved in cell survival and immune response. However, in the last 15 years, a large body of evidence has also identified raft platforms as scaffolds for the recruitment and clustering of death receptor Fas/CD95 and downstream signaling molecules, leading to the concept of death-promoting lipid rafts. This raft-Fas/CD95 coclustering was first described at the early 2000s as the underlying mechanism for the proapoptotic action of the alkylphospholipid analog edelfosine in leukemic cells, hence facilitating protein-protein interactions and conveying apoptotic signals independently of Fas/CD95 ligand. Edelfosine induces apoptosis in hematologic cancer cells and activated T-lymphocytes. Fas/CD95 raft coclustering is also promoted by Fas/CD95 ligand, agonistic Fas/CD95 antibodies, and additional antitumor drugs. Thus, death receptor recruitment in rafts is a physiologic process leading to cell demise that can be pharmacologically modulated. This redistribution and local accumulation of apoptotic molecules in membrane rafts, which are usually accompanied by displacement of survival signaling molecules, highlight how alterations in the apoptosis/survival signaling balance in specialized membrane regions modulate cell fate. Membrane rafts might also modulate apoptotic and nonapoptotic death receptor signaling. Here, we discuss the role of lipid rafts in Fas/CD95-mediated apoptotic cell signaling in hematologic cancer cells and normal leukocytes, with a special emphasis on their involvement as putative therapeutic targets in cancer and autoimmune diseases.

  8. Flow-mediated vasodilation as a predictor of therapeutic response to midodrine hydrochloride in children with postural orthostatic tachycardia syndrome.

    Science.gov (United States)

    Liao, Ying; Yang, Jinyan; Zhang, Fengwen; Chen, Stella; Liu, Xueqin; Zhang, Qingyou; Ai, Yi; Wang, Yuli; Tang, Chaoshu; Du, Junbao; Jin, Hongfang

    2013-09-15

    This study was designed to explore the value of flow-mediated vasodilation (FMD) as a predictor of therapeutic response to midodrine hydrochloride (MD) in children with postural orthostatic tachycardia syndrome (POTS). One hundred and eight children diagnosed with POTS and 20 healthy control children were enrolled. All children with POTS received MD and were followed up for 3 months. FMD of brachial artery for each participant was measured by vascular ultrasound. Symptom scores, FMD values, and head-up test (HUT)/head-up tilt test (HUTT) outcomes were investigated before and after treatment. A receiver operating characteristic curve was used to explore the value of FMD as a predictor. Baseline FMD (%) and increased heart rate (beats per minute) during HUT/HUTT were significantly greater in children with POTS compared with control children (FMD: 11 ± 3% vs 6 ± 2%, p <0.001; increased heart rate: 38 ± 9 vs 7 ± 7 beats/min, p <0.001, respectively). Before treatment, MD responders had greater FMD values than MD nonresponders (p <0.05). Symptom scores, excessive increases in heart rate during HUT, and increased FMD values were all reduced significantly after treatment (all p <0.05). The receiver operating characteristic curve for the predictive value of FMD showed the area under the curve to be 0.790 (95% confidence interval: 0.679 to 0.902; p <0.001) at 1-month and 0.803 (95% confidence interval: 0.669 to 0.936; p <0.01) at 3-month therapy. FMD of 9.85% had a high sensitivity (1-month therapy: 71.6%; 3-month therapy: 74.4%) and specificity (1-month therapy 77.8%; 3-month therapy: 80%). In conclusion, FMD is a predictor of the efficacy of MD for treating children with POTS.

  9. Therapeutic benefit of lentiviral-mediated neonatal intracerebral gene therapy in a mouse model of globoid cell leukodystrophy.

    Science.gov (United States)

    Lattanzi, Annalisa; Salvagno, Camilla; Maderna, Claudio; Benedicenti, Fabrizio; Morena, Francesco; Kulik, Willem; Naldini, Luigi; Montini, Eugenio; Martino, Sabata; Gritti, Angela

    2014-06-15

    Globoid cell leukodystrophy (GLD) is an inherited lysosomal storage disease caused by β-galactocerebrosidase (GALC) deficiency. Gene therapy (GT) should provide rapid, extensive and lifetime GALC supply in central nervous system (CNS) tissues to prevent or halt irreversible neurologic progression. Here we used a lentiviral vector (LV) to transfer a functional GALC gene in the brain of Twitcher mice, a severe GLD model. A single injection of LV.GALC in the external capsule of Twitcher neonates resulted in robust transduction of neural cells with minimal and transient activation of inflammatory and immune response. Importantly, we documented a proficient transduction of proliferating and post-mitotic oligodendroglia, a relevant target cell type in GLD. GALC activity (30-50% of physiological levels) was restored in the whole CNS of treated mice as early as 8 days post-injection. The early and stable enzymatic supply ensured partial clearance of storage and reduction of psychosine levels, translating in amelioration of histopathology and enhanced lifespan. At 6 months post-injection in non-affected mice, LV genome persisted exclusively in the injected region, where transduced cells overexpressed GALC. Integration site analysis in transduced brain tissues showed no aberrant clonal expansion and preferential targeting of neural-specific genes. This study establishes neonatal LV-mediated intracerebral GT as a rapid, effective and safe therapeutic intervention to correct CNS pathology in GLD and provides a strong rationale for its application in this and similar leukodystrophies, alone or in combination with therapies targeting the somatic pathology, with the final aim of providing an effective and timely treatment of these global disorders.

  10. Phenylbutyrate counteracts Shigella mediated downregulation of cathelicidin in rabbit lung and intestinal epithelia: a potential therapeutic strategy.

    Directory of Open Access Journals (Sweden)

    Protim Sarker

    Full Text Available BACKGROUND: Cathelicidins and defensins are endogenous antimicrobial peptides (AMPs that are downregulated in the mucosal epithelia of the large intestine in shigellosis. Oral treatment of Shigella infected rabbits with sodium butyrate (NaB reduces clinical severity and counteracts the downregulation of cathelicidin (CAP-18 in the large intestinal epithelia. AIMS: To develop novel regimen for treating infectious diseases by inducing innate immunity, we selected sodium 4-phenylbutyrate (PB, a registered drug for a metabolic disorder as a potential therapeutic candidate in a rabbit model of shigellosis. Since acute respiratory infections often cause secondary complications during shigellosis, the systemic effect of PB and NaB on CAP-18 expression in respiratory epithelia was also evaluated. METHODS: The readouts were clinical outcomes, CAP-18 expression in mucosa of colon, rectum, lung and trachea (immunohistochemistry and real-time PCR and release of the CAP-18 peptide/protein in stool (Western blot. PRINCIPAL FINDINGS: Significant downregulation of CAP-18 expression in the epithelia of rectum and colon, the site of Shigella infection was confirmed. Interestingly, reduced expression of CAP-18 was also noticed in the epithelia of lung and trachea, indicating a systemic effect of the infection. This suggests a causative link to acute respiratory infections during shigellosis. Oral treatment with PB resulted in reduced clinical illness and upregulation of CAP-18 in the epithelium of rectum. Both PB and NaB counteracted the downregulation of CAP-18 in lung epithelium. The drug effect is suggested to be systemic as intravenous administration of NaB could also upregulate CAP-18 in the epithelia of lung, rectum and colon. CONCLUSION: Our results suggest that PB has treatment potential in human shigellosis. Enhancement of CAP-18 in the mucosal epithelia of the respiratory tract by PB or NaB is a novel discovery. This could mediate protection from

  11. Trappings of femininity: A test of the "beauty as currency" hypothesis in shaping college women's gender activism.

    Science.gov (United States)

    Calogero, Rachel M; Tylka, Tracy L; Donnelly, Lois C; McGetrick, Amber; Leger, Andrea Medrano

    2017-03-17

    This study investigated whether believing beauty is a primary currency for women operates as an antecedent force in the relation between self-objectification and gender activism. Ninety-four ethnically diverse women attending a small liberal arts college in the southeastern United States completed the study questionnaires online for course credit. Preliminary results demonstrated beauty as currency belief, self-objectification, and support for the gender status quo were negatively associated with gender activism. A serial mediation analysis revealed support for the proposed model: Beauty as currency belief was indirectly and inversely linked to gender activism through self-objectification and support for the gender status quo, offering initial evidence for our beauty as currency hypothesis. These findings suggest belief in the notion women will reap more benefits from their bodies than other attributes or pursuits may be an important legitimizing feature of feminine beauty ideology that works through self-objectification against gender social change.

  12. CULTURE-SPECIFIC CONCEPTUALISATIONS OF BEAUTY

    OpenAIRE

    Харлай, О. В.

    2017-01-01

    From the perspective of cultural linguistics, this paper a) investigates and compares the conceptualisations of beauty in the Chinese, English and Slavonic (Polish and Ukrainian), b) analyses the cultural contexts of in which beauty conceptualises and c) reveals the crucial peculiarities of the human’s perception and evaluation of beauty in the appointed languages. Based on the theory that language is an activity the character and structure of which express the culture and individuality of sp...

  13. Beauty and critical art: is beauty at odds with critical–political engagement?

    Directory of Open Access Journals (Sweden)

    Maria-Alina Asavei

    2015-06-01

    Full Text Available Traditionally, beauty is understood as an ability of some objects (artworks included to occasion in viewers a distinctive type of unmediated/pure pleasure—aesthetic pleasure. According to this common understanding of beauty, political–critical art does not seem to raise in viewers the feeling of aesthetic pleasure. Many contemporary critical artists and politically engaged artists deliberately produce an art as unappealing to the senses as possible (their attitude could be called, following Arthur Danto, kalliphobia—“beauty phobia”. Critical art is a type of art which usually does not strike us with beauty at first sight because this “political art” usually deals with issues of social injustice and political struggles, rendering contemplation and aesthetic pure pleasure unachievable. Yet, even if beauty, in critical art's case, seems to be a difficult, demanding, and not an immediately recognisable one (mostly because of its unappealing, unsettling look, this does not mean that it lacks or is at odds with critical engagement (as some critical artists and theorists have argued. The argument of this paper is that not every beautiful thing looks good at first sight. By the same token, not everything that looks beautiful is in fact beautiful. Drawing on Immanuel Kant's neglected pulchritude adhaerens (dependent beauty, I argue that political–critical art is characterised by a dependent type of beauty (beauty a thing has as a thing of a certain kind and with a certain function as opposed to free beauty (as something we like it freely on its own account, independent of what it is and what it does. Political–critical art can claim a dependent beauty (an impure, “difficult” and not straightforward pleasurable type of beauty without being compelled to submit itself, at the same time, to the free beauty.

  14. The realization of absolute beauty: an interpretation of the fairytale Snow White.

    Science.gov (United States)

    Takenaka, Nanae

    2016-09-01

    This paper interprets the fairytale Snow White (Bruder Grimm 1857) in terms of the realization of absolute beauty. Jung's understanding that 'in myths and fairytales, as in dreams, the soul speaks about itself' (Jung 1945, para. 400), underpins such an approach. From this perspective a fantasy image is not about us, not about our unconsciousness, but is essentially about itself. The idea of absolute beauty first arises in the Queen's mind as a wish. Despite the Queen's strong desire to be named as the most beautiful person in the world, her mirror reflects that it is actually her daughter Snow White who is the fairest. Snow White might be regarded in the language of Giegerich as her internal other. Effectively they are separated into the Real that conceives the idea of absolute beauty and the Ideal that embodies it. The exchange that takes place between the two - mediated by mirror and window - generates the corpse of surpassing beauty that never decays but lies inaccessible behind the glass coffin. However the loving and penetrating gaze of the Prince, representing masculinity, succeeds in reanimating Snow White. Thus the Prince as the Other that is completely external and unknown to both the Queen and Snow White, specifically to their femininity, facilitates the realization of absolute beauty as the Ideal in the Real.

  15. The challenges and beauty of peripheral nerve regrowth.

    Science.gov (United States)

    Zochodne, Douglas W

    2012-03-01

    This review provides an overview of selected aspects of peripheral nerve regeneration and potential avenues to explore therapeutically. The overall coordinated and orchestrated pattern of recovery from peripheral nerve injury has a beauty of execution and progress that rivals all other forms of neurobiology. It involves changes at the level of the perikaryon, coordination with important peripheral glial partners, the Schwann cells, a controlled inflammatory response, and growth that overcomes surprising intrinsic roadblocks. Both regenerative axon growth and collateral sprouting encompass fascinating aspects of this story. Better understanding of peripheral nerve regeneration may also lead to enhanced central nervous system recovery.

  16. Perceiving beauty in all women: Psychometric evaluation of the Broad Conceptualization of Beauty Scale.

    Science.gov (United States)

    Tylka, Tracy L; Iannantuono, Amy C

    2016-06-01

    Women's ability to broadly conceptualize beauty (i.e., perceive many looks, appearances, body sizes/shapes, and inner characteristics as beautiful) has been identified as a facet of positive body image in qualitative research. A scale is needed to be able to assess this construct within quantitative research. Therefore, we developed the Broad Conceptualization of Beauty Scale (BCBS), which measures the extent women define female beauty widely within external and internal characteristics, and examined its psychometric properties among four community samples totaling 1086 women. Exploratory and confirmatory factor analyses revealed a unidimensional structure with nine items. The internal consistency, test-retest reliability, and construct (convergent, discriminant, and incremental) validity of its scores were upheld. Researchers and clinicians can use the BCBS alone to assess women's perceptions of female beauty, or they can use the BCBS alongside women's perceptions of self-beauty to more comprehensively explore women's ability to broadly conceptualize beauty for others and themselves.

  17. Free Harmonious Beauty of Greek Sculpture

    Institute of Scientific and Technical Information of China (English)

    郑晓杨

    2015-01-01

    Greek art in the content and form of the art of the beautiful, harmonious effect fully expresses the interpretation of the height of the spirit of freedom, and the Greek sculpture is a powerful representative of Greek art. In this paper, from a few large sculpture art to savor the Greek sculpture artistic freedom and harmonious beauty.

  18. Is Beauty an Archaic Spirit in Education?

    Science.gov (United States)

    Cannatella, Howard

    2006-01-01

    This article discusses the unfashionable and taboo idea that beauty matters. The author's supposition is that beauty as a poetic force should be regarded as one of the defining characteristics central to pedagogic practice. In making this claim he draws upon a few of Charles Dickens' and William Wordsworth's ideas in support of the importance of…

  19. ATTRACTION OF STUDENTS TOWARDS BEAUTY PRODUCTS

    Directory of Open Access Journals (Sweden)

    Fouzia Ali

    2011-07-01

    Full Text Available The purpose of this study was to measure the correlation and impact of deceptive beauty advertising (Ads with and on the buying behavior of the university students toward beauty products. Developed instrument contained nineteen questions. Five point Likert scale was used and the response rate was 94.667%. Two variables were computed; buying behavior of university students towards beauty products was dependent variable; and deceptive beauty ads were independent variable. Descriptive statistics, correlation and liner regression techniques were used with the help of SPSS 16. Positive and significant correlation and impact was found with and on the buying behavior of university students toward beauty products which means that the use of beauty products increases with the increase in deception in beauty products ads. The data were collected from university students and non-serious attitude of students were the limitations of this study. In this study, the main focus was on the buying behavior of students and beauty products ads, and it will serve as a benchmark for prospective researchers for future study.

  20. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Kidd Ji

    2010-01-01

    <正>01逆转光老化>光老化是目前被认为肌肤衰老的最大元凶。有害的紫外线深入肌肤深处,直接伤害细胞DNA,破坏肌肤自我更新过程,同时引发自由基,对肌肤造成进一步的间接伤害。在美国,激光被运用在光老化引起的皱纹、松弛的肌肤治疗上,因为术后红肿的反应并不多,所以很多人都能接受。但你需要为之付出疼痛感和一到两万元的高额费用。随着美容产品技术的提高与开发,基于医学美容的CLINIQUE

  1. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie Kwok

    2012-01-01

    <正>01皇室御用彩妆盒〉Cle de peau Beaute邀得皇室御用珠宝设计师Shaun Leane,为春夏特别推出的Luminizing Face Enhancer设计一个闪烁夺目的盒子。Shaun Leane曾任皇室御用珠宝师及Alexander McQueen的首席珠宝设计师。他是英国FlPG获奖者,该奖项专门表扬技术超凡的珠宝匠师。精美闪烁的宝石切割面粉盒,一丝不苟的设计,令彩妆盒精致如珠宝盒一样,带有高贵优雅气派。Shaun Leane指出:"最初构思包装设计时,第一个念头是塑造既富触感又美观的盒子。在美感方面,我们希望设计宛如一件多琢面的

  2. Beauty

    Institute of Scientific and Technical Information of China (English)

    Jasmine; Chris

    2010-01-01

    <正>03Jean Paul Gaultier 2010春夏高级订制:梦游"奇幻乐园"〉老顽童Jean Paul Gaultier这次给彩妆大师Tom Pecheux出了一个趣味横生的妆容课题—fantasy land。于是Tom Pecheux把墨西哥人、外星人、甚至是热映的电影《Avatar》都搬上了T台。模特们的妆容被大自然的缤纷色彩所填满,限部以天空蓝、植物绿、夕阳橙和大地黄为

  3. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie; Kwok

    2011-01-01

    <正>01从不泛黄的照片谈美白>现在什么都谈数码化,数码相机的科技水平也越来越高,但是十分值得纪念的相片,还是会有冲印出来的冲动。富士牌的相机胶卷你一定听过用过吧,用它冲印出来的相片,不论经过多少年,相片上的颜色不只没有泛黄,更没有褪色。原来,照相的相机胶卷是用骨胶原制成的。相同道理,如果富士能将相机胶卷用的骨胶原保持最佳状态,它们亦会知道怎样保护我们皮肤的骨胶原。所以当富士推出Fijifilm beauty系列,对女士们来说,可谓福音!

  4. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie; Kwok

    2011-01-01

    <正>01有机"炼金术">古时人们相信可以从金属中提炼长生不老的丹药,虽然现代科学已证实炼金术不能提炼所谓"仙丹",但却令人类对物质和化学有了进一步的认识和了解。因为这些知识,让我们可以从自然环境中萃取各种天然成分,合成及研发成各种不只对皮肤或身体有益的产品,更有效地减少了浪费和不必要的消耗。

  5. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Kidd Ji

    2010-01-01

    <正>01Rene Gruau与美妆传承法国画家Rene Gruau的重要,不仅来自他独特的虚实结合水彩风格,将东西方绘画艺术相结合,令20世纪中期的人们耳目一新。他与Dior品牌合作,让插画与Dior在50年代推出的"New Look"风格紧密结合,流畅大气的线条勾勒出明显的女性曲线,修身、高雅、大气,这些插画与人们脑中的Dior服饰产生了不可分割的联系。2010年11月10日至2011年1月9日,名为"Dior插画展:Rene Gruau与美妆传承"的展览将于伦敦萨默塞特宫隆重举行。这场展览将向公众展现里程碑式的艺术珍品,荟集了经严格甄选的Dior高级定制礼服,以及Gruau特别为Dior香水化妆品品牌、古董香水瓶、时装手绘稿和杂志精心绘就的原创插画。六位英国出生的插画家亦将应邀在此次展览中展示画作,Gruau与Dior迪奥品牌的无间合作正是他们的灵感源泉。

  6. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Chris

    2010-01-01

    <正>01至真"纸"美>美国时装真人秀节目《Project Runway》在最近的一期节目里,请参赛者们用牛皮纸来代替寻常的布料,做出属于自己的牛皮纸时装,结果平时表现平平的参赛者都发挥得不错。原因何在?牛皮纸那朴实无华,却坚韧有型的特色赋予了"材料"更多的可塑性,同时也呼应了当下全球大热的

  7. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Chris

    2010-01-01

    <正>01DNA科技注入睫毛膏>在护肤品中添加生物基因技术,已不再是什么大新闻。但你听说过,在睫毛膏里也加入这一科技吗?7月即将问市的Lancome全新梦魅臻采睫毛膏,就以兰蔻高科技研究成果为基础,加入了独一无二的基因配比技术,用以启动睫毛干细胞的活性,促进干细胞新生,仿佛为睫毛注入第二次生命般,让睫毛变长变密。同时,特别研制的刷头,可以更好的让膏体和睫毛接触,达到更完美的浓睫艳眸效果。www.lancome.com

  8. Beauty

    Institute of Scientific and Technical Information of China (English)

    Jasmine; Chris

    2010-01-01

    <正>01沪上定制妆容〉香奈儿巴黎——上海高级手工坊将时尚大帝Karl Lagerfeld和彩妆大师Peter Philips都带来了上海,除了为上海度身定做的华服之外,那颇有东方韵味的妆容也令人印象深刻。Peter在采访中透露这次妆面的灵感来自Karl给他看的一部电影——《花样年华》。模特们的妆容需要看上去既要有像张曼玉穿旗袍时的优雅,又能表现出如未来女战士般的魄力。正如服装秀一开场,模特们所穿着服装的灵

  9. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Paris; Sun

    2011-01-01

    <正>01Aesop来自澳洲的"伊索寓言">"伊索寓言"在巴黎上演,Aesop巴黎店最新橱窗展,伊索灵魂漫游于方寸橱窗间。成立于1987年的澳洲品牌伊索(Aesop),在纯天然植物护肤的基础上率先推行有机理念,并结合内外调理的"理智"生活哲学。出身于拥有最多濒临绝种的奇花异草、珍禽怪兽的澳大利亚净土,品牌从研发、测试到

  10. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Jasmine; Chris

    2010-01-01

    <正>022010 Chanel春夏高级成衣发布会后台彩妆探秘在这场仿佛是法国皇后Marie Antoinette在凡尔赛宫的小农庄重现的时装秀上,除了精致奢华的新款时装令人眼前一亮之外,彩妆创意总监Peter Phillips在妆容上也为我们带来了新一年的流行趋势,那就是以高雅别致的米色调为主,打造令人耳目一新、清新富有朝气的妆容。这种邻家女孩味十足的妆容效果,基本适合所有的女性,所有的场合。如果你嫌妆容过于"平淡",那

  11. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie Kwok

    2012-01-01

    <正>01好莱坞巨星的活肤秘诀>由匈牙利皮肤科医生Dr.Laszlo创办的纽约品牌Emo Laszlo,一直深受皇室名人及好莱坞巨星的喜爱,今年是Emo Laszlo创立八十五周年,特别以五位家喻户晓的好莱坞女星为灵感,推出八十五周年限量版好莱坞尊贵系列。五款尊贵系列的原装产品分别为珍珠亮采唤肤啫喱、魅惑水润修护眼霜、Refresh尊贵宝石再生补湿霜、搪瓷肌抗氧化修护霜及丝滑

  12. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Jasmine; Chris

    2009-01-01

    <正>01寻找秋冬发型灵感>Aveda刚发表了新一季发型及发色潮流造型照,品牌的环球创作总监Antoinette Beenders介绍这系列灵感启发自80年代的歌德式华丽,他说:"今季的造型设计大量运用了复古味极浓的经典剪裁和发色。"一如以往,Aveda的造型设计无论是发型及发色都相当实用,参考价值甚高,想改变造型又没有头绪的话,可到品牌的网址找找合心意的发色与发型,更有来自世界各地的造型师所提供的理发建议。除此之外,可留意这辑造型照的另一个特别之处:模特儿所穿的礼服,全采用可循环再用的物料制造,如旧报纸、旧牛仔布料及风衣等,重新解构再造,非常合乎Aveda的环保原则。

  13. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Kidd; Ji; Paris; Sun

    2011-01-01

    <正>01一片蓝心向北非Giorgio Armani用一种颜色完成了2011春夏女装秀,撒哈拉沙漠中部游牧民族图阿雷格人的文化就是其女装的灵感来源。而品牌彩妆的特质在于其质感和色彩都基于时装的灵感、布料的材质之上。2011年春夏妆容,其灵感同样延续来自图阿雷格人面纱的颜色——靛蓝。设计师Giorgio Armani认为:"蓝与黑的搭配会让经典的黑色更有生命力。"通过对蓝色和黑色搭配的重新诠释,赋予了品牌招牌式优雅更富故事性与情境感的篇章。

  14. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie; Kwok

    2011-01-01

    <正>01植村秀东京眼妆美学〉植村秀这彩妆品牌相信是不少潮流达人的心头好,不只因为其一流品质,更因为品牌从来以"不停构思改进与发掘"为哲学,不断推陈出新。今季炎夏,配合自由配搭彩妆盒,及全新系列眼影色系,品牌打造个人独特的彩妆盒。彩妆盒由日本著名建筑师干久美子设计,简洁优雅之余,亦令彩妆盒不需使用任何黏贴工具,亦能轻松替换眼影及胭脂组合。

  15. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Chris

    2010-01-01

    <正>01帝王之水典藏版华丽开售>现在你不必亲身飞到巴黎或香港等地,Guerlain巴黎之家专属限量香氛上海梅龙镇伊势丹精品专柜店将在7月隆重揭幕。作为国内唯一一家精品店,也是香榭丽舍大道68号LaMaison Guerlain娇兰之家的华丽缩影,在此你可以独家购买到帝王之水金箔蜂姿琉金典藏版等多款限量版香水。帝王之水乃品牌创始人Pierre Francois Pascal为法国Eugenie皇后特别制作的新婚礼物,清新、芬芳而怡神的它,是橙花、香橼、柠檬、

  16. Beauty

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

    <正>眉:自然生态眉首先要扭转精致、服帖、细长才是完美眉形的观念。选择比发色淡一度的眉粉自下眉头处1cm处为起点,向眉峰轻扫,进而顺延至眉尾,别忘记用余粉将眉毛边缘处做好过渡。最后用眉形修饰膏以先顺再逆的方向梳理眉毛,缔造根根分明的印象。眼:亚洲人的内陷式双眼皮,令彩色眼线往往不足以提升眼晴的精气神。双色眼线以深色在靠近内眼睑的位置铺底,此处精细和轻巧的眼尾上挑是关键,然后用明媚的彩色眼线以略宽出1~2cm的方式勾勒,霎时拥有明眸点睛的魅惑力。

  17. Beauty

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    一年之中,可以好好重整肌肤状况的有两个时段,分别是3,4月和10,11月,这两个时节,肌肤刚从剧烈的换季变化中回复平稳,最适合趁机除去累积的废物,并补充肌肤所需的营养,就像大病之后需要恢复元气一样。

  18. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    <正> 今年起,说到最有效的抗氧化成分,你脑中该留下一个新名词"IDEBENONE 艾地苯"。这种由 ELIZABETH ARDEN 携手 BOTOX 肉毒杆菌素的创造者——ALLERGAN 联手推出的新成分已被运用在"PREVAGE 逆时橘灿精纯凝露"中,掀起了全球医学美容热潮。被称为"抗氧化超人"的它在18岁后即可每天使用,对抗光老化及预防皱纹。

  19. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    2014-01-01

    <正>眼部的流线美学2014秋冬的T台妆容,醒目又流畅的眼妆深入人心,能够一根根修饰睫毛的睫毛刷,触感光滑柔软的丝绒效果眼影,勾勒夸张猫眼效果的厚泽眼线,所有的产品都重在打造自然流畅中可扩大眼形的清秀眼妆。01细致巧妙地提亮肌肤疲惫黯淡区域圣罗兰明彩笔1#2.5ml/RMB36002柔滑质感与千变万化的妆效圣罗兰臻彩四色眼影5#5g/RMB56003惊艳系列,打造含情脉脉的眼神迪奥单色眼影3g/RMB31004打造诱惑双眸的波普粉色迪奥魅惑睫毛膏9ml/RMB36005精致珍珠母贝令双眸晶莹闪亮希恩黎植物炫彩眼影06极其柔软,幼滑的眼线笔希思黎植物丝缎眼线笔

  20. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie; Kwok

    2011-01-01

    <正>01闪耀细胞思维论〉Cle de Peau Beaute认为每一个皮肤细胞,犹如脑细胞一样,能够自我思考。它们均具有处理各种情报的能力,只要有效管理细胞使之接收更多正面讯息,阻截负面情报,提升肌肤本身的机制优化细胞机能,便能诱导更多正面讯息能量的吸收,从而改善皮肤质量。而全新Basic Care系列,便是因应闪耀细胞管理而研发。

  1. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie; Kwok

    2011-01-01

    <正>01Burberry Body全新香氛>Burberry Body找来英国女演员兼模特儿Rosie Huntington-Whiteley,让她成为品牌的第一位代言人,从她身上完美地体现出感性、自信和谦逊的平衡。全新香氛使用的成分亦不简单,除了以天然玫瑰精油和香草为基调外,前调的苦艾酒曾一度是欧洲禁酒,也是梵高每次画画必喝的最爱。品牌还在香水瓶上花了不少心思,品牌刨作总监Christopher Bailey表示:"我常将

  2. Beauty

    Institute of Scientific and Technical Information of China (English)

    Katie Kwok

    2012-01-01

    <正>01澳大利亚有机美发>澳大利亚天然资源丰富,所以不少美容品牌都从当地的有机农庄获取原材料,主要因为有机草本成分内含的维他命、矿物质等营养成分比非有机草本植物高,同时有助减少吸收不必要的抗生素、农药等化学成分,令消费者更安心使用。澳洲进口品牌australian organics,在澳洲拥有十五年历史,产品包括面部护理、沐浴及身体护理以及头发护理系列。其有机成分获澳洲国家可持续农业协会机构(NASAA)认可,并属澳洲低碳产品商认可成员,全部产品均于澳洲制造,绝对不含石化成分、人造香料、色素及任何基因改造和动物测试,成分温和,容易吸收,特别适合亚洲人肌肤。品牌根据不同发质及肌肤需要,以天然草本成分调配不同配方外,亦以舒缓、减压、安抚情绪、助眠等有机香熏精华调配而成,让秀发及头部皮肤获得细致呵护之余,于感官上也同时得到洗涤,令日常护理程序变得更轻松。

  3. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie Kwok

    2012-01-01

    <正>01蜗牛美容秘辛〉早于1980年,智利皮肤科医生Mr.Fernando Bascunan就已发现蜗牛分泌物具有非凡的护肤功效。当时他的家族以养殖蜗牛为生,并出口至欧洲各国成为美食。多年来在处理蜗牛的过程中,Fernando Bascunan意外地发现,工人被工具刮伤的患处不但没有发炎伤口愈合会更快,也不会留下疤痕。自此以后,他就开始对蜗牛进行研究,发现蜗牛黏液可在人类皮肤上产生嫩肤、再生及修复的神奇功效。近年来不少美容品牌都开始投放资源,研发蜗牛黏液护肤品,其中来自韩国的MISSHA,以韩国锦

  4. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Kidd Ji

    2010-01-01

    <正>01Chanel 2010 Couture Makeup在高级订制服的秀场上,时装及配饰不但影响着未来一至两季的服装潮流,模特的妆容作为整个系列的点睛之笔,也对妆容的流行指明方向。由Chanel全球彩妆创意总监Peter Philips为秋冬高级订制系列创作的红色概念妆容就是其中一个例子。Peter Philips表示,他的设计概念来自Karl Lagerfeld向他展示的设计草图:"我发现他在所有的模特嘴上都加上了一抹红色。而他展示给我看的第一件外套也是红色

  5. Beauty

    Institute of Scientific and Technical Information of China (English)

    James; Stephen; Behrens; 王海强

    2006-01-01

    古往今来,人们一直通过语言、艺术或思考来探究人生的真谛。有人以追求人生的真理为乐,甚至是舍生取义;也有人在追求真理的过程中不断完善自己的生命。本文以朴实的文笔娓娓述说了一个令人深思而嗟叹的故事。故事女主人公相貌丑陋,但却以她独特的灵气、细腻的美感、动人的话语征服了人心。她对待人生的态度和生活的勇气,无疑会令所有的身体健康者汗颜!

  6. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie; Kwok

    2011-01-01

    <正>01台湾有机>说起护肤品的出产地,瑞士美国等欧美传统美容王国当然占市场大部分位置,但有时候因气候水土不同,在美国用起来一流的产品,来到亚洲可能就要大打折扣。近年除了韩国,台湾出产的美容护肤产品亦大受欢迎,除了一流的质量外,价位亦十分相宜。以统欣生物科技公司旗下品牌之一Deary媞尔妮为例,在身体及脸部保养品领域开发专研,以有机草本原料,配合独特研发技术,其面膜销售更是台湾连锁便利店排行第一。统欣生物科技公司,除了研发有效的护肤品之余,亦对护

  7. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Kidd Ji

    2010-01-01

    <正>01悦木之源"眼咖啡">一直以为,累了、困了只要一杯咖啡就能提神解乏。却没想到,咖啡的活力还能喂进眼睛里,仿佛永远没有睡醒的倦怠双眼,在遇见悦木之源人参活力焕亮眼霜之后便能苏醒。这款在业界素有"精神眼霜"、"眼咖啡"、"加班眼霜"等众多俏皮昵称的Origins GinzingTM人参活力焕亮眼霜优选两款醒神植物能量——"百草之王"人参与"醒神之王"咖啡,同时融汇了冬虫夏草、木兰花、锦紫苏、橙皮苷、黄芩、绿茶等多种活力秘方,能够有效针对改善黑眼圈、眼部浮肿和眼疲劳等眼部问题,仿佛给倦眼来一杯Espresso。

  8. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Chris

    2010-01-01

    <正>01Christian Dior贵族淑女踏春归来随着马蹄声的配乐响起,Christian Dior宣布贵族淑女的时代回归。绣花、珍珠、花朵这些春意盎然的细节都运用到了薄纱以及各种轻盈的材质上。马鞭与马靴还有骑马的高帽搭配着长裙,优雅帅气的骑士装扮瞬间抓住了在场女士们的心。在妆容上,化妆师

  9. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie Kwok

    2012-01-01

    <正>01摩诃之美>摩诃本为梵文,在佛教中有超越有情与无情,在无边无际、有形与无形之间显得圆通神妙用的意思。正如Cle de PeauBeaute秋冬妆容系列,以光亮色彩从黑暗中反映出来,以阴影映衬着明亮的双眸,以光泽衬托出不一样的色彩。品牌的彩妆美容形象师Lucia Pieroni说:"色彩在黑暗中绽亮生辉,令眼影细滑如丝。炯炯有神的明眸,在色彩与质感交织下美丽迷人,映照神秘的黑夜。"而系列最新三款让人惊艳的眼影色调,以散发不同光芒的珠光组合塑造聚光焦点,色彩中若隐若现的光泽,在瞳孔中映照出神秘光芒,演绎高贵优雅的魅力。色调可随意混配,

  10. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Kidd; Ji; Paris; Sun

    2011-01-01

    <正>01纸艺幻发纸艺能成为备受关注的艺术形态,是因为纸本身拥有轻盈及可塑性强的特质,再配合极富想象力的创作,即能呈现出千变万化的视觉形象,承载无限艺术价值。沙宣认为头发与纸艺的创作概念如出一辙,今年冬季亦从纸艺中汲取灵感,设计出了轻盈、可塑的概念发型。以"逆重幻觉"为名的发型特辑借用纸艺"挣脱重力的束缚仿佛能够对抗万有引力的存在"这一概念,丰盈的发型在充满空气感的同时,造型上也十分具有纸张所带来的结构感。当被问及如何打造这样的发型时,其创意总监回答:"关键在于拥有轻盈可塑的健康秀发。"道理虽不难,达到却不易。

  11. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie Kwok

    2012-01-01

    <正>01世界海洋大同>La Mer的世界海洋日活动,不仅要提升大家对海洋美态和修复力量的关注,更要呼吁人们对它脆弱的生态多加爱惜。La Mer相信海洋植物如太平洋海藻,其惊人力量尚未被完全发掘及理解,所以我们应全力支持生态保育,为下一代守护并保存这大自然的瑰宝。今年的世界海洋日活动鼓励大众探索、发掘和欣赏海洋宝库。La Mer特别设计了一百毫升的世界海洋日Creme de la Mer限量版面霜,瓶身设计的灵感亦撷取

  12. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie Kwok

    2012-01-01

    <正>01意大利大家闺秀>Valentino除了经典的火红女郎形象外,近年时装秀的蕾丝都充分表现出品牌对女性妩媚的诠释。而今次Valentino的首支吞氛更是为其女性时装及生活方式所启发。为了这支香氛像是一束综合了多种鲜花精炼而成的香味,选用的材料都极度女性化,充分代表了Valentino女性的独特气质,因此便以Valentina命名。品牌邀两位杰出的调香师:Oliver Cresp

  13. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie; Kwok

    2011-01-01

    <正>01抗敏医美学>据说橄榄树非常长寿,可以健康地存活1000年,所以科学家相信橄榄树含有保持青春的成分,知名的皮肤科医生及抗衰老专家Nicholas Perricone博士研发的Perricone MD护肤品牌,就是以橄榄叶及其果实的天然分子橄榄多酚为敏感肌肤带来有效护理的抗衰老系列。

  14. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie Kwok

    2012-01-01

    <正>01救生员认可的有机防晒美国生态环境研究专家Chris Birchby的家人,不幸患上黑色素瘤,令他明白防晒的重要,同时作为生态环境研究专家,他亦希望护肤品不会加重地球的负担,所以研发出防晒品牌COOLA,以有机天然成分为主,同时以物理性及化学性的防晒配方,推出高效的防晒产品,除了获得各个有机认证外,亦获得美国救生员协会的认可。

  15. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Paris; Sun

    2011-01-01

    <正>01美妆拜占庭拜占庭艺术(Byzantine art)指东罗马帝国的艺术。大体来说,所有拜占庭的艺术都充满了精神的象征主义。重视心象,不容有写实主义的存在。为配合Chanel巴黎一拜占庭高级手工坊系列成衣发布,Chanel全球彩妆创意总监彼德·菲利浦斯以世界知名的狄奥多拉女皇Theodora的马赛克肖像图为灵感创作了一组妆容,而肖像图中女皇眉峰部分所描绘的红色眼影线条,被他用作了这次妆

  16. Ibrutinib interferes with the cell-mediated anti-tumor activities of therapeutic CD20 antibodies: implications for combination therapy

    DEFF Research Database (Denmark)

    Da Roit, F.; Engelberts, P. J.; Taylor, R. P.

    2015-01-01

    -treatment with ibrutinib did not inhibit complement activation or complement-mediated lysis. In contrast, ibrutinib strongly inhibited all cell-mediated mechanisms induced by anti-CD20 antibodies rituximab, ofatumumab or obinutuzumab, either in purified systems or whole blood assays. Activation of natural killer cells...

  17. Health and Beauty Magazine Reading and Body Shape Concerns among a Group of College Women.

    Science.gov (United States)

    Thomsen, Steven R.

    2002-01-01

    Examines three potential factors that might mediate the relationship between reading women's magazines and body shape and size concern. Finds that health and fitness magazine reading by college-aged women was linked directly to body shape concerns, indirectly through beliefs about men's thinness expectations. Explains that beauty and fashion…

  18. Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells

    Directory of Open Access Journals (Sweden)

    Liz J. Valente

    2016-03-01

    Full Text Available Nutlin3a is a small-molecule antagonist of MDM2 that promotes non-genotoxic activation of p53 through p53 protein stabilization and transactivation of p53 target genes. Nutlin3a is the forerunner of a class of cancer therapeutics that have reached clinical trials. Using transgenic and gene-targeted mouse models lacking the critical p53 target genes, p21, Puma, and Noxa, we found that only loss of PUMA conferred profound protection against Nutlin3a-induced killing in both non-transformed lymphoid cells and Eμ-Myc lymphomas in vitro and in vivo. CRISPR/Cas9-mediated targeting of the PUMA gene rendered human hematopoietic cancer cell lines markedly resistant to Nutlin3a-induced cell death. These results demonstrate that PUMA-mediated apoptosis, but not p21-mediated cell-cycle arrest or senescence, is a critical determinant of the therapeutic response to non-genotoxic p53 activation by Nutlin3a. Importantly, in human cancer, PUMA expression may predict patient responses to treatment with MDM2 antagonists.

  19. Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells.

    Science.gov (United States)

    Valente, Liz J; Aubrey, Brandon J; Herold, Marco J; Kelly, Gemma L; Happo, Lina; Scott, Clare L; Newbold, Andrea; Johnstone, Ricky W; Huang, David C S; Vassilev, Lyubomir T; Strasser, Andreas

    2016-03-01

    Nutlin3a is a small-molecule antagonist of MDM2 that promotes non-genotoxic activation of p53 through p53 protein stabilization and transactivation of p53 target genes. Nutlin3a is the forerunner of a class of cancer therapeutics that have reached clinical trials. Using transgenic and gene-targeted mouse models lacking the critical p53 target genes, p21, Puma, and Noxa, we found that only loss of PUMA conferred profound protection against Nutlin3a-induced killing in both non-transformed lymphoid cells and Eμ-Myc lymphomas in vitro and in vivo. CRISPR/Cas9-mediated targeting of the PUMA gene rendered human hematopoietic cancer cell lines markedly resistant to Nutlin3a-induced cell death. These results demonstrate that PUMA-mediated apoptosis, but not p21-mediated cell-cycle arrest or senescence, is a critical determinant of the therapeutic response to non-genotoxic p53 activation by Nutlin3a. Importantly, in human cancer, PUMA expression may predict patient responses to treatment with MDM2 antagonists.

  20. Beauty and Cuteness in Peripheral Vision

    Directory of Open Access Journals (Sweden)

    Kana eKuraguchi

    2015-05-01

    Full Text Available Guo, Liu, & Roebuck (2011 showed that attractiveness was detectable in peripheral vision. Since there are different types of attractiveness (Rhodes, 2006, we investigated how beauty and cuteness are detected in peripheral vision with a brief presentation. Participants (n = 45 observed two Japanese female faces for 100 ms, then were asked to respond which face was more beautiful (or cuter. The results indicated that both beauty and cuteness were detectable in peripheral vision, but not in the same manner. Discrimination rates for judging beauty were invariant in peripheral and central vision, while discrimination rates for judging cuteness declined in peripheral vision as compared with central vision. This was not explained by lower resolution in peripheral vision. In addition, for male participants, it was more difficult to judge cuteness than beauty in peripheral vision, thus suggesting that gender differences can have a certain effect when judging cuteness. Therefore, central vision might be suitable for judging cuteness while judging beauty might not be affected by either central or peripheral vision. This might be related with the functional difference between beauty and cuteness.

  1. Changing perceptions of beauty: a surgeon's perspective.

    Science.gov (United States)

    Adamson, Peter A; Zavod, Matthew B

    2006-08-01

    Beauty is a mystery that has been with us for ages. Scholars and scientists have investigated its roots and effects, and its presence is ubiquitous. Has the construct of beauty changed over time? Is our sense of beauty learned or innate? What IS beauty, and can we quantify it? A substantial amount of work supports a Darwinian theory of selection, which predicts a survival advantage based on physical attractiveness. However, there is evidence that certain perceptions of beauty change with time. Indeed, the recent globalization of modern society has wrought changes in our perceptions of beauty. Are patients electing cosmetic surgery procuring a survival advantage, or are they bypassing genetics and setting a new standard for beauty? As facial plastic surgeons, we must be poised to respond to this metamorphosis and understand its roots. Although there is some equivocation and debate about this elusive subject, it is our duty to stay abreast of the current dynamic to make sound judgments that are in the best interests of our patients.

  2. Beauty and cuteness in peripheral vision

    Science.gov (United States)

    Kuraguchi, Kana; Ashida, Hiroshi

    2015-01-01

    Guo et al. (2011) showed that attractiveness was detectable in peripheral vision. Since there are different types of attractiveness (Rhodes, 2006), we investigated how beauty and cuteness are detected in peripheral vision with a brief presentation. Participants (n = 45) observed two Japanese female faces for 100 ms, then were asked to respond which face was more beautiful (or cuter). The results indicated that both beauty and cuteness were detectable in peripheral vision, but not in the same manner. Discrimination rates for judging beauty were invariant in peripheral and central vision, while discrimination rates for judging cuteness declined in peripheral vision as compared with central vision. This was not explained by lower resolution in peripheral vision. In addition, for male participants, it was more difficult to judge cuteness than beauty in peripheral vision, thus suggesting that gender differences can have a certain effect when judging cuteness. Therefore, central vision might be suitable for judging cuteness while judging beauty might not be affected by either central or peripheral vision. This might be related with the functional difference between beauty and cuteness. PMID:25999883

  3. Beauty and cuteness in peripheral vision.

    Science.gov (United States)

    Kuraguchi, Kana; Ashida, Hiroshi

    2015-01-01

    Guo et al. (2011) showed that attractiveness was detectable in peripheral vision. Since there are different types of attractiveness (Rhodes, 2006), we investigated how beauty and cuteness are detected in peripheral vision with a brief presentation. Participants (n = 45) observed two Japanese female faces for 100 ms, then were asked to respond which face was more beautiful (or cuter). The results indicated that both beauty and cuteness were detectable in peripheral vision, but not in the same manner. Discrimination rates for judging beauty were invariant in peripheral and central vision, while discrimination rates for judging cuteness declined in peripheral vision as compared with central vision. This was not explained by lower resolution in peripheral vision. In addition, for male participants, it was more difficult to judge cuteness than beauty in peripheral vision, thus suggesting that gender differences can have a certain effect when judging cuteness. Therefore, central vision might be suitable for judging cuteness while judging beauty might not be affected by either central or peripheral vision. This might be related with the functional difference between beauty and cuteness.

  4. Exhibition - Mathematics, A Beautiful Elsewhere

    CERN Multimedia

    2011-01-01

    From 21 October 2011 to 18 March 2012, the Fondation Cartier pour l’art contemporain will present the exhibition Mathematics: A Beautiful Elsewhere, an exhibition developed in association with the Institut des Hautes Études Scientifiques (IHÉS) and under the patronage of UNESCO. For this unprecedented event, the foundation invited mathematicians to work with artists with whom it has previously worked to create an exhibition that allows visitors to see, hear, do, interpret and think about mathematics. By bringing mathematics into its premises, the Fondation Cartier is itself undergoing the “sudden change of scenery” described by mathematician Alexandre Grothendieck. More information is available here. Fondation Cartier pour l’art contemporain 261, boulevard Raspail 75014 Paris http://fondation.cartier.com Private Visit For professors, researchers and all the staff of Mathematics departments...

  5. Bathing in Reeking Wounds: The Liberal Arts, Beauty, and War

    Science.gov (United States)

    Stimpson, Catharine R.

    2014-01-01

    A historic dialectic exists between the beautiful and the bestial. The bestial destroys the beautiful, but in a bloody miracle, the beautiful emerges from the womb of the bestial, the "terrible beauty" of which the poet W. B. Yeats wrote. The liberal arts, so often thought to dwell in a remote ivory tower, embody this dialectic. Wars and…

  6. Recognition and Description of Music and Beauty

    OpenAIRE

    矢向, 正人

    2011-01-01

    What is difficult with any discussion on music is that it cannot be objectively determined whether or not the music in question is a matter of beauty. On the other hand, we know that in the world there are some cultural areas where beauty is not known in connection with music. In this essay by introducing into play Wittgenstein's idea of "language game," the author proposes a theoretical model to recognize variouis kinds of musical beauty. According to the latter Wittgenstein, what is support...

  7. Pig transgenesis by Sleeping Beauty DNA transposition

    DEFF Research Database (Denmark)

    Jakobsen, Jannik E.; Li, Juan; Kragh, Peter M.

    2011-01-01

    disease models. In this report, we present transgenic pigs created by Sleeping Beauty DNA transposition in primary porcine fibroblasts in combination with somatic cell nuclear transfer by handmade cloning. Göttingen minipigs expressing green fluorescent protein are produced by transgenesis with DNA...... plasmid DNA. Our findings illustrate critical issues related to DNA transposon-directed transgenesis, including coincidental plasmid insertion and relatively low Sleeping Beauty transposition activity in porcine fibroblasts, but also provide a platform for future development of porcine disease models...... using the Sleeping Beauty gene insertion technology....

  8. Returns to beauty over the life course

    DEFF Research Database (Denmark)

    Jæger, Mads Meier

    This paper analyzes returns to facial beauty over the life course with respect to four outcomes: Socioeconomic status (SES), marital success, spouse’s SES, and health. I use data from the Wisconsin Longitudinal Study which, based on high school yearbook photos, has collected data on respondents......’ facial attractiveness as well as data on SES, marital, and health outcomes from their mid-20s to their mid-60s. I find that beauty has lasting positive returns for women since more beautiful women have higher SES throughout their working life, have a higher probability of being married at age 25...

  9. Angiogenesis in patients with psoriasis and psoriatic arthritis: cell-mediated and humoral mechanisms, its role in pathogenesis, and searching for promising therapeutic targets

    Directory of Open Access Journals (Sweden)

    T.V. Korotaeva

    2014-01-01

    Full Text Available Modern concepts of the role of angiogenesis in pathogenesis of psoriasis and psoriatic arthritis (PsA are analyzed. The features of cell-mediated and humoral immune responses resulting in proliferation of synovial membrane and vessel overgrowth in patients with this pathology are discussed. A number of angiogenesis mediators, pro-angiogenic cytokines, growth factors, matrix metalloproteinases, etc. are shown to be involved in progression of neovascularization. The role of tumor necrosis factor α as a key therapeutic target for treatment of psoriasis and PsA is emphasized. Drugs inhibiting some stages of angiogenesis, which are either used in clinical practice or are being developed, are discussed. 

  10. Is beauty skin deep – an approach to a beautiful face

    Directory of Open Access Journals (Sweden)

    Neerja Puri

    2014-07-01

    Full Text Available Everyone dreams of a beautiful and flawless face but true beauty is God given gift. Plastic surgery and various filler techniques can just highlight certain features and are just the temporary procedures. Features that further enhance the attractiveness of a beautiful face are the hair, skin, and teeth. These areas are the easiest to routinely enhance. There are many methods of facial sculpting including botulinum toxin, fillers and various other invasive plastic surgery techniques.

  11. Transcriptionally regulated and nontoxic delivery of the hyperactive Sleeping Beauty Transposase.

    Science.gov (United States)

    Cocchiarella, Fabienne; Latella, Maria Carmela; Basile, Valentina; Miselli, Francesca; Galla, Melanie; Imbriano, Carol; Recchia, Alessandra

    2016-01-01

    The Sleeping Beauty (SB) transposase and, in particular, its hyperactive variant SB100X raises increasing interest for gene therapy application, including genome modification and, more recently, induced pluripotent stem cells (iPS) reprogramming. The documented cytotoxicity of the transposase, when constitutively expressed by an integrating retroviral vector (iRV), has been circumvented by the transient delivery of SB100X using retroviral mRNA transfer. In this study, we developed an alternative, safe, and efficient transposase delivery system based on a tetracycline-ON regulated expression cassette and the rtTA2(S)-M2 transactivator gene transiently delivered by integration-defective lentiviral vectors (IDLVs). Compared with iRV-mediated delivery, expression of tetracycline-induced SB100X delivered by an IDLV results in more efficient integration of a GFP transposon and reduced toxicity. Tightly regulated expression and reactivation of the transposase was achieved in HeLa cells as wells as in human primary keratinocytes. Based on these properties, the regulated transposase-IDLV vectors may represent a valuable tool for genetic engineering and therapeutic gene transfer.

  12. The Relation between the ideal of beauty and dependent beauty in Kant's philosophy

    Directory of Open Access Journals (Sweden)

    Javad Amin

    2015-10-01

    Full Text Available Kant organizes his analysis in terms of four moments of the judgment of taste, each of which is supposed to contribute something essential to the complete exposition of the beautiful in "Critique of Judgment". He, in the third moment, based on the key concept analysis of "purposiveness", reaches to the beauty definition "a purposiveness without a purpose" (subjective purposiveness. Below this moment, two concepts of "dependent beauty" and "the ideal of beauty" also arises that aesthetic judgment in both of them is based on an objective purposiveness and a concept indicating nature of the object and the perfection of the object that is considered as default for judgment. This default in dependent beauty is perfection of the object and in the ideal of beauty is a concept from the sum of the rational idea and the aesthetic normal idea, but this point of view is in contradiction with the principle of Kant's aesthetic, which judgment of the beautiful just relies on the subjective purposiveness. This article reviewing the concept of purposiveness and the type of subjective purposiveness in the ideal of beauty and dependent beauty, attempts to explain the aesthetic value of these concepts and their differences and similarities, and finally to determine the position of these two concepts in Kant's philosophy.

  13. Ultrasound and Microbubble Mediated Doxil Delivery in a Murine Breast Cancer Model: Therapeutic Efficacy Dependence on Tumor Growth Rate

    NARCIS (Netherlands)

    Seip, R.; Leyvi, E.; Raju, B.I.; Shi, W.T.; Bohmer, M.R.; Chlon, C.H.T.; Sio, C.F.; Reibling, K.; Swanson, T.

    2011-01-01

    Background, Motivation and Objective: Localized drug delivery couldimprove the therapeutic efficacy for treatment of pathological lesions and reduce toxic exposure to healthy organs and tissues. The objective is to develop image-guided, ultrasound-activated tumor chemotherapy with intravenously admi

  14. Neuroaesthetics and the trouble with beauty.

    Directory of Open Access Journals (Sweden)

    Bevil R Conway

    Full Text Available Neuroscience is increasingly being called upon to address issues within the humanities. We discuss challenges that arise, relating to art and beauty, and provide ideas for a way forward.

  15. Interleukin-6, A Cytokine Critical to Mediation of Inflammation, Autoimmunity and Allograft Rejection: Therapeutic Implications of IL-6 Receptor Blockade.

    Science.gov (United States)

    Jordan, Stanley C; Choi, Jua; Kim, Irene; Wu, Gordon; Toyoda, Mieko; Shin, Bonga; Vo, Ashley

    2017-01-01

    The success of kidney transplants is limited by the lack of robust improvements in long-term survival. It is now recognized that alloimmune responses are responsible for the majority of allograft failures. Development of novel therapies to decrease allosensitization is critical. The lack of new drug development in kidney transplantation necessitated repurposing drugs initially developed in oncology and autoimmunity. Among these is tocilizumab (anti-IL-6 receptor [IL-6R]) which holds promise for modulating multiple immune pathways responsible for allograft injury and loss. Interleukin-6 is a cytokine critical to proinflammatory and immune regulatory cascades. Emerging data have identified important roles for IL-6 in innate immune responses and adaptive immunity. Excessive IL-6 production is associated with activation of T-helper 17 cell and inhibition of regulatory T cell with attendant inflammation. Plasmablast production of IL-6 is critical for initiation of T follicular helper cells and production of high-affinity IgG. Tocilizumab is the first-in-class drug developed to treat diseases mediated by IL-6. Data are emerging from animal and human studies indicating a critical role for IL-6 in mediation of cell-mediated rejection, antibody-mediated rejection, and chronic allograft vasculopathy. This suggests that anti-IL-6/IL-6R blockade could be effective in modifying T- and B-cell responses to allografts. Initial data from our group suggest anti-IL-6R therapy is of value in desensitization and prevention and treatment of antibody-mediated rejection. In addition, human trials have shown benefits in treatment of graft versus host disease in matched or mismatched stem cell transplants. Here, we explore the biology of IL-6/IL-6R interactions and the evidence for an important role of IL-6 in mediating allograft rejection.

  16. Charm, Beauty and Top at HERA

    CERN Document Server

    Behnke, O; Lisovyi, M

    2015-01-01

    Results on open charm and beauty production and on the search for top production in high-energy electron-proton collisions at HERA are reviewed. This includes a discussion of relevant theoretical aspects, a summary of the available measurements and measurement techniques, and their impact on improved understanding of QCD and its parameters, such as parton density functions and charm- and beauty-quark masses. The impact of these results on measurements at the LHC and elsewhere is also addressed.

  17. Charm, Beauty and Top at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Behnke, O.; Geiser, A.; Lisovyi, M.

    2015-06-15

    Results on open charm and beauty production and on the search for top production in high-energy electron-proton collisions at HERA are reviewed. This includes a discussion of relevant theoretical aspects, a summary of the available measurements and measurement techniques, and their impact on improved understanding of QCD and its parameters, such as parton density functions and charm- and beauty-quark masses. The impact of these results on measurements at the LHC and elsewhere is also addressed.

  18. Golden Ratio: A Measure of Physical Beauty

    Indian Academy of Sciences (India)

    2017-01-01

    Our attraction to another body increases if the body is symmetricaland in proportion. If a face or a structure is in proportion,we are more likely to notice it and find it beautiful.The universal ratio of beauty is the ‘Golden Ratio’, found inmany structures. This ratio comes from Fibonacci numbers.In this article, we explore this concept along with its applications.

  19. Therapeutic polypeptides based on HBV core 18-27 epitope can induce CD8+ CTL-mediated cytotoxicity in HLA-A2+ human PBMCs

    Institute of Scientific and Technical Information of China (English)

    Tong-Dong Shi; Yu-Zhang Wu; Zheng-Cai Jia; Li-Yun Zou; Wei Zhou

    2004-01-01

    AIM: To explore how to improve the immunogenicity of HBcAg CTL epitope based polypeptides and to trigger an HBV-specific HLA I-restricted CD8+ T cell response in vitro.METHODS: A new panel of mimetic therapeutic peptides based on the immunodominant B cell epitope of HBV PreS218-24 region, the CTL epitope of HBcAg18-27 and the universal T helper epitope of tetanus toxoid (TT) 830-843was designed using computerized molecular design method and synthesized by Merrifield's solid-phase peptide synthesis.Their immunological properties of stimulating activation and proliferation of lymphocytes, of inducing TH1 polarization,CD8+ T cell magnification and HBV-specific CD8+ CTL mediated cytotoxicity were investigatedin vitro using HLAA2+ human peripheral blood mononuclear cells (PBMCs) from healthy donors and chronic hepatitis B patients.RESULTS: Results demonstrated that the therapeutic polypeptides based on immunodominant HBcAg18-27 CTL,PreS2 B- and universal TH epitopes could stimulate the activation and proliferation of lymphocytes, induce specifically and effectively CD8+ T cell expansion and vigorous HBVspecific CTL-mediated cytotoxicity in human PBMCs.CONCLUSION: It indicated that the introduction of immunodominant T helper plus B-epitopes with short and flexible linkers could dramatically improve the immunogenicity of short CTL epitopes in vitro.

  20. Neutrophil-Mediated Delivery of Therapeutic Nanoparticles across Blood Vessel Barrier for Treatment of Inflammation and Infection.

    Science.gov (United States)

    Chu, Dafeng; Gao, Jin; Wang, Zhenjia

    2015-12-22

    Endothelial cells form a monolayer in lumen of blood vessels presenting a great barrier for delivery of therapeutic nanoparticles (NPs) into extravascular tissues where most diseases occur, such as inflammation disorders and infection. Here, we report a strategy for delivering therapeutic NPs across this blood vessel barrier by nanoparticle in situ hitchhiking activated neutrophils. Using intravital microscopy of TNF-α-induced inflammation of mouse cremaster venules and a mouse model of acute lung inflammation, we demonstrated that intravenously (iv) infused NPs made from denatured bovine serum albumin (BSA) were specifically internalized by activated neutrophils, and subsequently, the neutrophils containing NPs migrated across blood vessels into inflammatory tissues. When neutrophils were depleted using anti-Gr-1 in a mouse, the transport of albumin NPs across blood vessel walls was robustly abolished. Furthermore, it was found that albumin nanoparticle internalization did not affect neutrophil mobility and functions. Administration of drug-loaded albumin NPs markedly mitigated the lung inflammation induced by LPS (lipopolysaccharide) or infection by Pseudomonas aeruginosa. These results demonstrate the use of an albumin nanoparticle platform for in situ targeting of activated neutrophils for delivery of therapeutics across the blood vessel barriers into diseased sites. This study demonstrates our ability to hijack neutrophils to deliver nanoparticles to targeted diseased sites.

  1. The Ten Most Beautiful Experiments

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, George [The New York Times

    2010-10-20

    "Science in the 21st century has become industrialized. The experiments so often celebrated in the newspapers - sequencing the genome, proving the existence of the top quark, discovering a new planet by analyzing the wobble of a distant start - cost millions of dollars. They generate terabytes of data to be analyzed by supercomputers, calculating factories that spew out so much heat that they are equipped with cooling stacks and consume the energy of a small town. The experiments are carried out by research teams that have grown to the size of small corporations. But until very recently the most earth-shaking science came from individual pairs of hands. From a single mind confronting the unknown. The great experiments that mark the edges of our understanding were most often performed by one or two scientists and usually on a tabletop. Computation, if there was any, was carried out on paper or later with a slide rule. These experiments were designed and conducted with such straightforward elegance that they deserve to be called beautiful." (excerpt from the slide presentation accompanying the video)

  2. Materialised Ideals Sizes and Beauty

    Directory of Open Access Journals (Sweden)

    Kirsi Laitala

    2011-04-01

    Full Text Available Today’s clothing industry is based on a system where clothes are made in ready-to-wear sizes and meant to fit most people. Studies have pointed out that consumers are discontent with the use of these systems: size designations are not accurate enough to find clothing that fits, and different sizes are poorly available. This article discusses in depth who these consumers are, and which consumer groups are the most dissatisfied with today’s sizing systems. Results are based on a web survey where 2834 Nordic consumers responded, complemented with eight in-depth interviews, market analysis on clothing sizes and in-store trouser size measurements. Results indicate that higher shares of the consumers who have a body out of touch with the existing beauty ideals express discontentment with the sizing systems and the poor selection available. In particular, large women, very large men, and thin, short men are those who experience less priority in clothing stores and have more difficulties in finding clothes that fit. Consumers tend to blame themselves when the clothes do not fit their bodies, while our study points out that the industry is to blame as they do not produce clothing for all customers.

  3. Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity.

    Science.gov (United States)

    Izzo, Nicholas J; Xu, Jinbin; Zeng, Chenbo; Kirk, Molly J; Mozzoni, Kelsie; Silky, Colleen; Rehak, Courtney; Yurko, Raymond; Look, Gary; Rishton, Gilbert; Safferstein, Hank; Cruchaga, Carlos; Goate, Alison; Cahill, Michael A; Arancio, Ottavio; Mach, Robert H; Craven, Rolf; Head, Elizabeth; LeVine, Harry; Spires-Jones, Tara L; Catalano, Susan M

    2014-01-01

    Amyloid beta (Abeta) 1-42 oligomers accumulate in brains of patients with Mild Cognitive Impairment (MCI) and disrupt synaptic plasticity processes that underlie memory formation. Synaptic binding of Abeta oligomers to several putative receptor proteins is reported to inhibit long-term potentiation, affect membrane trafficking and induce reversible spine loss in neurons, leading to impaired cognitive performance and ultimately to anterograde amnesia in the early stages of Alzheimer's disease (AD). We have identified a receptor not previously associated with AD that mediates the binding of Abeta oligomers to neurons, and describe novel therapeutic antagonists of this receptor capable of blocking Abeta toxic effects on synapses in vitro and cognitive deficits in vivo. Knockdown of sigma-2/PGRMC1 (progesterone receptor membrane component 1) protein expression in vitro using siRNA results in a highly correlated reduction in binding of exogenous Abeta oligomers to neurons of more than 90%. Expression of sigma-2/PGRMC1 is upregulated in vitro by treatment with Abeta oligomers, and is dysregulated in Alzheimer's disease patients' brain compared to age-matched, normal individuals. Specific, high affinity small molecule receptor antagonists and antibodies raised against specific regions on this receptor can displace synthetic Abeta oligomer binding to synaptic puncta in vitro and displace endogenous human AD patient oligomers from brain tissue sections in a dose-dependent manner. These receptor antagonists prevent and reverse the effects of Abeta oligomers on membrane trafficking and synapse loss in vitro and cognitive deficits in AD mouse models. These findings suggest sigma-2/PGRMC1 receptors mediate saturable oligomer binding to synaptic puncta on neurons and that brain penetrant, small molecules can displace endogenous and synthetic oligomers and improve cognitive deficits in AD models. We propose that sigma-2/PGRMC1 is a key mediator of the pathological effects of

  4. Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity.

    Directory of Open Access Journals (Sweden)

    Nicholas J Izzo

    Full Text Available Amyloid beta (Abeta 1-42 oligomers accumulate in brains of patients with Mild Cognitive Impairment (MCI and disrupt synaptic plasticity processes that underlie memory formation. Synaptic binding of Abeta oligomers to several putative receptor proteins is reported to inhibit long-term potentiation, affect membrane trafficking and induce reversible spine loss in neurons, leading to impaired cognitive performance and ultimately to anterograde amnesia in the early stages of Alzheimer's disease (AD. We have identified a receptor not previously associated with AD that mediates the binding of Abeta oligomers to neurons, and describe novel therapeutic antagonists of this receptor capable of blocking Abeta toxic effects on synapses in vitro and cognitive deficits in vivo. Knockdown of sigma-2/PGRMC1 (progesterone receptor membrane component 1 protein expression in vitro using siRNA results in a highly correlated reduction in binding of exogenous Abeta oligomers to neurons of more than 90%. Expression of sigma-2/PGRMC1 is upregulated in vitro by treatment with Abeta oligomers, and is dysregulated in Alzheimer's disease patients' brain compared to age-matched, normal individuals. Specific, high affinity small molecule receptor antagonists and antibodies raised against specific regions on this receptor can displace synthetic Abeta oligomer binding to synaptic puncta in vitro and displace endogenous human AD patient oligomers from brain tissue sections in a dose-dependent manner. These receptor antagonists prevent and reverse the effects of Abeta oligomers on membrane trafficking and synapse loss in vitro and cognitive deficits in AD mouse models. These findings suggest sigma-2/PGRMC1 receptors mediate saturable oligomer binding to synaptic puncta on neurons and that brain penetrant, small molecules can displace endogenous and synthetic oligomers and improve cognitive deficits in AD models. We propose that sigma-2/PGRMC1 is a key mediator of the pathological

  5. RGD Peptide Cell-Surface Display Enhances the Targeting and Therapeutic Efficacy of Attenuated Salmonella-mediated Cancer Therapy.

    Science.gov (United States)

    Park, Seung-Hwan; Zheng, Jin Hai; Nguyen, Vu Hong; Jiang, Sheng-Nan; Kim, Dong-Yeon; Szardenings, Michael; Min, Jung Hyun; Hong, Yeongjin; Choy, Hyon E; Min, Jung-Joon

    2016-01-01

    Bacteria-based anticancer therapies aim to overcome the limitations of current cancer therapy by actively targeting and efficiently removing cancer. To achieve this goal, new approaches that target and maintain bacterial drugs at sufficient concentrations during the therapeutic window are essential. Here, we examined the tumor tropism of attenuated Salmonella typhimurium displaying the RGD peptide sequence (ACDCRGDCFCG) on the external loop of outer membrane protein A (OmpA). RGD-displaying Salmonella strongly bound to cancer cells overexpressing αvβ3, but weakly bound to αvβ3-negative cancer cells, suggesting the feasibility of displaying a preferential homing peptide on the bacterial surface. In vivo studies revealed that RGD-displaying Salmonellae showed strong targeting efficiency, resulting in the regression in αvβ3-overexpressing cancer xenografts, and prolonged survival of mouse models of human breast cancer (MDA-MB-231) and human melanoma (MDA-MB-435). Thus, surface engineering of Salmonellae to display RGD peptides increases both their targeting efficiency and therapeutic effect.

  6. Antimicrobial peptides: mediators of innate immunity as templates for the development of novel anti-infective and immune therapeutics.

    Science.gov (United States)

    Hiemstra, P S; Fernie-King, B A; McMichael, J; Lachmann, P J; Sallenave, J-M

    2004-01-01

    Antimicrobial molecules are ancient and essential small cationic molecules of the host defence system which are found in a wide variety of species. They display antimicrobial activity against a wide range of bacteria, fungi and viruses, an activity that has been mostly attributed to the disruption of microbial membranes. In this article, we will review the "classical" functions of 3 classes of antimicrobial molecules, namely defensins, cathelicidins, and the four-disulfide core proteins secretory leukocyte proteinase inhibitor (SLPI) and elafin. In addition to the study of their expression in a variety of cell types and the regulation of their production, we will also describe novel properties of these molecules that have been highlighted by recent studies. These include their ability to chemoattract a variety of inflammatory, immune and other cell types (neutrophils, macrophages, monocytes, lymphocytes, mast cells, epithelial cells) in vitro and in vivo. In addition, we will discuss the potential use of these newly discovered properties for therapeutic or vaccination purposes, using protein- or gene-transfer based methodologies. Finally, we will examine in an extensive fashion the strategies used by microorganisms to circumvent and subvert host defence mechanisms, such as the modifications of cell membranes and walls, the secretion of inactivating proteins and proteases and the down-regulation of expression of antimicrobial molecules. Increased understanding of the mechanisms used by both the host and the microbes to 'win the battle' may ultimately lead to new therapeutic strategies aimed to treat infectious diseases.

  7. Brain correlates of aesthetic judgment of beauty.

    Science.gov (United States)

    Jacobsen, Thomas; Schubotz, Ricarda I; Höfel, Lea; Cramon, D Yves V

    2006-01-01

    Functional MRI was used to investigate the neural correlates of aesthetic judgments of beauty of geometrical shapes. Participants performed evaluative aesthetic judgments (beautiful or not?) and descriptive symmetry judgments (symmetric or not?) on the same stimulus material. Symmetry was employed because aesthetic judgments are known to be often guided by criteria of symmetry. Novel, abstract graphic patterns were presented to minimize influences of attitudes or memory-related processes and to test effects of stimulus symmetry and complexity. Behavioral results confirmed the influence of stimulus symmetry and complexity on aesthetic judgments. Direct contrasts showed specific activations for aesthetic judgments in the frontomedian cortex (BA 9/10), bilateral prefrontal BA 45/47, and posterior cingulate, left temporal pole, and the temporoparietal junction. In contrast, symmetry judgments elicited specific activations in parietal and premotor areas subserving spatial processing. Interestingly, beautiful judgments enhanced BOLD signals not only in the frontomedian cortex, but also in the left intraparietal sulcus of the symmetry network. Moreover, stimulus complexity caused differential effects for each of the two judgment types. Findings indicate aesthetic judgments of beauty to rely on a network partially overlapping with that underlying evaluative judgments on social and moral cues and substantiate the significance of symmetry and complexity for our judgment of beauty.

  8. CD40-mediated NFκB activation in B cells is increased in multiple sclerosis and modulated by therapeutics1

    Science.gov (United States)

    Chen, Ding; Ireland, Sara J.; Remington, Gina; Alvarez, Enrique; Racke, Michael K.; Greenberg, Benjamin; Frohman, Elliot M.; Monson, Nancy L.

    2017-01-01

    CD40 interacts with CD40 ligand and plays an essential role in immune regulation and homeostasis. Recent research findings, however, support a pathogenic role of CD40 in a number of autoimmune diseases. We previously showed that memory B cells from relapsing-remitting multiple sclerosis (RRMS) patients exhibited enhanced proliferation with CD40 stimulation compared to healthy donors. In this study, we used a multi-parameter phosflow approach to analyze the phosphorylation status of NFκB and three major MAP kinases (P38, ERK and JNK), the essential components of signaling pathways downstream of CD40 engagement in B cells from MS patients. We found that memory and naïve B cells from RRMS and secondary progressive MS (SPMS) patients exhibited a significantly elevated level of phosphorylated NFκB (p-P65) following CD40 stimulation compared to healthy donor controls. Combination therapy with interferon beta-1a (Avonex) and mycophenolate mofetil (Cellcept) modulated the hyper-phosphorylation of P65 in B cells of RRMS patients at levels similar to healthy donor controls. Lower disease activity after the combination therapy correlated with the reduced phosphorylation of P65 following CD40 stimulation in treated patients. In addition, glatiramer acetate (GA) treatment also significantly reduced CD40-mediated P65 phosphorylation in RRMS patients, suggesting that reducing CD40-mediated p-P65 induction may be a general mechanism by which some current therapies modulate MS disease. PMID:27798157

  9. Death, beauty, and iconoclastic nostalgia

    DEFF Research Database (Denmark)

    Fetveit, Arild

    2015-01-01

    developments have responded with a series of productive interventions. Drawing on many of these, I propose a media aesthetic approach where the disruptions in question are conceived as involving instances of precarious mediation to be examined within a precarious aesthetics. The music videos of Lana Del Rey......, cinematographers, Do-It-Yourself enthusiasts, Polaroid fans, Instagram users, music video directors and others. Since the mid 1990s, a partially iconoclastic impulse set on exploring the mortality of media materials has often taken the form of medium-specific noise. In recent years, however, alternative strategies...... effectively articulate ways in which precarious mediation is used in contemporary popular culture. In many of her music videos, like in the videos for Summertime Sadness (2012) and Summer Wine (2013), the precarious mediation is given a nostalgic inflection, where an ambiguous yearning for the past...

  10. The evolutionary psychology of facial beauty.

    Science.gov (United States)

    Rhodes, Gillian

    2006-01-01

    What makes a face attractive and why do we have the preferences we do? Emergence of preferences early in development and cross-cultural agreement on attractiveness challenge a long-held view that our preferences reflect arbitrary standards of beauty set by cultures. Averageness, symmetry, and sexual dimorphism are good candidates for biologically based standards of beauty. A critical review and meta-analyses indicate that all three are attractive in both male and female faces and across cultures. Theorists have proposed that face preferences may be adaptations for mate choice because attractive traits signal important aspects of mate quality, such as health. Others have argued that they may simply be by-products of the way brains process information. Although often presented as alternatives, I argue that both kinds of selection pressures may have shaped our perceptions of facial beauty.

  11. Combining universal beauty and cultural context in a unifying model of visual aesthetic experience

    Directory of Open Access Journals (Sweden)

    Christoph eRedies

    2015-04-01

    Full Text Available In this work, I propose a model of visual aesthetic experience that combines formalist and contextual aspects of aesthetics. The model distinguishes between two modes of processing. First, perceptual processing is based on the intrinsic form of an artwork, which may or may not be beautiful. If it is beautiful, a beauty-responsive mechanism is activated in the brain. This bottom-up mechanism is universal amongst humans; it is widespread in the visual brain and responsive across visual modalities. Second, cognitive processing is based on contextual information, such as the depicted content, the intentions of the artist or the circumstances of the presentation of the artwork. Cognitive processing is partially top-down and varies between individuals according to their cultural experience. Processing in the two channels is parallel and largely independent. In the general case, an aesthetic experience is induced if processing in both channels is favorable, i.e., if there is resonance in the perceptual processing channel (aesthetics of perception, and successful mastering in the cognitive processing channel (aesthetics of cognition. I speculate that this combinatorial mechanism has evolved to mediate social bonding between members of a (cultural group of people. Primary emotions can be elicited via both channels and modulate the degree of the aesthetic experience. Two special cases are discussed. First, in a subset of (post-modern art, beauty no longer plays a prominent role. Second, in some forms of abstract art, beautiful form can be enjoyed with minimal cognitive processing. The model is applied to examples of Western art. Finally, implications of the model are discussed.In summary, the proposed model resolves the seeming contradiction between formalist perceptual approaches to aesthetic experience, which are based on the intrinsic beauty of artworks, and contextual approaches, which account for highly individual and culturally dependent aspects of

  12. Combining universal beauty and cultural context in a unifying model of visual aesthetic experience.

    Science.gov (United States)

    Redies, Christoph

    2015-01-01

    In this work, I propose a model of visual aesthetic experience that combines formalist and contextual aspects of aesthetics. The model distinguishes between two modes of processing. First, perceptual processing is based on the intrinsic form of an artwork, which may or may not be beautiful. If it is beautiful, a beauty-responsive mechanism is activated in the brain. This bottom-up mechanism is universal amongst humans; it is widespread in the visual brain and responsive across visual modalities. Second, cognitive processing is based on contextual information, such as the depicted content, the intentions of the artist or the circumstances of the presentation of the artwork. Cognitive processing is partially top-down and varies between individuals according to their cultural experience. Processing in the two channels is parallel and largely independent. In the general case, an aesthetic experience is induced if processing in both channels is favorable, i.e., if there is resonance in the perceptual processing channel ("aesthetics of perception"), and successful mastering in the cognitive processing channel ("aesthetics of cognition"). I speculate that this combinatorial mechanism has evolved to mediate social bonding between members of a (cultural) group of people. Primary emotions can be elicited via both channels and modulate the degree of the aesthetic experience. Two special cases are discussed. First, in a subset of (post-)modern art, beauty no longer plays a prominent role. Second, in some forms of abstract art, beautiful form can be enjoyed with minimal cognitive processing. The model is applied to examples of Western art. Finally, implications of the model are discussed. In summary, the proposed model resolves the seeming contradiction between formalist perceptual approaches to aesthetic experience, which are based on the intrinsic beauty of artworks, and contextual approaches, which account for highly individual and culturally dependent aspects of aesthetics.

  13. TV Beauty Ads and Role Expectations of Adolescent Female Viewers.

    Science.gov (United States)

    Tan, Alexis S.

    1979-01-01

    A study of the responses of 56 high school girls shows the cultivation effects of television beauty-related commercials on the girls' perceptions of the importance of sex appeal, youth, and beauty to women in four different roles. (GT)

  14. Antitumor activity and prolonged survival by carbon-nanotube-mediated therapeutic siRNA silencing in a human lung xenograft model.

    Science.gov (United States)

    Podesta, Jennifer E; Al-Jamal, Khuloud T; Herrero, M Antonia; Tian, Bowen; Ali-Boucetta, Hanene; Hegde, Vikas; Bianco, Alberto; Prato, Maurizio; Kostarelos, Kostas

    2009-05-01

    Carbon nanotubes are novel nanomaterials that are thought to offer potential benefits to a variety of biomedical and clinical applications. In this study, the treatment of a human lung carcinoma model in vivo using siRNA sequences leading to cytotoxicity and cell death is carried out using either cationic liposomes (DOTAP:cholesterol) or amino-functionalized multi-walled carbon nanotubes (MWNT - NH(+)(3)). Validation for the most cytotoxic siRNA sequence using a panel of human carcinoma and murine cells reveals that the proprietary siTOX sequence is human specific and can lead to significant cytotoxic activities delivered both by liposome or MWNT - NH(+)(3) in vitro. A comparative study using both types of vector indicates that only MWNT - NH(+)(3):siRNA complexes administered intratumorally can elicit delayed tumor growth and increased survival of xenograft-bearing animals. siTOX delivery via the cationic MWNT - NH(+)(3) is biologically active in vivo by triggering an apoptotic cascade, leading to extensive necrosis of the human tumor mass. This suggests that carbon-nanotube-mediated delivery of siRNA by intratumoral administration leads to successful and statistically significant suppression of tumor volume, followed by a concomitant prolongation of survival of human lung tumor-bearing animals. The direct comparison between carbon nanotubes and liposomes demonstrates the potential advantages offered by carbon nanotubes for the intracellular delivery of therapeutic agents in vivo. The present work may act as the impetus for further studies to explore the therapeutic capacity of chemically functionalized carbon nanotubes to deliver siRNA directly into the cytoplasm of target cells and achieve effective therapeutic silencing in various disease indications where local delivery is feasible or desirable.

  15. The Beautiful and Beauty in St. Thomas’ Commentary to De Divinis Nominibus

    Directory of Open Access Journals (Sweden)

    Hugo Costarelli Brandi

    2016-09-01

    Full Text Available The article is written in Spanish. While St. Thomas Aquinas has not written any separate treaty on beauty, the theme of beauty regularly appears in his writing from its very beginning as that which corresponds with the Platonic doctrine presented by Dionysius the Areopagite in his De Divinis Nominibus. The article is focused on three essential elements in Aquinas’ doctrine on beauty: 1 its identity with the subject, 2 its difference from the reason, and 3 its difference from the good.

  16. Beautiful skin%美丽肌肤

    Institute of Scientific and Technical Information of China (English)

    胡敏

    2012-01-01

    介绍了皮肤皱纹生成的机理,抗皱有效成分、作用机理以及皮肤的抗衰老护理。介绍了一些美容食品、抗老化美容成分以及最具潜力的原料来源。%The mechanism of skin wrinkle formation,the active ingredients of anti-aging,the mechanism of action as well as skin anti-aging care were introduced here.Some beautiful foods,anti-aging beautiful ingredients and the most interesting source of feed were also related.

  17. On the Beauty in Keats’s Ode to Autumn

    Institute of Scientific and Technical Information of China (English)

    谭凯

    2011-01-01

    Keats’s poems are famous for beauty,and Ode to Autumn is generally regarded as one of his most beautiful poems.In this ode,Keats presents a vivid picture of the harvesting autumn,in which many forms of beauty can be captured.The present paper attempts to conduct an analysis of the beauty in Keats’s Ode to Autumn,hopefully it could help readers better understand Keats and his works.

  18. Combined 2-deoxy glucose and metformin improves therapeutic efficacy of sodium-iodide symporter-mediated targeted radioiodine therapy in breast cancer cells

    Directory of Open Access Journals (Sweden)

    Chatterjee S

    2015-08-01

    Full Text Available Sushmita Chatterjee, Nirmal Thaker, Abhijit DeMolecular Functional Imaging Laboratory, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai, IndiaAbstract: Radiosensitization using either metformin or 2-deoxy-d-glucose (2-DG in various cancer cells has been reported. The present study reveals novel information on combining these drugs to enhance radiosensitization effect in breast cancer (BC cells. Responses to low-dose Cobalt60 radiation, as well as a newly emerged radioiodine therapy target for BC, that is, sodium-iodide symporter (NIS or SLC5A5 protein, are tested. As therapeutic potential of NIS in BC is often limited due to low uptake and fast efflux rate of iodine, the scope of these two radiosensitizers to further improve NIS-mediated 131I therapeutic efficacy is explored. Two BC cell lines, MCF-7, and MDA MB231 are tested to optimize minimal drug doses required for radiosensitization. A combination of 2 mM metformin and 20 mM 2-DG with 2 grey (Gy Cobalt60 radiation shows significant radiosensitization effect (P=0.0002. In cells treated with the combination therapy, increased γH2A.X foci formation was noted. Further, MCF-7 BC cells overexpressing NIS (MCF-7 NIS was established, and using the optimized drug concentrations, significant radiosensitization (P=0.0019 by 50 µ Ci 131I usage was found to be the case as well. Apoptosis data corroborates with the result of clonogenic assay showing significant increase in apoptotic population upon dual drug-mediated radiosensitization. In case of metformin treatment, lowered adenosine triphosphate (ATP content of the cell has been observed. The encouraging radiosensitization effect observed using combined 2-DG and metformin may aid in reducing Cobalt60 radiation exposure or for targeted radioiodine therapy in BC cells with NIS expression. This study indicates high potential of this drug combination in sensitizing BC cells for NIS-mediated

  19. 75 FR 21595 - Beauty and Cosmetics Trade Mission to India

    Science.gov (United States)

    2010-04-26

    ... International Trade Administration Beauty and Cosmetics Trade Mission to India AGENCY: International Trade... Beauty and Cosmetics Trade Mission to India (New Delhi, Mumbai and Bangalore), November 15-19, 2010. Led... Indian market. The cosmetics/ beauty industry is one of the booming retail sectors in India with...

  20. 75 FR 33763 - Beauty and Cosmetics Trade Mission to India

    Science.gov (United States)

    2010-06-15

    ... International Trade Administration Beauty and Cosmetics Trade Mission to India AGENCY: International Trade... Beauty and Cosmetics Trade Mission to India (New Delhi, Mumbai and Bangalore), November 15-19, 2010. Led.... The cosmetics/beauty industry is one of the booming retail sectors in India with very strong...

  1. Walking in Beauty: An American Indian Perspective on Social Justice

    Science.gov (United States)

    Eason, Evan Allen; Robbins, Rockey

    2012-01-01

    The purpose of this article is to introduce "walking in beauty," an American Indian spiritual perspective related to social justice that emphasizes beauty, harmony, connectedness/unity of experience, and imagination. Walking in beauty includes 3 processes: embodiment, creativity, and appreciation of the sublime. Recommendations are offered for…

  2. Perception of the beauty and body image in Czech Republic, Slovakia and Hungary with application on beauty industry

    OpenAIRE

    Chotváč, Richard

    2012-01-01

    ABSTRACT CHOTVÁČ, Richard: Perception of beauty and body image in Czech Republic, Slovakia and Hungary and its application in beauty industry. [Master thesis] -- University of Economics in Prague, VŠE. Faculty of Business Administration; Tutor: doc. Ing. Jan Koudelka, CSc. Prague: VŠE, 2013, 82pages. The Master thesis deals with the perception of the beauty in 3 countries, Czech Republic, Slovakia and Hungary. This thesis is showing differences between the perception of body image and beauty ...

  3. Poplus Diversifolia:The Most Beautiful Tree

    Institute of Scientific and Technical Information of China (English)

    ZhanHua

    2004-01-01

    Populus diversifolia,an old and rare tree species,is an only tree variety that can naturally grow into forest in Xinjiang's deserts.It is called "Tokolako"in the Uigur language,meaning"the most beautiful tree".Its extraordinary resistance to drought,sand wind and sanitization enables it to thrive in deserts and gains it repute

  4. Why Beautiful People Are More Intelligent

    Science.gov (United States)

    Kanazawa, Satoshi; Kovar, Jody L.

    2004-01-01

    Empirical studies demonstrate that individuals perceive physically attractive others to be more intelligent than physically unattractive others. While most researchers dismiss this perception as a ''bias'' or ''stereotype,'' we contend that individuals have this perception because beautiful people indeed "are" more intelligent. The conclusion that…

  5. Beauty baryon decays: a theoretical overview

    Science.gov (United States)

    Wang, Yu-Ming

    2014-11-01

    I overview the theoretical status and recent progress on the calculations of beauty baryon decays focusing on the QCD aspects of the exclusive semi-leptonic Λb → plμ decay at large recoil and theoretical challenges of radiative and electro-weak penguin decays Λb → Λγ,Λl+l-.

  6. Open Charm and Beauty Production at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Behnke, Olaf [DESY, Notkestrasse 85, 22607 Hamburg (Germany)

    2012-01-15

    A review is provided of open charm and beauty production at HERA and its description by perturbative QCD (pQCD). Four years after the end of the data taking there is still a steady flow of new charm and beauty results from HERA. Among the results reported here are the first combined H1 and ZEUS measurements on the contribution from charm production to deep inelastic scattering (DIS), represented by the structure function F{sub 2}{sup cc{sup {sup M{sup a{sup c{sup r{sup o{sup n{sup }}}}}}}}}, as well as new precise results on the corresponding structure function for beauty production, F{sub 2}{sup bb{sup {sup M{sup a{sup c{sup r{sup o{sup n{sup }}}}}}}}}. Furthermore the situation of charm and beauty production in the photoproduction kinematic regime is reviewed. Since it is a related field also the first hadroproduction results from LHC are presented. A brief outlook is given on open heavy flavour prospects at possible future ep colliders, with a focus on the LHeC.

  7. Beauty as Fit: A Metaphor in Mathematics?

    Science.gov (United States)

    Raman, Manya; Öhman, Lars-Daniel

    2013-01-01

    Beauty, which plays a central role in the practice of mathematics (Sinclair 2002), is almost absent in discussions of school mathematics (Dreyfus and Eisenberg 1986). This is problematic, because students will decide whether or not to continue their studies in mathematics without having an accurate picture of what the subject is about. In order to…

  8. Beauty, a road to the truth

    NARCIS (Netherlands)

    Kuipers, T.A.F.

    2002-01-01

    In this article I give a naturalistic-cum-formal analysis of the relation between beauty, empirical success, and truth. The analysis is based on the one hand on a hypothetical variant of the so-called 'mere-exposure effect' which has been more or less established in experimental psychology regarding

  9. The Beauty of Painting in English Writing

    Institute of Scientific and Technical Information of China (English)

    郝艳慧

    2016-01-01

    English writing ability is emphasized in English teaching without any doubt. And this article attempts to reexamine the teaching of writing and explain the nature of writing from an aesthetic perspective-its beauty of painting. Hope either teachers or students could make a deep aesthetic understanding of English writing from this article.

  10. Miss International Beauty Pageant in China

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ The 47th Miss International Beauty Pageant, jointly sponsored by China Youth Concern Committee for the Advancement of Health and Physical Culture Development, International Culture Association, Kessles Paris, International Culture Exchange Organization,and co-organized by Beijing Kessles International Culture Media Co., Ltd., will be held in Beijing, China, according to the press conference on March 21.

  11. The Beautiful Physics of LHC Run 2

    CERN Document Server

    AUTHOR|(CDS)2108556

    2015-01-01

    Run 2 of the LHC offers some beautiful prospects for new physics, including flavour physics as well as more detailed studies of the Higgs boson and searches for new physics beyond the Standard Model (BSM). One of the possibilities for BSM physics is supersymmetry, and flavour physics plays various important r\\^oles in constraining supersymmetric models.

  12. Is moral beauty different from facial beauty? Evidence from an fMRI study

    OpenAIRE

    Wang, Tingting; Mo, Lei; Mo, Ce; Tan, Li Hai; Cant, Jonathan S.; Zhong, Luojin; Cupchik, Gerald

    2014-01-01

    Is moral beauty different from facial beauty? Two functional magnetic resonance imaging experiments were performed to answer this question. Experiment 1 investigated the network of moral aesthetic judgments and facial aesthetic judgments. Participants performed aesthetic judgments and gender judgments on both faces and scenes containing moral acts. The conjunction analysis of the contrasts ‘facial aesthetic judgment > facial gender judgment’ and ‘scene moral aesthetic judgment > scene gender ...

  13. Beauty and Brains: Detecting Anomalous Pattern Co-Occurrences

    OpenAIRE

    Bertens, Roel; Vreeken, Jilles; Siebes, Arno

    2015-01-01

    Our world is filled with both beautiful and brainy people, but how often does a Nobel Prize winner also wins a beauty pageant? Let us assume that someone who is both very beautiful and very smart is more rare than what we would expect from the combination of the number of beautiful and brainy people. Of course there will still always be some individuals that defy this stereotype; these beautiful brainy people are exactly the class of anomaly we focus on in this paper. They do not posses intri...

  14. Natural Tendency towards Beauty in Humans: Evidence from Binocular Rivalry.

    Directory of Open Access Journals (Sweden)

    Ce Mo

    Full Text Available Although human preference for beauty is common and compelling in daily life, it remains unknown whether such preference is essentially subserved by social cognitive demands or natural tendency towards beauty encoded in the human mind intrinsically. Here we demonstrate experimentally that humans automatically exhibit preference for visual and moral beauty without explicit cognitive efforts. Using a binocular rivalry paradigm, we identified enhanced gender-independent perceptual dominance for physically attractive persons, and the results suggested universal preference for visual beauty based on perceivable forms. Moreover, we also identified perceptual dominance enhancement for characters associated with virtuous descriptions after controlling for facial attractiveness and vigilance-related attention effects, which suggested a similar implicit preference for moral beauty conveyed in prosocial behaviours. Our findings show that behavioural preference for beauty is driven by an inherent natural tendency towards beauty in humans rather than explicit social cognitive processes.

  15. Natural Tendency towards Beauty in Humans: Evidence from Binocular Rivalry.

    Science.gov (United States)

    Mo, Ce; Xia, Tiansheng; Qin, Kaixin; Mo, Lei

    2016-01-01

    Although human preference for beauty is common and compelling in daily life, it remains unknown whether such preference is essentially subserved by social cognitive demands or natural tendency towards beauty encoded in the human mind intrinsically. Here we demonstrate experimentally that humans automatically exhibit preference for visual and moral beauty without explicit cognitive efforts. Using a binocular rivalry paradigm, we identified enhanced gender-independent perceptual dominance for physically attractive persons, and the results suggested universal preference for visual beauty based on perceivable forms. Moreover, we also identified perceptual dominance enhancement for characters associated with virtuous descriptions after controlling for facial attractiveness and vigilance-related attention effects, which suggested a similar implicit preference for moral beauty conveyed in prosocial behaviours. Our findings show that behavioural preference for beauty is driven by an inherent natural tendency towards beauty in humans rather than explicit social cognitive processes.

  16. Examination of nanoformulated crosslinked polymers complexed with copper/zinc superoxide dismutase as a therapeutic strategy for angiotensin II-mediated hypertension

    Science.gov (United States)

    Savalia, Krupa

    Excessive generation of superoxide (O2·-) has been extensively implicated as a signaling molecule in cardiovascular pathologies, including hypertension. As a major risk factor for myocardial infarction, stroke, and heart failure, the morbidity and mortality associated with hypertension is a worldwide epidemic. Although there are several standard therapies that effectively lower blood pressure, many hypertensive patients have uncontrolled blood pressure despite taking available medications. Thus, there is a necessity to develop new pharmacotherapies that target novel molecular effectors (e.g. O2·-) that have been implicated to be integral in the pathogenesis of hypertension. To overcome the failed therapeutic impact of currently available antioxidants in cardiovascular disease, we developed a nanomedicine-based delivery system for the O2 ·- scavenging enzyme, copper/zinc superoxide dismutase (CuZnSOD), in which CuZnSOD protein is electrostatically bound to poly-L-lysine (PLL 50)-polyethylene glycol (PEG) block co-polymer to form CuZnSOD nanozyme. Different formulations of CuZnSOD nanozyme are covalently stabilized by either reducible or non-reducible crosslinked bonds between the PLL50-PEG polymers. Herein, we tested the overall hypothesis that PLL50-PEG CuZnSOD nanozyme delivers active CuZnSOD protein to neurons and decreases blood pressure in a model of Angll-dependent hypertension. As determined by electron paramagnetic resonance (EPR) spectroscopy, nanozymes retain full SOD enzymatic activity. Furthermore, non-reducible crosslinked nanozyme delivers active CuZnSOD protein to central neurons in culture (CATH.a neurons) without inducing significant neuronal toxicity. In vivo studies conducted in Angll-mediated hypertensive adult male C57BL/6 mice demonstrate that the non-reducible crosslinked nanozyme significantly attenuates blood pressure when given directly into the brain and prevents the further increase in hypertension when intravenously (IV) administered

  17. El ojo hermoso The beautiful eye

    Directory of Open Access Journals (Sweden)

    O. M. Ramírez

    2007-06-01

    Full Text Available Como cirujanos estéticos siempre nos esforzamos por alcanzar resultados hermosos que sean agradables a los sentidos. Esto es particularmente cierto en el terreno del rejuvenecimiento periorbitario. Según la estadística de la Sociedad Americana de Cirujanos Plásticos la blefaroplastia estética es uno de los procedimientos mas frecuentes y su frecuencia va en aumento tanto en hombres como en mujeres. El rejuvenecimiento periorbitario adecuado debería restaurar la percepción interior del paciente respecto a belleza y juventud de sus ojos, así como proporcionar un aspecto externo que sea "estético" o agradable a los sentidos. Para lograr este objetivo, se requiere una comprensión de la estética facial, tanto en términos subjetivos como objetivos. Los investigadores han demostrado que la percepción del atractivo o la belleza en la cara de un individuo es relativamente constante entre observadores independientes, desafiando el dicho popular de que "la belleza está en el ojo del espectador." Presentamos una actualización del tema y una amplia iconografía. La información recogida de la literatura y de años experiencia clínica debería permitir al lector desarrollar una mayor sensibilidad estética, para obtener resultados óptimos en el rejuvenecimiento periorbitario.As aesthetic surgeons we are always striving to achieve beautiful results that are pleasurable to the senses. This is particularly certain in the land of the periorbital rejuvenation. According to the statistics of the American Society of Plastic Surgeons, aesthetic blepharoplasty is one of the procedures most commonly performed and goes in increase its so much frequency in men as in women. Successful periorbital rejuvenation should restore the patient"s inner sense of beauty and youthfulness as well as provide an outward appearance that is ‘aesthetic" or pleasurable to the senses. To accomplish this lofty goal, the aesthetic surgeon must strive to create "the beautiful

  18. Collapsin Response Mediator Protein-2 (CRMP2) is a Plausible Etiological Factor and Potential Therapeutic Target in Alzheimer's Disease: Comparison and Contrast with Microtubule-Associated Protein Tau.

    Science.gov (United States)

    Hensley, Kenneth; Kursula, Petri

    2016-04-15

    Alzheimer's disease (AD) has long been viewed as a pathology that must be caused either by aberrant amyloid-β protein precursor (AβPP) processing, dysfunctional tau protein processing, or a combination of these two factors. This is a reasonable assumption because amyloid-β peptide (Aβ) accumulation and tau hyperphosphorylation are the defining histological features in AD, and because AβPP and tau mutations can cause AD in humans or AD-like features in animal models. Nonetheless, other protein players are emerging that one can argue are significant etiological players in subsets of AD and potentially novel, druggable targets. In particular, the microtubule-associated protein CRMP2 (collapsin response mediator protein-2) bears striking analogies to tau and is similarly relevant to AD. Like tau, CRMP2 dynamically regulates microtubule stability; it is acted upon by the same kinases; collects similarly in neurofibrillary tangles (NFTs); and when sequestered in NFTs, complexes with critical synapse-stabilizing factors. Additionally, CRMP2 is becoming recognized as an important adaptor protein involved in vesicle trafficking, amyloidogenesis and autophagy, in ways that tau is not. This review systematically compares the biology of CRMP2 to that of tau in the context of AD and explores the hypothesis that CRMP2 is an etiologically significant protein in AD and participates in pathways that can be rationally engaged for therapeutic benefit.

  19. The therapeutic response of CDDO-Me in the esophageal squamous cell carcinoma (ESCC) cells is mediated by CaMKIIα.

    Science.gov (United States)

    Wang, Yan-Yang; Zhou, Shun; Zhao, Ren; Hai, Ping; Zhe, Hong

    2016-01-01

    CDDO-Me has exhibited a potent anticancer effect in human esophageal squamous cell carcinoma (ESCC) cells in our previous study, but the molecular interactome remains elusive. We applied the approach of stable-isotope labeling by amino acids in cell culture (SILAC) to assess the proteomic responses of CDDO-Me treatment in human ESCC Ec109 cells. The data were subsequently validated using Western blot assay. The results of our study revealed that CDDO-Me increased the expression level of 543 protein molecules, but decreased the expression level of 709 protein molecules in Ec109 cells. Among these modulated protein molecules, calcium/calmodulin-dependent protein kinase type II subunit α (CaMKIIα) was highly expressed in all tested ESCC cell lines, whereas its expression levels were substantially lower in normal control cell line. Its silencing by small interfering RNA inhibited CDDO-Me induced apoptosis and autophagy in ESCC cells. Collectively, these data demonstrate that the therapeutic response of CDDO-Me in the human ESCC cells is mediated by CaMKIIα.

  20. Defining Therapeutic Targets by Using Adenovirus: Blocking NF-kappa B Inhibits Both Inflammatory and Destructive Mechanisms in Rheumatoid Synovium but Spares Anti-Inflammatory Mediators

    Science.gov (United States)

    Bondeson, Jan; Foxwell, Brian; Brennan, Fionula; Feldmann, Marc

    1999-05-01

    The role of the transcription factor NF-kappa B in the pathogenesis of rheumatoid arthritis has long been a subject of controversy. We used an adenoviral technique of blocking NF-kappa B through overexpression of the inhibitory subunit Ikappa Bα , which has the advantage that it can be used in the diseased tissue itself, with >90% of the synovial macrophages, fibroblasts, and T cells infected. We found that the spontaneous production of tumor necrosis factor α and other pro-inflammatory cytokines is NF-kappa B-dependent in rheumatoid synovial tissue, in contrast to the main anti-inflammatory mediators, like IL-10 and -11, and the IL-1 receptor antagonist. Of even more interest, Ikappa Bα overexpression inhibited the production of matrix metalloproteinases 1 and 3 while not affecting their tissue inhibitor. Blocking NF-kappa B in the rheumatoid joint thus has a very beneficial profile, reducing both the inflammatory response and the tissue destruction. The adenoviral technique described here has widespread applicability, allowing rapid testing of the effects of blocking a potential therapeutic target in either cultures of normal cells or in the diseased tissue itself.

  1. Trypanosoma cruzi-elicited CD8+ T cell-mediated myocarditis: chemokine receptors and adhesion molecules as potential therapeutic targets to control chronic inflammation?

    Directory of Open Access Journals (Sweden)

    Joseli Lannes-Vieira

    2003-04-01

    Full Text Available In Chagas disease, during the acute phase, the establishment of inflammatory processes is crucial for Trypanosoma cruzi control in target tissues and for the establishment of host/parasite equilibrium. However, in about 30% of the patients, inflammation becomes progressive, resulting in chronic disease, mainly characterized by myocarditis. Although several hypothesis have been raised to explain the pathogenesis of chagasic myocardiopathy, including the persistence of the parasite and/or participation of autoimmune processes, the molecular mechanisms underlying the establishment of the inflammatory process leading to parasitism control but also contributing to the maintenance of T. cruzi-elicited chronic myocarditis remain unsolved. Trying to shed light on these questions, we have for several years been working with murine models for Chagas disease that reproduce the acute self-resolving meningoencephalitis, the encephalitis resulting of reactivation described in immunodeficient individuals, and several aspects of the acute and chronic myocarditis. In the present review, our results are summarized and discussed under the light of the current literature. Furthermore, rational therapeutic intervention strategies based on integrin-mediated adhesion and chemokine receptor-driven recruitment of leukocytes are proposed to control T. cruzi-elicited unbalanced inflammation.

  2. Sleeping Beauty transposon system for genetic etiological research and gene therapy of cancers.

    Science.gov (United States)

    Hou, Xiaomei; Du, Yan; Deng, Yang; Wu, Jianfeng; Cao, Guangwen

    2015-01-01

    Carcinogenesis is etiologically associated with somatic mutations of critical genes. Recently, a number of somatic mutations and key molecules have been found to be involved in functional networks affecting cancer progression. Suitable animal models are required to validate cancer-promoting or -inhibiting capacities of these mutants and molecules. Sleeping Beauty transposon system consists of a transposon that carries gene(s) of interest and a transposase that recognizes, excises, and reinserts genes in given location of the genome. It can create both gain-of-function and loss-of-function mutations, thus being frequently chosen to investigate the etiological mechanisms and gene therapy for cancers in animal models. In this review, we summarized current advances of Sleeping Beauty transposon system in revealing molecular mechanism of cancers and improving gene therapy. Understanding molecular mechanisms by which driver mutations contribute to carcinogenesis and metastasis may pave the way for the development of innovative prophylactic and therapeutic strategies against malignant diseases.

  3. Sleeping Beauty transposon system for genetic etiological research and gene therapy of cancers

    Science.gov (United States)

    Hou, Xiaomei; Du, Yan; Deng, Yang; Wu, Jianfeng; Cao, Guangwen

    2015-01-01

    Carcinogenesis is etiologically associated with somatic mutations of critical genes. Recently, a number of somatic mutations and key molecules have been found to be involved in functional networks affecting cancer progression. Suitable animal models are required to validate cancer-promoting or -inhibiting capacities of these mutants and molecules. Sleeping Beauty transposon system consists of a transposon that carries gene(s) of interest and a transposase that recognizes, excises, and reinserts genes in given location of the genome. It can create both gain-of-function and loss-of-function mutations, thus being frequently chosen to investigate the etiological mechanisms and gene therapy for cancers in animal models. In this review, we summarized current advances of Sleeping Beauty transposon system in revealing molecular mechanism of cancers and improving gene therapy. Understanding molecular mechanisms by which driver mutations contribute to carcinogenesis and metastasis may pave the way for the development of innovative prophylactic and therapeutic strategies against malignant diseases. PMID:25455252

  4. Truth, virtue and beauty: midwifery and philosophy.

    Science.gov (United States)

    Parker, J M; Gibbs, M

    1998-09-01

    In this paper, we outline three moments in the history of Western philosophy--Classical Greek, Modernity, Postmodernity--and the ways in which issues of truth, virtue and beauty have been understood within these philosophical formations. In particular, we investigate the ways in which notions of truth, virtue and beauty influenced the orthodoxy of birthing practices at these different moments. Finally, we examine current, critical reflections on the role of the intellectual in postmodern society and use these reflections as a heuristic for understanding the role of the contemporary midwife. We suggest that midwifery must reconcile two divergent demands. The first is to mobilise the positive, instrumental benefits of Western medical science to improve mortality and morbidity outcomes. The second is to remain sensitive to the cultural and social meanings attached to traditional birthing practices and to understand the roles these play in the well-being of mother and child.

  5. The Hidden Beauty in Biomedical Imaging.

    Science.gov (United States)

    Barker, Norman; Iacobuzio-Donahue, Christine

    2015-01-01

    Caretakers, researchers and photographers working in a busy academic settings, every day are faced with images that are awe-inspiring for their beauty and for the terror they may represent to patients suffering from disease. Beauty in this context is a relative term. It may be seen as the delicate lacework of cells within the normal human brain reminiscent of a Jackson Pollack masterpiece, or the multitude of colors and textures formed by fungal organisms in a microbiology lab. Herein lies the juxtaposition image makers seek to represent. When contemplated in isolation, each represents a visually interesting image. However, when viewed with an awareness of the context in which the image was obtained, each image takes on the ability to evoke an alternative human emotion.

  6. Charm and beauty production at RHIC

    Energy Technology Data Exchange (ETDEWEB)

    Kabana, Sonia [Laboratoire de Physique Subatomique et des Technologies Associees (SUBATECH), Ecole des Mines, 4 rue Alfred Kastler, 44307 Nantes (France)

    2011-01-15

    We review selected highlights on charm and beauty production at RHIC from p+p, d+Au and A+A collisions at {radical}(s{sub NN})=200GeV, and compare them to model calculations. We focus on two particular issues, jet quenching and quarkonia. Anomalous energy loss (jet quenching) of quarks passing through the dense and hot matter built in heavy ion collisions is one of the outstanding discoveries made at RHIC. This phenomenon allows for an estimate of the initial gluon density. Furthermore, color screening of hidden charm and beauty states is a key signature of the QCD phase transition, allowing an estimate of the initial temperature. We present results on the flavour dependence of jet quenching. Heavy flavour production in A+A as compared to p+p collisions will be discussed for open and hidden charm.

  7. Hidden Beauty in Twisted Viking Neck Rings

    CERN Document Server

    Olsen, Kasper

    2010-01-01

    Many hoards found in Ireland, Scotland, Orkney Islands, and Scandinavia demonstrate the vikings ability to fabricate beautiful arm and neck rings of twisted silver and gold rods. Characteristic for such rings is the uniform appearance of the twisted pattern along the length of the arm ring, as well as from one arm ring to another, also when found at distant geographical locations. How can the appearance of the twisted wires be so perfectly repetitive? We demonstrate that the answer is that the vikings utilized a self-forming motif: The pattern arises from a twisting of the wires to a maximally rotated configuration. That is why the twist patterns in these arm and neck rings are beautiful, repetitive, and universal.

  8. Non-leptonic decays of beauty decays

    CERN Document Server

    Bigi, Ikaros I; Shifman, M; Uraltsev, N; Vainshtein, A I

    1994-01-01

    "Anyone who keeps the ability to see beauty never grows old" (Franz Kafka). In the last few years considerable progress has been achieved in our understanding of the decays of heavy flavour hadrons. One can now calculate inclusive transition rates in QCD proper through an expansion in inverse powers of the heavy flavour quark mass without recourse to phenomenological assumptions. The non-perturbative contributions are treated systematically in this way; they are found to produce corrections of order a few percent in beauty decays, i.e. typically somewhat smaller than the perturbative corrections. One finds, among other things: (a) The lifetime of $B^-$ mesons is predicted to be longer than that of $B^0$ mesons by several percent. (b) The QCD prediction for the semileptonic branching ratio of $B$ mesons appears to exceed present experimental values.

  9. China's Most Beautiful Books

    Institute of Scientific and Technical Information of China (English)

    WuLiang

    2005-01-01

    “China's Most Beautiful Books 2004”, an annual national award for books' graphic design, came out in Shanghai in January, 2005. Twenty-four publications won the titles and were recommended to participate in “The Most Beautiful Books of the World 2005” competition which will be held in Leibzig, Germany. The award winners included both best sellers with simplistic design such as “Us Three” and “Niu Niu: A Father's Notes”, and thread-bound traditional books such as “Ma De's Painting Album”, “Nanmu Carvings in West of Hunan Province”, “Watch the Three Gorges” and “Culture of Southeast China: Key Words”。

  10. "Beauty lies in the eye of the beholder"? Aspects of beauty and attractiveness.

    Science.gov (United States)

    Borelli, Claudia; Berneburg, Mirjam

    2010-05-01

    Discussing aesthetic issues and their management with patients is a growing area of dermatologic practice. Sometimes treatment options within one's own discipline are rapidly discussed, without a clear idea of the various aspects of the face which all combine to produce beauty and attractiveness. We review various features leading to the impression of beauty and attractiveness. Familiarity with these concepts should facilitate a broader discussion with the patient on the aspects of beauty and attractiveness beyond the borders of one's own discipline and also lead to multidisciplinary treatment options. We also examine the question how much the personality of the beholder himself is involved in the perception of attractiveness and beauty (of the person sitting opposite to him). The "ideal" face has an average profile with slightly protrusive and full lips. Attractiveness increases with average features and symmetry. Moreover, particular features such as the scheme of childlike characteristics combined with aspects of maturity and expression make a female face appear especially beautiful. Which attributes contribute to attractiveness of a man's face are controversial. Clear male signals such as a strong chin are likely not to increase attractiveness.

  11. Fibonacci, quasicrystals and the beauty of flowers.

    Science.gov (United States)

    Gardiner, John

    2012-12-01

    The appearance of Fibonacci sequences and the golden ratio in plant structures is one of the great outstanding puzzles of biology. Here I suggest that quasicrystals, which naturally pack in the golden ratio, may be ubiquitous in biological systems and introduce the golden ratio into plant phyllotaxy. The appearance of golden ratio-based structures as beautiful indicates that the golden ratio may play a role in the development of consciousness and lead to the aesthetic natural selection of flowering plants.

  12. Perceptions of beauty in Renaissance art.

    Science.gov (United States)

    Haughton, Neil

    2004-12-01

    The Renaissance was a cultural revolution that spread from Florence, in 1400, throughout Italy and into the rest of Europe. Its impetus was the philosophy of Humanism, which strove to resurrect and emulate the literature and art of the ancient Greeks and Romans. Artists had previously been limited to formulaic religious iconography. They now began to reproduce descriptions of classical paintings and copy the antique statues that were being newly rediscovered. The Renaissance artist's perception of beauty was therefore determined by his philosophical environment, his visual experience (the 'period eye'), the demands of his patrons and by attempts to enhance his professional status in society to equal that of poets and architects. The image of Venus portrayed by Botticelli as the idealization of beauty in Renaissance Florence is significantly different from the Venus portrayed by the German artist, Lucas Cranach. The northern European Venus is much less voluptuous than her Italian counterpart but is still inspired by humanist principals and retains considerable sexuality. Raphael's paintings epitomise the idealization of female beauty of this period but, by his own admission they were rarely based on real models. Often the same facial type was repeated in many different paintings. Indeed Renaissance portrait artists tended to avoid realistic interpretation, emphasizing instead the positive attributes of their subjects, both physical and political. Thus, Bronzino's Portrait of a Young Man not only depicts his subject's idealized appearance but also his scholarship, background and potential. The depiction of beauty in Renaissance art is shown to be more complex than a mere photograph-like representation of sexuality or of a person's physical appearance. Instead, Renaissance art created physically perfect images resulting from scholarly expectation, the artist's ambitions and his developing skills.

  13. Beautiful seasons of Pan’an

    Institute of Scientific and Technical Information of China (English)

    季陈熙; 陈妙芳

    2015-01-01

    I.m from Pan an,It s a small town of Zhejiang.Do you know?It s the most beautiful palce in my heart.Panan is a bes place to live.In Pan an,The water is clean,the trees are green,the air is very fresh.In an increasingly harsh environment,PM2.5 is also rampant worldwide,Pan an is getting more and more popula

  14. Beauty and ugliness in Olmec monumental sculpture

    OpenAIRE

    Baudez, Claude-François

    2015-01-01

    Beauty and ugliness in Olmec monumental sculpture. Since our Western art tradition has put such a prize on naturalism, we tend to think that other civilizations valued it as much as we did and do. I contend that Olmec monumental art illustrates the opposite, and suggest that the Olmecs most appreciated the anthropomorphic statues that incorporated feline features, and disliked the very naturalistic style of the colossal heads. The latter represented the severed heads of opponents who probably...

  15. Measurement of the beauty of periodic noises

    CERN Document Server

    Manet, Vincent

    2012-01-01

    In this article indicators to describe the "beauty" of noises are proposed. Rhythmic, tonal and harmonic suavity are introduced. They give a characterization of a noise in terms of rhythmic regularity (rhythmic suavity), of auditory pleasure of the "chords" constituting the signal (tonal suavity) and of the transition between the chords (harmonic suavity). These indicators have been developed for periodic noises typically issued from rotating machines such as engines, compressors... and are now used by our industrial customers since two years.

  16. BEAUTY IN THE AGE OF MARKETING

    OpenAIRE

    Bingqing Yin; Susie Pryor

    2012-01-01

    Research has repeatedly demonstrated that beauty is positively related to a number of important outcomes including social and personal power, self-esteem, and preferential treatment from others (Bloch and Richins, 1992; cf. Adams, 1977; Goldman and Lewis, 1977). Moreover, studies consistently suggest that the use of physically attractive models results in positive effects (Berscheid and Walster, 1974; Bower, 2011; Buunk and Dijkstra, 2011; Landy and Sigall, 1974). Accordingly, advertisers uti...

  17. Fibonacci, quasicrystals and the beauty of flowers

    Science.gov (United States)

    Gardiner, John

    2012-01-01

    The appearance of Fibonacci sequences and the golden ratio in plant structures is one of the great outstanding puzzles of biology. Here I suggest that quasicrystals, which naturally pack in the golden ratio, may be ubiquitous in biological systems and introduce the golden ratio into plant phyllotaxy. The appearance of golden ratio-based structures as beautiful indicates that the golden ratio may play a role in the development of consciousness and lead to the aesthetic natural selection of flowering plants. PMID:23072998

  18. ''Beauty of Wholeness and Beauty of Partiality.'' New Terms Defining the Concept of Beauty in Architecture in Terms of Sustainability and Computer Aided Design

    Science.gov (United States)

    Farid, Ayman A.; Zaghloul, Weaam M.; Dewidar, Khaled M.

    2014-01-01

    The great shift in sustainability and computer aided design in the field of architecture caused a remarkable change in the architecture philosophy, new aspects of beauty and aesthetic values are being introduced, and traditional definitions for beauty cannot fully cover this aspects, which causes a gap between; new architecture works criticism and…

  19. Beautiful, but also potentially invasive

    Directory of Open Access Journals (Sweden)

    Lipták Boris

    2015-03-01

    Full Text Available Introduction of non-indigenous exotic species to new areas, where they may establish viable populations and become invasive, is a considerable problem in the protection of nature worldwide, as these species may alter the indigenous species population structure and potentially even decrease the biodiversity. The European fauna underwent through major negative changes on the continent and nowadays, it experiences another new treat, represented by the expanding aquarium pet trade, and with it, associated species (and disease introductions. Exotic freshwater crustaceans are one of the taxa widely incorporated in the business, counting a remarkable number of species. Recent records of the exotic marbled crayfish or Marmorkrebs (Procambarus fallax f. virginalis in German in open ecosystems in Slovakia pointed to human-mediated introductions associated with aquarium pet trade in the country. In this regard, a study of the aquarium pet trade both in expositions and shops and online was assessed. Several crustacean taxa are available both in pet trade exhibitions and online through the Internet. Altogether 26 different species were identified in the aquarium trade in Slovakia. These are Procambarus fallax f. virginalis, P. clarkii, P. alleni, Cherax quadricarinatus, C. destructor, C. holthuisi, C. peknyi, Cambarellus patzcuarensis and C. diminutus occurring in the aquarium pet trade in Slovakia (n = 9. Procambarus fallax f. virginalis, P. clarkii and C. patzuarensis are the most common in this regard. There is also a quantity of other related taxa in the aquarium pet trade in Slovakia, mainly Caridina spp. (n = 5, Neocaridina spp. (n = 4, Atyopsis moluccensis, Atya gabonensis, Arachnochium kulsiense and several taxa of exotic crabs (n = 5 belonging to three different genera (Cardiosoma, Geosesarma and Gecarinus present. Neocaridina davidi is identified as the most frequent in this regard. As some of the species can become established and form viable

  20. Therapeutic efficacy of improved α-fetoprotein promoter-mediated tBid delivered by folate-PEI600-cyclodextrin nanopolymer vector in hepatocellular carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Hu, Bao-guang [Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR (Hong Kong); Department of Gastrointestinal Surgery, the Affiliated Hospital of Binzhou Medical University, Binzhou, Shandong (China); Liu, Li-ping [Department of Hepatobiliary and Pancreas Department of Hepatobiliary Surgery, the Second Clinical Medical College of Jinan University (Shenzhen People' s Hospital), Shenzhen, Guangdong Province (China); Chen, George G., E-mail: gchen@cuhk.edu.hk [Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR (Hong Kong); Ye, Cai Guo; Leung, Kevin K.C.; Ho, Rocky L.K.; Lin, Marie C.; Lai, Paul B.S. [Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR (Hong Kong)

    2014-06-10

    SNPs in human AFP promoter are associated with serum AFP levels in hepatocellular carcinoma (HCC), suggesting that AFP promoter variants may generate better transcriptional activities while retaining high specificity to AFP-producing cells. We sequenced human AFP promoters, cloned 15 different genotype promoters and tested their reporter activities in AFP-producing and non-producing cells. Among various AFP variant fragments tested, EA4D exhibited the highest reporter activity and thus was selected for the further study. EA4D was fused with tBid and coupled with nano-particle vector (H1) to form pGL3-EA4D-tBid/H1. pGL3-EA4D-tBid/H1 could express a high level of tBid while retain the specificity to AFP-producing cells. In a HCC tumor model, application of pGL3-EA4D-tBid/H1 significantly inhibited the growth of AFP-producing-implanted tumors with minimal side-effects, but had no effect on non-AFP-producing tumors. Furthermore, pGL3-EA4D-tBid/H1 could significantly sensitize HCC cells to sorafenib, an approved anti-HCC agent. Collectively, pGL3-EA4D-tBid/H1, a construct with the AFP promoter EA4D and the novel H1 delivery system, can specifically target and effectively suppress the AFP-producing HCC. This new therapeutic tool shows little toxicity in vitro and in vivo and it should thus be safe for further clinical tests. - Highlights: • The nano-particle vector H1 has advantages in mediating gene therapy construct pGL3-EA4D-tBid for HCC treatment. • pGL3-EA4D-tBid/H1, a construct with the AFP promoter EA4D, can specifically target the AFP-producing HCC. • pGL3-EA4D-tBid/H1effectively suppresses the proliferation and growth of AFP-producing HCC. • This novel pGL3-EA4D-tBid/H1 therapeutic tool shows little toxicity in vitro and in vivo.

  1. ICTR-PHE Public Talk | Physics is beautiful and useful by Ugo Amaldi | 11 February

    CERN Multimedia

    2014-01-01

    In the framework of the International Conference on Translational Research in Radiation Oncology – Physics for Health in Europe (ICTR-PHE, see here), which will take place at the Geneva International Conference Centre from 10 to 14 February 2014, the public is invited to attend an exceptional talk:   Physics is beautiful and useful by Ugo Amaldi Tuesday 11 February 2014, 6.30 p.m. Geneva International Conference Centre 17, rue de Varembé, Geneva *The talk will be in English with simultaneous translation into French* Abstract: The year 2014 marks the 60th anniversary of CERN and of the first cancer treatment with protons done at Berkeley. This is no coincidence: indeed, the beauty of particle physics has always gone hand in hand with useful applications. These “useful” activities follow from the technical developments in particle accelerators and radiation detectors that have brought about the discoveries of neutral currents (1973), of its mediator the...

  2. The Most Beautiful Heart%最美丽的心

    Institute of Scientific and Technical Information of China (English)

    章纯

    2010-01-01

    @@ One day a young man was standing in the middle of the town proclaiming that he had the most beautiful heart in the whole valley.A large crowd gathered and they all admired his heart for it was perfect.There was not a mark or a flaw in it.Yes,they all agreed it truly was the most beautiful heart they had ever seen.The young man was very proud and boasted1 more loudly about his beautiful heart.

  3. Therapeutic ultrasound

    Energy Technology Data Exchange (ETDEWEB)

    Crum, Lawrence A [Center for Industrial and Medical Ultrasound, 1013 NE 40th Street, University of Washington, Seattle, WA 98105 (United States)

    2004-01-01

    The use of ultrasound in medicine is now quite commonplace, especially with the recent introduction of small, portable and relatively inexpensive, hand-held diagnostic imaging devices. Moreover, ultrasound has expanded beyond the imaging realm, with methods and applications extending to novel therapeutic and surgical uses. These applications broadly include: tissue ablation, acoustocautery, lipoplasty, site-specific and ultrasound mediated drug activity, extracorporeal lithotripsy, and the enhancement of natural physiological functions such as wound healing and tissue regeneration. A particularly attractive aspect of this technology is that diagnostic and therapeutic systems can be combined to produce totally non-invasive, imageguided therapy. This general lecture will review a number of these exciting new applications of ultrasound and address some of the basic scientific questions and future challenges in developing these methods and technologies for general use in our society. We shall particularly emphasize the use of High Intensity Focused Ultrasound (HIFU) in the treatment of benign and malignant tumors as well as the introduction of acoustic hemostasis, especially in organs which are difficult to treat using conventional medical and surgical techniques. (amum lecture)

  4. Therapeutic efficacy of boron neutron capture therapy mediated by boron-rich liposomes for oral cancer in the hamster cheek pouch model.

    Science.gov (United States)

    Heber, Elisa M; Hawthorne, M Frederick; Kueffer, Peter J; Garabalino, Marcela A; Thorp, Silvia I; Pozzi, Emiliano C C; Monti Hughes, Andrea; Maitz, Charles A; Jalisatgi, Satish S; Nigg, David W; Curotto, Paula; Trivillin, Verónica A; Schwint, Amanda E

    2014-11-11

    The application of boron neutron capture therapy (BNCT) mediated by liposomes containing (10)B-enriched polyhedral borane and carborane derivatives for the treatment of head and neck cancer in the hamster cheek pouch oral cancer model is presented. These liposomes are composed of an equimolar ratio of cholesterol and 1,2-distearoyl-sn-glycero-3-phosphocholine, incorporating K[nido-7-CH3(CH2)15-7,8-C2B9H11] (MAC) in the bilayer membrane while encapsulating the hydrophilic species Na3[ae-B20H17NH3] (TAC) in the aqueous core. Unilamellar liposomes with a mean diameter of 83 nm were administered i.v. in hamsters. After 48 h, the boron concentration in tumors was 67 ± 16 ppm whereas the precancerous tissue contained 11 ± 6 ppm, and the tumor/normal pouch tissue boron concentration ratio was 10:1. Neutron irradiation giving a 5-Gy dose to precancerous tissue (corresponding to 21 Gy in tumor) resulted in an overall tumor response (OR) of 70% after a 4-wk posttreatment period. In contrast, the beam-only protocol gave an OR rate of only 28%. Once-repeated BNCT treatment with readministration of liposomes at an interval of 4, 6, or 8 wk resulted in OR rates of 70-88%, of which the complete response ranged from 37% to 52%. Because of the good therapeutic outcome, it was possible to extend the follow-up of BNCT treatment groups to 16 wk after the first treatment. No radiotoxicity to normal tissue was observed. A salient advantage of these liposomes was that only mild mucositis was observed in dose-limiting precancerous tissue with a sustained tumor response of 70-88%.

  5. Beauty in abstract paintings: Perceptual contrast and statistical properties

    Directory of Open Access Journals (Sweden)

    Birgit eMallon

    2014-03-01

    Full Text Available In this study, we combined the behavioral and objective approach in the field of empirical aesthetics. First, we studied the perception of beauty by investigating shifts in evaluation on perceived beauty of abstract artworks (Experiment 1. Because the participants showed heterogeneous individual preferences for the paintings, we divided them into seven clusters for the test. The experiment revealed a clear pattern of perceptual contrast. The perceived beauty of abstract paintings increased after exposure to paintings that were rated as less beautiful, and it decreased after exposure to paintings that were rated as more beautiful. Next, we searched for correlations of beauty ratings and perceptual contrast with statistical properties of abstract artworks (Experiment 2. The participants showed significant preferences for certain image properties. These preferences differed between the clusters of participants. Strikingly, next to color measures like hue, saturation, value and lightness, the recently described PHOG self-similarity value seems to be a predictor for aesthetic appreciation of abstract artworks. We speculate that the shift in evaluation in Experiment 1 was, at least in part, based on low-level adaptation to some of the statistical image properties analyzed in Experiment 2. In conclusion, our findings demonstrate that the perception of beauty in abstract artworks is altered after exposure to beautiful or non-beautiful images and correlates with particular image properties, especially color measures and self-similarity.

  6. Beauty in abstract paintings: perceptual contrast and statistical properties.

    Science.gov (United States)

    Mallon, Birgit; Redies, Christoph; Hayn-Leichsenring, Gregor U

    2014-01-01

    In this study, we combined the behavioral and objective approach in the field of empirical aesthetics. First, we studied the perception of beauty by investigating shifts in evaluation on perceived beauty of abstract artworks (Experiment 1). Because the participants showed heterogeneous individual preferences for the paintings, we divided them into seven clusters for the test. The experiment revealed a clear pattern of perceptual contrast. The perceived beauty of abstract paintings increased after exposure to paintings that were rated as less beautiful, and it decreased after exposure to paintings that were rated as more beautiful. Next, we searched for correlations of beauty ratings and perceptual contrast with statistical properties of abstract artworks (Experiment 2). The participants showed significant preferences for particular image properties. These preferences differed between the clusters of participants. Strikingly, next to color measures like hue, saturation, value and lightness, the recently described Pyramid of Histograms of Orientation Gradients (PHOG) self-similarity value seems to be a predictor for aesthetic appreciation of abstract artworks. We speculate that the shift in evaluation in Experiment 1 was, at least in part, based on low-level adaptation to some of the statistical image properties analyzed in Experiment 2. In conclusion, our findings demonstrate that the perception of beauty in abstract artworks is altered after exposure to beautiful or non-beautiful images and correlates with particular image properties, especially color measures and self-similarity.

  7. Beauty in abstract paintings: perceptual contrast and statistical properties

    Science.gov (United States)

    Mallon, Birgit; Redies, Christoph; Hayn-Leichsenring, Gregor U.

    2014-01-01

    In this study, we combined the behavioral and objective approach in the field of empirical aesthetics. First, we studied the perception of beauty by investigating shifts in evaluation on perceived beauty of abstract artworks (Experiment 1). Because the participants showed heterogeneous individual preferences for the paintings, we divided them into seven clusters for the test. The experiment revealed a clear pattern of perceptual contrast. The perceived beauty of abstract paintings increased after exposure to paintings that were rated as less beautiful, and it decreased after exposure to paintings that were rated as more beautiful. Next, we searched for correlations of beauty ratings and perceptual contrast with statistical properties of abstract artworks (Experiment 2). The participants showed significant preferences for particular image properties. These preferences differed between the clusters of participants. Strikingly, next to color measures like hue, saturation, value and lightness, the recently described Pyramid of Histograms of Orientation Gradients (PHOG) self-similarity value seems to be a predictor for aesthetic appreciation of abstract artworks. We speculate that the shift in evaluation in Experiment 1 was, at least in part, based on low-level adaptation to some of the statistical image properties analyzed in Experiment 2. In conclusion, our findings demonstrate that the perception of beauty in abstract artworks is altered after exposure to beautiful or non-beautiful images and correlates with particular image properties, especially color measures and self-similarity. PMID:24711791

  8. Challenges and Countermeasures for Beautiful Countryside Construction in China

    Directory of Open Access Journals (Sweden)

    LIU Yan-sui

    2015-04-01

    Full Text Available The 18th National Congress of Communist Party of China proposed the goal of building a beautiful China. The key points and difficulties of beautiful China construction lie in countryside. Beautiful countryside construction is an important integral part of the beauty of China. Under the background of rapid urbanization, industrialization and rural transformative development, beautiful countryside construction has a vital practical significance for renovating hollowed villages, improving rural living environment, reconstructing rural space and narrowing rural-urban income gap as well as promoting rural-urban integrated development. However, the construction of China's beautiful countryside is facing many challenges, i.e., population emigration, employment, land use, resource consumption and environmental governance. In this study, the strategies and outlets to solve the beautiful countryside construction problems were put forward based on the objective analysis of challenges and plights faced by beautiful countryside construction. It would provide a theoretical basis for exploring the geographical patterns of rebalancing the man-land relationship from uncoordinated mode. These findings would also provide a scientific decision support for constructing beautiful countryside construction in new period.

  9. The True Bride: Perceptions of Beauty and Feminine Virtue in Folktales.

    Science.gov (United States)

    Trousdale, Ann

    1989-01-01

    Discusses the quality of the heroines' beauty in several folktales from various cultures. Notes that, unlike Western cultures that equate physical beauty with virtue, in many cultures, beauty is viewed as spiritual and emotional as well as physical. (MM)

  10. [Beauty judgment: review of the literature].

    Science.gov (United States)

    Faure, Jacques; Bolender, Yves

    2014-03-01

    Esthetic judgments are surely subjective, but as surely, that does not preclude them being studied objectively through rigorous scientific methods. The factual basis of a science of esthetics is not to settle whether some person or image is "objectively beautiful" but rather to determine whether some representative set or sets of individuals judge or experience him/her/it as beautiful or unattractive. The aim of this paper is to review the definitional, theoretical and methodological aspects pertaining to the perception of facial/dental attractiveness by a group of representative individuals. The first part lays down the basic principles of the perception of facial/dental attractiveness: the perception involves a jury, a field of investigation and a test providing quantitative data; the following general determinants of beauty perception are reviewed: the average morphology, the judge's cultural background, the numerology, the judge's ethnical origin. Indirect determinants are the dentition, the osseous architecture and the muscular envelope. Some disruptive factors might alter the judges' facial perception. They might be qualified as either peripheral to the face or psycho-social factors. Peripheral factors include hair style and color, skin hue, wrinkles, lips color... Psycho-social factors cover the personality of the subject being evaluated, his/her intelligence or behavior. The second part deals specifically with the methodology used to determine facial attractiveness and to correlate this latter with a specific morphology. Typically such a study aims to determine average esthetic preferences for some set of visual displays among a particular jury, given a specific task to judge esthetic quality or qualities. The sample being studied, the displays, the jury or jurys, the rating procedure must all be specified prior to collecting data. A specific emphasis will be given to the rating process and the associated morphometrics, the ultimate goal being to

  11. On the beauty of nature, paintings and music

    Directory of Open Access Journals (Sweden)

    Ekin Çoraklı

    2014-07-01

    Full Text Available There is a wide range of things that are classified by humans in terms of their level of beauty. The word ‘beautiful’ is used to define some of the natural entities living and nonliving, unnatural objects or ideas produced by humans, and the works of art, which are unique products of human hand and brain. Beauty, as a concept awakening a common feeling of pleasure, may mean something deeper than we are aware of. This meaning is perhaps hidden in its deeper aspects, which we have to give effort to analyze. Hence, within context of this paper, common and specific properties of the beauty of nature, paintings and music will be discussed. In addition, the stages of the perception of the beauty of all kinds will be called into question, and an account about the process of the judgment of beauty will be suggested. The specific types of beauty analyzed through the paper are limited with the beauty of nature, paintings and absolute music (music without words, following an opening remark about the beauty in general.

  12. Gender Differences in the Motivational Processing of Facial Beauty

    Science.gov (United States)

    Levy, Boaz; Ariely, Dan; Mazar, Nina; Chi, Won; Lukas, Scott; Elman, Igor

    2008-01-01

    Gender may be involved in the motivational processing of facial beauty. This study applied a behavioral probe, known to activate brain motivational regions, to healthy heterosexual subjects. Matched samples of men and women were administered two tasks: (a) key pressing to change the viewing time of average or beautiful female or male facial…

  13. Beauty: A Concept with Practical Implications for Teacher Researchers

    Science.gov (United States)

    Winston, Joe

    2011-01-01

    Hillman's (2001) simple affirmation that "an idea of beauty is useful, functional, practical" is one this article attempts to pursue with teacher researchers in mind, based on the belief that to move from the "re"pression of beauty to its "ex"pression--or, at the very least, to its articulation--will enlighten rather than distract individuals. The…

  14. Preschoolers' Ideas of What Makes a Picture Book Illustration Beautiful

    Science.gov (United States)

    House, Carolyn A.; Rule, Audrey C.

    2005-01-01

    Preschoolers' reasons for ranking the beauty of 30 children's book illustrations were investigated through individual interviews. Most frequent response criteria for beauty were associated with familiar objects or surroundings, action, color, clothing or accessories, water or ice, body features, and babies or small things. Children's book…

  15. Teaching the Psychology of Engagement with Beauty: State and Trait

    Science.gov (United States)

    Diessner, Rhett; Kirk, Cameron; Guenthner, Crystn; Pohling, Rico; Mobasher, Saman

    2017-01-01

    An undergraduate senior-level course, the psychology of beauty, taught within the positive psychology approach, was designed with the aim to increase state and trait levels of engagement with beauty among its students. The course was a service-learning course in which students were paired by the Area Agency on Aging with elders in the greater…

  16. The neural correlates of beauty comparison.

    Science.gov (United States)

    Kedia, Gayannée; Mussweiler, Thomas; Mullins, Paul; Linden, David E J

    2014-05-01

    Beauty is in the eye of the beholder. How attractive someone is perceived to be depends on the individual or cultural standards to which this person is compared. But although comparisons play a central role in the way people judge the appearance of others, the brain processes underlying attractiveness comparisons remain unknown. In the present experiment, we tested the hypothesis that attractiveness comparisons rely on the same cognitive and neural mechanisms as comparisons of simple nonsocial magnitudes such as size. We recorded brain activity with functional magnetic resonance imaging (fMRI) while participants compared the beauty or height of two women or two dogs. Our data support the hypothesis of a common process underlying these different types of comparisons. First, we demonstrate that the distance effect characteristic of nonsocial comparisons also holds for attractiveness comparisons. Behavioral results indicated, for all our comparisons, longer response times for near than far distances. Second, the neural correlates of these distance effects overlapped in a frontoparietal network known for its involvement in processing simple nonsocial quantities. These results provide evidence for overlapping processes in the comparison of physical attractiveness and nonsocial magnitudes.

  17. Structural Determinants of Sleeping Beauty Transposase Activity.

    Science.gov (United States)

    Abrusán, György; Yant, Stephen R; Szilágyi, András; Marsh, Joseph A; Mátés, Lajos; Izsvák, Zsuzsanna; Barabás, Orsolya; Ivics, Zoltán

    2016-08-01

    Transposases are important tools in genome engineering, and there is considerable interest in engineering more efficient ones. Here, we seek to understand the factors determining their activity using the Sleeping Beauty transposase. Recent work suggests that protein coevolutionary information can be used to classify groups of physically connected, coevolving residues into elements called "sectors", which have proven useful for understanding the folding, allosteric interactions, and enzymatic activity of proteins. Using extensive mutagenesis data, protein modeling and analysis of folding energies, we show that (i) The Sleeping Beauty transposase contains two sectors, which span across conserved domains, and are enriched in DNA-binding residues, indicating that the DNA binding and endonuclease functions of the transposase coevolve; (ii) Sector residues are highly sensitive to mutations, and most mutations of these residues strongly reduce transposition rate; (iii) Mutations with a strong effect on free energy of folding in the DDE domain of the transposase significantly reduce transposition rate. (iv) Mutations that influence DNA and protein-protein interactions generally reduce transposition rate, although most hyperactive mutants are also located on the protein surface, including residues with protein-protein interactions. This suggests that hyperactivity results from the modification of protein interactions, rather than the stabilization of protein fold.

  18. The end of Sleeping Beauty's nightmare

    CERN Document Server

    Groisman, Berry

    2008-01-01

    The way a rational agent changes her belief in certain propositions/hypotheses in the light of new evidence lies at the heart of Bayesian inference. The basic natural assumption, as summarized in van Fraassen's Reflection Principle ([1984]), would be that in the absence of new evidence the belief should not change. Yet, there are examples that are claimed to violate this assumption. The apparent paradox presented by such examples, if not settled, would demonstrate the inconsistency and/or incompleteness of the Bayesian approach and without eliminating this inconsistency, the approach cannot be regarded as scientific. The Sleeping Beauty Problem is just such an example. The existing attempts to solve the problem fall into three categories. The first two share the view that new evidence is absent, but differ about the conclusion of whether Sleeping Beauty should change her belief or not, and why. The third category is characterized by the view that, after all, new evidence (although hidden from the initial view...

  19. The beauty of the physical world

    CERN Multimedia

    CERN Bulletin

    2010-01-01

    Graham Farmelo, author and former particle physicist, visited CERN on 25 March. To the CERNois gathered in the Main Auditorium, he talked about his new book The Strangest Man, a biography of Paul Dirac. Dirac was obsessed by the importance of mathematical beauty in fundamental physics, a belief that was “almost a religion” to him. Farmelo himself has no doubts: among all of the natural phenomena the LHC may unveil, supersymmetry is the most beautiful.   Talking about the life of a physicist to draw the attention of the public to the science: that was the idea behind Graham Farmelo decision to write a biography of Paul Dirac. The book won the 2009 Costa Biography Award. “I chose Paul Dirac because he was the first truly modern theoretical physicist but he is virtually unknown to the public”, explains Graham Farmelo. “Dirac had a fascinating life. He was not born in a wealthy or a particularly brilliant family but he ended up conceiving in his head ...

  20. The experience of mathematical beauty and its neural correlates.

    Science.gov (United States)

    Zeki, Semir; Romaya, John Paul; Benincasa, Dionigi M T; Atiyah, Michael F

    2014-01-01

    Many have written of the experience of mathematical beauty as being comparable to that derived from the greatest art. This makes it interesting to learn whether the experience of beauty derived from such a highly intellectual and abstract source as mathematics correlates with activity in the same part of the emotional brain as that derived from more sensory, perceptually based, sources. To determine this, we used functional magnetic resonance imaging (fMRI) to image the activity in the brains of 15 mathematicians when they viewed mathematical formulae which they had individually rated as beautiful, indifferent or ugly. Results showed that the experience of mathematical beauty correlates parametrically with activity in the same part of the emotional brain, namely field A1 of the medial orbito-frontal cortex (mOFC), as the experience of beauty derived from other sources.

  1. The experience of mathematical beauty and its neural correlates

    Directory of Open Access Journals (Sweden)

    Semir eZeki

    2014-02-01

    Full Text Available Many have written of the experience of mathematical beauty as being comparable to that derived from the greatest art. This makes it interesting to learn whether the experience of beauty derived from such a highly intellectual and abstract source such as mathematics correlates with activity in the same part of the emotional brain as that derived from more sensory, perceptually based, sources. To determine this, we used functional magnetic resonance imaging (fMRI to image the activity in the brains of 15 mathematicians when they viewed mathematical formulae which they had individually rated as beautiful, indifferent or ugly. Results showed that the experience of mathematical beauty correlates parametrically with activity in the same part of the emotional brain, namely field A1 of the medial orbito-frontal cortex (mOFC, as the experience of beauty derived from other sources.

  2. Online Responses to a Multilingual Super Bowl Ad: Is "America the Beautiful" by Any Other Language Still America, the Beautiful?

    Science.gov (United States)

    Hoffman, Brooke Y.

    2016-01-01

    On 2 February 2014, an advertisement entitled "It's Beautiful" debuted during Super Bowl XLVIII, which was watched by 111.5 million people in the USA. The Coca-Cola advertisement portrayed people of various ethnicities and was accompanied by "America the Beautiful" sung in nine languages. Using critical discourse analysis, I…

  3. THE BEAUTY OF THE WORLD IN PLATO’S TIMAEUS

    Directory of Open Access Journals (Sweden)

    O’Meara, Dominic

    2014-01-01

    Full Text Available In the Timaeus Plato describes the world as the ‘most beautiful’ (kallistos, 29a5 of generated things. Perhaps indeed this is the first systematic description of the beauty of the world. It is, at any rate, one of the most influential statements of the theme. The Stoics were deeply convinced by it and later, in the third century A.D., at a time when contempt and hate for the world were propagated by Gnostic movements, Plotinus, interpreting the Timaeus, would write magnificent passages on the beauty and value of the world. But what does Plato mean by the ‘beauty’ of the world? What makes the world beautiful? In this paper these questions are approached first (1 by a brief discussion of the distinction which Plato appears to make in the Timaeus between beauty and the good. In one passage (Tim. 87c ‘measure’ seems to relate to this distinction. It is suitable then (2 to look at a section of another late work of Plato, the Philebus, where the themes of beauty, goodness and measure may be compared in more detail. The theme of measure then takes us back (3 to the Timaeus, in order to examine the role played by measure, in particular mathematical measure, in constituting the beauty of the world. I discuss in detail the way in which mathematical structures make for the beauty of soul and body in the living whole that is the world.

  4. Literary aesthetics: beauty, the brain, and Mrs. Dalloway.

    Science.gov (United States)

    Hogan, Patrick Colm

    2013-01-01

    Empirical research indicates that beauty is in part a matter of prototype approximation. Some research suggests that unanticipated pattern recognition is important as well. This essay begins by briefly outlining an account of beauty based on these factors. It goes on to consider complications. Minor complications include the partial incompatibility of these accounts and the importance of differentiating judgments of beauty from aesthetic response. More serious issues include the relative neglect of literature in neurologically-based discussions of beauty, which tend to focus on music or visual art. There is also a relative neglect of emotion, beyond the reward system. Finally, there is the almost complete absence of the sublime. After considering these problems broadly, the essay turns to Virginia Woolf's Mrs. Dalloway, examining its treatment of beauty and sublimity. The aim of this section is not merely to illuminate Woolf's novel by reference to neuroscientific research. It is equally, perhaps more fully, to expand our neuroscientifically grounded account of aesthetic response by drawing on Woolf's novel. In Mrs. Dalloway, there are gestures toward prototypes and patterns in beauty. But the key features are clearly emotional. Specifically, the emotions at issue in feelings of beauty and sublimity appear to be primarily attachment, on the one hand, and a profound sense of isolation, on the other. Woolf's novel also points us toward other features of aesthetic experience, crucially including the emotion-sharing that is a key function of the production and circulation of art.

  5. Fractal Beauty in Xinjiang Folk Art Patterns

    Institute of Scientific and Technical Information of China (English)

    PENG Hong; ZHAO Hai-ying

    2014-01-01

    Xinjiang folk art patterns and designs are the art treasures of Chinese cultural treasure-house as well as the precious humanistic resources of Western China. In the process of collecting, sorting out and studying Xinjiang folk art patterns, the elegant simplicity as well as the good taste stands out impressively, and the pattern shape as well as the layout composition shows a distinctive national trait and a strong local color. As “The Geometry of Nature”, fractal geometry brings about a new performing method. Various fractal graphs are created by different generators. Their dynamic pictures contain visual information of great magnitude and their artistic effect is similar to Xinjiang folk art patterns, which fully proves the fractal beauty in Xinjiang folk art patterns.

  6. The 2012 interferometric imaging beauty contest

    Science.gov (United States)

    Baron, Fabien; Cotton, William D.; Lawson, Peter R.; Ridgway, Steve T.; Aarnio, Alicia; Monnier, John D.; Hofmann, Karl-Heinz; Schertl, Dieter; Weigelt, Gerd; Thiébaut, Eric; Soulez, Férréol; Mary, David; Millour, Florentin; Vannier, Martin; Young, John; Elias, Nicholas M.; Schmitt, Henrique R.; Rengaswamy, Sridharan

    2012-07-01

    We present the results of the fifth Interferometric Imaging Beauty Contest. The contest consists in blind imaging of test data sets derived from model sources and distributed in the OIFITS format. Two scenarios of imaging with CHARA/MIRC-6T were offered for reconstruction: imaging a T Tauri disc and imaging a spotted red supergiant. There were eight different teams competing this time: Monnier with the software package MACIM; Hofmann, Schertl and Weigelt with IRS; Thiebaut and Soulez with MiRA ; Young with BSMEM; Mary and Vannier with MIROIRS; Millour and Vannier with independent BSMEM and MiRA entries; Rengaswamy with an original method; and Elias with the radio-astronomy package CASA. The contest model images, the data delivered to the contestants and the rules are described as well as the results of the image reconstruction obtained by each method. These results are discussed as well as the strengths and limitations of each algorithm.

  7. The 2010 Interferometric Imaging Beauty Contest

    CERN Document Server

    Malbet, Fabien; Duvert, Gilles; Lawson, Peter; Chiavassa, Andrea; Young, John; Baron, Fabien; Buscher, David; Rengaswamy, Sridharan; Kloppenborg, Brian; Vannier, Martin; Mugnier, Laurent

    2010-01-01

    We present the results of the fourth Optical/IR Interferometry Imaging Beauty Contest. The contest consists of blind imaging of test data sets derived from model sources and distributed in the OI-FITS format. The test data consists of spectral data sets on an object "observed" in the infrared with spectral resolution. There were 4 different algorithms competing this time: BSMEM the Bispectrum Maximum Entropy Method by Young, Baron & Buscher; RPR the Recursive Phase Reconstruction by Rengaswamy; SQUEEZE a Markov Chain Monte Carlo algorithm by Baron, Monnier & Kloppenborg; and, WISARD the Weak-phase Interferometric Sample Alternating Reconstruction Device by Vannier & Mugnier. The contest model image, the data delivered to the contestants and the rules are described as well as the results of the image reconstruction obtained by each method. These results are discussed as well as the strengths and limitations of each algorithm.

  8. The 2012 Interferometric Imaging Beauty Contest

    CERN Document Server

    Baron, Fabien; Lawson, Peter R; Ridgway, Steve T; Aarnio, Alicia; Monnier, John D; Hofmann, Karl-Heinz; Schertl, Dieter; Weigelt, Gerd; Thiébaut, Eric; Soulez, Férréol; Mary, David; Millour, Florentin; Vannier, Martin; Young, John; Elias, Nicholas M; Schmitt, Henrique R; Rengaswamy, Sridharan

    2012-01-01

    We present the results of the fifth Interferometric Imaging Beauty Contest. The contest consists in blind imaging of test data sets derived from model sources and distributed in the OIFITS format. Two scenarios of imaging with CHARA/MIRC-6T were offered for reconstruction: imaging a T Tauri disc and imaging a spotted red supergiant. There were eight different teams competing this time: Monnier with the software package MACIM; Hofmann, Schertl and Weigelt with IRS; Thi\\'ebaut and Soulez with MiRA ; Young with BSMEM; Mary and Vannier with MIROIRS; Millour and Vannier with independent BSMEM and MiRA entries; Rengaswamy with an original method; and Elias with the radio-astronomy package CASA. The contest model images, the data delivered to the contestants and the rules are described as well as the results of the image reconstruction obtained by each method. These results are discussed as well as the strengths and limitations of each algorithm.

  9. Why Beauty Still Cannot Be Measured

    Directory of Open Access Journals (Sweden)

    Ossi Naukkarinen

    2010-01-01

    Full Text Available This article focuses on the question of whether the latest results achieved in sciences such as evolution studies and brain research can help us understand the nature of aesthetic judgments. It suggests that such approaches may offer interesting insights for understanding many problems in aesthetics, but for clarifying aesthetic judgments one needs a philosophical point of view. Aesthetic judgments cannot be proven right or wrong by scientific methods, and beauty or other aesthetic qualities cannot be directly measured. The “method” of both making and analyzing aesthetic judgments is discussion, and the article clarifies why this is still the case, even if empirical, non-philosophical scientific methods are more accurate than ever before.

  10. Truth and beauty in contemporary urban photography

    Directory of Open Access Journals (Sweden)

    Daniele Colistra

    2014-05-01

    Full Text Available Does city still need photography? Or does it show itself more effectively through other forms of communication? The question brings us back almost two hundred years ago, at the time of the spread of the first daguerreotypes, when the query was: Does city still need painting? The question raises several other issues - truth and beauty, analogical and digital, truth and photo editing - that this essay examines by comparing some images. We are convinced that “the more we can speak of a picture, the more unlikely it is to speak of photography” (R. Barthes. The essay describes the work of some artists/photographers who have addressed the issue of urban photography. Works in which the figurative and visionary component is based on the interaction of traditional shooting techniques and processes of digital post-production.

  11. Defining and identifying Sleeping Beauties in science

    CERN Document Server

    Ke, Qing; Radicchi, Filippo; Flammini, Alessandro

    2015-01-01

    A Sleeping Beauty (SB) in science refers to a paper whose importance is not recognized for several years after publication. Its citation history exhibits a long hibernation period followed by a sudden spike of popularity. Previous studies suggest a relative scarcity of SBs. The reliability of this conclusion is, however, heavily dependent on identification methods based on arbitrary threshold parameters for sleeping time and number of citations, applied to small or monodisciplinary bibliographic datasets. Here we present a systematic, large-scale, and multidisciplinary analysis of the SB phenomenon in science. We introduce a parameter-free measure that quantifies the extent to which a specific paper can be considered an SB. We apply our method to 22 million scientific papers published in all disciplines of natural and social sciences over a time span longer than a century. Our results reveal that the SB phenomenon is not exceptional. There is a continuous spectrum of delayed recognition where both the hiberna...

  12. The Appreciation of the Beauty in the Film:The Curious Case of Benjamin Button

    Institute of Scientific and Technical Information of China (English)

    李家妍

    2014-01-01

    This paper appreciates the beauty in the film The Curious Case of Benjamin Buttonfrom three perspectives: technological beauty in visual ef-fects of the film; philosophical beauty in language, which is discussed in characters’monologues and dialogues in the film; and the eternal beauty of love, life and death.

  13. The Effects of Novelty and Familiarity on Beauty Perception

    Directory of Open Access Journals (Sweden)

    Hyejeong Jang

    2011-05-01

    Full Text Available In order to investigate how novelty and familiarity affect beauty perception, fractal images were presented five times over 14 weeks. Fractal images are unfamiliar to people, hence used in this study to control their previous experience. a total of 800 fractal images were divided into five groups (160 images X 5 group, and three groups of images were presented to participants each time for five times. The results showed that while beauty perception is decreased until the third exposure, it is increased from third to fifth exposure. These results suggest that a certain level of repeated exposure is necessary for subjects to become familiar, which in turn affect beauty perception.

  14. Can we measure beauty? Computational evaluation of coral reef aesthetics

    NARCIS (Netherlands)

    Haas, A.F.; Guibert, M.; Foerschner, A.; Co, T.; Calhoun, S.; George, E.; Hatay, M.; Dinsdale, E.; Sandin, S.A.; Smith, J.E.; Vermeij, M.J.A.; Felts, B.; Dustan, P.; Salamon, P.; Rohwer, F.

    2015-01-01

    The natural beauty of coral reefs attracts millions of tourists worldwide resulting in substantial revenues for the adjoining economies. Although their visual appearance is a pivotal factor attracting humans to coral reefs current monitoring protocols exclusively target biogeochemical parameters, ne

  15. Measurement of beauty production from dimuon events at HERA

    CERN Document Server

    Chekanov, S; Magill, S; Musgrave, B; Nicholass, D; Repond, J; Yoshida, R; Mattingly, M C K; Antonioli, P; Bari, G; Bellagamba, L; Boscherini, D; Bruni, A; Bruni, G; Cindolo, F; Corradi, M; Iacobucci, G; Margotti, A; Nania, R; Polini, A; Antonelli, S; Basile, M; Bindi, M; Cifarelli, L; Contin, A; DePasquale, S; Sartorelli, G; Zichichi, A; Bartsch, D; Brock, I; Hartmann, H; Hilger, E; Jakob, H P; Jüngst, M; Nuncio-Quiroz, A E; Paul, E; Samson, U; Schonberg, V; Shehzadi, R; Wlasenko, M; Brook, N H; Heath, G P; Morris, J D; Kaur, M; Kaur, P; Singh, I; Capua, M; Fazio, S; Mastroberardino, A; Schioppa, M; Susinno, G; Tassi, E; Kim, J Y; Ibrahim, Z A; Kamaluddin, B; WanAbdullah, W A T; Ning, Y; Ren, Z; Sciulli, F; Chwastowski, J; Eskreys, A; Figiel, J; Galas, A; Olkiewicz, K; Stopa, P; Zawiejski, L; Adamczyk, L; Bold, T; Grabowska-Bold, I; Kisielewska, D; Lukasik, J; Przybycien, M; Suszycki, L; Kotanski, A; Slominski, W; Behnke, O; Behrens, U; Bloch, I; Blohm, C; Bonato, A; Borras, K; Bot, D; Ciesielski, R; Coppola, N; Fang, S; Fourletova, J; Geiser, A; Göttlicher, P; Grebenyuk, J; Gregor, I; Gutsche, O; Haas, T; Hain, W; Huttmann, A; Januschek, F; Kahle, B; Katkov, I; Klein, U; Kötz, U; Kowalski, H; Lisovyi, M; Lobodzinska, E; Löhr, B; Mankel, R; Melzer-Pellmann, I A; Miglioranzi, S; Montanari, A; Namsoo, T; Notz, D; Parenti, A; Rinaldi, L; Roloff, P; Rubinsky, I; Schneekloth, U; Spiridonov, A; Szuba, D; Szuba, J; Theedt, T; Ukleja, J; Wolf, G; Wrona, K; YaguesMolina, A G; Youngman, C; Zeuner, W; Drugakov, V; Lohmann, W; Schlenstedt, S; Barbagli, G; Gallo, E; Pelfer, P G; Bamberger, A; Dobur, D; Karstens, F; Vlasov, N N; Bussey, P J; Doyle, A T; Dunne, W; Forrest, M; Rosin, M; Saxon, D H; Skillicorn, I O; Gialas, I; Papageorgiu, K; Holm, U; Klanner, R; Lohrmann, E; Perrey, H; Schleper, P; Schörner-Sadenius, T; Sztuk, J; Stadie, H; Turcato, M; Foudas, C; Fry, C; Long, K R; Tapper, A D; Matsumoto, T; Nagano, K; Tokushuku, K; Yamada, S; Yamazaki, Y; Barakbaev, A N; Boos, E G; Pokrovskiy, N S; Zhautykov, B O; Aushev, V; Bachynska, O; Borodin, M; Kadenko, I; Kozulia, A; Libov, V; Lontkovskyi, D; Makarenko, I; Sorokin, Iu; Verbytskyi, A; Volynets, O; Son, D; deFavereau, J; Piotrzkowski, K; Barreiro, F; Glasman, C; Jiménez, M; Labarga, L; delPeso, J; Ron, E; Soares, M; Terron, J; Zambrana, M; Corriveau, F; Liu, C; Schwartz, J; Walsh, R; Zhou, C; Tsurugai, T; Antonov, A; Dolgoshein, B A; Gladkov, D; Sosnovtsev, V; Stifutkin, A; Suchkov, S; Dementiev, R K; Ermolov, P F; Gladilin, L K; Golubkov, Yu A; Khein, L A; Korzhavina, I A; Kuzmin, V A; Levchenko, B B; Lukina, O Yu; Proskuryakov, A S; Shcheglova, L M; Zotkin, D S; Abt, I; Caldwell, A; Kollar, D; Reisert, B; Schmidke, W B; Grigorescu, G; Keramidas, A; Koffeman, E; Kooijman, P; Pellegrino, A; Tiecke, H; Vázquez, M; Wiggers, L; Brümmer, N; Bylsma, B; Durkin, L S; Lee, A; Ling, T Y; Allfrey, P D; Bell, M A; Cooper-Sarkar, A M; Devenish, R C E; Ferrando, J; Foster, B; Gwenlan, C; Korcsak-Gorzo, K; Oliver, K; Robertson, A; Uribe-Estrada, C; Walczak, R; Bertolin, A; Dal Corso, F; Dusini, S; Longhin, A; Stanco, L; Bellan, P; Brugnera, R; Carlin, R; Garfagnini, A; Limentani, S; Oh, B Y; Raval, A; Whitmore, J J; Iga, Y; D'Agostini, G; Marini, G; Nigro, A; Cole, J E; Hart, J C; Abramowicz, H; Ingbir, R; Kananov, S; Levy, A; Stern, A; Kuze, M; Maeda, J; Hori, R; Kagawa, S; Okazaki, N; Shimizu, S; Tawara, T; Hamatsu, R; Kaji, H; Kitamura, S; Ota, O; Ri, Y D; Costa, M; Ferrero, M I; Monaco, V; Sacchi, R; Solano, A; Arneodo, M; Ruspa, M; Fourletov, S; Martin, J F; Stewart, T P; Boutle, S K; Butterworth, J M; Jones, T W; Loizides, J H; Wing, M; Brzozowska, B; Ciborowski, J; Grzelak, G; Kulinski, P; Luzniak, P; Malka, J; Nowak, R J; Pawlak, J M; Perlanski, W; Tymieniecka, T; Zarnecki, A F; Adamus, M; Plucinsky, P P; Ukleja, A; Eisenberg, Y; Hochman, D; Karshon, U; Brownson, E; Reeder, D D; Savin, A A; Smith, W H; Wolfe, H; Bhadra, S; Catterall, C D; Cui, Y; Hartner, G; Menary, S; Noor, U; Standage, J; Whyte, J

    2009-01-01

    Beauty production in events containing two muons in the final state has been measured with the ZEUS detector at HERA using an integrated luminosity of 114 pb-1. A low transverse-momentum threshold for muon identification, in combination with the large rapidity coverage of the ZEUS muon system, gives access to almost the full phase space for beauty production. The total cross section for beauty production in ep collisions at sqrt(s)= 318 GeV has been measured to be sigma_tot(ep -> bbbar X) = 13.9 +- 1.5(stat.) +4.0 -4.3(syst.) nb. Differential cross sections and a measurement of bbbar correlations are also obtained, and compared to other beauty cross-section measurements, Monte Carlo models and next-to-leading-order QCD predictions.

  16. Isovector and hidden-beauty partners of the X(3872)

    Energy Technology Data Exchange (ETDEWEB)

    Høgaasen, Hallstein, E-mail: hallstein.hogasen@fys.uio.no [Department of Physics, University of Oslo, Box 1048, NO-0316 Oslo (Norway); Kou, Emi, E-mail: kou@lal.in2p3.fr [Laboratoire de l' Accélérateur Linéaire, Université Paris-Sud, IN2P3-CNRS, Centre Scientifique d' Orsay, 91898 Orsay Cedex (France); Richard, Jean-Marc, E-mail: j-m.richard@ipnl.in2p3.fr [Université de Lyon, Institut de Physique Nucléaire de Lyon, UCBL–IN2P3-CNRS, 4, rue Enrico Fermi, 69622 Villeurbanne Cedex (France); Sorba, Paul, E-mail: paul.sorba@lapth.cnrs.fr [LAPTh, Laboratoire d' Annecy-le-Vieux de Physique Théorique, CNRS, Université de Savoie, BP 110, 74941 Annecy-le-Vieux Cedex (France)

    2014-05-01

    The isovector partners of the X(3872), recently found at BES III, Belle and CLEO-c were predicted in a simple model based on the chromomagnetic interaction among quarks. The extension to the hidden-beauty sector is discussed.

  17. Measurement of beauty production in DIS and extraction at ZEUS

    Energy Technology Data Exchange (ETDEWEB)

    Abramowicz, H.; Ingbir, R.; Kananov, S.; Levy, A.; Stern, A. [Tel Aviv University, Raymond and Beverly Sackler Faculty of Exact Sciences, School of Physics, Tel Aviv (Israel); Abt, I.; Caldwell, A.; Kollar, D.; Reisert, B.; Schmidke, W.B. [Max-Planck-Institut fuer Physik, Muenchen (Germany); Adamczyk, L.; Bold, T.; Gach, G.; Grabowska-Bold, I.; Kisielewska, D.; Przybycien, M.; Suszycki, L. [AGH-University of Science and Technology, Faculty of Physics and Applied Computer Science, Cracow (Poland); Adamus, M.; Plucinski, P.; Tymieniecka, T. [Institute for Nuclear Studies, Warsaw (Poland); Aggarwal, R.; Kaur, M.; Kaur, P.; Singh, I. [Panjab University, Department of Physics, Chandigarh (India); Antonelli, S.; Basile, M.; Bindi, M.; Cifarelli, L.; Contin, A.; De Pasquale, S.; Sartorelli, G.; Zichichi, A. [University Bologna (Italy); INFN Bologna, Bologna (Italy); Antonioli, P.; Bari, G.; Bellagamba, L.; Boscherini, D.; Bruni, A.; Bruni, G.; Cindolo, F.; Corradi, M.; Iacobucci, G.; Margotti, A.; Nania, R.; Polini, A. [INFN Bologna, Bologna (Italy); Antonov, A.; Dolgoshein, B.A.; Gladkov, D.; Sosnovtsev, V.; Stifutkin, A.; Suchkov, S. [Moscow Engineering Physics Institute, Moscow (Russian Federation); Arneodo, M.; Ruspa, M. [Universita del Piemonte Orientale, Novara (Italy); INFN, Torino (Italy); Aushev, V.; Aushev, Y.; Borodin, M.; Gogota, O.; Kadenko, I.; Korol, I.; Kuprash, O.; Lontkovskyi, D.; Makarenko, I.; Onishchuk, Yu.; Salii, A.; Tomalak, O.; Viazlo, V.; Volynets, O.; Zenaiev, O.; Zhmak, N.; Zolko, M. [National Academy of Sciences, and Kiev National University, Institute for Nuclear Research, Kiev (Ukraine); Bachynska, O.; Behnke, O.; Behr, J.; Behrens, U.; Blohm, C.; Borras, K.; Bot, D.; Ciesielski, R.; Coppola, N.; Fang, S.; Geiser, A.; Goettlicher, P.; Grebenyuk, J.; Gregor, I.; Haas, T.; Hain, W.; Huettmann, A.; Januschek, F.; Kahle, B.; Katkov, I.I.; Klein, U.; Koetz, U.; Kowalski, H.; Libov, V.; Lisovyi, M.; Lobodzinska, E. [and others

    2010-10-15

    Beauty production in deep inelastic scattering with events in which a muon and a jet are observed in the final state has been measured with the ZEUS detector at HERA using an integrated luminosity of 114 pb{sup -1}. The fraction of events with beauty quarks in the data was determined using the distribution of the transverse momentum of the muon relative to the jet. The cross section for beauty production was measured in the kinematic range of photon virtuality, Q{sup 2}>2 GeV{sup 2}, and inelasticity, 0.05beauty contribution to the structure function F{sub 2} was extracted and is compared to theoretical predictions. (orig.)

  18. Sunflower Beauty Contest : tsvetõ zimoi / Marina Poltavtseva

    Index Scriptorium Estoniae

    Poltavtseva, Marina

    2001-01-01

    Lillekleitide võistlusest Sunflower Beauty Contest Tallinna klubis Decolte. Konkursi idee on florist Tatjana Tridvornovalt. Esimese koha sai Viimsi lilleäri lilleseadjate Meri-Liis Kõivu ja Triinu Põlderi lillekleit "Talvepruut"

  19. Trinity and beauty: The theological contribution of Jonathan Edwards

    Directory of Open Access Journals (Sweden)

    R. Venter

    2012-02-01

    Full Text Available The article explores the relationship between the trinitarian confession of God and beauty. Special attention is paid to Jonathan Edwards, the eighteenth-centur ypreacher and thinker, who in an exceptional manner viewed God in terms of beauty. The discussion is located in the context of a vigorous international Edwardsian scholarship on metaphysics, the nature of God and aesthetics. The article points out that beauty, according to Edwards, is primarily relational. The article aims at contributing to two neglected scholarly areas – the treatment of the doctrine of God in aesthetic terms, and the study of Jonathan Edwards in a South African context. Areas for further reflection are also identified. The article intimates that a discussion about trinity and beauty may have social ramifications.

  20. Measurement of beauty production from dimuon events at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Chekanov, S.; Derrick, M.; Magill, S. [Argonne National Laboratory, Argonne, IL (United States)] (and others)

    2008-09-15

    Beauty production in events containing two muons in the final state has been measured with the ZEUS detector at HERA using an integrated luminosity of 114 pb{sup -1}. A low transverse-momentum threshold for muon identification, in combination with the large rapidity coverage of the ZEUS muon system, gives access to almost the full phase space for beauty production. The total cross section for beauty production in ep collisions at {radical}(s) = 318 GeV has been measured to be {sigma}{sub tot}(ep {yields} b anti bX) = 13.9 {+-} 1.5(stat.){sub -4.3}{sup +4.0}(syst.) nb. Differential cross sections and a measurement of b anti b correlations are also obtained, and compared to other beauty cross-section measurements, Monte Carlo models and next-to-leading-order QCD predictions. (orig.)

  1. Toward Constructing the Therapeutic System.

    Science.gov (United States)

    Andolfi, Maurizio; Angelo, Claudio

    1988-01-01

    Describes the therapist as an active participant in the construction of the therapeutic system, explaining how the therapist constructs complex relationships within the evolving therapeutic process. Reevaluates the importance of the individual in the family as an agent of change and as a mediator of triangular relational messages. (Author/NB)

  2. The Effects of Novelty and Familiarity on Beauty Perception

    OpenAIRE

    Hyejeong Jang; Han Nim Cha; Woo Hyun Jung

    2011-01-01

    In order to investigate how novelty and familiarity affect beauty perception, fractal images were presented five times over 14 weeks. Fractal images are unfamiliar to people, hence used in this study to control their previous experience. a total of 800 fractal images were divided into five groups (160 images X 5 group), and three groups of images were presented to participants each time for five times. The results showed that while beauty perception is decreased until the third exposure, it i...

  3. The experience of mathematical beauty and its neural correlates.

    OpenAIRE

    Semir eZeki; John Paul Romaya; Benincasa, Dionigi M. T.; Atiyah, Michael F.

    2014-01-01

    Many have written of the experience of mathematical beauty as being comparable to that derived from the greatest art. This makes it interesting to learn whether the experience of beauty derived from such a highly intellectual and abstract source such as mathematics correlates with activity in the same part of the emotional brain as that derived from more sensory, perceptually based, sources. To determine this, we used functional magnetic resonance imaging (fMRI) to image the activity in the b...

  4. Toward a brain-based theory of beauty.

    Science.gov (United States)

    Ishizu, Tomohiro; Zeki, Semir

    2011-01-01

    We wanted to learn whether activity in the same area(s) of the brain correlate with the experience of beauty derived from different sources. 21 subjects took part in a brain-scanning experiment using functional magnetic resonance imaging. Prior to the experiment, they viewed pictures of paintings and listened to musical excerpts, both of which they rated on a scale of 1-9, with 9 being the most beautiful. This allowed us to select three sets of stimuli--beautiful, indifferent and ugly--which subjects viewed and heard in the scanner, and rated at the end of each presentation. The results of a conjunction analysis of brain activity showed that, of the several areas that were active with each type of stimulus, only one cortical area, located in the medial orbito-frontal cortex (mOFC), was active during the experience of musical and visual beauty, with the activity produced by the experience of beauty derived from either source overlapping almost completely within it. The strength of activation in this part of the mOFC was proportional to the strength of the declared intensity of the experience of beauty. We conclude that, as far as activity in the brain is concerned, there is a faculty of beauty that is not dependent on the modality through which it is conveyed but which can be activated by at least two sources--musical and visual--and probably by other sources as well. This has led us to formulate a brain-based theory of beauty.

  5. A beautiful question finding nature’s deep design

    CERN Document Server

    Wilczek, Frank

    2015-01-01

    Artists as well as scientists throughout human history have pondered this “beautiful question.” With Nobel laureate Frank Wilczek as your guide, embark on a voyage of related discoveries, from Plato and Pythagoras up to the present. Wilczek’s groundbreaking work in quantum physics was inspired by his intuition to look for a deeper order of beauty in nature. In fact, every major advance in his career came from this intuition: to assume that the universe embodies beautiful forms, forms whose hallmarks are symmetry—harmony, balance, proportion—and economy. There are other meanings of “beauty,” but this is the deep logic of the universe—and it is no accident that it is also at the heart of what we find aesthetically pleasing and inspiring. Wilczek is hardly alone among great scientists in charting his course using beauty as his compass. As he reveals in A Beautiful Question, this has been the heart of scientific pursuit from Pythagoras, the ancient Greek who was the first to argue that “all thi...

  6. Mathematics make microbes beautiful, beneficial, and bountiful.

    Science.gov (United States)

    Jungck, John R

    2012-01-01

    Microbiology is a rich area for visualizing the importance of mathematics in terms of designing experiments, data mining, testing hypotheses, and visualizing relationships. Historically, Nobel Prizes have acknowledged the close interplay between mathematics and microbiology in such examples as the fluctuation test and mutation rates using Poisson statistics by Luria and Delbrück and the use of graph theory of polyhedra by Caspar and Klug. More and more contemporary microbiology journals feature mathematical models, computational algorithms and heuristics, and multidimensional visualizations. While revolutions in research have driven these initiatives, a commensurate effort needs to be made to incorporate much more mathematics into the professional preparation of microbiologists. In order not to be daunting to many educators, a Bloom-like "Taxonomy of Quantitative Reasoning" is shared with explicit examples of microbiological activities for engaging students in (a) counting, measuring, calculating using image analysis of bacterial colonies and viral infections on variegated leaves, measurement of fractal dimensions of beautiful colony morphologies, and counting vertices, edges, and faces on viral capsids and using graph theory to understand self assembly; (b) graphing, mapping, ordering by applying linear, exponential, and logistic growth models of public health and sanitation problems, revisiting Snow's epidemiological map of cholera with computational geometry, and using interval graphs to do complementation mapping, deletion mapping, food webs, and microarray heatmaps; (c) problem solving by doing gene mapping and experimental design, and applying Boolean algebra to gene regulation of operons; (d) analysis of the "Bacterial Bonanza" of microbial sequence and genomic data using bioinformatics and phylogenetics; (e) hypothesis testing-again with phylogenetic trees and use of Poisson statistics and the Luria-Delbrück fluctuation test; and (f) modeling of

  7. Antibody-mediated phagocytosis contributes to the anti-tumor activity of the therapeutic antibody daratumumab in lymphoma and multiple myeloma

    DEFF Research Database (Denmark)

    Overdijk, M. B.; Verploegen, S.; Bogels, M.

    2015-01-01

    and an intravenous leukemic xenograft mouse model. Finally, DARA was shown to induce macrophage-mediated phagocytosis of MM cells isolated from 11 of 12MM patients that showed variable levels of CD38 expression. In summary, we demonstrate that phagocytosis is a fast, potent and clinically relevant mechanism...... in MM and other hematological tumors, led us to investigate the contribution of antibody-dependent, macrophage-mediated phagocytosis to DARA's mechanism of action. Live cell imaging revealed that DARA efficiently induced macrophage-mediated phagocytosis, in which individual macrophages rapidly...... and sequentially engulfed multiple tumor cells. DARA-dependent phagocytosis by mouse and human macrophages was also observed in an in vitro flow cytometry assay, using a range of MM and Burkitt's lymphoma cell lines. Phagocytosis contributed to DARA's anti-tumor activity in vivo, in both a subcutaneous...

  8. To Know the beauty of Xishi Culture Hometown of Ancient Beauty Xishi

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    <正> The scenic area of Beauty Xishi’s hometown relies on the Xishi culture as the theme, and it shows the ancient Yue State Culture. It hasnatural landscape, abundant culture sediment, complete tourism establishment and modern energy. There are more than 150 scenicspots, its representative scenic spot is Huanjiang. Wuxie, the national key scenic spot in Xishi’s hometown, including Wuxie, Douyan andTangjiangyan, where have unique value to appreciate and taste, enjoys great popularity in china and abroad, and becomes the state-levelscenic spot of landscape.

  9. Becoming Beautifully Modern: An Ethnographic Study of the Work of Beauty Amongst British Pakistani women in Sheffield

    OpenAIRE

    Clarke, Hester Frances

    2016-01-01

    My research explores the tension between being and becoming modern and moral for British-born Muslim Pakistani women in Sheffield through an investigation into the judgements that surround beauty, beautification, and beauty work. Through ethnography I unpack the raced and classed regimes in which my interlocutors are embedded, arguing that global Islam and Asian are affiliations that are realised in relation to the English (White British) community. Through comparisons to White British women ...

  10. Academic Training: Small may be beautiful

    CERN Multimedia

    Françoise Benz

    2005-01-01

    2004-2005 ACADEMIC TRAINING PROGRAMME LECTURE SERIES 13, 14, 15, 16 and 17 June 13, 14, 16, 17 June from 11:00 to 12:00, 15 June from 10:00 to 12:00 - Auditorium, bldg. 500 Small may be beautiful M. DAVIER / LAL, Orsay, France and T. SOLDNER / ILL, Grenoble, France M. DAVIER 13, 14, 15 June Besides the direct high-energy approach, particle physics frontiers can be explored by low-energy high-sensitivity experiments. These experiments, small on the scale of LHC detectors, can be very effective in reaching a sensitivity level why physics beyond the Standard Model can contribute. In these lectures we will discuss a subject of such experiments (excluding cold neutrons covered in T. Soldner's lectures), their interplay with theory and their impact on our knowledge of new phenomena : anormalous magnetic moments of leptons, weak-electromagnetic interference at low energy and in atomic physics, searches for an electron electric dipole moment in atomic and molecular physics. T. SOLDNER 15, 16, 17 June Neutron pa...

  11. Sleeping Beauty transposition: from biology to applications.

    Science.gov (United States)

    Narayanavari, Suneel A; Chilkunda, Shreevathsa S; Ivics, Zoltán; Izsvák, Zsuzsanna

    2017-02-01

    Sleeping Beauty (SB) is the first synthetic DNA transposon that was shown to be active in a wide variety of species. Here, we review studies from the last two decades addressing both basic biology and applications of this transposon. We discuss how host-transposon interaction modulates transposition at different steps of the transposition reaction. We also discuss how the transposon was translated for gene delivery and gene discovery purposes. We critically review the system in clinical, pre-clinical and non-clinical settings as a non-viral gene delivery tool in comparison with viral technologies. We also discuss emerging SB-based hybrid vectors aimed at combining the attractive safety features of the transposon with effective viral delivery. The success of the SB-based technology can be fundamentally attributed to being able to insert fairly randomly into genomic regions that allow stable long-term expression of the delivered transgene cassette. SB has emerged as an efficient and economical toolkit for safe and efficient gene delivery for medical applications.

  12. Sleeping Beauty: Kleine–Levin Syndrome

    Science.gov (United States)

    Mudgal, Soumiya; Jiloha, R. C.; Kandpal, Manish; Das, Aparna

    2014-01-01

    Kleine–Levin syndrome (KLS) alias sleeping beauty syndrome, is a rare sleep disorder. Clinically presenting as episodes of hypersomnolence, behavioral and cognitive disturbances, hyperphagia and hypersexuality. KLS may have an idiopathic onset or may be precipitated by neurological event or infection. Until date, no definite underlying cause is established and neither there are any definitive management guidelines. It remains a diagnosis of exclusion after other psychiatric and neurological causes have been ruled out. Coloring of presentation with behavioral and mood elements makes it important for a psychiatrist to be well-informed about the condition to avoid the erroneous diagnosis. KLS is a devastating illness, which robs the patient of time, experiences, and relationships. An early diagnosis and effective management can help patient escape from the morbidity caused by this disorder. Armodafinil and oxcarbamazepine have found to be effective in two of the case. The emphasis of this report is to add to the existing clinical knowledge of neurologists, psychiatrists and physicians. In the future, research is needed on genetic etiology and management of this disorder. PMID:25316944

  13. Like Beauty, Complexity is Hard to Define

    Science.gov (United States)

    Tsallis, Constantino

    Like beauty, complexity is hard to define and rather easy to identify: nonlinear dynamics, strongly interconnected simple elements, some sort of divisoria aquorum between order and disorder. Before focusing on complexity, let us remember that the theoretical pillars of contemporary physics are mechanics (Newtonian, relativistic, quantum), Maxwell electromagnetism, and (Boltzmann-Gibbs, BG) statistical mechanics - obligatory basic disciplines in any advanced course in physics. The firstprinciple statistical-mechanical approach starts from (microscopic) electro-mechanics and theory of probabilities, and, through a variety of possible mesoscopic descriptions, arrives to (oscopic) thermodynamics. In the middle of this trip, we cross energy and entropy. Energy is related to the possible microscopic configurations of the system, whereas entropy is related to the corresponding probabilities. Therefore, in some sense, entropy represents a concept which, epistemologically speaking, is one step further with regard to energy. The fact that energy is not parameter-independent is very familiar: the kinetic energy of a truck is very different from that of a fly, and the relativistic energy of a fast electron is very different from its classical value, and so on. What about entropy? One hundred and forty years of tradition, and hundreds - we may even say thousands - of impressive theoretical successes of the parameter-free BG entropy have sedimented, in the mind of many scientists, the conviction that it is unique. However, it can be straightforwardly argued that, in general, this is not the case...

  14. The 2016 interferometric imaging beauty contest

    Science.gov (United States)

    Sanchez-Bermudez, J.; Thiébaut, E.; Hofmann, K.-H.; Heininger, M.; Schertl, D.; Weigelt, G.; Millour, F.; Schutz, A.; Ferrari, A.; Vannier, M.; Mary, D.; Young, J.

    2016-08-01

    Image reconstruction in optical interferometry has gained considerable importance for astrophysical studies during the last decade. This has been mainly due to improvements in the imaging capabilities of existing interferometers and the expectation of new facilities in the coming years. However, despite the advances made so far, image synthesis in optical interferometry is still an open field of research. Since 2004, the community has organized a biennial contest to formally test the different methods and algorithms for image reconstruction. In 2016, we celebrated the 7th edition of the "Interferometric Imaging Beauty Contest". This initiative represented an open call to participate in the reconstruction of a selected set of simulated targets with a wavelength-dependent morphology as they could be observed by the 2nd generation of VLTI instruments. This contest represents a unique opportunity to benchmark, in a systematic way, the current advances and limitations in the field, as well as to discuss possible future approaches. In this contribution, we summarize: (a) the rules of the 2016 contest; (b) the different data sets used and the selection procedure; (c) the methods and results obtained by each one of the participants; and (d) the metric used to select the best reconstructed images. Finally, we named Karl-Heinz Hofmann and the group of the Max-Planck-Institut f ur Radioastronomie as winners of this edition of the contest.

  15. Artists with Arthritis Create Beauty amid Pain

    Institute of Scientific and Technical Information of China (English)

    Alan; Mozes; 蔡峥伟

    2000-01-01

    得此来稿,我们曾犹豫再三,是否刊用此文。因为,其内容给人的第一印象颇有点离奇。Artists with Arthritis Create Beauty amid Pain,怎么可能呢?细读之下,你也许会觉得,此文虽是一家之言,但也并非荒唐。尤其是本文的收尾句,笔锋一转,抖出了妙言: ...in addition to the emotional support such stories can give RA patients,there are now new drug options that far surpass the treatment choices Renoir faced. 此句是否可译:除了此类故事能够给患风湿病者一种情感上的支持之外,现在可选的新药要比Renoir(雷诺阿,法国印象派画家。主要作品有《包厢》、《游船上的午餐》、《浴女》等。)时代强得多。

  16. Unification: Not Just a Thing of Beauty

    Directory of Open Access Journals (Sweden)

    Ioannis Votsis

    2015-03-01

    Full Text Available We often hear that simplicity, explanatory power and unification, though aesthetically pleasing or beautiful qualities, are at best pragmatic considerations in matters of choosing between rival hypotheses. This paper aims to offer a novel conception and an associated measure of unification, both of which are demonstrably more than just pragmatic considerations. The discussion departs from a brief survey of some failed attempts to carve out adequate conceptions of unification. It then proceeds to an analysis of the notions of confirmational connectedness and disconnectedness. Roughly speaking, these notions attempt to capture the way support propagates or fails to propagate between the content parts of a hypothesis or, equivalently, between the contents of two or more hypotheses. The two notions are instrumental in helping to tackle the problem of ad hoc, and in particular monstrous, hypotheses. More importantly for the purposes of this paper, they are essential ingredients in the proposed conception of unification and its associated measure. In simple terms, the more the content of a hypothesis (or, equivalently, the content of a set of hypotheses is confirmationally connected the more that content is unified. Since the confirmational connectedness of two content parts is determined by purely objective matters of fact, the proposed notion and measure of unification are themselves strictly objective, i.e. not merely pragmatic considerations in matters of hypothesis choice. The paper concludes with a discussion of how the proposed measure handles real and hypothetical examples but also how it stands up to various objections.

  17. Evaluation of Facial Beauty Using Anthropometric Proportions

    Directory of Open Access Journals (Sweden)

    Jovana Milutinovic

    2014-01-01

    Full Text Available The improvement of a patient’s facial appearance is one of the main goals of contemporary orthodontic treatment. The aim of this investigation was to evaluate the difference in facial proportions between attractive and anonymous females in order to establish objective facial features which are widely considered as beautiful. The study included two groups: first group consisted of 83 Caucasian female subjects between 22 and 28 years of age who were selected from the population of students at the University of Belgrade, and the second group included 24 attractive celebrity Caucasian females. The en face facial photographs were taken in natural head position (NHP. Numerous parameters were recorded on these photographs, in order to establish facial symmetry and correlation with the ideal set of proportions. This study showed significant difference between anonymous and attractive females. Attractive females showed smaller face in general and uniformity of the facial thirds and fifths, and most of the facial parameters meet the criteria of the ideal proportions.

  18. Reprogramming of Human Fibroblasts to Induced Pluripotent Stem Cells with Sleeping Beauty Transposon-Based Stable Gene Delivery.

    Science.gov (United States)

    Sebe, Attila; Ivics, Zoltán

    2016-01-01

    Human induced pluripotent stem (iPS) cells are a source of patient-specific pluripotent stem cells and resemble human embryonic stem (ES) cells in gene expression profiles, morphology, pluripotency, and in vitro differentiation potential. iPS cells are applied in disease modeling, drug screenings, toxicology screenings, and autologous cell therapy. In this protocol, we describe how to derive human iPS cells from fibroblasts by Sleeping Beauty (SB) transposon-mediated gene transfer of reprogramming factors. First, the components of the non-viral Sleeping Beauty transposon system, namely a transposon vector encoding reprogramming transcription factors and a helper plasmid expressing the SB transposase, are electroporated into human fibroblasts. The reprogramming cassette undergoes transposition from the transfected plasmids into the fibroblast genome, thereby resulting in stable delivery of the reprogramming factors. Reprogramming by using this protocol takes ~4 weeks, after which the iPS cells are isolated and clonally propagated.

  19. ISLAMIC BEAUTY: Socio-Semiotic Analysis of Facial Foam and Body Lotion Advertisement

    Directory of Open Access Journals (Sweden)

    Susi Herti Afriani

    2012-12-01

    Full Text Available This paper attempts to answer how Islamic Women define the concept of beauty in Ponds advertisement white beauty facial foam and body lotion on television. This study uses a socio-semiotic approach described through three aspects of social context, namely field, tenor, and mode. It argues that Ponds’ definition of a beauty only refers to physical standards, that is, women who have white skin and use both Ponds White Beauty Facial Foam and Foam Body Lotion. Further, television through Ponds advertising is considered as a commercial institution that supports the main idea of capitalism. However, Islamic women consider beautiful physically and spiritually. It suggests that the beautiful women are those who obey and surrender to Allah SWT. In short, Islamic women do not agree with the meaning of beauty resulted from Ponds White Beauty Facial Foam and Ponds Body Lotion advertisement. Rather, beauty consists of both body and, more importantly, soul.

  20. Reactive oxygen species induced by therapeutic CD20 antibodies inhibit natural killer cell-mediated antibody-dependent cellular cytotoxicity against primary CLL cells

    Science.gov (United States)

    Werlenius, Olle; Aurelius, Johan; Hallner, Alexander; Akhiani, Ali A.; Simpanen, Maria; Martner, Anna; Andersson, Per-Ola; Hellstrand, Kristoffer; Thorén, Fredrik B.

    2016-01-01

    The antibody-dependent cellular cytotoxicity (ADCC) of natural killer (NK) cells is assumed to contribute to the clinical efficacy of monoclonal antibodies (mAbs) in chronic lymphocytic leukemia (CLL) and other hematopoietic malignancies of B cell origin. We sought to determine whether reactive oxygen species (ROS)-producing monocytes regulate the ADCC of NK cells against primary CLL cells using anti-CD20 as the linking antibody. The monoclonal CD20 antibodies rituximab and ofatumumab were found to trigger substantial release of ROS from monocytes. Antibody-exposed monocytes induced NK cell apoptosis and restricted NK cell-mediated ADCC against autologous CLL cells. The presence of inhibitors of ROS formation and scavengers of ROS preserved NK cell viability and restored NK cell-mediated ADCC against primary CLL cells. We propose that limiting the antibody-induced induction of immunosuppressive ROS may improve the anti-leukemic efficacy of anti-CD20 therapy in CLL. PMID:27097113

  1. Functional Validation of H2 Relaxin, and its Downstream Effectors, as Mediators, Therapeutic Targets and Potential Biomarkers of Prostate Cancer Progression

    Science.gov (United States)

    2011-06-01

    Endocr Rev 2004; 25: 205-34. 20. Samuel CS, Tian H, Zhao L, Amento EP. Relaxin is a key mediator of prostate growth and male reproductive tract...Prostatic Dis 2005; 8: 119-26. 31. Bathgate RA, Samuel CS, Burazin TC, Gundlach AL, Tregear GW. Relaxin: new peptides, receptors and novel actions...R, Beckett LA, Deitch AD, de Vere White RW. (2004). A modified yeast assay used on archival samples of localized prostate cancer tissue improves the

  2. Charm and Beauty Production from Secondary Vertexing at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Thompson, Paul [University of Birmingham, Edgbaston, Birmingham, B15 2TT (United Kingdom)

    2010-07-01

    Measurement of the Charm and Beauty Structure Functions using the H1 Vertex Detector at HERA Inclusive charm and beauty cross sections are measured in e{sup -} p and e{sup +}p neutral current collisions at HERA in the kinematic region of photon virtuality 5 < Q{sup 2} < 2000 GeV{sup 2} and Bjorken scaling variable 0.0002 < x < 0.05. The data were collected with the H1 detector in the years 2006 and 2007 corresponding to an integrated luminosity of 189 pb{sup -1}. The numbers of charm and beauty events are determined using variables reconstructed by the H1 vertex detector including the impact parameter of tracks to the primary vertex and the position of the secondary vertex. The measurements are combined with previous data and compared to QCD predictions. Measurement of Charm and Beauty Jets in Deep Inelastic Scattering at HERA Measurements of the charm and beauty jet cross sections have been made in deep inelastic scattering at HERA for the kinematic region of photon virtuality Q{sup 2} > 6 GeV{sup 2} and elasticity variable 0.07 < y < 0.625 for jets in the laboratory frame with transverse energy E{sub T}{sup jet} > 6 GeV and pseudorapidity -1.0 < {eta}{sup jet} < 1.5. Measurements are also made requiring a jet in the Breit frame with E{sub T}{sup jet} > 6 GeV. The data were collected with the H1 detector in the years 2006 and 2007 corresponding to an integrated luminosity of 189 pb{sup -1}. The number of charm and beauty jets are determined using variables reconstructed by the H1 vertex detector including the impact parameter of tracks to the primary vertex and the position of the secondary vertex. The measurements are compared with QCD predictions and with previous measurements obtained using muon tagging. Charm and beauty production in deep inelastic scattering from inclusive secondary vertexing at ZEUS Charm and beauty production in deep inelastic scattering has been measured with the ZEUS detector using the full HERA II data set. The charm and beauty contents

  3. Can We Model the Scenic Beauty of an Alpine Landscape?

    Directory of Open Access Journals (Sweden)

    Erich Tasser

    2013-03-01

    Full Text Available During the last decade, agriculture has lost its importance in many European mountain regions and tourism, which benefits from attractive landscapes, has become a major source of income. Changes in landscape patterns and elements might affect scenic beauty and therefore the socio-economic welfare of a region. Our study aimed at modeling scenic beauty by quantifying the influence of landscape elements and patterns in relationship to distance. Focusing on Alpine landscapes in South and North Tyrol, we used a photographic questionnaire showing different landscape compositions. As mountain landscapes offer long vistas, we related scenic beauty to different distance zones. Our results indicate that the near zone contributes by 64% to the valuation of scenic beauty, the middle zone by 22%, and the far zone by 14%. In contrast to artificial elements, naturalness and diversity increased scenic beauty. Significant differences between different social groups (origin, age, gender, cultural background occurred only between the local population and tourists regarding great landscape changes. Changes towards more homogenous landscapes were perceived negatively, thus political decision makers should support the conservation of the cultural landscape.

  4. Introducing a "Balance" in The BSC Through Beauty and Love

    Directory of Open Access Journals (Sweden)

    Ari Kamayanti

    2010-04-01

    Full Text Available Celebrating the seventeenth anniversary of the Balanced Score Card (BSC since it was born in 1992, this paper revisits its concept as one of the landmarks in performance measurement. The BSC turns out to be ‘not so balanced’ since it lacks certain beauty and love. It hinges on accountability for certain interests when measuring performance, negating or putting other interests as minority. Thus, it fits perfectly with the aim of management accounting that puts managers and customers as priorities. The imbalances comes from secularism and overemphasis in rationalism. Sustainability that becomes the current issue nowadays would not be supported by such performance measurement. In order to insert this balance, a methodology by taking a methapor of nurturing mother is applied in this research that encompasses gentle beauty and subtle love. Gentle beauty refers to a complete harmony of beauty : irrational and the rational; this means introducing those that have been left out in the name of rationality such as religions and spiritualism. Subtle love refers to love towards God that is expressed subtly without lust to overpower. The result is a more balanced set of performance measurements that are filled with beauty and love, insyaAllah.

  5. The effects of atmospheric optical conditions on perceived scenic beauty

    Science.gov (United States)

    Latimer, Douglas A.; Hogo, Henry; Daniel, Terry C.

    This paper describes the results from the first year of a currently on-going study, the objective of which is to investigate the relationships between atmospheric optical conditions and human perceptions of scenic beauty. Color photographs and atmospheric optical measurements, using telephotometers and nephelometers, were taken in the western U.S.A. (Grand Canyon National Park and Mt. Lemmon near Tucson, Arizona) and in the eastern United States (Great Smoky Mountains and Shenandoah national parks). Over 1300 individual observers rated color slides for either visual air quality or scenic beauty using a 10-point rating scale. Ratings were transformed to indices using standard psychophysical techniques. Relationships between these perceptual indices and physical parameters characteristic of the given landscape represented in the color slides were investigated using scatter plots, correlation analysis, and multiple linear regression. Physical parameters included visual range, horizon sky chromaticity and luminance, solar zenith and scattering angles, and cloud conditions. Results show that observers' ratings of visual air quality and scenic beauty are sensitive to visual range, sky color, and scattering angle. However, in some of the areas investigated, scenic beauty ratings were not affected by changes in visual range. The sensitivity of the scenic beauty of a vista to changes in the extinction coefficient may be useful for establishing visibility goals and priorities.

  6. Assessing a peptidylic inhibitor-based therapeutic approach that simultaneously suppresses polyglutamine RNA- and protein-mediated toxicities in patient cells and Drosophila

    Directory of Open Access Journals (Sweden)

    Qian Zhang

    2016-03-01

    Full Text Available Polyglutamine (polyQ diseases represent a group of progressive neurodegenerative disorders that are caused by abnormal expansion of CAG triplet nucleotides in disease genes. Recent evidence indicates that not only mutant polyQ proteins, but also their corresponding mutant RNAs, contribute to the pathogenesis of polyQ diseases. Here, we describe the identification of a 13-amino-acid peptide, P3, which binds directly and preferentially to long-CAG RNA within the pathogenic range. When administered to cell and Drosophila disease models, as well as to patient-derived fibroblasts, P3 inhibited expanded-CAG-RNA-induced nucleolar stress and suppressed neurotoxicity. We further examined the combined therapeutic effect of P3 and polyQ-binding peptide 1 (QBP1, a well-characterized polyQ protein toxicity inhibitor, on neurodegeneration. When P3 and QBP1 were co-administered to disease models, both RNA and protein toxicities were effectively mitigated, resulting in a notable improvement of neurotoxicity suppression compared with the P3 and QBP1 single-treatment controls. Our findings indicate that targeting toxic RNAs and/or simultaneous targeting of toxic RNAs and their corresponding proteins could open up a new therapeutic strategy for treating polyQ degeneration.

  7. Monocytes-derived macrophages mediated stable expression of human brain-derived neurotrophic factor, a novel therapeutic strategy for neuroAIDS.

    Directory of Open Access Journals (Sweden)

    Jing Tong

    Full Text Available HIV-1 associated dementia remains a significant public health burden. Clinical and experimental research has shown that reduced levels of brain-derived neurotrophic factor (BDNF may be a risk factor for neurological complications associated with HIV-1 infection. We are actively testing genetically modified macrophages for their possible use as the cell-based gene delivery vehicle for the central nervous system (CNS. It can be an advantage to use the natural homing/migratory properties of monocyte-derived macrophages to deliver potentially neuroprotective BDNF into the CNS, as a non-invasive manner. Lentiviral-mediated gene transfer of human (hBDNF plasmid was constructed and characterized. Defective lentiviral stocks were generated by transient transfection of 293T cells with lentiviral transfer plasmid together with packaging and envelope plasmids. High titer lentiviral vector stocks were harvested and used to transduce human neuronal cell lines, primary cultures of human peripheral mononocyte-derived macrophages (hMDM and murine myeloid monocyte-derived macrophages (mMDM. These transduced cells were tested for hBDNF expression, stability, and neuroprotective activity. The GenomeLab GeXP Genetic Analysis System was used to evaluate transduced cells for any adverse effects by assessing gene profiles of 24 reference genes. High titer vectors were prepared for efficient transduction of neuronal cell lines, hMDM, and mMDM. Stable secretion of high levels of hBDNF was detected in supernatants of transduced cells using western blot and ELISA. The conditioned media containing hBDNF were shown to be protective to neuronal and monocytic cell lines from TNF-α and HIV-1 Tat mediated cytotoxicity. Lentiviral vector-mediated gene transduction of hMDM and mMDM resulted in high-level, stable expression of the neuroprotective factorBDNF in vitro. These findings form the basis for future research on the potential use of BDNF as a novel therapy for neuroAIDS.

  8. Monocytes-derived macrophages mediated stable expression of human brain-derived neurotrophic factor, a novel therapeutic strategy for neuroAIDS.

    Science.gov (United States)

    Tong, Jing; Buch, Shilpa; Yao, Honghong; Wu, Chengxiang; Tong, Hsin-I; Wang, Youwei; Lu, Yuanan

    2014-01-01

    HIV-1 associated dementia remains a significant public health burden. Clinical and experimental research has shown that reduced levels of brain-derived neurotrophic factor (BDNF) may be a risk factor for neurological complications associated with HIV-1 infection. We are actively testing genetically modified macrophages for their possible use as the cell-based gene delivery vehicle for the central nervous system (CNS). It can be an advantage to use the natural homing/migratory properties of monocyte-derived macrophages to deliver potentially neuroprotective BDNF into the CNS, as a non-invasive manner. Lentiviral-mediated gene transfer of human (h)BDNF plasmid was constructed and characterized. Defective lentiviral stocks were generated by transient transfection of 293T cells with lentiviral transfer plasmid together with packaging and envelope plasmids. High titer lentiviral vector stocks were harvested and used to transduce human neuronal cell lines, primary cultures of human peripheral mononocyte-derived macrophages (hMDM) and murine myeloid monocyte-derived macrophages (mMDM). These transduced cells were tested for hBDNF expression, stability, and neuroprotective activity. The GenomeLab GeXP Genetic Analysis System was used to evaluate transduced cells for any adverse effects by assessing gene profiles of 24 reference genes. High titer vectors were prepared for efficient transduction of neuronal cell lines, hMDM, and mMDM. Stable secretion of high levels of hBDNF was detected in supernatants of transduced cells using western blot and ELISA. The conditioned media containing hBDNF were shown to be protective to neuronal and monocytic cell lines from TNF-α and HIV-1 Tat mediated cytotoxicity. Lentiviral vector-mediated gene transduction of hMDM and mMDM resulted in high-level, stable expression of the neuroprotective factorBDNF in vitro. These findings form the basis for future research on the potential use of BDNF as a novel therapy for neuroAIDS.

  9. Specific binding of lacosamide to collapsin response mediator protein 2 (CRMP2) and direct impairment of its canonical function: implications for the therapeutic potential of lacosamide

    OpenAIRE

    Sarah M Wilson; Khanna, Rajesh

    2014-01-01

    The novel anti-epileptic drug lacosamide (LCM; SPM927, Vimpat®) has been heralded as having a dual-mode of action through interactions with both the voltage-gated sodium channel and the neurite outgrowth-promoting collapsin response mediator protein 2 (CRMP2). Lacosamide’s ability to dampen neuronal excitability through the voltage-gated sodium channel likely underlies its efficacy in attenuating the symptoms of epilepsy (i.e. seizures). While the role of CRMP2 in epilepsy has not been well-s...

  10. 数学中的美%The Beauty of Mathematics

    Institute of Scientific and Technical Information of China (English)

    耿朝阳

    2012-01-01

    By understanding and discovering the beauty of mathematics, namely golden number, Pythagorean theorem and wonderful symmetry, students can realize many beautiful things in mathematics and transfer "bald learning" into "happy learning". It can not only edify sentiment, but also feel the beauty of mathematics, thus to motivate students' learning interest.%通过认识发现数学中的美,如:黄金数、勾股定理、美妙的对称等,让学生感悟到数学中有很多美的东西,使学生变“苦学”为“乐学”。这样不仅陶冶了情操,又让学生发现感受到数学的美,从而激发了学生的学习兴趣。

  11. Charm and beauty production from Fermilab experiment 789

    Energy Technology Data Exchange (ETDEWEB)

    Brown, C.N.; Cooper, W.E.; Glass, H.D.; Gounder, K.N.; Mishra, C.S. [Fermi National Accelerator Lab., Batavia, IL (United States); Boissevain, J.; Carey, T.A.; Jansen, D.M.; Jeppesen, R.G.; Kapustinsky, J.S. [Los Alamos National Lab., NM (United States)] [and others

    1994-12-31

    Fermilab E789 is a fixed-target charm and beauty experiment which uses a 2-arm spectrometer outfitted with a silicon vertex detector to look for 2-body decays of charm and beauty. The differential cross section for production and the nuclear dependence of neutral D meson production, and the D{sup 0}/D{sup 0}-bar production asymmetry has been measured. Evidence has been seen for beauty production via the inclusive decay B {yields} J/{psi}X, by observing J/{psi} decays well downstream of the target, and have measured a differential cross section for J/{psi} from b or b-bar for 800 GeV pN collisions. (author). 4 refs., 4 figs.

  12. Predicting beauty: fractal dimension and visual complexity in art.

    Science.gov (United States)

    Forsythe, A; Nadal, M; Sheehy, N; Cela-Conde, C J; Sawey, M

    2011-02-01

    Visual complexity has been known to be a significant predictor of preference for artistic works for some time. The first study reported here examines the extent to which perceived visual complexity in art can be successfully predicted using automated measures of complexity. Contrary to previous findings the most successful predictor of visual complexity was Gif compression. The second study examined the extent to which fractal dimension could account for judgments of perceived beauty. The fractal dimension measure accounts for more of the variance in judgments of perceived beauty in visual art than measures of visual complexity alone, particularly for abstract and natural images. Results also suggest that when colour is removed from an artistic image observers are unable to make meaningful judgments as to its beauty.

  13. The Offence of Beauty in Modern Western Art Music

    Directory of Open Access Journals (Sweden)

    Peter Bannister

    2013-12-01

    Full Text Available In recent decades, beauty has become a largely unfashionable, even offensive notion within art and philosophy. As Eastern Orthodox theologian, David Bentley Hart, has pointed out, this offence has a twofold sense. Firstly, the ‘beautiful’ has been dismissed as philosophically insignificant in comparison to the ‘sublime’ by an intellectual tradition tracing itself back to Immanuel Kant’s Critique of Judgment. Secondly, the making of apparently beautiful art has, especially after the Shoah, frequently been regarded as ethically offensive in the face of suffering in the world. The present essay discusses how these two critiques of the beautiful find themselves reflected in twentieth and twenty-first century musical aesthetics, with particular reference to the writings of Theodor W. Adorno, and asks what solutions have been found by composers of Christian sacred music in the Western tradition confronted by this ‘taboo on beauty’.

  14. Dynamic Behavior of Microbubbles during Long Ultrasound Tone-Burst Excitation: Mechanistic Insights into Ultrasound-Microbubble Mediated Therapeutics Using High-Speed Imaging and Cavitation Detection.

    Science.gov (United States)

    Chen, Xucai; Wang, Jianjun; Pacella, John J; Villanueva, Flordeliza S

    2016-02-01

    Ultrasound (US)-microbubble (MB)-mediated therapies have been found to restore perfusion and enhance drug/gene delivery. On the presumption that MBs do not persist during long US exposure under high acoustic pressures, most schemes use short US pulses when a high US pressure is employed. However, we recently observed an enhanced thrombolytic effect using long US pulses at high acoustic pressures. Therefore, we explored the fate of MBs during long tone-burst exposures (5 ms) at various acoustic pressures and MB concentrations via direct high-speed optical observation and passive cavitation detection. MBs first underwent stable or inertial cavitation depending on the acoustic pressure and then formed gas-filled clusters that continued to oscillate, break up and form new clusters. Cavitation detection confirmed continued, albeit diminishing, acoustic activity throughout the 5-ms US excitation. These data suggest that persisting cavitation activity during long tone bursts may confer additional therapeutic effects.

  15. The Khuner Haus by Adolf Loos - a critical study of beauty and desire

    DEFF Research Database (Denmark)

    Fisker, Anna Marie; Hvejsel, Marie Frier; Møller, Hans Ramsgaard

    is to decipherer the architect Adolf Loos’ work, the Khuner Haus, and we put forth the question; do we in Loos’ architecture and thinking find a “Beauty in spite of Nature” as opposed to a “Beauty within Nature”? And if this is the dispute, how has the existence of beauty been challenged? The point of departure...... for our exploration of critical issues about Beauty is the theories of Adolf Loos and Immanuel Kant. To classify Loos’ two views on beauty, both driven by the desire to create more beautiful, we focus on Kant’s work “The critique of judgment” in order to define beauty or the beautifulness. Can the Khuner...

  16. Beauty in photoproduction at HERA II with the ZEUS detector

    Energy Technology Data Exchange (ETDEWEB)

    Boutle, Sarah

    2010-02-15

    The production of beauty quarks in ep collisions should be accurately calculable in perturbative Quantum Chromodynamics (QCD) since the large mass of the b quark provides a hard scale. Therefore it is interesting to compare such predictions to results using photoproduction events where a low-virtuality photon, emitted by the incoming lepton, collides with a parton from the incoming proton. A measurement of beauty in photoproduction has been made at HERA with the ZEUS detector using an integrated luminosity of 126 pb{sup -}1. Beauty was identified in events with a muon in the final state by using the transverse momentum of the muon relative to the closest jet. Lifetime information from the silicon vertex detector was also used; the impact parameter of the muon with respect to the primary vertex was exploited to discriminate between signal and background. Cross sections for beauty production as a function of the muon and the jet variables were measured and compared to QCD predictions and to previous measurements. The data were found to be well described by the predictions from next-to-leading-order QCD. The dijet sample of beauty photoproduction events was also used to study higher-order QCD topologies. At leading order, the two jets in the event are produced back-to-back in azimuthal angle, such that {delta}{phi}{sup jj}={phi}{sup j1}-{phi}{sup j2}={pi}. Additional soft radiation causes small azimuthal decorrelations, whilst {delta}{phi}{sup jj} significantly lower than {pi} is evidence of additional hard radiation. In this thesis, the cross section versus {delta}{phi}{sup jj} for beauty photoproduction and the comparison to NLO QCD predictions and Monte Carlo models are presented. (orig.)

  17. A New Therapeutic Modality for Acute Myocardial Infarction: Nanoparticle-Mediated Delivery of Pitavastatin Induces Cardioprotection from Ischemia-Reperfusion Injury via Activation of PI3K/Akt Pathway and Anti-Inflammation in a Rat Model.

    Directory of Open Access Journals (Sweden)

    Kazuhiro Nagaoka

    Full Text Available There is an unmet need to develop an innovative cardioprotective modality for acute myocardial infarction (AMI, for which the effectiveness of interventional reperfusion therapy is hampered by myocardial ischemia-reperfusion (IR injury. Pretreatment with statins before ischemia is shown to reduce MI size in animals. However, no benefit was found in animals and patients with AMI when administered at the time of reperfusion, suggesting insufficient drug targeting into the IR myocardium. Here we tested the hypothesis that nanoparticle-mediated targeting of pitavastatin protects the heart from IR injury.In a rat IR model, poly(lactic acid/glycolic acid (PLGA nanoparticle incorporating FITC accumulated in the IR myocardium through enhanced vascular permeability, and in CD11b-positive leukocytes in the IR myocardium and peripheral blood after intravenous treatment. Intravenous treatment with PLGA nanoparticle containing pitavastatin (Pitavastatin-NP, 1 mg/kg at reperfusion reduced MI size after 24 hours and ameliorated left ventricular dysfunction 4-week after reperfusion; by contrast, pitavastatin alone (as high as 10 mg/kg showed no therapeutic effects. The therapeutic effects of Pitavastatin-NP were blunted by a PI3K inhibitor wortmannin, but not by a mitochondrial permeability transition pore inhibitor cyclosporine A. Pitavastatin-NP induced phosphorylation of Akt and GSK3β, and inhibited inflammation and cardiomyocyte apoptosis in the IR myocardium.Nanoparticle-mediated targeting of pitavastatin induced cardioprotection from IR injury by activation of PI3K/Akt pathway and inhibition of inflammation and cardiomyocyte death in this model. This strategy can be developed as an innovative cardioprotective modality that may advance currently unsatisfactory reperfusion therapy for AMI.

  18. A Translational Study of a New Therapeutic Approach for Acute Myocardial Infarction: Nanoparticle-Mediated Delivery of Pitavastatin into Reperfused Myocardium Reduces Ischemia-Reperfusion Injury in a Preclinical Porcine Model

    Science.gov (United States)

    Ichimura, Kenzo; Matoba, Tetsuya; Nakano, Kaku; Tokutome, Masaki; Honda, Katsuya; Koga, Jun-ichiro; Egashira, Kensuke

    2016-01-01

    Background There is an unmet need to develop an innovative cardioprotective modality for acute myocardial infarction, for which interventional reperfusion therapy is hampered by ischemia-reperfusion (IR) injury. We recently reported that bioabsorbable poly(lactic acid/glycolic acid) (PLGA) nanoparticle-mediated treatment with pitavastatin (pitavastatin-NP) exerts a cardioprotective effect in a rat IR injury model by activating the PI3K-Akt pathway and inhibiting inflammation. To obtain preclinical proof-of-concept evidence, in this study, we examined the effect of pitavastatin-NP on myocardial IR injury in conscious and anesthetized pig models. Methods and Results Eighty-four Bama mini-pigs were surgically implanted with a pneumatic cuff occluder at the left circumflex coronary artery (LCx) and telemetry transmitters to continuously monitor electrocardiogram as well as to monitor arterial blood pressure and heart rate. The LCx was occluded for 60 minutes, followed by 24 hours of reperfusion under conscious conditions. Intravenous administration of pitavastatin-NP containing ≥ 8 mg/body of pitavastatin 5 minutes before reperfusion significantly reduced infarct size; by contrast, pitavastatin alone (8 mg/body) showed no therapeutic effects. Pitavastatin-NP produced anti-apoptotic effects on cultured cardiomyocytes in vitro. Cardiac magnetic resonance imaging performed 4 weeks after IR injury revealed that pitavastatin-NP reduced the extent of left ventricle remodeling. Importantly, pitavastatin-NP exerted no significant effects on blood pressure, heart rate, or serum biochemistry. Exploratory examinations in anesthetized pigs showed pharmacokinetic analysis and the effects of pitavastatin-NP on no-reflow phenomenon. Conclusions NP-mediated delivery of pitavastatin to IR-injured myocardium exerts cardioprotective effects on IR injury without apparent adverse side effects in a preclinical conscious pig model. Thus, pitavastatin-NP represents a novel therapeutic

  19. Beautiful Data The Stories Behind Elegant Data Solutions

    CERN Document Server

    Segaran, Toby

    2009-01-01

    In this insightful book, you'll learn from the best data practitioners in the field just how wide-ranging -- and beautiful -- working with data can be. Join 39 contributors as they explain how they developed simple and elegant solutions on projects ranging from the Mars lander to a Radiohead video. With Beautiful Data, you will: Explore the opportunities and challenges involved in working with the vast number of datasets made available by the WebLearn how to visualize trends in urban crime, using maps and data mashupsDiscover the challenges of designing a data processing system that works wi

  20. On the beauty of nature, paintings and music

    OpenAIRE

    Ekin Çoraklı

    2014-01-01

    There is a wide range of things that are classified by humans in terms of their level of beauty. The word ‘beautiful’ is used to define some of the natural entities living and nonliving, unnatural objects or ideas produced by humans, and the works of art, which are unique products of human hand and brain. Beauty, as a concept awakening a common feeling of pleasure, may mean something deeper than we are aware of. This meaning is perhaps hidden in its deeper aspects, which we have to give effor...

  1. Beauty, charm and hyperon production at fixed-target experiments

    Energy Technology Data Exchange (ETDEWEB)

    Erik Gottschalk

    2002-12-11

    Over the years fixed-target experiments have performed numerous studies of particle production in strong interactions. The experiments have been performed with different types of beam particles of varying energies, and many different target materials. Since the physics of particle production is still not understood, ongoing research of phenomena that we observe as beauty, charm and strange-particle production is crucial if we are to gain an understanding of these fundamental processes. It is in this context that recent results from fixed-target experiments on beauty, charm, and hyperon production will be reviewed.

  2. Beautiful Testing Leading Professionals Reveal How They Improve Software

    CERN Document Server

    Goucher, Adam

    2009-01-01

    Successful software depends as much on scrupulous testing as it does on solid architecture or elegant code. But testing is not a routine process, it's a constant exploration of methods and an evolution of good ideas. Beautiful Testing offers 23 essays from 27 leading testers and developers that illustrate the qualities and techniques that make testing an art. Through personal anecdotes, you'll learn how each of these professionals developed beautiful ways of testing a wide range of products -- valuable knowledge that you can apply to your own projects. Here's a sample of what you'll find i

  3. Open charm and beauty production in hadron reactions

    Energy Technology Data Exchange (ETDEWEB)

    Lykasov, G.I.; Lyubushkin, V.V.; Bednyakov, V.A. [Joint Institute for Nuclear Research, 141980, Dubna, Moscow region (Russian Federation)

    2010-01-15

    The production of charmed and beauty hadrons in proton-proton and proton-antiproton collisions at high energies is analyzed within the modified quark-gluon string model (QGSM) including the internal motion of quarks in colliding hadrons. It is shown that using both the QGSM and NLO QCD one can describe these experimental data rather successfully in a wide region of transverse momenta. We also present some predictions for the future experiments on the beauty baryon production in pp collisions at LHC energies and on the charmed meson production in p-bar p reactions at GSI energies.

  4. Simple estimates of the hidden beauty pentaquarks masses

    CERN Document Server

    Kopeliovich, Vladimir

    2015-01-01

    The masses of cryptoexotic pentaquarks with hidden beauty are estimated phenomenologically using the results by the LHCb collaboration which discovered recently the cryptoexotic pentaquarks with hidden charm. The expected masses of the hidden beauty pentaquarks are about $10.8\\, GeV$ and $10.7\\,GeV$ in the limit of some kind of heavy quark symmetry. The states with hidden strangeness considered in similar way have masses above $2\\, Gev$, by several hundreds of $MeV$ higher than states discussed previously in connection with the relatively light positive strangeness pentaquark $\\theta^+$.

  5. CP violation in charm and beauty decays at LHCb

    Energy Technology Data Exchange (ETDEWEB)

    Pepe Altarelli, M., E-mail: monica.pepe.altarelli@cern.ch

    2013-08-15

    LHCb is a dedicated heavy flavour physics precision experiment at the LHC searching for New Physics (NP) beyond the Standard Model (SM) through the study of very rare decays of beauty and charm-flavoured hadrons and precision measurements of CP-violating observables. In this review I will present a selection of recent precision measurements of CP-violating observables in the decays of beauty and charm-flavoured hadrons. These measurements are based on an integrated luminosity of up to 1.0 fb{sup −1} collected by LHCb in 2011.

  6. Beauty photoproduction using decays into electrons at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Chekanov, S.; Derrick, M.; Magill, S. [Argonne National Laboratory, Argonne, IL (US)] (and others)

    2008-05-15

    Photoproduction of beauty quarks in events with two jets and an electron associated with one of the jets has been studied with the ZEUS detector at HERA using an integrated luminosity of 120 pb{sup -1}. The fractions of events containing b quarks, and also of events containing c quarks, were extracted from a likelihood fit using variables sensitive to electron identification as well as to semileptonic decays. Total and differential cross sections for beauty and charm production were measured and compared with next-to-leading-order QCD calculations and Monte Carlo models. (orig.)

  7. Online Beauty Sites Face Uncertain Future(iSyndicate News)

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    This week’s announcements that e-tailersGloss.com and Beautyscene.com are up for sale are astrong indication that online beauty products firms willbe among the early victims of the projected e-commerceshakeout.“With the plethora of beauty sites out there,it hasall come down to which few are going to survive,”saidLisa Allen,an analyst with Forrester Research.“Onlythose with strong brand presence,a solid customer baseand a bricks-and-mortar presence will be around in thelong term.”

  8. ISLAMIC BEAUTY: Socio-Semiotic Analysis of Facial Foam and Body Lotion Advertisement

    OpenAIRE

    Susi Herti Afriani

    2012-01-01

    This paper attempts to answer how Islamic Women define the concept of beauty in Ponds advertisement white beauty facial foam and body lotion on television. This study uses a socio-semiotic approach described through three aspects of social context, namely field, tenor, and mode. It argues that Ponds’ definition of a beauty only refers to physical standards, that is, women who have white skin and use both Ponds White Beauty Facial Foam and Foam Body Lotion. Further, television through Ponds ad...

  9. I know you are beautiful even without looking at you: discrimination of facial beauty in peripheral vision.

    Science.gov (United States)

    Guo, Kun; Liu, Chang Hong; Roebuck, Hettie

    2011-01-01

    Earlier research suggests that facial attractiveness may capture attention at parafovea. However, little is known about how well facial beauty can be detected at parafoveal and peripheral vision. Participants in this study judged relative attractiveness of a face pair presented simultaneously at several eccentricities from the central fixation. The results show that beauty is not only detectable at parafovea but also at periphery. The discrimination performance at parafovea was indistinguishable from the performance around the fovea. Moreover, performance was well above chance even at the periphery. The results show that the visual system is able to use the low-spatial-frequency information to appraise attractiveness. These findings not only provide an explanation why a beautiful face could capture attention when central vision is already engaged elsewhere, but also reveal the potential means by which a crowd of faces is quickly scanned for attractiveness.

  10. Measurement of beauty quark mass at HERA and impact on Higgs production in association with beauty quarks at LHC

    Energy Technology Data Exchange (ETDEWEB)

    Gizhko, Andrii

    2016-06-15

    Three different, but related topics are the subject of this thesis, performed in the context of the ZEUS and CMS groups at DESY. The first measurement of the MS beauty-quark mass m{sub b}(m{sub b}) at an electron-proton collider is presented. The measurement is based on a QCD analysis of beauty production cross sections in deep inelastic (DIS) ep scattering measured by ZEUS at HERA, together with inclusive DIS HERA data, using Next-to-Leading-Order QCD predictions. The measured value of the running beauty-quark mass in the MS scheme was found to be m{sub b}(m{sub b})=4.07±0.14 (fit){sup +0.01}{sub -0.07}(mod.){sup +0.05}{sub -0.00}(param.){sup +0.08}{sub -0.05}( theo.) GeV, which is in good agreement with the world average Particle Data Group value and previous measurements at electron-positron colliders. It is also found to be consistent with the expected running of m{sub b}(μ). A first measurement of the charm-quark mass m{sub c}(μ) running in the MS scheme is presented. The measurement is based on a QCD analysis of the published H1 and ZEUS combination of charm cross section measurements in DIS ep scattering at HERA, together with inclusive DIS HERA data, using Next-to-Leading-Order QCD predictions. The running charm-quark mass m{sub c}(μ) was measured at different scales μ and is presented in a charm-quark mass running plot with a comparison to the world average Particle Data Group m{sub c}(m{sub c}) evolved to higher scales. The running is found to be consistent with the expectations from QCD. The uncertainties of the theoretical predictions for Higgs production in association with beauty-quarks originating from the beauty-quark mass were studied and reduced for massive and massless QCD calculations. The beauty-quark mass measurement m{sub b}(m{sub b}) was used to decrease the variation of the beauty-quark mass to 0.17 GeV. It was shown that the uncertainty from the beauty-quark mass m{sub b}(m{sub b}) in the case of massive calculations for Hb anti b

  11. Mating motives are neither necessary nor sufficient to create the beauty premium.

    Science.gov (United States)

    Hafenbrädl, Sebastian; Dana, Jason

    2017-01-01

    Mating motives lead decision makers to favor attractive people, but this favoritism is not sufficient to create a beauty premium in competitive settings. Further, economic approaches to discrimination, when correctly characterized, could neatly accommodate the experimental and field evidence of a beauty premium. Connecting labor economics and evolutionary psychology is laudable, but mating motives do not explain the beauty premium.

  12. Charm and Beauty Production from Semileptonic Decays at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Juengst, Markus [Universitaet Bonn (Germany)

    2010-07-01

    Measurement of the photoproduction of b-quarks at threshold at HERA The cross section of bb-bar photoproduction in ep collisions is measured with the H1 detector at HERA. Events containing b-quarks are identified through detection of two low momentum electrons in the final state. Semileptonic decays bb-bar {yields} ee X are exploited in the kinematic range of the photon virtuality Q{sup 2} < 1 GeV{sup 2}, the inelasticity 0.2 < y < 0.8 and the pseudorapidity of the b-quarks |{eta}(b), {eta}(b-bar)| < 2. The differential b-quark production cross section is measured as a function of the transverse b-quark momentum and extends the previously experimentally accessible phase space towards the b-quark production threshold. The results are compared to other b-quark cross section measurements, as well as to QCD predictions. Measurement of charm and beauty production in deep inelastic ep scattering from decays into muons at HERA The production of charm and beauty quarks in ep interactions has been measured with the ZEUS detector at HERA for squared four-momentum exchange Q{sup 2}>20 GeV{sup 2}, using an integrated luminosity of 126 pb{sup -1}. Charm and beauty quarks were identified through their decays into muons. Differential cross sections were measured for muon transverse momenta p{sub T}{sup {mu}>}1.5 GeV and pseudo-rapidities -1.6<{eta}{sup {mu}<}2.3, as a function of p{sub T}{sup {mu}}, {eta}{sup {mu}}, Q{sup 2} and Bjorken x. The charm and beauty contributions to the proton structure function F{sub 2} were also extracted. The results agree with previous measurements based on independent techniques and are well described by QCD predictions. Measurement of beauty production in DIS and F2b b-bar extraction at ZEUS Beauty production in deep inelastic scattering with events in which a muon and a jet are observed in the final state has been measured with the ZEUS detector at HERA using an integrated luminosity of 114 pb{sup -1}. The fraction of events with beauty quarks

  13. Media, Construction and Deconstruction of Beauty Myth : – A Case Study of Dove’s Real Beauty Campaign

    OpenAIRE

    2010-01-01

    The paper examines the media portrayal of real women in Dove’s Real Beauty Campaign. Through the semiotic analysis and reception analysis of the ad “Evolution”, the author investigates how Dove attempts to challenge the myth in most beauty advertising and present the “real beauty” idea to the audiences. The study further discusses about the gender issues aroused from the campaign. The findings show that the untouchable images of women are created under the pressures of male-dominated culture....

  14. Beauty of Human Body:Social Beauty, Not Natural Beauty%人体美是社会美而不是自然美

    Institute of Scientific and Technical Information of China (English)

    王树平

    2015-01-01

    人体、人体美是有人的参与而演化形成的,既是在人们劳动生活的作用下演化形成的,也是在人们自觉地直接改造干预下演化形成的,还是在社会关系的作用下演化形成的。社会关系制约着人们的活动范围;社会关系决定着人们的社会和政治地位,也影响着人们的经济状况;社会关系制约着社会分工;社会关系制约着人们的生活方式;因而影响着人体的演化形成。人体是社会性的躯体,人体美是社会美。%Human body and the beauty of human body are evolved under the participation of people.The human body and its beauty are formed under the influence of people′s social life, or rather under the people′s conscious and direct interference, and social relations, since social relations restrict the scope of people′s activities, determine the social and political status of people, and affect people′s economic situation.They restrict social division of labor and people′s lifes-tyles, hence they influence the body′s formation and evolution.Human body is a kind of body of sociality, and beauty of hu-man body is a kind of social beauty.

  15. Specific binding of lacosamide to collapsin response mediator protein 2 (CRMP2) and direct impairment of its canonical function: implications for the therapeutic potential of lacosamide.

    Science.gov (United States)

    Wilson, Sarah M; Khanna, Rajesh

    2015-04-01

    The novel antiepileptic drug lacosamide (LCM; SPM927, Vimpat®) has been heralded as having a dual-mode of action through interactions with both the voltage-gated sodium channel and the neurite outgrowth-promoting collapsin response mediator protein 2 (CRMP2). Lacosamide's ability to dampen neuronal excitability through the voltage-gated sodium channel likely underlies its efficacy in attenuating the symptoms of epilepsy (i.e., seizures). While the role of CRMP2 in epilepsy has not been well studied, given the proposed involvement of circuit reorganization in epileptogenesis, the ability of lacosamide to alter CRMP2 function may prove disease modifying. Recently, however, the validity of lacosamide's interaction with CRMP2 has come under scrutiny. In this review, we address the contradictory reports concerning the binding of lacosamide to CRMP2 as well as the ability of lacosamide to directly impact CRMP2 function. Additionally, we address similarly the contradicting reports regarding the potential disease-modifying effect of lacosamide on the development and progression of epilepsy. As the vast majority of antiepileptic drugs influences only the symptoms of epilepsy, the ability to hinder disease progression would be a major breakthrough in efforts to cure or prevent this debilitating syndrome.

  16. Neural correlates of visual aesthetics--beauty as the coalescence of stimulus and internal state.

    Science.gov (United States)

    Jacobs, Richard H A H; Renken, Remco; Cornelissen, Frans W

    2012-01-01

    How do external stimuli and our internal state coalesce to create the distinctive aesthetic pleasures that give vibrance to human experience? Neuroaesthetics has so far focused on the neural correlates of observing beautiful stimuli compared to neutral or ugly stimuli, or on neural correlates of judging for beauty as opposed to other judgments. Our group questioned whether this approach is sufficient. In our view, a brain region that assesses beauty should show beauty-level-dependent activation during the beauty judgment task, but not during other, unrelated tasks. We therefore performed an fMRI experiment in which subjects judged visual textures for beauty, naturalness and roughness. Our focus was on finding brain activation related to the rated beauty level of the stimuli, which would take place exclusively during the beauty judgment. An initial whole-brain analysis did not reveal such interactions, yet a number of the regions showing main effects of the judgment task or the beauty level of stimuli were selectively sensitive to beauty level during the beauty task. Of the regions that were more active during beauty judgments than roughness judgments, the frontomedian cortex and the amygdala demonstrated the hypothesized interaction effect, while the posterior cingulate cortex did not. The latter region, which only showed a task effect, may play a supporting role in beauty assessments, such as attending to one's internal state rather than the external world. Most of the regions showing interaction effects of judgment and beauty level correspond to regions that have previously been implicated in aesthetics using different stimulus classes, but based on either task or beauty effects alone. The fact that we have now shown that task-stimulus interactions are also present during the aesthetic judgment of visual textures implies that these areas form a network that is specifically devoted to aesthetic assessment, irrespective of the stimulus type.

  17. Echoes of Beauty: In Memory of Pleshette DeArmitt

    Directory of Open Access Journals (Sweden)

    Elaine P. Miller

    2015-12-01

    Full Text Available There is a special poignancy to the fact that Pleshette DeArmitt's essay "Sarah Kofman's Art of Affirmation" foregrounds Freud's essay "On Transience," in which he muses on the fact that beauty seems to be inextricably linked to a fleeting existence.  As DeArmitt writes, "beauty, even in full flowering, foreshadows its own demise, causing what Freud describes as 'a foretaste of mourning.'" Such a transience, in Freud's mind, increases rather than decreases the worth of all that is beautiful. In her essay, DeArmitt argues that Kofman's 1985 text Mélancolie de l'Artreinscribes Freud's text, but brings it into the present by pointing to contemporary art as the occasion for the opening up of a new space, one capable of "dislocat[ing] the space of representation and meaning" and "invent[ing] a space of indetermination and play.” Through dislocation of a fixed reference or meaning and opening up a place for indeterminacy and play, contemporary art acknowledges and celebrates, rather than regrets, the transience of beauty

  18. Cosmetology Curriculum and Training as Seen by Beauty Salons.

    Science.gov (United States)

    San Mateo Coll., CA.

    To evaluate the effectiveness of its cosmetology program, the College of San Mateo sent a questionnaire to beauty salons in the college's service area. Of the 70 questionnaires sent, over half were returned. Eleven courses in the curriculum were ranked by the employer in order of importance to him, the first four being the 1,600 hours of…

  19. Identification of beauty and charm quark jets at LHCb

    NARCIS (Netherlands)

    Aaij, R.; Adeva, B.; Adinolfi, M.; Affolder, A.; Ajaltouni, Z.; Akar, S.; Albrecht, J.; Alessio, F.; Alexander, M.; Ali, S.; Alkhazov, G.; Cartelle, P. Alvarez; Alves, A. A.; Amato, S.; Amerio, S.; Amhis, Y.; An, L.; Anderlini, L.; Andreotti, M.; Andrews, J. E.; Appleby, R. B.; Gutierrez, O. Aquines; Archilli, F.; d'Argent, P.; Artamonov, A.; Artuso, M.; Aslanides, E.; Auriemma, G.; Baalouch, M.; Bachmann, S.; Back, J. J.; Badalov, A.; Baesso, C.; Baldini, W.; Barlow, R. J.; Barschel, C.; Barsuk, S.; Barter, W.; Batozskaya, V.; Battista, V.; Beaucourt, L.; Beddow, J.; Bedeschi, F.; Bediaga, I.; Bel, L. J.; Belyaev, I.; Ben-Haim, E.; Bencivenni, G.; Benson, S.; Benton, J.; Berezhnoy, A.; Bernet, R.; Bertolin, A.; Bettler, M. O.; van Beuzekom, M.; Bien, A.; Bifani, S.; Bird, T.; Birnkraut, A.; Bizzeti, A.; Blake, T.; Blanc, F.; Blouw, J.; Blusk, S.; Bocci, V.; Bondar, A.; Bondar, N.; Bonivento, W.; Borghi, S.; Borsato, M.; Bowcock, T. J. V.; Bowen, E.; Bozzi, C.; Braun, S.; Brett, D.; Britsch, M.; Britton, T.; Brodzicka, J.; Brook, N. H.; Bursche, A.; Buytaert, J.; Cadeddu, S.; Calabrese, R.; Calvi, M.; Calvo Gomez, M.; Campana, P.; Perez, D. Campora; Capriotti, L.; Carbone, A.; Carboni, G.; Cardinale, R.; Cardini, A.; Carniti, P.; Carson, L.; Carvalho Akiba, K.; Casanova Mohr, R.; Casse, G.; Cassina, L.; Garcia, L. Castillo; Cattaneo, M.; Cauet, Ch.; Cavallero, G.; Cenci, R.; Charles, M.; Charpentier, Ph.; Chefdeville, M.; Cheung, S. F.; Chiapolini, N.; Chrzaszcz, M.; Vidal, X. Cid; Ciezarek, G.; Clarke, P. E. L.; Clemencic, M.; Cliff, H. V.; Closier, J.; Coco, V.; Cogan, J.; Cogneras, E.; Cogoni, V.; Cojocariu, L.; Collazuol, G.; Collins, P.; Comerma-Montells, A.; Contu, A.; Cook, A.; Coombes, M.; Coquereau, S.; Corti, G.; Corvo, M.; Counts, I.; Couturier, B.; Cowan, G. A.; Craik, D. C.; Crocombe, A.; Cruz Torres, M.; Cunliffe, S.; Currie, R.; D'Ambrosio, C.; Dalseno, J.; David, P. N. Y.; Davis, A.; De Bruyn, K.; De Capua, S.; De Cian, M.; De Miranda, J. M.; De Paula, L.; De Silva, W.; De Simone, P.; Dean, C. T.; Decamp, D.; Deckenhoff, M.; Del Buono, L.; Deleage, N.; Derkach, D.; Deschamps, O.; Dettori, F.; Dey, B.; Di Canto, A.; Di Ruscio, F.; Donleavy, S.; Dordei, F.; Dorigo, M.; Dosil Suarez, A.; Dossett, D.; Dovbnya, A.; Dreimanis, K.; Dufour, L.; Dujany, G.; Dupertuis, F.; Durante, P.; Dzhelyadin, R.; Dziurda, A.; Dzyuba, A.; Easo, S.; Egede, U.; Egorychev, V.; Eidelman, S.; Eisenhardt, S.; Eitschberger, U.; Ekelhof, R.; Eklund, L.; El Rifai, I.; Elsasser, Ch.; Ely, S.; Esen, S.; Evans, H. M.; Evans, T.; Falabella, A.; Faerber, C.; Farinelli, C.; Farley, N.; Farry, S.; Fay, R.; Ferguson, D.; Fernandez Albor, V.; Ferrari, F.; Ferreira Rodrigues, F.; Ferro-Luzzi, M.; Filippov, S.; Fiore, M.; Fiorini, M.; Firlej, M.; Fitzpatrick, C.; Fiutowski, T.; Fohl, K.; Fol, P.; Fontana, M.; Fontanelli, F.; Forty, R.; Francisco, O.; Frei, C.; Frosini, M.; Furfaro, E.; Gallas Torreira, A.; Galli, D.; Gallorini, S.; Gambetta, S.; Gandelman, M.; Gandini, P.; Garcia Pardinas, J.; Garofoli, J.; Tico, J. Garra; Garrido, L.; Gascon, D.; Gaspar, C.; Gastaldi, U.; Gauld, R.; Gavardi, L.; Gazzoni, G.; Geraci, A.; Gerick, D.; Gersabeck, E.; Gersabeck, M.; Gershon, T.; Ghez, Ph.; Gianelle, A.; Giani, S.; Gibson, V.; Girard, O. G.; Giubega, L.; Gligorov, V. V.; Goebel, C.; Golubkov, D.; Golutvin, A.; Gotti, C.; Gandara, M. Grabalosa; Graciani Diaz, R.; Cardoso, L. A. Granado; Grauges, E.; Graverini, E.; Graziani, G.; Grecu, A.; Greening, E.; Gregson, S.; Griffith, P.; Grillo, L.; Gruenberg, O.; Gui, B.; Gushchin, E.; Guz, Yu.; Gys, T.; Hadjivasiliou, C.; Haefeli, G.; Haen, C.; Haines, S. C.; Hall, S.; Hamilton, B.; Hampson, T.; Han, X.; Hansmann-Menzemer, S.; Harnew, N.; Harnew, S. T.; Harrison, J.; He, J.; Head, T.; Heijne, V.; Hennessy, K.; Henrard, P.; Henry, L.; Hernando Morata, J. A.; van Herwijnen, E.; Hess, M.; Hicheur, A.; Hill, D.; Hoballah, M.; Hombach, C.; Hulsbergen, W.; Humair, T.; Hussain, N.; Hutchcroft, D.; Hynds, D.; Idzik, M.; Ilten, P.; Jacobsson, R.; Jalocha, J.; Jans, E.; Jawahery, A.; Jing, F.; John, M.; Johnson, D.; Jones, C. R.; Joram, C.; Jost, B.; Jurik, N.; Kandybei, S.; Kanso, W.; Karacson, M.; Karbach, T. M.; Karodia, S.; Kelsey, M.; Kenyon, I. R.; Kenzie, M.; Ketel, T.; Khanji, B.; Khurewathanakul, C.; Klaver, S.; Klimaszewski, K.; Kochebina, O.; Kolpin, M.; Komarov, I.; Koppenburg, P.; Korolev, M.; Kravchuk, L.; Kreplin, K.; Kreps, M.; Krocker, G.; Krokovny, P.; Kucewicz, W.; Kucharczyk, M.; Kudryavtsev, V.; Kuonen, A. K.; Kurek, K.; Kvaratskheliya, T.; La Thi, V. N.; Lacarrere, D.; Lafferty, G.; Lai, A.; Lambert, D.; Lambert, R. W.; Lanfranchi, G.; Langenbruch, C.; Langhans, B.; Latham, T.; Lazzeroni, C.; Le Gac, R.; van Leerdam, J.; Lees, J. P.; Lefevre, R.; Leflat, A.; Lefrancois, J.; Leroy, O.; Lesiak, T.; Leverington, B.; Likhomanenko, T.; Liles, M.; Lindner, R.; Linn, C.; Lionetto, F.; Lohn, S.; Longstaff, I.; Lopes, J. H.; Lowdon, P.; Lucchesi, D.; Lucio Martinez, M.; Luo, H.; Lupato, A.; Luppi, E.; Lupton, O.; Machefert, F.; Maciuc, F.; Maev, O.; Maguire, K.; Malde, S.; Malinin, A.; Manca, G.; Mancinelli, G.; Manning, P.; Mapelli, A.; Maratas, J.; Marchand, J. F.; Marconi, U.; Benito, C. Marin; Marino, P.; Maerki, R.; Marks, J.; Martellotti, G.; Martinelli, M.; Santos, D. Martinez; Martinez Vidal, F.; Martins Tostes, D.; Massafferri, A.; Matev, R.; Mathad, A.; Mathe, Z.; Matteuzzi, C.; Matthieu, K.; Mauri, A.; Maurin, B.; Mazurov, A.; McCann, M.; McCarthy, J.; Mcnab, A.; McNulty, R.; Meadows, B.; Meier, F.; Merk, M.; Milanes, D. A.; Minard, M. N.; Mitzel, D. S.; Rodriguez, J. Molina; Monteil, S.; Morandin, M.; Morawski, P.; Morda, A.; Morello, M. J.; Moron, J.; Morris, A. B.; Mountain, R.; Muheim, F.; Mueller, J.; Mueller, K.; Mueller, V.; Mussini, M.; Muster, B.; Naik, P.; Nakada, T.; Nandakumar, R.; Nasteva, I.; Needham, M.; Neri, N.; Neubert, S.; Neufeld, N.; Neuner, M.; Nguyen, A. D.; Nguyen-Mau, C.; Niess, V.; Niet, R.; Nikitin, N.; Nikodem, T.; Ninci, D.; Novoselov, A.; O'Hanlon, D. P.; Oblakowska-Mucha, A.; Obraztsov, V.; Ogilvy, S.; Okhrimenko, O.; Oldeman, R.; Onderwater, C. J. G.; Osorio Rodrigues, B.; Otalora Goicochea, J. M.; Otto, A.; Owen, P.; Oyanguren, A.; Palano, A.; Palombo, F.; Palutan, M.; Papanestis, A.; Pappagallo, M.; Pappalardo, L. L.; Parkes, C.; Passaleva, G.; Patel, G. D.; Patrignani, C.; Pearce, A.; Pellegrino, A.; Penso, G.; Altarelli, M. Pepe; Perazzini, S.; Perret, P.; Pescatore, L.; Petridis, K.; Petrolini, A.; Petruzzo, M.; Picatoste Olloqui, E.; Pietrzyk, B.; Pilar, T.; Pinci, D.; Pistone, A.; Piucci, A.; Playfer, S.; Plo Casasus, M.; Poikela, T.; Polci, F.; Poluektov, A.; Polyakov, I.; Polycarpo, E.; Popov, A.; Popov, D.; Popovici, B.; Potterat, C.; Price, E.; Price, J. D.; Prisciandaro, J.; Pritchard, A.; Prouve, C.; Pugatch, V.; Navarro, A. Puig; Punzi, G.; Qian, W.; Quagliani, R.; Rachwal, B.; Rademacker, J. H.; Rakotomiaramanana, B.; Rama, M.; Rangel, M. S.; Raniuk, I.; Rauschmayr, N.; Raven, G.; Redi, F.; Reichert, S.; Reid, M. M.; dos Reis, A. C.; Ricciardi, S.; Richards, S.; Rihl, M.; Rinnert, K.; Rives Molina, V.; Rodrigues, A. B.; Rodrigues, E.; Rodriguez Lopez, J. A.; Perez, P. Rodriguez; Roiser, S.; Romanovsky, V.; Romero Vidal, A.; Rotondo, M.; Rouvinet, J.; Ruf, T.; Ruiz, H.; Ruiz Valls, P.; Saborido Silva, J. J.; Sagidova, N.; Sail, P.; Saitta, B.; Salustino Guimaraes, V.; Sanchez Mayordomo, C.; Sanmartin Sedes, B.; Santacesaria, R.; Santamarina Rios, C.; Santimaria, M.; Santovetti, E.; Sarti, A.; Satriano, C.; Satta, A.; Saunders, D. M.; Savrina, D.; Schindler, H.; Schlupp, M.; Schmelling, M.; Schmelzer, T.; Schmidt, B.; Schneider, O.; Schopper, A.; Schubiger, M.; Schune, M. H.; Schwemmer, R.; Sciascia, B.; Sciubba, A.; Semennikov, A.; Sepp, I.; Serra, N.; Serrano, J.; Sestini, L.; Seyfert, P.; Shapkin, M.; Shapoval, I.; Shcheglov, Y.; Shears, T.; Shekhtman, L.; Shevchenko, V.; Shires, A.; Coutinho, R. Silva; Simi, G.; Sirendi, M.; Skidmore, N.; Skillicorn, I.; Skwarnicki, T.; Snoek, H.; Sokoloff, M. D.; Soler, F. J. P.; Soomro, F.; Souza, D.; Souza De Paula, B.; Spaan, B.; Spradlin, P.; Sridharan, S.; Stagni, F.; Stahl, M.; Stahl, S.; Steinkamp, O.; Stenyakin, O.; Sterpka, F.; Stevenson, S.; Stone, S.; Storaci, B.; Stracka, S.; Straticiuc, M.; Straumann, U.; Sutcliffe, W.; Swientek, K.; Swientek, S.; Syropoulos, V.; Szczekowski, M.; Szczypka, P.; Szumlak, T.; T'Jampens, S.; Tekampe, T.; Teklishyn, M.; Tellarini, G.; Teubert, F.; van Tilburg, J.; Tisserand, V.; Tobin, M.; Todd, J.; Tolk, S.; Tomassetti, L.; Tonelli, D.; Topp-Joergensen, S.; Torr, N.; Tournefier, E.; Tourneur, S.; Trabelsi, K.; Tresch, M.; Trisovic, A.; Tsaregorodtsev, A.; Tsopelas, P.; Tuning, N.; Ukleja, A.; Ustyuzhanin, A.; Uwer, U.; Vacca, C.; Vagnoni, V.; Valenti, G.; Vallier, A.; Gomez, R. Vazquez; Vazquez Regueiro, P.; Vazquez Sierra, C.; Vecchi, S.; Velthuis, J. J.; Veltri, M.; Veneziano, G.; Vesterinen, M.; Viaud, B.; Vieira, D.; Vieites Diaz, M.; Vilasis-Cardona, X.; Vollhardt, A.; Volyanskyy, D.; Voong, D.; Vorobyev, A.; Vorobyev, V.; Voss, C.; Waldi, R.; Wallace, C.; Wallace, R.; Wandernoth, S.; Ward, D. R.; Watson, N. K.; Websdale, D.; Weiden, A.; Whitehead, M.; Wiedner, D.; Wilkinson, G.; Wilson, F. F.; Wimberley, J.; Wishahi, J.; Wislicki, W.; Witek, M.; Wormser, G.; Wotton, S. A.; Wright, S.; Wyllie, K.; Xie, Y.; Yang, Z.; Yuan, X.; Yushchenko, O.; Zangoli, M.; Zavertyaev, M.; Zhelezov, A.; Zhokhov, A.; Zhong, L.

    2015-01-01

    Identification of jets originating from beauty and charm quarks is important for measuring Standard Model processes and for searching for new physics. The performance of algorithms developed to select b- and c-quark jets is measured using data recorded by LHCb from proton-proton collisions at root s

  20. Measurement of beauty production from dimuon events at HERA

    NARCIS (Netherlands)

    Chekanov, S.; Derrick, M.; Magill, S.; Musgrave, B.; Nicholass, D.; Repond, J.; Yoshida, R.; Mattingly, M. C. K.; Antonioli, P.; Bari, G.; Bellagamba, L.; Boscherini, D.; Bruni, A.; Bruni, G.; Cindolo, F.; Corradi, M.; Iacobucci, G.; Margotti, A.; Nania, R.; Polini, A.; Antonelli, S.; Basile, M.; Bindi, M.; Cifarelli, L.; Contin, A.; De Pasquale, S.; Sartorelli, G.; Zichichi, A.; Bartsch, D.; Brock, I.; Hartmann, H.; Hilger, E.; Jakob, H. -P.; Juengst, M.; Nuncio-Quiroz, A. E.; Samson, U.; Schoenberg, V.; Shehzadi, R.; Wlasenko, M.; Brook, N. H.; Heath, G. P.; Kaur, M.; Kaur, P.; Singh, I.; Capua, M.; Fazio, S.; Mastroberardino, A.; Schioppa, M.; Susinno, G.; Tassi, E.; Kim, J. Y.; Ibrahim, Z. A.; Kamaluddin, B.; Abdullah, W. A. T. Wan; Ning, Y.; Ren, Z.; Sciulli, F.; Chwastowski, J.; Eskreys, A.; Figiel, J.; Galas, A.; Olkiewicz, K.; Stopa, P.; Zawiejski, L.; Adamczyk, L.; Bold, T.; Grabowska-Bold, I.; Kisielewska, D.; Lukasik, J.; Przybycien, M.; Suszycki, L.; Kotanski, A.; Slominski, W.; Behnke, O.; Behrens, U.; Bloch, I.; Blohm, C.; Bonato, A.; Borras, K.; Ciesielski, R.; Coppola, N.; Fourletova, J.; Geiser, A.; Goettlicher, P.; Grebenyuk, J.; Gregor, I.; Gutsche, O.; Haas, T.; Hain, W.; Huettmann, A.; Januschek, F.; Kahle, B.; Katkov, I. I.; Klein, U.; Koetz, U.; Kowalski, H.; Lisovyi, M.; Lobodzinska, E.; Loehr, B.; Mankel, R.; Melzer-Pellmann, I. -A.; Miglioranzi, S.; Montanari, A.; Namsoo, T.; Notz, D.; Parenti, A.; Rinaldi, L.; Roloff, P.; Rubinsky, I.; Schneekloth, U.; Spiridonov, A.; Szuba, D.; Szuba, J.; Theedt, T.; Ukleja, J.; Wolf, G.; Wrona, K.; Molina, A. G. Yaguees; Youngman, C.; Zeuner, W.; Drugakov, V.; Lohmann, W.; Schlenstedt, S.; Barbagli, G.; Gallo, E.; Pelfer, P. G.; Bamberger, A.; Dobur, D.; Karstens, F.; Vlasov, N. N.; Bussey, P. J.; Doyle, A. T.; Dunne, W.; Forrest, M.; Rosin, M.; Saxon, D. H.; Skillicorn, I. O.; Gialas, I.; Papageorgiu, K.; Holm, U.; Klanner, R.; Lohrmann, E.; Perrey, H.; Schleper, P.; Schoerner-Sadenius, T.; Sztuk, J.; Stadie, H.; Turcato, M.; Foudas, C.; Fry, C.; Long, K. R.; Tapper, A. D.; Matsumoto, T.; Nagano, K.; Tokushuku, K.; Yamada, S.; Yamazaki, Y.; Barakbaev, A. N.; Boos, E. G.; Pokrovskiy, N. S.; Zhautykov, B. O.; Aushev, V.; Bachynska, O.; Borodin, M.; Kadenko, I.; Kozulia, A.; Libov, V.; Lontkovskyi, D.; Makarenko, I.; Sorokin, Iu.; Verbytskyi, A.; Volynets, O.; Son, D.; de Favereau, J.; Piotrzkowski, K.; Barreiro, F.; Glasman, C.; Jimenez, M.; Labarga, L.; del Peso, J.; Ron, E.; Soares, M.; Terron, J.; Zambrana, M.; Corriveau, F.; Schwartz, J.; Walsh, R.; Tsurugai, T.; Antonov, A.; Dolgoshein, B. A.; Gladkov, D.; Sosnovtsev, V.; Stifutkin, A.; Suchkov, S.; Dementiev, R. K.; Ermolov, P. F.; Gladilin, L. K.; Golubkov, Yu. A.; Khein, L. A.; Korzhavina, I. A.; Kuzmin, V. A.; Levchenko, B. B.; Lukina, O. Yu.; Proskuryakov, A. S.; Shcheglova, L. M.; Zotkin, D. S.; Abt, I.; Caldwell, A.; Kollar, D.; Reisert, B.; Schmidke, W. B.; Grigorescu, G.; Keramidas, A.; Kooijman, P.; Pellegrino, A.; Tiecke, H.; Vazquez, M.; Bruemmer, N.; Bylsma, B.; Durkin, L. S.; Lee, A.; Ling, T. Y.; Allfrey, P. D.; Bell, M. A.; Cooper-Sarkar, A. M.; Devenish, R. C. E.; Fer-rando, J.; Foster, B.; Gwenlan, C.; Korcsak-Gorzo, K.; Oliver, K.; Robertson, A.; Uribe-Estrada, C.; Walczak, R.; Bertolin, A.; Dal Corso, F.; Dusini, S.; Longhin, A.; Stanco, L.; Bellan, P.; Brugnera, R.; Carlin, R.; Garfagnini, A.; Limentani, S.; Oh, B. Y.; Raval, A.; Whitmore, J. J.; Iga, Y.; D'Agostini, G.; Marini, G.; Nigro, A.; Cole, J. E.; Hart, J. C.; Abramowicz, H.; Ingbir, R.; Kananov, S.; Stern, A.; Kuze, M.; Maeda, J.; Hori, R.; Kagawa, S.; Okazaki, N.; Tawara, T.; Hamatsu, R.; Kaji, H.; Kitamura, S.; Ota, O.; Ri, Y. D.; Costa, M.; Ferrero, M. I.; Monaco, V.; Sacchi, R.; Solano, A.; Arneodo, M.; Ruspa, M.; Fourletov, S.; Stewart, T. P.; Boutle, S. K.; Butterworth, J. M.; Jones, T. W.; Loizides, J. H.; Wing, M.; Brzozowska, B.; Ciborowski, J.; Grzelak, G.; Kulinski, P.; Luzniak, P.; Malka, J.; Nowak, R. J.; Pawlak, J. M.; Perlanski, W.; Tymieniecka, T.; Zarnecki, A. F.; Adamus, M.; Plucinski, P.; Ukleja, A.; Eisenberg, Y.; Hochman, D.; Karshon, U.; Brownson, E.; Reeder, D. D.; Savin, A. A.; Smith, W. H.; Wolfe, H.; Bhadra, S.; Catterall, C. D.; Hartner, G.; Menary, S.; Noor, U.; Standage, J.; Whyte, J.

    2009-01-01

    Beauty production in events containing two muons in the final state has been measured with the ZEUS detector at HERA using an integrated luminosity of 114 pb(-1). A low transverse-momentum threshold for muon identification, in combination with the large rapidity coverage of the ZEUS muon system, giv

  1. Just My Imagination: Beauty premium and the evolved mental model.

    Science.gov (United States)

    Oda, Ryo

    2017-01-01

    Imagination, an important feature of the human mind, may be at the root of the beauty premium. The evolved human capacity for simulating the real world, developed as an adaptation to a complex social environment, may offer the key to understanding this and many other aspects of human behavior.

  2. Mathematical beauty in service of deep approach to learning

    DEFF Research Database (Denmark)

    Karamehmedovic, Mirza

    2015-01-01

    , emphasising the beauty of the underlying mathematical structure. Into this I integrated frequent and activating dialogue with the students. In section 1 I describe the course and the students in more detail. Section 2 details and justifies the pedagogical elements I introduced into the lectures; my central...

  3. Beauty vector meson decay constants from QCD sum rules

    Energy Technology Data Exchange (ETDEWEB)

    Lucha, Wolfgang [Institute for High Energy Physics, Austrian Academy of Sciences, Nikolsdorfergasse 18, A-1050 Vienna (Austria); Melikhov, Dmitri [Institute for High Energy Physics, Austrian Academy of Sciences, Nikolsdorfergasse 18, A-1050 Vienna (Austria); D. V. Skobeltsyn Institute of Nuclear Physics, M. V. Lomonosov Moscow State University, 119991, Moscow (Russian Federation); Simula, Silvano [Istituto Nazionale di Fisica Nucleare, Sezione di Roma Tre, Via della Vasca Navale 84, I-00146, Roma (Italy)

    2016-01-22

    We present the outcomes of a very recent investigation of the decay constants of nonstrange and strange heavy-light beauty vector mesons, with special emphasis on the ratio of any such decay constant to the decay constant of the corresponding pseudoscalar meson, by means of Borel-transformed QCD sum rules. Our results suggest that both these ratios are below unity.

  4. A hyperactive sleeping beauty transposase enhances transgenesis in zebrafish embryos

    Directory of Open Access Journals (Sweden)

    Lardelli Michael

    2010-11-01

    Full Text Available Abstract Background Transposons are useful molecular tools for transgenesis. The 'sleeping beauty' transposon is a synthetic member of the Tc1/mariner transposon family. Davidson et al. (2003 previously described a vector for zebrafish transgenesis consisting of the inverted repeats of 'sleeping beauty' flanking the gene to be transposed. Subsequently, there have been attempts to enhance the transpositional activity of 'sleeping beauty' by increasing the activity of its transposase. Recently, Mates et al. (2009 generated a hyperactive transposase giving a 100-fold increased transposition rate in mouse embryos. Findings The aim of this experiment was to determine whether this novel hyperactive transposase enhances transgenesis in zebrafish embryos. Using our previously characterised mitfa-amyloidβ-GFP transgene, we observed an eight-fold enhancement in transient transgenesis following detection of transgene expression in melanophores by whole mount in-situ hybridisation. However, high rates of defective embryogenesis were also observed. Conclusion The novel hyperactive 'sleeping beauty' transposase enhances the rate of transgenesis in zebrafish embryos.

  5. The "F" Word: Is Feminism Incompatible with Beauty and Romance?

    Science.gov (United States)

    Rudman, Laurie A.; Fairchild, Kimberly

    2007-01-01

    Three studies examined the predictive utility of heterosexual relationship concerns vis-a-vis support for feminism. Study 1 showed that beauty is perceived to be at odds with feminism, for both genders. The stereotype that feminists are unattractive was robust, but fully accounted for by romance-related attributions. Moreover, more attractive…

  6. Beauty Vector Meson Decay Constants from QCD Sum Rules

    CERN Document Server

    Lucha, Wolfgang; Simula, Silvano

    2016-01-01

    We present the outcomes of a very recent investigation of the decay constants of nonstrange and strange heavy-light beauty vector mesons, with special emphasis on the ratio of any such decay constant to the decay constant of the corresponding pseudoscalar meson, by means of Borel-transformed QCD sum rules. Our results suggest that both these ratios are below unity.

  7. Isovector and hidden-beauty partners of the X(3872)

    CERN Document Server

    Hogaasen, Hallstein; Richard, Jean-Marc; Sorba, Paul

    2014-01-01

    The isovector partners of the X(3872), recently found at BES III, Belle and CLEO-c were predicted in a simple model based on the chromomagnetic interaction among quarks (H. Hogaasen, J-M. Richard and P. Sorba, Phys. Rev. D73, 054013, 2006). The extension to the hidden-beauty sector is discussed.

  8. Beauty vector meson decay constants from QCD sum rules

    Science.gov (United States)

    Lucha, Wolfgang; Melikhov, Dmitri; Simula, Silvano

    2016-01-01

    We present the outcomes of a very recent investigation of the decay constants of nonstrange and strange heavy-light beauty vector mesons, with special emphasis on the ratio of any such decay constant to the decay constant of the corresponding pseudoscalar meson, by means of Borel-transformed QCD sum rules. Our results suggest that both these ratios are below unity.

  9. pH-Responsive therapeutic solid lipid nanoparticles for reducing P-glycoprotein-mediated drug efflux of multidrug resistant cancer cells.

    Science.gov (United States)

    Chen, Hsin-Hung; Huang, Wen-Chia; Chiang, Wen-Hsuan; Liu, Te-I; Shen, Ming-Yin; Hsu, Yuan-Hung; Lin, Sung-Chyr; Chiu, Hsin-Cheng

    2015-01-01

    administration of DOX-loaded SLNs show that the SLNs have no observable side effects. These results indicate that the C-PEG-SLN is a promising platform for the delivery of therapeutic agents for MDR cancer chemotherapy.

  10. Measurement of beauty and charm production in deep inelastic scattering at HERA and measurement of the beauty-quark mass

    CERN Document Server

    Abramowicz, H; Adamczyk, L.; Adamus, M.; Aggarwal, R.; Antonelli, S.; Arslan, O.; Aushev, V.; Aushev, Y.; Bachynska, O.; Barakbaev, A.N.; Bartosik, N.; Behnke, O.; Behr, J.; Behrens, U.; Bertolin, A.; Bhadra, S.; Bloch, I.; Bokhonov, V.; Boos, E.G.; Borras, K.; Brock, I.; Brugnera, R.; Bruni, A.; Brzozowska, B.; Bussey, P.J.; Caldwell, A.; Capua, M.; Catterall, C.D.; Chwastowski, J.; Ciborowski, J.; Ciesielski, R.; Cooper-Sarkar, A.M.; Corradi, M.; Corriveau, F.; D'Agostini, G.; Dementiev, R.K.; Devenish, R.C.E.; Dolinska, G.; Drugakov, V.; Dusini, S.; Ferrando, J.; Figiel, J.; Foster, B.; Gach, G.; Garfagnini, A.; Geiser, A.; Gizhko, A.; Gladilin, L.K.; Gogota, O.; Golubkov, Yu. A.; Grebenyuk, J.; Gregor, I.; Grzelak, G.; Gueta, O.; Guzik, M.; Hain, W.; Hartner, G.; Hochman, D.; Hori, R.; Ibrahim, Z.A.; Iga, Y.; Ishitsuka, M.; Iudin, A.; Januschek, F.; Kadenko, I.; Kananov, S.; Kanno, T.; Karshon, U.; Kaur, M.; Kaur, P.; Khein, L.A.; Kisielewska, D.; Klanner, R.; Klein, U.; Kondrashova, N.; Kononenko, O.; Korol, Ie.; Korzhavina, I.A.; Kotanski, A.; Kotz, U.; Kovalchuk, N.; Kowalski, H.; Kuprash, O.; Kuze, M.; Levchenko, B.B.; Levy, A.; Libov, V.; Limentani, S.; Lisovyi, M.; Lobodzinska, E.; Lohmann, W.; Lohr, B.; Lohrmann, E.; Longhin, A.; Lontkovskyi, D.; Lukina, O.Yu.; Maeda, J.; Makarenko, I.; Malka, J.; Martin, J.F.; Mergelmeyer, S.; Idris, F.Mohamad; Mujkic, K.; Myronenko, V.; Nagano, K.; Nigro, A.; Nobe, T.; Notz, D.; Nowak, R.J.; Olkiewicz, K.; Onishchuk, Yu.; Paul, E.; Perlanski, W.; Perrey, H.; Pokrovskiy, N.S.; Proskuryakov, A.S.; Przybycien, M.; Raval, A.; Roloff, P.; Rubinsky, I.; Ruspa, M.; Samojlov, V.; Saxon, D.H.; Schioppa, M.; Schmidke, W.B.; Schneekloth, U.; Schorner-Sadenius, T.; Schwartz, J.; Shcheglova, L.M.; Shehzadi, R.; Shevchenko, R.; Shkola, O.; Singh, I.; Skillicorn, I.O.; Slominski, W.; Sola, V.; Solano, A.; Spiridonov, A.; Stanco, L.; Stefaniuk, N.; Stern, A.; Stewart, T.P.; Stopa, P.; Sztuk-Dambietz, J.; Szuba, D.; Szuba, J.; Tassi, E.; Temiraliev, T.; Tokushuku, K.; Tomaszewska, J.; Trofymov, A.; Trusov, V.; Tsurugai, T.; Turcato, M.; Turkot, O.; Tymieniecka, T.; Verbytskyi, A.; Viazlo, O.; Walczak, R.; Wan Abdullah, W.A.T.; Wichmann, K.; Wing, M.; Wolf, G.; Yamada, S.; Yamazaki, Y.; Zakharchuk, N.; Zarnecki, A.F.; Zawiejski, L.; Zenaiev, O.; Zhautykov, B.O.; Zhmak, N.; Zotkin, D.S.

    2014-01-01

    The production of beauty and charm quarks in ep interactions has been studied with the ZEUS detector at HERA for exchanged four-momentum squared 5 < Q^2 < 1000 GeV^2 using an integrated luminosity of 354 pb^{-1}. The beauty and charm content in events with at least one jet have been extracted using the invariant mass of charged tracks associated with secondary vertices and the decay-length significance of these vertices. Differential cross sections as a function of Q^2, Bjorken x, jet transverse energy and pseudorapidity were measured and compared with next-to-leading-order QCD calculations. The beauty and charm contributions to the proton structure functions were extracted from the double-differential cross section as a function of x and Q^2. The running beauty-quark mass, m_b at the scale m_b, was determined from a QCD fit at next-to-leading order to HERA data for the first time and found to be 4.07 \\pm 0.14 (fit} ^{+0.01}_{-0.07} (mod.) ^{+0.05}_{-0.00} (param.) ^{+0.08}_{-0.05} (theo) GeV.

  11. Measurement of beauty and charm production in deep inelastic scattering at HERA and measurement of the beauty-quark mass

    Science.gov (United States)

    Abramowicz, H.; Abt, I.; Adamczyk, L.; Adamus, M.; Aggarwal, R.; Antonelli, S.; Arslan, O.; Aushev, V.; Aushev, Y.; Bachynska, O.; Barakbaev, A. N.; Bartosik, N.; Behnke, O.; Behr, J.; Behrens, U.; Bertolin, A.; Bhadra, S.; Bloch, I.; Bokhonov, V.; Boos, E. G.; Borras, K.; Brock, I.; Brugnera, R.; Bruni, A.; Brzozowska, B.; Bussey, P. J.; Caldwell, A.; Capua, M.; Catterall, C. D.; Chwastowski, J.; Ciborowski, J.; Ciesielski, R.; Cooper-Sarkar, A. M.; Corradi, M.; Corriveau, F.; D'Agostini, G.; Dementiev, R. K.; Devenish, R. C. E.; Dolinska, G.; Drugakov, V.; Dusini, S.; Ferrando, J.; Figiel, J.; Foster, B.; Gach, G.; Garfagnini, A.; Geiser, A.; Gizhko, A.; Gladilin, L. K.; Gogota, O.; Golubkov, Yu. A.; Grebenyuk, J.; Gregor, I.; Grzelak, G.; Gueta, O.; Guzik, M.; Hain, W.; Hartner, G.; Hochman, D.; Hori, R.; Ibrahim, Z. A.; Iga, Y.; Ishitsuka, M.; Iudin, A.; Januschek, F.; Kadenko, I.; Kananov, S.; Kanno, T.; Karshon, U.; Kaur, M.; Kaur, P.; Khein, L. A.; Kisielewska, D.; Klanner, R.; Klein, U.; Kondrashova, N.; Kononenko, O.; Korol, Ie.; Korzhavina, I. A.; Kotanski, A.; Kötz, U.; Kovalchuk, N.; Kowalski, H.; Kuprash, O.; Kuze, M.; Levchenko, B. B.; Levy, A.; Libov, V.; Limentani, S.; Lisovyi, M.; Lobodzinska, E.; Lohmann, W.; Löhr, B.; Lohrmann, E.; Longhin, A.; Lontkovskyi, D.; Lukina, O. Yu.; Maeda, J.; Makarenko, I.; Malka, J.; Martin, J. F.; Mergelmeyer, S.; Mohamad Idris, F.; Mujkic, K.; Myronenko, V.; Nagano, K.; Nigro, A.; Nobe, T.; Notz, D.; Nowak, R. J.; Olkiewicz, K.; Onishchuk, Yu.; Paul, E.; Perlanski, W.; Perrey, H.; Pokrovskiy, N. S.; Proskuryakov, A. S.; Przybycien, M.; Raval, A.; Roloff, P.; Rubinsky, I.; Ruspa, M.; Samojlov, V.; Saxon, D. H.; Schioppa, M.; Schmidke, W. B.; Schneekloth, U.; Schörner-Sadenius, T.; Schwartz, J.; Shcheglova, L. M.; Shehzadi, R.; Shevchenko, R.; Shkola, O.; Singh, I.; Skillicorn, I. O.; Slominski, W.; Sola, V.; Solano, A.; Spiridonov, A.; Stanco, L.; Stefaniuk, N.; Stern, A.; Stewart, T. P.; Stopa, P.; Sztuk-Dambietz, J.; Szuba, D.; Szuba, J.; Tassi, E.; Temiraliev, T.; Tokushuku, K.; Tomaszewska, J.; Trofymov, A.; Trusov, V.; Tsurugai, T.; Turcato, M.; Turkot, O.; Tymieniecka, T.; Verbytskyi, A.; Viazlo, O.; Walczak, R.; Wan Abdullah, W. A. T.; Wichmann, K.; Wing, M.; Wolf, G.; Yamada, S.; Yamazaki, Y.; Zakharchuk, N.; Żarnecki, A. F.; Zawiejski, L.; Zenaiev, O.; Zhautykov, B. O.; Zhmak, N.; Zotkin, D. S.

    2014-10-01

    The production of beauty and charm quarks in ep interactions has been studied with the ZEUS detector at HERA for exchanged four-momentum squared 5 < Q 2 < 1000 GeV2 using an integrated luminosity of 354 pb-1. The beauty and charm content in events with at least one jet have been extracted using the invariant mass of charged tracks associated with secondary vertices and the decay-length significance of these vertices. Differential cross sections as a function of Q 2, Bjorken x, jet trans- verse energy and pseudorapidity were measured and compared with next-to-leading-order QCD calculations. The beauty and charm contributions to the proton structure functions were extracted from the double-differential cross section as a function of x and Q 2. The running beauty-quark mass, m b at the scale m b , was determined from a QCD fit at next-to-leading order to HERA data for the first time and found to be m b ( m b ) = 4.07 ± 0.14 (fit){-/0.07 + 0.01}(mod.){-/0.00 + 0.05}(param.){-/0.05 + 0.08}(theo.) GeV.

  12. Measurement of beauty and charm production in deep inelastic scattering at HERA and measurement of the beauty-quark mass

    Energy Technology Data Exchange (ETDEWEB)

    Abramowicz, H. [Tel Aviv Univ. (Israel). School of Physics; Max Planck Institute for Physics, Munich (Germany); Abt, I. [Max Planck Institute for Physics, Munich (Germany); Adamczyk, L. [AGH-Univ. of Science and Technology, Krakow (Poland). Faculty of Physics and Applied Computer Science; Collaboration: ZEUS Collaboration; and others

    2014-05-15

    The production of beauty and charm quarks in ep interactions has been studied with the ZEUS detector at HERA for exchanged four-momentum squared 5beauty and charm content in events with at least one jet have been extracted using the invariant mass of charged tracks associated with secondary vertices and the decay-length significance of these vertices. Differential cross sections as a function of Q{sup 2}, Bjorken x, jet transverse energy and pseudorapidity were measured and compared with next-to-leading-order QCD calculations. The beauty and charm contributions to the proton structure functions were extracted from the double-differential cross section as a function of x and Q{sup 2}. The running beauty-quark mass, m{sub b} at the scale m{sub b}, was determined from a QCD fit at next-to-leading order to HERA data for the first time and found to be m{sub b}(m{sub b})=4.07±0.14(fit){sup +0.01}{sub -0.07} (mod.){sup +0.05}{sub -0.00}(param.){sup +0.08}{sub -0.05}(theo) GeV.

  13. Theoretical Framework and Model Design for Beautiful Countryside Construction in China

    Directory of Open Access Journals (Sweden)

    ZHENG Xiang-qun

    2015-04-01

    Full Text Available In the context of China today, the process of beautiful countryside construction mainly imitates the patterns of‘urbanization’construction. However, this approach leads to the loss of countryside characteristics and the separation of agricultural culture. Therefore, it's urgent to carry out research of the theoretical framework and model design for beautiful countryside construction. In this paper, based on the analysis of the beautiful countryside construction connotation, the basic theory of beautiful countryside construction was summarized in three aspects: rural complex ecosystem model, multi-functionality of rural model and sustainable development evaluation model. The basic idea of the beautiful countryside construction mode was studied. The design method of beautiful countryside construction mode was proposed in three levels: planning, scheming and evaluating. The research results might offer scientific reference for improving the scientific and operational nature of beautiful countryside construction.

  14. pH-Responsive therapeutic solid lipid nanoparticles for reducing P-glycoprotein-mediated drug efflux of multidrug resistant cancer cells

    Directory of Open Access Journals (Sweden)

    Chen HH

    2015-08-01

    enhanced passive tumor accumulation due to the loose intercellular junctions of endothelial cells lining inside blood vessels at tumor site, and the lack of lymphatic drainage. The growth of MCF-7/MDR xenografted tumor on Balb/c nude mice was inhibited to ~400 mm3 in volume as compared with the free DOX treatment group, 1,140 mm3, and the group treated with 1,2 distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol] solid lipid nanoparticles, 820 mm3. Analysis of the body weight of nude mice and the histology of organs and tumor after the administration of DOX-loaded SLNs show that the SLNs have no observable side effects. These results indicate that the C-PEG-SLN is a promising platform for the delivery of therapeutic agents for MDR cancer chemotherapy. Keywords: pH-responsive, solid lipid nanoparticles, multidrug resistance, permeability glycoprotein

  15. Beauty and conservation: a metaphysical, pedagogical and ecclesiastical perspective

    Directory of Open Access Journals (Sweden)

    Mauro Mantovani

    2014-02-01

    Full Text Available After considering the notions of technology, art and culture, this essay presents a brief study on the metaphysical concept of beauty referring particularly to the thought of Thomas Aquinas and then proposing its application in an anthropological-pedagogical sphere. Focus then moves onto the philosophical concept of “conservation”. In this way the paper intends to show how Christian thought has necessarily deepened – in the light of the fundamental notions that belong to it – both the meaning of beauty, the artistic one included, and the concept of conservation and how these perspectives can represent in some way an interesting contribution for those who work in the field of conservation sciences or in the field of the planning and promotion of artistic and cultural events, especially if these events relate to religious heritage.

  16. The beautiful invisible creativity, imagination, and theoretical physics

    CERN Document Server

    Vignale, Giovanni

    2011-01-01

    Challenging the image of theoretical physics as a dry discipline, The Beautiful Invisible shows that this highly abstract science is in fact teeming with beautiful concepts, and the task of imagining them demands profound creativity, just as creative as the work of poets or magical realist novelists such as Borges and Musil. "A good scientific theory is like a symbolic tale, an allegory of reality," writes Giovanni Vignale, as he uncovers the unexpected links between theoretical physics and artistic creativity. In engaging and at times poetic prose, and with ample quotations from many of the writers he admires, Vignale presents his own unorthodox accounts of fundamental theoretical concepts such as Newtonian mechanics, superconductivity, and Einstein's theory of relativity, illuminating their profound implications. Throughout, the author treats readers to glimpses of physics as "exercised in the still night, when only the moon rages." Indeed, as we delve behind now-familiar concepts such as "electron spin" an...

  17. Physics analysis tools for beauty physics in ATLAS

    Energy Technology Data Exchange (ETDEWEB)

    Anastopoulos, C [Physics Department, Aristotle University Of Thessaloniki (Greece); Bouhova-Thacker, E; Catmore, J; Mora, L de [Department of Physics, Lancaster University (United Kingdom); Dallison, S [Particle Physics Department, CCLRC Rutherford Appleton Laboratory (United Kingdom); Derue, F [LPNHE, IN2P3 - CNRS - Universites Paris VI et Paris VII (France); Epp, B; Jussel, P [Institute for Astro- and Particle Physics, University of Innsbruck (Austria); Kaczmarska, A [Institute of Nuclear Physics, Polish Academy of Sciences (Poland); Radziewski, H v; Stahl, T [Department of Physics, University of Siegen (Germany); Reznicek, P [IPNP, Faculty of Mathematics and Physics, Charles University in Prague (Czech Republic)], E-mail: pavel.reznicek@cern.ch

    2008-07-15

    The Large Hadron Collider experiments will search for physics phenomena beyond the Standard Model. Highly sensitive tests of beauty hadrons will represent an alternative approach to this research. The analysis of complex decay chains of the beauty hadrons have to efficiently extract the detector tracks made by these reactions and reject other events in order to make sufficiently precise measurement. This places severe demands on the software used to analyze the B-physics data. The ATLAS B-physics group has written a series of tools and algorithms for performing these tasks, to be run within the ATLAS offline software framework Athena. This paper describes this analysis suite, paying particular attention to mechanisms for handling combinatorics, interfaces to secondary vertex fitting packages, B-flavor tagging tools and finally Monte Carlo true information association to pursue simulation data in process of the software validations which is an important part of the development of the physics analysis tools.

  18. Penta-Quark States with Strangeness, Hidden Charm and Beauty

    Science.gov (United States)

    Wu, Jia-Jun; Zou, Bing-Song

    The classical quenched quark models with three constituent quarks provide a good description for the baryon spatial ground states, but fail to reproduce the spectrum of baryon excited states. More and more evidences suggest that unquenched effects with multi-quark dynamics are necessary ingredients to solve the problem. Several new hyperon resonances reported recently could fit in the picture of penta-quark states. Based on this picture, some new hyperon excited states were predicted to exist; meanwhile with extension from strangeness to charm and beauty, super-heavy narrow N* and Λ* resonances with hidden charm or beauty were predicted to be around 4.3 and 11 GeV, respectively. Recently, two of such N* with hidden charm might have been observed by the LHCb experiment. More of those states are expected to be observed in near future. This opens a new window in order to study hadronic dynamics for the multi-quark states.

  19. Penta-quark States with Strangeness, Hidden Charm and Beauty

    CERN Document Server

    Wu, Jia-Jun

    2015-01-01

    The classical quenched quark models with three constituent quarks provide a good description for the baryon spatial ground states, but fail to reproduce the spectrum of baryon excited states. More and more evidences suggest that unquenched effects with multi-quark dynamics are necessary ingredients to solve the problem. Several new hyperon resonances reported recently could fit in the picture of penta-quark states. Based on this picture, some new hyperon excited states were predicted to exist; meanwhile with extension from strangeness to charm and beauty, super-heavy narrow $N^*$ and $\\Lambda^*$ resonances with hidden charm or beauty were predicted to be around 4.3 and 11 GeV, respectively. Recently, two of such $N^*$ with hidden charm might have been observed by the LHCb experiment. More of those states are expected to be observed in near future. This opens a new window in order to study hadronic dynamics for the multi-quark states.

  20. Perceived beauty of random texture patterns: A preference for complexity.

    Science.gov (United States)

    Friedenberg, Jay; Liby, Bruce

    2016-07-01

    We report two experiments on the perceived aesthetic quality of random density texture patterns. In each experiment a square grid was filled with a progressively larger number of elements. Grid size in Experiment 1 was 10×10 with elements added to create a variety of textures ranging from 10%-100% fill levels. Participants rated the beauty of the patterns. Average judgments across all observers showed an inverted U-shaped function that peaked near middle densities. In Experiment 2 grid size was increased to 15×15 to see if observers preferred patterns with a fixed density or a fixed number of elements. The results of the second experiment were nearly identical to that of the first showing a preference for density over fixed element number. Ratings in both studies correlated positively with a GIF compression metric of complexity and with edge length. Within the range of stimuli used, observers judge more complex patterns to be more beautiful.

  1. Parent-Offspring Conflict over Mating: The Case of Beauty

    Directory of Open Access Journals (Sweden)

    Menelaos Apostolou

    2008-04-01

    Full Text Available In pre-industrial societies parents exercise a strong influence over the mating decisions of their offspring. As modern pre-industrial societies approximate the way of life in ancestral human societies, human mating behavior should be seen as the outcome of a co-evolutionary process between parental and offspring's mating choice. Both parents and offspring have evolved mating preferences, which enable them to select those mates and in-laws who maximize their inclusive fitness. Following Trivers' (1974 theory of parent-offspring conflict, it is hypothesized that in-law and mating preferences substantially overlap, but also differ with respect to the beauty trait of a mating candidate. This hypothesis is tested on a sample of 292 parents. It is found that the two sets of preferences are strongly correlated, while beauty is preferred significantly more in a mating partner than in an in-law.

  2. Hidden-Beauty Charged Tetraquarks and Heavy Quark Spin Conservation

    CERN Document Server

    Ali, A; Polosa, A D; Riquer, V

    2014-01-01

    Assuming the dominance of the spin-spin interaction in a diquark, we point out that the mass differences in the beauty sector M(Z_b') - M(Z_b) scale with quark masses as expected in QCD, with respect to the corresponding mass difference M(Z_c') - M(Z_c). Notably, we show that the decays Upsilon(10890) --> (h_b(1P), h_b(2P)) pi pi are compatible with heavy-quark spin conservation once the contributions of Z_b,Z_b' intermediate states are taken into account, Upsilon(10890) being either a Upsilon(5S) or the beauty analog of Y_c(4260).

  3. Picture of Beautiful Women with Flowers in Their Hair

    Institute of Scientific and Technical Information of China (English)

    1996-01-01

    The painting Picture of Beautiful Women with Flowers in Their Hair is attributed by some to Zhou Fang—a well-known painter of figures in the Tang Dynasty. Painted on silk, this 46×180 cm work depicts some of the aspects of the luxurious lives of noble women during the reign of Li Kuo, an emperor of the Tang Dynasty. The painter, by employing fine lines and deep colors, creates a leisurely and carefree mood. In this scene, a group of beautiful women, five mistresses and one servant girl, are playing with dogs, catching butterflies, and enjoying the flowers on a walk in rate spring. The noble women are dressed in gorgeous silk

  4. Beautiful Teams Inspiring and Cautionary Tales from Veteran Team Leaders

    CERN Document Server

    Stellman, Andrew

    2009-01-01

    What's it like to work on a great software development team facing an impossible problem? How do you build an effective team? Beautiful Teams takes you behind the scenes with some of the most interesting teams in software engineering history. You'll learn from veteran team leaders' successes and failures, told through a series of engaging personal stories -- and interviews -- by leading programmers, architects, project managers, and thought leaders.

  5. Beauty and charm production from Fermilab experiment 789

    Energy Technology Data Exchange (ETDEWEB)

    Jansen, D.M.; Boissevain, J.; Carey, T.A.; Jeppesen, R.G.; Kapustinsky, J.S.; Lane, D.W.; Leitch, M.J.; Lillberg, J.W.; McGaughey, P.L.; Moss, J.M.; Peng, J.C. [Los Alamos National Lab., NM (United States); Brown, G.; Isenhower, L.D.; Keyser, J.; Sadler, M.E.; Schnathorst, R.; Schwindt, R. [Abilene Christian Univ., TX (United States); Gidal, G.; Ho, P.M.; Kowitt, M.S.I.; Luk, K.B.; Pripstein, D. [Lawrence Berkeley Lab., CA (United States); Lederman, L.M.; Schub, M.H. [Chicago Univ., IL (United States); Brown, C.N.; Cooper, W.E.; Glass, H.D.; Gounder, K.N.; Mishra, C.S. [Fermi National Accelerator Lab., Batavia, IL (United States); Kaplan, D.M.; Luebke, W.R.; Martin, V.M.; Preston, R.S.; Sa, J.; Tanikella, V. [Northern Illinois Univ., De Kalb, IL (United States); Childers, R.; Darden, C.W.; Snodgrass, D.; Wilson, J.R. [South Carolina Univ., Columbia, SC (United States); Chen, Y.C. [Academia Sinica, Taipei (Taiwan, Province of China). Inst. of Physics]|[National Cheng Kung Univ., Tainan (Taiwan, Province of China). Inst. of Physics; Kiang, G.C.; Teng, P.K. [Academia Sinica, Taipei (Taiwan, Province of China). Inst. of Physics

    1993-06-01

    Experiment 789 is a fixed-target experiment at Fermilab designed to study low-multiplicity decays of charm and beauty. During the 1991 run. E789 collected {approx} 10{sup 9} events using an 800 GeV proton beam incident upon gold and beryllium targets. Analyses of these data include searches for b {yields} J/{psi}+{Chi} decays and {Alpha}- dependence measurements of neutral D meson production. Preliminary results from the 1991 run are presented in this paper.

  6. Thailand, A beauty hub for everyone? : Internationalizing Thai Aesthetic Surgery

    OpenAIRE

    2008-01-01

    Introduction: Aesthetic surgery becomes another option of beauty. Interested Patients seeking for choices offered outside their homeland for more benefits. Thailand maybe one of those choices people is now interested in. Thai aesthetic industry may prove to be one of the most wanted destinations because of its expertise and relatively low cost with impressive service. Problem: “How should Thailand improve its Aesthetic service attractiveness to drive its potential to the level of internationa...

  7. Lifetime unbiased beauty and charm triggers at LHCb

    CERN Document Server

    Kenzie, Matthew William

    2016-01-01

    This note describes the use of lifetime unbiased triggers in LHCb's High Level Trigger system, implemented during Run 2 of LHC data collection. This is the first time such a strategy has been employed to exclusively trigger on signal candidates in a lifetime unbiased way at a hadron collider. It provides samples of charm and beauty hadrons whose lifetime acceptance due to the trigger requirements is uniform. Consequently, these triggers are suitable for time-dependent measurements and calibration purposes.

  8. Hadron spectroscopy from strangeness to charm and beauty

    Energy Technology Data Exchange (ETDEWEB)

    Zou, B.S., E-mail: zoubs@ihep.ac.cn [State Key Laboratory of Theoretical Physics, Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 100190 (China); Institute of High Energy Physics and Theoretical Physics Center for Science Facilities, Chinese Academy of Sciences, Beijing 100049 (China)

    2013-09-20

    Quarks of different flavors have different masses, which will cause breaking of flavor symmetries of QCD. Flavor symmetries and their breaking in hadron spectroscopy play important role for understanding the internal structures of hadrons. Hadron spectroscopy with strangeness reveals the importance of unquenched quark dynamics. Systematic study of hadron spectroscopy with strange, charm and beauty quarks would be very revealing and essential for understanding the internal structure of hadrons and its underlying quark dynamics.

  9. Construction of compactly supported orthonormal wavelets with beautiful structure

    Institute of Scientific and Technical Information of China (English)

    PENG Lizhong; WANG Yongge

    2004-01-01

    In this paper, a new method of constructing symmetric (antisymmetric) scaling and wavelet filters is introduced, and we get a new type of wavelet system that has very beautiful structure. Using this kind of wavelet system, we can achieve filters with the properties: rational, symmetric or antisymmetric, the lengths of the filters are shorter and the corresponding functions have higher smoothness, so they have good prospect in applications.

  10. Josep Renau and the restoration of a committed beauty.

    OpenAIRE

    Cabañas Bravo, Miguel

    2013-01-01

    Besides the question about the link between beauty and commitment, the paper analyses and proposes the restoration of both the existential and creative trajectory of Josep Renau (Valencia, 1907-Berlin, 1982), as one of the greatest Spanish modern painters without any doubt, but also a most singular, versatile and committed one. He was dedicated to painting, muralist painting, illustration, graphics and posters design or photomontage. His very intense development, in a sort of progression in r...

  11. The beauty of knots at the molecular level.

    Science.gov (United States)

    Sauvage, Jean-Pierre; Amabilino, David B

    2012-01-01

    What makes a given object look beautiful to the observer, be it in the macroscopic world or at the molecular level? This very general question will be briefly addressed at the beginning of this essay, in relation to contemporary molecular chemistry and biology, leading to the general statement that, most of the time, beauty is tightly connected to function as well as to the cultural background of the observer. The main topic of the present article will be that of topologically non-trivial molecules or molecular ensembles and the fascination that such species have exerted on molecular or solid state chemists. Molecules with a graph identical to Kuratowski's K₅ or K₃,₃ graphs are indeed highly attractive from an aesthetical viewpoint, but perhaps even more fascinating and beautiful are molecular knots. A general discussion will be devoted to these compounds, which are still considered as exotic species because of the very limited number of efficient synthetic strategies leading to their preparation. Particularly efficient are templated approaches based either on transition metals such as copper(I) or on organic groups able to form hydrogen bonds or acceptor-donor stacks. A particularly noteworthy property of knots, and in particular of the trefoil knot, is their topological chirality. The isolation of both enantiomers of the trefoil knot (3₁) could be achieved and showed that such species have fascinating chiroptical properties. Finally, various routes to more complex and beautiful knots than the trefoil knot, which is the simplest non-trivial knot, will be discussed in line with the remarkable ability of transition metals to gather and orient in a very precise fashion several organic components in their coordination spheres, thus leading to synthetic precursors displaying geometries which are perfectly well adapted to the preparation of the desired knots or links.

  12. Spectroscopy of onia and hadrons with open beauty in ATLAS

    CERN Document Server

    Henderson, RCW; The ATLAS collaboration

    2015-01-01

    Results published by the ATLAS experiment at the LHC are presented. The ATLAS discovery of the $\\chi_b(3P)$ onia state is recalled and report the new observation of an excited open beauty hadronic state, a $B_c^{\\pm}$ meson with mass $6842 \\pm 4(stat) \\pm 5(syst)$ MeV consistent with expectations for the $B_c^{\\pm}(2S)$.

  13. Sleeping Beauty: Awakening Urothelium from its Slumber.

    Science.gov (United States)

    Balsara, Zarine R; Li, Xue

    2017-01-25

    The bladder urothelium is essentially quiescent but regenerates readily upon injury. The process of urothelial regeneration harkens back to the process of urothelial development whereby urothelial stem/progenitor cells must proliferate and terminally differentiate to establish all three urothelial layers. How the urothelium regulates the level of proliferation and the timing of differentiation to ensure the precise degree of regeneration is of significant interest in the field. Without a carefully-orchestrated process, urothelial regeneration may be inadequate, thereby exposing the host to toxins or pathogens, or excessive, thereby setting the stage for tumor development. This review describes our current understanding of urothelial regeneration. The current controversies surrounding the identity and location of urothelial progenitor cells which mediate urothelial regeneration are discussed and evidence for each model is provided. We emphasize the factors which have been shown to be crucial for urothelial regeneration, including local growth factors which stimulate repair and epithelial-mesenchymal crosstalk which ensures feedback regulation. Also highlighted is the emerging concept of epigenetic regulation of urothelial regeneration which additionally fine tunes the process through transcriptional regulation of cell cycle genes and growth and differentiation factors. Finally, we emphasize how several of these pathways and/or programs are often dysregulated during malignant transformation, further corroborating their importance in directing normal urothelial regeneration. Together, evidence in the field suggests that any attempt to exploit regenerative programs for the purposes of enhanced urothelial repair or replacement must take into account this delicate balance.

  14. Measurement of open beauty production in photoproduction at HERA

    CERN Document Server

    Breitweg, J; Derrick, Malcolm; Krakauer, D A; Magill, S; Musgrave, B; Pellegrino, A; Repond, J; Stanek, R; Yoshida, R; Mattingly, M C K; Antonioli, P; Bari, G; Basile, M; Bellagamba, L; Boscherini, D; Bruni, A; Bruni, G; Cara Romeo, G; Cifarelli, Luisa; Cindolo, F; Contin, A; Corradi, M; De Pasquale, S; Giusti, P; Iacobucci, G; Levi, G; Margotti, A; Massam, Thomas; Nania, R; Palmonari, F; Pesci, A; Sartorelli, G; Zichichi, A; Aghuzumtsyan, G; Amelung, C; Brock, I; Coboken, K; Goers, S; Hartmann, H; Heinloth, K; Hilger, E; Irrgang, P; Jakob, H P; Kappes, A; Katz, U F; Kerger, R; Kind, O; Paul, E; Rautenberg, J; Schnurbusch, H; Stifutkin, A; Tandler, J; Voss, K C; Weber, A; Wieber, H; Bailey, D S; Barret, O; Brook, N H; Cole, J E; Foster, B; Heath, G P; Heath, H F; Robins, S A; Rodrigues, E; Scott, J; Tapper, R J; Capua, M; Mastroberardino, A; Schioppa, M; Susinno, G; Jeoung, H Y; Kim, J Y; Lee, J H; Lim, I T; Ma, K J; Pac, M Y; Caldwell, A; Liu, W; Liu, X; Mellado, B; Paganis, S; Sampson, S; Schmidke, W B; Sciulli, F; Chwastowski, J; Eskreys, Andrzej; Figiel, J; Klimek, K H; Olkiewicz, K; Piotrzkowski, K; Przybycien, M B; Stopa, P; Zawiejski, L; Bednarek, B; Jelen, K; Kisielewska, D; Kowal, A M; Kowalski, T; Rulikowska-Zarebska, E; Suszycki, L; Szuba, D; Bauerdick, L A T; Behrens, U; Bienlein, J K; Borras, K; Chiochia, V; Crittenden, James Arthur; Dannheim, D; Desler, K; Drews, G; Fox-Murphy, A; Fricke, U; Göbel, F; Göttlicher, P; Graciani, R; Haas, T; Hain, W; Hartner, G F; Hebbel, K; Hillert, S; Koch, W; Kötz, U; Kowalski, H; Labes, H; Löhr, B; Mankel, R; Martens, J; Martínez, M; Milite, M; Moritz, M; Notz, D; Petrucci, M C; Polini, A; Rohde, M; Savin, A A; Schneekloth, U; Selonke, F; Sievers, M; Stonjek, S; Wolf, G; Wollmer, U; Youngman, C; Zeuner, W; Coldewey, C; López-Duran-Viani, A; Meyer, A; Schlenstedt, S; Straub, P B; Barbagli, G; Gallo, E; Parenti, A; Pelfer, P G; Bamberger, Andreas; Benen, A; Coppola, N; Eisenhardt, S; Markun, P; Raach, H; Wölfle, S; Bussey, Peter J; Bell, M; Doyle, A T; Glasman, C; Lee, S W; Lupi, A; MacDonald, N; McCance, G J; Saxon, D H; Sinclair, L E; Skillicorn, Ian O; Waugh, R; Bodmann, B; Gendner, N; Holm, U; Salehi, H; Wick, K; Yildirim, A; Carli, T; Garfagnini, A; Geiser, A; Gialas, I; Kcira, D; Klanner, Robert; Lohrmann, E; Goncalo, R; Long, K R; Miller, D B; Tapper, A D; Walker, R; Cloth, P; Filges, D; Ishii, T; Kuze, M; Nagano, K; Tokushuku, K; Yamada, S; Yamazaki, Y; Boos, E G; Pokrovskiy, N S; Zhautykov, B O; Barakbaev, A N; Ahn, S H; Lee, S B; Park, S K; Lim, H; Son, D; Barreiro, F; García, G; González, O; Labarga, L; Del Peso, J; Redondo, I; Terron, J; Vázquez, M E; Barbi, M S; Corriveau, F; Padhi, S; Stairs, D G; Wing, M; Tsurugai, T; Antonov, A; Bashkirov, V; Danilov, M V; Dolgoshein, B A; Gladkov, D; Sosnovtsev, V V; Suchkov, S; Dementiev, R K; Ermolov, P F; Golubkov, Yu A; Katkov, I I; Khein, L A; Korotkova, N A; Korzhavina, I A; Kuzmin, V A; Lukina, O Yu; Proskuryakov, A S; Shcheglova, L M; Solomin, A N; Vlasov, N N; Zotkin, S A; Bokel, C; Botje, M; Brümmer, N; Engelen, J; Grijpink, S; Koffeman, E; Kooijman, P M; Schagen, S; Van Sighem, A; Tassi, E; Tiecke, H G; Tuning, N; Velthuis, J J; Vossebeld, Joost Herman; Wiggers, L; De Wolf, E; Bylsma, B; Durkin, L S; Gilmore, J; Ginsburg, C M; Kim, C L; Ling, T Y; Boogert, S; Cooper-Sarkar, A M; Devenish, R C E; Grosse-Knetter, J; Matsushita, T; Ruske, O; Sutton, M R; Walczak, R; Bertolin, A; Brugnera, R; Carlin, R; Dal Corso, F; Dusini, S; Limentani, S; Longhin, A; Posocco, M; Stanco, L; Turcato, M; Adamczyk, L; Iannotti, L; Oh, B Y; Okrasinski, J R; Saull, P R B; Toothacker, W S; Whitmore, J J; Iga, Y; D'Agostini, Giulio; Marini, G; Nigro, A; Cormack, C; Hart, J C; McCubbin, N A; Shah, T P; Epperson, D E; Heusch, C A; Sadrozinski, H F W; Seiden, A; Wichmann, R; Williams, D C; Park, I H; Pavel, N; Abramowicz, H; Dagan, S; Gabareen, A; Kananov, S; Kreisel, A; Levy, A; Abe, T; Fusayasu, T; Kohno, T; Umemori, K; Yamashita, T; Hamatsu, R; Hirose, T; Inuzuka, M; Kitamura, S; Matsuzawa, K; Nishimura, T; Arneodo, M; Cartiglia, N; Cirio, R; Costa, M; Ferrero, M I; Maselli, S; Monaco, V; Peroni, C; Ruspa, M; Sacchi, R; Solano, A; Staiano, A; Bailey, D C; Fagerstroem, C P; Galea, R; Koop, T; Levman, G M; Martin, J F; Mirea, A; Sabetfakhri, A; Butterworth, J M; Gwenlan, C; Hayes, M E; Heaphy, E A; Jones, T W; Lane, J B; West, B J; Ciborowski, J; Ciesielski, R; Grzelak, G; Nowak, R J; Pawlak, J M; Pawlak, R; Smalska, B; Tymieniecka, T; Wróblewski, A K; Zakrzewski, J A

    2001-01-01

    The production and semi-leptonic decay of heavy quarks have been studied in the photoproduction process $e^+p -> e^+ + {dijet} + e^- + X with the ZEUS detector at HERA using an integrated luminosity of 38.5 ${\\rm pb^{-1}}$. Events with photon-proton centre-of-mass energies, $W_{\\gamma p}$, between 134 and 269 GeV and a photon virtuality, Q^2, less than 1 ${\\rm GeV^2}$ were selected requiring at least two jets of transverse energy $E_T^{\\rm jet1(2)} >7(6)$ GeV and an electron in the final state. The electrons were identified by employing the ionisation energy loss measurement. The contribution of beauty quarks was determined using the transverse momentum of the electron relative to the axis of the closest jet, $p_T^{\\rm rel}$. The data, after background subtraction, were fit with a Monte Carlo simulation including beauty and charm decays. The measured beauty cross section was extrapolated to the parton level with the b quark restricted to the region of transverse momentum $p_T^{b} > p_T^{\\rm min} =$ 5 GeV and ...

  15. Longing for Clouds - Does Beautiful Weather have to be Fine?

    Directory of Open Access Journals (Sweden)

    Mădălina Diaconu

    2016-01-01

    Full Text Available Any attempt to outline a meteorological aesthetics centered on so-called beautiful weather has to overcome several difficulties: In everyday life, the appreciation of the weather is mostly related to practical interests or reduced to the ideal of stereotypical fine weather that is conceived according to blue-sky thinking irrespective of climate diversity. Also, an aesthetics of fine weather seems, strictly speaking, to be impossible given that such weather conditions usually allow humans to focus on aspects other than weather, which contradicts the autotelic character of beauty. The unreflective equation of beautiful weather with moderately sunny weather and a cloudless sky also collides with the psychological need for variation: even living in a “paradisal” climate would be condemned to end in monotony. Finally, whereas fine weather is related in modern realistic literature to cosmic harmony and a universal natural order, contemporary literary examples show that in the age of the climate change, fine weather may be deceitful and its passive contemplation, irresponsible. This implies the necessity of a reflective aesthetic attitude on weather, as influenced by art, literature, and science, which discovers the poetics of bad weather and the wonder that underlies average weather conditions.

  16. New Observations of beauty baryon decays at LHCb

    CERN Document Server

    Vitaly, Andreev

    2014-01-01

    This report describes the work I have done during my summer student association with the LHCb (Large Hadron Collider Beauty Experiment) collaboration at CERN from 30.06 till 26.09.2014. The project was performed in a team with two other summer students. In this report I concentrate on my contribution to the team work. In addition, one section is dedicated to the management framework called “scrum” which we used to collaborate as a team. The goal of my task was to analyze yet unobserved decays of the beauty Lambda-b-0 baryon. This is interesting since the CP violation still remains unobserved in baryons and beauty baryons are generally not well-known yet. LHCb is the first detector where these heavy baryons can be analyzed in detail. In addition these decays may play an important role in other processes and one can gain new insights into the strong interaction. The analysis presented here was performed on the full 2011-2012 LHC run data and includes several decays which are observed for the first time.

  17. Beauty and healing: examining sociocultural expectations of the embodied goddess.

    Science.gov (United States)

    Yeh, Jin-Tsann; Lin, Chyong-Ling

    2013-03-01

    Studies indicate mental health improvement can occur via religious communities offering social support and other resources. Many people from many cultures regard medicine as a supernatural or magical treatment that can somehow lead to a better state of living. In medical advertising, female role portrayal involves the blending of beauty, ritual and attractiveness in combination with the best product image. A Chinese saying suggests that, "A girl will doll herself up for him who loves her." Female role attraction is a very important ethical subject in gender issues. Moving forward in time, female role visualization and consumption in medical advertising reveal depictions that encouraged women to do some self-searching and find, or develop, inner strength. This study is designed to examine female role portrayals in a restricted patriarchal society. The results indicate that the ideology of motherhood is an accepted social orientation that the public readily identifies with. Results further indicate that beautification through medical products incorporates an emotional element of religious healing and that the objectification of beauty in the media reveals a possible neglect of women's internal beauty.

  18. What is beautiful is good because what is beautiful is desired: physical attractiveness stereotyping as projection of interpersonal goals.

    Science.gov (United States)

    Lemay, Edward P; Clark, Margaret S; Greenberg, Aaron

    2010-03-01

    The authors posit that the attribution of desirable interpersonal qualities to physically attractive targets is a projection of interpersonal goals; people desire to form and maintain close social bonds with attractive targets and then project these motivations onto those targets. Three studies support this model. Tendencies to see attractive novel targets depicted in photographs (Study 1), attractive romantic partners (Study 2), and attractive friends (Study 3) as especially interpersonally receptive and responsive were explained by perceivers' heightened desires to bond with attractive individuals. Additional findings regarding response latencies (Study 1) also supported this model. Many instances of the "beautiful is good" effect may not reflect stereotyping as it is typically construed. Rather, they may reflect projection of heightened desires to bond with beautiful people.

  19. Directed altruistic living donation: what is wrong with the beauty contest?

    Science.gov (United States)

    Moorlock, Greg

    2015-11-01

    This paper explores the specific criticism of directed altruistic living organ donation that it creates a 'beauty contest' between potential recipients of organs. The notion of the beauty contest in transplantation was recently used by Neidich et al who stated that '[a]ltruism should be the guiding motivation for all donations, and when it [is], there is no place for a beauty contest'. I examine this beauty contest objection from two perspectives. First, I argue that, when considered against the behaviour of donors, this objection cannot be consistently raised without also objecting to other common aspects of organ donation. I then explore the beauty contest objection from the perspective of recipients, and argue that if the beauty contest is objectionable, it is because of a tension between recipient behaviour and the altruism that supposedly underpins the donation system. I conclude by briefly questioning the importance of this tension in light of the organ shortage.

  20. Measurement of beauty quark mass at HERA and impact on Higgs production in association with beauty quarks at LHC

    CERN Document Server

    Gizhko, Andrii; Foster, Brian

    2016-01-01

    Three different, but related topics are the subject of this thesis, performed in the contextof the ZEUS and CMS groups at DESY. The first measurement of the MS beauty-quarkmass mb (mb ) at an electron-proton collider is presented. The measurement is based ona QCD analysis of beauty production cross sections in deep inelastic (DIS) ep scatteringmeasured by ZEUS at HERA, together with inclusive DIS HERA data, using Next-toLeading-Order QCD predictions. The measured value of the running beauty-quark massin the MS scheme was found to bemb (mb ) = 4.07 ± 0.14 (fit)+0.01 (mod.)+0.05 (param.) +0.08 (theo.) GeV, which is in good−0.07−0.00−0.05agreement with the world average Particle Data Group value and previous measurementsat electron-positron colliders. It is also found to be consistent with the expected runningof mb (µ).A first measurement of the charm-quark mass mc (µ) running in the MS scheme ispresented. The measurement is based on a QCD analysis of the published H1 and ZEUScombination of charm cr...

  1. Socio-economic Conditions of Tribal Female Workers of the Beauty Parlors in Bangladesh

    OpenAIRE

    Nargis Akhter; Feroz Ahmed; Sohrab Hossain

    2011-01-01

    The study highlights the socio-economic conditions of tribal female workers of the beauty parlors in Bangladesh. The study consists of 240 sample tribal female workers of the different beauty parlors situated in six divisional towns of Bangladesh and judgment sampling technique was used to select this sample. The study reveals that tribal women working at beauty parlor draw competitively higher salary than other tribal people; they live at a comparatively healthy physical environment provided...

  2. Germline transgenesis in rabbits by pronuclear microinjection of Sleeping Beauty transposons.

    Science.gov (United States)

    Ivics, Zoltán; Hiripi, László; Hoffmann, Orsolya I; Mátés, Lajos; Yau, Tien Yin; Bashir, Sanum; Zidek, Vaclav; Landa, Vladimír; Geurts, Aron; Pravenec, Michal; Rülicke, Thomas; Bösze, Zsuzsanna; Izsvák, Zsuzsanna

    2014-04-01

    The laboratory rabbit (Oryctolagus cuniculus) is widely used as a model for a variety of inherited and acquired human diseases. In addition, the rabbit is the smallest livestock animal that is used to transgenically produce pharmaceutical proteins in its milk. Here we describe a protocol for high-efficiency germline transgenesis and sustained transgene expression in rabbits by using the Sleeping Beauty (SB) transposon system. The protocol is based on co-injection into the pronuclei of fertilized oocytes of synthetic mRNA encoding the SB100X hyperactive transposase together with plasmid DNA carrying a transgene construct flanked by binding sites for the transposase. The translation of the transposase mRNA is followed by enzyme-mediated excision of the transgene cassette from the plasmids and its permanent genomic insertion to produce stable transgenic animals. Generation of a germline-transgenic founder animal by using this protocol takes ∼2 months. Transposon-mediated transgenesis compares favorably in terms of both efficiency and reliable transgene expression with classic pronuclear microinjection, and it offers comparable efficacies (numbers of transgenic founders obtained per injected embryo) to lentiviral approaches, without limitations on vector design, issues of transgene silencing, and the toxicity and biosafety concerns of working with viral vectors.

  3. Germline transgenesis in rodents by pronuclear microinjection of Sleeping Beauty transposons.

    Science.gov (United States)

    Ivics, Zoltán; Mátés, Lajos; Yau, Tien Yin; Landa, Vladimír; Zidek, Vaclav; Bashir, Sanum; Hoffmann, Orsolya I; Hiripi, László; Garrels, Wiebke; Kues, Wilfried A; Bösze, Zsuzsanna; Geurts, Aron; Pravenec, Michal; Rülicke, Thomas; Izsvák, Zsuzsanna

    2014-04-01

    We describe a protocol for high-efficiency germline transgenesis and sustained transgene expression in two important biomedical models, the mouse and the rat, by using the Sleeping Beauty transposon system. The procedure is based on co-injection of synthetic mRNA encoding the SB100X hyperactive transposase, together with circular plasmid DNA carrying a transgene construct flanked by binding sites for the transposase, into the pronuclei of fertilized oocytes. Upon translation of the transposase mRNA, enzyme-mediated excision of the transgene cassettes from the injected plasmids followed by permanent genomic insertion produces stable transgenic animals. Generation of a germline-transgenic founder animal by using this protocol takes ∼3 months. Transposon-mediated transgenesis compares favorably in terms of both efficiency and reliable transgene expression with classic pronuclear microinjection, and it offers comparable efficacies to lentiviral approaches without limitations on vector design, issues of transgene silencing, and the toxicity and biosafety concerns of working with viral vectors.

  4. Evaluation of various anthropometric proportions in Indian beautiful faces: A photographic study

    Directory of Open Access Journals (Sweden)

    Saaransh Kalra

    2015-01-01

    Full Text Available Introduction: The subject of beauty has been the topic of much debate throughout history, and methods for the evaluation of beauty have been the focus of many research projects. The evaluation of beauty is influenced by factors which include various linear measurements, angles, ratios, and proportions. We evaluated several ratios in Indian Population after locating various landmarks on beautiful Indian faces. Aims and Objectives: The aim of the present study was to evaluate various facial proportions of Indian beauties using their frontal photographs in natural head position to establish anthropometric norms in beautiful Indian females. To evaluate whether these values satisfy golden and silver proportions. To compare these values with Caucasian anthropometric norms. Materials and Methods: Frontal photographs of 30 female celebrities were downloaded from the internet. Photographs of only those Indian beauties that have been declared winners of either national or international beauty contests by a designated panel of judges were included in this study. Hardcopy of these photographs was taken in 5 inch by 3.5 inch format, all the measurements done and ratios calculated. Results: Measurements were tabulated and values for various ratios were calculated to establish norms. Coefficient of variation was also evaluated. Conclusion: All the ratios were found to be consistent than others which made it possible to assess beauty objectively rather than arbitrarily. Most of the values did not match the golden and silver proportion. In comparison with Caucasian population, we found that there is significant difference in most of the values.

  5. Should We Genetically Select for the Beauty Norm of Fair Skin?

    Science.gov (United States)

    Marway, Herjeet

    2017-03-21

    Fair skin is often regarded as a beauty ideal in many parts of the world. Genetic selection for non-disease traits may allow reproducers to select fair skin for the purposes of beauty, and may be justified under various procreative principles. In this paper I assess the ethics of genetic selection for fair skin as a beauty feature. In particular, I explore the discriminatory aspects and demands of such selection. Using race and colour hierarchies that many would find objectionable, I argue that selection for beauty that is underpinned by such hierarchies is not a trivial selection. Given this, I claim that we should not make such selections.

  6. Development of Natural Beauty and Its Association with Artistic Beauty%自然美的发展及其与艺术美的关联

    Institute of Scientific and Technical Information of China (English)

    王峰

    2016-01-01

    自然美是美学研究中的一个主要范围,就其字义来说,自然美主要研究自然之美,研究自然的形式、形态的审美内涵,但从其历史发展来考察就会发现,自然美从来不是一种单纯的、孤立存在的美,它总是与人对它的观照方式联系在一起。自然美与艺术美一直处于既联系又矛盾的关系中。在两者的关系上,现代美学家有的认为自然美是艺术美的基础,比如康德和部分浪漫主义者,以及现代实用主义美学家,但大部分美学家认为艺术美是自然美的先决条件,这种观念从自然美的现代确立者黑格尔那里就已经开始了。%Natural beauty is a major aesthetic research scope. Literally, natural beauty mainly concerns about the beauty of nature and study of the aesthetic connotation of form. However, examining its historical development will find that natural beauty has never been a simple, isolated beauty;instead, it is always associated with the way of the people's concern about it. Natural beauty and artistic beauty has been in both contact and contradictory relationship. As to their relationship, some modern aestheticians think that natural beauty is the basis of artistic beauty, such as Kant and some romantic and modern pragmatism aestheticians, but the aestheticians mostly argue that artistic beauty is the prerequisite of natural beauty, which has long been established by Hegel, modern founder of natural beauty.

  7. Sexual selection, redundancy and survival of the most beautiful

    Indian Academy of Sciences (India)

    R D Morris; J A Morris

    2004-09-01

    A model is described of a highly redundant complex organism that has overlapping banks of genes such that each vital function is specified by several different genetic systems. This generates a synergistic profile linking probability of survival to the number of deleterious mutations in the genome. Computer models show that there is a dynamic interaction between the mean number of new deleterious mutations per generation (), the mean number of deleterious mutations in the genome of the population () and percentage zygote survival (Zs). Increased leads to increased and a fall in Zs but it takes several generations before a new equilibrium is reached. If sexual attraction is influenced by the number of deleterious mutations in the genome of individuals then is reduced and Zs increased for any given value of . This fall in and rise in Zs is more marked in polygamous than monogamous mating systems. The model is specified such that deleterious mutations can occur without any observable or measurable effect on function. Thus sexual selection, in this organism, for low levels of deleterious mutations cannot be based on assessment of performance. Instead it is based on a simple symmetrical surface pattern that is flawlessly reproduced by organisms with no deleterious mutations, but is less than perfect, and therefore less attractive, if genetic systems have been deleted. A complex vital task requires a system with a high level of redundancy that acts so that the loss of one component has no observable effect and therefore cannot be used for sexual selection. The reproduction of a beautiful surface pattern also requires a low error, high redundancy genetic system; however, in this case there is advantage if a single deleterious mutation produces a recognisable change. This leads to the conclusion that sexual selection and sexual attraction should be based on beauty rather than utility, and explains the common observation in nature that it is the most beautiful that

  8. Rhinoplasty and its effects on the perception of beauty

    Directory of Open Access Journals (Sweden)

    Chinski, Hernan

    2013-01-01

    Full Text Available Introduction: Experts on nasal cosmetics and nasal surgery agree that aesthetic rhinoplasty leads to overall facial beautification and the perception of youth in patients. This "assumed truth" has never been proven in the international literature. Aim: To examine increases in facial attractiveness ratings after rhinoplasty surgery. Methods: We conducted a study series by choosing 30 female patients on whom we had operated and 25 evaluators in a single blind trial. The evaluators graded the patients' attractiveness before and after surgery. Results: Beauty indices were significantly improved after the operation. Conclusion: According to the third-party evaluation, the patients appeared prettier after undergoing aesthetic rhinoplasty.

  9. Distinctive Design A Practical Guide to a Useful, Beautiful Web

    CERN Document Server

    Dawson, Alexander

    2011-01-01

    Learn to produce a web site that stands out from the crowd One of the web designer's greatest challenges is to create a site distinctive enough to get noticed among the millions of sites already on the web. This book examines the bond between code, content and visuals to guide you through the factors that increase your design's visibility, usability and beauty. Using this practical advice, even web designers who lack strong artistic skills can develop super sites that strengthen the message and stand out from the crowd.Most books focus primarily on graphic design principles; this one shows you

  10. LHCb: searching for New Physics hidden in beauty and charm

    Energy Technology Data Exchange (ETDEWEB)

    T' Jampens, S. [Laboratoire d' Annecy-le-Vieux de Physique des Particules (CNRS/IN2P3 and Universite de Savoie) 9, chemin de Bellevue, BP 110 F-74941 Annecy-le-Vieux Cedex (France)

    2009-02-15

    Our knowledge of the quark-mixing matrix and of CP violation has been tremendously improved thanks to the B factories and Tevatron: the KM mechanism is the dominant source of CP violation at the electroweak scale. LHCb is one of the six experiments being constructed on the Large Hadron Collider accelerator at CERN. It is a next generation of flavor-physics experiments which will perform precision tests of CP violation and study rare phenomena to unveil physics beyond the Standard Model, if any, in the interactions of charm- and beauty-hadron decays. The current build status of the detector is given followed by selected topics of the expected physics reach.

  11. The history of Botulinum toxin: from poison to beauty.

    Science.gov (United States)

    França, Katlein; Kumar, Anagha; Fioranelli, Massimo; Lotti, Torello; Tirant, Michael; Roccia, Maria Grazia

    2017-03-15

    Botulinum toxin, also called the "miracle toxin," is a neurotoxin produced by the bacteria Clostridium botulinum. It is known to block nerve signals that contract muscles resulting in a temporary paralysis of the muscles. Toxins type A and B have been extensively studied and utilized in the realm of beauty and cosmetology. Initially, the toxin gained popularity as a disease-causing "poison". It was only later that it found its way to becoming a must have in modern aesthetic practice. Today, this wonder toxin has proven to be an apt and convenient option in the field of anti-aging medicine.

  12. Gender, Work, and Identity: Beauty Salons in Bogotá

    Directory of Open Access Journals (Sweden)

    Luz Gabriela Arango Gaviria

    2012-12-01

    Full Text Available This article examines hair salons, beauty parlors and barbershops in Bogotá from threeperspectives; first, as a space that offers a variety of services and aesthetic possibilities ina context of high informality and of class, race, and gender inequality; secondly, as workmarked by sexual and social divisions, in terms of both jobs and attention to the clientele,centered around “emotional work”; and thirdly, as a field of both cultural expressionand conflict with ethnic, racial and sexual aspects. Based on fieldwork and on a focus onintersectionality, the article explores these social differences as manifested in these jobswithin the processes of subsistence and professionalization.

  13. The Nazi cosmetic: medicine in the service of beauty.

    Science.gov (United States)

    Efstathiou, Sophia

    2012-09-01

    This paper examines how aesthetic ideals shaped the practice of Nazi medicine. It proposes that Nazi eugenics relied on the conflation of norms of health with norms of beauty determined and performed by Nazi cultures of action. Though theories of biological holism served as vehicles of Nazi ideology, they did so contingently. The anti-totalitarian thinking of biological holist Kurt Goldstein shows that the use of biological holism to promote Nazi ideology was not inevitable. This examination of aesthetic influences on Nazi medicine shows that traditionally speaking 'non-rational' factors shaped the Nazi biomedical program's aims and methods.

  14. Measurement of Beauty Particle Lifetimes and Hadroproduction Cross-Section

    CERN Multimedia

    2002-01-01

    We propose an experimental search for beauty particles produced in fixed target hadronic interactions. The essential feature of the proposed experimental technique is the use of two specially designed pieces of hardware~-~a high precision ``decay detector'' and a fast secondary vertex trigger processor. If these devices perform to our expectations, we should be able to obtain sufficient data sample to address several important physics issues, including measurements of the lifetimes of charged and neutral B~mesons, the B~hadroproduction cross-section, and possibly B$^0$- $ \\bar{B} ^0 $ mixing.

  15. Fearful Symmetry: The Search for Beauty in Modern Physics

    Energy Technology Data Exchange (ETDEWEB)

    Zakrzewski, W J [Department of Mathematical Sciences Science Laboratory, Durham University, South Road, Durham, DH1 3LE (United Kingdom)

    2008-01-11

    It is easy to see beauty in symmetry when we look at buildings like the Taj Mahal or natural objects such as snowflakes; it is much harder to explain to a non-expert the beauty of equations or of symmetry concepts in relativity or in particle theory. Tony Zee achieves this in a remarkable way, while he also manages to make many complicated concepts accessible to a reader who is genuinely interested and who has some basic/school knowledge of physics. To do this he invents various ordinary world analogies and exploits them in a masterful way. I liked, in particular, his analogy for the colour of quarks and the associated SU(3) symmetry provided by adding colour to ice-cream, which does not change its cost. Of course, sometimes real beauty is associated with a small breakdown of symmetry. We are all familiar with this in music or in art. Tony shows that such a breakdown also has a role in physics and that it is often associated with unexpected and very deep and important concepts (parity, CP violation or baryon assymetry). The book is an amazing achievement; although the main focus is on symmetry and beauty the author manages to explain most of the new and relevant concepts of modern physics, from quantum mechanics and relativity to superstrings and superbranes. And he does this with no equations and almost no mathematical symbols. So who is this book intended for? Who will enjoy reading it? Clearly, it will be appreciated by all theoretical physicists, who probably will be primarily impressed by the way the book makes accessible so many very difficult concepts. I was particularly struck by Tony's ability to explain things in simple terms and to find relevant analogies. It will be also greatly enjoyed by the non-specialist but 'interested' reader; (s)he may find some concepts hard to follow but (s)he will get the general gist of the arguments. It will be also be enjoyed by sixth-formers studying physics and quite possibly will attract some of them to

  16. Beauty and beauty-jet measurement via displaced vertices with ALICE in p+p collisions at {radical}(s) = 7 TeV

    Energy Technology Data Exchange (ETDEWEB)

    Kweon, Min Jung [Universitaet Heidelberg Physikalisches Institut, Heidelberg (Germany); Collaboration: ALICE-Collaboration

    2011-07-01

    The measurement of single electrons from heavy flavor hadron decays at RHIC indicates strong coupling of heavy quarks to the medium produced in ultra relativistic heavy-ion collisions. The LHC extends greatly the kinematic range to high transverse momentum which enables new tests of heavy quark jet dynamics. The beauty hadrons and jets containing beauty hadrons have distinctive properties, which allow for their clear identification. We introduce methods to preferentially select electrons from beauty hadron decays by minimum distance of closest approach cuts and by reconstructing secondary vertices. The first analysis applying these techniques in the ALICE experiment for p+p collisions at {radical}(s)=7 TeV is presented. The analysis status of the data from Pb+Pb collisions, which will allow us to understand beauty quark energy loss in the medium, is also reported.

  17. Denying Diversity: Perceptions of Beauty and Social Comparison Processes among Latina, Black, and White Women.

    Science.gov (United States)

    Poran, Maya A.

    2002-01-01

    Investigated Hispanic, black, and white women's conceptions of beauty and perceptions of cultural standards of beauty, noting whether they were engaged in similar social comparison processes (denial of personal disadvantage). Surveys of female college students highlighted major differences in the women's relationships with their bodies and their…

  18. 77 FR 840 - Pricing for America the Beautiful Five Ounce Silver Uncirculated CoinsTM

    Science.gov (United States)

    2012-01-06

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY United States Mint Pricing for America the Beautiful Five Ounce Silver Uncirculated Coins TM AGENCY... announcing the re-pricing of the America the Beautiful Five Ounce Silver Uncirculated Coins. The price of...

  19. 76 FR 65563 - Pricing for America the Beautiful Five Ounce Silver Uncirculated CoinsTM

    Science.gov (United States)

    2011-10-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY United States Mint Pricing for America the Beautiful Five Ounce Silver Uncirculated Coins TM AGENCY... announcing the re-pricing of the America the Beautiful Five Ounce Silver Uncirculated Coins. The price of...

  20. A twentieth-century triangle trade: selling black beauty at home and abroad, 1945–1965.

    Science.gov (United States)

    McAndrew, Malia

    2010-01-01

    This study examines the careers of African American beauty culturists as they worked in the United States, Europe, and Africa between 1945 and 1965. Facing push back at home, African American beauty entrepreneurs frequently sought out international venues that were hospitable and receptive to black Americans in the years following World War II. By strategically using European sites that white Americans regarded as the birthplace of Western fashion and beauty, African American entrepreneurs in the fields of modeling, fashion design, and hair care were able to win accolades and advance their careers. In gaining support abroad, particularly in Europe, these beauty culturists capitalized on their international success to establish, legitimize, and promote their business ventures in the United States. After importing a positive reputation for themselves from Europe to the United States, African American beauty entrepreneurs then exported an image of themselves as the world's premier authorities on black beauty to people of color around the globe as they sold their products and marketed their expertise on the African continent itself. This essay demonstrates the important role that these black female beauty culturists played, both as businesspeople and as race leaders, in their generation's struggle to gain greater respect and opportunity for African Americans both at home and abroad. In doing so it places African American beauty culturists within the framework of transatlantic trade networks, the Black Freedom Movement, Pan-Africanism, and America's Cold War struggle.

  1. 76 FR 17485 - Pricing for America the Beautiful Five Ounce Silver Bullion Coin Presentation Case

    Science.gov (United States)

    2011-03-29

    ... United States Mint Pricing for America the Beautiful Five Ounce Silver Bullion Coin Presentation Case... is announcing the price of the America the Beautiful Five Ounce Silver Bullion Coin Presentation Case. A lot of 25 presentation cases will be offered for sale at a price of $86.95. FOR...

  2. Shaping the Female Student: An Analysis of Swedish Beauty School Recruitment Texts

    Science.gov (United States)

    Bredlöv, Eleonor

    2016-01-01

    This study focuses on the recruitment of adults to the beauty industry in Sweden. It is concerned with a move in (beauty) education away from state and towards private provision in a wider context where education is becoming more heavily marketised. Drawing on a poststructural approach inspired by the work of Foucault and feminist theory, the…

  3. If the Shoe Fits: Virtue and Absolute Beauty in Fairy Tale Drama.

    Science.gov (United States)

    Thompson, Melissa C.

    2000-01-01

    Examines five versions of the Cinderella story. Argues that children's fairy tale drama presents female beauty as a moral absolute, not merely as a physical characteristic. Cites feminist theories of the female body to demonstrate ways in which fairy tale drama establishes female beauty as an unchanging, "universal" concept. Considers…

  4. The Beauty of the Psyche and Eros Myth: Integrating Aesthetics into Introduction to Psychology

    Science.gov (United States)

    Diessner, Rhett; Burke, Kayla

    2011-01-01

    Beginning in the late 1990s the authors became convinced that their undergraduate psychology students needed classroom experiences that set the conditions for them to become more engaged with beauty. They recognized the intrinsic importance of beauty to human psychological development, beyond any utilitarian concerns. But they also believed that…

  5. Angular correlations in beauty production at the Tevatron at Vs=1.96 TeV

    NARCIS (Netherlands)

    Wijngaarden, Daniel Abraham

    2005-01-01

    Graduate student Bram Wijngaarden of the Institute of Mathematics, Astrophysics and Particle Physics has studied the production of beauty quarks at the particle accelerator of Fermilab, near Chicago. Beauty quarks are produced in high-energy particle collisions. By measuring the angle between two be

  6. Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma.

    Science.gov (United States)

    Mann, Karen M; Ward, Jerrold M; Yew, Christopher Chin Kuan; Kovochich, Anne; Dawson, David W; Black, Michael A; Brett, Benjamin T; Sheetz, Todd E; Dupuy, Adam J; Chang, David K; Biankin, Andrew V; Waddell, Nicola; Kassahn, Karin S; Grimmond, Sean M; Rust, Alistair G; Adams, David J; Jenkins, Nancy A; Copeland, Neal G

    2012-04-17

    Pancreatic cancer is one of the most deadly cancers affecting the Western world. Because the disease is highly metastatic and difficult to diagnosis until late stages, the 5-y survival rate is around 5%. The identification of molecular cancer drivers is critical for furthering our understanding of the disease and development of improved diagnostic tools and therapeutics. We have conducted a mutagenic screen using Sleeping Beauty (SB) in mice to identify new candidate cancer genes in pancreatic cancer. By combining SB with an oncogenic Kras allele, we observed highly metastatic pancreatic adenocarcinomas. Using two independent statistical methods to identify loci commonly mutated by SB in these tumors, we identified 681 loci that comprise 543 candidate cancer genes (CCGs); 75 of these CCGs, including Mll3 and Ptk2, have known mutations in human pancreatic cancer. We identified point mutations in human pancreatic patient samples for another 11 CCGs, including Acvr2a and Map2k4. Importantly, 10% of the CCGs are involved in chromatin remodeling, including Arid4b, Kdm6a, and Nsd3, and all SB tumors have at least one mutated gene involved in this process; 20 CCGs, including Ctnnd1, Fbxo11, and Vgll4, are also significantly associated with poor patient survival. SB mutagenesis provides a rich resource of mutations in potential cancer drivers for cross-comparative analyses with ongoing sequencing efforts in human pancreatic adenocarcinoma.

  7. Targeting the central nervous system with herpes simplex virus / Sleeping Beauty hybrid amplicon vectors.

    Science.gov (United States)

    de Silva, Suresh; Bowers, William J

    2011-10-01

    The pursuits of sustainable treatments for diseases and disorders that afflict the central nervous system (CNS) have proven challenging for the field of viral vector-based gene therapy. However, recent advances in viral vector technology coupled with efficient delivery methods have opened up new avenues that show promise at the preclinical testing stage. The development of the Herpes Simplex Virus/Sleeping Beauty (HSV/SB) hybrid vector represents such an advance for devising treatments targeting the CNS with its potential for stably integrating large transgenomic segments of DNA within the genomes of transduced cells. In utero administration of this hybrid vector into the embryonic mouse brain has revealed the capacity for widespread transgene dissemination due to the targeting of a neuronal precursor cell population. This unique feature has provided the means to stably express a transgene throughout the brain for prolonged periods, which is a prerequisite for the treatment of progressive CNS disorders. In this review we provide a comprehensive breakdown of the characteristics of the HSV/SB vector system and how it can be efficiently employed in the derivation of CNS-targeted gene therapeutic strategies.

  8. Feminism Interpretation of the Beauties in American Beauty%解析《美国丽人》中的女性

    Institute of Scientific and Technical Information of China (English)

    田利红

    2012-01-01

    从心理学家荣格的人格原型学说和巴赫金的丑角化理论,展开美国电影《美国丽人》中丽人们的角色剖析,从而对父权制的无形压迫进行了深层次的控诉。%From the perspectives of psychologist C.G.Jung's human psyche and Bakhtin's clown theory probing the female characters in American film American Beauty, it aims to expose and accuse of the invisible oppression of patriarchy system upon women.

  9. Development of new RNAi therapeutics

    OpenAIRE

    LIU, G; Wong-Staal, F; Li, Q. X.

    2007-01-01

    RNAi-mediated gene inactivation has become a cornerstone of the present day gene function studies that are the foundation of mechanism and target based drug discovery and development, which could potentially shorten the otherwise long process of drug development. In particular, the coming of age of “RNAi drug” could provide new promising therapeutics bypassing traditional approaches. However, there are technological hurdles need to overcome and the biological limita...

  10. A tevatron collider beauty factory. [Final report, 1980--1992

    Energy Technology Data Exchange (ETDEWEB)

    1992-12-31

    This document which is labeled a final report consists of several different items. The first is a proposal for a detector to be developed for beauty physics. The detector is proposed for the Fermilab Tevatron, and would be designed to measure mixing reactions, rare decay modes, and even CP violation in hadron collider beauty production. The general outline of the work proposed is given, and an estimate of the time to actually design the detector is presented, along with proposed changes to the Tevatron to accommodate the system. A preliminary report on an experiment to verify a reported observation of a 17 keV neutrino in tritium decay is presented. The present results in the decay spectra actually show a depression below expected levels, which is not consistent with a massive neutrino. Additional interest has been shown in finishing an electrostatic beta spectrometer which was started several years previously. The instrument uses hemispherical electrostatic electric fields to retard electrons emitted in tritium decay, allowing measurement of integral spectra. The design goal has a 5 eV energy resolution, which may be achievable. A new PhD student is pursuing this experiment. Also the report contains a proposal for additional work in the field of non-perturbative quantum field theory by the theoretical group at OU. The work which is proposed will be applied to electroweak and strong interactions, as well as to quantum gravitational phenomena.

  11. Beauty and Body Image Concerns Among African American College Women

    Science.gov (United States)

    Awad, Germine H.; Norwood, Carolette; Taylor, Desire S.; Martinez, Mercedes; McClain, Shannon; Jones, Bianca; Holman, Andrea; Chapman-Hilliard, Collette

    2014-01-01

    The current study examined body image concerns among African American women. In recent years, there has been an attempt to include ethnic minority samples in body image studies (e.g., Grabe & Hyde, 2006; Hrabosky & Grilo, 2007; Lovejoy, 2001) but few specifically examine unique issues pertaining to beauty and body image for African American college age women. A total of 31 African American women participated in one of five focus groups on the campus of a large Southwestern University to examine beauty and body image. Data were analyzed using a thematic approach and several themes were identified. The majority of themes pertained to issues related to hair, skin tone, body type, and message sources. Themes included: sacrifice, ignorance/racial microaggressions, and validation and invalidation by others, thick/toned/curvy as optimal, hypersexualization, and being thin is for White women. Findings of the current study suggest a reconceptualization of body image for African American women where relevant characteristics such as hair and skin tone are given more priority over traditional body image concerns often associated with European American women. PMID:26778866

  12. Hidden-beauty charged tetraquarks and heavy quark spin conservation

    Energy Technology Data Exchange (ETDEWEB)

    Ali, A. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Maiani, L.; Polosa, A.D.; Riquer, V. [Rome-3 Univ. (Italy). Dipt. di Fisica; INFN, Sezione di Roma (Italy)

    2014-12-15

    Assuming the dominance of the spin-spin interaction in a diquark, we point out that the mass differences in the beauty sector M(Z'{sub b}){sup ±}-M(Z{sub b}){sup ±} scale with quark masses as expected in QCD, with respect to the corresponding mass difference M(Z'{sub c}){sup ±}-M(Z{sub c}){sup ±}. Notably, we show that the decays Υ(10890)→(h{sub b}(1P),h{sub b}(2P))π{sup +}π{sup -} are compatible with heavy-quark spin conservation once the contributions of Z{sub b},Z'{sub b} intermediate states are taken into account, Υ(10890) being either a Υ(5S) or the beauty analog of Y{sub c}(4260). We also consider the role of Z{sub b},Z'{sub b} in Υ(10890)→Υ(nS)ππ decays and of light quark spin non-conservation in Z{sub b}, Z'{sub b} decays into BB{sup *} and B{sup *}B{sup *}. Indications on possible signatures of the still missing X{sub b} resonance are proposed.

  13. Hidden-beauty charged tetraquarks and heavy quark spin conservation

    Science.gov (United States)

    Ali, A.; Maiani, L.; Polosa, A. D.; Riquer, V.

    2015-01-01

    Assuming the dominance of the spin-spin interaction in a diquark, we point out that the mass difference in the beauty sector M (Zb')±-M (Zb)± scales with quark masses as expected in QCD, with respect to the corresponding mass difference M (Zc')±-M (Zc)± . Notably, we show that the decays ϒ (10890 )→ϒ (n S )π+π- and ϒ (10890 )→(hb(1 P ),hb(2 P ))π+π- are compatible with heavy quark spin conservation if the contributions of Zb,Zb' intermediate states are taken into account, ϒ (10890 ) being either a ϒ (5 S ) or the beauty analog of Yc(4260 ). Belle results on these decays support the quark spin wave function of the Z states as tetraquarks. We also consider the role of light quark spin nonconservaton in Zb,Zb' decays into B B* and B*B*. Indications of possible signatures of the still missing Xb resonance are proposed.

  14. Decay Constants of Beauty Mesons from QCD Sum Rules

    CERN Document Server

    Lucha, Wolfgang; Simula, Silvano

    2014-01-01

    Our recently completed analysis of the decay constants of both pseudoscalar and vector beauty mesons reveals that in the bottom-quark sector two specific features of the sum-rule predictions show up: (i) For the input value of the bottom-quark mass in the $\\overline{\\rm MS}$ scheme $\\overline{m}_b(\\overline{m}_b)\\approx4.18\\;\\mbox{GeV},$ the sum-rule result $f_B\\approx210$-$220\\;\\mbox{MeV}$ for the $B$ meson decay constant is substantially larger than the recent lattice-QCD finding $f_B\\approx190\\;\\mbox{MeV}.$ Requiring QCD sum rules to reproduce the lattice-QCD value of $f_B$ yields a significantly larger $b$-quark mass: $\\overline{m}_b(\\overline{m}_b)=4.247\\;\\mbox{GeV}.$ (ii) Whereas QCD sum-rule predictions for the charmed-meson decay constants $f_D,$ $f_{D_s},$ $f_{D^*}$ and $f_{D_s^*}$ are practically independent of the choice of renormalization scale, in the beauty sector the results for the decay constants - and especially for the ratio $f_{B^*}/f_B$ - prove to be very sensitive to the specific scale s...

  15. Decay Constants of Beauty Mesons from QCD Sum Rules

    Directory of Open Access Journals (Sweden)

    Lucha Wolfgang

    2014-01-01

    Full Text Available Our recently completed analysis of the decay constants of both pseudoscalar and vector beauty mesons reveals that in the bottom-quark sector two specific features of the sum-rule predictions show up: (i For the input value of the bottom-quark mass in the M̅S̅ scheme m̅b(m̅b ≈ 4:18 GeV; the sum-rule result fB ≈ 210–220 MeV for the B meson decay constant is substantially larger than the recent lattice-QCD finding fB ≈ 190 MeV: Requiring QCD sum rules to reproduce the lattice-QCD value of fB yields a significantly larger b-quark mass: m̅b(m̅b = 4:247 GeV: (ii Whereas QCD sum-rule predictions for the charmed-meson decay constants fD; fDs, fD* and fDs* are practically independent of the choice of renormalization scale, in the beauty sector the results for the decay constants—and especially for the ratio fB* / fB—prove to be very sensitive to the specific scale setting.

  16. The production of knowledge related to body and beauty: implications for physical education

    Directory of Open Access Journals (Sweden)

    Liege Monique Filgueiras da Silva

    2013-06-01

    Full Text Available The text it is a part of a research Masters, held at the Graduate Program in Education of UFRN. To this end, we considered the relationship between the meanings of body and beauty products analyzed and identified in the models of beauty in Physical Education. This research is qualitative in nature, and content analysis for data processing. The corpus of analysis consisted of eight papers in the area of Physical Education, published in the Bank of Capes Thesis from 2004 to 2008, selected from the subject body and beauty. It was observed that the understanding of body and beauty in the area has been re-signified, which represents the development that has occurred in the tract of the body of knowledge and beauty.

  17. On Hanging Laundry: The Place of Beauty in Managing Everyday Life

    Directory of Open Access Journals (Sweden)

    Pauliina Rautio

    2009-01-01

    Full Text Available The data of my empirical research in the field of education discussed in this paper consist of letters produced through correspondence. I asked the participants to write about beauty in their everyday lives, giving substance to the concept as freely as they could. In this paper it is only the letters of one participant, Laura, which I limit my attention to. The aim is to find out what kind of place beauty, as defined and used by herself, holds in the managing of her everyday life. The concept of beauty is virtually missing from educational research or is misguidedly restricted only to formal art education. Beauty being for Laura an occasional checking of direction in relation to changes both in the context of her everyday life and in herself as a person sheds light to the relevance of beauty at the constitutive and perceptual level of growing as a human being.

  18. Thinking on Beautiful Countryside Construction Based on Land Consolidation in Hefei City

    Institute of Scientific and Technical Information of China (English)

    Wei; WANG; Zhongxiang; YU

    2013-01-01

    This paper stated the background under which beautiful countryside construction was proposed;reviewed the new countryside construction profile of Hefei City before beautiful countryside construction was proposed;analyzed the practices of beautiful countryside construction of Hefei City from the perspective of the land consolidation when considering the development of new-type urbanization conjunctively;then,on the basis of the analysis,it proposed a consideration that the land consolidation and beautiful countryside construction practices of Hefei City should be used for reference,that is to say,the city should focus on beautiful countryside construction planning and comprehensively promote the land consolidation.And it also indicated that there were three kinds of relations needed to be treated well and"five combinations"needed to be done well in land consolidation.

  19. Remobilization of Sleeping Beauty transposons in the germline of Xenopus tropicalis

    Directory of Open Access Journals (Sweden)

    Yergeau Donald A

    2011-11-01

    Full Text Available Abstract Background The Sleeping Beauty (SB transposon system has been used for germline transgenesis of the diploid frog, Xenopus tropicalis. Injecting one-cell embryos with plasmid DNA harboring an SB transposon substrate together with mRNA encoding the SB transposase enzyme resulted in non-canonical integration of small-order concatemers of the transposon. Here, we demonstrate that SB transposons stably integrated into the frog genome are effective substrates for remobilization. Results Transgenic frogs that express the SB10 transposase were bred with SB transposon-harboring animals to yield double-transgenic 'hopper' frogs. Remobilization events were observed in the progeny of the hopper frogs and were verified by Southern blot analysis and cloning of the novel integrations sites. Unlike the co-injection method used to generate founder lines, transgenic remobilization resulted in canonical transposition of the SB transposons. The remobilized SB transposons frequently integrated near the site of the donor locus; approximately 80% re-integrated with 3 Mb of the donor locus, a phenomenon known as 'local hopping'. Conclusions In this study, we demonstrate that SB transposons integrated into the X. tropicalis genome are effective substrates for excision and re-integration, and that the remobilized transposons are transmitted through the germline. This is an important step in the development of large-scale transposon-mediated gene- and enhancer-trap strategies in this highly tractable developmental model system.

  20. Germline transgenesis in pigs by cytoplasmic microinjection of Sleeping Beauty transposons.

    Science.gov (United States)

    Ivics, Zoltán; Garrels, Wiebke; Mátés, Lajos; Yau, Tien Yin; Bashir, Sanum; Zidek, Vaclav; Landa, Vladimír; Geurts, Aron; Pravenec, Michal; Rülicke, Thomas; Kues, Wilfried A; Izsvák, Zsuzsanna

    2014-04-01

    The pig has emerged as an important large animal model in biomedical and pharmaceutical research. We describe a protocol for high-efficiency germline transgenesis and sustained transgene expression in pigs by using the Sleeping Beauty (SB) transposon system. The protocol is based on co-injection of a plasmid encoding the SB100X hyperactive transposase, together with a second plasmid carrying a transgene flanked by binding sites for the transposase, into the cytoplasm of porcine zygotes. The transposase mediates excision of the transgene cassette from the plasmid vector and its permanent insertion into the genome to produce stable transgenic animals. This method compares favorably in terms of both efficiency and reliable transgene expression to classic pronuclear microinjection or somatic cell nuclear transfer (SCNT), and it offers comparable efficacies to lentiviral approaches, without limitations on vector design, issues of transgene silencing and the toxicity and biosafety concerns of working with viral vectors. Microinjection of the vectors into zygotes and transfer of the embryos to recipient animals can be performed in 1 d; generation of germline-transgenic lines by using this protocol takes ∼1 year.

  1. Effects of objectifying gaze on female cognitive performance: The role of flow experience and internalization of beauty ideals.

    Science.gov (United States)

    Guizzo, Francesca; Cadinu, Mara

    2016-11-01

    Although previous research has demonstrated that objectification impairs female cognitive performance, no research to date has investigated the mechanisms underlying such decrement. Therefore, we tested the role of flow experience as one mechanism leading to performance decrement under sexual objectification. Gaze gender was manipulated by having male versus female experimenters take body pictures of female participants (N = 107) who then performed a Sustained Attention to Response Task. As predicted, a moderated mediation model showed that under male versus female gaze, higher internalization of beauty ideals was associated with lower flow, which in turn decreased performance. The implications of these results are discussed in relation to objectification theory and strategies to prevent sexually objectifying experiences.

  2. Women online: Characteristics of a “beauty salon talk” in the blog Mão Feita

    Directory of Open Access Journals (Sweden)

    Daniela Silva Agendes

    2011-09-01

    Full Text Available This paper aims to show some characteristicsof female blogs based on the blog Mão Feita,a website about nail polish, written by womenand created in 2008. Some concepts and characteristicsof Computer-Mediated Communicationand blogs are discussed in this article and theyare the foundation of this analysis. It is possibleto characterize the object as a Mixed Publication(Recuero, 2003 and as a fashion blog (Hinerasky,2010 with commercial purpose and evidencesthat indicate professionalism. The article analyzesthe interaction between bloggers and readers,the relationship of support and empathy amongusers and other characteristics of the blog MãoFeita may represent the female discourse in theInternet. Some female issues are also discussed:discursive fragments suggest the demarcation ofa feminine place in this blog, where a “beauty salontalk” happens.

  3. Sleeping beauties cited in patents: Is there also a dormitory of inventions?

    Science.gov (United States)

    van Raan, Anthony F J

    2017-01-01

    A 'Sleeping Beauty in Science' is a publication that goes unnoticed ('sleeps') for a long time and then, almost suddenly, attracts a lot of attention ('is awakened by a prince'). In our foregoing study we found that roughly half of the Sleeping Beauties are application-oriented and thus are potential Sleeping Innovations. In this paper we investigate a new topic: Sleeping Beauties that are cited in patents. In this way we explore the existence of a dormitory of inventions. To our knowledge this is the first study of this kind. We investigate the time lag between publication of the Sleeping Beauty and the first citation by a patent. We find that patent citation may occur before or after the awakening and that the depth of the sleep, i.e., citation rate during the sleeping period, is no predictor for later scientific or technological impact of the Sleeping Beauty. A surprising finding is that Sleeping Beauties are significantly more cited in patents than 'normal' papers. Inventor-author self-citations relations occur only in a small minority of the Sleeping Beauties that are cited in patents, but other types of inventor-author links occur more frequently. We develop an approach in different steps to explore the cognitive environment of Sleeping Beauties cited in patents. First, we analyze whether they deal with new topics by measuring the time-dependent evolution in the entire scientific literature of the number of papers related to both the precisely defined topics as well as the broader research theme of the Sleeping Beauty during and after the sleeping time. Second, we focus on the awakening by analyzing the first group of papers that cites the Sleeping Beauty. Third, we create concept maps of the topic-related and the citing papers for a time period immediately following the awakening and for the most recent period. Finally, we make an extensive assessment of the cited and citing relations of the Sleeping Beauty. We find that tunable co-citation analysis is a

  4. Integration profile and safety of an adenovirus hybrid-vector utilizing hyperactive sleeping beauty transposase for somatic integration.

    Directory of Open Access Journals (Sweden)

    Wenli Zhang

    Full Text Available We recently developed adenovirus/transposase hybrid-vectors utilizing the previously described hyperactive Sleeping Beauty (SB transposase HSB5 for somatic integration and we could show stabilized transgene expression in mice and a canine model for hemophilia B. However, the safety profile of these hybrid-vectors with respect to vector dose and genotoxicity remains to be investigated. Herein, we evaluated this hybrid-vector system in C57Bl/6 mice with escalating vector dose settings. We found that in all mice which received the hyperactive SB transposase, transgene expression levels were stabilized in a dose-dependent manner and that the highest vector dose was accompanied by fatalities in mice. To analyze potential genotoxic side-effects due to somatic integration into host chromosomes, we performed a genome-wide integration site analysis using linker-mediated PCR (LM-PCR and linear amplification-mediated PCR (LAM-PCR. Analysis of genomic DNA samples obtained from HSB5 treated female and male mice revealed a total of 1327 unique transposition events. Overall the chromosomal distribution pattern was close-to-random and we observed a random integration profile with respect to integration into gene and non-gene areas. Notably, when using the LM-PCR protocol, 27 extra-chromosomal integration events were identified, most likely caused by transposon excision and subsequent transposition into the delivered adenoviral vector genome. In total, this study provides a careful evaluation of the safety profile of adenovirus/Sleeping Beauty transposase hybrid-vectors. The obtained information will be useful when designing future preclinical studies utilizing hybrid-vectors in small and large animal models.

  5. 'Are you a woman--or a flower?' The capacity to experience beauty.

    Science.gov (United States)

    Sweetnam, Annie

    2007-12-01

    Being surprised by beauty, being drawn to and moved by it and surrendering to its sensory nature are all part of beauty's emotionally transformative power. And yet, psychoanalysis has had little to say about such an enriching dimension of psychological life. The author highlights how experiencing beauty is a capacity that is not isolated but is part of the lifelong experience of being changed by and changing the experience of the world we live in. She suggests that the capacity to experience beauty takes different forms at distinct points in development and in psychoanalytic treatments. The author describes two clinical occasions from a case where an analytic pair struggled to develop a greater capacity to experience beauty over time. She discusses how a theory of the aesthetic conflict was useful in helping to understand her patient's inner object world but was not sufficient when it came to understanding the experience of beauty. She shows how for both patient and analyst, experiencing beauty's full effect required responding to the call toward emotional life, surrendering to the surprise and the unknown, and letting go of the mind's struggle to find meaning and opening up to transforming and being transformed through sensory experience.

  6. The beauty of physics patterns, principles, and perspectives

    CERN Document Server

    Rau, A R P

    2014-01-01

    The beauty of physics lies in its coherence in terms of a few fundamental concepts and principles. Even physicists have occasion to marvel at the overarching reach of basic principles and their ability to account for features stretching from the microscopic sub-atomic world to the cosmological expanses of the Universe. While mathematics is its natural language, physics is mostly about patterns, connections, and relations between objects and phenomena, and it is this aspect that is emphasized in this book. Since science tries to connect phenomena that at first sight appear widely different, while boiling them down to a small set of essential principles and laws, metaphor and analogy pervade our subject. Consider the pendulum, its swing from one extreme to the other often invoked in social or economic contexts. In molecular vibrations, such as in the CO2 molecule, the quantum motions of electrons and nuclei are metaphorically the pendulums. In electromagnetic radiation, including the visible light we observe, t...

  7. A mathematical tapestry demonstrating the beautiful unity of mathematics

    CERN Document Server

    Hilton, Peter; Donmoyer, Sylvie

    2010-01-01

    This easy-to-read 2010 book demonstrates how a simple geometric idea reveals fascinating connections and results in number theory, the mathematics of polyhedra, combinatorial geometry, and group theory. Using a systematic paper-folding procedure it is possible to construct a regular polygon with any number of sides. This remarkable algorithm has led to interesting proofs of certain results in number theory, has been used to answer combinatorial questions involving partitions of space, and has enabled the authors to obtain the formula for the volume of a regular tetrahedron in around three steps, using nothing more complicated than basic arithmetic and the most elementary plane geometry. All of these ideas, and more, reveal the beauty of mathematics and the interconnectedness of its various branches. Detailed instructions, including clear illustrations, enable the reader to gain hands-on experience constructing these models and to discover for themselves the patterns and relationships they unearth.

  8. CP violation in multibody decays of beauty baryons

    CERN Document Server

    Durieux, Gauthier

    2016-01-01

    Beauty baryons are being observed in large number in the LHCb detector. The rich kinematics of their multibody decays are therefore becoming accessible and provide us with new opportunities to search for CP violation. We analyse the angular distributions of some three- and four-body decays of spin-$1/2$ baryons using the Jacob-Wick helicity formalism. The asymmetries that provide access to small differences of CP-odd phases between decay amplitudes of identical CP-even phases are notably discussed. The understanding gained on processes featuring specific resonant intermediate states allows us to establish which asymmetries are relevant for what purpose. It is for instance shown that some CP-odd angular asymmetries measured by the LHCb collaboration in the $\\Lambda_b \\to \\Lambda\\,\\varphi \\to p\\,\\pi\\, K^+ K^-$ decay are expected to vanish identically.

  9. Identification of beauty and charm quark jets at LHCb

    CERN Document Server

    Aaij, Roel; Adinolfi, Marco; Affolder, Anthony; Ajaltouni, Ziad; Akar, Simon; Albrecht, Johannes; Alessio, Federico; Alexander, Michael; Ali, Suvayu; Alkhazov, Georgy; Alvarez Cartelle, Paula; Alves Jr, Antonio Augusto; Amato, Sandra; Amerio, Silvia; Amhis, Yasmine; An, Liupan; Anderlini, Lucio; Anderson, Jonathan; Andreotti, Mirco; Andrews, Jason; Appleby, Robert; Aquines Gutierrez, Osvaldo; Archilli, Flavio; d'Argent, Philippe; Artamonov, Alexander; Artuso, Marina; Aslanides, Elie; Auriemma, Giulio; Baalouch, Marouen; Bachmann, Sebastian; Back, John; Badalov, Alexey; Baesso, Clarissa; Baldini, Wander; Barlow, Roger; Barschel, Colin; Barsuk, Sergey; Barter, William; Batozskaya, Varvara; Battista, Vincenzo; Bay, Aurelio; Beaucourt, Leo; Beddow, John; Bedeschi, Franco; Bediaga, Ignacio; Bel, Lennaert; Belyaev, Ivan; Ben-Haim, Eli; Bencivenni, Giovanni; Benson, Sean; Benton, Jack; Berezhnoy, Alexander; Bernet, Roland; Bertolin, Alessandro; Bettler, Marc-Olivier; van Beuzekom, Martinus; Bien, Alexander; Bifani, Simone; Bird, Thomas; Birnkraut, Alex; Bizzeti, Andrea; Blake, Thomas; Blanc, Frédéric; Blouw, Johan; Blusk, Steven; Bocci, Valerio; Bondar, Alexander; Bondar, Nikolay; Bonivento, Walter; Borghi, Silvia; Borsato, Martino; Bowcock, Themistocles; Bowen, Espen Eie; Bozzi, Concezio; Braun, Svende; Brett, David; Britsch, Markward; Britton, Thomas; Brodzicka, Jolanta; Brook, Nicholas; Bursche, Albert; Buytaert, Jan; Cadeddu, Sandro; Calabrese, Roberto; Calvi, Marta; Calvo Gomez, Miriam; Campana, Pierluigi; Campora Perez, Daniel; Capriotti, Lorenzo; Carbone, Angelo; Carboni, Giovanni; Cardinale, Roberta; Cardini, Alessandro; Carniti, Paolo; Carson, Laurence; Carvalho Akiba, Kazuyoshi; Casanova Mohr, Raimon; Casse, Gianluigi; Cassina, Lorenzo; Castillo Garcia, Lucia; Cattaneo, Marco; Cauet, Christophe; Cavallero, Giovanni; Cenci, Riccardo; Charles, Matthew; Charpentier, Philippe; Chefdeville, Maximilien; Chen, Shanzhen; Cheung, Shu-Faye; Chiapolini, Nicola; Chrzaszcz, Marcin; Cid Vidal, Xabier; Ciezarek, Gregory; Clarke, Peter; Clemencic, Marco; Cliff, Harry; Closier, Joel; Coco, Victor; Cogan, Julien; Cogneras, Eric; Cogoni, Violetta; Cojocariu, Lucian; Collazuol, Gianmaria; Collins, Paula; Comerma-Montells, Albert; Contu, Andrea; Cook, Andrew; Coombes, Matthew; Coquereau, Samuel; Corti, Gloria; Corvo, Marco; Couturier, Benjamin; Cowan, Greig; Craik, Daniel Charles; Crocombe, Andrew; Cruz Torres, Melissa Maria; Cunliffe, Samuel; Currie, Robert; D'Ambrosio, Carmelo; Dalseno, Jeremy; David, Pieter; Davis, Adam; De Bruyn, Kristof; De Capua, Stefano; De Cian, Michel; De Miranda, Jussara; De Paula, Leandro; De Silva, Weeraddana; De Simone, Patrizia; Dean, Cameron Thomas; Decamp, Daniel; Deckenhoff, Mirko; Del Buono, Luigi; Déléage, Nicolas; Derkach, Denis; Deschamps, Olivier; Dettori, Francesco; Dey, Biplab; Di Canto, Angelo; Di Ruscio, Francesco; Dijkstra, Hans; Donleavy, Stephanie; Dordei, Francesca; Dorigo, Mirco; Dosil Suárez, Alvaro; Dossett, David; Dovbnya, Anatoliy; Dreimanis, Karlis; Dufour, Laurent; Dujany, Giulio; Dupertuis, Frederic; Durante, Paolo; Dzhelyadin, Rustem; Dziurda, Agnieszka; Dzyuba, Alexey; Easo, Sajan; Egede, Ulrik; Egorychev, Victor; Eidelman, Semen; Eisenhardt, Stephan; Eitschberger, Ulrich; Ekelhof, Robert; Eklund, Lars; El Rifai, Ibrahim; Elsasser, Christian; Ely, Scott; Esen, Sevda; Evans, Hannah Mary; Evans, Timothy; Falabella, Antonio; Färber, Christian; Farinelli, Chiara; Farley, Nathanael; Farry, Stephen; Fay, Robert; Ferguson, Dianne; Fernandez Albor, Victor; Ferrari, Fabio; Ferreira Rodrigues, Fernando; Ferro-Luzzi, Massimiliano; Filippov, Sergey; Fiore, Marco; Fiorini, Massimiliano; Firlej, Miroslaw; Fitzpatrick, Conor; Fiutowski, Tomasz; Fohl, Klaus; Fol, Philip; Fontana, Marianna; Fontanelli, Flavio; Forty, Roger; Francisco, Oscar; Frank, Markus; Frei, Christoph; Frosini, Maddalena; Fu, Jinlin; Furfaro, Emiliano; Gallas Torreira, Abraham; Galli, Domenico; Gallorini, Stefano; Gambetta, Silvia; Gandelman, Miriam; Gandini, Paolo; Gao, Yuanning; García Pardiñas, Julián; Garofoli, Justin; Garra Tico, Jordi; Garrido, Lluis; Gascon, David; Gaspar, Clara; Gastaldi, Ugo; Gauld, Rhorry; Gavardi, Laura; Gazzoni, Giulio; Geraci, Angelo; Gerick, David; Gersabeck, Evelina; Gersabeck, Marco; Gershon, Timothy; Ghez, Philippe; Gianelle, Alessio; Gianì, Sebastiana; Gibson, Valerie; Girard, Olivier Göran; Giubega, Lavinia-Helena; Gligorov, V.V.; Göbel, Carla; Golubkov, Dmitry; Golutvin, Andrey; Gomes, Alvaro; Gotti, Claudio; Grabalosa Gándara, Marc; Graciani Diaz, Ricardo; Granado Cardoso, Luis Alberto; Graugés, Eugeni; Graverini, Elena; Graziani, Giacomo; Grecu, Alexandru; Greening, Edward; Gregson, Sam; Griffith, Peter; Grillo, Lucia; Grünberg, Oliver; Gui, Bin; Gushchin, Evgeny; Guz, Yury; Gys, Thierry; Hadjivasiliou, Christos; Haefeli, Guido; Haen, Christophe; Haines, Susan; Hall, Samuel; Hamilton, Brian; Hampson, Thomas; Han, Xiaoxue; Hansmann-Menzemer, Stephanie; Harnew, Neville; Harnew, Samuel; Harrison, Jonathan; He, Jibo; Head, Timothy; Heijne, Veerle; Hennessy, Karol; Henrard, Pierre; Henry, Louis; Hernando Morata, Jose Angel; van Herwijnen, Eric; Heß, Miriam; Hicheur, Adlène; Hill, Donal; Hoballah, Mostafa; Hombach, Christoph; Hulsbergen, Wouter; Humair, Thibaud; Hussain, Nazim; Hutchcroft, David; Hynds, Daniel; Idzik, Marek; Ilten, Philip; Jacobsson, Richard; Jaeger, Andreas; Jalocha, Pawel; Jans, Eddy; Jawahery, Abolhassan; Jing, Fanfan; John, Malcolm; Johnson, Daniel; Jones, Christopher; Joram, Christian; Jost, Beat; Jurik, Nathan; Kandybei, Sergii; Kanso, Walaa; Karacson, Matthias; Karbach, Moritz; Karodia, Sarah; Kelsey, Matthew; Kenyon, Ian; Kenzie, Matthew; Ketel, Tjeerd; Khanji, Basem; Khurewathanakul, Chitsanu; Klaver, Suzanne; Klimaszewski, Konrad; Kochebina, Olga; Kolpin, Michael; Komarov, Ilya; Koopman, Rose; Koppenburg, Patrick; Korolev, Mikhail; Kravchuk, Leonid; Kreplin, Katharina; Kreps, Michal; Krocker, Georg; Krokovny, Pavel; Kruse, Florian; Kucewicz, Wojciech; Kucharczyk, Marcin; Kudryavtsev, Vasily; Kuonen, Axel Kevin; Kurek, Krzysztof; Kvaratskheliya, Tengiz; La Thi, Viet Nga; Lacarrere, Daniel; Lafferty, George; Lai, Adriano; Lambert, Dean; Lambert, Robert W; Lanfranchi, Gaia; Langenbruch, Christoph; Langhans, Benedikt; Latham, Thomas; Lazzeroni, Cristina; Le Gac, Renaud; van Leerdam, Jeroen; Lees, Jean-Pierre; Lefèvre, Regis; Leflat, Alexander; Lefrançois, Jacques; Leroy, Olivier; Lesiak, Tadeusz; Leverington, Blake; Li, Yiming; Likhomanenko, Tatiana; Liles, Myfanwy; Lindner, Rolf; Linn, Christian; Lionetto, Federica; Liu, Bo; Liu, Xuesong; Lohn, Stefan; Longstaff, Iain; Lopes, Jose; Lowdon, Peter; Lucchesi, Donatella; Lucio Martinez, Miriam; Luo, Haofei; Lupato, Anna; Luppi, Eleonora; Lupton, Oliver; Machefert, Frederic; Maciuc, Florin; Maev, Oleg; Maguire, Kevin; Malde, Sneha; Malinin, Alexander; Manca, Giulia; Mancinelli, Giampiero; Manning, Peter Michael; Mapelli, Alessandro; Maratas, Jan; Marchand, Jean François; Marconi, Umberto; Marin Benito, Carla; Marino, Pietro; Märki, Raphael; Marks, Jörg; Martellotti, Giuseppe; Martinelli, Maurizio; Martinez Santos, Diego; Martinez Vidal, Fernando; Martins Tostes, Danielle; Massafferri, André; Matev, Rosen; Mathad, Abhijit; Mathe, Zoltan; Matteuzzi, Clara; Matthieu, Kecke; Mauri, Andrea; Maurin, Brice; Mazurov, Alexander; McCann, Michael; McCarthy, James; McNab, Andrew; McNulty, Ronan; Meadows, Brian; Meier, Frank; Meissner, Marco; Merk, Marcel; Milanes, Diego Alejandro; Minard, Marie-Noelle; Mitzel, Dominik Stefan; Molina Rodriguez, Josue; Monteil, Stephane; Morandin, Mauro; Morawski, Piotr; Mordà, Alessandro; Morello, Michael Joseph; Moron, Jakub; Morris, Adam Benjamin; Mountain, Raymond; Muheim, Franz; Müller, Janine; Müller, Katharina; Müller, Vanessa; Mussini, Manuel; Muster, Bastien; Naik, Paras; Nakada, Tatsuya; Nandakumar, Raja; Nasteva, Irina; Needham, Matthew; Neri, Nicola; Neubert, Sebastian; Neufeld, Niko; Neuner, Max; Nguyen, Anh Duc; Nguyen, Thi-Dung; Nguyen-Mau, Chung; Niess, Valentin; Niet, Ramon; Nikitin, Nikolay; Nikodem, Thomas; Ninci, Daniele; Novoselov, Alexey; O'Hanlon, Daniel Patrick; Oblakowska-Mucha, Agnieszka; Obraztsov, Vladimir; Ogilvy, Stephen; Okhrimenko, Oleksandr; Oldeman, Rudolf; Onderwater, Gerco; Osorio Rodrigues, Bruno; Otalora Goicochea, Juan Martin; Otto, Adam; Owen, Patrick; Oyanguren, Maria Aranzazu; Palano, Antimo; Palombo, Fernando; Palutan, Matteo; Panman, Jacob; Papanestis, Antonios; Pappagallo, Marco; Pappalardo, Luciano; Parkes, Christopher; Passaleva, Giovanni; Patel, Girish; Patel, Mitesh; Patrignani, Claudia; Pearce, Alex; Pellegrino, Antonio; Penso, Gianni; Pepe Altarelli, Monica; Perazzini, Stefano; Perret, Pascal; Pescatore, Luca; Petridis, Konstantinos; Petrolini, Alessandro; Petruzzo, Marco; Picatoste Olloqui, Eduardo; Pietrzyk, Boleslaw; Pilař, Tomas; Pinci, Davide; Pistone, Alessandro; Piucci, Alessio; Playfer, Stephen; Plo Casasus, Maximo; Poikela, Tuomas; Polci, Francesco; Poluektov, Anton; Polyakov, Ivan; Polycarpo, Erica; Popov, Alexander; Popov, Dmitry; Popovici, Bogdan; Potterat, Cédric; Price, Eugenia; Price, Joseph David; Prisciandaro, Jessica; Pritchard, Adrian; Prouve, Claire; Pugatch, Valery; Puig Navarro, Albert; Punzi, Giovanni; Qian, Wenbin; Quagliani, Renato; Rachwal, Bartolomiej; Rademacker, Jonas; Rakotomiaramanana, Barinjaka; Rama, Matteo; Rangel, Murilo; Raniuk, Iurii; Rauschmayr, Nathalie; Raven, Gerhard; Redi, Federico; Reichert, Stefanie; Reid, Matthew; dos Reis, Alberto; Ricciardi, Stefania; Richards, Sophie; Rihl, Mariana; Rinnert, Kurt; Rives Molina, Vincente; Robbe, Patrick; Rodrigues, Ana Barbara; Rodrigues, Eduardo; Rodriguez Lopez, Jairo Alexis; Rodriguez Perez, Pablo; Roiser, Stefan; Romanovsky, Vladimir; Romero Vidal, Antonio; Rotondo, Marcello; Rouvinet, Julien; Ruf, Thomas; Ruiz, Hugo; Ruiz Valls, Pablo; Saborido Silva, Juan Jose; Sagidova, Naylya; Sail, Paul; Saitta, Biagio; Salustino Guimaraes, Valdir; Sanchez Mayordomo, Carlos; Sanmartin Sedes, Brais; Santacesaria, Roberta; Santamarina Rios, Cibran; Santimaria, Marco; Santovetti, Emanuele; Sarti, Alessio; Satriano, Celestina; Satta, Alessia; Saunders, Daniel Martin; Savrina, Darya; Schiller, Manuel; Schindler, Heinrich; Schlupp, Maximilian; Schmelling, Michael; Schmelzer, Timon; Schmidt, Burkhard; Schneider, Olivier; Schopper, Andreas; Schubiger, Maxime; Schune, Marie Helene; Schwemmer, Rainer; Sciascia, Barbara; Sciubba, Adalberto; Semennikov, Alexander; Sepp, Indrek; Serra, Nicola; Serrano, Justine; Sestini, Lorenzo; Seyfert, Paul; Shapkin, Mikhail; Shapoval, Illya; Shcheglov, Yury; Shears, Tara; Shekhtman, Lev; Shevchenko, Vladimir; Shires, Alexander; Silva Coutinho, Rafael; Simi, Gabriele; Sirendi, Marek; Skidmore, Nicola; Skillicorn, Ian; Skwarnicki, Tomasz; Smith, Edmund; Smith, Eluned; Smith, Jackson; Smith, Mark; Snoek, Hella; Sokoloff, Michael; Soler, Paul; Soomro, Fatima; Souza, Daniel; Souza De Paula, Bruno; Spaan, Bernhard; Spradlin, Patrick; Sridharan, Srikanth; Stagni, Federico; Stahl, Marian; Stahl, Sascha; Steinkamp, Olaf; Stenyakin, Oleg; Sterpka, Christopher Francis; Stevenson, Scott; Stoica, Sabin; Stone, Sheldon; Storaci, Barbara; Stracka, Simone; Straticiuc, Mihai; Straumann, Ulrich; Sun, Liang; Sutcliffe, William; Swientek, Krzysztof; Swientek, Stefan; Syropoulos, Vasileios; Szczekowski, Marek; Szczypka, Paul; Szumlak, Tomasz; T'Jampens, Stephane; Tekampe, Tobias; Teklishyn, Maksym; Tellarini, Giulia; Teubert, Frederic; Thomas, Christopher; Thomas, Eric; van Tilburg, Jeroen; Tisserand, Vincent; Tobin, Mark; Todd, Jacob; Tolk, Siim; Tomassetti, Luca; Tonelli, Diego; Topp-Joergensen, Stig; Torr, Nicholas; Tournefier, Edwige; Tourneur, Stephane; Trabelsi, Karim; Tran, Minh Tâm; Tresch, Marco; Trisovic, Ana; Tsaregorodtsev, Andrei; Tsopelas, Panagiotis; Tuning, Niels; Ukleja, Artur; Ustyuzhanin, Andrey; Uwer, Ulrich; Vacca, Claudia; Vagnoni, Vincenzo; Valenti, Giovanni; Vallier, Alexis; Vazquez Gomez, Ricardo; Vazquez Regueiro, Pablo; Vázquez Sierra, Carlos; Vecchi, Stefania; Velthuis, Jaap; Veltri, Michele; Veneziano, Giovanni; Vesterinen, Mika; Viaud, Benoit; Vieira, Daniel; Vieites Diaz, Maria; Vilasis-Cardona, Xavier; Vollhardt, Achim; Volyanskyy, Dmytro; Voong, David; Vorobyev, Alexey; Vorobyev, Vitaly; Voß, Christian; de Vries, Jacco; Waldi, Roland; Wallace, Charlotte; Wallace, Ronan; Walsh, John; Wandernoth, Sebastian; Wang, Jianchun; Ward, David; Watson, Nigel; Websdale, David; Weiden, Andreas; Whitehead, Mark; Wiedner, Dirk; Wilkinson, Guy; Wilkinson, Michael; Williams, Mark Richard James; Williams, Matthew; Williams, Mike; Wilson, Fergus; Wimberley, Jack; Wishahi, Julian; Wislicki, Wojciech; Witek, Mariusz; Wormser, Guy; Wotton, Stephen; Wright, Simon; Wyllie, Kenneth; Xie, Yuehong; Xu, Zhirui; Yang, Zhenwei; Yuan, Xuhao; Yushchenko, Oleg; Zangoli, Maria; Zavertyaev, Mikhail; Zhang, Liming; Zhang, Yanxi; Zhelezov, Alexey; Zhokhov, Anatoly; Zhong, Liang

    2015-01-01

    Identification of jets originating from beauty and charm quarks is important for measuring Standard Model processes and for searching for new physics. The performance of algorithms developed to select $b$- and $c$-quark jets is measured using data recorded by LHCb from proton-proton collisions at $\\sqrt{s}=7$ TeV in 2011 and at $\\sqrt{s}=8$ TeV in 2012. The efficiency for identifying a $b(c)$ jet is about 65%(25%) with a probability for misidentifying a light-parton jet of 0.3% for jets with transverse momentum $p_{\\rm T} > 20$ GeV and pseudorapidity $2.2 < \\eta < 4.2$. The dependence of the performance on the $p_{\\rm T}$ and $\\eta$ of the jet is also measured.

  10. Beauty and charm production in DIS using semileptonic electron decays

    Energy Technology Data Exchange (ETDEWEB)

    Shehzadi, Ramoona [Physikalisches Institut, University of Bonn (Germany)

    2009-07-01

    Heavy flavor production in ep collisions using semileptonic decays into electrons and muons is a central topic of research at HERA. In one of the analyses recently published by the ZEUS collaboration for beauty production in the photoproduction, a likelihood method was used for the signal extraction using semileptonic electron decays. This analysis was based on HERA I data. A similar kind of approach is intended to be used for analysis of HERA II data, not only in the photoproduction but also in the DIS regime. The increased statistics and possibility of measuring the life time information because of the presence of the Micro Vertex Detector (MVD) in HERA II data will also help to increase the precision of the measurement. This talk focuses on the ongoing DIS analysis. Results based on a subsample of HERA II data for DIS selection, identification of semileptonic electron candidates and extraction of signal are presented.

  11. R&D for Collider Beauty Physics at the LHC

    CERN Multimedia

    2002-01-01

    We propose an R&D program for the development of a Beauty trigger and innovative elements of the associated spectrometer. The program builds on the success of the recent S$\\bar{p}$pS collider run of the P238 Collaboration, in which clean signals from beam-beam interactions were observed in a large silicon strip microvertex detector running 1.5~mm from the circulating beams. A continuing successful R&D program of the type proposed could ultimately lead to a collider experiment at the LHC to study CP-violation and rare B decays. \\\\ \\\\ We request a fixed target run during late 1992 in order to demonstrate the effectiveness of a heavy flavour trigger which uses real time digital calculations on silicon strip data, implemented with a data driven processor.

  12. Stolen beauty: gender, aesthetics and embodiment in Brazilian drama

    Directory of Open Access Journals (Sweden)

    Heloisa Pontes

    2008-01-01

    Full Text Available Drawing from a broader research on gender inflections in the Brazilian intellectual field and in Brazilian drama, between 1940 and 1968, the article discusses the relations between aesthetics and gender, and their implications on the careers of actresses Cacilda Becker, Maria Della Costa, Tônia Carrero and Cleyde Yáconis. According to testimony of those who saw her perform on stage, Cacilda was never hampered by her less favorable physical attributes. The hypothesis is that this is due to the cunning tricks of the conventions of dramatic arts that allow the dodging of social, gender and physical constraints. Widely evoked by the media to portrait, underline or diminish women under its focus, beauty rarely features as a relevant dimension in the analysis of female trajectories. Hence the interest in discussing the subject through its refraction on the process of social construction of artistic careers.

  13. CP violation in multibody decays of beauty baryons

    Science.gov (United States)

    Durieux, Gauthier

    2016-10-01

    Beauty baryons are being observed in large numbers in the LHCb detector. The rich kinematic distributions of their multibody decays are therefore becoming accessible and provide us with new opportunities to search for CP violation. We analyse the angular distributions of some three- and four-body decays of spin-1/2 baryons using the Jacob-Wick helicity formalism. The asymmetries that provide access to small differences of CP-odd phases between decay amplitudes of identical CP-even phases are notably discussed. The understanding gained on processes featuring specific resonant intermediate states allows us to establish which asymmetries are relevant for what purpose. It is for instance shown that some CP-odd angular asymmetries measured by the LHCb collaboration in the Λ b → Λ φ → p π K + K - decay are expected to vanish identically.

  14. Beauty production in DIS using semileptonic electron decays at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Shehzadi, Ramoona [Physikalisches Institut, University Bonn (Germany)

    2010-07-01

    Heavy flavour production in ep collisions using semileptonic decays into electrons and muons is a central topic of research at HERA. A likelihood method using semileptonic electron decays for beauty production in photoproduction was used by the ZEUS collaboration for the HERA I data and is now being extended to the HERA II data. A similar kind of approach has been adopted to analyse DIS events. The increased statistics and possibility of using the lifetime information, due to the presence of the Micro-Vertex Detector (MVD) in the HERA II data, improves the precision of the measurement. This talk focuses on the ongoing DIS analysis. Results based on the HERA II data set for DIS selection, identification of semileptonic electron candidates and extraction of signal are presented.

  15. Flavour physics and the Large Hadron Collider beauty experiment.

    Science.gov (United States)

    Gibson, Valerie

    2012-02-28

    An exciting new era in flavour physics has just begun with the start of the Large Hadron Collider (LHC). The LHCb (where b stands for beauty) experiment, designed specifically to search for new phenomena in quantum loop processes and to provide a deeper understanding of matter-antimatter asymmetries at the most fundamental level, is producing many new and exciting results. It gives me great pleasure to describe a selected few of the results here-in particular, the search for rare B(0)(s)-->μ+ μ- decays and the measurement of the B(0)(s) charge-conjugation parity-violating phase, both of which offer high potential for the discovery of new physics at and beyond the LHC energy frontier in the very near future.

  16. BEAUTY, HEALTH AND WELL-BEING WITH COSMETOTEXTILES

    Directory of Open Access Journals (Sweden)

    CRETU Viorica

    2014-05-01

    Full Text Available The concept of cosmetotextiles, as another aspect of new beauty and health marques a growing success. This hybrid fabric, is definite as a textile article that contains a substance that is release sustainable on the human body skin pointed to perfume, change of appearance, maintenance in good condition, protection, or correction of body odors. Cosmetotextiles are created by microencapsulating different substances for body care or health, that are gradually transfer to the skin, by movement, pressure or the effect of the skin’s natural warmth and enzymes. The paper presents some elements regarding to the microencapsulating process (the major components of them general structure, the major advantages compare to usual presentation of cosmetic substances, some of the used active ingredients and them specific cosmetic and health benefits and the new generation of cosmetotextiles that bring together the latest innovations in fiber and textile structures and products. So, one of the manufacturing processes of a cosmetotextile is based on functionalisation of fibers by fixing microcapsules in them structure, resulting fibers as Novorel, Tencel C, Nilit Breeze, Emana, or by the functionalisation of fabrics, so of products made by these fabrics, where microcapsules are fixed on the external surface of the fabric, resulting in revolutionary “fabrics’ treatments” for beauty, health-care and well-being. Among these cosmeto fabrics and products are Sensitive Ultra Light Firming fabric, Sensitive Fabric Body ware, textile fabrics with the revolutionary Quiospheres technology, Doubleskin and different cosmeto-knitted products including specific placed areas with micro encapsulated ingredients, depending on them destinations (slimming, anti-cellulite treatment, corrective effect

  17. Recurrent encephalopathy? No I'm a sleeping beauty!

    Science.gov (United States)

    Iqbal, Mehtab; Prasad, Manish; Ritey, Christopher

    2014-01-01

    To describe the clinical presentation of 'Kleine-Levin (sleeping beauty) syndrome' in a child, who presented with recurrent episodes consistent with encephalopathy, associated with excessive sleepiness, cognitive and behavioural disturbance and hyper sexuality. 14 years old boy presented acutely with excessive tiredness, sleeping excessively, abnormal behaviour and hypersexuality following a viral throat infection. On examination he was sleepy but easily arousable. His GCS (15/15) and rest of the neurological examination including fundoscopy and other systemic examination was completely unremarkable. All his initial investigations including electrolytes, LFTs, CSF, virology screen and MRI brain scan were normal. Detailed autoimmune screening was also negative. EEG showed non-specific diffuse slowing consistent with encephalopathy. His excessive sleepiness gradually improved together with his altered behaviour in about two weeks after presentation. Hyper sexuality became more overt during this phase. All these symptoms completely disappeared three weeks after his presentation and he attended school as before. He was readmitted six weeks later with exactly similar presentation and again only positive result being diffuse non-specific slowing of EEG. His recovery was also similar and he was completely back to his normal self in three weeks time. His recurrent symptoms were consistent with 'Kleine-Levin syndrome (KLS)' or 'sleeping beauty syndrome'. KLS is a rare disorder which mainly affects adolescent males. Common symptoms include hypersomnia (100%), cognitive changes (96%), eating disturbances (80%), hypersexuality, compulsions, and depressed mood. The syndrome usually lasts for 8 years, with on an average seven episode of 10 days each recurring every 3.5 months. It is most frequently precipitated by infections and somnolence decreases using stimulants in nearly 40% of cases.

  18. Recurrent encephalopathy? No I′m a sleeping beauty!

    Directory of Open Access Journals (Sweden)

    Mehtab Iqbal

    2014-01-01

    Full Text Available To describe the clinical presentation of ′Kleine-Levin (sleeping beauty syndrome′ in a child, who presented with recurrent episodes consistent with encephalopathy, associated with excessive sleepiness, cognitive and behavioural disturbance and hyper sexuality. 14 years old boy presented acutely with excessive tiredness, sleeping excessively, abnormal behaviour and hypersexuality following a viral throat infection. On examination he was sleepy but easily arousable. His GCS (15/15 and rest of the neurological examination including fundoscopy and other systemic examination was completely unremarkable. All his initial investigations including electrolytes, LFTs, CSF, virology screen and MRI brain scan were normal. Detailed autoimmune screening was also negative. EEG showed non-specific diffuse slowing consistent with encephalopathy. His excessive sleepiness gradually improved together with his altered behaviour in about two weeks after presentation. Hyper sexuality became more overt during this phase. All these symptoms completely disappeared three weeks after his presentation and he attended school as before. He was readmitted six weeks later with exactly similar presentation and again only positive result being diffuse non-specific slowing of EEG. His recovery was also similar and he was completely back to his normal self in three weeks time. His recurrent symptoms were consistent with ′Kleine-Levin syndrome (KLS′ or ′sleeping beauty syndrome′. KLS is a rare disorder which mainly affects adolescent males. Common symptoms include hypersomnia (100%, cognitive changes (96%, eating disturbances (80%, hypersexuality, compulsions, and depressed mood. The syndrome usually lasts for 8 years, with on an average seven episode of 10 days each recurring every 3.5 months. It is most frequently precipitated by infections and somnolence decreases using stimulants in nearly 40% of cases.

  19. Recurrent encephalopathy? No I’m a sleeping beauty!

    Science.gov (United States)

    Iqbal, Mehtab; Prasad, Manish; Ritey, Christopher

    2014-01-01

    To describe the clinical presentation of ‘Kleine-Levin (sleeping beauty) syndrome’ in a child, who presented with recurrent episodes consistent with encephalopathy, associated with excessive sleepiness, cognitive and behavioural disturbance and hyper sexuality. 14 years old boy presented acutely with excessive tiredness, sleeping excessively, abnormal behaviour and hypersexuality following a viral throat infection. On examination he was sleepy but easily arousable. His GCS (15/15) and rest of the neurological examination including fundoscopy and other systemic examination was completely unremarkable. All his initial investigations including electrolytes, LFTs, CSF, virology screen and MRI brain scan were normal. Detailed autoimmune screening was also negative. EEG showed non-specific diffuse slowing consistent with encephalopathy. His excessive sleepiness gradually improved together with his altered behaviour in about two weeks after presentation. Hyper sexuality became more overt during this phase. All these symptoms completely disappeared three weeks after his presentation and he attended school as before. He was readmitted six weeks later with exactly similar presentation and again only positive result being diffuse non-specific slowing of EEG. His recovery was also similar and he was completely back to his normal self in three weeks time. His recurrent symptoms were consistent with ‘Kleine-Levin syndrome (KLS)’ or ‘sleeping beauty syndrome’. KLS is a rare disorder which mainly affects adolescent males. Common symptoms include hypersomnia (100%), cognitive changes (96%), eating disturbances (80%), hypersexuality, compulsions, and depressed mood. The syndrome usually lasts for 8 years, with on an average seven episode of 10 days each recurring every 3.5 months. It is most frequently precipitated by infections and somnolence decreases using stimulants in nearly 40% of cases. PMID:24891916

  20. Measurement of open beauty production at HERA in the D* muon final state

    CERN Document Server

    Chekanov, S; Magill, S; Miglioranzi, S; Musgrave, B; Nicholass, D; Repond, J; Yoshida, R; Mattingly, M C K; Pavel, N; Yagues-Molina, A G; Antonelli, S; Antonioli, P; Bari, G; Basile, M; Bellagamba, L; Bindi, M; Boscherini, D; Bruni, A; Bruni, G; Cifarelli, L; Cindolo, F; Contin, A; Corradi, M; De Pasquale, S; Iacobucci, G; Margotti, A; Nania, R; Polini, A; Rinaldi, L; Sartorelli, G; Zichichi, A; Aghuzumtsyan, G; Bartsch, D; Brock, I; Goers, S; Hartmann, H; Hilger, E; Jakob, H P; Jüngst, M; Kind, O M; Paul, E; Rautenberg, J; Renner, R; Samson, U; Schonberg, V; Wang, M; Wlasenko, M; Brook, N H; Heath, G P; Morris, J D; Namsoo, T; Capua, M; Fazio, S; Mastroberardino, A; Schioppa, M; Susinno, G; Tassi, E; Kim, J Y; Ma, K J; Ibrahim, Z A; Kamaluddin, B; Wan-Abdullah, W A T; Ning, Y; Ren, Z; Sciulli, F; Chwastowski, J; Eskreys, A; Figiel, J; Galas, A; Gil, M; Olkiewicz, K; Stopa, P; Zaw, I; Adamczyk, L; Bold, T; Grabowska-Bold, I; Kisielewska, D; Lukasik, J; Przybycien, M B; Suszycki, L; Kotanski, A; Slominski, W; Adler, V; Behrens, U; Bloch, I; Bonato, A; Borras, K; Coppola, N; Fourletova, J; Geiser, A; Gladkov, D; Göttlicher, P; Gregor, I; Haas, T; Hain, W; Horn, C; Kahle, B; Kötz, U; Kowalski, H; Lobodzinska, E; Löhr, B; Mankel, R; Melzer-Pellmann, I A; Montanari, A; Notz, D; Nuncio-Quiroz, A E; Santamarta, R; Schneekloth, U; Spiridonov, A A; Stadie, H; Stösslein, U; Szuba, D; Szuba, J; Theedt, T; Wolf, G; Wrona, K; Youngman, C; Zeuner, W; Schlenstedt, S; Barbagli, G; Gallo, E; Pelfer, P G; Bamberger, A; Dobur, D; Karstens, F; Vlasov, N N; Bussey, P J; Doyle, A T; Dunne, W; Ferrando, J; Saxon, D H; Skillicorn, I O; Gialas, I; Gosau, T; Holm, U; Klanner, Robert; Lohrmann, E; Salehi, H; Schleper, P; Schörner-Sadenius, T; Sztuk, J; Wichmann, K; Wick, K; Foudas, C; Fry, C; Long, K R; Tapper, A D; Kataoka, M; Matsumoto, T; Nagano, K; Tokushuku, K; Yamada, S; Yamazaki, Y; Barakbaev, A N; Boos, E G; Dossanov, A; Pokrovskiy, N S; Zhautykov, B O; Son, D; De Favereau, J; Piotrzkowski, K; Barreiro, F; Glasman, C; Jiménez, M; Labarga, L; Del Peso, J; Ron, E; Terron, J; Zambrana, M; Corriveau, F; Liu, C; Walsh, R; Zhou, C; Tsurugai, T; Antonov, A; Dolgoshein, B A; Rubinsky, I; Sosnovtsev, V V; Stifutkin, A; Suchkov, S; Dementiev, R K; Ermolov, P F; Gladilin, L K; Katkov, I I; Khein, L A; Korzhavina, I A; Kuzmin, V A; Levchenko, B B; Lukina, O Yu; Proskuryakov, A S; Shcheglova, L M; Zotkin, D S; Zotkin, S A; Abt, I; Büttner, C; Caldwell, A; Kollar, D; Schmidke, W B; Sutiak, J; Grigorescu, G; Keramidas, A; Koffeman, E; Kooijman, P; Pellegrino, A; Tiecke, H G; Vázquez, M; Wiggers, L; Brümmer, N; Bylsma, B; Durkin, L S; Lee, A; Ling, T Y; Allfrey, P D; Bell, M A; Cooper-Sarkar, A M; Cottrell, A; Devenish, R C E; Foster, B; Korcsak-Gorzo, K; Patel, S; Roberfroid, V; Robertson, A; Straub, P B; Uribe, C; Estrada, J; Walczak, R; Bellan, P M; Bertolin, A; Brugnera, R; Carlin, R; Ciesielski, R; Dal Corso, F; Dusini, S; Garfagnini, A; Limentani, S; Longhin, A; Stanco, L; Turcato, M; Oh, B Y; Raval, A; Ukleja, J; Whitmore, J J; Iga, Y; D'Agostini, G; Marini, G; Nigro, A; Cole, J E; Hart, J C; Abramowicz, H; Gabareen, A; Ingbir, R; Kananov, S; Levy, A; Kuze, M; Hori, R; Kagawa, S; Okazaki, N; Shimizu, S; Tawara, T; Hamatsu, R; Kaji, H; Kitamura, S; Ota, O; Ri, Y D; Ferrero, M I; Monaco, V; Sacchi, R; Solano, A; Arneodo, M; Ruspa, M; Fourletov, S; Martin, J F; Boutle, S K; Butterworth, J M; Gwenlan, C; Jones, T W; Loizides, J H; Sutton, M R; Targett-Adams, C; Wing, M; Brzozowska, B; Ciborowski, J; Grzelak, G; Kulinski, P; Luzniak, P; Malka, J; Nowak, R J; Pawlak, J M; Tymieniecka, T; Ukleja, A; Adamus, M; Plucinsky, P P; Eisenberg, Y; Giller, I; Hochman, D; Karshon, U; Rosin, M; Brownson, E; Danielson, T; Everett, A; Kcira, D; Reeder, D D; Ryan, P; Savin, A A; Smith, W H; Wolfe, H; Bhadra, S; Catterall, C D; Cui, Y; Hartner, G; Menary, S; Noor, U; Soares, M; Standage, J; Whyte, J

    2006-01-01

    The production of beauty quarks with a D*+- and a muon in the final state has been measured with the ZEUS detector at HERA using an integrated luminosity of 114 pb-1. Low transverse-momentum thresholds for the muon and D* meson allow a measurement of beauty production closer to the production threshold than previous measurements. The beauty signal was extracted using the charge correlations and angular distributions of the muon with respect to the D* meson. Cross sections for photoproduction and deep inelastic scattering are somewhat higher than, but compatible with, next-to-leading-order QCD predictions, and compatible with other measurements.

  1. Feasibility of Utilizing Ethnic Beauty Salons for Cervical Cancer Screening Education.

    Science.gov (United States)

    Lee, Jongwon; Carvallo, Mauricio; Lee, Eunice

    2015-11-01

    The purpose of this study was to assess the feasibility of using ethnic beauty salons to reach out to Vietnamese and Korean American women for cervical cancer screening education. Participants (N = 62) were conveniently recruited from ethnic beauty salons located in Albuquerque, New Mexico. Two feasibility questionnaires were separately administered to cosmetologists and their customers. Findings support the view that ethnic beauty salons can be used as a gateway to reach out to these populations, and cosmetologists have the potential to operate as community lay health workers to deliver cervical cancer screening education aimed at reducing disparities in cervical cancer and screening to their ethnic customers.

  2. Measurement of Charm and Beauty Photoproduction at HERA using D* mu Correlations

    CERN Document Server

    Aktas, A; Anthonis, T; Asmone, A; Babaev, A; Backovic, S; Bähr, J; Baranov, P; Barrelet, E; Bartel, Wulfrin; Baumgartner, S; Becker, J; Beckingham, M; Behnke, O; Behrendt, O; Belousov, A; Berger, C; Berger, N; Berndt, T; Bizot, J C; Böhme, J; Boenig, M O; Boudry, V; Bracinik, J; Brisson, V; Broker, H B; Brown, D P; Bruncko, Dusan; Büsser, F W; Bunyatyan, A; Buschhorn, G; Bystritskaya, L; Campbell, A J; Caron, S; Cassol-Brunner, F; Cerny, K; Chekelian, V; Contreras, J G; Coppens, Y R; Coughlan, J A; Cox, B E; Cozzika, G; Cvach, J; Dainton, J B; Dau, W D; Daum, K; Delcourt, B; Demirchyan, R; de Roeck, A; Desch, Klaus; De Wolf, E A; Diaconu, C; Dingfelder, J; Dodonov, V; Dubak, A; Duprel, C; Eckerlin, G; Efremenko, V; Egli, S; Eichler, R; Eisele, F; Ellerbrock, M; Elsen, E; Erdmann, W; Faulkner, P J W; Favart, L; Fedotov, A; Felst, R; Ferencei, J; Fleischer, M; Fleischmann, P; Fleming, Y H; Flucke, G; Flügge, G; Fomenko, A; Foresti, I; Formánek, J; Franke, G; Frising, G; Gabathuler, Erwin; Gabathuler, K; Garutti, E; Garvey, J; Gayler, J; Gerhards, R; Gerlich, C; Ghazaryan, S; Ginzburgskaya, S; Görlich, L; Gogitidze, N; Gorbounov, S; Grab, C; Grässler, Herbert; Greenshaw, T; Gregori, M; Grindhammer, G; Gwilliam, C; Haidt, D; Hajduk, L; Haller, J; Hansson, M; Heinzelmann, G; Henderson, R C W; Henschel, H; Henshaw, O; Herrera-Corral, G; Herynek, I; Heuer, R D; Hildebrandt, M; Hiller, K H; Hoting, P; Hoffmann, D; Horisberger, R P; Hovhannisyan, A; Ibbotson, M; Ismail, M; Jacquet, M; Janauschek, L; Janssen, X; Jemanov, V; Jönsson, L B; Johnson, D P; Jung, H; Kant, D; Kapichine, M; Karlsson, M; Katzy, J; Keller, N; Kenyon, I R; Kiesling, C; Klein, M; Kleinwort, C; Klimkovich, T; Kluge, T; Knies, G; Knutsson, A; Koblitz, B; Korbel, V; Kostka, P; Koutouev, R; Kropivnitskaya, A; Kroseberg, J; Krüger, K; Kuckens, J; Landon, M P J; Lange, W; Lastoviicka, T; Laycock, P; Lebedev, A; Leiner, B; Lemrani, R; Lendermann, V; Levonian, S; Lindfeld, L; Lipka, K; List, B; Lobodzinska, E; Loktionova, N; López-Fernandez, R; Lubimov, V; Lüders, H; Lüke, D; Lux, T; Lytkin, L; Makankine, A; Malden, N; Malinovskii, E I; Mangano, S; Marage, P; Marks, J; Marshall, R; Martisikova, M; Martyn, H U; Maxfield, S J; Meer, D; Mehta, A; Meier, K; Meyer, A B; Meyer, H; Meyer, J; Mikocki, S; Milcewicz-Mika, I; Milstead, D; Mohamed, A; Moreau, F; Morozov, A; Morris, J V; Mozer, M U; Müller, K; Murn, P; Nagovizin, V; Nankov, K; Naroska, Beate; Naumann, J; Naumann, T; Newman, P R; Niebuhr, C B; Nikiforov, A; Nikitin, D K; Nowak, G; Nozicka, M; Oganezov, R; Olivier, B; Olsson, J E; Ozerov, D; Paramonov, A A; Pascaud, C; Patel, G D; Peez, M; Pérez, E; Perieanu, A; Petrukhin, A; Pitzl, D; Placakyte, R; Pöschl, R; Portheault, B; Povh, B; Raicevic, N; Reimer, P; Reisert, B; Rimmer, A; Risler, C; Rizvi, E; Robmann, P; Roland, B; Roosen, R; Rostovtsev, A; Rurikova, Z; Rusakov, S V; Rybicki, K; Sankey, D P C; Sauvan, E; Schatzel, S; Scheins, J; Schilling, F P; Schleper, P; Schmidt, S; Schmitt, S; Schneider, M; Schoeffel, L; Schöning, A; Schröder, V; Schultz-Coulon, H C; Schwanenberger, C; Sedlak, K; Sefkow, F; Shevyakov, I; Shtarkov, L N; Sirois, Y; Sloan, T; Smirnov, P; Soloviev, Yu; South, D; Spaskov, V; Specka, A; Spitzer, H; Stamen, R; Stella, B; Stiewe, J; Strauch, I; Straumann, U; Tchoulakov, V; Thompson, G; Thompson, P D; Tomasz, F; Traynor, D; Truöl, P; Tsipolitis, G; Tsurin, I; Turnau, J; Tzamariudaki, E; Uraev, A; Urban, M; Usik, A; Utkin, D; Valkár, S; Valkárová, A; Vallée, C; Van Mechelen, P; Van Remortel, N; Vargas-Trevino, A; Vazdik, Ya A; Veelken, C; Vest, A; Vinokurova, S; Volchinski, V; Wacker, K; Wagner, J; Weber, G; Weber, R; Wegener, D; Werner, C; Werner, N; Wessels, M; Wessling, B; Winter, G G; Wissing, C; Woerling, E E; Wolf, R; Wünsch, E; Xella, S M; Yan, W; Yeganov, V; Zaicek, J; Zaleisak, J; Zhang, Z; Zhelezov, A; Zhokin, A; Zohrabyan, H G; Zomer, F

    2005-01-01

    A measurement of charm and beauty photoproduction at the electron proton collider HERA is presented based on the simultaneous detection of a D*^{\\pm} meson and a muon. The correlation between the D* meson and the muon serves to separate the charm and beauty contributions and the analysis provides comparable sensitivity to both. The total and differential experimental cross sections are compared to LO and NLO QCD calculations. The measured charm cross section is in good agreement with QCD predictions including higher order effects while the beauty cross section is higher.

  3. Servqual Method: Analisis Kualitas Pelayanan Beauty Advisor Sari Ayu Martha Tilaar

    Directory of Open Access Journals (Sweden)

    Ami Widyastuti

    2012-12-01

    Full Text Available Penelitian ini bertujuan untuk menganalisa kualitas pelayanan beauty advisor Sari Ayu Martha Tilaar guna meningkatkan kualitas pelayanan pada konsumen. Pengambilan data menggunakan skala kualitas pelayanan yang disusun berdasarkan metode Servqual dari (Parasuraman, dkk., 1988 pada 72 orang konsumen Sari Ayu Martha Tilaar. Sampel diambil dengan menggunakan teknik insidental random sampling. Analisis data menggunakan pengukuran gap 5 dari metode Servqual. Hasil penelitian menemukan ada kesenjangan pelayanan (service gap antara persepsi dan harapan konsumen sebesar -81.09 dimana nilai minus disini berarti, kinerja kerja beauty advisor Sari Ayu Martha Tilaar berada pada kategori rendah. Kesimpulannya, beauty advisor sebagai garda lini depan dalam pemasaran belum bekerja secara optimal.

  4. The culture of complexion: the impacts of society's role in shaping the definition of beauty.

    Science.gov (United States)

    Carlock, Sarah; Russell, Brian

    2015-05-01

    The definition of beauty has evolved as the trends valued by the top of society change. For centuries, fair skin was a requirement of the Western definition of beauty; however, a shift in the 1920s made tanned skin the new standard. In this article, smoking and tanning are presented as risky behaviors that are perpetuated through industry advertising and exploitation of the authority of health professionals. The article further explores the culture of complexion in Western society before and after the 1920s as well as the consequences of tanning and efforts to rewrite society's definition of beauty.

  5. The Beauty of Colors in Oscar Wilde's Words%The Beauty of Colors in Oscar Wilde's Words

    Institute of Scientific and Technical Information of China (English)

    刘天依

    2012-01-01

    As the leading figure of Aestheticism, Oscar Wilde is famous for his living style and his wonderful works. He wears bright clothes, speaks witty words, lives in his own way. Still, it's full of beauty in his works. What he has written, no matter "nightingale " or "rose", "Dorian Gray" or "Solome", all images shows gorgeous colors, making me feel that as if we were in the garden of words , Here the author wants to discuss the beauty of colors in Wilde's distinct words, to our vision and feeling, and also, the wonderful effects it has made.%作为唯美主义运动的代表人物,奥斯卡。王尔德不仅服装耀眼,谈吐机智,特立独行,而且他的文学作品也充满了无限的美感。他的文字,无论是“夜莺”还是“玫瑰”,无论是写“道林。格雷”还是“莎乐荚”,所有的意象都显示出色彩上的五彩缤纷,使我们犹如置身文字花园之感。在此我将讨论王尔德鲜明的文字给我们带来视觉和感觉上的美感,使用其所带来的艺术效果。

  6. The Realm of Fairy Story: J.R.R. Tolkien and Robin McKinley's "Beauty."

    Science.gov (United States)

    Woolsey, Daniel P.

    1991-01-01

    Discusses the development of a modern fairy tale with respect to J.R.R. Tolkien's mapping of its features, terrain, and emotional geography. Discusses Robin McKinley's "Beauty," an example of a modern fantasy. (PRA)

  7. Automated classification of female facial beauty by image analysis and supervised learning

    Science.gov (United States)

    Gunes, Hatice; Piccardi, Massimo; Jan, Tony

    2004-01-01

    The fact that perception of facial beauty may be a universal concept has long been debated amongst psychologists and anthropologists. In this paper, we performed experiments to evaluate the extent of beauty universality by asking a number of diverse human referees to grade a same collection of female facial images. Results obtained show that the different individuals gave similar votes, thus well supporting the concept of beauty universality. We then trained an automated classifier using the human votes as the ground truth and used it to classify an independent test set of facial images. The high accuracy achieved proves that this classifier can be used as a general, automated tool for objective classification of female facial beauty. Potential applications exist in the entertainment industry and plastic surgery.

  8. A Beautiful Life——Notes on Opening of Exhibition on History of CPAFFC

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    <正>The opening of the Exhibition on the History of the CPAFFC in the beautiful compound of the CPAFFC is like one of its evergreen trees,with blossoms and fruits pleasant to the eye and uplifting the hearts.

  9. Finding the Place of Everyday Beauty: Correspondence as a Method of Data Collection

    Directory of Open Access Journals (Sweden)

    Pauliina Rautio

    2009-06-01

    Full Text Available Researching aesthetic engaging with one's surroundings in everyday life led the author to use correspondence as a method of data collection. In this paper she presents her research design and discusses correspondence as an underused method. She introduces the concepts of invisibility, time, and tangibility in defining correspondence as a method. The topic of the correspondence in her research was beauty. In common use beautiful signals that which is desirable. As an evaluative and a future-oriented statement everyday beauty seems to have a place in steering our lives. The participants accounted as beautiful the different meaningful relations they had formed over time to their surroundings. These relations were in constant change as the participants themselves changed over time. The author argues that correspondence is a method that works well in cumulating data for research. It has also proven to be a rewarding method for the participants.

  10. Measurement of beauty production in deep inelastic scattering at HERA using decays into electrons

    CERN Document Server

    Abramowicz, H; Adamczyk, L; Adamus, M; Aggarwal, R; Antonelli, S; Antonioli, P; Antonov, A; Arneodo, M; Aushev, V; Aushev, Y; Bachynska, O; Bamberger, A; Barakbaev, A N; Barbagli, G; Bari, G; Barreiro, F; Bartosik, N; Bartsch, D; Basile, M; Behnke, O; Behr, J; Behrens, U; Bellagamba, L; Bertolin, A; Bhadra, S; Bindi, M; Blohm, C; Bokhonov, V; Bołd, T; Bolilyi, O; Boos, E G; Borras, K; Boscherini, D; Bot, D; Boutle, S K; Brock, I; Brownson, E; Brugnera, R; Brümmer, N; Bruni, A; Bruni, G; Brzozowska, B; Bussey, P J; Butterworth, J M; Bylsma, B; Caldwell, A; Capua, M; Carlin, R; Catterall, C D; Chekanov, S; Chwastowski, J; Ciborowski, J; Ciesielski, R; Cifarelli, L; Cindolo, F; Contin, A; Cooper-Sarkar, A M; Coppola, N; Corradi, M; Corriveau, F; Costa, M; D'Agostini, G; Corso, F Dal; del Peso, J; Dementiev, R K; De Pasquale, S; Derrick, M; Devenish, R C E; Dobur, D; Dolgoshein, B A; Dolinska, G; Doyle, A T; Drugakov, V; Durkin, L S; Dusini, S; Eisenberg, Y; Ermolov, P F; Eskreys, A; Fang, S; Fazio, S; Ferrando, J; Ferrero, M I; Figiel, J; Forrest, M; Foster, B; Fourletov, S; Gach, G; Galas, A; Gallo, E; Garfagnini, A; Geiser, A; Gialas, I; Gladilin, L K; Gladkov, D; Glasman, C; Gogota, O; Golubkov, Yu A; Göttlicher, P; Grabowska-Bołd, I; Grebenyuk, J; Gregor, I; Grigorescu, G; Grzelak, G; Gueta, O; Gwenlan, C; Haas, T; Hain, W; Hamatsu, R; Hart, J C; Hartmann, H; Hartner, G; Hilger, E; Hochman, D; Hori, R; Horton, K; Hüttmann, A; Iacobucci, G; Ibrahim, Z A; Iga, Y; Ingbir, R; Ishitsuka, M; Jakob, H -P; Januschek, F; Jimenez, M; Jones, T W; Jüngst, M; Kadenko, I; Kahle, B; Kamaluddin, B; Kananov, S; Kanno, T; Karshon, U; Karstens, F; Katkov, I I; Kaur, M; Kaur, P; Keramidas, A; Khein, L A; Kim, J Y; Kisielewska, D; Kitamura, S; Klanner, R; Klein, U; Koffeman, E; Kooijman, P; Korol, Ie; Korzhavina, I A; Kotański, A; Kötz, U; Kowalski, H; Kulinski, P; Kuprash, O; Kuze, M; Lee, A; Levchenko, B B; Levy, A; Libov, V; Limentani, S; Ling, T Y; Lisovyi, M; Lobodzinska, E; Lohmann, W; Löhr, B; Lohrmann, E; Loizides, J H; Long, K R; Longhin, A; Lontkovskyi, D; Lukina, O Yu; Łużniak, P; Maeda, J; Magill, S; Makarenko, I; Malka, J; Mankel, R; Margotti, A; Marini, G; Martin, J F; Mastroberardino, A; Mattingly, M C K; Melzer-Pellmann, I -A; Mergelmeyer, S; Miglioranzi, S; Idris, F Mohamad; Monaco, V; Montanari, A; Morris, J D; Mujkic, K; Musgrave, B; Nagano, K; Namsoo, T; Nania, R; Nicholass, D; Nigro, A; Ning, Y; Noor, U; Notz, D; Nowak, R J; Nuncio-Quiroz, A E; Oh, B Y; Okazaki, N; Oliver, K; Olkiewicz, K; Onishchuk, Yu; Papageorgiu, K; Parenti, A; Paul, E; Pawlak, J M; Pawlik, B; Pelfer, P G; Pellegrino, A; Perlanski, W; Perrey, H; Piotrzkowski, K; Plucinski, P; Pokrovskiy, N S; Polini, A; Proskuryakov, A S; Przybycień, M; Raval, A; Reeder, D D; Reisert, B; Ren, Z; Repond, J; Ri, Y D; Robertson, A; Roloff, P; Ron, E; Rubinsky, I; Ruspa, M; Sacchi, R; Salii, A; Samson, U; Sartorelli, G; Savin, A A; Saxon, D H; Schioppa, M; Schlenstedt, S; Schleper, P; Schmidke, W B; Schneekloth, U; Schönberg, V; Schörner-Sadenius, T; Schwartz, J; Sciulli, F; Shcheglova, L M; Shehzadi, R; Shimizu, S; Singh, I; Skillicorn, I O; Słomiński, W; Smith, W H; Sola, V; Solano, A; Son, D; Sosnovtsev, V; Spiridonov, A; Stadie, H; Stanco, L; Stern, A; Stewart, T P; Stifutkin, A; Stopa, P; Suchkov, S; Susinno, G; Suszycki, L; Sztuk-Dambietz, J; Szuba, D; Szuba, J; Tapper, A D; Tassi, E; Terrón, J; Theedt, T; Tiecke, H; Tokushuku, K; Tomalak, O; Tomaszewska, J; Tsurugai, T; Turcato, M; Tymieniecka, T; Uribe-Estrada, C; Vázquez, M; Verbytskyi, A; Viazlo, O; Vlasov, N N; Volynets, O; Walczak, R; Abdullah, W A T Wan; Whitmore, J J; Whyte, J; Wiggers, L; Wing, M; Wlasenko, M; Wolf, G; Wolfe, H; Wrona, K; Yagües-Molina, A G; Yamada, S; Yamazaki, Y; Yoshida, R; Youngman, C; Żarnecki, A F; Zawiejski, L; Zenaiev, O; Zeuner, W; Zhautykov, B O; Zhmak, N; Zhou, C; Zichichi, A; Zolko, M; Zotkin, D S; Zulkapli, Z

    2011-01-01

    The production of beauty quarks in ep interactions has been studied with the ZEUS detector at HERA for exchanged four-momentum squared Q^2 > 10 GeV^2, using an integrated luminosity of 363 pb^{-1}. The beauty events were identified using electrons from semileptonic b decays with a transverse momentum 0.9 < p_T^e < 8 GeV and pseudorapidity |eta^e| < 1.5. Cross sections for beauty production were measured and compared with next-to-leading-order QCD calculations. The beauty contribution to the proton structure function F_2 was extracted from the double-differential cross section as a function of Bjorken-x and Q^2.

  11. Measurement of beauty production in DIS and F_2^bbbar extraction at ZEUS

    CERN Document Server

    Abramowicz, H; Adamczyk, L; Adamus, M; Aggarwal, R; Antonelli, S; Antonioli, P; Antonov, A; Arneodo, M; Aushev, V; Aushev, Y; Bachynska, O; Bamberger, A; Barakbaev, A N; Barbagli, G; Bari, G; Barreiro, F; Bartsch, D; Basile, M; Behnke, O; Behr, J; Behrens, U; Bellagamba, L; Bertolin, A; Bhadra, S; Bindi, M; Blohm, C; Bold, T; Boos, E G; Borodin, M; Borras, K; Boscherini, D; Bot, D; Boutle, S K; Brock, I; Brownson, E; Brugnera, R; Bruemmer, N; Bruni, A; Bruni, G; Brzozowska, B; Bussey, P J; Butterworth, J M; Bylsma, B; Caldwell, A; Capua, M; Carlin, R; Catterall, C D; Chekanov, S; Chwastowski, J; Ciborowski, J; Ciesielski, R; Cifarelli, L; Cindolo, F; Contin, A; Cooper-Sarkar, A M; Coppola, N; Corradi, M; Corriveau, F; Costa, M; D'Agostini, G; Corso, F Dal; de Favereau, J; del Peso, J; Dementiev, R K; De Pasquale, S; Derrick, M; Devenish, R C E; Dobur, D; Dolgoshein, B A; Doyle, A T; Drugakov, V; Durkin, L S; Dusini, S; Eisenberg, Y; Ermolov, P F; Eskreys, A; Fang, S; Fazio, S; Ferrando, J; Ferrero, M I; Figiel, J; Forrest, M; Foster, B; Fourletov, S; Gach, G; Galas, A; Gallo, E; Garfagnini, A; Geiser, A; Gialas, I; Gladilin, L K; Gladkov, D; Glasman, C; Gogota, O; Golubkov, Yu A; Goettlicher, P; Grabowska-Bold, I; Grebenyuk, J; Gregor, I; Grigorescu, G; Grzelak, G; Gwenlan, C; Haas, T; Hain, W; Hamatsu, R; Hart, J C; Hartmann, H; Hartner, G; Hilger, E; Hochman, D; Holm, U; Hori, R; Horton, K; Huettmann, A; Iacobucci, G; Ibrahim, Z A; Iga, Y; Ingbir, R; Ishitsuka, M; Jakob, H -P; Januschek, F; Jimenez, M; Jones, T W; Juengst, M; Kadenko, I; Kahle, B; Kamaluddin, B; Kananov, S; Kanno, T; Karshon, U; Karstens, F; Katkov, I I; Kaur, M; Kaur, P; Keramidas, A; Khein, L A; Kim, J Y; Kisielewska, D; Kitamura, S; Klanner, R; Klein, U; Koffeman, E; Kollar, D; Kooijman, P; Korol, Ie; Korzhavina, I A; Kotanski, A; Koetz, U; Kowalski, H; Kulinski, P; Kuprash, O; Kuze, M; Kuzmin, V A; Lee, A; Levchenko, B B; Levy, A; Libov, V; Limentani, S; Ling, T Y; Lisovyi, M; Lobodzinska, E; Lohmann, W; Loehr, B; Lohrmann, E; Loizides, J H; Long, K R; Longhin, A; Lontkovskyi, D; Lukina, O Yu; Luzniak, P; Maeda, J; Magill, S; Makarenko, I; Malka, J; Mankel, R; Margotti, A; Marini, G; Martin, J F; Mastroberardino, A; Matsumoto, T; Mattingly, M C K; Melzer-Pellmann, I -A; Miglioranzi, S; Idris, F Mohamad; Monaco, V; Montanari, A; Morris, J D; Musgrave, B; Nagano, K; Namsoo, T; Nania, R; Nicholass, D; Nigro, A; Ning, Y; Noor, U; Notz, D; Nowak, R J; Nuncio-Quiroz, A E; Oh, B Y; Okazaki, N; Oliver, K; Olkiewicz, K; Onishchuk, Yu; Ota, O; Papageorgiu, K; Parenti, A; Paul, E; Pawlak, J M; Pawlik, B; Pelfer, P G; Pellegrino, A; Perlanski, W; Perrey, H; Piotrzkowski, K; Plucinski, P; Pokrovskiy, N S; Polini, A; Proskuryakov, A S; Przybycien, M; Raval, A; Reeder, D D; Reisert, B; Ren, Z; Repond, J; Ri, Y D; Robertson, A; Roloff, P; Ron, E; Rubinsky, I; Ruspa, M; Sacchi, R; Salii, A; Samson, U; Sartorelli, G; Savin, A A; Saxon, D H; Schioppa, M; Schlenstedt, S; Schleper, P; Schmidke, W B; Schneekloth, U; Schoenberg, V; Schoerner-Sadenius, T; Schwartz, J; Sciulli, F; Shcheglova, L M; Shehzadi, R; Shimizu, S; Singh, I; Skillicorn, I O; Slominski, W; Smith, W H; Sola, V; Solano, A; Son, D; Sosnovtsev, V; Spiridonov, A; Stadie, H; Stanco, L; Stern, A; Stewart, T P; Stifutkin, A; Stopa, P; Suchkov, S; Susinno, G; Suszycki, L; Sztuk, J; Szuba, D; Szuba, J; Tapper, A D; Tassi, E; Terron, J; Theedt, T; Tiecke, H; Tokushuku, K; Tomalak, O; Tomaszewska, J; Tsurugai, T; Turcato, M; Tymieniecka, T; Uribe-Estrada, C; Vazquez, M; Verbytskyi, A; Viazlo, V; Vlasov, N N; Volynets, O; Walczak, R; Abdullah, W A T Wan; Whitmore, J J; Whyte, J; Wiggers, L; Wing, M; Wlasenko, M; Wolf, G; Wolfe, H; Wrona, K; Yagues-Molina, A G; Yamada, S; Yamazaki, Y; Yoshida, R; Youngman, C; Zarnecki, A F; Zawiejski, L; Zenaiev, O; Zeuner, W; Zhautykov, B O; Zhmak, N; Zhou, C; Zichichi, A; Zolko, M; Zotkin, D S; Zulkapli, Z

    2010-01-01

    Beauty production in deep inelastic scattering with events in which a muon and a jet are observed in the final state has been measured with the ZEUS detector at HERA using an integrated luminosity of 114 pb^-1. The fraction of events with beauty quarks in the data was determined using the distribution of the transverse momentum of the muon relative to the jet. The cross section for beauty production was measured in the kinematic range of photon virtuality, Q^2 > 2 Gev^2, and inelasticity, 0.05 < y < 0.7, with the requirement of a muon and a jet. Total and differential cross sections are presented and compared to QCD predictions. The beauty contribution to the structure function F_2 was extracted and is compared to theoretical predictions.

  12. Truth and beauty in cosmology: does the Universe have an aesthetic?

    CERN Multimedia

    Impey, C

    2004-01-01

    "Astronomy is an empirical science, yet scientific definitions of truth and beauty are closely tied to the fact that mathematics appears to provide an accurate description of the physical Universe" (2 pages)

  13. Measurement of beauty production in deep inelastic scattering at HERA using decays into electrons

    Energy Technology Data Exchange (ETDEWEB)

    Abramowicz, H.; Gueta, O.; Ingbir, R.; Kananov, S.; Levy, A.; Stern, A. [Tel Aviv Univ., Raymond and Beverly Sackler Faculty of Exact Sciences, School of Physics, Tel Aviv (Israel); Abt, I.; Caldwell, A.; Reisert, B.; Schmidke, W.B. [Max-Planck-Inst. fuer Physik, Muenchen (Germany); Adamczyk, L.; Bold, T.; Gach, G.; Grabowska-Bold, I.; Kisielewska, D.; Przybycien, M.; Suszycki, L. [AGH-Univ. of Science and Technology, Faculty of Physics and Applied Computer Science, Cracow (Poland); Adamus, M.; Plucinski, P.; Tymieniecka, T. [Inst. for Nuclear Studies, Warsaw (Poland); Aggarwal, R.; Kaur, M.; Kaur, P.; Singh, I. [Panjab Univ., Dept. of Physics, Chandigarh (India); Antonelli, S.; Basile, M.; Bindi, M.; Cifarelli, L.; Contin, A.; De Pasquale, S.; Sartorelli, G.; Zichichi, A. [Univ. Bologna (Italy); INFN Bologna (Italy); Antonioli, P.; Bari, G.; Bellagamba, L.; Boscherini, D.; Bruni, A.; Bruni, G.; Cindolo, F.; Corradi, M.; Iacobucci, G.; Margotti, A.; Nania, R.; Polini, A. [INFN Bologna (Italy); Antonov, A.; Dolgoshein, B.A.; Gladkov, D.; Sosnovtsev, V.; Stifutkin, A.; Suchkov, S. [Moscow Engineering Physics Inst., Moscow (Russian Federation); Arneodo, M.; Ruspa, M. [Univ. del Piemonte Orientale, Novara (Italy); INFN, Torino (Italy); Aushev, V.; Dolinska, G.; Gogota, O.; Korol, I.; Viazlo, O. [National Academy of Sciences, Inst. for Nuclear Research, Kyiv (Ukraine); National Taras Shevchenko Univ. of Kyiv, Dept. of Nuclear Physics, Kyiv (Ukraine); Aushev, Y.; Bartosik, N.; Bolilyi, O.; Kadenko, I.; Kuprash, O.; Lontkovskyi, D.; Makarenko, I.; Onishchuk, Y.; Salii, A.; Tomalak, O.; Volynets, O.; Zenaiev, O.; Zolko, M. [National Taras Shevchenko Univ. of Kyiv, Dept. of Nuclear Physics, Kyiv (Ukraine); Bachynska, O.; Behnke, O.; Behr, J.; Behrens, U.; Blohm, C.; Borras, K.; Bot, D.; Ciesielski, R.; Coppola, N.; Fang, S.; Geiser, A.; Goettlicher, P.; Grebenyuk, J.; Gregor, I.; Haas, T.; Hain, W.; Huettmann, A.; Januschek, F.; Kahle, B. [and others

    2011-02-15

    The production of beauty quarks in ep interactions has been studied with the ZEUS detector at HERA for exchanged four-momentum squared Q{sup 2}>10 GeV{sup 2}, using an integrated luminosity of 363 pb{sup -1}. The beauty events were identified using electrons from semileptonic b decays with a transverse momentum 0.9beauty production were measured and compared with next-to-leading-order QCD calculations. The beauty contribution to the proton structure function F{sub 2} was extracted from the double-differential cross section as a function of Bjorken-x and Q{sup 2}. (orig.)

  14. Beauty photoproduction measured from inclusive dijet events in ep collisions at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Yagues, Ana [DESY, Hamburg (Germany)

    2008-07-01

    The production of b quarks is being studied in dijet events in photoproduction (Q{sup 2}<1 GeV{sup 2}) with the ZEUS detector at HERA using an integrated luminosity of 133 pb{sup -1}. The installed micro-vertex detector (MVD) is used to determine the beauty fraction from measurements of the secondary vertex position with respect to the primary vertex. The heavy mass of the beauty quark and its long lifetime is exploited to separate beauty signal from background. The beauty fraction is extracted statistically using the decay length significance and invariant mass distributions. The total cross section and differential cross sections d{sigma}/dp{sup b}{sub T} and d{sigma}/d{eta}{sup b} are measured and compared to previous measurements and next-to-leading order OCD predictions.

  15. Beauty production and F{sub 2}{sup bb}-bar at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Corradi, Massimo, E-mail: massimo.corradi@bo.infn.i [INFN Bologna, via Irnerio 46, Bologna (Italy)

    2009-06-15

    The status of beauty measurements at HERA is reviewed. A considerable improvement in the precision and kinematic coverage has been achieved in the last years. The results are in good agreement with NLO QCD.

  16. Measurement of beauty production in deep inelastic scattering at HERA using decays into electrons

    Energy Technology Data Exchange (ETDEWEB)

    Shehzadi, Ramoona

    2011-01-15

    The production of beauty quarks in ep interactions has been studied with the ZEUS detector at HERA for exchanged four-momentum squared Q{sup 2}>10 GeV{sup 2}, using an integrated luminosity of 363 pb{sup -1}. The beauty events were identified using electrons from semileptonic b decays with a transverse momentum 0.9beauty production were measured and compared with next-to-leading-order QCD calculations. The beauty contribution to the proton structure function F{sub 2} was extracted from the double-differential cross section as a function of Bjorken-x and Q{sup 2}. (orig.)

  17. Measurement of beauty production in deep inelastic scattering at HERA using decays into electrons

    Energy Technology Data Exchange (ETDEWEB)

    Abramowicz, H. [Tel Aviv Univ. (Israel). School of Physics; Max-Planck-Institut fuer Physik, Muenchen (Germany); Abt, I. [Max-Planck-Institut fuer Physik, Muenchen (Germany); Adamczyk, L. [AGH-Univ. of Science and Technology, Cracow (PL). Faculty of Physics and Applied Computer Science] (and others)

    2011-01-15

    The production of beauty quarks in ep interactions has been studied with the ZEUS detector at HERA for exchanged four-momentum squared Q{sup 2}>10 GeV{sup 2}, using an integrated luminosity of 363 pb{sup -1}. The beauty events were identified using electrons from semileptonic b decays with a transverse momentum 0.9 beauty production were measured and compared with next-to-leading-order QCD calculations. The beauty contribution to the proton structure function F{sub 2} was extracted from the double-differential cross section as a function of Bjorken-x and Q{sup 2}. (orig.)

  18. Altered Images: Understanding the Influence of Unrealistic Images and Beauty Aspirations.

    Science.gov (United States)

    MacCallum, Fiona; Widdows, Heather

    2016-07-18

    In this paper we consider the impact of digitally altered images on individuals' body satisfaction and beauty aspirations. Drawing on current psychological literature we consider interventions designed to increase knowledge about the ubiquity and unreality of digital images and, in the form of labelling, provide information to the consumer. Such interventions are intended to address the negative consequences of unrealistic beauty ideals. However, contrary to expectations, such initiatives may not be effective, especially in the long-term, and may even be counter-productive. We seek to understand this phenomenon of our continued aspiration for beauty ideals we know to be unreal and even impossible. We draw on our respective disciplines to offer psychological and philosophical accounts for why this might be. We conclude that beauty ideals are deeply embedded in our aspirations, practices, and in our constructions of ourselves. Given this, it is not surprising that simply increasing knowledge, or providing information, will be insufficient to challenge them.

  19. Simple Algorithmic Principles of Discovery, Subjective Beauty, Selective Attention, Curiosity & Creativity

    CERN Document Server

    Schmidhuber, Juergen

    2007-01-01

    I postulate that human or other intelligent agents function or should function as follows. They store all sensory observations as they come - the data is holy. At any time, given some agent's current coding capabilities, part of the data is compressible by a short and hopefully fast program / description / explanation / world model. In the agent's subjective eyes, such data is more regular and more "beautiful" than other data. It is well-known that knowledge of regularity and repeatability may improve the agent's ability to plan actions leading to external rewards. In absence of such rewards, however, known beauty is boring. Then "interestingness" becomes the first derivative of subjective beauty: as the learning agent improves its compression algorithm, formerly apparently random data parts become subjectively more regular and beautiful. Such progress in compressibility is measured and maximized by the curiosity drive: create action sequences that extend the observation history and yield previously unknown /...

  20. "Wonderful, heavenly, beautiful, and ours": lesbian fantasy and media(ted) desire in Heavenly Creatures.

    Science.gov (United States)

    Scahill, Andrew

    2012-01-01

    Peter Jackson's Heavenly Creatures (1994) is the story of two girls in New Zealand who form an intense erotic friendship based on a fantasy world they create, and how their forced separation leads them to commit matricide. Beneath the sensational surface, though, is another story: this is a film about cinema, about desire, and how queer spectators create new and unexpected meanings. This article argues that Heavenly Creatures is a queer love letter to the power of cinema, revealing how queer consciousness may indeed be constituted from foreclosed possibility by the medium--providing a landscape, a stage, and a mise-en-scène of desire.

  1. Relationships between women beauty and health: a look from female teachers of physical education perspective

    Directory of Open Access Journals (Sweden)

    Angélica Teixeira da Silva Leitzke

    2014-11-01

    Full Text Available This descriptive qualitative research aimed to discuss possible Culture Industry Influences, as well as the actual consumption logic into the relationships between woman beauty and health from a study realized with 20 female physical education teachers of Goiania/GO public schools. Their information indicate the approach between beauty and health concepts and marks of a fetishization and reification historic process of women body. However, it is perceived movements of contradiction and resistance to the imposed standards.

  2. [Comparison the phenomenon of smoking cigarettes among cosmetology students and personnel beauty salon from Podlaskie county].

    Science.gov (United States)

    Jaszczuk, Agata; Kleszczewska, Ewa

    2009-01-01

    The aim of the study was to learn the attitude towards tobacco smoking of cosmetology students and personnel of beauty salon. This study was one of the results of the Preventive Medicine Program implemented at the University of Cosmetology and Health Care in Bialystok. Data was collected through questionnaire which was filled individually and independently by each respondent and additionally anonymity was guaranteed. Research covered group of 98 students and 100 women working in beauty salons.

  3. Billiards and Brains: Cognitive Ability and Behavior in a p-Beauty Contest

    OpenAIRE

    Terence C. Burnham; Cesarini, David; Wallace, Björn; Johannesson, Magnus; Lichtenstein, Paul

    2007-01-01

    "Beauty contests" are well-studied, dominance-solvable games that generate two interesting results. First, most behavior does not conform to the unique Nash equilibrium. Second, there is considerable unexplained heterogeneity in behavior. In this work, we evaluate the relationship between beauty contest behavior and cognitive ability. We find that subjects with high cognitive ability exhibit behavior that is closer to the Nash equlibrium. We examine this finding through the prism of economic ...

  4. Billiards and brains: Cognitive ability and behaviour in a p-beauty contest

    OpenAIRE

    Terence C. Burnham; Cesarini, David; Wallace, Björn

    2007-01-01

    Beauty contests are well-studied, dominance-solvable games that generate two interesting results. First, most behavior does not conform to the unique Nash equilibrium. Second, there is considerable unexplained heterogeneity in behavior. In this work, we evaluate the relationship between beauty contest behavior and cognitive ability. We find that subjects with high cognitive ability exhibit behavior that is closer to the Nash equlibrium. We examine this finding through the prism of economic an...

  5. Detection of Fungi in Hair-brushes in Beauty Salons at Jatinangor

    Directory of Open Access Journals (Sweden)

    Susanna Mitchelle Edward

    2015-12-01

    Full Text Available Background: Various beauty tools are used in beauty salons, among those is the hair-brush. The hair-brush can conceal various human skin pathogens although under harsh environmental conditions, most pathogens are killed; nevertheless, few microorganisms, such as the fungi can adapt and survive. Moreover, the moist conditions of the hair-brush predisposes the growth of fungi however the ability of these fungi to instigate disease in an individual is dependent on the portal of entry and the host immunological status. This study was conducted to determine the fungus that is present in the beauty salon’s hair-brushes. Methods: This study was conducted in beauty salons located in Jatinangor area during September–October 2013 using the descriptive laboratory method. Fifteen beauty salons were included in this study based on sample size calculation for dichotomous variable. The specimens from all the hair-brushes were collected after the owner’s informed consent, then cultured onto 30 sabouraud agar, two for each beauty salon (dermatophyte and non-dermatophyte agar. The fungi were detected macroscopically and microscopically. Results: Overall, 93% revealed to be culture positive, with 90% of them were found to be non-dermatophytes, most of which are saprophytic fungi. The remaining 3% were dermatophytes. Conclusions: Beauty salon’s hair-brushes contain a wide range of fungi distribution which may be a source of fungal colonization. However, most of the fungi found in the beauty salons are saprophytic fungi, therefore it is unnecessary to be anxious about a small amount of pathogenic fungi are found in humans.

  6. Contributions of Consumer-perceived Creativity and Beauty to Willingness-to-pay for Design Products

    DEFF Research Database (Denmark)

    Christensen, Bo Thomas; Kristensen, Tore; Reber, Rolf

    2015-01-01

    Consumer perception of creativity in design products equivalent in function was measured using global single-item ratings of creativity. The measure was found to have a high level of agreement between raters and have discriminant validity to another aesthetic construct, that of beauty. In two exp...... models of creativity and beauty evaluations in consumer psychology, in that they seem to be distinct factors, explaining different parts of the variance in their consequences on WtP....

  7. A study of the prevalence of respiratory morbidity and ventilatory obstruction in beauty parlour workers

    Directory of Open Access Journals (Sweden)

    Kesavachandran C

    2006-01-01

    Full Text Available A study was conducted in beauty parlor workers of Lucknow, India, to assess the prevalence of respiratory morbidity and lung function abnormalities compared to their control subjects belonging to the same socioeconomic status and ethnic group, having never been exposed to the workplace of beauty parlor and having not used any cosmetics. Respiratory morbidity and bronchial obstruction based on PEFR study was conducted in 196 beauty parlor workers and 35 control subjects. All the participants were non-smokers and were matched for age, height, weight and socioeconomic status. Peak expiratory flow rate were performed using Peak Flow meter. Symptomatic workers showed bronchial obstruction (28%, and this prevalence was significantly higher ( P P < 0.01 than male workers (1.42. Overall respiratory morbidity among beauty parlor workers showed higher (12.7% when compared with control group (2.8% but differences couldn′t attain any significance. Although nonsignificant, workers in beauty parlor showed more prevalence (9.4% of bronchial obstruction based on PEFR than controls (4%. This study showed that beauty parlor workers were more prone to respiratory morbidity and lung function abnormalities, as the study group selected were non-smokers.

  8. The Functional and Three Beauty Theory: An Alternative Perspective on the Chinese Translation of English Advertisement

    Directory of Open Access Journals (Sweden)

    Lee Pin Ling

    2016-10-01

    Full Text Available Considering the multiracial, multicultural and multilingual background of the readers in Malaysia, it is very common to find advertisements with exactly the same graphics but in different languages. From the survey of previous studies, it is found that the Chinese translation of English advertisement in Malaysia has not received adequate attention from researchers. Apart from this, it is found that the adoption of the Three Beauty Theory into the translation of advertisement has not captured much attention from researchers. Thus, this study attempts to fill this gap by looking into the Chinese translation of English advertisement in Malaysian newspapers, based on the Functional Translation Theory and the Three Beauty Theory. The result of this study shows that the use of three aspects of Chinese language (meaning, sound and form in analysing and identifying the appellativeness of a Chinese translated English headline is appropriate. In addition to that, the effectiveness of Chinese translation of English advertisement headline, in terms of meaning, sound and form could be analysed and improved, based on the Three Beauty Theory. In short, the Functional Translation Theories provides a guideline on the purpose of translation, typology, and language function and translation strategy in the Chinese translation of English advertisement. On the other hand, the Three Beauty Theory safeguards the effectiveness and the beauty of Chinese language, in terms of meaning (idea, message, form (structure and sound (phonology. Keywords: Chinese translation, English advertisement, Functional Translation Theory, Three Beauty Theory

  9. Socio-economic Conditions of Tribal Female Workers of the Beauty Parlors in Bangladesh

    Directory of Open Access Journals (Sweden)

    Nargis Akhter

    2011-05-01

    Full Text Available The study highlights the socio-economic conditions of tribal female workers of the beauty parlors in Bangladesh. The study consists of 240 sample tribal female workers of the different beauty parlors situated in six divisional towns of Bangladesh and judgment sampling technique was used to select this sample. The study reveals that tribal women working at beauty parlor draw competitively higher salary than other tribal people; they live at a comparatively healthy physical environment provided by their owners. Majority of the respondents mentioned that their earnings have improved their economic condition significantly and more than half of them have past work experience of the same job. The tribal female workers of the beauty parlors in Bangladesh are not only generating income from the beauty parlors they are providing a valuable service to the new consumer society. The main stream society is not yet ready to provide this type of services. So, we should not treat this migrant community as temporary visitors rather we should treat them as indispensable and contributing factor of the social and economic development in Bangladesh. There should be initiative from the government of Bangladesh to inspect health; safety; welfare and other related issues of the beauty parlors in Bangladesh and take necessary actions in this regard. Finally, the future research directions are presented.

  10. Nennu and Shunu: gender, body politics, and the beauty economy in China.

    Science.gov (United States)

    Yang, Jie

    2011-01-01

    This essay analyzes recent discourse on two emerging representations of women in China, "tender" women (nennu) and "ripe" women (shunu), in order to examine the relationships among gender, body politics, and consumerism. The discourse of nennu and shunu suggests that older, ripe women become younger and more tender by consuming fashions, cosmetic surgery technologies, and beauty and health care products and services because tender women represent the ideal active consumership that celebrates beauty, sexuality, and individuality. This discourse serves to enhance consumers' desire for beauty and health and to ensure the continued growth of China's beauty economy and consumer capitalism. Highlighting the role of the female body, feminine beauty, and feminine youth in developing consumerism, this discourse downplays the contributions of millions of beauty and health care providers (predominantly laid-off female workers and rural migrant women) and new forms of gender exploitation. Such an overemphasis on gender masks intensified class division. This essay suggests that women and their bodies become new terrains from which post-Mao China can draw its power and enact consumerism. Gender constitutes both an economic multiplier to boost China's consumer capitalism and a biopolitical strategy to regulate and remold women and their bodies into subjects that are identified with the state's political and economic objectives. Since consumerism has been incorporated into China's nation-building project, gender thus becomes a vital resource for both consumer capitalist development and nation building. This essay shows that both gender and the body are useful analytic categories for the study of postsocialism.

  11. Host modulation by therapeutic agents

    Directory of Open Access Journals (Sweden)

    Sugumari Elavarasu

    2012-01-01

    Full Text Available Periodontal disease susceptible group present advanced periodontal breakdown even though they achieve a high standard of oral hygiene. Various destructive enzymes and inflammatory mediators are involved in destruction. These are elevated in case of periodontal destruction. Host modulation aims at bringing these enzymes and mediators to normal level. Doxycycline, nonsteroidal anti-inflammatory drugs (NSAIDs, bisphosphonates, nitrous oxide (NO synthase inhibitors, recombinant human interleukin-11 (rhIL-11, omega-3 fatty acid, mouse anti-human interleukin-6 receptor antibody (MRA, mitogen-activated protein kinase (MAPK inhibitors, nuclear factor-kappa B (NF-kb inhibitors, osteoprotegerin, and tumor necrosis factor antagonist (TNF-α are some of the therapeutic agents that have host modulation properties.

  12. Somatic mutagenesis with a Sleeping Beauty transposon system leads to solid tumor formation in zebrafish.

    Directory of Open Access Journals (Sweden)

    Maura McGrail

    Full Text Available Large-scale sequencing of human cancer genomes and mouse transposon-induced tumors has identified a vast number of genes mutated in different cancers. One of the outstanding challenges in this field is to determine which genes, when mutated, contribute to cellular transformation and tumor progression. To identify new and conserved genes that drive tumorigenesis we have developed a novel cancer model in a distantly related vertebrate species, the zebrafish, Danio rerio. The Sleeping Beauty (SB T2/Onc transposon system was adapted for somatic mutagenesis in zebrafish. The carp ß-actin promoter was cloned into T2/Onc to create T2/OncZ. Two transgenic zebrafish lines that contain large concatemers of T2/OncZ were isolated by injection of linear DNA into the zebrafish embryo. The T2/OncZ transposons were mobilized throughout the zebrafish genome from the transgene array by injecting SB11 transposase RNA at the 1-cell stage. Alternatively, the T2/OncZ zebrafish were crossed to a transgenic line that constitutively expresses SB11 transposase. T2/OncZ transposon integration sites were cloned by ligation-mediated PCR and sequenced on a Genome Analyzer II. Between 700-6800 unique integration events in individual fish were mapped to the zebrafish genome. The data show that introduction of transposase by transgene expression or RNA injection results in an even distribution of transposon re-integration events across the zebrafish genome. SB11 mRNA injection resulted in neoplasms in 10% of adult fish at ∼10 months of age. T2/OncZ-induced zebrafish tumors contain many mutated genes in common with human and mouse cancer genes. These analyses validate our mutagenesis approach and provide additional support for the involvement of these genes in human cancers. The zebrafish T2/OncZ cancer model will be useful for identifying novel and conserved genetic drivers of human cancers.

  13. Sleeping Beauty transposon mutagenesis identifies genes that cooperate with mutant Smad4 in gastric cancer development.

    Science.gov (United States)

    Takeda, Haruna; Rust, Alistair G; Ward, Jerrold M; Yew, Christopher Chin Kuan; Jenkins, Nancy A; Copeland, Neal G

    2016-04-05

    Mutations in SMAD4 predispose to the development of gastrointestinal cancer, which is the third leading cause of cancer-related deaths. To identify genes driving gastric cancer (GC) development, we performed a Sleeping Beauty (SB) transposon mutagenesis screen in the stomach of Smad4(+/-) mutant mice. This screen identified 59 candidate GC trunk drivers and a much larger number of candidate GC progression genes. Strikingly, 22 SB-identified trunk drivers are known or candidate cancer genes, whereas four SB-identified trunk drivers, including PTEN, SMAD4, RNF43, and NF1, are known human GC trunk drivers. Similar to human GC, pathway analyses identified WNT, TGF-β, and PI3K-PTEN signaling, ubiquitin-mediated proteolysis, adherens junctions, and RNA degradation in addition to genes involved in chromatin modification and organization as highly deregulated pathways in GC. Comparative oncogenomic filtering of the complete list of SB-identified genes showed that they are highly enriched for genes mutated in human GC and identified many candidate human GC genes. Finally, by comparing our complete list of SB-identified genes against the list of mutated genes identified in five large-scale human GC sequencing studies, we identified LDL receptor-related protein 1B (LRP1B) as a previously unidentified human candidate GC tumor suppressor gene. In LRP1B, 129 mutations were found in 462 human GC samples sequenced, and LRP1B is one of the top 10 most deleted genes identified in a panel of 3,312 human cancers. SB mutagenesis has, thus, helped to catalog the cooperative molecular mechanisms driving SMAD4-induced GC growth and discover genes with potential clinical importance in human GC.

  14. Beauty is in the eye of the photographer

    CERN Multimedia

    Roberto Cantoni

    2010-01-01

    On Saturday 7 August, over 200 amateur photographers took part in the first “Particle Physics Photowalk”, a photo contest organized by CERN in collaboration with DESY in Germany, Fermilab in the USA, KEK in Japan and TRIUMF in Canada. As of mid-September you will be able to discover on a dedicated website the five particle physics laboratories as seen through the lenses of the participants.   Photographers at the photowalk. The Photowalk was a unique opportunity for the participants to photograph state-of-the-art accelerators and detectors in all their beauty and complexity. At CERN, the photographers were able to visit and take pictures of Linac4, the Computing Centre, SM18 and CLIC. Photographers came to CERN from Switzerland, France, the UK and Germany (one even came from the USA just for the event). “The 48 places available for the Photowalk at CERN were snatched up within days through the dedicated website”, says Sophie Tesauri from the Communication G...

  15. Regulated complex assembly safeguards the fidelity of Sleeping Beauty transposition

    Science.gov (United States)

    Wang, Yongming; Pryputniewicz-Dobrinska, Diana; Nagy, Enikö Éva; Kaufman, Christopher D.; Singh, Manvendra; Yant, Steve; Wang, Jichang; Dalda, Anna; Kay, Mark A.; Ivics, Zoltán; Izsvák, Zsuzsanna

    2017-01-01

    The functional relevance of the inverted repeat structure (IR/DR) in a subgroup of the Tc1/mariner superfamily of transposons has been enigmatic. In contrast to mariner transposition, where a topological filter suppresses single-ended reactions, the IR/DR orchestrates a regulatory mechanism to enforce synapsis of the transposon ends before cleavage by the transposase occurs. This ordered assembly process shepherds primary transposase binding to the inner 12DRs (where cleavage does not occur), followed by capture of the 12DR of the other transposon end. This extra layer of regulation suppresses aberrant, potentially genotoxic recombination activities, and the mobilization of internally deleted copies in the IR/DR subgroup, including Sleeping Beauty (SB). In contrast, internally deleted sequences (MITEs) are preferred substrates of mariner transposition, and this process is associated with the emergence of Hsmar1-derived miRNA genes in the human genome. Translating IR/DR regulation to in vitro evolution yielded an SB transposon version with optimized substrate recognition (pT4). The ends of SB transposons excised by a K248A excision+/integration- transposase variant are processed by hairpin resolution, representing a link between phylogenetically, and mechanistically different recombination reactions, such as V(D)J recombination and transposition. Such variants generated by random mutation might stabilize transposon-host interactions or prepare the transposon for a horizontal transfer. PMID:27913727

  16. Psychosocial aspects of beauty: how and why to look good.

    Science.gov (United States)

    Koblenzer, Caroline S

    2003-01-01

    It is difficult to pick up a paper or magazine today or turn on the television without being reminded that ours is a culture of youth and beauty. Bookstore shelves sag under the weight of enticing tomes devoted to the subject. We are bombarded with advertisements for any one of thousands of different products, both prescription and over-the-counter, that claim to be able to restore our youthful appearance, banish wrinkles, tone skin, and remove cellulite, among other promises that often sound, and probably are, too good to be true. Health food stores and sales catalogs are replete with myriad products, so that one wonders how the average person, in face of such bombardment, can either resist the temptation to buy or make an informed selection from the veritable feast of goodies put before them. Billions of dollars are expended each year, and false claims abound, but fortunately, there are many preparations and procedures that, in skilled hands, can really make a difference.

  17. Rare beauty and charm decays with the CMS experiment

    Directory of Open Access Journals (Sweden)

    Chen Kai-Feng

    2013-05-01

    Full Text Available Rare beauty meson decays Bs0 → µ+µ−, B0 → μ+μ−, and charm meson decays D0 → μ+μ− are searched in pp collisions at √s = 7 TeV. A data sample corresponding to an integrated luminosity of 5 fb−1 collected by the CMS experiment is used for the B → μ+μ− study, while the data sample used for D0 → μ+μ− search is 90 pb−1. The number of events observed after applying the full selection criteria is consistent with the expectations from the sum of background and standard model signal. The resulting upper limits on the branching fractions are ℬ(Bs0 → µ+µ− < 7.7 × 10−9, ℬ(B0 µ+ µ− < 1.8 × 10−9 at 95% confidence level, and ℬ(D0 → μ+μ− < 5.4 × 10−7 at 90% confidence level.

  18. Sleeping Beauty Mouse Models Identify Candidate Genes Involved in Gliomagenesis

    Science.gov (United States)

    Vyazunova, Irina; Maklakova, Vilena I.; Berman, Samuel; De, Ishani; Steffen, Megan D.; Hong, Won; Lincoln, Hayley; Morrissy, A. Sorana; Taylor, Michael D.; Akagi, Keiko; Brennan, Cameron W.; Rodriguez, Fausto J.; Collier, Lara S.

    2014-01-01

    Genomic studies of human high-grade gliomas have discovered known and candidate tumor drivers. Studies in both cell culture and mouse models have complemented these approaches and have identified additional genes and processes important for gliomagenesis. Previously, we found that mobilization of Sleeping Beauty transposons in mice ubiquitously throughout the body from the Rosa26 locus led to gliomagenesis with low penetrance. Here we report the characterization of mice in which transposons are mobilized in the Glial Fibrillary Acidic Protein (GFAP) compartment. Glioma formation in these mice did not occur on an otherwise wild-type genetic background, but rare gliomas were observed when mobilization occurred in a p19Arf heterozygous background. Through cloning insertions from additional gliomas generated by transposon mobilization in the Rosa26 compartment, several candidate glioma genes were identified. Comparisons to genetic, epigenetic and mRNA expression data from human gliomas implicates several of these genes as tumor suppressor genes and oncogenes in human glioblastoma. PMID:25423036

  19. Regulated complex assembly safeguards the fidelity of Sleeping Beauty transposition.

    Science.gov (United States)

    Wang, Yongming; Pryputniewicz-Dobrinska, Diana; Nagy, Enikö Éva; Kaufman, Christopher D; Singh, Manvendra; Yant, Steve; Wang, Jichang; Dalda, Anna; Kay, Mark A; Ivics, Zoltán; Izsvák, Zsuzsanna

    2017-01-09

    The functional relevance of the inverted repeat structure (IR/DR) in a subgroup of the Tc1/mariner superfamily of transposons has been enigmatic. In contrast to mariner transposition, where a topological filter suppresses single-ended reactions, the IR/DR orchestrates a regulatory mechanism to enforce synapsis of the transposon ends before cleavage by the transposase occurs. This ordered assembly process shepherds primary transposase binding to the inner 12DRs (where cleavage does not occur), followed by capture of the 12DR of the other transposon end. This extra layer of regulation suppresses aberrant, potentially genotoxic recombination activities, and the mobilization of internally deleted copies in the IR/DR subgroup, including Sleeping Beauty (SB). In contrast, internally deleted sequences (MITEs) are preferred substrates of mariner transposition, and this process is associated with the emergence of Hsmar1-derived miRNA genes in the human genome. Translating IR/DR regulation to in vitro evolution yielded an SB transposon version with optimized substrate recognition (pT4). The ends of SB transposons excised by a K248A excision(+)/integration(-) transposase variant are processed by hairpin resolution, representing a link between phylogenetically, and mechanistically different recombination reactions, such as V(D)J recombination and transposition. Such variants generated by random mutation might stabilize transposon-host interactions or prepare the transposon for a horizontal transfer.

  20. Cosmetic Surgery: Regulatory Challenges in a Global Beauty Market.

    Science.gov (United States)

    Griffiths, Danielle; Mullock, Alex

    2017-02-28

    The market for cosmetic surgery tourism is growing with an increase in people travelling abroad for cosmetic surgery. While the reasons for seeking cosmetic surgery abroad may vary the most common reason is financial, but does cheaper surgery abroad carry greater risks? We explore the risks of poorly regulated cosmetic surgery to society generally before discussing how harm might be magnified in the context of cosmetic tourism, where the demand for cheaper surgery drives the market and makes surgery accessible for increasing numbers of people. This contributes to the normalisation of surgical enhancement, creating unhealthy cultural pressure to undergo invasive and risky procedures in the name of beauty. In addressing the harms of poorly regulated surgery, a number of organisations purport to provide a register of safe and ethical plastic surgeons, yet this arguably achieves little and in the absence of improved regulation the risks are likely to grow as the global market expands to meet demand. While the evidence suggests that global regulation is needed, the paper concludes that since a global regulatory response is unlikely, more robust domestic regulation may be the best approach. While domestic regulation may increase the drive towards foreign providers it may also have a symbolic effect which will reduce this drive by making people more aware of the dangers of surgery, both to society and individual physical wellbeing.

  1. Re-enchanted by beauty. On aesthetics and mysticism

    Directory of Open Access Journals (Sweden)

    Pieter G.R. de Villiers

    2016-05-01

    Full Text Available The article investigates the potential of mysticism to revitalise theology. It firstly traces howaesthetics was understood in theology and provides reasons for this view. It then investigateshow the predominant epistemological approach in theology privileged conceptual knowledgeand relativised aesthetics as being subjective and therefore unreliable. It gives special attentionto this epistemology by spelling out how the intellectualisation of contemporary theologyintensified the process of obfuscating and sidelining aesthetics. In a third part, the article spellsout the consequences of this position by analysing how theology is becoming a disenchantedenterprise. The article then investigates how aesthetics often is taking over the role of theologyand its formative role in social discourse. It focuses on the epistemological nature of this turntowards aesthetics, arguing that aesthetics with its profound notion of beauty (with goodnessand joy as its corollaries, is increasingly reappraised as a legitimate, but different kind andsource of knowledge. The article then argues how aesthetics can reinvigorate theology as asource of knowledge together with conceptual knowledge. It ends by investigating howtheology can be re-enchanted by learning from the prominent role and invigorating forms ofaesthetics in mysticism.

  2. Hawaiian Starlight: Sharing the Beauty of the Hawaiian Skies

    Science.gov (United States)

    Cuillandre, J. C.

    Canada-France-Hawaii Telescope Corp. The summit of Mauna Kea (14,000 feet) offers the best viewing of the Cosmos in the northern hemisphere, and the film "Hawaiian Starlight" delivers a pure esthetic experience from the mountain into the Universe. Seven years in the making, this cinematic symphony reveals the spectacular beauty of the mountain and its connection to the Cosmos through the magical influence of time-lapse cinematography scored exclusively (no narration) with the awe-inspiring, critically acclaimed, Halo music by Martin O'Donnell and Michael Salvatori. Daytime and nighttime landscapes and skyscapes alternate with stunning true color images of the Universe captured by an observatory on Mauna Kea, all free of any computer generated imagery. An extended segment of the film will be presented at the Advanced Maui Optical and Space Surveillance Technologies Conference to celebrate the international year of Astronomy 2009, a global effort initiated by the IAU (International Astronomical Union) and UNESCO (United Nations Educational, Scientific and Cultural Organization) to help the citizens of the world rediscover their place in the Universe through the day- and night-time sky, and thereby engage a personal sense of wonder and discovery. Hawaiian Starlight is true to this commitment. The inspiration and technology of the film will be shortly presented by the film's director.

  3. DIRECTIVE SPEECH ACT IN THE MOVIE SLEEPING BEAUTY

    Directory of Open Access Journals (Sweden)

    Muhartoyo

    2013-09-01

    Full Text Available Pragmatics is one of linguistics studies that is quite attractive to learn more about. There are many aspects of pragmatics; one of them is dealing with speech acts. Speech acts consist of many categories; one of them is directive speech act. This study aims to identify the directive speech act performed in Sleeping Beauty movie. Likewise, it will find out how often the directive speech act performed and which type of directive speech act that are most frequently used in the movie. This study used qualitative method in which data collection is done by watching the movie, analyzing the body movement and the dialogues of each character, reading the script and library research. A total of 139 directive speech acts were successfully identified. The result of analysis showed that the directive speech act of ordering is the most frequently used in the movie (21,6%. The least frequently used directive speech act is inviting directive speech act (0,7%. The study also revealed the importance of directive speech act in keeping the flow of storyline of the movie. This study is expected to give some useful insights in understanding what directive speech acts is.

  4. The Pleasure Evoked by Sad Music Is Mediated by Feelings of Being Moved

    Science.gov (United States)

    Vuoskoski, Jonna K.; Eerola, Tuomas

    2017-01-01

    Why do we enjoy listening to music that makes us sad? This question has puzzled music psychologists for decades, but the paradox of “pleasurable sadness” remains to be solved. Recent findings from a study investigating the enjoyment of sad films suggest that the positive relationship between felt sadness and enjoyment might be explained by feelings of being moved (Hanich et al., 2014). The aim of the present study was to investigate whether feelings of being moved also mediated the enjoyment of sad music. In Experiment 1, 308 participants listened to five sad music excerpts and rated their liking and felt emotions. A multilevel mediation analysis revealed that the initial positive relationship between liking and felt sadness (r = 0.22) was fully mediated by feelings of being moved. Experiment 2 explored the interconnections of perceived sadness, beauty, and movingness in 27 short music excerpts that represented independently varying levels of sadness and beauty. Two multilevel mediation analyses were carried out to test competing hypotheses: (A) that movingness mediates the effect of perceived sadness on liking, or (B) that perceived beauty mediates the effect of sadness on liking. Stronger support was obtained for Hypothesis A. Our findings suggest that – similarly to the enjoyment of sad films – the aesthetic appreciation of sad music is mediated by being moved. We argue that felt sadness may contribute to the enjoyment of sad music by intensifying feelings of being moved. PMID:28377740

  5. Black Hair is Beautiful An On-the-spot Report of 1994 XVⅢ Asian Hairstyling & Make-up Competition

    Institute of Scientific and Technical Information of China (English)

    1994-01-01

    From June 7-10 hair and beauty specialists from 20 countries in Asia gathered in Beijing to take part in the 1994 ⅩⅧ Asian Hairstyling and Make-up Competition. This was the first time the event was held in China. At the same time an international cosmetic, hair and skin care products oriental beauty exposition also was taking place. Throughout history men and women have paid attention to physical beauty, both in the West and the East, in

  6. RNA sequencing of Sleeping Beauty transposon-induced tumors detects transposon-RNA fusions in forward genetic cancer screens

    Science.gov (United States)

    Temiz, Nuri A.; Moriarity, Branden S.; Wolf, Natalie K.; Riordan, Jesse D.; Dupuy, Adam J.; Largaespada, David A.; Sarver, Aaron L.

    2016-01-01

    Forward genetic screens using Sleeping Beauty (SB)-mobilized T2/Onc transposons have been used to identify common insertion sites (CISs) associated with tumor formation. Recurrent sites of transposon insertion are commonly identified using ligation-mediated PCR (LM-PCR). Here, we use RNA sequencing (RNA-seq) data to directly identify transcriptional events mediated by T2/Onc. Surprisingly, the majority (∼80%) of LM-PCR identified junction fragments do not lead to observable changes in RNA transcripts. However, in CIS regions, direct transcriptional effects of transposon insertions are observed. We developed an automated method to systematically identify T2/Onc-genome RNA fusion sequences in RNA-seq data. RNA fusion-based CISs were identified corresponding to both DNA-based CISs (Cdkn2a, Mycl1, Nf2, Pten, Sema6d, and Rere) and additional regions strongly associated with cancer that were not observed by LM-PCR (Myc, Akt1, Pth, Csf1r, Fgfr2, Wisp1, Map3k5, and Map4k3). In addition to calculating recurrent CISs, we also present complementary methods to identify potential driver events via determination of strongly supported fusions and fusions with large transcript level changes in the absence of multitumor recurrence. These methods independently identify CIS regions and also point to cancer-associated genes like Braf. We anticipate RNA-seq analyses of tumors from forward genetic screens will become an efficient tool to identify causal events. PMID:26553456

  7. RNA sequencing of Sleeping Beauty transposon-induced tumors detects transposon-RNA fusions in forward genetic cancer screens.

    Science.gov (United States)

    Temiz, Nuri A; Moriarity, Branden S; Wolf, Natalie K; Riordan, Jesse D; Dupuy, Adam J; Largaespada, David A; Sarver, Aaron L

    2016-01-01

    Forward genetic screens using Sleeping Beauty (SB)-mobilized T2/Onc transposons have been used to identify common insertion sites (CISs) associated with tumor formation. Recurrent sites of transposon insertion are commonly identified using ligation-mediated PCR (LM-PCR). Here, we use RNA sequencing (RNA-seq) data to directly identify transcriptional events mediated by T2/Onc. Surprisingly, the majority (∼80%) of LM-PCR identified junction fragments do not lead to observable changes in RNA transcripts. However, in CIS regions, direct transcriptional effects of transposon insertions are observed. We developed an automated method to systematically identify T2/Onc-genome RNA fusion sequences in RNA-seq data. RNA fusion-based CISs were identified corresponding to both DNA-based CISs (Cdkn2a, Mycl1, Nf2, Pten, Sema6d, and Rere) and additional regions strongly associated with cancer that were not observed by LM-PCR (Myc, Akt1, Pth, Csf1r, Fgfr2, Wisp1, Map3k5, and Map4k3). In addition to calculating recurrent CISs, we also present complementary methods to identify potential driver events via determination of strongly supported fusions and fusions with large transcript level changes in the absence of multitumor recurrence. These methods independently identify CIS regions and also point to cancer-associated genes like Braf. We anticipate RNA-seq analyses of tumors from forward genetic screens will become an efficient tool to identify causal events.

  8. "That's Not Just Beautiful-That's Incredibly Beautiful!" : The Adverse Impact of Inflated Praise on Children With Low Self-Esteem

    NARCIS (Netherlands)

    Brummelman, Eddie; Thomaes, Sander; Orobio de Castro, Bram; Overbeek, Geertjan; Bushman, Brad J.

    2014-01-01

    In current Western society, children are often lavished with inflated praise (e.g., "You made an incredibly beautiful drawing!"). Inflated praise is often given in an attempt to raise children's self-esteem. An experiment (Study 1) and naturalistic study (Study 2) found that adults are especially in

  9. Dormitory of Physical and Engineering Sciences: Sleeping Beauties May Be Sleeping Innovations.

    Directory of Open Access Journals (Sweden)

    Anthony F J van Raan

    Full Text Available A 'Sleeping Beauty in Science' is a publication that goes unnoticed ('sleeps' for a long time and then, almost suddenly, attracts a lot of attention ('is awakened by a prince'. The aim of this paper is to present a general methodology to investigate (1 important properties of Sleeping Beauties such as the time-dependent distribution, author characteristics, journals and fields, and (2 the cognitive environment of Sleeping Beauties. We are particularly interested to find out to what extent Sleeping Beauties are application-oriented and thus are potential Sleeping Innovations. In this study we focus primarily on physics (including materials science and astrophysics and present first results for chemistry and for engineering & computer science. We find that more than half of the SBs are application-oriented. To study the cognitive environments of Sleeping Beauties we develop a new approach in which the cognitive environment of the SBs is analyzed, based on the mapping of Sleeping Beauties using their citation links and conceptual relations, particularly co-citation mapping. In this way we investigate the research themes in which the SBs are 'used' and possible causes of why the premature work in the SBs becomes topical, i.e., the trigger of the awakening of the SBs. This approach is tested with a blue skies SB and an application-oriented SB. We think that the mapping procedures discussed in this paper are not only important for bibliometric analyses. They also provide researchers with useful, interactive tools to discover both relevant older work as well as new developments, for instance in themes related to Sleeping Beauties that are also Sleeping Innovations.

  10. Dormitory of Physical and Engineering Sciences: Sleeping Beauties May Be Sleeping Innovations.

    Science.gov (United States)

    van Raan, Anthony F J

    2015-01-01

    A 'Sleeping Beauty in Science' is a publication that goes unnoticed ('sleeps') for a long time and then, almost suddenly, attracts a lot of attention ('is awakened by a prince'). The aim of this paper is to present a general methodology to investigate (1) important properties of Sleeping Beauties such as the time-dependent distribution, author characteristics, journals and fields, and (2) the cognitive environment of Sleeping Beauties. We are particularly interested to find out to what extent Sleeping Beauties are application-oriented and thus are potential Sleeping Innovations. In this study we focus primarily on physics (including materials science and astrophysics) and present first results for chemistry and for engineering & computer science. We find that more than half of the SBs are application-oriented. To study the cognitive environments of Sleeping Beauties we develop a new approach in which the cognitive environment of the SBs is analyzed, based on the mapping of Sleeping Beauties using their citation links and conceptual relations, particularly co-citation mapping. In this way we investigate the research themes in which the SBs are 'used' and possible causes of why the premature work in the SBs becomes topical, i.e., the trigger of the awakening of the SBs. This approach is tested with a blue skies SB and an application-oriented SB. We think that the mapping procedures discussed in this paper are not only important for bibliometric analyses. They also provide researchers with useful, interactive tools to discover both relevant older work as well as new developments, for instance in themes related to Sleeping Beauties that are also Sleeping Innovations.

  11. The biopower of beauty: humanitarian imperialisms and global feminisms in an age of terror.

    Science.gov (United States)

    Nguyen, Mimi Thi

    2011-01-01

    As part of a feminist commitment to collaboration, this article, which appears as a companion essay to Minh-Ha T. Pham's "The Right to Fashion in the Age of Terror," offers a point of departure for thinking about fashion and beauty as processes that produce subjects recruited to, and aligned with, the national interests of the United States in the war on terror. The Muslim woman in the veil and her imagined opposite, the fashionably modern and implicitly Western woman, become convenient metaphors for articulating geopolitical contests of power as human rights concerns, as rescue missions, as beautifying mandates. This essay examines newer iterations of this opposition, after September 11, 2001, in order to demonstrate the critical resonance of a biopolitics of fashion and beauty. After the events of September 11, 2001, George W. Bush's administration launched a military and public relations campaign to promote U.S. national interests using the language of feminism and human rights. While these discourses in the United States helped to reinvigorate a declining economy, and specifically a flagging fashion industry (as Pham addresses in her companion essay), feminism abroad was deployed to very different ends. This article considers the establishment of the Kabul Beauty School by the nongovernmental organization Beauty without Borders, sponsored in large part by the U.S. fashion and beauty industries. Examining troubling histories of beauty's relation to morality, humanity, and security, as well as to neoliberal discourses of self-governance, the author teases out the biopower and biopolitics of beauty, enacted here through programs of empowerment that are inseparable from the geopolitical aims of the U.S. deployment in Afghanistan.

  12. Meganuclease and transposon mediated transgenesis in medaka.

    Science.gov (United States)

    Grabher, Clemens; Wittbrodt, Joachim

    2007-01-01

    From among a plethora of various gene delivery methods, the researcher must choose the right one according to availability for a given species and the precise application the transgenic animal is intended for. Here we review the progress in meganuclease and Sleeping Beauty transposon mediated transgenesis over recent years with a focus on medaka and zebrafish. We present a side-by-side comparison of these two approaches based on their biologic properties and provide interesting perspectives for future experiments and applications, which are different for the two techniques because of their distinct modes of action.

  13. Probing flavor and CP in decays of beauty and charm

    Energy Technology Data Exchange (ETDEWEB)

    Schacht, Stefan

    2013-07-10

    In order to probe for new physics beyond the Standard Model of particle physics, we explore decays of beauty and charm mesons. In the b sector we find ourselves in the realm of precision physics so that we can improve significantly the bounds on supersymmetric flavor violation from new theoretical and experimental progress in anti B → anti K{sup (*)}l{sup +}l{sup -}. From these bounds we derive several phenomenological implications, as bounds on Radiative Flavor Violation models that are partly even sharper than the ones from Kaon physics. In order to improve the bounds on new physics models from anti B → anti K{sup (*)}l{sup +}l{sup -} even more in the future, we extract subsequently anti B → anti K{sup *} form factor ratios from data at high invariant lepton pair masses. These are the current bottleneck for the advancement in precision. In the charm sector unexpectedly large CP violation was measured recently. Currently, the experimental situation is unsettled. We work here on the main problem that one cannot reliably calculate the hadronic part from first principles, i.e., cannot exclude possible enhancements from this source. We perform for the first time a comprehensive SU(3){sub F} analysis of D → P{sub 8}P{sub 8} decays including linear breaking in full generality. We find the SU(3){sub F} expansion to be indeed working. Furthermore, the fit shows a large triplet matrix element enhancement that cannot be excluded for sure without having a dynamical theory at hand. We show as a proof of principle that with significantly improved data we could disentangle the triplet model including the Standard Model from other new physics models. Using reasonable theoretical input from QCD factorization we can eliminate some of the many degrees of freedom of the pure SU(3){sub F} analysis. This can sharpen partially the correlation between D-decay CP asymmetries and branching ratios.

  14. Leg length, proportion, health and beauty: a review.

    Science.gov (United States)

    Bogin, Barry; Varela-Silva, Maria Inês

    2009-12-01

    Decomposing stature into its major components is proving to be a useful strategy to assess the antecedents of disease, morbidity and death in adulthood. Human leg length (foot + tibia + femur), sitting height (trunk length + head length) and their proportions (for example the relative leg length in proportion to stature, and the sitting height ratio [sitting height/stature x 100], among others) are used as epidemiological markers of risk for overweight (fatness), coronary heart disease, diabetes and certain cancers. There is also wide support for the use of relative leg length as an indicator of the quality of the environment for growth during infancy, childhood and the juvenile years of development. Human beings follow a cephalo-caudal gradient of growth, the pattern of growth common to all mammals. A special feature of the human pattern is that between birth and puberty the legs grow relatively faster than other post-cranial body segments. For groups of children and youth, short stature due to relatively short legs (i.e. a high sitting height ratio) is generally a marker of an adverse environment. The development of human body proportions is the product of environmental x genomic interactions, although few if any specific genes are known. The short stature homeobox-containing gene (SHOX) is the first genomic region that may be relevant to human body proportions. For example, one of the SHOX related disorders is Turner syndrome. However, in most cases research has been showing that environment is a more powerful force to shape leg length and body proportions than genes. Leg length and proportion are important in the perception of human beauty, which is often considered a sign of health and fertility. There are a variety of cosmetic, fashion, and surgical interventions to enhance perceived or actual leg length.

  15. Can we measure beauty? Computational evaluation of coral reef aesthetics

    Directory of Open Access Journals (Sweden)

    Andreas F. Haas

    2015-11-01

    Full Text Available The natural beauty of coral reefs attracts millions of tourists worldwide resulting in substantial revenues for the adjoining economies. Although their visual appearance is a pivotal factor attracting humans to coral reefs current monitoring protocols exclusively target biogeochemical parameters, neglecting changes in their aesthetic appearance. Here we introduce a standardized computational approach to assess coral reef environments based on 109 visual features designed to evaluate the aesthetic appearance of art. The main feature groups include color intensity and diversity of the image, relative size, color, and distribution of discernable objects within the image, and texture. Specific coral reef aesthetic values combining all 109 features were calibrated against an established biogeochemical assessment (NCEAS using machine learning algorithms. These values were generated for ∼2,100 random photographic images collected from 9 coral reef locations exposed to varying levels of anthropogenic influence across 2 ocean systems. Aesthetic values proved accurate predictors of the NCEAS scores (root mean square error < 5 for N ≥ 3 and significantly correlated to microbial abundance at each site. This shows that mathematical approaches designed to assess the aesthetic appearance of photographic images can be used as an inexpensive monitoring tool for coral reef ecosystems. It further suggests that human perception of aesthetics is not purely subjective but influenced by inherent reactions towards measurable visual cues. By quantifying aesthetic features of coral reef systems this method provides a cost efficient monitoring tool that targets one of the most important socioeconomic values of coral reefs directly tied to revenue for its local population.

  16. Letter of Intent for a Tevatron Collider Beauty Factory

    Energy Technology Data Exchange (ETDEWEB)

    Volk, J.T.; Yager, P.M.; Edelstein, R.; /Carnegie Mellon U.; Christian, D.; /Fermilab; Lundberg, B.; Reay, N.W.; Reibel, K.; Sidwell, R.A.; Stanton, N.; /Ohio State U.; Kalbfleisch, G.R.; Skubic, P.; /Oklahoma U.

    1987-01-01

    A hadron collider beauty production experiment which will increase our knowledge of mixing, rare decay modes and even of CP violation could be performed using a new type of detector at the upgraded Fermilab Tevatron. In order to progress from the hundreds of thousands of B{bar B} events which can be tagged per year at a luminosity of several times 10{sup 29}/cm{sup 2}-sec to an ultimate yield of tens of millions at a luminosity of several times 10{sup 31}/cm{sup 2}-sec, they also must embark on a learning curve which will take many years and will require development both of hardware and software before achieving a final system. A new high-luminosity intersection region would have to be included as part of the presently-planned Tevatron Collider upgrade. Designing and constructing an initial system will take four years. Thus, in the light of the positive decision on the SSC, a start must be made soon if Fermilab is ever to play a strong role in this exciting area of physics. Designing even the initial system will require several man-years of effort by a dedicated group of people, together with concurrent work in prototyping and testing. They therefore ask that the Physics Advisory Committee give us their opinion of the priority such a project should be given at Fermilab, within the context that eventually it will require a devoted interaction region which accesses the full achieved luminosity of the machine. Initially, they discuss physics accessible as the B{bar B} yield increases. Subsequently, they outline a detector which can be staged, increasing its power (and cost) as we progress along our learning curve. Finally, costs and time schedules are estimated for the initial version of this detector and possible locations are discussed.

  17. Trigger selection software for beauty physics in ATLAS

    Energy Technology Data Exchange (ETDEWEB)

    Emeliyanov, D; Baines, J; Kirk, J [Rutherford Appleton Laboratory, Harwell Science and Innovation Campus, Didcot (United Kingdom); Panikashvili, N; Tarem, S [Department of Physics, Technion, Haifa (Israel); Parodi, F; Schiavi, C [Dipartimento di Fisica dell' Universita di Genova e I.N.F.N., Genova (Italy); Sivoklokov, S [Moscow State University, Moscow (Russian Federation); Watson, A [School of Physics and Astronomy, University of Birmingham, Birmingham (United Kingdom)], E-mail: Dmitry.Emeliyanov@cern.ch

    2008-07-01

    The unprecedented rate of beauty production at the LHC will yield high statistics for measurements such as CP violation and B{sub a} oscillations and will provide the opportunity to search for and study very rare decays, such as B {yields} {mu}{mu}. The trigger is a vital component for this work and must select events containing the channels of interest from a huge background in order to reduce the 40 MHz bunch crossing rate down to 100-200 Hz for recording, of which only a part will be assigned to B-physics. Requiring a single or di-muon trigger provides the first stage of the B-trigger selection. Track reconstruction is then performed in the Inner Detector, either using the full detector, at initial luminosity, or within Regions of Interest identified by the first level trigger at higher luminosities. Based on invariant mass, combinations of tracks are selected as likely decay products of the channel of interest and secondary vertex fits are performed. Events are selected based on properties such as fit quality and invariant mass. We present fast vertex reconstruction algorithms suitable for use in the second level trigger and event filter (level three). We discuss the selection software and the flexible trigger strategies that will enable ATLAS to pursue a B-physics programme from the first running at a luminosity of about 10{sup 31}cm{sup -2}s-{sup 1} through to the design luminosity running at 10{sup 34}cm{sup -2}s-{sup 1}.

  18. Intercultural Mediation

    OpenAIRE

    Dragos Marian Radulescu; Denisa Mitrut

    2012-01-01

    The Intercultural Mediator facilitates exchanges between people of different socio-cultural backgrounds and acts as a bridge between immigrants and national and local associations, health organizations, services and offices in order to foster integration of every single individual. As the use mediation increases, mediators are more likely to be involved in cross-cultural mediation, but only the best mediators have the opportunity to mediate cross border business disputes or international poli...

  19. Quest for BeautyTimes and Methods ChangBut the Goal is the Same

    Institute of Scientific and Technical Information of China (English)

    JANE SHAW

    1994-01-01

    THE Chinese traditionally have held a contradictory attitude about female beauty. In the Book of Songs women’s good looks are praised: "How pretty she looks when she smiles at the right moment, how inviting her beautiful eyes are." These are lines which remain famous because the ideal they convey is still popular in modern China. Even the Ballad of Mu Lan, written during the Northern Dynasty, describes how Mu Lan made up in front of the mirror after she returned from active service for her father. Female beauty and women’s jewelry was so appreciated in the past that fendai (fen is cosmetic powder and dai is a black pigment used by women in ancient times to darken their eyebrows) and qunchai (qun is a skirt and chai a hairpin) became synonymous with women. Yet at the same time, female beauty was considered mysterious, a taboo whose temptation was very much feared by men. Historically, great beauties were placed in two

  20. Sleeping Beauties Cited in Patents: Is there also a Dormitory of Inventions?

    CERN Document Server

    van Raan, Anthony F J

    2016-01-01

    A Sleeping Beauty in Science is a publication that goes unnoticed (sleeps) for a long time and then, almost suddenly, attracts a lot of attention (is awakened by a prince). In our foregoing study we found that roughly half of the Sleeping Beauties are application-oriented and thus are potential Sleeping Innovations. In this paper we investigate a new topic: Sleeping Beauties that are cited in patents. In this way we explore the existence of a dormitory of inventions. We find that patent citation may occur before or after the awakening and that the depth of the sleep, i.e., citation rate during the sleeping period, is no predictor for later scientific or technological impact of the Sleeping Beauty. Inventor-author self-citations occur only in a small minority of the Sleeping Beauties that are cited in patents, but other types of inventor-author links occur more frequently. We analyze whether they deal with new topics by measuring the time-dependent evolution in the entire scientific literature of the number of...