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Sample records for beauty mediates therapeutic

  1. Sleeping Beauty-Mediated Drug Resistance Gene Transfer in Human Hematopoietic Progenitor Cells.

    Science.gov (United States)

    Hyland, Kendra A; Olson, Erik R; McIvor, R Scott

    2015-10-01

    The Sleeping Beauty (SB) transposon system can insert sequences into mammalian chromosomes, supporting long-term expression of both reporter and therapeutic genes. Hematopoietic progenitor cells (HPCs) are an ideal therapeutic gene transfer target as they are used in therapy for a variety of hematologic and metabolic conditions. As successful SB-mediated gene transfer into human CD34(+) HPCs has been reported by several laboratories, we sought to extend these studies to the introduction of a therapeutic gene conferring resistance to methotrexate (MTX), potentially providing a chemoprotective effect after engraftment. SB-mediated transposition of hematopoietic progenitors, using a transposon encoding an L22Y variant dihydrofolate reductase fused to green fluorescent protein, conferred resistance to methotrexate and dipyridamole, a nucleoside transport inhibitor that tightens MTX selection conditions, as assessed by in vitro hematopoietic colony formation. Transposition of individual transgenes was confirmed by sequence analysis of transposon-chromosome junctions recovered by linear amplification-mediated PCR. These studies demonstrate the potential of SB-mediated transposition of HPCs for expression of drug resistance genes for selective and chemoprotective applications. PMID:26176276

  2. Comparison of lentiviral and sleeping beauty mediated αβ T cell receptor gene transfer.

    Directory of Open Access Journals (Sweden)

    Anne-Christine Field

    Full Text Available Transfer of tumour antigen-specific receptors to T cells requires efficient delivery and integration of transgenes, and currently most clinical studies are using gamma retroviral or lentiviral systems. Whilst important proof-of-principle data has been generated for both chimeric antigen receptors and αβ T cell receptors, the current platforms are costly, time-consuming and relatively inflexible. Alternative, more cost-effective, Sleeping Beauty transposon-based plasmid systems could offer a pathway to accelerated clinical testing of a more diverse repertoire of recombinant high affinity T cell receptors. Nucleofection of hyperactive SB100X transposase-mediated stable transposition of an optimised murine-human chimeric T cell receptor specific for Wilm's tumour antigen from a Sleeping Beauty transposon plasmid. Whilst transfer efficiency was lower than that mediated by lentiviral transduction, cells could be readily enriched and expanded, and mediated effective target cells lysis in vitro and in vivo. Integration sites of transposed TCR genes in primary T cells were almost randomly distributed, contrasting the predilection of lentiviral vectors for transcriptionally active sites. The results support exploitation of the Sleeping Beauty plasmid based system as a flexible and adaptable platform for accelerated, early-phase assessment of T cell receptor gene therapies.

  3. RNA interference is responsible for reduction of transgene expression after Sleeping Beauty transposase mediated somatic integration.

    Directory of Open Access Journals (Sweden)

    Christina Rauschhuber

    Full Text Available BACKGROUND: Integrating non-viral vectors based on transposable elements are widely used for genetically engineering mammalian cells in functional genomics and therapeutic gene transfer. For the Sleeping Beauty (SB transposase system it was demonstrated that convergent transcription driven by the SB transposase inverted repeats (IRs in eukaryotic cells occurs after somatic integration. This could lead to formation of double-stranded RNAs potentially presenting targets for the RNA interference (RNAi machinery and subsequently resulting into silencing of the transgene. Therefore, we aimed at investigating transgene expression upon transposition under RNA interference knockdown conditions. PRINCIPAL FINDINGS: To establish RNAi knockdown cell lines we took advantage of the P19 protein, which is derived from the tomato bushy stunt virus. P19 binds and inhibits 21 nucleotides long, small-interfering RNAs and was shown to sufficiently suppress RNAi. We found that transgene expression upon SB mediated transposition was enhanced, resulting into a 3.2-fold increased amount of colony forming units (CFU after transposition. In contrast, if the transgene cassette is insulated from the influence of chromosomal position effects by the chicken-derived cHS4 insulating sequences or when applying the Forg Prince transposon system, that displays only negligible transcriptional activity, similar numbers of CFUs were obtained. CONCLUSION: In summary, we provide evidence for the first time that after somatic integration transposon derived transgene expression is regulated by the endogenous RNAi machinery. In the future this finding will help to further improve the molecular design of the SB transposase vector system.

  4. Epigenetics and therapeutic targets mediating neuroprotection.

    Science.gov (United States)

    Qureshi, Irfan A; Mehler, Mark F

    2015-12-01

    The rapidly evolving science of epigenetics is transforming our understanding of the nervous system in health and disease and holds great promise for the development of novel diagnostic and therapeutic approaches targeting neurological diseases. Increasing evidence suggests that epigenetic factors and mechanisms serve as important mediators of the pathogenic processes that lead to irrevocable neural injury and of countervailing homeostatic and regenerative responses. Epigenetics is, therefore, of considerable translational significance to the field of neuroprotection. In this brief review, we provide an overview of epigenetic mechanisms and highlight the emerging roles played by epigenetic processes in neural cell dysfunction and death and in resultant neuroprotective responses. This article is part of a Special Issue entitled SI: Neuroprotection.

  5. [Video games, a therapeutic mediator for teens].

    Science.gov (United States)

    Nickler, Christophe

    2015-10-01

    Teenagers love video games and other multimedia tools. Sometimes they love them too much, leading to addictive use. A child psychiatry team in Nancy has developed a therapeutic multimedia workshop to contribute to treating teens.

  6. [Video games, a therapeutic mediator for teens].

    Science.gov (United States)

    Nickler, Christophe

    2015-10-01

    Teenagers love video games and other multimedia tools. Sometimes they love them too much, leading to addictive use. A child psychiatry team in Nancy has developed a therapeutic multimedia workshop to contribute to treating teens. PMID:26455625

  7. The Slaying of a Beautiful Hypothesis: The Efficacy of Counseling and the Therapeutic Process

    Science.gov (United States)

    Hauser, Mike; Hays, Danica G.

    2010-01-01

    Although the efficacy of counseling has been empirically linked to the therapeutic process, the emphasis in much of the literature remains on technique use. This article discusses 3 components of therapeutic efficacy (i.e., common factors, working alliance, and counselor attributes) and provides implications for counselors and counselor training.…

  8. [The drawing as a therapeutic mediation tool for gifted children].

    Science.gov (United States)

    Leverrier, Jenny; Titia Rizzi, Alice; Mouchenik, Yoram

    2016-01-01

    Intellectual precocity arouses a number of preconceived ideas. While it labels the children concerned as gifted and destined to become exceptional adults, it confines and prescribes and does not guarantee academic success. Based on the hypothesis of the suffering of these children, mediation through drawing is a valuable therapeutic tool. PMID:27015700

  9. Derivation and characterization of sleeping beauty transposon-mediated porcine induced pluripotent stem cells

    DEFF Research Database (Denmark)

    Kues, Wilfried A.; Herrmann, Doris; Barg-Kues, Brigitte;

    2013-01-01

    the nonviral Sleeping Beauty transposon system to deliver the reprogramming factors Oct4, Sox2, Klf4, and cMyc. Successful reprogramming to a pluripotent state was indicated by changes in cell morphology and reactivation of the Oct4-EGFP reporter. The transposon-reprogrammed induced pluripotent stem (i...

  10. Human neutrophil elastase: mediator and therapeutic target in atherosclerosis.

    Science.gov (United States)

    Henriksen, Peter A; Sallenave, Jean-Michel

    2008-01-01

    Human neutrophil elastase (HNE) is present within atherosclerotic plaques where it contributes to matrix degradation and weakening of the vessel wall associated with the complications of aneurysm formation and plaque rupture. It is joined by other extracellular proteases in these actions but the broad range of substrates and potency of HNE coupled with the potential for rapid increases in HNE activity associated with neutrophil degranulation in acute coronary syndromes single this disruptive protease out as therapeutic target in atherosclerotic disease. This review summarises the role of HNE in neutrophil-mediated endothelial injury and the evidence for HNE as a mediator of atherosclerotic plaque development. The therapeutic potential of HNE neutralising antiproteases, alpha-1-antitrypsin and elafin, in atherosclerosis, is discussed. PMID:18289916

  11. [Mechanism of mediators in human skin. Pharmacoanalysis and therapeutic aspects].

    Science.gov (United States)

    Stüttgen, G

    1977-06-01

    Under physiological and pathological conditions, the skin is influenced by tissue hormones (biogenic amines, kinines, prostaglandines), neuro-hormones (acetylcholine, catecholamines) and by proteins as complement. The combination of neurological stimulation with a series of self-propagating metabolic changes, shows new aspects of tissue reaction. Histamine triggers a serie of mediators as kinines and prostaglandines. Due to their influence on mediators and their effects on regulatory mechanisms the cyclic nucleotides can serve as model substances for the development of therapeutic processes for dermatological as well as for other disorders. The influence on mediator-systems by topical treatment and proven permeability of such substances is of extreme importance for the future development of local dermatological therapy.

  12. Effective Expression-Independent Gene Trapping and Mutagenesis Mediated by Sleeping Beauty Transposon

    Institute of Scientific and Technical Information of China (English)

    Guili Song; Qing Li; Yong Long; Perry B. Hackett; Zongbin Cui

    2012-01-01

    Expression-independent gene or polyadenylation [poly(A)] trapping is a powerful tool for genome-wide mutagenesis regardless of whether a targeted gene is expressed.Although a number of poly(A)-trap vectors have been developed for the capture and mutation of genes across a vertebrate genome,further efforts are needed to avoid the 3′-terminal insertion bias and the splice donor (SD)read-through,and to improve the mutagenicity.Here,we present a Sleeping Beauty (SB) transposon-based vector that can overcome these limitations through the inclusion of three functional cassettes required for gene-finding,gene-breaking and large-scale mutagenesis,respectively.The functional cassette contained a reporter/selective marker gene driven by a constitutive promoter in front of a strong SD signal and an AU-rich RNA-destabilizing element (ARE),which greatly reduced the SD read-through events,except that the internal ribosomal entry site (IRES) element was introduced in front of the SD signal to overcome the phenomenon of 3′-bias gene trapping.The breaking cassette consisting of an enhanced splicing acceptor (SA),a poly(A) signal coupled with a transcriptional terminator (TT) effectively disrupted the transcription of trapped genes.Moreover,the Hsp70 promoter from tilapia genome was employed to drive the inducible expression of SB11,which allows the conditional remobilization of a trap insert from a non-coding region.The combination of three cassettes led to effective capture and disruption of endogenous genes in HeLa cells.In addition,the Cre/LoxP system was introduced to delete the Hsp70-SB11 cassette for stabilization of trapped gene interruption and biosafety.Thus,this poly(A)-trap vector is an alternative and effective tool for identification and mutation of endogenous genes in cells and animals.

  13. Lung Regeneration: Endogenous and Exogenous Stem Cell Mediated Therapeutic Approaches

    Directory of Open Access Journals (Sweden)

    Khondoker M. Akram

    2016-01-01

    Full Text Available The tissue turnover of unperturbed adult lung is remarkably slow. However, after injury or insult, a specialised group of facultative lung progenitors become activated to replenish damaged tissue through a reparative process called regeneration. Disruption in this process results in healing by fibrosis causing aberrant lung remodelling and organ dysfunction. Post-insult failure of regeneration leads to various incurable lung diseases including chronic obstructive pulmonary disease (COPD and idiopathic pulmonary fibrosis. Therefore, identification of true endogenous lung progenitors/stem cells, and their regenerative pathway are crucial for next-generation therapeutic development. Recent studies provide exciting and novel insights into postnatal lung development and post-injury lung regeneration by native lung progenitors. Furthermore, exogenous application of bone marrow stem cells, embryonic stem cells and inducible pluripotent stem cells (iPSC show evidences of their regenerative capacity in the repair of injured and diseased lungs. With the advent of modern tissue engineering techniques, whole lung regeneration in the lab using de-cellularised tissue scaffold and stem cells is now becoming reality. In this review, we will highlight the advancement of our understanding in lung regeneration and development of stem cell mediated therapeutic strategies in combating incurable lung diseases.

  14. The medicalization of beauty

    Directory of Open Access Journals (Sweden)

    Paulo Poli Neto

    2007-01-01

    Full Text Available Concern with body image and medical interventions related to physical beauty has greatly increased in the past few years. The purpose of this study is to investigate how medicine is dealing with the theme of beauty. The 2003/2004 editions of the periodicals Aesthetic Surgery Journal and Aesthetic Plastic Surgery were analyzed, in order to investigate the rationality buttressing their discourse. Three categories were prioritized for this study: definition of aesthetic plastic surgery's study object; beauty patterns guiding interventions; and understanding popular demand for aesthetic corrections. Discourse is sustained by biomedical rationality, structured around a disease theory and a dual construction between normal and pathological, with emphasis on biology. In the articles, the beauty patterns guiding therapeutic practices are anchored in biological norms defined through several anthropometric measures, which refer to abstract concepts of beauty, harmony, proportionality and symmetry. In this discourse, there are no references to patterns or to social norms of beauty; motivation for aesthetic intervention appears to be rooted in low self-esteem related to the aging process or to some bodily nonconformity. As per the meaning of 'medicalization' adopted herein, biomedical rationality appropriates variations or anomalies of physical appearance, thus allowing the theme to be dealt with in terms of health and disease, normal and pathological.

  15. Cell mediated therapeutics for cancer treatment: Tumor homing cells as therapeutic delivery vehicles

    Science.gov (United States)

    Balivada, Sivasai

    Many cell types were known to have migratory properties towards tumors and different research groups have shown reliable results regarding cells as delivery vehicles of therapeutics for targeted cancer treatment. Present report discusses proof of concept for 1. Cell mediated delivery of Magnetic nanoparticles (MNPs) and targeted Magnetic hyperthermia (MHT) as a cancer treatment by using in vivo mouse cancer models, 2. Cells surface engineering with chimeric proteins for targeted cancer treatment by using in vitro models. 1. Tumor homing cells can carry MNPs specifically to the tumor site and tumor burden will decrease after alternating magnetic field (AMF) exposure. To test this hypothesis, first we loaded Fe/Fe3O4 bi-magnetic NPs into neural progenitor cells (NPCs), which were previously shown to migrate towards melanoma tumors. We observed that NPCs loaded with MNPs travel to subcutaneous melanoma tumors. After alternating magnetic field (AMF) exposure, the targeted delivery of MNPs by the NPCs resulted in a mild decrease in tumor size (Chapter-2). Monocytes/macrophages (Mo/Ma) are known to infiltrate tumor sites, and also have phagocytic activity which can increase their uptake of MNPs. To test Mo/Ma-mediated MHT we transplanted Mo/Ma loaded with MNPs into a mouse model of pancreatic peritoneal carcinomatosis. We observed that MNP-loaded Mo/Ma infiltrated pancreatic tumors and, after AMF treatment, significantly prolonged the lives of mice bearing disseminated intraperitoneal pancreatic tumors (Chapter-3). 2. Targeted cancer treatment could be achieved by engineering tumor homing cell surfaces with tumor proteases cleavable, cancer cell specific recombinant therapeutic proteins. To test this, Urokinase and Calpain (tumor specific proteases) cleavable; prostate cancer cell (CaP) specific (CaP1 targeting peptide); apoptosis inducible (Caspase3 V266ED3)- rCasp3V266ED3 chimeric protein was designed in silico. Hypothesized membrane anchored chimeric protein (rCasp3V

  16. Internalization of U.S. female beauty standards as a mediator of the relationship between Mexican American women's acculturation and body dissatisfaction.

    Science.gov (United States)

    Poloskov, Elizabeth; Tracey, Terence J G

    2013-09-01

    The relationships among acculturation, internalization of U.S. sociocultural standards of female beauty, and body dissatisfaction were examined in a sample of 211 Mexican American college women. Structural equation modeling was used to identify the paths among these three factors. Results demonstrated that there are two distinct types of body dissatisfaction: global evaluations and composite site-specific evaluations. The relationships between acculturation toward dominant U.S. culture and both types of body dissatisfaction were found to be fully mediated by internalization of U.S. standards of female beauty. There were no relationships between Mexican orientation and any of the study variables. The results from this study imply that it is important for therapists working with Mexican American female clients to assess the client's level of acculturation, examine the cultural (U.S. and Mexican) messages the client receives, and explore how these messages impact her body image. PMID:23809859

  17. Beautiful Politicians

    OpenAIRE

    Amy King; Andrew Leigh

    2009-01-01

    Are beautiful politicians more likely to be elected? To test this, we use evidence from Australia, a country in which voting is compulsory, and in which voters are given ‘How to Vote’ cards depicting photos of the major party candidates as they arrive to vote. Using raters chosen to be representative of the electorate, we assess the beauty of political candidates from major political parties, and then estimate the effect of beauty on voteshare for candidates in the 2004 federal election. Beau...

  18. Beautiful equations

    Science.gov (United States)

    Viljamaa, Panu; Jacobs, J. Richard; Chris; JamesHyman; Halma, Matthew; EricNolan; Coxon, Paul

    2014-07-01

    In reply to a Physics World infographic (part of which is given above) about a study showing that Euler's equation was deemed most beautiful by a group of mathematicians who had been hooked up to a functional magnetic-resonance image (fMRI) machine while viewing mathematical expressions (14 May, http://ow.ly/xHUFi).

  19. Carbon nanotubes as cancer therapeutic carriers and mediators

    Science.gov (United States)

    Son, Kuk Hui; Hong, Jeong Hee; Lee, Jin Woo

    2016-01-01

    Carbon nanotubes (CNTs) have received increasing attention in biomedical fields because of their unique structures and properties, including high aspect ratios, large surface areas, rich surface chemical functionalities, and size stability on the nanoscale. Particularly, they are attractive as carriers and mediators for cancer therapy. Through appropriate functionalization, CNTs have been used as nanocarriers for anticancer drugs including doxorubicin, camptothecin, carboplatin, cisplatin, paclitaxel, Pt(II), and Pt(IV), and genes including plasmid DNA, small-interfering RNA, oligonucleotides, and RNA/DNA aptamers. CNTs can also deliver proteins and immunotherapy components. Using combinations of light energy, they have also been applied as mediators for photothermal therapy and photodynamic therapy to directly destroy cancer cells without severely damaging normal tissue. If limitations such as a long-term cytotoxicity in the body, lack of size uniformity during the synthetic process, loading deviations for drug–CNT complexes, and release controllability at the target point are overcome, CNTs will become one of the strongest tools that are available for various other biomedical fields as well as for cancer therapy. PMID:27785021

  20. Beautiful Flowers

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    春天到了,百花盛开,我们常说“美丽的鲜花”,就是:beautiful flowers。是不是觉得这两个单词有点儿难记呢?没关系,来玩玩我们的进宫吧,它能帮助你牢牢记住这两个单词的拼法。

  1. Beautiful city

    OpenAIRE

    Gerald A. Carlino

    2009-01-01

    Proponents of the City Beautiful movement advocated for sizable public investments in monumental spaces, street beautification, and classical architecture. Today, economists and policymakers see the provision of consumer leisure amenities as a way to attract people and jobs to cities. But past studies have provided only indirect evidence of the importance of leisure amenities for urban growth and development. In this article, Jerry Carlino uses a new data set on the number of leisure tourist ...

  2. Beautiful Serbia

    OpenAIRE

    Bonin, Holger; Rinne, Ulf

    2006-01-01

    The paper studies the causal impact of participation in an active labor market program - the 'Beautiful Serbia' program providing training and temporary work in the construction sector in Serbia and Montenegro - on measures of subjective well-being approximating individual welfare. According to our estimates, the positive impact of this particular program appears much stronger judged by subjective well-being than judged by the immediate labor market effect.

  3. City Beautiful

    OpenAIRE

    Gerald A. Carlino; Saiz, Albert

    2008-01-01

    The City Beautiful movement, which in the early 20th century advocated city beautification as a way to improve the living conditions and civic virtues of the urban dweller, had languished by the Great Depression. Today, new urban economic theorists and policymakers are coming to see the provision of consumer leisure amenities as a way to attract population, especially the highly skilled and their employers. However, past studies have provided only indirect evidence of the importance of leisur...

  4. Beautiful kit

    OpenAIRE

    Mark Miodownik

    2004-01-01

    Mark Miodownik reports on laboratory machines such as scanning electron microscopes with energy dispersive X-ray analysis which is latest thing. The author finds high status of scientific instruments in science laboratory which are the aesthetics of instrument design. The astrolabs, microscopes, telescopes and armillary spheres are beautiful objects according to the author. The equipment design provides demonstration of functionality over form and declares superfluousness of aesthetics to sci...

  5. [Therapeutic mediation tools for the benefit of the child and teenager].

    Science.gov (United States)

    Rocaboy, Claudette

    2016-01-01

    Therapeutic mediation is a tool adapted to teenagers with a chronic disease such as diabetes. Psychodrama, dramatherapy and photolanguage in particular, enable them to express themselves more freely through both speech and body, thanks to the enjoyment they get from the game, the reassurance provided by the group, the structured setting and the spontaneity they allow. PMID:26776691

  6. Beautiful geometry

    CERN Document Server

    Maor, Eli

    2014-01-01

    If you've ever thought that mathematics and art don't mix, this stunning visual history of geometry will change your mind. As much a work of art as a book about mathematics, Beautiful Geometry presents more than sixty exquisite color plates illustrating a wide range of geometric patterns and theorems, accompanied by brief accounts of the fascinating history and people behind each. With artwork by Swiss artist Eugen Jost and text by acclaimed math historian Eli Maor, this unique celebration of geometry covers numerous subjects, from straightedge-and-compass constructions to intriguing configur

  7. Beauty pays but does investment in beauty?

    OpenAIRE

    Lee, Soohyung

    2015-01-01

    Being beautiful gives a person an advantage in many settings. Attractive people earn more and have an easier time getting hired. People spend large amounts of money on goods and services to enhance their beauty. Is this enhancement worth pursuing? Research suggests that the expected improvement in beauty from these goods and services is limited. Therefore, despite the large returns from having an attractive appearance, the cost-effectiveness of investment in beauty enhancement is ambiguous. F...

  8. TLR-mediated NF-kB-dependent cytokine production is differently affected by HIV therapeutics

    DEFF Research Database (Denmark)

    Melchjorsen, Jesper; Paludan, Søren Riis; Mogensen, Trine;

      Pathogen-recognizing Toll-like receptors 2 (TLR2) and TLR4 are known to recognize a number of pathogens, including E.Coli, S. Pneumonia and N. Meningococcus. We have studied whether a number of HIV therapeutics affect immediate proinflammatory cytokine responses in cell cultures. Preliminary...... results suggest an opposing effect of the drugs Tenofovir and Retrovir (AZT) on TLR-mediated production of NF-kappaB-dependent proinflammatory cytokines. We present data on the mechanisms behind the drug-mediated remodeling of innate immune activation and how the drugs effect early host...

  9. Beautiful asymmetry

    International Nuclear Information System (INIS)

    The LHCb experiment at CERN will allow researchers to study the difference between matter and antimatter with unprecedented accuracy, explains Roger Forty. Our current understanding of matter and forces at the subatomic scale, as embodied in the Standard Model of particle physics, is widely considered incomplete. Its most famous missing ingredient is the Higgs Boson, thought to endow all particles with mass, but there are strong indications that other pieces of the theoretical jigsaw puzzle are missing too. One of these concerns 'dark matter', the mysterious substance thought to make up more than a fifth of the universe. Postulated to account for gravitational effects that cannot be explained by the amount of visible matter alone, dark matter could be made up of exotic new particles that are not described by the Standard Model. Fortunately, there is a good chance that such particles - and the Higgs - will be created in the high-energy collisions between protons at the Large Hadron Collider (LHC). There are two approaches to discovering such new physics. The first is to try and observe the new particles directly by detecting their decay products, which will be the goal of the two giant 'general-purpose' LHC experiments ATLAS and CMS. The alternative approach is to make precision measurements of parameters that are predicted within the Standard Model and to look for deviations that could be due to as-yet-undetected particles. This is the goal of the LHCb (LHC beauty) experiment, which is dedicated to the precision study of particles that contain the bottom or beauty quark. (U.K.)

  10. Generation of mouse induced pluripotent stem cells from different genetic backgrounds using Sleeping beauty transposon mediated gene transfer.

    Science.gov (United States)

    Muenthaisong, Suchitra; Ujhelly, Olga; Polgar, Zsuzsanna; Varga, Eszter; Ivics, Zoltan; Pirity, Melinda K; Dinnyes, Andras

    2012-11-15

    Induced pluripotent stem (iPS) cell technology involves reprogramming somatic cells to a pluripotent state. The original technology used to produce these cells requires viral gene transduction and results in the permanent integration of exogenous genes into the genome. This can lead to the development of abnormalities in the derived iPS cells. Here, we report that non-viral transfection of a Sleeping Beauty (SB) transposon containing the coding sequences Oct3/4 (Pouf1), Sox-2, Klf-4 and c-Myc (OSKM) linked with 2A peptides, can reprogram mouse fibroblasts. We have established reprogrammed mouse cell lines from three different genetic backgrounds: (1) ICR-outbred, (2) C57BL/6-inbred and (3) F1-hybrid (C57BL/6 x DBA/2J), with parallel robust expression of all exogenous (Oct3/4, Sox-2, Klf-4, and c-Myc) and endogenous (e.g. Oct3/4 and Nanog) pluripotency genes. The iPS cell lines exhibited characteristics typical for undifferentiated embryonic stem (ES) cell lines: ES cell-like morphology, alkaline phosphatase (ALP) positivity and gene expression pattern (shown by reverse transcription PCR, and immunofluorescence of ES cell markers-e.g. Oct3/4, SSEA1, Nanog). Furthermore, cells were able to form embryoid bodies (EBs), to beat rhythmically, and express cardiac (assayed by immunofluorescence, e.g. cardiac Troponin T, desmin) and neuronal (assayed by immunofluorescence e.g. nestin, Tuj1) markers. The in vitro differentiation potential was found to be the highest in the ICR-derived iPS lines (ICR-iPS). Interestingly, the ICR-iPS lines had even higher differentiation potential than the ICR-ES cell lines: the rate of EBs forming rhythmically beating cardiomyocytes was 4% in ICR-ES and 79% in ICR-iPS cells, respectively. In vivo, the ICR and F1 hybrid iPS cells formed chimeras and one of the iPS cells from the F1 hybrid background transmitted to the germline. Our results suggest that iPS technology may be useful for generating pluripotent stem cells from genetic backgrounds

  11. Lentivirus-mediated gene transfer to the central nervous system: therapeutic and research applications.

    Science.gov (United States)

    Wong, Liang-Fong; Goodhead, Lucy; Prat, Christine; Mitrophanous, Kyriacos A; Kingsman, Susan M; Mazarakis, Nicholas D

    2006-01-01

    The management of disorders of the nervous system remains a medical challenge. The key goals are to understand disease mechanisms, to validate therapeutic targets, and to develop new therapeutic strategies. Viral vector-mediated gene transfer can meet these goals and vectors based on lentiviruses have particularly useful features. Lentiviral vectors can deliver 8 kb of sequence, they mediate gene transfer into any neuronal cell type, expression and therapy are sustained, and normal cellular functions in vitro and in vivo are not compromised. After delivery into the nervous system they induce no significant immune responses, there are no unwanted side effects of the vectors per se to date, and manufacturing and safety testing for clinical applications are well advanced. There are now numerous examples of effective long-term treatment of animal models of neurological disorders, such as Parkinson's disease, Alzheimer's disease, Huntington's disease, motor neuron diseases, lysosomal storage diseases, and spinal injury, using a range of therapeutic genes expressed in lentiviral vectors. Significant issues remain in some areas of neural gene therapy including defining the optimum therapeutic gene(s), increasing the specificity of delivery, regulating expression of potentially toxic genes, and designing clinically relevant strategies. We discuss the applications of lentiviral vectors in therapy and research and highlight the essential features that will ensure their translation to the clinic in the near future. PMID:16409120

  12. Hypoxia-Inducible Factors: Mediators of Cancer Progression; Prognostic and Therapeutic Targets in Soft Tissue Sarcomas

    Energy Technology Data Exchange (ETDEWEB)

    Sadri, Navid; Zhang, Paul J., E-mail: pjz@mail.med.upenn.edu [Anatomic Pathology, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, 3400 Spruce Street, 6th Floor Founders Building, Philadelphia, PA 19104 (United States)

    2013-04-02

    Soft-tissue sarcomas remain aggressive tumors that result in death in greater than a third of patients due to either loco-regional recurrence or distant metastasis. Surgical resection remains the main choice of treatment for soft tissue sarcomas with pre- and/or post-operational radiation and neoadjuvant chemotherapy employed in more advanced stage disease. However, in recent decades, there has been little progress in the average five-year survival for the majority of patients with high-grade soft tissue sarcomas, highlighting the need for improved targeted therapeutic agents. Clinical and preclinical studies demonstrate that tumor hypoxia and up-regulation of hypoxia-inducible factors (HIFs) is associated with decreased survival, increased metastasis, and resistance to therapy in soft tissue sarcomas. HIF-mediated gene expression regulates many critical aspects of tumor biology, including cell survival, metabolic programming, angiogenesis, metastasis, and therapy resistance. In this review, we discuss HIFs and HIF-mediated genes as potential prognostic markers and therapeutic targets in sarcomas. Many pharmacological agents targeting hypoxia-related pathways are in development that may hold therapeutic potential for treating both primary and metastatic sarcomas that demonstrate increased HIF expression.

  13. Phytochemical-mediated Protein Expression Profiling and the Potential Applications in Therapeutic Drug Target Identifications.

    Science.gov (United States)

    Wong, Fai-Chu; Tan, Siok-Thing; Chai, Tsun-Thai

    2016-07-29

    Many phytochemicals derived from edible medicinal plants have been investigated intensively for their various bioactivities. However, the detailed mechanism and their corresponding molecular targets frequently remain elusive. In this review, we present a summary of the research works done on phytochemical-mediated molecular targets, identified via proteomic approach. Concurrently, we also highlighted some pharmaceutical drugs which could be traced back to their origins in phytochemicals. For ease of presentation, these identified protein targets were categorized into two important healthcare-related fields, namely anti-bacterial and anti-cancer research. Through this review, we hope to highlight the usefulness of comparative proteomic as a powerful tool in phytochemical-mediated protein target identifications. Likewise, we wish to inspire further investigations on some of these protein targets identified over the last few years. With contributions from all researchers, the accumulative efforts could eventually lead to the discovery of some target-specific, low-toxicity therapeutic agents. PMID:26193174

  14. The Real Beauty

    Institute of Scientific and Technical Information of China (English)

    胡晓媛

    2015-01-01

    it is well-known that all men search for beauty.Although the definition of beauty changes as time goes by,people still spare no efforts to pursue beauty in their lives.Meanwhile,most people try every means to make their body images better.With more people increasingly being eager for beauty in various ways,it is high time that we should think deeply about the concept of real beauty.In this paper,an attempt has been made to shed light on the real beauty.It is not completely physical appearance or slim figure,but a healthy body and peaceful mind as well as admirable courage.Above all,whether people can realize the nature of real beauty is certainly worthwhile for us to ponder.

  15. The Real Beauty

    Institute of Scientific and Technical Information of China (English)

    胡晓媛

    2015-01-01

    it is well-known that all men search for beauty. Although the definition of beauty changes as time goes by,people still spare no efforts to pursue beauty in their lives. Meanwhile,most people try every means to make their body images better.With more people increasingly being eager for beauty in various ways,it is high time that we should think deeply about the concept of real beauty.Inthis paper,an attempt has been made to shed light on the real beauty.It is not completely physical appearance or slim figure,but a healthy body and peaceful mind as well as admirable courage.Above all,whether people can realize the nature of real beauty is certainly worthwhile for us to ponder.

  16. Therapeutic Blockade of Immune Complex-Mediated Glomerulonephritis by Highly Selective Inhibition of Bruton's Tyrosine Kinase.

    Science.gov (United States)

    Chalmers, Samantha A; Doerner, Jessica; Bosanac, Todd; Khalil, Sara; Smith, Dustin; Harcken, Christian; Dimock, Janice; Der, Evan; Herlitz, Leal; Webb, Deborah; Seccareccia, Elise; Feng, Di; Fine, Jay S; Ramanujam, Meera; Klein, Elliott; Putterman, Chaim

    2016-01-01

    Lupus nephritis (LN) is a potentially dangerous end organ pathology that affects upwards of 60% of lupus patients. Bruton's tyrosine kinase (BTK) is important for B cell development, Fc receptor signaling, and macrophage polarization. In this study, we investigated the effects of a novel, highly selective and potent BTK inhibitor, BI-BTK-1, in an inducible model of LN in which mice receive nephrotoxic serum (NTS) containing anti-glomerular antibodies. Mice were treated once daily with vehicle alone or BI-BTK-1, either prophylactically or therapeutically. When compared with control treated mice, NTS-challenged mice treated prophylactically with BI-BTK-1 exhibited significantly attenuated kidney disease, which was dose dependent. BI-BTK-1 treatment resulted in decreased infiltrating IBA-1+ cells, as well as C3 deposition within the kidney. RT-PCR on whole kidney RNA and serum profiling indicated that BTK inhibition significantly decreased levels of LN-relevant inflammatory cytokines and chemokines. Renal RNA expression profiling by RNA-seq revealed that BI-BTK-1 dramatically modulated pathways related to inflammation and glomerular injury. Importantly, when administered therapeutically, BI-BTK-1 reversed established proteinuria and improved renal histopathology. Our results highlight the important role for BTK in the pathogenesis of immune complex-mediated nephritis, and BTK inhibition as a promising therapeutic target for LN. PMID:27192942

  17. Open Beauty Production

    OpenAIRE

    Sefkow, Felix

    2001-01-01

    We review measurements of open beauty production at HERA, with emphasis on recent results based on lifetime signatures. The beauty cross sections in photoproduction and deep-inelastic scattering are found to be higher than expected in QCD at next-to-leading order. The discussion includes new results on beauty production in e+e-, gamma-gamma and p-bar-p interactions. An outlook on the potential for measurements with the upgraded HERA collider and experiments is also given.

  18. Therapeutic advances and future prospects in immune-mediated inflammatory myopathies.

    Science.gov (United States)

    Dalakas, Marinos C

    2008-11-01

    THE INFLAMMATORY MYOPATHIES INCLUDE THREE DISTINCT ENTITIES: polymyositis (PM), dermatomyositis (DM), and inclusion body myositis (IBM). A T-cell-mediated cytotoxic process in PM and IBM and a complement-mediated microangiopathy in DM are the hallmarks of the underlying autoimmune processes. The most consistent therapeutic problem remains the distinction of PM from the difficult-to-treat mimics such as s-IBM, necrotizing myopathies and inflammatory dystrophies. This review provides a step-by-step approach to the treatment of inflammatory myopathies, highlights the common pitfalls and mistakes in therapy, and identifies the emerging new therapies. In uncontrolled studies, PM and DM respond to prednisone to some degree and for some period of time, while a combination with one immu-nosuppressive drug (azathioprine, cyclosporine, mycophenolate, methotrexate) offers additional benefit or steroid-sparing effect. In contrast, IBM is resistant to most of these therapies, most of the time. Controlled studies have shown that IVIg is effective and safe for the treatment of DM, where is used as a second, and at times first, line therapy. IVIg seems to be also effective in the majority of patients with PM based on uncontrolled series, but it offers transient help to a small number of patients with IBM especially those with dysphagia. Bona fide patients with PM and DM who become resistant to the aforementioned therapies, may respond to rituximab, tacrolimus or rarely to an tumor necrosis factor alpha inhibitor. For IBM patients, experience with alemtuzumab, a T-cell-depleting monoclonal antibody, is encouraging.

  19. Beauty in the Breakdown

    Science.gov (United States)

    Brisco, Nicole

    2008-01-01

    Most human beings look at erosion as the destruction of a surface, but artists can see that erosion often creates indefinable beauty. Where do you see beauty in the breakdown? In this article, the author presents an innovative lesson that would allow students to observe both human and physical nature. In this activity students will create a work…

  20. Musings about Beauty

    Science.gov (United States)

    Kintsch, Walter

    2012-01-01

    In this essay, I explore how cognitive science could illuminate the concept of beauty. Two results from the extensive literature on aesthetics guide my discussion. As the term "beauty" is overextended in general usage, I choose as my starting point the notion of "perfect form." Aesthetic theorists are in reasonable agreement about the criteria for…

  1. Payments for scenic beauty

    OpenAIRE

    Jindal, Rohit; Kerr, John

    2007-01-01

    Although payments for scenic beauty are older than payment schemes for most other environmental services, scenic beauty itself is hard to define. It often encompasses a range of environmental services for consumptive (hunting, fishing) or non-consumptive (bird watching, boating) use. PES-1 (Payments for Environmental Services Associate Award)

  2. Host-Mediated Bioactivation of Pyrazinamide: Implications for Efficacy, Resistance, and Therapeutic Alternatives

    Science.gov (United States)

    Via, Laura E.; Savic, Rada; Weiner, Danielle M.; Zimmerman, Matthew D.; Prideaux, Brendan; Irwin, Scott M.; Lyon, Eddie; O’Brien, Paul; Gopal, Pooja; Eum, Seokyong; Lee, Myungsun; Lanoix, Jean-Philippe; Dutta, Noton K.; Shim, TaeSun; Cho, Jeong Su; Kim, Wooshik; Karakousis, Petros C.; Lenaerts, Anne; Nuermberger, Eric; Barry, Clifton E.; Dartois, Véronique

    2015-01-01

    Pyrazinamide has played a critical role in shortening therapy against drug-sensitive, drug-resistant, active, and latent tuberculosis (TB). Despite widespread recognition of its therapeutic importance, the sterilizing properties of this 60-year-old drug remain an enigma given its rather poor activity in vitro. Here we revisit longstanding paradigms and offer pharmacokinetic explanations for the apparent disconnect between in vitro activity and clinical impact. We show substantial host-mediated conversion of prodrug pyrazinamide (PZA) to the active form, pyrazinoic acid (POA), in TB patients and in animal models. We demonstrate favorable penetration of this pool of circulating POA from plasma into lung tissue and granulomas, where the pathogen resides. In standardized growth inhibition experiments, we show that POA exhibits superior in vitro potency compared to PZA, indicating that the vascular supply of host-derived POA may contribute to the in vivo efficacy of PZA, thereby reducing the apparent discrepancy between in vitro and in vivo activity. However, the results also raise the possibility that subinhibitory concentrations of POA generated by the host could fuel the emergence of resistance to both PZA and POA. In contrast to widespread expectations, we demonstrate good oral bioavailability and exposure in preclinical species in pharmacokinetic studies of oral POA. Baseline exposure of oral POA can be further increased by the xanthine oxidase inhibitor and approved gout drug allopurinol. These promising results pave the way for clinical investigations of oral POA as a therapeutic alternative or an add-on to overcome PZA resistance and salvage this essential TB drug. PMID:26086040

  3. Mechanisms of a novel anticancer therapeutic strategy involving atmospheric pressure plasma-mediated apoptosis and DNA strand break formation.

    Science.gov (United States)

    Chung, Woo-Hyun

    2016-01-01

    Atmospheric pressure plasma has been developed for a variety of biomedical applications due to its chemically reactive components. Recently, the plasma has emerged as a promising novel cancer therapy based on its ability to selectively ablate cancer cells while leaving normal cells essentially unaffected. The therapeutic effect of plasma is attributed to intracellular generation of reactive oxygen/nitrogen species (ROS/RNS) leading to mitochondria-mediated apoptosis and to activation of the DNA damage checkpoint signaling pathway via severe DNA strand break formation. However, the biochemical mechanisms responsible for appropriate activation of these physiological events and which pathway is more crucial for plasma-mediated cytotoxicity have not been clarified. Understanding the molecular link between ROS/RNS-mediated apoptosis and DNA damage-involved chromosome instability is critical for the development of more efficacious therapeutic strategies for selective killing of diverse cancer cells.

  4. Nitric oxide scavengers as a therapeutic approach to nitric oxide mediated disease.

    Science.gov (United States)

    Fricker, S P

    1999-08-01

    The essential role of nitric oxide (NO) in normal physiology and its involvement in the pathophysiology of a variety of diseases render the compound an attractive therapeutic target. NO donor drugs are used in the treatment of hypotension and angina where abnormalities in the L-arginine-nitric oxide pathway have been implicated. Overproduction of NO has been associated with a number of disease states including septic shock, inflammatory diseases, diabetes, ischaemia-reperfusion injury, adult respiratory distress syndrome, neurodegenerative diseases and allograft rejection. NO is produced by a group of enzymes, the nitric oxide synthases. Selective inhibition of the inducible isoform is one approach to the treatment of diseases where there is an overproduction of NO; an alternative approach is to scavenge or remove excess NO. A number of NO scavenger molecules have demonstrated pharmacological activity in disease models, particularly models of septic shock. These include organic molecules such as PTIO (2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide), haemoglobin derivatives such as the pyridoxalated haemoglobin polyoxyethylene conjugate (PHP), low molecular weight iron compounds of diethylenetriaminepentaacetic acid and diethyldithiocarbamate and ruthenium polyaminocarboxylate complexes. The data suggest a potential role for NO scavengers in the treatment of NO mediated disease. PMID:15992146

  5. Nrf2/ARE Signaling Pathway: Key Mediator in Oxidative Stress and Potential Therapeutic Target in ALS

    Directory of Open Access Journals (Sweden)

    Susanne Petri

    2012-01-01

    Full Text Available Nrf2 (nuclear erythroid 2-related factor 2 is a basic region leucine-zipper transcription factor which binds to the antioxidant response element (ARE and thereby regulates the expression of a large battery of genes involved in the cellular antioxidant and anti-inflammatory defence as well as mitochondrial protection. As oxidative stress, inflammation and mitochondrial dysfunctions have been identified as important pathomechanisms in amyotrophic lateral sclerosis (ALS, this signaling cascade has gained interest both with respect to ALS pathogenesis and therapy. Nrf2 and Keap1 expressions are reduced in motor neurons in postmortem ALS tissue. Nrf2-activating compounds have shown therapeutic efficacy in the ALS mouse model and other neurodegenerative disease models. Alterations in Nrf2 and Keap1 expression and dysregulation of the Nrf2/ARE signalling program could contribute to the chronic motor neuron degeneration in ALS and other neurodegenerative diseases. Therefore, Nrf2 emerges as a key neuroprotective molecule in neurodegenerative diseases. Our recent studies strongly support that the Nrf2/ARE signalling pathway is an important mediator of neuroprotection and therefore represents a promising target for development of novel therapies against ALS, Parkinson’s disease (PD, Huntington’s disease (HD, and Alzheimer’s disease (AD.

  6. Cycles of Beauty Culture: Ethnography of Beauty Clinics Commodification

    OpenAIRE

    Sri Murlianti

    2014-01-01

    Skin care is not a completely new in beauty treatments. Previously there have been other types of cultural industry which also adopted the medical science, such as cosmetic and beauty salon industries. But, skin care beauty clinic successfully introduces the services of beauty treatments which are considered the healthiest. This paper is a summary of the research on how beauty clinic quickly became a part of everyday life of its consumers. The research focused on Natasha Skin Care, a most pop...

  7. Utilizing redox-mediated Bergman cyclization toward the development of dual-action metalloenediyne therapeutics.

    Science.gov (United States)

    Lindahl, Sarah E; Park, Hyunsoo; Pink, Maren; Zaleski, Jeffrey M

    2013-03-13

    Reaction of 2 equiv of 1,2-bis((diphenylphosphino)ethynyl)benzene (dppeb, 1) with Pt(cod)Cl2 followed by treatment with N2H4 yields the reduced Pt(0) metalloenediyne, Pt(dppeb)2, 2. This complex is stable to both air oxidation and metal-mediated Bergman cyclization under ambient conditions due to the nearly idealized tetrahedral geometry. Reaction of 2 with 1 equiv of I2 in the presence of excess 1,4-cyclohexadiene (1,4-CHD) radical trap rapidly and near-quantitatively generates the cis-Bergman-cyclized, diiodo product 3 ((31)P: δ = 41 ppm, J(Pt-P) = 3346 Hz) with concomitant loss of 1 equiv of uncyclized phosphine chelate ((31)P: δ = -33 ppm). In contrast, addition of 2 equiv of I2 in the absence of additional radical trap instantaneously forms a metastable Pt(dppeb)2(2+) intermediate species, 4, that is characterized by δ = 51 ppm in the (31)P NMR (J(Pt-P) = 3171 Hz) and ν(C≡C) = 2169 cm(-1) in the Raman profile, indicating that it is an uncyclized, bis-ligated complex. Over 24 h, 4 undergoes ligand exchange to form a neutral, square planar complex that spontaneously Bergman cyclizes at ambient temperature to give the crystalline product Pt(dppnap-I2)I2 (dppnap-I2 = (1,4-diiodonaphthalene-2,3-diyl)bis(diphenylphosphine)), 5, in 52% isolated yield. Computational analysis of the oxidation reaction proposes two plausible flattened tetrahedral structures for intermediate 4: one where the phosphine core has migrated to a trans-spanning chelate geometry, and a second, higher energy structure (3.3 kcal/mol) with two cis-chelating phosphine ligands (41° dihedral angle) via a restricted alkyne-terminal starting point. While the energies are disparate, the common theme in both structures is the elongated Pt-P bond lengths (>2.4 Å), indicating that nucleophilic ligand substitution by I(-) is on the reaction trajectory to the cyclized product 5. The efficiency of the redox-mediated Bergman cyclization reaction of this stable Pt(0) metalloenediyne prodrug and

  8. Beauty in chemistry

    Directory of Open Access Journals (Sweden)

    Peter Atkins

    2006-03-01

    Full Text Available Though hard going for the general reader and highly personal in its selectivity, Elegant Solutions: Ten Beautiful Experiments in Chemistry provides reflections of a thoughtful author that will delight chemists

  9. Beauty in chemistry

    OpenAIRE

    Peter Atkins

    2006-01-01

    Though hard going for the general reader and highly personal in its selectivity, Elegant Solutions: Ten Beautiful Experiments in Chemistry provides reflections of a thoughtful author that will delight chemists

  10. Conference Summary - Beauty 2000

    OpenAIRE

    Stone, Sheldon

    2000-01-01

    Comment: 19 pages, 8 figures; to be published in Proceedings of Beauty 2000, Kibbutz Maagan, Israel, September, 2000, edited by S. Erhan, Y. Rozen, and P. E. Schlein, Nucl. Inst. Meth. A, 2001. Corrected references

  11. Neural correlates of beauty.

    Science.gov (United States)

    Kawabata, Hideaki; Zeki, Semir

    2004-04-01

    We have used the technique of functional MRI to address the question of whether there are brain areas that are specifically engaged when subjects view paintings that they consider to be beautiful, regardless of the category of painting (that is whether it is a portrait, a landscape, a still life, or an abstract composition). Prior to scanning, each subject viewed a large number of paintings and classified them into beautiful, neutral, or ugly. They then viewed the same paintings in the scanner. The results show that the perception of different categories of paintings are associated with distinct and specialized visual areas of the brain, that the orbito-frontal cortex is differentially engaged during the perception of beautiful and ugly stimuli, regardless of the category of painting, and that the perception of stimuli as beautiful or ugly mobilizes the motor cortex differentially.

  12. Beauty and the Books.

    Science.gov (United States)

    Smith, Jeanette C.

    1990-01-01

    Discusses the use of literature in the television program "Beauty and the Beast." Suggests that, despite his inhuman appearance, the Beast has transcended the physical confinement of the tunnels and has traveled the universe of his imagination. (RS)

  13. Ultrasound-mediated oncolytic virus delivery and uptake for increased therapeutic efficacy: state of art

    Directory of Open Access Journals (Sweden)

    Nande R

    2015-11-01

    Full Text Available Rounak Nande,1 Candace M Howard,2 Pier Paolo Claudio,3,4 1Department of Biochemistry and Microbiology, Marshall University School of Medicine, Huntington, WV, 2Department of Radiology, University of Mississippi Medical Center, Jackson, MS, 3Department of BioMolecular Sciences and National Center for Natural Products Research, School of Pharmacy, University of Mississippi, MS, 4Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, MS, USA Abstract: The field of ultrasound (US has changed significantly from medical imaging and diagnosis to treatment strategies. US contrast agents or microbubbles (MB are currently being used as potential carriers for chemodrugs, small molecules, nucleic acids, small interfering ribonucleic acid, proteins, adenoviruses, and oncolytic viruses. Oncolytic viruses can selectively replicate within and destroy a cancer cell, thus making them a powerful therapeutic in treating late-stage or metastatic cancer. These viruses have been shown to have robust activity in clinical trials when injected directly into tumor nodules. However limitations in oncolytic virus’ effectiveness and its delivery approach have warranted exploration of ultrasound-mediated delivery. Gene therapy bearing adenoviruses or oncolytic viruses can be coupled with MBs and injected intravenously. Following application of US energy to the target region, the MBs cavitate, and the resulting shock wave enhances drug, gene, or adenovirus uptake. Though the underlying mechanism is yet to be fully understood, there is evidence to suggest that mechanical pore formation of cellular membranes allows for the temporary uptake of drugs. This delivery method circumvents the limitations due to stimulation of the immune system that prevented intravenous administration of viruses. This review provides insight into this intriguing new frontier on the delivery of oncolytic viruses to tumor sites.Keywords: microbubbles, ultrasound

  14. Therapeutic impact of systemic AAV-mediated RNA interference in a mouse model of myotonic dystrophy.

    Science.gov (United States)

    Bisset, Darren R; Stepniak-Konieczna, Ewa A; Zavaljevski, Maja; Wei, Jessica; Carter, Gregory T; Weiss, Michael D; Chamberlain, Joel R

    2015-09-01

    RNA interference (RNAi) offers a promising therapeutic approach for dominant genetic disorders that involve gain-of-function mechanisms. One candidate disease for RNAi therapy application is myotonic dystrophy type 1 (DM1), which results from toxicity of a mutant mRNA. DM1 is caused by expansion of a CTG repeat in the 3' UTR of the DMPK gene. The expression of DMPK mRNA containing an expanded CUG repeat (CUG(exp)) leads to defects in RNA biogenesis and turnover. We designed miRNA-based RNAi hairpins to target the CUG(exp) mRNA in the human α-skeletal muscle actin long-repeat (HSA(LR)) mouse model of DM1. RNAi expression cassettes were delivered to HSA(LR) mice using recombinant adeno-associated viral (rAAV) vectors injected intravenously as a route to systemic gene therapy. Vector delivery significantly reduced disease pathology in muscles of the HSA(LR) mice, including a reduction in the CUG(exp) mRNA, a reduction in myotonic discharges, a shift toward adult pre-mRNA splicing patterns, reduced myofiber hypertrophy and a decrease in myonuclear foci containing the CUG(exp) mRNA. Significant reversal of hallmarks of DM1 in the rAAV RNAi-treated HSA(LR) mice indicate that defects characteristic of DM1 can be mitigated with a systemic RNAi approach targeting the nuclei of terminally differentiated myofibers. Efficient rAAV-mediated delivery of RNAi has the potential to provide a long-term therapy for DM1 and other dominant muscular dystrophies. PMID:26082468

  15. What Is Beauty?

    Institute of Scientific and Technical Information of China (English)

    胡应余

    2007-01-01

    <正> It seems that beauty and women are twins. You are joking? No, I am not. Observe for yourself. Ads on fashion flood TV screens, radio programs, magazines, newspapers, and the streets. Whether they have realized or not, women are besieged by a sea of fashions. They are taught to think that without beautiful clothes they will grow old and lose their charm. So who dares to neglect dressing up at the cost of their appearance and youth?

  16. The medicalization of beauty

    OpenAIRE

    Paulo Poli Neto; Sandra N.C. Caponi; Silvana Polchlopek

    2007-01-01

    Concern with body image and medical interventions related to physical beauty has greatly increased in the past few years. The purpose of this study is to investigate how medicine is dealing with the theme of beauty. The 2003/2004 editions of the periodicals Aesthetic Surgery Journal and Aesthetic Plastic Surgery were analyzed, in order to investigate the rationality buttressing their discourse. Three categories were prioritized for this study: definition of aesthetic plastic surgery's study o...

  17. BEAUTY'99 Conference Summary

    OpenAIRE

    Eerola, P.

    1999-01-01

    Investigations of B hadrons are expected to break new ground in measuring CP-violation effects. This series of BEAUTY conferences, originating from the 1993 conference in Liblice, has contributed significantly in developing ideas of CP-violation measurements using B hadrons and formulating and comparing critically the B-physics experiments. In the '99 conference in Bled we saw the ripening of the field and the first fruit emerging - Tevatron have produced beautiful B-physics results and more ...

  18. Chinese Beauty Rules

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Beijing beauty Zhang Zilin walked away with the Miss World 2007 crown before a partisan crowd on December 1,daz- zling the judging panel with her high-voltage smile and elegant confidence. The 23-year-old Miss China set the night alight in Sanya,in south China’s Hainan Province,when she emerged from a bevy of 106 of the world’s most beautiful women to become China’s first Miss World in 57 years

  19. A school peer mediation program as a context for exploring therapeutic jurisprudence (TJ): Can a peer mediation program inform the law?

    Science.gov (United States)

    McWilliam, Nicky

    2010-01-01

    This paper reports an exploratory study of a school peer mediation program implemented as an alternative way to manage bullying and other destructive conflict. The study explores the effects of the program on the well-being of members of the school community by examining perceptions of students, staff and a sample of parents and former students. Drawing on therapeutic jurisprudence (TJ) the study explores whether the component parts of the program, separately or together, promote intended or unintended therapeutic effects. The preliminary findings of the study emphasise the importance of peer mediation training and suggest that existing scholarship in the area of school conflict resolution and peer mediation, when viewed through a TJ lens, may provide valuable insights into how to optimally configure programs for development and adoption in schools and other community settings. The study highlights the lack of attention paid by the legal system to valuable scholarship in the area of school conflict resolution and peer mediation, which may have implications for the understanding and development of legal processes and the law in general.

  20. Therapeutic effects of lentivirus-mediated shRNA targeting of cyclin D1 in human gastric cancer

    International Nuclear Information System (INIS)

    Gastric cancer is the second most common cause of cancer-related death in males and the fourth in females. Traditional treatment has poor prognosis because of recurrence and systemic side effects. Therefore, the development of new therapeutic strategies is an important issue. Lentivirus-mediated shRNA stably inhibits target genes and can efficiently transduce most cells. Since overexpressed cyclin D1 is closely related to human gastric cancer progression, inhibition of cyclin D1 using specific targeting could be an effective treatment method of human gastric cancer. The therapeutic effect of lentivirus-mediated shRNA targeting of cyclin D1 (ShCCND1) was analyzed both in vitro and in vivo experiments. In vitro, NCI-N87 cells with downregulation of cyclin D1 by ShCCND1 showed significant inhibition of cell proliferation, cell motility, and clonogenicity. Downregulation of cyclin D1 in NCI-N87 cells also resulted in significantly increased G1 arrest and apoptosis. In vivo, stable NCI-N87 cells expressing ShCCND1 were engrafted into nude mice. Then, the cancer-growth inhibition effect of lentivirus was confirmed. To assess lentivirus including ShCCND1 as a therapeutic agent, intratumoral injection was conducted. Tumor growth of the lentivirus-treated group was significantly inhibited compared to growth of the control group. These results are in accordance with the in vitro data and lend support to the mitotic figure count and apoptosis analysis of the tumor mass. The lentivirus-mediated ShCCND1 was constructed, which effectively inhibited growth of NCI-N87-derived cancer both in vitro and in vivo. The efficiency of shRNA knockdown and variation in the degree of inhibition is mediated by different shRNA sequences and cancer cell lines. These experimental results suggest the possibility of developing new gastric cancer therapies using lentivirus-mediated shRNA

  1. Clinical study on safety and immunogenicity of therapeutic dual-plasmid HBV DNA vaccine mediated by in vivo electroporation

    Directory of Open Access Journals (Sweden)

    Hai-yan YANG

    2013-03-01

    Full Text Available Objective  To evaluate the safety and immunogenicity of the therapeutic dual-plasmid HBV DNA vaccine mediated by electroporation (EP in vivo against the hepatitis B virus in healthy adult volunteers. Methods The enrolled 30 healthy volunteers were randomly divided into three dosage groups (10 volunteers in each group, namely: high-dose (4mg, middle-dose (2mg and low-dose (1mg groups. Volunteers received four intramuscular injections of HBV DNA vaccine mediated by in vivo EP at the 0, 4th, 12th and 24th week. Each dose group was further divided into 2 sub-groups (5 persons/per group with different EP frequencies, i.e. 36 and 60 volt. The changes in response was determined by physical diagnosis (ECG, chest X-ray, type-B ultrasound, lab findings (blood and urine routine, blood biochemistry, prothrombin time, thyroid function, tumor biomarkers, immunological variables (IFN-γ, ANA, anti-dsDNA Ab, serological variables pertaining to HBV (HBsAg, HBcAb, HBeAg, HBeAb, HBV DNA and serum anti-HBs status in volunteers before and after receiving EP mediated HBV DNA vaccination. Results The dual-plasmid HBV DNA vaccination mediated by in vivo EP was well tolerated in all healthy volunteers with a stable life signs. It was found that EP-mediated immunization of the therapeutic DNA vaccine against hepatitis B virus had a specific and obvious anti-HBs humoral immune response in one volunteer (17.22mU/ml. Four repeated intramuscular injections of the vaccine did not show any significant adverse effects in the receptors. Although mild elevation of serum ALT and enlarged spleen were found in one individual, the abnormalities disappeared spontaneously at the end of the trial. Conclusions EP-mediated dual-plasmid HBV DNA vaccine is safe and well tolerated with certain degree of humoral immunogenicity.

  2. Why Beauty Matters

    OpenAIRE

    Rosenblat, Tanya; Mobius, Markus

    2006-01-01

    We decompose the beauty premium in an experimental labor market where “employers†determine wages of “workers†who perform a maze-solving task. This task requires a true skill which we show to be unaffected by physical attractiveness. We find a sizable beauty premium and can identify three transmission channels: (a) physically attractive workers are more confident and higher confidence increases wages; (b) for a given level of confidence, physically attractive workers are (wrongly) cons...

  3. Beauty in Hume's Viewpoint

    OpenAIRE

    Ali Salmani

    2010-01-01

    Although Hume, regarding his basic ideas, explicitly identifies beauty as a sentiment, but in some passages it is introduced not as a sentiment but as a real quality. In some other passages, it also seemed like a secondary quality. Some interpreters, just by referring to these unclear passages in Hume’s writings, offered a kind of interpretations from Hume’s basic idea of beauty that finally is incompatible with his entire philosophy. We attempt, in this paper, by presenting the Hume’s theory...

  4. Introduction to Beautiful Soup

    Directory of Open Access Journals (Sweden)

    Jeri Wieringa

    2012-12-01

    Full Text Available Beautiful Soup is a Python library for getting data out of HTML, XML, and other markup languages. Say you’ve found some webpages that display data relevant to your research, such as date or address information, but that do not provide any way of downloading the data directly. Beautiful Soup helps you pull particular content from a webpage, remove the HTML markup, and save the information. It is a tool for web scraping that helps you clean up and parse the documents you have pulled down from the web.

  5. Introduction to Beautiful Soup

    OpenAIRE

    Jeri Wieringa

    2012-01-01

    Beautiful Soup is a Python library for getting data out of HTML, XML, and other markup languages. Say you’ve found some webpages that display data relevant to your research, such as date or address information, but that do not provide any way of downloading the data directly. Beautiful Soup helps you pull particular content from a webpage, remove the HTML markup, and save the information. It is a tool for web scraping that helps you clean up and parse the documents you have pulled down from t...

  6. Who Engages with Moral Beauty?

    Science.gov (United States)

    Diessner, Rhett; Iyer, Ravi; Smith, Meghan M.; Haidt, Jonathan

    2013-01-01

    Aristotle considered moral beauty to be the "telos" of the human virtues. Displays of moral beauty have been shown to elicit the moral emotion of elevation and cause a desire to become a better person and to engage in prosocial behavior. Study 1 ("N" = 5380) shows engagement with moral beauty is related to several psychological…

  7. My Beautiful Friend

    Institute of Scientific and Technical Information of China (English)

    雷全

    2004-01-01

    I have many toys in my room.Al-though they can’t speak,I treat them asmy friends.I like playing with them.Among them,my favorite is the beautiful girl-Barbiedoll.Her name is Kelly,same as my English name.She cameto my family a year ago as my birthday gift.

  8. A Window of Beauty

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Yan Hong (front, third from the right), Mr Leo Passage, President of Pivot Point (front, second from the right) and Peng Jinzhao, President of Pivot Point—Asia Region (front, fourth from the right) with the students of the Sichuan Pivot Point Beauty Institute.

  9. Spectroscopy of beautiful baryons

    Energy Technology Data Exchange (ETDEWEB)

    Caloi, R.; Gentile, S.; Mignani, R. (Rome Univ. (Italy). Ist. di Fisica)

    1980-09-20

    By assuming a non-relativistic quark model, an estimate of the masses of the low-lying (non-strange and non-charmed) beautiful baryons is given. Electromagnetic mass splittings of the same baryons are also discussed in some detail.

  10. Therapeutic Blockade of Immune Complex-Mediated Glomerulonephritis by Highly Selective Inhibition of Bruton’s Tyrosine Kinase

    Science.gov (United States)

    Chalmers, Samantha A.; Doerner, Jessica; Bosanac, Todd; Khalil, Sara; Smith, Dustin; Harcken, Christian; Dimock, Janice; Der, Evan; Herlitz, Leal; Webb, Deborah; Seccareccia, Elise; Feng, Di; Fine, Jay S.; Ramanujam, Meera; Klein, Elliott; Putterman, Chaim

    2016-01-01

    Lupus nephritis (LN) is a potentially dangerous end organ pathology that affects upwards of 60% of lupus patients. Bruton’s tyrosine kinase (BTK) is important for B cell development, Fc receptor signaling, and macrophage polarization. In this study, we investigated the effects of a novel, highly selective and potent BTK inhibitor, BI-BTK-1, in an inducible model of LN in which mice receive nephrotoxic serum (NTS) containing anti-glomerular antibodies. Mice were treated once daily with vehicle alone or BI-BTK-1, either prophylactically or therapeutically. When compared with control treated mice, NTS-challenged mice treated prophylactically with BI-BTK-1 exhibited significantly attenuated kidney disease, which was dose dependent. BI-BTK-1 treatment resulted in decreased infiltrating IBA-1+ cells, as well as C3 deposition within the kidney. RT-PCR on whole kidney RNA and serum profiling indicated that BTK inhibition significantly decreased levels of LN-relevant inflammatory cytokines and chemokines. Renal RNA expression profiling by RNA-seq revealed that BI-BTK-1 dramatically modulated pathways related to inflammation and glomerular injury. Importantly, when administered therapeutically, BI-BTK-1 reversed established proteinuria and improved renal histopathology. Our results highlight the important role for BTK in the pathogenesis of immune complex-mediated nephritis, and BTK inhibition as a promising therapeutic target for LN. PMID:27192942

  11. Investigations by Cell-Mediated Immunologic Tests and Therapeutic Trials With Thymopentin in Vaginal Mycoses

    OpenAIRE

    Werner Mendling; Ursula Koldovsky

    1996-01-01

    Objective: According to unsatisfactory therapeutic results in patients with chronically recurrent vaginal candidosis, we investigated if immunologic patient factors could be found and treated. Methods: In 42 women with chronically recurrent and 20 women with acute Candida albicans vulvovaginitis, as well as 14 women with C. glabrata vaginitis, the following investigations were carried out: identification of yeast species; quantification of T lymphocytes and their subpopulations in sera; proli...

  12. Therapeutic complement inhibition in complement-mediated hemolytic anemias: Past, present and future.

    Science.gov (United States)

    Risitano, Antonio M; Marotta, Serena

    2016-06-01

    The introduction in the clinic of anti-complement agents represented a major achievement which gave to physicians a novel etiologic treatment for different human diseases. Indeed, the first anti-complement agent eculizumab has changed the treatment paradigm of paroxysmal nocturnal hemoglobinuria (PNH), dramatically impacting its severe clinical course. In addition, eculizumab is the first agent approved for atypical Hemolytic Uremic Syndrome (aHUS), a life-threatening inherited thrombotic microangiopathy. Nevertheless, such remarkable milestone in medicine has brought to the fore additional challenges for the scientific community. Indeed, the list of complement-mediated anemias is not limited to PNH and aHUS, and other human diseases can be considered for anti-complement treatment. They include other thrombotic microangiopathies, as well as some antibody-mediated hemolytic anemias. Furthermore, more than ten years of experience with eculizumab led to a better understanding of the individual steps of the complement cascade involved in the pathophysiology of different human diseases. Based on this, new unmet clinical needs are emerging; a number of different strategies are currently under development to improve current anti-complement treatment, trying to address these specific clinical needs. They include: (i) alternative anti-C5 agents, which may improve the heaviness of eculizumab treatment; (ii) broad-spectrum anti-C3 agents, which may improve the efficacy of anti-C5 treatment by intercepting the complement cascade upstream (i.e., preventing C3-mediated extravascular hemolysis in PNH); (iii) targeted inhibitors of selective complement activating pathways, which may prevent early pathogenic events of specific human diseases (e.g., anti-classical pathway for antibody-mediated anemias, or anti-alternative pathway for PNH and aHUS). Here we briefly summarize the status of art of current and future complement inhibition for different complement-mediated anemias

  13. ON BEAUTY AND THE BEAUTIFUL IN AESTHETIC EDUCATION

    Directory of Open Access Journals (Sweden)

    Borce Kostov

    2013-06-01

    Full Text Available We titled our work “On Beauty and the Beautiful in Aesthetic Education” and we analyzed the category beautiful in function of better understanding the issues of aesthetic education.The basic point was the fact that the determination of the term beautiful is being different in both, time aspect and space aspect. Also, the authors involved in this matter have got different understanding on beautiful issue, on its essence, on its role in human development and on the development of the aesthetics and the aesthetic education.Therefore, within our work, there is an attempt to differ the approaches towards the category beautiful, to comment it, to compare it and finally to give our approach.

  14. The face, beauty, and symmetry: perceiving asymmetry in beautiful faces.

    Science.gov (United States)

    Zaidel, D W; Cohen, J A

    2005-08-01

    The relationship between bilateral facial symmetry and beauty remains to be clarified. Here, straight head-on photographs of "beautiful" faces from the collections of professional modeling agencies were selected. First, beauty ratings were obtained for these faces. Then, the authors created symmetrical left-left and right-right composites of the beautiful faces and asked a new group of subjects to choose the most attractive pair member. "Same" responses were allowed. No difference between the left-left and right-right composites was revealed but significant differences were obtained between "same" and the left-left or right-right. These results show that subjects detected asymmetry in beauty and suggest that very beautiful faces can be functionally asymmetrical. PMID:16040358

  15. The face, beauty, and symmetry: Perceiving asymmetry in beautiful faces

    OpenAIRE

    Zaidel, Dr. Dahlia W.; Cohen, Jennifer A.

    2005-01-01

    The relationship between bilateral facial symmetry and beauty remains to be clarified. Here, straight head-on photographs of “beautiful” faces from the collections of professional modeling agencies were selected. First, beauty ratings were obtained for these faces. Then, the authors created symmetrical left-left and right-right composites of the beautiful faces and asked a new group of subjects to choose the most attractive pair member. “Same” responses were allowed. No difference between the...

  16. Burns and beauty nails

    Science.gov (United States)

    Bélanger, Richard E; Marcotte, Marie-Eve; Bégin, François

    2013-01-01

    A case involving a five-month-old girl brought to the emergency department with burns over her abdomen is described. The child was reported to have spilled two small bottles of beauty nail adhesive on her clothes while her mother was preparing dinner. After undressing the infant, the mother discovered several lesions on the child’s abdomen and quickly sought medical attention. Given the unusual circumstances of the presentation, the child was hospitalized for both treatment and supervision. The beauty nail adhesive contained cyanoacrylate. In addition to its well-appreciated adhesive capacity, cyanoacrylate, in the presence of cotton or other tissues, is known to produce an exothermic reaction that may cause burns. Cyanoacrylate-based products, due to their possible adverse effects, should be kept away from children as advised. Odd injuries should always raise concerns about the possibility of inflicted injury. PMID:24421671

  17. Small is beautiful

    Energy Technology Data Exchange (ETDEWEB)

    Schumacher, E.F.

    1973-01-01

    The author feels that ''an almost universal idolatry of gigantism'' has caused the urgent crisis of today's society. The book expresses his philosophy of the beauty of thinking in less grandiose terms. He offers some smaller-scale yet highly feasible solutions to many of the problems created by bigness--the environmental crisis, the energy shortage, the dehumanization of industrial workers, the flight from rural areas, and the decay of cities. (MCW)

  18. Burns and beauty nails

    OpenAIRE

    Richard E. Bélanger; Marcotte, Marie-Eve; Bégin, François

    2013-01-01

    A case involving a five-month-old girl brought to the emergency department with burns over her abdomen is described. The child was reported to have spilled two small bottles of beauty nail adhesive on her clothes while her mother was preparing dinner. After undressing the infant, the mother discovered several lesions on the child’s abdomen and quickly sought medical attention. Given the unusual circumstances of the presentation, the child was hospitalized for both treatment and supervision. T...

  19. Shibusa: extracting beauty

    OpenAIRE

    Adkins, Monty; Dickens, Pip

    2012-01-01

    Shibusa – Extracting Beauty celebrates a number of artistic endeavours: music, painting and the skill of making in general with particular reflection upon Japanese aesthetics. Composer, Monty Adkins and visual artist, Pip Dickens (through a Leverhulme Trust Award collaboration) investigate commonality and difference between the visual arts and music exploring aspects of rhythm, pattern, colour and vibration as well as outlining processes utilised to evolve new works within these practic...

  20. Sublimity, beauty and decorum

    OpenAIRE

    White, Luke

    2007-01-01

    This catalogue essay examines the work of two contemporary abstract painters, Maisie Kendall and Richmond Burton, who were showing together at the Royal Academy Schools Gallery in London, in Autumn 2007. It traces the fate of the "decorative" in modern art, and relates this term to Neoclassical attitudes to decorum. Tracing the turn away from decorum as a validating term in art, with the rise of the related (and gendered) notions of the sublime and the beautiful (with the privileging of the f...

  1. Politics of Beauty

    OpenAIRE

    Ken-ichi Sasaki

    2011-01-01

    I look back at the history of modern aesthetics to grasp its current situation and to propose its possibilities for the future. The early modern period, during which aesthetics came into being, was a great historical turning point for civilization. Our contemporary period shares this character, and it is worthwhile for us to consult its history in order to reflect on our civilization. Aesthetics began with Baumgarten’s proposal, which consisted in a triple subject: sensibility, beauty, an...

  2. A Beautiful Spin

    International Nuclear Information System (INIS)

    Spin is a beautiful concept that plays an ever important role in modern physics. In this talk, I start with a discussion of the origin of spin, and then turn to three themes in which spin has been crucial in subatomic physics: a lab to explore physics beyond the standard model, a tool to measure physical observables that are hard to obtain otherwise, a probe to unravel nonperturbative QCD. I conclude with some remarks on a world without spin

  3. A beautiful theory

    OpenAIRE

    Ed Nosal; Peter Rupert

    2002-01-01

    It wasn’t A Beautiful Mind—the book or the movie—that made John Forbes Nash, Jr., famous. It was his work in game theory, a theory that models strategic interactions between people as games. Before Nash, the only games theorists could get a handle on were artificial ones with no real-world applications. Nash’s insights enabled economists to expand the use of game theory to interesting practical problems.

  4. Autistic functioning and therapeutical dimension of mediations (Tome 1 and 2)

    OpenAIRE

    Chocron, Michael

    2012-01-01

    Care for subjects with autistic or related disorders in medical institutes is mainly based on activities using mediation. This research deals with the caring of youngsters with Pervasive Developmental Disorder in a medical institute. Using both autobiographical work from author with autism and case study of psychotherapeutic follow-up in a medical institute, the idea of autistic functioning will be exposed. This idea is a way to comprehend psychic process mostly seen in autistic persons. In a...

  5. Two beautiful new particles

    CERN Multimedia

    Antonella Del Rosso

    2012-01-01

    In beautiful agreement with the Standard Model, two new excited states (see below) of the Λb beauty particle have just been observed by the LHCb Collaboration. Similarly to protons and neutrons, Λb is composed of three quarks. In the Λb’s case, these are up, down and… beauty.   Although discovering new particles is increasingly looking like a routine exercise for the LHC experiments (see previous features), it is far from being an obvious performance, particularly when the mass of the particles is high. Created in the high-energy proton-proton collisions produced by the LHC, these new excited states of the Λb particle have been found to have a mass of, respectively, 5912 MeV/c2 and 5920 MeV/c2. In other words, they are over five times heavier than the proton or the neutron. Physicists only declare a discovery when data significantly show the relevant signal. In order to do that, they often have to analyse large samples of data. To ...

  6. Preasymptotic effects in beauty decays

    OpenAIRE

    Guberina, B.; Melic, B.; Stefancic, H.

    2000-01-01

    Large preasymptotic effects in beauty decays have been found using heavy-quark and SU(3) symmetry, as well as experimental data on charmed hyperons. Contrary to rather uniform beauty-meson lifetimes, a much larger spread of beauty-baryon lifetimes is predicted. However, it is highly unlikely that, theoretically, the $ \\tau(\\Lambda_b)/\\tau(B_d^0) $ ratio, which at present deviates more than $1\\sigma$ from the experimental result, can be lowered below 0.9.

  7. Hadroproduction of Charm and Beauty

    OpenAIRE

    Karchin, Paul E.

    1997-01-01

    Recent results on the hadroproduction of charm and beauty are discussed in the context of the current theoretical and experimental status. The areas covered include production of open charm and beauty particles and charm and beauty quarkonia. Experimental results from both fixed target and colliding beam experiments are presented and compared to theoretical predictions. Predictions based on QCD perturbation theory are generally successful in explaining the shapes of differential cross section...

  8. HIF-mediated innate immune responses: cell signaling and therapeutic implications

    Directory of Open Access Journals (Sweden)

    Harris AJ

    2014-05-01

    Full Text Available Alison J Harris, AA Roger Thompson, Moira KB Whyte, Sarah R Walmsley Academic Unit of Respiratory Medicine, Department of Infection and Immunity, University of Sheffield, Sheffield, UK Abstract: Leukocytes recruited to infected, damaged, or inflamed tissues during an immune response must adapt to oxygen levels much lower than those in the circulation. Hypoxia inducible factors (HIFs are key mediators of cellular responses to hypoxia and, as in other cell types, HIFs are critical for the upregulation of glycolysis, which enables innate immune cells to produce adenosine triphosphate anaerobically. An increasing body of evidence demonstrates that hypoxia also regulates many other innate immunological functions, including cell migration, apoptosis, phagocytosis of pathogens, antigen presentation and production of cytokines, chemokines, and angiogenic and antimicrobial factors. Many of these functions are mediated by HIFs, which are not only stabilized posttranslationally by hypoxia, but also transcriptionally upregulated by inflammatory signals. Here, we review the role of HIFs in the responses of innate immune cells to hypoxia, both in vitro and in vivo, with a particular focus on myeloid cells, on which the majority of studies have so far been carried out. Keywords: hypoxia, neutrophils, monocytes, macrophages

  9. Glycoprotein non-metastatic b (GPNMB: A metastatic mediator and emerging therapeutic target in cancer

    Directory of Open Access Journals (Sweden)

    Maric G

    2013-07-01

    Full Text Available Gordana Maric,1,2 April AN Rose,3 Matthew G Annis,1,2 Peter M Siegel1,2,4,5 1Goodman Cancer Research Centre, 2Department of Medicine, 3Faculty of Medicine, 4Department of Biochemistry, 5Department of Anatomy and Cell Biology, McGill University, Montréal, Québec, Canada Abstract: Molecularly targeted therapies are rapidly growing with respect to their clinical development and impact on cancer treatment due to their highly selective anti-tumor action. However, many aggressive cancers such as triple-negative breast cancer (TNBC currently lack well-defined therapeutic targets against which such agents can be developed. The identification of tumor-associated antigens and the generation of antibody drug-conjugates represent an emerging area of intense interest and growth in the field of cancer therapeutics. Glycoprotein non-metastatic b (GPNMB has recently been identified as a gene that is over-expressed in numerous cancers, including TNBC, and often correlates with the metastatic phenotype. In breast cancer, GPNMB expression in the tumor epithelium is associated with a reduction in disease-free and overall survival. Based on these findings, glembatumumab vedotin (CDX-011, an antibody-drug conjugate that selectively targets GPNMB, is currently being investigated in clinical trials for patients with metastatic breast cancer and unresectable melanoma. This review discusses the physiological and potential pathological roles of GPNMB in normal and cancer tissues, respectively, and details the clinical advances and challenges in targeting GPNMB-expressing malignancies. Keywords: GPNMB, osteoactivin, breast cancer, antibody-drug conjugates, CDX-011

  10. Leptin inhibitors from fungal endophytes (LIFEs): Will be novel therapeutic drugs for obesity and its associated immune mediated diseases.

    Science.gov (United States)

    Chandra Mouli, K; Pragathi, D; Naga Jyothi, U; Shanmuga Kumar, V; Himalaya Naik, M; Balananda, P; Suman, B; Seshadri Reddy, V; Vijaya, T

    2016-07-01

    Treatment of obesity and its associated immune mediated diseases is challenging due to impaired function of leptin system. Thus leptin is providing an interesting target for therapeutic intervention. Leptin, an adipose tissue-derived adipokine, displays a variety of immune functions, and regulate both innate and adaptive immune responses. The increased secretion of leptin (hyperleptinemia) and production of proinflammatory cytokines has been implicated in the pathogenesis of obesity-related immune diseases such as diabetes mellitus, hypertension, atherosclerosis, cancer, systemic lupus erythematosus, rheumatoid arthritis, crohn's disease and multiple sclerosis. These disorders are managed through antibiotics and by cytokines replacement. However, the effectiveness of cytokines coupled to the complexity of the cytokine network leads to severe side-effects, which can still occur after careful preclinical evaluation. In addition, synthetic immunotherapeutics carries a degree of risk, is time-consuming and expensive. Hence, the complexity of existing therapy and adverse effects emphasizes the need of an alternative approach for the management of immune dysfunction associated with obesity and its related diseases. For the aforementioned diseases that are related to leptin overabundance, new drugs blocking leptin signaling need to be generated. The research on the discovery of clinically important novel compounds from natural source is expanding due to their safety and no side effect. The fungal endophytes are the microbes that colonize internal tissue of plants without causing negative effects to the host. They produce plethora of substances of potential use to modern medicinal and pharmaceutical industry. The increasing body of evidence associated with application of bioactive metabolites derived from fungal endophytes in diverse disease states merits its use as therapeutic drugs. In particular, the saponins have been extensively proved to modulate the immune system

  11. BEAUTIFUL, SENSE OF BEAUTY AND ELEMENTS OF BEAUTY IN TURKISH “MÂNİ”

    OpenAIRE

    Bülent Kahraman Çolakoğlu

    2014-01-01

    This study underlines the “mâni” which represents anonymous folk literature reflecting Turkish cultural life. Turkish nation’s sense of beautiful and beauty, the elements of beauty which belong to beauty/beloved have been studied with reference to Turkish “mâni” in order to protect Turkish cultural treasures and ensure them to be inherited from generation to generation by functionalizing them. In the study, content analysis has been used in the process of data interpretation. 4068 “mâni”s...

  12. Physiological and Therapeutic Vascular Remodeling Mediated by Hypoxia-Inducible Factor 1

    Science.gov (United States)

    Sarkar, Kakali; Semenza, Gregg L.

    Angiogenesis along with arteriogenesis and vasculogenesis is a fundamental process in ischemic repair in adult animals including humans. Hypoxia-inducible factor 1 (HIF-1) plays a central role in mediating adaptive responses to hypoxia/ischemia by expressing angiogenic cytokines/growth factors and their cognate receptors. Angiogenic growth factors are the homing signal for circulating angiogenic cells (CACs), which are mobilized to peripheral blood from bone marrow, recruited to target tissues, and promote vascularization. Impairment of HIF-1-mediated gene transcription contributes to the impaired vascular responses in peripheral vascular disease that are associated with aging and diabetes. Promoting neovascularization in ischemic tissues is a promising strategy for the treatment of peripheral vascular disease when surgical or catheter-based revascularization is not possible. Intramuscular injection of an adenovirus encoding a constitutively active form of HIF-1α (AdCA5), into the ischemic limb of diabetic mice increases the recovery of limb perfusion and function, rescues the diabetes-associated impairment of CACs, and increases vascularization. Administration of AdCA5 overcomes the effect of aging on recovery of blood flow in middle-aged mice following femoral artery ligation in a mouse model of age-dependent critical limb ischemia. Intramuscular injection of AdCA5 along with intravenous injection of bone-marrow-derived angiogenic cells cultured in the presence of prolyl-4-hydroxylase inhibitor dimethyloxalylglycine, increases blood flow and limb salvage in old mice following femoral artery ligation. HIF-1α gene therapy increases homing of bone-marrow-derived cells, whereas induction of HIF-1 in these cells increases their retention in the ischemic tissue by increasing their adhesion to endothelium leading to synergistic effects of combined therapy on improving blood flow.

  13. Peptide-Mediated Delivery of Chemical Probes and Therapeutics to Mitochondria.

    Science.gov (United States)

    Jean, Sae Rin; Ahmed, Marya; Lei, Eric K; Wisnovsky, Simon P; Kelley, Shana O

    2016-09-20

    Mitochondria are organelles with critical roles in key processes within eukaryotic cells, and their dysfunction is linked with numerous diseases including neurodegenerative disorders and cancer. Pharmacological manipulation of mitochondrial function is therefore important both for basic science research and eventually, clinical medicine. However, in comparison to other organelles, mitochondria are difficult to access due to their hydrophobic and dense double membrane system as well as their negative membrane potential. To tackle the challenge of targeting these important subcellular compartments, significant effort has been put forward to develop mitochondria-targeted systems capable of transporting bioactive cargo into the mitochondrial interior. Systems now exist that utilize small molecule, peptide, liposome, and nanoparticle-based transport. The vectors available vary in size and structure and can facilitate transport of a variety of compounds for mitochondrial delivery. Notably, peptide-based delivery scaffolds offer attractive features such as ease of synthesis, tunability, biocompatibility, and high uptake both in cellulo and in vivo. Owing to their simple and modular synthesis, these peptides are highly adaptable for delivering chemically diverse cargo. Key design features of mitochondria-targeted peptides include cationic charge, which allows them to harness the negative membrane potential of mitochondria, and lipophilicity, which permits favorable interaction with hydrophobic membranes of mitochondria. These peptides have been covalently tethered to target therapeutic agents, including anticancer drugs, to enhance their drug properties, and to provide probes for mitochondrial biology. Interestingly, mitochondria-targeted DNA damaging agents demonstrate high potency and the ability to evade resistance mechanisms and off-target effects. Moreover, a combination of mitochondria-targeted DNA damaging agents was applied to an siRNA screen for the elucidation of

  14. Beauty and Testimony

    OpenAIRE

    Hopkins, Robert

    2000-01-01

    I ask whether, and how far, it is possible legitimately to acquire the belief that a given item is beautiful on the basis of someone's testimony that it is. This is an issue that concerned Kant. Kant held that testimony could never be a legitimate source of such judgements, and clearly took his account of aesthetic judgement to explain this fact. I argue that Kant's theory does not, in fact, provide the materials for a satisfactory explanation. Was Kant at least right about the explanadum? Wh...

  15. A Corporate Beauty Contest

    OpenAIRE

    Graham, John R.; Campbell R. Harvey; Manju Puri

    2010-01-01

    We conduct beauty contest experiments, using close to 2,000 subjects to study the facial traits of CEOs. In one experiment we use pairs of photographs and find that subjects rate CEO faces as appearing more "competent" and less "likable" than non-CEO faces. Another experiment matches CEOs from large firms against CEOs from smaller firms and finds large-firm CEOs look more competent and likable. In a third experiment, subjects numerically rate the facial traits of CEOs. We find that executive ...

  16. Beauty97 Conference Summary

    OpenAIRE

    Erhan, Samim

    1998-01-01

    CP-violation is one of the least understood phenomena in our field. There are major experimental programs in all high energy laboratories around the world which will hopefully remedy this within the next decade. The study of CP-violating effects in B meson decays will allow stringent tests of the Standard Model to be made and may point the way to New Physics. The Beauty97 conference provided a forum for these experiments to discuss their physics potential and experimental challenges relating ...

  17. Theory of Beauty Lifetimes

    OpenAIRE

    Neubert, Matthias(PRISMA Cluster of Excellence and Mainz Institut for Theoretical Physics, Johannes Gutenberg University, 55099, Mainz, Germany)

    1997-01-01

    A critical review of the theoretical understanding of the lifetimes of beauty hadrons is given. A model-independent analysis using the heavy-quark expansion allows for a description of the lifetime ratios tau(B-)/tau(B0) and tau(Lambda_b)/tau(B0) in a small region of parameter space. It is demonstrated that the lifetime ratio tau(B-)/tau(B0) cannot be used to extract the decay constant of the B meson. Implications for the semileptonic branching ratio and charm yield in B decays are pointed out.

  18. A Beautiful Story

    Science.gov (United States)

    García-Moliner, Federico

    In 1981, a time when our science administrators still believed that small is beautiful, I was sent to Cuba with a very simple mission: To establish contact with the solid state physicists at the University of Havana in order to identify affinities and prepare the ground for possible collaborations. I count this as one of the most fortunate events in my professional and human experience. It marked the beginning of a long lasting and very fruitful collaboration as well as of many brotherly friendships that have significantly contributed to the enrichment of my life as a human being.

  19. She Looks so Beautiful

    OpenAIRE

    Karen de Kock

    2008-01-01

    This article offers a story that illustrates how the medium of music is able to provide comfort, even in extreme cases of hopelessness, when all other efforts seem futile. I will relate how the creative act of music-making within an institutional setting, was able to provide comfort to a self-injurious female psychiatric client, who had been institutionalised all her life, to restore a sense of beauty and dignity which had been lost. The music that was created in the moment was also able to c...

  20. Fucose decorated solid-lipid nanocarriers mediate efficient delivery of methotrexate in breast cancer therapeutics.

    Science.gov (United States)

    Garg, Neeraj K; Singh, Bhupinder; Jain, Ashay; Nirbhavane, Pradip; Sharma, Rajeev; Tyagi, Rajeev K; Kushwah, Varun; Jain, Sanyog; Katare, Om Prakash

    2016-10-01

    The present study is designed to engineer fucose anchored methotrexate loaded solid lipid nanoparticles (SLNs) to target breast cancer. The developed nano-carriers were characterized with respect to particle size, PDI, zeta potential, drug loading and entrapment, in-vitro release etc. The characterized formulations were used to comparatively assess cellular uptake, cell-viability, apoptosis, lysosomal membrane permeability, bioavailability, biodistribution, changes in tumor volume and animal survival. The ex-vivo results showed greater cellular uptake and better cytotoxicity at lower IC50 of methotrexate in breast cancer cells. Further, we observed increased programmed cell death (apoptosis) with altered lysosomal membrane permeability and better rate of degradation of lysosomal membrane in-vitro. On the other hand, in-vivo evaluation showed maximum bioavailability and tumor targeting efficiency with minimum secondary drug distribution in various organs with formulated and anchored nano-carrier when compared with free drug. Moreover, sizeable reduction in tumor burden was estimated with fucose decorated SLNs as compared to that seen with free MTX and SLNs-MTX. Fucose decorated SLNs showed promising results to develop therapeutic interventions for breast cancer, and paved a way to explore this promising and novel nano-carrier which enables to address breast cancer. PMID:27268228

  1. Fucose decorated solid-lipid nanocarriers mediate efficient delivery of methotrexate in breast cancer therapeutics.

    Science.gov (United States)

    Garg, Neeraj K; Singh, Bhupinder; Jain, Ashay; Nirbhavane, Pradip; Sharma, Rajeev; Tyagi, Rajeev K; Kushwah, Varun; Jain, Sanyog; Katare, Om Prakash

    2016-10-01

    The present study is designed to engineer fucose anchored methotrexate loaded solid lipid nanoparticles (SLNs) to target breast cancer. The developed nano-carriers were characterized with respect to particle size, PDI, zeta potential, drug loading and entrapment, in-vitro release etc. The characterized formulations were used to comparatively assess cellular uptake, cell-viability, apoptosis, lysosomal membrane permeability, bioavailability, biodistribution, changes in tumor volume and animal survival. The ex-vivo results showed greater cellular uptake and better cytotoxicity at lower IC50 of methotrexate in breast cancer cells. Further, we observed increased programmed cell death (apoptosis) with altered lysosomal membrane permeability and better rate of degradation of lysosomal membrane in-vitro. On the other hand, in-vivo evaluation showed maximum bioavailability and tumor targeting efficiency with minimum secondary drug distribution in various organs with formulated and anchored nano-carrier when compared with free drug. Moreover, sizeable reduction in tumor burden was estimated with fucose decorated SLNs as compared to that seen with free MTX and SLNs-MTX. Fucose decorated SLNs showed promising results to develop therapeutic interventions for breast cancer, and paved a way to explore this promising and novel nano-carrier which enables to address breast cancer.

  2. Sublime Views and Beautiful Explanations

    DEFF Research Database (Denmark)

    Barry, Daved; Meisiek, Stefan; Hatch, Mary Jo

    To create a generative theory that provides beautiful explanations and sublime views requires both a crafts and an art approach to scientific theorizing. The search for generativity leads scholars to perform various theorizing moves between the confines of simple, yet eloquent beauty...

  3. Escaping Beauty through moral narratives

    DEFF Research Database (Denmark)

    Sloth, Erik

    2010-01-01

    This study investigate through ethnographic studies the shared cultural meanings expressed about human beauty. How is sense making about the notion of beauty constructed, verballized and negotiated in a group of young females between 24 and 26 years old. Furthermore the study discuss and elaborate...

  4. 面部皮脂腺囊肿美容治疗64例疗效观察%Observation on Therapeutic Effect of Homemade Beauty Curette Treatment on Facial sebaceous Cyst of 64 Cases

    Institute of Scientific and Technical Information of China (English)

    伦杰; 张亚楠; 吕心红

    2013-01-01

    目的: 探讨应用自制美容刮匙治疗面部皮脂腺囊肿的方法和疗效。方法应用与自制美容刮匙相同直径的针头穿破皮脂腺囊肿,将囊内物质部分自行溢出,然后应用自制美容刮匙刮除干净,用庆大霉素冲洗,用眼科有齿镊尽可能把囊壁部分或全部夹出,再使用庆大霉素冲洗,轻度加压包扎。结果门诊选择的64例患者,进行6个月的随访,无复发及影响面容的52例,占84%;复发、影响了面容的22例,占16%。结论此方法从美容角度,特别对年轻人,瘢痕体质者,女性进行面部皮脂腺囊肿的门诊美容治疗,不做刀口手术,达到美容目的,是理想、可行的治疗,但是较手术切除容易复发。%Objective Reach and applications of the methods and curative effect of homemade beauty curette treatment of facial sebaceous cyst. Method Use the same diameter needle homemade beauty curette to piercesebaceous cyst, overflow the capsule material by itself, and then clean it by using homemade beauty curette, use gentamicin to clean it, and then useophthalmic toothed forceps clamp cyst wall as far as possible, then use gentamicin to clean it and pack it softly. Result Sampled 64 patients and after 6 months follow-up, 84%of which, 52 of them, no recurrence and no bad influence for face;16%of which, 22 of them, recurrence and bad influence for the face. Conclusion From cosmetic point of view, this method is an ideal sebaceous cyst treatment especially for young people, physical scars and female. But easy to relapse compared with surgical resection.

  5. Plant-Mediated Synthesis of Silver Nanoparticles: Their Characteristic Properties and Therapeutic Applications

    Science.gov (United States)

    Chung, Ill-Min; Park, Inmyoung; Seung-Hyun, Kim; Thiruvengadam, Muthu; Rajakumar, Govindasamy

    2016-01-01

    Interest in "green nanotechnology" in nanoparticle biosynthesis is growing among researchers. Nanotechnologies, due to their physicochemical and biological properties, have applications in diverse fields, including drug delivery, sensors, optoelectronics, and magnetic devices. This review focuses on the green synthesis of silver nanoparticles (AgNPs) using plant sources. Green synthesis of nanoparticles is an eco-friendly approach, which should be further explored for the potential of different plants to synthesize nanoparticles. The sizes of AgNPs are in the range of 1 to 100 nm. Characterization of synthesized nanoparticles is accomplished through UV spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, transmission electron microscopy, and scanning electron microscopy. AgNPs have great potential to act as antimicrobial agents. The green synthesis of AgNPs can be efficiently applied for future engineering and medical concerns. Different types of cancers can be treated and/or controlled by phytonanotechnology. The present review provides a comprehensive survey of plant-mediated synthesis of AgNPs with specific focus on their applications, e.g., antimicrobial, antioxidant, and anticancer activities.

  6. Plant-Mediated Synthesis of Silver Nanoparticles: Their Characteristic Properties and Therapeutic Applications.

    Science.gov (United States)

    Chung, Ill-Min; Park, Inmyoung; Seung-Hyun, Kim; Thiruvengadam, Muthu; Rajakumar, Govindasamy

    2016-12-01

    Interest in "green nanotechnology" in nanoparticle biosynthesis is growing among researchers. Nanotechnologies, due to their physicochemical and biological properties, have applications in diverse fields, including drug delivery, sensors, optoelectronics, and magnetic devices. This review focuses on the green synthesis of silver nanoparticles (AgNPs) using plant sources. Green synthesis of nanoparticles is an eco-friendly approach, which should be further explored for the potential of different plants to synthesize nanoparticles. The sizes of AgNPs are in the range of 1 to 100 nm. Characterization of synthesized nanoparticles is accomplished through UV spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, transmission electron microscopy, and scanning electron microscopy. AgNPs have great potential to act as antimicrobial agents. The green synthesis of AgNPs can be efficiently applied for future engineering and medical concerns. Different types of cancers can be treated and/or controlled by phytonanotechnology. The present review provides a comprehensive survey of plant-mediated synthesis of AgNPs with specific focus on their applications, e.g., antimicrobial, antioxidant, and anticancer activities. PMID:26821160

  7. CYP24 inhibition as a therapeutic target in FGF23-mediated renal phosphate wasting disorders.

    Science.gov (United States)

    Bai, Xiuying; Miao, Dengshun; Xiao, Sophia; Qiu, Dinghong; St-Arnaud, René; Petkovich, Martin; Gupta, Ajay; Goltzman, David; Karaplis, Andrew C

    2016-02-01

    CYP24A1 (hereafter referred to as CYP24) enzymatic activity is pivotal in the inactivation of vitamin D metabolites. Basal renal and extrarenal CYP24 is usually low but is highly induced by its substrate 1,25-dihydroxyvitamin D. Unbalanced high and/or long-lasting CYP24 expression has been proposed to underlie diseases like chronic kidney disease, cancers, and psoriasis that otherwise should favorably respond to supplemental vitamin D. Using genetically modified mice, we have shown that renal phosphate wasting hypophosphatemic states arising from high levels of fibroblast growth factor 23 (FGF23) are also associated with increased renal Cyp24 expression, suggesting that elevated CYP24 activity is pivotal to the pathophysiology of these disorders. We therefore crossed 2 mouse strains, each with distinct etiology for high levels of circulating FGF23, onto a Cyp24-null background. Specifically, we evaluated Cyp24 deficiency in Hyp mice, the murine homolog of X-linked dominant hypophosphatemic rickets, and transgenic mice that overexpress a mutant FGF23 (FGF23R176Q) that is associated with the autosomal dominant form of hypophosphatemic rickets. Loss of Cyp24 in these murine models of human disease resulted in near-complete recovery of rachitic/osteomalacic bony abnormalities in the absence of any improvement in the serum biochemical profile. Moreover, treatment of Hyp and FGF23R1760-transgenic mice with the CYP24 inhibitor CTA102 also ameliorated their rachitic bones. Our results link CYP24 activity to the pathophysiology of FGF23-dependent renal phosphate wasting states and implicate pharmacologic CYP24 inhibition as a therapeutic adjunct for their treatment. PMID:26784541

  8. Targeting hypoxia-mediated mucin 2 production as a therapeutic strategy for mucinous tumors.

    Science.gov (United States)

    Dilly, Ashok K; Lee, Yong J; Zeh, Herbert J; Guo, Zong Sheng; Bartlett, David L; Choudry, Haroon A

    2016-03-01

    Excessive accumulation of mucin 2 (MUC2; a gel-forming secreted mucin) protein in the peritoneal cavity is the major cause of morbidity and mortality in pseudomyxoma peritonei (PMP). Hypoxia (hypoxia-inducible factor-1α; HIF-1α) has been shown to regulate the expression of similar mucins (eg, MUC5AC). We hypothesized that hypoxia (HIF-1α) drives MUC2 expression in PMP and is therefore a novel target to reduce mucinous tumor growth. The regulation of MUC2 by 2% hypoxia (HIF-1α) was evaluated in MUC2-secreting LS174T cells. The effect of BAY 87-2243, an inhibitor of HIF-1α, on MUC2 expression and mucinous tumor growth was evaluated in LS174T cells, PMP explant tissue, and in a unique intraperitoneal murine xenograft model of PMP. In vitro exposure of LS174T cells to hypoxia increased MUC2 messenger RNA (mRNA) and protein expression and increased HIF-1α binding to the MUC2 promoter. Hypoxia-mediated MUC2 protein overexpression was downregulated by transfected HIF-1α small interfering RNA (siRNA) compared with scrambled siRNA in LS174T cells. BAY 87-2243 inhibited hypoxia-induced MUC2 mRNA and protein expression in LS174T cells and PMP explant tissue. In a murine xenograft model of PMP, chronic oral therapy with BAY 87-2243 inhibited mucinous tumor growth and MUC2, HIF-1α expression in the tumor tissue. Our data suggest that hypoxia (HIF-1α) induces MUC2 promoter activity to increase MUC2 expression. HIF-1α inhibition decreases MUC2 production and mucinous tumor growth, providing a preclinical rationale for the use of HIF-1α inhibitors to treat patients with PMP.

  9. Therapeutic targeting of myeloid-derived suppressor cells involves a novel mechanism mediated by clusterin.

    Science.gov (United States)

    Zhou, Junmin; Donatelli, Sarah S; Gilvary, Danielle L; Tejera, Melba M; Eksioglu, Erika A; Chen, Xianghong; Coppola, Domenico; Wei, Sheng; Djeu, Julie Y

    2016-01-01

    Myeloid-derived suppressor cells (MDSCs) constitute a key checkpoint that impedes tumor immunity against cancer. Chemotherapeutic intervention of MDSCs has gained ground as a strategy for cancer therapy but its mechanism remains obscure.We report here a unique mechanism by which monocytic (M)-MDSCs are spared, allowing them to polarize towards M1 macrophages for reactivation of immunity against breast cancer. We first demonstrated that curcumin, like docetaxel (DTX), can selectively target CD11b(+)Ly6G(+)Ly6C(low) granulocytic (G)-MDSCs, sparing CD11b(+)Ly6G(-)Ly6C(high) M-MDSCs, with reduced tumor burden in 4T1-Neu tumor-bearing mice. Curcumin treatment polarized surviving M-MDSCs toward CCR7(+) Dectin-1(-)M1 cells, accompanied by IFN-γ production and cytolytic function in T cells. Selective M-MDSC chemoresistence to curcumin and DTX was mediated by secretory/cytoplasmic clusterin (sCLU). sCLU functions by trapping Bax from mitochondrial translocation, preventing the apoptotic cascade. Importantly, sCLU was only found in M-MDSCs but not in G-MDSCs. Knockdown of sCLU in M-MDSCs and RAW264.7 macrophages was found to reverse their natural chemoresistance. Clinically, breast cancer patients possess sCLU expression only in mature CD68(+) macrophages but not in immature CD33(+) immunosuppressive myeloid cells infiltrating the tumors. We thus made the seminal discovery that sCLU expression in M-MDSCs accounts for positive immunomodulation by chemotherapeutic agents. PMID:27405665

  10. Therapeutic targeting of myeloid-derived suppressor cells involves a novel mechanism mediated by clusterin

    Science.gov (United States)

    Zhou, Junmin; Donatelli, Sarah S.; Gilvary, Danielle L.; Tejera, Melba M.; Eksioglu, Erika A.; Chen, Xianghong; Coppola, Domenico; Wei, Sheng; Djeu, Julie Y.

    2016-01-01

    Myeloid-derived suppressor cells (MDSCs) constitute a key checkpoint that impedes tumor immunity against cancer. Chemotherapeutic intervention of MDSCs has gained ground as a strategy for cancer therapy but its mechanism remains obscure.We report here a unique mechanism by which monocytic (M)-MDSCs are spared, allowing them to polarize towards M1 macrophages for reactivation of immunity against breast cancer. We first demonstrated that curcumin, like docetaxel (DTX), can selectively target CD11b+Ly6G+Ly6Clow granulocytic (G)-MDSCs, sparing CD11b+Ly6G−Ly6Chigh M-MDSCs, with reduced tumor burden in 4T1-Neu tumor-bearing mice. Curcumin treatment polarized surviving M-MDSCs toward CCR7+ Dectin-1−M1 cells, accompanied by IFN-γ production and cytolytic function in T cells. Selective M-MDSC chemoresistence to curcumin and DTX was mediated by secretory/cytoplasmic clusterin (sCLU). sCLU functions by trapping Bax from mitochondrial translocation, preventing the apoptotic cascade. Importantly, sCLU was only found in M-MDSCs but not in G-MDSCs. Knockdown of sCLU in M-MDSCs and RAW264.7 macrophages was found to reverse their natural chemoresistance. Clinically, breast cancer patients possess sCLU expression only in mature CD68+ macrophages but not in immature CD33+ immunosuppressive myeloid cells infiltrating the tumors. We thus made the seminal discovery that sCLU expression in M-MDSCs accounts for positive immunomodulation by chemotherapeutic agents. PMID:27405665

  11. BEAUTIFUL, SENSE OF BEAUTY AND ELEMENTS OF BEAUTY IN TURKISH “MÂNİ”

    Directory of Open Access Journals (Sweden)

    Bülent Kahraman Çolakoğlu

    2014-08-01

    Full Text Available This study underlines the “mâni” which represents anonymous folk literature reflecting Turkish cultural life. Turkish nation’s sense of beautiful and beauty, the elements of beauty which belong to beauty/beloved have been studied with reference to Turkish “mâni” in order to protect Turkish cultural treasures and ensure them to be inherited from generation to generation by functionalizing them. In the study, content analysis has been used in the process of data interpretation. 4068 “mâni”s which are in the source tagged with “Demir, Necati (2013, Türk Mânileri, Ankara: Gazi Kitabevi” have been examined and they have been analyzed and assessed in line with the predetermined purpose. With this study, it is consolidated that the Turks have always had advanced sense of beauty; they have always been a nation who has a taste for beauty and taste and sense of aesthetic since the old historical periods. It is observed that the poetic themes of hair, eyebrow, eyelash, eye, beauty spot, cheek-dimple, face, cheek-dewlap, waist, heel, skin, age, speech, smile, smell, jewellery/ornament, deportment, coquetry/manner/affection are used as elements of beauty in Turkish “mâni”.

  12. Is better beautiful or is beautiful better? Exploring the relationship between beauty and category structure.

    Science.gov (United States)

    Sanders, Megan; Davis, Tyler; Love, Bradley C

    2013-06-01

    We evaluate two competing accounts of the relationship between beauty and category structure. According to the similarity-based view, beauty arises from category structure such that central items are favored due to their increased fluency. In contrast, the theory-based view holds that people's theories of beauty shape their perceptions of categories. In the present study, subjects learned to categorize abstract paintings into meaningfully labeled categories and rated the paintings' beauty, value, and typicality. Inconsistent with the similarity-based view, beauty ratings were highly correlated across conditions despite differences in fluency and assigned category structure. Consistent with the theory-based view, beautiful paintings were treated as central members for categories expected to contain beautiful paintings (e.g., art museum pieces), but not in others (e.g., student show pieces). These results suggest that the beauty of complex, real-world stimuli is not determined by fluency within category structure but, instead, interacts with people's prior knowledge to structure categories. PMID:23242799

  13. Dextrose-mediated aggregation of therapeutic monoclonal antibodies in human plasma: Implication of isoelectric precipitation of complement proteins.

    Science.gov (United States)

    Luo, Shen; Zhang, Baolin

    2015-01-01

    Many therapeutic monoclonal antibodies (mAbs) are clinically administered through intravenous infusion after mixing with a diluent, e.g., saline, 5% dextrose. Such a clinical setting increases the likelihood of interactions among mAb molecules, diluent, and plasma components, which may adversely affect product safety and efficacy. Avastin® (bevacizumab) and Herceptin® (trastuzumab), but not Remicade® (infliximab), were shown to undergo rapid aggregation upon dilution into 5% dextrose when mixed with human plasma in vitro; however, the biochemical pathways leading to the aggregation were not clearly defined. Here, we show that dextrose-mediated aggregation of Avastin or Herceptin in plasma involves isoelectric precipitation of complement proteins. Using mass spectrometry, we found that dextrose-induced insoluble aggregates were composed of mAb itself and multiple abundant plasma proteins, namely complement proteins C3, C4, factor H, fibronectin, and apolipoprotein. These plasma proteins, which are characterized by an isoelectronic point of 5.5-6.7, lost solubility at the resulting pH in the mixture with formulated Avastin (pH 6.2) and Herceptin (pH 6.0). Notably, switching formulation buffers for Avastin (pH 6.2) and Remicade (pH 7.2) reversed their aggregation profiles. Avastin formed little, if any, insoluble aggregates in dextrose-plasma upon raising the buffer pH to 7.2 or above. Furthermore, dextrose induced pH-dependent precipitation of plasma proteins, with massive insoluble aggregates being detected at pH 6.5-6.8. These data show that isoelectric precipitation of complement proteins is a prerequisite of dextrose-induced aggregation of mAb in human plasma. This finding highlights the importance of assessing the compatibility of a therapeutic mAb with diluent and human plasma during product development. PMID:26338058

  14. Dextrose-mediated aggregation of therapeutic monoclonal antibodies in human plasma: Implication of isoelectric precipitation of complement proteins.

    Science.gov (United States)

    Luo, Shen; Zhang, Baolin

    2015-01-01

    Many therapeutic monoclonal antibodies (mAbs) are clinically administered through intravenous infusion after mixing with a diluent, e.g., saline, 5% dextrose. Such a clinical setting increases the likelihood of interactions among mAb molecules, diluent, and plasma components, which may adversely affect product safety and efficacy. Avastin® (bevacizumab) and Herceptin® (trastuzumab), but not Remicade® (infliximab), were shown to undergo rapid aggregation upon dilution into 5% dextrose when mixed with human plasma in vitro; however, the biochemical pathways leading to the aggregation were not clearly defined. Here, we show that dextrose-mediated aggregation of Avastin or Herceptin in plasma involves isoelectric precipitation of complement proteins. Using mass spectrometry, we found that dextrose-induced insoluble aggregates were composed of mAb itself and multiple abundant plasma proteins, namely complement proteins C3, C4, factor H, fibronectin, and apolipoprotein. These plasma proteins, which are characterized by an isoelectronic point of 5.5-6.7, lost solubility at the resulting pH in the mixture with formulated Avastin (pH 6.2) and Herceptin (pH 6.0). Notably, switching formulation buffers for Avastin (pH 6.2) and Remicade (pH 7.2) reversed their aggregation profiles. Avastin formed little, if any, insoluble aggregates in dextrose-plasma upon raising the buffer pH to 7.2 or above. Furthermore, dextrose induced pH-dependent precipitation of plasma proteins, with massive insoluble aggregates being detected at pH 6.5-6.8. These data show that isoelectric precipitation of complement proteins is a prerequisite of dextrose-induced aggregation of mAb in human plasma. This finding highlights the importance of assessing the compatibility of a therapeutic mAb with diluent and human plasma during product development.

  15. Role of LPS/CD14/TLR4-mediated inflammation in necrotizing enterocolitis: Pathogenesis and therapeutic implications

    Institute of Scientific and Technical Information of China (English)

    Kwong L Chan; Kwong F Wong; John M Luk

    2009-01-01

    AIM: To establish the roles of lipopolysaccharide (LPS)/CD14/toll-like receptor 4 (TLR4)-mediated inflammation in a rat model of human necrotizing enterocolitis (NEC). METHODS: Six pairs of intestinal samples from human NEC were collected before and after recovery for histological and molecular analysis of inflammatory cytokines and signaling components. In the rat NEC model, we isolated 10-cm jejunum segments and divided them into six groups ( n = 6) for sham operation, treatment with LPS, bowel distension, combined bowel distension and LPS stimulation, and two therapeutic groups. The potential efficacy of a recombinant CD18 peptide and a monoclonal CD14 antibody was evaluated in the latter two groups. The serum and tissue levels of several inflammatory mediators were quantified by real-time polymerase chain reaction, ELISA and immunoblotting. RESULTS: Human acute phase NEC tissues displayed significant increases ( P < 0.05) in levels of TLR4, CD14, myeloid differentiation protein (MD)-2, tumor necrosis factor (TNF)-α and nuclear factor-κB when compared to those after recovery. The histological and inflammatory picture of human NEC was reproduced in rats that were treated with combined bowel distension and LPS, but not in the sham-operated and other control rats. Serum levels of interleukin-6 and TNF-α were also elevated. The NEC pathology was attenuated by treating the NEC rats with a monoclonal CD14 antibody or an LPS-neutralizing peptide. CONCLUSION: LPS and distension are required to produce the histological and inflammatory features of NEC. A potential treatment option is blocking LPS activation and leukocyte infiltration.

  16. Symmetry and Beauty in Plato

    OpenAIRE

    Lloyd, David R.

    2010-01-01

    Plato writes about Beauty in many of his dialogues, particularly in the Symposium, but he has no word equivalent to our "Symmetry", and this concept was not then formalised. Nevertheless, there are indications that some aspects of the concept were understood, if only intuitively. Plato has a very abstract concept of beauty, and when he uses "beauty" to characterise the so-called "Platonic Solids" in the Timaeus, he seems to be emphasising at least their regularity. It can be argued that the w...

  17. Beauty and Astrophysics

    Science.gov (United States)

    Bessell, Michael S.

    2000-08-01

    Spectacular colour images have been made by combining CCD images in three different passbands using Adobe Photoshop. These beautiful images highlight a variety of astrophysical phenomena and should be a valuable resource for science education and public awareness of science. The wide field images were obtained at the Siding Spring Observatory (SSO) by mounting a Hasselblad or Nikkor telephoto lens in front of a 2K × 2K CCD. Options of more than 30 degrees or 6 degrees square coverage are produced in a single exposure in this way. Narrow band or broad band filters were placed between lens and CCD enabling deep, linear images in a variety of passbands to be obtained. We have mapped the LMC and SMC and are mapping the Galactic Plane for comparison with the Molonglo Radio Survey. Higher resolution images have also been made with the 40 inch telescope of galaxies and star forming regions in the Milky Way.

  18. Beauty Or Health? A Personal View

    OpenAIRE

    Riji, Haliza Mohd

    2006-01-01

    This paper deals with the question of beauty and health in women. It discusses changing definitions of beauty as a result of influences from the entertainment, beauty and health product industries. Advertisements are seen to be major players in defining beauty through promotion of cosmetic, skin, hair and slimming products. Concerns relating to beauty become inculcated in girls through the process of socialisation as they mature into womanhood. The media plays a significant role in portraying...

  19. Taxi Drivers and Beauty Contests

    OpenAIRE

    Camerer, Colin F

    1997-01-01

    The trading floor of the New York Stock Exchange. The British economist John Maynard Keynes likened playing the market to voting for the prettiest face in a beauty contest; hence the second part of this article’s title.

  20. Success: Talent, Intelligence or Beauty?

    OpenAIRE

    Gergaud, Olivier; GINSBURGH, Victor

    2010-01-01

    We analyze the Celebrity 100 annual list of the world’s most “powerful celebrities” compiled and published by Forbes Magazine. The lists provide an interesting collection of people, that includes their earnings, and the perception of citizens concerning the attributes that made them become celebrities. We analyze the relationship between their earnings and the perceptions on their intelligence, talent, beauty and other attributes, and show that though beauty plays a role, intelligence and tal...

  1. Beauty and Health: Anthropological Perspectives

    OpenAIRE

    Edmonds, Alexander

    2008-01-01

    This essay, written as a ‘teaser’ for an up-coming symposium, reflects on how human beauty can be understood from an anthropological and medical anthropological perspective. First, it considers how aesthetic and healing rationales can conflict or merge in a variety of medical technologies and health practices. Second, it discusses beauty in relation to the socioeconomic transformations of modernity and globalization. It suggests the need for a theoretical framework that departs from a strictl...

  2. THE BEAUTY AND THE SUBLIME

    OpenAIRE

    Bárbara Maria Brandão Guatimosim

    2008-01-01

    The text approaches the beauty and the sublime under the perspective of its intersections and of its function as barrier (the beauty), and as path to the reaching of desire (the sublime). From the kantian contribution to the notion of the Sublime along with the anxiety affect witch characterizes it, the concept of sublimation can be taken as a form of well saying, witch participates of a tragic-baroque esthetic, according with an impure desire ethic. Thereafter the text approaches the consequ...

  3. Beauty Or Health? A Personal View.

    Science.gov (United States)

    Riji, Haliza Mohd

    2006-01-01

    This paper deals with the question of beauty and health in women. It discusses changing definitions of beauty as a result of influences from the entertainment, beauty and health product industries. Advertisements are seen to be major players in defining beauty through promotion of cosmetic, skin, hair and slimming products. Concerns relating to beauty become inculcated in girls through the process of socialisation as they mature into womanhood. The media plays a significant role in portraying the meaning of beauty through its representation of women. These influences largely influence and alter women's perceptions of their body image and in trying to meet the goals of beauty as represented by the media. This may result in dissatisfaction with their body image. Advertisements can encourage women to indulge in smoking as a fashionable trend or opt for plastic surgery in attempts to acquire beauty. This paper concludes with implications of the issues relating to changing perceptions of beauty and suggests recommendations. PMID:26998213

  4. A trigger for beauty

    International Nuclear Information System (INIS)

    The possibility of B-meson experiments, in a fixed-target high-energy proton machine (Tevatron) is discussed. Compared to a B-meson factory experiment, it can produce 105, Banti B's per hour, using 108 protons per second, but it suffers from high background and needs high selectivity to cope with the million times higher interaction rate. To overcome these difficulties a technique called the 'optical trigger for beauty' is proposed, based on the detection of Cherenkov photons produced in a 2 mm thick LiF crystal, through a fast photodetector. Its virtue is that it is opaque to minimum-bias events originating in a small target, but sensitive to the high impact parameter B-meson decay charged particles from a secondary vertex. Calculations and first simulations results give a good efficiency for B-meson detection. A multistep trigger, combining the 'optical trigger' and a tracking detector, allows significant selection and a consequent enrichment of the data sample. Taking into account its fast response (∝ 1 ns), the above considerations can be extended to other hadronic machines, especially those with high-rate environments such as the LHC or SSC. (orig.)

  5. She Looks so Beautiful

    Directory of Open Access Journals (Sweden)

    Karen de Kock

    2008-07-01

    Full Text Available This article offers a story that illustrates how the medium of music is able to provide comfort, even in extreme cases of hopelessness, when all other efforts seem futile. I will relate how the creative act of music-making within an institutional setting, was able to provide comfort to a self-injurious female psychiatric client, who had been institutionalised all her life, to restore a sense of beauty and dignity which had been lost. The music that was created in the moment was also able to carry and support all the individuals who were creating it - even in the most desperate moments where those that were supposed to be "in command" were experiencing a sense of uncertainty. The story further demonstrates how a client, a care-worker and a therapist, three individuals from very diverse backgrounds and life circumstances, were able to transcend their different histories to come together and connect on a level which they have not been able to do outside the music therapy room.

  6. Therapeutic benefit of lentiviral-mediated neonatal intracerebral gene therapy in a mouse model of globoid cell leukodystrophy.

    Science.gov (United States)

    Lattanzi, Annalisa; Salvagno, Camilla; Maderna, Claudio; Benedicenti, Fabrizio; Morena, Francesco; Kulik, Willem; Naldini, Luigi; Montini, Eugenio; Martino, Sabata; Gritti, Angela

    2014-06-15

    Globoid cell leukodystrophy (GLD) is an inherited lysosomal storage disease caused by β-galactocerebrosidase (GALC) deficiency. Gene therapy (GT) should provide rapid, extensive and lifetime GALC supply in central nervous system (CNS) tissues to prevent or halt irreversible neurologic progression. Here we used a lentiviral vector (LV) to transfer a functional GALC gene in the brain of Twitcher mice, a severe GLD model. A single injection of LV.GALC in the external capsule of Twitcher neonates resulted in robust transduction of neural cells with minimal and transient activation of inflammatory and immune response. Importantly, we documented a proficient transduction of proliferating and post-mitotic oligodendroglia, a relevant target cell type in GLD. GALC activity (30-50% of physiological levels) was restored in the whole CNS of treated mice as early as 8 days post-injection. The early and stable enzymatic supply ensured partial clearance of storage and reduction of psychosine levels, translating in amelioration of histopathology and enhanced lifespan. At 6 months post-injection in non-affected mice, LV genome persisted exclusively in the injected region, where transduced cells overexpressed GALC. Integration site analysis in transduced brain tissues showed no aberrant clonal expansion and preferential targeting of neural-specific genes. This study establishes neonatal LV-mediated intracerebral GT as a rapid, effective and safe therapeutic intervention to correct CNS pathology in GLD and provides a strong rationale for its application in this and similar leukodystrophies, alone or in combination with therapies targeting the somatic pathology, with the final aim of providing an effective and timely treatment of these global disorders.

  7. Lipid raft-mediated Fas/CD95 apoptotic signaling in leukemic cells and normal leukocytes and therapeutic implications.

    Science.gov (United States)

    Gajate, Consuelo; Mollinedo, Faustino

    2015-11-01

    Plasma membrane is now recognized to contain tightly packed cholesterol/sphingolipid-rich domains, known as lipid or membrane rafts, which are more ordered than the surrounding lipid bilayer. Lipid rafts are crucial for the compartmentalization of signaling processes in the membrane, mostly involved in cell survival and immune response. However, in the last 15 years, a large body of evidence has also identified raft platforms as scaffolds for the recruitment and clustering of death receptor Fas/CD95 and downstream signaling molecules, leading to the concept of death-promoting lipid rafts. This raft-Fas/CD95 coclustering was first described at the early 2000s as the underlying mechanism for the proapoptotic action of the alkylphospholipid analog edelfosine in leukemic cells, hence facilitating protein-protein interactions and conveying apoptotic signals independently of Fas/CD95 ligand. Edelfosine induces apoptosis in hematologic cancer cells and activated T-lymphocytes. Fas/CD95 raft coclustering is also promoted by Fas/CD95 ligand, agonistic Fas/CD95 antibodies, and additional antitumor drugs. Thus, death receptor recruitment in rafts is a physiologic process leading to cell demise that can be pharmacologically modulated. This redistribution and local accumulation of apoptotic molecules in membrane rafts, which are usually accompanied by displacement of survival signaling molecules, highlight how alterations in the apoptosis/survival signaling balance in specialized membrane regions modulate cell fate. Membrane rafts might also modulate apoptotic and nonapoptotic death receptor signaling. Here, we discuss the role of lipid rafts in Fas/CD95-mediated apoptotic cell signaling in hematologic cancer cells and normal leukocytes, with a special emphasis on their involvement as putative therapeutic targets in cancer and autoimmune diseases.

  8. Flow-mediated vasodilation as a predictor of therapeutic response to midodrine hydrochloride in children with postural orthostatic tachycardia syndrome.

    Science.gov (United States)

    Liao, Ying; Yang, Jinyan; Zhang, Fengwen; Chen, Stella; Liu, Xueqin; Zhang, Qingyou; Ai, Yi; Wang, Yuli; Tang, Chaoshu; Du, Junbao; Jin, Hongfang

    2013-09-15

    This study was designed to explore the value of flow-mediated vasodilation (FMD) as a predictor of therapeutic response to midodrine hydrochloride (MD) in children with postural orthostatic tachycardia syndrome (POTS). One hundred and eight children diagnosed with POTS and 20 healthy control children were enrolled. All children with POTS received MD and were followed up for 3 months. FMD of brachial artery for each participant was measured by vascular ultrasound. Symptom scores, FMD values, and head-up test (HUT)/head-up tilt test (HUTT) outcomes were investigated before and after treatment. A receiver operating characteristic curve was used to explore the value of FMD as a predictor. Baseline FMD (%) and increased heart rate (beats per minute) during HUT/HUTT were significantly greater in children with POTS compared with control children (FMD: 11 ± 3% vs 6 ± 2%, p <0.001; increased heart rate: 38 ± 9 vs 7 ± 7 beats/min, p <0.001, respectively). Before treatment, MD responders had greater FMD values than MD nonresponders (p <0.05). Symptom scores, excessive increases in heart rate during HUT, and increased FMD values were all reduced significantly after treatment (all p <0.05). The receiver operating characteristic curve for the predictive value of FMD showed the area under the curve to be 0.790 (95% confidence interval: 0.679 to 0.902; p <0.001) at 1-month and 0.803 (95% confidence interval: 0.669 to 0.936; p <0.01) at 3-month therapy. FMD of 9.85% had a high sensitivity (1-month therapy: 71.6%; 3-month therapy: 74.4%) and specificity (1-month therapy 77.8%; 3-month therapy: 80%). In conclusion, FMD is a predictor of the efficacy of MD for treating children with POTS.

  9. Phenylbutyrate counteracts Shigella mediated downregulation of cathelicidin in rabbit lung and intestinal epithelia: a potential therapeutic strategy.

    Directory of Open Access Journals (Sweden)

    Protim Sarker

    Full Text Available BACKGROUND: Cathelicidins and defensins are endogenous antimicrobial peptides (AMPs that are downregulated in the mucosal epithelia of the large intestine in shigellosis. Oral treatment of Shigella infected rabbits with sodium butyrate (NaB reduces clinical severity and counteracts the downregulation of cathelicidin (CAP-18 in the large intestinal epithelia. AIMS: To develop novel regimen for treating infectious diseases by inducing innate immunity, we selected sodium 4-phenylbutyrate (PB, a registered drug for a metabolic disorder as a potential therapeutic candidate in a rabbit model of shigellosis. Since acute respiratory infections often cause secondary complications during shigellosis, the systemic effect of PB and NaB on CAP-18 expression in respiratory epithelia was also evaluated. METHODS: The readouts were clinical outcomes, CAP-18 expression in mucosa of colon, rectum, lung and trachea (immunohistochemistry and real-time PCR and release of the CAP-18 peptide/protein in stool (Western blot. PRINCIPAL FINDINGS: Significant downregulation of CAP-18 expression in the epithelia of rectum and colon, the site of Shigella infection was confirmed. Interestingly, reduced expression of CAP-18 was also noticed in the epithelia of lung and trachea, indicating a systemic effect of the infection. This suggests a causative link to acute respiratory infections during shigellosis. Oral treatment with PB resulted in reduced clinical illness and upregulation of CAP-18 in the epithelium of rectum. Both PB and NaB counteracted the downregulation of CAP-18 in lung epithelium. The drug effect is suggested to be systemic as intravenous administration of NaB could also upregulate CAP-18 in the epithelia of lung, rectum and colon. CONCLUSION: Our results suggest that PB has treatment potential in human shigellosis. Enhancement of CAP-18 in the mucosal epithelia of the respiratory tract by PB or NaB is a novel discovery. This could mediate protection from

  10. The golden beauty: brain response to classical and renaissance sculptures.

    Science.gov (United States)

    Di Dio, Cinzia; Macaluso, Emiliano; Rizzolatti, Giacomo

    2007-01-01

    Is there an objective, biological basis for the experience of beauty in art? Or is aesthetic experience entirely subjective? Using fMRI technique, we addressed this question by presenting viewers, naïve to art criticism, with images of masterpieces of Classical and Renaissance sculpture. Employing proportion as the independent variable, we produced two sets of stimuli: one composed of images of original sculptures; the other of a modified version of the same images. The stimuli were presented in three conditions: observation, aesthetic judgment, and proportion judgment. In the observation condition, the viewers were required to observe the images with the same mind-set as if they were in a museum. In the other two conditions they were required to give an aesthetic or proportion judgment on the same images. Two types of analyses were carried out: one which contrasted brain response to the canonical and the modified sculptures, and one which contrasted beautiful vs. ugly sculptures as judged by each volunteer. The most striking result was that the observation of original sculptures, relative to the modified ones, produced activation of the right insula as well as of some lateral and medial cortical areas (lateral occipital gyrus, precuneus and prefrontal areas). The activation of the insula was particularly strong during the observation condition. Most interestingly, when volunteers were required to give an overt aesthetic judgment, the images judged as beautiful selectively activated the right amygdala, relative to those judged as ugly. We conclude that, in observers naïve to art criticism, the sense of beauty is mediated by two non-mutually exclusive processes: one based on a joint activation of sets of cortical neurons, triggered by parameters intrinsic to the stimuli, and the insula (objective beauty); the other based on the activation of the amygdala, driven by one's own emotional experiences (subjective beauty).

  11. Cycles of Beauty Culture: Ethnography of Beauty Clinics Commodification

    Directory of Open Access Journals (Sweden)

    Sri Murlianti

    2014-12-01

    Full Text Available Skin care is not a completely new in beauty treatments. Previously there have been other types of cultural industry which also adopted the medical science, such as cosmetic and beauty salon industries. But, skin care beauty clinic successfully introduces the services of beauty treatments which are considered the healthiest. This paper is a summary of the research on how beauty clinic quickly became a part of everyday life of its consumers. The research focused on Natasha Skin Care, a most popular beauty clinic in Indonesia at the moment. According to Richard Johnson, the process of a culture industry reaches the society through a communication that in form a pattern cyclic communications. The stages in the pattern are interconnected but slipped, each stage is affecting others but are not specified in an uncertain manner; between the producer of culture industry with its consumers. This study is a multidiscipline research using three methods of interpretation namely ethnography, discourses analysis, and social hermeneutic study.Klinik kecantikan bukanlah budaya yang benar-benar baru dalam perawatan kecantikan. Sebelumnya telah ada jenis industri budaya lain yang juga mengadopsi ilmu kedokteran, seperti industri kosmetik dan salon kecantikan. Namun klinik kecantikan sukses menyandang predikat sebagai jasa perawatan kecantikan yang dianggap paling sehat. Tulisan ini merupakan rigkasan penelitian tentang bagaimana klinik kecantikan begitu cepat menjadi bagian hidup sehari–hari masyarakat konsumennya. Fokus penelitian ini adalah Natasha Skin Care, sebuah klinik kecantikan paling popular di Indonesia saat ini. Menurut Richard Johson proses sebuah industri budaya sampai pada masyarakat konsumennya melalui komunikasi yang timpang, membentuk pola komunikasi siklik, saling terhubung namun penuh dengan keterpelesetan, saling mewarnai namun tidak menentukan secara pasti antara produsen industri budaya dengan masyarakat konsumennya. Penelitian ini ditempuh

  12. Pluronic® L64-mediated stable HIF-1α expression in muscle for therapeutic angiogenesis in mouse hindlimb ischemia

    OpenAIRE

    Song, Hongmei; Liu, Sijia; Li, Caixia; Geng, Yanyan; Wang, Gang; Gu, Zhongwei

    2014-01-01

    Intramuscular injection of plasmid DNA (pDNA) to express a therapeutic protein is a promising method for the treatment of many diseases. However, the therapeutic applications are usually hindered by gene delivery efficiency and expression level. In this study, critical factors in a pDNA-based gene therapy system, such as gene delivery materials, a therapeutic gene, and its regulatory elements, were optimized to establish an integrated system for the treatment of mouse hindlimb ischemia. The r...

  13. Sleeping Beauties in Meme Diffusion

    CERN Document Server

    Zhang, Leihan; Xu, Ke

    2016-01-01

    A sleeping beauty in diffusion indicates that the information, can be ideas or innovations, will experience a hibernation before a sudden spike of popularity and it is widely found in citation history of scientific publications. However, in this study, we demonstrate that the sleeping beauty is an universal phenomenon in information diffusion and even more inspiring, there exist two consecutive sleeping beauties in the entire lifetime of propagation, suggesting that the information, including trending topics, search queries or Wikipedia views, which we call memes, will go unnoticed for a period and suddenly attracts some attention, and then it falls asleep again and later wakes up with another unexpected popularity peak. Further explorations on this phenomenon show that intervals between two wake ups follow an exponential distribution and the second awakening stage generally reaches its peak at a higher velocity and will bring a wider dissemination. Taking these findings into consideration, the upgraded Bass ...

  14. Beauty and brains don't mix?

    OpenAIRE

    Fallesen, Krista Bjerknæs; Schultz, Astrid Andrea; Nielsen, Christine Strube; Hansen, Sandra Springborg

    2014-01-01

    This project revolves around beautiful people. There do not exist a recipe for having a beautiful appearance, but we are from childhood as individuals 'coded' to recognize what is beautiful. This project is based on the fact that beautiful people are assigned values that they do not necessarily possess. These values will be described through Pierre Bourdieu's theory about capital and habitus. Some values will be examined especially in relation to one's job situation. Today's labor market will...

  15. Two beautiful proofs of Pick's theorem

    OpenAIRE

    Raman Sundström, Manya; Öhman, Lars-Daniel

    2011-01-01

    We present two different proofs of Pick’s theorem and analyse in what ways might be perceived as beautiful by working mathematicians. In particular, we discuss two concepts, generality and specificity, that appear to contribute to beauty in different ways. We also discuss possible implications on insight into the nature of beauty in mathematics, and how the teaching of mathematics could be impacted, especially in countries in which discussions of beauty and aesthetics are notably absent from...

  16. The Staunch Beauty of Flowers

    Institute of Scientific and Technical Information of China (English)

    1998-01-01

    MANY women like to collect dried flowers. Unable to bear the sight of beautiful blossoms withering, they press them between the leaves of books. As time passes, the original fresh flowers turn into thin pale-colored specimens, but a careful viewer will notice that they have taken on a new grace—just like Ren Jie herself; though no longer young, she has managed to create beauty out of her later life. Ren Jie’s love of flowers dates back to her childhood, when she started to collect flower specimens. As she grew up, she learned how to paint; later, she

  17. All things bright and beautiful

    OpenAIRE

    Brown, Chloe

    2012-01-01

    'All Things Bright and Beautiful' was exhibited in 20/21 Visual Arts Centre, Scunthorpe, which is sited in a 'redundant' church. The fundamental question that the exhibition explored concerned the role of 'the animal' within contemporary art and within secular society, which in turn hoped to prompt reflections on our understanding of the place of 'the human' in the world and in nature. If there is no divine order, as posited by the hymn 'All Things Bright and Beautiful', where does this leave...

  18. Performance of Pain, Performance of Beauty

    Science.gov (United States)

    Thompson, James

    2006-01-01

    "Performance of pain, performance of beauty" explores performance projects in war zones using Elaine Scarry's definitions of "pain" and "beauty" as a starting point. The way in which pain constricts the body and the experience that beauty can take a person beyond the body become a contested framework for considering two examples of performance.…

  19. Sex, beauty and the orbitofrontal cortex.

    Science.gov (United States)

    Ishai, Alumit

    2007-02-01

    Face perception is mediated by a distributed neural system in the human brain. Attention, memory and emotion modulate the neural activation evoked by faces, however the effects of gender and sexual orientation are currently unknown. To test whether subjects would respond more to their sexually-preferred faces, we scanned 40 hetero- and homosexual men and women whilst they assessed facial attractiveness. Behaviorally, regardless of their gender and sexual orientation, all subjects similarly rated the attractiveness of both male and female faces. Consistent with our hypothesis, a three-way interaction between stimulus gender, beauty and the sexual preference of the subject was found in the medial orbitofrontal cortex (OFC). In heterosexual women and homosexual men, attractive male faces elicited stronger activation than attractive female faces, whereas in heterosexual men and homosexual women, attractive female faces evoked stronger activation than attractive male faces. These findings suggest that the OFC represents the value of salient sexually-relevant faces, irrespective of their reproductive fitness.

  20. Computers, pattern, chaos and beauty

    CERN Document Server

    Pickover, Clifford A

    1980-01-01

    Combining fractal theory with computer art, this book introduces a creative use of computers. It describes graphic methods for detecting patterns in complicated data and illustrates simple techniques for visualizing chaotic behavior. ""Beautiful."" - Martin Gardner, Scientific American. Over 275 illustrations, 29 in color.

  1. Beauty Products and the Consumer.

    Science.gov (United States)

    New York State Education Dept., Albany. Bureau of Secondary Curriculum Development.

    GRADES OR AGES: High school. SUBJECT MATTER: Consumer education especially as it concerns the consumer's desire for beauty. Included are considerations of cosmetics, health spas, reducing salons, wigs, and jewelry. ORGANIZATION AND PHYSICAL APPEARANCE: The guide is discursively organized through the topics listed above. The physical appearance of…

  2. Quantum Beauty: Real and Ideal

    International Nuclear Information System (INIS)

    Does the world embody beautiful ideas? Pythagoras and Plato intuited that it should; Newton and Maxwell demonstrated how it could. But modern physics, and especially the quantum physics at its foundation, answers with a much more resounding and definitive 'Yes' I'll bring in history and art, as well as science, to make the case.(author)

  3. Beautiful Science: Worth a Visit

    Science.gov (United States)

    Bingham, Frederick M.

    2013-01-01

    For those in the profession of teaching physics who reside in or plan to visit the Los Angeles area, I would highly recommend a trip to the Huntington Library in San Marino, specifically to a permanent exhibit entitled "Beautiful Science: Ideas that Changed the World" in the Dibner Hall of the History of Science. The exhibit contains original…

  4. Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells.

    Science.gov (United States)

    Valente, Liz J; Aubrey, Brandon J; Herold, Marco J; Kelly, Gemma L; Happo, Lina; Scott, Clare L; Newbold, Andrea; Johnstone, Ricky W; Huang, David C S; Vassilev, Lyubomir T; Strasser, Andreas

    2016-03-01

    Nutlin3a is a small-molecule antagonist of MDM2 that promotes non-genotoxic activation of p53 through p53 protein stabilization and transactivation of p53 target genes. Nutlin3a is the forerunner of a class of cancer therapeutics that have reached clinical trials. Using transgenic and gene-targeted mouse models lacking the critical p53 target genes, p21, Puma, and Noxa, we found that only loss of PUMA conferred profound protection against Nutlin3a-induced killing in both non-transformed lymphoid cells and Eμ-Myc lymphomas in vitro and in vivo. CRISPR/Cas9-mediated targeting of the PUMA gene rendered human hematopoietic cancer cell lines markedly resistant to Nutlin3a-induced cell death. These results demonstrate that PUMA-mediated apoptosis, but not p21-mediated cell-cycle arrest or senescence, is a critical determinant of the therapeutic response to non-genotoxic p53 activation by Nutlin3a. Importantly, in human cancer, PUMA expression may predict patient responses to treatment with MDM2 antagonists. PMID:26904937

  5. Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells

    Directory of Open Access Journals (Sweden)

    Liz J. Valente

    2016-03-01

    Full Text Available Nutlin3a is a small-molecule antagonist of MDM2 that promotes non-genotoxic activation of p53 through p53 protein stabilization and transactivation of p53 target genes. Nutlin3a is the forerunner of a class of cancer therapeutics that have reached clinical trials. Using transgenic and gene-targeted mouse models lacking the critical p53 target genes, p21, Puma, and Noxa, we found that only loss of PUMA conferred profound protection against Nutlin3a-induced killing in both non-transformed lymphoid cells and Eμ-Myc lymphomas in vitro and in vivo. CRISPR/Cas9-mediated targeting of the PUMA gene rendered human hematopoietic cancer cell lines markedly resistant to Nutlin3a-induced cell death. These results demonstrate that PUMA-mediated apoptosis, but not p21-mediated cell-cycle arrest or senescence, is a critical determinant of the therapeutic response to non-genotoxic p53 activation by Nutlin3a. Importantly, in human cancer, PUMA expression may predict patient responses to treatment with MDM2 antagonists.

  6. Ibrutinib interferes with the cell-mediated anti-tumor activities of therapeutic CD20 antibodies: implications for combination therapy

    DEFF Research Database (Denmark)

    Da Roit, F.; Engelberts, P. J.; Taylor, R. P.;

    2015-01-01

    the possible positive or negative impact of these drugs on all known mechanisms of action of both type I and type II anti-CD20 antibodies. Pretreatment with ibrutinib for 1 hour did not increase direct cell death of cell lines or chronic lymphocytic leukemia samples mediated by anti-CD20 antibodies. Pre......-treatment with ibrutinib did not inhibit complement activation or complement-mediated lysis. In contrast, ibrutinib strongly inhibited all cell-mediated mechanisms induced by anti-CD20 antibodies rituximab, ofatumumab or obinutuzumab, either in purified systems or whole blood assays. Activation of natural killer cells...

  7. Angiogenesis in patients with psoriasis and psoriatic arthritis: cell-mediated and humoral mechanisms, its role in pathogenesis, and searching for promising therapeutic targets

    Directory of Open Access Journals (Sweden)

    T.V. Korotaeva

    2014-01-01

    Full Text Available Modern concepts of the role of angiogenesis in pathogenesis of psoriasis and psoriatic arthritis (PsA are analyzed. The features of cell-mediated and humoral immune responses resulting in proliferation of synovial membrane and vessel overgrowth in patients with this pathology are discussed. A number of angiogenesis mediators, pro-angiogenic cytokines, growth factors, matrix metalloproteinases, etc. are shown to be involved in progression of neovascularization. The role of tumor necrosis factor α as a key therapeutic target for treatment of psoriasis and PsA is emphasized. Drugs inhibiting some stages of angiogenesis, which are either used in clinical practice or are being developed, are discussed. 

  8. Revealing the Beauty behind the Sleeping Beauty Problem

    OpenAIRE

    Mariolis, Ioannis

    2014-01-01

    A large number of essays address the Sleeping Beauty problem, which undermines the validity of Bayesian inference and Bas Van Fraassen's 'Reflection Principle'. In this study a straightforward analysis of the problem based on probability theory is presented. The key difference from previous works is that apart from the random experiment imposed by the problem's description, a different one is also considered, in order to negate the confusion on the involved conditional probabilities. The resu...

  9. Mate choice decisions: the role of facial beauty.

    Science.gov (United States)

    Johnston, Victor S

    2006-01-01

    For most people, facial beauty appears to play a prominent role in choosing a mate. Evidence from research on facial attractiveness indicates that physical beauty is a sexually selected trait mediated, in part, by pubertal facial hormone markers that signal important biological information about the displayer. Such signals would be ineffective if they did not elicit appropriate cognitive and/or emotional responses in members of the opposite sex. In this article, I argue that the effectiveness of these hormonal displays varies with perceivers' brains, which have been organized by the degree of steroid hormone exposure in the uterus, and activated by varying levels of circulating steroids following puberty. I further propose that the methodology used for examining mate choice decisions has general applicability for determining how cognitive and emotional evaluations enter into decision processes.

  10. Ultrasound and Microbubble Mediated Doxil Delivery in a Murine Breast Cancer Model: Therapeutic Efficacy Dependence on Tumor Growth Rate

    NARCIS (Netherlands)

    Seip, R.; Leyvi, E.; Raju, B.I.; Shi, W.T.; Bohmer, M.R.; Chlon, C.H.T.; Sio, C.F.; Reibling, K.; Swanson, T.

    2011-01-01

    Background, Motivation and Objective: Localized drug delivery couldimprove the therapeutic efficacy for treatment of pathological lesions and reduce toxic exposure to healthy organs and tissues. The objective is to develop image-guided, ultrasound-activated tumor chemotherapy with intravenously admi

  11. What is the beauty standard?

    Institute of Scientific and Technical Information of China (English)

    谢华山

    2005-01-01

    最近,你校学生会组织学生开展了一场讨论,主题是:What is the beauty standard?假若你是学生会主席,请根据下表学生讨论的结果写份总结材料并谈谈对以上观点的看法。

  12. Facial beauty and fractal geometry

    OpenAIRE

    Schmidhuber, Juergen

    1998-01-01

    What is it that makes a face beautiful? Average faces obtained by photographic (Galton 1878) or digital (Langlois & Roggman 1990) blending are judged attractive but not optimally attractive (Alley & Cunningham 1991) --- digital exaggerations of deviations from average face blends can lead to higher attractiveness ratings (Perrett, May, & Yoshikawa 1994). My novel approach to face design does not involve blending at all. Instead, the image of a female face with high ratings is composed from a ...

  13. Therapeutic polypeptides based on HBV core 18-27 epitope can induce CD8+ CTL-mediated cytotoxicity in HLA-A2+ human PBMCs

    Institute of Scientific and Technical Information of China (English)

    Tong-Dong Shi; Yu-Zhang Wu; Zheng-Cai Jia; Li-Yun Zou; Wei Zhou

    2004-01-01

    AIM: To explore how to improve the immunogenicity of HBcAg CTL epitope based polypeptides and to trigger an HBV-specific HLA I-restricted CD8+ T cell response in vitro.METHODS: A new panel of mimetic therapeutic peptides based on the immunodominant B cell epitope of HBV PreS218-24 region, the CTL epitope of HBcAg18-27 and the universal T helper epitope of tetanus toxoid (TT) 830-843was designed using computerized molecular design method and synthesized by Merrifield's solid-phase peptide synthesis.Their immunological properties of stimulating activation and proliferation of lymphocytes, of inducing TH1 polarization,CD8+ T cell magnification and HBV-specific CD8+ CTL mediated cytotoxicity were investigatedin vitro using HLAA2+ human peripheral blood mononuclear cells (PBMCs) from healthy donors and chronic hepatitis B patients.RESULTS: Results demonstrated that the therapeutic polypeptides based on immunodominant HBcAg18-27 CTL,PreS2 B- and universal TH epitopes could stimulate the activation and proliferation of lymphocytes, induce specifically and effectively CD8+ T cell expansion and vigorous HBVspecific CTL-mediated cytotoxicity in human PBMCs.CONCLUSION: It indicated that the introduction of immunodominant T helper plus B-epitopes with short and flexible linkers could dramatically improve the immunogenicity of short CTL epitopes in vitro.

  14. Performing Beauty in Participatory Art and Culture

    DEFF Research Database (Denmark)

    Heinrich, Falk

    This book investigates the notion of beauty in participatory art, an interdisciplinary form that necessitates the audience’s agential participation and that is often seen in interactive art and technology-driven media installations. After considering established theories of beauty, for example......, Plato, Alison, Hume, Kant, Gadamer and Santayana through to McMahon and Sartwell, Heinrich argues that the experience of beauty in participatory art demands a revised notion of beauty; a conception that accounts for the performative and ludic turn within various art forms and which is, in a broader...... sense, a notion of beauty suited to a participatory and technology-saturated culture. Through case studies of participatory art, he provides an art-theoretical approach to the concept of performative beauty; an approach that is then applied to the wider context of media and design artefacts....

  15. Neutrophil-Mediated Delivery of Therapeutic Nanoparticles across Blood Vessel Barrier for Treatment of Inflammation and Infection.

    Science.gov (United States)

    Chu, Dafeng; Gao, Jin; Wang, Zhenjia

    2015-12-22

    Endothelial cells form a monolayer in lumen of blood vessels presenting a great barrier for delivery of therapeutic nanoparticles (NPs) into extravascular tissues where most diseases occur, such as inflammation disorders and infection. Here, we report a strategy for delivering therapeutic NPs across this blood vessel barrier by nanoparticle in situ hitchhiking activated neutrophils. Using intravital microscopy of TNF-α-induced inflammation of mouse cremaster venules and a mouse model of acute lung inflammation, we demonstrated that intravenously (iv) infused NPs made from denatured bovine serum albumin (BSA) were specifically internalized by activated neutrophils, and subsequently, the neutrophils containing NPs migrated across blood vessels into inflammatory tissues. When neutrophils were depleted using anti-Gr-1 in a mouse, the transport of albumin NPs across blood vessel walls was robustly abolished. Furthermore, it was found that albumin nanoparticle internalization did not affect neutrophil mobility and functions. Administration of drug-loaded albumin NPs markedly mitigated the lung inflammation induced by LPS (lipopolysaccharide) or infection by Pseudomonas aeruginosa. These results demonstrate the use of an albumin nanoparticle platform for in situ targeting of activated neutrophils for delivery of therapeutics across the blood vessel barriers into diseased sites. This study demonstrates our ability to hijack neutrophils to deliver nanoparticles to targeted diseased sites.

  16. Combined 2-deoxy glucose and metformin improves therapeutic efficacy of sodium-iodide symporter-mediated targeted radioiodine therapy in breast cancer cells.

    Science.gov (United States)

    Chatterjee, Sushmita; Thaker, Nirmal; De, Abhijit

    2015-01-01

    Radiosensitization using either metformin or 2-deoxy-d-glucose (2-DG) in various cancer cells has been reported. The present study reveals novel information on combining these drugs to enhance radiosensitization effect in breast cancer (BC) cells. Responses to low-dose Cobalt60 radiation, as well as a newly emerged radioiodine therapy target for BC, that is, sodium-iodide symporter (NIS or SLC5A5) protein, are tested. As therapeutic potential of NIS in BC is often limited due to low uptake and fast efflux rate of iodine, the scope of these two radiosensitizers to further improve NIS-mediated (131)I therapeutic efficacy is explored. Two BC cell lines, MCF-7, and MDA MB231 are tested to optimize minimal drug doses required for radiosensitization. A combination of 2 mM metformin and 20 mM 2-DG with 2 grey (Gy) Cobalt60 radiation shows significant radiosensitization effect (P=0.0002). In cells treated with the combination therapy, increased γH2A.X foci formation was noted. Further, MCF-7 BC cells overexpressing NIS (MCF-7 NIS) was established, and using the optimized drug concentrations, significant radiosensitization (P=0.0019) by 50 μ Ci (131)I usage was found to be the case as well. Apoptosis data corroborates with the result of clonogenic assay showing significant increase in apoptotic population upon dual drug-mediated radiosensitization. In case of metformin treatment, lowered adenosine triphosphate (ATP) content of the cell has been observed. The encouraging radiosensitization effect observed using combined 2-DG and metformin may aid in reducing Cobalt60 radiation exposure or for targeted radioiodine therapy in BC cells with NIS expression. This study indicates high potential of this drug combination in sensitizing BC cells for NIS-mediated-targeted radioiodine therapy, which otherwise may have lacked efficacy. PMID:26355636

  17. Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity.

    Science.gov (United States)

    Izzo, Nicholas J; Xu, Jinbin; Zeng, Chenbo; Kirk, Molly J; Mozzoni, Kelsie; Silky, Colleen; Rehak, Courtney; Yurko, Raymond; Look, Gary; Rishton, Gilbert; Safferstein, Hank; Cruchaga, Carlos; Goate, Alison; Cahill, Michael A; Arancio, Ottavio; Mach, Robert H; Craven, Rolf; Head, Elizabeth; LeVine, Harry; Spires-Jones, Tara L; Catalano, Susan M

    2014-01-01

    Amyloid beta (Abeta) 1-42 oligomers accumulate in brains of patients with Mild Cognitive Impairment (MCI) and disrupt synaptic plasticity processes that underlie memory formation. Synaptic binding of Abeta oligomers to several putative receptor proteins is reported to inhibit long-term potentiation, affect membrane trafficking and induce reversible spine loss in neurons, leading to impaired cognitive performance and ultimately to anterograde amnesia in the early stages of Alzheimer's disease (AD). We have identified a receptor not previously associated with AD that mediates the binding of Abeta oligomers to neurons, and describe novel therapeutic antagonists of this receptor capable of blocking Abeta toxic effects on synapses in vitro and cognitive deficits in vivo. Knockdown of sigma-2/PGRMC1 (progesterone receptor membrane component 1) protein expression in vitro using siRNA results in a highly correlated reduction in binding of exogenous Abeta oligomers to neurons of more than 90%. Expression of sigma-2/PGRMC1 is upregulated in vitro by treatment with Abeta oligomers, and is dysregulated in Alzheimer's disease patients' brain compared to age-matched, normal individuals. Specific, high affinity small molecule receptor antagonists and antibodies raised against specific regions on this receptor can displace synthetic Abeta oligomer binding to synaptic puncta in vitro and displace endogenous human AD patient oligomers from brain tissue sections in a dose-dependent manner. These receptor antagonists prevent and reverse the effects of Abeta oligomers on membrane trafficking and synapse loss in vitro and cognitive deficits in AD mouse models. These findings suggest sigma-2/PGRMC1 receptors mediate saturable oligomer binding to synaptic puncta on neurons and that brain penetrant, small molecules can displace endogenous and synthetic oligomers and improve cognitive deficits in AD models. We propose that sigma-2/PGRMC1 is a key mediator of the pathological effects of

  18. Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity.

    Directory of Open Access Journals (Sweden)

    Nicholas J Izzo

    Full Text Available Amyloid beta (Abeta 1-42 oligomers accumulate in brains of patients with Mild Cognitive Impairment (MCI and disrupt synaptic plasticity processes that underlie memory formation. Synaptic binding of Abeta oligomers to several putative receptor proteins is reported to inhibit long-term potentiation, affect membrane trafficking and induce reversible spine loss in neurons, leading to impaired cognitive performance and ultimately to anterograde amnesia in the early stages of Alzheimer's disease (AD. We have identified a receptor not previously associated with AD that mediates the binding of Abeta oligomers to neurons, and describe novel therapeutic antagonists of this receptor capable of blocking Abeta toxic effects on synapses in vitro and cognitive deficits in vivo. Knockdown of sigma-2/PGRMC1 (progesterone receptor membrane component 1 protein expression in vitro using siRNA results in a highly correlated reduction in binding of exogenous Abeta oligomers to neurons of more than 90%. Expression of sigma-2/PGRMC1 is upregulated in vitro by treatment with Abeta oligomers, and is dysregulated in Alzheimer's disease patients' brain compared to age-matched, normal individuals. Specific, high affinity small molecule receptor antagonists and antibodies raised against specific regions on this receptor can displace synthetic Abeta oligomer binding to synaptic puncta in vitro and displace endogenous human AD patient oligomers from brain tissue sections in a dose-dependent manner. These receptor antagonists prevent and reverse the effects of Abeta oligomers on membrane trafficking and synapse loss in vitro and cognitive deficits in AD mouse models. These findings suggest sigma-2/PGRMC1 receptors mediate saturable oligomer binding to synaptic puncta on neurons and that brain penetrant, small molecules can displace endogenous and synthetic oligomers and improve cognitive deficits in AD models. We propose that sigma-2/PGRMC1 is a key mediator of the pathological

  19. The realization of absolute beauty: an interpretation of the fairytale Snow White.

    Science.gov (United States)

    Takenaka, Nanae

    2016-09-01

    This paper interprets the fairytale Snow White (Bruder Grimm 1857) in terms of the realization of absolute beauty. Jung's understanding that 'in myths and fairytales, as in dreams, the soul speaks about itself' (Jung 1945, para. 400), underpins such an approach. From this perspective a fantasy image is not about us, not about our unconsciousness, but is essentially about itself. The idea of absolute beauty first arises in the Queen's mind as a wish. Despite the Queen's strong desire to be named as the most beautiful person in the world, her mirror reflects that it is actually her daughter Snow White who is the fairest. Snow White might be regarded in the language of Giegerich as her internal other. Effectively they are separated into the Real that conceives the idea of absolute beauty and the Ideal that embodies it. The exchange that takes place between the two - mediated by mirror and window - generates the corpse of surpassing beauty that never decays but lies inaccessible behind the glass coffin. However the loving and penetrating gaze of the Prince, representing masculinity, succeeds in reanimating Snow White. Thus the Prince as the Other that is completely external and unknown to both the Queen and Snow White, specifically to their femininity, facilitates the realization of absolute beauty as the Ideal in the Real.

  20. The realization of absolute beauty: an interpretation of the fairytale Snow White.

    Science.gov (United States)

    Takenaka, Nanae

    2016-09-01

    This paper interprets the fairytale Snow White (Bruder Grimm 1857) in terms of the realization of absolute beauty. Jung's understanding that 'in myths and fairytales, as in dreams, the soul speaks about itself' (Jung 1945, para. 400), underpins such an approach. From this perspective a fantasy image is not about us, not about our unconsciousness, but is essentially about itself. The idea of absolute beauty first arises in the Queen's mind as a wish. Despite the Queen's strong desire to be named as the most beautiful person in the world, her mirror reflects that it is actually her daughter Snow White who is the fairest. Snow White might be regarded in the language of Giegerich as her internal other. Effectively they are separated into the Real that conceives the idea of absolute beauty and the Ideal that embodies it. The exchange that takes place between the two - mediated by mirror and window - generates the corpse of surpassing beauty that never decays but lies inaccessible behind the glass coffin. However the loving and penetrating gaze of the Prince, representing masculinity, succeeds in reanimating Snow White. Thus the Prince as the Other that is completely external and unknown to both the Queen and Snow White, specifically to their femininity, facilitates the realization of absolute beauty as the Ideal in the Real. PMID:27530170

  1. Pluronic® L64-mediated stable HIF-1α expression in muscle for therapeutic angiogenesis in mouse hindlimb ischemia

    Science.gov (United States)

    Song, Hongmei; Liu, Sijia; Li, Caixia; Geng, Yanyan; Wang, Gang; Gu, Zhongwei

    2014-01-01

    Intramuscular injection of plasmid DNA (pDNA) to express a therapeutic protein is a promising method for the treatment of many diseases. However, the therapeutic applications are usually hindered by gene delivery efficiency and expression level. In this study, critical factors in a pDNA-based gene therapy system, such as gene delivery materials, a therapeutic gene, and its regulatory elements, were optimized to establish an integrated system for the treatment of mouse hindlimb ischemia. The results showed that Pluronic® L64 (L64) was an efficient and safe material for gene delivery into mouse skeletal muscle. It also showed intrinsic ability to promote in vivo angiogenesis in a concentration-dependent manner, which might be through the activation of nuclear factor kappa-light-chain-enhancer of activated B cell (NF-κB)-regulated angiogenic factors. The combination of 0.1% L64 with a hybrid gene promoter (pSC) increased the gene expression level, elongated the gene expression duration, and enhanced the number of transfected muscle fibers. In mice ischemic limbs, a gene medicine (pSC-HIF1αtri/L64) composed of L64 and pSC-based expression plasmid encoding hypoxia-inducible factor 1-alpha triple mutant (HIF-1αtri), improved the expression of stable HIF-1α, and in turn, the expression of multiple angiogenic factors. As a result, the ischemic limbs showed accelerated function recovery, reduced foot necrosis, faster blood reperfusion, and higher capillary density. These results indicated that the pSC-HIF1αtri/L64 combination presented a potential and convenient venue for the treatment of peripheral vascular diseases, especially critical limb ischemia. PMID:25092975

  2. Beauty and critical art: is beauty at odds with critical–political engagement?

    Directory of Open Access Journals (Sweden)

    Maria-Alina Asavei

    2015-06-01

    Full Text Available Traditionally, beauty is understood as an ability of some objects (artworks included to occasion in viewers a distinctive type of unmediated/pure pleasure—aesthetic pleasure. According to this common understanding of beauty, political–critical art does not seem to raise in viewers the feeling of aesthetic pleasure. Many contemporary critical artists and politically engaged artists deliberately produce an art as unappealing to the senses as possible (their attitude could be called, following Arthur Danto, kalliphobia—“beauty phobia”. Critical art is a type of art which usually does not strike us with beauty at first sight because this “political art” usually deals with issues of social injustice and political struggles, rendering contemplation and aesthetic pure pleasure unachievable. Yet, even if beauty, in critical art's case, seems to be a difficult, demanding, and not an immediately recognisable one (mostly because of its unappealing, unsettling look, this does not mean that it lacks or is at odds with critical engagement (as some critical artists and theorists have argued. The argument of this paper is that not every beautiful thing looks good at first sight. By the same token, not everything that looks beautiful is in fact beautiful. Drawing on Immanuel Kant's neglected pulchritude adhaerens (dependent beauty, I argue that political–critical art is characterised by a dependent type of beauty (beauty a thing has as a thing of a certain kind and with a certain function as opposed to free beauty (as something we like it freely on its own account, independent of what it is and what it does. Political–critical art can claim a dependent beauty (an impure, “difficult” and not straightforward pleasurable type of beauty without being compelled to submit itself, at the same time, to the free beauty.

  3. Pluronic® L64-mediated stable HIF-1α expression in muscle for therapeutic angiogenesis in mouse hindlimb ischemia

    OpenAIRE

    Wang, Gang

    2014-01-01

    Hongmei Song,1 Sijia Liu,1 Caixia Li,1,2 Yanyan Geng,1,3 Gang Wang,1 Zhongwei Gu1 1National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, People’s Republic of China; 2Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, People’s Republic of China; 3Hebei University of Engineering, Handan, Hebei, People’s Republic of China Abstract: Intramuscular injection of plasmid DNA (pDNA) to express a therapeutic protein is a pro...

  4. Pluronic® L64-mediated stable HIF-1α expression in muscle for therapeutic angiogenesis in mouse hindlimb ischemia

    OpenAIRE

    Song H; Liu S; Li C.; Geng Y; Wang G; Gu Z

    2014-01-01

    Hongmei Song,1 Sijia Liu,1 Caixia Li,1,2 Yanyan Geng,1,3 Gang Wang,1 Zhongwei Gu1 1National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, People’s Republic of China; 2Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, People’s Republic of China; 3Hebei University of Engineering, Handan, Hebei, People’s Republic of China Abstract: Intramuscular injection of plasmid DNA (pDNA) to express a therapeutic protein is a promising metho...

  5. Antimicrobial peptides: mediators of innate immunity as templates for the development of novel anti-infective and immune therapeutics.

    Science.gov (United States)

    Hiemstra, P S; Fernie-King, B A; McMichael, J; Lachmann, P J; Sallenave, J-M

    2004-01-01

    Antimicrobial molecules are ancient and essential small cationic molecules of the host defence system which are found in a wide variety of species. They display antimicrobial activity against a wide range of bacteria, fungi and viruses, an activity that has been mostly attributed to the disruption of microbial membranes. In this article, we will review the "classical" functions of 3 classes of antimicrobial molecules, namely defensins, cathelicidins, and the four-disulfide core proteins secretory leukocyte proteinase inhibitor (SLPI) and elafin. In addition to the study of their expression in a variety of cell types and the regulation of their production, we will also describe novel properties of these molecules that have been highlighted by recent studies. These include their ability to chemoattract a variety of inflammatory, immune and other cell types (neutrophils, macrophages, monocytes, lymphocytes, mast cells, epithelial cells) in vitro and in vivo. In addition, we will discuss the potential use of these newly discovered properties for therapeutic or vaccination purposes, using protein- or gene-transfer based methodologies. Finally, we will examine in an extensive fashion the strategies used by microorganisms to circumvent and subvert host defence mechanisms, such as the modifications of cell membranes and walls, the secretion of inactivating proteins and proteases and the down-regulation of expression of antimicrobial molecules. Increased understanding of the mechanisms used by both the host and the microbes to 'win the battle' may ultimately lead to new therapeutic strategies aimed to treat infectious diseases. PMID:15379675

  6. Antimicrobial peptides: mediators of innate immunity as templates for the development of novel anti-infective and immune therapeutics.

    Science.gov (United States)

    Hiemstra, P S; Fernie-King, B A; McMichael, J; Lachmann, P J; Sallenave, J-M

    2004-01-01

    Antimicrobial molecules are ancient and essential small cationic molecules of the host defence system which are found in a wide variety of species. They display antimicrobial activity against a wide range of bacteria, fungi and viruses, an activity that has been mostly attributed to the disruption of microbial membranes. In this article, we will review the "classical" functions of 3 classes of antimicrobial molecules, namely defensins, cathelicidins, and the four-disulfide core proteins secretory leukocyte proteinase inhibitor (SLPI) and elafin. In addition to the study of their expression in a variety of cell types and the regulation of their production, we will also describe novel properties of these molecules that have been highlighted by recent studies. These include their ability to chemoattract a variety of inflammatory, immune and other cell types (neutrophils, macrophages, monocytes, lymphocytes, mast cells, epithelial cells) in vitro and in vivo. In addition, we will discuss the potential use of these newly discovered properties for therapeutic or vaccination purposes, using protein- or gene-transfer based methodologies. Finally, we will examine in an extensive fashion the strategies used by microorganisms to circumvent and subvert host defence mechanisms, such as the modifications of cell membranes and walls, the secretion of inactivating proteins and proteases and the down-regulation of expression of antimicrobial molecules. Increased understanding of the mechanisms used by both the host and the microbes to 'win the battle' may ultimately lead to new therapeutic strategies aimed to treat infectious diseases.

  7. My Beautiful Relationship with China

    Institute of Scientific and Technical Information of China (English)

    Gian; Franco; Terenzi

    2014-01-01

    <正>The beautiful story of friendship began in 1987 when I served as Captain Regent(Head of State)of San Marino.Back then,I had some knowledge of China and decided to realize my dream of paying an offi cial visit there during my tenure.It was my first trip,so I did not know what was awaiting me.However,I was sure it would be something positive.At the head of a delegation,I arrived in China in February 1988.The reception was meticulous and incom-

  8. Markkinointisuunnitelma RVB Beauty Clinic Kotka

    OpenAIRE

    Piipponen, Tiia

    2012-01-01

    Työn tarkoituksena oli tehdä markkinointisuunnitelma RVB Beauty Clinic Kotkalle. Tavoitteena oli selvittää yrityksen nykytilanne käytössä olevien tietolähteiden avulla ja luoda näiden perusteella selkeitä linjauksia yrityksen markkinointiin. Markkinointisuunnitelmaa lähdin luomaan asiakassuhdemarkkinoinnin näkökulmasta, koska kyseessä on yritys, jossa työskentelee vain yksi henkilö. Lähtötilanteen selvityksessä käytin yrittäjän ja maahantuojan haastatteluja, kilpailijoiden kotisivuja ja e...

  9. Beautiful Mirrors at the LHC

    OpenAIRE

    Kumar, Kunal; Shepherd, William; Tait, Tim M. P.; Vega-Morales, Roberto(Laboratoire de Physique Théorique, CNRS-UMR 8627, Université Paris-Sud 11, F-91405, Orsay Cedex, France)

    2010-01-01

    We explore the "Beautiful Mirrors" model, which aims to explain the measured value of $A^b_{FB}$, discrepant at the $2.9\\sigma$ level. This scenario introduces vector-like quarks which mix with the bottom, subtly affecting its coupling to the $Z$. The spectrum of the new particles consists of two bottom-like quarks and a charge -4/3 quark, all of which have electroweak interactions with the third generation. We explore the phenomenology and discovery reach for these new particles at the LHC, ...

  10. A Beautiful Proof by Induction

    OpenAIRE

    Öhman, Lars-Daniel

    2016-01-01

    The purpose of this note is to present an example of a proof by induction that in the opinion of the present author has great aesthetic value. The proof in question is Thomassen’s proof that planar graphs are 5-choosable. I give a self-contained presentation of this result and its proof, and a personal account of why I think this proof is beautiful. A secondary purpose is to more widely publicize this gem, and hopefully make it part of a standard set of examples for examining characteristics ...

  11. Perceiving beauty in all women: Psychometric evaluation of the Broad Conceptualization of Beauty Scale.

    Science.gov (United States)

    Tylka, Tracy L; Iannantuono, Amy C

    2016-06-01

    Women's ability to broadly conceptualize beauty (i.e., perceive many looks, appearances, body sizes/shapes, and inner characteristics as beautiful) has been identified as a facet of positive body image in qualitative research. A scale is needed to be able to assess this construct within quantitative research. Therefore, we developed the Broad Conceptualization of Beauty Scale (BCBS), which measures the extent women define female beauty widely within external and internal characteristics, and examined its psychometric properties among four community samples totaling 1086 women. Exploratory and confirmatory factor analyses revealed a unidimensional structure with nine items. The internal consistency, test-retest reliability, and construct (convergent, discriminant, and incremental) validity of its scores were upheld. Researchers and clinicians can use the BCBS alone to assess women's perceptions of female beauty, or they can use the BCBS alongside women's perceptions of self-beauty to more comprehensively explore women's ability to broadly conceptualize beauty for others and themselves.

  12. Perceiving beauty in all women: Psychometric evaluation of the Broad Conceptualization of Beauty Scale.

    Science.gov (United States)

    Tylka, Tracy L; Iannantuono, Amy C

    2016-06-01

    Women's ability to broadly conceptualize beauty (i.e., perceive many looks, appearances, body sizes/shapes, and inner characteristics as beautiful) has been identified as a facet of positive body image in qualitative research. A scale is needed to be able to assess this construct within quantitative research. Therefore, we developed the Broad Conceptualization of Beauty Scale (BCBS), which measures the extent women define female beauty widely within external and internal characteristics, and examined its psychometric properties among four community samples totaling 1086 women. Exploratory and confirmatory factor analyses revealed a unidimensional structure with nine items. The internal consistency, test-retest reliability, and construct (convergent, discriminant, and incremental) validity of its scores were upheld. Researchers and clinicians can use the BCBS alone to assess women's perceptions of female beauty, or they can use the BCBS alongside women's perceptions of self-beauty to more comprehensively explore women's ability to broadly conceptualize beauty for others and themselves. PMID:26971117

  13. Pluronic® L64-mediated stable HIF-1α expression in muscle for therapeutic angiogenesis in mouse hindlimb ischemia

    Directory of Open Access Journals (Sweden)

    Song H

    2014-07-01

    Full Text Available Hongmei Song,1 Sijia Liu,1 Caixia Li,1,2 Yanyan Geng,1,3 Gang Wang,1 Zhongwei Gu1 1National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, People’s Republic of China; 2Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, People’s Republic of China; 3Hebei University of Engineering, Handan, Hebei, People’s Republic of China Abstract: Intramuscular injection of plasmid DNA (pDNA to express a therapeutic protein is a promising method for the treatment of many diseases. However, the therapeutic applications are usually hindered by gene delivery efficiency and expression level. In this study, critical factors in a pDNA-based gene therapy system, such as gene delivery materials, a therapeutic gene, and its regulatory elements, were optimized to establish an integrated system for the treatment of mouse hindlimb ischemia. The results showed that Pluronic® L64 (L64 was an efficient and safe material for gene delivery into mouse skeletal muscle. It also showed intrinsic ability to promote in vivo angiogenesis in a concentration-dependent manner, which might be through the activation of nuclear factor kappa-light-chain-enhancer of activated B cell (NF-κB-regulated angiogenic factors. The combination of 0.1% L64 with a hybrid gene promoter (pSC increased the gene expression level, elongated the gene expression duration, and enhanced the number of transfected muscle fibers. In mice ischemic limbs, a gene medicine (pSC-HIF1αtri/L64 composed of L64 and pSC-based expression plasmid encoding hypoxia-inducible factor 1-alpha triple mutant (HIF-1αtri, improved the expression of stable HIF-1α, and in turn, the expression of multiple angiogenic factors. As a result, the ischemic limbs showed accelerated function recovery, reduced foot necrosis, faster blood reperfusion, and higher capillary density. These results indicated that the pSC-HIF1αtri/L64 combination presented a potential and convenient venue for

  14. Free Harmonious Beauty of Greek Sculpture

    Institute of Scientific and Technical Information of China (English)

    郑晓杨

    2015-01-01

    Greek art in the content and form of the art of the beautiful, harmonious effect fully expresses the interpretation of the height of the spirit of freedom, and the Greek sculpture is a powerful representative of Greek art. In this paper, from a few large sculpture art to savor the Greek sculpture artistic freedom and harmonious beauty.

  15. Is Beauty an Archaic Spirit in Education?

    Science.gov (United States)

    Cannatella, Howard

    2006-01-01

    This article discusses the unfashionable and taboo idea that beauty matters. The author's supposition is that beauty as a poetic force should be regarded as one of the defining characteristics central to pedagogic practice. In making this claim he draws upon a few of Charles Dickens' and William Wordsworth's ideas in support of the importance of…

  16. ATTRACTION OF STUDENTS TOWARDS BEAUTY PRODUCTS

    Directory of Open Access Journals (Sweden)

    Fouzia Ali

    2011-07-01

    Full Text Available The purpose of this study was to measure the correlation and impact of deceptive beauty advertising (Ads with and on the buying behavior of the university students toward beauty products. Developed instrument contained nineteen questions. Five point Likert scale was used and the response rate was 94.667%. Two variables were computed; buying behavior of university students towards beauty products was dependent variable; and deceptive beauty ads were independent variable. Descriptive statistics, correlation and liner regression techniques were used with the help of SPSS 16. Positive and significant correlation and impact was found with and on the buying behavior of university students toward beauty products which means that the use of beauty products increases with the increase in deception in beauty products ads. The data were collected from university students and non-serious attitude of students were the limitations of this study. In this study, the main focus was on the buying behavior of students and beauty products ads, and it will serve as a benchmark for prospective researchers for future study.

  17. Beautiful Exit: Break Up With A Smile

    OpenAIRE

    Alajoutsijärvi, K; MÖller, K.; Tähtinen, J. (Jaana)

    1999-01-01

    This paper constructs a framework describing communication strategies available in dissolving interorganisational buyer-seller relationships. In particular, we bring in a quality aspect, as we are looking for strategies that could be labelled "beautiful exits". A beautiful exit is achieved by using a communication strategy that minimises damages occurring to the disengager, the other party and the connected network.

  18. Charm and beauty physics at Fermilab

    International Nuclear Information System (INIS)

    The status of charm and beauty physics studies at Fermilab is reviewed. Data from fixed target experiments on charm production, semi-leptonic decay, and Cabibbo suppressed decays as well as charmonium studies in antiproton annihilation are described. In addition beauty results from CDF and E653 are reviewed and prospects for studies of B physics at collider detectors are discussed

  19. Antitumor activity and prolonged survival by carbon-nanotube-mediated therapeutic siRNA silencing in a human lung xenograft model.

    Science.gov (United States)

    Podesta, Jennifer E; Al-Jamal, Khuloud T; Herrero, M Antonia; Tian, Bowen; Ali-Boucetta, Hanene; Hegde, Vikas; Bianco, Alberto; Prato, Maurizio; Kostarelos, Kostas

    2009-05-01

    Carbon nanotubes are novel nanomaterials that are thought to offer potential benefits to a variety of biomedical and clinical applications. In this study, the treatment of a human lung carcinoma model in vivo using siRNA sequences leading to cytotoxicity and cell death is carried out using either cationic liposomes (DOTAP:cholesterol) or amino-functionalized multi-walled carbon nanotubes (MWNT - NH(+)(3)). Validation for the most cytotoxic siRNA sequence using a panel of human carcinoma and murine cells reveals that the proprietary siTOX sequence is human specific and can lead to significant cytotoxic activities delivered both by liposome or MWNT - NH(+)(3) in vitro. A comparative study using both types of vector indicates that only MWNT - NH(+)(3):siRNA complexes administered intratumorally can elicit delayed tumor growth and increased survival of xenograft-bearing animals. siTOX delivery via the cationic MWNT - NH(+)(3) is biologically active in vivo by triggering an apoptotic cascade, leading to extensive necrosis of the human tumor mass. This suggests that carbon-nanotube-mediated delivery of siRNA by intratumoral administration leads to successful and statistically significant suppression of tumor volume, followed by a concomitant prolongation of survival of human lung tumor-bearing animals. The direct comparison between carbon nanotubes and liposomes demonstrates the potential advantages offered by carbon nanotubes for the intracellular delivery of therapeutic agents in vivo. The present work may act as the impetus for further studies to explore the therapeutic capacity of chemically functionalized carbon nanotubes to deliver siRNA directly into the cytoplasm of target cells and achieve effective therapeutic silencing in various disease indications where local delivery is feasible or desirable.

  20. Transcriptionally regulated and nontoxic delivery of the hyperactive Sleeping Beauty Transposase.

    Science.gov (United States)

    Cocchiarella, Fabienne; Latella, Maria Carmela; Basile, Valentina; Miselli, Francesca; Galla, Melanie; Imbriano, Carol; Recchia, Alessandra

    2016-01-01

    The Sleeping Beauty (SB) transposase and, in particular, its hyperactive variant SB100X raises increasing interest for gene therapy application, including genome modification and, more recently, induced pluripotent stem cells (iPS) reprogramming. The documented cytotoxicity of the transposase, when constitutively expressed by an integrating retroviral vector (iRV), has been circumvented by the transient delivery of SB100X using retroviral mRNA transfer. In this study, we developed an alternative, safe, and efficient transposase delivery system based on a tetracycline-ON regulated expression cassette and the rtTA2(S)-M2 transactivator gene transiently delivered by integration-defective lentiviral vectors (IDLVs). Compared with iRV-mediated delivery, expression of tetracycline-induced SB100X delivered by an IDLV results in more efficient integration of a GFP transposon and reduced toxicity. Tightly regulated expression and reactivation of the transposase was achieved in HeLa cells as wells as in human primary keratinocytes. Based on these properties, the regulated transposase-IDLV vectors may represent a valuable tool for genetic engineering and therapeutic gene transfer. PMID:27574698

  1. Transcriptionally regulated and nontoxic delivery of the hyperactive Sleeping Beauty Transposase.

    Science.gov (United States)

    Cocchiarella, Fabienne; Latella, Maria Carmela; Basile, Valentina; Miselli, Francesca; Galla, Melanie; Imbriano, Carol; Recchia, Alessandra

    2016-01-01

    The Sleeping Beauty (SB) transposase and, in particular, its hyperactive variant SB100X raises increasing interest for gene therapy application, including genome modification and, more recently, induced pluripotent stem cells (iPS) reprogramming. The documented cytotoxicity of the transposase, when constitutively expressed by an integrating retroviral vector (iRV), has been circumvented by the transient delivery of SB100X using retroviral mRNA transfer. In this study, we developed an alternative, safe, and efficient transposase delivery system based on a tetracycline-ON regulated expression cassette and the rtTA2(S)-M2 transactivator gene transiently delivered by integration-defective lentiviral vectors (IDLVs). Compared with iRV-mediated delivery, expression of tetracycline-induced SB100X delivered by an IDLV results in more efficient integration of a GFP transposon and reduced toxicity. Tightly regulated expression and reactivation of the transposase was achieved in HeLa cells as wells as in human primary keratinocytes. Based on these properties, the regulated transposase-IDLV vectors may represent a valuable tool for genetic engineering and therapeutic gene transfer.

  2. The DREAM complex mediates GIST cell quiescence and is a novel therapeutic target to enhance imatinib-induced apoptosis.

    Science.gov (United States)

    Boichuk, Sergei; Parry, Joshua A; Makielski, Kathleen R; Litovchick, Larisa; Baron, Julianne L; Zewe, James P; Wozniak, Agnieszka; Mehalek, Keith R; Korzeniewski, Nina; Seneviratne, Danushka S; Schöffski, Patrick; Debiec-Rychter, Maria; DeCaprio, James A; Duensing, Anette

    2013-08-15

    Gastrointestinal stromal tumors (GIST) can be successfully treated with imatinib mesylate (Gleevec); however, complete remissions are rare and patients frequently achieve disease stabilization in the presence of residual tumor masses. The clinical observation that discontinuation of treatment can lead to tumor progression suggests that residual tumor cells are, in fact, quiescent and, therefore, able to re-enter the cell-division cycle. In line with this notion, we have previously shown that imatinib induces GIST cell quiescence in vitro through the APC(CDH1)-SKP2-p27(Kip1) signaling axis. Here, we provide evidence that imatinib induces GIST cell quiescence in vivo and that this process also involves the DREAM complex, a multisubunit complex that has recently been identified as an additional key regulator of quiescence. Importantly, inhibition of DREAM complex formation by depletion of the DREAM regulatory kinase DYRK1A or its target LIN52 was found to enhance imatinib-induced cell death. Our results show that imatinib induces apoptosis in a fraction of GIST cells while, at the same time, a subset of cells undergoes quiescence involving the DREAM complex. Inhibition of this process enhances imatinib-induced apoptosis, which opens the opportunity for future therapeutic interventions to target the DREAM complex for more efficient imatinib responses. PMID:23786773

  3. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie; Kwok

    2011-01-01

    <正>01抗敏医美学>据说橄榄树非常长寿,可以健康地存活1000年,所以科学家相信橄榄树含有保持青春的成分,知名的皮肤科医生及抗衰老专家Nicholas Perricone博士研发的Perricone MD护肤品牌,就是以橄榄叶及其果实的天然分子橄榄多酚为敏感肌肤带来有效护理的抗衰老系列。

  4. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Chris

    2010-01-01

    <正>01Christian Dior贵族淑女踏春归来随着马蹄声的配乐响起,Christian Dior宣布贵族淑女的时代回归。绣花、珍珠、花朵这些春意盎然的细节都运用到了薄纱以及各种轻盈的材质上。马鞭与马靴还有骑马的高帽搭配着长裙,优雅帅气的骑士装扮瞬间抓住了在场女士们的心。在妆容上,化妆师

  5. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie; Kwok

    2011-01-01

    <正>01闪耀细胞思维论〉Cle de Peau Beaute认为每一个皮肤细胞,犹如脑细胞一样,能够自我思考。它们均具有处理各种情报的能力,只要有效管理细胞使之接收更多正面讯息,阻截负面情报,提升肌肤本身的机制优化细胞机能,便能诱导更多正面讯息能量的吸收,从而改善皮肤质量。而全新Basic Care系列,便是因应闪耀细胞管理而研发。

  6. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Jasmine; Chris

    2010-01-01

    <正>022010 Chanel春夏高级成衣发布会后台彩妆探秘在这场仿佛是法国皇后Marie Antoinette在凡尔赛宫的小农庄重现的时装秀上,除了精致奢华的新款时装令人眼前一亮之外,彩妆创意总监Peter Phillips在妆容上也为我们带来了新一年的流行趋势,那就是以高雅别致的米色调为主,打造令人耳目一新、清新富有朝气的妆容。这种邻家女孩味十足的妆容效果,基本适合所有的女性,所有的场合。如果你嫌妆容过于"平淡",那

  7. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie Kwok

    2012-01-01

    <正>01皇室御用彩妆盒〉Cle de peau Beaute邀得皇室御用珠宝设计师Shaun Leane,为春夏特别推出的Luminizing Face Enhancer设计一个闪烁夺目的盒子。Shaun Leane曾任皇室御用珠宝师及Alexander McQueen的首席珠宝设计师。他是英国FlPG获奖者,该奖项专门表扬技术超凡的珠宝匠师。精美闪烁的宝石切割面粉盒,一丝不苟的设计,令彩妆盒精致如珠宝盒一样,带有高贵优雅气派。Shaun Leane指出:"最初构思包装设计时,第一个念头是塑造既富触感又美观的盒子。在美感方面,我们希望设计宛如一件多琢面的

  8. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Kidd Ji

    2010-01-01

    <正>01Rene Gruau与美妆传承法国画家Rene Gruau的重要,不仅来自他独特的虚实结合水彩风格,将东西方绘画艺术相结合,令20世纪中期的人们耳目一新。他与Dior品牌合作,让插画与Dior在50年代推出的"New Look"风格紧密结合,流畅大气的线条勾勒出明显的女性曲线,修身、高雅、大气,这些插画与人们脑中的Dior服饰产生了不可分割的联系。2010年11月10日至2011年1月9日,名为"Dior插画展:Rene Gruau与美妆传承"的展览将于伦敦萨默塞特宫隆重举行。这场展览将向公众展现里程碑式的艺术珍品,荟集了经严格甄选的Dior高级定制礼服,以及Gruau特别为Dior香水化妆品品牌、古董香水瓶、时装手绘稿和杂志精心绘就的原创插画。六位英国出生的插画家亦将应邀在此次展览中展示画作,Gruau与Dior迪奥品牌的无间合作正是他们的灵感源泉。

  9. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Paris; Sun

    2011-01-01

    <正>01美妆拜占庭拜占庭艺术(Byzantine art)指东罗马帝国的艺术。大体来说,所有拜占庭的艺术都充满了精神的象征主义。重视心象,不容有写实主义的存在。为配合Chanel巴黎一拜占庭高级手工坊系列成衣发布,Chanel全球彩妆创意总监彼德·菲利浦斯以世界知名的狄奥多拉女皇Theodora的马赛克肖像图为灵感创作了一组妆容,而肖像图中女皇眉峰部分所描绘的红色眼影线条,被他用作了这次妆

  10. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Kidd Ji

    2010-01-01

    <正>01Chanel 2010 Couture Makeup在高级订制服的秀场上,时装及配饰不但影响着未来一至两季的服装潮流,模特的妆容作为整个系列的点睛之笔,也对妆容的流行指明方向。由Chanel全球彩妆创意总监Peter Philips为秋冬高级订制系列创作的红色概念妆容就是其中一个例子。Peter Philips表示,他的设计概念来自Karl Lagerfeld向他展示的设计草图:"我发现他在所有的模特嘴上都加上了一抹红色。而他展示给我看的第一件外套也是红色

  11. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie Kwok

    2012-01-01

    <正>01救生员认可的有机防晒美国生态环境研究专家Chris Birchby的家人,不幸患上黑色素瘤,令他明白防晒的重要,同时作为生态环境研究专家,他亦希望护肤品不会加重地球的负担,所以研发出防晒品牌COOLA,以有机天然成分为主,同时以物理性及化学性的防晒配方,推出高效的防晒产品,除了获得各个有机认证外,亦获得美国救生员协会的认可。

  12. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Kidd Ji

    2010-01-01

    <正>01悦木之源"眼咖啡">一直以为,累了、困了只要一杯咖啡就能提神解乏。却没想到,咖啡的活力还能喂进眼睛里,仿佛永远没有睡醒的倦怠双眼,在遇见悦木之源人参活力焕亮眼霜之后便能苏醒。这款在业界素有"精神眼霜"、"眼咖啡"、"加班眼霜"等众多俏皮昵称的Origins GinzingTM人参活力焕亮眼霜优选两款醒神植物能量——"百草之王"人参与"醒神之王"咖啡,同时融汇了冬虫夏草、木兰花、锦紫苏、橙皮苷、黄芩、绿茶等多种活力秘方,能够有效针对改善黑眼圈、眼部浮肿和眼疲劳等眼部问题,仿佛给倦眼来一杯Espresso。

  13. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie Kwok

    2012-01-01

    <正>01蜗牛美容秘辛〉早于1980年,智利皮肤科医生Mr.Fernando Bascunan就已发现蜗牛分泌物具有非凡的护肤功效。当时他的家族以养殖蜗牛为生,并出口至欧洲各国成为美食。多年来在处理蜗牛的过程中,Fernando Bascunan意外地发现,工人被工具刮伤的患处不但没有发炎伤口愈合会更快,也不会留下疤痕。自此以后,他就开始对蜗牛进行研究,发现蜗牛黏液可在人类皮肤上产生嫩肤、再生及修复的神奇功效。近年来不少美容品牌都开始投放资源,研发蜗牛黏液护肤品,其中来自韩国的MISSHA,以韩国锦

  14. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie Kwok

    2012-01-01

    <正>01意大利大家闺秀>Valentino除了经典的火红女郎形象外,近年时装秀的蕾丝都充分表现出品牌对女性妩媚的诠释。而今次Valentino的首支吞氛更是为其女性时装及生活方式所启发。为了这支香氛像是一束综合了多种鲜花精炼而成的香味,选用的材料都极度女性化,充分代表了Valentino女性的独特气质,因此便以Valentina命名。品牌邀两位杰出的调香师:Oliver Cresp

  15. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie; Kwok

    2011-01-01

    <正>01从不泛黄的照片谈美白>现在什么都谈数码化,数码相机的科技水平也越来越高,但是十分值得纪念的相片,还是会有冲印出来的冲动。富士牌的相机胶卷你一定听过用过吧,用它冲印出来的相片,不论经过多少年,相片上的颜色不只没有泛黄,更没有褪色。原来,照相的相机胶卷是用骨胶原制成的。相同道理,如果富士能将相机胶卷用的骨胶原保持最佳状态,它们亦会知道怎样保护我们皮肤的骨胶原。所以当富士推出Fijifilm beauty系列,对女士们来说,可谓福音!

  16. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie Kwok

    2012-01-01

    <正>01摩诃之美>摩诃本为梵文,在佛教中有超越有情与无情,在无边无际、有形与无形之间显得圆通神妙用的意思。正如Cle de PeauBeaute秋冬妆容系列,以光亮色彩从黑暗中反映出来,以阴影映衬着明亮的双眸,以光泽衬托出不一样的色彩。品牌的彩妆美容形象师Lucia Pieroni说:"色彩在黑暗中绽亮生辉,令眼影细滑如丝。炯炯有神的明眸,在色彩与质感交织下美丽迷人,映照神秘的黑夜。"而系列最新三款让人惊艳的眼影色调,以散发不同光芒的珠光组合塑造聚光焦点,色彩中若隐若现的光泽,在瞳孔中映照出神秘光芒,演绎高贵优雅的魅力。色调可随意混配,

  17. Beauty

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

    <正>眉:自然生态眉首先要扭转精致、服帖、细长才是完美眉形的观念。选择比发色淡一度的眉粉自下眉头处1cm处为起点,向眉峰轻扫,进而顺延至眉尾,别忘记用余粉将眉毛边缘处做好过渡。最后用眉形修饰膏以先顺再逆的方向梳理眉毛,缔造根根分明的印象。眼:亚洲人的内陷式双眼皮,令彩色眼线往往不足以提升眼晴的精气神。双色眼线以深色在靠近内眼睑的位置铺底,此处精细和轻巧的眼尾上挑是关键,然后用明媚的彩色眼线以略宽出1~2cm的方式勾勒,霎时拥有明眸点睛的魅惑力。

  18. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie; Kwok

    2011-01-01

    <正>01有机"炼金术">古时人们相信可以从金属中提炼长生不老的丹药,虽然现代科学已证实炼金术不能提炼所谓"仙丹",但却令人类对物质和化学有了进一步的认识和了解。因为这些知识,让我们可以从自然环境中萃取各种天然成分,合成及研发成各种不只对皮肤或身体有益的产品,更有效地减少了浪费和不必要的消耗。

  19. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Chris

    2010-01-01

    <正>01DNA科技注入睫毛膏>在护肤品中添加生物基因技术,已不再是什么大新闻。但你听说过,在睫毛膏里也加入这一科技吗?7月即将问市的Lancome全新梦魅臻采睫毛膏,就以兰蔻高科技研究成果为基础,加入了独一无二的基因配比技术,用以启动睫毛干细胞的活性,促进干细胞新生,仿佛为睫毛注入第二次生命般,让睫毛变长变密。同时,特别研制的刷头,可以更好的让膏体和睫毛接触,达到更完美的浓睫艳眸效果。www.lancome.com

  20. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Kidd; Ji; Paris; Sun

    2011-01-01

    <正>01纸艺幻发纸艺能成为备受关注的艺术形态,是因为纸本身拥有轻盈及可塑性强的特质,再配合极富想象力的创作,即能呈现出千变万化的视觉形象,承载无限艺术价值。沙宣认为头发与纸艺的创作概念如出一辙,今年冬季亦从纸艺中汲取灵感,设计出了轻盈、可塑的概念发型。以"逆重幻觉"为名的发型特辑借用纸艺"挣脱重力的束缚仿佛能够对抗万有引力的存在"这一概念,丰盈的发型在充满空气感的同时,造型上也十分具有纸张所带来的结构感。当被问及如何打造这样的发型时,其创意总监回答:"关键在于拥有轻盈可塑的健康秀发。"道理虽不难,达到却不易。

  1. Beauty

    Institute of Scientific and Technical Information of China (English)

    James; Stephen; Behrens; 王海强

    2006-01-01

    古往今来,人们一直通过语言、艺术或思考来探究人生的真谛。有人以追求人生的真理为乐,甚至是舍生取义;也有人在追求真理的过程中不断完善自己的生命。本文以朴实的文笔娓娓述说了一个令人深思而嗟叹的故事。故事女主人公相貌丑陋,但却以她独特的灵气、细腻的美感、动人的话语征服了人心。她对待人生的态度和生活的勇气,无疑会令所有的身体健康者汗颜!

  2. Beauty

    Institute of Scientific and Technical Information of China (English)

    Katie Kwok

    2012-01-01

    <正>01澳大利亚有机美发>澳大利亚天然资源丰富,所以不少美容品牌都从当地的有机农庄获取原材料,主要因为有机草本成分内含的维他命、矿物质等营养成分比非有机草本植物高,同时有助减少吸收不必要的抗生素、农药等化学成分,令消费者更安心使用。澳洲进口品牌australian organics,在澳洲拥有十五年历史,产品包括面部护理、沐浴及身体护理以及头发护理系列。其有机成分获澳洲国家可持续农业协会机构(NASAA)认可,并属澳洲低碳产品商认可成员,全部产品均于澳洲制造,绝对不含石化成分、人造香料、色素及任何基因改造和动物测试,成分温和,容易吸收,特别适合亚洲人肌肤。品牌根据不同发质及肌肤需要,以天然草本成分调配不同配方外,亦以舒缓、减压、安抚情绪、助眠等有机香熏精华调配而成,让秀发及头部皮肤获得细致呵护之余,于感官上也同时得到洗涤,令日常护理程序变得更轻松。

  3. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    <正> 今年起,说到最有效的抗氧化成分,你脑中该留下一个新名词"IDEBENONE 艾地苯"。这种由 ELIZABETH ARDEN 携手 BOTOX 肉毒杆菌素的创造者——ALLERGAN 联手推出的新成分已被运用在"PREVAGE 逆时橘灿精纯凝露"中,掀起了全球医学美容热潮。被称为"抗氧化超人"的它在18岁后即可每天使用,对抗光老化及预防皱纹。

  4. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Chris

    2010-01-01

    <正>01帝王之水典藏版华丽开售>现在你不必亲身飞到巴黎或香港等地,Guerlain巴黎之家专属限量香氛上海梅龙镇伊势丹精品专柜店将在7月隆重揭幕。作为国内唯一一家精品店,也是香榭丽舍大道68号LaMaison Guerlain娇兰之家的华丽缩影,在此你可以独家购买到帝王之水金箔蜂姿琉金典藏版等多款限量版香水。帝王之水乃品牌创始人Pierre Francois Pascal为法国Eugenie皇后特别制作的新婚礼物,清新、芬芳而怡神的它,是橙花、香橼、柠檬、

  5. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Kidd; Ji; Paris; Sun

    2011-01-01

    <正>01一片蓝心向北非Giorgio Armani用一种颜色完成了2011春夏女装秀,撒哈拉沙漠中部游牧民族图阿雷格人的文化就是其女装的灵感来源。而品牌彩妆的特质在于其质感和色彩都基于时装的灵感、布料的材质之上。2011年春夏妆容,其灵感同样延续来自图阿雷格人面纱的颜色——靛蓝。设计师Giorgio Armani认为:"蓝与黑的搭配会让经典的黑色更有生命力。"通过对蓝色和黑色搭配的重新诠释,赋予了品牌招牌式优雅更富故事性与情境感的篇章。

  6. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Chris

    2010-01-01

    <正>01至真"纸"美>美国时装真人秀节目《Project Runway》在最近的一期节目里,请参赛者们用牛皮纸来代替寻常的布料,做出属于自己的牛皮纸时装,结果平时表现平平的参赛者都发挥得不错。原因何在?牛皮纸那朴实无华,却坚韧有型的特色赋予了"材料"更多的可塑性,同时也呼应了当下全球大热的

  7. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    2014-01-01

    <正>眼部的流线美学2014秋冬的T台妆容,醒目又流畅的眼妆深入人心,能够一根根修饰睫毛的睫毛刷,触感光滑柔软的丝绒效果眼影,勾勒夸张猫眼效果的厚泽眼线,所有的产品都重在打造自然流畅中可扩大眼形的清秀眼妆。01细致巧妙地提亮肌肤疲惫黯淡区域圣罗兰明彩笔1#2.5ml/RMB36002柔滑质感与千变万化的妆效圣罗兰臻彩四色眼影5#5g/RMB56003惊艳系列,打造含情脉脉的眼神迪奥单色眼影3g/RMB31004打造诱惑双眸的波普粉色迪奥魅惑睫毛膏9ml/RMB36005精致珍珠母贝令双眸晶莹闪亮希恩黎植物炫彩眼影06极其柔软,幼滑的眼线笔希思黎植物丝缎眼线笔

  8. Beauty

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    一年之中,可以好好重整肌肤状况的有两个时段,分别是3,4月和10,11月,这两个时节,肌肤刚从剧烈的换季变化中回复平稳,最适合趁机除去累积的废物,并补充肌肤所需的营养,就像大病之后需要恢复元气一样。

  9. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie; Kwok

    2011-01-01

    <正>01植村秀东京眼妆美学〉植村秀这彩妆品牌相信是不少潮流达人的心头好,不只因为其一流品质,更因为品牌从来以"不停构思改进与发掘"为哲学,不断推陈出新。今季炎夏,配合自由配搭彩妆盒,及全新系列眼影色系,品牌打造个人独特的彩妆盒。彩妆盒由日本著名建筑师干久美子设计,简洁优雅之余,亦令彩妆盒不需使用任何黏贴工具,亦能轻松替换眼影及胭脂组合。

  10. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie Kwok

    2012-01-01

    <正>01好莱坞巨星的活肤秘诀>由匈牙利皮肤科医生Dr.Laszlo创办的纽约品牌Emo Laszlo,一直深受皇室名人及好莱坞巨星的喜爱,今年是Emo Laszlo创立八十五周年,特别以五位家喻户晓的好莱坞女星为灵感,推出八十五周年限量版好莱坞尊贵系列。五款尊贵系列的原装产品分别为珍珠亮采唤肤啫喱、魅惑水润修护眼霜、Refresh尊贵宝石再生补湿霜、搪瓷肌抗氧化修护霜及丝滑

  11. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Kidd Ji

    2010-01-01

    <正>01逆转光老化>光老化是目前被认为肌肤衰老的最大元凶。有害的紫外线深入肌肤深处,直接伤害细胞DNA,破坏肌肤自我更新过程,同时引发自由基,对肌肤造成进一步的间接伤害。在美国,激光被运用在光老化引起的皱纹、松弛的肌肤治疗上,因为术后红肿的反应并不多,所以很多人都能接受。但你需要为之付出疼痛感和一到两万元的高额费用。随着美容产品技术的提高与开发,基于医学美容的CLINIQUE

  12. Beauty

    Institute of Scientific and Technical Information of China (English)

    Jasmine; Chris

    2010-01-01

    <正>03Jean Paul Gaultier 2010春夏高级订制:梦游"奇幻乐园"〉老顽童Jean Paul Gaultier这次给彩妆大师Tom Pecheux出了一个趣味横生的妆容课题—fantasy land。于是Tom Pecheux把墨西哥人、外星人、甚至是热映的电影《Avatar》都搬上了T台。模特们的妆容被大自然的缤纷色彩所填满,限部以天空蓝、植物绿、夕阳橙和大地黄为

  13. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Paris; Sun

    2011-01-01

    <正>01Aesop来自澳洲的"伊索寓言">"伊索寓言"在巴黎上演,Aesop巴黎店最新橱窗展,伊索灵魂漫游于方寸橱窗间。成立于1987年的澳洲品牌伊索(Aesop),在纯天然植物护肤的基础上率先推行有机理念,并结合内外调理的"理智"生活哲学。出身于拥有最多濒临绝种的奇花异草、珍禽怪兽的澳大利亚净土,品牌从研发、测试到

  14. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie; Kwok

    2011-01-01

    <正>01台湾有机>说起护肤品的出产地,瑞士美国等欧美传统美容王国当然占市场大部分位置,但有时候因气候水土不同,在美国用起来一流的产品,来到亚洲可能就要大打折扣。近年除了韩国,台湾出产的美容护肤产品亦大受欢迎,除了一流的质量外,价位亦十分相宜。以统欣生物科技公司旗下品牌之一Deary媞尔妮为例,在身体及脸部保养品领域开发专研,以有机草本原料,配合独特研发技术,其面膜销售更是台湾连锁便利店排行第一。统欣生物科技公司,除了研发有效的护肤品之余,亦对护

  15. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Jasmine; Chris

    2009-01-01

    <正>01寻找秋冬发型灵感>Aveda刚发表了新一季发型及发色潮流造型照,品牌的环球创作总监Antoinette Beenders介绍这系列灵感启发自80年代的歌德式华丽,他说:"今季的造型设计大量运用了复古味极浓的经典剪裁和发色。"一如以往,Aveda的造型设计无论是发型及发色都相当实用,参考价值甚高,想改变造型又没有头绪的话,可到品牌的网址找找合心意的发色与发型,更有来自世界各地的造型师所提供的理发建议。除此之外,可留意这辑造型照的另一个特别之处:模特儿所穿的礼服,全采用可循环再用的物料制造,如旧报纸、旧牛仔布料及风衣等,重新解构再造,非常合乎Aveda的环保原则。

  16. Beauty

    Institute of Scientific and Technical Information of China (English)

    Jasmine; Chris

    2010-01-01

    <正>01沪上定制妆容〉香奈儿巴黎——上海高级手工坊将时尚大帝Karl Lagerfeld和彩妆大师Peter Philips都带来了上海,除了为上海度身定做的华服之外,那颇有东方韵味的妆容也令人印象深刻。Peter在采访中透露这次妆面的灵感来自Karl给他看的一部电影——《花样年华》。模特们的妆容需要看上去既要有像张曼玉穿旗袍时的优雅,又能表现出如未来女战士般的魄力。正如服装秀一开场,模特们所穿着服装的灵

  17. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie Kwok

    2012-01-01

    <正>01世界海洋大同>La Mer的世界海洋日活动,不仅要提升大家对海洋美态和修复力量的关注,更要呼吁人们对它脆弱的生态多加爱惜。La Mer相信海洋植物如太平洋海藻,其惊人力量尚未被完全发掘及理解,所以我们应全力支持生态保育,为下一代守护并保存这大自然的瑰宝。今年的世界海洋日活动鼓励大众探索、发掘和欣赏海洋宝库。La Mer特别设计了一百毫升的世界海洋日Creme de la Mer限量版面霜,瓶身设计的灵感亦撷取

  18. BEAUTY

    Institute of Scientific and Technical Information of China (English)

    Katie; Kwok

    2011-01-01

    <正>01Burberry Body全新香氛>Burberry Body找来英国女演员兼模特儿Rosie Huntington-Whiteley,让她成为品牌的第一位代言人,从她身上完美地体现出感性、自信和谦逊的平衡。全新香氛使用的成分亦不简单,除了以天然玫瑰精油和香草为基调外,前调的苦艾酒曾一度是欧洲禁酒,也是梵高每次画画必喝的最爱。品牌还在香水瓶上花了不少心思,品牌刨作总监Christopher Bailey表示:"我常将

  19. The monoclonal antibody Zt/f2 targeting RON receptor tyrosine kinase as potential therapeutics against tumor growth-mediated by colon cancer cells

    Directory of Open Access Journals (Sweden)

    Zhang Rui-Wen

    2011-07-01

    Full Text Available Abstract Background Overexpression of the RON receptor tyrosine kinase contributes to epithelial cell transformation, malignant progression, and acquired drug resistance. RON also has been considered as a potential target for therapeutic intervention. This study determines biochemical features and inhibitory activity of a mouse monoclonal antibody (mAb Zt/f2 in experimental cancer therapy. Results Zt/f2 is a mouse IgG2a mAb that is highly specific and sensitive to human RON and its oncogenic variants such as RON160 (ED50 = 2.3 nmol/L. Receptor binding studies revealed that Zt/f2 interacts with an epitope(s located in a 49 amino acid sequence coded by exon 11 in the RON β-chain extracellular sequences. This sequence is critical in regulating RON maturation and phosphorylation. Zt/f2 did not compete with ligand macrophage-stimulating protein for binding to RON; however, its engagement effectively induced RON internalization, which diminishes RON expression and impairs downstream signaling activation. These biochemical features provide the cellular basis for the use of Zt/f2 to inhibit tumor growth in animal model. Repeated administration of Zt/f2 as a single agent into Balb/c mice results in partial inhibition of tumor growth caused by transformed NIH-3T3 cells expressing oncogenic RON160. Colon cancer HT-29 cell-mediated tumor growth in athymic nude mice also was attenuated following Zt/f2 treatment. In both cases, ~50% inhibition of tumor growth as measured by tumor volume was achieved. Moreover, Zt/f2 in combination with 5-fluorouracil showed an enhanced inhibition effect of ~80% on HT-29 cell-mediated tumor growth in vivo. Conclusions Zt/f2 is a potential therapeutic mAb capable of inhibiting RON-mediated oncogenesis by colon cancer cells in animal models. The inhibitory effect of Zt/f2 in vivo in combination with chemoagent 5-fluorouracil could represent a novel strategy for future colon cancer therapy.

  20. Combined 2-deoxy glucose and metformin improves therapeutic efficacy of sodium-iodide symporter-mediated targeted radioiodine therapy in breast cancer cells

    Directory of Open Access Journals (Sweden)

    Chatterjee S

    2015-08-01

    Full Text Available Sushmita Chatterjee, Nirmal Thaker, Abhijit DeMolecular Functional Imaging Laboratory, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai, IndiaAbstract: Radiosensitization using either metformin or 2-deoxy-d-glucose (2-DG in various cancer cells has been reported. The present study reveals novel information on combining these drugs to enhance radiosensitization effect in breast cancer (BC cells. Responses to low-dose Cobalt60 radiation, as well as a newly emerged radioiodine therapy target for BC, that is, sodium-iodide symporter (NIS or SLC5A5 protein, are tested. As therapeutic potential of NIS in BC is often limited due to low uptake and fast efflux rate of iodine, the scope of these two radiosensitizers to further improve NIS-mediated 131I therapeutic efficacy is explored. Two BC cell lines, MCF-7, and MDA MB231 are tested to optimize minimal drug doses required for radiosensitization. A combination of 2 mM metformin and 20 mM 2-DG with 2 grey (Gy Cobalt60 radiation shows significant radiosensitization effect (P=0.0002. In cells treated with the combination therapy, increased γH2A.X foci formation was noted. Further, MCF-7 BC cells overexpressing NIS (MCF-7 NIS was established, and using the optimized drug concentrations, significant radiosensitization (P=0.0019 by 50 µ Ci 131I usage was found to be the case as well. Apoptosis data corroborates with the result of clonogenic assay showing significant increase in apoptotic population upon dual drug-mediated radiosensitization. In case of metformin treatment, lowered adenosine triphosphate (ATP content of the cell has been observed. The encouraging radiosensitization effect observed using combined 2-DG and metformin may aid in reducing Cobalt60 radiation exposure or for targeted radioiodine therapy in BC cells with NIS expression. This study indicates high potential of this drug combination in sensitizing BC cells for NIS-mediated

  1. Therapeutic rAAVrh10 Mediated SOD1 Silencing in Adult SOD1(G93A) Mice and Nonhuman Primates.

    Science.gov (United States)

    Borel, Florie; Gernoux, Gwladys; Cardozo, Brynn; Metterville, Jake P; Toro Cabreja, Gabriela C; Song, Lina; Su, Qin; Gao, Guang Ping; Elmallah, Mai K; Brown, Robert H; Mueller, Christian

    2016-01-01

    Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease; survival in ALS is typically 3-5 years. No treatment extends patient survival by more than three months. Approximately 20% of familial ALS and 1-3% of sporadic ALS patients carry a mutation in the gene encoding superoxide dismutase 1 (SOD1). In a transgenic ALS mouse model expressing the mutant SOD1(G93A) protein, silencing the SOD1 gene prolongs survival. One study reports a therapeutic effect of silencing the SOD1 gene in systemically treated adult ALS mice; this was achieved with a short hairpin RNA, a silencing molecule that has raised multiple safety concerns, and recombinant adeno-associated virus (rAAV) 9. We report here a silencing method based on an artificial microRNA termed miR-SOD1 systemically delivered using adeno-associated virus rAAVrh10, a serotype with a demonstrated safety profile in CNS clinical trials. Silencing of SOD1 in adult SOD1(G93A) transgenic mice with this construct profoundly delayed both disease onset and death in the SOD1(G93A) mice, and significantly preserved muscle strength and motor and respiratory functions. We also document that intrathecal delivery of the same rAAVrh10-miR-SOD1 in nonhuman primates significantly and safely silences SOD1 in lower motor neurons. This study supports the view that rAAVrh10-miR-SOD1 merits further development for the treatment of SOD1-linked ALS in humans. PMID:26710998

  2. Bathing in Reeking Wounds: The Liberal Arts, Beauty, and War

    Science.gov (United States)

    Stimpson, Catharine R.

    2014-01-01

    A historic dialectic exists between the beautiful and the bestial. The bestial destroys the beautiful, but in a bloody miracle, the beautiful emerges from the womb of the bestial, the "terrible beauty" of which the poet W. B. Yeats wrote. The liberal arts, so often thought to dwell in a remote ivory tower, embody this dialectic. Wars and…

  3. Beauty and Cuteness in Peripheral Vision

    Directory of Open Access Journals (Sweden)

    Kana eKuraguchi

    2015-05-01

    Full Text Available Guo, Liu, & Roebuck (2011 showed that attractiveness was detectable in peripheral vision. Since there are different types of attractiveness (Rhodes, 2006, we investigated how beauty and cuteness are detected in peripheral vision with a brief presentation. Participants (n = 45 observed two Japanese female faces for 100 ms, then were asked to respond which face was more beautiful (or cuter. The results indicated that both beauty and cuteness were detectable in peripheral vision, but not in the same manner. Discrimination rates for judging beauty were invariant in peripheral and central vision, while discrimination rates for judging cuteness declined in peripheral vision as compared with central vision. This was not explained by lower resolution in peripheral vision. In addition, for male participants, it was more difficult to judge cuteness than beauty in peripheral vision, thus suggesting that gender differences can have a certain effect when judging cuteness. Therefore, central vision might be suitable for judging cuteness while judging beauty might not be affected by either central or peripheral vision. This might be related with the functional difference between beauty and cuteness.

  4. Pig transgenesis by Sleeping Beauty DNA transposition

    DEFF Research Database (Denmark)

    Jakobsen, Jannik E.; Li, Juan; Kragh, Peter M.;

    2011-01-01

    disease models. In this report, we present transgenic pigs created by Sleeping Beauty DNA transposition in primary porcine fibroblasts in combination with somatic cell nuclear transfer by handmade cloning. Göttingen minipigs expressing green fluorescent protein are produced by transgenesis with DNA...... plasmid DNA. Our findings illustrate critical issues related to DNA transposon-directed transgenesis, including coincidental plasmid insertion and relatively low Sleeping Beauty transposition activity in porcine fibroblasts, but also provide a platform for future development of porcine disease models...... using the Sleeping Beauty gene insertion technology....

  5. Charm and Beauty in Photoproduction at HERA

    Science.gov (United States)

    Dobre, Monica

    2014-04-01

    The photoproduction of beauty and charm quarks at the ep collider HERA are presented. The b-quarks production was investigated in the bb → eeX' channel and the differential production cross section was measured as a function of the average transverse momentum of the beauty quarks down to the threshold. The cross section of D* meson decaying in the golden channel was determined both inclusively and in D*-tagged dijet events. Exploiting the characteristics of the heavy-flavoured hadron decays, beauty and charm quark cross sections were also measured in dijet events using secondary vertices or semi-muonic decays.

  6. Particle identification for beauty physics

    Energy Technology Data Exchange (ETDEWEB)

    Ludlam, T.

    1987-01-01

    We look briefly at the requirements for particle identification for possible beauty experiments at the Tevatron, both in the fixed target and the collider mode. Techniques presently in use in high energy physics experiments, and under development, should make sensitive experiments feasible. However, in all cases the present state of the art must be advanced to meet the necessary requirements for segmentation andor rate capability. The most fundamentally difficult challenges appear to be the efficient tagging of soft electrons (for the collider experiment) and the need to handle interaction rates up to /approximately/ 10/sub 9/ HZ in the fixed target mode. In both cases we can find ''in principle'' demonstrations that the requirements can be met. We have considered only the most basic prooperties of detectors, however, and the real answers will come from careful studies of details. 20 refs., 10 figs.

  7. Exhibition - Mathematics, A Beautiful Elsewhere

    CERN Multimedia

    2011-01-01

    From 21 October 2011 to 18 March 2012, the Fondation Cartier pour l’art contemporain will present the exhibition Mathematics: A Beautiful Elsewhere, an exhibition developed in association with the Institut des Hautes Études Scientifiques (IHÉS) and under the patronage of UNESCO. For this unprecedented event, the foundation invited mathematicians to work with artists with whom it has previously worked to create an exhibition that allows visitors to see, hear, do, interpret and think about mathematics. By bringing mathematics into its premises, the Fondation Cartier is itself undergoing the “sudden change of scenery” described by mathematician Alexandre Grothendieck. More information is available here. Fondation Cartier pour l’art contemporain 261, boulevard Raspail 75014 Paris http://fondation.cartier.com Private Visit For professors, researchers and all the staff of Mathematics departments...

  8. My beautiful hometown Gao Chun

    Institute of Scientific and Technical Information of China (English)

    王晟

    2010-01-01

    @@ In the southwestern part of Jiangsu Province,the southern suburbs of the ancient city of Nanjing,there is a magical and quaint land, distributing the heat,revealing fascinating charm like a brilliant pearl. It has natural ecology(自然生态),beautiful scenery and rich resources(富饶的资源)and has got the famous reputation of being a land of fish and rice(鱼米之乡 ).This is Gaochun, the Jiangnan Holy Land (江南胜地) called by the Qianlong emperor(乾隆皇帝)in Qing Dynasty and now it is one of the Top 100 Counties(百强县之一), Red Sun Corporation and Wu Jiazui Jinling First Richest Village belong to Gao Chun.

  9. Experimental situation of beauty oscillations

    International Nuclear Information System (INIS)

    The experimental situation of the evidences for beauty oscillations is reviewed. After a brief description of the formalism the results from the CERN proton-antiproton collider are described and compared with the results from electron-positron colliders. Whereas the experiments on the continuum measure a mixture of χs and χd the experiments on the Υ (4s) are only sensitive to χd. A forecast for 1992 is given and a method is described which allows to measure χs. A precision measurement of χs would allow to further constrain the CKM matrix and would eventually lead to a determination of the phase in the matrix

  10. Beautiful mirrors at the LHC.

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, K.; Shepherd, W.; Tait, T. M. P.; Vega-Morales, R.; High Energy Physics; Northwestern Univ; Univ. of California at Irvine

    2010-01-01

    We explore the 'Beautiful Mirrors' model, which aims to explain the measured value of A{sub FB}{sup b}, discrepant at the 2.9{sigma} level. This scenario introduces vector-like quarks which mix with the bottom, subtly affecting its coupling to the Z. The spectrum of the new particles consists of two bottom-like quarks and a charge -4/3 quark, all of which have electroweak interactions with the third generation. We explore the phenomenology and discovery reach for these new particles at the LHC, exploring single mirror quark production modes whose rates are proportional to the same mixing parameters which resolve the A{sub FB}{sup b} anomaly. We find that for mirror quark masses {approx}< 500 GeV, a 14 TeV LHC with 300 fb{sup -1} is required to reasonably establish the scenario and extract the relevant mixing parameters.

  11. Is beauty skin deep – an approach to a beautiful face

    Directory of Open Access Journals (Sweden)

    Neerja Puri

    2014-07-01

    Full Text Available Everyone dreams of a beautiful and flawless face but true beauty is God given gift. Plastic surgery and various filler techniques can just highlight certain features and are just the temporary procedures. Features that further enhance the attractiveness of a beautiful face are the hair, skin, and teeth. These areas are the easiest to routinely enhance. There are many methods of facial sculpting including botulinum toxin, fillers and various other invasive plastic surgery techniques.

  12. Is beauty skin deep – an approach to a beautiful face

    OpenAIRE

    Neerja Puri

    2014-01-01

    Everyone dreams of a beautiful and flawless face but true beauty is God given gift. Plastic surgery and various filler techniques can just highlight certain features and are just the temporary procedures. Features that further enhance the attractiveness of a beautiful face are the hair, skin, and teeth. These areas are the easiest to routinely enhance. There are many methods of facial sculpting including botulinum toxin, fillers and various other invasive plastic surgery techniques.

  13. Past and Future Perfect? Beauty, Affect and Hope

    OpenAIRE

    Coleman, Rebecca

    2010-01-01

    This article engages with and draws on what have been called two recent “turns” in feminist theory: to beauty and to affect. While much feminist research has concentrated on the beauty industry, where beauty is conceived as a series of economic, social and cultural practices, the authors suggest that beauty should also be understood as an embodied affective process. The authors’ focus is on understanding the conceptions of beauty that emerged in their own empirical work with white British gir...

  14. The Relation between the ideal of beauty and dependent beauty in Kant's philosophy

    Directory of Open Access Journals (Sweden)

    Javad Amin

    2015-10-01

    Full Text Available Kant organizes his analysis in terms of four moments of the judgment of taste, each of which is supposed to contribute something essential to the complete exposition of the beautiful in "Critique of Judgment". He, in the third moment, based on the key concept analysis of "purposiveness", reaches to the beauty definition "a purposiveness without a purpose" (subjective purposiveness. Below this moment, two concepts of "dependent beauty" and "the ideal of beauty" also arises that aesthetic judgment in both of them is based on an objective purposiveness and a concept indicating nature of the object and the perfection of the object that is considered as default for judgment. This default in dependent beauty is perfection of the object and in the ideal of beauty is a concept from the sum of the rational idea and the aesthetic normal idea, but this point of view is in contradiction with the principle of Kant's aesthetic, which judgment of the beautiful just relies on the subjective purposiveness. This article reviewing the concept of purposiveness and the type of subjective purposiveness in the ideal of beauty and dependent beauty, attempts to explain the aesthetic value of these concepts and their differences and similarities, and finally to determine the position of these two concepts in Kant's philosophy.

  15. Neuroaesthetics and the trouble with beauty.

    Science.gov (United States)

    Conway, Bevil R; Rehding, Alexander

    2013-01-01

    Neuroscience is increasingly being called upon to address issues within the humanities. We discuss challenges that arise, relating to art and beauty, and provide ideas for a way forward. PMID:23526878

  16. Neuroaesthetics and the trouble with beauty.

    Directory of Open Access Journals (Sweden)

    Bevil R Conway

    Full Text Available Neuroscience is increasingly being called upon to address issues within the humanities. We discuss challenges that arise, relating to art and beauty, and provide ideas for a way forward.

  17. Examination of nanoformulated crosslinked polymers complexed with copper/zinc superoxide dismutase as a therapeutic strategy for angiotensin II-mediated hypertension

    Science.gov (United States)

    Savalia, Krupa

    Excessive generation of superoxide (O2·-) has been extensively implicated as a signaling molecule in cardiovascular pathologies, including hypertension. As a major risk factor for myocardial infarction, stroke, and heart failure, the morbidity and mortality associated with hypertension is a worldwide epidemic. Although there are several standard therapies that effectively lower blood pressure, many hypertensive patients have uncontrolled blood pressure despite taking available medications. Thus, there is a necessity to develop new pharmacotherapies that target novel molecular effectors (e.g. O2·-) that have been implicated to be integral in the pathogenesis of hypertension. To overcome the failed therapeutic impact of currently available antioxidants in cardiovascular disease, we developed a nanomedicine-based delivery system for the O2 ·- scavenging enzyme, copper/zinc superoxide dismutase (CuZnSOD), in which CuZnSOD protein is electrostatically bound to poly-L-lysine (PLL 50)-polyethylene glycol (PEG) block co-polymer to form CuZnSOD nanozyme. Different formulations of CuZnSOD nanozyme are covalently stabilized by either reducible or non-reducible crosslinked bonds between the PLL50-PEG polymers. Herein, we tested the overall hypothesis that PLL50-PEG CuZnSOD nanozyme delivers active CuZnSOD protein to neurons and decreases blood pressure in a model of Angll-dependent hypertension. As determined by electron paramagnetic resonance (EPR) spectroscopy, nanozymes retain full SOD enzymatic activity. Furthermore, non-reducible crosslinked nanozyme delivers active CuZnSOD protein to central neurons in culture (CATH.a neurons) without inducing significant neuronal toxicity. In vivo studies conducted in Angll-mediated hypertensive adult male C57BL/6 mice demonstrate that the non-reducible crosslinked nanozyme significantly attenuates blood pressure when given directly into the brain and prevents the further increase in hypertension when intravenously (IV) administered

  18. Charm, beauty and top at HERA

    Science.gov (United States)

    Behnke, O.; Geiser, A.; Lisovyi, M.

    2015-09-01

    Results on open charm and beauty production and on the search for top production in high-energy electron-proton collisions at HERA are reviewed. This includes a discussion of relevant theoretical aspects, a summary of the available measurements and measurement techniques, and their impact on improved understanding of QCD and its parameters, such as parton density functions and charm- and beauty-quark masses. The impact of these results on measurements at the LHC and elsewhere is also addressed.

  19. Charm, Beauty and Top at HERA

    CERN Document Server

    Behnke, O; Lisovyi, M

    2015-01-01

    Results on open charm and beauty production and on the search for top production in high-energy electron-proton collisions at HERA are reviewed. This includes a discussion of relevant theoretical aspects, a summary of the available measurements and measurement techniques, and their impact on improved understanding of QCD and its parameters, such as parton density functions and charm- and beauty-quark masses. The impact of these results on measurements at the LHC and elsewhere is also addressed.

  20. Charm, Beauty and Top at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Behnke, O.; Geiser, A.; Lisovyi, M.

    2015-06-15

    Results on open charm and beauty production and on the search for top production in high-energy electron-proton collisions at HERA are reviewed. This includes a discussion of relevant theoretical aspects, a summary of the available measurements and measurement techniques, and their impact on improved understanding of QCD and its parameters, such as parton density functions and charm- and beauty-quark masses. The impact of these results on measurements at the LHC and elsewhere is also addressed.

  1. Hadronic couplings of open beauty states

    International Nuclear Information System (INIS)

    Strong interaction coupling parameters of particles with beauty quantum number are obtained using dispersion sum rules in various forms, e.g. current algebra sum rules, superconvergence sum rules and finite energy sum rules etc. These sum rules lead to a set of algebraic relations among masses and coupling constants. We compare the hadronic couplings of beautiful particles as obtained from various techniques and discuss their implications on the hadronic production of these states. (author)

  2. Lifetimes of charm and beauty hadrons

    International Nuclear Information System (INIS)

    Recent results on the lifetimes of charm and beauty hadrons at the LEP collider experiment and at the fixed target experiments E653 are reviewed and discussed. The world average of b lifetime is now =1.29±0.05 ps. The exclusive lifetime measurements for b+, b-, b0 are presented. The lifetime difference among the different species of charm and of beauty hadrons are discussed. (author) 25 refs., 13 figs., 12 tabs

  3. Beautiful mesons from QCD spectral sum rules

    Energy Technology Data Exchange (ETDEWEB)

    Narison, S. (OPM, Univ. Montpellier 2, 34 (France))

    1991-08-01

    We discuss the beautiful meson from the point of view of the QCD spectral sum rules (QSSR). The bottom quark mass and the mixed light quark-gluon condensates are determined quite accurately. The decay constant f{sub B} is estimated and we present some arguments supporting this result. The decay constants and the masses of the other members of the beautiful meson family are predicted. (orig.).

  4. On the Beautiful and the Ugly

    OpenAIRE

    Herman Parret

    2011-01-01

    Classical aesthetics sees the experience of the beautiful as an anthropological necessity. But, in fact, the beautiful is rather the central category designating classical art, and one can question the relevance of this category considering contemporary art. The reference term most frequently used for contemporary art is interesting: works of art solicit the interests of my faculties (the cognitive-intellectual, the pragmatic community-oriented moral, the affective aesthetic faculties). It is...

  5. Charm, Beauty and Top at HERA

    International Nuclear Information System (INIS)

    Results on open charm and beauty production and on the search for top production in high-energy electron-proton collisions at HERA are reviewed. This includes a discussion of relevant theoretical aspects, a summary of the available measurements and measurement techniques, and their impact on improved understanding of QCD and its parameters, such as parton density functions and charm- and beauty-quark masses. The impact of these results on measurements at the LHC and elsewhere is also addressed.

  6. Collapsin Response Mediator Protein-2 (CRMP2) is a Plausible Etiological Factor and Potential Therapeutic Target in Alzheimer's Disease: Comparison and Contrast with Microtubule-Associated Protein Tau.

    Science.gov (United States)

    Hensley, Kenneth; Kursula, Petri

    2016-04-15

    Alzheimer's disease (AD) has long been viewed as a pathology that must be caused either by aberrant amyloid-β protein precursor (AβPP) processing, dysfunctional tau protein processing, or a combination of these two factors. This is a reasonable assumption because amyloid-β peptide (Aβ) accumulation and tau hyperphosphorylation are the defining histological features in AD, and because AβPP and tau mutations can cause AD in humans or AD-like features in animal models. Nonetheless, other protein players are emerging that one can argue are significant etiological players in subsets of AD and potentially novel, druggable targets. In particular, the microtubule-associated protein CRMP2 (collapsin response mediator protein-2) bears striking analogies to tau and is similarly relevant to AD. Like tau, CRMP2 dynamically regulates microtubule stability; it is acted upon by the same kinases; collects similarly in neurofibrillary tangles (NFTs); and when sequestered in NFTs, complexes with critical synapse-stabilizing factors. Additionally, CRMP2 is becoming recognized as an important adaptor protein involved in vesicle trafficking, amyloidogenesis and autophagy, in ways that tau is not. This review systematically compares the biology of CRMP2 to that of tau in the context of AD and explores the hypothesis that CRMP2 is an etiologically significant protein in AD and participates in pathways that can be rationally engaged for therapeutic benefit.

  7. The therapeutic response of CDDO-Me in the esophageal squamous cell carcinoma (ESCC) cells is mediated by CaMKIIα.

    Science.gov (United States)

    Wang, Yan-Yang; Zhou, Shun; Zhao, Ren; Hai, Ping; Zhe, Hong

    2016-01-01

    CDDO-Me has exhibited a potent anticancer effect in human esophageal squamous cell carcinoma (ESCC) cells in our previous study, but the molecular interactome remains elusive. We applied the approach of stable-isotope labeling by amino acids in cell culture (SILAC) to assess the proteomic responses of CDDO-Me treatment in human ESCC Ec109 cells. The data were subsequently validated using Western blot assay. The results of our study revealed that CDDO-Me increased the expression level of 543 protein molecules, but decreased the expression level of 709 protein molecules in Ec109 cells. Among these modulated protein molecules, calcium/calmodulin-dependent protein kinase type II subunit α (CaMKIIα) was highly expressed in all tested ESCC cell lines, whereas its expression levels were substantially lower in normal control cell line. Its silencing by small interfering RNA inhibited CDDO-Me induced apoptosis and autophagy in ESCC cells. Collectively, these data demonstrate that the therapeutic response of CDDO-Me in the human ESCC cells is mediated by CaMKIIα.

  8. Materialised Ideals Sizes and Beauty

    Directory of Open Access Journals (Sweden)

    Kirsi Laitala

    2011-04-01

    Full Text Available Today’s clothing industry is based on a system where clothes are made in ready-to-wear sizes and meant to fit most people. Studies have pointed out that consumers are discontent with the use of these systems: size designations are not accurate enough to find clothing that fits, and different sizes are poorly available. This article discusses in depth who these consumers are, and which consumer groups are the most dissatisfied with today’s sizing systems. Results are based on a web survey where 2834 Nordic consumers responded, complemented with eight in-depth interviews, market analysis on clothing sizes and in-store trouser size measurements. Results indicate that higher shares of the consumers who have a body out of touch with the existing beauty ideals express discontentment with the sizing systems and the poor selection available. In particular, large women, very large men, and thin, short men are those who experience less priority in clothing stores and have more difficulties in finding clothes that fit. Consumers tend to blame themselves when the clothes do not fit their bodies, while our study points out that the industry is to blame as they do not produce clothing for all customers.

  9. The Ten Most Beautiful Experiments

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, George [The New York Times

    2010-10-20

    "Science in the 21st century has become industrialized. The experiments so often celebrated in the newspapers - sequencing the genome, proving the existence of the top quark, discovering a new planet by analyzing the wobble of a distant start - cost millions of dollars. They generate terabytes of data to be analyzed by supercomputers, calculating factories that spew out so much heat that they are equipped with cooling stacks and consume the energy of a small town. The experiments are carried out by research teams that have grown to the size of small corporations. But until very recently the most earth-shaking science came from individual pairs of hands. From a single mind confronting the unknown. The great experiments that mark the edges of our understanding were most often performed by one or two scientists and usually on a tabletop. Computation, if there was any, was carried out on paper or later with a slide rule. These experiments were designed and conducted with such straightforward elegance that they deserve to be called beautiful." (excerpt from the slide presentation accompanying the video)

  10. Beauty Meson Decays To Charmonium

    CERN Document Server

    Ershov, A V

    2001-01-01

    We study decays of beauty (B) mesons into the final states containing charmonium mesons. The data were collected by the CLEO experiment at the Cornell Electron Storage Ring from 1990 to 1999. First, we describe a technique that significantly improves the reconstruction efficiency for decays of J/ y and y (2S) mesons into a pair of leptons. This reconstruction method is used in all the analyses presented in this dissertation. Then we present a study of B decays to the χc 1 and χc2 charmonium states and compare our results with the predictions of different theoretical models of charmonium production. After that we report the first observation of the decay B → J/ y &phis;K, which is the first B meson decay requiring a creation of an additional ss¯ quark pair. Then we measure the B0 and B+ meson masses from B0 → y (′) K0S and B+ → y (′) K+ decays. The method employed eliminates the dominant systematic uncertainty associated w...

  11. Therapeutic efficacy of improved α-fetoprotein promoter-mediated tBid delivered by folate-PEI600-cyclodextrin nanopolymer vector in hepatocellular carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Hu, Bao-guang [Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR (Hong Kong); Department of Gastrointestinal Surgery, the Affiliated Hospital of Binzhou Medical University, Binzhou, Shandong (China); Liu, Li-ping [Department of Hepatobiliary and Pancreas Department of Hepatobiliary Surgery, the Second Clinical Medical College of Jinan University (Shenzhen People' s Hospital), Shenzhen, Guangdong Province (China); Chen, George G., E-mail: gchen@cuhk.edu.hk [Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR (Hong Kong); Ye, Cai Guo; Leung, Kevin K.C.; Ho, Rocky L.K.; Lin, Marie C.; Lai, Paul B.S. [Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR (Hong Kong)

    2014-06-10

    SNPs in human AFP promoter are associated with serum AFP levels in hepatocellular carcinoma (HCC), suggesting that AFP promoter variants may generate better transcriptional activities while retaining high specificity to AFP-producing cells. We sequenced human AFP promoters, cloned 15 different genotype promoters and tested their reporter activities in AFP-producing and non-producing cells. Among various AFP variant fragments tested, EA4D exhibited the highest reporter activity and thus was selected for the further study. EA4D was fused with tBid and coupled with nano-particle vector (H1) to form pGL3-EA4D-tBid/H1. pGL3-EA4D-tBid/H1 could express a high level of tBid while retain the specificity to AFP-producing cells. In a HCC tumor model, application of pGL3-EA4D-tBid/H1 significantly inhibited the growth of AFP-producing-implanted tumors with minimal side-effects, but had no effect on non-AFP-producing tumors. Furthermore, pGL3-EA4D-tBid/H1 could significantly sensitize HCC cells to sorafenib, an approved anti-HCC agent. Collectively, pGL3-EA4D-tBid/H1, a construct with the AFP promoter EA4D and the novel H1 delivery system, can specifically target and effectively suppress the AFP-producing HCC. This new therapeutic tool shows little toxicity in vitro and in vivo and it should thus be safe for further clinical tests. - Highlights: • The nano-particle vector H1 has advantages in mediating gene therapy construct pGL3-EA4D-tBid for HCC treatment. • pGL3-EA4D-tBid/H1, a construct with the AFP promoter EA4D, can specifically target the AFP-producing HCC. • pGL3-EA4D-tBid/H1effectively suppresses the proliferation and growth of AFP-producing HCC. • This novel pGL3-EA4D-tBid/H1 therapeutic tool shows little toxicity in vitro and in vivo.

  12. Therapeutic efficacy of improved α-fetoprotein promoter-mediated tBid delivered by folate-PEI600-cyclodextrin nanopolymer vector in hepatocellular carcinoma

    International Nuclear Information System (INIS)

    SNPs in human AFP promoter are associated with serum AFP levels in hepatocellular carcinoma (HCC), suggesting that AFP promoter variants may generate better transcriptional activities while retaining high specificity to AFP-producing cells. We sequenced human AFP promoters, cloned 15 different genotype promoters and tested their reporter activities in AFP-producing and non-producing cells. Among various AFP variant fragments tested, EA4D exhibited the highest reporter activity and thus was selected for the further study. EA4D was fused with tBid and coupled with nano-particle vector (H1) to form pGL3-EA4D-tBid/H1. pGL3-EA4D-tBid/H1 could express a high level of tBid while retain the specificity to AFP-producing cells. In a HCC tumor model, application of pGL3-EA4D-tBid/H1 significantly inhibited the growth of AFP-producing-implanted tumors with minimal side-effects, but had no effect on non-AFP-producing tumors. Furthermore, pGL3-EA4D-tBid/H1 could significantly sensitize HCC cells to sorafenib, an approved anti-HCC agent. Collectively, pGL3-EA4D-tBid/H1, a construct with the AFP promoter EA4D and the novel H1 delivery system, can specifically target and effectively suppress the AFP-producing HCC. This new therapeutic tool shows little toxicity in vitro and in vivo and it should thus be safe for further clinical tests. - Highlights: • The nano-particle vector H1 has advantages in mediating gene therapy construct pGL3-EA4D-tBid for HCC treatment. • pGL3-EA4D-tBid/H1, a construct with the AFP promoter EA4D, can specifically target the AFP-producing HCC. • pGL3-EA4D-tBid/H1effectively suppresses the proliferation and growth of AFP-producing HCC. • This novel pGL3-EA4D-tBid/H1 therapeutic tool shows little toxicity in vitro and in vivo

  13. Therapeutic ultrasound

    Energy Technology Data Exchange (ETDEWEB)

    Crum, Lawrence A [Center for Industrial and Medical Ultrasound, 1013 NE 40th Street, University of Washington, Seattle, WA 98105 (United States)

    2004-01-01

    The use of ultrasound in medicine is now quite commonplace, especially with the recent introduction of small, portable and relatively inexpensive, hand-held diagnostic imaging devices. Moreover, ultrasound has expanded beyond the imaging realm, with methods and applications extending to novel therapeutic and surgical uses. These applications broadly include: tissue ablation, acoustocautery, lipoplasty, site-specific and ultrasound mediated drug activity, extracorporeal lithotripsy, and the enhancement of natural physiological functions such as wound healing and tissue regeneration. A particularly attractive aspect of this technology is that diagnostic and therapeutic systems can be combined to produce totally non-invasive, imageguided therapy. This general lecture will review a number of these exciting new applications of ultrasound and address some of the basic scientific questions and future challenges in developing these methods and technologies for general use in our society. We shall particularly emphasize the use of High Intensity Focused Ultrasound (HIFU) in the treatment of benign and malignant tumors as well as the introduction of acoustic hemostasis, especially in organs which are difficult to treat using conventional medical and surgical techniques. (amum lecture)

  14. Therapeutic ultrasound

    International Nuclear Information System (INIS)

    The use of ultrasound in medicine is now quite commonplace, especially with the recent introduction of small, portable and relatively inexpensive, hand-held diagnostic imaging devices. Moreover, ultrasound has expanded beyond the imaging realm, with methods and applications extending to novel therapeutic and surgical uses. These applications broadly include: tissue ablation, acoustocautery, lipoplasty, site-specific and ultrasound mediated drug activity, extracorporeal lithotripsy, and the enhancement of natural physiological functions such as wound healing and tissue regeneration. A particularly attractive aspect of this technology is that diagnostic and therapeutic systems can be combined to produce totally non-invasive, imageguided therapy. This general lecture will review a number of these exciting new applications of ultrasound and address some of the basic scientific questions and future challenges in developing these methods and technologies for general use in our society. We shall particularly emphasize the use of High Intensity Focused Ultrasound (HIFU) in the treatment of benign and malignant tumors as well as the introduction of acoustic hemostasis, especially in organs which are difficult to treat using conventional medical and surgical techniques. (amum lecture)

  15. Combining universal beauty and cultural context in a unifying model of visual aesthetic experience.

    Science.gov (United States)

    Redies, Christoph

    2015-01-01

    In this work, I propose a model of visual aesthetic experience that combines formalist and contextual aspects of aesthetics. The model distinguishes between two modes of processing. First, perceptual processing is based on the intrinsic form of an artwork, which may or may not be beautiful. If it is beautiful, a beauty-responsive mechanism is activated in the brain. This bottom-up mechanism is universal amongst humans; it is widespread in the visual brain and responsive across visual modalities. Second, cognitive processing is based on contextual information, such as the depicted content, the intentions of the artist or the circumstances of the presentation of the artwork. Cognitive processing is partially top-down and varies between individuals according to their cultural experience. Processing in the two channels is parallel and largely independent. In the general case, an aesthetic experience is induced if processing in both channels is favorable, i.e., if there is resonance in the perceptual processing channel ("aesthetics of perception"), and successful mastering in the cognitive processing channel ("aesthetics of cognition"). I speculate that this combinatorial mechanism has evolved to mediate social bonding between members of a (cultural) group of people. Primary emotions can be elicited via both channels and modulate the degree of the aesthetic experience. Two special cases are discussed. First, in a subset of (post-)modern art, beauty no longer plays a prominent role. Second, in some forms of abstract art, beautiful form can be enjoyed with minimal cognitive processing. The model is applied to examples of Western art. Finally, implications of the model are discussed. In summary, the proposed model resolves the seeming contradiction between formalist perceptual approaches to aesthetic experience, which are based on the intrinsic beauty of artworks, and contextual approaches, which account for highly individual and culturally dependent aspects of aesthetics.

  16. Brain correlates of aesthetic judgment of beauty.

    Science.gov (United States)

    Jacobsen, Thomas; Schubotz, Ricarda I; Höfel, Lea; Cramon, D Yves V

    2006-01-01

    Functional MRI was used to investigate the neural correlates of aesthetic judgments of beauty of geometrical shapes. Participants performed evaluative aesthetic judgments (beautiful or not?) and descriptive symmetry judgments (symmetric or not?) on the same stimulus material. Symmetry was employed because aesthetic judgments are known to be often guided by criteria of symmetry. Novel, abstract graphic patterns were presented to minimize influences of attitudes or memory-related processes and to test effects of stimulus symmetry and complexity. Behavioral results confirmed the influence of stimulus symmetry and complexity on aesthetic judgments. Direct contrasts showed specific activations for aesthetic judgments in the frontomedian cortex (BA 9/10), bilateral prefrontal BA 45/47, and posterior cingulate, left temporal pole, and the temporoparietal junction. In contrast, symmetry judgments elicited specific activations in parietal and premotor areas subserving spatial processing. Interestingly, beautiful judgments enhanced BOLD signals not only in the frontomedian cortex, but also in the left intraparietal sulcus of the symmetry network. Moreover, stimulus complexity caused differential effects for each of the two judgment types. Findings indicate aesthetic judgments of beauty to rely on a network partially overlapping with that underlying evaluative judgments on social and moral cues and substantiate the significance of symmetry and complexity for our judgment of beauty.

  17. Hidden Beauty: Using a Poem by Jayne Cortez.

    Science.gov (United States)

    Statman, Mark

    1998-01-01

    Reproduces a poem about an urban landscape by Jayne Cortez and reflects on how students are willing to tackle its complexities and its ideas about beauty. Finds that the poem is effective for a discussion of beauty among students. (PA)

  18. The evolutionary psychology of facial beauty.

    Science.gov (United States)

    Rhodes, Gillian

    2006-01-01

    What makes a face attractive and why do we have the preferences we do? Emergence of preferences early in development and cross-cultural agreement on attractiveness challenge a long-held view that our preferences reflect arbitrary standards of beauty set by cultures. Averageness, symmetry, and sexual dimorphism are good candidates for biologically based standards of beauty. A critical review and meta-analyses indicate that all three are attractive in both male and female faces and across cultures. Theorists have proposed that face preferences may be adaptations for mate choice because attractive traits signal important aspects of mate quality, such as health. Others have argued that they may simply be by-products of the way brains process information. Although often presented as alternatives, I argue that both kinds of selection pressures may have shaped our perceptions of facial beauty.

  19. Hadroproduction characteristics of charm and beauty

    International Nuclear Information System (INIS)

    In this article the authors review the present status of their knowledge on the hadroproduction characteristics of charm and beauty. During a brief description of the properties of all charm and beauty particles reportedly observed in hadron-hadron experiments they discuss the strengths and weaknesses of the various experimental techniques. In particular they emphasise the quantitative problems associated with nuclear target experiments and show the progress that is being made in understanding the A-dependence problem. Focussing on charm cross sections the authors see that the data are becoming sufficiently good to give us a reliable and coherent picture which provides a serious test of the QCD fusion model. This same fusion model is then used with existing beauty cross section determinations to make some extrapolations. Finally, a few remaining puzzles and curiosities are underlined

  20. On the Beautiful and the Ugly

    Directory of Open Access Journals (Sweden)

    Herman Parret

    2011-01-01

    Full Text Available Classical aesthetics sees the experience of the beautiful as an anthropological necessity. But, in fact, the beautiful is rather the central category designating classical art, and one can question the relevance of this category considering contemporary art. The reference term most frequently used for contemporary art is interesting: works of art solicit the interests of my faculties (the cognitive-intellectual, the pragmatic community-oriented moral, the affective aesthetic faculties. It is interesting to notice that the categories of the beautiful and the ugly have an axiological-moral value. It looks as if the qualities of contemporary art works are judged according to the intensity of the impact on the interests of our faculties. It reveals important, in this respect, to distinguish the ugly from the sublime and the monstrous. Kant’s Third Critique is of some importance in defining these categories.

  1. On the Beauty in Keats’s Ode to Autumn

    Institute of Scientific and Technical Information of China (English)

    谭凯

    2011-01-01

    Keats’s poems are famous for beauty,and Ode to Autumn is generally regarded as one of his most beautiful poems.In this ode,Keats presents a vivid picture of the harvesting autumn,in which many forms of beauty can be captured.The present paper attempts to conduct an analysis of the beauty in Keats’s Ode to Autumn,hopefully it could help readers better understand Keats and his works.

  2. Fixed Target Beauty Physics Experimental Programs

    International Nuclear Information System (INIS)

    The current and near term future fixed target physics efforts in observing particles with open beauty are reviewed. This includes a compilation of the non-observation upper limits and the observation of both upsilon and b-states. A short discussion of the theoretical predictions for the hadro-produced beauty pairs is included. The major part of this review is devoted to the techniques and tricks employed, a survey of the current and proposed experiments. A personal summary of the experimental prospects concludes this report. 28 refs., 26 figs

  3. Beautiful skin%美丽肌肤

    Institute of Scientific and Technical Information of China (English)

    胡敏

    2012-01-01

    介绍了皮肤皱纹生成的机理,抗皱有效成分、作用机理以及皮肤的抗衰老护理。介绍了一些美容食品、抗老化美容成分以及最具潜力的原料来源。%The mechanism of skin wrinkle formation,the active ingredients of anti-aging,the mechanism of action as well as skin anti-aging care were introduced here.Some beautiful foods,anti-aging beautiful ingredients and the most interesting source of feed were also related.

  4. Walking in Beauty: An American Indian Perspective on Social Justice

    Science.gov (United States)

    Eason, Evan Allen; Robbins, Rockey

    2012-01-01

    The purpose of this article is to introduce "walking in beauty," an American Indian spiritual perspective related to social justice that emphasizes beauty, harmony, connectedness/unity of experience, and imagination. Walking in beauty includes 3 processes: embodiment, creativity, and appreciation of the sublime. Recommendations are offered for…

  5. 75 FR 33763 - Beauty and Cosmetics Trade Mission to India

    Science.gov (United States)

    2010-06-15

    ... International Trade Administration Beauty and Cosmetics Trade Mission to India AGENCY: International Trade... Beauty and Cosmetics Trade Mission to India (New Delhi, Mumbai and Bangalore), November 15-19, 2010. Led.... The cosmetics/beauty industry is one of the booming retail sectors in India with very strong...

  6. 75 FR 21595 - Beauty and Cosmetics Trade Mission to India

    Science.gov (United States)

    2010-04-26

    ... International Trade Administration Beauty and Cosmetics Trade Mission to India AGENCY: International Trade... Beauty and Cosmetics Trade Mission to India (New Delhi, Mumbai and Bangalore), November 15-19, 2010. Led... Indian market. The cosmetics/ beauty industry is one of the booming retail sectors in India with...

  7. Explosions in Majestic Spiral Beauties

    Science.gov (United States)

    2004-12-01

    Images of beautiful galaxies, and in particular of spiral brethren of our own Milky Way, leaves no-one unmoved. It is difficult indeed to resist the charm of these impressive grand structures. Astronomers at Paranal Observatory used the versatile VIMOS instrument on the Very Large Telescope to photograph two magnificent examples of such "island universes", both of which are seen in a southern constellation with an animal name. But more significantly, both galaxies harboured a particular type of supernova, the explosion of a massive star during a late and fatal evolutionary stage. The first image (PR Photo 33a/04) is of the impressive spiral galaxy NGC 6118 [1], located near the celestial equator, in the constellation Serpens (The Snake). It is a comparatively faint object of 13th magnitude with a rather low surface brightness, making it pretty hard to see in small telescopes. This shyness has prompted amateur astronomers to nickname NGC 6118 the "Blinking Galaxy" as it would appear to flick into existence when viewed through their telescopes in a certain orientation, and then suddenly disappear again as the eye position shifted. There is of course no such problem for the VLT's enormous light-collecting power and ability to produce sharp images, and this magnificent galaxy is here seen in unequalled detail. The colour photo is based on a series of exposures behind different optical filters, obtained with the VIMOS multi-mode instrument on the 8.2-m VLT Melipal telescope during several nights around August 21, 2004. About 80 million light-years away, NGC 6118 is a grand-design spiral seen at an angle, with a very small central bar and several rather tightly wound spiral arms (it is classified as of type "SA(s)cd" [2]) in which large numbers of bright bluish knots are visible. Most of them are active star-forming regions and in some, very luminous and young stars can be perceived. Of particular interest is the comparatively bright stellar-like object situated directly

  8. Old age – „how beautiful to be yourself”

    Directory of Open Access Journals (Sweden)

    Ilona Zakowicz

    2011-12-01

    Full Text Available In every given period one can observe different attitudes towards old age, death and the elderly, which are shown through varied stances and ideas about this specific period of human life. The reality of the XXI century often regarded as “vision-centric” is dominated by the cult of beauty and youth which creates increasingly demanding requirements, related mainly to the attractiveness of appearance, of the body – especially the one belonging to the elderly. The increase in the number of senior citizens compared to the rest of the society that can be witnessed nowadays leads to the elderly being a more carefully examined social group. Mediated by the media discourse the images of the elderly are becoming more common and therefore the author’s attempt at reconstructing the postmodern strategy of the rendering of late adulthood seems to be an interesting and important topic to consider

  9. Beauty meson decays to charmonium

    Science.gov (United States)

    Ershov, Alexey Valerievich

    2001-10-01

    We study decays of beauty (B) mesons into the final states containing charmonium mesons. The data were collected by the CLEO experiment at the Cornell Electron Storage Ring from 1990 to 1999. First, we describe a technique that significantly improves the reconstruction efficiency for decays of J/ y and y (2S) mesons into a pair of leptons. This reconstruction method is used in all the analyses presented in this dissertation. Then we present a study of B decays to the χc 1 and χc2 charmonium states and compare our results with the predictions of different theoretical models of charmonium production. After that we report the first observation of the decay B --> J/ y φK, which is the first B meson decay requiring a creation of an additional ss¯ quark pair. Then we measure the B0 and B+ meson masses from B0 --> y (') K0S and B+ --> y (') K+ decays. The method employed eliminates the dominant systematic uncertainty associated with the previous B meson mass measurements at the e+e- colliders and results in a significant improvement in precision. After that we present a study of three B0 decay modes useful for time-dependent CP asymmetry measurements. In this study we reconstruct B0 --> J/ y K0S , B0 --> χc 1 K0S , and B0 --> J/ y π0 decays. The latter two decay modes are observed for the first time. We describe a K0S --> π0π0 detection technique and its application to the reconstruction of the decay B 0 --> J/ y K0S . Then we present a sensitivity study for the measurement of the mixing-induced CP violation in the neutral B meson system (parameter sin 2β) at CLEO using the method that requires a measurement of the decay time of only one meson in a B0overline B0 pair. Finally, we search for direct CP violation in decays B+/- --> J/ y K+/- and B +/- --> y (2S) K+/- . The results of this search are consistent with the Standard Model expectations and provide the first experimental test of the assumption that direct CP violation is negligible in B --> y (') K decays.

  10. Beauty Clinic Services and Using of Cosmetic for Beauty Clinic Attendees at Jakarta, Indonesia

    OpenAIRE

    raharni budiarto

    2014-01-01

    Cosmetic is one of pharmaceuticals preparation, with the vigorous cosmetic advertising in print media, electronic media or internet, communities are faced with cosmetics advertising, in which mostly are offering for skin care, especially women to get the skin whiter and brighter. Cosmetic advertising based on Ministry of Health regulation no. 386/Menkes/SK/1994. The objective of this study was to know the beauty clinic services and using of cosmetic for beauty clinic attendees and affecting f...

  11. Beauty and Brains: Detecting Anomalous Pattern Co-Occurrences

    OpenAIRE

    Bertens, Roel; Vreeken, Jilles; Siebes, Arno

    2015-01-01

    Our world is filled with both beautiful and brainy people, but how often does a Nobel Prize winner also wins a beauty pageant? Let us assume that someone who is both very beautiful and very smart is more rare than what we would expect from the combination of the number of beautiful and brainy people. Of course there will still always be some individuals that defy this stereotype; these beautiful brainy people are exactly the class of anomaly we focus on in this paper. They do not posses intri...

  12. Beauty as Fit: A Metaphor in Mathematics?

    Science.gov (United States)

    Raman, Manya; Öhman, Lars-Daniel

    2013-01-01

    Beauty, which plays a central role in the practice of mathematics (Sinclair 2002), is almost absent in discussions of school mathematics (Dreyfus and Eisenberg 1986). This is problematic, because students will decide whether or not to continue their studies in mathematics without having an accurate picture of what the subject is about. In order to…

  13. The Beautiful Physics of LHC Run 2

    CERN Document Server

    AUTHOR|(CDS)2108556

    2015-01-01

    Run 2 of the LHC offers some beautiful prospects for new physics, including flavour physics as well as more detailed studies of the Higgs boson and searches for new physics beyond the Standard Model (BSM). One of the possibilities for BSM physics is supersymmetry, and flavour physics plays various important r\\^oles in constraining supersymmetric models.

  14. Open Charm and Beauty Production at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Behnke, Olaf [DESY, Notkestrasse 85, 22607 Hamburg (Germany)

    2012-01-15

    A review is provided of open charm and beauty production at HERA and its description by perturbative QCD (pQCD). Four years after the end of the data taking there is still a steady flow of new charm and beauty results from HERA. Among the results reported here are the first combined H1 and ZEUS measurements on the contribution from charm production to deep inelastic scattering (DIS), represented by the structure function F{sub 2}{sup cc{sup {sup M{sup a{sup c{sup r{sup o{sup n{sup }}}}}}}}}, as well as new precise results on the corresponding structure function for beauty production, F{sub 2}{sup bb{sup {sup M{sup a{sup c{sup r{sup o{sup n{sup }}}}}}}}}. Furthermore the situation of charm and beauty production in the photoproduction kinematic regime is reviewed. Since it is a related field also the first hadroproduction results from LHC are presented. A brief outlook is given on open heavy flavour prospects at possible future ep colliders, with a focus on the LHeC.

  15. Rare beauty and charm decays at LHCb

    CERN Document Server

    Puig Navarro, A

    2013-01-01

    Flavour changing neutral current decays of heavy flavoured hadrons are suppressed in the Standard Model and can be used to search for new physics contributions. We report a summary of the latest results from the LHCb collaboration on rare decays of beauty and charm hadrons.

  16. Rare Beauty and Charm Decays at LHCb

    CERN Document Server

    Puig, Albert

    2013-01-01

    Flavour changing neutral current decays of heavy flavoured hadrons are suppressed in the Standard Model and can be used to search for new physics contributions. We report a summary of the latest results from the LHCb collaboration on rare decays of beauty and charm hadrons.

  17. Mathematicians in Schools: Uncovering Maths' Beautiful Secrets

    Science.gov (United States)

    Welch, Bronwyn

    2016-01-01

    Mathematics professionals are working with teachers revealing the reality and beauty that happens in the world of math and to show that this is essentially a "human endeavour," embedded in much of what people do and the ways in which they think. In this article, the author shares vignettes of primary classes working with mathematicians…

  18. Poplus Diversifolia:The Most Beautiful Tree

    Institute of Scientific and Technical Information of China (English)

    ZhanHua

    2004-01-01

    Populus diversifolia,an old and rare tree species,is an only tree variety that can naturally grow into forest in Xinjiang's deserts.It is called "Tokolako"in the Uigur language,meaning"the most beautiful tree".Its extraordinary resistance to drought,sand wind and sanitization enables it to thrive in deserts and gains it repute

  19. [Study of hyperons and beauty particles

    International Nuclear Information System (INIS)

    The proposed research program is to study the production and decay properties of the hyperons and the beauty hadrons at Fermilab. Since the project was approved in 1989, a lot of progress has been made. This report is a summary of the achievements

  20. Beauty baryon decays: a theoretical overview

    International Nuclear Information System (INIS)

    I overview the theoretical status and recent progress on the calculations of beauty baryon decays focusing on the QCD aspects of the exclusive semi-leptonic Λb → pℓμ decay at large recoil and theoretical challenges of radiative and electro-weak penguin decays Λb → Λγ,Λℓ+ℓ−

  1. Why Beautiful People Are More Intelligent

    Science.gov (United States)

    Kanazawa, Satoshi; Kovar, Jody L.

    2004-01-01

    Empirical studies demonstrate that individuals perceive physically attractive others to be more intelligent than physically unattractive others. While most researchers dismiss this perception as a ''bias'' or ''stereotype,'' we contend that individuals have this perception because beautiful people indeed "are" more intelligent. The conclusion that…

  2. Beautiful Minds—For How Long.

    Directory of Open Access Journals (Sweden)

    Lori Marino

    2008-07-01

    Full Text Available Lori Marino reviews the new bookBeautiful Minds, which investigates the "parallel lives" of primates and cetaceans and argues that despite the evolutionary distance of these large-brained mammals, they nevertheless share a capacity for complex communication and social behavior, representing a striking example of convergence in intelligence.

  3. The Beautiful Physics of LHC Run 2

    OpenAIRE

    Ellis, John

    2014-01-01

    Run 2 of the LHC offers some beautiful prospects for new physics, including flavour physics as well as more detailed studies of the Higgs boson and searches for new physics beyond the Standard Model (BSM). One of the possibilities for BSM physics is supersymmetry, and flavour physics plays various important r\\^oles in constraining supersymmetric models.

  4. Beautiful mass predictions from scalar lattice QCD

    Energy Technology Data Exchange (ETDEWEB)

    Samuel, S.; Moriarty, K.J.M.

    1986-07-31

    Scalar lattice QCD methods are used to accurately predict the masses of hadrons with beauty, that is, states which contain a b quark. These states have not yet been seen in the laboratory. The accuracy of the predictions (approx.=25 MeV) make the calculation a good test of lattice methods as well as providing useful guidance for experimentalists.

  5. Beautiful Minds—For How Long

    OpenAIRE

    Lori Marino

    2008-01-01

    Lori Marino reviews the new bookBeautiful Minds, which investigates the "parallel lives" of primates and cetaceans and argues that despite the evolutionary distance of these large-brained mammals, they nevertheless share a capacity for complex communication and social behavior, representing a striking example of convergence in intelligence.

  6. Miss International Beauty Pageant in China

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ The 47th Miss International Beauty Pageant, jointly sponsored by China Youth Concern Committee for the Advancement of Health and Physical Culture Development, International Culture Association, Kessles Paris, International Culture Exchange Organization,and co-organized by Beijing Kessles International Culture Media Co., Ltd., will be held in Beijing, China, according to the press conference on March 21.

  7. Natural Tendency towards Beauty in Humans: Evidence from Binocular Rivalry.

    Directory of Open Access Journals (Sweden)

    Ce Mo

    Full Text Available Although human preference for beauty is common and compelling in daily life, it remains unknown whether such preference is essentially subserved by social cognitive demands or natural tendency towards beauty encoded in the human mind intrinsically. Here we demonstrate experimentally that humans automatically exhibit preference for visual and moral beauty without explicit cognitive efforts. Using a binocular rivalry paradigm, we identified enhanced gender-independent perceptual dominance for physically attractive persons, and the results suggested universal preference for visual beauty based on perceivable forms. Moreover, we also identified perceptual dominance enhancement for characters associated with virtuous descriptions after controlling for facial attractiveness and vigilance-related attention effects, which suggested a similar implicit preference for moral beauty conveyed in prosocial behaviours. Our findings show that behavioural preference for beauty is driven by an inherent natural tendency towards beauty in humans rather than explicit social cognitive processes.

  8. Natural Tendency towards Beauty in Humans: Evidence from Binocular Rivalry.

    Science.gov (United States)

    Mo, Ce; Xia, Tiansheng; Qin, Kaixin; Mo, Lei

    2016-01-01

    Although human preference for beauty is common and compelling in daily life, it remains unknown whether such preference is essentially subserved by social cognitive demands or natural tendency towards beauty encoded in the human mind intrinsically. Here we demonstrate experimentally that humans automatically exhibit preference for visual and moral beauty without explicit cognitive efforts. Using a binocular rivalry paradigm, we identified enhanced gender-independent perceptual dominance for physically attractive persons, and the results suggested universal preference for visual beauty based on perceivable forms. Moreover, we also identified perceptual dominance enhancement for characters associated with virtuous descriptions after controlling for facial attractiveness and vigilance-related attention effects, which suggested a similar implicit preference for moral beauty conveyed in prosocial behaviours. Our findings show that behavioural preference for beauty is driven by an inherent natural tendency towards beauty in humans rather than explicit social cognitive processes.

  9. Natural Tendency towards Beauty in Humans: Evidence from Binocular Rivalry.

    Science.gov (United States)

    Mo, Ce; Xia, Tiansheng; Qin, Kaixin; Mo, Lei

    2016-01-01

    Although human preference for beauty is common and compelling in daily life, it remains unknown whether such preference is essentially subserved by social cognitive demands or natural tendency towards beauty encoded in the human mind intrinsically. Here we demonstrate experimentally that humans automatically exhibit preference for visual and moral beauty without explicit cognitive efforts. Using a binocular rivalry paradigm, we identified enhanced gender-independent perceptual dominance for physically attractive persons, and the results suggested universal preference for visual beauty based on perceivable forms. Moreover, we also identified perceptual dominance enhancement for characters associated with virtuous descriptions after controlling for facial attractiveness and vigilance-related attention effects, which suggested a similar implicit preference for moral beauty conveyed in prosocial behaviours. Our findings show that behavioural preference for beauty is driven by an inherent natural tendency towards beauty in humans rather than explicit social cognitive processes. PMID:26930202

  10. Natural Tendency towards Beauty in Humans: Evidence from Binocular Rivalry

    Science.gov (United States)

    Mo, Lei

    2016-01-01

    Although human preference for beauty is common and compelling in daily life, it remains unknown whether such preference is essentially subserved by social cognitive demands or natural tendency towards beauty encoded in the human mind intrinsically. Here we demonstrate experimentally that humans automatically exhibit preference for visual and moral beauty without explicit cognitive efforts. Using a binocular rivalry paradigm, we identified enhanced gender-independent perceptual dominance for physically attractive persons, and the results suggested universal preference for visual beauty based on perceivable forms. Moreover, we also identified perceptual dominance enhancement for characters associated with virtuous descriptions after controlling for facial attractiveness and vigilance-related attention effects, which suggested a similar implicit preference for moral beauty conveyed in prosocial behaviours. Our findings show that behavioural preference for beauty is driven by an inherent natural tendency towards beauty in humans rather than explicit social cognitive processes. PMID:26930202

  11. El ojo hermoso The beautiful eye

    Directory of Open Access Journals (Sweden)

    O. M. Ramírez

    2007-06-01

    Full Text Available Como cirujanos estéticos siempre nos esforzamos por alcanzar resultados hermosos que sean agradables a los sentidos. Esto es particularmente cierto en el terreno del rejuvenecimiento periorbitario. Según la estadística de la Sociedad Americana de Cirujanos Plásticos la blefaroplastia estética es uno de los procedimientos mas frecuentes y su frecuencia va en aumento tanto en hombres como en mujeres. El rejuvenecimiento periorbitario adecuado debería restaurar la percepción interior del paciente respecto a belleza y juventud de sus ojos, así como proporcionar un aspecto externo que sea "estético" o agradable a los sentidos. Para lograr este objetivo, se requiere una comprensión de la estética facial, tanto en términos subjetivos como objetivos. Los investigadores han demostrado que la percepción del atractivo o la belleza en la cara de un individuo es relativamente constante entre observadores independientes, desafiando el dicho popular de que "la belleza está en el ojo del espectador." Presentamos una actualización del tema y una amplia iconografía. La información recogida de la literatura y de años experiencia clínica debería permitir al lector desarrollar una mayor sensibilidad estética, para obtener resultados óptimos en el rejuvenecimiento periorbitario.As aesthetic surgeons we are always striving to achieve beautiful results that are pleasurable to the senses. This is particularly certain in the land of the periorbital rejuvenation. According to the statistics of the American Society of Plastic Surgeons, aesthetic blepharoplasty is one of the procedures most commonly performed and goes in increase its so much frequency in men as in women. Successful periorbital rejuvenation should restore the patient"s inner sense of beauty and youthfulness as well as provide an outward appearance that is ‘aesthetic" or pleasurable to the senses. To accomplish this lofty goal, the aesthetic surgeon must strive to create "the beautiful

  12. ICTR-PHE Public Talk | Physics is beautiful and useful by Ugo Amaldi | 11 February

    CERN Multimedia

    2014-01-01

    In the framework of the International Conference on Translational Research in Radiation Oncology – Physics for Health in Europe (ICTR-PHE, see here), which will take place at the Geneva International Conference Centre from 10 to 14 February 2014, the public is invited to attend an exceptional talk:   Physics is beautiful and useful by Ugo Amaldi Tuesday 11 February 2014, 6.30 p.m. Geneva International Conference Centre 17, rue de Varembé, Geneva *The talk will be in English with simultaneous translation into French* Abstract: The year 2014 marks the 60th anniversary of CERN and of the first cancer treatment with protons done at Berkeley. This is no coincidence: indeed, the beauty of particle physics has always gone hand in hand with useful applications. These “useful” activities follow from the technical developments in particle accelerators and radiation detectors that have brought about the discoveries of neutral currents (1973), of its mediator the...

  13. Charm and beauty production at RHIC

    Energy Technology Data Exchange (ETDEWEB)

    Kabana, Sonia [Laboratoire de Physique Subatomique et des Technologies Associees (SUBATECH), Ecole des Mines, 4 rue Alfred Kastler, 44307 Nantes (France)

    2011-01-15

    We review selected highlights on charm and beauty production at RHIC from p+p, d+Au and A+A collisions at {radical}(s{sub NN})=200GeV, and compare them to model calculations. We focus on two particular issues, jet quenching and quarkonia. Anomalous energy loss (jet quenching) of quarks passing through the dense and hot matter built in heavy ion collisions is one of the outstanding discoveries made at RHIC. This phenomenon allows for an estimate of the initial gluon density. Furthermore, color screening of hidden charm and beauty states is a key signature of the QCD phase transition, allowing an estimate of the initial temperature. We present results on the flavour dependence of jet quenching. Heavy flavour production in A+A as compared to p+p collisions will be discussed for open and hidden charm.

  14. Hidden Beauty in Twisted Viking Neck Rings

    CERN Document Server

    Olsen, Kasper

    2010-01-01

    Many hoards found in Ireland, Scotland, Orkney Islands, and Scandinavia demonstrate the vikings ability to fabricate beautiful arm and neck rings of twisted silver and gold rods. Characteristic for such rings is the uniform appearance of the twisted pattern along the length of the arm ring, as well as from one arm ring to another, also when found at distant geographical locations. How can the appearance of the twisted wires be so perfectly repetitive? We demonstrate that the answer is that the vikings utilized a self-forming motif: The pattern arises from a twisting of the wires to a maximally rotated configuration. That is why the twist patterns in these arm and neck rings are beautiful, repetitive, and universal.

  15. Non-leptonic decays of beauty decays

    CERN Document Server

    Bigi, Ikaros I; Shifman, M; Uraltsev, N; Vainshtein, A I

    1994-01-01

    "Anyone who keeps the ability to see beauty never grows old" (Franz Kafka). In the last few years considerable progress has been achieved in our understanding of the decays of heavy flavour hadrons. One can now calculate inclusive transition rates in QCD proper through an expansion in inverse powers of the heavy flavour quark mass without recourse to phenomenological assumptions. The non-perturbative contributions are treated systematically in this way; they are found to produce corrections of order a few percent in beauty decays, i.e. typically somewhat smaller than the perturbative corrections. One finds, among other things: (a) The lifetime of $B^-$ mesons is predicted to be longer than that of $B^0$ mesons by several percent. (b) The QCD prediction for the semileptonic branching ratio of $B$ mesons appears to exceed present experimental values.

  16. Truth, virtue and beauty: midwifery and philosophy.

    Science.gov (United States)

    Parker, J M; Gibbs, M

    1998-09-01

    In this paper, we outline three moments in the history of Western philosophy--Classical Greek, Modernity, Postmodernity--and the ways in which issues of truth, virtue and beauty have been understood within these philosophical formations. In particular, we investigate the ways in which notions of truth, virtue and beauty influenced the orthodoxy of birthing practices at these different moments. Finally, we examine current, critical reflections on the role of the intellectual in postmodern society and use these reflections as a heuristic for understanding the role of the contemporary midwife. We suggest that midwifery must reconcile two divergent demands. The first is to mobilise the positive, instrumental benefits of Western medical science to improve mortality and morbidity outcomes. The second is to remain sensitive to the cultural and social meanings attached to traditional birthing practices and to understand the roles these play in the well-being of mother and child.

  17. The Hidden Beauty in Biomedical Imaging.

    Science.gov (United States)

    Barker, Norman; Iacobuzio-Donahue, Christine

    2015-01-01

    Caretakers, researchers and photographers working in a busy academic settings, every day are faced with images that are awe-inspiring for their beauty and for the terror they may represent to patients suffering from disease. Beauty in this context is a relative term. It may be seen as the delicate lacework of cells within the normal human brain reminiscent of a Jackson Pollack masterpiece, or the multitude of colors and textures formed by fungal organisms in a microbiology lab. Herein lies the juxtaposition image makers seek to represent. When contemplated in isolation, each represents a visually interesting image. However, when viewed with an awareness of the context in which the image was obtained, each image takes on the ability to evoke an alternative human emotion.

  18. China's Most Beautiful Books

    Institute of Scientific and Technical Information of China (English)

    WuLiang

    2005-01-01

    “China's Most Beautiful Books 2004”, an annual national award for books' graphic design, came out in Shanghai in January, 2005. Twenty-four publications won the titles and were recommended to participate in “The Most Beautiful Books of the World 2005” competition which will be held in Leibzig, Germany. The award winners included both best sellers with simplistic design such as “Us Three” and “Niu Niu: A Father's Notes”, and thread-bound traditional books such as “Ma De's Painting Album”, “Nanmu Carvings in West of Hunan Province”, “Watch the Three Gorges” and “Culture of Southeast China: Key Words”。

  19. Beautiful seasons of Pan’an

    Institute of Scientific and Technical Information of China (English)

    季陈熙; 陈妙芳

    2015-01-01

    I.m from Pan an,It s a small town of Zhejiang.Do you know?It s the most beautiful palce in my heart.Panan is a bes place to live.In Pan an,The water is clean,the trees are green,the air is very fresh.In an increasingly harsh environment,PM2.5 is also rampant worldwide,Pan an is getting more and more popula

  20. Sleeping Beauty: Kleine–Levin Syndrome

    OpenAIRE

    Mudgal, Soumiya; Jiloha, R. C.; Kandpal, Manish; Das, Aparna,

    2014-01-01

    Kleine–Levin syndrome (KLS) alias sleeping beauty syndrome, is a rare sleep disorder. Clinically presenting as episodes of hypersomnolence, behavioral and cognitive disturbances, hyperphagia and hypersexuality. KLS may have an idiopathic onset or may be precipitated by neurological event or infection. Until date, no definite underlying cause is established and neither there are any definitive management guidelines. It remains a diagnosis of exclusion after other psychiatric and neurological c...

  1. The 2012 Interferometric Imaging Beauty Contest

    OpenAIRE

    Baron, Fabien; Cotton, William D.; Lawson, Peter R.; Ridgway, Steve T.; Aarnio, Alicia; Monnier, John D.; Hofmann, Karl-Heinz; Schertl, Dieter; Weigelt, Gerd; Thiébaut, Eric; Soulez, Férréol; Mary, David; Millour, Florentin; Vannier, Martin; Young, John

    2012-01-01

    We present the results of the fifth Interferometric Imaging Beauty Contest. The contest consists in blind imaging of test data sets derived from model sources and distributed in the OIFITS format. Two scenarios of imaging with CHARA/MIRC-6T were offered for reconstruction: imaging a T Tauri disc and imaging a spotted red supergiant. There were eight different teams competing this time: Monnier with the software package MACIM; Hofmann, Schertl and Weigelt with IRS; Thi\\'ebaut and Soulez with M...

  2. Hidden Beauty in Twisted Viking Neck Rings

    OpenAIRE

    Olsen, Kasper; Bohr, Jakob

    2010-01-01

    Many hoards found in Ireland, Scotland, Orkney Islands, and Scandinavia demonstrate the vikings ability to fabricate beautiful arm and neck rings of twisted silver and gold rods. Characteristic for such rings is the uniform appearance of the twisted pattern along the length of the arm ring, as well as from one arm ring to another, also when found at distant geographical locations. How can the appearance of the twisted wires be so perfectly repetitive? We demonstrate that the answer is that th...

  3. The neural correlates of beauty comparison

    OpenAIRE

    Kedia, Gayannée; Mussweiler, Thomas; Mullins, Paul; Linden, David E. J.

    2013-01-01

    Beauty is in the eye of the beholder. How attractive someone is perceived to be depends on the individual or cultural standards to which this person is compared. But although comparisons play a central role in the way people judge the appearance of others, the brain processes underlying attractiveness comparisons remain unknown. In the present experiment, we tested the hypothesis that attractiveness comparisons rely on the same cognitive and neural mechanisms as comparisons of simple nonsocia...

  4. Glumpy : Fast, scalable and beautiful scientific visualization

    OpenAIRE

    Rougier, Nicolas P.

    2015-01-01

    Glumpy is a python library for scientific visualization that is both fast, scalable and beautiful. Glumpy offers an intuitive interface between numpy and modern OpenGL. Numpy arrays are tracked automatically such that any change on the CPU is reflected automatically on the GPU, making the integration seamless. glumpy provides more than 100 examples showing how to achieve this or that visualization, such as antialiasing, text rendering, isolines computation, image filtering, cartographic proje...

  5. Productivity or Discrimination? Beauty and the Exams

    OpenAIRE

    Giam Pietro Cipriani; Angelo Zago

    2005-01-01

    Do good looks make people more productive? An impact of looks on earnings has been found in the empirical literature: plain people earn less than average-looking people who earn less than the good-looking. However, an important question remains unanswered: is the impact of beauty due to pure discrimination or productivity? We provide evidence against the hypothesis of Becker-type discrimination stemming from tastes and in favor of productivity-related discrimination.

  6. ''Beauty of Wholeness and Beauty of Partiality.'' New Terms Defining the Concept of Beauty in Architecture in Terms of Sustainability and Computer Aided Design

    Science.gov (United States)

    Farid, Ayman A.; Zaghloul, Weaam M.; Dewidar, Khaled M.

    2014-01-01

    The great shift in sustainability and computer aided design in the field of architecture caused a remarkable change in the architecture philosophy, new aspects of beauty and aesthetic values are being introduced, and traditional definitions for beauty cannot fully cover this aspects, which causes a gap between; new architecture works criticism and…

  7. Lifetimes of charm and beauty hadrons

    Science.gov (United States)

    Bellini, G.; Bigi, I. I.; Dornan, P. J.

    1997-10-01

    Major breakthroughs have been achieved in the determination of the lifetimes of charm and beauty hadrons. Much larger data samples than previously have become available and new experimental devices and techniques have been developed and employed. The lifetimes of all weakly decaying singly charmed hadrons have been measured, some with an accuracy of a few percent. The difference in the shortest lifetime - τ(Ω c) - and the longest one - τ( D+) - is given by a factor of close to ten. The experimental status of beauty lifetimes, while less complete, has still reached a new level of quality and is now better than 5% for the commoner states. New theoretical tools, based mainly on heavy quark expansions, have been developed; they incorporate as well as transcend earlier phenomenological descriptions. The observed pattern in the charm lifetime ratios is reproduced in a semi-quantitative manner as well as could be expected; as far as the beauty lifetime ratios are concerned some problems may well be emerging. The maturity level achieved in the measurements bodes quite well for future challenges where reliable and efficient tracking of the decay vertices will be crucial.

  8. The Most Beautiful Heart%最美丽的心

    Institute of Scientific and Technical Information of China (English)

    章纯

    2010-01-01

    @@ One day a young man was standing in the middle of the town proclaiming that he had the most beautiful heart in the whole valley.A large crowd gathered and they all admired his heart for it was perfect.There was not a mark or a flaw in it.Yes,they all agreed it truly was the most beautiful heart they had ever seen.The young man was very proud and boasted1 more loudly about his beautiful heart.

  9. A hyperactive sleeping beauty transposase enhances transgenesis in zebrafish embryos

    OpenAIRE

    Lardelli Michael; Newman Morgan

    2010-01-01

    Abstract Background Transposons are useful molecular tools for transgenesis. The 'sleeping beauty' transposon is a synthetic member of the Tc1/mariner transposon family. Davidson et al. (2003) previously described a vector for zebrafish transgenesis consisting of the inverted repeats of 'sleeping beauty' flanking the gene to be transposed. Subsequently, there have been attempts to enhance the transpositional activity of 'sleeping beauty' by increasing the activity of its transposase. Recently...

  10. The prostitute's allure: Examining returns to beauty, productivity and discrimination

    OpenAIRE

    Arunachalam, Raj; Shah, Manisha

    2010-01-01

    We estimate the earnings premium for beauty in an occupation where returns to physical attractiveness are likely to be important: commercial sex work. In the commercial sex market, perhaps more so than any other sector in the labor market, the beauty premium should be at the extreme due to the intimate interpersonal relationships required with clients. Therefore, the commercial sex sector provides the cleanest test for whether the beauty premium is driven solely by productivity. Somewhat surp...

  11. Beautiful, but also potentially invasive

    Directory of Open Access Journals (Sweden)

    Lipták Boris

    2015-03-01

    Full Text Available Introduction of non-indigenous exotic species to new areas, where they may establish viable populations and become invasive, is a considerable problem in the protection of nature worldwide, as these species may alter the indigenous species population structure and potentially even decrease the biodiversity. The European fauna underwent through major negative changes on the continent and nowadays, it experiences another new treat, represented by the expanding aquarium pet trade, and with it, associated species (and disease introductions. Exotic freshwater crustaceans are one of the taxa widely incorporated in the business, counting a remarkable number of species. Recent records of the exotic marbled crayfish or Marmorkrebs (Procambarus fallax f. virginalis in German in open ecosystems in Slovakia pointed to human-mediated introductions associated with aquarium pet trade in the country. In this regard, a study of the aquarium pet trade both in expositions and shops and online was assessed. Several crustacean taxa are available both in pet trade exhibitions and online through the Internet. Altogether 26 different species were identified in the aquarium trade in Slovakia. These are Procambarus fallax f. virginalis, P. clarkii, P. alleni, Cherax quadricarinatus, C. destructor, C. holthuisi, C. peknyi, Cambarellus patzcuarensis and C. diminutus occurring in the aquarium pet trade in Slovakia (n = 9. Procambarus fallax f. virginalis, P. clarkii and C. patzuarensis are the most common in this regard. There is also a quantity of other related taxa in the aquarium pet trade in Slovakia, mainly Caridina spp. (n = 5, Neocaridina spp. (n = 4, Atyopsis moluccensis, Atya gabonensis, Arachnochium kulsiense and several taxa of exotic crabs (n = 5 belonging to three different genera (Cardiosoma, Geosesarma and Gecarinus present. Neocaridina davidi is identified as the most frequent in this regard. As some of the species can become established and form viable

  12. Beauty in abstract paintings: Perceptual contrast and statistical properties

    Directory of Open Access Journals (Sweden)

    Birgit eMallon

    2014-03-01

    Full Text Available In this study, we combined the behavioral and objective approach in the field of empirical aesthetics. First, we studied the perception of beauty by investigating shifts in evaluation on perceived beauty of abstract artworks (Experiment 1. Because the participants showed heterogeneous individual preferences for the paintings, we divided them into seven clusters for the test. The experiment revealed a clear pattern of perceptual contrast. The perceived beauty of abstract paintings increased after exposure to paintings that were rated as less beautiful, and it decreased after exposure to paintings that were rated as more beautiful. Next, we searched for correlations of beauty ratings and perceptual contrast with statistical properties of abstract artworks (Experiment 2. The participants showed significant preferences for certain image properties. These preferences differed between the clusters of participants. Strikingly, next to color measures like hue, saturation, value and lightness, the recently described PHOG self-similarity value seems to be a predictor for aesthetic appreciation of abstract artworks. We speculate that the shift in evaluation in Experiment 1 was, at least in part, based on low-level adaptation to some of the statistical image properties analyzed in Experiment 2. In conclusion, our findings demonstrate that the perception of beauty in abstract artworks is altered after exposure to beautiful or non-beautiful images and correlates with particular image properties, especially color measures and self-similarity.

  13. Beauty in abstract paintings: perceptual contrast and statistical properties

    Science.gov (United States)

    Mallon, Birgit; Redies, Christoph; Hayn-Leichsenring, Gregor U.

    2014-01-01

    In this study, we combined the behavioral and objective approach in the field of empirical aesthetics. First, we studied the perception of beauty by investigating shifts in evaluation on perceived beauty of abstract artworks (Experiment 1). Because the participants showed heterogeneous individual preferences for the paintings, we divided them into seven clusters for the test. The experiment revealed a clear pattern of perceptual contrast. The perceived beauty of abstract paintings increased after exposure to paintings that were rated as less beautiful, and it decreased after exposure to paintings that were rated as more beautiful. Next, we searched for correlations of beauty ratings and perceptual contrast with statistical properties of abstract artworks (Experiment 2). The participants showed significant preferences for particular image properties. These preferences differed between the clusters of participants. Strikingly, next to color measures like hue, saturation, value and lightness, the recently described Pyramid of Histograms of Orientation Gradients (PHOG) self-similarity value seems to be a predictor for aesthetic appreciation of abstract artworks. We speculate that the shift in evaluation in Experiment 1 was, at least in part, based on low-level adaptation to some of the statistical image properties analyzed in Experiment 2. In conclusion, our findings demonstrate that the perception of beauty in abstract artworks is altered after exposure to beautiful or non-beautiful images and correlates with particular image properties, especially color measures and self-similarity. PMID:24711791

  14. The True Bride: Perceptions of Beauty and Feminine Virtue in Folktales.

    Science.gov (United States)

    Trousdale, Ann

    1989-01-01

    Discusses the quality of the heroines' beauty in several folktales from various cultures. Notes that, unlike Western cultures that equate physical beauty with virtue, in many cultures, beauty is viewed as spiritual and emotional as well as physical. (MM)

  15. Could carnosine suppress zinc-mediated proteasome inhibition and neurodegeneration? Therapeutic potential of a non-toxic but non-patentable dipeptide.

    Science.gov (United States)

    Hipkiss, Alan R

    2005-01-01

    Ageing and neurodegenerative conditions are often associated with proteasome dysfunction, possibly mediated by zinc and/or copper ions. Studies have shown that (i) the olfactory lobe is normally enriched in carnosine and zinc, (ii) carnosine can suppress copper and zinc toxicity in olfactory neurones, (iii) olfactory dysfunction is often associated with neurodegenerative conditions and (iv) elevated levels of zinc are found in brains of Alzheimer's patients. It is suggested that nasal administration of carnosine should be explored as a possible way of suppressing zinc/copper-mediated proteasome inhibition and consequent neurodegeneration. PMID:16034682

  16. 抽脂美容酿纠纷依法调解显公正--医疗纠纷人民调解案例分析%Disputes Brewed by Liposuction Beauty, Fair Resolution through Mediation according to Law--People's Mediation Cases of Medical Disputes

    Institute of Scientific and Technical Information of China (English)

    雷红力

    2015-01-01

    医疗纠纷人民调解制度在全国各地逐渐展开,发挥了积极的作用。在调解过程中,需要运用到一系列的方法和技巧;就此,本文通过对一例抽脂美容手术的医疗纠纷的分析,详细讲述了根据现场实际情况巧妙使用一系列调解方法和技巧的过程,具有较好的实践借鉴和指引价值。%People's mediation system for medical disputes gradually spread all over the country, and it has played a positive role. We need apply a series of methods and techniques to the process of mediation. Therefore, taking one medical dispute of liposuction plastic surgery as an example, the author described in detail the media-tion process of ingenious use of a series of methods and techniques according to the actual situation, which had a good practical value for reference and guidance.

  17. Antibody-mediated phagocytosis contributes to the anti-tumor activity of the therapeutic antibody daratumumab in lymphoma and multiple myeloma

    DEFF Research Database (Denmark)

    Overdijk, M. B.; Verploegen, S.; Bogels, M.;

    2015-01-01

    Daratumumab (DARA) is a human CD38-specific IgG1 antibody that is in clinical development for the treatment of multiple myeloma (MM). The potential for IgG1 antibodies to induce macrophage-mediated phagocytosis, in combination with the known presence of macrophages in the tumor microenvironment i...

  18. Beautiful Architecture Leading Thinkers Reveal The Hidden Beauty In Software Design

    CERN Document Server

    Spinellis, Diomidis

    2009-01-01

    What are the ingredients of robust, elegant, flexible, and maintainable software architecture? Beautiful Architecture answers this question through a collection of intriguing essays from more than a dozen of today's leading software designers and architects. In each essay, contributors present a notable software architecture, and analyze what makes it innovative and ideal for its purpose.

  19. [Beauty judgment: review of the literature].

    Science.gov (United States)

    Faure, Jacques; Bolender, Yves

    2014-03-01

    Esthetic judgments are surely subjective, but as surely, that does not preclude them being studied objectively through rigorous scientific methods. The factual basis of a science of esthetics is not to settle whether some person or image is "objectively beautiful" but rather to determine whether some representative set or sets of individuals judge or experience him/her/it as beautiful or unattractive. The aim of this paper is to review the definitional, theoretical and methodological aspects pertaining to the perception of facial/dental attractiveness by a group of representative individuals. The first part lays down the basic principles of the perception of facial/dental attractiveness: the perception involves a jury, a field of investigation and a test providing quantitative data; the following general determinants of beauty perception are reviewed: the average morphology, the judge's cultural background, the numerology, the judge's ethnical origin. Indirect determinants are the dentition, the osseous architecture and the muscular envelope. Some disruptive factors might alter the judges' facial perception. They might be qualified as either peripheral to the face or psycho-social factors. Peripheral factors include hair style and color, skin hue, wrinkles, lips color... Psycho-social factors cover the personality of the subject being evaluated, his/her intelligence or behavior. The second part deals specifically with the methodology used to determine facial attractiveness and to correlate this latter with a specific morphology. Typically such a study aims to determine average esthetic preferences for some set of visual displays among a particular jury, given a specific task to judge esthetic quality or qualities. The sample being studied, the displays, the jury or jurys, the rating procedure must all be specified prior to collecting data. A specific emphasis will be given to the rating process and the associated morphometrics, the ultimate goal being to

  20. Beauty physics at e+ e- colliders

    International Nuclear Information System (INIS)

    Beauty physics to be performed in the next decade at the resonances Y(4S) and Z0 are compared. Large similarities are found in the physics program and the reconstruction techniques of Z0 and asymmetric Y(4S) colliders. The physics potential of the latter is found to be superior at equal luminosity to a symmetric machine, provided a large enough boost (≥ 5). Z0 machines will probably be the main source of the rich BS0 physics during that period

  1. Beautiful and other heavy baryons revisited

    Energy Technology Data Exchange (ETDEWEB)

    Martin, A.; Richard, J.M.

    1987-02-19

    We discuss the mass range for the beautiful baryons ..lambda../sub b/, ..sigma../sub b/ and ..sigma../sub b//sup */ allowed by rigorous inequalities which are derived in the framework of potential models but have probably a broader domain of validity. We obtain at the same time lower bounds on the masses of other baryons. We also compare the numerical prediction of several explicit models. There are convergent indications towards a mass of about 5.6 GeV for the ..lambda../sub b/.

  2. Safe is beautiful{exclamation_point}

    Energy Technology Data Exchange (ETDEWEB)

    Codee, H.D.K. [COVRA N.V., Vlissingen (Netherlands)]. E-mail: hccovra@zeelandnet.nl

    2006-07-01

    In the Netherlands long-term (100y) storage of all waste types in above ground, engineered structures, is a basic element of the waste management system. This is not a 'wait-and-see' solution, because at the same time provisions are taken for the final disposal. Facilities for treatment and storage of low, medium and high-level waste are in operation. The facility for high-level waste was commissioned in 2003. This facility is not only a technical building but also a work of art. We show that we are proud on our work. SAFE = BEAUTIFUL{exclamation_point} (author)

  3. A Beautiful Blonde: a Nash coordination game

    OpenAIRE

    Anderson, Simon P.; Maxim Engers

    2002-01-01

    In a memorable scene from the …lm ”A Beautiful Mind,” John Nash explains to his friends how to direct their attentions to women in a bar. Game theorists who have seen the …lm point out that the proposed solution is not a Nash equilibrium. Here we determine the Nash equilibria to the attention game. The symmetric mixed strategy equilibrium has resembles a common property resource problem. It has perverse comparative static properties that are not borne out by experimental data. Finally, we dis...

  4. Does it pay to be beautiful?

    OpenAIRE

    SIERMINSKA Eva

    2015-01-01

    It is a well-established view amongst economists that good-looking people have a better chance of employment and can earn more than those who are less physically attractive. A “beauty premium” is particularly apparent in jobs where there is a productivity gain associated with good looks, though this is different for women and men, and varies across countries. People also sort into occupations according to the relative returns to their physical characteristics; good-looking people take jobs wh...

  5. Haiti. Beauty parlours and health promoters.

    Science.gov (United States)

    Hughes, H

    1990-04-01

    In the poor neighborhoods of the capital city of Port au Prince Haiti are 100s of brightly painted beauty parlors, displaying signs like "Femme Moderne, studio de beaute." They are popular and cheap; between 70 and 80% of the population use them. In the south of the city, a team of health promotion volunteers are turning some 64 beauty parlors into AIDS education and condom distribution centers with the help and cooperation of the owners. The majority of these beauty parlors are owned and run by women who cannot find work elsewhere, including many immigrants from the Dominican Republic. Some proprietors work as prostitutes in the evenings because they cannot survive on the earnings of the parlors. These proprietors are now becoming AIDS educators-- talking to customers, handing out leaflets and distributing free condoms. The team of young volunteers responsible for this education program belong to the Center for Haitian Social Services (CHASS); a nonprofit, voluntary organization set up in 1987 as a community response to the lack of government health and social services. A CHASS volunteer explains: "The beauty parlors were chosen as a focal point for reaching the population. To start with, 1 box of condoms was distributed every week, not the owners are distributing 3 or 4 boxes. We encourage them to keep a record of numbers taken, client's age, sex, marital status and so on." The majority of volunteer health promoters are ex-students who have given up their studies because of lack of funds. Many cannot find jobs, and they are encouraged to develop skills in their volunteer work which could help them find employment in the future. The team of volunteers meets every Saturday to discuss the program and training needs that arise. "At first the focus of our training was on AIDS, but now we need more information about other related issues." The most urgent need is to find out what local people's thoughts and understandings are about the disease. CHASS has designed a

  6. The Aesthetics of Race versus the Beauty of Humanity.

    Science.gov (United States)

    Pontynen, Arthur

    2002-01-01

    Recommends rejecting race (an aesthetic concept) and returning to the apprehension, appreciation, and realization of beauty. Discusses aesthetics and racism, racism and postmodernism, and postmodernism and despair. Explains that recognition of the continuum from aesthetics to beauty would mark the demise of aesthetics and the rise of a new and…

  7. Transposons for cancer gene discovery: Sleeping Beauty and beyond

    OpenAIRE

    Collier, Lara S.; Largaespada, David A

    2007-01-01

    The use of Sleeping Beauty transposons as somatic mutagens to discover cancer genes in hematopoietic tumors and sarcomas has been documented. Here, we discuss the future of Sleeping Beauty for cancer genetic studies and the potential use of additional transposable elements for somatic mutagenesis.

  8. On the beauty of nature, paintings and music

    Directory of Open Access Journals (Sweden)

    Ekin Çoraklı

    2014-07-01

    Full Text Available There is a wide range of things that are classified by humans in terms of their level of beauty. The word ‘beautiful’ is used to define some of the natural entities living and nonliving, unnatural objects or ideas produced by humans, and the works of art, which are unique products of human hand and brain. Beauty, as a concept awakening a common feeling of pleasure, may mean something deeper than we are aware of. This meaning is perhaps hidden in its deeper aspects, which we have to give effort to analyze. Hence, within context of this paper, common and specific properties of the beauty of nature, paintings and music will be discussed. In addition, the stages of the perception of the beauty of all kinds will be called into question, and an account about the process of the judgment of beauty will be suggested. The specific types of beauty analyzed through the paper are limited with the beauty of nature, paintings and absolute music (music without words, following an opening remark about the beauty in general.

  9. Beauty: A Concept with Practical Implications for Teacher Researchers

    Science.gov (United States)

    Winston, Joe

    2011-01-01

    Hillman's (2001) simple affirmation that "an idea of beauty is useful, functional, practical" is one this article attempts to pursue with teacher researchers in mind, based on the belief that to move from the "re"pression of beauty to its "ex"pression--or, at the very least, to its articulation--will enlighten rather than distract individuals. The…

  10. Collider phenomenology of light strange-beauty squarks

    International Nuclear Information System (INIS)

    We summarize a study on the production, decay, and detection of the strange-beauty squark as light as 200 GeV at hadronic and e+e- colliders. It was motivated by nearly maximal mixing between strange and beauty squarks. (author)

  11. Charm and beauty measurements at Fermilab fixed target

    International Nuclear Information System (INIS)

    Eighteen months after a successful run of the Fermilab fixed target program, interesting results from several experiments are available. This is the first time that more than one Fermilab fixed target experiment has reported the observation of beauty mesons. In this paper the author reviews recent results from charm and beauty fixed target experiments at Fermilab

  12. Charm and beauty measurements at Fermilab fixed target

    International Nuclear Information System (INIS)

    Eighteen months after a successful run of the Fermilab fixed target program, interesting results from several experiments are available. This is the first time that more than one Fermilab fixed target experiment has reported the observation of beauty mesons. In this paper we review recent results from charm and beauty fixed target experiments at Fermilab

  13. Gender Differences in the Motivational Processing of Facial Beauty

    Science.gov (United States)

    Levy, Boaz; Ariely, Dan; Mazar, Nina; Chi, Won; Lukas, Scott; Elman, Igor

    2008-01-01

    Gender may be involved in the motivational processing of facial beauty. This study applied a behavioral probe, known to activate brain motivational regions, to healthy heterosexual subjects. Matched samples of men and women were administered two tasks: (a) key pressing to change the viewing time of average or beautiful female or male facial…

  14. Appreciating the Beauty of Science Ideas: Teaching for Aesthetic Understanding.

    Science.gov (United States)

    Girod, Mark; Rau, Cheryl

    A large body of literature exists in which scientists describe their field as beautiful and the work they do as inspired and passionate. Science teaching should strive to foster learning of substantive and powerful science ideas in ways that connect to the beauty inherent in those ideas. The conception of learning science in the study, that of…

  15. The experience of mathematical beauty and its neural correlates

    Directory of Open Access Journals (Sweden)

    Semir eZeki

    2014-02-01

    Full Text Available Many have written of the experience of mathematical beauty as being comparable to that derived from the greatest art. This makes it interesting to learn whether the experience of beauty derived from such a highly intellectual and abstract source such as mathematics correlates with activity in the same part of the emotional brain as that derived from more sensory, perceptually based, sources. To determine this, we used functional magnetic resonance imaging (fMRI to image the activity in the brains of 15 mathematicians when they viewed mathematical formulae which they had individually rated as beautiful, indifferent or ugly. Results showed that the experience of mathematical beauty correlates parametrically with activity in the same part of the emotional brain, namely field A1 of the medial orbito-frontal cortex (mOFC, as the experience of beauty derived from other sources.

  16. The experience of mathematical beauty and its neural correlates.

    Science.gov (United States)

    Zeki, Semir; Romaya, John Paul; Benincasa, Dionigi M T; Atiyah, Michael F

    2014-01-01

    Many have written of the experience of mathematical beauty as being comparable to that derived from the greatest art. This makes it interesting to learn whether the experience of beauty derived from such a highly intellectual and abstract source as mathematics correlates with activity in the same part of the emotional brain as that derived from more sensory, perceptually based, sources. To determine this, we used functional magnetic resonance imaging (fMRI) to image the activity in the brains of 15 mathematicians when they viewed mathematical formulae which they had individually rated as beautiful, indifferent or ugly. Results showed that the experience of mathematical beauty correlates parametrically with activity in the same part of the emotional brain, namely field A1 of the medial orbito-frontal cortex (mOFC), as the experience of beauty derived from other sources.

  17. Online Responses to a Multilingual Super Bowl Ad: Is "America the Beautiful" by Any Other Language Still America, the Beautiful?

    Science.gov (United States)

    Hoffman, Brooke Y.

    2016-01-01

    On 2 February 2014, an advertisement entitled "It's Beautiful" debuted during Super Bowl XLVIII, which was watched by 111.5 million people in the USA. The Coca-Cola advertisement portrayed people of various ethnicities and was accompanied by "America the Beautiful" sung in nine languages. Using critical discourse analysis, I…

  18. Charm and beauty structure of the proton

    CERN Document Server

    Brugnera, R

    2007-01-01

    This paper will review the data collected by the H1 and ZEUS Collaborations concerning the production of heavy quarks (charm and beauty) at the electron-proton collider HERA. Heavy quark production is an important testing ground for quantum chromodynamics (QCD), because QCD calculations are expected to be reliable if a hard scale is present in the process. In heavy quarks production a hard scale is provided by the quark mass. Moreover heavy quarks production can give direct access to the gluon density in the proton due to the fact that it proceeds, in QCD, almost exclusively via photon-gluon fusion, where a photon from the incoming electron interacts with a gluon in the proton giving an heavy quark-anti-quark pair. Results will be shown both for deep-inelastic scattering (DIS), where the virtuality of the exchanged boson Q**2 is large, and photo-production, where the Q**2 is equal to zero. Various experimental techniques are used in order to select charm and beauty events, ranging from the measurement of D* c...

  19. The beauty of the physical world

    CERN Multimedia

    CERN Bulletin

    2010-01-01

    Graham Farmelo, author and former particle physicist, visited CERN on 25 March. To the CERNois gathered in the Main Auditorium, he talked about his new book The Strangest Man, a biography of Paul Dirac. Dirac was obsessed by the importance of mathematical beauty in fundamental physics, a belief that was “almost a religion” to him. Farmelo himself has no doubts: among all of the natural phenomena the LHC may unveil, supersymmetry is the most beautiful.   Talking about the life of a physicist to draw the attention of the public to the science: that was the idea behind Graham Farmelo decision to write a biography of Paul Dirac. The book won the 2009 Costa Biography Award. “I chose Paul Dirac because he was the first truly modern theoretical physicist but he is virtually unknown to the public”, explains Graham Farmelo. “Dirac had a fascinating life. He was not born in a wealthy or a particularly brilliant family but he ended up conceiving in his head ...

  20. Structural Determinants of Sleeping Beauty Transposase Activity.

    Science.gov (United States)

    Abrusán, György; Yant, Stephen R; Szilágyi, András; Marsh, Joseph A; Mátés, Lajos; Izsvák, Zsuzsanna; Barabás, Orsolya; Ivics, Zoltán

    2016-08-01

    Transposases are important tools in genome engineering, and there is considerable interest in engineering more efficient ones. Here, we seek to understand the factors determining their activity using the Sleeping Beauty transposase. Recent work suggests that protein coevolutionary information can be used to classify groups of physically connected, coevolving residues into elements called "sectors", which have proven useful for understanding the folding, allosteric interactions, and enzymatic activity of proteins. Using extensive mutagenesis data, protein modeling and analysis of folding energies, we show that (i) The Sleeping Beauty transposase contains two sectors, which span across conserved domains, and are enriched in DNA-binding residues, indicating that the DNA binding and endonuclease functions of the transposase coevolve; (ii) Sector residues are highly sensitive to mutations, and most mutations of these residues strongly reduce transposition rate; (iii) Mutations with a strong effect on free energy of folding in the DDE domain of the transposase significantly reduce transposition rate. (iv) Mutations that influence DNA and protein-protein interactions generally reduce transposition rate, although most hyperactive mutants are also located on the protein surface, including residues with protein-protein interactions. This suggests that hyperactivity results from the modification of protein interactions, rather than the stabilization of protein fold.

  1. Structural Determinants of Sleeping Beauty Transposase Activity.

    Science.gov (United States)

    Abrusán, György; Yant, Stephen R; Szilágyi, András; Marsh, Joseph A; Mátés, Lajos; Izsvák, Zsuzsanna; Barabás, Orsolya; Ivics, Zoltán

    2016-08-01

    Transposases are important tools in genome engineering, and there is considerable interest in engineering more efficient ones. Here, we seek to understand the factors determining their activity using the Sleeping Beauty transposase. Recent work suggests that protein coevolutionary information can be used to classify groups of physically connected, coevolving residues into elements called "sectors", which have proven useful for understanding the folding, allosteric interactions, and enzymatic activity of proteins. Using extensive mutagenesis data, protein modeling and analysis of folding energies, we show that (i) The Sleeping Beauty transposase contains two sectors, which span across conserved domains, and are enriched in DNA-binding residues, indicating that the DNA binding and endonuclease functions of the transposase coevolve; (ii) Sector residues are highly sensitive to mutations, and most mutations of these residues strongly reduce transposition rate; (iii) Mutations with a strong effect on free energy of folding in the DDE domain of the transposase significantly reduce transposition rate. (iv) Mutations that influence DNA and protein-protein interactions generally reduce transposition rate, although most hyperactive mutants are also located on the protein surface, including residues with protein-protein interactions. This suggests that hyperactivity results from the modification of protein interactions, rather than the stabilization of protein fold. PMID:27401040

  2. The neural correlates of beauty comparison.

    Science.gov (United States)

    Kedia, Gayannée; Mussweiler, Thomas; Mullins, Paul; Linden, David E J

    2014-05-01

    Beauty is in the eye of the beholder. How attractive someone is perceived to be depends on the individual or cultural standards to which this person is compared. But although comparisons play a central role in the way people judge the appearance of others, the brain processes underlying attractiveness comparisons remain unknown. In the present experiment, we tested the hypothesis that attractiveness comparisons rely on the same cognitive and neural mechanisms as comparisons of simple nonsocial magnitudes such as size. We recorded brain activity with functional magnetic resonance imaging (fMRI) while participants compared the beauty or height of two women or two dogs. Our data support the hypothesis of a common process underlying these different types of comparisons. First, we demonstrate that the distance effect characteristic of nonsocial comparisons also holds for attractiveness comparisons. Behavioral results indicated, for all our comparisons, longer response times for near than far distances. Second, the neural correlates of these distance effects overlapped in a frontoparietal network known for its involvement in processing simple nonsocial quantities. These results provide evidence for overlapping processes in the comparison of physical attractiveness and nonsocial magnitudes. PMID:23508477

  3. The end of Sleeping Beauty's nightmare

    CERN Document Server

    Groisman, Berry

    2008-01-01

    The way a rational agent changes her belief in certain propositions/hypotheses in the light of new evidence lies at the heart of Bayesian inference. The basic natural assumption, as summarized in van Fraassen's Reflection Principle ([1984]), would be that in the absence of new evidence the belief should not change. Yet, there are examples that are claimed to violate this assumption. The apparent paradox presented by such examples, if not settled, would demonstrate the inconsistency and/or incompleteness of the Bayesian approach and without eliminating this inconsistency, the approach cannot be regarded as scientific. The Sleeping Beauty Problem is just such an example. The existing attempts to solve the problem fall into three categories. The first two share the view that new evidence is absent, but differ about the conclusion of whether Sleeping Beauty should change her belief or not, and why. The third category is characterized by the view that, after all, new evidence (although hidden from the initial view...

  4. The neural correlates of beauty comparison.

    Science.gov (United States)

    Kedia, Gayannée; Mussweiler, Thomas; Mullins, Paul; Linden, David E J

    2014-05-01

    Beauty is in the eye of the beholder. How attractive someone is perceived to be depends on the individual or cultural standards to which this person is compared. But although comparisons play a central role in the way people judge the appearance of others, the brain processes underlying attractiveness comparisons remain unknown. In the present experiment, we tested the hypothesis that attractiveness comparisons rely on the same cognitive and neural mechanisms as comparisons of simple nonsocial magnitudes such as size. We recorded brain activity with functional magnetic resonance imaging (fMRI) while participants compared the beauty or height of two women or two dogs. Our data support the hypothesis of a common process underlying these different types of comparisons. First, we demonstrate that the distance effect characteristic of nonsocial comparisons also holds for attractiveness comparisons. Behavioral results indicated, for all our comparisons, longer response times for near than far distances. Second, the neural correlates of these distance effects overlapped in a frontoparietal network known for its involvement in processing simple nonsocial quantities. These results provide evidence for overlapping processes in the comparison of physical attractiveness and nonsocial magnitudes.

  5. Assessing a peptidylic inhibitor-based therapeutic approach that simultaneously suppresses polyglutamine RNA- and protein-mediated toxicities in patient cells and Drosophila

    Directory of Open Access Journals (Sweden)

    Qian Zhang

    2016-03-01

    Full Text Available Polyglutamine (polyQ diseases represent a group of progressive neurodegenerative disorders that are caused by abnormal expansion of CAG triplet nucleotides in disease genes. Recent evidence indicates that not only mutant polyQ proteins, but also their corresponding mutant RNAs, contribute to the pathogenesis of polyQ diseases. Here, we describe the identification of a 13-amino-acid peptide, P3, which binds directly and preferentially to long-CAG RNA within the pathogenic range. When administered to cell and Drosophila disease models, as well as to patient-derived fibroblasts, P3 inhibited expanded-CAG-RNA-induced nucleolar stress and suppressed neurotoxicity. We further examined the combined therapeutic effect of P3 and polyQ-binding peptide 1 (QBP1, a well-characterized polyQ protein toxicity inhibitor, on neurodegeneration. When P3 and QBP1 were co-administered to disease models, both RNA and protein toxicities were effectively mitigated, resulting in a notable improvement of neurotoxicity suppression compared with the P3 and QBP1 single-treatment controls. Our findings indicate that targeting toxic RNAs and/or simultaneous targeting of toxic RNAs and their corresponding proteins could open up a new therapeutic strategy for treating polyQ degeneration.

  6. d-Amino Acid Substitution of Peptide-Mediated NF-κB Suppression in mdx Mice Preserves Therapeutic Benefit in Skeletal Muscle, but Causes Kidney Toxicity

    OpenAIRE

    Reay, Daniel P.; Bastacky, Sheldon I; Wack, Kathryn E; Stolz, Donna B.; Paul D Robbins; Clemens, Paula R

    2015-01-01

    In Duchenne muscular dystrophy (DMD) patients and the mdx mouse model of DMD, chronic activation of the classical nuclear factor-κB (NF-κB) pathway contributes to the pathogenesis that causes degeneration of muscle fibers, inflammation and fibrosis. Prior studies demonstrate that inhibition of inhibitor of κB kinase (IKK)-mediated NF-κB activation using l-isomer NF-κB essential modulator (NEMO)-binding domain (NBD) peptide-based approaches reduce muscle pathology in the mdx mouse. For our stu...

  7. Herpes simplex virus/Sleeping Beauty vector-based embryonic gene transfer using the HSB5 mutant: loss of apparent transposition hyperactivity in vivo.

    Science.gov (United States)

    de Silva, Suresh; Mastrangelo, Michael A; Lotta, Louis T; Burris, Clark A; Izsvák, Zsuzsanna; Ivics, Zoltán; Bowers, William J

    2010-11-01

    The Sleeping Beauty (SB) transposon system has been successfully used as a gene delivery tool in nonviral and viral vector platforms. Since its initial reconstruction, a series of hyperactive mutants of SB have been generated. Questions remain as to whether the enhanced in vitro activities of these SB transposase mutants translate to the in vivo setting, and whether such increased integration efficiencies will ultimately compromise the safety profile of the transposon platform by raising the risk of genomic insertional mutagenesis. Herein, we compared the in vivo impact of a herpes simplex virus (HSV) amplicon-vectored "wild-type" SB transposase (SB10) and a "hyperactive" SB mutant (HSB5), codelivered in utero with the HSVT-βgeo transposable reporter amplicon vector to embryonic day 14.5 C57BL/6 mice. The SB10 and HSB5 transposases do not disparately affect the viability and development of injected mouse embryos. Quantitation of brain-resident βgeo expression on postnatal day 21 revealed that mice receiving HSB5 exhibited only a trending increase in transgene expression compared with the SB10-infused group, an outcome that did not mirror the marked enhancement of HSB5-mediated transposition observed in vitro. These findings indicate that in vivo application of hyperactive SB mutants, although not differentially genotoxic to the developing mouse embryo, does not necessarily provide a significant therapeutic advantage over the employment of a lesser active SB when delivered in the context of the HSV/SB amplicon platform. PMID:20507234

  8. Dynamic Behavior of Microbubbles during Long Ultrasound Tone-Burst Excitation: Mechanistic Insights into Ultrasound-Microbubble Mediated Therapeutics Using High-Speed Imaging and Cavitation Detection.

    Science.gov (United States)

    Chen, Xucai; Wang, Jianjun; Pacella, John J; Villanueva, Flordeliza S

    2016-02-01

    Ultrasound (US)-microbubble (MB)-mediated therapies have been found to restore perfusion and enhance drug/gene delivery. On the presumption that MBs do not persist during long US exposure under high acoustic pressures, most schemes use short US pulses when a high US pressure is employed. However, we recently observed an enhanced thrombolytic effect using long US pulses at high acoustic pressures. Therefore, we explored the fate of MBs during long tone-burst exposures (5 ms) at various acoustic pressures and MB concentrations via direct high-speed optical observation and passive cavitation detection. MBs first underwent stable or inertial cavitation depending on the acoustic pressure and then formed gas-filled clusters that continued to oscillate, break up and form new clusters. Cavitation detection confirmed continued, albeit diminishing, acoustic activity throughout the 5-ms US excitation. These data suggest that persisting cavitation activity during long tone bursts may confer additional therapeutic effects. PMID:26603628

  9. Dynamic Behavior of Microbubbles during Long Ultrasound Tone-Burst Excitation: Mechanistic Insights into Ultrasound-Microbubble Mediated Therapeutics Using High-Speed Imaging and Cavitation Detection.

    Science.gov (United States)

    Chen, Xucai; Wang, Jianjun; Pacella, John J; Villanueva, Flordeliza S

    2016-02-01

    Ultrasound (US)-microbubble (MB)-mediated therapies have been found to restore perfusion and enhance drug/gene delivery. On the presumption that MBs do not persist during long US exposure under high acoustic pressures, most schemes use short US pulses when a high US pressure is employed. However, we recently observed an enhanced thrombolytic effect using long US pulses at high acoustic pressures. Therefore, we explored the fate of MBs during long tone-burst exposures (5 ms) at various acoustic pressures and MB concentrations via direct high-speed optical observation and passive cavitation detection. MBs first underwent stable or inertial cavitation depending on the acoustic pressure and then formed gas-filled clusters that continued to oscillate, break up and form new clusters. Cavitation detection confirmed continued, albeit diminishing, acoustic activity throughout the 5-ms US excitation. These data suggest that persisting cavitation activity during long tone bursts may confer additional therapeutic effects.

  10. A New Therapeutic Modality for Acute Myocardial Infarction: Nanoparticle-Mediated Delivery of Pitavastatin Induces Cardioprotection from Ischemia-Reperfusion Injury via Activation of PI3K/Akt Pathway and Anti-Inflammation in a Rat Model.

    Directory of Open Access Journals (Sweden)

    Kazuhiro Nagaoka

    Full Text Available There is an unmet need to develop an innovative cardioprotective modality for acute myocardial infarction (AMI, for which the effectiveness of interventional reperfusion therapy is hampered by myocardial ischemia-reperfusion (IR injury. Pretreatment with statins before ischemia is shown to reduce MI size in animals. However, no benefit was found in animals and patients with AMI when administered at the time of reperfusion, suggesting insufficient drug targeting into the IR myocardium. Here we tested the hypothesis that nanoparticle-mediated targeting of pitavastatin protects the heart from IR injury.In a rat IR model, poly(lactic acid/glycolic acid (PLGA nanoparticle incorporating FITC accumulated in the IR myocardium through enhanced vascular permeability, and in CD11b-positive leukocytes in the IR myocardium and peripheral blood after intravenous treatment. Intravenous treatment with PLGA nanoparticle containing pitavastatin (Pitavastatin-NP, 1 mg/kg at reperfusion reduced MI size after 24 hours and ameliorated left ventricular dysfunction 4-week after reperfusion; by contrast, pitavastatin alone (as high as 10 mg/kg showed no therapeutic effects. The therapeutic effects of Pitavastatin-NP were blunted by a PI3K inhibitor wortmannin, but not by a mitochondrial permeability transition pore inhibitor cyclosporine A. Pitavastatin-NP induced phosphorylation of Akt and GSK3β, and inhibited inflammation and cardiomyocyte apoptosis in the IR myocardium.Nanoparticle-mediated targeting of pitavastatin induced cardioprotection from IR injury by activation of PI3K/Akt pathway and inhibition of inflammation and cardiomyocyte death in this model. This strategy can be developed as an innovative cardioprotective modality that may advance currently unsatisfactory reperfusion therapy for AMI.

  11. A Translational Study of a New Therapeutic Approach for Acute Myocardial Infarction: Nanoparticle-Mediated Delivery of Pitavastatin into Reperfused Myocardium Reduces Ischemia-Reperfusion Injury in a Preclinical Porcine Model

    Science.gov (United States)

    Ichimura, Kenzo; Matoba, Tetsuya; Nakano, Kaku; Tokutome, Masaki; Honda, Katsuya; Koga, Jun-ichiro; Egashira, Kensuke

    2016-01-01

    Background There is an unmet need to develop an innovative cardioprotective modality for acute myocardial infarction, for which interventional reperfusion therapy is hampered by ischemia-reperfusion (IR) injury. We recently reported that bioabsorbable poly(lactic acid/glycolic acid) (PLGA) nanoparticle-mediated treatment with pitavastatin (pitavastatin-NP) exerts a cardioprotective effect in a rat IR injury model by activating the PI3K-Akt pathway and inhibiting inflammation. To obtain preclinical proof-of-concept evidence, in this study, we examined the effect of pitavastatin-NP on myocardial IR injury in conscious and anesthetized pig models. Methods and Results Eighty-four Bama mini-pigs were surgically implanted with a pneumatic cuff occluder at the left circumflex coronary artery (LCx) and telemetry transmitters to continuously monitor electrocardiogram as well as to monitor arterial blood pressure and heart rate. The LCx was occluded for 60 minutes, followed by 24 hours of reperfusion under conscious conditions. Intravenous administration of pitavastatin-NP containing ≥ 8 mg/body of pitavastatin 5 minutes before reperfusion significantly reduced infarct size; by contrast, pitavastatin alone (8 mg/body) showed no therapeutic effects. Pitavastatin-NP produced anti-apoptotic effects on cultured cardiomyocytes in vitro. Cardiac magnetic resonance imaging performed 4 weeks after IR injury revealed that pitavastatin-NP reduced the extent of left ventricle remodeling. Importantly, pitavastatin-NP exerted no significant effects on blood pressure, heart rate, or serum biochemistry. Exploratory examinations in anesthetized pigs showed pharmacokinetic analysis and the effects of pitavastatin-NP on no-reflow phenomenon. Conclusions NP-mediated delivery of pitavastatin to IR-injured myocardium exerts cardioprotective effects on IR injury without apparent adverse side effects in a preclinical conscious pig model. Thus, pitavastatin-NP represents a novel therapeutic

  12. Literary aesthetics: beauty, the brain, and Mrs. Dalloway.

    Science.gov (United States)

    Hogan, Patrick Colm

    2013-01-01

    Empirical research indicates that beauty is in part a matter of prototype approximation. Some research suggests that unanticipated pattern recognition is important as well. This essay begins by briefly outlining an account of beauty based on these factors. It goes on to consider complications. Minor complications include the partial incompatibility of these accounts and the importance of differentiating judgments of beauty from aesthetic response. More serious issues include the relative neglect of literature in neurologically-based discussions of beauty, which tend to focus on music or visual art. There is also a relative neglect of emotion, beyond the reward system. Finally, there is the almost complete absence of the sublime. After considering these problems broadly, the essay turns to Virginia Woolf's Mrs. Dalloway, examining its treatment of beauty and sublimity. The aim of this section is not merely to illuminate Woolf's novel by reference to neuroscientific research. It is equally, perhaps more fully, to expand our neuroscientifically grounded account of aesthetic response by drawing on Woolf's novel. In Mrs. Dalloway, there are gestures toward prototypes and patterns in beauty. But the key features are clearly emotional. Specifically, the emotions at issue in feelings of beauty and sublimity appear to be primarily attachment, on the one hand, and a profound sense of isolation, on the other. Woolf's novel also points us toward other features of aesthetic experience, crucially including the emotion-sharing that is a key function of the production and circulation of art.

  13. Literary aesthetics: beauty, the brain, and Mrs. Dalloway.

    Science.gov (United States)

    Hogan, Patrick Colm

    2013-01-01

    Empirical research indicates that beauty is in part a matter of prototype approximation. Some research suggests that unanticipated pattern recognition is important as well. This essay begins by briefly outlining an account of beauty based on these factors. It goes on to consider complications. Minor complications include the partial incompatibility of these accounts and the importance of differentiating judgments of beauty from aesthetic response. More serious issues include the relative neglect of literature in neurologically-based discussions of beauty, which tend to focus on music or visual art. There is also a relative neglect of emotion, beyond the reward system. Finally, there is the almost complete absence of the sublime. After considering these problems broadly, the essay turns to Virginia Woolf's Mrs. Dalloway, examining its treatment of beauty and sublimity. The aim of this section is not merely to illuminate Woolf's novel by reference to neuroscientific research. It is equally, perhaps more fully, to expand our neuroscientifically grounded account of aesthetic response by drawing on Woolf's novel. In Mrs. Dalloway, there are gestures toward prototypes and patterns in beauty. But the key features are clearly emotional. Specifically, the emotions at issue in feelings of beauty and sublimity appear to be primarily attachment, on the one hand, and a profound sense of isolation, on the other. Woolf's novel also points us toward other features of aesthetic experience, crucially including the emotion-sharing that is a key function of the production and circulation of art. PMID:24290272

  14. The Effects of Novelty and Familiarity on Beauty Perception

    Directory of Open Access Journals (Sweden)

    Hyejeong Jang

    2011-05-01

    Full Text Available In order to investigate how novelty and familiarity affect beauty perception, fractal images were presented five times over 14 weeks. Fractal images are unfamiliar to people, hence used in this study to control their previous experience. a total of 800 fractal images were divided into five groups (160 images X 5 group, and three groups of images were presented to participants each time for five times. The results showed that while beauty perception is decreased until the third exposure, it is increased from third to fifth exposure. These results suggest that a certain level of repeated exposure is necessary for subjects to become familiar, which in turn affect beauty perception.

  15. The Portraval of Beauty in Woman's Fashion Magazines

    OpenAIRE

    Moeran, Brian

    2009-01-01

    The primary contents of women’s fashion magazines are fashion, beauty and health. This paper sets out to explore the ways in which international fashion magazines such as Elle, Vogue and Marie Claire portray feminine beauty in textual and advertising matter and how their readers react to such portrayals. Beauty is analysed as grooming practice, and make-up as the prime symbol of the self and its many facets in social interaction. The paper looks at the different kinds of ‘fa...

  16. Why Beauty Still Cannot Be Measured

    Directory of Open Access Journals (Sweden)

    Ossi Naukkarinen

    2010-01-01

    Full Text Available This article focuses on the question of whether the latest results achieved in sciences such as evolution studies and brain research can help us understand the nature of aesthetic judgments. It suggests that such approaches may offer interesting insights for understanding many problems in aesthetics, but for clarifying aesthetic judgments one needs a philosophical point of view. Aesthetic judgments cannot be proven right or wrong by scientific methods, and beauty or other aesthetic qualities cannot be directly measured. The “method” of both making and analyzing aesthetic judgments is discussion, and the article clarifies why this is still the case, even if empirical, non-philosophical scientific methods are more accurate than ever before.

  17. Truth and beauty in contemporary urban photography

    Directory of Open Access Journals (Sweden)

    Daniele Colistra

    2014-05-01

    Full Text Available Does city still need photography? Or does it show itself more effectively through other forms of communication? The question brings us back almost two hundred years ago, at the time of the spread of the first daguerreotypes, when the query was: Does city still need painting? The question raises several other issues - truth and beauty, analogical and digital, truth and photo editing - that this essay examines by comparing some images. We are convinced that “the more we can speak of a picture, the more unlikely it is to speak of photography” (R. Barthes. The essay describes the work of some artists/photographers who have addressed the issue of urban photography. Works in which the figurative and visionary component is based on the interaction of traditional shooting techniques and processes of digital post-production.

  18. Defining and identifying Sleeping Beauties in science

    CERN Document Server

    Ke, Qing; Radicchi, Filippo; Flammini, Alessandro

    2015-01-01

    A Sleeping Beauty (SB) in science refers to a paper whose importance is not recognized for several years after publication. Its citation history exhibits a long hibernation period followed by a sudden spike of popularity. Previous studies suggest a relative scarcity of SBs. The reliability of this conclusion is, however, heavily dependent on identification methods based on arbitrary threshold parameters for sleeping time and number of citations, applied to small or monodisciplinary bibliographic datasets. Here we present a systematic, large-scale, and multidisciplinary analysis of the SB phenomenon in science. We introduce a parameter-free measure that quantifies the extent to which a specific paper can be considered an SB. We apply our method to 22 million scientific papers published in all disciplines of natural and social sciences over a time span longer than a century. Our results reveal that the SB phenomenon is not exceptional. There is a continuous spectrum of delayed recognition where both the hiberna...

  19. Rare FCNC top, beauty and charm decays

    CERN Document Server

    Blake, Thomas

    2014-01-01

    Rare flavour changing neutral current (FCNC) decays of top, beauty and charm quarks can provide a powerful probe for as yet unobserved particles. Recent results on FCNC $b \\to s$, $c \\to u$ and $t$ transitions from the LHC experiments are reviewed. Particular attention is paid to the angular distribution of the $B^{0} \\to K^{*0} \\mu^{+} \\mu^{-}$ decay, where a measurement performed by LHCb shows a local discrepancy of 3.7 standard deviations with respect to the SM prediction. Using the decay $B^{+} \\to K^{+}\\pi^{-}\\pi^{+}\\gamma$, LHCb have also been able to demonstrate the polarisation of photons produced in $b \\to s\\gamma$ transitions. More work is needed both experimentally and theoretically to understand if the Standard Model description of these rare FCNC processes is correct.

  20. Rare FCNC top, beauty and charm decays

    CERN Document Server

    Blake, T

    2014-01-01

    Rare flavour changing neutral current (FCNC) decays of top, beauty and charm quarks can provide a powerful probe for as yet unobserved particles. Recent results on FCNC $b \\to s$, $c \\to u$ and $t$ transitions from the LHC experiments are reviewed. Particular attention is paid to the angular distribution of the $B^{0} \\to K^{*0} \\mu^{+}\\mu^{-}$ decay, where a measurement performed by LHCb shows a local discrepancy of 3.7 standard deviations with respect to the SM prediction. Using the decay $B^{+} K^{+}\\pi^{-}\\pi^{+}\\gamma$, LHCb have also been able to demonstrate the polarisation of photons produced in $b \\to s \\gamma$ transitions. More work is needed both experimentally and theoretically to understand if the Standard Model description of these rare FCNC processes is correct.

  1. The 2012 interferometric imaging beauty contest

    Science.gov (United States)

    Baron, Fabien; Cotton, William D.; Lawson, Peter R.; Ridgway, Steve T.; Aarnio, Alicia; Monnier, John D.; Hofmann, Karl-Heinz; Schertl, Dieter; Weigelt, Gerd; Thiébaut, Eric; Soulez, Férréol; Mary, David; Millour, Florentin; Vannier, Martin; Young, John; Elias, Nicholas M.; Schmitt, Henrique R.; Rengaswamy, Sridharan

    2012-07-01

    We present the results of the fifth Interferometric Imaging Beauty Contest. The contest consists in blind imaging of test data sets derived from model sources and distributed in the OIFITS format. Two scenarios of imaging with CHARA/MIRC-6T were offered for reconstruction: imaging a T Tauri disc and imaging a spotted red supergiant. There were eight different teams competing this time: Monnier with the software package MACIM; Hofmann, Schertl and Weigelt with IRS; Thiebaut and Soulez with MiRA ; Young with BSMEM; Mary and Vannier with MIROIRS; Millour and Vannier with independent BSMEM and MiRA entries; Rengaswamy with an original method; and Elias with the radio-astronomy package CASA. The contest model images, the data delivered to the contestants and the rules are described as well as the results of the image reconstruction obtained by each method. These results are discussed as well as the strengths and limitations of each algorithm.

  2. The 2012 Interferometric Imaging Beauty Contest

    CERN Document Server

    Baron, Fabien; Lawson, Peter R; Ridgway, Steve T; Aarnio, Alicia; Monnier, John D; Hofmann, Karl-Heinz; Schertl, Dieter; Weigelt, Gerd; Thiébaut, Eric; Soulez, Férréol; Mary, David; Millour, Florentin; Vannier, Martin; Young, John; Elias, Nicholas M; Schmitt, Henrique R; Rengaswamy, Sridharan

    2012-01-01

    We present the results of the fifth Interferometric Imaging Beauty Contest. The contest consists in blind imaging of test data sets derived from model sources and distributed in the OIFITS format. Two scenarios of imaging with CHARA/MIRC-6T were offered for reconstruction: imaging a T Tauri disc and imaging a spotted red supergiant. There were eight different teams competing this time: Monnier with the software package MACIM; Hofmann, Schertl and Weigelt with IRS; Thi\\'ebaut and Soulez with MiRA ; Young with BSMEM; Mary and Vannier with MIROIRS; Millour and Vannier with independent BSMEM and MiRA entries; Rengaswamy with an original method; and Elias with the radio-astronomy package CASA. The contest model images, the data delivered to the contestants and the rules are described as well as the results of the image reconstruction obtained by each method. These results are discussed as well as the strengths and limitations of each algorithm.

  3. Fractal Beauty in Xinjiang Folk Art Patterns

    Institute of Scientific and Technical Information of China (English)

    PENG Hong; ZHAO Hai-ying

    2014-01-01

    Xinjiang folk art patterns and designs are the art treasures of Chinese cultural treasure-house as well as the precious humanistic resources of Western China. In the process of collecting, sorting out and studying Xinjiang folk art patterns, the elegant simplicity as well as the good taste stands out impressively, and the pattern shape as well as the layout composition shows a distinctive national trait and a strong local color. As “The Geometry of Nature”, fractal geometry brings about a new performing method. Various fractal graphs are created by different generators. Their dynamic pictures contain visual information of great magnitude and their artistic effect is similar to Xinjiang folk art patterns, which fully proves the fractal beauty in Xinjiang folk art patterns.

  4. EZH2-Mediated Inactivation of IFN-γ-JAK-STAT1 Signaling Is an Effective Therapeutic Target in MYC-Driven Prostate Cancer

    Directory of Open Access Journals (Sweden)

    Zhen Ning Wee

    2014-07-01

    Full Text Available Although small-molecule targeting of EZH2 appears to be effective in lymphomas carrying EZH2 activating mutations, finding similar approaches to target EZH2-overexpressing epithelial tumors remains challenging. In MYC-driven, but not PI3K-driven prostate cancer, we show that interferon-γ receptor 1 (IFNGR1 is directly repressed by EZH2 in a MYC-dependent manner and is downregulated in a subset of metastatic prostate cancers. EZH2 knockdown restored the expression of IFNGR1 and, when combined with IFN-γ treatment, led to strong activation of IFN-JAK-STAT1 tumor-suppressor signaling and robust apoptosis. Pharmacologic depletion of EZH2 by the histone-methylation inhibitor DZNep mimicked the effects of EZH2 knockdown on IFNGR1 induction and delivered a remarkable synergistic antitumor effect with IFN-γ. In contrast, although they efficiently depleted histone Lysine 27 trimethylation, EZH2 catalytic inhibitors failed to mimic EZH2 depletion. Thus, EZH2-inactivated IFN signaling may represent a therapeutic target, and patients with advanced prostate cancer driven by MYC may benefit from the combination of EZH2 and IFN-γ-targeted therapy.

  5. The role of tricyclic drugs in selective triggering of mitochondrially-mediated apoptosis in neoplastic glia. A therapeutic option in malignant glioma?

    International Nuclear Information System (INIS)

    We have previously demonstrated that the tricyclic antidepressant, Clomipramine, exerts a concentrationdependant, tumour cell specific, pro-apoptotic effect on human glioma cells in vitro and that this effect is not mirrored in non-neoplastic human astrocytes. Moreover, the drug acts by triggering mitochondrially-mediated apoptosis by way of complex 3 of the respiratory chain. Here, through reduced reactive oxygen species and neoplastic cell specific, altered membrane potential, cytochrome c is released, thereby activating a caspase pathway to apoptosis. In addition, while we and others have shown that further antidepressants, including those of the selective serotonin reuptake inhibitor (SSRI) group, also mediate cancer cell apoptosis in both glioma and lymphoma, clomipramine appears to be most effective in this context. More recently, other groups have reported that clomipramine causes apoptosis, preceded by a rapid increase in p-c-Jun levels, cytochrome c release from mitochondria and increased caspase-3-like activity. In addition to clomipramine we have investigated the possible pro-apoptotic activity of a range of further tricyclic drugs. Only two such agents (amitriptyline and doxepin) showed a similar, or better, effect when compared with clomipramine. Since both orally administered clomipramine and amitriptyline are metabolised to desmethyl clomipramine (norclomipramine) and nortriptyline respectively it is necessary for testing at a tumour cell level to be carried out with both the parent tricyclic and the metabolic product. In addition, reversal of multidrug resistance in a number of solid cancers following treatment with both clomipramine and amitriptyline has been reported. This additional role for tricyclics may be of some significance in the treatment of primary and secondary brain tumours. Since a substantial number of patients with malignant glioma have already received and are receiving clomipramine, both anecdotally and within a clinical trial, we

  6. Response rate of fibrosarcoma cells to cytotoxic drugs on the expression level correlates to the therapeutic response rate of fibrosarcomas and is mediated by regulation of apoptotic pathways

    International Nuclear Information System (INIS)

    Because of the high resistance rate of fibrosarcomas against cytotoxic agents clinical chemotherapy of these tumors is not established. A better understanding of the diverse modes of tumor cell death following cytotoxic therapies will provide a molecular basis for new chemotherapeutic strategies. In this study we elucidated the response of a fibrosarcoma cell line to clinically used cytostatic agents on the level of gene expression. HT1080 fibrosarcoma cells were exposed to the chemotherapeutic agents doxorubicin, actinomycin D or vincristine. Total RNA was isolated and the gene expression patterns were analyzed by microarray analysis. Expression levels for 46 selected candidate genes were validated by quantitative real-time PCR. The analysis of the microarray data resulted in 3.309 (actinomycin D), 1.019 (doxorubicin) and 134 (vincristine) probesets that showed significant expression changes. For the RNA synthesis blocker actinomycin D, 99.4% of all differentially expressed probesets were under-represented. In comparison, probesets down-regulated by doxorubicin comprised only 37.4% of all genes effected by this agent. Closer analysis of the differentially regulated genes revealed that doxorubicin induced cell death of HT1080 fibrosarcoma cells mainly by regulating the abundance of factors mediating the mitochondrial (intrinsic) apoptosis pathway. Furthermore doxorubicin influences other pathways and crosstalk to other pathways (including to the death receptor pathway) at multiple levels. We found increased levels of cytochrome c, APAF-1 and members of the STAT-family (STAT1, STAT3), while Bcl-2 expression was decreased. Caspase-1, -3, -6, -8, and -9 were increased indicating that these proteases are key factors in the execution of doxorubicin mediated apoptosis. This study demonstrates that chemotherapy regulates the expression of apoptosis-related factors in fibrosarcoma cells. The number and the specific pattern of the genes depend on the used cytotoxic drug

  7. Stromelysin-3 induction and interstitial collagenase repression by retinoic acid. Therapeutical implication of receptor-selective retinoids dissociating transactivation and AP-1-mediated transrepression.

    Science.gov (United States)

    Guérin, E; Ludwig, M G; Basset, P; Anglard, P

    1997-04-25

    Human stromelysin-3 and interstitial collagenase are matrix metalloproteinases whose expression by stromal cells in several types of carcinomas has been associated with cancer progression. We compared here the regulation of the expression of both proteinases by retinoids in human fibroblasts. Physiological concentrations of retinoic acid were found to simultaneously induce stromelysin-3 and repress interstitial collagenase. In both cases, the involvement of a transcriptional mechanism was supported by run-on assays. Furthermore, in transient transfection experiments, the activity of the stromelysin-3 promoter was induced by retinoic acid through endogenous receptors acting on a DR1 retinoic acid-responsive element. The ligand-dependent activation of the receptors was also investigated by using selective synthetic retinoids, and we demonstrated that retinoic acid-retinoid X receptor heterodimers were the most potent functional units controlling both stromelysin-3 induction and interstitial collagenase repression. However, specific retinoids dissociating the transactivation and the AP-1-mediated transrepression functions of the receptors were found to repress interstitial collagenase without inducing stromelysin-3. These findings indicate that such retinoids may represent efficient inhibitors of matrix metalloproteinase expression in the treatment of human carcinomas. PMID:9111003

  8. Sunflower Beauty Contest : tsvetõ zimoi / Marina Poltavtseva

    Index Scriptorium Estoniae

    Poltavtseva, Marina

    2001-01-01

    Lillekleitide võistlusest Sunflower Beauty Contest Tallinna klubis Decolte. Konkursi idee on florist Tatjana Tridvornovalt. Esimese koha sai Viimsi lilleäri lilleseadjate Meri-Liis Kõivu ja Triinu Põlderi lillekleit "Talvepruut"

  9. Isovector and hidden-beauty partners of the X(3872)

    Energy Technology Data Exchange (ETDEWEB)

    Høgaasen, Hallstein, E-mail: hallstein.hogasen@fys.uio.no [Department of Physics, University of Oslo, Box 1048, NO-0316 Oslo (Norway); Kou, Emi, E-mail: kou@lal.in2p3.fr [Laboratoire de l' Accélérateur Linéaire, Université Paris-Sud, IN2P3-CNRS, Centre Scientifique d' Orsay, 91898 Orsay Cedex (France); Richard, Jean-Marc, E-mail: j-m.richard@ipnl.in2p3.fr [Université de Lyon, Institut de Physique Nucléaire de Lyon, UCBL–IN2P3-CNRS, 4, rue Enrico Fermi, 69622 Villeurbanne Cedex (France); Sorba, Paul, E-mail: paul.sorba@lapth.cnrs.fr [LAPTh, Laboratoire d' Annecy-le-Vieux de Physique Théorique, CNRS, Université de Savoie, BP 110, 74941 Annecy-le-Vieux Cedex (France)

    2014-05-01

    The isovector partners of the X(3872), recently found at BES III, Belle and CLEO-c were predicted in a simple model based on the chromomagnetic interaction among quarks. The extension to the hidden-beauty sector is discussed.

  10. Trinity and beauty: The theological contribution of Jonathan Edwards

    Directory of Open Access Journals (Sweden)

    R. Venter

    2012-02-01

    Full Text Available The article explores the relationship between the trinitarian confession of God and beauty. Special attention is paid to Jonathan Edwards, the eighteenth-centur ypreacher and thinker, who in an exceptional manner viewed God in terms of beauty. The discussion is located in the context of a vigorous international Edwardsian scholarship on metaphysics, the nature of God and aesthetics. The article points out that beauty, according to Edwards, is primarily relational. The article aims at contributing to two neglected scholarly areas – the treatment of the doctrine of God in aesthetic terms, and the study of Jonathan Edwards in a South African context. Areas for further reflection are also identified. The article intimates that a discussion about trinity and beauty may have social ramifications.

  11. Measurement of beauty production from dimuon events at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Chekanov, S.; Derrick, M.; Magill, S. [Argonne National Laboratory, Argonne, IL (United States)] (and others)

    2008-09-15

    Beauty production in events containing two muons in the final state has been measured with the ZEUS detector at HERA using an integrated luminosity of 114 pb{sup -1}. A low transverse-momentum threshold for muon identification, in combination with the large rapidity coverage of the ZEUS muon system, gives access to almost the full phase space for beauty production. The total cross section for beauty production in ep collisions at {radical}(s) = 318 GeV has been measured to be {sigma}{sub tot}(ep {yields} b anti bX) = 13.9 {+-} 1.5(stat.){sub -4.3}{sup +4.0}(syst.) nb. Differential cross sections and a measurement of b anti b correlations are also obtained, and compared to other beauty cross-section measurements, Monte Carlo models and next-to-leading-order QCD predictions. (orig.)

  12. Measurement of beauty production in DIS and extraction at ZEUS

    Energy Technology Data Exchange (ETDEWEB)

    Abramowicz, H.; Ingbir, R.; Kananov, S.; Levy, A.; Stern, A. [Tel Aviv University, Raymond and Beverly Sackler Faculty of Exact Sciences, School of Physics, Tel Aviv (Israel); Abt, I.; Caldwell, A.; Kollar, D.; Reisert, B.; Schmidke, W.B. [Max-Planck-Institut fuer Physik, Muenchen (Germany); Adamczyk, L.; Bold, T.; Gach, G.; Grabowska-Bold, I.; Kisielewska, D.; Przybycien, M.; Suszycki, L. [AGH-University of Science and Technology, Faculty of Physics and Applied Computer Science, Cracow (Poland); Adamus, M.; Plucinski, P.; Tymieniecka, T. [Institute for Nuclear Studies, Warsaw (Poland); Aggarwal, R.; Kaur, M.; Kaur, P.; Singh, I. [Panjab University, Department of Physics, Chandigarh (India); Antonelli, S.; Basile, M.; Bindi, M.; Cifarelli, L.; Contin, A.; De Pasquale, S.; Sartorelli, G.; Zichichi, A. [University Bologna (Italy); INFN Bologna, Bologna (Italy); Antonioli, P.; Bari, G.; Bellagamba, L.; Boscherini, D.; Bruni, A.; Bruni, G.; Cindolo, F.; Corradi, M.; Iacobucci, G.; Margotti, A.; Nania, R.; Polini, A. [INFN Bologna, Bologna (Italy); Antonov, A.; Dolgoshein, B.A.; Gladkov, D.; Sosnovtsev, V.; Stifutkin, A.; Suchkov, S. [Moscow Engineering Physics Institute, Moscow (Russian Federation); Arneodo, M.; Ruspa, M. [Universita del Piemonte Orientale, Novara (Italy); INFN, Torino (Italy); Aushev, V.; Aushev, Y.; Borodin, M.; Gogota, O.; Kadenko, I.; Korol, I.; Kuprash, O.; Lontkovskyi, D.; Makarenko, I.; Onishchuk, Yu.; Salii, A.; Tomalak, O.; Viazlo, V.; Volynets, O.; Zenaiev, O.; Zhmak, N.; Zolko, M. [National Academy of Sciences, and Kiev National University, Institute for Nuclear Research, Kiev (Ukraine); Bachynska, O.; Behnke, O.; Behr, J.; Behrens, U.; Blohm, C.; Borras, K.; Bot, D.; Ciesielski, R.; Coppola, N.; Fang, S.; Geiser, A.; Goettlicher, P.; Grebenyuk, J.; Gregor, I.; Haas, T.; Hain, W.; Huettmann, A.; Januschek, F.; Kahle, B.; Katkov, I.I.; Klein, U.; Koetz, U.; Kowalski, H.; Libov, V.; Lisovyi, M.; Lobodzinska, E. [and others

    2010-10-15

    Beauty production in deep inelastic scattering with events in which a muon and a jet are observed in the final state has been measured with the ZEUS detector at HERA using an integrated luminosity of 114 pb{sup -1}. The fraction of events with beauty quarks in the data was determined using the distribution of the transverse momentum of the muon relative to the jet. The cross section for beauty production was measured in the kinematic range of photon virtuality, Q{sup 2}>2 GeV{sup 2}, and inelasticity, 0.05beauty contribution to the structure function F{sub 2} was extracted and is compared to theoretical predictions. (orig.)

  13. Collider phenomenology of light strange-beauty squarks

    International Nuclear Information System (INIS)

    Strong mixing between right-handed strange and beauty squarks is a possible solution to the CP violation discrepancy in B→φKS decay as recently suggested by the Belle data. In this scenario, thanks to the strong mixing one of the strange-beauty squarks can be as light as 200 GeV, even though the generic supersymmetry scale is at TeV. In this work, we study the production of this light right-handed strange-beauty squark at hadronic colliders and discuss the detection in various decay scenarios. Detection prospect at the Tevatron run II is good for the strange-beauty squark mass up to about 300 GeV

  14. Can we measure beauty? Computational evaluation of coral reef aesthetics

    NARCIS (Netherlands)

    A.F. Haas; M. Guibert; A. Foerschner; T. Co; S. Calhoun; E. George; M. Hatay; E. Dinsdale; S.A. Sandin; J.E. Smith; M.J.A. Vermeij; B. Felts; P. Dustan; P. Salamon; F. Rohwer

    2015-01-01

    The natural beauty of coral reefs attracts millions of tourists worldwide resulting in substantial revenues for the adjoining economies. Although their visual appearance is a pivotal factor attracting humans to coral reefs current monitoring protocols exclusively target biogeochemical parameters, ne

  15. Isovector and hidden-beauty partners of the X(3872)

    International Nuclear Information System (INIS)

    The isovector partners of the X(3872), recently found at BES III, Belle and CLEO-c were predicted in a simple model based on the chromomagnetic interaction among quarks. The extension to the hidden-beauty sector is discussed.

  16. Aesthetic experience of beautiful and ugly persons: a critique

    Directory of Open Access Journals (Sweden)

    Mika Suojanen

    2016-03-01

    Full Text Available The question of whether or not beauty exists in nature is a philosophical problem. In particular, there is the question of whether artworks, persons, or nature has aesthetic qualities. Most people say that they care about their own beauty. Moreover, they judge another person's appearance from an aesthetic point of view using aesthetic concepts. However, aesthetic judgements are not objective in the sense that the experience justifies their objectivity. By analysing Monroe C. Beardsley's theory of the objectivity of aesthetic qualities, I examine whether there are really beautiful and ugly persons in the world. I will criticize the way analytic philosophers judge people and art from an aesthetic perspective. If there are no aesthetic qualities in the world, nobody can judge someone beautiful or ugly without oppression. Aesthetic judgement is exercise of power.

  17. D-Amino Acid Substitution of Peptide-Mediated NF-κB Suppression in mdx Mice Preserves Therapeutic Benefit in Skeletal Muscle, but Causes Kidney Toxicity.

    Science.gov (United States)

    Reay, Daniel P; Bastacky, Sheldon I; Wack, Kathryn E; Stolz, Donna B; Robbins, Paul D; Clemens, Paula R

    2015-01-01

    In Duchenne muscular dystrophy (DMD) patients and the mdx mouse model of DMD, chronic activation of the classical nuclear factor-κB (NF-κB) pathway contributes to the pathogenesis that causes degeneration of muscle fibers, inflammation and fibrosis. Prior studies demonstrate that inhibition of inhibitor of κB kinase (IKK)-mediated NF-κB activation using L-isomer NF-κB essential modulator (NEMO)-binding domain (NBD) peptide-based approaches reduce muscle pathology in the mdx mouse. For our studies, the NBD peptide is synthesized as a fusion peptide with an eight-lysine (8K) protein transduction domain to facilitate intracellular delivery. We hypothesized that the d-isoform peptide could have a greater effect than the naturally occurring L-isoform peptide due to the longer persistence of the D-isoform peptide in vivo. In this study, we compared systemic treatment with low (1 mg/kg) and high (10 mg/kg) doses of L- and D-isomer 8K-wild-type-NBD peptide in mdx mice. Treatment with both L- or D-isoform 8K-wild-type-NBD peptide resulted in decreased activation of NF-κB and improved histology in skeletal muscle of the mdx mouse. However, we observed kidney toxicity (characterized by proteinuria), increased serum creatinine, activation of NF-κB and pathological changes in kidney cortex that were most severe with treatment with the D-isoform of 8K-wild-type-NBD peptide. The observed toxicity was also seen in normal mice. PMID:26018805

  18. Can We Model the Scenic Beauty of an Alpine Landscape?

    OpenAIRE

    Erich Tasser; Ulrike Tappeiner; Georg Leitinger; Maria Bacher; Sonja Hölzler; Uta Schirpke

    2013-01-01

    During the last decade, agriculture has lost its importance in many European mountain regions and tourism, which benefits from attractive landscapes, has become a major source of income. Changes in landscape patterns and elements might affect scenic beauty and therefore the socio-economic welfare of a region. Our study aimed at modeling scenic beauty by quantifying the influence of landscape elements and patterns in relationship to distance. Focusing on Alpine landscapes in South and North Ty...

  19. The experience of mathematical beauty and its neural correlates.

    OpenAIRE

    Semir eZeki; John Paul Romaya; Benincasa, Dionigi M. T.; Atiyah, Michael F.

    2014-01-01

    Many have written of the experience of mathematical beauty as being comparable to that derived from the greatest art. This makes it interesting to learn whether the experience of beauty derived from such a highly intellectual and abstract source such as mathematics correlates with activity in the same part of the emotional brain as that derived from more sensory, perceptually based, sources. To determine this, we used functional magnetic resonance imaging (fMRI) to image the activity in the b...

  20. Toward a brain-based theory of beauty.

    Science.gov (United States)

    Ishizu, Tomohiro; Zeki, Semir

    2011-01-01

    We wanted to learn whether activity in the same area(s) of the brain correlate with the experience of beauty derived from different sources. 21 subjects took part in a brain-scanning experiment using functional magnetic resonance imaging. Prior to the experiment, they viewed pictures of paintings and listened to musical excerpts, both of which they rated on a scale of 1-9, with 9 being the most beautiful. This allowed us to select three sets of stimuli--beautiful, indifferent and ugly--which subjects viewed and heard in the scanner, and rated at the end of each presentation. The results of a conjunction analysis of brain activity showed that, of the several areas that were active with each type of stimulus, only one cortical area, located in the medial orbito-frontal cortex (mOFC), was active during the experience of musical and visual beauty, with the activity produced by the experience of beauty derived from either source overlapping almost completely within it. The strength of activation in this part of the mOFC was proportional to the strength of the declared intensity of the experience of beauty. We conclude that, as far as activity in the brain is concerned, there is a faculty of beauty that is not dependent on the modality through which it is conveyed but which can be activated by at least two sources--musical and visual--and probably by other sources as well. This has led us to formulate a brain-based theory of beauty.

  1. DEVELOPMENT PROCESS OF BEAUTY AND HOLISM IN IRAN MOSQUE ARCHITECTURE

    OpenAIRE

    SHOJAEE, Farshid; PAEEZE, Mehran

    2015-01-01

    Abstract. The final goal of this article is to explain the accurate meaning of beauty ,finding general criteria of these concepts ,and mixing and their concrete appearance in Islamic architecture ,in particular mosques .Since finding a unique and basic definition for beauty in Islamic art and architecture requires vast research and existing definitions in Western and Islamic  philosophy  ,art, and architecture are significantly different , this research tries to explain these concepts clearly...

  2. Aesthetic experience of beautiful and ugly persons: a critique

    OpenAIRE

    Suojanen, Mika

    2016-01-01

    The question of whether or not beauty exists in nature is a philosophical problem. In particular, there is the question of whether artworks, persons, or nature has aesthetic qualities. Most people say that they care about their own beauty. Moreover, they judge another person’s appearance from an aesthetic point of view using aesthetic concepts. However, aesthetic judgements are not objective in the sense that the experience justifies their objectivity. By analysing Monroe C. Beardsley’s theor...

  3. pH-Responsive therapeutic solid lipid nanoparticles for reducing P-glycoprotein-mediated drug efflux of multidrug resistant cancer cells.

    Science.gov (United States)

    Chen, Hsin-Hung; Huang, Wen-Chia; Chiang, Wen-Hsuan; Liu, Te-I; Shen, Ming-Yin; Hsu, Yuan-Hung; Lin, Sung-Chyr; Chiu, Hsin-Cheng

    2015-01-01

    administration of DOX-loaded SLNs show that the SLNs have no observable side effects. These results indicate that the C-PEG-SLN is a promising platform for the delivery of therapeutic agents for MDR cancer chemotherapy.

  4. Reprogramming of Human Fibroblasts to Induced Pluripotent Stem Cells with Sleeping Beauty Transposon-Based Stable Gene Delivery.

    Science.gov (United States)

    Sebe, Attila; Ivics, Zoltán

    2016-01-01

    Human induced pluripotent stem (iPS) cells are a source of patient-specific pluripotent stem cells and resemble human embryonic stem (ES) cells in gene expression profiles, morphology, pluripotency, and in vitro differentiation potential. iPS cells are applied in disease modeling, drug screenings, toxicology screenings, and autologous cell therapy. In this protocol, we describe how to derive human iPS cells from fibroblasts by Sleeping Beauty (SB) transposon-mediated gene transfer of reprogramming factors. First, the components of the non-viral Sleeping Beauty transposon system, namely a transposon vector encoding reprogramming transcription factors and a helper plasmid expressing the SB transposase, are electroporated into human fibroblasts. The reprogramming cassette undergoes transposition from the transfected plasmids into the fibroblast genome, thereby resulting in stable delivery of the reprogramming factors. Reprogramming by using this protocol takes ~4 weeks, after which the iPS cells are isolated and clonally propagated.

  5. Reprogramming of Human Fibroblasts to Induced Pluripotent Stem Cells with Sleeping Beauty Transposon-Based Stable Gene Delivery.

    Science.gov (United States)

    Sebe, Attila; Ivics, Zoltán

    2016-01-01

    Human induced pluripotent stem (iPS) cells are a source of patient-specific pluripotent stem cells and resemble human embryonic stem (ES) cells in gene expression profiles, morphology, pluripotency, and in vitro differentiation potential. iPS cells are applied in disease modeling, drug screenings, toxicology screenings, and autologous cell therapy. In this protocol, we describe how to derive human iPS cells from fibroblasts by Sleeping Beauty (SB) transposon-mediated gene transfer of reprogramming factors. First, the components of the non-viral Sleeping Beauty transposon system, namely a transposon vector encoding reprogramming transcription factors and a helper plasmid expressing the SB transposase, are electroporated into human fibroblasts. The reprogramming cassette undergoes transposition from the transfected plasmids into the fibroblast genome, thereby resulting in stable delivery of the reprogramming factors. Reprogramming by using this protocol takes ~4 weeks, after which the iPS cells are isolated and clonally propagated. PMID:26895068

  6. A beautiful question finding nature’s deep design

    CERN Document Server

    Wilczek, Frank

    2015-01-01

    Artists as well as scientists throughout human history have pondered this “beautiful question.” With Nobel laureate Frank Wilczek as your guide, embark on a voyage of related discoveries, from Plato and Pythagoras up to the present. Wilczek’s groundbreaking work in quantum physics was inspired by his intuition to look for a deeper order of beauty in nature. In fact, every major advance in his career came from this intuition: to assume that the universe embodies beautiful forms, forms whose hallmarks are symmetry—harmony, balance, proportion—and economy. There are other meanings of “beauty,” but this is the deep logic of the universe—and it is no accident that it is also at the heart of what we find aesthetically pleasing and inspiring. Wilczek is hardly alone among great scientists in charting his course using beauty as his compass. As he reveals in A Beautiful Question, this has been the heart of scientific pursuit from Pythagoras, the ancient Greek who was the first to argue that “all thi...

  7. pH-Responsive therapeutic solid lipid nanoparticles for reducing P-glycoprotein-mediated drug efflux of multidrug resistant cancer cells

    Directory of Open Access Journals (Sweden)

    Chen HH

    2015-08-01

    enhanced passive tumor accumulation due to the loose intercellular junctions of endothelial cells lining inside blood vessels at tumor site, and the lack of lymphatic drainage. The growth of MCF-7/MDR xenografted tumor on Balb/c nude mice was inhibited to ~400 mm3 in volume as compared with the free DOX treatment group, 1,140 mm3, and the group treated with 1,2 distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol] solid lipid nanoparticles, 820 mm3. Analysis of the body weight of nude mice and the histology of organs and tumor after the administration of DOX-loaded SLNs show that the SLNs have no observable side effects. These results indicate that the C-PEG-SLN is a promising platform for the delivery of therapeutic agents for MDR cancer chemotherapy. Keywords: pH-responsive, solid lipid nanoparticles, multidrug resistance, permeability glycoprotein

  8. Mathematics make microbes beautiful, beneficial, and bountiful.

    Science.gov (United States)

    Jungck, John R

    2012-01-01

    Microbiology is a rich area for visualizing the importance of mathematics in terms of designing experiments, data mining, testing hypotheses, and visualizing relationships. Historically, Nobel Prizes have acknowledged the close interplay between mathematics and microbiology in such examples as the fluctuation test and mutation rates using Poisson statistics by Luria and Delbrück and the use of graph theory of polyhedra by Caspar and Klug. More and more contemporary microbiology journals feature mathematical models, computational algorithms and heuristics, and multidimensional visualizations. While revolutions in research have driven these initiatives, a commensurate effort needs to be made to incorporate much more mathematics into the professional preparation of microbiologists. In order not to be daunting to many educators, a Bloom-like "Taxonomy of Quantitative Reasoning" is shared with explicit examples of microbiological activities for engaging students in (a) counting, measuring, calculating using image analysis of bacterial colonies and viral infections on variegated leaves, measurement of fractal dimensions of beautiful colony morphologies, and counting vertices, edges, and faces on viral capsids and using graph theory to understand self assembly; (b) graphing, mapping, ordering by applying linear, exponential, and logistic growth models of public health and sanitation problems, revisiting Snow's epidemiological map of cholera with computational geometry, and using interval graphs to do complementation mapping, deletion mapping, food webs, and microarray heatmaps; (c) problem solving by doing gene mapping and experimental design, and applying Boolean algebra to gene regulation of operons; (d) analysis of the "Bacterial Bonanza" of microbial sequence and genomic data using bioinformatics and phylogenetics; (e) hypothesis testing-again with phylogenetic trees and use of Poisson statistics and the Luria-Delbrück fluctuation test; and (f) modeling of

  9. ISLAMIC BEAUTY: Socio-Semiotic Analysis of Facial Foam and Body Lotion Advertisement

    Directory of Open Access Journals (Sweden)

    Susi Herti Afriani

    2012-12-01

    Full Text Available This paper attempts to answer how Islamic Women define the concept of beauty in Ponds advertisement white beauty facial foam and body lotion on television. This study uses a socio-semiotic approach described through three aspects of social context, namely field, tenor, and mode. It argues that Ponds’ definition of a beauty only refers to physical standards, that is, women who have white skin and use both Ponds White Beauty Facial Foam and Foam Body Lotion. Further, television through Ponds advertising is considered as a commercial institution that supports the main idea of capitalism. However, Islamic women consider beautiful physically and spiritually. It suggests that the beautiful women are those who obey and surrender to Allah SWT. In short, Islamic women do not agree with the meaning of beauty resulted from Ponds White Beauty Facial Foam and Ponds Body Lotion advertisement. Rather, beauty consists of both body and, more importantly, soul.

  10. Academic Training: Small may be beautiful

    CERN Multimedia

    Françoise Benz

    2005-01-01

    2004-2005 ACADEMIC TRAINING PROGRAMME LECTURE SERIES 13, 14, 15, 16 and 17 June 13, 14, 16, 17 June from 11:00 to 12:00, 15 June from 10:00 to 12:00 - Auditorium, bldg. 500 Small may be beautiful M. DAVIER / LAL, Orsay, France and T. SOLDNER / ILL, Grenoble, France M. DAVIER 13, 14, 15 June Besides the direct high-energy approach, particle physics frontiers can be explored by low-energy high-sensitivity experiments. These experiments, small on the scale of LHC detectors, can be very effective in reaching a sensitivity level why physics beyond the Standard Model can contribute. In these lectures we will discuss a subject of such experiments (excluding cold neutrons covered in T. Soldner's lectures), their interplay with theory and their impact on our knowledge of new phenomena : anormalous magnetic moments of leptons, weak-electromagnetic interference at low energy and in atomic physics, searches for an electron electric dipole moment in atomic and molecular physics. T. SOLDNER 15, 16, 17 June Neutron pa...

  11. Sleeping Beauty: Kleine–Levin Syndrome

    Science.gov (United States)

    Mudgal, Soumiya; Jiloha, R. C.; Kandpal, Manish; Das, Aparna

    2014-01-01

    Kleine–Levin syndrome (KLS) alias sleeping beauty syndrome, is a rare sleep disorder. Clinically presenting as episodes of hypersomnolence, behavioral and cognitive disturbances, hyperphagia and hypersexuality. KLS may have an idiopathic onset or may be precipitated by neurological event or infection. Until date, no definite underlying cause is established and neither there are any definitive management guidelines. It remains a diagnosis of exclusion after other psychiatric and neurological causes have been ruled out. Coloring of presentation with behavioral and mood elements makes it important for a psychiatrist to be well-informed about the condition to avoid the erroneous diagnosis. KLS is a devastating illness, which robs the patient of time, experiences, and relationships. An early diagnosis and effective management can help patient escape from the morbidity caused by this disorder. Armodafinil and oxcarbamazepine have found to be effective in two of the case. The emphasis of this report is to add to the existing clinical knowledge of neurologists, psychiatrists and physicians. In the future, research is needed on genetic etiology and management of this disorder. PMID:25316944

  12. Unification: Not Just a Thing of Beauty

    Directory of Open Access Journals (Sweden)

    Ioannis Votsis

    2015-03-01

    Full Text Available We often hear that simplicity, explanatory power and unification, though aesthetically pleasing or beautiful qualities, are at best pragmatic considerations in matters of choosing between rival hypotheses. This paper aims to offer a novel conception and an associated measure of unification, both of which are demonstrably more than just pragmatic considerations. The discussion departs from a brief survey of some failed attempts to carve out adequate conceptions of unification. It then proceeds to an analysis of the notions of confirmational connectedness and disconnectedness. Roughly speaking, these notions attempt to capture the way support propagates or fails to propagate between the content parts of a hypothesis or, equivalently, between the contents of two or more hypotheses. The two notions are instrumental in helping to tackle the problem of ad hoc, and in particular monstrous, hypotheses. More importantly for the purposes of this paper, they are essential ingredients in the proposed conception of unification and its associated measure. In simple terms, the more the content of a hypothesis (or, equivalently, the content of a set of hypotheses is confirmationally connected the more that content is unified. Since the confirmational connectedness of two content parts is determined by purely objective matters of fact, the proposed notion and measure of unification are themselves strictly objective, i.e. not merely pragmatic considerations in matters of hypothesis choice. The paper concludes with a discussion of how the proposed measure handles real and hypothetical examples but also how it stands up to various objections.

  13. Beauty physics in lattice gauge theory

    International Nuclear Information System (INIS)

    We summarize the present status of lattice gauge theory computations of the leptonic decay constants fD and fB. The various sources of systematic errors are explained in a manner easily understood by the non-expert. The results obtained by the different groups are then systematically compared. As a result, we derive estimates for fD and fB in the quenched approximation through an appropriate combination of the data available from the different groups. Since we account for a possible lattice spacing dependence, the final errors are quite large. However, it is now well known how these uncertainties can be reduced. For the decay constant of heavy-light pseudoscalar mesons with masses of 1-2 GeV, an interesting comparison of a full QCD result with the corresponding simulation in the quenched approximation can be done. Effects of sea quarks of mass ms are below the statistical accuracy of these simulations. Related quantities, like B-parameters, the spectrum of beauty-hadrons and the breaking of the QCD string are discussed briefly. (orig.)

  14. Charm and beauty production at LHC

    CERN Document Server

    Carrer, N

    2003-01-01

    We define here the present ALICE baseline for what concerns the heavy flavour production cross sections at LHC and the kinematical distributions of the heavy quark pairs. We start by qualitatively assessing the Bjorken x regimes accessible with charm and beauty measurements at LHC with ALICE (Section 1). In Section 2 we report the most recent results (and the uncertainties) of the next-to-leading order (NLO) pQCD calculations for the cross sections in pp collisions at LHC energies. These results are extrapolated to Pb-Pb collisions in Section 3.1 and to p-Pb collisions in Section 3.2, taking into account nuclear shadowing and parton intrinsic transverse momentum broadening. Heavy quark kinematics as given by the NLO pQCD calculation are reported in Section 4. We tuned the PYTHIA event generator in order to reproduce such results for what concerns the c and b quarks transverse momentum distributions (Section 5). Finally, we report the yields and transverse momentum distributions for D and B mesons (section 6).

  15. Beautiful mesons from QCD spectral sum rules

    Energy Technology Data Exchange (ETDEWEB)

    Narison, S.

    1988-08-18

    We apply q/sup 2/ = 0 moments within n (number of derivatives) and t/sub c/ (continuum threshold) stability criteria to the beautiful-meson systems. The optimal predictions are reached for the same ranges of n and t/sub c/ values leading to the previous estimate of the decay constant f/sub B/. The QCD scales (b-quark 'physical' mass, mixed and four-quark condensates) are strongly constrained by the observed B and B/sup */ masses. The predictions for the S- and P-state splittings are much affected by the definition of the b-quark mass (pole or euclidian) entering into the Wilson coefficients of the non-perturbative condensates. The size of the SU(3)/sub F/ breaking on the mass splittings cannot be accurately predicted due to the imprecise value of the / condensate ratio. We present new predictions for the B/sub c/ and B/sub c//sup */ mesons.

  16. Artists with Arthritis Create Beauty amid Pain

    Institute of Scientific and Technical Information of China (English)

    Alan; Mozes; 蔡峥伟

    2000-01-01

    得此来稿,我们曾犹豫再三,是否刊用此文。因为,其内容给人的第一印象颇有点离奇。Artists with Arthritis Create Beauty amid Pain,怎么可能呢?细读之下,你也许会觉得,此文虽是一家之言,但也并非荒唐。尤其是本文的收尾句,笔锋一转,抖出了妙言: ...in addition to the emotional support such stories can give RA patients,there are now new drug options that far surpass the treatment choices Renoir faced. 此句是否可译:除了此类故事能够给患风湿病者一种情感上的支持之外,现在可选的新药要比Renoir(雷诺阿,法国印象派画家。主要作品有《包厢》、《游船上的午餐》、《浴女》等。)时代强得多。

  17. Charm and Beauty Production from Secondary Vertexing at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Thompson, Paul [University of Birmingham, Edgbaston, Birmingham, B15 2TT (United Kingdom)

    2010-07-01

    Measurement of the Charm and Beauty Structure Functions using the H1 Vertex Detector at HERA Inclusive charm and beauty cross sections are measured in e{sup -} p and e{sup +}p neutral current collisions at HERA in the kinematic region of photon virtuality 5 < Q{sup 2} < 2000 GeV{sup 2} and Bjorken scaling variable 0.0002 < x < 0.05. The data were collected with the H1 detector in the years 2006 and 2007 corresponding to an integrated luminosity of 189 pb{sup -1}. The numbers of charm and beauty events are determined using variables reconstructed by the H1 vertex detector including the impact parameter of tracks to the primary vertex and the position of the secondary vertex. The measurements are combined with previous data and compared to QCD predictions. Measurement of Charm and Beauty Jets in Deep Inelastic Scattering at HERA Measurements of the charm and beauty jet cross sections have been made in deep inelastic scattering at HERA for the kinematic region of photon virtuality Q{sup 2} > 6 GeV{sup 2} and elasticity variable 0.07 < y < 0.625 for jets in the laboratory frame with transverse energy E{sub T}{sup jet} > 6 GeV and pseudorapidity -1.0 < {eta}{sup jet} < 1.5. Measurements are also made requiring a jet in the Breit frame with E{sub T}{sup jet} > 6 GeV. The data were collected with the H1 detector in the years 2006 and 2007 corresponding to an integrated luminosity of 189 pb{sup -1}. The number of charm and beauty jets are determined using variables reconstructed by the H1 vertex detector including the impact parameter of tracks to the primary vertex and the position of the secondary vertex. The measurements are compared with QCD predictions and with previous measurements obtained using muon tagging. Charm and beauty production in deep inelastic scattering from inclusive secondary vertexing at ZEUS Charm and beauty production in deep inelastic scattering has been measured with the ZEUS detector using the full HERA II data set. The charm and beauty contents

  18. Therapeutic alliance.

    Science.gov (United States)

    Fox, Valerie

    2002-01-01

    I have been very fortunate in my journey of mental illness. I respond well to medication, but I don't think that is the complete answer to living successfully with serious, persistent mental illness. I believe a person's environment is also of utmost importance, enabling the person suffering with mental illness to continually grow in life. I found early in my struggle with mental illness a psychiatrist with whom I have always had a very good rapport. Until recently I didn't know that what I have with this psychiatrist is professionally known as a therapeutic alliance. Over the years, when I need someone to talk over anything that is troubling to me, I seek my psychiatrist. A therapeutic alliance is non-judgmental; it is nourishing; and finally it is a relationship of complete trust. Perhaps persons reading this article who have never experienced this alliance will seek it. I believe it can make an insecure person secure; a frightened person less frightened; and allow a person to continue the journey of mental health with a sense of belief in oneself. PMID:12433224

  19. Models as Mediators

    DEFF Research Database (Denmark)

    Sommerlund, Julie

    from laboratory studies, (Latour 1979; Lynch 1985; Sommerlund 2004 (2007); Sommerlund 2006) and is complemented by the attention paid to the "mediator" by Hennion (1989; 1997; 2005). The empirical focus will be on a central - but overlooked - actor of branding and advertising; the model. The model has...... solely been theorized within cultural studies (Craik 1994) as feminine spectacle, but has been neglected as mediator and actor. This paper will argue that models are co-producers of brands, and vice versa. Empirically, the paper will present interviews with models, model-scouts, agents, and advertisers....... Jacobs, Nancy Weiss. Oxford, Blackwell Publishing. Latour, B. W., Steve (1979). Laboratory Life. London, New Delhi, Sage. Lynch, M. (1985). Art and artifact in laboratory science. London, Boston, Melbourne and Henley, Routledge & Kegan Paul. Sommerlund, J. (2004 (2007)). "Beauty and Bacteria...

  20. Can We Model the Scenic Beauty of an Alpine Landscape?

    Directory of Open Access Journals (Sweden)

    Erich Tasser

    2013-03-01

    Full Text Available During the last decade, agriculture has lost its importance in many European mountain regions and tourism, which benefits from attractive landscapes, has become a major source of income. Changes in landscape patterns and elements might affect scenic beauty and therefore the socio-economic welfare of a region. Our study aimed at modeling scenic beauty by quantifying the influence of landscape elements and patterns in relationship to distance. Focusing on Alpine landscapes in South and North Tyrol, we used a photographic questionnaire showing different landscape compositions. As mountain landscapes offer long vistas, we related scenic beauty to different distance zones. Our results indicate that the near zone contributes by 64% to the valuation of scenic beauty, the middle zone by 22%, and the far zone by 14%. In contrast to artificial elements, naturalness and diversity increased scenic beauty. Significant differences between different social groups (origin, age, gender, cultural background occurred only between the local population and tourists regarding great landscape changes. Changes towards more homogenous landscapes were perceived negatively, thus political decision makers should support the conservation of the cultural landscape.

  1. Introducing a "Balance" in The BSC Through Beauty and Love

    Directory of Open Access Journals (Sweden)

    Ari Kamayanti

    2010-04-01

    Full Text Available Celebrating the seventeenth anniversary of the Balanced Score Card (BSC since it was born in 1992, this paper revisits its concept as one of the landmarks in performance measurement. The BSC turns out to be ‘not so balanced’ since it lacks certain beauty and love. It hinges on accountability for certain interests when measuring performance, negating or putting other interests as minority. Thus, it fits perfectly with the aim of management accounting that puts managers and customers as priorities. The imbalances comes from secularism and overemphasis in rationalism. Sustainability that becomes the current issue nowadays would not be supported by such performance measurement. In order to insert this balance, a methodology by taking a methapor of nurturing mother is applied in this research that encompasses gentle beauty and subtle love. Gentle beauty refers to a complete harmony of beauty : irrational and the rational; this means introducing those that have been left out in the name of rationality such as religions and spiritualism. Subtle love refers to love towards God that is expressed subtly without lust to overpower. The result is a more balanced set of performance measurements that are filled with beauty and love, insyaAllah.

  2. Beauty photoproduction using decays into muons at HERA

    International Nuclear Information System (INIS)

    Inclusive cross-sections for the production of open beauty in ep collisions at HERA are measured. The data were recorded with the ZEUS detector between 1996 and 2000. The measurements are restricted to photoproduction processes, i.e. collision events with small four-momentum transfer squared, Q2∼0. Two jets with transverse momentum pT>7(6) GeV and pseudo-rapidities vertical stroke η vertical stroke <2.5 are required. The flavour is tagged by the identification of muons from semi-leptonic decays of the beauty quark. The variable used to discriminate between beauty and background is the transverse momentum of the muon with respect to the jet axis. The fraction of beauty is determined by a fit of Monte Carlo templates to the data. Cross-sections have been measured as a function of the muon and jet variables as well as a function of dijet correlation variables. Dijet correlations in beauty production have been measured for the first time in ZEUS and are found in agreement with QCD NLO predictions. (orig.)

  3. ARGUS results on beauty and charm

    International Nuclear Information System (INIS)

    Using the ARGUS detector at the e+e- storage ring DORIS II at DESY new results on beauty and charm physics have been obtained. With more data an update on B0B-bar0 mixing is given for the mixing parameter r = (21±6) %. The investigation of the decay B-bar0 → D*+l-ν allows a determination of the Kobayashi-Maskawa element |Vcb| = 0.052±0.011. The lifetime ratio of charged and neutral B mesons is measured to be τB+/τB0 = 1.00±0.23±0.14. In semileptonic B decays, as well as in exclusive B decays, no significant signals are found for b→u or b→s transitions. In charm physics, the spin of the D*(2459) is shown to be J=2. The enhancement, previously known as the D*(2420), seen in the final state D*(2010)+π-, is resolved into two relatively narrow resonances separated in mass by approximately 40 MeV/c2. The results of a decay angular analysis are in good agreement with the interpretation of the two states as L=1 D mesons of spin-parities 1+ and 2+. The charged isospin partner of the D*(2459)0 is observed at a mass of (2469±4±6) MeV/c2, decaying to D0π+. The isospin mass splitting is measured to be (14±5±8) MeV/c2. Finally, the first excited P-wave Ds meson has been observed in the decay D*s(2536) → D*+Ks0. (author)

  4. Charm and beauty production from Fermilab experiment 789

    Energy Technology Data Exchange (ETDEWEB)

    Brown, C.N.; Cooper, W.E.; Glass, H.D.; Gounder, K.N.; Mishra, C.S. [Fermi National Accelerator Lab., Batavia, IL (United States); Boissevain, J.; Carey, T.A.; Jansen, D.M.; Jeppesen, R.G.; Kapustinsky, J.S. [Los Alamos National Lab., NM (United States)] [and others

    1994-12-31

    Fermilab E789 is a fixed-target charm and beauty experiment which uses a 2-arm spectrometer outfitted with a silicon vertex detector to look for 2-body decays of charm and beauty. The differential cross section for production and the nuclear dependence of neutral D meson production, and the D{sup 0}/D{sup 0}-bar production asymmetry has been measured. Evidence has been seen for beauty production via the inclusive decay B {yields} J/{psi}X, by observing J/{psi} decays well downstream of the target, and have measured a differential cross section for J/{psi} from b or b-bar for 800 GeV pN collisions. (author). 4 refs., 4 figs.

  5. The Offence of Beauty in Modern Western Art Music

    Directory of Open Access Journals (Sweden)

    Peter Bannister

    2013-12-01

    Full Text Available In recent decades, beauty has become a largely unfashionable, even offensive notion within art and philosophy. As Eastern Orthodox theologian, David Bentley Hart, has pointed out, this offence has a twofold sense. Firstly, the ‘beautiful’ has been dismissed as philosophically insignificant in comparison to the ‘sublime’ by an intellectual tradition tracing itself back to Immanuel Kant’s Critique of Judgment. Secondly, the making of apparently beautiful art has, especially after the Shoah, frequently been regarded as ethically offensive in the face of suffering in the world. The present essay discusses how these two critiques of the beautiful find themselves reflected in twentieth and twenty-first century musical aesthetics, with particular reference to the writings of Theodor W. Adorno, and asks what solutions have been found by composers of Christian sacred music in the Western tradition confronted by this ‘taboo on beauty’.

  6. The Super Fixed Target beauty facility at the SSC

    International Nuclear Information System (INIS)

    The rationale for pursuing beauty physics at the SSC in a fixed target configuration is described. The increased beauty production cross section at the SSC, combined with high interaction rate capability of the proposed detector, results in 1010-11 produced BB events per year. The long decay length of the B hadrons (≅ 10 cm) allows direct observation of B decays in the high resolution silicon microstrip vertex detector. To optimize the operation of the proposed beauty spectrometer and the SSC, parasitic extraction of attendant or artificially generated large amplitude protons using crystal channeling is proposed and explored. The large sample of fully reconstructed B events allows detailed studies of various CP violating decays with requisite statistics to confront the standard model. The CP physics potential of the proposed experiment is evaluated and compared with alternative approaches, such as symmetric e+e- B Factories and specialized hadron colliders

  7. The beautiful infant and Israel’s salvation

    Directory of Open Access Journals (Sweden)

    James A. Loader

    2011-06-01

    Full Text Available The motif from the Exodus story of Moses as a beautiful infant is considered on several levels. Firstly, the immediate context of Exodus 2 in the Hebrew Bible and in the Septuagint is investigated. Exodus 2 is then related to the reception of the tradition in the New Testament and Jewish sources as well as in a patristic reading and one from the Reformation. The article concludes that the motif of Moses’ beauty is part of a relatively infrequent but nevertheless well-established constellation. It is submitted that this finding contributes to a reappraisal of the idea that the motif of beauty has no place in Israel’s texts of deliverance and an investigation of the contrary hypothesis is called for.

  8. Is it Really Skin Deep? An Analysis of "Ugly Betty's" Influence on Females' Understanding of Beauty

    OpenAIRE

    Goldman, Adria Yvonne

    2009-01-01

    The current study explores the influence nontraditional framing of beauty and ugliness has on college aged femalesâ interpretation of beauty. Focus group sessions were used to assess this influence, during which the women were asked several questions within two open discussions of beauty. The television sitcom Ugly Betty, which features an alternative framing of beauty standards, was shown between each discussion and used to analyze the mediaâ s influence. The results show that the discuss...

  9. E789 and P865: High-rate fixed-target studies of charm and beauty

    International Nuclear Information System (INIS)

    Experiment 789 at Fermilab used the high-rate E605/E772 spectrometer to study low-multiplicity charm and beauty decays. Preliminary results on charm and beauty production are presented based on analysis of ∼ 100% of the charm data and ∼ 50% of the beauty data. A new experiment is proposed to improve charm and beauty sensitivity by several orders of magnitude

  10. Beauty in photoproduction at HERA II with the ZEUS detector

    Energy Technology Data Exchange (ETDEWEB)

    Boutle, Sarah

    2010-02-15

    The production of beauty quarks in ep collisions should be accurately calculable in perturbative Quantum Chromodynamics (QCD) since the large mass of the b quark provides a hard scale. Therefore it is interesting to compare such predictions to results using photoproduction events where a low-virtuality photon, emitted by the incoming lepton, collides with a parton from the incoming proton. A measurement of beauty in photoproduction has been made at HERA with the ZEUS detector using an integrated luminosity of 126 pb{sup -}1. Beauty was identified in events with a muon in the final state by using the transverse momentum of the muon relative to the closest jet. Lifetime information from the silicon vertex detector was also used; the impact parameter of the muon with respect to the primary vertex was exploited to discriminate between signal and background. Cross sections for beauty production as a function of the muon and the jet variables were measured and compared to QCD predictions and to previous measurements. The data were found to be well described by the predictions from next-to-leading-order QCD. The dijet sample of beauty photoproduction events was also used to study higher-order QCD topologies. At leading order, the two jets in the event are produced back-to-back in azimuthal angle, such that {delta}{phi}{sup jj}={phi}{sup j1}-{phi}{sup j2}={pi}. Additional soft radiation causes small azimuthal decorrelations, whilst {delta}{phi}{sup jj} significantly lower than {pi} is evidence of additional hard radiation. In this thesis, the cross section versus {delta}{phi}{sup jj} for beauty photoproduction and the comparison to NLO QCD predictions and Monte Carlo models are presented. (orig.)

  11. Beauty in photoproduction at HERA II with the ZEUS detector

    International Nuclear Information System (INIS)

    The production of beauty quarks in ep collisions should be accurately calculable in perturbative Quantum Chromodynamics (QCD) since the large mass of the b quark provides a hard scale. Therefore it is interesting to compare such predictions to results using photoproduction events where a low-virtuality photon, emitted by the incoming lepton, collides with a parton from the incoming proton. A measurement of beauty in photoproduction has been made at HERA with the ZEUS detector using an integrated luminosity of 126 pb-1. Beauty was identified in events with a muon in the final state by using the transverse momentum of the muon relative to the closest jet. Lifetime information from the silicon vertex detector was also used; the impact parameter of the muon with respect to the primary vertex was exploited to discriminate between signal and background. Cross sections for beauty production as a function of the muon and the jet variables were measured and compared to QCD predictions and to previous measurements. The data were found to be well described by the predictions from next-to-leading-order QCD. The dijet sample of beauty photoproduction events was also used to study higher-order QCD topologies. At leading order, the two jets in the event are produced back-to-back in azimuthal angle, such that Δφjj=φj1-φj2=π. Additional soft radiation causes small azimuthal decorrelations, whilst Δφjj significantly lower than π is evidence of additional hard radiation. In this thesis, the cross section versus Δφjj for beauty photoproduction and the comparison to NLO QCD predictions and Monte Carlo models are presented. (orig.)

  12. Beauty is as beauty does: body image and self-esteem of pageant contestants.

    Science.gov (United States)

    Thompson, S H; Hammond, K

    2003-09-01

    Self-esteem, dieting, and body image of 131 female beauty pageant contestants (mean age 26.0 years) from 43 states were examined by an anonymous survey. Most (89.6%) reported being a pageant finalist or winner and 55.2% had competed at the nationa/international level Over one-fourth (26%) of the women had been told or perceived they had an eating disorder which reportedly began at 16.25 years. Almost half (48.5%) reported wanting to be thinner and 57% were trying to lose weight. Higher self-esteem scores were significantly associated with increased level of competition (i.e.: from local to international pageants), but not with the number of times the women were pageant finalists or winners. Future study is warranted to determine how pageant participation influences self-esteem, body image, and the development of eating disorders. PMID:14649788

  13. Online Beauty Sites Face Uncertain Future(iSyndicate News)

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    This week’s announcements that e-tailersGloss.com and Beautyscene.com are up for sale are astrong indication that online beauty products firms willbe among the early victims of the projected e-commerceshakeout.“With the plethora of beauty sites out there,it hasall come down to which few are going to survive,”saidLisa Allen,an analyst with Forrester Research.“Onlythose with strong brand presence,a solid customer baseand a bricks-and-mortar presence will be around in thelong term.”

  14. CP violation in charm and beauty decays at LHCb

    Energy Technology Data Exchange (ETDEWEB)

    Pepe Altarelli, M., E-mail: monica.pepe.altarelli@cern.ch

    2013-08-15

    LHCb is a dedicated heavy flavour physics precision experiment at the LHC searching for New Physics (NP) beyond the Standard Model (SM) through the study of very rare decays of beauty and charm-flavoured hadrons and precision measurements of CP-violating observables. In this review I will present a selection of recent precision measurements of CP-violating observables in the decays of beauty and charm-flavoured hadrons. These measurements are based on an integrated luminosity of up to 1.0 fb{sup −1} collected by LHCb in 2011.

  15. Simple estimates of the hidden beauty pentaquarks masses

    CERN Document Server

    Kopeliovich, Vladimir

    2015-01-01

    The masses of cryptoexotic pentaquarks with hidden beauty are estimated phenomenologically using the results by the LHCb collaboration which discovered recently the cryptoexotic pentaquarks with hidden charm. The expected masses of the hidden beauty pentaquarks are about $10.8\\, GeV$ and $10.7\\,GeV$ in the limit of some kind of heavy quark symmetry. The states with hidden strangeness considered in similar way have masses above $2\\, Gev$, by several hundreds of $MeV$ higher than states discussed previously in connection with the relatively light positive strangeness pentaquark $\\theta^+$.

  16. Open charm and beauty production in hadron reactions

    Energy Technology Data Exchange (ETDEWEB)

    Lykasov, G.I.; Lyubushkin, V.V.; Bednyakov, V.A. [Joint Institute for Nuclear Research, 141980, Dubna, Moscow region (Russian Federation)

    2010-01-15

    The production of charmed and beauty hadrons in proton-proton and proton-antiproton collisions at high energies is analyzed within the modified quark-gluon string model (QGSM) including the internal motion of quarks in colliding hadrons. It is shown that using both the QGSM and NLO QCD one can describe these experimental data rather successfully in a wide region of transverse momenta. We also present some predictions for the future experiments on the beauty baryon production in pp collisions at LHC energies and on the charmed meson production in p-bar p reactions at GSI energies.

  17. CP violation in charm and beauty decays at LHCb

    Science.gov (United States)

    Pepe Altarelli, M.

    2013-08-01

    LHCb is a dedicated heavy flavour physics precision experiment at the LHC searching for New Physics (NP) beyond the Standard Model (SM) through the study of very rare decays of beauty and charm-flavoured hadrons and precision measurements of CP-violating observables. In this review I will present a selection of recent precision measurements of CP-violating observables in the decays of beauty and charm-flavoured hadrons. These measurements are based on an integrated luminosity of up to 1.0 fb collected by LHCb in 2011.

  18. Beauty and charm production in fixed target experiments

    International Nuclear Information System (INIS)

    We present calculations of NNLO threshold corrections for beauty and charm production in π- p and pp interactions at fixed-target experiments. Recent calculations for heavy quark hadroproduction have included next-to-next-to-leading-order (NNLO) soft-gluon corrections [1] to the double differential cross section from threshold resummation techniques [2]. These corrections are important for near-threshold beauty and charm production at fixed-target experiments, including HERA-B and some of the current and future heavy ion experiments

  19. CP violation in charm and beauty decays at LHCb

    International Nuclear Information System (INIS)

    LHCb is a dedicated heavy flavour physics precision experiment at the LHC searching for New Physics (NP) beyond the Standard Model (SM) through the study of very rare decays of beauty and charm-flavoured hadrons and precision measurements of CP-violating observables. In this review I will present a selection of recent precision measurements of CP-violating observables in the decays of beauty and charm-flavoured hadrons. These measurements are based on an integrated luminosity of up to 1.0 fb−1 collected by LHCb in 2011

  20. Beauty, charm and hyperon production at fixed-target experiments

    Energy Technology Data Exchange (ETDEWEB)

    Erik Gottschalk

    2002-12-11

    Over the years fixed-target experiments have performed numerous studies of particle production in strong interactions. The experiments have been performed with different types of beam particles of varying energies, and many different target materials. Since the physics of particle production is still not understood, ongoing research of phenomena that we observe as beauty, charm and strange-particle production is crucial if we are to gain an understanding of these fundamental processes. It is in this context that recent results from fixed-target experiments on beauty, charm, and hyperon production will be reviewed.

  1. Beauty photoproduction using decays into electrons at HERA

    International Nuclear Information System (INIS)

    Photoproduction of beauty quarks in events with two jets and an electron associated with one of the jets has been studied with the ZEUS detector at HERA using an integrated luminosity of 120 pb-1. The fractions of events containing b quarks, and also of events containing c quarks, were extracted from a likelihood fit using variables sensitive to electron identification as well as to semileptonic decays. Total and differential cross sections for beauty and charm production were measured and compared with next-to-leading-order QCD calculations and Monte Carlo models. (orig.)

  2. Beautiful Data The Stories Behind Elegant Data Solutions

    CERN Document Server

    Segaran, Toby

    2009-01-01

    In this insightful book, you'll learn from the best data practitioners in the field just how wide-ranging -- and beautiful -- working with data can be. Join 39 contributors as they explain how they developed simple and elegant solutions on projects ranging from the Mars lander to a Radiohead video. With Beautiful Data, you will: Explore the opportunities and challenges involved in working with the vast number of datasets made available by the WebLearn how to visualize trends in urban crime, using maps and data mashupsDiscover the challenges of designing a data processing system that works wi

  3. Improving competitiveness of Daisy.Queen Beauty Salon

    OpenAIRE

    Li, Yan

    2012-01-01

    The purpose of this thesis was to conduct a case study through some surveys and recommendations. The aim of the study was to find competitor‟s advantages, then it could provide recommendations and ways to Daisy.Queen beauty salon to be more attractive and competitive. The theoretical part of thesis include the importance of service, the seven P‟s of service marketing, the importance of service marketing in beauty industry. The seven P‟s of service marketing was analyzed and supported to th...

  4. Beauty production with the ZEUS HERA II data

    International Nuclear Information System (INIS)

    Beauty production has been measured with the ZEUS detector at HERA II using e+ p data collected in 2003/04. Two preliminary measurements of beauty production in events containing jets and a muon are presented. The first exploits the new ZEUS microvertex detector to measure the b content in photoproduction events by means of the muon impact parameter and its transverse momentum relative to the closest jet. The second measurement determines the b content of DIS events by using the relative transverse momentum of the muon alone. The results of both measurements were found to be in agreement with previous results and with QCD predictions. (author)

  5. The beautiful infant and Israel’s salvation

    OpenAIRE

    James A. Loader

    2011-01-01

    The motif from the Exodus story of Moses as a beautiful infant is considered on several levels. Firstly, the immediate context of Exodus 2 in the Hebrew Bible and in the Septuagint is investigated. Exodus 2 is then related to the reception of the tradition in the New Testament and Jewish sources as well as in a patristic reading and one from the Reformation. The article concludes that the motif of Moses’ beauty is part of a relatively infrequent but nevertheless well-established constellation...

  6. Beautiful Testing Leading Professionals Reveal How They Improve Software

    CERN Document Server

    Goucher, Adam

    2009-01-01

    Successful software depends as much on scrupulous testing as it does on solid architecture or elegant code. But testing is not a routine process, it's a constant exploration of methods and an evolution of good ideas. Beautiful Testing offers 23 essays from 27 leading testers and developers that illustrate the qualities and techniques that make testing an art. Through personal anecdotes, you'll learn how each of these professionals developed beautiful ways of testing a wide range of products -- valuable knowledge that you can apply to your own projects. Here's a sample of what you'll find i

  7. 75 FR 10345 - Pricing for 2010 United States Mint America the Beautiful Quarters Proof Set, etc.

    Science.gov (United States)

    2010-03-05

    ... United States Mint Pricing for 2010 United States Mint America the Beautiful Quarters Proof Set, etc... is announcing the prices of the 2010 United States Mint America the Beautiful Quarters Proof Set; 2010 United States Mint America the Beautiful Quarters Silver Proof Set; 2010 United States...

  8. Measurement of beauty quark mass at HERA and impact on Higgs production in association with beauty quarks at LHC

    Energy Technology Data Exchange (ETDEWEB)

    Gizhko, Andrii

    2016-06-15

    Three different, but related topics are the subject of this thesis, performed in the context of the ZEUS and CMS groups at DESY. The first measurement of the MS beauty-quark mass m{sub b}(m{sub b}) at an electron-proton collider is presented. The measurement is based on a QCD analysis of beauty production cross sections in deep inelastic (DIS) ep scattering measured by ZEUS at HERA, together with inclusive DIS HERA data, using Next-to-Leading-Order QCD predictions. The measured value of the running beauty-quark mass in the MS scheme was found to be m{sub b}(m{sub b})=4.07±0.14 (fit){sup +0.01}{sub -0.07}(mod.){sup +0.05}{sub -0.00}(param.){sup +0.08}{sub -0.05}( theo.) GeV, which is in good agreement with the world average Particle Data Group value and previous measurements at electron-positron colliders. It is also found to be consistent with the expected running of m{sub b}(μ). A first measurement of the charm-quark mass m{sub c}(μ) running in the MS scheme is presented. The measurement is based on a QCD analysis of the published H1 and ZEUS combination of charm cross section measurements in DIS ep scattering at HERA, together with inclusive DIS HERA data, using Next-to-Leading-Order QCD predictions. The running charm-quark mass m{sub c}(μ) was measured at different scales μ and is presented in a charm-quark mass running plot with a comparison to the world average Particle Data Group m{sub c}(m{sub c}) evolved to higher scales. The running is found to be consistent with the expectations from QCD. The uncertainties of the theoretical predictions for Higgs production in association with beauty-quarks originating from the beauty-quark mass were studied and reduced for massive and massless QCD calculations. The beauty-quark mass measurement m{sub b}(m{sub b}) was used to decrease the variation of the beauty-quark mass to 0.17 GeV. It was shown that the uncertainty from the beauty-quark mass m{sub b}(m{sub b}) in the case of massive calculations for Hb anti b

  9. Charm and Beauty Production from Semileptonic Decays at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Juengst, Markus [Universitaet Bonn (Germany)

    2010-07-01

    Measurement of the photoproduction of b-quarks at threshold at HERA The cross section of bb-bar photoproduction in ep collisions is measured with the H1 detector at HERA. Events containing b-quarks are identified through detection of two low momentum electrons in the final state. Semileptonic decays bb-bar {yields} ee X are exploited in the kinematic range of the photon virtuality Q{sup 2} < 1 GeV{sup 2}, the inelasticity 0.2 < y < 0.8 and the pseudorapidity of the b-quarks |{eta}(b), {eta}(b-bar)| < 2. The differential b-quark production cross section is measured as a function of the transverse b-quark momentum and extends the previously experimentally accessible phase space towards the b-quark production threshold. The results are compared to other b-quark cross section measurements, as well as to QCD predictions. Measurement of charm and beauty production in deep inelastic ep scattering from decays into muons at HERA The production of charm and beauty quarks in ep interactions has been measured with the ZEUS detector at HERA for squared four-momentum exchange Q{sup 2}>20 GeV{sup 2}, using an integrated luminosity of 126 pb{sup -1}. Charm and beauty quarks were identified through their decays into muons. Differential cross sections were measured for muon transverse momenta p{sub T}{sup {mu}>}1.5 GeV and pseudo-rapidities -1.6<{eta}{sup {mu}<}2.3, as a function of p{sub T}{sup {mu}}, {eta}{sup {mu}}, Q{sup 2} and Bjorken x. The charm and beauty contributions to the proton structure function F{sub 2} were also extracted. The results agree with previous measurements based on independent techniques and are well described by QCD predictions. Measurement of beauty production in DIS and F2b b-bar extraction at ZEUS Beauty production in deep inelastic scattering with events in which a muon and a jet are observed in the final state has been measured with the ZEUS detector at HERA using an integrated luminosity of 114 pb{sup -1}. The fraction of events with beauty quarks

  10. Media, Construction and Deconstruction of Beauty Myth : – A Case Study of Dove’s Real Beauty Campaign

    OpenAIRE

    Zhang, Xiaohui

    2010-01-01

    The paper examines the media portrayal of real women in Dove’s Real Beauty Campaign. Through the semiotic analysis and reception analysis of the ad “Evolution”, the author investigates how Dove attempts to challenge the myth in most beauty advertising and present the “real beauty” idea to the audiences. The study further discusses about the gender issues aroused from the campaign. The findings show that the untouchable images of women are created under the pressures of male-dominated culture....

  11. Neural correlates of visual aesthetics--beauty as the coalescence of stimulus and internal state.

    Science.gov (United States)

    Jacobs, Richard H A H; Renken, Remco; Cornelissen, Frans W

    2012-01-01

    How do external stimuli and our internal state coalesce to create the distinctive aesthetic pleasures that give vibrance to human experience? Neuroaesthetics has so far focused on the neural correlates of observing beautiful stimuli compared to neutral or ugly stimuli, or on neural correlates of judging for beauty as opposed to other judgments. Our group questioned whether this approach is sufficient. In our view, a brain region that assesses beauty should show beauty-level-dependent activation during the beauty judgment task, but not during other, unrelated tasks. We therefore performed an fMRI experiment in which subjects judged visual textures for beauty, naturalness and roughness. Our focus was on finding brain activation related to the rated beauty level of the stimuli, which would take place exclusively during the beauty judgment. An initial whole-brain analysis did not reveal such interactions, yet a number of the regions showing main effects of the judgment task or the beauty level of stimuli were selectively sensitive to beauty level during the beauty task. Of the regions that were more active during beauty judgments than roughness judgments, the frontomedian cortex and the amygdala demonstrated the hypothesized interaction effect, while the posterior cingulate cortex did not. The latter region, which only showed a task effect, may play a supporting role in beauty assessments, such as attending to one's internal state rather than the external world. Most of the regions showing interaction effects of judgment and beauty level correspond to regions that have previously been implicated in aesthetics using different stimulus classes, but based on either task or beauty effects alone. The fact that we have now shown that task-stimulus interactions are also present during the aesthetic judgment of visual textures implies that these areas form a network that is specifically devoted to aesthetic assessment, irrespective of the stimulus type. PMID:22384006

  12. Neural correlates of visual aesthetics--beauty as the coalescence of stimulus and internal state.

    Directory of Open Access Journals (Sweden)

    Richard H A H Jacobs

    Full Text Available How do external stimuli and our internal state coalesce to create the distinctive aesthetic pleasures that give vibrance to human experience? Neuroaesthetics has so far focused on the neural correlates of observing beautiful stimuli compared to neutral or ugly stimuli, or on neural correlates of judging for beauty as opposed to other judgments. Our group questioned whether this approach is sufficient. In our view, a brain region that assesses beauty should show beauty-level-dependent activation during the beauty judgment task, but not during other, unrelated tasks. We therefore performed an fMRI experiment in which subjects judged visual textures for beauty, naturalness and roughness. Our focus was on finding brain activation related to the rated beauty level of the stimuli, which would take place exclusively during the beauty judgment. An initial whole-brain analysis did not reveal such interactions, yet a number of the regions showing main effects of the judgment task or the beauty level of stimuli were selectively sensitive to beauty level during the beauty task. Of the regions that were more active during beauty judgments than roughness judgments, the frontomedian cortex and the amygdala demonstrated the hypothesized interaction effect, while the posterior cingulate cortex did not. The latter region, which only showed a task effect, may play a supporting role in beauty assessments, such as attending to one's internal state rather than the external world. Most of the regions showing interaction effects of judgment and beauty level correspond to regions that have previously been implicated in aesthetics using different stimulus classes, but based on either task or beauty effects alone. The fact that we have now shown that task-stimulus interactions are also present during the aesthetic judgment of visual textures implies that these areas form a network that is specifically devoted to aesthetic assessment, irrespective of the stimulus type.

  13. Neural Correlates of Visual Aesthetics – Beauty as the Coalescence of Stimulus and Internal State

    Science.gov (United States)

    Jacobs, Richard H. A. H.; Renken, Remco; Cornelissen, Frans W.

    2012-01-01

    How do external stimuli and our internal state coalesce to create the distinctive aesthetic pleasures that give vibrance to human experience? Neuroaesthetics has so far focused on the neural correlates of observing beautiful stimuli compared to neutral or ugly stimuli, or on neural correlates of judging for beauty as opposed to other judgments. Our group questioned whether this approach is sufficient. In our view, a brain region that assesses beauty should show beauty-level-dependent activation during the beauty judgment task, but not during other, unrelated tasks. We therefore performed an fMRI experiment in which subjects judged visual textures for beauty, naturalness and roughness. Our focus was on finding brain activation related to the rated beauty level of the stimuli, which would take place exclusively during the beauty judgment. An initial whole-brain analysis did not reveal such interactions, yet a number of the regions showing main effects of the judgment task or the beauty level of stimuli were selectively sensitive to beauty level during the beauty task. Of the regions that were more active during beauty judgments than roughness judgments, the frontomedian cortex and the amygdala demonstrated the hypothesized interaction effect, while the posterior cingulate cortex did not. The latter region, which only showed a task effect, may play a supporting role in beauty assessments, such as attending to one's internal state rather than the external world. Most of the regions showing interaction effects of judgment and beauty level correspond to regions that have previously been implicated in aesthetics using different stimulus classes, but based on either task or beauty effects alone. The fact that we have now shown that task-stimulus interactions are also present during the aesthetic judgment of visual textures implies that these areas form a network that is specifically devoted to aesthetic assessment, irrespective of the stimulus type. PMID:22384006

  14. Neural correlates of visual aesthetics--beauty as the coalescence of stimulus and internal state.

    Science.gov (United States)

    Jacobs, Richard H A H; Renken, Remco; Cornelissen, Frans W

    2012-01-01

    How do external stimuli and our internal state coalesce to create the distinctive aesthetic pleasures that give vibrance to human experience? Neuroaesthetics has so far focused on the neural correlates of observing beautiful stimuli compared to neutral or ugly stimuli, or on neural correlates of judging for beauty as opposed to other judgments. Our group questioned whether this approach is sufficient. In our view, a brain region that assesses beauty should show beauty-level-dependent activation during the beauty judgment task, but not during other, unrelated tasks. We therefore performed an fMRI experiment in which subjects judged visual textures for beauty, naturalness and roughness. Our focus was on finding brain activation related to the rated beauty level of the stimuli, which would take place exclusively during the beauty judgment. An initial whole-brain analysis did not reveal such interactions, yet a number of the regions showing main effects of the judgment task or the beauty level of stimuli were selectively sensitive to beauty level during the beauty task. Of the regions that were more active during beauty judgments than roughness judgments, the frontomedian cortex and the amygdala demonstrated the hypothesized interaction effect, while the posterior cingulate cortex did not. The latter region, which only showed a task effect, may play a supporting role in beauty assessments, such as attending to one's internal state rather than the external world. Most of the regions showing interaction effects of judgment and beauty level correspond to regions that have previously been implicated in aesthetics using different stimulus classes, but based on either task or beauty effects alone. The fact that we have now shown that task-stimulus interactions are also present during the aesthetic judgment of visual textures implies that these areas form a network that is specifically devoted to aesthetic assessment, irrespective of the stimulus type.

  15. Cosmetology Curriculum and Training as Seen by Beauty Salons.

    Science.gov (United States)

    San Mateo Coll., CA.

    To evaluate the effectiveness of its cosmetology program, the College of San Mateo sent a questionnaire to beauty salons in the college's service area. Of the 70 questionnaires sent, over half were returned. Eleven courses in the curriculum were ranked by the employer in order of importance to him, the first four being the 1,600 hours of…

  16. Identification of beauty and charm quark jets at LHCb

    NARCIS (Netherlands)

    Aaij, R.; Adeva, B.; Adinolfi, M.; Affolder, A.; Ajaltouni, Z.; Akar, S.; Albrecht, J.; Alessio, F.; Alexander, M.; Ali, S.; Alkhazov, G.; Cartelle, P. Alvarez; Alves, A. A.; Amato, S.; Amerio, S.; Amhis, Y.; An, L.; Anderlini, L.; Andreotti, M.; Andrews, J. E.; Appleby, R. B.; Gutierrez, O. Aquines; Archilli, F.; d'Argent, P.; Artamonov, A.; Artuso, M.; Aslanides, E.; Auriemma, G.; Baalouch, M.; Bachmann, S.; Back, J. J.; Badalov, A.; Baesso, C.; Baldini, W.; Barlow, R. J.; Barschel, C.; Barsuk, S.; Barter, W.; Batozskaya, V.; Battista, V.; Beaucourt, L.; Beddow, J.; Bedeschi, F.; Bediaga, I.; Bel, L. J.; Belyaev, I.; Ben-Haim, E.; Bencivenni, G.; Benson, S.; Benton, J.; Berezhnoy, A.; Bernet, R.; Bertolin, A.; Bettler, M. O.; van Beuzekom, M.; Bien, A.; Bifani, S.; Bird, T.; Birnkraut, A.; Bizzeti, A.; Blake, T.; Blanc, F.; Blouw, J.; Blusk, S.; Bocci, V.; Bondar, A.; Bondar, N.; Bonivento, W.; Borghi, S.; Borsato, M.; Bowcock, T. J. V.; Bowen, E.; Bozzi, C.; Braun, S.; Brett, D.; Britsch, M.; Britton, T.; Brodzicka, J.; Brook, N. H.; Bursche, A.; Buytaert, J.; Cadeddu, S.; Calabrese, R.; Calvi, M.; Calvo Gomez, M.; Campana, P.; Perez, D. Campora; Capriotti, L.; Carbone, A.; Carboni, G.; Cardinale, R.; Cardini, A.; Carniti, P.; Carson, L.; Carvalho Akiba, K.; Casanova Mohr, R.; Casse, G.; Cassina, L.; Garcia, L. Castillo; Cattaneo, M.; Cauet, Ch.; Cavallero, G.; Cenci, R.; Charles, M.; Charpentier, Ph.; Chefdeville, M.; Cheung, S. F.; Chiapolini, N.; Chrzaszcz, M.; Vidal, X. Cid; Ciezarek, G.; Clarke, P. E. L.; Clemencic, M.; Cliff, H. V.; Closier, J.; Coco, V.; Cogan, J.; Cogneras, E.; Cogoni, V.; Cojocariu, L.; Collazuol, G.; Collins, P.; Comerma-Montells, A.; Contu, A.; Cook, A.; Coombes, M.; Coquereau, S.; Corti, G.; Corvo, M.; Counts, I.; Couturier, B.; Cowan, G. A.; Craik, D. C.; Crocombe, A.; Cruz Torres, M.; Cunliffe, S.; Currie, R.; D'Ambrosio, C.; Dalseno, J.; David, P. N. Y.; Davis, A.; De Bruyn, K.; De Capua, S.; De Cian, M.; De Miranda, J. M.; De Paula, L.; De Silva, W.; De Simone, P.; Dean, C. T.; Decamp, D.; Deckenhoff, M.; Del Buono, L.; Deleage, N.; Derkach, D.; Deschamps, O.; Dettori, F.; Dey, B.; Di Canto, A.; Di Ruscio, F.; Donleavy, S.; Dordei, F.; Dorigo, M.; Dosil Suarez, A.; Dossett, D.; Dovbnya, A.; Dreimanis, K.; Dufour, L.; Dujany, G.; Dupertuis, F.; Durante, P.; Dzhelyadin, R.; Dziurda, A.; Dzyuba, A.; Easo, S.; Egede, U.; Egorychev, V.; Eidelman, S.; Eisenhardt, S.; Eitschberger, U.; Ekelhof, R.; Eklund, L.; El Rifai, I.; Elsasser, Ch.; Ely, S.; Esen, S.; Evans, H. M.; Evans, T.; Falabella, A.; Faerber, C.; Farinelli, C.; Farley, N.; Farry, S.; Fay, R.; Ferguson, D.; Fernandez Albor, V.; Ferrari, F.; Ferreira Rodrigues, F.; Ferro-Luzzi, M.; Filippov, S.; Fiore, M.; Fiorini, M.; Firlej, M.; Fitzpatrick, C.; Fiutowski, T.; Fohl, K.; Fol, P.; Fontana, M.; Fontanelli, F.; Forty, R.; Francisco, O.; Frei, C.; Frosini, M.; Furfaro, E.; Gallas Torreira, A.; Galli, D.; Gallorini, S.; Gambetta, S.; Gandelman, M.; Gandini, P.; Garcia Pardinas, J.; Garofoli, J.; Tico, J. Garra; Garrido, L.; Gascon, D.; Gaspar, C.; Gastaldi, U.; Gauld, R.; Gavardi, L.; Gazzoni, G.; Geraci, A.; Gerick, D.; Gersabeck, E.; Gersabeck, M.; Gershon, T.; Ghez, Ph.; Gianelle, A.; Giani, S.; Gibson, V.; Girard, O. G.; Giubega, L.; Gligorov, V. V.; Goebel, C.; Golubkov, D.; Golutvin, A.; Gotti, C.; Gandara, M. Grabalosa; Graciani Diaz, R.; Cardoso, L. A. Granado; Grauges, E.; Graverini, E.; Graziani, G.; Grecu, A.; Greening, E.; Gregson, S.; Griffith, P.; Grillo, L.; Gruenberg, O.; Gui, B.; Gushchin, E.; Guz, Yu.; Gys, T.; Hadjivasiliou, C.; Haefeli, G.; Haen, C.; Haines, S. C.; Hall, S.; Hamilton, B.; Hampson, T.; Han, X.; Hansmann-Menzemer, S.; Harnew, N.; Harnew, S. T.; Harrison, J.; He, J.; Head, T.; Heijne, V.; Hennessy, K.; Henrard, P.; Henry, L.; Hernando Morata, J. A.; van Herwijnen, E.; Hess, M.; Hicheur, A.; Hill, D.; Hoballah, M.; Hombach, C.; Hulsbergen, W.; Humair, T.; Hussain, N.; Hutchcroft, D.; Hynds, D.; Idzik, M.; Ilten, P.; Jacobsson, R.; Jalocha, J.; Jans, E.; Jawahery, A.; Jing, F.; John, M.; Johnson, D.; Jones, C. R.; Joram, C.; Jost, B.; Jurik, N.; Kandybei, S.; Kanso, W.; Karacson, M.; Karbach, T. M.; Karodia, S.; Kelsey, M.; Kenyon, I. R.; Kenzie, M.; Ketel, T.; Khanji, B.; Khurewathanakul, C.; Klaver, S.; Klimaszewski, K.; Kochebina, O.; Kolpin, M.; Komarov, I.; Koppenburg, P.; Korolev, M.; Kravchuk, L.; Kreplin, K.; Kreps, M.; Krocker, G.; Krokovny, P.; Kucewicz, W.; Kucharczyk, M.; Kudryavtsev, V.; Kuonen, A. K.; Kurek, K.; Kvaratskheliya, T.; La Thi, V. N.; Lacarrere, D.; Lafferty, G.; Lai, A.; Lambert, D.; Lambert, R. W.; Lanfranchi, G.; Langenbruch, C.; Langhans, B.; Latham, T.; Lazzeroni, C.; Le Gac, R.; van Leerdam, J.; Lees, J. P.; Lefevre, R.; Leflat, A.; Lefrancois, J.; Leroy, O.

    2015-01-01

    Identification of jets originating from beauty and charm quarks is important for measuring Standard Model processes and for searching for new physics. The performance of algorithms developed to select b- and c-quark jets is measured using data recorded by LHCb from proton-proton collisions at root s

  17. A hyperactive sleeping beauty transposase enhances transgenesis in zebrafish embryos

    Directory of Open Access Journals (Sweden)

    Lardelli Michael

    2010-11-01

    Full Text Available Abstract Background Transposons are useful molecular tools for transgenesis. The 'sleeping beauty' transposon is a synthetic member of the Tc1/mariner transposon family. Davidson et al. (2003 previously described a vector for zebrafish transgenesis consisting of the inverted repeats of 'sleeping beauty' flanking the gene to be transposed. Subsequently, there have been attempts to enhance the transpositional activity of 'sleeping beauty' by increasing the activity of its transposase. Recently, Mates et al. (2009 generated a hyperactive transposase giving a 100-fold increased transposition rate in mouse embryos. Findings The aim of this experiment was to determine whether this novel hyperactive transposase enhances transgenesis in zebrafish embryos. Using our previously characterised mitfa-amyloidβ-GFP transgene, we observed an eight-fold enhancement in transient transgenesis following detection of transgene expression in melanophores by whole mount in-situ hybridisation. However, high rates of defective embryogenesis were also observed. Conclusion The novel hyperactive 'sleeping beauty' transposase enhances the rate of transgenesis in zebrafish embryos.

  18. Beauty vector meson decay constants from QCD sum rules

    Energy Technology Data Exchange (ETDEWEB)

    Lucha, Wolfgang [Institute for High Energy Physics, Austrian Academy of Sciences, Nikolsdorfergasse 18, A-1050 Vienna (Austria); Melikhov, Dmitri [Institute for High Energy Physics, Austrian Academy of Sciences, Nikolsdorfergasse 18, A-1050 Vienna (Austria); D. V. Skobeltsyn Institute of Nuclear Physics, M. V. Lomonosov Moscow State University, 119991, Moscow (Russian Federation); Simula, Silvano [Istituto Nazionale di Fisica Nucleare, Sezione di Roma Tre, Via della Vasca Navale 84, I-00146, Roma (Italy)

    2016-01-22

    We present the outcomes of a very recent investigation of the decay constants of nonstrange and strange heavy-light beauty vector mesons, with special emphasis on the ratio of any such decay constant to the decay constant of the corresponding pseudoscalar meson, by means of Borel-transformed QCD sum rules. Our results suggest that both these ratios are below unity.

  19. Beauty Vector Meson Decay Constants from QCD Sum Rules

    CERN Document Server

    Lucha, Wolfgang; Simula, Silvano

    2016-01-01

    We present the outcomes of a very recent investigation of the decay constants of nonstrange and strange heavy-light beauty vector mesons, with special emphasis on the ratio of any such decay constant to the decay constant of the corresponding pseudoscalar meson, by means of Borel-transformed QCD sum rules. Our results suggest that both these ratios are below unity.

  20. Rare decays of beauty and charm hadrons at LHCb

    CERN Document Server

    Serrano, Justine

    2013-01-01

    Rare decays of heavy hadrons, in particular flavour changing neutral currents, forbidden at the tree level in the Standard Model, are highly sensitive to the presence of possible new particles circulating in loop diagrams. A review of the latest LHCb results on rare decays of beauty and charm hadrons is presented.

  1. Masses and couplings of open beauty states in QCD

    International Nuclear Information System (INIS)

    Masses and couplings of open beauty states (strange and non-strange) with Jsup(PC) = 0++, 0-+, 1--. and 1++ are calculated using the QCD sum rule formalism. Non-perturbative effects due to quark and gluon condensate operators are shown to be important, confirming earlier calculations for equal quark mass systems. (author)

  2. Beauty vector meson decay constants from QCD sum rules

    International Nuclear Information System (INIS)

    We present the outcomes of a very recent investigation of the decay constants of nonstrange and strange heavy-light beauty vector mesons, with special emphasis on the ratio of any such decay constant to the decay constant of the corresponding pseudoscalar meson, by means of Borel-transformed QCD sum rules. Our results suggest that both these ratios are below unity

  3. The "F" Word: Is Feminism Incompatible with Beauty and Romance?

    Science.gov (United States)

    Rudman, Laurie A.; Fairchild, Kimberly

    2007-01-01

    Three studies examined the predictive utility of heterosexual relationship concerns vis-a-vis support for feminism. Study 1 showed that beauty is perceived to be at odds with feminism, for both genders. The stereotype that feminists are unattractive was robust, but fully accounted for by romance-related attributions. Moreover, more attractive…

  4. Jie Chen—The beauty in Her Study

    Institute of Scientific and Technical Information of China (English)

    Willow

    2004-01-01

    Reading,wriing and watching movies,are ddefined as"activities in her study"by Jie Chen,a beautiful writer,editor,and film riviewer,well known mationwide.As one of the liading representatives of essay creation in China,Jie Chen started her career as a uourmalist in Chengdu Evening.After her successful

  5. Beauty vector meson decay constants from QCD sum rules

    Science.gov (United States)

    Lucha, Wolfgang; Melikhov, Dmitri; Simula, Silvano

    2016-01-01

    We present the outcomes of a very recent investigation of the decay constants of nonstrange and strange heavy-light beauty vector mesons, with special emphasis on the ratio of any such decay constant to the decay constant of the corresponding pseudoscalar meson, by means of Borel-transformed QCD sum rules. Our results suggest that both these ratios are below unity.

  6. Antiviral Polymer Therapeutics

    DEFF Research Database (Denmark)

    Smith, Anton Allen Abbotsford

    2014-01-01

    and the drug which increased the potency of the conjugates significantly. A different approach to drug delivery is that of surface mediated drug delivery. Hydrogels of poly(vinyl alcohol) has shown great promise in this regard. The chemical opportunities of this polymer are explored through the virtues...... of reversible-addition-fragmentation chain transfer polymerization, which not only controls the size of polymer, but also allows the introduction of a terminal amine on the polymer which can be used for further conjugation. This has allowed for not only fluorescent labeling of the polymer, but also protein......The field of drug delivery is in essence an exercise in engineered pharmacokinetics. Methods of doing so have been developed through the introduction of a vehicle carrying the drug, either by encapsulation or covalent attachment. The emergence of polymer therapeutics in anticancer therapy has...

  7. Asymmetry and Symmetry in the Beauty of Human Faces

    Directory of Open Access Journals (Sweden)

    Marjan Hessamian

    2010-02-01

    Full Text Available The emphasis in the published literature has mostly been on symmetry as the critical source for beauty judgment. In fact, both symmetry and asymmetry serve as highly aesthetic sources of beauty, whether the context is perceptual or conceptual. The human brain is characterized by symbolic cognition and this type of cognition facilitates a range of aesthetic reactions. For example, both art and natural scenery contain asymmetrical elements, which nevertheless render the whole effect beautiful. A further good case in point is, in fact, human faces. Normally, faces are structurally left-right symmetrical content-wise but not size-wise or function-wise. Attractiveness has often been discussed in terms of content-wise full-face symmetry. To test whether or not attractiveness can be gleaned only from the presence of left-right full-faces we tested half faces. Three separate groups of participants viewed and rated the attractiveness of 56 full-faces (women’s and men’s, their 56 vertical left hemi-faces and 56 vertical right hemi-faces. We found no statistically significant differences in the attractiveness ratings of full- and hemi-faces (whether left or right. Instead, we found a strong and significant positive correlation between the ratings of the hemi- and full-faces. These results are consistent with the view that the underpinning of human facial beauty is complex and that bilateral symmetry does not constitute a principle factor in beauty assessment. We discuss that the highly evolved human brain, compared to other animals, as well as symbolic and abstract cognition in humans enable a wide variety of aesthetic reactions.

  8. Therapeutics aspects of music education

    OpenAIRE

    Pesek, Albinca; Čagran, Branka

    2015-01-01

    Disintegration of moral value system in modern society demands changes of educational system. Education takes an important part with its effort to establish integral education. In this way, an individual develops all his potentials: physical, emotional, cognitive and mental. Music education in its therapeutic mission helps at forming harmonious personality and becomes a mediator at different activities where discrepancies do not allow a successful educational process. On the basis of the empi...

  9. Measurement of beauty and charm production in deep inelastic scattering at HERA and measurement of the beauty-quark mass

    Energy Technology Data Exchange (ETDEWEB)

    Abramowicz, H. [Tel Aviv Univ. (Israel). School of Physics; Max Planck Institute for Physics, Munich (Germany); Abt, I. [Max Planck Institute for Physics, Munich (Germany); Adamczyk, L. [AGH-Univ. of Science and Technology, Krakow (Poland). Faculty of Physics and Applied Computer Science; Collaboration: ZEUS Collaboration; and others

    2014-05-15

    The production of beauty and charm quarks in ep interactions has been studied with the ZEUS detector at HERA for exchanged four-momentum squared 5beauty and charm content in events with at least one jet have been extracted using the invariant mass of charged tracks associated with secondary vertices and the decay-length significance of these vertices. Differential cross sections as a function of Q{sup 2}, Bjorken x, jet transverse energy and pseudorapidity were measured and compared with next-to-leading-order QCD calculations. The beauty and charm contributions to the proton structure functions were extracted from the double-differential cross section as a function of x and Q{sup 2}. The running beauty-quark mass, m{sub b} at the scale m{sub b}, was determined from a QCD fit at next-to-leading order to HERA data for the first time and found to be m{sub b}(m{sub b})=4.07±0.14(fit){sup +0.01}{sub -0.07} (mod.){sup +0.05}{sub -0.00}(param.){sup +0.08}{sub -0.05}(theo) GeV.

  10. Measurement of beauty and charm production in deep inelastic scattering at HERA and measurement of the beauty-quark mass

    CERN Document Server

    Abramowicz, H; Adamczyk, L.; Adamus, M.; Aggarwal, R.; Antonelli, S.; Arslan, O.; Aushev, V.; Aushev, Y.; Bachynska, O.; Barakbaev, A.N.; Bartosik, N.; Behnke, O.; Behr, J.; Behrens, U.; Bertolin, A.; Bhadra, S.; Bloch, I.; Bokhonov, V.; Boos, E.G.; Borras, K.; Brock, I.; Brugnera, R.; Bruni, A.; Brzozowska, B.; Bussey, P.J.; Caldwell, A.; Capua, M.; Catterall, C.D.; Chwastowski, J.; Ciborowski, J.; Ciesielski, R.; Cooper-Sarkar, A.M.; Corradi, M.; Corriveau, F.; D'Agostini, G.; Dementiev, R.K.; Devenish, R.C.E.; Dolinska, G.; Drugakov, V.; Dusini, S.; Ferrando, J.; Figiel, J.; Foster, B.; Gach, G.; Garfagnini, A.; Geiser, A.; Gizhko, A.; Gladilin, L.K.; Gogota, O.; Golubkov, Yu. A.; Grebenyuk, J.; Gregor, I.; Grzelak, G.; Gueta, O.; Guzik, M.; Hain, W.; Hartner, G.; Hochman, D.; Hori, R.; Ibrahim, Z.A.; Iga, Y.; Ishitsuka, M.; Iudin, A.; Januschek, F.; Kadenko, I.; Kananov, S.; Kanno, T.; Karshon, U.; Kaur, M.; Kaur, P.; Khein, L.A.; Kisielewska, D.; Klanner, R.; Klein, U.; Kondrashova, N.; Kononenko, O.; Korol, Ie.; Korzhavina, I.A.; Kotanski, A.; Kotz, U.; Kovalchuk, N.; Kowalski, H.; Kuprash, O.; Kuze, M.; Levchenko, B.B.; Levy, A.; Libov, V.; Limentani, S.; Lisovyi, M.; Lobodzinska, E.; Lohmann, W.; Lohr, B.; Lohrmann, E.; Longhin, A.; Lontkovskyi, D.; Lukina, O.Yu.; Maeda, J.; Makarenko, I.; Malka, J.; Martin, J.F.; Mergelmeyer, S.; Idris, F.Mohamad; Mujkic, K.; Myronenko, V.; Nagano, K.; Nigro, A.; Nobe, T.; Notz, D.; Nowak, R.J.; Olkiewicz, K.; Onishchuk, Yu.; Paul, E.; Perlanski, W.; Perrey, H.; Pokrovskiy, N.S.; Proskuryakov, A.S.; Przybycien, M.; Raval, A.; Roloff, P.; Rubinsky, I.; Ruspa, M.; Samojlov, V.; Saxon, D.H.; Schioppa, M.; Schmidke, W.B.; Schneekloth, U.; Schorner-Sadenius, T.; Schwartz, J.; Shcheglova, L.M.; Shehzadi, R.; Shevchenko, R.; Shkola, O.; Singh, I.; Skillicorn, I.O.; Slominski, W.; Sola, V.; Solano, A.; Spiridonov, A.; Stanco, L.; Stefaniuk, N.; Stern, A.; Stewart, T.P.; Stopa, P.; Sztuk-Dambietz, J.; Szuba, D.; Szuba, J.; Tassi, E.; Temiraliev, T.; Tokushuku, K.; Tomaszewska, J.; Trofymov, A.; Trusov, V.; Tsurugai, T.; Turcato, M.; Turkot, O.; Tymieniecka, T.; Verbytskyi, A.; Viazlo, O.; Walczak, R.; Wan Abdullah, W.A.T.; Wichmann, K.; Wing, M.; Wolf, G.; Yamada, S.; Yamazaki, Y.; Zakharchuk, N.; Zarnecki, A.F.; Zawiejski, L.; Zenaiev, O.; Zhautykov, B.O.; Zhmak, N.; Zotkin, D.S.

    2014-01-01

    The production of beauty and charm quarks in ep interactions has been studied with the ZEUS detector at HERA for exchanged four-momentum squared 5 < Q^2 < 1000 GeV^2 using an integrated luminosity of 354 pb^{-1}. The beauty and charm content in events with at least one jet have been extracted using the invariant mass of charged tracks associated with secondary vertices and the decay-length significance of these vertices. Differential cross sections as a function of Q^2, Bjorken x, jet transverse energy and pseudorapidity were measured and compared with next-to-leading-order QCD calculations. The beauty and charm contributions to the proton structure functions were extracted from the double-differential cross section as a function of x and Q^2. The running beauty-quark mass, m_b at the scale m_b, was determined from a QCD fit at next-to-leading order to HERA data for the first time and found to be 4.07 \\pm 0.14 (fit} ^{+0.01}_{-0.07} (mod.) ^{+0.05}_{-0.00} (param.) ^{+0.08}_{-0.05} (theo) GeV.

  11. Measurement of beauty and charm production in deep inelastic scattering at HERA and measurement of the beauty-quark mass

    International Nuclear Information System (INIS)

    The production of beauty and charm quarks in ep interactions has been studied with the ZEUS detector at HERA for exchanged four-momentum squared 522 using an integrated luminosity of 354 pb-1. The beauty and charm content in events with at least one jet have been extracted using the invariant mass of charged tracks associated with secondary vertices and the decay-length significance of these vertices. Differential cross sections as a function of Q2, Bjorken x, jet transverse energy and pseudorapidity were measured and compared with next-to-leading-order QCD calculations. The beauty and charm contributions to the proton structure functions were extracted from the double-differential cross section as a function of x and Q2. The running beauty-quark mass, mb at the scale mb, was determined from a QCD fit at next-to-leading order to HERA data for the first time and found to be mb(mb)=4.07±0.14(fit)+0.01-0.07 (mod.)+0.05-0.00(param.)+0.08-0.05(theo) GeV.

  12. Measurement of beauty and charm production in deep inelastic scattering at HERA and measurement of the beauty-quark mass

    Science.gov (United States)

    Abramowicz, H.; Abt, I.; Adamczyk, L.; Adamus, M.; Aggarwal, R.; Antonelli, S.; Arslan, O.; Aushev, V.; Aushev, Y.; Bachynska, O.; Barakbaev, A. N.; Bartosik, N.; Behnke, O.; Behr, J.; Behrens, U.; Bertolin, A.; Bhadra, S.; Bloch, I.; Bokhonov, V.; Boos, E. G.; Borras, K.; Brock, I.; Brugnera, R.; Bruni, A.; Brzozowska, B.; Bussey, P. J.; Caldwell, A.; Capua, M.; Catterall, C. D.; Chwastowski, J.; Ciborowski, J.; Ciesielski, R.; Cooper-Sarkar, A. M.; Corradi, M.; Corriveau, F.; D'Agostini, G.; Dementiev, R. K.; Devenish, R. C. E.; Dolinska, G.; Drugakov, V.; Dusini, S.; Ferrando, J.; Figiel, J.; Foster, B.; Gach, G.; Garfagnini, A.; Geiser, A.; Gizhko, A.; Gladilin, L. K.; Gogota, O.; Golubkov, Yu. A.; Grebenyuk, J.; Gregor, I.; Grzelak, G.; Gueta, O.; Guzik, M.; Hain, W.; Hartner, G.; Hochman, D.; Hori, R.; Ibrahim, Z. A.; Iga, Y.; Ishitsuka, M.; Iudin, A.; Januschek, F.; Kadenko, I.; Kananov, S.; Kanno, T.; Karshon, U.; Kaur, M.; Kaur, P.; Khein, L. A.; Kisielewska, D.; Klanner, R.; Klein, U.; Kondrashova, N.; Kononenko, O.; Korol, Ie.; Korzhavina, I. A.; Kotanski, A.; Kötz, U.; Kovalchuk, N.; Kowalski, H.; Kuprash, O.; Kuze, M.; Levchenko, B. B.; Levy, A.; Libov, V.; Limentani, S.; Lisovyi, M.; Lobodzinska, E.; Lohmann, W.; Löhr, B.; Lohrmann, E.; Longhin, A.; Lontkovskyi, D.; Lukina, O. Yu.; Maeda, J.; Makarenko, I.; Malka, J.; Martin, J. F.; Mergelmeyer, S.; Mohamad Idris, F.; Mujkic, K.; Myronenko, V.; Nagano, K.; Nigro, A.; Nobe, T.; Notz, D.; Nowak, R. J.; Olkiewicz, K.; Onishchuk, Yu.; Paul, E.; Perlanski, W.; Perrey, H.; Pokrovskiy, N. S.; Proskuryakov, A. S.; Przybycien, M.; Raval, A.; Roloff, P.; Rubinsky, I.; Ruspa, M.; Samojlov, V.; Saxon, D. H.; Schioppa, M.; Schmidke, W. B.; Schneekloth, U.; Schörner-Sadenius, T.; Schwartz, J.; Shcheglova, L. M.; Shehzadi, R.; Shevchenko, R.; Shkola, O.; Singh, I.; Skillicorn, I. O.; Slominski, W.; Sola, V.; Solano, A.; Spiridonov, A.; Stanco, L.; Stefaniuk, N.; Stern, A.; Stewart, T. P.; Stopa, P.; Sztuk-Dambietz, J.; Szuba, D.; Szuba, J.; Tassi, E.; Temiraliev, T.; Tokushuku, K.; Tomaszewska, J.; Trofymov, A.; Trusov, V.; Tsurugai, T.; Turcato, M.; Turkot, O.; Tymieniecka, T.; Verbytskyi, A.; Viazlo, O.; Walczak, R.; Wan Abdullah, W. A. T.; Wichmann, K.; Wing, M.; Wolf, G.; Yamada, S.; Yamazaki, Y.; Zakharchuk, N.; Żarnecki, A. F.; Zawiejski, L.; Zenaiev, O.; Zhautykov, B. O.; Zhmak, N.; Zotkin, D. S.

    2014-10-01

    The production of beauty and charm quarks in ep interactions has been studied with the ZEUS detector at HERA for exchanged four-momentum squared 5 < Q 2 < 1000 GeV2 using an integrated luminosity of 354 pb-1. The beauty and charm content in events with at least one jet have been extracted using the invariant mass of charged tracks associated with secondary vertices and the decay-length significance of these vertices. Differential cross sections as a function of Q 2, Bjorken x, jet trans- verse energy and pseudorapidity were measured and compared with next-to-leading-order QCD calculations. The beauty and charm contributions to the proton structure functions were extracted from the double-differential cross section as a function of x and Q 2. The running beauty-quark mass, m b at the scale m b , was determined from a QCD fit at next-to-leading order to HERA data for the first time and found to be m b ( m b ) = 4.07 ± 0.14 (fit){-/0.07 + 0.01}(mod.){-/0.00 + 0.05}(param.){-/0.05 + 0.08}(theo.) GeV.

  13. Hidden-Beauty Charged Tetraquarks and Heavy Quark Spin Conservation

    CERN Document Server

    Ali, A; Polosa, A D; Riquer, V

    2014-01-01

    Assuming the dominance of the spin-spin interaction in a diquark, we point out that the mass differences in the beauty sector M(Z_b') - M(Z_b) scale with quark masses as expected in QCD, with respect to the corresponding mass difference M(Z_c') - M(Z_c). Notably, we show that the decays Upsilon(10890) --> (h_b(1P), h_b(2P)) pi pi are compatible with heavy-quark spin conservation once the contributions of Z_b,Z_b' intermediate states are taken into account, Upsilon(10890) being either a Upsilon(5S) or the beauty analog of Y_c(4260).

  14. Penta-quark States with Strangeness, Hidden Charm and Beauty

    CERN Document Server

    Wu, Jia-Jun

    2015-01-01

    The classical quenched quark models with three constituent quarks provide a good description for the baryon spatial ground states, but fail to reproduce the spectrum of baryon excited states. More and more evidences suggest that unquenched effects with multi-quark dynamics are necessary ingredients to solve the problem. Several new hyperon resonances reported recently could fit in the picture of penta-quark states. Based on this picture, some new hyperon excited states were predicted to exist; meanwhile with extension from strangeness to charm and beauty, super-heavy narrow $N^*$ and $\\Lambda^*$ resonances with hidden charm or beauty were predicted to be around 4.3 and 11 GeV, respectively. Recently, two of such $N^*$ with hidden charm might have been observed by the LHCb experiment. More of those states are expected to be observed in near future. This opens a new window in order to study hadronic dynamics for the multi-quark states.

  15. Perceived beauty of random texture patterns: A preference for complexity.

    Science.gov (United States)

    Friedenberg, Jay; Liby, Bruce

    2016-07-01

    We report two experiments on the perceived aesthetic quality of random density texture patterns. In each experiment a square grid was filled with a progressively larger number of elements. Grid size in Experiment 1 was 10×10 with elements added to create a variety of textures ranging from 10%-100% fill levels. Participants rated the beauty of the patterns. Average judgments across all observers showed an inverted U-shaped function that peaked near middle densities. In Experiment 2 grid size was increased to 15×15 to see if observers preferred patterns with a fixed density or a fixed number of elements. The results of the second experiment were nearly identical to that of the first showing a preference for density over fixed element number. Ratings in both studies correlated positively with a GIF compression metric of complexity and with edge length. Within the range of stimuli used, observers judge more complex patterns to be more beautiful.

  16. Physics analysis tools for beauty physics in ATLAS

    Energy Technology Data Exchange (ETDEWEB)

    Anastopoulos, C [Physics Department, Aristotle University Of Thessaloniki (Greece); Bouhova-Thacker, E; Catmore, J; Mora, L de [Department of Physics, Lancaster University (United Kingdom); Dallison, S [Particle Physics Department, CCLRC Rutherford Appleton Laboratory (United Kingdom); Derue, F [LPNHE, IN2P3 - CNRS - Universites Paris VI et Paris VII (France); Epp, B; Jussel, P [Institute for Astro- and Particle Physics, University of Innsbruck (Austria); Kaczmarska, A [Institute of Nuclear Physics, Polish Academy of Sciences (Poland); Radziewski, H v; Stahl, T [Department of Physics, University of Siegen (Germany); Reznicek, P [IPNP, Faculty of Mathematics and Physics, Charles University in Prague (Czech Republic)], E-mail: pavel.reznicek@cern.ch

    2008-07-15

    The Large Hadron Collider experiments will search for physics phenomena beyond the Standard Model. Highly sensitive tests of beauty hadrons will represent an alternative approach to this research. The analysis of complex decay chains of the beauty hadrons have to efficiently extract the detector tracks made by these reactions and reject other events in order to make sufficiently precise measurement. This places severe demands on the software used to analyze the B-physics data. The ATLAS B-physics group has written a series of tools and algorithms for performing these tasks, to be run within the ATLAS offline software framework Athena. This paper describes this analysis suite, paying particular attention to mechanisms for handling combinatorics, interfaces to secondary vertex fitting packages, B-flavor tagging tools and finally Monte Carlo true information association to pursue simulation data in process of the software validations which is an important part of the development of the physics analysis tools.

  17. Perceived beauty of random texture patterns: A preference for complexity.

    Science.gov (United States)

    Friedenberg, Jay; Liby, Bruce

    2016-07-01

    We report two experiments on the perceived aesthetic quality of random density texture patterns. In each experiment a square grid was filled with a progressively larger number of elements. Grid size in Experiment 1 was 10×10 with elements added to create a variety of textures ranging from 10%-100% fill levels. Participants rated the beauty of the patterns. Average judgments across all observers showed an inverted U-shaped function that peaked near middle densities. In Experiment 2 grid size was increased to 15×15 to see if observers preferred patterns with a fixed density or a fixed number of elements. The results of the second experiment were nearly identical to that of the first showing a preference for density over fixed element number. Ratings in both studies correlated positively with a GIF compression metric of complexity and with edge length. Within the range of stimuli used, observers judge more complex patterns to be more beautiful. PMID:27155800

  18. A study of beauty and charm muoproduction at the SPS

    International Nuclear Information System (INIS)

    We propose an experiment to study beauty and charm muoproduction via semi-leptonic decays into multi-muon final states. The apparatus for the experiment is based on the EMC Forward Spectrometer (NA2) with a factor proportional 500 increase in luminosity. The measurements proposed include the study of upsilon and B-anti B production and will provide for a much improved experimental limit on the amount of D0 - anti D0 mixing. From a comparison of the charm decays into 2 and 3-muon final states it is proposed to make a direct measurement of the intrinsic charm content of the nucleon. We also comment on possible studies of rare charm and beauty decays into multi-muon final states. (orig.)

  19. Hierarchy of lifetimes of charmed and beautiful hadrons

    International Nuclear Information System (INIS)

    Pre-asymptotic corrections to total hadronic widths of weak decays of charmed and beautiful hadrons are considered. The main emphasis is put on effects due to the spectator quark. The so called hybrid logarithms emerging from the domain of momenta R-2 2 Q2 (R is the hadronic size, mQ is the heavy quark mass) are taken into account, a new element of the analysis. For chamed hadrons the pre-asymptotic corrections are of order unity, and the corresponding estimates of non leptonic widths are of semiquantitative character. The hierarchy of hadronic widths for D, F mesons and Λc, Ξc(A), Ωc baryons is establish. The lifetime of Ωc0 turns out to be the smallest. The difference in lifetimes of beautiful hadrons is predicted to be definitely less than a few percent

  20. Beauty and conservation: a metaphysical, pedagogical and ecclesiastical perspective

    Directory of Open Access Journals (Sweden)

    Mauro Mantovani

    2014-02-01

    Full Text Available After considering the notions of technology, art and culture, this essay presents a brief study on the metaphysical concept of beauty referring particularly to the thought of Thomas Aquinas and then proposing its application in an anthropological-pedagogical sphere. Focus then moves onto the philosophical concept of “conservation”. In this way the paper intends to show how Christian thought has necessarily deepened – in the light of the fundamental notions that belong to it – both the meaning of beauty, the artistic one included, and the concept of conservation and how these perspectives can represent in some way an interesting contribution for those who work in the field of conservation sciences or in the field of the planning and promotion of artistic and cultural events, especially if these events relate to religious heritage.

  1. The beautiful invisible creativity, imagination, and theoretical physics

    CERN Document Server

    Vignale, Giovanni

    2011-01-01

    Challenging the image of theoretical physics as a dry discipline, The Beautiful Invisible shows that this highly abstract science is in fact teeming with beautiful concepts, and the task of imagining them demands profound creativity, just as creative as the work of poets or magical realist novelists such as Borges and Musil. "A good scientific theory is like a symbolic tale, an allegory of reality," writes Giovanni Vignale, as he uncovers the unexpected links between theoretical physics and artistic creativity. In engaging and at times poetic prose, and with ample quotations from many of the writers he admires, Vignale presents his own unorthodox accounts of fundamental theoretical concepts such as Newtonian mechanics, superconductivity, and Einstein's theory of relativity, illuminating their profound implications. Throughout, the author treats readers to glimpses of physics as "exercised in the still night, when only the moon rages." Indeed, as we delve behind now-familiar concepts such as "electron spin" an...

  2. Penta-Quark States with Strangeness, Hidden Charm and Beauty

    Science.gov (United States)

    Wu, Jia-Jun; Zou, Bing-Song

    The classical quenched quark models with three constituent quarks provide a good description for the baryon spatial ground states, but fail to reproduce the spectrum of baryon excited states. More and more evidences suggest that unquenched effects with multi-quark dynamics are necessary ingredients to solve the problem. Several new hyperon resonances reported recently could fit in the picture of penta-quark states. Based on this picture, some new hyperon excited states were predicted to exist; meanwhile with extension from strangeness to charm and beauty, super-heavy narrow N* and Λ* resonances with hidden charm or beauty were predicted to be around 4.3 and 11 GeV, respectively. Recently, two of such N* with hidden charm might have been observed by the LHCb experiment. More of those states are expected to be observed in near future. This opens a new window in order to study hadronic dynamics for the multi-quark states.

  3. Enhancer trapping in zebrafish using the Sleeping Beauty transposon

    OpenAIRE

    Welle Zachary; Hermanson Spencer B; Sivasubbu Sridhar; Davidson Ann E; Balciunas Darius; Ekker Stephen C

    2004-01-01

    Abstract Background Among functional elements of a metazoan gene, enhancers are particularly difficult to find and annotate. Pioneering experiments in Drosophila have demonstrated the value of enhancer "trapping" using an invertebrate to address this functional genomics problem. Results We modulated a Sleeping Beauty transposon-based transgenesis cassette to establish an enhancer trapping technique for use in a vertebrate model system, zebrafish Danio rerio. We established 9 lines of zebrafis...

  4. Beauty and charm production from Fermilab experiment 789

    Energy Technology Data Exchange (ETDEWEB)

    Jansen, D.M.; Boissevain, J.; Carey, T.A.; Jeppesen, R.G.; Kapustinsky, J.S.; Lane, D.W.; Leitch, M.J.; Lillberg, J.W.; McGaughey, P.L.; Moss, J.M.; Peng, J.C. [Los Alamos National Lab., NM (United States); Brown, G.; Isenhower, L.D.; Keyser, J.; Sadler, M.E.; Schnathorst, R.; Schwindt, R. [Abilene Christian Univ., TX (United States); Gidal, G.; Ho, P.M.; Kowitt, M.S.I.; Luk, K.B.; Pripstein, D. [Lawrence Berkeley Lab., CA (United States); Lederman, L.M.; Schub, M.H. [Chicago Univ., IL (United States); Brown, C.N.; Cooper, W.E.; Glass, H.D.; Gounder, K.N.; Mishra, C.S. [Fermi National Accelerator Lab., Batavia, IL (United States); Kaplan, D.M.; Luebke, W.R.; Martin, V.M.; Preston, R.S.; Sa, J.; Tanikella, V. [Northern Illinois Univ., De Kalb, IL (United States); Childers, R.; Darden, C.W.; Snodgrass, D.; Wilson, J.R. [South Carolina Univ., Columbia, SC (United States); Chen, Y.C. [Academia Sinica, Taipei (Taiwan, Province of China). Inst. of Physics]|[National Cheng Kung Univ., Tainan (Taiwan, Province of China). Inst. of Physics; Kiang, G.C.; Teng, P.K. [Academia Sinica, Taipei (Taiwan, Province of China). Inst. of Physics

    1993-06-01

    Experiment 789 is a fixed-target experiment at Fermilab designed to study low-multiplicity decays of charm and beauty. During the 1991 run. E789 collected {approx} 10{sup 9} events using an 800 GeV proton beam incident upon gold and beryllium targets. Analyses of these data include searches for b {yields} J/{psi}+{Chi} decays and {Alpha}- dependence measurements of neutral D meson production. Preliminary results from the 1991 run are presented in this paper.

  5. Lifetime unbiased beauty and charm triggers at LHCb

    CERN Document Server

    Kenzie, Matthew William

    2016-01-01

    This note describes the use of lifetime unbiased triggers in LHCb's High Level Trigger system, implemented during Run 2 of LHC data collection. This is the first time such a strategy has been employed to exclusively trigger on signal candidates in a lifetime unbiased way at a hadron collider. It provides samples of charm and beauty hadrons whose lifetime acceptance due to the trigger requirements is uniform. Consequently, these triggers are suitable for time-dependent measurements and calibration purposes.

  6. Hadron spectroscopy from strangeness to charm and beauty

    Energy Technology Data Exchange (ETDEWEB)

    Zou, B.S., E-mail: zoubs@ihep.ac.cn [State Key Laboratory of Theoretical Physics, Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 100190 (China); Institute of High Energy Physics and Theoretical Physics Center for Science Facilities, Chinese Academy of Sciences, Beijing 100049 (China)

    2013-09-20

    Quarks of different flavors have different masses, which will cause breaking of flavor symmetries of QCD. Flavor symmetries and their breaking in hadron spectroscopy play important role for understanding the internal structures of hadrons. Hadron spectroscopy with strangeness reveals the importance of unquenched quark dynamics. Systematic study of hadron spectroscopy with strange, charm and beauty quarks would be very revealing and essential for understanding the internal structure of hadrons and its underlying quark dynamics.

  7. The beauty of knots at the molecular level.

    Science.gov (United States)

    Sauvage, Jean-Pierre; Amabilino, David B

    2012-01-01

    What makes a given object look beautiful to the observer, be it in the macroscopic world or at the molecular level? This very general question will be briefly addressed at the beginning of this essay, in relation to contemporary molecular chemistry and biology, leading to the general statement that, most of the time, beauty is tightly connected to function as well as to the cultural background of the observer. The main topic of the present article will be that of topologically non-trivial molecules or molecular ensembles and the fascination that such species have exerted on molecular or solid state chemists. Molecules with a graph identical to Kuratowski's K₅ or K₃,₃ graphs are indeed highly attractive from an aesthetical viewpoint, but perhaps even more fascinating and beautiful are molecular knots. A general discussion will be devoted to these compounds, which are still considered as exotic species because of the very limited number of efficient synthetic strategies leading to their preparation. Particularly efficient are templated approaches based either on transition metals such as copper(I) or on organic groups able to form hydrogen bonds or acceptor-donor stacks. A particularly noteworthy property of knots, and in particular of the trefoil knot, is their topological chirality. The isolation of both enantiomers of the trefoil knot (3₁) could be achieved and showed that such species have fascinating chiroptical properties. Finally, various routes to more complex and beautiful knots than the trefoil knot, which is the simplest non-trivial knot, will be discussed in line with the remarkable ability of transition metals to gather and orient in a very precise fashion several organic components in their coordination spheres, thus leading to synthetic precursors displaying geometries which are perfectly well adapted to the preparation of the desired knots or links.

  8. BEAUTY, HEALTH AND WELL-BEING WITH COSMETOTEXTILES

    OpenAIRE

    CRETU Viorica

    2014-01-01

    The concept of cosmetotextiles, as another aspect of new beauty and health marques a growing success. This hybrid fabric, is definite as a textile article that contains a substance that is release sustainable on the human body skin pointed to perfume, change of appearance, maintenance in good condition, protection, or correction of body odors. Cosmetotextiles are created by microencapsulating different substances for body care or health, that are gradually transfer to the skin, by movement...

  9. Consensus on Changing Trends, Attitudes, and Concepts of Asian Beauty

    OpenAIRE

    Liew, Steven; Wu, Woffles T. L.; Chan, Henry H.; Ho, Wilson W. S.; Kim, Hee-Jin; Goodman, Greg J; Peng, Peter H. L.; Rogers, John D.

    2015-01-01

    Background Asians increasingly seek non-surgical facial esthetic treatments, especially at younger ages. Published recommendations and clinical evidence mostly reference Western populations, but Asians differ from them in terms of attitudes to beauty, structural facial anatomy, and signs and rates of aging. A thorough knowledge of the key esthetic concerns and requirements for the Asian face is required to strategize appropriate facial esthetic treatments with botulinum toxin and hyaluronic a...

  10. Beautiful Teams Inspiring and Cautionary Tales from Veteran Team Leaders

    CERN Document Server

    Stellman, Andrew

    2009-01-01

    What's it like to work on a great software development team facing an impossible problem? How do you build an effective team? Beautiful Teams takes you behind the scenes with some of the most interesting teams in software engineering history. You'll learn from veteran team leaders' successes and failures, told through a series of engaging personal stories -- and interviews -- by leading programmers, architects, project managers, and thought leaders.

  11. Feminist guilt or the ambivalency of feminism towards beauty practices

    OpenAIRE

    Otorepec, Klara

    2015-01-01

    The purpose of this thesis is to research different factors that help shape and form the concept of feminist guilt. This is how I name the discomfort that occurs as a response to difficulties in exercising feminist principles in daily life in relation to (non)practising beauty practices or as a dichotomy between feminist ideology and patriarchal social order. The theoretical focus explores how the pressure of normative femininity as a Foucauldian disciplinary project of contemporary society, ...

  12. A study of strange-, charmed, and beauty nuclei

    International Nuclear Information System (INIS)

    An analyses is made of the bound states of nuclei in the strange-, charm-, and beauty sector using a spin-dependent Gaussian two-body interaction in the microscopic formalism. Coulomb corrections are also included for the charmed nuclei. Our simple model is in reasonable agreement with other existing theoretical and experimental results and it predicts many new bound states. (author). 21 refs, 2 figs, 10 tabs

  13. Beauty and charm production from Fermilab experiment 789

    International Nuclear Information System (INIS)

    Experiment 789 is a fixed-target experiment at Fermilab designed to study low-multiplicity decays of charm and beauty. During the 1991 run. E789 collected ∼ 109 events using an 800 GeV proton beam incident upon gold and beryllium targets. Analyses of these data include searches for b → J/ψ+Χ decays and Α- dependence measurements of neutral D meson production. Preliminary results from the 1991 run are presented in this paper

  14. Hadron spectroscopy from strangeness to charm and beauty

    International Nuclear Information System (INIS)

    Quarks of different flavors have different masses, which will cause breaking of flavor symmetries of QCD. Flavor symmetries and their breaking in hadron spectroscopy play important role for understanding the internal structures of hadrons. Hadron spectroscopy with strangeness reveals the importance of unquenched quark dynamics. Systematic study of hadron spectroscopy with strange, charm and beauty quarks would be very revealing and essential for understanding the internal structure of hadrons and its underlying quark dynamics

  15. BURBERRY BEAUTY2012秋冬妆容

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    BURBERRY BEAUTY2012秋冬系列以大热裸妆为主,作为全球奢华底妆专家,不但为底妆家族推出了众所期待的新成员BURBERRY明亮丝滑遮瑕笔,同时为限部及唇部产品加入全新色系。

  16. Recurrent encephalopathy? No I’m a sleeping beauty!

    OpenAIRE

    Mehtab Iqbal; Manish Prasad; Christopher Ritey

    2014-01-01

    To describe the clinical presentation of ′Kleine-Levin (sleeping beauty) syndrome′ in a child, who presented with recurrent episodes consistent with encephalopathy, associated with excessive sleepiness, cognitive and behavioural disturbance and hyper sexuality. 14 years old boy presented acutely with excessive tiredness, sleeping excessively, abnormal behaviour and hypersexuality following a viral throat infection. On examination he was sleepy but easily arousable. His GCS (15/15) and rest of...

  17. Construction of compactly supported orthonormal wavelets with beautiful structure

    Institute of Scientific and Technical Information of China (English)

    PENG Lizhong; WANG Yongge

    2004-01-01

    In this paper, a new method of constructing symmetric (antisymmetric) scaling and wavelet filters is introduced, and we get a new type of wavelet system that has very beautiful structure. Using this kind of wavelet system, we can achieve filters with the properties: rational, symmetric or antisymmetric, the lengths of the filters are shorter and the corresponding functions have higher smoothness, so they have good prospect in applications.

  18. Thailand, A beauty hub for everyone? : Internationalizing Thai Aesthetic Surgery

    OpenAIRE

    Sinhaneti, Kantara; Pullawan, Jitmanee

    2008-01-01

    Introduction: Aesthetic surgery becomes another option of beauty. Interested Patients seeking for choices offered outside their homeland for more benefits. Thailand maybe one of those choices people is now interested in. Thai aesthetic industry may prove to be one of the most wanted destinations because of its expertise and relatively low cost with impressive service. Problem: “How should Thailand improve its Aesthetic service attractiveness to drive its potential to the level of internationa...

  19. The "Beautiful" pain: cosmetic surgery and the embodiment of pain

    OpenAIRE

    Alexias, George; Dilaki, Georgija; Tsekeris, Charalambos

    2012-01-01

    This article focuses on women undergoing plastic surgery operations, highlighting their particular attitude toward pain, which is caused by the desperate pursuit of beauty. Extracting data from semi-structured interviews, it is shown how pain is defied, eliminated or even denied by individuals undergoing cosmetic surgery. Since cosmetic procedures are carried out for aesthetic reasons, people disconnect this process from any negative emotion and ignore pain and trauma yielded from surgical op...

  20. The Beauty Contest and Short-Term Trading

    OpenAIRE

    Giovanni Cespa; Xavier Vives

    2014-01-01

    Short-termism need not breed informational price inefficiency even when generating Beauty Contests. We demonstrate this claim in a two-period market with persistent liquidity trading and risk-averse, privately informed, short-term investors and find that prices reect average expectations about fundamentals and liquidity trading. Informed investors engage in "retrospective" learning to reassess inferences (about fundamentals) made during the trading game's early stages. This behavior introduce...

  1. Spectroscopy of onia and hadrons with open beauty in ATLAS

    CERN Document Server

    Henderson, RCW; The ATLAS collaboration

    2015-01-01

    Results published by the ATLAS experiment at the LHC are presented. The ATLAS discovery of the $\\chi_b(3P)$ onia state is recalled and report the new observation of an excited open beauty hadronic state, a $B_c^{\\pm}$ meson with mass $6842 \\pm 4(stat) \\pm 5(syst)$ MeV consistent with expectations for the $B_c^{\\pm}(2S)$.

  2. Measurement of open beauty production in photoproduction at HERA

    CERN Document Server

    Breitweg, J; Derrick, Malcolm; Krakauer, D A; Magill, S; Musgrave, B; Pellegrino, A; Repond, J; Stanek, R; Yoshida, R; Mattingly, M C K; Antonioli, P; Bari, G; Basile, M; Bellagamba, L; Boscherini, D; Bruni, A; Bruni, G; Cara Romeo, G; Cifarelli, Luisa; Cindolo, F; Contin, A; Corradi, M; De Pasquale, S; Giusti, P; Iacobucci, G; Levi, G; Margotti, A; Massam, Thomas; Nania, R; Palmonari, F; Pesci, A; Sartorelli, G; Zichichi, A; Aghuzumtsyan, G; Amelung, C; Brock, I; Coboken, K; Goers, S; Hartmann, H; Heinloth, K; Hilger, E; Irrgang, P; Jakob, H P; Kappes, A; Katz, U F; Kerger, R; Kind, O; Paul, E; Rautenberg, J; Schnurbusch, H; Stifutkin, A; Tandler, J; Voss, K C; Weber, A; Wieber, H; Bailey, D S; Barret, O; Brook, N H; Cole, J E; Foster, B; Heath, G P; Heath, H F; Robins, S A; Rodrigues, E; Scott, J; Tapper, R J; Capua, M; Mastroberardino, A; Schioppa, M; Susinno, G; Jeoung, H Y; Kim, J Y; Lee, J H; Lim, I T; Ma, K J; Pac, M Y; Caldwell, A; Liu, W; Liu, X; Mellado, B; Paganis, S; Sampson, S; Schmidke, W B; Sciulli, F; Chwastowski, J; Eskreys, Andrzej; Figiel, J; Klimek, K H; Olkiewicz, K; Piotrzkowski, K; Przybycien, M B; Stopa, P; Zawiejski, L; Bednarek, B; Jelen, K; Kisielewska, D; Kowal, A M; Kowalski, T; Rulikowska-Zarebska, E; Suszycki, L; Szuba, D; Bauerdick, L A T; Behrens, U; Bienlein, J K; Borras, K; Chiochia, V; Crittenden, James Arthur; Dannheim, D; Desler, K; Drews, G; Fox-Murphy, A; Fricke, U; Göbel, F; Göttlicher, P; Graciani, R; Haas, T; Hain, W; Hartner, G F; Hebbel, K; Hillert, S; Koch, W; Kötz, U; Kowalski, H; Labes, H; Löhr, B; Mankel, R; Martens, J; Martínez, M; Milite, M; Moritz, M; Notz, D; Petrucci, M C; Polini, A; Rohde, M; Savin, A A; Schneekloth, U; Selonke, F; Sievers, M; Stonjek, S; Wolf, G; Wollmer, U; Youngman, C; Zeuner, W; Coldewey, C; López-Duran-Viani, A; Meyer, A; Schlenstedt, S; Straub, P B; Barbagli, G; Gallo, E; Parenti, A; Pelfer, P G; Bamberger, Andreas; Benen, A; Coppola, N; Eisenhardt, S; Markun, P; Raach, H; Wölfle, S; Bussey, Peter J; Bell, M; Doyle, A T; Glasman, C; Lee, S W; Lupi, A; MacDonald, N; McCance, G J; Saxon, D H; Sinclair, L E; Skillicorn, Ian O; Waugh, R; Bodmann, B; Gendner, N; Holm, U; Salehi, H; Wick, K; Yildirim, A; Carli, T; Garfagnini, A; Geiser, A; Gialas, I; Kcira, D; Klanner, Robert; Lohrmann, E; Goncalo, R; Long, K R; Miller, D B; Tapper, A D; Walker, R; Cloth, P; Filges, D; Ishii, T; Kuze, M; Nagano, K; Tokushuku, K; Yamada, S; Yamazaki, Y; Boos, E G; Pokrovskiy, N S; Zhautykov, B O; Barakbaev, A N; Ahn, S H; Lee, S B; Park, S K; Lim, H; Son, D; Barreiro, F; García, G; González, O; Labarga, L; Del Peso, J; Redondo, I; Terron, J; Vázquez, M E; Barbi, M S; Corriveau, F; Padhi, S; Stairs, D G; Wing, M; Tsurugai, T; Antonov, A; Bashkirov, V; Danilov, M V; Dolgoshein, B A; Gladkov, D; Sosnovtsev, V V; Suchkov, S; Dementiev, R K; Ermolov, P F; Golubkov, Yu A; Katkov, I I; Khein, L A; Korotkova, N A; Korzhavina, I A; Kuzmin, V A; Lukina, O Yu; Proskuryakov, A S; Shcheglova, L M; Solomin, A N; Vlasov, N N; Zotkin, S A; Bokel, C; Botje, M; Brümmer, N; Engelen, J; Grijpink, S; Koffeman, E; Kooijman, P M; Schagen, S; Van Sighem, A; Tassi, E; Tiecke, H G; Tuning, N; Velthuis, J J; Vossebeld, Joost Herman; Wiggers, L; De Wolf, E; Bylsma, B; Durkin, L S; Gilmore, J; Ginsburg, C M; Kim, C L; Ling, T Y; Boogert, S; Cooper-Sarkar, A M; Devenish, R C E; Grosse-Knetter, J; Matsushita, T; Ruske, O; Sutton, M R; Walczak, R; Bertolin, A; Brugnera, R; Carlin, R; Dal Corso, F; Dusini, S; Limentani, S; Longhin, A; Posocco, M; Stanco, L; Turcato, M; Adamczyk, L; Iannotti, L; Oh, B Y; Okrasinski, J R; Saull, P R B; Toothacker, W S; Whitmore, J J; Iga, Y; D'Agostini, Giulio; Marini, G; Nigro, A; Cormack, C; Hart, J C; McCubbin, N A; Shah, T P; Epperson, D E; Heusch, C A; Sadrozinski, H F W; Seiden, A; Wichmann, R; Williams, D C; Park, I H; Pavel, N; Abramowicz, H; Dagan, S; Gabareen, A; Kananov, S; Kreisel, A; Levy, A; Abe, T; Fusayasu, T; Kohno, T; Umemori, K; Yamashita, T; Hamatsu, R; Hirose, T; Inuzuka, M; Kitamura, S; Matsuzawa, K; Nishimura, T; Arneodo, M; Cartiglia, N; Cirio, R; Costa, M; Ferrero, M I; Maselli, S; Monaco, V; Peroni, C; Ruspa, M; Sacchi, R; Solano, A; Staiano, A; Bailey, D C; Fagerstroem, C P; Galea, R; Koop, T; Levman, G M; Martin, J F; Mirea, A; Sabetfakhri, A; Butterworth, J M; Gwenlan, C; Hayes, M E; Heaphy, E A; Jones, T W; Lane, J B; West, B J; Ciborowski, J; Ciesielski, R; Grzelak, G; Nowak, R J; Pawlak, J M; Pawlak, R; Smalska, B; Tymieniecka, T; Wróblewski, A K; Zakrzewski, J A

    2001-01-01

    The production and semi-leptonic decay of heavy quarks have been studied in the photoproduction process $e^+p -> e^+ + {dijet} + e^- + X with the ZEUS detector at HERA using an integrated luminosity of 38.5 ${\\rm pb^{-1}}$. Events with photon-proton centre-of-mass energies, $W_{\\gamma p}$, between 134 and 269 GeV and a photon virtuality, Q^2, less than 1 ${\\rm GeV^2}$ were selected requiring at least two jets of transverse energy $E_T^{\\rm jet1(2)} >7(6)$ GeV and an electron in the final state. The electrons were identified by employing the ionisation energy loss measurement. The contribution of beauty quarks was determined using the transverse momentum of the electron relative to the axis of the closest jet, $p_T^{\\rm rel}$. The data, after background subtraction, were fit with a Monte Carlo simulation including beauty and charm decays. The measured beauty cross section was extrapolated to the parton level with the b quark restricted to the region of transverse momentum $p_T^{b} > p_T^{\\rm min} =$ 5 GeV and ...

  3. New Observations of beauty baryon decays at LHCb

    CERN Document Server

    Vitaly, Andreev

    2014-01-01

    This report describes the work I have done during my summer student association with the LHCb (Large Hadron Collider Beauty Experiment) collaboration at CERN from 30.06 till 26.09.2014. The project was performed in a team with two other summer students. In this report I concentrate on my contribution to the team work. In addition, one section is dedicated to the management framework called “scrum” which we used to collaborate as a team. The goal of my task was to analyze yet unobserved decays of the beauty Lambda-b-0 baryon. This is interesting since the CP violation still remains unobserved in baryons and beauty baryons are generally not well-known yet. LHCb is the first detector where these heavy baryons can be analyzed in detail. In addition these decays may play an important role in other processes and one can gain new insights into the strong interaction. The analysis presented here was performed on the full 2011-2012 LHC run data and includes several decays which are observed for the first time.

  4. Longing for Clouds - Does Beautiful Weather have to be Fine?

    Directory of Open Access Journals (Sweden)

    Mădălina Diaconu

    2016-01-01

    Full Text Available Any attempt to outline a meteorological aesthetics centered on so-called beautiful weather has to overcome several difficulties: In everyday life, the appreciation of the weather is mostly related to practical interests or reduced to the ideal of stereotypical fine weather that is conceived according to blue-sky thinking irrespective of climate diversity. Also, an aesthetics of fine weather seems, strictly speaking, to be impossible given that such weather conditions usually allow humans to focus on aspects other than weather, which contradicts the autotelic character of beauty. The unreflective equation of beautiful weather with moderately sunny weather and a cloudless sky also collides with the psychological need for variation: even living in a “paradisal” climate would be condemned to end in monotony. Finally, whereas fine weather is related in modern realistic literature to cosmic harmony and a universal natural order, contemporary literary examples show that in the age of the climate change, fine weather may be deceitful and its passive contemplation, irresponsible. This implies the necessity of a reflective aesthetic attitude on weather, as influenced by art, literature, and science, which discovers the poetics of bad weather and the wonder that underlies average weather conditions.

  5. Beauty and healing: examining sociocultural expectations of the embodied goddess.

    Science.gov (United States)

    Yeh, Jin-Tsann; Lin, Chyong-Ling

    2013-03-01

    Studies indicate mental health improvement can occur via religious communities offering social support and other resources. Many people from many cultures regard medicine as a supernatural or magical treatment that can somehow lead to a better state of living. In medical advertising, female role portrayal involves the blending of beauty, ritual and attractiveness in combination with the best product image. A Chinese saying suggests that, "A girl will doll herself up for him who loves her." Female role attraction is a very important ethical subject in gender issues. Moving forward in time, female role visualization and consumption in medical advertising reveal depictions that encouraged women to do some self-searching and find, or develop, inner strength. This study is designed to examine female role portrayals in a restricted patriarchal society. The results indicate that the ideology of motherhood is an accepted social orientation that the public readily identifies with. Results further indicate that beautification through medical products incorporates an emotional element of religious healing and that the objectification of beauty in the media reveals a possible neglect of women's internal beauty. PMID:21360223

  6. Measurement of open beauty production in photoproduction at HERA

    Science.gov (United States)

    ZEUS Collaboration; Breitweg, J.; et al.

    2001-01-01

    The production and semi-leptonic decay of heavy quarks have been studied in the photoproduction process e+p -> e+ + dijet + e- + X with the ZEUS detector at HERA using an integrated luminosity of 38.5 pb -1. Events with photon-proton centre-of-mass energies, Wγ p, between 134 and 269 GeV and a photon virtuality, Q2, less than 1 GeV 2 were selected requiring at least two jets of transverse energy ET jet1(2) >7(6) GeV and an electron in the final state. The electrons were identified by employing the ionisation energy loss measurement. The contribution of beauty quarks was determined using the transverse momentum of the electron relative to the axis of the closest jet, pT rel. The data, after background subtraction, were fit with a Monte Carlo simulation including beauty and charm decays. The measured beauty cross section was extrapolated to the parton level with the b quark restricted to the region of transverse momentum pT^b > pT^min = 5 GeV and pseudorapidity |η b| < 2. The extrapolated cross section is 1.6 +/- 0.4 (stat.)+0.3-0.5 (syst.) +0.2-0.4 (ext.) nb. The result is compared to a perturbative QCD calculation performed to next-to-leading order.

  7. Germline transgenesis in rabbits by pronuclear microinjection of Sleeping Beauty transposons.

    Science.gov (United States)

    Ivics, Zoltán; Hiripi, László; Hoffmann, Orsolya I; Mátés, Lajos; Yau, Tien Yin; Bashir, Sanum; Zidek, Vaclav; Landa, Vladimír; Geurts, Aron; Pravenec, Michal; Rülicke, Thomas; Bösze, Zsuzsanna; Izsvák, Zsuzsanna

    2014-04-01

    The laboratory rabbit (Oryctolagus cuniculus) is widely used as a model for a variety of inherited and acquired human diseases. In addition, the rabbit is the smallest livestock animal that is used to transgenically produce pharmaceutical proteins in its milk. Here we describe a protocol for high-efficiency germline transgenesis and sustained transgene expression in rabbits by using the Sleeping Beauty (SB) transposon system. The protocol is based on co-injection into the pronuclei of fertilized oocytes of synthetic mRNA encoding the SB100X hyperactive transposase together with plasmid DNA carrying a transgene construct flanked by binding sites for the transposase. The translation of the transposase mRNA is followed by enzyme-mediated excision of the transgene cassette from the plasmids and its permanent genomic insertion to produce stable transgenic animals. Generation of a germline-transgenic founder animal by using this protocol takes ∼2 months. Transposon-mediated transgenesis compares favorably in terms of both efficiency and reliable transgene expression with classic pronuclear microinjection, and it offers comparable efficacies (numbers of transgenic founders obtained per injected embryo) to lentiviral approaches, without limitations on vector design, issues of transgene silencing, and the toxicity and biosafety concerns of working with viral vectors.

  8. Germline transgenesis in rodents by pronuclear microinjection of Sleeping Beauty transposons.

    Science.gov (United States)

    Ivics, Zoltán; Mátés, Lajos; Yau, Tien Yin; Landa, Vladimír; Zidek, Vaclav; Bashir, Sanum; Hoffmann, Orsolya I; Hiripi, László; Garrels, Wiebke; Kues, Wilfried A; Bösze, Zsuzsanna; Geurts, Aron; Pravenec, Michal; Rülicke, Thomas; Izsvák, Zsuzsanna

    2014-04-01

    We describe a protocol for high-efficiency germline transgenesis and sustained transgene expression in two important biomedical models, the mouse and the rat, by using the Sleeping Beauty transposon system. The procedure is based on co-injection of synthetic mRNA encoding the SB100X hyperactive transposase, together with circular plasmid DNA carrying a transgene construct flanked by binding sites for the transposase, into the pronuclei of fertilized oocytes. Upon translation of the transposase mRNA, enzyme-mediated excision of the transgene cassettes from the injected plasmids followed by permanent genomic insertion produces stable transgenic animals. Generation of a germline-transgenic founder animal by using this protocol takes ∼3 months. Transposon-mediated transgenesis compares favorably in terms of both efficiency and reliable transgene expression with classic pronuclear microinjection, and it offers comparable efficacies to lentiviral approaches without limitations on vector design, issues of transgene silencing, and the toxicity and biosafety concerns of working with viral vectors.

  9. Directed altruistic living donation: what is wrong with the beauty contest?

    Science.gov (United States)

    Moorlock, Greg

    2015-11-01

    This paper explores the specific criticism of directed altruistic living organ donation that it creates a 'beauty contest' between potential recipients of organs. The notion of the beauty contest in transplantation was recently used by Neidich et al who stated that '[a]ltruism should be the guiding motivation for all donations, and when it [is], there is no place for a beauty contest'. I examine this beauty contest objection from two perspectives. First, I argue that, when considered against the behaviour of donors, this objection cannot be consistently raised without also objecting to other common aspects of organ donation. I then explore the beauty contest objection from the perspective of recipients, and argue that if the beauty contest is objectionable, it is because of a tension between recipient behaviour and the altruism that supposedly underpins the donation system. I conclude by briefly questioning the importance of this tension in light of the organ shortage. PMID:26126975

  10. Directed altruistic living donation: what is wrong with the beauty contest?

    Science.gov (United States)

    Moorlock, Greg

    2015-11-01

    This paper explores the specific criticism of directed altruistic living organ donation that it creates a 'beauty contest' between potential recipients of organs. The notion of the beauty contest in transplantation was recently used by Neidich et al who stated that '[a]ltruism should be the guiding motivation for all donations, and when it [is], there is no place for a beauty contest'. I examine this beauty contest objection from two perspectives. First, I argue that, when considered against the behaviour of donors, this objection cannot be consistently raised without also objecting to other common aspects of organ donation. I then explore the beauty contest objection from the perspective of recipients, and argue that if the beauty contest is objectionable, it is because of a tension between recipient behaviour and the altruism that supposedly underpins the donation system. I conclude by briefly questioning the importance of this tension in light of the organ shortage.

  11. What is beautiful is good because what is beautiful is desired: physical attractiveness stereotyping as projection of interpersonal goals.

    Science.gov (United States)

    Lemay, Edward P; Clark, Margaret S; Greenberg, Aaron

    2010-03-01

    The authors posit that the attribution of desirable interpersonal qualities to physically attractive targets is a projection of interpersonal goals; people desire to form and maintain close social bonds with attractive targets and then project these motivations onto those targets. Three studies support this model. Tendencies to see attractive novel targets depicted in photographs (Study 1), attractive romantic partners (Study 2), and attractive friends (Study 3) as especially interpersonally receptive and responsive were explained by perceivers' heightened desires to bond with attractive individuals. Additional findings regarding response latencies (Study 1) also supported this model. Many instances of the "beautiful is good" effect may not reflect stereotyping as it is typically construed. Rather, they may reflect projection of heightened desires to bond with beautiful people. PMID:20179314

  12. What is beautiful is good because what is beautiful is desired: physical attractiveness stereotyping as projection of interpersonal goals.

    Science.gov (United States)

    Lemay, Edward P; Clark, Margaret S; Greenberg, Aaron

    2010-03-01

    The authors posit that the attribution of desirable interpersonal qualities to physically attractive targets is a projection of interpersonal goals; people desire to form and maintain close social bonds with attractive targets and then project these motivations onto those targets. Three studies support this model. Tendencies to see attractive novel targets depicted in photographs (Study 1), attractive romantic partners (Study 2), and attractive friends (Study 3) as especially interpersonally receptive and responsive were explained by perceivers' heightened desires to bond with attractive individuals. Additional findings regarding response latencies (Study 1) also supported this model. Many instances of the "beautiful is good" effect may not reflect stereotyping as it is typically construed. Rather, they may reflect projection of heightened desires to bond with beautiful people.

  13. Dormitory of Physical and Engineering Sciences: Sleeping Beauties May Be Sleeping Innovations

    OpenAIRE

    van Raan, Anthony F. J.

    2015-01-01

    A 'Sleeping Beauty in Science' is a publication that goes unnoticed ('sleeps') for a long time and then, almost suddenly, attracts a lot of attention ('is awakened by a prince'). The aim of this paper is to present a general methodology to investigate (1) important properties of Sleeping Beauties such as the time-dependent distribution, author characteristics, journals and fields, and (2) the cognitive environment of Sleeping Beauties. We are particularly interested to find out to what extent...

  14. Socio-economic Conditions of Tribal Female Workers of the Beauty Parlors in Bangladesh

    OpenAIRE

    Nargis Akhter; Feroz Ahmed; Sohrab Hossain

    2011-01-01

    The study highlights the socio-economic conditions of tribal female workers of the beauty parlors in Bangladesh. The study consists of 240 sample tribal female workers of the different beauty parlors situated in six divisional towns of Bangladesh and judgment sampling technique was used to select this sample. The study reveals that tribal women working at beauty parlor draw competitively higher salary than other tribal people; they live at a comparatively healthy physical environment provided...

  15. Determination of toxic elements in beauty creams by X-ray spectrometric techniques (2001-2002)

    International Nuclear Information System (INIS)

    This paper is carried out to examine the contents of toxic heavy metals in various kinds of beauty creams by using Energy Dispersive X-ray Fluorescence Technique (EDXRF). By applying EDXRF system, it si found that most of the beauty creams contained titanium and zinc, and some of the beauty creams contained lead, bismuth, iron and mercury. Among the heavy toxic metals, mercury is the most harmful to human's health. (author)

  16. Shaping the female student : an analysis of Swedish beauty school recruitment texts

    OpenAIRE

    Bredlöv, Eleonor

    2016-01-01

    This study focuses on the recruitment of adults to the beauty industry in Sweden. It is concerned with a move in (beauty) education away from state and towards private provision in a wider context where education is becoming more heavily marketised. Drawing on a poststructural approach inspired by the work of Foucault and feminist theory, the shaping of student subjectivity in recruitment material for private beauty schools is analysed. A poststructural approach provides analytical tools that...

  17. Antecedents and consequences of creativity and beauty judgements in consumer products

    OpenAIRE

    Christensen, Bo T.; Kristensen, Tore; Reber, Rolf

    2009-01-01

    The literature in consumer psychology has tended to lack a clear separation between theoretical models of creativity and beauty evaluations of products. The present study examined whether creativity and beauty affected willingness to pay jointly or separately. In three experiments using paintings, wrist watches and designer lamps as stimuli, the present study shows how creativity and beauty both positively influence consumer willingness-to-pay for the product, but each expla...

  18. Measurement of beauty quark mass at HERA and impact on Higgs production in association with beauty quarks at LHC

    CERN Document Server

    Gizhko, Andrii; Foster, Brian

    2016-01-01

    Three different, but related topics are the subject of this thesis, performed in the contextof the ZEUS and CMS groups at DESY. The first measurement of the MS beauty-quarkmass mb (mb ) at an electron-proton collider is presented. The measurement is based ona QCD analysis of beauty production cross sections in deep inelastic (DIS) ep scatteringmeasured by ZEUS at HERA, together with inclusive DIS HERA data, using Next-toLeading-Order QCD predictions. The measured value of the running beauty-quark massin the MS scheme was found to bemb (mb ) = 4.07 ± 0.14 (fit)+0.01 (mod.)+0.05 (param.) +0.08 (theo.) GeV, which is in good−0.07−0.00−0.05agreement with the world average Particle Data Group value and previous measurementsat electron-positron colliders. It is also found to be consistent with the expected runningof mb (µ).A first measurement of the charm-quark mass mc (µ) running in the MS scheme ispresented. The measurement is based on a QCD analysis of the published H1 and ZEUScombination of charm cr...

  19. Evaluation of various anthropometric proportions in Indian beautiful faces: A photographic study

    Directory of Open Access Journals (Sweden)

    Saaransh Kalra

    2015-01-01

    Full Text Available Introduction: The subject of beauty has been the topic of much debate throughout history, and methods for the evaluation of beauty have been the focus of many research projects. The evaluation of beauty is influenced by factors which include various linear measurements, angles, ratios, and proportions. We evaluated several ratios in Indian Population after locating various landmarks on beautiful Indian faces. Aims and Objectives: The aim of the present study was to evaluate various facial proportions of Indian beauties using their frontal photographs in natural head position to establish anthropometric norms in beautiful Indian females. To evaluate whether these values satisfy golden and silver proportions. To compare these values with Caucasian anthropometric norms. Materials and Methods: Frontal photographs of 30 female celebrities were downloaded from the internet. Photographs of only those Indian beauties that have been declared winners of either national or international beauty contests by a designated panel of judges were included in this study. Hardcopy of these photographs was taken in 5 inch by 3.5 inch format, all the measurements done and ratios calculated. Results: Measurements were tabulated and values for various ratios were calculated to establish norms. Coefficient of variation was also evaluated. Conclusion: All the ratios were found to be consistent than others which made it possible to assess beauty objectively rather than arbitrarily. Most of the values did not match the golden and silver proportion. In comparison with Caucasian population, we found that there is significant difference in most of the values.

  20. The Khuner Haus by Adolf Loos - a critical study of beauty and desire

    DEFF Research Database (Denmark)

    Fisker, Anna Marie; Hvejsel, Marie Frier; Møller, Hans Ramsgaard

    Pondering about beauty’s relevance, meanings, and perhaps even the spell beauty can cast, we settle in comfortable chairs on the terrace of the Khuner Haus in the mountains close to Vienna. Heavy drifting clouds nearly touch the ground on the plateau around us this autumn afternoon. Our goal...... is to decipherer the architect Adolf Loos’ work, the Khuner Haus, and we put forth the question; do we in Loos’ architecture and thinking find a “Beauty in spite of Nature” as opposed to a “Beauty within Nature”? And if this is the dispute, how has the existence of beauty been challenged? The point of departure...